disease conditions nelson: Topics by WorldWideScience.org

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Nelson syndrome: definition and management.

Science.gov (United States)

Barber, T M; Adams, E; Wass, J A H

2014-01-01

Nelson syndrome is an important complication of treatment with total bilateral adrenalectomy (TBA) for patients with refractory Cushing's disease. Although early cases of Nelson syndrome often presented with the clinical features of large sellar masses, the modern face of Nelson syndrome has changed primarily due to earlier detection (with highly resolved magnetic resonance imaging (MRI) and sensitive ACTH assays) and greater awareness of the condition, resulting in reduced morbidity and mortality. Although lack of administration of neoadjuvant pituitary radiotherapy post-TBA surgery may predict future development of Nelson syndrome, other predictive factors remain controversial. Therefore, Nelson syndrome should be screened for closely and long-term in all patients with a history of Cushing's disease and TBA. The diagnosis of Nelson syndrome remains controversial, and the pathogenesis of this condition is incompletely understood. Current hypotheses include the "released negative feedback" mechansism (residual pituitary corticotropinoma cells are "released" from the negative feedback effects of cortisol following TBA), and the "aggressive corticotropinoma" mechanism (Nelson syndrome is most likely to develop in those patients with refractory treatments - including TBA - for an underlying aggressive corticotropinoma). Effective management of Nelson syndrome with pituitary surgery and radiotherapy is often a challenge. Other therapies (such as Gamma Knife surgery and temozolomide) play an important role and merit further research into their efficacy and placement in the management pathway of Nelson syndrome. © 2014 Elsevier B.V. All rights reserved.
Gamma knife radiosurgery for Cushing's disease and Nelson's syndrome.

Science.gov (United States)

Marek, Josef; Ježková, Jana; Hána, Václav; Kršek, Michal; Liščák, Roman; Vladyka, Vilibald; Pecen, Ladislav

2015-06-01

This paper presents our 18 years of experience in treating ACTH secreting adenomas (Cushing's disease and Nelson's syndrome) using the Leksell gamma knife (LGK) irradiation. Twenty-six patients with Cushing's disease were followed-up after LGK irradiation for 48-216 months (median 78 months). Seventeen patients had undergone previous surgery, in nine patients LGK irradiation was the primary therapy. Furthermore, 14 patients with Nelson's syndrome were followed-up for 30-204 months (median 144 months). LGK treatment resulted in hormonal normalization in 80.7 % of patients with Cushing's disease. Time to normalization was 6-54 months (median 30 months). The volume of the adenoma decreased in 92.3% (in 30.7% disappeared completely). There was no recurrence of the disease. In all 14 patients with Nelson's syndrome ACTH levels decreased (in two patients fully normalized) their ACTH levels. When checked up 5-10 years after irradiation regrowth of the adenoma was only detected in one patient (9.1%), in 27.3% adenoma volume remained unchanged, in 45.4% adenoma volume decreased and in 18.2% adenoma completely disappeared. Hypopituitarism did not develop in any patient where the critical dose to the pituitary and distal infundibulum was respected. LGK radiation represents an effective and well-tolerated option for the treatment of patients with Cushing's disease after unsuccessful surgery and may be valuable even as a primary treatment in patients who are not suitable for, or refuse, surgery. In the case of Nelson's syndrome it is possible to impede tumorous growth and control the size of the adenoma in almost all patients.
Gamma Knife Radiosurgery for Cushing's Disease and Nelson's Syndrome

Czech Academy of Sciences Publication Activity Database

Marek, J.; Ježková, J.; Hána, V.; Kršek, M.; Liščák, R.; Vladyka, V.; Pecen, Ladislav

2015-01-01

Roč. 18, č. 3 (2015), s. 376-384 ISSN 1386-341X Institutional support: RVO:67985807 Keywords : Cushing's disease * Nelson's syndrome * Gamma knife surgery * Pituitary adenoma Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 3.407, year: 2015
Nelson syndrome: historical perspectives and current concepts.

Science.gov (United States)

Hornyak, Mark; Weiss, Martin H; Nelson, Don H; Couldwell, William T

2007-01-01

The appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment of Cushing disease has changed drastically since the 1950s, when the choice was adrenalectomy. Thus, the occurrence, diagnosis, and treatment of Nelson syndrome have changed as well. In the modern era of high-resolution neuroimaging, transsphenoidal microneurosurgery, and stereotactic radiosurgery, Nelson syndrome has become a rare entity. The authors describe the history of the diagnosis and treatment of Nelson syndrome. In light of the changes described, the authors believe this disease must be reevaluated in the contemporary era and a modern paradigm adopted.
Nelson`s syndrome associated with a somatic frame shift mutation in the glucocorticoid recepter gene

Energy Technology Data Exchange (ETDEWEB)

Karl, M.; Stratakis, C.A.; Chrousos, G.P.; Katz, D.A.; Ali, I.U.; Oldfield, E.H. [National Inst. of Neurological Disorders and Stroke, Bethesda, MD (United States)] [and others

1996-01-01

Nelson`s syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing`s disease. Extremely high plasma ACTH levels and aggressive neoplastic growth might be explained by the lack of appropriate glucocorticoid negative feedback due to defective glucocorticoid signal transduction. To study the glucocorticoid receptor (GR) gene in Nelson`s syndrome, DNA was extracted from pituitary adenomas and leukocytes of four patients with this condition and amplified by PCR for direct sequence analysis. In one of the tumors, a heterozygous mutation, consisting of an insertion of a thymine between complementary DNA nucleotides 1188 and 1189, was found in exon 2. This frame-shift mutation led to premature termination at amino acid residue 366 of the world-type coding sequence, excluding the expression of a functioning receptor protein from the defective allele. The mutation was not detected in the sequence of the GR gene in the patient`s leukocyte DNA, indicating a somatic origin. By lowering the receptor number in tumorous cells, this defect might have caused local resistance to negative glucocorticoid feedback similar to that caused by the presence of a null allele in a kindred with the generalized glucocorticoid resistance syndrome. P53 protein accumulation, previously reported in 60% of corticotropinomas, could not be detected in any of the four pituitary tumors examined by immunohistochemistry. We suggest that a somatic GR defect might have played a pathophysiological role in the tumorigenesis of the corticotropinoma bearing this mutation. 35 refs., 3 figs., 1 tab.
MRI versus CT in the diagnosis of Nelson's syndrome

International Nuclear Information System (INIS)

Kasperlik-Zaluska, A.; Walecki, J.; Brzezinski, J.; Jeske, W.; Migdalska, B.; Bonicki, W.; Brzezinska, A.; Makowska, A.

1997-01-01

The purpose of the study was to evaluate the utility of MRI and CT in the diagnosis of Nelson's syndrome, i. e. pituitary tumours in patients bilaterally adrenalectomized for Cushing's disease. Thirteen patients, followed up for 5-29 years after adrenalectomy, were studied. In 6 of them CT and MRI revealed no changes in the pituitary gland. In the remaining 7 patients only three CT scans were suggestive of a pituitary adenoma. MRI studies with administration of gadodiamide confirmed the CT diagnosis of Nelson's tumour in 3 patients and disclosed microadenomas in a further 4 patients. Neurosurgical treatment in 4 patients confirmed the MRI findings. Additionally CT and MRI examinations were performed in 5 patients suspected of a recurrent Nelson's tumour 3-11 years after neurosurgery. MRI visualized recurrent adenomas in 3 patients that were not well seen by CT scans. In our experience MRI was more effective than CT in the diagnosis of Nelson's syndrome. (orig.). With 3 figs., 1 tab
A new look at Bell's inequalities and Nelson's theorem

International Nuclear Information System (INIS)

Schulz, B.

2009-01-01

In 1985, Edward Nelson, who formulated the theory of stochastic mechanics, made an interesting remark about Bell's theorem. Nelson analysed the latter in the light of classical fields that behave randomly. He found that if a stochastic hidden variable theory fulfils certain conditions, the inequality of Bell can be violated. Moreover, Nelson was able to prove that this may happen without any instantaneous communication between the two spatially separated measurement stations. Since Nelson's article got almost overlooked by physicists, we try to review his comments on the theorem. We argue that a modification of stochastic mechanics published recently by Fritsche and Haugk can be extended to a theory which fulfils the requirements of Nelson's analysis. The article proceeds to derive the quantum mechanical formalism of spinning particles and the Pauli equation from this version of stochastic mechanics. Then, we investigate Bohm's version of the EPR experiment. Additionally, other setups, like entanglement swapping or time and position correlations, are shortly explained from the viewpoint of our local hidden-variable model. Finally, we mention that this theory could perhaps be relativistically extended and useful for the formulation of quantum mechanics in curved space-times. (Abstract Copyright [2009], Wiley Periodicals, Inc.)
Nelson Syndrome: Update on Therapeutic Approaches.

Science.gov (United States)

Azad, Tej D; Veeravagu, Anand; Kumar, Sunny; Katznelson, Laurence

2015-06-01

To review the pathophysiology and therapeutic modalities availble for Nelson syndrome. We reviewed the current literature including managment for Nelson syndrome. For patients with NS, surgical intervention is often the first-line therapy. With refractory NS or tumors with extrasellar involvement, radiosurgery offers an important alternative or adjuvant option. Pharmacologic interventions have demonstrated limited usefulness, although recent evidence supports the feasibility of a novel somatostatin analog for patients with NS. Modern neuroimaging, improved surgical techniques, and the advent of stereotactic radiotherapy have transformed the management of NS. An up-to-date understanding of the pathophysiology underlying Nelson Syndrome and evidence-based management is imperative. Early detection may allow for more successful therapy in patients with Nelson Syndrome. Improved radiotherapeutic interventions and rapidly evolving pharmacologic therapies offer an opportunity to create targeted, multifocal treatment regiments for patients with Nelson Syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.
Megavoltage pituitary irradiation in the management of Cushing's disease and Nelson's syndrome: long-term follow-up

International Nuclear Information System (INIS)

Howlett, T.A.; Plowman, P.N.; Wass, J.A.H.; Rees, L.H.; Jones, A.E.; Besser, G.M.

1989-01-01

The authors report the long-term follow-up (up to 17.3 years) of the clinical and biochemical effects of megavoltage pituitary irradiation (radiotherapy;RT), administered as primary or secondary therapy, for pituitary Cushing's disease and Nelson's syndrome in 52 patients. Irradiation was administered, from a 4-15 MeV linear accelerator, via a three-field technique, to a total dose of 4500 cGy (rad) in 25 fractions over 35 days. (author)
Product spaces and Nelson's inequality

International Nuclear Information System (INIS)

Faris, W.G.

1976-01-01

Certain inequalities for unbounded linear operators in L 2 extend to product spaces. This product space property is used to give a new proof that Gross's inequality for matrices implies Nelson's inequality for ordinary differential operators, and that this in turn implies Nelson's inequality for partial differential operators in infinitely many dimensions. A new proof of Gross's inequality is given. There is also a discussion of the physical meaning of Nelson's inequality in quantum field theory. The article may serve as an introduction for non-specialists to some of the recent mathematical work in this subject. (Auth.)
78 FR 75205 - Death of Nelson Mandela

Science.gov (United States)

2013-12-10

... of Nelson Mandela By the President of the United States of America Proclamation Today, the United... an inspiration for freedom, justice, and human dignity--Nelson Mandela is no longer with us, he belongs to the ages. Nelson Mandela achieved more than could be expected of any man. His own struggle...
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease

NARCIS (Netherlands)

van Aken, Maarten O.; Pereira, Alberto M.; van den Berg, Gerrit; Romijn, Johannes A.; Veldhuis, Johannes D.; Roelfsema, Ferdinand

2004-01-01

As described originally, Nelson's syndrome is characterized by grossly elevated ACTH concentrations, a sellar mass and skin hyperpigmentation emerging in the course of Cushing's disease after bilateral adrenalectomy. No detailed studies have defined whether the mechanisms directing ACTH secretion
accuracy of nelson and best guess formulae in estimation of weights

African Journals Online (AJOL)

treatment decisions including nutritional status assessment, drug ... weight estimations in infants and children aged 6-11 years. ... include: the Nelson formulae,7,8 Advanced Paediatric ... measured according to the Center for Disease Control.
Nelson-Farrar cost indexes

International Nuclear Information System (INIS)

Anon.

1992-01-01

This paper discusses the Nelson-Farrar Cost Indexs. Topics covered include: economic analysis, petroleum refineries, petroleum industry, pumps, compressors, beat exchangers, cost estimation, productivity and wages
The search for a more human face for Nelson Mandela: An urgent task

OpenAIRE

Tinyiko Maluleke

2015-01-01

For many reasons, reflecting on the life of Nelson Mandela is a precarious exercise. If Mandela is a symbol of the resilience of the human spirit under trying conditions, he is also a symbol that is appropriated in various ways – helpful and unhelpful – by various people. This article explores some of the unhelpful ways in which the name and person of Nelson Mandela is invoked. In particular, the article looks at the hagiographical orientation of several reflections on Mandela, cautioning ...
Debating the Social Thinking of Carlos Nelson Coutinho

Directory of Open Access Journals (Sweden)

Bruno Bruziguessi

2017-10-01

Full Text Available BRAZ, Marcelo; RODRIGUES, Mavi (Org.. Cultura, democracia e socialismo: as idéias de Carlos Nelson Coutinho em debate. [Culture, democracy and socialism: The ideas of Carlos Nelson Coutinho in debate]. Rio de Janeiro: Mórula, 2016. 248 p.
Meet EPA's Dan Nelson

Science.gov (United States)

EPA’s Dan Nelson is the Director of the Human Research Protocol Office at the National Health and Environmental Effect Research Laboratory, Dan works to protect the rights and welfare of EPA’s research participants.
Nelson-Farrar quarterly costimating

International Nuclear Information System (INIS)

Farrar, G.

1993-01-01

This paper reports that continuing a trend starting in 1983, the Nelson-Farrar refinery construction index rose slowly from 1211.6 in January 1990, to 1265.8 in December 1991. The labor component of the index rose at a more rapid rate than did the material component. The labor index rose from 1469.5 to 1558.1 over the 2-year period, while the material index rose only 2.3 points, from 824.9 to 827.2. The miscellaneous equipment index rose 52.1 points in the 2-year comparison. The category includes pumps and compressors, electrical equipment, heat exchangers, instruments, and engines. They are thus manufactured items, and their costs are a measure of manufacturing efficiency. The Nelson-Farrar refinery operations index dropped 5.4 points, from 395.1 to 389.7 in the 1990-1991 period. The process unit index also showed a decrease over this period, dropping from 469.3 to 405.2
Challenges for the Nelson-Barr mechanism

International Nuclear Information System (INIS)

Dine, Michael; Draper, Patrick

2015-01-01

The axion and m u =0 solutions to the strong CP problem have been subject to the most careful scrutiny and critique. Basic theoretical issues include hierarchy and fine-tuning problems, quality and genericity of symmetries, and compatibility with solutions to the electroweak hierarchy problem. We study the similar set of challenges for solutions to strong CP based on spontaneous CP violation and the Nelson-Barr mechanism. Some of our observations have appeared in the literature previously, and others are new; our purpose is to collect and analyze the issues as a whole and provide an assessment of the most plausible settings for the Nelson-Barr solution.
On the domain of the Nelson Hamiltonian

Science.gov (United States)

Griesemer, M.; Wünsch, A.

2018-04-01

The Nelson Hamiltonian is unitarily equivalent to a Hamiltonian defined through a closed, semibounded quadratic form, the unitary transformation being explicitly known and due to Gross. In this paper, we study the mapping properties of the Gross-transform in order to characterize the regularity properties of vectors in the form domain of the Nelson Hamiltonian. Since the operator domain is a subset of the form domain, our results apply to vectors in the domain of the Hamiltonian as well. This work is a continuation of our previous work on the Fröhlich Hamiltonian.

Marilyn Nelson: Poetic Justice

Science.gov (United States)

Pierpont, Katherine

2006-01-01

This article features some of the books written by Marilyn Nelson. Here, the author discusses how she has written a children's book of poetry about lynching, entitled "A Wreath for Emmitt Till." The author discusses how her books for children honor and memorialize history-changing African Americans. Among other things, the author discusses some of…
Davidson's generalization of the Fenyes-Nelson stochastic model of quantum mechanics

International Nuclear Information System (INIS)

Shucker, D.S.

1980-01-01

Davidson's generalization of the Fenyes-Nelson stochastic model of quantum mechanics is discussed. It is shown that this author's previous results concerning the Fenyes-Nelson process extend to the more general theory of Davidson. (orig.)
Analyzing Oil Futures with a Dynamic Nelson-Siegel Model

DEFF Research Database (Denmark)

Hansen, Niels Strange; Lunde, Asger

In this paper we are interested in the term structure of futures contracts on oil. The objective is to specify a relatively parsimonious model which explains data well and performs well in a real time out of sample forecasting. The dynamic Nelson-Siegel model is normally used to analyze and forec......In this paper we are interested in the term structure of futures contracts on oil. The objective is to specify a relatively parsimonious model which explains data well and performs well in a real time out of sample forecasting. The dynamic Nelson-Siegel model is normally used to analyze...... and forecast interest rates of different maturities. The structure of oil futures resembles the structure of interest rates and this motivates the use of this model for our purposes. The data set is vast and the dynamic Nelson-Siegel model allows for a significant dimension reduction by introducing three...
Nodule management protocol of the NELSON randomised lung cancer screening trial

NARCIS (Netherlands)

Xu, Dong Ming; Gietema, Hester; de Koning, Harry; Vernhout, Rene; Nackaerts, Kristiaan; Prokop, Mathias; Weenink, Carla; Lammers, Jan-Willem; Groen, Harry; Oudkerk, Matthijs; van Klaveren, Rob

In December 2003, the Dutch-Belgian NELSON trial, a Dutch acronym for "Nederlands-Leuvens Longkanker Screenings ONderzoek", has been launched. Primary objective of the NELSON trial is to investigate whether screening for lung cancer by 16-detector multi-slice CT with 16 mm x 0.75 mm collimation and
Premium Pricing In Health Insurance By Nelson- Aalen Estimator

OpenAIRE

Istikaanah, Najmah

2011-01-01

In this paper the using of Nelson Aalen estimators are presented to estimate transition probabilities of multistate model. Based on discrete time Markov, we will get transition matrices?é?á which the elements are transition probabilities from Nelson Aalen estimator. Because of the data that used in the construction of transition matrices are person?óÔé¼Ôäós health histories, then it can be seen as a morbidity value, which can be used to premium pricing.?é?á
Asymptotic Completeness for a Renormalized Nonrelativistic Hamiltonian in Quantum Field Theory: The Nelson Model

International Nuclear Information System (INIS)

Ammari, Zied

2000-01-01

Scattering theory for the Nelson model is studied. We show Rosen estimates and we prove the existence of a ground state for the Nelson Hamiltonian. Also we prove that it has a locally finite pure point spectrum outside its thresholds. We study the asymptotic fields and the existence of the wave operators. Finally we show asymptotic completeness for the Nelson Hamiltonian
Political apathy amongst students: A case study of Nelson Mandela Metropolitan University

Directory of Open Access Journals (Sweden)

Ntsikelelo B. Breakfast

2017-09-01

Full Text Available The primary motivation for this research, in which a qualitative method was employed, was to examine political apathy amongst students at Nelson Mandela Metropolitan University. The secondary motivation was to question whether youth political apathy threatens the consolidation of democracy. The researchers arranged four focus groups at Nelson Mandela Metropolitan University. A purposive sampling technique was utilised. All 50 participants in the study were Nelson Mandela Metropolitan University undergraduate and postgraduate black students, with ages ranging from 21 to 35 years. The researchers encouraged participants to have maximum participation in the focus group deliberations. The researchers also made use of elite interviews in the study. The findings of this study suggest that political apathy does exist amongst students at Nelson Mandela Metropolitan University. Most of the participants in the focus groups indicated that young people in post-apartheid South Africa have no interest in politics.
STS-26 MS Nelson on fixed based (FB) shuttle mission simulator (SMS) middeck

Science.gov (United States)

1988-01-01

STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson trains on the middeck of the fixed based (FB) shuttle mission simulator (SMS). Nelson, wearing communications assembly headset, adjusts camera mounting bracket.
Nelson's syndrome in pregnancy

International Nuclear Information System (INIS)

Surrey, E.S.; Chang, R.J.

1985-01-01

The therapeutic considerations in the management of Nelson's syndrome in a 29 year old primigravida are described. CT scans revealed a 2-cm solid pituitary lesion with suprasellar extension and chiasmatic encroachment. A transsphenoidal hypophysectomy was performed to remove a eosinophilic pituitary adenoma. The patient's symptoms improved following surgery. Fetal growth was followed by ultrasound and a female infant was delivered by cesarean section. Follow-up CT scan 2 weeks after delivery revealed no evidence of tumor recurrence
The pure phases, the irreducible quantum fields, and dynamical symmetry breaking in Symanzik--Nelson positive quantum field theories

International Nuclear Information System (INIS)

Frohlich, J.

1976-01-01

We prove that a Symanzik--Nelson positive quantum field theory, i.e., a quantum field theory derived from a Euclidean field theory, has a unique decomposition into pure phases which preserves Symanzik--Nelson positivity and Poincare covariance. We derive useful sufficient conditions for the breakdown of an internal symmetry of such a theory in its pure phases, for the self-adjointness and nontrivially (in the sense of Borchers classes) of its quantum fields, and the existence of time-ordered and retarded products. All these general results are then applied to the P (phi) 2 and the phi 3 4 quantum field models
The search for a more human face for Nelson Mandela: An urgent task

Directory of Open Access Journals (Sweden)

Tinyiko Maluleke

2015-08-01

Full Text Available For many reasons, reflecting on the life of Nelson Mandela is a precarious exercise. If Mandela is a symbol of the resilience of the human spirit under trying conditions, he is also a symbol that is appropriated in various ways – helpful and unhelpful – by various people. This article explores some of the unhelpful ways in which the name and person of Nelson Mandela is invoked. In particular, the article looks at the hagiographical orientation of several reflections on Mandela, cautioning how some of these may have an effect less noble than originally intended. Accordingly, the article asks: How much can the symbol of Mandela bear? How much more can Mandela give? The logic and rationale of Mandela hagiography is explored. Following his death, there has been an explosion of interest in the life and symbol that is Nelson Mandela. Mandela literature, including multi-media, is on the rise. If the symbol of Mandela is in danger of being ‘cannibalised’, there is also a danger of relegating Mandela to an ahistorical mythical figure. The solution lies in at least two area, namely, the increment of alternative Mandela narratives and the introduction of more critical Mandela narratives. In this regard, Mandela’s own self-understanding as captured in his reflections about his life offer several clues which are explored in this article.
Observations of emperor geese feeding at Nelson Lagoon, Alaska

Science.gov (United States)

Petersen, Margaret R.

1983-01-01

Estuaries along the north side of the Alaska Peninsula provide essential habitat for most of the American population of Emperor Goose (Chen canagica) during migration (Petersen and Gill 1982). Most of the population passes through Nelson Lagoon in spring and fall, with over 40,000 birds recorded there (Gill et al 1981). Little is known about the feeding activity of Emperor Geese while they are in estuaries, and the importance of estuaries as staging areas during spring and fall migration is poorly understood. Here I report observations on the feeding activity of emperor Geese at one estuary (Nelson Lagoon).
Mercury in Nelson's Sparrow subspecies at breeding sites.

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Virginia L Winder

Full Text Available BACKGROUND: Mercury is a persistent, biomagnifying contaminant that can cause negative effects on ecosystems. Marshes are often areas of relatively high mercury methylation and bioaccumulation. Nelson's Sparrows (Ammodramus nelsoni use marsh habitats year-round and have been documented to exhibit tissue mercury concentrations that exceed negative effects thresholds. We sought to further characterize the potential risk of Nelson's Sparrows to mercury exposure by sampling individuals from sites within the range of each of its subspecies. METHODOLOGY/PRINCIPAL FINDINGS: From 2009 to 2011, we captured adult Nelson's Sparrows at sites within the breeding range of each subspecies (A. n. nelsoni: Grand Forks and Upham, North Dakota; A. n. alterus: Moosonee, Ontario; and A. n. subvirgatus: Grand Manan Island, New Brunswick and sampled breast feathers, the first primary feather (P1, and blood for total mercury analysis. Mean blood mercury in nelsoni individuals captured near Grand Forks ranged from 0.84 ± 0.37 to 1.65 ± 1.02 SD ppm among years, between 2.0 and 4.9 times as high as concentrations at the other sites (P<0.01. Breast feather mercury did not vary among sites within a given sampling year (site means ranged from 0.98 ± 0.69 to 2.71 ± 2.93 ppm. Mean P1 mercury in alterus (2.96 ± 1.84 ppm fw was significantly lower than in any other sampled population (5.25 ± 2.24-6.77 ± 3.51 ppm; P ≤ 0.03. CONCLUSIONS/SIGNIFICANCE: Our study further characterized mercury in Nelson's Sparrows near Grand Forks; we documented localized and potentially harmful mercury concentrations, indicating that this area may represent a biological mercury hotspot. This finding warrants further research to determine if wildlife populations of conservation or recreational interest in this area may be experiencing negative effects due to mercury exposure. We present preliminary conclusions about the risk of each sampled population to mercury exposure.
Mercury in Nelson's Sparrow Subspecies at Breeding Sites

Science.gov (United States)

Winder, Virginia L.; Emslie, Steven D.

2012-01-01

Background Mercury is a persistent, biomagnifying contaminant that can cause negative effects on ecosystems. Marshes are often areas of relatively high mercury methylation and bioaccumulation. Nelson's Sparrows (Ammodramus nelsoni) use marsh habitats year-round and have been documented to exhibit tissue mercury concentrations that exceed negative effects thresholds. We sought to further characterize the potential risk of Nelson's Sparrows to mercury exposure by sampling individuals from sites within the range of each of its subspecies. Methodology/Principal Findings From 2009 to 2011, we captured adult Nelson's Sparrows at sites within the breeding range of each subspecies (A. n. nelsoni: Grand Forks and Upham, North Dakota; A. n. alterus: Moosonee, Ontario; and A. n. subvirgatus: Grand Manan Island, New Brunswick) and sampled breast feathers, the first primary feather (P1), and blood for total mercury analysis. Mean blood mercury in nelsoni individuals captured near Grand Forks ranged from 0.84±0.37 to 1.65±1.02 SD ppm among years, between 2.0 and 4.9 times as high as concentrations at the other sites (Pmercury did not vary among sites within a given sampling year (site means ranged from 0.98±0.69 to 2.71±2.93 ppm). Mean P1 mercury in alterus (2.96±1.84 ppm fw) was significantly lower than in any other sampled population (5.25±2.24–6.77±3.51 ppm; P≤0.03). Conclusions/Significance Our study further characterized mercury in Nelson's Sparrows near Grand Forks; we documented localized and potentially harmful mercury concentrations, indicating that this area may represent a biological mercury hotspot. This finding warrants further research to determine if wildlife populations of conservation or recreational interest in this area may be experiencing negative effects due to mercury exposure. We present preliminary conclusions about the risk of each sampled population to mercury exposure. PMID:22384194
Grantee Spotlight: Bill Nelson, M.D., Ph.D.

Science.gov (United States)

Dr. William (Bill) Nelson is playing an integral role in advancing our understanding of cancer health disparities and helping to foster the interests of young students from underrepresented backgrounds in cancer/cancer health disparities research.
Report on the workshop examining the potential effects of hydroelectric development on Beluga of the Nelson River Estuary, Winnipeg, Manitoba, November 6 and 7, 1990

International Nuclear Information System (INIS)

Lawrence, M.J.; Paterson, M.; Baker, R.F.; Schmidt, R.

1992-01-01

A summary is presented of discussions and conclusions at a workshop held to examine the potential effects of hydroelectric development on beluga whales of the Nelson River estuary in Manitoba. Background information is provided on the estuary, beluga whales and their use of arctic and subarctic estuaries, and hydroelectric development on the Nelson River. Potential impacts of such development on the whales are reviewed in the categories of direct effects of changes in physical-chemical conditions (temperature and discharge), indirect effects of disturbances mediated through the food chain, and effects on socioeconomic conditions that may affect beluga whales. Since the biology of beluga whales and other phenomena of interest in this study are poorly known, recommendations are made for research and monitoring activities in the Nelson River estuary. In general, the workshop participants felt that changes in the estuary due to hydroelectric development would not be large enough to affect beluga whales strongly. 34 refs., 1 fig
Nelson Werneck Sodré e o "marxismo ocidental"

Directory of Open Access Journals (Sweden)

Wilson do Nascimento Barbosa

1999-12-01

Full Text Available This articles discusses Nelson Pereira dos Santos' movie Arid lifes, made after homonym Graciliano Ramos' book. Werneck Sodré's methological questions are evoked from book and movie subjects as rural poverty and dayly violence.
Philosophical Remarks on Nelson Mandela's Education Legacy

Science.gov (United States)

Waghid, Yusef

2014-01-01

In this article, I reflect on Nelson Mandela's (Madiba, the clan name of Mandela) education legacy. I argue that Madiba's education legacy is constituted by three interrelated aspects: firstly, an education for non-violence guided by deliberation, compassion and reconciliation; secondly, education as responsibility towards the Other; and thirdly,…
78 FR 56224 - Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption

Science.gov (United States)

2013-09-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 3401-049] Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption 1. By documentation filed July 8, 2013 and supplemented... Hydro-WM, LLC. The project is located on the Rockfish River in Nelson County, Virginia. The transfer of...
Nelson Maculan Filho: cientista e educador

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Ribeiro Celso Carneiro

2003-01-01

Full Text Available Este texto é um pequeno e merecido tributo ao Professor Nelson Maculan Filho por ocasião do seu 60masculine aniversário, em reconhecimento às suas grandes contribuições à Universidade brasileira. Como amigos, colaboradores e ex-alunos, ficamos sensibilizados e honrados com o convite feito pelo Professor Jayme Luiz Szwarcfiter para escrever este artigo. Carpe diem, querido amigo Maculan!

Nelson ja Rodney - inglaste erandlikud lahingulaevad / Sander Kingsepp

Index Scriptorium Estoniae

Kingsepp, Sander

2006-01-01

1922. aastal Washingtonis alla kirjutatud mereväerelvastuse lepe läks ajalukku äpardunud katsena võidurelvastamisele piir panna. Leppega ühinenud riigid hakkasid ilmutama veidra välimusega sõjalaevu, mille seas olid aukohal Briti alused "Nelson" ja "Rodney"
Score-Driven Nelson Siegel: Hedging Long-Term Liabilities

NARCIS (Netherlands)

R. Quaedvlieg (Rogier); P.C. Schotman (Peter)

2016-01-01

textabstractDue to its affine structure the Nelson-Siegel model for yield curves can be transformed to a factor model for excess bond returns. Hedging interest rate risk in this framework amounts to eliminating the factor exposure and minimizing the residual risk. Fitting the model directly on
Nelson's syndrome: single centre experience using the linear accelerator (LINAC) for stereotactic radiosurgery and fractionated stereotactic radiotherapy.

Science.gov (United States)

Wilson, Peter J; Williams, Janet R; Smee, Robert I

2014-09-01

Nelson's syndrome is a unique clinical phenomenon of growth of a pituitary adenoma following bilateral adrenalectomies for the control of Cushing's disease. Primary management is surgical, with limited effective medical therapies available. We report our own institution's series of this pathology managed with radiation: prior to 1990, 12 patients were managed with conventional radiotherapy, and between 1990 and 2007, five patients underwent stereotactic radiosurgery (SRS) and two patients fractionated stereotactic radiotherapy (FSRT), both using the linear accelerator (LINAC). Tumour control was equivocal, with two of the five SRS patients having a reduction in tumour volume, one patient remaining unchanged, and two patients having an increase in volume. In the FSRT group, one patient had a decrease in tumour volume whilst the other had an increase in volume. Treatment related morbidity was low. Nelson's syndrome is a challenging clinical scenario, with a highly variable response to radiation in our series. Copyright © 2014 Elsevier Ltd. All rights reserved.
‘Magic Negro’, Saint or Comrade: Representations of Nelson Mandela in Film

OpenAIRE

Roger Bromley

2014-01-01

“In the late 1980s, Nelson Mandela stood alone against the apartheid state.” This comment taken from the DVD Box set cover of Nelson Mandela: From Freedom to History summarises the approach taken by many of the cinematic and televisual representations of Mandela. Linked with this is a statement by the CEO of Marriott which speaks of Mandela as “an individual who changed the arc of history through his or her singular contribution, not as a function of the era or the movement but because of wha...
Book Review: Nelson Mandela: A Jacana Pocket Biography ...

African Journals Online (AJOL)

Book Title: Nelson Mandela: A Jacana Pocket Biography. Author: Colin Bundy. Jacana: Auckland Park, 2015. 159 pp. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...
Modeling of Chromium (III) Removal from Heavy Metals Mixture Solutions in Continuous Flow Systems: A Comparative Study between BDST and Yoon -Nelson Models

International Nuclear Information System (INIS)

Ahmed, A.Z.

2011-01-01

The aim of this work is to study modeling of chromium (III) removal from aqueous solution using activated carbon as adsorbent. Studies have been conducted in a continuous fixed bed packed column under different operating conditions such as bed height, flow rate, fluid velocity and fixed adsorbent particle size. The Yoon Nelson model was applied to experimental data to predict the breakthrough curves by calculating the rate constant k and 50 % breakthrough time, θ. The Bed Depth Service Time (BDST) was applied to determine BDST constant K and the capacity of adsorbent, No. Results obtained from both models are compared with the experimental breakthrough curves and a satisfactory agreement was noticed. Therefore, the Yoon - Nelson and BDST models were found suitable for determining the parameters of the column design. The Y 000 - Nelson model was found more accurate in representing the system in comparison with the BDST model although it is less complicated than other models
78 FR 66353 - EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2349-000] EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of EAM Nelson...
Nelson's syndrome in pregnancy

Energy Technology Data Exchange (ETDEWEB)

Surrey, E.S.; Chang, R.J.

1985-10-01

The therapeutic considerations in the management of Nelson's syndrome in a 29 year old primigravida are described. CT scans revealed a 2-cm solid pituitary lesion with suprasellar extension and chiasmatic encroachment. A transsphenoidal hypophysectomy was performed to remove a eosinophilic pituitary adenoma. The patient's symptoms improved following surgery. Fetal growth was followed by ultrasound and a female infant was delivered by cesarean section. Follow-up CT scan 2 weeks after delivery revealed no evidence of tumor recurrence.
Convergence of Nelson diffusions

International Nuclear Information System (INIS)

Dell'Antonio, G.; Posilicano, A.

1991-01-01

Let ψ t , ψ t n , n≥1, be solutions of Schroedinger equations with potentials form-bounded by -1/2 Δ and initial data in H 1 (R d ). Let P, P n , n≥1, be the probability measures on the path space Ω=C(R + , R d ) given by the corresponding Nelson diffusions. We show that if {ψ t n } n≥1 converges to ψ t in H 2 (R d ), uniformly in t over compact intervals, then {P n } n≥1 converges to P in total variation. Moreover, if the potentials are in the Kato class K d , we show that the above result follows from H 1 -convergence of initial data, and K d -convergence of potentials. (orig.)
PREDIKSI PUNCAK KEMATANGAN BUAH NAGA MELALUI PENGUKURAN GULA REDUKSI DENGAN METODE NELSON-SOMOGYI

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Alimuddin -

2016-01-01

Full Text Available Prediction of dragon fruit maturation peak by measuring reductor sugar with nelson-somogyi method have been done. Prediction was done by using three modes which are experimental result, regression model and first derivation. Age of the fruit which used in this research were 1, 3, 5 and 7 weeks old. Based on the result of this research can be concluded that maturation peak of dragon fruit happens at between 5 until 6 weeks old. Keywords: Dragon Fruit, Reductor Sugar and Nelson-Somogyi Method.
Corner Office Interview: SirsiDynix's Rautenstrauch and Nelson

Science.gov (United States)

Rapp, David; Fialkoff, Francine

2010-01-01

This article presents an interview with SirsiDynix CEO Gary M. Rautenstrauch and newly appointed VP of library relations Berit Nelson about some of the issues that have been roiling the ILS world and the company itself, among them the recent consolidation of SirsiDynix's offices, customer service, the state of library budgets, the rise of ebooks…
Kunda "liumägi" / Ago Kastemäe, Huviklubi Nelson

Index Scriptorium Estoniae

Kastemäe, Ago

2014-01-01

Millistel tingimustel on võimalik Kunda jõel paiknevast hüdroelektrijaama tammist süsta või raftiga alla sõita. Huviklubi Nelson pakub koostöös Lontova Seikluspargiga Kunda jõel juhendajatega raftimatku
Analyzing the term structure of interest rates using the dynamic Nelson-Siegel model with time-varying parameters

NARCIS (Netherlands)

Koopman, S.J.; Mallee, M.I.P.; van der Wel, M.

2010-01-01

In this article we introduce time-varying parameters in the dynamic Nelson-Siegel yield curve model for the simultaneous analysis and forecasting of interest rates of different maturities. The Nelson-Siegel model has been recently reformulated as a dynamic factor model with vector autoregressive
Nelson Mandela and the Power of Ubuntu

Directory of Open Access Journals (Sweden)

Claire E. Oppenheim

2012-04-01

Full Text Available Nelson Mandela dedicated his life to fighting for the freedom of his South African kin of all colors against the institution of apartheid. He spent twenty-seven years fighting from within prison, only gaining his freedom when his fellow South Africans could claim it as well. This article demonstrates how his faith, his spiritual development and his noble purpose can be conceptualized through the lens of Ubuntu: the African ethic of community, unity, humanity and harmony.
Rebuttal to Nelson et al. 'Response to Bodin and Grote regarding postdoctoral recruitment in clinical neuropsychology'.

Science.gov (United States)

Bodin, Doug; Grote, Christopher L

2016-07-01

Nelson et al. provided a response to our commentary on the postdoctoral match in clinical neuropsychology. In this brief rebuttal, we will focus on statements from Nelson et al. that we believe are factual inaccuracies or misunderstandings of some of the points we made in our commentary. In addition, we will comment briefly on the proposed guidelines offered in their response.
A Good Time: A Conversation with C. Michael Nelson

Science.gov (United States)

Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

2015-01-01

C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…
A Message from Nelson Mandela to the Youth of America.

Science.gov (United States)

Mandela, Nelson

1995-01-01

Presents a message to young people from Nelson Mandela, president of South Africa. Calls for a bridge between the youth of Africa and the United States. Asserts that racial divisions in the United States are major social issues that must be solved. (CFR)
Romance and Freedom: Nelson and Winnie Mandela’s Politics of Gender in Three Post-Apartheid Novels

Directory of Open Access Journals (Sweden)

Lorenzo Mari

2014-11-01

Full Text Available This paper aims to retrace the influence of the politics of gender enacted by Nelson and Winnie Mandela on post-apartheid gender relationships, as represented in three novels: Phaswane Mpe’s Welcome to Our Hillbrow (2001, Njabulo Ndebele’s The Cry of Winnie Mandela (2003 and Lewis Nkosi’s Mandela’s Ego (2006. Recently, Nelson and Winnie Mandela’s marriage has been also described as the “unusual founding-family romance” (Munro 2014 of the post-apartheid nation. Their marriage lasted from 1958 to 1992, including, thus, the last decades of the anti-apartheid struggle, as well as the demise of the apartheid regime. Their separation, which was due in the first place to Nelson Mandela’s imprisonment and, later, to their divorce, eventually marked the disruption of this founding-family romance, making it “unusual”. As a consequence, the deconstructive take on Nelson Mandela’s fatherhood and masculinity and Winnie Mandela’s femininity and motherhood which is enacted in the three novels also allows to reassess the possibility of that “founding-family romance”, envisioning an alternative understanding of the origins of the post-apartheid South African nation.
John Nelson Darby: His Contributions to Evangelical Christian Higher Education

Science.gov (United States)

Sutherland, Winston Terrance

2010-01-01

The study reported in this article focused on the contributions of John Nelson Derby to biblical hermeneutics and contemporary eschatological thought. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of Darby's contributions to contemporary…
The struggle for Sunday lunch: gastropolitics in the life of Nelson Mandela.

Science.gov (United States)

Trapido, Anna

2011-01-01

This paper explores the political, economic, and social life of Nelson Mandela through his food choices from 1918 to the present. A description of the minutiae of one particular 1950s Sunday lunch is used to examine the broader role of first colonial and later apartheid legislation in determining the dietary choices and options of South Africans past and present. How such policies shaped attitudes and access to Nelson Mandela’s ancestral Xhosa cuisine is assessed. The long-term cultural, economic, and political impact of a lack of access to core indigenous African ingredients is evaluated. Most of all this paper offers a snapshot portrayal of two families (one white, one black) trying to sustain a normal friendship within a grossly abnormal society.

Setting up the Nelson Mandela centre of memory and commemoration

African Journals Online (AJOL)

This article aims to outline the process of the audits, highlight the issues involved in the development of the web archive, as well as provide details on the development of the database architecture. Keywords: centre of memory and commemoration, Constitution Hill Heritage Site, Nelson Mandela Foundation, South Africa
Remarks on an algebraic semantics for paraconsistent Nelson's logic

Directory of Open Access Journals (Sweden)

Manuela Busaniche

2011-06-01

Full Text Available In the paper Busaniche and Cignoli (2009 we presented a quasivariety of commutative residuated lattices, called NPc-lattices, that serves as an algebraic semantics for paraconsistent Nelson's logic. In the present paper we show that NPc-lattices form a subvariety of the variety of commutative residuated lattices, we study congruences of NPc-lattices and some subvarieties of NPc-lattices.
John Nelson Darby: Scholarship that Influenced the Bible College Movement

Science.gov (United States)

Sutherland, Winston Terrance

2010-01-01

The study reported in this article focused on the scholastic life of John Nelson Darby and his contributions to the Bible college movement. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of the forces that conspired to shape the direction of…
Special article: Horace Nelson MD, John Webster LDS--unrecognized Canadian anesthesia pioneers.

Science.gov (United States)

Craig, Douglas; Chartrand, Daniel

2014-03-01

The timing of the earliest reported ether anesthetics in early 1847, in regions to become Canada in July 1867, was examined using information from on-line and library-based sources. Previous authors had identified the first reported ether anesthetic given by a visiting American dentist in January 1847 in Saint John, New Brunswick. Nevertheless, they had reported three different anesthetics as the second occurrence - which would denote the first anesthetic given by a resident of Canada. We confirmed that there were no reports of ether anesthetics being given in Canada before that reported on January 18, 1847 in Saint John. The information available for our review indicates that the second ether anesthetic, and the first by a Canadian, was given in Montreal by a dentist, Dr. John Horatio Webster, on February 20, 1847. The surgical assistant for that operation, Dr. Horace Nelson, later reported on animal and human experiments with ether, which he had led in Montreal starting in January 1847. Earlier authors, who may not have had access to the information now available, came to incorrect conclusions about the first ether anesthetic reported to have been given by a Canadian. Current information indicates that John Webster gave the first reported anesthetic in Montreal on February 20, 1847 following experiments with ether led by Horace Nelson. Both Webster and Nelson deserve recognition as Canadian anesthesia pioneers.
Preliminary report on the Nelson and Radovan copper prospects, Nizina district, Alaska

Science.gov (United States)

Sainsbury, C.J.

1952-01-01

Renewed copper exploration by Alaska Copper Mines, Incorporated, at the Nelson and Radovan prospects, Nizina district, Alaska, led the Geological Survey in 1951 to map in detail the Nelson fault block, and to re-examine the old workings. In addition, two new prospects were studied. The Nelson fault block is cut by many dominantly strike-slip faults of small displacement, and by bedding faults. Slickensided chalcocite shows post-mineral movement, and chalcocite veinlet in a filled solution cavity indicates that some of the chalcocite is secondary, perhaps very recent. Structural relations indicate two overthrust faults cut the block. The Radovan Greenstone prospect shows massive chalcocite, up to 3 feet wide, in a silicified, epidotized fault zone in the Nikolai greenstone. Ore indicated by surface exposures may amount to 450 tons of chalcocite. The Radovan Low-Contact prospect is on a continuation of the same fault approximately 3 miles southwest of the Greenstone prospect, and 150 feet above the contact of the Nikolai greenstone and the overlying Chitistone limestone. Limonite staining is widespread in bedding planes and small faults near the fault zone; mineralization in the fault zone consists of pyrite, chalcocite, bornite, malachite, realgar, orpiment and stibnite. The sulphides in the fault zone, plus the widespread silicification and epidotization indicate a strong zone of hydrothermal activity which merits extensive prospecting.
Mixing and photoreactivity of dissolved organic matter in the Nelson/Hayes estuarine system (Hudson Bay, Canada)

Science.gov (United States)

Guéguen, C.; Mokhtar, M.; Perroud, A.; McCullough, G.; Papakyriakou, T.

2016-09-01

This work presents the results of a 4-year study (2009-2012) investigating the mixing and photoreactivity of dissolved organic matter (DOM) in the Nelson/Hayes estuary (Hudson Bay). Dissolved organic carbon (DOC), colored DOM, and humic-like DOM decreased with increasing salinity (r2 = 0.70-0.84). Removal of DOM was noticeable at low to mid salinity range, likely due to degradation and/or adsorption to particles. DOM photobleaching rates (i.e., decrease in DOM signal resulting from exposure to solar radiation) ranged from 0.005 to 0.030 h- 1, corresponding to half-lives of 4.9-9.9 days. Dissolved organic matter from the Nelson and Hayes Rivers was more photoreactive than from the estuary where the photodegradation of terrestrial DOM decreased with increasing salinity. Coincident with the loss of CDOM absorption was an increase in spectral slope S, suggesting a decrease in DOM molecular weight. Marked differences in photoreactivity of protein- and humic-like DOM were observed with highly humidified material being the most photosensitive. Information generated by our study will provide a valuable data set for better understanding the impacts of future hydroelectric development and climate change on DOM biogeochemical dynamics in the Nelson/Hayes estuary and coastal domain. This study will constitute a reference on terrestrial DOM fate prior to building additional generating capacity on the Nelson River.
A generalization of Fenyes-Nelson stochastic model of quantum mechanics

International Nuclear Information System (INIS)

Davidson, M.

1979-01-01

It is shown that the stochastic model of Fenyes and Nelson can be generalized in such a way that the diffusion constant of the Markov theory becomes a free parameter. This extra freedom allows one to identify quantum mechanics with a class of Markov processes with diffusion constants varying from 0 to infinity. (Auth.)
The Use of Titrimetric, Nelson Somogyi and Hplc Methods for the Analysis of Cashew Apple Juice Fermentation Broths

OpenAIRE

Kantasubrata, Julia; T. Karossi, A; S. Pramudi, A

1993-01-01

In cashew apple juice fermentation to produce wine and vinegar, analysis of organic acids and sugars in fermentation broths is very important, due to the fact that optimum conditions of fermentation could only be established from results obtained on monitoring the concentrations of those components during the fermentation process. Analysis of organic acids by tiirimetric method and analysis of sugars by Nelson-Somogyi method only give a total amount of acids and sugars. HPLC is one of the pro...
Romance and Freedom: Nelson and Winnie Mandela’s Politics of Gender in Three Post-Apartheid Novels

OpenAIRE

Mari, Lorenzo

2014-01-01

This paper aims to retrace the influence of the politics of gender enacted by Nelson and Winnie Mandela on post-apartheid gender relationships, as represented in three novels: Phaswane Mpe’s Welcome to Our Hillbrow (2001), Njabulo Ndebele’s The Cry of Winnie Mandela (2003) and Lewis Nkosi’s Mandela’s Ego (2006). Recently, Nelson and Winnie Mandela’s marriage has been also described as the “unusual founding-family romance” (Munro 2014) of the post-apartheid nation. Their marriage lasted fr...
Lung cancer screening in the NELSON trial: balancing harms and benefits

NARCIS (Netherlands)

N. Horeweg (Nanda)

2014-01-01

markdownabstract__Abstract__ In this thesis, the harms and benefits of lung cancer screening using low-dose computed tomography were investigated. Data of the Dutch-Belgian NELSON trial were used to quantify its harms and benefits and develop strategies to improve the balance between them. If the
77 FR 1667 - Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, Respondent...

Science.gov (United States)

2012-01-11

..., Rio De Janeiro, R.J., Brazil 20531-070, Respondent; Order Relating to Nelson S. Galgoul The Bureau of... entry of the Order, Nelson S. Galgoul, with a last known address of Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, and when acting for or on his behalf, his representatives, assigns...
Assessment of the Use of the Nelson Denny Reading Test.

Science.gov (United States)

Perkins, Dorothy

1984-01-01

The Nelson Denny Reading Test (NDRT) is probably the most widely used test of reading comprehension at the college level in the nation. However, reviews of the test, as well as recent reports of its failure to adequately measure gain or lack of gain of college students enrolled in reading improvement courses, do not support the popularity it has…
Silenced but Not Silent: The Rhetorical Influence of Nelson Mandela.

Science.gov (United States)

Boyd, Susy

In the epicenter of the political strife in South Africa is former African National Congress (ANC) leader Nelson Mandela. The ANC is considered to be the leading source of opposition to white rule in South Africa, and Mandela is one of the most revered and powerful figures to emerge from that organization. Incarcerated for over 25 years on charges…
Extension of Nelson's stochastic quantization to finite temperature using thermo field dynamics

International Nuclear Information System (INIS)

Kobayashi, K.; Yamanaka, Y.

2011-01-01

We present an extension of Nelson's stochastic quantum mechanics to finite temperature. Utilizing the formulation of Thermo Field Dynamics (TFD), we can show that Ito's stochastic equations for tilde and non-tilde particle positions reproduce the TFD-type Schroedinger equation which is equivalent to the Liouville-von Neumann equation. In our formalism, the drift terms in the Ito's stochastic equation have the temperature dependence and the thermal fluctuation is induced through the correlation of the non-tilde and tilde particles. We show that our formalism satisfies the position-momentum uncertainty relation at finite temperature. -- Highlights: → Utilizing TFD, we extend Nelson's stochastic method to finite temperature. → We introduce stochastic equations for tilde and non-tilde particles. → Our stochastic equations can reproduce the TFD-type Schroedinger equation. → Our formalism satisfies the uncertainly relation at finite temperature.
Application of the Nelson model to four timelag fuel classes using Oklahoma field observations: Model evaluation and comparison with national Fire Danger Rating System algorithms

Science.gov (United States)

J. D. Carlson; Larry S. Bradshaw; Ralph M. Nelson; Randall R Bensch; Rafal Jabrzemski

2007-01-01

The application of a next-generation dead-fuel moisture model, the 'Nelson model', to four timelag fuel classes using an extensive 21-month dataset of dead-fuel moisture observations is described. Developed by Ralph Nelson in the 1990s, the Nelson model is a dead-fuel moisture model designed to take advantage of frequent automated weather observations....
Cointegration analysis of the dynamic Nelson-Siegel model using the wild bootstrap

NARCIS (Netherlands)

Boswijk, H.P.

2013-01-01

The Dynamic Nelson-Siegel model describes the evolution over time of the term structure of interest rates in terms of three factors, characterising the level, slope and curvature of the yield curve. This article uses recently developed cointegration techniques for heteroskedastic time series to
Figural properties are prioritized for search under conditions of uncertainty: Setting boundary conditions on claims that figures automatically attract attention.

Science.gov (United States)

Peterson, Mary A; Mojica, Andrew J; Salvagio, Elizabeth; Kimchi, Ruth

2017-01-01

Nelson and Palmer (2007) concluded that figures/figural properties automatically attract attention, after they found that participants were faster to detect/discriminate targets appearing where a portion of a familiar object was suggested in an otherwise ambiguous display. We investigated whether these effects are truly automatic and whether they generalize to another figural property-convexity. We found that Nelson and Palmer's results do generalize to convexity, but only when participants are uncertain regarding when and where the target will appear. Dependence on uncertainty regarding target location/timing was also observed for familiarity. Thus, although we could replicate and extend Nelson and Palmer's results, our experiments showed that figures do not automatically draw attention. In addition, our research went beyond Nelson and Palmer's, in that we were able to separate figural properties from perceived figures. Because figural properties are regularities that predict where objects lie in the visual field, our results join other evidence that regularities in the environment can attract attention. More generally, our results are consistent with Bayesian theories in which priors are given more weight under conditions of uncertainty.
Tunneling time distribution by means of Nelson's quantum mechanics and wave-particle duality

International Nuclear Information System (INIS)

Hara, Koh'ichiro; Ohba, Ichiro

2003-01-01

We calculate a tunneling time distribution by means of Nelson's quantum mechanics and investigate its statistical properties. The relationship between the average and deviation of tunneling time suggests the existence of 'wave-particle duality' in the tunneling phenomena
‘Magic Negro’, Saint or Comrade: Representations of Nelson Mandela in Film

Directory of Open Access Journals (Sweden)

Roger Bromley

2014-11-01

Full Text Available “In the late 1980s, Nelson Mandela stood alone against the apartheid state.” This comment taken from the DVD Box set cover of Nelson Mandela: From Freedom to History summarises the approach taken by many of the cinematic and televisual representations of Mandela. Linked with this is a statement by the CEO of Marriott which speaks of Mandela as “an individual who changed the arc of history through his or her singular contribution, not as a function of the era or the movement but because of what they did alone.” Together, these descriptions attempt to appropriate Mandela for a sanitised version of western individualism which sees him variously as a liberal icon, saintly hero, or the celebrity one-off “magic negro”, in Okwongo’s damning phrase taken from his magisterial valedictory piece “Mandela will never, ever be your minstrel” (Okwongo 2013. In the process, Mandela’s role in the anti-apartheid...
Canavan disease

Science.gov (United States)

... affects how the body breaks down and uses aspartic acid . ... scan Head MRI scan Urine chemistry for elevated aspartic acid ... Matalon KM, Matalon RK. Aspartic acid (Canavan disease). In: ... JW III, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. ...

Nelson River and Hudson Bay

Science.gov (United States)

2002-01-01

Rivers that empty into large bodies of water can have a significant impact on the thawing of nearshore winter ice. This true-color Moderate Resolution Imaging Spectroradiometer (MODIS) image from May 18, 2001, shows the Nelson River emptying spring runoff from the Manitoba province to the south into the southwestern corner of Canada's Hudson Bay. The warmer waters from more southern latitudes hasten melting of ice near the shore, though some still remained, perhaps because in shallow coastal waters, the ice could have been anchored to the bottom. High volumes of sediment in the runoff turned the inflow brown, and the rim of the retreating ice has taken on a dirty appearance even far to the east of the river's entrance into the Bay. The sediment would have further hastened the melting of the ice because its darker color would have absorbed more solar radiation than cleaner, whiter ice. Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC
Relativism: Protagoras and Nelson Goodman

Directory of Open Access Journals (Sweden)

Esmaeil Saadati Khamseh

2015-12-01

Full Text Available Discussion of the many faces of relativism occupies a highly prominent place in the epistemological literature. Protagoras in ancient Greece and Nelson Goodman in the modern period are two most notable proponent of relativism. In the present article, I discuss and explain relativistic approaches of this two important relativist. I will first briefly define and review some faces of relativism. Then I will discuss and elaborate Protagorean or true-for-me relativism and Goodman’s radical relativism in turn. I will argue that there are crucial difficulties in Protagorean and radical relativism, and that these difficulties, as the realist philosophers insist, make these two faces of relativism be undefensible. No doubt, these two shapes of relativism have paved the way for anti-realism. In the end, it will appear that Goodman’s radical relativism and so the theory of worldmaking, like Protagorean relativism, suffers from a fatal flaw: the flaw of self-refuting.
A report on the fisheries resources of the lower Nelson River and the impacts of hydroelectric development, 1988 data

International Nuclear Information System (INIS)

Swanson, G.M.; Kansas, K.R.; Matkowski, S.M.

1990-01-01

Fisheries studies on the lower Nelson River (Manitoba) system have had the goals of gaining an understanding of the fisheries resources present, assessing current and potential impacts of hydroelectric developments, and investigating enhancement or mitigative options. In 1988, a resource inventory of McMillan and 12-Mile Creeks was conducted to increase understanding of brook trout stocks in the Limestone River system. Results indicate that both streams contain self-sustaining populations. Baseline data collection in the Conawapa Forebay of the Nelson River was initiated in 1988. Inventories of fish populations were conducted, focusing on lake sturgeon. Three long-term monitoring projects were continued in 1988, investigating the populations of spawning brook trout, larval brook trout, and anadromy in brook trout. Four major tributaries to the Nelson River were classified on the basis of physical and chemical characteristics in an attempt to understand brook trout distribution patterns. Ten sturgeon were captured in Angling Lake in 1988 and fitted with radio tags to assess the importance of the Angling Lake-Angling River system to Nelson River lake sturgeon. To investigate the feasibility of enhancing brook trout populations in the Nelson River system, baskets of eggs were planted in previously identified spawning areas in three creeks in 1988. The eggs developed and hatched only in CN Creek. The potential for rehabilitating the Kettle River brook trout population by transfer of fish from other rivers was also investigated in 1988. Radio-tagged fish remained in the Kettle River-Long Spruce system throughout the life of the tags and appear to have found suitable summer and winter habitat. 60 refs., 76 figs., 38 tabs
Celebrating the Hero in All of Us: An Interview with Kadir Nelson

Science.gov (United States)

Sableski, Mary-Kate; Arnold, Jackie Marshall; Adomat, Donna Sayers

2015-01-01

Books provide an opportunity through which children can learn what it means to be in the world and to respond flexibly and creatively to a diverse range of situations. Author/illustrator Kadir Nelson creates books that provide these opportunities for readers of all ages. A dominant theme in current conversations surrounding children's literature…
Characterization of mercury and its risk in Nelson's, Saltmarsh, and Seaside Sparrows.

Directory of Open Access Journals (Sweden)

Virginia L Winder

Full Text Available BACKGROUND: Nelson's, Saltmarsh, and Seaside Sparrows (Ammodramus nelsoni, A. caudacutus, and A. maritimus, respectively depend on marsh and wetland habitats--ecosystems in which mercury (Hg bioavailability is notoriously high. The purpose of the present study was to address the potential impact of Hg on these species using first primary and breast feathers as non-destructive biomonitoring tools. METHODS AND PRINCIPAL FINDINGS: Feathers were sampled from wintering sparrows in North Carolina salt marshes (2006-2010. Feather Hg data were used in three risk analysis components (1 Threshold Component--examined feather Hg with regard to published negative effects thresholds; (2 Hg Dynamics Component--examined Hg in sparrows captured multiple times; and (3 Capture Frequency and Survival Component--tested for links between Hg and return frequency and survival. Threshold Component analyses indicated that Hg concentrations in 42-77% of sampled individuals (breast feather n = 879; first primary feather n = 663 were within the range associated with decreased reproduction in other avian species. Hg Dynamics Component analyses demonstrated that Hg increased between first and second captures for Nelson's (n = 9 and Seaside Sparrows (n = 23. Capture Frequency and Survival Component analyses detected a negative relationship between Hg and capture frequency in Nelson's Sparrows (n = 315. However, MARK models detected no effect of Hg on apparent survival in any species. CONCLUSION AND SIGNIFICANCE: This study indicates that current Hg exposure places a considerable proportion of each population at risk. In particular, 52% of all sampled Saltmarsh Sparrows exhibited first primary feather Hg concentrations exceeding those associated with a >60% reduction in reproductive success in other species. This study reports evidence for net annual bioaccumulation, indicating an increased risk in older individuals. These data can be used to inform future population
Characterization of mercury and its risk in Nelson's, Saltmarsh, and Seaside Sparrows.

Science.gov (United States)

Winder, Virginia L

2012-01-01

Nelson's, Saltmarsh, and Seaside Sparrows (Ammodramus nelsoni, A. caudacutus, and A. maritimus, respectively) depend on marsh and wetland habitats--ecosystems in which mercury (Hg) bioavailability is notoriously high. The purpose of the present study was to address the potential impact of Hg on these species using first primary and breast feathers as non-destructive biomonitoring tools. Feathers were sampled from wintering sparrows in North Carolina salt marshes (2006-2010). Feather Hg data were used in three risk analysis components (1) Threshold Component--examined feather Hg with regard to published negative effects thresholds; (2) Hg Dynamics Component--examined Hg in sparrows captured multiple times; and (3) Capture Frequency and Survival Component--tested for links between Hg and return frequency and survival. Threshold Component analyses indicated that Hg concentrations in 42-77% of sampled individuals (breast feather n = 879; first primary feather n = 663) were within the range associated with decreased reproduction in other avian species. Hg Dynamics Component analyses demonstrated that Hg increased between first and second captures for Nelson's (n = 9) and Seaside Sparrows (n = 23). Capture Frequency and Survival Component analyses detected a negative relationship between Hg and capture frequency in Nelson's Sparrows (n = 315). However, MARK models detected no effect of Hg on apparent survival in any species. This study indicates that current Hg exposure places a considerable proportion of each population at risk. In particular, 52% of all sampled Saltmarsh Sparrows exhibited first primary feather Hg concentrations exceeding those associated with a >60% reduction in reproductive success in other species. This study reports evidence for net annual bioaccumulation, indicating an increased risk in older individuals. These data can be used to inform future population assessments and management for these species.
Crecimiento en clavel estándar cv. Nelson, en suelo y en sustratos Crescimento de cravo estandar cv. Nelson, em solo e em substratos Growth of standard carnation cv. Nelson, in soil and substrates

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Adriana Del Pilar Baracaldo Argüello

2010-01-01

colheita. No SENA - Centro Multisetorial de Mosquera, plantas de cravo foram submetidas aos seguintes tratamentos: 100% de casca de arroz queimada; 65% casca de arroz queimada - 35% fibra de coco; 35% casca de arroz queimada - 65% fibra de coco, e solo. Em amostragens contínuas foram avaliadas as variáveis número de folhas, comprimento, diâmetro e número de nós do caule, e diâmetro e comprimento do botão floral e se ajustaram curvas de crescimento. Em plantas cultivadas em solo observou-se maior número de hastes. Nese tratamento também ocorreu maior número de nós e de folhas nas hastes florais, que no entanto, foram mais curtas. Além disso, notaram-se menor diâmetro de caule e menor comprimento e diâmetro do botão floral, características determinantes da qualidade. Portanto, a produção de hastes exportáveis do tipo "select" foi significativamente inferior no cultivo em solo, em comparação com os demais tratamentos.The production of carnation cut flowers in the Bogotá plateau has been important in the last decades, bringing them to second place in the total of Colombian cut flowers exports. Recently, due to pathogenic diseases, this crop is grown using soil-less techniques, particularly on organic substrates. For this reason, it is important to investigate the growth of carnation plants in such conditions. The aim of this research was to evaluate the growth of standard carnation cv. Nelson grown both in soil and substrates, in the second harvest peak of production. For that purpose, in the SENA - Multisectorial Center of the municipality of Mosquera, rooted cuttings were transplanted into the following substrates and mixes: 100% burnt rice husk; 65% burnt rice husk-35% coconut fiber; 35% burnt rice husk-65% coconut fiber and soil, reflecting the treatments to be analyzed. Through continuous sampling, the variables leaves number, length and diameter of flowering stem, nodes number, and length and diameter of floral bud were evaluated. The data were
A comparison of the value of MRI and CT in patients with Nelson syndrome

International Nuclear Information System (INIS)

Kersjes, W.; Allmendinger, S.; Christ, F.; Stiebler, H.; Bockisch, A.; Klingmueller, D.

1992-01-01

The hypophyses of 13 patients with Nelson syndrome following bilateral adrenalectomy were examined by MRI and CT. Diffuse enlargement of the hypophysis was demonstrated in 8 patients by CT and in 9 by MRI. Compared with CT, MRI provides better demonstration of tumour development, such as abnormal convexity of the cranial margin of the hypophysis (MRI 4/13, CT 1/13), displacement of the infundibulum (MRI 4/13, CT 0/13) or optic chiasm (MRI 2/13, CT 0/13). MRI also provides diagnostically important differentiation between scar tissue and recurrence of tumour following hypophysectomy (MRI 1/3, CT 0/3) and more accurate demonstration of infiltration of the cavernous sinus (MRI 4/13, CT 2/13). CT is superior only in showing the floor of the sella. MRI is the method of choice for imaging in cases of Nelson syndrome. (orig.) [de
The generalized Fenyes-Nelson model for free scalar field theory

International Nuclear Information System (INIS)

Davidson, M.

1980-01-01

The generalized Fenyes-Nelson model of quantum mechanics is applied to the free scalar field. The resulting Markov field is equivalent to the Euclidean Markov field with the times scaled by a common factor which depends on the diffusion parameter. This result is consistent with Guerra's earlier work on stochastic quantization of scalar fields. It suggests a deep connection between Euclidean field theory and the stochastic interpretation of quantum mechanics. The question of Lorentz covariance is also discussed. (orig.)
A rotated Dynamic Nelson-Siegel model with macro-financial applications

OpenAIRE

Nyholm, Ken

2015-01-01

A factor rotation scheme is applied to the well-known Dynamic Nelson-Siegel model facilitating direct parametrization of the short rate process. The model-implied term structure of term premia is derived in closed-form, and macroeconomic variables are included in a Taylor-rule- type fashion. Four empirical experiments are performed on US data covering the period from 1990 to 2014. It is found that macroeconomic variables impact the evolution of the short rate until 2002, after which their eff...
Social Justice and Human Rights in Education Policy Discourse: Assessing Nelson Mandela's Legacy

Science.gov (United States)

Gebremedhin, Abrehet; Joshi, Devin

2016-01-01

Twenty years after South Africa's democratisation, Nelson Mandela's passing has prompted scholars to examine his legacy in various domains. Here we take a look at his legacy in education discourse. Tracing Mandela's thoughts and pronouncements on education we find two major emphases: a view of education as a practical means to economic…
Failure Analysis of Main Flame Deflector Nelson Studs

Science.gov (United States)

Long, Victoria

2009-01-01

NASA Structures engineers submitted two Nelson refractory studs from the main flame deflector at Launch Complex (LC) 39 A for analysis when they were observed to be missing a significant amount of material after launch. The damaged stud and an unused comparative stud were analyzed by macroscopic and microscopic examination along with metallographic evaluation of the microstructure. The stud lost material due to a combination of erosion and corrosion. Plain carbon steel readily forms an oxide layer in the coastal launch environment at Kennedy Space Center. The blast during a launch removes this brittle oxide layer, which then forms again post-launch, thereby further removing material. No indications of melting were observed.
A hermeneutical reading of Penrose and Nelson and Winter-Tracing origins of a misunderstanding?

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Dr. Oliver Krone

2010-05-01

Full Text Available This paper aims to understand based on a hermeutical reading of Penrose (1959 and Nelson and Winter (1982 what knowledge is and where it is stored in the respective authors. Furthermore, the author wants to learn whether the subsumtion of Knowledge Integration to Knowledge Management, as it can be often in the literature, has any foundation when coming from these authors. Reason for this overall analysis is the widely held view in the discipline of Knowledge Management that these authors are forefathers for it. Based on an interpretative, qualitative approach the author examines the way in which knowledge is held and created within organisations in the main work of this pair of author. The author comes to the conclusion that the discipline of Knowledge Management has seemingly overemphasised certain elements in the work of Penrose and Nelson and Winter, while neglecting the key aspect that for both author(s the act of Knowledge Integration is much rather described in these works.
The Weathered Corrugations of His Face: A Performative Reflection on Nelson Mandela, Self, and the Call for Racial (UnBecoming

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Paul Badenhorst

2015-03-01

Full Text Available On the occasion of the first anniversary of the death of Nelson Rolihlahla MANDELA, this self-exploratory narrative study utilizes a Butlerian performative theoretical framework to both uncover discursively regulated social practices as generative of raced identity ensconced in belonging, and the undoing of such identity through the redeployment of social practices predicated instead on a Weltanschauung of becoming. While the accountable subject of autoethnographic work is concomitantly problematized, fluid subjectivity is itself demonstrated as crucial to historical accountability. A resultant appeal for white South Africans to actively begin the work of defamiliarizing themselves with the sanitized dominant popular culture representation of the peace icon, this research ultimately calls for new existential reflection upon the face of Nelson MANDELA so as to begin uncovering its deeper historical significance, contemporary relevance, and the future ethical imperative it demands of those who come from a liminal position of, as J.M. COETZEE once wrote, "no longer European, not yet African" (1988, p.11. In short, it is argued that white South Africans need to move from a condition of belonging predicated on raced identity to one of transracial—and even interracial—African becoming. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs150223
Hydrology signal from GRACE gravity data in the Nelson River basin, Canada: a comparison of two approaches

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Li, Tanghua; Wu, Patrick; Wang, Hansheng; Jia, Lulu; Steffen, Holger

2018-03-01

The Gravity Recovery and Climate Experiment (GRACE) satellite mission measures the combined gravity signal of several overlapping processes. A common approach to separate the hydrological signal in previous ice-covered regions is to apply numerical models to simulate the glacial isostatic adjustment (GIA) signals related to the vanished ice load and then remove them from the observed GRACE data. However, the results of this method are strongly affected by the uncertainties of the ice and viscosity models of GIA. To avoid this, Wang et al. (Nat Geosci 6(1):38-42, 2013. https://doi.org/10.1038/NGEO1652; Geodesy Geodyn 6(4):267-273, 2015) followed the theory of Wahr et al. (Geophys Res Lett 22(8):977-980, 1995) and isolated water storage changes from GRACE in North America and Scandinavia with the help of Global Positioning System (GPS) data. Lambert et al. (Postglacial rebound and total water storage variations in the Nelson River drainage basin: a gravity GPS Study, Geological Survey of Canada Open File, 7317, 2013a, Geophys Res Lett 40(23):6118-6122, https://doi.org/10.1002/2013GL057973, 2013b) did a similar study for the Nelson River basin in North America but applying GPS and absolute gravity measurements. However, the results of the two studies in the Nelson River basin differ largely, especially for the magnitude of the hydrology signal which differs about 35%. Through detailed comparison and analysis of the input data, data post-processing techniques, methods and results of these two works, we find that the different GRACE data post-processing techniques may lead to this difference. Also the GRACE input has a larger effect on the hydrology signal amplitude than the GPS input in the Nelson River basin due to the relatively small uplift signal in this region. Meanwhile, the influence of the value of α , which represents the ratio between GIA-induced uplift rate and GIA-induced gravity-rate-of-change (before the correction for surface uplift), is more obvious in
Nelson Mandela's defence: A psychological capital documentary analysis

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Rene van Wyk

2014-11-01

Full Text Available This qualitative documentary analysis examines Nelson Mandela�s defence statement at the Rivonia Trial, Pretoria Supreme Court, on 20 April 1964. The defence document is analysed through the psychological capital lens, depicting themes that support the constructs of hope, efficacy, resilience and optimism. Psychological capital characteristics played a major role in the initial non-violent policies of negotiation. The inevitable establishment of Umkhonto we Sizwe followed, as a result of the increased restrictions and unwillingness of government to negotiate and collaborate. Mandela showed a determined spirit to unite the country. The discussion gives insight into Mandela�s authentic psychological capital leadership under difficult political and personal circumstances. Some implications are indicated in adopting Mandela�s psychological characteristics for personal reform.
Uniform product formulae with application to the Feynman-Nelson integral for open systems

International Nuclear Information System (INIS)

Exner, P.; Kolerov, G.I.

1982-01-01

The product formula for perturbations of propagators by Faris is generalized: we show that one can use arbitrary partitions of a given interval and perform the limit uniformly with respect to the partition norm. The results are applied to express solutions of the Schroedinger equation, in particular for some complex and time-dependent potentials, by means of Nelson-type path integrals. (orig.)
PERBANDINGAN METODE SOMOGYI-NELSON DAN ANTHRONE-SULFAT PADA PENETAPAN KADAR GULA PEREDUKSI DALAM UMBI CILEMBU (Ipomea batatas L.

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Hasanul Kiyan Al-kayyis

2016-11-01

Full Text Available Sweet potato cultivar Cilembu, kind of ‘rancing’ from Cilembu Village, Sumedang, West Java has really sweet taste due to the high content of reducing sugar. The amount of reducing sugar needs to be proven scientifically. The study aimed to compare Somogyi-Nelson method and Anthrone-Sulfate method in order to determine reducing sugar level in Cilembu sweet potato. Cilembu sweet potato must be stored in freezer at 15°C for 2 weeks before used as the sample. Analytical method validation was performed for the two methods. The determination results between two methods were compared. The amount of reduction sugar (glucose from Cilembu sweet potato determined by Somogyi-Nelson method was 3.42%, the value of %recovery was 99.8%, LOD = 0.00167 (mg/mL, LOQ = 0.00557 (mg/mL, and value of RSD was 3.7%. While the average amount of reduction sugar determined by Anthrone-Sulfate method was 14.9%, the value of %recovery was 74.7%, LOD = 0.0198 (mg/mL, LOQ = 0.066 (mg/mL, and value of RSD = 8.6%. The Somogyi-Nelson method was more recommended for the analysis of the reducing sugar in Cilembu sweet potato compared with Anthrone-Sulfate method.
Passageless Comprehension on the "Nelson-Denny Reading Test": Well above Chance for University Students

Science.gov (United States)

Coleman, Chris; Lindstrom, Jennifer; Nelson, Jason; Lindstrom, William; Gregg, K. Noel

2010-01-01

The comprehension section of the "Nelson-Denny Reading Test" (NDRT) is widely used to assess the reading comprehension skills of adolescents and adults in the United States. In this study, the authors explored the content validity of the NDRT Comprehension Test (Forms G and H) by asking university students (with and without at-risk…
Nelson's stochastic quantization of free linearized gravitational field and its Markovian structure

International Nuclear Information System (INIS)

Lim, S.C.

1983-05-01

It is shown that by applying Nelson's stochastic quantization scheme to free linearized gravitational field tensor one can associate with the resulting stochastic system a stochastic tensor field which coincides with the ''space'' part of the Riemannian tensor in Euclidean space-time. However, such a stochastic field fails to satisfy the Markov property. Instead, it satisfies the reflection positivity. The Markovian structure of the stochastic fields associated with the electromagnetic field is also discussed. (author)

Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers.

Science.gov (United States)

Horeweg, Nanda; Scholten, Ernst Th; de Jong, Pim A; van der Aalst, Carlijn M; Weenink, Carla; Lammers, Jan-Willem J; Nackaerts, Kristiaan; Vliegenthart, Rozemarijn; ten Haaf, Kevin; Yousaf-Khan, Uraujh A; Heuvelmans, Marjolein A; Thunnissen, Erik; Oudkerk, Matthijs; Mali, Willem; de Koning, Harry J

2014-11-01

Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and others can develop in the interval between screens. The NELSON trial is a randomised trial to assess the effect of screening with increasing screening intervals on lung cancer mortality. In this prespecified analysis, we aimed to assess screening test performance, and the epidemiological, radiological, and clinical characteristics of interval cancers in NELSON trial participants assigned to the screening group. Eligible participants in the NELSON trial were those aged 50-75 years, who had smoked 15 or more cigarettes per day for more than 25 years or ten or more cigarettes for more than 30 years, and were still smoking or had quit less than 10 years ago. We included all participants assigned to the screening group who had attended at least one round of screening. Screening test results were based on volumetry using a two-step approach. Initially, screening test results were classified as negative, indeterminate, or positive based on nodule presence and volume. Subsequently, participants with an initial indeterminate result underwent follow-up screening to classify their final screening test result as negative or positive, based on nodule volume doubling time. We obtained information about all lung cancer diagnoses made during the first three rounds of screening, plus an additional 2 years of follow-up from the national cancer registry. We determined epidemiological, radiological, participant, and tumour characteristics by reassessing medical files, screening CTs, and clinical CTs. The NELSON trial is registered at www.trialregister.nl, number ISRCTN63545820. 15,822 participants were enrolled in the NELSON trial, of whom 7915 were assigned to low-dose CT screening with increasing interval between screens, and 7907 to no screening. We included 7155 participants in our study, with
Comments on the note by L.S. Nelson: ''unusually high (oxidizer/Pu) ratios in the macro-residues from plutonium droplet combustion''

International Nuclear Information System (INIS)

Allen, M.D.; Morgan, L.G.

1982-01-01

An alternative explanation for unusually high ratios of oxidizers/plutonium in the residues from plutonium droplet combustion is offered in response to a note by L.S. Nelson. Two additional experiments are suggested that would be helpful in clarifying the high oxidizer/Pu ratios. The first would be to measure the true surface area for a spherule after its explosion. The second is an experiment analogous to a gas analysis experiment. The conclusion is put forth that adsorbed gases are the most likely cause of the high O/M ratios described by Nelson
Adaptation of the Nelson-Somogyi reducing-sugar assay to a microassay using microtiter plates.

Science.gov (United States)

Green, F; Clausen, C A; Highley, T L

1989-11-01

The Nelson-Somogyi assay for reducing sugars was adapted to microtiter plates. The primary advantages of this modified assay are (i) smaller sample and reagent volumes, (ii) elimination of boiling and filtration steps, (iii) automated measurement with a dual-wavelength scanning TLC densitometer, (iv) increased range and reproducibility, and (v) automated colorimetric readings by reflectance rather than absorbance.
Construção de curva de juros de debêntures no mercado brasileiro utilizando a parametrização de Nelson-Siegel Construcción de curva de tipo de interés de bonos en el mercado brasileño mediante la parametrización de Nelson-Siegel Constructing the yield curve for Brazilian debentures using Nelson-Siegel parameterization

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Vinícius Gomes Araújo

2013-03-01

Full Text Available O objetivo nesse trabalho é a construção da Estrutura a Termo de Taxa de Juros (ETTJ das debêntures que se encontram disponíveis no mercado brasileiro, usando o modelo Nelson-Siegel (1987. As curvas de juros são divididas de acordo com o tipo de indexador e com a classificação de risco atribuída às debêntures. Por fim, foi possível mensurar o spread que existe entre o mercado de títulos privados (debêntures e os títulos públicos.El objetivo en este trabajo es determinar la estructura temporal de tipos de interés (ETTI de los bonos que se encuentran disponibles en el mercado brasileño, por medio del uso del modelo de Nelson-Siegel (1987. Las curvas de rendimientos fueron divididas de acuerdo con el tipo de índice y con la clasificación de riesgo atribuida a los bonos. Fue posible medir el spread entre el mercado de bonos corporativos (debentures y el mercado de los títulos del Estado.The aim of this work is to establish a term structure of interest rates for corporate bonds in the Brazilian market, using the Nelson-Siegel model (1987. The yield curves were divided by the type of index and the rating level. It was possible to measure the spread between the corporate bonds market and the government bonds market.
A personal experience in the presence of a man who transformed a nation and changed the world: Nelson Mandela.

Science.gov (United States)

Brown, Geraldine

2014-01-01

At this time in history, I consider myself very privileged to have spent some three hours in the presence of President Nelson Mandela as a Howard University faculty member in the late 1990s. Then, President of Howard University, H. Patrick Swygert bestowed upon President Nelson Mandela, Esquire an Honorary Doctorate of Human Letters. I can only equate this experience to my four mile walk up the Bedaling Wall (Great Wall) in China (a magnificent ancient wonder of the world), and trying to relate this event to something only fortunate souls have had the chance to enjoy. I also treasure the once in a lifetime visit to the Republic of South Africa in 1998 when the Association of Black Nursing Faculty, Inc., Chi Eta Phi Nursing Sorority, Inc., and the Department of Nursing (University of Botswana) sponsored the trip as an attempt to establish partnerships, share common interests and discussion in how to meet health needs of emerging majority and disadvantaged populations in the world, including mainly, the continent of Africa, in the 21st century. This short memoir can only piggy-back the massive coverage in the media that began almost instantly as a long anticipated event (death of Nelson Mandela), but startled upon its occurrence.
Representation theory of Lie-admissible enveloping algebras on operator algebras: an extension of a theorem by Nelson

International Nuclear Information System (INIS)

Ghikas, D.K.P.; Ktorides, C.N.; Papaloukas, L.

1980-01-01

This mathematical note is motivated by an assessment concerning our current understanding of the role of Lie-admissible symmetries in connection with quantum structures. We identify the problem of representations of the universal enveloping (lambda, μ)-mutation algebra of a given Lie algebra on a suitable algebra of operators, as constituting a fundamental first step for improving the situation. We acknowledge a number of difficulties which are peculiar to the adopted nonassociative product for the operator algebra. In view of these difficulties, we are presently content in establishing the generalization, to the Lie-admissible case, of a certain theorem by Nelson. This theorem has been very instrumental in Nelson's treatment concerning the Lie symmetry content of quantum structures. It is hoped that a similar situation will eventually prevail for the Lie-admissible case. We offer a number of relevant suggestions
"Passageless" Administration of the Nelson-Denny Reading Comprehension Test: Associations with IQ and Reading Skills

Science.gov (United States)

Ready, Rebecca E.; Chaudhry, Maheen F.; Schatz, Kelly C.; Strazzullo, Sarah

2013-01-01

There are few tests that assess reading comprehension in adults, but these tests are needed for a comprehensive assessment of reading disorders (RD). "The Nelson-Denny Reading Test" (NDRT) has a long-passage reading comprehension component that can be used with adolescents and adults. A problem with the NDRT is that reading comprehension…
On the Reconciliation of the Extended Nelson-Siegel and the Extended Vasicek Models (with a View Towards Swap and Swaption Valuation)

DEFF Research Database (Denmark)

Jørgensen, Peter Løchte

Extended Nelson-Siegel models are widely used by e.g. practitioners and central banks to estimate current term structures of riskless zero-coupon interest rates, whereas other models such as the extended Vasicek model (a.k.a. the Hull-White model) are popular for pricing interest rate derivatives....... This paper establishes theoretical consistency between these two types of models by showing how to specify the extended Vasicek model such that its implied initial term structure curve precisely matches a given extended Nelson-Siegel specification. That is, we show how to reconcile the two classes of models...
Shaping Influences on the Leadership of Genghis Khan, George Washington, and Nelson Mandela: Applications for Educators

Science.gov (United States)

Bongila, Jean-Pierre

2011-01-01

Using a prosopographical methodology this study examines common leadership influences that might have existed among Genghis Khan, George Washington, and Nelson Mandela. Shoup (2005) suggests that the following seven influences have contributed to nurturing the leadership of 12 renowned individuals: involved parents, happy childhood, formal,…
Coherent Backscattering: Conceptions and Misconceptions (Reply to Comments by Bruce W. Hapke and Robert M. Nelson)

Science.gov (United States)

Tishkovets, Victor P.; Mishchenko, Michael

2010-01-01

Although the note by Hapke and Nelson has virtually no relevance to our original publication, it contains a number of statements that are misleading and/or wrong. We, therefore, use this opportunity to dispel several profound misconceptions that continue to hinder the progress in remote sensing of planetary surfaces.
Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection

Science.gov (United States)

Brookfield, Stephen

2008-01-01

Nelson Mandela's autobiography "The Long Walk to Freedom" describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on…
Nelson Rodrigues e o Rio de Janeiro: memórias de um passional

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Ângela Maria Dias

2005-06-01

Full Text Available A crônica de Nelson Rodrigues, ao ser escrita do ponto de vista do homem comum - no diapasão do "pobre-diabo de um terno só" -, propicia a fundação de uma voz fronteiriça, entre o banal e o singular, e realiza a profissão de fé antiintelectualista e anti-retórica, característica da obra em suas diversas modalidades. A cidade do Rio de Janeiro, vitrine do Brasil durante as décadas de 1960 e 1970, constitui o protagonista do texto e opera a linguagem de modo a recriar seus espaços. O artista desdobra a sua imaginação totalizante em opostas e simétricas dimensões, a pornográfica e a mística, ou a do erotômano e a do "convertido". A dramatização pública do "reacionário" constitui, então, a resposta ritualística e sacrificial ao "revolucionário de esquerda" dos anos 1960, na prática renovada das formas totalizantes de pensamento.La crónica de Nelson Rodrigues, escrita del punto de vista del hombre común - en el disyuntiva del "pobre-hombre de traje único" - propicia la fundación de una voz fronteriza, entre lo banal y lo singular, y realiza la profesión de fé antiintelectualista y antirretórica, característica de la obra, en sus diversas modalidades. Rio de Janeiro, ciudad escaparate de Brasil durante las décadas de los 60 y 70, constituye el protagonista del texto y opera el lenguaje de modo a recriar sus espacios. El artista desdobla su imaginación totalizante en opuestas y simétricas dimensiones, la pornográfica y la mística, o la del erotómano y la del "convertido". La dramatización pública del "reacccionario" constituye, entonces, la respuesta del ritual y del sacrifício al "revolucionario de izquierda" de los años 60, en la práctica renovada de las formas totalizantes de pensamiento.Written from the point of view of the common man, Nelson Rodrigues' chronicle founds a bordering voice between the trivial and the singular and realizes an antiintellectualistic profession of faith. The city of Rio de
77 FR 42327 - Proposed Supplementary Rules for the Morley Nelson Snake River Birds of Prey National...

Science.gov (United States)

2012-07-18

... a BLM-approved metal fire ring. On BLM-administered public land within the Morley Nelson Snake River... located on improved campsites within BLM-approved metal fire rings on all lands administered by the BLM... fires outside of BLM-approved fire rings would help avert human-caused wildfire which would protect...
A DIPLOMACIA DE PRESTÍGIO NA ÁFRICA DO SUL DE NELSON MANDELA (1994-1999

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Pedro Vinícius Pereira Brites

2017-09-01

Full Text Available O presente estudo tem como objetivo analisar a política externa do governo Nelson Mandela na esteira de uma nova estrutura internacional pós-Guerra Fria, no período de 1994 a 1999, mapeando os atores envolvidos neste meio e os indicadores e variáveis que condicionavam a política externa do país.
Late Quaternary pollen records from the Lower Cobb Valley and adjacent areas, north-west Nelson, New Zealand

International Nuclear Information System (INIS)

Shulmeister, J.; McLea, W.L.; Singer, C.; McKay, R.M.; Hosie, C.

2003-01-01

Ten pollen records from the Cobb Valley and adjacent areas in North-West Nelson are described. Collectively they provide a vegetation record extending from the Last Glacial Maximum to the present day. During the Last Glacial Maximum the uplands of North-West Nelson were glaciated. By about 17,000 radiocarbon years BP ice had retreated some distance up the Cobb River Valley and a podocarp heath and tussockland vegetation covered non-glaciated areas. By 14,000 radiocarbon years BP, the valley floor and adjacent lower ridges were occupied by montane podocarp forest dominated by Phyllocladus and Halocarpus. Beech forest expanded into some sites as early as 13,000 yr BP but the modern beech cover was not established until the Holocene. Forest cover has fluctuated in response to disturbance over the Holocene, but the most significant recent change, which is related to clearing for pastoralism in the last two centuries, has had surprisingly little impact on the pollen records. (author). 40 refs., 11 figs., 1 tab
Notes on the influence of Carlos Nelson Coutinho on Social Work in Brazil

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Mabile Caetano Cazela

2017-06-01

Full Text Available The paper reports some results of a research study conducted for the master’s thesis in Social Work entitled Fundamental ethical principles of Social Work in Brazil: a study on the influence of Carlos Nelson Coutinho. It is based on bibliographic and field research, and it identifies and recognizes the influence of Coutinho on Social Work, as well as the intellectual contribution of Social Workers that are members of the Code of Ethics Revision Committee.
YBCO single crystals I-V characteristics nonlinearity and Nelson-Kosterlitz jump

International Nuclear Information System (INIS)

Kuzmichev, N.D.; Vasyutin, M.A.; Golovashkin, A.I.

2007-01-01

Temperature dependences of I-V characteristics and voltage harmonics V n (T) (n = 2, 3, ...) have been investigated in magnetic fields up to 200 Oe for single crystals YBa 2 Cu 3 O 7-x . It was shown that V n (T) had asymmetric peak form with maximum at T* = 92.0 K. Amplitudes of V n (T) were decreased in magnetic fields. The results were explained on the base of the Berezinskii-Kosterlitz-Thouless (BKT) transition model. It was shown that T* coincided with the BKT transition temperature T BKT . The asymmetric peaks of V n (T) are a consequence of the Nelson-Kosterlitz jump
Management of Cushing disease.

Science.gov (United States)

Tritos, Nicholas A; Biller, Beverly M K; Swearingen, Brooke

2011-05-01

Cushing disease is caused by a corticotroph tumor of the pituitary gland. Patients with Cushing disease are usually treated with transsphenoidal surgery, as this approach leads to remission in 70-90% of cases and is associated with low morbidity when performed by experienced pituitary gland surgeons. Nonetheless, among patients in postoperative remission, the risk of recurrence of Cushing disease could reach 20-25% at 10 years after surgery. Patients with persistent or recurrent Cushing disease might, therefore, benefit from a second pituitary operation (which leads to remission in 50-70% of cases), radiation therapy to the pituitary gland or bilateral adrenalectomy. Remission after radiation therapy occurs in ∼85% of patients with Cushing disease after a considerable latency period. Interim medical therapy is generally advisable after patients receive radiation therapy because of the long latency period. Bilateral adrenalectomy might be considered in patients who do not improve following transsphenoidal surgery, particularly patients who are very ill and require rapid control of hypercortisolism, or those wishing to avoid the risk of hypopituitarism associated with radiation therapy. Adrenalectomized patients require lifelong adrenal hormone replacement and are at risk of Nelson syndrome. The development of medical therapies with improved efficacy might influence the management of this challenging condition.
Caesarean section deliveries: Experiences of mothers of midwifery care at a public hospital in Nelson Mandela Bay

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Thobeka P. Jikijela

2018-01-01

Conclusion: Experiences of mothers following a caesarean section delivery with midwifery services at a public hospital in Nelson Mandela Bay were explored and described as diverse. A need for adequate pain management as well as assistance and breastfeeding support to mothers following caesarean delivery was identified as crucial to promote a good mother-to-child relationship.
Perceptions of patient-centred care at public hospitals in Nelson Mandela Bay

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Sihaam Jardien-Baboo

2016-10-01

Full Text Available In South Africa, the quality of health care is directly related to the concept of patient-centred care and the enactment of the Batho Pele Principles and the Patients' Rights Charter. Reports in the media indicate that public hospitals in the Eastern Cape Province are on the brink of collapse, with many patients being treated in condemned hospitals which lacked piped water, electricity and essential medical equipment. Receiving quality care, and principally patient-centred care, in the face of such challenges is unlikely and consequently leads to the following question: “Are patients receiving patient-centred care in public hospitals?” A qualitative, explorative, descriptive and contextual study was conducted to explore and describe the perceptions of professional nurses regarding patient-centred care in public hospitals in Nelson Mandela Bay. Semi-structured interviews were conducted with a total of 40 purposively selected professional nurses working in public hospitals in Nelson Mandela Bay, Eastern Cape Province. Interviews were analysed according to the method described by Tesch in Creswell (2009:192. Professional nurses perceive patient-centred care as an awareness of the importance of the patient's culture, involving the patient's family, incorporating values of love and respect, optimal communication in all facets of patient care and accountability to the patient. Factors which enable patient-centred care were a positive work environment for staff, nursing manager's demonstrating exemplary professional leadership, continuous in service education for staff and collaborative teamwork within the interdisciplinary team. Barriers to patient-centred care were a lack of adequate resources, increased administrative work due to fear of litigation and unprofessional behaviour of nursing staff.

Commentary: The Development of Hippocampal-Dependent Memory Functions: Theoretical Comments on Jabès and Nelson Review (2015)

Science.gov (United States)

Bachevalier, Jocelyne

2015-01-01

Studies investigating the development of memory processes and their neural substrates have flourished over the past two decades. The review by Jabès and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development…
The late Pleistocene glacial sequence in the middle Maruia valley, southeast Nelson, New Zealand

International Nuclear Information System (INIS)

Mabin, M.C.G.

1983-01-01

Glacial and fluvioglacial landforms and deposits preserved in the middle reaches of the Maruia valley, southeast Nelson, New Zealand, record the activity of the Maruia glacier during the late Pleistocene Otira Glaciation. Five advances are recognised, from oldest to youngest: Creighton 1, 2, 3, and the Reid Stream 1, 2 advances. There was an interstadial interval between the Creighton 3 and Reid Stream 1 advances. The Reid Stream 1 advance occurred shortly after 14 800 years B.P. (NZ536, old T/sub 0.5/). (auths)
Hot-plasma decoupling condition for long-wavelength modes

International Nuclear Information System (INIS)

Berk, H.L.; Van Dam, J.W.; Spong, D.

1982-10-01

The stability of layer modes is analyzed for z-pinch and bumpy cylinder models. These modes are long wavelength across the layer and flute-like along the field line. The stability condition can be expressed in terms of the ratio of hot to core plasma density. It is shown that to achieve conditions close to the Nelson, Lee-Van Dam core beta limit, one needs a considerably smaller hot to core plasma density than is required to achieve stability at zero core beta
Quantum cybernetics: a new perspective for Nelson's stochastic theory, nonlocality, and the Klein-Gordon equation

Science.gov (United States)

Grössing, Gerhard

2002-04-01

The Klein-Gordon equation is shown to be equivalent to coupled partial differential equations for a sub-quantum Brownian movement of a “particle”, which is both passively affected by, and actively affecting, a diffusion process of its generally nonlocal environment. This indicates circularly causal, or “cybernetic”, relationships between “particles” and their surroundings. Moreover, in the relativistic domain, the original stochastic theory of Nelson is shown to hold as a limiting case only, i.e., for a vanishing quantum potential.
The divine clockwork: Bohr's correspondence principle and Nelson's stochastic mechanics for the atomic elliptic state

International Nuclear Information System (INIS)

Durran, Richard; Neate, Andrew; Truman, Aubrey

2008-01-01

We consider the Bohr correspondence limit of the Schroedinger wave function for an atomic elliptic state. We analyze this limit in the context of Nelson's stochastic mechanics, exposing an underlying deterministic dynamical system in which trajectories converge to Keplerian motion on an ellipse. This solves the long standing problem of obtaining Kepler's laws of planetary motion in a quantum mechanical setting. In this quantum mechanical setting, local mild instabilities occur in the Keplerian orbit for eccentricities greater than (1/√(2)) which do not occur classically
Fathers of the Nation: Barack Obama Addresses Nelson Mandela

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Elisa Bordin

2014-11-01

Full Text Available This essay analyzes Barack Obama’s Nelson Mandela Memorial speech together with other seminal texts of Obama’s political and personal creed, such as his book Dreams from My Father (1995 and his speech “A More Perfect Union” (2008. This reading becomes helpful to understand Mandela’s transnational power, which Obama uses to comment on the United States by comparing Madiba to other American “fathers of the nation.” Thus, he uproots Mandela’s from a specifically South African legacy, expands his figure, and addresses him as a transnational father of his own nation, whose power, influence, and example transcend South African borders. As a consequence of this enlargement and transnational validation of Mandela’s figure, the speech delivered at the Memorial becomes an occasion to tackle American past and future, while the memory of Madiba and his driving example in Obama’s life serve to reinforce previous positions conveyed in other discourses by the American President, such as the “A More Perfect Union” speech delivered in Philadelphia in 2008.
Available data sources for monitoring non-communicable diseases ...

African Journals Online (AJOL)

The importance of quality data[1,2] in health service delivery, pro ... records on HIV and tuberculosis (TB), while not perfect, have ... 3 Discipline of Public Health Medicine, School of Nursing and Public Health, College of Health Sciences, Nelson R Mandela ... We differentiated risk conditions (hypertension, obesity and.
Caesarean section deliveries: Experiences of mothers of midwifery care at a public hospital in Nelson Mandela Bay.

Science.gov (United States)

Jikijela, Thobeka P; James, Sindiwe; Sonti, Balandeli S I

2018-01-30

The rate of caesarean section deliveries has increased globally and mothers are faced with challenges of postoperative recovery and caring thereof. Midwives have a duty to assist these mothers to self-care. The objective was to explore and describe experiences of post-caesarean section delivered mothers of midwifery care at a public hospital in Nelson Mandela Bay. A qualitative, descriptive and explorative research design was used in the study. Data were collected from 11 purposively criterion-selected mothers who had a caesarean section delivery. One-on-one semi-structured interviews were conducted in the post-natal wards. Research ethics, namely autonomy, beneficence, justice and informed consent, were adopted in the study. All participants were informed of their right to withdraw from the study at any stage without penalties. Interviews were analysed using Tesch's method of data analysis. Three main themes were identified as experiences of: diverse pain, physical limitation and frustration and health care services as different. Experiences of mothers following a caesarean section delivery with midwifery services at a public hospital in Nelson Mandela Bay were explored and described as diverse. A need for adequate pain management as well as assistance and breastfeeding support to mothers following caesarean delivery was identified as crucial to promote a good mother-to-child relationship.
Whole Exome Analysis of Early Onset Alzheimer’s Disease

Science.gov (United States)

2017-04-01

Alzheimer’s Disease 5a. CONTRACT NUMBER W81XWH-12-1-0013 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Margaret A. Pericak-Vance, Ph.D...Gerald D. Schellenberg, Goldie S . Byrd, Jonathan L. Haines, Margaret A. Pericak-Vance, and the Alzheimer Disease Genetics Consortium. ABCA7 Frameshift...Alzheimer’s & Parkinson’s Diseases (AD/PD), Vienna, Austria, Mar 29-Apr 2, 2017: Cukier HN, Gross SP, Kunkle BW, Rolati S , Hamilton-Nelson KL, Whitehead PL
Condition Assessment of a 2,500-Year-Old Mummy Coffin

Science.gov (United States)

Robert J. Ross; Turker Dundar

2012-01-01

This work was conducted to assess the condition of a 2,500-year-old mummy coffin. The coffin, part of a collection of funerary objects at the NelsonâAtkins Museum of Art in St. Louis, Missouri, is made of wood obtained from a sycamore fig tree, Ficus sycomorus. Visual and acoustic-based nondestructive testing techniques were used to inspect the...
Generalisability of the results of the Dutch-Belgian randomised controlled lung cancer CT screening trial (NELSON) : Does self-selection play a role?

NARCIS (Netherlands)

van der Aalst, C. M.; van Iersel, C. A.; van Klaveren, R. J.; Frenken, F. J. M.; Fracheboud, J.; Otto, S. J.; de Jong, P. A.; Oudkerk, M.; de Koning, H. J.

The degree of self-selection in the Dutch-Belgian randomised controlled lung cancer screening trial (NELSON) was determined to assess the generalisability of the study results. 335,441 (mainly) men born in 1928-1953 received a questionnaire. Of the respondents (32%), eligible subjects were invited
Does Deafness Spell Disaster? An Analysis of the Written English Levels of Deaf Children in the Nelson Mandela Metropole, South Africa

Science.gov (United States)

Weir, Carolyn; Aylif, Diana

2014-01-01

This article presents the findings of an empirical comparative study in the Nelson Mandela Metropole investigating the difference between the written English of deaf children and the written English of hearing children and makes recommendations on how to improve the writing of deaf children. The psycholinguistic approach was used for the…
Conditioning and learning in relation to disease.

Science.gov (United States)

Ban, T A; Guy, W

1985-12-01

Of the two generally recognized processes through which learning occurs--imprinting and conditioning--only the latter with its two paradigms, classical and operant, has both practical and heuristic implications for disease. From the classical conditioning experiments of Pavlov's laboratory over 100 years ago to the later work in operant conditioning by Skinner and others in the past four decades has evolved much of the basis of modern learning theory and its applications to disease in the form of behavior therapy. Variants of behavior therapy have been employed in the treatment of wide variety of medical and psychiatric illnesses. Recent developments in the study of brain function and biochemistry have led to renewed interest in the conditioning paradigm and its value as tool in these areas of research.
Disease: H00557 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available Grix A, Sommer A, Savarirayan R, Janecke AR, Steichen E, Sillence D, Hausser I, Budde B, Nurnberg G, Nurnber...iman B, Nelson SF, Masri A, Alkazaleh F, Guerra D, Ferrari P, Nanda A, Rajab A, Markie D, Gray M, Nelson J,
Conservative diffusions: a constructive approach to Nelson's stochastic mechanics

International Nuclear Information System (INIS)

Carlen, E.A.

1984-01-01

In Nelson's stochastic mechanics, quantum phenomena are described in terms of diffusions instead of wave functions; this thesis is a study of that description. Concern here is with the possibility of describing, as opposed to explaining, quantum phenomena in terms of diffusions. In this direction, the following questions arise: ''Do the diffusion of stochastic mechanics - which are formally given by stochastic differential equations with extremely singular coefficients - really exist.'' Given that they exist, one can ask, ''Do these diffusions have physically reasonable paths to study the behavior of physical systems.'' These are the questions treated in this thesis. In Chapter 1, stochastic mechanics and diffusion theory are reviewed, using the Guerra-Morato variational principle to establish the connection with the Schroedinger equation. Chapter II settles the first of the questions raised above. Using PDE methods, the diffusions of stochastic mechanics are constructed. The result is sufficiently general to be of independent mathematical interest. In Chapter III, potential scattering in stochastic mechanics is treated and direct probabilistic methods of studying quantum scattering problems are discussed. The results provide a solid YES in answer to the second question raised above
Fome, eugenia e constituição do campo da nutrição em Pernambuco: uma análise de Gilberto Freyre, Josué de Castro e Nelson Chaves Starvation, eugenics and the development of nutrition in Pernambuco according to Gilberto Freire's, Josué de Castro's and Nelson Chaves' analyses

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Francisco de Assis Guedes de Vasconcelos

2001-08-01

Full Text Available O objetivo deste artigo é examinar a contribuição dos estudos de Gilberto Freyre, Josué de Castro e Nelson Chaves, produzidos nas décadas de 1930 e 1940, para o processo de constituição do campo da nutrição em Pernambuco. O estudo procura demonstrar que as temáticas fome e eugenia constituem as categorias centrais que expressam os pontos de tensão e de comunhão das abordagens desses autores pernambucanos, pelo estatuto científico nesse campo do conhecimento.The purpose of this article is to examine the contribution of the studies Gilberto Freyre, Josué de Castro and Nelson Chaves produced for the development of the Pernambuco nutrition field, from 1930 to 1940. The article attempts to demonstrate that both subjects - starvation and eugenics - are the central categories that express tension and communion in these three authors' approaches to this field of knowledge.
Death of Nelson Mandela: CERN and its Staff Association in history

CERN Multimedia

Staff Association

2013-01-01

Shortly after the conviction of Nelson Mandela at the Rivonia trial in 1964, the Anti-Apartheid Movement of Geneva was created at a meeting at CERN. Arriving at CERN as Visiting Scientist in June 1966, I joined the Anti-Apartheid Movement immediately. We multiplied the initiatives at CERN and outside of CERN until the release of Mandela with citizens of Geneva, but also with "citizens of the world", who ignored the ban on political activity, particularly for international civil servants. The Anti-Apartheid Movement of Geneva soon became the Anti-Apartheid Movement of Switzerland. It was also the first Anti-Apartheid Movement outside of South Africa. CERN today is honoured to have brought it to the baptismal font thanks to the initiative of several colleagues, including Mike Pentz, president of the CERN staff Association for two years (1961  1963) and also a refugee from South Africa in Europe. Conclusion: well-targeted disobedience can advance humanity. Jean-Pierre Lagnaux, former vis...
Addison's disease and ACTH-producing pituitary microadenoma

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S.S. Ortega

2015-10-01

Full Text Available A 28-year-old man diagnosed with primary adrenal insufficiency (Addison's disease in 2002. Following diagnosis, replacement therapy with hydrocortisone and fludrocortisone was indicated. Hydrocortisone replacement therapy was unsuccessful, and increased ACTH levels as high as 996 pg/dl were observed on outpatient follow-up. A pituitary MRI revealed a pituitary microadenoma. These findings raised three possibilities: (1 treatment is insufficient; (2 there is no relationship between Addison's disease and pituitary microadenoma; and (3 the microadenoma is similar to Nelson's syndrome. This latter is the most satisfactory explanation of this patient's clinical picture.
Análise crítica da metáfora no discurso inaugural de Nelson Mandela

OpenAIRE

Candia, Guilene Detimermane de Souza

2009-01-01

Esta dissertação de mestrado refere-se à pesquisa, sob a perspectiva crítica e pragmática, das metáforas conceptuais e lingüísticas que tenham o sentido de portadora de ideologia e de estratégia de polidez num discurso político. Teve como base de estudo o Discurso Inaugural do líder sul-africano, Nelson Rolihlahla Mandela, proferido na ocasião de sua posse como presidente da África do Sul, em 10 de maio de 1994, na cidade de Johannesburgo, capital daquele país. O discurso fo...
"A eloqüência farfalhante da tribuna do júri": o tribunal popular e a lei em Nelson Hungria "A eloqüência farfalhante da tribuna do júri": the people's court and the law in Nelson Hungria

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Ricardo Sontag

2009-01-01

Full Text Available Este artigo pretende analisar a questão do júri no pensamento do penalista Nelson Hungria levando em consideração o contexto histórico das transformações sofridas pelas instituições penais durante o Estado Novo (particularmente as leis sobre o júri e os códigos penal e de processo penal de 1940 e 1941 respectivamente, até o post scriptum do percurso com as modificações trazidas pela Constituição de 1946 e pela lei 268 de 1947 e os seus escritos mais tardios. O aspecto chave a ser considerado nesse percurso é a (indistinção no uso por parte de Hungria dos argumentos do tecnicismo jurídico-penal em relação àqueles do positivismo criminológico dependendo do contexto histórico.This article aims to explore the issue of the jury in Nelson Hungria's thought considering the historical context of the transformations suffered by the criminal law institutions during the "Estado Novo" (particularly the laws on the jury and the criminal code - 1940 - and criminal procedure code - 1941 to the post scriptum of the process with the changes brought by the Constitution of 1946 and the law 268 of 1947 and his later writings. The key aspect to be considered in this process is the (indistinction used by Hungria of the arguments of the criminal-legal technicism in relation to those of criminological positivism depending on historical context.

Provision of antiretroviral therapy for children in Nelson Mandela Bay: Health care professionals’ challenges

Science.gov (United States)

2018-01-01

Background The human immunodeficiency virus and/or acquired immune deficiency syndrome (HIV/AIDS) pandemic continues to increase in prevalence worldwide, particularly in South Africa, and includes the often overlooked paediatric population. The provision of paediatric antiretroviral treatment (ART) is as essential for children as for adults, and has numerous obstacles, not least of which is lack of decentralisation of facilities to provide essential treatment. Optimising ART, care and support for HIV-positive children, and their caregivers, at public sector primary health care (PHC) clinics is crucial to improve morbidity and mortality rates in children. Aim To explore the experiences of health care professionals regarding the provision of ART for children at PHC clinics. Setting The study was conducted in six PHC clinics in Nelson Mandela Bay Health District, Eastern Cape, South Africa. Methodology The researchers used a qualitative, explorative, descriptive and contextual research design with in-depth interviews. We used non-probability purposive sampling. Data collected were thematically analysed using Creswell’s data analysis spiral. We used Lincoln and Guba’s model to ensure trustworthiness. Ethical standards were applied. Results Health care professionals experienced numerous challenges, such as lack of resources, need for training, mentoring and debriefing, all related to providing decentralised ART for HIV-positive children at the PHC level. Conclusion Capacitation of the health care system, integration of services, competent management and visionary leadership to invoke a collaborative interdisciplinary team approach is required to ensure that HIV is treated as a chronic disease at the PHC clinic level. PMID:29781680
Provision of antiretroviral therapy for children in Nelson Mandela Bay: Health care professionals' challenges.

Science.gov (United States)

Williams, Margaret; Van Rooyen, Dalena R M; Ricks, Esmeralda J

2018-03-12

The human immunodeficiency virus and/or acquired immune deficiency syndrome (HIV/AIDS) pandemic continues to increase in prevalence worldwide, particularly in South Africa, and includes the often overlooked paediatric population. The provision of paediatric antiretroviral treatment (ART) is as essential for children as for adults, and has numerous obstacles, not least of which is lack of decentralisation of facilities to provide essential treatment. Optimising ART, care and support for HIV-positive children, and their caregivers, at public sector primary health care (PHC) clinics is crucial to improve morbidity and mortality rates in children. To explore the experiences of health care professionals regarding the provision of ART for children at PHC clinics. The study was conducted in six PHC clinics in Nelson Mandela Bay Health District, Eastern Cape, South Africa. The researchers used a qualitative, explorative, descriptive and contextual research design with in-depth interviews. We used non-probability purposive sampling. Data collected were thematically analysed using Creswell's data analysis spiral. We used Lincoln and Guba's model to ensure trustworthiness. Ethical standards were applied. Health care professionals experienced numerous challenges, such as lack of resources, need for training, mentoring and debriefing, all related to providing decentralised ART for HIV-positive children at the PHC level. Capacitation of the health care system, integration of services, competent management and visionary leadership to invoke a collaborative interdisciplinary team approach is required to ensure that HIV is treated as a chronic disease at the PHC clinic level.
Intracranial suppuration: Review of an 8-year experience at Umtata General Hospital and Nelson Mandela Academic Hospital, Eastern Cape, South Africa.

Science.gov (United States)

Anwary, M A

2015-09-21

Intracranial suppuration (ICS) is a life-threatening condition caused by various disease processes and consisting of brain abscess and extradural and subdural empyema. The major causes have changed over the decades. To the author's knowledge, the incidence of ICS in South Africa (SA) has not been established. To determine the incidence of ICS, overall and according to age and gender, and to identify the source and distribution of ICS. The archive of the radiology departments at Umtata General Hospital and Nelson Mandela Academic Hospital in the Transkei region, Eastern Cape Province, SA, was searched retrospectively for computed tomography (CT) reports of patients diagnosed with ICS. Cases in which the CT images, patients' clinical information and CT reports were available for an uninterrupted period of at least 1 year were included. Five time frames were established, encompassing 8 years of data. The first time frame established an incidence of ICS of 1/100,000/year for the Transkei region. All the time frames were utilised to determine the incidence according to gender and age, and the source and distribution of ICS. The incidence of ICS was higher among males than females, and highest in the age groups 0-10 and 11-20 years. A seasonal variation in the incidence of sinusitis- and meningitis-related ICS was noted. Numbers of cases declined during the last 3 years of the study period. Sinusitis, head trauma, ear infection and meningitis were the major sources of ICS. A pulmonary source was not a major feature. In the last 4 years, trauma became the commonest source of ICS. A steady decline in ear infection- and meningitis-related ICS was noted.
Nelson Mandela’s ‘Ordinary Love’ Addressed in Pop-rock Music: a Long Song of Freedom

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Simona Martini

2014-11-01

Full Text Available This paper aims to highlight how inspirational the figure of Nelson Mandela has been for several musicians and songwriters. In particular, it focuses on songs written by Western musicians from the early Eighties until 2013 – all showing the extent to which the South African leader has epitomized the struggle for equality and freedom. This study points out how the success of a hit single in 1984 – British ska group The Special AKA’s “Free Nelson Mandela” – paved the way for a quick increase in the number of musicians who got involved in the anti-apartheid movement and contributed to make Western audiences know about Mandela and increasingly demand that apartheid be put to an end. This survey seeks to examine the main achievements in pop-rock songs that generated both from the growing awareness about the South African leader’s experience when he was imprisoned, and the legacy of his exemplum after he was set free. Among the songs cited: Simple Minds’ “Mandela Day”, the various artists’ tribute “46664” and the most recent Golden Globe-awarded “Ordinary Love” by U2, written for the soundtrack of the biopic The Long Walk to Freedom. To better understand how the figure of Mandela has been addressed in these works, the paper includes analyses of the most complex and significant lyrics among the songs discussed, thus also showing how the South African cultural background as it was received by the West could have informed the songwriting, and how the Western reception of such songs determined an increasing awareness about Mandela’s plight and the whole phenomenon of apartheid.
The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L. A. Nelson

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Beata Olas

2018-03-01

Full Text Available Various parts of sea buckthorn [Elaeagnus rhamnoides (L. A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C, unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a “golden mean” for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and animal in vivo studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.
Incentives for HIV testing at the workplace in the automotive industry in the Nelson Mandela Bay Municipality: Ethical considerations

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Martin Weihs

2017-07-01

Full Text Available Comprehensive HIV and AIDS workplace programmes made use of substantial lottery incentives in HIV counselling and testing drives to promote HIV testing at four companies in the automotive industry in the Nelson Mandela Bay Municipality. The main aim was to use lottery incentives to increase uptake for HIV testing. This would help to define company HIV prevalence and ensure timely support, care and treatment of employees. In total, 1 324 employees, making up about 90% of the total staff, were tested for HIV in the four companies during wellness testing days. In order to gain an understanding of employeesâ€™ experiences of the lotteries as part of the HIV counselling and testing drive, quantitative data were collected among a total of 414 employees, and 17 interviews were conducted in the four companies. In this article, we investigate the issue of whether the lotteries unduly influenced the employeesâ€™ participation in workplace HIV testing, and an approach to resolving an identified ethical dilemma is presented. The ethical question as to whether lottery incentives contribute to undue coercion was explored using both a utilitarian and a deontological approach. The analysis concluded that the use of lotteries to encourage HIV testing in the workplaces of the automotive industry in the Nelson Mandela Bay Municipality can be deemed morally acceptable.
Incentives for HIV testing at the workplace in the automotive industry in the Nelson Mandela Bay Municipality: Ethical considerations

Directory of Open Access Journals (Sweden)

Martin Weihs

2017-07-01

Full Text Available Comprehensive HIV and AIDS workplace programmes made use of substantial lottery incentives in HIV counselling and testing drives to promote HIV testing at four companies in the automotive industry in the Nelson Mandela Bay Municipality. The main aim was to use lottery incentives to increase uptake for HIV testing. This would help to define company HIV prevalence and ensure timely support, care and treatment of employees. In total, 1 324 employees, making up about 90% of the total staff, were tested for HIV in the four companies during wellness testing days. In order to gain an understanding of employees’ experiences of the lotteries as part of the HIV counselling and testing drive, quantitative data were collected among a total of 414 employees, and 17 interviews were conducted in the four companies. In this article, we investigate the issue of whether the lotteries unduly influenced the employees’ participation in workplace HIV testing, and an approach to resolving an identified ethical dilemma is presented. The ethical question as to whether lottery incentives contribute to undue coercion was explored using both a utilitarian and a deontological approach. The analysis concluded that the use of lotteries to encourage HIV testing in the workplaces of the automotive industry in the Nelson Mandela Bay Municipality can be deemed morally acceptable.
Coulomb Scattering in the Massless Nelson Model III: Ground State Wave Functions and Non-commutative Recurrence Relations

Science.gov (United States)

Dybalski, Wojciech; Pizzo, Alessandro

2018-02-01

Let $H_{P,\\sigma}$ be the single-electron fiber Hamiltonians of the massless Nelson model at total momentum $P$ and infrared cut-off $\\sigma>0$. We establish detailed regularity properties of the corresponding $n$-particle ground state wave functions $f^n_{P,\\sigma}$ as functions of $P$ and $\\sigma$. In particular, we show that \\[ |\\partial_{P^j}f^{n}_{P,\\sigma}(k_1,\\ldots, k_n)|, \\ \\ |\\partial_{P^j} \\partial_{P^{j'}} f^{n}_{P,\\sigma}(k_1,\\ldots, k_n)| \\leq \\frac{1}{\\sqrt{n!}} \\frac{(c\\lambda_0)^n}{\\sigma^{\\delta_{\\lambda_0}}} \\prod_{i=1}^n\\frac{ \\chi_{[\\sigma,\\kappa)}(k_i)}{|k_i|^{3/2}}, \\] where $c$ is a numerical constant, $\\lambda_0\\mapsto \\delta_{\\lambda_0}$ is a positive function of the maximal admissible coupling constant which satisfies $\\lim_{\\lambda_0\\to 0}\\delta_{\\lambda_0}=0$ and $\\chi_{[\\sigma,\\kappa)}$ is the (approximate) characteristic function of the energy region between the infrared cut-off $\\sigma$ and the ultraviolet cut-off $\\kappa$. While the analysis of the first derivative is relatively straightforward, the second derivative requires a new strategy. By solving a non-commutative recurrence relation we derive a novel formula for $f^n_{P,\\sigma}$ with improved infrared properties. In this representation $\\partial_{P^{j'}}\\partial_{P^{j}}f^n_{P,\\sigma}$ is amenable to sharp estimates obtained by iterative analytic perturbation theory in part II of this series of papers. The bounds stated above are instrumental for scattering theory of two electrons in the Nelson model, as explained in part I of this series.
Global Climate Model Simulated Hydrologic Droughts and Floods in the Nelson-Churchill Watershed

Science.gov (United States)

Vieira, M. J. F.; Stadnyk, T. A.; Koenig, K. A.

2014-12-01

There is uncertainty surrounding the duration, magnitude and frequency of historical hydroclimatic extremes such as hydrologic droughts and floods prior to the observed record. In regions where paleoclimatic studies are less reliable, Global Climate Models (GCMs) can provide useful information about past hydroclimatic conditions. This study evaluates the use of Coupled Model Intercomparison Project 5 (CMIP5) GCMs to enhance the understanding of historical droughts and floods across the Canadian Prairie region in the Nelson-Churchill Watershed (NCW). The NCW is approximately 1.4 million km2 in size and drains into Hudson Bay in Northern Manitoba, Canada. One hundred years of observed hydrologic records show extended dry and wet periods in this region; however paleoclimatic studies suggest that longer, more severe droughts have occurred in the past. In Manitoba, where hydropower is the primary source of electricity, droughts are of particular interest as they are important for future resource planning. Twenty-three GCMs with daily runoff are evaluated using 16 metrics for skill in reproducing historic annual runoff patterns. A common 56-year historic period of 1950-2005 is used for this evaluation to capture wet and dry periods. GCM runoff is then routed at a grid resolution of 0.25° using the WATFLOOD hydrological model storage-routing algorithm to develop streamflow scenarios. Reservoir operation is naturalized and a consistent temperature scenario is used to determine ice-on and ice-off conditions. These streamflow simulations are compared with the historic record to remove bias using quantile mapping of empirical distribution functions. GCM runoff data from pre-industrial and future projection experiments are also bias corrected to obtain extended streamflow simulations. GCM streamflow simulations of more than 650 years include a stationary (pre-industrial) period and future periods forced by radiative forcing scenarios. Quantile mapping adjusts for magnitude
The proposed Nelson Mandela Children's Hospital, Johannesburg: providing the best care for children in the developing world.

Science.gov (United States)

Bolton, Keith

2011-01-01

Construction will soon commence on the Nelson Mandela Children's Hospital (NMCH) in Johannesburg, South Africa. The Hospital will have 250-300 beds and will provide tertiary and quaternary care to children in specific Centers of Excellence. Admission to this referral facility will be based entirely on medical needs. The disciplines that are catered for include Paediatric surgery, oncology, nephrology, cardiology, intensive care and imaging. The NMCH will be South Africa's first "Private Hospital - Not for Gain". Funding for capital expenditure is currently being raised by the Trust. Operational expenditure will come from the Department of Health, private insurers and neighbouring governments.
Diagnosis application of ACTH radioimmunoassay in diseases of hypothalamus, hypophysis and adrenal axis

International Nuclear Information System (INIS)

Moreira, A.C.; Foss, M.C.; Iazigi, N.

1988-01-01

The diagnostic value of 900-1,100 am plasma ACTH radioimmunoassay were studied in 10 patients with Cushing's disease before and after treatment, three patients with Cushing's syndrome with adrenal tumours, one Nelson's syndrome patient; 13 patients with Addison's disease and 12 patients with hypo-pituitarism. Twenty-seven normal subjects were controls. The measurement of basal plasma ACTH gave good differentiation between: a. pituitary Cushing's disease from adrenal tumors; b. Addison's disease from hypo-pituitarism. However this assay has a limited value for the differentiation between Cushing's disease from normal subjects and it is often unhelpful in the differential diagnosis of hypo-pituitarism from normal subjects. (author)
The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.

CERN Multimedia

Maximilien Brice

2008-01-01

The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.
The effects of extinction-aroused attention on context conditioning.

Science.gov (United States)

Nelson, James Byron; Fabiano, Andrew M; Lamoureux, Jeffrey A

2018-04-01

Two experiments assessed the effects of extinguishing a conditioned cue on subsequent context conditioning. Each experiment used a different video-game method where sensors predicted attacking spaceships and participants responded to the sensor in a way that prepared them for the upcoming attack. In Experiment 1 extinction of a cue which signaled a spaceship-attack outcome facilitated subsequent learning when the attack occurred unsignaled. In Experiment 2 extinction of a cue facilitated subsequent learning, regardless of whether the spaceship outcome was the same or different as used in the earlier training. In neither experiment did the extinction context become inhibitory. Results are discussed in terms of current associative theories of attention and conditioning. © 2018 Nelson et al.; Published by Cold Spring Harbor Laboratory Press.
Forest insect & disease conditions in the Northeast - 1956

Science.gov (United States)

W. E. Waters; Alma M. Waterman

1957-01-01

This annual report on forest pest conditions in the Northeast combines, for the first time, information about both the major forest insects and the major forest diseases in the region. It was prepared as an aid to those who have a concern for protecting our forests from insect and disease attacks.
Morgellons Disease: Managing a Mysterious Skin Condition

Science.gov (United States)

... condition that affects your thinking, moods or behavior. Pearson ML, et al. Clinical epidemiologic, histopathologic and molecular ... Dermatology. 2014;15:71. Yan BY, et al. Management of Morgellons disease with low-dose trifluoperazine. JAMA ...
Radiocarbon dates from the holocene levels at Nelson Bay Cave, and an interim report on their associations

International Nuclear Information System (INIS)

Inskeep, R.R.; Vogel, J.C.

1985-01-01

Various changes in the cultural material derived from the later Holocene levels of Nelson Bay Cave can be pinpointed in temporal context by means of a large series of radiocarbon dates, such as Carbon 13 and Carbon 14 covering the past 6 000 years. As excavations and analysis of the recovered materials proceeded, radiocarbon dates were sought in order to provide a chronological frame work for what are taken to be significant features in the history of the site, and these are discussed in the article. Several pottery and assumed sheep remains were recorded. Six human burials were also recovered and this helps with the characterization of Holocene burial practices
Late Otiran sedimentation and glacial chronology in the Warwick valley, southeast Nelson

International Nuclear Information System (INIS)

Mabin, M.C.G.

1983-01-01

Approximately 14 m of sediment are exposed in a road cutting beneath a landslide deposit in the Warwick valley, southeast Nelson, New Zealand. Three radiocarbon dates and 5 pollen spectra were obtained from organic horizons in these sediments. The dates indicate that lacustrine sedimentation predominated from before 17 500 until 14 450 years ago. This was interrupted by a brief period of gravel aggradation between 17 500 and 16 650 years ago, which is attributed to a glacial advance. Vegetation at the site was consistently dominated by Cyperaceae, with some Gramineae, suggesting a bleak, treeless landscape. Correlation of this information with other radiocarbon dated sites indicates the need for some revision of the chronology of the late Otira Glaciation. A late phase of the Kumara 2 2 advance occurred between 17 000 and 16 000 years ago, and the Kumara 3 1 advance did not occur until after about 15 000 years ago. The end of the Otira Glaciation probably occurred between 13 000 and 12 500 years ago. (auth)
Late Otiran sedimentation and glacial chronology in the Warwick valley, southeast Nelson

Energy Technology Data Exchange (ETDEWEB)

Mabin, M C.G. [Canterbury Univ., Christchurch (New Zealand). Dept. of Geology

1983-01-01

Approximately 14 m of sediment are exposed in a road cutting beneath a landslide deposit in the Warwick valley, southeast Nelson, New Zealand. Three radiocarbon dates and 5 pollen spectra were obtained from organic horizons in these sediments. The dates indicate that lacustrine sedimentation predominated from before 17,500 until 14,450 years ago. This was interrupted by a brief period of gravel aggradation between 17,500 and 16,650 years ago, which is attributed to a glacial advance. Vegetation at the site was consistently dominated by Cyperaceae, with some Gramineae, suggesting a bleak, treeless landscape. Correlation of this information with other radiocarbon dated sites indicates the need for some revision of the chronology of the late Otira Glaciation. A late phase of the Kumara 2/sub 2/ advance occurred between 17,000 and 16,000 years ago, and the Kumara 3/sub 1/ advance did not occur until after about 15,000 years ago. The end of the Otira Glaciation probably occurred between 13,000 and 12,500 years ago.
p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

Science.gov (United States)

Ulrich, Rolf; Miller, Jeff

2015-12-01

Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present. (c) 2015 APA, all rights reserved).
A Comparison of Conditional Volatility Estimators for the ISE National 100 Index Returns

OpenAIRE

Köksal, Bülent

2009-01-01

We compare more than 1000 different volatility models in terms of their fit to the historical ISE-100 Index data and their forecasting performance of the conditional variance in an out-of-sample setting. Exponential GARCH model of Nelson (1991) with “constant mean, t-distribution, one lag moving average term” specification achieves the best overall performance for modeling the ISE-100 return volatility. The t-distribution seems to characterize the distribution of the heavy tailed returns bett...

Classical eyeblink conditioning in Parkinson's disease.

Science.gov (United States)

Daum, I; Schugens, M M; Breitenstein, C; Topka, H; Spieker, S

1996-11-01

Patients with Parkinson's disease (PD) show impairments of a range of motor learning tasks, including tracking or serial reaction time task learning. Our study investigated whether such deficits would also be seen on a simple type of motor learning, classic conditioning of the eyeblink response. Medicated and unmediated patients with PD showed intact unconditioned eyeblink responses and significant learning across acquisition; the learning rates did not differ from those of healthy control subjects. The overall frequency of conditioned responses was significantly higher in the medicated patients with PD relative to control subjects, and there was also some evidence of facilitation in the unmedicated patients with PD. Conditioning of electrodermal and electrocortical responses was comparable in all groups. The findings are discussed in terms of enhanced excitability of brainstem pathways in PD and of the involvement of different neuronal circuits in different types of motor learning.
Economic losses and burden of disease by medical conditions in Norway.

Science.gov (United States)

Kinge, Jonas Minet; Sælensminde, Kjartan; Dieleman, Joseph; Vollset, Stein Emil; Norheim, Ole Frithjof

2017-06-01

We explore the correlation between disease specific estimates of economic losses and the burden of disease. This is based on data for Norway in 2013 from the Global Burden of Disease (GBD) project and the Norwegian Directorate of Health. The diagnostic categories were equivalent to the ICD-10 chapters. Mental disorders topped the list of the costliest conditions in Norway in 2013, and musculoskeletal disorders caused the highest production loss, while neoplasms caused the greatest burden in terms of DALYs. There was a positive and significant association between economic losses and burden of disease. Neoplasms, circulatory diseases, mental and musculoskeletal disorders all contributed to large health care expenditures. Non-fatal conditions with a high prevalence in working populations, like musculoskeletal and mental disorders, caused the largest production loss, while fatal conditions such as neoplasms and circulatory disease did not, since they occur mostly at old age. The magnitude of the production loss varied with the estimation method. The estimations presented in this study did not include reductions in future consumption, by net-recipients, due to premature deaths. Non-fatal diseases are thus even more burdensome, relative to fatal diseases, than the production loss in this study suggests. Hence, ignoring production losses may underestimate the economic losses from chronic diseases in countries with an epidemiological profile similar to Norway. Copyright © 2017 Elsevier B.V. All rights reserved.
Public acceptance of drug use for non-disease conditions

DEFF Research Database (Denmark)

Møldrup, Claus; Hansen, Rikke Rie

2006-01-01

OBJECTIVE: This article deals with the issue of ordinary healthy people using drugs to improve or enhance non-disease conditions. The objective is to illuminate the extent of public acceptance of this practice. RESEARCH DESIGN AND METHODS: The results are based on two studies: a classically...... of drugs for non-disease conditions. Men in particular look favourably on the use of drugs by healthy individuals. People with less education find this type of drug use unacceptable to a greater extent than those with more education, who are more positive. If we look at political affiliation, a pattern...
O MASOQUISMO MORAL NO “TEATRO DESAGRADÁVEL” DE NELSON RODRIGUES: APORTES PSICANALÍTICOS

Directory of Open Access Journals (Sweden)

Meury Gardênia Lima de Araújo

2015-06-01

Full Text Available Pretende-se desenvolver neste trabalho a psicanálise em extensão, com um delineamento investigativo sobre as obras teatrais míticas Anjo Negro e Dorotéia de Nelson Rodrigues, recorrendo-se ao que formula Freud sobre o conceito de masoquismo moral. Almeja-se, através de estudo bibliográfico, buscar e fazer interagir psicanálise e literatura, notando a coexistência na arte dos “mistérios” inconscientes do sujeito dividido, fictício em questão, “traduzidos” da vida real, primando pela criatividade e como ela expressa tão naturalmente o produto inconsciente. Expõe-se, por fim, as abordagens literárias pelo viés psicanalítico para apresentar suas contribuições ao legado freudiano, exibindo trechos das peças “Anjo Negro” e “Dorotéia” a fim de norteá-las estruturalmente.
Retrospective Analysis Of Disease Conditions Among Reproductive ...

African Journals Online (AJOL)

A fteen-year (1991 – 2005) study of reproductve cases in animals presented to the Usmanu Danfodio University Veterinary Teaching Hospital, Sokoto, were analyzed based on species, disease condition and sex using clinical case files of Sheep, goat and cattle. Within the study period a total of 88 reproductive cases were ...
True Grit: In Tracking down the Real Story of a Legendary Hero of the Old West, Vaunda Micheaux Nelson also Nabbed the Coretta Scott King Award

Science.gov (United States)

Fleishhacker, Joy

2010-01-01

When Vaunda Micheaux Nelson donned a black Stetson to become the biographer of Deputy U.S. Marshal Bass Reeves, she had no idea that her square-shooting book about an unsung African-American hero of the Old West would win over a posse of fans and earn her the prestigious 2010 Coretta Scott King (CSK) Author Award. "Bad News for Outlaws"…
Custeio dos gastos no serviço público de saúde: estudo de caso no Hospital Nelson Salles

OpenAIRE

Warley Francisco de Araújo Pereira

2014-01-01

A dissertação tem como objetivo aplicar um método de custeio aos gastos atribuídos, pelo Hospital Nelson Salles, na execução do serviço público de saúde, em apoio ao Município Engenheiro Paulo de Frontin. Para a realização deste trabalho, o estudo utilizou-se da pesquisa bibliográfica para fundamentar e ilustrar o tema proposto, bem como, do método exploratório descritivo para reconhecer a situação da instituição e identificar uma metodologia de controle dos custos adequada à realidade da org...
A poética da esperança: sentidos políticos nas memórias de Nelson Mandela

OpenAIRE

Silva, Cristiane Mare da

2016-01-01

O estudo que ora apresento desenvolveu-se no Programa de Pós-Graduação em História, da Pontifícia Universidade Católica de São Paulo e tem por objeto textos biográficos e autobiográficos do sul africano Nelson Mandela, que nos permitem apreender momentos e enunciados, orientadores da luta pela igualdade, do exercício da tolerância e a defesa dos direitos humanos, não apenas na África do Sul, mas por toda parte onde existam conflitos raciais e coloniais inerentes à enxpansão do Hemisfério Ocid...
Forest insect and disease conditions, Vancouver forest region, 1987. Annual publication

Energy Technology Data Exchange (ETDEWEB)

Humphreys, N; Ferris, R L

1988-01-01

The Forest Insect and Disease Survey (FIDS) is a nation-wide network within Forestry Canada with the responsibility of producing an overview of forest pest conditions and their implications; maintaining records and surveys to support quarantine and facilitate predictions; supporting forestry research with records, insect collections and herbaria; providing advice on forest insect and disease conditions; developing and testing survey techniques; and conducting related biological studies. This report outlines the status of forest pest conditions in the Vancouver Forest Region, and forecasts population trends of some potentially damaging pests. Pests are listed by host in order of importance.
Summary of Notifiable Infectious Diseases and Conditions - United States, 2015.

Science.gov (United States)

Adams, Deborah A; Thomas, Kimberly R; Jajosky, Ruth Ann; Foster, Loretta; Baroi, Gitangali; Sharp, Pearl; Onweh, Diana H; Schley, Alan W; Anderson, Willie J

2017-08-11

The Summary of Notifiable Infectious Diseases and Conditions - United States, 2015 (hereafter referred to as the summary) contains the official statistics, in tabular and graphical form, for the reported occurrence of nationally notifiable infectious diseases and conditions in the United States for 2015. Unless otherwise noted, data are final totals for 2015 reported as of June 30, 2016. These statistics are collected and compiled from reports sent by U.S. state and territories, New York City, and District of Columbia health departments to the National Notifiable Diseases Surveillance System (NNDSS), which is operated by CDC in collaboration with the Council of State and Territorial Epidemiologists (CSTE). This summary is available at https://www.cdc.gov/MMWR/MMWR_nd/index.html. This site also includes summary publications from previous years.
Summary of Notifiable Infectious Diseases and Conditions - United States, 2013.

Science.gov (United States)

Adams, Deborah; Fullerton, Kathleen; Jajosky, Ruth; Sharp, Pearl; Onweh, Diana; Schley, Alan; Anderson, Willie; Faulkner, Amanda; Kugeler, Kiersten

2015-10-23

The Summary of Notifiable Infectious Diseases and Condition-United States, 2013 (hereafter referred to as the summary) contains the official statistics, in tabular and graphic form, for the reported occurrence of nationally notifiable infectious diseases and conditions in the United States for 2013. Unless otherwise noted, data are final totals for 2013 reported as of June 30, 2014. These statistics are collected and compiled from reports sent by U.S. state and territory, New York City, and District of Columbia health departments to the National Notifiable Diseases Surveillance System (NNDSS), which is operated by CDC in collaboration with the Council of State and Territorial Epidemiologists (CSTE). This summary is available at http://www.cdc.gov/mmwr/mmwr_nd/index.html. This site also includes summary publications from previous years.
Approaches to daily body condition management in patients with stable chronic obstructive pulmonary disease.

Science.gov (United States)

Kawada, Terue

2016-11-01

To clarify the characteristics of sub-groups of patients with stable chronic obstructive pulmonary disease having similar approaches to daily body condition management. Prior literature has shed light on the experience of patients with chronic obstructive pulmonary disease and revealed that these patients engage in many activities and try different things in their daily lives to regulate and manage their body condition. The research so far has all been qualitative, comprising mostly interviews, and no quantitative studies have been performed. In this study, cluster analysis was used to show that subgroups of patients with similar characteristics undertake similar approaches to body condition management. Descriptive, correlational study. Invitations to participate in the survey were extended to patients with stable chronic obstructive pulmonary disease. Cluster analysis was performed on the basis of questionnaire scores relating to nine different categories of daily body condition management actions. The characteristics of the body condition management approaches, in each subgroup, were investigated using analysis of variance and multiple comparisons. The cluster analysis produced six subgroups, each defined by the effort expended as part of their body condition management. The subgroups also differed depending on patient age and disease severity. Body condition management approaches taken by patients with stable chronic obstructive pulmonary disease are overall, comprehensive approaches. Patients with chronic obstructive pulmonary disease were subgrouped based on their engagement in body conditioning. Relationships between the subgroups and the engagement in body conditioning, age and shortness of breath severity were observed. The care of patient support should be comprehensive and depend on their age and the duration of the disease. In addition, it should be long term and recognise that the patients are living their own respective lives. Such considerations and
Celiac Disease and Concomitant Conditions: A Case-based Review.

Science.gov (United States)

Lodhi, Muhammad Uzair; Stammann, Tracy; Kuzel, Aaron R; Syed, Intekhab Askari; Ishtiaq, Rizwan; Rahim, Mustafa

2018-02-02

Celiac disease is a chronic autoimmune disease with genetic predisposition, triggered by the ingestion of gluten. It has a wide range of clinical manifestations ranging from asymptomatic forms to classic presentation of malabsorption with diarrhea and abdominal cramps. Celiac disease can also present with several other concomitant disorders (at the time of diagnosis or during the course of celiac disease) such as: type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, thyroid disorders, nutritional deficiencies, and gram-negative sepsis. We present a 57-year-old female with past medical history of rheumatoid arthritis, who presented to the emergency department with a complaint of chronic diarrhea, complicated by gram-negative sepsis. The family history of the patient was significant for celiac disease, type 1 diabetes, and rheumatoid arthritis. The patient was closely monitored and treated appropriately. In this case-based review, we explore different associated conditions of celiac disease in the literature, as well as the patient's risk of developing malignancy.
BIOTECHNOLOGY OF PRESERVATION OF THE RARE WILD ORCHID OF UKRAINIAN FLORA Ophrys sphegodes subsp. mammosa (Desf. Soó ex E. Nelson

Directory of Open Access Journals (Sweden)

Sheiko E. A.

2015-08-01

Full Text Available The aim of the work was to determine the optimal conditions for callusogenesis in (in vitro cultures of ovules, ovaries and anthers from vanishing wild orchid Ophrys sphegodes subsp. mammosa (Desf. Soó ex E. Nelson followed by using of the obtained callus tissue to develop micropropagation techniques and conservation ex situ. In this study we used biotechnological (cultivation of explants in vitro and microscopic (making temporary preparations, light microscopy, cytomorphological callus tissue analysis methods. Nutrient media with optimal concentrations of growth regulators were selected and calluses derived from the generative organs were obtained (we used for ovaries Murashige–Skoog medium that contains 2.5 mg/l 6 of BAP and 1.5 mg/l of 2,4-D; for ovules — nutrient medium Nitsch and Nitsch containing 2.0 mg/l of 6-benzyladenine and 2.5 mg/l of 2,4-D, for the explants from anther — nutrient medium Nitsch and Nitsch containing 3 mg/l 6 of 6- benzyladenine and 2.5 mg/l of IBA. Cytomorphological analysis reveals the presence of meristematic foci in calluses. It indicates the beginning of the secondary processes of differentiation in the callus tissue. The results may be used in further investigations to obtain O. sphegodes regenerated plants from callus.
The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

CERN Multimedia

Maximilien Brice

2008-01-01

The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.
IgG4-Related Disease: A Multispecialty Condition

Directory of Open Access Journals (Sweden)

Iuri Usêda Santana

2014-01-01

Full Text Available IgG4-related disease (IgG4-RD is a recently recognized group of conditions, characterized by tumor-like swelling of involved organs, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, variable degrees of fibrosis, and elevated serum IgG4 concentrations. Currently IgG4-RD is recognized as a systemic condition that can affect several organs and tissues. Herein we report the case of a 34-year-old male patient who was admitted to our hospital with diffuse abdominal pain, weight loss, and painful stiffness in his neck. He had a history of tumoral mass of the left maxillary region, right palpebral ptosis with protrusion of the eyeball, and chronic dry cough for about 6 years. Laboratory tests revealed polyclonal hypergammaglobulinemia and increased serum IgG4 levels. Immunohistochemical staining of the maxillary biopsy was compatible with IgG4-RD. He had an excellent response to corticosteroid therapy. This case highlights that IgG4-RD should be included in the differential diagnosis with multisystem diseases.
Notes on dissimulation in the theatre of Nelson Rodrigues: the case of O beijo no asfalto

Directory of Open Access Journals (Sweden)

Adauto Locatelli Taufer

2013-12-01

Full Text Available The paradigms that determine what is true and false are the reason for to investigate aspects that represent the dissimulation in O beijo no asfalto, by Nelson Rodrigues. Starobinski’s investigations, for whom the society is built upon the solid bases of the conventions that determine how to be and how to act in the social complex mesh; Michel Foucault, for whom the limit between falsehood and truth is a dangerous zone, thanks to the multiple facets that cover the lie -, constitute on the theoretical presuppositions that form the base to the analysis inside. Assuming that the mask is a simulacrum, in fact, it acts as if it was a kind of entry and exit portal that we have in order to travel the maze of social relations. The main goal of this article is to point the different social masks used by “rodriguean” characters on the referred work.
Acquired heart conditions in adults with congenital heart disease: a growing problem.

Science.gov (United States)

Tutarel, Oktay

2014-09-01

The number of adults with congenital heart disease is increasing due to the great achievements in the field of paediatric cardiology, congenital heart surgery and intensive care medicine over the last decades. Mortality has shifted away from the infant and childhood period towards adulthood. As congenital heart disease patients get older, a high prevalence of cardiovascular risk factors is encountered similar to the general population. Consequently, the contribution of acquired morbidities, especially acquired heart conditions to patient outcome, is becoming increasingly important. Therefore, to continue the success story of the last decades in the treatment of congenital heart disease and to further improve the outcome of these patients, more attention has to be given to the prevention, detection and adequate therapy of acquired heart conditions. The aim of this review is to give an overview about acquired heart conditions that may be encountered in adults with congenital heart disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Construção de curva de juros de debêntures no mercado brasileiro utilizando a parametrização de Nelson-Siegel

Directory of Open Access Journals (Sweden)

Vinícius Gomes Araújo

2013-03-01

Full Text Available O objetivo nesse trabalho é a construção da Estrutura a Termo de Taxa de Juros (ETTJ das debêntures que se encontram disponíveis no mercado brasileiro, usando o modelo Nelson-Siegel (1987. As curvas de juros são divididas de acordo com o tipo de indexador e com a classificação de risco atribuída às debêntures. Por fim, foi possível mensurar o spread que existe entre o mercado de títulos privados (debêntures e os títulos públicos.
Income-related inequalities in diseases and health conditions over the business cycle

OpenAIRE

Asgeirsdottir, Tinna Laufey; Hildur Margrét, Jóhannsdóttir

2017-01-01

How business cycles affect income-related distribution of diseases and health disorders is largely unknown. We examine how the prevalence of thirty diseases and health conditions is distributed across the income spectrum using survey data collected in Iceland in 2007, 2009 and 2012. Thus, we are able to take advantage of the unusually sharp changes in economic conditions in Iceland during the Great Recession initiated in 2008 and the partial recovery that had already taken place by 2012 to an...

Unusual climatic conditions and infectious diseases: observations made by Hippocrates.

Science.gov (United States)

Falagas, Matthew E; Bliziotis, Ioannis A; Kosmidis, John; Daikos, George K

2010-12-01

About 2500 years ago, Hippocrates made noteworthy observations about the influence of climate on public health. He believed that people living in cities with different climate may suffer from different diseases. Hippocrates also observed that abrupt climatic changes or unusual weather conditions affect public health, especially the incidence and severity of various infectious diseases, including gastrointestinal infections, tuberculosis, and central nervous system infections. We believe that Hippocrates' scientific observations are great early historic examples that stress to modern infectious diseases researchers and clinicians the need to study intensively the effect of the occurring global climate changes to infectious diseases in order to help in the prevention of possible epidemics of infections. Copyright © 2009 Elsevier España, S.L. All rights reserved.
Challenging Ulcerative Vulvar Conditions: Hidradenitis Suppurativa, Crohn Disease, and Aphthous Ulcers.

Science.gov (United States)

Stewart, Kristen M A

2017-09-01

This article discusses the clinical evaluation and approach to patients with 3 complex ulcerative vulvar conditions: hidradenitis suppurativa, metastatic Crohn disease of the vulva, and aphthous ulcers. These conditions are particularly challenging to medical providers because, although each is known to present with nonspecific examination findings that vary in morphology, the predominance of the diagnosis is based on clinical examination and exclusion of a wide variety of other conditions. Care of patients with these conditions is further complicated by the lack of therapeutic data and the significant impact these conditions have on quality of life. Copyright © 2017 Elsevier Inc. All rights reserved.
Aplicación del modelo polinomial en la evaluación de la uniformidad de riego del aspersor autocompensado Nelson R10

Directory of Open Access Journals (Sweden)

Fanny del Rocío Rodríguez-Jarama

2015-01-01

Full Text Available Los métodos de evaluación de la uniformidad de riego estiman las condiciones hidráulicas de funcionamiento del sistema de riego y su influencia en la aplicación de láminas de agua, con base en las necesidades hídricas de un cultivo. El modelo de evaluación utilizado en la presente investigación fue el polinomial. El ensayo evaluó el funcionamiento del sistema de riego con 4 presiones de operación distintas, medidas a la salida de la válvula del módulo de riego, y por cada presión de operación se tomaron 16 datos de caudales, en 5 módulos de riego instalado con el aspersor autocompensado Nelson R10. Como resultado se obtuvo el coeficiente de uniformidad, el coeficiente de distribución, el área adecuadamente irrigada y el factor de adecuación del riego. Uno de los principales resultados fue la no existencia de diferencia significativa entre las presiones mientras esta se mantengan en el rango de autocompensación; por otro lado, en el coeficiente de distribución sí existen diferencias significativas entre los tratamientos, a pesar de que todos dan valores mayores al 90%, en contraste con los porcentajes del área relativa adecuadamente regada, que no superan el 50% en ninguno de los tratamientos. Con lo anterior se pudo validar y verificar que el aspersor Nelson R10 autocompensado, una vez instalado en campo, cumple con las características técnicas de operación expuestas en el catálogo del fabricante, sin embargo, sí se debe manejar y controlar la lámina de riego aplicada.
Conditional predictive inference for online surveillance of spatial disease incidence

Science.gov (United States)

Corberán-Vallet, Ana; Lawson, Andrew B.

2012-01-01

This paper deals with the development of statistical methodology for timely detection of incident disease clusters in space and time. The increasing availability of data on both the time and the location of events enables the construction of multivariate surveillance techniques, which may enhance the ability to detect localized clusters of disease relative to the surveillance of the overall count of disease cases across the entire study region. We introduce the surveillance conditional predictive ordinate as a general Bayesian model-based surveillance technique that allows us to detect small areas of increased disease incidence when spatial data are available. To address the problem of multiple comparisons, we incorporate a common probability that each small area signals an alarm when no change in the risk pattern of disease takes place into the analysis. We investigate the performance of the proposed surveillance technique within the framework of Bayesian hierarchical Poisson models using a simulation study. Finally, we present a case study of salmonellosis in South Carolina. PMID:21898522
Pituitary tumors containing cholecystokinin

DEFF Research Database (Denmark)

Rehfeld, J F; Lindholm, J; Andersen, B N

1987-01-01

We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained......'s disease and 7 acromegaly with adenomas containing ACTH. The cholecystokinin peptides from the tumors were smaller and less sulfated than cholecystokinin from normal pituitary glands. We conclude that ACTH-producing pituitary cells may also produce an altered form of cholecystokinin....
O acervo de mosquitos (Diptera, Culicidae de Nelson L. Cerqueira na Coleção de Invertebrados do Instituto Nacional de Pesquisas da Amazônia, Manaus, Brasil The Nelson L. Cerqueira Mosquito Collection (Diptera, Culicidae in the Invertebrate Collection of the Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil

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Rosa Sá Gomes Hutchings

2005-03-01

Full Text Available Registra-se a descoberta de espécimes de mosquitos que pertenciam a Nelson L. Cerqueira, e estão sendo depositados na coleção de Invertebrados do Instituto Nacional de Pesquisas da Amazônia. A coleção contém 2.046 espécimes adultos e 387 lâminas representando 261 espécies, 22 gêneros, incluindo 51 parátipos de 34 espécies. Mais de 90% dos espécimes foram coletados no Brasil dos quais metade são do Estado do Amazonas. As espécies representadas neste acervo são listadas indicando o número de espécimes para cada tipo de preparação e as localidades de coleta. O material tipo também é listado, incluindo os dados dos rótulos de identificação e de procedência, bem como outras informações pertinentes.The discovery of mosquito specimens that belonged to Nelson L. Cerqueira, which are being deposited in the Instituto Nacional de Pesquisas da Amazônia Invertebrate Collection, is reported. The collection contains 2,046 adult specimens and 387 slide preparations representing 261 species, 22 genera, including 51 paratypes of 34 species. More than 90% of the specimens were collected in Brazil of which half are from the State of Amazonas. A list of the species represented in this collection is provided indicating the number of specimens for each type of preparation and the collecting localities. The type specimens are also listed including their label data and other pertinent information.
Control of Root Rot and Wilt Diseases of Roselle under Field Conditions

Science.gov (United States)

Hassan, Naglaa; Elsharkawy, Mohsen Mohamed; Shimizu, Masafumi

2014-01-01

Roselle (Hibiscus sabdariffa L.) is one of the most important medicinal crops in many parts of the world. In this study, the effects of microelements, antioxidants, and bioagents on Fusarium oxysporum, F. solani, and Macrophomina phaseolina, the causal pathogens of root rot and wilt diseases in roselle, were examined under field conditions. Preliminary studies were carried out in vitro in order to select the most effective members to be used in field control trials. Our results showed that microelements (copper and manganese), antioxidants (salicylic acid, ascorbic acid, and EDTA), a fungicide (Dithane M45) and biological control agents (Trichoderma harzianum and Bacillus subtilis) were significantly reduced the linear growth of the causal pathogens. Additionally, application of the previous microelements, antioxidants, a fungicide and biological control agents significantly reduced disease incidence of root rot and wilt diseases under field conditions. Copper, salicylic acid, and T. harzianum showed the best results in this respect. In conclusion, microelements, antioxidants, and biocontrol agents could be used as alternative strategies to fungicides for controlling root rot and wilt diseases in roselle. PMID:25606010
Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.

CERN Multimedia

Maximilien Brice

2008-01-01

Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.
Ménière's Disease and Underlying Medical and Mental Conditions: Towards Factors Contributing to the Disease.

Science.gov (United States)

Mohamed, Shwan; Khan, Imran; Iliodromiti, Stamatina; Gaggini, Margaret; Kontorinis, Georgios

2016-01-01

To investigate the relation of Ménière's disease (MD) with medical comorbidity or mental conditions. Demographic data, medical and mental comorbidities were retrospectively collected and compared from 3 groups of 30 patients each: a group with patients with definite MD, a second one with patients with vestibulopathies other than MD (non-Ménière's vertigo, NMV) and a third one with patients without any vestibular symptoms (control). The level of significance was set at 0.05. The prevalence of mental conditions was 26.7, 23.3 and 6.7% for the MD, the NMV and the control group, respectively. Medical comorbidity was found in 80% of patients in the MD, 63% in the NMV and 20% in the control group. Arthritis was encountered in 8 patients with MD, 3 with NMV and none from the control group. The differences in prevalence of mental disease, comorbidities and arthritis between the MD and the control group were statistically significant (p = 0.02, p disease. © 2016 S. Karger AG, Basel.
Tradição, tragicidade e crítica social em Dorotéia, a “farsa irresponsável” de Nelson Rodrigues

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Sandra Amélia Luna Cirne de Azevêdo

2014-07-01

Full Text Available http://dx.doi.org/10.5007/2176-8552.2013n16p163 A verossimilhança sempre foi amplamente explorada pela imaginação artística. Poetas trágicos e cômicos tramaram situações as mais criativas, buscando mover o público ao riso ou às lágrimas. Tradicionalmente, entretanto, recaem limites sobre as representações dramáticas, a depender dos efeitos que os autores pretendem provocar. Assim, ainda que eventos impossíveis tenham participado da tragédia desde suas origens, e ainda que o humor tenha sido ocasionalmente acolhido nas tramas, o tratamento sério da ação sempre foi exigência da forma, de maneira a que o trágico não se fizesse cômico. Com o passar dos séculos, dramaturgos desafiariam as definições de tragédia e comédia, preparando as bases para o drama social. A dramatização de conflitos da vida burguesa rapidamente absorveria um amplo espectro de tons emocionais, abolindo convenções antigas em favor de um gênero que se quer lócus privilegiado de crítica social. O trágico poderia agora ser dramatizado sob perspectivas as mais diversas, inclusive farsescas. Este ensaio examina a tragicidade na peça Dorotéia, de Nelson Rodrigues, focalizando as relações da obra com a tradição e considerando, através do conceito de “dispositivo” formulado por Agamben, estratégias utilizadas pelo dramaturgo para produzir uma crítica sarcástica a valores e instituições sociais. Palavras-chave: Nelson Rodrigues; Dorotéia; Teoria do Drama; Tragédia Moderna; Teatro Brasileiro
Flow instability research on steam generator with straight double-walled heat transfer tube for FBR. Pressure drop under high pressure condition

International Nuclear Information System (INIS)

Liu, Wei; Tamai, Hidesada; Yoshida, Hiroyuki; Takase, Kazuyuki; Hayafune, Hiroki; Futagami, Satoshi; Kisohara, Naoyuki

2008-01-01

For the Steam Generator (SG) with straight double-walled heat transfer tube that used in sodium cooled Faster Breeder Reactor, flow instability is one of the most important items need researching. As the first step of the research, thermal hydraulics experiments were performed under high pressure condition in JAEA with using a straight tube. Pressure drop, heat transfer coefficients and void fraction data were derived. This paper evaluates the pressure drop data with TRAC-BF1 code. The Pffan's correlation for single phase flow and the Martinelli-Nelson's two-phase flow multiplier are found can be well predicted the present pressure drop data under high pressure condition. (author)
Os cinco sentidos, tradução de Nelson Pimenta: reflexões sobre poesia surda no Youtube

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Carla Cristina Gaia dos Santos

2017-12-01

Full Text Available As Comunidades Surdas encontram nas tecnologias comunicacionais atuais grandes aliados para divulgação e perpetuação de sua literatura, desconstruindo fronteiras geográficas e sociais que, muitas vezes, os isolavam uns dos outros. Se desde o advento da impressa a escrita tem assumido o papel central de transmissão e construção do conhecimento nas mais diversas áreas do saber, a época da comunicação virtual chega para nos lembrar de outras formas nem tão privilegiadas de significar e de comunicar. Através da internet os Surdos partilham suas histórias, poesias, piadas e muito mais. Baseando-nos em pesquisadores como Lévy (2015, Kress (2003 e Lemke (2010, o presente artigo objetiva refletir sobre a poesia Cinco Sentidos, tradução de Nelson Pimenta para a língua brasileira de sinais de Five Senses, do poeta briânico Paul Scott, disponível no ambiente virtual YouTube.
Restrictions of Non Associated Plastic Flow Laws Imposed by Thermodynamics and Uniqueness

Science.gov (United States)

1986-05-20

loading. Difficulties in using constitutive relations which violate the continuity condition have been reported in the past (Nelson and Baladi , 1977...of Thermodynamics in Mechanics of Materials," Energy. 5. 771. Nelson, I., and G. Y. Baladi (1977). "Outrunning Ground Shock Computed with Different
The complete mitochondrial genome of the gall-forming fly, Fergusonina taylori Nelson and Yeates (Diptera: Fergusoninidae).

Science.gov (United States)

Nelson, Leigh A; Cameron, Stephen L; Yeates, David K

2011-10-01

The monogeneric family Fergusoninidae consists of gall-forming flies that, together with Fergusobia (Tylenchida: Neotylenchidae) nematodes, form the only known mutualistic association between insects and nematodes. In this study, the entire 16,000 bp mitochondrial genome of Fergusonina taylori Nelson and Yeates was sequenced. The circular genome contains one encoding region including 27 genes and one non-coding A+T-rich region. The arrangement of the protein-coding, ribosomal RNA (rRNA) and transfer RNA (tRNA) genes was the same as that found in the ancestral insect. Nucleotide composition is highly A+T biased. All of the protein initiation codons are ATN, except for nad1 which begins with TTT. All 22 tRNA anticodons of F. taylori match those observed in Drosophila yakuba, and all form the typical cloverleaf structure except for tRNA-Ser((AGN)) which lacks a dihydrouridine (DHU) arm. Secondary structural features of the rRNA genes of Fergusonina are similar to those proposed for other insects, with minor modifications. The mitochondrial genome of Fergusonina presented here may prove valuable for resolving the sister group to the Fergusoninidae, and expands the available mtDNA data sources for acalyptrates overall.
Current status of adrenalectomy for Cushing's disease

International Nuclear Information System (INIS)

Brunicardi, F.C.; Rosman, P.M.; Lesser, K.L.; Andersen, D.K.

1985-01-01

To evaluate the current use of adrenalectomy in the treatment of Cushing's disease, we reviewed seven consecutive patients who have undergone adrenalectomy for Cushing's disease at this medical center during 1983 to 1984. Seventy-one percent (5/7) had pituitary, or type I, Cushing's disease, while 29% (2/7) had adrenal, or type II, Cushing's disease from either an adenoma or an adrenocortical carcinoma. Presenting signs and symptoms, either initially or at the time of recurrence, were typical of Cushing's syndrome. Four of five patients with type I disease had recurrent disease after transphenoidal hypophysectomy, bilateral adrenalectomy, or unilateral adrenalectomy. In three of five patients, medical therapy of hypercortisolism was abandoned because of adverse side effects. Preoperative evaluation in all patients included cortisol and ACTH levels, dexamethasone suppression tests, and computerized tomography (both abdominal and head). In patients with a prior history of adrenalectomy, radiocholesterol scans were also performed and were useful. Angiographic procedures were not required in these patients. In patients with type I disease, posterior operative approaches were used. In patients with type II disease, an anterolateral approach was used. Posterolateral incisions are preferred over Hugh-Young incisions and provide better exposure with a reduced risk of poor wound healing. Morbidity and mortality included one death and three nonhealing wounds. In the six surviving patients, symptoms resolved with variable frequency. Findings suggestive of Nelson's syndrome (hyperpigmentation) have occurred in two patients; serial computerized tomographic scans fail to reveal evidence of pituitary tumors
Artificial Neural Network Application in the Diagnosis of Disease Conditions with Liver Ultrasound Images

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Karthik Kalyan

2014-01-01

Full Text Available The preliminary study presented within this paper shows a comparative study of various texture features extracted from liver ultrasonic images by employing Multilayer Perceptron (MLP, a type of artificial neural network, to study the presence of disease conditions. An ultrasound (US image shows echo-texture patterns, which defines the organ characteristics. Ultrasound images of liver disease conditions such as “fatty liver,” “cirrhosis,” and “hepatomegaly” produce distinctive echo patterns. However, various ultrasound imaging artifacts and speckle noise make these echo-texture patterns difficult to identify and often hard to distinguish visually. Here, based on the extracted features from the ultrasonic images, we employed an artificial neural network for the diagnosis of disease conditions in liver and finding of the best classifier that distinguishes between abnormal and normal conditions of the liver. Comparison of the overall performance of all the feature classifiers concluded that “mixed feature set” is the best feature set. It showed an excellent rate of accuracy for the training data set. The gray level run length matrix (GLRLM feature shows better results when the network was tested against unknown data.
Artificial Neural Network Application in the Diagnosis of Disease Conditions with Liver Ultrasound Images

Science.gov (United States)

Lele, Ramachandra Dattatraya; Joshi, Mukund; Chowdhary, Abhay

2014-01-01

The preliminary study presented within this paper shows a comparative study of various texture features extracted from liver ultrasonic images by employing Multilayer Perceptron (MLP), a type of artificial neural network, to study the presence of disease conditions. An ultrasound (US) image shows echo-texture patterns, which defines the organ characteristics. Ultrasound images of liver disease conditions such as “fatty liver,” “cirrhosis,” and “hepatomegaly” produce distinctive echo patterns. However, various ultrasound imaging artifacts and speckle noise make these echo-texture patterns difficult to identify and often hard to distinguish visually. Here, based on the extracted features from the ultrasonic images, we employed an artificial neural network for the diagnosis of disease conditions in liver and finding of the best classifier that distinguishes between abnormal and normal conditions of the liver. Comparison of the overall performance of all the feature classifiers concluded that “mixed feature set” is the best feature set. It showed an excellent rate of accuracy for the training data set. The gray level run length matrix (GLRLM) feature shows better results when the network was tested against unknown data. PMID:25332717
Patient-Centred Care of Older Adults With Cardiovascular Disease and Multiple Chronic Conditions.

Science.gov (United States)

Kim, Dae Hyun; Rich, Michael W

2016-09-01

Multimorbidity, defined as the presence of 2 or more chronic conditions, is common among older adults with cardiovascular disease. These individuals are at increased risk for poor health outcomes and account for a large proportion of health care utilization. Clinicians are challenged with the heterogeneity of this population, the complexity of the treatment regimen, limited high-quality evidence, and fragmented health care systems. Each treatment recommended by a clinical practice guideline for a single cardiovascular disease might be rational, but the combination of all evidence-based recommendations can be impractical or even harmful to individuals with multimorbidity. These challenges can be overcome with a patient-centred approach that incorporates the individual's preferences, relevant evidence, the overall and condition-specific prognosis, clinical feasibility of treatments, and interactions with other treatments and coexisting chronic conditions. The ultimate goal is to maximize benefits and minimize harms by optimizing adherence to the most essential treatments, while acknowledging trade-offs between treatments for different health conditions. It might be necessary to discontinue therapies that are not essential or potentially harmful to decrease the risk of drug-drug and drug-disease interactions from polypharmacy. A decision to initiate, withhold, or stop a treatment should be on the basis of the time horizon to benefits vs the individual's prognosis. In this review, we illustrate how cardiologists and general practitioners can adopt a patient-centred approach to focus on the aspects of cardiovascular and noncardiovascular health that have the greatest effect on functioning and quality of life in older adults with cardiovascular disease and multimorbidity. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Power System Reliability Assessment by Analysing Voltage Dips on the Blue Horizon Bay 22KV Overhead Line in the Nelson Mandela Bay Municipality

Science.gov (United States)

Lamour, B. G.; Harris, R. T.; Roberts, A. G.

2010-06-01

Power system reliability problems are very difficult to solve because the power systems are complex and geographically widely distributed and influenced by numerous unexpected events. It is therefore imperative to employ the most efficient optimization methods in solving the problems relating to reliability of the power system. This paper presents a reliability analysis and study of the power interruptions resulting from severe power outages in the Nelson Mandela Bay Municipality (NMBM), South Africa and includes an overview of the important factors influencing reliability, and methods to improve the reliability. The Blue Horizon Bay 22 kV overhead line, supplying a 6.6 kV residential sector has been selected. It has been established that 70% of the outages, recorded at the source, originate on this feeder.
Gisela Cramer y Ursula Prutsch, editoras. ¡Américas unidas! Nelson A. Rockefeller’s Office of Inter-American Affairs (1940-46

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David Andrew Corcoran

2013-07-01

Full Text Available Un tema muy poco conocido y con poca frecuencia estudiado es la constitución de la Oficina de Asuntos Interamericanos (OIAA, en inglés, que orquesto una reestructuración de las relaciones entre Estados Unidos y América Latina durante de la Segunda Guerra Mundial. Abandonando de esta manera los limites de la diplomacia tradicional (gobierno a gobierno, los programas OIAA pusieron al gobierno de EE.UU. y a sus ciudadanos por primera vez en contacto directo con sectores amplios del pueblo latinoamericano. Bajo la dirección del joven Nelson Rockefeller y con la clara intención de frenar la influencia del poder nazi y del eje en la región, la OIAA dio sustento a la política del buen vecino.

Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Science.gov (United States)

Jepsen, Søren; Caton, Jack G; Albandar, Jasim M; Bissada, Nabil F; Bouchard, Philippe; Cortellini, Pierpaolo; Demirel, Korkud; de Sanctis, Massimo; Ercoli, Carlo; Fan, Jingyuan; Geurs, Nicolaas C; Hughes, Francis J; Jin, Lijian; Kantarci, Alpdogan; Lalla, Evanthia; Madianos, Phoebus N; Matthews, Debora; McGuire, Michael K; Mills, Michael P; Preshaw, Philip M; Reynolds, Mark A; Sculean, Anton; Susin, Cristiano; West, Nicola X; Yamazaki, Kazuhisa

2018-06-01

A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium. The aim of this working group was to review and update the 1999 classification with regard to these diseases and conditions, and to develop case definitions and diagnostic considerations. Discussions were informed by four reviews on 1) periodontal manifestions of systemic diseases and conditions; 2) mucogingival conditions around natural teeth; 3) traumatic occlusal forces and occlusal trauma; and 4) dental prostheses and tooth related factors. This consensus report is based on the results of these reviews and on expert opinion of the participants. Key findings included the following: 1) there are mainly rare systemic conditions (such as Papillon-Lefevre Syndrome, leucocyte adhesion deficiency, and others) with a major effect on the course of periodontitis and more common conditions (such as diabetes mellitus) with variable effects, as well as conditions affecting the periodontal apparatus independently of dental plaque biofilm-induced inflammation (such as neoplastic diseases); 2) diabetes-associated periodontitis should not be regarded as a distinct diagnosis, but diabetes should be recognized as an important modifying factor and included in a clinical diagnosis of periodontitis as a descriptor; 3) likewise, tobacco smoking - now considered a dependence to nicotine and a chronic relapsing medical disorder with major adverse effects on the periodontal supporting tissues - is an important modifier to be included in
Technology of physical rehabilitation of children with bronchopulmonary diseases in the conditions of hospitalization

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Nataliya Ivasyk

2016-10-01

Full Text Available Purpose: the development of technology of physical rehabilitation of children with bronchopulmonary diseases. Material & Methods: general scientific – analysis, conception and generalization, synthesis, comparison, abstraction. Results: technology of physical rehabilitation for children with bronchopulmonary diseases (BD, which is directed to the restoration and the development of physiological functions of a child, the prevention of synchronization of sharp processes, the elimination of negative changes in health of a child, the assistance in creation of conditions for adaptation to changes as a result of disease in life situations, is offered. Conclusions: the program and its activity including basic and variable components is the compound of the offered technology of physical rehabilitation for children with BD in the conditions of hospitalization.
Predictors of activity and participation across neurodegenerative conditions: a comparison of people with motor neurone disease, multiple sclerosis and Parkinson's disease.

Science.gov (United States)

Morley, David; Dummett, Sarah; Kelly, Laura; Fitzpatrick, Ray; Jenkinson, Crispin

2018-02-17

Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predictors of activity and participation in people with motor neurone disease (MND), people with multiple sclerosis (MS) and people with Parkinson's Disease (PD). The Oxford Participation and Activities Questionnaire (Ox-PAQ) and Medical Outcomes Study 36-Item Short Form Survey (MOS SF-36) were administered by postal survey to 386 people with a confirmed diagnosis of MND, MS or PD. Data analyses focused on stepwise regression analyses in order to identify predictors of activity and participation in the three conditions assessed. Three hundred and thirty four participants completed the survey, a response rate of 86.5%. Regression analyses identified multiple predictors of activity and participation dependent on Ox-PAQ domain and disease group, the most prominent being social and physical functioning as measured by the MOS SF-36. Results indicate that the physical and social consequences of neurological illness are of greatest relevance to people experiencing the conditions assessed. Whilst the largely inevitable physical implications of disease take hold, emphasis should be placed on the avoidance of social withdrawal and isolation, and the maintenance of social engagement should become a significant priority.
Food insecurity among students living with HIV: Strengthening safety nets at the Nelson Mandela Metropolitan University, South Africa.

Science.gov (United States)

Steenkamp, L; Goosen, A; Venter, D; Beeforth, M

2016-12-01

The HIV prevalence in South Africa among students at higher education institutions (HEIs) in 2008 was reported to be 3.4%, with the highest HIV prevalence found in the Eastern Cape Province. Students at these facilities are also increasingly affected by socio-economic constraints that may impact on food security. Little is known about the impact of food insecurity on HIV-infected students in HEIs in South Africa. The purpose of this paper is to describe food insecurity and the nutritional status among HIV-infected students on the Nelson Mandela Metropolitan University campuses in South Africa, as well as current initiatives to strengthen the safety nets for food-insecure students. This descriptive, cross-sectional survey was conducted among a convenience sample of known HIV-infected, registered students (n = 63), older than 18 years of age and managed as part of the Campus Health Service antiretroviral therapy (ART) programme. Ethical approval for the study was obtained from the Research Ethics Committee (NMMU) and participants were included in the sample after providing written, informed consent. Findings indicate that food insecurity was common with more than 60% of the sample reporting food insecurity at the household level during the previous month. Of the sample, 51% were classified as being either overweight or obese. Although food insecurity did not contribute to weight loss in our sample, food-insecure students were more likely to consume inadequate amounts of vitamins and minerals, especially antioxidants that are important in supporting the immune system. Food insecurity has been identified as affecting the majority of HIV-infected students in this study, especially regarding their difficulty in accessing nutritious foods. As overweight and obesity also seem to threaten the health and future well-being of the students, appropriate management of the overweight individuals and those with obesity should be instituted in order to prevent the development
Potential role of coenzyme Q10 in health and disease conditions

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Rodick TC

2018-02-01

Full Text Available Taylor C Rodick,1 Donna R Seibels,2 Jeganathan Ramesh Babu,1 Kevin W Huggins,1 Guang Ren,3 Suresh T Mathews2 1Department of Nutrition, Dietetics, & Hospitality Management, Auburn University, Auburn, 2Department of Nutrition and Dietetics, Samford University, 3Medicine-Endocrinology, Diabetes & Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Coenzyme Q10 (CoQ10, an endogenously produced compound, is found in all human cells. Within the mitochondria, it plays a substantial role in energy production by acting as a mobile electron carrier in the electron transport chain. Outside the mitochondria, it acts as an excellent antioxidant by sequestering free radicals and working synergistically with other antioxidants, including vitamin E. Dietary contribution is limited, making endogenous production the primary source for optimal function. Now widely available as an over-the-counter supplement, CoQ10 has gained attention for its possible therapeutic use in minimizing the outcomes of certain metabolic diseases, notably cardiovascular disease, diabetes, neurodegenerative disease, and cancer. Research has shown positive results in subjects supplemented with CoQ10, especially in relation to upregulating antioxidant capability. Emerging research suggests beneficial effects of CoQ10 supplementation in individuals on statin medications. CoQ10 supplementation in individuals participating in strenuous exercise seems to exert some beneficial effects, although the data are conflicting with other types of physical activity. This broad review of current CoQ10 literature, while outlining its physiological/functional significance in health and disease conditions, also offers a dietitian’s perspective on its potential use as a supplement in the promotion of health and management of disease conditions. Keywords: coenzyme Q, antioxidant, oxidative stress, dietary supplement, statin
Oral and non oral diseases and conditions associated with bad breath.

Science.gov (United States)

Migliario, M; Rimondini, L

2011-03-01

The causes of bad breath are numerous and related to conditions dependent or not on oral and general health. The aim of our observational study is the assessment of the simultaneous relationships between halitosis, oral and/or nonoral diseases, and lifestyles using the principal components analysis of categorical data (CATPCA) to identify the main components involved in the detection of the symptom. A sample of 192 patients, who requested general dental examination at the Dental Clinic, participated at the study. Alimentary and voluptuary habits, general health information, drugs assumption, the status of teeth and intraoral medical devices including fillers, lesions of the oral mucosa, tongue coating score (TCS), plaque index (PI), probing bleeding index (PBI) and organoleptic tests were all evaluated. Data were analysed using CATPCA model. A strong relationship between halitosis and plaque, probing bleeding and tongue coating indexes was observed, whereas incongruous fillers, prostheses, systemic pathologies or diet were not clearly associated with halitosis probably because their effects on breath were clinically sheltered by the periodontal condition. The data of our observational study confirm that halitosis is more indicative of tongue coating and periodontal disease, rather than other oral and non oral associated conditions, like systemic pathologies or specific habits of life.
Conditional dependence between tests affects the diagnosis and surveillance of animal diseases

DEFF Research Database (Denmark)

Gardner, I.A.; Stryhn, Henrik; Lind, Peter

2000-01-01

Dependence between the sensitivities or specificities of pairs of tests affects the sensitivity and specificity of tests when used in combination. Compared with values expected if tests are conditionally independent, a positive dependence in test sensitivity reduces the sensitivity of parallel te...... for toxoplasmosis and brucellosis in swine, and Johne's disease in cattle to illustrate calculation methods and to indicate the likely magnitude of the dependence between serologic tests used for diagnosis and surveillance of animal diseases....
Peripartum hysterectomy: two years experience at Nelson Mandela Academic hospital, Mthatha, Eastern Cape South Africa.

Science.gov (United States)

Wandabwa, J N; Businge, C; Longo-Mbenza, B; Mdaka, M L; Kiondo, P

2013-06-01

Obstetric haemorrhage is the leading direct cause of maternal mortality in South Africa. To determine the incidence, indications, associations and maternal outcomes of emergency peripartum hysterectomies. A descriptive and retrospective analysis of patients who had peripartum hysterectomy between 1(st) February 2007 and 31(st) January 2009 in Nelson Mandela Academic Hospital at Mthatha city. The incidence of 0.95% of peripartum hysterectomies (n=63 or 9.5/1000 births) increased with the increasing maternal age from 0.121% at age of less than 20 years to 0.5% at age more or equal to 30 years. Similarly the incidence increased with parity from 0.332% for Primiparity to 0.468% at parity of four or more. The indications for the operation were uterine atony 19/63 (30.2%), secondary haemorrhage/puerperal sepsis 17/63 (27%) and ruptured uterus 16/63 (23.4%). The main intra operative complication was haemorrhage 13/63 (20.6%). Repeat laparotomy was done in 10/63 (15%) of patients due to haemorrhage. Admission to intensive care unit was 25/63 (39.7%). The case specific mortality rate was of 19 % (n=12). The main causes of death were hypovolaemic shock and septicemia. The incidence of peripartum hysterectomies was high and was associated with ruptured uterus and puerperal sepsis which are preventable.
Public support for neonatal screening for Pompe disease, a broad-phenotype condition

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Weinreich Stephanie

2012-03-01

Full Text Available Abstract Background Neonatal screening for Pompe disease has been introduced in Taiwan and a few U.S. states, while other jurisdictions including some European countries are piloting or considering this screening. First-tier screening flags both classic infantile and late-onset Pompe disease, which challenges current screening criteria. Previously, advocacy groups have sometimes supported expanded neonatal screening more than professional experts, while neutral citizens' views were unknown. This study aimed to measure support for neonatal screening for Pompe disease in the general public and to compare it to support among (parents of patients with this condition. The study was done in the Netherlands, where newborns are not currently screened for Pompe disease. Newborn screening is not mandatory in the Netherlands but current uptake is almost universal. Methods A consumer panel (neutral group and (parents of patients with Pompe disease (Pompe group were sent information and a questionnaire. Responses were analyzed of 555 neutral and 58 Pompe-experienced informants who had demonstrated sufficient understanding. Results 87% of the neutral group and 88% of the Pompe group supported the introduction of screening (95% CI of difference -10 to 7%. The groups were similar in their moral reasoning about screening and acceptance of false positives, but the Pompe-experienced group expected greater benefit from neonatal detection of late-onset disease. Multivariate regression analysis controlling for demographics confirmed that approval of the introduction of screening was independent of having (a child with Pompe disease. Furthermore, respondents with university education, regardless of whether they have (a child with Pompe disease, were more likely to be reluctant about the introduction of screening than those with less education, OR for approval 0.29 (95% CI 0.18 to 0.49, p Conclusions This survey suggests a rather high level of support for newborn
A characterization of Markovian homogeneous multicomponent Gaussian fields

International Nuclear Information System (INIS)

Ekhaguere, G.O.S.

1980-01-01

Necessary and sufficient conditions are given for a certain class of homogeneous multicomponent Gaussian generalized stochastic fields to possess a Markov property equivalent to Nelson's. The class of Markov fields so characterized has a as a cubclass the class of Markov fields which lead by Nelson's Reconstruction Theorem to some covariant (free) quantum fields. (orig.)
A cinema of presence and proximity: Gunvor Nelson's collage films and the aesthetics of the signaletic material before the electronic signal

Directory of Open Access Journals (Sweden)

John Sundholm

2012-06-01

Full Text Available This essay argues for the importance of an intersubjective and impure film theory in which the signal and the signaletic is considered as figures for approaching film. This in order to make the argument that the signaletic mode indeed enables a novel perspective on moving image history. The aesthetics of the signaletic has thus a history preceding that of electronic media, in particular when it comes to animation and experimental film. When constructing such an archaeology, however, dichotomies into sign and signal should be avoided; otherwise, the complexity of many of the films is reduced. In order to illuminate the latter point, four films by Gunvor Nelson is analyzed (both analog and digital, showing not only how both sign and signal interact but also how the aesthetics of the signal and the signaletic material is not dependant on the electronic as such.
Income-related inequalities in diseases and health conditions over the business cycle.

Science.gov (United States)

Ásgeirsdóttir, Tinna Laufey; Jóhannsdóttir, Hildur Margrét

2017-12-01

How business cycles affect income-related distribution of diseases and health disorders is largely unknown. We examine how the prevalence of thirty diseases and health conditions is distributed across the income spectrum using survey data collected in Iceland in 2007, 2009 and 2012. Thus, we are able to take advantage of the unusually sharp changes in economic conditions in Iceland during the Great Recession initiated in 2008 and the partial recovery that had already taken place by 2012 to analyze how income-related health inequality changed across time periods that can be described as a boom, crisis and recovery. The concentration curve and the concentration index are calculated for each disease, both overall and by gender. In all cases, we find a considerable income-related health inequality favoring higher income individuals, with a slight increase over the study period. Between 2007 and 2009, our results indicate increased inequality for women but decreased inequality for men. Between 2009 and 2012 on the contrary, men's inequality increases but women's decreases. The overarching result is thus that the economic hardship of the crisis temporarily increased female income-related health inequality, but decreased that of men.
Hacer globalización desde Ecuador. El tercer espacio como utopía para el ecuatoriano en Timarán y Cuabú de Nelson Estupiñán Bass

Directory of Open Access Journals (Sweden)

Wilfried Mvondo

2016-07-01

Full Text Available Este ensayo estudia cómo Nelson Estupiñán Bass da cuenta de la dinámica de la creación del tercer espacio en Ecuador con relación a la utopía de progreso socioeconómico que esta arrastra. Contempla la articulación entre “tercer espacio” y “utopía”. Este trabajo, que se apoya en el enfoque sociocrítico, analiza el espacio en Timarán y Cuabú y las inscripciones ideológicas que en ello afloran. Culmina en los siguientes resultados: 1 el tercer espacio es un lugar de intereses y resistencia para el ecuatoriano;y 2 este espacio suscita cierta utopía de desarrollo en el ecuatoriano. This paper studies how Nelson Estupiñán Bass realizes the dynamics in the creation of the third space in Ecuador relative to the utopia of socio-economic progress dragged by the latter. The study focuses on the articulation of the “third space” and the “utopia”. As this work is based on the sociocritical approach, it analyses the space from Timarán y Cuabú and the ideologies that it outcrops. The study deals with the following findings: 1 the third space is a space of interests and resistance for the Ecuadorian and 2 that space create a utopia of development in the Ecuadorian.
Choice of speciality amongst first-year medical students in the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal

Science.gov (United States)

Naidu, Edwin; Naidu, Jesse

2013-01-01

Abstract Background Trends in career choice amongst medical graduates have considerable implications for the percentage of the workforce available for training. Objective To investigate and review factors affecting career choice by undergraduate first-year medical students. Method This was a cross-sectional study using a closed-ended, semi-structured survey instrument. Two hundred and four questionnaires were administered to all first-year medical students at the Nelson R. Mandela School of Medicine in the first term of the 2012 academic session. Results The questionnaire was completed by 167 out of 204 students (81.8% response rate). Most of the respondents were South Africans (91%) and blacks (72%), with a higher proportion of women to men (2:1). The majority (86%) intended to undertake their postgraduate training in surgical specialties (53%), general surgery (50%) and cardiology (46%). Few were interested in an academic career in basic sciences (27.6%), either because they were not interested in research and/or teaching (48%), not clinically-orientated (20%), or found it to be an unattractive choice (12.3%). The top perceived career-related factors favouring choice of speciality were personal interest and benefits to patients as many (83%) respondents still viewed the medical profession as having a bright future in South Africa. Conclusions Our study highlighted the fact that self and patient interests were strong determinants of speciality choices by the students and the role of parents and practice in rural areas were considered least as potential influencing factors. This would appear to be a good indicator that the healthcare sector may be boosted in the future by doctors who are wholeheartedly committed to the service of the communities with the greatest disease burden.
Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance Data Published Between April 1, 2016 and January 31, 2017 - United States.

Science.gov (United States)

Thomas, Kimberly; Jajosky, Ruth; Coates, Ralph J; Calvert, Geoffrey M; Dewey-Mattia, Daniel; Raymond, Jaime; Singh, Simple D

2017-08-11

The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance Data Published Between April 1, 2016 and January 31, 2017 - United States, herein referred to as the Summary (Noninfectious), contains official statistics for nationally notifiable noninfectious conditions and disease outbreaks. This Summary (Noninfectious) is being published in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases and Conditions (1). Data on notifiable noninfectious conditions and disease outbreaks from prior years have been published previously (2,3).
The Nelson Mandela Children's Hospital

African Journals Online (AJOL)

Paediatric and neonatal surgery: Complex surgery for both congenital and acquired conditions will be centralised at NMCH, again taking advantage of the theatre and ICU facilities. • Neurology and neurosurgery: Video telemetry and other specialised neurological services will be developed. Complex neurosurgery will be ...
Environmental isotopes in New Zealand hydrology ; 4. Oxygen isotope variations in subsurface waters of the Waimea Plains, Nelson

International Nuclear Information System (INIS)

Stewart, M.K.; Dicker, M.J.I.; Johnston, M.R.

1981-01-01

Oxygen isotope measurements of ground and surface waters of the Waimea Plains, Nelson, have been used to identify sources of water in aquifers beneath the plains. Major rivers flowing onto the plains are from higher-altitude catchments (maximum altitude 2000 m) and have delta O 18 approximately equal to -7.2%, whereas rainfall on the plains and adjacent low-altitude catchment streams have delta O 18 approximately equal to -6.2%. The delta O 18 measurements indicate that the 3 major aquifer units, the ''Lower Confined Aquifers'' and the ''Upper Confined Aquifers'' in the Hope Gravel (Late Pleistocene) and the ''Unconfined Aquifers'' in the Appleby Gravel (Holocene) are recharged from different sources. The ''Lower Confined Aquifers'' probably receive slow recharge in the south near Brightwater. The ''Upper Confined Aquifers'' are recharged, in the south, from the Wairoa River and locally in the north are connected with the unconfined aquifers. The ''Unconfined Aquifers'' are recharged from the Waimea River and, away from the river, from rainfall. Intermixing of water, via multiple screened wells, between the various aquifers is also indicated. (author). 5 refs., 5 figs., 1 tab
A RETROSPECTIVE ANALYSIS OF ACUTE APPENDICITIS, RUPTURED APPENDICITIS AND THE LEVEL OF LEUKOCYTOSIS IN PAEDIATRIC SURGICAL PATIENTS OF NELSON MANDELA CENTRAL HOSPITAL.

Science.gov (United States)

Mtimba, L; Dhaffala, A; Molaoa, S Z

2017-06-01

Appendicectomy is the most commonly performed operation worldwide. The diagnosis is predominantly based on clinical findings. Some patients will clinically be unclear if ruptured or acute inflamed appendicitis; the level of white cell count has been used as the predictor for ruptured appendicitis. This was a retrospective chart review of paediatric surgical patients admitted at Nelson Mandela Central Hospital, Mthatha South Africa. A total of 214 patients with a diagnosis of acute appendicitis. Overall, the ruptured appendicitis was 62% and 38% were inflamed appendicitis. Nature of the acute appendicitis: White cell count, Inflamed, Ruptured, Total p-value 30 0 4 4. This study has demonstrated that in patients who are diagnosed with acute appendicitis clinically, the normal white cell count does not necessarily rule out ruptured acute appendicitis. But the risks of ruptured acute appendicitis increase with the increase level of white cell count.
The effects of time of disease occurrence, milk yield, and body condition on fertility of dairy cows.

Science.gov (United States)

Loeffler, S H; de Vries, M J; Schukken, Y H

1999-12-01

The associations between occurrence of diseases, milk yield, and body condition score on conception risk after first artificial insemination (AI) were analyzed in an observational study on a convenience sample of 43 farms participating in a herd health program. Data were taken from 9369 lactations, from 4382 cows inseminated between 20 and 180 d in milk from 1990 to 1996. Two logistic regression models, one containing data from all lactations and a subset containing data from 1762 lactations with body condition scoring, were used to determine pregnancy risk at first AI. The effects of herd deviation in test-day milk yield, body condition score loss, and milk fat to protein ratio changes in early lactation were significant predictors of pregnancy risk, independent of disease; days in milk; farm; and seasonal factors. Three different methods of disease parameterization (incidence rates, binomial classes dependent on the interval in days since last occurrence with respect to AI, and a linear variable weighted for this interval) produced similar results. Metritis, cystic ovarian disease, lameness, and mastitis gave odds ratios for pregnancy risk ranging from 0.35 to 1.15, largely dependent on the interval in days from final disease occurrence to first AI. Displaced abomasum, milk fever, and retained fetal membranes resulted in odds ratios for pregnancy risk of 0.25, 0.85, and 0.55, respectively. These diseases showed little relationship between fertility and the number of days since last occurrence. Results of this study confirm the negative effects of milk yield, body score condition loss, and disease on dairy cow fertility. The effects of some diseases on first service conception were strongly dependent on the interval since last disease occurrence. This was especially valid for clinical mastitis, which has an extremely weak effect on conception if occurring prior to AI and is associated with > 50% reduction in pregnancy risk if occurring in the 3 wk directly after
Altered kinematics of arm swing in Parkinson's disease patients indicates declines in gait under dual-task conditions.

Science.gov (United States)

Baron, Elise I; Miller Koop, Mandy; Streicher, Matthew C; Rosenfeldt, Anson B; Alberts, Jay L

2018-03-01

Declines in simultaneous performance of a cognitive and motor task are present in Parkinson's disease due to compromised basal ganglia function related to information processing. The aim of this project was to determine if biomechanical measures of arm swing could be used as a marker of gait function under dual-task conditions in Parkinson's disease patients. Twenty-three patients with Parkinson's disease completed single and dual-task cognitive-motor tests while walking on a treadmill at a self-selected rate. Multiple cognitive domains were evaluated with five cognitive tests. Cognitive tests were completed in isolation (single-task) and simultaneously with gait (dual-task). Upper extremity biomechanical data were gathered using the Motek CAREN system. Primary outcomes characterizing arm swing were: path length, normalized jerk, coefficient of variation of arm swing time, and cognitive performance. Performance on the cognitive tasks were similar across single and dual-task conditions. However, biomechanical measures exhibited significant changes between single and dual-task conditions, with the greatest changes occurring in the most challenging conditions. Arm swing path length decreased significantly from single to dual-task, with the greatest decrease of 21.16%. Jerk, characterizing smoothness, increased significantly when moving from single to dual-task conditions. The simultaneous performance of a cognitive and gait task resulted in decrements in arm swing while cognitive performance was maintained. Arm swing outcomes provide a sensitive measure of declines in gait function in Parkinson's disease under dual-task conditions. The quantification of arm swing is a feasible approach to identifying and evaluating gait related declines under dual-task conditions. Copyright © 2017. Published by Elsevier Ltd.

Hormone Treatment Restores Bone Density for Young Women with Menopause-Like Condition (Primary Ovarian Insufficiency)

Science.gov (United States)

... NIGMS NIMH NIMHD NINDS NINR NLM CC CIT CSR FIC NCATS NCCIH OD About NIH Who We ... valid results as to whether testosterone replacement could benefit women with POI, Dr. Nelson said. “While hormone ...
IgG4-related disease: a systemic condition with characteristic microscopic features

DEFF Research Database (Denmark)

Detlefsen, Sönke

2013-01-01

that a significant proportion of the AIP patients had a variety of extrapancreatic fibroinflammatory lesions, and that AIP therefore was the pancreatic manifestation of a systemic disease. Among these extrapancreatic manifestations, the extrahepatic bile ducts, salivary glands, thyroid, lymph nodes......During the first decade of the 21st century, IgG4-related disease (IgG4-RD), a fibroinflammatory condition occurring at multiple sites of the body, has been newly recognized. As indicated by its name, elevation of IgG4 in the serum and tissue is a common denominator of IgG4-RD. Since...... diseases on their own, others have been included under the umbrella of "multifocal fibrosclerosis". Biopsies or resection specimens from affected organs in IgG4-RD reveal several common microscopic features irrespective of the site of the lesion. Cellular and storiform fibrosis, lymphoplasmacytic...
Long-term follow-up of low-dose external pituitary irradiation for Cushing's disease

International Nuclear Information System (INIS)

Littley, M.D.; Shalet, S.M.; Beardwell, C.G.; Ahmed, S.R.; Sutton, M.L.

1990-01-01

Twenty-four patients (three male) with Cushing's disease, aged between 11 and 67 years, were treated with low-dose external pituitary irradiation (20 Gy in eight fractions over 10-12 days) and followed for between 13 and 171 months (median 93 months). Eleven patients (46%) went into remission 4-36 months after irradiation, but five subsequently relapsed. In this series, the low incidence of radiation-induced hypopituitarism and absence of other complications attributable to radiotherapy suggest that low-dose pituitary irradiation may be a useful treatment option in selected patients. However, long-term follow-up has demonstrated a high relapse rate and failure to prevent Nelson's syndrome in adrenalectomized patients, indicating that it should not be used as primary treatment in preference to selective adenomectomy. (author)
neuromuscular disease mimicking myasthenia gravis in a nigerian

African Journals Online (AJOL)

cardiomyopathy, may occur3,4 and cardiac and respiratory involvement have been documented as indices of worse ... The heart is not involved in myasthenia gravis and electrocardiographic findings remain normal .... transmission and of Motor neurons. In: Berhman. RE, Kliegman RM, Jenson HB eds. Nelson extbook of ...
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?

Science.gov (United States)

Hanson, M. A.; Gluckman, P. D.

2014-01-01

Extensive experimental animal studies and epidemiological observations have shown that environmental influences during early development affect the risk of later pathophysiological processes associated with chronic, especially noncommunicable, disease (NCD). This field is recognized as the developmental origins of health and disease (DOHaD). We discuss the extent to which DOHaD represents the result of the physiological processes of developmental plasticity, which may have potential adverse consequences in terms of NCD risk later, or whether it is the manifestation of pathophysiological processes acting in early life but only becoming apparent as disease later. We argue that the evidence suggests the former, through the operation of conditioning processes induced across the normal range of developmental environments, and we summarize current knowledge of the physiological processes involved. The adaptive pathway to later risk accords with current concepts in evolutionary developmental biology, especially those concerning parental effects. Outside the normal range, effects on development can result in nonadaptive processes, and we review their underlying mechanisms and consequences. New concepts concerning the underlying epigenetic and other mechanisms involved in both disruptive and nondisruptive pathways to disease are reviewed, including the evidence for transgenerational passage of risk from both maternal and paternal lines. These concepts have wider implications for understanding the causes and possible prevention of NCDs such as type 2 diabetes and cardiovascular disease, for broader social policy and for the increasing attention paid in public health to the lifecourse approach to NCD prevention. PMID:25287859
Tremor frequency characteristics in Parkinson's disease under resting-state and stress-state conditions.

Science.gov (United States)

Lee, Hong Ji; Lee, Woong Woo; Kim, Sang Kyong; Park, Hyeyoung; Jeon, Hyo Seon; Kim, Han Byul; Jeon, Beom S; Park, Kwang Suk

2016-03-15

Tremor characteristics-amplitude and frequency components-are primary quantitative clinical factors for diagnosis and monitoring of tremors. Few studies have investigated how different patient's conditions affect tremor frequency characteristics in Parkinson's disease (PD). Here, we analyzed tremor characteristics under resting-state and stress-state conditions. Tremor was recorded using an accelerometer on the finger, under resting-state and stress-state (calculation task) conditions, during rest tremor and postural tremor. The changes of peak power, peak frequency, mean frequency, and distribution of power spectral density (PSD) of tremor were evaluated across conditions. Patients whose tremors were considered more than "mild" were selected, for both rest (n=67) and postural (n=25) tremor. Stress resulted in both greater peak powers and higher peak frequencies for rest tremor (pstate condition. The distributions of PSD of tremor were symmetrical, regardless of conditions. Tremor is more evident and typical tremor characteristics, namely a lower frequency as amplitude increases, are different in stressful condition. Patient's conditions directly affect neural oscillations related to tremor frequencies. Therefore, tremor characteristics in PD should be systematically standardized across patient's conditions such as attention and stress levels. Copyright © 2016. Published by Elsevier B.V.
Miscellaneous conditions

International Nuclear Information System (INIS)

Berquist, T.H.; Hoffman, A.D.

1989-01-01

This paper reports on numerous conditions (systemic diseases, metabolic diseases, etc.) that may also affect the foot and ankle. In many cases, imaging of the foot and ankle is not performed for primary diagnostic purposes. However, radiographic changes do occur with these conditions. Therefore, it is important to be aware of radiographic abnormalities that these diseases may cause in the foot and ankle
The Construction of Liberal Democracy: The Role of Civil-Military Institutions in State and Nation-Building in West Germany and South Africa

Science.gov (United States)

2010-04-01

elections were held for the first time in April 1994. Nelson Mandela was elected president, ushering in a new era in South African politics. Although...between races.28 These lamentable conditions were what awaited Nelson Mandela and his Government of National Unity (GNU) when he took the presidential...oath on May 10, 1994. In addition to improving the living standards of the majority of South Africans, the Mandela government also had to address the
INFLUENCE OF WORKING CONDITIONS ON THE OCCURRENCE AND PREVALENCE OF DISEASES MUSCULOSKELETAL SYSTEM OF THE WORKERS OF LLC "TOLYATTI TRANSFORMER"

Directory of Open Access Journals (Sweden)

E. V. Semina

2013-01-01

Full Text Available The influence of working conditions upon the occurrence and (or prevalence of the musculoskeletal system diseases according to the results of the periodical medical examinations of Co. ltd. “TOGLIATTY TRANSFORMATOR” workers is analyzed. The direct influence of work conditions upon the occurrence and (or prevalence of the musculoskeletal system diseases in view of the prevalence of the foregoing diseases among different professions and working processes factors irrespective of age, sex and seniority is shown. Exciting causes of musculoskeletal system diseases are not only overwork due to hard manual labor, but also prolonged stay in a forced position.
Sedimentary Records of Hyperpycnal Flows and the Influence of River Damming on Sediment Dynamics of Estuaries: Examples from the Nelson, Churchill, Moisie and Sainte-Marguerite Rivers (Canada)

Science.gov (United States)

St-Onge, G.; Duboc, Q.; Boyer-Villemaire, U.; Lajeunesse, P.; Bernatchez, P.

2015-12-01

Sediment cores were sampled in the estuary of the Nelson and Churchill Rivers in western Hudson Bay, as well as in the estuary of the Moisie and Sainte-Marguerite Rivers in Gulf of St. Lawrence in order to evaluate the impact of hydroelectric dams on the sedimentary regime of these estuaries. The gravity cores at the mouth of the Nelson River recorded several cm-thick rapidly deposited layers with a reverse to normal grading sequence, indicating the occurrence of hyperpycnal flows generated by major floods during the last few centuries. These hyperpycnal flows were probably caused by ice-jam formation, which can increase both the flow and the sediment concentration following the breaching of such natural dams. Following the construction of hydroelectric dams since the 1960s, the regulation of river discharge prevented the formation of hyperpycnal flows, and hence the deposition of hyperpycnites in the upper part of the cores. In the core sampled in the estuary of the Churchill River, only one hyperpycnite was recorded. This lower frequency may be due to the enclosed estuary of the Churchill River, its weaker discharge and the more distal location of the coring site.In the Gulf of St. Lawrence, grain size measurements allowed the identification of a major flood around AD 1844±4 years in box cores from both the Sainte-Marguerite and Moisie Rivers, whereas a drastic decrease in variations in the median grain size occurred around AD ~1900 in the estuary of the Sainte-Marguerite River, highlighting the offshore impact of the SM1 dam construction in the early 1900s. Furthermore, sedimentological variations in the box cores from both estuaries have been investigated by wavelet analysis and the sharp disappearance of high frequencies around AD 1900 in the estuary of the dammed river (Sainte-Marguerite River), but not in the estuary of the natural river (Moisie River), also provides evidence of the influence of dams on the sedimentary regime of estuaries.
42 CFR 413.210 - Conditions for payment under the end-stage renal disease (ESRD) prospective payment system.

Science.gov (United States)

2010-10-01

... disease (ESRD) prospective payment system. 413.210 Section 413.210 Public Health CENTERS FOR MEDICARE... § 413.210 Conditions for payment under the end-stage renal disease (ESRD) prospective payment system... prospective payment system described in § 413.215 through § 413.235 of this part. (a) Qualifications for...
NELSON WERNECK SODRÉ: UM HISTORIADOR MILITAR DE ESQUERDA NO LIMIAR DA RENOVAÇÃO CRÍTICA DA GEOGRAFIA

Directory of Open Access Journals (Sweden)

Marco Túlio Martins

2011-12-01

Full Text Available Este artigo tem como proposta central a produção de Nelson Werneck Sodré titulada Introdução à Geografia: Geografia e Ideologia e a sua inserção na década de 1970 para o processo de renovação crítico da Geografia. Esta obra propicia a leitura do cenário em que a ciência geográfica se encontrava. Esta produção werneckiana aparece com um caráter denunciativo de como a Geografia estava sendo usada, não só no campo da ciência como também do próprio Estado brasileiro da época, para legitimar processos econômicos, sociais e, sobretudo, geopolíticos. Assim, pode ser considerada uma Introdução à Geografia às avessas, pois, esta não se restringe à análise de caráter inicial para entender a Geografia. A reflexão é construída por meio do resgate biográfico do autor, de sua obra e o contexto histórico no qual foi produzida. Resgatar-se-á não somente um período da história da Geografia, mas, algo que é mais amplo: o pensamento geográfico.
Common and Uncommon Conditions of Breast Disease in Children and Adolescents: A Pictorial Review

Energy Technology Data Exchange (ETDEWEB)

Cho, Hyoun; Kim, Kyu Soon; Kim, Da Mi [Dept. of f Radiology, Eulji University Hospital, Daejeon (Korea, Republic of); Kim, You Me [Dept. of Radiology, Dankook University Hospital, Cheonan (Korea, Republic of); Kim, Hak Hee [Dept. of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

2013-02-15

The purpose of this study is to review various breast diseases in children and adolescents and to illustrate the sonographic findings. We reviewed the cases at our institution in order to identify breast disease in children and adolescent patients who underwent sonography and mammography. Breast disease in children and adolescents included developmental disturbance, infection, benign tumors and inherent defects. In contrast to adults, the radiologic findings of malignant breast conditions in pediatric populations have rarely been reported; however, we show ductal carcinoma in situ with juvenile fibroadenoma and rhabdomyosarcoma. During childhood and adolescence, the recognition and correct identification of physiologic breast development and specific lesions in breast entities on radiologic findings is most helpful in identifying and characterizing abnormalities and in guiding further investigation.
Extending Injury- and Disease-Resistant CNS Phenotypes by Repetitive Epigenetic Conditioning

Directory of Open Access Journals (Sweden)

Jeffrey M. Gidday

2015-03-01

Full Text Available Significant reductions in the extent of acute injury in the CNS can be achieved by exposure to different preconditioning stimuli, but the duration of the induced protective phenotype is typically short-lasting, and thus is deemed as limiting its clinical applicability. Extending the period over which such adaptive epigenetic changes persist – in effect, expanding conditioning’s therapeutic window – would significantly broaden the potential applications of such a treatment approach in patients. The frequency of the conditioning stimulus may hold the key. While transient (1-3 days protection against CNS ischemic injury is well established preclinically following a single preconditioning stimulus, repetitively presenting preconditioning stimuli extends the duration of ischemic tolerance by many weeks. Moreover, repetitive intermittent postconditioning enhances postischemic recovery metrics and improves long-term survival. Intermittent conditioning is also efficacious for preventing or delaying injury in preclinical models of chronic neurodegenerative disease, and for promoting long-lasting functional improvements in a number of other pathologies as well. Although the detailed mechanisms underlying these protracted kinds of neuroplasticity remain largely unstudied, accumulating empirical evidence supports the contention that all of these adaptive phenotypes are epigenetically mediated. Going forward, additional preclinical demonstrations of the ability to induce sustained beneficial phenotypes that reduce the burden of acute and chronic neurodegeneration, and experimental interrogations of the regulatory constructs responsible for these epigenetic responses, will accelerate the identification of not only efficacious, but practical, adaptive epigenetics-based treatments for individuals with neurological disease.
Alpha-amidated peptides derived from pro-opiomelanocortin in human pituitary tumours

DEFF Research Database (Denmark)

Fenger, M; Johnsen, A H

1988-01-01

Human pituitary tumours, obtained at surgery for Cushing's disease and Nelson's syndrome, were extracted and the content and molecular forms of pro-opiomelanocortin (POMC)-derived peptides determined by radioimmunoassay, gel chromatography, reversed-phase high-performance liquid chromatography....... In conclusion, all the molecular forms of the amidated peptides detected in tumours from patients with Cushing's disease and Nelson's syndrome were similar to the molecular forms found in the normal human pituitary. The main difference between the tumours and the normal pituitary was the greater amount...... (HPLC) and sequence analysis. In the tumours from patients with Cushing's disease the mean concentrations of amidated peptides relative to the total amount of POMC were as follows: alpha-MSH, 1.7%; amidated gamma-MSH (gamma 1-MSH), 8.5% and the peptide linking gamma-MSH and ACTH in the precursor (hinge...
Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa.

Science.gov (United States)

van Huyssteen, Mea; Milne, Pieter J; Campbell, Eileen E; van de Venter, Maryna

2011-01-01

Diabetes mellitus is a growing problem in South Africa and of concern to traditional African health practitioners in the Nelson Mandela Metropole, because they experience a high incidence of diabetic cases in their practices. A collaborative research project with these practitioners focused on the screening of Bulbine frutescens, Ornithogalum longibracteatum, Ruta graveolens, Tarchonanthus camphoratus and Tulbaghia violacea for antidiabetic and cytotoxic potential. In vitro glucose utilisation assays with Chang liver cells and C2C12 muscle cells, and growth inhibition assays with Chang liver cells were conducted. The aqueous extracts of Bulbine frutescens (143.5%), Ornithogalum longibracteatum (131.9%) and Tarchonanthus camphoratus (131.5%) showed significant increased glucose utilisation activity in Chang liver cells. The ethanol extracts of Ruta graveolens (136.9%) and Tulbaghia violacea (140.5%) produced the highest increase in glucose utilisation in C2C12 muscle cells. The ethanol extract of Bulbine frutescens produced the most pronounced growth inhibition (33.3%) on Chang liver cells. These findings highlight the potential for the use of traditional remedies in the future for the management of diabetes and it is recommended that combinations of these plants be tested in future.
Beware of Ticks (A Cup of Health with CDC)

Centers for Disease Control (CDC) Podcasts

2015-05-14

Lyme disease is an infection caused by a bacteria that is transmitted by the bites of infected blacklegged ticks. In this podcast, Dr. Christina Nelson discusses ways to help prevent Lyme disease. Created: 5/14/2015 by MMWR. Date Released: 5/14/2015.
Turbulent dispersivity under conditions relevant to airborne disease transmission between laboratory animals

Science.gov (United States)

Halloran, Siobhan; Ristenpart, William

2013-11-01

Virologists and other researchers who test pathogens for airborne disease transmissibility often place a test animal downstream from an inoculated animal and later determine whether the test animal became infected. Despite the crucial role of the airflow in pathogen transmission between the animals, to date the infectious disease community has paid little attention to the effect of airspeed or turbulent intensity on the probability of transmission. Here we present measurements of the turbulent dispersivity under conditions relevant to experimental tests of airborne disease transmissibility between laboratory animals. We used time lapse photography to visualize the downstream transport and turbulent dispersion of smoke particulates released from a point source downstream of an axial fan, thus mimicking the release and transport of expiratory aerosols exhaled by an inoculated animal. We show that for fan-generated turbulence the plume width is invariant with the mean airspeed and, close to the point source, increases linearly with downstream position. Importantly, the turbulent dispersivity is insensitive to the presence of meshes placed downstream from the point source, indicating that the fan length scale dictates the turbulent intensity and corresponding dispersivity.
An Outflow Boundary Condition Model for Noninvasive Prediction of Fractional Flow Reserve in Diseased Coronary Arteries.

Science.gov (United States)

Fayssal, Iyad A; Moukalled, Fadl; Alam, Samir; Isma'eel, Hussain

2018-04-01

This paper reports on a new boundary condition formulation to model the total coronary myocardial flow and resistance characteristics of the myocardial vascular bed for any specific patient when considered for noninvasive diagnosis of ischemia. The developed boundary condition model gives an implicit representation of the downstream truncated coronary bed. Further, it is based on incorporating patient-specific physiological parameters that can be noninvasively extracted to account for blood flow demand to the myocardium at rest and hyperemic conditions. The model is coupled to a steady three-dimensional (3D) collocated pressure-based finite volume flow solver and used to characterize the "functional significance" of a patient diseased coronary artery segment without the need for predicting the hemodynamics of the entire arterial system. Predictions generated with this boundary condition provide a deep understanding of the inherent challenges behind noninvasive image-based diagnostic techniques when applied to human diseased coronary arteries. The overall numerical method and formulated boundary condition model are validated via two computational-based procedures and benchmarked with available measured data. The newly developed boundary condition is used via a designed computational methodology to (a) confirm the need for incorporating patient-specific physiological parameters when modeling the downstream coronary resistance, (b) explain the discrepancies presented in the literature between measured and computed fractional flow reserve (FFRCT), and (c) discuss the current limitations and future challenges in shifting to noninvasive assessment of ischemia.
The resistance response of sunflower genotypes to black stem disease under controlled conditions

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Reza DARVISHZADEH

2010-09-01

Full Text Available Phoma black stem, caused by Phoma macdonaldii, is one of the most important diseases of sunflower in the world. The sources of resistance to Phoma black stem were investigated. A total of 184 genotypes, including some recombinant inbred lines (RILs, several M6 mutant lines obtained by gamma irradiation of seed of the genotype AS 613, and other genotypes from different countries, were evaluated against an aggressive French isolate (MP6 in controlled conditions. The study was carried out in a randomized complete block design with three replicates. Each replicate consisted of 10–12 seedlings. Twenty μL of spore suspension (106 pycnidiospores mL-1 were deposited on the intersection of the cotyledon petiole and the hypocotyl of sunflower plantlets at the two-leaf stage. The percentage of the area exhibiting disease symptoms was scored on the two cotyledon petioles of each of the plantlets three, five and seven days after inoculation. The disease progress rate (rd, as the slope of the regression line for disease severity against time, was also calculated. Analysis of variance detected significant differences among sunflower genotypes for disease severity 7 days after inoculation,as well as for the disease progress rate. A strong correlation (r=0.96, P<0.01 was found between disease severity 7 days after inoculation and the disease progress rate. The inbred lines F1250/03 (origin: Hungary, M5-54-1, M6-862-1 (mutant lines, SDR 18 (origin: USA and two wild Helianthus accessions, 1012 Nebraska and 211 Illinois, (wild type were highly resistant to Phoma black stem. These findings will assist breeders in choosing parent plants for breeding durable resistance to Phoma black stem.

Genetic parameters for energy balance, fat /protein ratio, body condition score and disease traits in German Holstein cows.

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Buttchereit, N; Stamer, E; Junge, W; Thaller, G

2012-08-01

Various health problems in dairy cows have been related to the magnitude and duration of the energy deficit post partum. Energy balance indicator traits like fat/protein ratio in milk and body condition score could be used in selection programmes to help predicting breeding values for health traits, but currently there is a lack of appropriate genetic parameters. Therefore, genetic correlations among energy balance, fat/protein ratio, and body condition score, and mastitis, claw and leg diseases, and metabolic disorders were estimated using linear and threshold models on data from 1693 primiparous cows recorded within the first 180 days in milk. Average daily energy balance, milk fat/protein ratio and body condition score were 8 MJ NEL, 1.13 and 2.94, respectively. Disease frequencies (% cows with at least one case) were 24.6% for mastitis, 9.7% for metabolic disorders and 28.2% for claw and leg diseases. Heritability estimates were 0.06, 0.30 and 0.34 for energy balance, fat/protein ratio and body condition score, respectively. For the disease traits, heritabilities ranged between 0.04 and 0.15. The genetic correlations were, in general, associated with large standard errors, but, although not significant, the results suggest that an improvement of overall health can be expected if energy balance traits are included into future breeding programmes. A low fat/protein ratio might serve as an indicator for metabolic stability and health of claw and legs. Between body condition and mastitis, a significant negative correlation of -0.40 was estimated. The study provides a new insight into the role energy balance traits can play as auxiliary traits for robustness of dairy cows. It was concluded that both, fat/protein ratio and body condition score, are potential variables to describe how well cows can adapt to the challenge of early lactation. However, the genetic parameters should be re-estimated on a more comprehensive data set. © 2011 Blackwell Verlag GmbH.
The impact of adjusted work conditions and disease-modifying drugs on work ability in multiple sclerosis.

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Wickström, Anne; Fagerström, Maria; Wickström, Lucas; Granåsen, Gabriel; Dahle, Charlotte; Vrethem, Magnus; Sundström, Peter

2017-07-01

Multiple sclerosis (MS) is a neurological disorder that causes significantly reduced ability to work, and the Expanded Disability Status Scale (EDSS) is one of the main predictors for reduced work ability. To investigate how work requirements, flexible work conditions and disease-modifying drugs (DMDs) influence the work ability in relation to different EDSS grades in two MS populations. Work ability was studied in two MS populations: one in the southern and one in the northern part of Sweden, both demographically similar. In the latter population, more active work-promoting interventions have been practised and second-generation DMDs have been widely used from the onset of disease for several years. The proportion of MS patients who participated in the workforce or studied was significantly higher in the northern compared with the southern population ( p work conditions and were able to work more hours per week. Higher EDSS was associated with lower reduction in number of worked hours per week in the northern population ( p = 0.042). Our data indicated that treatment strategy and adjusted work conditions have impact on work ability in MS.
Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases

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Rakesh Kumar

2017-12-01

Full Text Available The importance of horse (Equus caballus to equine practitioners and researchers cannot be ignored. An unevenly distributed population of equids harbors numerous diseases, which can affect horses of any age and breed. Among these, the affections of nervous system are potent reason for death and euthanasia in equids. Many episodes associated with the emergence of equine encephalitic conditions have also pose a threat to human population as well, which signifies their pathogenic zoonotic potential. Intensification of most of the arboviruses is associated with sophisticated interaction between vectors and hosts, which supports their transmission. The alphaviruses, bunyaviruses, and flaviviruses are the major implicated groups of viruses involved with equines/humans epizootic/epidemic. In recent years, many outbreaks of deadly zoonotic diseases such as Nipah virus, Hendra virus, and Japanese encephalitis in many parts of the globe addresses their alarming significance. The equine encephalitic viruses differ in their global distribution, transmission and main vector species involved, as discussed in this article. The current review summarizes the status, pathogenesis, pathology, and impact of equine neuro-invasive conditions of viral origin. A greater understanding of these aspects might be able to provide development of advances in neuro-protective strategies in equine population.
Discovery of temporal and disease association patterns in condition-specific hospital utilization rates.

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Julian S Haimovich

Full Text Available Identifying temporal variation in hospitalization rates may provide insights about disease patterns and thereby inform research, policy, and clinical care. However, the majority of medical conditions have not been studied for their potential seasonal variation. The objective of this study was to apply a data-driven approach to characterize temporal variation in condition-specific hospitalizations. Using a dataset of 34 million inpatient discharges gathered from hospitals in New York State from 2008-2011, we grouped all discharges into 263 clinical conditions based on the principal discharge diagnosis using Clinical Classification Software in order to mitigate the limitation that administrative claims data reflect clinical conditions to varying specificity. After applying Seasonal-Trend Decomposition by LOESS, we estimated the periodicity of the seasonal component using spectral analysis and applied harmonic regression to calculate the amplitude and phase of the condition's seasonal utilization pattern. We also introduced four new indices of temporal variation: mean oscillation width, seasonal coefficient, trend coefficient, and linearity of the trend. Finally, K-means clustering was used to group conditions across these four indices to identify common temporal variation patterns. Of all 263 clinical conditions considered, 164 demonstrated statistically significant seasonality. Notably, we identified conditions for which seasonal variation has not been previously described such as ovarian cancer, tuberculosis, and schizophrenia. Clustering analysis yielded three distinct groups of conditions based on multiple measures of seasonal variation. Our study was limited to New York State and results may not directly apply to other regions with distinct climates and health burden. A substantial proportion of medical conditions, larger than previously described, exhibit seasonal variation in hospital utilization. Moreover, the application of clustering
Combined heat and gamma-irradiation treatments for the control of strawberry diseases under market conditions

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Brodrick, H.T.; Thomas, A.C.; Van Tonder, A.J.; Terblanche, J.C.

1977-02-01

The spoilage of strawberries under local market conditions was investigated. It was confirmed that the major losses are due to 'leak' disease caused by Rhizopus stolonifer (Ehr. ex Fr.) Lind. It was also established that further fruit losses in summer are due to anthracnose caused by the fungus Colletotrichum acutatum Simmonds. This is the first time that the latter pathogen has been isolated and identified and recognised as a problem on strawberries in South Africa. Studies with R. stolonifer in culture showed that 46 degrees Celsius for 20 min (the previous international standard heat treatment for fruit) was disappointing, while a treatment at 50 degrees Celsius for 10 min effectively inhibited spore germination. Irradiation studies with cultures of R. stolonifer and C. acutatum showed that a dose of 200 and 100 krad, respectively, resulted in excellent inhibition of spore germination. However, irradiating in nitrogen gas resulted in a tenfold reduction in the effectiveness of the irradiation treatments. The use of nitrogen during irradiation, therefore, cannot be considered, especially where an effective control of the fungal pathogens is desired. Investigations with different cultivars clearly demonstrated the synergistic effect on disease control obtained when combining heat and irradiation treatments. The combination treatment (moist heat at 50-52 degrees Celsius for 10 min plus 200 krad), besides effectively controlling both diseases in strawberries, did not adversely affect berry quality. In simulated transport tests it was shown that a minimal amount of berry softening did occur with this treatment, but this adverse effect was negligible compared with the beneficial effect obtained from disease control. In semi-commercial experiments it was shown that the combination heat and irradiation treatment effectively controlled spoilage diseases for a period of several days from picking, thus allowing sufficient time to market the fruit under local market
Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales

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Burwinkle Tasha M

2007-07-01

Full Text Available Abstract Background Advances in biomedical science and technology have resulted in dramatic improvements in the healthcare of pediatric chronic conditions. With enhanced survival, health-related quality of life (HRQOL issues have become more salient. The objectives of this study were to compare generic HRQOL across ten chronic disease clusters and 33 disease categories/severities from the perspectives of patients and parents. Comparisons were also benchmarked with healthy children data. Methods The analyses were based on over 2,500 pediatric patients from 10 physician-diagnosed disease clusters and 33 disease categories/severities and over 9,500 healthy children utilizing the PedsQL™ 4.0 Generic Core Scales. Patients were recruited from general pediatric clinics, subspecialty clinics, and hospitals. Results Pediatric patients with diabetes, gastrointestinal conditions, cardiac conditions, asthma, obesity, end stage renal disease, psychiatric disorders, cancer, rheumatologic conditions, and cerebral palsy self-reported progressively more impaired overall HRQOL than healthy children, respectively, with medium to large effect sizes. Patients with cerebral palsy self-reported the most impaired HRQOL, while patients with diabetes self-reported the best HRQOL. Parent proxy-reports generally paralleled patient self-report, with several notable differences. Conclusion The results demonstrate differential effects of pediatric chronic conditions on patient HRQOL across diseases clusters, categories, and severities utilizing the PedsQL™ 4.0 Generic Core Scales from the perspectives of pediatric patients and parents. The data contained within this study represents a larger and more diverse population of pediatric patients with chronic conditions than previously reported in the extant literature. The findings contribute important information on the differential effects of pediatric chronic conditions on generic HRQOL from the perspectives of children and
Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL 4.0 Generic Core Scales.

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Varni, James W; Limbers, Christine A; Burwinkle, Tasha M

2007-07-16

Advances in biomedical science and technology have resulted in dramatic improvements in the healthcare of pediatric chronic conditions. With enhanced survival, health-related quality of life (HRQOL) issues have become more salient. The objectives of this study were to compare generic HRQOL across ten chronic disease clusters and 33 disease categories/severities from the perspectives of patients and parents. Comparisons were also benchmarked with healthy children data. The analyses were based on over 2,500 pediatric patients from 10 physician-diagnosed disease clusters and 33 disease categories/severities and over 9,500 healthy children utilizing the PedsQL 4.0 Generic Core Scales. Patients were recruited from general pediatric clinics, subspecialty clinics, and hospitals. Pediatric patients with diabetes, gastrointestinal conditions, cardiac conditions, asthma, obesity, end stage renal disease, psychiatric disorders, cancer, rheumatologic conditions, and cerebral palsy self-reported progressively more impaired overall HRQOL than healthy children, respectively, with medium to large effect sizes. Patients with cerebral palsy self-reported the most impaired HRQOL, while patients with diabetes self-reported the best HRQOL. Parent proxy-reports generally paralleled patient self-report, with several notable differences. The results demonstrate differential effects of pediatric chronic conditions on patient HRQOL across diseases clusters, categories, and severities utilizing the PedsQL 4.0 Generic Core Scales from the perspectives of pediatric patients and parents. The data contained within this study represents a larger and more diverse population of pediatric patients with chronic conditions than previously reported in the extant literature. The findings contribute important information on the differential effects of pediatric chronic conditions on generic HRQOL from the perspectives of children and parents utilizing the PedsQL 4.0 Generic Core Scales. These findings
Systematic mapping review about costs and economic evaluations of skin conditions and diseases in the aged.

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Lichterfeld-Kottner, Andrea; Hahnel, Elisabeth; Blume-Peytavi, Ulrike; Kottner, Jan

2017-02-01

Skin conditions and dermatological diseases associated with advanced age (e.g. fungal infection, dry skin and itch) receive increasingly attention in clinical practice and research. Cost and economic evaluations are important sources to inform priority setting and ressource allocation decisions in healthcare. The economics of skin conditions in aged populations has not been systematically reviewed so far. The aim of this mapping review was to summarize the economic evidence of selected skin conditions in the aged (65 + years). A mapping literature review and evidence summary was conducted. Searches were conducted in data bases Medline and Embase via OVID. Cinahl was searched using EBSCO. References lists of potential eligible studies, reviews, guidelines or other sources were screened for additional literature. For evaluation of methodological quality of full economic analyses the Consensus on Health Economic Criteria (CHEC) checklist was used. Database searches resulted in 1388 records. A total of 270 articles were read in full-text. Thirty-five publications were finally included in the data analysis reporting 38 economic analyses. Ten cost of illness analyses and 26 cost-effectiveness analyses reporting about pressure ulcers, skin tears, pressure ulcers, incontinence associated dermatitis and intertrigo/contact dermatitis/candidiasis treatment and prevention and onychomycosis testing were identified. Limited evidence indicated that low air loss beds were more cost effective than standard beds for prevention of pressure ulcers. Standardized skin care regimens seem to lower the incidence of pressure ulcers, skin tears and IAD but a cost saving effect was not always observed. Findings of this mapping review indicate that there is a paucity of high quality evidence regarding the economic impact of age-associated skin conditions and diseases. Substantial heterogeneity in terms of study design, evaluation perspective, time period, and way of cost estimation was
Comorbid Conditions in Neonates With Congenital Heart Disease.

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Krishnamurthy, Ganga; Ratner, Veniamin; Bacha, Emile; Aspelund, Gudrun

2016-08-01

The objectives of this review are to discuss the pathophysiology, clinical impact and treatment of major noncardiac anomalies, and prematurity in infants with congenital heart disease. MEDLINE and PubMed. Mortality risk is significantly higher in patients with congenital heart disease and associated anomalies compared with those in whom the heart defect occurs in isolation. Although most noncardiac structural anomalies do not require surgery in the neonatal period, several require surgery for survival. Management of such infants poses multiple challenges. Premature infants with congenital heart disease face challenges imposed by their immature organ systems, which are susceptible to injury or altered function by congenital heart disease and abnormal circulatory physiology independent of congenital heart disease. For optimal outcomes in premature infants or in infants with multiple congenital anomalies, a collaborative interdisciplinary approach is necessary.
Aortic dissection: natural course of disease? Report of two cases representing the extremes of the condition

International Nuclear Information System (INIS)

Tollefsen, Isak; Joergensen, Ingrid K.; Woie, Leik; Fossdal, Jan E.

2001-01-01

Objective: In a time when diagnostic methods and above all, surgical as well as interventional radiological treatment for aortic aneurysms and aortic dissections have reached a point nobody could think of a few years back, the present authors feel that it is worth while to remind oneself of the natural course of disease in these conditions. Taking into consideration the high morbidity and mortality rate in surgically treated patients with aortic dissection, and the high complication rate per- and postoperatively, it also seems right to ask if a more expectative and conservative approach to the condition sometimes perhaps may be justified. Methods and material: Two case reports are given. One was a 15-year-old boy with Stanford (Daily) type B dissection who statistically ought to have a good prognosis, but who died within 2 h after onset of symptoms. The other patient, a middle-aged woman with Stanford type A dissection, survived for 25 years without operation. Conclusion: These two cases, though not unique viewed separately, we consider to represent the extremes of the condition and also a natural course of disease, while none of them was operated on
Aortic dissection: natural course of disease? Report of two cases representing the extremes of the condition.

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Tollefsen, I; Jørgensen, I K; Woie, L; Fossdal, J E

2001-10-01

In a time when diagnostic methods and above all, surgical as well as interventional radiological treatment for aortic aneurysms and aortic dissections have reached a point nobody could think of a few years back, the present authors feel that it is worth while to remind oneself of the natural course of disease in these conditions. Taking into consideration the high morbidity and mortality rate in surgically treated patients with aortic dissection, and the high complication rate per- and postoperatively, it also seems right to ask if a more expectative and conservative approach to the condition sometimes perhaps may be justified. Two case reports are given. One was a 15-year-old boy with Stanford (Daily) type B dissection who statistically ought to have a good prognosis, but who died within 2 h after onset of symptoms. The other patient, a middle-aged woman with Stanford type A dissection, survived for 25 years without operation. These two cases, though not unique viewed separately, we consider to represent the extremes of the condition and also a natural course of disease, while none of them was operated on.
Genetics Home Reference: pseudohypoaldosteronism type 2

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... Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan ... hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. ...
Foreign object - swallowed

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... Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 327. Pfau PR, Hancock SM. Foreign ... Gastrointestinal and Liver Disease . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 27. Schoem SR, Rosbe KW, ...
Dry eye disease and allergic conditions: A Korean nationwide population-based study.

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Kim, Minkyeong; Oh, Jong-Hyun; Park, Choul Yong; Lee, Sang Wha

2016-11-01

Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface. No epidemiologic reports have yet been published about the relationship between DED and allergic rhinitis or sensitization to allergens. To investigate the association between DED and allergic conditions in the general adult Korean population. This population-based cross-sectional study included 17,542 individuals (ages ≥ 19 years) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012. Data for total serum immunoglobulin E (IgE) and allergen-specific IgE levels were available for 1857 subjects. Data were analyzed by using logistic regression to determine the association of DED with allergy or allergic conditions, including allergic rhinitis, atopic dermatitis, asthma, increased total serum IgE, and sensitization to house-dust mite (Dermatophagoides farinae), dog, and cockroach allergens. The prevalence of DED, allergic rhinitis, atopic dermatitis, and asthma was 10.4, 13.1, 2.2, and 3.3%, respectively. The prevalence of the increased total serum IgE level and sensitization to D. farinae, dog, and cockroach allergens was 34.6, 15.7, 1.0, and 2.8%, respectively. After adjusting for general characteristics, DED was significantly associated with allergic rhinitis (odds ratio 1.58 [95% confidence interval, 1.38-1.81]) and D. farinae sensitization (odds ratio 1.80 [95% confidence interval, 1.17-2.79]). This study demonstrated a close association between DED and both allergic rhinitis and D. farinae sensitization in Korean adults. Further studies are warranted to establish temporal relationships between DED and allergic rhinitis.
An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition.

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Lang, Gernot; Liu, Yishan; Geries, Janna; Zhou, Zhiyu; Kubosch, David; Südkamp, Norbert; Richards, R Geoff; Alini, Mauro; Grad, Sibylle; Li, Zhen

2018-04-01

The aim of this study was to compare the effect of different disease initiators of degenerative disc disease (DDD) within an intervertebral disc (IVD) organ culture system and to understand the interplay between inflammation and degeneration in the early stage of DDD. Bovine caudal IVDs were cultured within a bioreactor for up to 11 days. Control group was cultured under physiological loading (0.02-0.2 MPa; 0.2 Hz; 2 hr/day) and high glucose (4.5 g/L) medium. Detrimental loading (0.32-0.5 MPa, 5 Hz; 2 hr/day) and low glucose (2 g/L) medium were applied to mimic the condition of abnormal mechanical stress and limited nutrition supply. Tumour necrosis factor alpha (TNF-α) was injected into the nucleus pulposus (100 ng per IVD) as a proinflammatory trigger. TNF-α combined with detrimental loading and low glucose medium up-regulated interleukin 1β (IL-1β), IL-6, and IL-8 gene expression in disc tissue, nitric oxide, and IL-8 release from IVD, which indicate a proinflammatory effect. The combined initiators up-regulated matrix metalloproteinase 1 gene expression, down-regulated gene expression of Type I collagen in annulus fibrosus and Type II collagen in nucleus pulposus, and reduced the cell viability. Furthermore, the combined initiators induced a degradative effect, as indicated by markedly higher glycosaminoglycan release into conditioned medium. The combination of detrimental dynamic loading, nutrient deficiency, and TNF-α intradiscal injection can synergistically simulate the proinflammatory and degenerative disease condition within DDD. This model will be of high interest to screen therapeutic agents in further preclinical studies for early intervention and treatment of DDD. Copyright © 2018 John Wiley & Sons, Ltd.
Proposed Industry Best Practices in Development and Marketing of Medical Foods for the Management of Chronic Conditions and Diseases while Awaiting Regulation.

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Burnett, Bruce; Levy, Robert M

Ideal therapeutics have low toxicity and can effectively manage condition(s) or disease(s). The Food & Drug Administration (FDA) marketing category of therapeutics called “medical foods” (MFs) meets such a definition. Medical foods have existed in Federal law since passage the Orphan Drug Act in 1988, which created a category of nutritional therapeutics separate from drugs. Unfortunately, MFs are not widely understood by the medical community or utilized in all patients who need them due to lack of a FDA-approval process, unclear and contradictory guidance especially with regard for need for an investigational new drug (IND) application, and no clear regulations regarding their development and marketing. The goals of this article are to propose “Best Practices” to guide the medical food industry in the development and marketing of products as well as to serve as a starting point for suggestions regarding further FDA regulation so that therapeutics which are shown to be generally recognized as safe (GRAS), provide food ingredients to meet a distinctive nutritional requirement for a specific condition/disease and are proven effective for the management for that condition/disease can be used to benefit patients who need them.
Dermatomycosis: Conditions that contribute to the disease development

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Stojanov Igor M.

2011-01-01

Full Text Available Skin lesions caused by dermatophytes are classified depending on the infected skin structure: surface layer of cutis, fur layer, clutches or nails. Surface mycoses are caused by dermatophytes: Epidermophyton, Microsporum and Trichophyton species (also important are Malassezia spp., Candida spp., and Trichosporon. Skin is the target tissue for fungal infections if the epithelial layer is damaged and immune system cannot cope with the infection, or if the conditions are favorable for dermatophytes, which spread in the cutis due to the enzyme activities. Dermatophytes can be found on skin surface if they contaminate or colonize epidermis or hair follicles. However, clinical symptoms of lesion on the skin are sometimes absent. According to the literature data 6-9% of skin lesions are caused by dermatophyte in human medicine. Similar situation is in veterinary medicine. Fungus that cause dermatomycosis are widespread in the nature and could be divided into: zoophilic, geophilic and anthrophilic. The goal of this paper is to present the latest knowledge in pathogenesis on dermatomycosis, predisposing factors important for the outcome of the disease, and immunological reaction of organism to the fungal infection. Our intention is to summarize the subject and present the facts related to specific problems in dermatomycosis.
Transcriptomic Analysis and the Expression of Disease-Resistant Genes in Oryza meyeriana under Native Condition.

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Bin He

Full Text Available Oryza meyeriana (O. meyeriana, with a GG genome type (2n = 24, accumulated plentiful excellent characteristics with respect to resistance to many diseases such as rice shade and blast, even immunity to bacterial blight. It is very important to know if the diseases-resistant genes exist and express in this wild rice under native conditions. However, limited genomic or transcriptomic data of O. meyeriana are currently available. In this study, we present the first comprehensive characterization of the O. meyeriana transcriptome using RNA-seq and obtained 185,323 contigs with an average length of 1,692 bp and an N50 of 2,391 bp. Through differential expression analysis, it was found that there were most tissue-specifically expressed genes in roots, and next to stems and leaves. By similarity search against protein databases, 146,450 had at least a significant alignment to existed gene models. Comparison with the Oryza sativa (japonica-type Nipponbare and indica-type 93-11 genomes revealed that 13% of the O. meyeriana contigs had not been detected in O. sativa. Many diseases-resistant genes, such as bacterial blight resistant, blast resistant, rust resistant, fusarium resistant, cyst nematode resistant and downy mildew gene, were mined from the transcriptomic database. There are two kinds of rice bacterial blight-resistant genes (Xa1 and Xa26 differentially or specifically expressed in O. meyeriana. The 4 Xa1 contigs were all only expressed in root, while three of Xa26 contigs have the highest expression level in leaves, two of Xa26 contigs have the highest expression profile in stems and one of Xa26 contigs was expressed dominantly in roots. The transcriptomic database of O. meyeriana has been constructed and many diseases-resistant genes were found to express under native condition, which provides a foundation for future discovery of a number of novel genes and provides a basis for studying the molecular mechanisms associated with disease
Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey

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Lorraine Johnson

2014-03-01

Full Text Available Overview. The Centers for Disease Control and Prevention (CDC health-related quality of life (HRQoL indicators are widely used in the general population to determine the burden of disease, identify health needs, and direct public health policy. These indicators also allow the burden of illness to be compared across different diseases. Although Lyme disease has recently been acknowledged as a major health threat in the USA with more than 300,000 new cases per year, no comprehensive assessment of the health burden of this tickborne disease is available. This study assesses the HRQoL of patients with chronic Lyme disease (CLD and compares the severity of CLD to other chronic conditions.Methods. Of 5,357 subjects who responded to an online survey, 3,090 were selected for the study. Respondents were characterized as having CLD if they were clinically diagnosed with Lyme disease and had persisting symptoms lasting more than 6 months following antibiotic treatment. HRQoL of CLD patients was assessed using the CDC 9-item metric. The HRQoL analysis for CLD was compared to published analyses for the general population and other chronic illnesses using standard statistical methods.Results. Compared to the general population and patients with other chronic diseases reviewed here, patients with CLD reported significantly lower health quality status, more bad mental and physical health days, a significant symptom disease burden, and greater activity limitations. They also reported impairment in their ability to work, increased utilization of healthcare services, and greater out of pocket medical costs.Conclusions. CLD patients have significantly impaired HRQoL and greater healthcare utilization compared to the general population and patients with other chronic diseases. The heavy burden of illness associated with CLD highlights the need for earlier diagnosis and innovative treatment approaches that may reduce the burden of illness and concomitant costs posed
Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey

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Johnson, Lorraine; Wilcox, Spencer; Mankoff, Jennifer

2014-01-01

Overview. The Centers for Disease Control and Prevention (CDC) health-related quality of life (HRQoL) indicators are widely used in the general population to determine the burden of disease, identify health needs, and direct public health policy. These indicators also allow the burden of illness to be compared across different diseases. Although Lyme disease has recently been acknowledged as a major health threat in the USA with more than 300,000 new cases per year, no comprehensive assessment of the health burden of this tickborne disease is available. This study assesses the HRQoL of patients with chronic Lyme disease (CLD) and compares the severity of CLD to other chronic conditions. Methods. Of 5,357 subjects who responded to an online survey, 3,090 were selected for the study. Respondents were characterized as having CLD if they were clinically diagnosed with Lyme disease and had persisting symptoms lasting more than 6 months following antibiotic treatment. HRQoL of CLD patients was assessed using the CDC 9-item metric. The HRQoL analysis for CLD was compared to published analyses for the general population and other chronic illnesses using standard statistical methods. Results. Compared to the general population and patients with other chronic diseases reviewed here, patients with CLD reported significantly lower health quality status, more bad mental and physical health days, a significant symptom disease burden, and greater activity limitations. They also reported impairment in their ability to work, increased utilization of healthcare services, and greater out of pocket medical costs. Conclusions. CLD patients have significantly impaired HRQoL and greater healthcare utilization compared to the general population and patients with other chronic diseases. The heavy burden of illness associated with CLD highlights the need for earlier diagnosis and innovative treatment approaches that may reduce the burden of illness and concomitant costs posed by this

ORIGINAL ARTICLES

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Department Of Surgery, Nelson R Mandela School of Medicine, University of KwaZu- lu-Natal. 2Head of .... There were 20 (12%) patients who were infected with HIV .... a specialist-led service for the management of acute gallstone disease.
Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions.

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Itabe, Hiroyuki; Kato, Rina; Sasabe, Naoko; Obama, Takashi; Yamamoto, Matsuo

2018-03-06

Oxidatively modified low-density lipoprotein (oxLDL) is known to be involved in various diseases, including cardiovascular diseases. The presence of oxLDL in the human circulatory system and in atherosclerotic lesions has been demonstrated using monoclonal antibodies. Studies have shown the significance of circulating oxLDL in various systemic diseases, including acute myocardial infarction and diabetic mellitus. Several different enzyme-linked immunosorbent assay (ELISA) procedures to measure oxLDL were utilized. Evidence has been accumulating that reveals changes in oxLDL levels under certain pathological conditions. Since oxLDL concentration tends to correlate with low-density lipoprotein (LDL)-cholesterol, the ratio of oxLDL and LDL rather than oxLDL concentration alone has been focused attention. In addition to circulating plasma, LDL and oxLDL are found in gingival crevicular fluid (GCF), where the ratio of oxLDL to LDL in GCF is much higher than in plasma. LDL and oxLDL levels in GCF show an increase in diabetic patients and periodontal patients, suggesting that GCF might be useful in examining systemic conditions. GCF oxLDL increased when the teeth were affected by periodontitis. It is likely that oxLDL levels in plasma and GCF could reflect oxidative stress and transfer efficacy in circulatory system. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Cushing’s disease – Same condition, different scenarios

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Adina Ghemigian

2018-03-01

Full Text Available Cushing’s disease is a rare pathology characterized by excess production of adrenocorticotropic hormone (ACTH secondary to a pituitary adenoma which stimulates adrenal cortisol secretion. The main consequences are the metabolic and cardiovascular complications, as well as osteoporosis and infection predisposition, which increase mortality in untreated patients. The first case presentation is about a patient with Cushing’s disease, surgically treated and cured, without any need for substitution or signs of pituitary-adrenal axis failure. The second case is a patient diagnosed with Cushing’s disease, with multiple complications, with clinical and hormonal relapse after selective adenomectomy and resistant to medical therapy, who is scheduled for reintervention. The third presentation is about a patient known with osteoporosis, diagnosed with Cushing’s disease based on the clinical appearance with bilateral adrenal adenomas, with left suprarenalectomy and pituitary gamma knife radiotherapy. We aim to introduce a pictorial assay consisting of a series of three cases, different from detection, management and outcome
Contributions of COPD, asthma, and ten comorbid conditions to health care utilization and patient-centered outcomes among US adults with obstructive airway disease.

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Murphy, Terrence E; McAvay, Gail J; Allore, Heather G; Stamm, Jason A; Simonelli, Paul F

2017-01-01

Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD), asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs) have not been previously reported. We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS) cohorts enrolled annually from 2008 through 2012 for 1 year. MEPS is a prospective observational study of US households recording self-reported COPD, asthma, and ten medical conditions: angina, arthritis, cancer, coronary heart disease, cognitive impairment, diabetes, hypertension, lung cancer, myocardial infarction, and stroke/transient ischemic attack. We studied the separate contributions of these conditions to health care utilization (all-cause and respiratory disease hospitalization, any emergency department [ED] visit, and six or more outpatient visits) and PCOs (seven or more days spent in bed due to illness, incident loss of mobility, and incident decline in self-perceived health). COPD made the largest contributions to all-cause and respiratory disease hospitalization and ED visits, while arthritis made the largest contribution to outpatient health care. Arthritis and COPD, respectively, made the greatest contributions to the PCOs. COPD made the largest and second largest contributions to health care utilization and PCOs among US adults with obstructive airway disease. The twelve medical conditions collectively accounted for between 52% and 61% of the health care utilization outcomes and between 53% and 68% of the PCOs. Cognitive impairment, diabetes, hypertension, and stroke also made significant contributions.
Oxidative conditions prevail in severe IUGR with vascular disease and Doppler anomalies.

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Maisonneuve, Emeline; Delvin, Edgard; Edgard, Annie; Morin, Lucie; Dubé, Johanne; Boucoiran, Isabelle; Moutquin, Jean-Marie; Fouron, Jean-Claude; Klam, Stephanie; Levy, Emile; Leduc, Line

2015-08-01

Intrauterine growth restriction (IUGR) and prenatal exposure to oxidative stress are thought to lead to increased risks of cardiovascular disease later in life. The objective of the present study was to document whether cord blood oxidative stress biomarkers vary with the severity of IUGR and of vascular disease in the twin pregnancy model in which both fetuses share the same maternal environment. This prospective cohort study involved dichorionic twin pairs, with one co-twin with IUGR. Oxidative stress biomarkers were measured in venous cord blood samples from each neonate of 32 twin pairs, and compared, according to severity of IUGR (IUGR <5th percentile), Doppler anomalies of the umbilical artery and early onset IUGR (in the second trimester) of the growth restricted twin. Oxidized Low-Density Lipoproteins (oxLDL) and Malondialdehyde (MDA) concentrations were increased proportionally in cases of severe IUGR. OxLDL concentrations were also increased in cases of IUGR with Doppler anomaly. Our data indicate that severe IUGR, is related to a derangement in redox balance, illustrated by increased venous cord blood oxidative stress biomarkers concentrations. Severe IUGR and IUGR with abnormal Doppler can be translated into conditions with intense oxidative stress.
Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease.

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Miyake, Teruki; Matsuura, Bunzo; Furukawa, Shinya; Todo, Yasuhiko; Yamamoto, Shin; Yoshida, Osamu; Imai, Yusuke; Watanabe, Takao; Yamamoto, Yasunori; Hirooka, Masashi; Tokumoto, Yoshio; Kumagi, Teru; Abe, Masanori; Seike, Hirotaka; Miyauchi, Shozo; Hiasa, Yoichi

2016-01-01

3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level. Therefore, hyperthyroidism may improve the pathological condition of NASH.
Dupuytren’s Disease: Predicting Factors and Associated Conditions. A Single Center Questionnaire-Based CaseControl Study

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Ilaria Morelli

2017-11-01

Full Text Available Background: Conflicting studies link several conditions and risk factors to Dupuytren’s disease (DD. A questionnaire-based case-control study was set to investigate associated conditions and clinical features of DD in a sample of Italian patients. The main purpose was the identification of predicting factors for: DD development; involvement of multiple rays; involvement of both hands; development of radial DD; development of recurrences and extensions. Methods: A self-administered questionnaire was used to investigate medical and drug histories, working and life habits, DD clinical features, familial history, recurrences and extensions. Binary logistic regression, Mann Whitney U-test and Fisher’s exact test were used for the statistical analysis. Results: A role in DD development was found for male sex, cigarette smoking, diabetes and heavy manual work. The development of aggressive DD has been linked to age, male sex, high alcohol intake, dyslipidemias and positive familial history. Conclusion: Further studies might explain the dual relationship between ischemic heart disease and DD. According to our results, the questionnaire used for this study revealed to be an easy-handling instrument to analyze the conditions associated to DD. Nevertheless, its use in further and larger studies is needed to confirm our results as well as the role of the questionnaire itself as investigation tool for clinical studies.
Pathophysiology of Cushing's disease.

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Fehm, H L; Voigt, K H

1979-01-01

standard roentgenograms of the head. Recent studies on the frequency of these large tumors do not support the hypothesis that adrenalectomy accelerates the progression of these tumors. In this case the term "Nelson's syndrome" would be uncessary. It is established that complete cure of Cushing's disease can be obtained in most patients with selective removal of a microadenoma from the pituitary gland. The current experience with this microsurgical procedure caused a renewed interest in Cushing's original suggestion that the disease is primarily a pituitary disorder. However, there are already a number of enigmatic observations. Possibly, the recent ultrastructural studies using immunocytochemical methods will resolve some of these problems. At this moment it is impossible to decide whether Cushing's disease is primarily a CNS or a pituitary disorder, when all arguments for one or the other hypothesis are taken into account...
COPD is frequent in conditions of comorbidity in patients treated with various diseases in a university hospital

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Akira Yamasaki

2010-09-01

Full Text Available Akira Yamasaki, Kiyoshi Hashimoto, Yasuyuki Hasegawa, Ryota Okazaki, Miki Yamamura, Tomoya Harada, Shizuka Ito, Soichiro Ishikawa, Hiroki Takami, Masanari Watanabe, Tadashi Igishi, Yuji Kawasaki, Eiji ShimizuDivision of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, JapanBackground: Chronic obstructive pulmonary disease (COPD is one of the leading causes of death and loss of disability-adjusted life-years. However, many COPD patients are not diagnosed because of underrecognition or underdiagnosis of this disease among many patients and physicians. One possible reason is underrecognition of spirometry. In this study, we examined the prevalence of airflow limitation and underlying disease in patients with airflow limitation.Methodology: From April 2006 to March 2008, patients who had spirometry performed were examined. The original disease of patients, pulmonary function tests, smoking status, and respiratory symptoms were surveyed from their medical records.Results: Of all patients who had spirometry performed, 15.8% showed airflow limitation (FEV1/FVC < 0.7. A variety of diseases were observed in patients with airflow limitation. Among all diseases, cardiovascular disease was the highest and gastrointestinal malignant disease had the second highest prevalence in patients with airflow limitation.Conclusion: COPD might be frequent in conditions of comorbidity in patients treated for various diseases. Attention should be paid to the possibility of co-existence of COPD and the influence of COPD on these patients.Keywords: airflow limitation, chronic obstructive pulmonary disease, comorbidity, spirometry, prevalence
Pneumococcal Pneumonia and Pandemic H1N1

Centers for Disease Control (CDC) Podcasts

2012-06-06

Dr. George Nelson, a CDC medical officer, discusses the relationship between pneumococcal pneumonia and Pandemic H1N1. Created: 6/6/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID). Date Released: 6/6/2012.
A study on periodontal disease and systemic disease relationship a hospital based study in Bangalore

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Sukhvinder Singh Oberoi

2013-01-01

Full Text Available Background: Periodontal deterioration has been reported to be associated with various systemic conditions like Cardiovascular disease, Diabetes, Respiratory disease, Liver cirrhosis, Bacterial Pneumonia, Nutritional deficiencies and adverse pregnancy outcomes. Aim: To assess the periodontal disease among patients with systemic disease/conditions. Materials and Method: A total of 500 patients with systemic disease/conditions (Diabetes, Cardiovascular disease, Respiratory disease and Renal disease and 500-age and gender matched controls without systemic disease/conditions were selected from the Government Hospitals in Bangalore City. The medical conditions were recorded and the periodontal status of the study population was assessed using the CPITN index. Results: The prevalence of CPITN Code 4 was found to be more among the patients with systemic disease/conditions (46.2%. The mean number of sextants with CPITN code 3 and 4 were more among the patients with systemic disease/conditions. The prevalence of CPITN code was found to be more among the patients with Respiratory disease whereas the mean number of sextants was found to be more among the patients with Diabetes, Cardiovascular and Renal disease. Conclusion: It may be concluded that the systemic diseases/conditions are associated with higher severity of periodontal disease.
Impact of Disease Prevalence Adjustment on Hospitalization Rates for Chronic Ambulatory Care-Sensitive Conditions in Germany.

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Pollmanns, Johannes; Romano, Patrick S; Weyermann, Maria; Geraedts, Max; Drösler, Saskia E

2018-04-01

To explore effects of disease prevalence adjustment on ambulatory care-sensitive hospitalization (ACSH) rates used for quality comparisons. County-level hospital administrative data on adults discharged from German hospitals in 2011 and prevalence estimates based on administrative ambulatory diagnosis data were used. A retrospective cross-sectional study using in- and outpatient secondary data was performed. Hospitalization data for hypertension, diabetes, heart failure, chronic obstructive pulmonary disease, and asthma were obtained from the German Diagnosis Related Groups (DRG) database. Prevalence estimates were obtained from the German Central Research Institute of Ambulatory Health Care. Crude hospitalization rates varied substantially across counties (coefficients of variation [CV] 28-37 percent across conditions); this variation was reduced by prevalence adjustment (CV 21-28 percent). Prevalence explained 40-50 percent of the observed variation (r = 0.65-0.70) in ACSH rates for all conditions except asthma (r = 0.07). Between 30 percent and 38 percent of areas moved into or outside condition-specific control limits with prevalence adjustment. Unadjusted ACSH rates should be used with caution for high-stakes public reporting as differences in prevalence may have a marked impact. Prevalence adjustment should be considered in models analyzing ACSH. © Health Research and Educational Trust.
Asthma and lung cancer, after accounting for co-occurring respiratory diseases and allergic conditions: a systematic review protocol.

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Denholm, Rachel; Crellin, Elizabeth; Arvind, Ashwini; Quint, Jennifer

2017-01-16

Asthma is one of the most frequently diagnosed respiratory diseases in the UK, and commonly co-occurs with other respiratory and allergic diseases, such as chronic obstructive pulmonary disease (COPD) and atopic dermatitis. Previous studies have shown an increased risk of lung cancer related to asthma, but the evidence is mixed when accounting for co-occurring respiratory diseases and allergic conditions. A systematic review of published data that investigate the relationship between asthma and lung cancer, accounting for co-occurring respiratory and allergic diseases, will be conducted to investigate the independent association of asthma with lung cancer. A systematic review will be conducted, and include original reports of cohort, cross-sectional and case-control studies of the association of asthma with lung cancer after accounting for co-occurring respiratory diseases. Articles published up to June 2016 will be included, and their selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A standardised data extraction form will be developed and pretested, and descriptive analyses will be used to summarise the available literature. If appropriate, pooled effect estimates of the association between asthma and lung cancer, given adjustment for a specific co-occurring condition will be estimated using random effects models. Potential sources of heterogeneity and between study heterogeneity will also be investigated. The study will be a review of published data and does not require ethical approval. Results will be disseminated through a peer-reviewed publication. International Prospective Register for Systematic Reviews (PROSPERO) number CRD42016043341. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
The comparison of socio-economic conditions and personal hygiene habits of neuro-Behçet's disease and multiple sclerosis patients.

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Pehlivan, Münevver; Kürtüncü, Murat; Tüzün, Erdem; Shugaiv, Erkingül; Mutlu, Melike; Eraksoy, Mefküre; Akman-Demir, Gülşen

2011-07-01

The "hygiene hypothesis" suggests that a reduction in the exposure to infectious agents due to improved health conditions has contributed to the increased incidence of autoimmune disorders in developed countries. In keeping with the hygiene hypothesis, many autoimmune disorders such as multiple sclerosis (MS) are more frequently observed in developed countries. To identify the relevance of hygiene hypothesis in neuro-Behçet's disease (NBD), another chronic inflammatory disease of the central nervous system, we developed and administered a multiple choice questionnaire to evaluate the hygiene conditions and practices of age and gender-matched NBD patients (n = 50) and control MS (n =5 0) and headache (n = 50) patients. Overall, MS patients had the highest socio-economic and hygiene features, whereas NBD patients displayed a lower socio-economic status group and showed poorer hygiene conditions than MS and headache controls. These poor hygiene conditions might be increasing the susceptibility of exposure to infectious agents that might, at least in part, trigger the inflammatory responses involved in NBD pathogenesis. Copyright © 2011 Elsevier GmbH. All rights reserved.
THE CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH MANDIBULAR FRACTURES IN COMBINATION WITH INFLAMMATORY DISEASES OF PERIODONTIUM IN DYNAMICS OF TREATMENT

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H.U. Bisultanov

2008-03-01

Full Text Available The immobilization of broken fragments by two-jaw anchor splints in patients with the mandibular fractures in a combination with inflammatory diseases ofperiodontium usually causes the exacerbation and progression of the diseases and growing progressively worsening ofperiodontium status. The intensity of these conditions depends on an initial status ofperiodontal tissue. The posttraumatic suppurative inflammatory complications of the mandibular fractures frequency depending on the initial stage of periodontal disease are marked.
A continuous high-resolution record of western South Island environmental change over the last 31,000 years from stable isotope analyses of two north-west Nelson speleothems

International Nuclear Information System (INIS)

Hellstrom, J.; McCulloch, M.; Stone, J.

1997-01-01

Core samples were taken through large sheets of calcite flowstone growing in two cave systems, Nettlebed, and Exhaleair, in north-west Nelson, New Zealand. The sampled flowstones are at elevations of 400 m asl and 600 m asl, and are both located 200m below the surface. Ten high-precision U-series dates, measured by thermal ionisation mass spectroemtry, indicate the Nettlebed flowstone grew continuously over the last 31 ka. The Exhaleair flowstone grew continuously over the last 16 ka, following a 50 ka hiatus in deposition. The speleothems from both caves show similar records of oxygen isotope variation over the last 16 ka. The carbon isotope record from Nettlebed shows considerable variation, of almost 10 per thousand from the last glacial maximum to the early Holocene. It is anticipated that these well-dated speleothem records will enable more accurate constraints to be placed on the timing of glacial advances and vegetation changes in the western South Island than are possible using the available radiocarbon ages alone. (author)
Characterization and selection of location for resistance to sugarcane brown rust disease under cuban conditions

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Joaquín Montalván Delgado

2016-01-01

Full Text Available The sugarcane brown rust disease is caused by fungus Puccinia melanocephala Sydow & P. Sydow and it is one of the more importance diseases. The environment where the sugarcane is cultivated is constituted by numerous factors and its combination contributes to the formation of different development and production conditions, what influences in the varietal disease resistance. With the objective of to characterize and to define the resistance tests location to the brown rust disease were carried out experiments in 6 location of the country. Eleven varieties and six patterns were studied. The climatic variables were analyzed during the period in each location and they were carried out evaluations in different ages of the plant and number of the leaves. The quantity of pustules, long of the most frequent pustules, size of the biggest pustules and area per - centage occupied by pustules were evaluated. The data were analyzed statistically. Differential behavior of the locations and the importance of the relative humidity and the temperatures in the manifestation of the disease symptoms were proven. All the locations were important although similarity exists between Matanzas and Villa Clara and between Camagüey and Holguín. Mayabeque and Santiago de Cuba didn’t present similarity with any other one. These 6 locations can be used for the resistance tests and to define the progenitors’ Santiago de Cuba, Holguín, Villa Clara and Mayabeque
Patient Perception of Treatment Burden is High in Celiac Disease Compared to Other Common Conditions

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Shah, Sveta; Akbari, Mona; Vanga, Rohini; Kelly, Ciaran P.; Hansen, Joshua; Theethira, Thimmaiah; Tariq, Sohaib; Dennis, Melinda; Leffler, Daniel A.

2014-01-01

Introduction The only treatment for celiac disease (CD) is life-long adherence to a gluten-free diet (GFD). Noncompliance is associated with signs and symptoms of celiac disease, yet long-term adherence rates are poor. It is not known how the burden of the GFD compares to other medical treatments, and there are limited data on the socio-economic factors influencing treatment adherence. In this study we compared treatment burden and health state in CD compared with other chronic illnesses and evaluated the relationship between treatment burden and adherence. Methods A survey was mailed to participants with: CD, gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), hypertension (HTN), diabetes mellitus (DM), congestive heart failure (CHF), and end stage renal disease on dialysis (ESRD). Surveys included demographic information and visual analog scales measuring treatment burden, importance of treatment, disease-specific and overall health status. Results We collected surveys from 341 celiac and 368 non-celiac participants. Celiac participants reported high treatment burden, greater than participants with GERD or HTN and comparable to ESRD. Conversely, patients with CD reported the highest health state of all groups. Factors associated with high treatment burden in CD included poor adherence, concern regarding food cost, eating outside the home, higher income, lack of college education and time limitations in preparing food. Poor adherence in CD was associated with increased symptoms, income, and low perceived importance of treatment. Discussion Participants with CD have high treatment burden but also excellent overall health status in comparison with other chronic medical conditions. The significant burden of dietary therapy for celiac disease argues for the need for safe adjuvant treatment as well as interventions designed to lower the perceived burden of the GFD. PMID:24980880
The effect of encoding condition on free recall in Parkinson's disease: incidental and intentional memory are equally affected.

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Ellfolk, Ulla; Huurinainen, Salla; Joutsa, Juho; Karrasch, Mira

2012-01-01

Free recall memory deficits are common at early stages of Parkinson's disease (PD). As most studies have used intentional memory tasks, there is little information on how non-intentional, incidental encoding conditions affect memory performance in PD. We studied possible differences between PD patients and controls on free recall using incidental and intentional visual memory tasks. Free recall was examined in relation to attentive/executive functioning and subjective memory complaints. A total of 29 non-demented, medicated PD patients (age 60, disease duration 19 months) and 29 healthy controls (age 61) participated in the study. Incidental free recall was studied using a memory-modification of the Boston naming test (Memo-BNT) and intentional free recall with the 20 Objects test. There was a significant main effect for group due to worse free recall performances in the PD group. No statistically significant interaction between group and encoding condition was observed. The free recall deficit in the PD group was related to cognitive/psychomotor slowing, but not to attentive/executive task demands, or to subjective memory complaints. The results indicate that PD patients are impaired on free recall irrespective of encoding condition.
Natural class of non-Peccei-Quinn models

International Nuclear Information System (INIS)

Barr, S.M.

1984-01-01

We discuss a class of models, not based on the Peccei-Quinn mechanism, that solve the strong CP problem. These are a generalization of a model of A. Nelson. Improved conditions are given for such models. These conditions are natural and in many simple models are automatically satisfied. 19 references

Peripartum hysterectomy: two years experience at Nelson Mandela ...

African Journals Online (AJOL)

EB

2009-01-31

Jan 31, 2009 ... secondary haemorrhage/ sepsis3 but with the use anti retro viral treatment there should be a decrease in this condition. Majority (76%) of patients had subtotal hysterectomies and the rest had total abdominal hysterectomies. Subtotal hysterectomy is routinely used for managing these patients and in a ...
Variation among sub-basins of the upper Nelson River in relationships between precipitation, runoff and the Pacific Decadal Oscillation

International Nuclear Information System (INIS)

McCullough, G.

2008-01-01

In this paper, I examine relationships between precipitation and river discharge in the Nelson River watershed and several global climate indices. Inter-decadal patterns in discharge and precipitation for several sub-basins closely tracked the Pacific Decadal Oscillation (PDO) through much of the 20th century. The PDO explained 53% of the variability in precipitation and 70% in discharge for the Red River (5-y averages) from 1915-1975. However, since 1975, both precipitation and discharge have increased relative to trend of the PDO. Winnipeg River discharge likewise increased relative to the PDO, but diverged earlier, beginning in 1965. The hydrograph of the Saskatchewan River followed the PDO only until mid-century, after which discharge declined relative to the PDO. The decline of discharge in the Saskatchewan River is not matched by consistent declines in precipitation, but may be partly due to consumptive use, mainly irrigation, and losses due to evaporation from large reservoirs created in the 1960s and 1970s. However, the increases in the Red and Winnipeg River are well-explained by increased spring and summer precipitation. For instance, precipitation was 20-30% higher in the decade 1996-2005 than in the previous decade. By examining historical data, we show the runoff coefficient to increase with increasing discharge, and that the proportional increase is greater in the Red than in the Winnipeg River basin. In the Red, the moderate difference in precipitation was amplified into a doubling of annual mean discharge. Comparing the same 2 periods, a smaller 10% increase in precipitation in the Winnipeg River basin explains a 27% increase in discharge. (author)
Evaluating the impact of a disease management program for chronic complex conditions at two large northeast health plans using a control group methodology.

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Schwerner, Henry; Mellody, Timothy; Goldstein, Allan B; Wansink, Daryl; Sullivan, Virginia; Yelenik, Stephan N; Charlton, Warwick; Lloyd, Kelley; Courtemanche, Ted

2006-02-01

The objective of this study was to observe trends in payer expenditures for plan members with one of 14 chronic, complex conditions comparing one group with a disease management program specific to their condition (the intervention group) and the other with no specific disease management program (the control group) for these conditions. The authors used payer claims and membership data to identify members eligible for the program in a 12-month baseline year (October 2001 to September 2002) and a subsequent 12-month program year (October 2002 to September 2003). Two payers were analyzed: one health plan with members primarily in New Jersey (AmeriHealth New Jersey [AHNJ]), where the disease management program was offered, and one affiliated large plan with members primarily in the metro Philadelphia area, where the program was not offered. The claims payment policy for both plans is identical. Intervention and control groups were analyzed for equivalence. The analysis was conducted in both groups over identical time periods. The intervention group showed statistically significant (p control group. Intervention group members showed a reduction in expenditures of -8%, while control group members showed an increase of +10% over identical time periods. Subsequent analyses controlling for outliers and product lines served to confirm the overall results. The disease management program is likely responsible for the observed difference between the intervention and control group results. A well-designed, targeted disease management program offered by a motivated, supportive health plan can play an important role in cost improvement strategies for members with complex, chronic conditions.
Proliferative kidney disease in brown trout: infection level, pathology and mortality under field conditions.

Science.gov (United States)

Schmidt-Posthaus, Heike; Hirschi, Regula; Schneider, Ernst

2015-05-21

Proliferative kidney disease (PKD) is an emerging disease threatening wild salmonid populations. In temperature-controlled aquaria, PKD can cause mortality rates of up to 85% in rainbow trout. So far, no data about PKD-related mortality in wild brown trout Salmo trutta fario are available. The aim of this study was to investigate mortality rates and pathology in brown trout kept in a cage within a natural river habitat known to harbor Tetracapsuloides bryosalmonae. Young-of-the-year (YOY) brown trout, free of T. bryosalmonae, were exposed in the River Wutach, in the northeast of Switzerland, during 3 summer months. Samples of wild brown trout caught by electrofishing near the cage location were examined in parallel. The incidence of PKD in cage-exposed animals (69%) was not significantly different to the disease prevalence of wild fish (82 and 80% in the upstream and downstream locations, respectively). The mortality in cage-exposed animals, however, was as low as 15%. At the termination of the exposure experiment, surviving fish showed histological lesions typical for PKD regression, suggesting that many YOY brown trout survive the initial infection. Our results at the River Wutach suggest that PKD in brown trout does not always result in high mortality under natural conditions.
Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness.

Science.gov (United States)

Yunus, Muhammad B

2008-06-01

To discuss the current terminologies used for fibromyalgia syndrome (FMS) and related overlapping conditions, to examine if central sensitivity syndromes (CSS) is the appropriate nosology for these disorders, and to explore the issue of disease versus illness. A literature search was performed through PubMed, Web of Science, and ScienceDirect using a number of keywords, eg, functional somatic syndromes, somatoform disorders, medically unexplained symptoms, organic and nonorganic, and diseases and illness. Relevant articles were then reviewed and representative ones cited. Terminologies currently used for CSS conditions predominantly represent a psychosocial construct and are inappropriate. On the other hand, CSS seems to be the logical nosology based on a biopsychosocial model. Such terms as "medically unexplained symptoms," "somatization," "somatization disorder," and "functional somatic syndromes" in the context of CSS should be abandoned. Given current scientific knowledge, the concept of disease-illness dualism has no rational basis and impedes proper patient-physician communication, resulting in poor patient care. The concept of CSS is likely to promote research, education, and proper patient management. CSS seems to be a useful paradigm and an appropriate terminology for FMS and related conditions. The disease-illness, as well as organic/non-organic dichotomy, should be rejected.
The course of pregnancy and the condition of infants born to patients treated for Hodgkin's disease

International Nuclear Information System (INIS)

Bajsogolov, G.D.; Shishkin, I.P.

1985-01-01

The paper is concerned with some data on the pregnancy and delivery of 78 patients with Hodgkin's disease as well as on the condition of 89 infants born to them following radiation and combined treatment. It was established that pregnancy and delivery in most of the women were normal, the infants' psychomotor development (at the age of 1 to 14) was in accordance with age
Comment on “The role of interbasin groundwater transfers in geologically complex terranes, demonstrated by the Great Basin in the western United States”: report published in Hydrogeology Journal (2014) 22:807–828, by Stephen T. Nelson and Alan L. Mayo

Science.gov (United States)

Masbruch, Melissa D.; Brooks, Lynette E.; Heilweil, Victor M.; Sweetkind, Donald S.

2015-01-01

The subject article (Nelson and Mayo 2014) presents an overview of previous reports of interbasin flow in the Great Basin of the western United States. This Comment is presented by authors of a cited study (comprising chapters in one large report) on the Great Basin carbonate and alluvial aquifer system (GBCAAS; Heilweil and Brooks 2011; Masbruch et al. 2011; Sweetkind et al. 2011a, b), who agree that water budget imbalances alone are not enough to accurately quantify interbasin flow; however, it is proposed that statements made in the subject article about the GBCAAS report are inaccurate. The Comment authors appreciate the opportunity to clarify some statements made about the work.
Clinical Classification of Diseases and Conditions of Mammary Glands in Children and Adolescents

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Marina L. Travina

2016-01-01

Full Text Available The article describes the proposed current clinical classification of breast diseases and pathology in childhood and adolescence. The classification is based on the analysis of data obtained from the examination and follow-up monitoring of 6,126 children for up to 8 years. The clinical classification is recommended for widespread use in the work of primary care physicians who conduct follow-up monitoring. The use of this classification creates groups for referral to specialists for further examination and further treatment and follow-up monitoring. The classification is based on the separation of physiological (normal conditions and pathological processes, as well as on temporary deviations from normal development (temporary conditions not leading to pathological processes and anomalies in development of mammary glands and nipple-areolar complex. If any abnormalities are suspected, a patient shall be sent to a mammologist for further examination and US scanning. Control of growth and development of mammary glands in childhood and adolescence ensures early detection of abnormalities and allows necessary remedial measures to protect reproductive health.
Gastroesophageal reflux disease in Asia: a condition in evolution.

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Ho, Khek Yu

2008-05-01

Widespread epidemiological changes, rising prevalence and gradual shifts in patterns of disease manifestations: this is the changing face of gastroesophageal reflux disease (GERD) in Asia. Are we witnessing a disease in evolution or merely the result of increased and more accurate case reporting that comes with advancing diagnostic technology, better medical facilities and heightened awareness of the disease? Do the figures reported really reflect the actual scenario or is there more to it than meets the eye? In this article, we take you back in time to review relevant developments over the past decade or so. We will draw on findings from across Asia, take an in-depth look at prevailing trends and patterns and examine some of the most plausible explanations behind the dynamics of this epidemiological transition.
Contributions of COPD, asthma, and ten comorbid conditions to health care utilization and patient-centered outcomes among US adults with obstructive airway disease

Directory of Open Access Journals (Sweden)

Murphy TE

2017-08-01

Full Text Available Terrence E Murphy,1 Gail J McAvay,1 Heather G Allore,1 Jason A Stamm,2 Paul F Simonelli2 1Department of Internal Medicine, Section of Geriatrics, Yale University School of Medicine, New Haven, CT, USA; 2Department of Internal Medicine, Section of Thoracic Medicine, Geisinger Medical Center, Danville, PA, USA Background: Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD, asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs have not been previously reported.Methods: We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS cohorts enrolled annually from 2008 through 2012 for 1 year. MEPS is a prospective observational study of US households recording self-reported COPD, asthma, and ten medical conditions: angina, arthritis, cancer, coronary heart disease, cognitive impairment, diabetes, hypertension, lung cancer, myocardial infarction, and stroke/transient ischemic attack. We studied the separate contributions of these conditions to health care utilization (all-cause and respiratory disease hospitalization, any emergency department [ED] visit, and six or more outpatient visits and PCOs (seven or more days spent in bed due to illness, incident loss of mobility, and incident decline in self-perceived health.Results: COPD made the largest contributions to all-cause and respiratory disease hospitalization and ED visits, while arthritis made the largest contribution to outpatient health care. Arthritis and COPD, respectively, made the greatest contributions to the PCOs.Conclusion: COPD made the largest and second largest contributions to health care utilization and PCOs among US adults with obstructive airway disease. The twelve medical conditions collectively accounted for between 52% and 61% of the health care utilization outcomes and between 53
Busulfan, Fludarabine, and Thiotepa Conditioning Regimen for Non Malignant Disease

Science.gov (United States)

2018-04-19

Bone Marrow Failure Syndrome; Thalassemia; Sickle Cell Disease; Diamond Blackfan Anemia; Acquired Neutropenia in Newborn; Acquired Anemia Hemolytic; Acquired Thrombocytopenia; Hemophagocytic Lymphohistiocytoses; Wiskott-Aldrich Syndrome; Chronic Granulomatous Disease; Common Variable Immunodeficiency; X-linked Lymphoproliferative Disease; Severe Combined Immunodeficiency; Hurler Syndrome; Mannosidosis; Adrenoleukodystrophy
Vowel Acoustics in Parkinson's Disease and Multiple Sclerosis: Comparison of Clear, Loud, and Slow Speaking Conditions

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Tjaden, Kris; Lam, Jennifer; Wilding, Greg

2013-01-01

Purpose: The impact of clear speech, increased vocal intensity, and rate reduction on acoustic characteristics of vowels was compared in speakers with Parkinson's disease (PD), speakers with multiple sclerosis (MS), and healthy controls. Method: Speakers read sentences in habitual, clear, loud, and slow conditions. Variations in clarity,…
Postpartum body condition score and results from the first test day milk as predictors of disease, fertility, yield, and culling in commercial dairy herds.

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Heuer, C; Schukken, Y H; Dobbelaar, P

1999-02-01

The study used field data from a regular herd health service to investigate the relationships between body condition scores or first test day milk data and disease incidence, milk yield, fertility, and culling. Path model analysis with adjustment for time at risk was applied to delineate the time sequence of events. Milk fever occurred more often in fat cows, and endometritis occurred between calving and 20 d of lactation more often in thin cows. Fat cows were less likely to conceive at first service than were cows in normal condition. Fat body condition postpartum, higher first test day milk yield, and a fat to protein ratio of > 1.5 increased body condition loss. Fat or thin condition or condition loss was not related to other lactation diseases, fertility parameters, milk yield, or culling. First test day milk yield was 1.3 kg higher after milk fever and was 7.1 kg lower after displaced abomasum. Higher first test day milk yield directly increased the risk of ovarian cyst and lameness, increased 100-d milk yield, and reduced the risk of culling and indirectly decreased reproductive performance. Cows with a fat to protein ratio of > 1.5 had higher risks for ketosis, displaced abomasum, ovarian cyst, lameness, and mastitis. Those cows produced more milk but showed poor reproductive performance. Given this type of herd health data, we concluded that the first test day milk yield and the fat to protein ratio were more reliable indicators of disease, fertility, and milk yield than was body condition score or loss of body condition score.
Fungal diseases of tree stands under urbanized conditions of Moscow

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Smirnova Oksana G.

2013-01-01

Full Text Available Phytosanitary and ecological estimation of tree-stands has been conducted at the Forest Experimental Station of Moscow Agricultural Academy and parks of Northeast of Moscow in 2007-2011. Fomes fomentarius was proved to be a very serious pathogen of trees under conditions of Moscow, Piptoporus betulinus, Phellinus igniarius, and Fomitopsis pinicola also occurred and caused damage to trees. This rather bad phytosanitary situation depends on alarming ecological situation in Moscow. At the Forest Experimental Station of Moscow Agricultural Academy a number and cover of lichens decreased. In general, all trees in Moscow are in dynamic equilibrium with the urbanized environment. In connection with this, the following classification of tree-stands was proposed for the urbanized environment: 1 - healthy trees, 2 - affected trees which can be managed, 3 - dry woods, 3a - very diseased. Many tree-stands in investigated regions of Moscow are found to belong to the groups 2 and 3c. All tree-stands must be carefully monitored and managed in order to provide a well-timed decision on the support system for preservation of trees as ‘lungs of city’ and avoid unpredictable tree falling which put people and traffic at risk.
[Influence of the working conditions on sickness absence due to common diseases].

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Vaquero-Álvarez, Manuel; Álvarez-Theurer, Esther; Romero Saldaña, Manuel

2018-04-01

To estimate the importance of the working environment in sickness absence, as well as to show possible relationships with clinical-work variables. A descriptive observational study. SITE: Medical Inspection of an Andalusian province. A total of 1016 workers on certified sick leave due to a common illness. A self-report questionnaire was used to collect demographic data, profession, activity, risk assessment, and perceived occupational cause, on patients who voluntarily gave their consent when they were reviewed during 2015. The illness that caused certified sickness absences was verified in the computerised medical records. Using criteria applied by experts, the role of working conditions in each episode of certified sick leave was assessed. Bivariate and multivariate analyses were performed to determine any relationships between the variables. An inadequate work environment was found in 17.1% of the sickness processes. Health and hospitality services activities have a significant association with working conditions as a cause of sick leave (P<.001). With respect to diagnosis, anxiety-depressive disorders (P<.01) and low back pain (P<.05) were associated with working conditions. The factors related to certified sickness absence and work environment were: residence (OR=0.34, 0.21-0.6), normal/higher education (OR=1.7, 1.2-2.4), (OR=2.0 1.3-3.1), large companies (OR=1.97, 1.3-2.9), and job (OR=2.7, 1.6-3, 2). Sickness absence is affected by factors related to the work environment. Specific preventive actions for workers at their workplace could reduce work related diseases classified as a common illness. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
IgG4-related disease -Mechanistic insights from both clinical and immunologic understanding of this condition.

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Maehara, Takashi

2017-01-01

IgG4-related disease (IgG4-RD) is a chronic inflammatory disease characterized by tumescent lesions with characteristic storiform fibrosis, obliterative phlebitis and a marked lymphoplasmacytic infiltrate that includes a large number of IgG4 positive plasma cells. It's widely accepted that rituximab-mediated B cell depletion therapy is effective for this disease. Important mechanistic insights correlated with the pathogenesis of IgG4-RD have been gradually disclosed from studies of patients treated by B cell depletion. 1) IgG4-RD patients have the large clonal expansion of activated plasmablasts and CD4 + CTLs, so this disease might be antigen-driven. 2) CD4 + CTLs are the dominant population in affected tissues, on the other hands direct examination of T H1 and T H2 cells in tissues reveal that these subsets are sparse. 3) CD4 + CTLs into affected lesions secret cytotoxic, inflammatory, and pro-fibrotic cytokines, indicating reactivation by antigen in tissue sites. 4) The decline in CD4 + CTLs number by B cell depletion is associated with clinical remission of IgG4-RD patients. 5) CD4 + CXCR5 + T FH cells that express IL-4 are located outside germinal centers and specialized T FH cells that expanded dramatically in conditions with polarized class switching to IgG4. These results suggested that the disease pathogenesis might be based on orchestrating of activated plasmablasts, CD4 + CTLs, and T FH cells.
Women's Heart Disease: Heart Disease Risk Factors

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... this page please turn JavaScript on. Feature: Women's Heart Disease Heart Disease Risk Factors Past Issues / Winter 2014 Table ... or habits may raise your risk for coronary heart disease (CHD). These conditions are known as risk ...
Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.

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Güngör, Tayfun; Teira, Pierre; Slatter, Mary; Stussi, Georg; Stepensky, Polina; Moshous, Despina; Vermont, Clementien; Ahmad, Imran; Shaw, Peter J; Telles da Cunha, José Marcos; Schlegel, Paul G; Hough, Rachel; Fasth, Anders; Kentouche, Karim; Gruhn, Bernd; Fernandes, Juliana F; Lachance, Silvy; Bredius, Robbert; Resnick, Igor B; Belohradsky, Bernd H; Gennery, Andrew; Fischer, Alain; Gaspar, H Bobby; Schanz, Urs; Seger, Reinhard; Rentsch, Katharina; Veys, Paul; Haddad, Elie; Albert, Michael H; Hassan, Moustapha

2014-02-01

In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients. This prospective study was done at 16 centres in ten countries worldwide. Patients aged 0-40 years with chronic granulomatous disease were assessed and enrolled at the discretion of individual centres. Reduced-intensity conditioning consisted of high-dose fludarabine (30 mg/m(2) [infants HLA-matched related-donors or HLA-9/10 or HLA-10/10 matched unrelated-donors were infused. The primary endpoints were overall survival and event-free survival (EFS), probabilities of overall survival and EFS at 2 years, incidence of acute and chronic GVHD, achievement of at least 90% myeloid donor chimerism, and incidence of graft failure after at least 6 months of follow-up. 56 patients (median age 12·7 years; IQR 6·8-17·3) with chronic granulomatous disease were enrolled from June 15, 2003, to Dec 15, 2012. 42 patients (75%) had high-risk features (ie, intractable infections and autoinflammation), 25 (45%) were adolescents and young adults (age 14-39 years). 21 HLA-matched related-donor and 35 HLA-matched unrelated-donor transplants were done. Median time to engraftment was 19 days (IQR 16-22) for neutrophils and 21 days (IQR 16-25) for platelets. At median follow-up of 21 months (IQR 13-35) overall survival was 93% (52 of 56) and EFS was 89% (50 of 56). The 2-year probability of overall survival was 96% (95% CI 86·46-99·09) and of EFS was 91% (79·78-96·17). Graft-failure occurred in 5% (three of 56) of patients. The cumulative incidence of acute GVHD of grade III-IV was 4% (two of 56) and of chronic graft-versus-host disease was 7% (four of 56). Stable (≥90%) myeloid
Exercise as a Time-conditioning Effector in Chronic Disease: a Complementary Treatment Strategy

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Luis F. B. P. Costa Rosa

2004-01-01

Full Text Available Exercise has been widely believed to be a preventive and therapeutic aid in the treatment of various pathophysiological conditions such as cardiovascular disease and cancer. A common problem associated with such pathologies is cachexia, characterized by progressive weight loss and depletion of lean and fat body mass, and is linked to poor prognosis. As this syndrome comprises changes in many physiological systems, it is tempting to assume that the modulation of the psychoneuroimmunoendocrine axis could attenuate or even prevent cachexia progression in cancer patients. Cancer cachexia is characterized by a disruption in the rhythmic secretion of melatonin, an important time-conditioning effector. This hormone, secreted by the pineal gland, transmits circadian and seasonal information to all organs and cells of the body, synchronizing the organism with the photoperiod. Considering that exercise modulates the immune response through at least two different mechanisms—metabolic and neuroendocrine—we propose that the adoption of a regular exercise program as a complementary strategy in the treatment of cancer patients, with the exercise bouts regularly performed at the same time of the day, will ameliorate cachexia symptoms and increase survival and quality of life.
Provision of educationally related services for children and adolescents with chronic diseases and disabling conditions.

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Cartwright, J Daniel

2007-06-01

Children and adolescents with chronic diseases and disabling conditions often need educationally related services. As medical home providers, physicians and other health care professionals can assist children, adolescents, and their families with the complex federal, state, and local laws, regulations, and systems associated with these services. Expanded roles for physicians and other health care professionals in individualized family service plan, individualized education plan, and Section 504 plan development and implementation are recommended. Recent updates to the Individuals With Disabilities Education Act will also affect these services. Funding for these services by private and nonprivate sources also continue to affect the availability of these educationally related services. The complex range of federal, state, and local laws, regulations, and systems for special education and related services for children and adolescents in public schools is beyond the scope of this statement. Readers are referred to the American Academy of Pediatrics policy statement "The Pediatrician's Role in Development and Implementation of an Individual Education Plan (IEP) and/or an Individual Family Service Plan (IFSP)" for additional background materials. The focus of this statement is the role that health care professionals have in determining and managing educationally related services in the school setting. This policy statement is a revision of a previous statement, "Provision of Educationally Related Services for Children and Adolescents With Chronic Diseases and Disabling Conditions," published in February 2000 by the Committee on Children With Disabilities (http://aappolicy.aappublications.org/cgi/content/full/pediatrics;105/2/448).

An assessment of the relationship of physical activity, obesity, and chronic diseases/conditions between active/obese and sedentary/ normal weight American women in a national sample.

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Pharr, J R; Coughenour, C A; Bungum, T J

2018-03-01

Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data. Weighted descriptive statistics were performed to describe the demographic characteristics of the two groups. We calculated odds ratios and adjusted odds ratios for chronic diseases and conditions comparing highly active/obese women with inactive/normal weight women. Highly active/obese women were more likely to report risk factors (hypertension, high cholesterol, and diabetes) for coronary heart disease (CHD) and cardiovascular disease (CVD) than inactive/normal weight women; however, they did not have increased rates of CVD, CHD, or heart attack and had decreased risk for stroke. Highly active/obese women had increased risk for asthma, arthritis, and depression, but not for cancer, kidney disease, or chronic obstructive pulmonary disease. Highly active/obese women appear to be staving off the actual development of CHD and CVD; however, further research is needed to understand the long-term health benefits of physical activity among obese women. Copyright © 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer

Science.gov (United States)

2008-09-01

independent prostate cancer. J Clin Oncol 22, 3323–3329. [115] Tiffany NM, Wersinger EM, Garzotto M, and Beer TM (2004). Imatinib mesylate and zoledronic...Inhibition of Akt pathways EC Nelson et al 335 Prostate Cancer and Prostatic Diseases addition, some Asian forms of fermented soy, such as miso, nattou and
Are gender differences in health-related quality of life attributable to sociodemographic characteristics and chronic disease conditions in elderly people?

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Karimollah Hajian-Tilaki

2017-01-01

Full Text Available Background: The objective of this study was to determine the gender differences in health-related quality of life (HRQoL and to indicate to what extent this difference can be explained by differential in demographic and chronic disease conditions in Iranian elderly people. Methods: This analysis was carried out on cross-sectional data of QoL assessment among 750 elderly individuals aged 60–90 years who were dwelling in urban population of Babol, the North of Iran. The multiple linear regression model was used to estimate the association between gender and HRQoL after controlling sociodemographic characteristics and chronic disease conditions. Results: Women had significantly lower score in HRQoL in all subscales compared with men after adjusting several confounding factors (P = 0.001. The unadjusted mean difference in overall HRQoL scores was −11.2 (95% confidence interval [CI]: −13.8, −8.6 points, but it was reduced to −6.5 (95% CI: −9.0, −3.9 points between gender after adjusting by age, educational level, living status, physical activity, smoking, abdominal obesity, diabetes, and hypertension. Conclusions: Adjusting for sociodemographic and chronic disease conditions reduced the effect size of poorer HRQoL for women compared with men but did not remove the sex differences. The poorer scores of HRQoL in Iranian women needs further physical, psychological, and social supports in elderly.
Visões e construções sobre povo e raça no campo cinematográfico brasileiro dos anos 1950: as teses de Solano Trindade e de Nelson Pereira dos Santos

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Pedro Vinicius Asterito Lapera

2015-08-01

Full Text Available This article aims to address two thesis presented in the Congress of the Brazilian Film in the 1950s to relate them to the beggining of formation of the Brazilian cinematographic field. More precisely, we will analyze Folclore e Cinema, thesis defended by Solano Trindade in the I Congresso Nacional do Cinema Brasileiro; and O problema do conteúdo no cinema brasileiro, presented by Nelson Pereira dos Santos in the I Congresso Paulista do Cinema Brasileiro. From them, we will analyze which images of Brazilian people these thesis articulated in their defenses. Our hypothesis is that, in order to use Gilberto Freyre’s ideas, these intellectuals chose the image of the Brazilian people as a racially, ethnically and culturally heterogeneous people, but in the process of integration. This is not to say that they only reproduce these ideas, but actively used in shaping the habitus of cinematographic field at that time.
On the correspondence between data revision and trend-cycle decomposition

NARCIS (Netherlands)

Dungey, M.; Jacobs, J. P. A. M.; Tian, J.; van Norden, S.

2013-01-01

This article places the data revision model of Jacobs and van Norden (2011) within a class of trend-cycle decompositions relating directly to the Beveridge-Nelson decomposition. In both these approaches, identifying restrictions on the covariance matrix under simple and realistic conditions may
A rare and cryptic endemic of the Central Rocky Mountains, U.S.A: The distribution of the Arapahoe snowfly, Arsapnia arapahoe (Nelson & Kondratieff, 1988) (Plecoptera: Capniidae)

Science.gov (United States)

Fairchild, Matthew P.; Belcher, Thomas P.; Zuellig, Robert E.; Vieira, Nicole K.M.; Kondratieff, Boris C.

2017-01-01

The Arapahoe snowfly, Arsapnia arapahoe (Nelson & Kondratieff, 1988) (Plecoptera: Capniidae) is a candidate species warranted for listing under the Endangered Species Act. Prior to this study, A. arapahoe was known from only two tributaries of the Cache la Poudre River in Larimer County, Colorado: Young Gulch and Elkhorn Creek. The objectives of this study were to determine the distribution of this endemic stonefly, and to identify sympatric species as possible surrogate indicators of its occurrence. Eighty-four streams were sampled within the expected geographical range and emergence time-period from 2013 to 2017. Adults of A. arapahoe were discovered in 19 first-, second-, and fourth-order streams beyond the original type localities tributary to the Cache la Poudre River. The new and recently recorded localities were discovered in the Big Thompson River, St. Vrain River, Boulder Creek, and Upper South Platte River Watersheds. Two species, A. decepta (Banks, 1897) and Capnia gracilaria Claassen, 1924, always co-occurred with A. arapahoe, suggesting this species pair may serve as a surrogate indicator of suitable stream habitat for A. arapahoe. Suggestions for future investigation into the distribution, life-history, and habitat of A. arapahoe are presented to aid the conservation of this rare and endemic Colorado stonefly.
Occupational reporiductive system diseases in female workers employed at worplaces with harmful working conditions

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M.A. Fesenko

2017-09-01

Full Text Available The paper outlines the data obtained in the course of long-term research dedicated to studying the extent to which re-productive system pathologies in workers with high-risk occupations are occupationally induced. Their peculiarity is joint impacts of various occupational factors (for example, impacts exerted by chemicals together with physical and biological factors, and labor hardness and intensity as well on a female body. Our research goal was to examine the extent to which reproductive system pathologies in workers with high-risk occupations were occupationally induced. To achieve it, we applied statistical estimate of correlation between health disorders and work. Our occupational group included a number of occupations with harmful or hazardous working conditions in civil en-gineering, metallurgy, chemical industry, polymer-processing industry, and health care as well. As a rule, working condi-tions class of workers from the examined groups varied from 3.1 to 3.3; and occupation with permissible working conditions were used as a comparative group. The research results revealed that there are certain occupations with high risk of reproductive health disorders evolvement and infants development pathologies evolvement. They are: – model makers and checkers in civil engineering and crane operators at a metallurgic plant; – analysts at chemical analysis laboratories, chemical engineers in chemical industry (including petrochemical plants, polymer-processing plants, and organic synthesis plants; – surgeons, obstetrician-gynecologists, midwives, surgical nurses working in in-patient departments. Estimate of correlation and occupational dependence of reproductive system diseases on working conditions revealed that women with harmful working conditions (3.1–3.3 hazard class had defective pregnancies or labor pathologies which had strong and average correlation with working conditions. Health disorders in newborns were estimated as per very
Novel Nitroxide Resuscitation Strategies in Experimental Traumatic Brain Injury

Science.gov (United States)

2010-03-01

conflicting financial interests exist. References Barron, K.D., Dentinger, M.P., Kimelberg, H.K., Nelson, L.R., Bourke , R.S., Keegan, S., Mankes, R...fects of anesthetics on splanchnic arterial blood flow during hemorrhagic shock. J. Appl. Physiol. 76, 2304–2309. Nelson, L.R., Bourke , R.S., Popp...model, in: Neural Trauma. A.J. Popp, R.S. Bourke , L.R. Nelson, H.K. Kimelberg (eds), Raven Press: New York, pps. 297–311. Nelson, T.J., Wall, D.B
Spatial Distribution of Coffee Wilt Disease Under Roguing and Replanting Conditions: A Case Study from Kaweri Estate in Uganda.

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Pinard, F; Makune, S E; Campagne, P; Mwangi, J

2016-11-01

Based on time and spatial dynamic considerations, this study evaluates the potential role of short- and long-distance dispersal in the spread of coffee wilt disease (CWD) in a large commercial Robusta coffee estate in Uganda (Kaweri, 1,755 ha) over a 4-year period (2008 to 2012). In monthly surveys, total disease incidence, expansion of infection foci, and the occurrence of isolated infected trees were recorded and submitted to spatial analysis. Incidence was higher and disease progression faster in old coffee plantings compared with young plantings, indicating a lack of efficiency of roguing for reducing disease development in old plantings. At large spatial scale (approximately 1 km), Moran indices (both global and local) revealed the existence of clusters characterized by contrasting disease incidences. This suggested that local environmental conditions were heterogeneous or there were spatial interactions among blocks. At finer spatial scale (approximately 200 m), O-ring statistics revealed positive correlation between distant infection sites across distances as great as 60 m. Although these observations indicate the role of short-distance dispersal in foci expansion, dispersal at greater distances (>20 m) appeared to also contribute to both initiation of new foci and disease progression at coarser spatial scales. Therefore, our results suggested the role of aerial dispersal in CWD progression.
Mortality in hyperglycemic crisis: a high association with infections and cerebrovascular disease.

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Ekpebegh, C; Longo-Mbenza, B

2013-06-01

Aim of the present study was to determine syndrome specific mortality rates and the precipitating factors associated with deaths following admission for hyperglycemic crisis to a high care unit. Retrospective review of medical records for hyperglycemic crisis at Nelson Mandela Academic Hospital, Mthatha, Eastern Cape Province of South Africa from February 1 2010 to January 31 2011. All admissions were initially into the high care unit. The overall mortality rates (per admissions) was 13.9% (N.=15/108) with syndrome specific mortality rates (per admissions) of 11.9% (N.=8/67), 0% (N.=0/8) and 21.2% (N.=7/33) respectively for diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS) and hyperglycemia with dehydration (HD). The precipitating factors that were mainly associated with mortality were infections and cerebrovascular disease (CVD). The patients with CVD who died were all unconscious. There were no deaths where non-compliance with hypoglycaemic agents (14.8%, N.=16/108) was the precipitating factor. The overall mortality rates (per admissions) following high care unit admissions for hyperglycemic crisis was 13.9% with infections and CVD as the precipitating factors most associated with deaths.
Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

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Dubal Dena B

2012-11-01

Full Text Available Abstract Biologic sex and gonadal hormones matter in human aging and diseases of aging such as Alzheimer’s – and the importance of studying their influences relates directly to human health. The goal of this article is to review the literature to date on sex and hormones in mouse models of Alzheimer’s disease (AD with an exclusive focus on interpreting the relevance of findings to the human condition. To this end, we highlight advances in AD and in sex and hormone biology, discuss what these advances mean for merging the two fields, review the current mouse model literature, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in this important area. Unraveling human relevant pathways in sex and hormone-based biology may ultimately pave the way to novel and urgently needed treatments for AD and other neurodegenerative diseases.
Validation of the shortened Perceived Medical Condition Self-Management Scale in patients with chronic disease.

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Wild, Marcus G; Ostini, Remo; Harrington, Magdalena; Cavanaugh, Kerri L; Wallston, Kenneth A

2018-05-21

Self-efficacy, or perceived competence, has been identified as an important factor in self-management behaviors and health outcomes in patients with chronic disease. Measures of self-management self-efficacy are currently available for multiple forms of chronic disease. One established measure is the 8-item Perceived Medical Condition Self-Management Scale (PMCSMS). This study investigated the use of the PMCSMS in samples of patients with a chronic disease to develop an abbreviated version of the scale that could be more readily used in clinical contexts or in large population health cohort studies. The PMCSMS was administered as either a generic scale or as a disease-specific scale. The results of analyses using item response theory and classical test theory methods indicated that using 4 items of the scale resulted in similar internal consistency (α = .70-0.90) and temporal stability (test-retest r = .75 after 2 to 4 weeks) to the 8-item PMCSMS (r = .81 after 2 to 4 weeks). The 4 items selected had the greatest discriminability among participants (α parameters = 2.49-3.47). Scores from both versions also demonstrated similar correlations with related constructs such as health literacy (r = .13-0.29 vs. 0.14-0.27), self-rated health (r = .17-0.48 vs. 0.26-0.50), social support (r = .21-0.32 vs. 0.25-0.34), and medication adherence (r = .20-0.24 vs. 0.20-0.25). The results of this study indicate that 4-item PMCSMS scores are equally valid but more efficient, and have the potential to be beneficial for both research and clinical applications. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Increased theta band EEG power in sickle cell disease patients

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Case M

2017-12-01

Full Text Available Michelle Case,1 Sina Shirinpour,1 Huishi Zhang,1 Yvonne H Datta,2 Stephen C Nelson,3 Karim T Sadak,4 Kalpna Gupta,2 Bin He1,5 1Department of Biomedical Engineering, 2Department of Medicine, University of Minnesota, 3Pediatric Hematology-Oncology, Children’s Hospitals and Clinics of Minnesota, 4Pediatric Hematology-Oncology, University of Minnesota Masonic Children’s Hospital, 5Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN, USA Objective: Pain is a major issue in the care of patients with sickle cell disease (SCD. The mechanisms behind pain and the best way to treat it are not well understood. We studied how electroencephalography (EEG is altered in SCD patients. Methods: We recruited 20 SCD patients and compared their resting state EEG to that of 14 healthy controls. EEG power was found across frequency bands using Welch’s method. Electrophysiological source imaging was assessed for each frequency band using the eLORETA algorithm. Results: SCD patients had increased theta power and decreased beta2 power compared to controls. Source localization revealed that areas of greater theta band activity were in areas related to pain processing. Imaging parameters were significantly correlated to emergency department visits, which indicate disease severity and chronic pain intensity. Conclusion: The present results support the pain mechanism referred to as thalamocortical dysrhythmia. This mechanism causes increased theta power in patients. Significance: Our findings show that EEG can be used to quantitatively evaluate differences between controls and SCD patients. Our results show the potential of EEG to differentiate between different levels of pain in an unbiased setting, where specific frequency bands could be used as biomarkers for chronic pain. Keywords: sickle cell disease, electroencephalography, chronic pain, electrophysiological source imaging, thalamocortical dysrhythmia
Somatic Diseases and Conditions Before the First Diagnosis of Schizophrenia

DEFF Research Database (Denmark)

Sørensen, Holger J; Nielsen, Philip Finn Rising; Benros, Michael E

2015-01-01

OBJECTIVE: Schizophrenia is associated with excess physical comorbidity. Yet, to our knowledge, large studies are lacking on the associations with somatic diseases before the onset of schizophrenia. The authors conducted a nationwide study of the full spectrum of treated somatic diseases before t...
Trust and memory: organizational strategies, institutional conditions and trust negotiations in specialty clinics for Alzheimer's disease.

Science.gov (United States)

Beard, Renée L

2008-03-01

Clinicians aim to establish trust during medical encounters because, without it, health consumers may not seek medical care, consider their diagnoses legitimate, or adhere to treatment regimens. This paper examines the identification and treatment of memory loss within two specialty clinics to understand how cultural dynamics, such as organizational ethos and work practices, influence the social fabric of cognitive evaluations. Ethnographic data suggest important historical and cultural differences in the approaches to Alzheimer's disease (AD). Organizational routines, however, support a common goal, that of moving individuals from "potential patients" to patients, and ultimately research subjects, through establishing trust. Although the processes through which trust is potentially achieved, or the social conditions of trust, were similar at the sites, the object of trust was different. Whereas one clinic encouraged trust in collective medical expertise, the other focused on trust in specific clinicians. These conditions affect the clinical consequences of trust, particularly how and when the diagnosis is delivered, use of the AD label and other terminology, and the level of standardization. The individual consequences include perceptions of patients and depictions of the prognosis. Whether cognitive impairment is viewed as a scientific puzzle to be solved or is seen as a chronic illness significantly shapes the organizational processes of clinical evaluation. Alzheimer's disease, as a cultural object, is a particularly salient exemplar of the clinical negotiation of ambiguous diagnostic categorizations and the unpredictable patient in daily biomedical practice.
Genetics Home Reference: Graves disease

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... Email Facebook Twitter Home Health Conditions Graves disease Graves disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Graves disease is a condition that affects the function of ...
Coal reburning technology for cyclone boilers

International Nuclear Information System (INIS)

Yagiela, A.S.; Maringo, G.J.; Newell, R.J.; Farzan, H.

1990-01-01

Babcock and Wilcox has obtained encouraging results from engineering feasibility and pilot-scale proof-of-concept studies of coal reburning for cyclone boiler NO x control. Accordingly, B and W completed negotiations for a clean coal cooperative agreement with the Department of Energy to demonstrate coal reburning technology for cyclone boilers. The host site for the demonstration is the Wisconsin Power and Light (WP and L) Company's 100MWe Nelson Dewey Station. Reburning involves the injection of a supplemental fuel (natural gas, oil, or coal) into the main furnace to produce locally reducing stoichiometric conditions which convert the NO x produced therein to molecular nitrogen, thereby reducing overall NO x emissions. There are currently no commercially-demonstrated combustion modification techniques for cyclone boilers which reduce NO x emissions. The emerging reburning technology offers cyclone boiler operators a promising alternative to expensive flue gas cleanup techniques for NO x emission reduction. This paper reviews baseline testing results at the Nelson Dewey Station and pilot-scale results simulating Nelson Dewey operation using pulverized coal (PC) as the reburning fuel. Outcomes of the model studies as well as the full-scale demonstration preliminary design are discussed
Acute vs. chronic conditions (image)

Science.gov (United States)

... describe anything from a broken bone to an asthma attack. A chronic condition, by contrast is a long- ... a broken bone, an acute condition. An acute asthma attack occurs in the midst of the chronic disease ...
Patents and Downstream Innovation Suppresion - Facts or Fiction?

DEFF Research Database (Denmark)

Howells, John

of development as aircraft, the car, radio and electric lighting. Merges and Nelson quite logically use their work to question the value of Kitch's prospect theory of patents,[2] a theory that emphasises that the social value of patents is that they enable the coordination of technological development...... and R. Nelson, "On the Complex Economics of Patent Scope," Columbia Law Review 90, no. 4 (1990), R. Merges and R. Nelson, "On Limiting or Encouraging Rivalry in Technical Progress: The Effect of Patent Scope Decisions," Journal of Economic Behavior and Organisation 25 (1994). [2] Merges and Nelson, "On...
Heart disease and diet

Science.gov (United States)

Diet - heart disease; CAD - diet; Coronary artery disease - diet; Coronary heart disease - diet ... diet and lifestyle can reduce your risk of: Heart disease, heart attacks, and stroke Conditions that lead ...

Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions

Directory of Open Access Journals (Sweden)

Yong-Jik Lee

2017-01-01

Full Text Available To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontaneously hypertensive rats (SHRs given high-fat diet. In HepG2 cells and liver tissues, fimasartan was shown to increase the protein levels of peroxisome proliferator-activated receptor delta (PPARδ, phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK, phosphorylated acetyl-CoA carboxylase (p-ACC, malonyl-CoA decarboxylase (MCD, medium chain acyl-CoA dehydrogenase (MCAD, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α, and it led to a decrease in the protein levels of 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSDH1, fatty acid synthase (FAS, and tumor necrosis factor-alpha (TNF-α. Fimasartan decreased lipid contents in HepG2 and differentiated 3T3-L1 cells and liver tissues. In addition, fimasartan increased the adiponectin level in visceral fat tissues. The antiadipogenic effects of fimasartan were offset by PPARδ antagonist (GSK0660. Consequently, fimasartan ameliorates nonalcoholic fatty liver disease mainly through the activation of oxidative metabolism represented by PPARδ-AMPK-PGC-1α pathway.
Factors Affecting Peace Negotiations in Resolving Armed Conflicts in Sub-Saharan Africa

Science.gov (United States)

2011-06-10

the problems of this continent. — Nelson Mandela , former President of South Africa. This chapter analyzes the role of peace negotiations in...of international and regional organizations like the Inter-Governmental Authority on Development (IGAD), influential personalities ( Nelson Mandela ...important lesson for peace negotiations to be successful is summarized by the former President of South Africa, Nelson Mandela , who noted that nobody
Liver disease

Science.gov (United States)

... this page: //medlineplus.gov/ency/article/000205.htm Liver disease To use the sharing features on this page, please enable JavaScript. The term "liver disease" applies to many conditions that stop the ...
Is Photodynamic Therapy with Adjunctive Non-Surgical Periodontal Therapy Effective in the Treatment of Periodontal Disease under Immunocompromised Conditions

International Nuclear Information System (INIS)

Javed, F.; Hezaimi, K.A.; Qadri, T.; Ahmed, H.B.; Corbet, F.E.; Romanos, G.E.

2013-01-01

The aim was to assess whether or not photodynamic therapy (PDT) with adjunctive scaling-and-root-planing (SRP) is effective in the treatment of periodontitis under immunocompromised conditions. PubMed/Medline and Google-Scholar databases were searched from 1967 to May 2013 using various key words. Six studies (five experimental and one clinical) were included. In the clinical study, SRP with PDT was reported to be ineffective in treating chronic periodontitis in T2DM patients. All experimental studies reported significantly less bone loss in periodontal defects treated with SRP+PDT than those treated with SRP alone. Efficacy of PDT+SRP in the treatment of periodontal disease under immunocompromised conditions remains unclear. (author)
Is Photodynamic Therapy with Adjunctive Non-Surgical Periodontal Therapy Effective in the Treatment of Periodontal Disease under Immunocompromised Conditions

Energy Technology Data Exchange (ETDEWEB)

Javed, F.; Hezaimi, K. A. [King Saud Univ., Riyadh (Saudi Arabia). College of Applied Medical Sciences; Qadri, T. [Karolinska Inst., Huddinge (Sweden). Dept. of Dental Medicine; Ahmed, H. B. [Al-Farabi Dental College, Riyadh (Saudi Arabia). Dept. of Dentistry; Corbet, F. E. [University of Hong Kong, Hong Kong (Hong Kong). Dept. of Periodontology; Romanos, G. E. [Stony Brook University, New York (United States). School of Dental Medicine

2013-10-15

The aim was to assess whether or not photodynamic therapy (PDT) with adjunctive scaling-and-root-planing (SRP) is effective in the treatment of periodontitis under immunocompromised conditions. PubMed/Medline and Google-Scholar databases were searched from 1967 to May 2013 using various key words. Six studies (five experimental and one clinical) were included. In the clinical study, SRP with PDT was reported to be ineffective in treating chronic periodontitis in T2DM patients. All experimental studies reported significantly less bone loss in periodontal defects treated with SRP+PDT than those treated with SRP alone. Efficacy of PDT+SRP in the treatment of periodontal disease under immunocompromised conditions remains unclear. (author)
Chronic disease list conditions in patients with rheumatoid arthritis in the private healthcare sector of South Africa.

Science.gov (United States)

Olivier, Nericke; Burger, Johanita; Joubert, Rianda; Lubbe, Martie; Naudé, Adele; Cockeran, Marike

2018-05-01

Little is known about the burden of rheumatoid arthritis (RA) in South Africa. The aim of this study was to establish the prevalence of RA and coexisting chronic disease list (CDL) conditions in the private health sector of South Africa. A retrospective, cross-sectional analysis was performed on medicine claims data from 1 January 2014 to 31 December 2014 to establish the prevalence of RA. The cohort of RA patients was then divided into those with and those without CDL conditions, to determine the number and type of CDL conditions per patient, stratified by age group and gender. A total 4352 (0.5%) patients had RA, of whom 69.3% (3016) presented with CDL conditions. Patients had a median age of 61.31 years (3.38; 98.51), and 74.8% were female. Patients with CDL conditions were older than those patients without (p Gender had no influence on the presence of CDL conditions (p = 0.456). Men had relatively higher odds for hyperlipidemia (OR 1.83; CI 1.33-2.51; p < 0.001) and lower odds for asthma (OR 0.83; CI 0.48-1.42; p = 0.490) than women. In combination with hyperlipidemia, the odds for asthma were reversed and strongly increased (OR 6.74; CI 2.07-21.93; p = 0.002). The odds for men having concomitant hyperlipidemia, hypertension, type 2 diabetes mellitus and hypothyroidism were insignificant and low (OR 0.40; CI 0.16-1.02; p = 0.055); however, in the absence of hypothyroidism, the odds increased to 3.26 (CI 2.25-4.71; p < 0.001). Hypothyroidism was an important discriminating factor for comorbidity in men with RA. This study may contribute to the body of evidence about the burden of RA and coexisting chronic conditions in South Africa.
Symptoms of main Callistephus chinensis L. Nees. diseases under Ukrainian urban ecosystem conditions of the forest-steppe zone

Directory of Open Access Journals (Sweden)

Marchenko Alla

2017-12-01

Full Text Available Phytopathological monitoring of C. chinensis (L. Nees. has proven withering and root rot to be the dominating diseases in agrobiocenoses under Ukrainian urban ecosystem conditions of the forest-steppe zone. Their spread was 5,1 and 4 times more than one of spotting. The complex of plant pathogenic overground and underground microflora consists of 24 causative agents. B. cinerea, F. oxysporum, V. albo-atrum have been found on all the vegetative and reproductive parts of Callistephus chinensis (L. Nees., , Ph. cactorum – on plant overground and underground parts, Rh. solani – on underground parts and seeds, A. zinniae – on overground parts and seeds. The main C. chinensis (L. Nees. disease symptoms have been diagnosed (leaf spots, powdery mildew, verticillium wilt, rust, ramularia spot, septoria spots, botrytis blight, grey mold rot, late blight, fusarium blight, black stem.
Association between periodontal diseases and systemic diseases

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Patrícia Weidlich

2008-08-01

Full Text Available Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Brazilians (3 concerning cardiovascular disease, 7 about pregnancy outcomes, 9 about diabetes and one regarding pneumonia. Although the majority of them observed an association between periodontitis and systemic conditions, a causal relationship still needs to be demonstrated. Further studies, particularly interventional well-designed investigations, with larger sample sizes, need to be conducted in Brazilian populations.
Dance for the rehabilitation of balance and gait in adults with neurological conditions other than Parkinson's disease: A systematic review

Directory of Open Access Journals (Sweden)

Kara K. Patterson

2018-03-01

Full Text Available Purpose: To conduct a systematic review that examined the effect of dance interventions on balance, gait and functional mobility outcomes in adults with neurological conditions other than Parkinson's disease. Methods: A systematic search of relevant databases was conducted. Data extraction and methodological appraisal were performed by two independent authors. Results: Nine studies were included (4 pre-post studies with no control group, 3 case reports, and 2 controlled studies and results of the methodological quality assessment ranged from poor to good. Study groups included stroke, multiple sclerosis, spinal cord injury, and Huntington's disease. Dance interventions varied in frequency, type and duration, and only 1 study reported intensity. Study dropout rates ranged from 20–44%, and 88–100% of dance classes were attended. Only 3 studies mentioned adverse events, of which there were none. A summary of results revealed significant changes in spatiotemporal gait parameters, Berg Balance Scale scores, Timed Up and Go test and six-minute walk test that were similar to or greater than those previously reported in a review of dance for individuals with Parkinson's disease. Conclusions: There is emerging evidence to support the use of dance as a feasible intervention for adults with neurological conditions. Further investigation of the effects of dance with randomized controlled trials using larger sample sizes and better reporting of the intervention, participant tolerance, and adverse events is warranted. Keyword: Rehabilitation
Heart disease - risk factors

Science.gov (United States)

Heart disease - prevention; CVD - risk factors; Cardiovascular disease - risk factors; Coronary artery disease - risk factors; CAD - risk ... a certain health condition. Some risk factors for heart disease you cannot change, but some you can. ...
Iconography and Politics in South Africa: the representation of Nelson Mandela, Thabo Mbeki and Jacob Zuma in cartoons of Zapiro

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Renata de Paula dos Santos

2014-12-01

Full Text Available Mandela’s victory in the 1994 elections in South Africa is a reference point for South African history and represented the transition from apartheid to multiracial democracy. Since then Nelson Mandela (1994-1999, Thabo Mbeki (1999-2008 and Jacob Zuma (2009 - current, occupied the post of president of the country and led, each in its own way, the new direction of the country. During the nearly twenty years of multiracial democracy, one in particular cartoonist, Jonathan Shapiro, popularly known by the pseudonym Zapiro, portrayed the everyday life of this story. In this sense, the objective of this research is to analyze how Zapiro portrayed the political and social aspects, as well as the psychological characteristics of each of the three postapartheid presidents and which social representations are formed from their cartoon production. The choice of Zapiro explained by openly declared his opposition to apartheid and also for being the best known outside South African cartoonist. We elected to cartoon as an object of study because it is an iconographic object constituted by communicative humor, which adds to its constitution arguments transgression of the established order, enabling an analysis of South African history through a critical bias. As methods for the development of the work, we decided to gather historical research, the literature search and analysis of cartooon speech. Among the theoretical frameworks stand out Magnoli (1998, 2009, Jonge (1991 and Carlin (2009 in the South African question; reflections about social representations, we resort to Moscovici (2011 and Jodelet (1993, in the field the cartoon and humor, the references are Miani (2005; 2012, Romualdo (2000 and Eco (1989. With the completion of the analysis, we observed that Zapiro acts in different ways in the construction of the representation of each of the presidents in question and that the cartoonist presents Mandela as a competent leader marked by heroism and
Undifferentiated Connective Tissue Disease

Science.gov (United States)

... Home Conditions Undifferentiated Connective Tissue Disease (UCTD) Undifferentiated Connective Tissue Disease (UCTD) Make an Appointment Find a Doctor ... by Barbara Goldstein, MD (February 01, 2016) Undifferentiated connective tissue disease (UCTD) is a systemic autoimmune disease. This ...
Author Details

African Journals Online (AJOL)

Nelson, GK. Vol 47, No 3 (1973) - Articles Neuropsychological Research Approaches in the Epilepsies Abstract PDF. ISSN: 0256-95749. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...
Author Details

African Journals Online (AJOL)

Ukwamedua, Nelson Udoka. Vol 17, No 3 (2017) - Articles Philosophy and African Philosophy: A Conceptual Analysis Abstract PDF. ISSN: 1595-1413. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...
GESTÃO INOVADORA DE PROJETOS E ESTUDO DE CASO DE CONTROLE DE EMPREENDIMENTO: NELSON MANDELA BAY METROPOLE – ÁFRICA DO SUL

Directory of Open Access Journals (Sweden)

Daniel De Witt Koen

2010-12-01

Full Text Available Uma pesquisa Intensiva com os usuários finais no setor da Habitação Econômica da República Sul-Africana tornou-se necessário para encontrar formas de enfrentar o contínuo aumento dos custos e ainda continuar a satisfazer as preferências, com qualidade e acessibilidade. A pesquisa tem de ser sucedida por projetos inovadores e métodos construtivos rápidos e de baixo custo, sem perder qualidade e estética. Os custos de terreno e o adensamento dos projetos, em equilíbrio com a qualidade ambiental, tornaram-se de enorme importância em qualquer empreendimento sustentável. O mesmo se aplica às vizinhanças, quanto à revitalização dos bairros. Um exemplo típico é o Nelson Mandela Bay Metropole na África do Sul, onde 100.000 unidades habitacionais precisam ser construídas em um período de três a cinco anos para acabar com o déficit. A quantidade de dados relativos a uma única habitação é vasta e, em um grande empreendimento, ainda mais significativa. Tradicionalmente, os dados são armazenados em vários locais, por exemplo, com autoridades governamentais, arquitetos ou outros profissionais, empreendedores, subcontratados, agentes imobiliários, instituições financeiras ou proprietários. Baixa eficiência e atrasos substanciais são o resultado, quando os dados existentes não podem ser acessados rapidamente, ou não são encontrados. Um processo de localização espacial e sistema de controle de dados física e inequivocamente associado com cada particular unidade habitacional foi desenvolvido para resolver com sucesso a maioria desses problemas.
Congenital cardiac disease in childhood x socioeconomic conditions: a relationship to be considered in public health?

Directory of Open Access Journals (Sweden)

Thayanny Lopes do Vale Barros

2014-09-01

Full Text Available Introduction: Congenital heart defects, cardiac malformations that occur in the embryonic period, constitute a serious health problem. They cover a proportion of 8-10 per 1000 live births and contribute to infant mortality. Objective: To identify the socioeconomic status of children undergoing cardiac surgery at the Hospital Universitário da Universidade Federal do Maranhão, in São Luis, the existence of material elements that contribute to worsening conditions. Methods: We conducted a retrospective study with a quantitative approach, descriptive and reflective, from the interviews conducted by the Social Service Social with families of children with heart disease from January 2011 to July 2012. Results: A total of 95 interviews, the results reveal that (75.79% of children have elements that suggest poor socioeconomic conditions. It also shows that only 66.33% lived in brick house, while (31.73% in mud, adobe and straw houses. With regard to income, it showed that only 4.08% received 1-2 minimum wages, while the remaining (95.9% with benchmarks oscillating half the minimum wage (27.55%, 1/4 of the minimum wage and (24.48% and income below 70 dollars per person, featuring extreme poverty. On the social security situation prevailing at children with no ties to 61.22%. With respect to benefits, we found that only (12.24% of children were in the enjoyment of the Continuous Cash Benefit - CCB. Conclusion: Poor socioeconomic conditions listed as major obstacles in meeting the needs, resulting in the maintenance of health conditions and even allowing the aggravation of an existing pathology.
Kidney Disease

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Kidney Disease KidsHealth / For Teens / Kidney Disease What's in ... Coping With Kidney Conditions Print What Do the Kidneys Do? You might never think much about some ...
76 FR 14600 - Dental Conditions

Science.gov (United States)

2011-03-17

... qualify for VHA dental treatment, including any claim for treatment of periodontal disease or calculus... DEPARTMENT OF VETERANS AFFAIRS 38 CFR Part 3 RIN 2900-AN28 Dental Conditions AGENCY: Department of... its adjudication regulations regarding service connection of dental conditions for treatment purposes...
Nelson Rodrigues escribe como mujer Nelson Rodrigues writing as a woman

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Cecilia Inés Luque

2012-06-01

Full Text Available Rodrigues firmó el melodrama autobiográfico Minha Vida con el heterónimo Suzana Flag. La autoría enmascarada y la enunciación travestida de este texto naturalizan los efectos ideológicos de la historia de amor, pero también plantean -tal vez inintencionalmente- una crítica al proceso de subjetivación femenina implícito en ella y una parodia al resultante ideal de Mujer. El análisis de las características contradictorias de este texto ponen en evidencia las limitaciones de la categoría "literatura de mujeres", y señala la pertinencia de remplazarla con la de "escribir como mujer".Rodrigues signed his heteronym's name - Suzana Flag- on the autobiographical melodrama Minha Vida [My Life]. The masked authorship and the transvestite enunciation of this text naturalize the ideological effects of the love story, but also poses -perhaps unintentionally- a critical view of the related process of producing a feminine subjectivity and a parody of the resulting ideal of Woman. The analysis of the contradictory characteristics of this text reveals the limitations of the category of "women's literature" and suggests the pertinence of replacing it with that of "writing like (or as a woman".
Dynamic Regression Model for Evaluating the Association Between Atmospheric Conditions and Deaths due to Respiratory Diseases in São Paulo, Brazil

Directory of Open Access Journals (Sweden)

Ana Carla dos Santos Gomes

Full Text Available Abstract The article reports the modeling of mortality due to respiratory diseases emanating from atmospheric conditions, capturing significant associations and verifying the ability of stochastic modeling to predict deaths arising from the relationship between weather conditions and air pollution. The statistical methods used in the analysis were cross-correlation and pre-whitening, in addition to dynamic regression modeling combining the dynamics of time series and the effect of explanatory variables. The results show there are significant associations between mortality and sulfur dioxide, air temperature, atmospheric pressure, relative humidity, and autoregressive structure. The cross-correlations captured significant lags between atmospheric variables and deaths, of two months for SO2 and relative humidity, eleven months for PM10, seven months for O3, and eight months for air temperature and the cross-correlation without lag with NO2. With CO variables, precipitation and atmospheric pressure, cross-correlations were not detected. Stochastic modeling showed that deaths due to respiratory diseases can be predicted from the combination of meteorological and air pollution variables, especially considering the existing trend and seasonality.

Defining and Measuring Chronic Conditions

Centers for Disease Control (CDC) Podcasts

2013-05-20

This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States. Created: 5/20/2013 by Preventing Chronic Disease (PCD), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP). Date Released: 5/20/2013.
On Death Ground: Why Weak States Resist Great Powers Explaining Coercion Failure in Asymmetric Interstate Conflict

Science.gov (United States)

2010-09-01

After mediation by UN Secretary-General Kofi Annan and South African President Nelson Mandela , however, Qadhafi finally handed the two suspects over...if the two accused were not handed over the U.S.-Britain would seek tougher sanctions. During a visit by Nelson Mandela on 19 March 1999 Qadhafi...potential commitment issues by involving UN Secretary General Kofi Annan and South African President Nelson Mandela in the final talks. This success
South Africa: Current Issues and U.S. Relations

Science.gov (United States)

2009-05-20

almost 900 soldiers to the U.N. Operation in Burundi (ONUB), where former President Nelson Mandela played a leading role in brokering a peace...racial segregation, won control of the National Assembly. The Assembly chose as President Nelson Mandela , the ANC leader who had been released from...reportedly improving. South Africa has taken a critical stance toward the war in Iraq, and former President Nelson Mandela has been vocal in his
Hybrid War Beyond Lebanon: Lessons from the South African Campaign 1976 to 1989

Science.gov (United States)

2009-05-01

transitioned to majority rule under the ANC and President Nelson Mandela . 69 The South Africans had achieved their military objectives in both Angola and...downplayed their own losses. Nelson Mandela later remarked that, ― The decisive defeat of the racist army in Cuito Canavalle was a...112 Nelson Mandela , Address at the Cuban National Cuba, July 26 1991.http://lanic.utexas.edu /project/castro/db/1991/ 19910726-1.html. He
The Enduring Grand Strategy of the United States Represented as a Mirror Strategy

Science.gov (United States)

2016-04-06

Development Council regime.43 On 27 April 1994 in South Africa, Nelson Mandela won 62% of the votes in the popular election, that overthrew the apartheid...news/ nelson - mandelas -journey-from-prisoner-to-president/ (accessed 16 December 2015) 45 Brainy History, “1982 in History,” http...December 7, 2013, 9:50 PM http://www.cbsnews.com/news/ nelson - mandelas -journey-from-prisoner-to- president/ (accessed 16 December 2015) cornell.edu
Cold Weather and Cardiovascular Disease

Science.gov (United States)

... Venous Thromboembolism Aortic Aneurysm More Cold Weather and Cardiovascular Disease Updated:Sep 16,2015 Th is winter ... and procedures related to heart disease and stroke. Cardiovascular Conditions • Conditions Home • Arrhythmia and Atrial Fibrillation • Cardiac ...
Optimization of Enzymatic Hydrolysis of Waste Bread before Fermentation

OpenAIRE

Hudečková, Helena; Šupinová, Petra; Ing. Mgr. Libor Babák, Ph.D., MBA

2017-01-01

Finding of optimal hydrolysis conditions is important for increasing the yield of saccharides. The higher yield of saccharides is usable for increase of the following fermentation effectivity. In this study optimal conditions (pH and temperature) for amylolytic enzymes were searched. As raw material was used waste bread. Two analytical methods for analysis were used. Efficiency and process of hydrolysis was analysed spectrophotometrically by Somogyi-Nelson method. Final yields of glucose were...
Periodontal disease and women's health.

Science.gov (United States)

Martelli, Maria Luisa; Brandi, Maria Luisa; Martelli, Marialaura; Nobili, Piero; Medico, Enzo; Martelli, Francesco

2017-06-01

Periodontal disease (PD) is a multifactorial inflammatory condition in which inappropriate interaction between the host immune response and specific groups of bacterial pathogens leads to destruction of connective and bone tissues supporting the tooth. Dissemination of pathogens, toxins, and immune complexes from and to periodontal lesions is at the basis of the increasingly recognized association between PD and various systemic diseases (SDs). Considering the growing attention of the medical community to "gender medicine", this review focuses on the association between PD and six systemic conditions heavily impacting women's health, with the aim of providing evidence in support of a joint effort between physicians and dentists to improve clinical management of these conditions. We considered systematic reviews, meta-analyses and narrative reviews evaluating all possible associations between periodontitis, systemic diseases and women. Gender prevalence for PD is discordant, but the literature strongly supports an association between PD and female infertility and adverse pregnancy outcomes. Moreover, PD is bidirectionally linked to several systemic diseases characterized by an established female gender bias, i.e. osteoporosis (OP), cardiovascular diseases (CVD), autoimmunity, Alzheimer's disease (AD) and cancer. Overall, the literature data reviewed here provides a strong foundation for further characterization of molecular and microbial drivers of PD and of several female-prevalent systemic diseases, highlighting the possible importance of a good oral condition in preventing or attenuating women's systemic diseases.
Role of pulmonary diseases and physical condition in the regulation of vasoactive hormones.

Science.gov (United States)

Hietanen, E; Marniemi, J; Liippo, K; Seppänen, A; Hartiala, J; Viinamäki, O

1988-12-01

Lungs have many non-respiratory metabolic functions, of which some take place in the capillary endothelium, while others are in parenchymal lung tissue. We have studied the role of the lungs in the metabolism of vasoactive and some other hormones by comparing patients who have undergone lung resection to those having various obstructive or fibrotic lung diseases. We have also compared these groups with persons in good physical health. The data suggested that lung resection patients had low angiotensin II levels in plasma but the response of angiotensin II to exercise was normal. Also adrenalin concentration was low in the lung resection group while dopamine did not show any significant difference between the groups. When hormone levels were correlated to the exercise data, renin levels were especially related to physical condition. Serum post-exercise renin values were inversely related to the uneven distribution of lung perfusion, possibly thus reflecting the diminished pulmonary vascularization. A negative association was found between angiotensin II and diffusion capacity. Thus, the angiotensin II levels may preferably be controlled by the non-circulatory functions of the lungs.
Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia

DEFF Research Database (Denmark)

Baron, F; Labopin, M; Niederwieser, D

2012-01-01

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). Grade I acute GVHD was associated with a lower risk...... of relapse (hazards ratio (HR)=0.7, P=0.02) translating into a trend for better overall survival (OS; HR=1.3; P=0.07). Grade II acute GVHD had no net impact on OS, while grade III-IV acute GVHD was associated with a worse OS (HR=0.4, P...
Coronary artery disease in patients with cerebrovascular disease: a prospective study

International Nuclear Information System (INIS)

Rokey, R.; Rolak, L.A.; Harati, Y.; Kutka, N.; Verani, M.S.

1984-01-01

Coronary artery disease is the cause of death in most patients who have transient ischemic attacks or stroke. Evaluation for this condition is not routinely performed in such patients, and no prospective studies have been reported. We prospectively examined 50 consecutive patients with transient ischemic attacks or mild stroke to determine the prevalence and importance of coronary artery disease. All patients were examined by a cardiologist and underwent both exercise thallium-201 scintigraphy and exercise radionuclide ventriculography. Sixteen patients were suspected to have coronary artery disease on the basis of clinical evaluation. In 15 of these the was confirmed by the nuclear scans. The remaining 34 patients had no clinical evidence of heart disease, yet 14 had abnormal cardiac scans. Twenty of 22 patients with abnormal scans who underwent cardiac catheterization had significant coronary artery disease or a cardiomyopathy. The discovery of heart disease altered clinical management in 13 patients. Overall, 29 of 50 patients had significant coronary artery disease, compared with a 7% prevalence of the condition in other patients of similar age at the same institution
Desbotone en diferentes estadios de desarrollo del botón floral en clavel estándar (Dianthus caryophyllus L. var. Nelson

Directory of Open Access Journals (Sweden)

Arévalo Gabriel Alexander

2007-06-01

Full Text Available
Los mayores costos de producción del clavel estándar se asocian con la mano de obra que se utiliza en las labores del cultivo; el desbotone es una de las actividades que demanda mayor uso de mano de obra y tiempo. El objetivo del estudio fue determinar el efecto del desbotone en diferentes estadios de desarrollo del botón principal, sobre la producción y calidad en poscosecha del clavel estándar variedad Nelson en el primer pico de cosecha. Se evaluaron los estadios conocidos popularmente como botón ‘arveja’, ‘garbanzo’, ‘barril’, ‘estrella’, ‘bala’ y ‘punto de corte’. Las variables medidas incluyeron producción total a primera cosecha, grados de calidad y algunos criterios de clasificación en poscosecha. Se concluyó que el desbotone en los estadios evaluados no influye significativamente en la producción total del clavel en la primera cosecha. Sin embargo, en la clasificación por grados de calidad, se encontraron diferencias significativas: el desbotone en botón arveja’, ‘garbanzo’ y ‘barril’ mostró mayores promedios en el número de tallos grado ‘select’, mientras que el desbotone en botón ‘estrella’, ‘bala’ y ‘punto de corte’ reflejó mayores promedios para los grados ‘fancy’ estándar y nacional. El desbotone en diferentes estadios de desarrollo del botón principal afectó el número de tallos torcidos, sin aumentar significativamente el número de tallos débiles. El ensayo permitió definir que la etapa crítica para el desbotone son los estadios de desarrollo del botón principal previos al estadio ‘barril’, pues pasado este punto disminuye la calidad del producto.
Genetics Home Reference: Alzheimer disease

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... Email Facebook Twitter Home Health Conditions Alzheimer disease Alzheimer disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Alzheimer disease is a degenerative disease of the brain ...
Stochastic spin-one massive field

International Nuclear Information System (INIS)

Lim, S.C.

1984-01-01

Stochastic quantization schemes of Nelson and Parisi and Wu are applied to a spin-one massive field. Unlike the scalar case Nelson's stochastic spin-one massive field cannot be identified with the corresponding euclidean field even if the fourth component of the euclidean coordinate is taken as equal to the real physical time. In the Parisi-Wu quantization scheme the stochastic Proca vector field has a similar property as the scalar field; which has an asymptotically stationary part and a transient part. The large equal-time limit of the expectation values of the stochastic Proca field are equal to the expectation values of the corresponding euclidean field. In the Stueckelberg formalism the Parisi-Wu scheme gives rise to a stochastic vector field which differs from the massless gauge field in that the gauge cannot be fixed by the choice of boundary condition. (orig.)
LONG-TERM OUTCOME OF THE DIFFERENT TREATMENT ALTERNATIVES FOR RECURRENT AND PERSISTENT CUSHING DISEASE.

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Espinosa-de-Los-Monteros, Ana Laura; Sosa-Eroza, Ernesto; Espinosa, Etual; Mendoza, Victoria; Arreola, Rocio; Mercado, Moises

2017-07-01

Treatment alternatives for persistent and recurrent Cushing disease (CD) include pituitary surgical re-intervention, radiation therapy (RT), pharmacotherapy, and bilateral adrenalectomy (BA). The decision of which of these alternatives is better suited for the individual patient rests on clinical judgment and the availability of resources. This retrospective cohort study was performed at a referral center to evaluate the long-term efficacy of different secondary interventions for persistent and recurrent CD. We evaluated the hospital charts of 84 patients (77 female, median age 34 years, median follow up 6.3 years) with CD diagnosed, treated, and followed at our multidisciplinary clinic according to a pre-established protocol. Of the 81 patients who were initially treated with transsphenoidal surgery (TSS), 61.7% had a long-lasting remission, 16% had persistent disease, and 22% achieved remission but relapsed during follow-up. The most frequently used secondary treatment was pituitary re-intervention, followed by ketoconazole, RT, and BA. Early remissions were observed in 66.6% of the re-operated and in 58.3% of the radiated patients; long-lasting remission was achieved in 33.3% and 41.6% of these patients, respectively. Nelson syndrome developed in 41.6% of the patients who underwent BA. Upon last follow-up, 88% of all the patients are in remission, and 9.5% are biochemically controlled with ketoconazole. The efficacy of treatment alternatives for recurrent or persistent CD varies considerably among patients and multiple interventions are often required to achieve long-lasting remission. ACTH = adrenocorticotrophic hormone; BA = bilateral adrenalectomy; CBG = cabergoline; CD = Cushing disease; CV = coefficient of variation; DXM = dexamethasone; IQR = interquartile range; RT = radiation therapy; SRS = stereotactic radiosurgery; TSS = transsphenoidal surgery; UFC = urinary free cortisol; ULN = upper limit of normal.
Prospect of stem cell conditioned medium in regenerative medicine.

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Pawitan, Jeanne Adiwinata

2014-01-01

Stem cell-derived conditioned medium has a promising prospect to be produced as pharmaceuticals for regenerative medicine. To investigate various methods to obtain stem cell-derived conditioned medium (CM) to get an insight into their prospect of application in various diseases. Systematic review using keywords "stem cell" and "conditioned medium" or "secretome" and "therapy." Data concerning treated conditions/diseases, type of cell that was cultured, medium and supplements to culture the cells, culture condition, CM processing, growth factors and other secretions that were analyzed, method of application, and outcome were noted, grouped, tabulated, and analyzed. Most of CM using studies showed good results. However, the various CM, even when they were derived from the same kind of cells, were produced by different condition, that is, from different passage, culture medium, and culture condition. The growth factor yields of the various types of cells were available in some studies, and the cell number that was needed to produce CM for one application could be computed. Various stem cell-derived conditioned media were tested on various diseases and mostly showed good results. However, standardized methods of production and validations of their use need to be conducted.
Common Childhood Orthopedic Conditions

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... Parents Parents site Sitio para padres General Health Growth & Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & ... pain. Toe Walking Toe walking is common among toddlers as they learn to walk, especially during the ...
How Can the United States Counter China’s Growing Influence in Africa through Non-kinetic Means?

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2011-03-21

summer of 1995 at the Rugby World Cup when Springbok Captain, Franc;:ois Pienaar raised the Webb Ellis Cup standing next to President Nelson Mandela of...Africa." (Journal of Chinese Political Science, 2009, 14). 10 124 John Carlin. Playing The Enemy, Nelson Mandela and the Game that Made a Nation...South Africa. I did not understand the significance of this event until I read John Carlin’s book Playing the Enemy. President Nelson Maridela used
Fatty Liver Disease

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What is fatty liver disease? Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Fatty liver disease is a condition in which fat builds ...
Computed tomography in Alexander's disease

Energy Technology Data Exchange (ETDEWEB)

Holland, I M; Kendall, B E

1980-10-01

Two cases of biopsy-proven Alexander's disease are described with computed tomographic changes which, in our experience and on survey of the literature, have not occurred in any other condition. Such changes in a child with a progressive condition consistent with Alexander's disease, strongly support the diagnosis.

Leading curriculum change: Reflections on how Abakhwezeli stoked ...

African Journals Online (AJOL)

Delport, Aletta (Prof) (Summerstrand Campus South)

2016-11-24

Nov 24, 2016 ... School for Initial Teacher Education, Faculty of Education, Nelson Mandela Metropolitan University ... 'Abakhwezeli', in stoking the fires of curriculum change in the Nelson Mandela ...... NY: Continuum International Publishing.
Systemic isotretinoin in the management of acne – a patient ...

African Journals Online (AJOL)

2008-11-13

Nov 13, 2008 ... towards the inhibition of the multiple pathogenic processes underlying ... b Department of Statistics, Nelson Mandela Metropolitan University, South ..... the Nelson Mandela Metropolitan University for the financial support of.
Thymic hyperplasia in Graves′ disease

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Narendra Kotwal

2013-01-01

Full Text Available Graves′ disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. It is known to be associated with autoimmune conditions such as myasthenia gravis, Addison′s disease, type 1 diabetes mellitus, and vitiligo. We present a case of rare autoimmune association of Graves′ disease with thymic hyperplasia which regressed after treatment with antithyroid drugs. Exact pathophysiology of thymic hyperplasia in Graves′ is not well understood; it is likely to be the result of rather than the cause of Graves′ disease.
Purification and characterization of extracellular amylolytic enzyme ...

African Journals Online (AJOL)

DOSS

2012-10-16

Oct 16, 2012 ... Available online at http://www.academicjournals.org/AJB ... characterization of extracellular amylases from four ... Somogyi-Nelson's method (Nelson, 1944; Somogyi, 1952). ... The mycelia dry weight of currently studied four.
Hospital care for mental health and substance abuse conditions in Parkinson's disease.

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Willis, Allison W; Thibault, Dylan P; Schmidt, Peter N; Dorsey, E Ray; Weintraub, Daniel

2016-12-01

The objective of this study was to examine mental health conditions among hospitalized individuals with Parkinson's disease in the United States. This was a serial cross-sectional study of hospitalizations of individuals aged ≥60 identified in the Nationwide Inpatient Sample dataset from 2000 to 2010. We identified all hospitalizations with a diagnosis of PD, alcohol abuse, anxiety, bipolar disorder, depression, impulse control disorders, mania, psychosis, substance abuse, and attempted suicide/suicidal ideation. National estimates of each mental health condition were compared between hospitalized individuals with and without PD. Hierarchical logistic regression models determined which inpatient mental health diagnoses were associated with PD, adjusting for demographic, payer, geographic, and hospital characteristics. We identified 3,918,703 mental health and substance abuse hospitalizations. Of these, 2.8% (n = 104, 437) involved a person also diagnosed with PD. The majority of mental health and substance abuse patients were white (86.9% of PD vs 83.3% of non-PD). Women were more common than men in both groups (male:female prevalence ratio, PD: 0.78, 0.78-0.79, non-PD: 0.58, 0.57-0.58). Depression (adjusted odds ratio 1.32, 1.31-1.34), psychosis (adjusted odds ratio 1.25, 1.15-1.33), bipolar disorder (adjusted odds ratio 2.74, 2.69-2.79), impulse control disorders (adjusted odds ratio 1.51, 1.31-1.75), and mania (adjusted odds ratio 1.43, 1.18-1.74) were more likely among PD patients, alcohol abuse was less likely (adjusted odds ratio 0.26, 0.25-0.27). We found no PD-associated difference in suicide-related care. PD patients have unique patterns of acute care for mental health and substance abuse. Research is needed to guide PD treatment in individuals with pre-existing psychiatric illnesses, determine cross provider reliability of psychiatric diagnoses in PD patients, and inform efforts to improve psychiatric outcomes. © 2016 International Parkinson and
Capacity and willingness of patients with chronic noncommunicable diseases to use information technology to help manage their condition: a cross-sectional study.

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Afshar, Arash Ehteshami; Weaver, Robert G; Lin, Meng; Allan, Michael; Ronksley, Paul E; Sanmartin, Claudia; Lewanczuk, Richard; Rosenberg, Mark; Manns, Braden; Hemmelgarn, Brenda; Tonelli, Marcello

2014-04-01

Health care providers have shown considerable interest in using information technologies such as email, text messages and video conferencing to facilitate the management of chronic noncommunicable diseases such as hypertension, diabetes mellitus and vascular disease. We sought to determine whether these technologies are available and appealing to the target population. We analyzed cross-sectional data from a computer-assisted telephone survey, conducted by Statistics Canada in February and March 2012, of western Canadian adults with at least 1 chronic condition. Survey respondents were asked about their capacity (e.g., "Do you own a mobile phone?") and willingness to use each of 3 information technologies (email, text messages and video conferencing) to interact with health care providers. For all analyses, Statistics Canada's calibrated design weights and bootstrap weights were used to obtain population-level point estimates for proportions and odds ratios. In total, 1849 (79.8%) of 2316 eligible people participated. Of the 1849 participants, 81.9% had hypertension, 26.2% had diabetes, 21.4% had heart disease, and 7.9% had stroke; 32.2% had more than 1 of the 4 chronic conditions of interest. High proportions of respondents owned a computer with Internet access (76.4%, 95% confidence interval [CI] 73.3%-79.3%) or a mobile phone (73.9%, 95% CI 70.7%-76.8%). About two-thirds of respondents were interested in using email to interact with a specialist (66.3%, 95% CI 63.0%-69.5%); respondents were less enthusiastic about using text messages (44.9%, 95% CI 41.2%-48.7%). Enthusiasm for video conferencing was more pronounced among those residing further from medical specialists than among those living closer. Among respondents who were potentially interested in video conferencing, almost 50% of remote dwellers would use this technology if it saved more than 60 minutes of travel time. Many people were interested in using electronic technologies, especially video
Evaluation of Probabilistic Disease Forecasts.

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Hughes, Gareth; Burnett, Fiona J

2017-10-01

The statistical evaluation of probabilistic disease forecasts often involves calculation of metrics defined conditionally on disease status, such as sensitivity and specificity. However, for the purpose of disease management decision making, metrics defined conditionally on the result of the forecast-predictive values-are also important, although less frequently reported. In this context, the application of scoring rules in the evaluation of probabilistic disease forecasts is discussed. An index of separation with application in the evaluation of probabilistic disease forecasts, described in the clinical literature, is also considered and its relation to scoring rules illustrated. Scoring rules provide a principled basis for the evaluation of probabilistic forecasts used in plant disease management. In particular, the decomposition of scoring rules into interpretable components is an advantageous feature of their application in the evaluation of disease forecasts.
Dermatological diseases in patients with chronic kidney disease.

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Gagnon1, Amy L; Desai, Tejas

2013-04-01

There are a variety of dermatological diseases that are more commonly seen in patients with chronic kidney disease (CKD) and renal transplants than the general population. Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science has been searched. Some cutaneous diseases are clearly unique to this population. Of them, Lindsay's Nails, xerosis cutis, dryness of the skin, nephrogenic systemic fibrosis and acquired perforating dermatosis have been described in chronic kidney disease patients. The most common malignancy found in all transplant recipients is non-melanoma skin cancer. It is important for patients and physicians to recognize the manifestations of skin disease in patients suffering from chronic kidney disease to mitigate the morbidity associated with these conditions.
Nonalcoholic Fatty Liver Disease & NASH

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... Eating, Diet, & Nutrition Clinical Trials Wilson Disease Nonalcoholic Fatty Liver Disease & NASH View or Print All Sections Definition & Facts Nonalcoholic fatty liver disease (NAFLD) is a condition in which fat ...
Symptoms of Celiac Disease

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... tested for celiac disease and if negative the test should be repeated on a periodic basis. These conditions include insulin-dependent diabetes mellitus (requiring insulin therapy), Hashimoto’s thyroiditis, Turner’s syndrome, Williams syndrome, Graves disease and Sjogren’s disease. what turns ...
75 FR 69151 - Small Business Jobs Act: 504 Loan Program Debt Refinancing

Science.gov (United States)

2010-11-10

... meeting is open to the public; however, seating is limited so advance notice of attendance is requested... Robert Nelson, District Director, at (617) 565-5561, e-mail: robert.nelson@sba.gov , SBA, Massachusetts...
SCINTIGRAPHY IN URGENT CONDITIONS AND COMPLICATIONS OF ACUTE DISEASES AND TRAUMAS

Directory of Open Access Journals (Sweden)

N. Ye. Kudryashova

2014-01-01

Full Text Available ABSTRACT. The data generalized in the review characterize radionuclide method as a high informative technique in diagnosis of the row of acute diseases and traumas and complications of them. It was shown that each radionuclide technique decides the concrete clinical tests and has a strictly definite place in the diagnostic algorithm. Urgent radionuclide techniques give the important information for the choice of the treatment’s policy or operation’s volume in such acute diseases as tromboembolism, arterial occlusions, small bowel obstruction, acute cholecystitis and cholelithiasis, acute myocardial infarct, rhabdomyolysis, differentiation of acute urological and acute abdominal surgical diseases and so on. The main aim of the work of our radionuclide department is to perfect, modificate of urgent radionuclide techniques and to correct the place of them in urgent conditions’s diagnostic algorithm for increasing of the quality and the rapidity in diagnosis.
Sickle Cell Disease (For Parents)

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... Safe Videos for Educators Search English Español Sickle Cell Disease KidsHealth / For Parents / Sickle Cell Disease What's ... español Enfermedad de células falciformes What Is Sickle Cell Disease? Sickle cell disease is a condition in ...
Public support for neonatal screening for Pompe disease, a broad-phenotype condition

NARCIS (Netherlands)

Weinreich, S.S.; Rigter, T.; van El, C.G.; Dondorp, W.J.; Kostense, P.J.; van der Ploeg, A.T.; Reuser, A.J.; Cornel, M.C.; Hagemans, M.L.

2012-01-01

Background: Neonatal screening for Pompe disease has been introduced in Taiwan and a few U.S. states, while other jurisdictions including some European countries are piloting or considering this screening. First-tier screening flags both classic infantile and late-onset Pompe disease, which
Clinical conditions associated withintestinal strongyloidiasis in Rio de Janeiro, Brazil

Directory of Open Access Journals (Sweden)

Anna Caryna Cabral

2015-06-01

Full Text Available INTRODUCTION: Strongyloides stercoralis is a soil-transmitted helminth that produces an infection that can persist for decades. The relationships between certain clinical conditions and strongyloidiasis remains controversial. This study aims to identify the clinical conditions associated with intestinal strongyloidiasis at a reference center for infectious diseases in Rio de Janeiro, Brazil. METHODS: The clinical conditions that were assessed included HIV/AIDS, HTLV infection, cardiovascular diseases, diabetes, obstructive respiratory diseases, viral hepatitis, tuberculosis, cancer, chronic renal disease, nutritional/metabolic disorders, psychiatric conditions, rheumatic diseases and dermatologic diseases. We compared 167 S. stercoralis-positive and 133 S. stercoralis-negative patients. RESULTS: After controlling for sex (male/female OR = 2.29; 95% (CI: (1.42 - 3.70, rheumatic diseases remained significantly associated with intestinal strongyloidiasis (OR: 4.96; 95% CI: 1.34-18.37 in a multiple logistic regression model. With respect to leukocyte counts, patients with strongyloidiasis presented with significantly higher relative eosinophil (10.32% ± 7.2 vs. 4.23% ± 2.92 and monocyte (8.49% ± 7.25 vs. 5.39% ± 4.31 counts and lower segmented neutrophil (52.85% ± 15.31 vs. 61.32% ± 11.4 and lymphocyte counts (28.11% ± 9.72 vs. 30.90% ± 9.51 than S. stercoralis-negative patients. CONCLUSIONS: Strongyloidiasis should be routinely investigated in hospitalized patients with complex conditions facilitate the treatment of patients who will undergo immunosuppressive therapy. Diagnoses should be determined through the use of appropriate parasitological methods, such as the Baermann-Moraes technique.
Gastroesophageal reflux disease and non-digestive tract diseases.

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Chen, Ying

2015-05-01

Over the past decade, incidence of gastroesophageal reflux disease (GERD) showed an increasing trend resulting from factors, including lifestyle and dietary habits; however, both etiology and pathological mechanisms remain controversial. GERD occurs as a result of a variety of mechanisms and there is no single factor. Symptoms of GERD are often non-typical, with a likelihood of being overlooked by non-gastroenterology professionals. Therefore, improving GERD awareness in non-gastroenterology practitioners, along with early diagnosis and treatment, provide potential benefit to clinicians and patients alike. Increasing evidence suggests GERD has specific connections with a variety of non-digestive tract conditions, may contribute an aggravating compounding effect on other diseases, prolong hospitalization, and increase subsequent medical costs. This review considers and emphasizes the association between GERD and non-digestive tract conditions, including atrial fibrillation, chronic obstructive pulmonary disease, primary pulmonary fibrosis and energy metabolism related to diet.
LETTERS AND COMMENTS: Comment on 'Reinterpreting the famous train/embankment experiment of relativity'

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Rowland, David R.

2004-09-01

Nelson (2003 Eur. J. Phys. 24 379) recently claimed on logical grounds that Einstein's train and embankment thought experiment cannot be used to prove the relativity of simultaneity prior to knowledge of the Lorentz transformations as it is purported to do. It is argued in this comment that Nelson's claim is based on premises which are incorrect, thus invalidating his conclusions. It is also argued that Nelson's article furnishes a 'proof by contradiction' of the desired result, thus also invalidating his claim.
Operant Conditioning in Older Adults with Alzheimer's Disease

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Spira, Adam P.; Edelstein, Barry A.

2007-01-01

Behavioral interventions based on operant principles are commonly attempted to manage agitation in older adults with dementia. The extent to which operant conditioning can occur in persons with particular dementias, however, is unclear. The present study involved use of a button-pressing task to evaluate the sensitivity of the responding of older…
Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease.

Science.gov (United States)

Majewski, Sebastian; Pietrzak, Anna; Tworek, Damian; Szewczyk, Karolina; Kumor-Kisielewska, Anna; Kurmanowska, Zofia; Górski, Paweł; Zalewska-Janowska, Anna; Piotrowski, Wojciech Jerzy

2017-01-01

The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this study was to investigate whether the systemic inflammation may influence the skin condition in COPD patients. Forty patients with confirmed diagnosis of COPD and a control group consisting of 30 healthy smokers and 20 healthy never-smokers were studied. Transepidermal water loss, stratum corneum hydration, skin sebum content, melanin index, erythema index, and skin temperature were measured with worldwide-acknowledged biophysical measuring methods at the volar forearm of all participants using a multifunctional skin physiology monitor. Biomarkers of systemic inflammation, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), were measured in serum using commercially available enzyme-linked immunosorbent assays. There were significant differences between COPD patients and healthy never-smokers in skin temperature, melanin index, sebum content, and hydration level ( P skin measured. The mean levels of hsCRP and IL-6 in serum were significantly higher in COPD patients and healthy smokers in comparison with healthy never-smokers. There were significant correlations between skin temperature and serum hsCRP ( R =0.40; P =0.02) as well as skin temperature and serum IL-6 ( R =0.49; P =0.005) in smokers. Stratum corneum hydration correlated significantly with serum TNF-α ( R =0.37; P =0.01) in COPD patients. Differences noted in several skin biophysical properties and biomarkers of systemic inflammation between COPD patients, smokers, and healthy never-smokers may suggest a possible link between smoking-driven, low-grade systemic inflammation, and the overall skin condition.
Addison′s disease

OpenAIRE

Soumya Brata Sarkar; Subrata Sarkar; Supratim Ghosh; Subhankar Bandyopadhyay

2012-01-01

Addison's disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison's disease. Classically, hyperpigmentation is associated with the disease, and intraoral pigmentation is perceived as the initial sign and develops earlier than the dermatological pigmentation. The symptoms of the disease usually progress slowly and an event of illness or accident can make the condition worse and may lead to a life-threatening cr...

Effects of a Cognitive Behavioral Therapy Intervention Trial to Improve Disease Outcomes in Children with Inflammatory Bowel Disease.

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Levy, Rona L; van Tilburg, Miranda A L; Langer, Shelby L; Romano, Joan M; Walker, Lynn S; Mancl, Lloyd A; Murphy, Tasha B; Claar, Robyn L; Feld, Shara I; Christie, Dennis L; Abdullah, Bisher; DuPen, Melissa M; Swanson, Kimberly S; Baker, Melissa D; Stoner, Susan A; Whitehead, William E

2016-09-01

Studies testing the efficacy of behavioral interventions to modify psychosocial sequelae of inflammatory bowel disease in children are limited. This report presents outcomes through a 6-month follow-up from a large randomized controlled trial testing the efficacy of a cognitive behavioral intervention for children with inflammatory bowel disease and their parents. One hundred eighty-five children aged 8 to 17 years with a diagnosis of Crohn's disease or ulcerative colitis and their parents were randomized to one of two 3-session conditions: (1) a social learning and cognitive behavioral therapy condition or (2) an education support condition designed to control for time and attention. There was a significant overall treatment effect for school absences due to Crohn's disease or ulcerative colitis (P cognitive behavioral therapy condition experienced a greater reduction in flares after treatment. This trial suggests that a brief cognitive behavioral intervention for children with inflammatory bowel disease and their parents can result in improved child functioning and quality of life, and for some children may decrease disease activity.
Peyronie's Disease.

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Taylor, Frederick L; Levine, Laurence A

2007-11-01

Peyronie's disease is a psychologically and physically devastating disorder that is manifest by a fibrous inelastic scar of the tunica albuginea, resulting in palpable penile scar in the flaccid condition and causing penile deformity, including penile curvature, hinging, narrowing, shortening, and painful erections. Peyronie's disease remains a considerable therapeutic dilemma even to today's practicing physicians.
Survival in dialysis patients is not different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition

NARCIS (Netherlands)

Schroijen, Marielle A.; Dekkers, Olaf M.; Grootendorst, Diana C.; Noordzij, Marlies; Romijn, Johannes A.; Krediet, Raymond T.; Boeschoten, Elisabeth W.; Dekker, Friedo W.; Apperloo, A. J.; Bijlsma, J. A.; Boekhout, M.; Boer, W. H.; van der Boog, P. J. M.; Büller, H. R.; van Buren, M.; de Charro, F. Th; Doorenbos, C. J.; van den Dorpel, M. A.; van Es, A.; Fagel, W. J.; Feith, G. W.; de Fijter, C. W. H.; Frenken, L. A. M.; van Geelen, J. A. C. A.; Gerlag, P. G. G.; Gorgels, J. P. M. C.; Grave, W.; Huisman, R. M.; Jager, K. J.; Jie, K.; Koning-Mulder, W. A. H.; Koolen, M. I.; Kremer Hovinga, T. K.; Lavrijssen, A. T. J.; Luik, A. J.; van der Meulen, J.; Parlevliet, K. J.; Raasveld, M. H. M.; van der Sande, F. M.; Schonck, M. J. M.; Schuurmans, M. M. J.; Siegert, C. E. H.; Stegeman, C. A.; Stevens, P.; Thijssen, J. G. P.; Valentijn, R. M.; Vastenburg, G. H.; Verburgh, C. A.; Vincent, H. H.; Vos, P. F.

2011-01-01

On dialysis, survival among patients with diabetes mellitus is inferior to survival of non-diabetic patients. We hypothesized that patients with diabetes as primary renal disease have worse survival compared to patients with diabetes as a co-morbid condition and aimed to compare all-cause mortality
A cross-sectional survey to study the relationship of periodontal disease with cardiovascular disease, respiratory disease, and diabetes mellitus.

Science.gov (United States)

Oberoi, Sukhvinder Singh; Harish, Yashoda; Hiremath, Shivalingaswamy; Puranik, Manjunath

2016-01-01

Periodontal deterioration has been reported to be associated with systemic diseases such as cardiovascular disease (CVD), diabetes mellitus, respiratory disease, liver cirrhosis, bacterial pneumonia, nutritional deficiencies, and adverse pregnancy outcomes. The present study assessed the periodontal disease among patients with systemic conditions such as diabetes, CVD, and respiratory disease. The study population consisted of 220 patients each of CVD, respiratory disease, and diabetes mellitus, making a total of 660 patients in the systemic disease group. A control group of 340 subjects were also included in the study for comparison purpose. The periodontal status of the patients with these confirmed medical conditions was assessed using the community periodontal index of treatment needs (CPITNs) index. The prevalence of CPITN code 4 was found to be greater among the patients with respiratory disease whereas the mean number of sextants with score 4 was found to be greater among the patients with diabetes mellitus and CVD. The treatment need 0 was found to be more among the controls (1.18%) whereas the treatment need 1, 2, and 3 were more among the patients with respiratory disease (100%, 97.73%, and 54.8%), diabetes mellitus (100%, 100% and 46.4%), and CVD (100%, 97.73%, and 38.1%), in comparison to the controls (6.18%). From the findings of the present study, it can be concluded that diabetes mellitus, CVD, and respiratory disease are associated with a higher severity of periodontal disease.
A cross-sectional survey to study the relationship of periodontal disease with cardiovascular disease, respiratory disease, and diabetes mellitus

Directory of Open Access Journals (Sweden)

Sukhvinder Singh Oberoi

2016-01-01

Full Text Available Background: Periodontal deterioration has been reported to be associated with systemic diseases such as cardiovascular disease (CVD, diabetes mellitus, respiratory disease, liver cirrhosis, bacterial pneumonia, nutritional deficiencies, and adverse pregnancy outcomes. Aim: The present study assessed the periodontal disease among patients with systemic conditions such as diabetes, CVD, and respiratory disease. Materials and Methods: The study population consisted of 220 patients each of CVD, respiratory disease, and diabetes mellitus, making a total of 660 patients in the systemic disease group. A control group of 340 subjects were also included in the study for comparison purpose. The periodontal status of the patients with these confirmed medical conditions was assessed using the community periodontal index of treatment needs (CPITNs index. Results: The prevalence of CPITN code 4 was found to be greater among the patients with respiratory disease whereas the mean number of sextants with score 4 was found to be greater among the patients with diabetes mellitus and CVD. The treatment need 0 was found to be more among the controls (1.18% whereas the treatment need 1, 2, and 3 were more among the patients with respiratory disease (100%, 97.73%, and 54.8%, diabetes mellitus (100%, 100% and 46.4%, and CVD (100%, 97.73%, and 38.1%, in comparison to the controls (6.18%. Conclusion: From the findings of the present study, it can be concluded that diabetes mellitus, CVD, and respiratory disease are associated with a higher severity of periodontal disease.
Do you think it's a disease? a survey of medical students

Directory of Open Access Journals (Sweden)

Erueti Chrissy

2012-04-01

Full Text Available Abstract Background The management of medical conditions is influenced by whether clinicians regard them as "disease" or "not a disease". The aim of the survey was to determine how medical students classify a range of conditions they might encounter in their professional lives and whether a different name for a condition would influence their decision in the categorisation of the condition as a 'disease' or 'not a disease'. Methods We surveyed 3 concurrent years of medical students to classify 36 candidate conditions into "disease" and "non-disease". The conditions were given a 'medical' label and a (lay label and positioned where possible in alternate columns of the survey. Results The response rate was 96% (183 of 190 students attending a lecture: 80% of students concurred on 16 conditions as "disease" (eg diabetes, tuberculosis, and 4 as "non-disease" (eg baldness, menopause, fractured skull and heat stroke. The remaining 16 conditions (with 21-79% agreement were more contentious (especially obesity, infertility, hay fever, alcoholism, and restless leg syndrome. Three pairs of conditions had both a more, and a less, medical label: the more medical labels (myalgic encephalomyelitis, hypertension, and erectile dysfunction were more frequently classified as 'disease' than the less medical (chronic fatigue syndrome, high blood pressure, and impotence, respectively, significantly different for the first two pairs. Conclusions Some conditions excluded from the classification of "disease" were unexpected (eg fractured skull and heat stroke. Students were mostly concordant on what conditions should be classified as "disease". They were more likely to classify synonyms as 'disease' if the label was medical. The findings indicate there is still a problem 30 years on in the concept of 'what is a disease'. Our findings suggest that we should be addressing such concepts to medical students.
Genetics Home Reference: Parkinson disease

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... Email Facebook Twitter Home Health Conditions Parkinson disease Parkinson disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Parkinson disease is a progressive disorder of the nervous ...
Liver Disease and Adult Vaccination

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... The Basics Adult Vaccination Resources for Healthcare Professionals Liver Disease and Adult Vaccination Recommend on Facebook Tweet ... critical for people with health conditions such as liver disease. If you have chronic liver disease, talk ...
Disease: H01030 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available with anterior horn cell disease (LAAHD) is a condition with fetal akinesia deformation sequence (FADS), multiple contract...eletal disease; Neurodegenerative disease GLE1 [HSA:2733] [KO:K18723] ... Lethal congenital contract
Pregnancy and periodontal disease

OpenAIRE

Sağlam, Ebru; Saruhan, Nesrin; Çanakçı, Cenk Fatih

2015-01-01

Some maternal immunological changes due to pregnancy increases susceptibility to infections. Periodontal disease, the main cause is plaque, is a common disease which is seen multifactorial and varying severity. There are many clinical criteria for diagnosis of periodontal disease. Correlation between pregnancy and periodontal inflammation is known for many years. Periodontal disease affects pregnant’s systemic condition and also has negative effects on fetus. Periodontal disease increases the...
ORIGINAL ARTICLES Epidemiology of HIV in South Africa - results ...

African Journals Online (AJOL)

The Nelson MandelaiHuman Sciences Research Council. (HSRC) study of HIV I AIDS5 ..... This study was funded by the Nelson Mandela Foundation, ... Cape Town: Centre for Actuarial Research, Medical Research Council and the Actuarial ...
Hydrocele

Science.gov (United States)

... Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 346. Elder JS. Disorders and anomalies ... Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 545. Ferri FF. Hydrocele. In: Ferri ...
Epstein-Barr virus viral load and serology in childhood non-Hodgkin's lymphoma and chronic inflammatory conditions in Uganda: implications for disease risk and characteristics.

Science.gov (United States)

Orem, Jackson; Sandin, Sven; Mbidde, Edward; Mangen, Fred Wabwire; Middeldorp, Jaap; Weiderpass, Elisabete

2014-10-01

Epstein-Barr virus (EBV) has been linked to malignancies and chronic inflammatory conditions. In this study, EBV detection was compared in children with non-Hodgkin's lymphoma and children with chronic inflammatory conditions, using samples and data from a case-control study carried out at the Mulago National Referral Hospital between 2004 and 2008. EBV viral load was measured in saliva, whole blood and white blood cells by real-time PCR. Serological values for IgG-VCA, EBNA1, and EAd-IgG were compared in non-Hodgkin's lymphoma and chronic inflammatory conditions; and in Burkitt's lymphoma and other subtypes of non-Hodgkin's lymphoma. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Of the 127 children included (87 males and 40 females; median age 7 years, range 2-17), 96 had non-Hodgkin's lymphoma (46 Burkitt's lymphoma and 50 other non-Hodgkin's lymphoma), 31 had chronic inflammatory conditions, and only 10% were HIV-positive. The most common clinical presentations for all disease categories considered were fever, night sweats, and weight loss. EBV viral load in whole blood was elevated in Burkitt's lymphoma compared to other non-Hodgkin's lymphoma (OR 6.67, 95% CI 1.32, 33.69; P-value = 0.04), but EBV viral loads in saliva and white blood cells were not different in any of the disease categories considered. A significant difference in EAd-IgG was observed when non-Hodgkin's lymphoma was compared with chronic inflammatory conditions (OR 0.19, 95% CI 0.07, 0.51; P-value = 0.001). When compared to chronic inflammatory conditions, EBV viral load was elevated in Burkitt's lymphoma, and EA IgG was higher in non-Hodgkin's lymphoma. This study supports an association between virological and serological markers of EBV and childhood non-Hodgkin's lymphoma, irrespective of subtype, in Uganda. © 2014 Wiley Periodicals, Inc.
Conditional Melanoma Cancer Survival in the United States

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Ray M. Merrill

2016-02-01

Full Text Available Beyond relative survival, which indicates the likelihood that patients will not die from causes associated with their cancer, conditional relative survival probabilities provide further useful prognostic information to cancer patients, tailored to the time already survived from diagnosis. This study presents conditional relative survival for melanoma patients in the United States, diagnosed during 2000–2008 and followed through 2012. Analyses are based on 62,803 male and 50,261 female cases in population-based cancer registries in the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Five-year relative survival estimates are presented for melanoma patients who have already survived one, two, three, four, or five years after the initial diagnosis. Five- and ten-year relative survival decreases with age, stage at diagnosis, and is lower among males, Blacks, and Hispanics. Five-year conditional relative survival improves with each year already survived. The potential for improvement in five-year conditional relative survival is greatest for older age, males, Blacks, Hispanics, and in later staged cases. For local disease, five-year conditional relative survival was significantly lower in ages greater than 65 years and in Blacks. It was significantly higher in females, non-Hispanics, and married individuals. Age had a greater inverse relationship with five-year survival in later staged disease. A similar result occurred for females and married individuals. In contrast, non-Hispanics had better five-year survival if diagnosed with local or regional disease, but not distant disease.
Genetics Home Reference: Cole disease

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... Email Facebook Twitter Home Health Conditions Cole disease Cole disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Cole disease is a disorder that affects the skin. People ...
Genetics Home Reference: Norrie disease

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... Email Facebook Twitter Home Health Conditions Norrie disease Norrie disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Norrie disease is an inherited eye disorder that leads to ...
Clinical studies on thyroid diseases

NARCIS (Netherlands)

Eskes, S.A.

2014-01-01

This thesis focuses on some aspects of thyroid disease: prevention of autoimmune thyroid disease (AITD), diagnosis of related conditions as autoimmune hypophysitis in autoimmune hypothyroidism (Hashimoto’s disease), and treatment of amiodarone-induced thyrotoxicosis (AIT).
Comment on 'Reinterpreting the famous train/embankment experiment of relativity'

International Nuclear Information System (INIS)

Rowland, David R

2004-01-01

Nelson (2003 Eur. J. Phys. 24 379) recently claimed on logical grounds that Einstein's train and embankment thought experiment cannot be used to prove the relativity of simultaneity prior to knowledge of the Lorentz transformations as it is purported to do. It is argued in this comment that Nelson's claim is based on premises which are incorrect, thus invalidating his conclusions. It is also argued that Nelson's article furnishes a 'proof by contradiction' of the desired result, thus also invalidating his claim. (letters and comments)
Stochastic mechanics of mixed states

International Nuclear Information System (INIS)

Jaekel, M.T.; Pignon, D.

1984-01-01

Nelson's stochastic interpretation of quantum mechanics is extended from the case of pure states to that of mixed states. It is shown that a pure probabilistic formalism, which applies the Newton-Nelson Law to the initial position and velocity distributions, does not reproduce the time evolution predicted by quantum mechanics. In order to recover the latter, a new notion must be introduced, that of pure quantum states, over which the mixture has to be decomposed, and which then satisfy the Newton-Nelson Law independently. (author)
The analysis of health condition and the assessment of the risk of neoplastic diseases among residents of villages

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Anna Lewandowska

2017-06-01

Full Text Available Introduction: Neoplastic diseases have been classified as civilization diseases and are a big problem for modern medicine. According to the data from the International Agency for Research of Cancer, about 10 million people suffer from cancer and a number of deaths due to this disease has exceeded 6 million; until 2020 those numbers may double. In Poland, cancer survivors of five years concern 22% of men and 35% of women suffering from tumours, while in northern and western Europe there is a cure rate of 40% for men and 50% for women. The main reason for the adverse situation in Poland is a low percentage of early diagnosis of cancer. On the one hand this results from insufficient preparation of both family doctors and physicians of other specialties, but on the other, from insufficient dissemination of early diagnosis methods. Objective: The objective of the study is to analyze the health condition and to assess the risk of a neoplastic disease among residents of villages. Material and methods: The research involved 1000 residents of villages in Podkarpackie Voivodeship. The age of the researched ranges from 18 to 30 years, with mean age 26.96±0.84 (range [18;30], median 25.95%CI [18,9;29,01]. The researched group is represented in 43,8% by women in 56,2% by men. In order to obtain the research material, a standardized questionnaire has been applied including interview and physical examination, enabling assessment of symptoms reported during the interview and analysis of symptoms indicating a disease, including cancer. Results: According to the data analysis, during last few months the respondents have suffered from such ailments as cough (8.22% W, 7.12% M, dyspnea (3.2% W, 1.78% M, abdominal pain (13.7% W, 4.27% M, pain (5.48% W, 2.14% M and weakness (14.61% W, 4.98% M. During observations, one female respondent was diagnosed with symptoms of melanoma (0.46%, which has been confirmed in later dermatological test. Conclusions: No changes in

Periodontal disease and systemic diseases in an older population.

Science.gov (United States)

Özçaka, Özgün; Becerik, Sema; Bıçakcı, Nurgün; Kiyak, Asuman H

2014-01-01

To evaluate the relationship between older adults' medical and oral conditions and their self-reports of periodontal conditions with clinically obtained data. Concerns about oral health of elders and its association with systemic diseases have been gaining more attention. A total of 201 older subjects were interviewed about their previous medical and dental histories and were asked to complete a health questionnaire. Each subject received full mouth exam, including counting number of natural teeth remaining, gingival (GI) and plaque index (PI), CPITN and denture status. Elders who completed health questionnaires had mean age of 62.5. Mean CPITN score was 1.62(± 1.12), PI was 1.57(± 1.48), and GI was 1.55(± 1.31). Women had higher prevalence of CVD and osteoporosis than men (p=0.008, p=0.0001, respectively). Subjects who reported bleeding upon brushing had higher PI and GI scores (p=0.03, p=0.05, respectively). Smokers were more likely to describe their periodontal tissues as unhealthy (72.3% vs. 27.7%, p=0.01), whereas self-reports of healthy vs. unhealthy gums did not differ between non-smokers. These findings suggest that a number of systemic conditions are associated with indicators of periodontal disease, and self-reports of oral conditions are independent of systemic diseases. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease.

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Juliane Obermeier

Full Text Available Monitoring metabolic adaptation to chronic kidney disease (CKD early in the time course of the disease is challenging. As a non-invasive technique, analysis of exhaled breath profiles is especially attractive in children. Up to now, no reports on breath profiles in this patient cohort are available. 116 pediatric subjects suffering from mild-to-moderate CKD (n = 48 or having a functional renal transplant KTx (n = 8 and healthy controls (n = 60 matched for age and sex were investigated. Non-invasive quantitative analysis of exhaled breath profiles by means of a highly sensitive online mass spectrometric technique (PTR-ToF was used. CKD stage, the underlying renal disease (HUS; glomerular diseases; abnormalities of kidney and urinary tract or polycystic kidney disease and the presence of a functional renal transplant were considered as classifiers. Exhaled volatile organic compound (VOC patterns differed between CKD/ KTx patients and healthy children. Amounts of ammonia, ethanol, isoprene, pentanal and heptanal were higher in patients compared to healthy controls (556, 146, 70.5, 9.3, and 5.4 ppbV vs. 284, 82.4, 49.6, 5.30, and 2.78 ppbV. Methylamine concentrations were lower in the patient group (6.5 vs 10.1 ppbV. These concentration differences were most pronounced in HUS and kidney transplanted patients. When patients were grouped with respect to degree of renal failure these differences could still be detected. Ammonia accumulated already in CKD stage 1, whereas alterations of isoprene (linked to cholesterol metabolism, pentanal and heptanal (linked to oxidative stress concentrations were detectable in the breath of patients with CKD stage 2 to 4. Only weak associations between serum creatinine and exhaled VOCs were noted. Non-invasive breath testing may help to understand basic mechanisms and metabolic adaptation accompanying progression of CKD. Our results support the current notion that metabolic adaptation occurs early during the time
The Perceived Medical Condition Self-Management Scale can be applied to patients with chronic kidney disease.

Science.gov (United States)

Wild, Marcus G; Wallston, Kenneth A; Green, Jamie A; Beach, Lauren B; Umeukeje, Ebele; Wright Nunes, Julie A; Ikizler, T Alp; Steed, Julia; Cavanaugh, Kerri L

2017-10-01

Chronic Kidney Disease (CKD) is a major burden on patients and the health care system. Treatment of CKD requires dedicated involvement from both caretakers and patients. Self-efficacy, also known as perceived competence, contributes to successful maintenance of patient's CKD self-management behaviors such as medication adherence and dietary regulations. Despite a clear association between self-efficacy and improved CKD outcomes, there remains a lack of validated self-report measures of CKD self-efficacy. To address this gap, the Perceived Kidney/Dialysis Self-Management Scale (PKDSMS) was adapted from the previously validated Perceived Medical Condition Self-Management Scale. We then sought to validate this using data from two separate cohorts: a cross-sectional investigation of 146 patients with end-stage renal disease receiving maintenance hemodialysis and a longitudinal study of 237 patients with CKD not receiving dialysis. The PKDSMS was found to be positively and significantly correlated with self-management behaviors and medication adherence in both patient cohorts. The PKDSMS had acceptable reliability, was internally consistent, and exhibited predictive validity between baseline PKDSMS scores and self-management behaviors across multiple time points. Thus, the PKDSMS is a valid and reliable measure of CKD patient self-efficacy and supports the development of interventions enhancing perceived competence to improve CKD self-management. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Genetics Home Reference: Hirschsprung disease

Science.gov (United States)

... occur in combination with other conditions, such as Waardenburg syndrome , type IV; Mowat-Wilson syndrome ; or congenital central ... Disease MalaCards: hirschsprung disease 1 Orphanet: Hirschsprung disease Patient Support and Advocacy Resources (4 links) Bowel Group ...
An architecture for synchronous micro-volunteering in Africa using social media

CSIR Research Space (South Africa)

Butgereit, L

2013-03-01

Full Text Available -1 An Architecture for Synchronous Micro-Volunteering in Africa using Social Media Laurie Butgereit Nelson Mandela Metropolitan University and Meraka Institute, CSIR, South Africa lbutgereit@meraka.org.za Reinhardt A Botha Nelson Mandela Metropolitan...
Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin

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Lauren Veltri

2013-01-01

Full Text Available Nonmyeloablative (NMA conditioning with total lymphoid irradiation and antithymocyte globulin (TLI/ATG has been shown to protect against acute graft-versus-host disease (GVHD. We report here our institutional experience with allogeneic transplantation following NMA conditioning with TLI/ATG (. GVHD prophylaxis consisted of a combination of a calcineurin inhibitor and mycophenolate mofetil. Median patient age was 59 years. The median followup of surviving patients is 545 days. One patient experienced primary graft rejection. The median time to neutrophil engraftment was 18 days and platelet engraftment was 9.5 days. The cumulative incidence (CI of grade II–IV acute GVHD at day +100 was 28.6% and 38.1% at day +180. The CI for grade III-IV acute GVHD was 28.6% at day +180. CI of chronic GVHD was 45.2% at 1 year. The CI of disease relapse was 9.5% at 1 year. The rate of nonrelapse mortality (NRM was 0% at day +100 and only 9.5% at 1 year. The overall and progression free survival at 1 year was 81% and 80.4%, respectively. Our limited, retrospective data show encouraging relapse and NRM rates with TLI/ATG-based NMA conditioning, but with higher than previously reported rates of acute and chronic GVHD, underscoring the need for novel strategies designed to effectively prevent GVHD.
Hirschsprung disease.

Science.gov (United States)

Haricharan, Ramanath N; Georgeson, Keith E

2008-11-01

Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation. More recently, definitive surgery for Hirschsprung disease through minimally invasive techniques has gained popularity. In neonates, the advancement of treatment strategies for Hirschsprung disease continues with reduced patient morbidity and improved outcomes.
Kashin-Beck's disease

NARCIS (Netherlands)

Moerman, J.; Uyttendaele, D.; Broecke, van den W.; Claessens, H.A.

1992-01-01

A case of Kashin-Beck's disease is presented. It is an acquired, disabling, polyarthritic, degenerative condition of early onset, sometimes leading to a variable degree of dwarfism. It occurs endemically in certain Asian areas. Treatment is, if possible, preventive. In the established disease the
Celiac disease and new diseases related to gluten

Science.gov (United States)

Jiménez Ortega, Ana Isabel; Martínez García, Rosa María; Quiles Blanco, María José; Majid Abu Naji, Jamil Abdel; González Iglesias, María José

2016-07-12

Celiac disease is the most common chronic intestinal disease. Nowadays it´s known that this is a multisistemic pathology of immune mechanism, triggered by gluten, which occurs in genetically susceptible individuals. It affects approximately 1% of the world population, which is a very high prevalence, affects all age groups and has symptoms both digestive and extra-digestive. Since it is a disease that requires maintaining a gluten-free diet and medical monitoring for life, it is important to know it and establish its diagnosis properly. Along with celiac disease a number of new diseases related to gluten are diagnosed increasingly, including the non celiac gluten sensitivity or wheat allergy. The suffering of celiac disease, or other related diseases, by conditioning diet changes of the affected individual, it may be associated with nutritional imbalances that need to monitor and try to solve. Therefore patients with this problem need special nutritional advice.
NEONATAL SURGERY, A STUDY OF TWO YEARS AT NELSON MANDELA ACADEMIC HOSPITAL, MTHATHA, EASTERN CAPE.

Science.gov (United States)

Delgado, A; Cejas, A; Bangasa, D

2017-09-01

Advances in diagnostic techniques and perioperative care have greatly improved the outcome of neonatal surgery. Despite this, disparity still exists in the outcome of neonatal surgery between developed and developing countries. We performed a prospective study of neonates admitted and treated due to surgical congenital diseases and other conditions in our hospital from April 2015 to April 2017. There were 19 (28,7%) females and 47 (70,3%) males in this group. It was found that 41 neonates had 7 days after birth or less by a 62% and 25 with more than 7 days by 38%. The Anorectal malformations (ARM) were the most frequent congenital anomaly in 21 patients (47%), followed by Gastroquises with 7 neonates (10,6%), Omphalocele with 8 (12%), and Oesophagus Atresia in 5 neonates (7,5%). Intestinal Malrotation with midgut volvulus, Pyloric Stenoses and Duodenal Atresia in 4 neonates (6,2 % each). Others alterations such as, Ileal Atresia, Strangulated Inguinal Hernia, Limb Gangrene, Necrotizing Enterocolitis, Sacro Coxigeal Theratoma, Megacolon Aganglionic, Colon perforation, Gastric perforation and Hydromethrocolpus accounted in 13 neonates by 19,7% from the total of patients. Ten babies died (15%). We conclude that Anorectal Malformations, Gastroquises and Omphalocele were the most frequent malformations. Considering the mortality is above the average of developed countries this could be improved by increasing the knowledge about the neonatal surgery characteristics among medical doctors and improving the necessary facilities and back up.
Fisetin and Its Role in Chronic Diseases.

Science.gov (United States)

Pal, Harish C; Pearlman, Ross L; Afaq, Farrukh

2016-01-01

Chronic inflammation is a prolonged and dysregulated immune response leading to a wide variety of physiological and pathological conditions such as neurological abnormalities, cardiovascular diseases, diabetes, obesity, pulmonary diseases, immunological diseases, cancers, and other life-threatening conditions. Therefore, inhibition of persistent inflammation will reduce the risk of inflammation-associated chronic diseases. Inflammation-related chronic diseases require chronic treatment without side effects. Use of traditional medicines and restricted diet has been utilized by mankind for ages to prevent or treat several chronic diseases. Bioactive dietary agents or "Nutraceuticals" present in several fruits, vegetables, legumes, cereals, fibers, and certain spices have shown potential to inhibit or reverse the inflammatory responses and several chronic diseases related to chronic inflammation. Due to safe, nontoxic, and preventive benefits, the use of nutraceuticals as dietary supplements or functional foods has increased in the Western world. Fisetin (3,3',4',7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and in animal models relevant to human diseases. In this chapter, we discuss the beneficial pharmacological effects of fisetin against different pathological conditions with special emphasis on diseases related to chronic inflammatory conditions.
PERIODONTAL CONDITIONS IN EUROPE

NARCIS (Netherlands)

PILOT, T; MIYAZAKI, H

The aim of the present overview is to evaluate the periodontal conditions in European populations. Study was made of a number of extensive surveys of periodontal diseases carried out in a number of European countries, primarily North West Europe. These surveys often provide considerable detail.
Gum Disease and Men

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... Club Program Perio Store Education & Careers Careers in Periodontics Perio Exam for Dental Licensure Recommended Competencies Periodontal ... your risk of cardiovascular disease. Both diseases are chronic inflammatory conditions, and researchers believe that inflammation is ...
'Patents and Downstream Innovation Suppression - Fact or Fiction?'

DEFF Research Database (Denmark)

Howells, John

Merges and Nelson have provided an empirically grounded argument that firms use pioneer patents of 'broad' scope to block downstream technological development (Merges and Nelson 1990). If this is a regular occurrence then, as they claim, they have faulted Kitch's 'prospect theory' of patents (Kitch...... 1977), a theory that is a version of the classic justification for the award of the exclusive right - that it should protect the incentive to develop property. Merges and Nelson insist that their thesis should be supported by empirical evidence and they turn to historical accounts as an important form...
Multiple chronic conditions and life expectancy: a life table analysis.

Science.gov (United States)

DuGoff, Eva H; Canudas-Romo, Vladimir; Buttorff, Christine; Leff, Bruce; Anderson, Gerard F

2014-08-01

The number of people living with multiple chronic conditions is increasing, but we know little about the impact of multimorbidity on life expectancy. We analyze life expectancy in Medicare beneficiaries by number of chronic conditions. A retrospective cohort study using single-decrement period life tables. Medicare fee-for-service beneficiaries (N=1,372,272) aged 67 and older as of January 1, 2008. Our primary outcome measure is life expectancy. We categorize study subjects by sex, race, selected chronic conditions (heart disease, cancer, chronic obstructive pulmonary disease, stroke, and Alzheimer disease), and number of comorbid conditions. Comorbidity was measured as a count of conditions collected by Chronic Conditions Warehouse and the Charlson Comorbidity Index. Life expectancy decreases with each additional chronic condition. A 67-year-old individual with no chronic conditions will live on average 22.6 additional years. A 67-year-old individual with 5 chronic conditions and ≥10 chronic conditions will live 7.7 fewer years and 17.6 fewer years, respectively. The average marginal decline in life expectancy is 1.8 years with each additional chronic condition-ranging from 0.4 fewer years with the first condition to 2.6 fewer years with the sixth condition. These results are consistent by sex and race. We observe differences in life expectancy by selected conditions at 67, but these differences diminish with age and increasing numbers of comorbid conditions. Social Security and Medicare actuaries should account for the growing number of beneficiaries with multiple chronic conditions when determining population projections and trust fund solvency.
Friction pressure drop and heat transfer coefficient of two-phase flow in helically coiled tube once-through steam generator for integrated type marine water reactor

International Nuclear Information System (INIS)

Nariai, Hideki; Kobayashi, Michiyuki; Matsuoka, Takeshi.

1982-01-01

Two-phase friction pressure drop and heat transfer coefficients in a once-through steam generator with helically coiled tubes were investigated with the model test rig of an integrated type marine water reactor. As the dimensions of the heat transfer tubes and the thermal-fluid conditions are almost the same as those of real reactors, the data applicable directly to the real reactor design were obtained. As to the friction pressure drop, modified Kozeki's prediction which is based on the experimental data by Kozeki for coiled tubes, agreed the best with the experimental data. Modified Martinelli-Nelson's prediction which is based on Martinelli-Nelson's multiplier using Ito's equation for single-phase flow in coiled tube, agreed within 30%. The effect of coiled tube on the average heat transfer coefficients at boiling region were small, and the predictions for straight tube could also be applied to coiled tube. Schrock-Grossman's correlation agreed well with the experimental data at the pressures of lower than 3.5 MPa. It was suggested that dryout should be occurred at the quality of greater than 90% within the conditions of this report. (author)
Anemia in Chronic Kidney Disease

Science.gov (United States)

... artérielle Heart Disease Mineral & Bone Disorder Anemia in Chronic Kidney Disease What is anemia? Anemia is a condition in ... as they should. How is anemia related to chronic kidney disease? Anemia commonly occurs in people with chronic kidney ...
Oral Health Conditions of Older People: Focus on the Balkan Countries

OpenAIRE

Chatzopoulos Georgios S.

2015-01-01

Oral health plays a pivotal role in general health, especially in older people. Oral diseases may affect the development of systemic conditions, such as diabetes mellitus, cardiovascular disease, stroke and hypertension. The most important oral health conditions that have been recorded in dental literature for older population include tooth loss, dental caries, periodontal diseases, xerostomia (dry mouth) and oral cancer. Edentulism influences social life, either causing aesthetic problems or...
Celiac disease and other autoimmune diseases in patients with collagenous colitis.

Science.gov (United States)

Vigren, Lina; Tysk, Curt; Ström, Magnus; Kilander, Anders F; Hjortswang, Henrik; Bohr, Johan; Benoni, Cecilia; Larson, Lasse; Sjöberg, Klas

2013-08-01

Collagenous colitis (CC) is associated with autoimmune disorders. The aim of the present study was to investigate the relationship between CC and autoimmune disorders in a Swedish multicenter study. Patients with CC answered questionnaires about demographic data and disease activity. The patient's files were scrutinized for information about autoimmune diseases. A total number of 116 CC patients were included; 92 women, 24 men, median age 62 years (IQR 55-73). In total, 30.2% had one or more autoimmune disorder. Most common were celiac disease (CeD; 12.9%) and autoimmune thyroid disease (ATD, 10.3%), but they also had Sjögren's syndrome (3.4%), diabetes mellitus (1.7%) and conditions in skin and joints (6.0%). Patients with associated autoimmune disease had more often nocturnal stools. The majority of the patients with associated CeD or ATD got these diagnoses before the colitis diagnosis. Autoimmune disorders occurred in one-third of these patients, especially CeD. In classic inflammatory bowel disease (IBD), liver disease is described in contrast to CC where no cases occurred. Instead, CeD was prevalent, a condition not reported in classic IBD. Patients with an associated autoimmune disease had more symptoms. Patients with CC and CeD had an earlier onset of their colitis. The majority of the patients with both CC and CeD were smokers. Associated autoimmune disease should be contemplated in the follow-up of these patients.
Childhood Interstitial Lung Disease

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... rule out conditions such as asthma , cystic fibrosis , acid reflux, heart disease, neuromuscular disease, and immune deficiency. Various ... a lung infection. Acid-blocking medicines can prevent acid reflux, which can lead to aspiration. Lung Transplant A ...

Aspirin and heart disease

Science.gov (United States)

... medlineplus.gov/ency/patientinstructions/000092.htm Aspirin and heart disease To use the sharing features on this page, ... healthy people who are at low risk for heart disease. You provider will consider your overall medical condition ...
Causal inference regarding infectious aetiology of chronic conditions: a systematic review.

Directory of Open Access Journals (Sweden)

Sofia Orrskog

Full Text Available BACKGROUND: The global burden of disease has shifted from communicable diseases in children to chronic diseases in adults. This epidemiologic shift varies greatly by region, but in Europe, chronic conditions account for 86% of all deaths, 77% of the disease burden, and up to 80% of health care expenditures. A number of risk factors have been implicated in chronic diseases, such as exposure to infectious agents. A number of associations have been well established while others remain uncertain. METHODS AND FINDINGS: We assessed the body of evidence regarding the infectious aetiology of chronic diseases in the peer-reviewed literature over the last decade. Causality was assessed with three different criteria: First, the total number of associations documented in the literature between each infectious agent and chronic condition; second, the epidemiologic study design (quality of the study; third, evidence for the number of Hill's criteria and Koch's postulates that linked the pathogen with the chronic condition. We identified 3136 publications, of which 148 were included in the analysis. There were a total of 75 different infectious agents and 122 chronic conditions. The evidence was strong for five pathogens, based on study type, strength and number of associations; they accounted for 60% of the associations documented in the literature. They were human immunodeficiency virus, hepatitis C virus, Helicobacter pylori, hepatitis B virus, and Chlamydia pneumoniae and were collectively implicated in the aetiology of 37 different chronic conditions. Other pathogens examined were only associated with very few chronic conditions (≤ 3 and when applying the three different criteria of evidence the strength of the causality was weak. CONCLUSIONS: Prevention and treatment of these five pathogens lend themselves as effective public health intervention entry points. By concentrating research efforts on these promising areas, the human, economic, and societal
Periodontal disease and systemic complications

Directory of Open Access Journals (Sweden)

Rui Vicente Oppermann

2012-01-01

Full Text Available Periodontal diseases comprise a number of infectious and inflammatory conditions brought about by the interaction between supragingival and subgingival biofilms and the host inflammatory response. Periodontal diseases should be considered systemic conditions. This means that they are both modulated by the body's systems and play a role as a risk factor for systemic derangements. The current evidence supports some of these interactions, such as smoking as a risk factor for periodontal disease and diabetes mellitus, as both influenced by and influencing inflammatory changes in the periodontal tissue. Other potential associations are still being researched, such as obesity, hormonal changes, cardiovascular disease, and adverse outcomes in pregnancy. These, and others, still require further investigation before the repercussions of periodontal disease can be fully elucidated. Nevertheless, at the present time, the treatment of periodontal diseases-and, most importantly, their prevention-enables adequate intervention as a means of ensuring periodontal health.
Modeling systemic autoimmune rheumatic disease in rats under the adverse weather conditions

Directory of Open Access Journals (Sweden)

Yegudina Ye.D.

2017-04-01

Full Text Available Changes in the lungs, heart and kidneys are found in all animals with experimental systemic autoimmune rheumatic disease and respectively in 47%, 47% and 40% of cases of intact rats in a hostile environment with xenobiotics air pollution (ammonia + benzene + formalin, herewith in every third or fourth individual lesions of visceral vessels developed. The negative environmental situation increases the frequency of morphological signs of the disease, such as proliferation of endothelial vessels of the heart by 68% and renal arterioles by 52%, in addition, there are direct correlations of angiopathy degree in individual organs; this depends on the nature of pathological process modeling and demonstrates air pollution as a risk factor of disease in humans. The impact of pulmonary vessels sclerosis on the development of bronhosclerosis, perivascular infiltration of the heart muscle on the lymphocyte-macrophage infiltration of the stroma of the myocardium and sclerosis of renal arterioles on the degree of nephroslerosis of stroma is directly associated, with the model of systemic autoimmune rheumatic diseases whereas air pollution by xenobiotics determines dependences of the degree of cellular infiltration of alveolar septa from perivascular pulmonary infiltration, the development of cardiomyocytes hypertrophy from proliferation of the heart endothelial vessels, increase of kidney mesangial matrix from the proliferation of endothelial glomerular capillaries.
The development of biomarkers for degenerative musculoskeletal conditions.

Science.gov (United States)

Jayabalan, Prakash; Sowa, Gwendolyn A

2014-02-01

With an aging population, degenerative musculoskeletal conditions will become more prevalent with significantly increasing costs to society over the next several decades. The majority of these conditions are diagnosed radiographically, at which point the disease process is often more advanced and challenging to treat. The commonly available radiographic studies also do not adequately provide information as to the exact pain generator and findings often do not correlate either to patient symptoms or function. Personalized medicine involves formulating treatments based on a patient's own biology. The development of biological markers (biomarkers) pertaining to disease is a rapidly growing area within this field of medicine. For degenerative musculoskeletal conditions, biomarkers have the potential to provide an early non-invasive method of assessing the location and severity of tissue damage and presence of inflammation. By outlining mechanisms of disease they could allow the formulation of further treatment targets and through sub-categorizing patients into different groups based on their biomarker profile, one could provide more efficacious treatments for patients. The present article is a review of the development of biomarkers for these purposes specifically as they pertain to degenerative musculoskeletal conditions.
Reliability and Agreement in Student Ratings of the Class Environment

Science.gov (United States)

Nelson, Peter M.; Christ, Theodore J.

2016-01-01

The current study estimated the reliability and agreement of student ratings of the classroom environment obtained using the Responsive Environmental Assessment for Classroom Teaching (REACT; Christ, Nelson, & Demers, 2012; Nelson, Demers, & Christ, 2014). Coefficient alpha, class-level reliability, and class agreement indices were…
There is no Parkinson disease.

Science.gov (United States)

Weiner, William J

2008-06-01

The term Parkinson disease defines a specific clinical condition characterized by a typical history and characteristic signs. This review examines the historical evolution of the concept of Parkinson disease and how the misunderstanding of Parkinson disease may be hindering clinical research trials. It is proposed that this syndrome be called Parkinson diseases or parkinsonism type 1 through infinity.
Celiac Disease in Patients with Cystic Fibrosis-Related Bone Disease

Directory of Open Access Journals (Sweden)

Melissa S. Putman

2017-01-01

Full Text Available Both cystic fibrosis (CF and celiac disease can cause low bone mineral density (BMD and fractures. Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications for treatment. Clinicians should consider screening for celiac disease in patients with CF who have low BMD, worsening BMD in the absence of other risk factors, and/or difficult to treat vitamin D deficiency.
CDC Vital Signs: Legionnaires' Disease

Science.gov (United States)

... gov . Vital Signs Topics Covered Alcohol Antibiotic Resistance Cancer Cardiovascular Diseases Diseases & Conditions Food Safety Healthcare-associated Infections Healthy Living HIV / AIDS Injury, Violence & Safety Motor Vehicle Safety Obesity ...
Research prioritization of men’s health and urologic diseases

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Tyler Okland

Full Text Available ABSTRACT Objectives We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR reflects disease burden, measured by the Global Burden of Disease (GBD Study as disability-adjusted life-years (DALYs. Materials and Methods Two investigators performed independent assessment of ten men’s health and urologic diseases (MHUDs in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis. Results Nine of ten MHUDs were represented by at least one CDSR review. There was a poor and statistically insignificant positive correlation between CDSR representation and disease burden (rho = 0.42, p = 0.23. CDSR representation was aligned with disease burden for three conditions, greater than disease burden for one condition, and less than disease burden for six conditions. Conclusions These results yield high-quality estimates to inform future research prioritization for MHUDs. While prioritization processes are complex and multi-faceted, disease burden should be strongly considered. Awareness of research priority setting has the potential to minimize research disparities on a global scale.
The Role of the Global SOF Network in a Resource Constrained Environment

Science.gov (United States)

2013-11-01

introduced new legislation under the Nelson Mandela regime, the Regulation of Foreign Military Assistance Act, which prohibited South Africans from...3. President Obama’s 3 January 2012 Forward to the January 2012 Defense Strategic Guidance. 4. Rick “Ozzie” Nelson and Michael Stieg, Center for
Prevalence of chronic medical conditions among inmates in the Texas prison system.

Science.gov (United States)

Harzke, Amy J; Baillargeon, Jacques G; Pruitt, Sandi L; Pulvino, John S; Paar, David P; Kelley, Michael F

2010-05-01

Given the rapid growth and aging of the US prison population in recent years, the disease profile and health care needs of inmates portend to have far-reaching public health implications. Although numerous studies have examined infectious disease prevalence and treatment in incarcerated populations, little is known about the prevalence of non-infectious chronic medical conditions in US prison populations. The purpose of this study was to estimate the prevalence of selected non-infectious chronic medical conditions among inmates in the Texas prison system. The study population consisted of the total census of inmates who were incarcerated in the Texas Department of Criminal Justice for any duration from September 1, 2006 through August 31, 2007 (N=234,031). Information on medical diagnoses was obtained from a system-wide electronic medical record system. Overall crude prevalence estimates for the selected conditions were as follows: hypertension, 18.8%; asthma, 5.4%; diabetes, 4.2%; ischemic heart disease, 1.7%; chronic obstructive pulmonary disease, 0.96%; and cerebrovascular disease, 0.23%. Nearly one quarter (24.5%) of the study population had at least one of the selected conditions. Except for asthma, crude prevalence estimates of the selected conditions increased monotonically with age. Nearly two thirds (64.6%) of inmates who were >or=55 years of age had at least one of the selected conditions. Except for diabetes, crude prevalence estimates for the selected conditions were lower among Hispanic inmates than among non-Hispanic White inmates and African American inmates. Although age-standardized prevalence estimates for the selected conditions did not appear to exceed age-standardized estimates from the US general population, a large number of inmates were affected by one or more of these conditions. As the prison population continues to grow and to age, the burden of these conditions on correctional and community health care systems can be expected to increase.
Disease: H01582 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available nal deficiencies, like alcoholism. Metabolic disorders; Nervous system disease; Skin disease ... Nicotinami...no acid precursor tryptophan. ... It is currently seen in association with other conditions of chronic nutritio
Telehealth Interventions to Support Self-Management of Long-Term Conditions: A Systematic Metareview of Diabetes, Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, and Cancer.

Science.gov (United States)

Hanlon, Peter; Daines, Luke; Campbell, Christine; McKinstry, Brian; Weller, David; Pinnock, Hilary

2017-05-17

Self-management support is one mechanism by which telehealth interventions have been proposed to facilitate management of long-term conditions. The objectives of this metareview were to (1) assess the impact of telehealth interventions to support self-management on disease control and health care utilization, and (2) identify components of telehealth support and their impact on disease control and the process of self-management. Our goal was to synthesise evidence for telehealth-supported self-management of diabetes (types 1 and 2), heart failure, asthma, chronic obstructive pulmonary disease (COPD) and cancer to identify components of effective self-management support. We performed a metareview (a systematic review of systematic reviews) of randomized controlled trials (RCTs) of telehealth interventions to support self-management in 6 exemplar long-term conditions. We searched 7 databases for reviews published from January 2000 to May 2016 and screened identified studies against eligibility criteria. We weighted reviews by quality (revised A Measurement Tool to Assess Systematic Reviews), size, and relevance. We then combined our results in a narrative synthesis and using harvest plots. We included 53 systematic reviews, comprising 232 unique RCTs. Reviews concerned diabetes (type 1: n=6; type 2, n=11; mixed, n=19), heart failure (n=9), asthma (n=8), COPD (n=8), and cancer (n=3). Findings varied between and within disease areas. The highest-weighted reviews showed that blood glucose telemonitoring with feedback and some educational and lifestyle interventions improved glycemic control in type 2, but not type 1, diabetes, and that telemonitoring and telephone interventions reduced mortality and hospital admissions in heart failure, but these findings were not consistent in all reviews. Results for the other conditions were mixed, although no reviews showed evidence of harm. Analysis of the mediating role of self-management, and of components of successful
Sleep-related problems in common medical conditions.

Science.gov (United States)

Parish, James M

2009-02-01

Common medical problems are often associated with abnormalities of sleep. Patients with chronic medical disorders often have fewer hours of sleep and less restorative sleep compared to healthy individuals, and this poor sleep may worsen the subjective symptoms of the disorder. Individuals with lung disease often have disturbed sleep related to oxygen desaturations, coughing, or dyspnea. Both obstructive lung disease and restrictive lung diseases are associated with poor quality sleep. Awakenings from sleep are common in untreated or undertreated asthma, and cause sleep disruption. Gastroesophageal reflux is a major cause of disrupted sleep due to awakenings from heartburn, dyspepsia, acid brash, coughing, or choking. Patients with chronic renal disease commonly have sleep complaints often due to insomnia, insufficient sleep, sleep apnea, or restless legs syndrome. Complaints related to sleep are very common in patients with fibromyalgia and other causes of chronic pain. Sleep disruption increases the sensation of pain and decreases quality of life. Patients with infectious diseases, including acute viral illnesses, HIV-related disease, and Lyme disease, may have significant problems with insomnia and hypersomnolence. Women with menopause have from insomnia, sleep-disordered breathing, restless legs syndrome, or fibromyalgia. Patients with cancer or receiving cancer therapy are often bothered by insomnia or other sleep disturbances that affect quality of life and daytime energy. The objective of this article is to review frequently encountered medical conditions and examine their impact on sleep, and to review frequent sleep-related problems associated with these common medical conditions.
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions.

Science.gov (United States)

Smolensky, Michael H; Portaluppi, Francesco; Manfredini, Roberto; Hermida, Ramon C; Tiseo, Ruana; Sackett-Lundeen, Linda L; Haus, Erhard L

2015-06-01

The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, Parkinson's and Alzheimer's disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot ulcer, tooth caries, burning mouth and temporomandibular syndromes, fibromyalgia, sciatica, intervertebral vacuum phenomenon, multiple sclerosis muscle spasm, and migraine, tension, cluster, hypnic, and paroxysmal hemicranial headache); renal: colic and nocturnal enuresis and polyuria; ocular: bulbar conjunctival redness, keratoconjunctivitis sicca, intraocular pressure and anterior ischemic optic neuropathy, and recurrent corneal erosion syndrome; psychiatric/behavioral: major and seasonal affective depressive disorders, bipolar disorder, parasuicide and suicide, dementia-associated agitation, and addictive alcohol, tobacco, and heroin cravings and withdrawal phenomena; plus autoimmune and musculoskeletal: rheumatoid arthritis, osteoarthritis, axial spondylarthritis, gout, Sjögren's syndrome, and systemic lupus erythematosus. Knowledge of these and other 24 h patterns of human pathophysiology informs research of their underlying circadian and other endogenous mechanisms, external temporal triggers, and more effective patient care entailing clinical chronopreventive and chronotherapeutic strategies. Copyright © 2014 Elsevier Ltd. All rights reserved.
Ollier disease

Directory of Open Access Journals (Sweden)

Jüppner Harald

2006-09-01

Full Text Available Abstract Enchondromas are common intraosseous, usually benign cartilaginous tumors, that develop in close proximity to growth plate cartilage. When multiple enchondromas are present, the condition is called enchondromatosis also known as Ollier disease (WHO terminology. The estimated prevalence of Ollier disease is 1/100,000. Clinical manifestations often appear in the first decade of life. Ollier disease is characterized by an asymmetric distribution of cartilage lesions and these can be extremely variable (in terms of size, number, location, evolution of enchondromas, age of onset and of diagnosis, requirement for surgery. Clinical problems caused by enchondromas include skeletal deformities, limb-length discrepancy, and the potential risk for malignant change to chondrosarcoma. The condition in which multiple enchondromatosis is associated with soft tissue hemangiomas is known as Maffucci syndrome. Until now both Ollier disease and Maffucci syndrome have only occurred in isolated patients and not familial. It remains uncertain whether the disorder is caused by a single gene defect or by combinations of (germ-line and/or somatic mutations. The diagnosis is based on clinical and conventional radiological evaluations. Histological analysis has a limited role and is mainly used if malignancy is suspected. There is no medical treatment for enchondromatosis. Surgery is indicated in case of complications (pathological fractures, growth defect, malignant transformation. The prognosis for Ollier disease is difficult to assess. As is generally the case, forms with an early onset appear more severe. Enchondromas in Ollier disease present a risk of malignant transformation of enchondromas into chondrosarcomas.
Hib Disease (Haemophilus Influenzae Type b)

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... Fitness Diseases & Conditions Infections Drugs & Alcohol School & Jobs Sports Expert Answers (Q&A) Staying Safe Videos for Educators Search English Español Hib Disease (Haemophilus Influenzae Type b) KidsHealth / For Teens / Hib Disease (Haemophilus Influenzae ...
Systemic diseases and the elderly.

LENUS (Irish Health Repository)

McCreary, Christine

2010-11-01

Although systemic diseases can occur at any age, they are more common in older patients. Accurate and detailed medical and drug histories are important in dental practice as many conditions and medications can influence oral health and dental care in patients. Not only can these conditions influence patient care in the surgery and oral hygiene at home, but access to dental services may also be adversely affected. Clinical Relevance: The systemic diseases can impact upon oral care or can have oral manifestations. Many of the pharmacological interventions prescribed for chronic conditions can have multiple and diverse adverse effects on the oral environment.
Management of adynamic bone disease in chronic kidney disease: A brief review

Directory of Open Access Journals (Sweden)

Swathi K. Sista

2016-09-01

Full Text Available The Kidney Disease: Improving Global Outcomes (KDIGO work group released recommendations in 2006 to define the bone-related pathology associated with chronic kidney disease as renal osteodystrophy. In 2009, KDIGO released revised clinical practice guidelines which redefined systemic disorders of bone and mineral metabolism due to chronic kidney disease as chronic kidney disease-mineral and bone disorders. Conditions under this overarching term include osteitis fibrosa cystica, osteomalacia, and adynamic bone disease. We aim to provide a brief review of the histopathology, pathophysiology, epidemiology, and diagnostic features of adynamic bone disease, focusing on current trends in the management of this complex bone disorder.

Dent disease

Directory of Open Access Journals (Sweden)

Rina R Rus

2017-04-01

Full Text Available Dent disease is an x-linked disorder of proximal renal tubular dysfunction that occurs almost exclusively in males. It is characterized by significant, mostly low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and chronic kidney disease. Signs and symptoms of this condition appear in early childhood and worsen over time. There are two forms of Dent disease, which are distinguished by their genetic cause and pattern of signs and symptoms (type 1 and type 2. Dent disease 2 is characterized by the features described above and also associated with extrarenal abnormalities (they include mild intellectual disability, hypotonia, and cataract. Some researchers consider Dent disease 2 to be a mild variant of a similar disorder called Lowe syndrome.We represent a case of a 3-year old boy with significant proteinuria in the nephrotic range and hypercalciuria. We confirmed Dent disease type 1 by genetic analysis.
Screening for peripheral arterial disease

African Journals Online (AJOL)

2014-02-01

Feb 1, 2014 ... effective, the disease process or condition ... clinical classification the Fontaine or ... aimed at curbing the socio-economic burden of atherosclerotic disease and its consequences in .... recommend smoking cessation, lipid.
Cardiovascular Disease and Chronic Inflammation in End Stage Kidney Disease

Directory of Open Access Journals (Sweden)

Sofia Zyga

2013-01-01

Full Text Available Background: Chronic Kidney Disease (CKD is one of the most severe diseases worldwide. In patients affected by CKD, a progressive destruction of the nephrons is observed not only in structuralbut also in functional level. Atherosclerosis is a progressive disease of large and medium-sized arteries. It is characterized by the deposition of lipids and fibrous elements and is a common complication of the uremic syndrome because of the coexistence of a wide range of risk factors. High blood pressure, anaemia, insulin resistance, inflammation, high oxidative stress are some of the most common factors that cause cardiovascular disease and atherogenesis in patients suffering from End Stage Kidney Disease (ESRD. At the same time, the inflammatory process constitutes a common element in the apparition and development of CKD. A wide range of possible causes can justify the development of inflammation under uremic conditions. Such causes are oxidative stress, oxidation, coexistentpathological conditions as well as factors that are due to renal clearance techniques. Patients in ESRD and coronary disease usually show increased acute phase products. Pre-inflammatory cytokines, such as IL-6 and TNF-a, and acute phase reactants, such as CRP and fibrinogen, are closely related. The treatment of chronic inflammation in CKD is of high importance for the development ofthe disease as well as for the treatment of cardiovascular morbidity.Conclusions: The treatment factors focus on the use of renin-angiotensic system inhibitors, acetylsalicylic acid, statins and anti-oxidant treatment in order to prevent the action of inflammatorycytokines that have the ability to activate the mechanisms of inflammation.
76 FR 35866 - Sunshine Act Meeting Notice

Science.gov (United States)

2011-06-20

... SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: Nelson Hastings, NIST Voting... issues. The full meeting agenda will be posted in advance at http://vote.nist.gov . All sessions of this... disability accommodation, such as the need for Sign Language Interpretation, please contact Nelson Hastings...
Two new species of sympatric Fergusonina flies (Diptera: Fergusoninidae) from bud galls on high elevation snow gums (Eucalyptus pauciflora Sieb. ex Spreng. complex) in the Australian Alps

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Two species of Fergusonina Malloch fly, F. daviesae Nelson sp.n. and F. taylori Nelson sp.n. (Diptera: Fergusoninidae), are described from terminal leaf bud galls on high elevation snow gums (Eucalyptus pauciflora complex) in the Australian Alps. These species occur in sympatry at the six locations...
Returning Images: Mandela, Marikana and the Rugged Road to the Future

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Annalisa Oboe

2014-11-01

Full Text Available It is only appropriate to begin with his face. The intense, rainbow-colored Mandela portrait that opens this issue is the work of a young Indonesian digital artist, Ihsanulhakim, who captures a serious, reflective and aged version of the South African leader. The writing on the top left of the image is a quote from Mandela’s famous reflection on death translated into Indonesian: “Death is something inevitable. When a man has done what he considers to be his duty to his people and his country, he can rest in peace”.[1] [1] RIP Nelson Mandela © Muhammad Ihsanulhakim. I wish to thank the artist for generously allowing Altre Modernità to reproduce his work. The quote is from an interview for the documentary “Mandela”, 1994, in Nelson Mandela by Himself: The Authorised Book of Quotations © 2010 by Nelson R. Mandela and The Nelson Mandela Foundation.
Gingival condition of patient with obesity

Directory of Open Access Journals (Sweden)

Atikah Sabrina Alyani

2018-01-01

Full Text Available The prevalence of obesity has increased drastically in most developed countries. Many studies showed that obesity associated with oral diseases, especially periodontal disease. A recent study showed the relation between WC and periodontal disease counted by gingival index (GI. However, studies regarding the mechanism of the relationship between obesity and periodontal disease are still quite a few, whereas many studies conducted suggested that obesity was a medical problem. The study was aimed to know and assess the gingival condition of obese people who visited the Dental Polyclinic of Hasan Sadikin Hospital. The type of this study was descriptive with the survey technique. A total of 54 people consisted of 35 female and 19 male patients with the age range of 20-49 years old, and not using any dental prosthesis or orthodontic appliance. This study was using a questionnaire and clinical examination to assess the condition of the gingival using the Löe and Silness Gingival index (GI. Examination of obesity conducted by measuring the waist circumference with criteria from WHO. The average value of the gingival index was 1.22. Meanwhile, the average value of the waist circumference (WC was 95.89 cm and 107.74 cm consecutively for female and male. The majority of obese patients suffered moderate gingivitis.
Periodontal Disease and Systemic Health

Science.gov (United States)

... Club Program Perio Store Education & Careers Careers in Periodontics Perio Exam for Dental Licensure Recommended Competencies Periodontal ... may also help with the management of other chronic inflammatory conditions. Diabetes heart Disease Other Diseases Members ...
Potential of Epigenetic Therapies in Non-cancerous Conditions

Directory of Open Access Journals (Sweden)

Raymond eYung

2014-12-01

Full Text Available There has been an explosion of knowledge in the epigenetics field in the past 20 years. The first epigenetic therapies have arrived in the clinic for cancer treatments. In contrast, much of the promise of epigenetic therapies for non-cancerous conditions remains in the laboratories. The current review will focus on the recent progress that has been made in understanding the pathogenic role of epigenetics in immune and inflammatory conditions, and how the knowledge may provide much needed new therapeutic targets for many autoimmune diseases. Dietary factors are increasingly recognized as potential modifiers of epigenetic marks that can influence health and diseases across generations. The current epigenomics revolution will almost certainly complement the explosion of personal genetics medicine to help guide treatment decisions and disease risk stratification.
Personal life and working conditions of trainees and young specialists in clinical microbiology and infectious diseases in Europe: a questionnaire survey.

Science.gov (United States)

Maraolo, A E; Ong, D S Y; Cortez, J; Dedić, K; Dušek, D; Martin-Quiros, A; Maver, P J; Skevaki, C; Yusuf, E; Poljak, M; Sanguinetti, M; Tacconelli, E

2017-07-01

The purpose of this investigation was to assess the balance between the personal and professional lives of trainees and young European specialists in clinical microbiology (CM) and infectious diseases (ID), and determine differences according to gender, country of training, workplace and specialty. The Steering Committee of the Trainee Association of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) devised a questionnaire survey consisting, beyond the demographic questions, of nine yes/no questions, 11 Likert scale self-evaluations and one open-response item on parenthood, working conditions, quality of life, alcohol consumption and burnout. This anonymous survey in English was held between April and July 2015 among European CM/ID trainees and young specialists (mothers enjoyed the benefit of working hours flexibility. Only two-thirds of respondents found their working environment stimulating. In comparison to colleagues from other parts of Europe, trainees and young specialists from Southern/Eastern Europe (SEE) had less frequent regular meetings with mentors/supervisors and head of departments where trainees' issues are discussed. Also, physicians from SEE were more frequently victims of workplace mobbing/bullying in comparison to those from other regions. Finally, multivariate analysis showed that female gender, SEE region and ID specialty were associated with burnout feelings. Female gender and country of work from SEE largely determine satisfactory working conditions, the possibility of parenthood leaves, amount of leisure time, mobbing experiences and burnout feelings among European CM/ID trainees and young specialists.
Systemic conditions affecting the breast

International Nuclear Information System (INIS)

Abbitt, P.L.; DeParedes, E.S.

1987-01-01

While the mammogram is most often used in the evaluation of diseases specific to the breast, manifestations of systemic conditions may also be recognized. Congenital systemic conditions such as neurofibromatosis and ectodermal dysplasia have graphic mammographic findings. The effects of diet, hormonal, and medication therapy can also have a dramatic impact on the appearance of the mammogram, as can common clinical states such as congestive heart failure or renal failure. Metastases to the breast from extramammary primaries may be seen mammographically as discrete masses, as causing diffusely increased density of the breast or as abnormal axillary adenopathy. The authors review a variety of conditions and their mammographic appearance
Genetics Home Reference: critical congenital heart disease

Science.gov (United States)

... Facebook Twitter Home Health Conditions Critical congenital heart disease Critical congenital heart disease Printable PDF Open All Close All ... for Disease Control and Prevention: Congenital Heart Defects Disease InfoSearch: Congenital Heart Defects KidsHealth from Nemours Lucile Packard Children's ...
Provision of antiretroviral therapy for children in Nelson Mandela Bay: Health care professionals’ challenges

Directory of Open Access Journals (Sweden)

Margaret Williams

2018-03-01

Conclusion: Capacitation of the health care system, integration of services, competent management and visionary leadership to invoke a collaborative interdisciplinary team approach is required to ensure that HIV is treated as a chronic disease at the PHC clinic level.
The Causal Mediation Formula - A Guide to the Assessment of Pathways and Mechanisms

Science.gov (United States)

2011-10-01

for estimating CDE(z) in observational studies (in the presence of unobserved confounders) can be derived using do- calculus (Pearl, 2009, pp. 85–88...2011; Albert and Nelson , 2011). 7In the presence of measured and unmeasured confounders, the general conditions under which NDE is estimable from...achieve this independence (see footnote 7), that Z may represent a vector of variables, and that integrals should replace summations when dealing with
75 FR 77858 - Sunshine Act Notice

Science.gov (United States)

2010-12-14

... this notice. FOR FURTHER INFORMATION CONTACT: Nelson Hastings, NIST Voting Program, Information... posted in advance at http://vote.nist.gov . All sessions of this meeting will be open to the public. A... for Sign Language Interpretation, please contact Nelson Hastings by c.o.b. Thursday, January 6, 2011...
Download this PDF file

African Journals Online (AJOL)

FEN

The African National Congress Youth League was formed in. 1948 followed by the adoption of the Youth League Programme of Action against the white led apartheid government. Nelson Madela was elected the. Secretary General of this Youth league. This position attracted wide publicity to Nelson Mandela especially with ...
Studies in Intelligence. Volume 55, Number 3

Science.gov (United States)

2011-09-01

terrelationships and conflicts. This makes for slow reading, but the coverage is thorough. With the release of Nelson Mandela and the end of...Lies, and Bureaucratic Bungling Inside the FBI (Nashville, TN: Nelson Cur- rent, 2004); Dan Stober and Ian Hoffman, A Convenient Spy: Wen Ho Lee and the
Application of commutator theorems to the integration of representations of Lie algebras and commutation relations

International Nuclear Information System (INIS)

Froehlich, J.

1977-01-01

Sufficient conditions on unbounded, symmetric operators A and B which imply that exp(itA)exp(isB)exp(-itA) satisfies the well known 'multiple commutator' formula are derived. This formula is then applied to prove new necessary and sufficient conditions for the integrability of representations of Lie algebras and canonical commutation relations and the commutativity of the spectral projections of two commuting, unbounded, self-adjoint operators. A classic theorem of Nelson's is obtained as a corollary. Our results are useful in relativistic quantum field theory. (orig.) [de
Defining and Measuring Chronic Conditions

Centers for Disease Control (CDC) Podcasts

This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States.
Role of genetic in periodontal disease

Directory of Open Access Journals (Sweden)

Anand Narayanrao Wankhede

2017-01-01

Full Text Available Genetics is the study and understanding of the phenomena of heredity and variation. A large number of genes are associated with many systemic conditions. Periodontitis is inflammatory condition of periodontium. Periodontium consists of gingiva, periodontal ligament, cementum, and alveolar bone. It is considered being a multifactorial disease. Studies of animals and humans support the concept that a large number of genes' factor may be associated with periodontitis and clearly play a role in the predisposition and progression of periodontal diseases. It has been proven that genetic factors impair inflammatory and immune responses during periodontal diseases. Research on identifying specific genes causing periodontitis may improve and prevent the disease progression. The aim of this article is to focus on genetic risk factors and its influence for the various forms of periodontal disease.

Homosexual Identity in Alex Sanchez's 'Rainbow Trilogy'

Directory of Open Access Journals (Sweden)

Nanda Vidyastria

2017-03-01

Full Text Available This research aims at describing 1 stages of homosexual identity development in three main characters in the Rainbow Trilogy using Cass model, 2 factors influencing the development of homosexual identity using D Augellis theory, and 3 forms of victimization towards homosexuals experienced by the main characters using theories of D Augelli and Rivers. Queer studies was applied to describe and analyze the data in forms of words, phrases, sentences, statements, dialogues as well as monologues in the Rainbow Trilogy, recording thoughts and actions by the characters in accordance with the research focus. As a result, the research finds out that the three novels describe clearly all stages of Cass model of homosexual identity development in Jason and Kyle, including their identity confusions, comparisons, acceptances, tolerances, prides and syntheses. In Nelson, only one stage that can be identified as Nelson is described as one whose sexual identity has been formed. The research also reveals how factors of personal subjectivity and action, interactive intimacy and sociohistorical connection are connected to each others and also influencing the homosexual identity developments of the main characters. Besides, the research also shows that various kinds of victimization occur to Jason, Kyle and Nelson. Normative victimizations made to feel different are experienced by Nelson and Kyle. Family stressor and prejudices in connection to AIDS are experienced by the three characters. Victimization of direct attacks in forms of verbal and physical abuses are experienced by Kyle and Nelson. Lastly, the research finds out that Nelson is the only character experiencing sexual abuse. It occurs in form of undesired comments oriented to a sexual violence.
Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease.

Science.gov (United States)

Mita, Tsuneyuki; Furukawa-Hibi, Yoko; Takeuchi, Hideyuki; Hattori, Hisashi; Yamada, Kiyofumi; Hibi, Hideharu; Ueda, Minoru; Yamamoto, Akihito

2015-10-15

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by a decline in cognitive abilities and the appearance of β-amyloid plaques in the brain. Although the pathogenic mechanisms associated with AD are not fully understood, activated microglia releasing various neurotoxic factors, including pro-inflammatory cytokines and oxidative stress mediators, appear to play major roles. Here, we investigated the therapeutic benefits of a serum-free conditioned medium (CM) derived from the stem cells of human exfoliated deciduous teeth (SHEDs) in a mouse model of AD. The intranasal administration of SHEDs in these mice resulted in substantially improved cognitive function. SHED-CM contained factors involved in multiple neuroregenerative mechanisms, such as neuroprotection, axonal elongation, neurotransmission, the suppression of inflammation, and microglial regulation. Notably, SHED-CM attenuated the pro-inflammatory responses induced by β-amyloid plaques, and generated an anti-inflammatory/tissue-regenerating environment, which was accompanied by the induction of anti-inflammatory M2-like microglia. Our data suggest that SHED-CM may provide significant therapeutic benefits for AD. Copyright © 2015 Elsevier B.V. All rights reserved.
Long-term results of radiotherapy in the treatment of pituitary adenomas in children and adolescents

International Nuclear Information System (INIS)

Grigsby, P.W.; Thomas, P.R.; Simpson, J.R.; Fineberg, B.B.

1988-01-01

A retrospective review was performed of 11 children and adolescents (less than 19 years of age) with diagnosed pituitary adenomas. The patients were treated with subtotal resection and postoperative irradiation (S + R) or with irradiation alone (RT) at the Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University Medical Center, from January 1958 through December 1982. Patient conditions at diagnosis were acromegaly in one, Nelson's syndrome in one, prolactinoma in three, chromophobe adenoma in three, and Cushing's disease in three. Median follow-up was 15.6 years (range 6.3-29.5 years). Only two patients have had failure: one at 8.6 years and the other at 20.7 years following treatment. All four patients with visual field (VF) defects at diagnosis underwent S + R, with only one developing recurrent disease. The remaining seven patients, who did not have VF defects, received RT only, and there has been one failure in this group. None have suffered long-term visual complications. All have been able to continue school and/or work. Three of eight females have borne children. Hypopituitarism requiring medication occurred in all who received S + R and in four of seven who received RT only
Systemic conditions and treatments as risk for therapy with dental implants

International Nuclear Information System (INIS)

Arguedas Vega, Natalia; Alfaro Mayorga, Erika

2013-01-01

The possible risks for osseointegration are described in patients with specific systemic conditions, medical treatment such as radiation, cardiovascular diseases, HIV and smoking habit. The principal complications for osseointegration of diseases and systemic treatments are exposed. The review and search of the available literature are realized in databases. The scientific literature obtained from human studies has reported the survival of patients with dental implants. The implants are placed in patients with at least one of the conditions studied. The risks of the surgical procedures required for the placement of implants are analyzed in systemically compromised patients. Comparisons of patients with and without systemic conditions in controlled form have remained without analyzing. The level of evidence of absolute and relative contraindications has been low for the therapy with implants in patients with systemic diseases. The revised information is detailed according the systemic conditions, and each of them are evaluated separately [es
Operating a sustainable disease management program for chronic obstructive pulmonary disease.

Science.gov (United States)

Endicott, Linda; Corsello, Phillip; Prinzi, Michele; Tinkelman, David G; Schwartz, Abby

2003-01-01

Chronic obstructive pulmonary disease (COPD) is one of our nation's most rapidly growing chronic health conditions. It is estimated that over 16 million individuals are diagnosed with COPD (Friedman & Hilleman, 2001). In addition, another 16 million are misdiagnosed as asthma or not diagnosed at all. COPD is a condition that affects the working-age as well as the elderly. Despite the high mortality rate, COPD is a treatable and modifiable condition. Disease management programs (DMPs) for asthma are a common initiative within many health insurance plans and integrated delivery networks. Similar initiatives are not as common for COPD. This article will highlight the National Jewish Medical and Research Center's COPD DMP interventions and outcomes. To outline interventions and operational strategies critical in developing and operating a sustainable and effective disease management program for COPD. Disease Management is an effective model for managing individuals with COPD. Applying a case management model that includes (1) risk-identification and stratification; (2) education and empowerment regarding self-monitoring and management; (3) lifestyle modification; (4) communication and collaboration amongst patients, healthcare providers, and case managers to enhance the treatment plan; (5) providing after-hours support; and (6) monitoring care outcomes is crucial. Applying these interventions in a credible manner will improve the quality of life and quality of care delivered to individuals with mild, moderate, severe, and very severe COPD. Additionally, these interventions can significantly reduce utilization events.
Retinal Diseases

Science.gov (United States)

... Linked Retinoschisis (XLRS) X-Linked Retinitis Pigmentosa (XLRP) Usher Syndrome Other Retinal Diseases Glossary News & Research News & Research ... central portion of the retina called the macula. Usher Syndrome Usher syndrome is an inherited condition characterized by ...
Hypertension, obesity, and coronary artery disease in the survivors of congenital heart disease.

Science.gov (United States)

Roche, S Lucy; Silversides, Candice K

2013-07-01

Obesity, hypertension, and coronary artery disease are prevalent in the general population and well recognized as contributors to cardiac morbidity and mortality. With surgical and medical advances, there is a growing and aging population with congenital heart disease who are also at risk of developing these comorbidities. In addition, some congenital cardiac lesions predispose patients to conditions such as hypertension or coronary artery disease. The effect of these comorbidities on the structurally abnormal heart is not well understood, but might be very important, especially in those with residual abnormalities. Thus, in addition to surveillance for and treatment of late complications it is important for the congenital cardiologist to consider and aggressively manage acquired comorbidities. In this review we explore the prevalence of hypertension, obesity, and coronary artery disease, discuss congenital lesions that predispose to these conditions and review management strategies for this unique population. Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Forced convection of ammonia. Liquid ammonia. Case of large wall to fluid temperature differences; Convection forcee de l'ammoniac. Premiere partie. Ammoniac liquide. Cas de grands ecarts de temperatures entre fluide et paroi

Energy Technology Data Exchange (ETDEWEB)

Perroud, P; Rebiere, J; Rowe, A [Commissariat a l' Energie Atomique, 38 - Grenoble (France). Centre d' Etudes Nucleaires

1967-07-01

Two test tubes were used: Inconel (ID 3 mm, OD 3.5 mn length 300 mm) and tantalum (ID 3 mm, OD 4 mm; length 450 mm). Measurements were performed in the following conditions inlet temperature of subcooled liquid from +4 deg C to + 54 deg C; inlet pressure from 10 to 42, bars; mass velocity from 33 to 243 g/cm{sup 2}.s; maximum heat flux 583 W/cm{sup 2}; maximum wall temperature 1523 deg C; steam quality reaching 1. When the flow is liquid, a film of vapor is formed on the heated wall. Using the Martinelli-Nelson parameter X{sub tt} a correlation of the heat transfer coefficients is presented in the two-phase region. This correlation is analogous to the one developed for liquid hydrogen. In the gaseous phase region the correlation established is: N{sub u} 0.0046 R{sub e}{sup 0.95} P{sub r}{sup 0.4} with a film temperature of t{sub 0.5}. The Martinelli-Nelson method gives fairly good results for pressure drop evaluation. Gross experimental results are published separately. (authors) [French] Deux tubes d'essais ont ete utilises: inconel (diametre 3 x 3,5 mm; longueur 300 mm) et tantale (diametre 3 x 4 mm; longueur 450 mm). Les mesures ont ete effectuees dans les conditions suivantes: temperature d'entree du liquide sous-refroidi, + 4 deg C a + 54 deg C; pression d'entree, 10 a 42 bars; vitesse massique, 33 a 243 g/cm{sup 2}.s; densite de flux de chaleur maximum 583 W/cm{sup 2}; temperature maximale de la paroi: 1523 deg C; titre de vapeur atteignant 1. Quand l'ecoulement est liquide, il se forme un film de vapeur sur la paroi. En double-phase on a etabli une correlation des coefficients d'echanges, utilisant le parametre de Martinelli et Nelson X{sub tt}, analogue a celle obtenue pour l'hydrogene liquide. En phase gazeuse la correlation presentee est: N{sub u} = 0,0046 R{sub e}{sup 0,95} P{sub r}{sup 0,4} avec une temperature de film de t{sub 0,5}. La methode de Martinelli et Nelson donne d'assez bons resultats pour le calcul des pertes de charge. Les resultats
Chronic obstructive pulmonary disease and chronic heart failure: two muscle diseases?

Science.gov (United States)

Troosters, Thierry; Gosselink, Rik; Decramer, Marc

2004-01-01

Chronic obstructive pulmonary disease and congestive heart failure are two increasingly prevalent chronic diseases. Although care for these patients often is provided by different clinical teams, both disease conditions have much in common. In recent decades, more knowledge about the systemic impact of both diseases has become available, highlighting remarkable similarities in terms of prognostic factors and disease management. Rehabilitation programs deal with the systemic consequences of both diseases. Although clinical research also is conducted by various researchers investigating chronic obstructive pulmonary disease and chronic heart failure, it is worthwhile to compare the progress in relation to these two diseases over recent decades. Such comparison, the purpose of the current review, may help clinicians and scientists to learn about progress made in different, yet related, fields. The current review focuses on the similarities observed in the clinical impact of muscle weakness, the mechanisms of muscle dysfunction, the strategies to improve muscle function, and the effects of exercise training on chronic obstructive pulmonary disease and chronic heart failure.
Multiple chronic conditions and life expectancy

DEFF Research Database (Denmark)

DuGoff, Eva H; Canudas-Romo, Vladimir; Buttorff, Christine

2014-01-01

BACKGROUND: The number of people living with multiple chronic conditions is increasing, but we know little about the impact of multimorbidity on life expectancy. OBJECTIVE: We analyze life expectancy in Medicare beneficiaries by number of chronic conditions. RESEARCH DESIGN: A retrospective cohort...... study using single-decrement period life tables. SUBJECTS: Medicare fee-for-service beneficiaries (N=1,372,272) aged 67 and older as of January 1, 2008. MEASURES: Our primary outcome measure is life expectancy. We categorize study subjects by sex, race, selected chronic conditions (heart disease, cancer...... and increasing numbers of comorbid conditions. CONCLUSIONS: Social Security and Medicare actuaries should account for the growing number of beneficiaries with multiple chronic conditions when determining population projections and trust fund solvency....
Occupational diseases of dust etiology

International Nuclear Information System (INIS)

Sokolik, L.I.; Shkondin, A.N.

1981-01-01

Detailed etiologic and clinico-roentgenological characteristics of pneumoconiosis, as widely spread occupational disease caused by different kinds of dust, are given. The course of pneumoconiosis is discussed depending on working conditions of patients after the disease had been ascertained, as well as its complications, taking into account roentgeno-morphological types of fibrosis and the stages of the disease [ru
76 FR 16806 - Notice of Intent To Prepare an Environmental Impact Statement and Environmental Impact Report for...

Science.gov (United States)

2011-03-25

... in advance through local media, newspapers and the BLM Web site at: http://www.blm.gov/ca/st/en/fo...: Casa Diablo IV Development Project, C/O Steven Nelson, Project Manager. Documents pertinent to this... National Forest, telephone (760) 873- 2424; or mail to: Steven Nelson, Project Manager, BLM [[Page 16807...
Leprosy-related mortality in Brazil: a neglected condition of a neglected disease.

Science.gov (United States)

Martins-Melo, Francisco Rogerlândio; Assunção-Ramos, Adriana Valéria; Ramos, Alberto Novaes; Alencar, Carlos Henrique; Montenegro, Renan Magalhães; Wand-Del-Rey de Oliveira, Maria Leide; Heukelbach, Jorg

2015-10-01

Leprosy is a public health problem and a neglected condition of morbidity and mortality in several countries of the world. We analysed time trends and spatiotemporal patterns of leprosy-related mortality in Brazil. We performed a nationwide population-based study using secondary mortality data. We included all deaths that occurred in Brazil between 2000 and 2011, in which leprosy was mentioned in any field of death certificates. Leprosy was identified in 7732/12 491 280 deaths (0.1%). Average annual age-adjusted mortality rate was 0.43 deaths/100 000 inhabitants (95% CI 0.40-0.46). The burden of leprosy deaths was higher among males, elderly, black race/colour and in leprosy-endemic regions. Lepromatous leprosy was the most common clinical form mentioned. Mortality rates showed a significant nationwide decrease over the period (annual percent change [APC]: -2.8%; 95% CI -4.2 to -2.4). We observed decreasing mortality rates in the South, Southeast and Central-West regions, while the rates remained stable in North and Northeast regions. Spatial and spatiotemporal high-risk clusters for leprosy-related deaths were distributed mainly in highly endemic and socio-economically deprived regions. Leprosy is a neglected cause of death in Brazil since the disease is preventable, and a cost-effective treatment is available. Sustainable control measures should include appropriate management and systematic monitoring of leprosy-related complications, such as severe leprosy reactions and adverse effects to multidrug therapy. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Grape Cultivar and Sap Culture Conditions Affect the Development of Xylella fastidiosa Phenotypes Associated with Pierce's Disease.

Science.gov (United States)

Hao, Lingyun; Zaini, Paulo A; Hoch, Harvey C; Burr, Thomas J; Mowery, Patricia

2016-01-01

Xylella fastidiosa is a xylem-limited bacterium in plant hosts and causes Pierce's disease (PD) of grapevines, which differ in susceptibility according to the Vitis species (spp.). In this work we compared X. fastidiosa biofilm formation and population dynamics when cultured in xylem saps from PD-susceptible and -resistant Vitis spp. under different conditions. Behaviors in a closed-culture system were compared to those in different sap-renewal cultures that would more closely mimic the physicochemical environment encountered in planta. Significant differences in biofilm formation and growth in saps from PD-susceptible and -resistant spp. were only observed using sap renewal culture. Compared to saps from susceptible V. vinifera, those from PD-resistant V. aestivalis supported lower titers of X. fastidiosa and less biofilm and V. champinii suppressed both growth and biofilm formation, behaviors which are correlated with disease susceptibility. Furthermore, in microfluidic chambers X. fastidiosa formed thick mature biofilm with three-dimensional (3-D) structures, such as pillars and mounds, in saps from all susceptible spp. In contrast, only small aggregates of various shapes were formed in saps from four out of five of the resistant spp.; sap from the resistant spp. V. mustangensis was an exception in that it also supported thick lawns of biofilm but not the above described 3-D structures typically seen in a mature biofilm from the susceptible saps. Our findings provide not only critical technical information for future bioassays, but also suggest further understanding of PD susceptibility.
Grape Cultivar and Sap Culture Conditions Affect the Development of Xylella fastidiosa Phenotypes Associated with Pierce's Disease

Science.gov (United States)

Hoch, Harvey C.; Burr, Thomas J.; Mowery, Patricia

2016-01-01

Xylella fastidiosa is a xylem-limited bacterium in plant hosts and causes Pierce’s disease (PD) of grapevines, which differ in susceptibility according to the Vitis species (spp.). In this work we compared X. fastidiosa biofilm formation and population dynamics when cultured in xylem saps from PD-susceptible and -resistant Vitis spp. under different conditions. Behaviors in a closed-culture system were compared to those in different sap-renewal cultures that would more closely mimic the physicochemical environment encountered in planta. Significant differences in biofilm formation and growth in saps from PD-susceptible and -resistant spp. were only observed using sap renewal culture. Compared to saps from susceptible V. vinifera, those from PD-resistant V. aestivalis supported lower titers of X. fastidiosa and less biofilm and V. champinii suppressed both growth and biofilm formation, behaviors which are correlated with disease susceptibility. Furthermore, in microfluidic chambers X. fastidiosa formed thick mature biofilm with three-dimensional (3-D) structures, such as pillars and mounds, in saps from all susceptible spp. In contrast, only small aggregates of various shapes were formed in saps from four out of five of the resistant spp.; sap from the resistant spp. V. mustangensis was an exception in that it also supported thick lawns of biofilm but not the above described 3-D structures typically seen in a mature biofilm from the susceptible saps. Our findings provide not only critical technical information for future bioassays, but also suggest further understanding of PD susceptibility. PMID:27508296
Grape Cultivar and Sap Culture Conditions Affect the Development of Xylella fastidiosa Phenotypes Associated with Pierce's Disease.

Directory of Open Access Journals (Sweden)

Lingyun Hao

Full Text Available Xylella fastidiosa is a xylem-limited bacterium in plant hosts and causes Pierce's disease (PD of grapevines, which differ in susceptibility according to the Vitis species (spp.. In this work we compared X. fastidiosa biofilm formation and population dynamics when cultured in xylem saps from PD-susceptible and -resistant Vitis spp. under different conditions. Behaviors in a closed-culture system were compared to those in different sap-renewal cultures that would more closely mimic the physicochemical environment encountered in planta. Significant differences in biofilm formation and growth in saps from PD-susceptible and -resistant spp. were only observed using sap renewal culture. Compared to saps from susceptible V. vinifera, those from PD-resistant V. aestivalis supported lower titers of X. fastidiosa and less biofilm and V. champinii suppressed both growth and biofilm formation, behaviors which are correlated with disease susceptibility. Furthermore, in microfluidic chambers X. fastidiosa formed thick mature biofilm with three-dimensional (3-D structures, such as pillars and mounds, in saps from all susceptible spp. In contrast, only small aggregates of various shapes were formed in saps from four out of five of the resistant spp.; sap from the resistant spp. V. mustangensis was an exception in that it also supported thick lawns of biofilm but not the above described 3-D structures typically seen in a mature biofilm from the susceptible saps. Our findings provide not only critical technical information for future bioassays, but also suggest further understanding of PD susceptibility.
Addison's disease and its associations.

Science.gov (United States)

Puttanna, Amar; Cunningham, Alana Rosaleen; Dainty, Philip

2013-07-26

Addison's disease is a relatively rare endocrine condition resulting from adrenal insufficiency due to various causes. Weight loss is a common feature; however, patients may be seen by a variety of specialists, even requiring acute admission before the diagnosis is made. Addison's disease is commonly associated with other autoimmune diseases. In some cases such as autoimmune polyendocrine syndromes (APS) types 1 and 2, these associations are more commonly found. We present a case of one such patient who presented to the acute medical team having been referred to the gastrointestinal services in the previous year for persistent vomiting and weight loss. On review of history, the cause of vomiting and weight loss was questioned and combined with subsequent biochemical testing a diagnosis of Addison's disease was made. The patient was also noted to have other associated endocrine and autoimmune conditions.
[Autoimmune thyroid disease and other non-endocrine autoimmune diseases].

Science.gov (United States)

Dilas, Ljiljana Todorović; Icin, Tijana; Paro, Jovanka Novaković; Bajkin, Ivana

2011-01-01

Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. They constitute heterogeneous group of disorders, in which multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Recent epidemiological studies have shown a possible shift of one autoimmune disease to another or the fact that more than one autoimmune disease may coexist in a single patient or in the same family. Numerous autoimmune diseases have been shown to coexist frequently with thyroid autoimmune diseases. AUTOIMMNUNE THYROID DISEASE AND OTHER ORGAN SPECIFIC NON-ENDOCRINE AUTOIMMUNE DISEASES: This part of the study reviews the prevalence of autoimmune thyroid disease coexisting with: pernicious anaemia, vitiligo, celiac disease, autoimmune liver disease, miastenia gravis, alopecia areata and sclerosis multiplex, and several recommendations for screening have been given. AUTOIMMUNE THYROID DISEASE AND OTHER ORGAN NON-SPECIFIC NON-ENDOCRINE AUTOIMMUNE DISEASES: Special attention is given to the correlation between autoimmune thyroid disease and rheumatoid arthritis, systemic lupus erythematosus, syndrome Sjögren, systemic sclerosis and mixed connective tissue disease. Screening for autoimmune thyroid diseases should be recommended in everyday clinical practice, in patients with primary organ-specific or organ non-specific autoimmune disease. Otherwise, in patients with primary thyroid autoimmune disease, there is no good reason of seeking for all other autoimmune diseases, although these patients have a greater risk of developing other autoimmune disease. Economic aspects of medicine require further analyzing of these data, from cost/benefit point of view to justified either mandatory screening or medical practitioner judgment.
Kikuchi Fujimoto Disease

Directory of Open Access Journals (Sweden)

Al-Bishri Jamal

2012-01-01

Full Text Available In order to determine the clinical significance of Kikuchi Fujimoto Disease (histiocytic necrotizing lymhadenitis and to review the literature available on this condition, we selected the Medicine research papers in English language published between the years 1972 to 2011. Kikuchi Fujimoto Disease (KFD is an uncommon, cosmopolitan, benign and self-limiting condition with higher Japanese and Asian prevalence. Most of the sufferers of KFD are young people who seek treatment because of having acute tender cervical lymphadenopathy, low grade fever and night sweats. Coagulative necrosis with ample karyorrhetic debris in paracortical areas of the involved lymph nodes is the characteristic histologic feature of KFD. Diagnosing KFD is crucial as it can be mistaken for malignant lymphoma and SLE. KFD was put forth first time in 1972 by Dr. Masahiro Kikuchi and by Funimoto as lymphadenitis with reticular proliferation, histiocytes and abundant nuclear debris. It is a rare benign condition of lymph nodes and most of the clinicians and pathologists are unfamiliar with it. KFD is self-limiting disease (within 1 to 4 months, however, patients should be followed up regularly as it may crop up again or progress to SLE. Analgesics and antipyretics help to ameliorate the symptoms.
Crohn's disease in adolescence: presentation and treatment.

Science.gov (United States)

Cullen, Mick; Barnes, Claire

2015-05-13

Crohn's disease is a chronic inflammatory bowel condition that affects more than 115,000 people in the UK. This article focuses on Crohn's disease in adolescents. Management of the condition in this group should address adolescent-specific characteristics and treatment goals. Key elements include optimising growth, pubertal development and social functioning, including education. The condition can affect an individual's mental and emotional wellbeing significantly, as well as their physical health. As adolescence is a time of great change, the additional burden of a chronic illness can prove difficult to manage. The authors provide information on the presentation of Crohn's disease in adolescence and insights into the particular issues encountered by this group.

Identification of relevant ICF categories in patients with chronic health conditions: a Delphi exercise.

Science.gov (United States)

Weigl, Martin; Cieza, Alarcos; Andersen, Christina; Kollerits, Barbara; Amann, Edda; Stucki, Gerold

2004-07-01

To identify the most typical and relevant categories of the International Classification of Functioning, Disability and Health (ICF) for patients with low back pain, osteoporosis, rheumatoid arthritis, osteoarthritis, chronic generalized pain, stroke, depression, obesity, chronic ischaemic heart disease, obstructive pulmonary disease, diabetes mellitus, and breast cancer. An international expert survey using the Delphi technique was conducted. Data were collected in 3 rounds. Answers were linked to the ICF and analysed for the degree of consensus. Between 21 (osteoporosis, chronic ischaemic heart disease, and obstructive pulmonary disease) and 43 (stroke) experts responded in each of the conditions. In all conditions, with the exception of depression, there were categories in all ICF components that were considered typical and/or relevant by at least 80% of the responders. While all conditions had a distinct typical spectrum of relevant ICF categories, there were also some common relevant categories throughout the majority of conditions. Lists of ICF categories that are considered relevant and typical for specific conditions by international experts could be created. This is an important step towards identifying ICF Core Sets for chronic conditions.
[Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].

Science.gov (United States)

Richter, L; Rappersberger, K

2016-12-01

Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity. The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC). An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. CD and UC are frequently associated with mucocutaneous symptoms; however, primary/specific disease-associations are exclusively seen in CD patients. These include peri-anal and -stomal fistulas and ulcerations, "metastatic" Crohn's disease as well as oral granulomatous disease. Moreover, in both CD and UC, there occur several other inflammatory skin conditions such as erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa, chronic oral aphthous disease, Sweet syndrome, pyostomatitis vegetans, and bowel-associated dermatosis-arthritis syndrome. Malnutrition syndromes (zinc and vitamin deficiencies) are only rarely observed. On skin and oral/genital mucous membranes various different inflammatory manifestations may be observed during the course of CD or UC. However, most data about a direct pathogenic relationship of the gastrointestinal and dermatologic disorders are quite heterogeneous or even contradictory. Nevertheless, knowledge of these conditions and their possible association with CD and UC could be crucial for early diagnosis and initiation of an appropriate therapy and thus be essential to prevent secondary tissue damage.
Life on Mount Obstacle: Disease of existence as condition and possibility

DEFF Research Database (Denmark)

Aggerholm, Kenneth; Jespersen, Ejgil

will analyze various kinds of human meaning that can be found on Mount Obstacle, departing from two key positions: First, Camus (1967) used The Myth of Sisyphus to describe how the experience of obstacles is a human condition. In cases of disability this condition is of course more evident, but the task...... is still to create meaning from this absurd condition. Sisyphus is to Camus an ’absurd hero’ because he is aware of and acknowledges the challenge that he is condemned to. This means that the struggle to overcome the necessary obstacle can become a meaningful pursuit, wherefore Camus concluded: ”The...... be illustrated by Suits’ (2005) classical treatise on game playing. By choosing to climb Mount Obstacle the activity of climbing becomes an end in itself, which opens for experiencing the intrinsic value related to voluntarily attempting to overcome the unnecessary obstacle. In both cases life on Mount Obstacle...
Prospective surveillance of multivariate spatial disease data

Science.gov (United States)

Corberán-Vallet, A

2012-01-01

Surveillance systems are often focused on more than one disease within a predefined area. On those occasions when outbreaks of disease are likely to be correlated, the use of multivariate surveillance techniques integrating information from multiple diseases allows us to improve the sensitivity and timeliness of outbreak detection. In this article, we present an extension of the surveillance conditional predictive ordinate to monitor multivariate spatial disease data. The proposed surveillance technique, which is defined for each small area and time period as the conditional predictive distribution of those counts of disease higher than expected given the data observed up to the previous time period, alerts us to both small areas of increased disease incidence and the diseases causing the alarm within each area. We investigate its performance within the framework of Bayesian hierarchical Poisson models using a simulation study. An application to diseases of the respiratory system in South Carolina is finally presented. PMID:22534429
Anemia in Chronic Kidney Disease

Science.gov (United States)

... Cysts Solitary Kidney Your Kidneys & How They Work Anemia in Chronic Kidney Disease What is anemia? Anemia is a condition in which the body ... function as well as they should. How is anemia related to chronic kidney disease? Anemia commonly occurs ...
Evolution of the ICESIM model

International Nuclear Information System (INIS)

Carson, R.W.; Groeneveld, J.L.

1997-01-01

A computer model named ICESIM was developed by Acres International in 1973 to study river ice problems associated with the construction of the Limestone Hydroelectric Generating Station on the Nelson River. The program could numerically simulate the processes of river ice formation under steady state conditions of flow. The program has evolved over two decades and has been used as a design and analytical tool for several river ice problems. One of the shortcomings of the model was its inability to consider varying river flows during a simulation. The model has recently been restructured into a new version called ICEDYN which uses a hydrodynamic module to compute river hydraulics. The ICEDYN program uses the same approach as ICESIM, but river hydraulics, which are affected by changes in inflow, and the accumulation of ice, are computed through a hydrodynamic solution of the St. Venant Equations. The ICEDYN model requires an extensive data set to describe the particular river reach being simulated. It has been tested on the Nelson River in northern Manitoba to see whether the numerical methods in the model can successfully represent field conditions. Results were encouraging but additional refinement is still needed. 7 refs., 1 tab., 7 figs
Regional Seismic Arrays and Nuclear Test Ban Verification

Science.gov (United States)

1990-12-01

Anderson, K. R., S. T. Rosenberg, and D. Lanan (1982). Automatic association using expert system techniq:_,s, in Seismic Discrimination, Semiannual...Travel Times, Earthquake, by Glenn D. Nelson and John E. V idale . ........... ...................................... ............ . ....... 395 Lund...1553 Nelson, Glenn D. and John E. Vidale-Earthquake Locations by 3-D Finite Difference Travel Times
Acute abdominal conditions in people with sickle cell disease: A 10 ...

African Journals Online (AJOL)

2011-06-15

Jun 15, 2011 ... Six cases of surgical acute abdomen in sickle cell disease patients treated in the University ... index of suspicion coupled with repeated clinical examination is needed for early diagnosis and ... Click here to download free Android application for this journal ... and diagnosis, investigations, surgical treatment,.
The acknowledgement of the Schneeberg lung disease as occupational disease in the first decree of occupational diseases from 1925

International Nuclear Information System (INIS)

Schuettmann, W.

1987-01-01

The Schneeberg lung disease is the lung cancer, conditioned by radiation which is caused by the influence of radon and of its subsequent products. It has gained a great importance after World War II as a consequence of the intensified mining of uranium ore. From the history of the disease, lasting some centuries, the period of the twenties and thirties of this century is represented in which on one side the conception of the causal importance of radon has made its way little by little, and on the other side the disease was acknowledged as occupational disease within the first decree of occupational diseases in the former German Reich. Evaluating materials from Saxon archives it is described how the legislative preparations to the acknowledgement of the Schneeberg lung disease as occupational disease and the simultaneous research to the elucidation of nature and cause of the disease have penetrated and influenced each other. (author)
Cuticular antifungals in spiders: density- and condition dependence.

Directory of Open Access Journals (Sweden)

Daniel González-Tokman

Full Text Available Animals living in groups face a high risk of disease contagion. In many arthropod species, cuticular antimicrobials constitute the first protective barrier that prevents infections. Here we report that group-living spiders produce cuticular chemicals which inhibit fungal growth. Given that cuticular antifungals may be costly to produce, we explored whether they can be modulated according to the risk of contagion (i.e. under high densities. For this purpose, we quantified cuticular antifungal activity in the subsocial crab spider Diaea ergandros in both natural nests and experimentally manipulated nests of varying density. We quantified the body-condition of spiders to test whether antifungal activity is condition dependent, as well as the effect of spider density on body-condition. We predicted cuticular antifungal activity to increase and body-condition to decrease with high spider densities, and that antifungal activity would be inversely related to body-condition. Contrary to our predictions, antifungal activity was neither density- nor condition-dependent. However, body-condition decreased with density in natural nests, but increased in experimental nests. We suggest that pathogen pressure is so important in nature that it maintains high levels of cuticular antifungal activity in spiders, impacting negatively on individual energetic condition. Future studies should identify the chemical structure of the isolated antifungal compounds in order to understand the physiological basis of a trade-off between disease prevention and energetic condition caused by group living, and its consequences in the evolution of sociality in spiders.
Cuticular antifungals in spiders: density- and condition dependence.

Science.gov (United States)

González-Tokman, Daniel; Ruch, Jasmin; Pulpitel, Tamara; Ponton, Fleur

2014-01-01

Animals living in groups face a high risk of disease contagion. In many arthropod species, cuticular antimicrobials constitute the first protective barrier that prevents infections. Here we report that group-living spiders produce cuticular chemicals which inhibit fungal growth. Given that cuticular antifungals may be costly to produce, we explored whether they can be modulated according to the risk of contagion (i.e. under high densities). For this purpose, we quantified cuticular antifungal activity in the subsocial crab spider Diaea ergandros in both natural nests and experimentally manipulated nests of varying density. We quantified the body-condition of spiders to test whether antifungal activity is condition dependent, as well as the effect of spider density on body-condition. We predicted cuticular antifungal activity to increase and body-condition to decrease with high spider densities, and that antifungal activity would be inversely related to body-condition. Contrary to our predictions, antifungal activity was neither density- nor condition-dependent. However, body-condition decreased with density in natural nests, but increased in experimental nests. We suggest that pathogen pressure is so important in nature that it maintains high levels of cuticular antifungal activity in spiders, impacting negatively on individual energetic condition. Future studies should identify the chemical structure of the isolated antifungal compounds in order to understand the physiological basis of a trade-off between disease prevention and energetic condition caused by group living, and its consequences in the evolution of sociality in spiders.
Calving body condition score combined with milk test data and rectal tempreture improved the prognostic value of non-invasive markers for infectious diseases in Holestein cows

DEFF Research Database (Denmark)

Mansouryar, M.; Mirzaei-Alamouti, H.; Banadaky, M. Dehghan

2018-01-01

Early lactating dairy cows, are predisposed for calving-related diseases. Early prediction of “at risk” animals increases the likelihood of a successful recovery. In this regard, test-days milk data and body condition score (BCS) at calving have been evaluated as potential indicators of cows at......), BCS at calving and at the first two milk test-days and RT measured daily from day 1 (parturition) to 14 postpartum. Cows were furthermore monitored for subclinical mastitis (SCM), metritis and endometritis in the postpartum period, and diseases diagnosed using standardized definitions. The predicting...... value of variables were evaluated by Receiver Operating Characteristic (ROC) analysis. None of the determined variables provided accuracy individually in prediction of post-partum diseases. Only the mean value of rectal temperature at week 2 (RT2) showed an area under the curve (AUC) higher than 0...
Blount disease

Science.gov (United States)

... Unlike bowlegs , which tend to straighten as the child develops, Blount disease slowly gets worse. It can cause severe bowing of one or both legs. This condition is more common among African American children. It is also associated with obesity ...
Partial response to proton pump inhibitor therapy for GERD: observational study of patient characteristics, burden of disease, and costs in the USA

OpenAIRE

St?lhammar, Nils-Olov; Spiegel, Brennan M; Granstedt L?fman, Helena; Karlsson, Maria; Wahlqvist, Peter; N?sdal, J?rgen; Nelson, M Todd; Despi?gel, Nicolas

2012-01-01

Nils-Olov Stålhammar,1 Brennan M Spiegel,2,3 Helena Granstedt Löfman,1 Maria Karlsson,1 Peter Wahlqvist,1 Jørgen Næsdal,4 M Todd Nelson,5 Nicolas Despiégel61Payer Evidence, AstraZeneca R&D, Mölndal, Sweden; 2Department of Gastroenterology, VA Greater Los Angeles Healthcare System, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 4Medical Department, AstraZeneca R&D, Mölndal, Sweden; 5Late Phase...
Perioperative Management of Neurological Conditions

Directory of Open Access Journals (Sweden)

Manjeet Singh Dhallu

2017-06-01

Full Text Available Perioperative care of the patients with neurological diseases can be challenging. Most important consideration is the management and understanding of pathophysiology of these disorders and evaluation of new neurological changes that occur perioperatively. Perioperative generally refers to 3 phases of surgery: preoperative, intraoperative, and postoperative. We have tried to address few commonly encountered neurological conditions in clinical practice, such as delirium, stroke, epilepsy, myasthenia gravis, and Parkinson disease. In this article, we emphasize on early diagnosis and management strategies of neurological disorders in the perioperative period to minimize morbidity and mortality of patients.
A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration.

Science.gov (United States)

Hara, Satoshi; Kawano, Mitsuhiro; Mizushima, Ichiro; Yamada, Kazunori; Fujita, Kentaro; Harada, Kenichi; Matsumura, Masami; Yamagishi, Masakazu; Sato, Yasuharu; Yamaguchi, Yutaka; Nakanuma, Yasuni; Nagata, Michio

2016-09-01

We describe a 74-year-old Japanese man with systemic fibroinflammatory conditions closely resembling those of immunoglobulin G4-related disease (IgG4-RD). Radiology and histology showed characteristics of IgG4-related tubulointerstitial nephritis, despite normal serum IgG4 value and scanty IgG4-positive plasma cell infiltration in each organ. This case suggests that a condition closely mimicking IgG4-RD may develop without IgG4-positive plasma cells and those exceptional cases should also be taken into account in the differential diagnosis of IgG4-RD.
Genetics Home Reference: X-linked lymphoproliferative disease

Science.gov (United States)

... my area? Other Names for This Condition Duncan disease Epstein-Barr virus-induced lymphoproliferative disease in males familial fatal ... the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma development. ...
Periodontitis and systemic diseases : a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

NARCIS (Netherlands)

Linden, Gerry J; Herzberg, Mark C; van Winkelhoff, Arie

BACKGROUND: There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM: To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary
Sociodemographic disparities in the occurrence of medical conditions among adolescent and young adult Hodgkin lymphoma survivors.

Science.gov (United States)

Keegan, Theresa H M; Li, Qian; Steele, Amy; Alvarez, Elysia M; Brunson, Ann; Flowers, Christopher R; Glaser, Sally L; Wun, Ted

2018-06-01

Hodgkin lymphoma (HL) survivors experience high risks of second cancers and cardiovascular disease, but no studies have considered whether the occurrence of these and other medical conditions differ by sociodemographic factors in adolescent and young adult (AYA) survivors. Data for 5,085 patients aged 15-39 when diagnosed with HL during 1996-2012 and surviving ≥ 2 years were obtained from the California Cancer Registry and linked to hospitalization data. We examined the impact of race/ethnicity, neighborhood socioeconomic status (SES), and health insurance on the occurrence of medical conditions (≥ 2 years after diagnosis) and the impact of medical conditions on survival using multivariable Cox proportional hazards regression. Twenty-six percent of AYAs experienced at least one medical condition and 15% had ≥ 2 medical conditions after treatment for HL. In multivariable analyses, Black HL survivors had a higher likelihood (vs. non-Hispanic Whites) of endocrine [hazard ratio (HR) = 1.37, 95% confidence interval (CI) 1.05-1.78] and circulatory system diseases (HR = 1.58, CI 1.17-2.14); Hispanics had a higher likelihood of endocrine diseases [HR = 1.24 (1.04-1.48)]. AYAs with public or no insurance (vs. private/military) had higher likelihood of circulatory system diseases, respiratory system diseases, chronic kidney disease/renal failure, liver disease, and endocrine diseases. AYAs residing in low SES neighborhoods (vs. high) had higher likelihood of respiratory system and endocrine diseases. AYAs with these medical conditions or second cancers had an over twofold increased risk of death. Strategies to improve health care utilization for surveillance and secondary prevention among AYA HL survivors at increased risk of medical conditions may improve outcomes.
In Vitro Disease Model of Microgravity Conditioning on Human Energy Metabolism

Science.gov (United States)

Snyder, Jessica; Culbertson, C.; Zhang, Ye; Emami, K.; Wu, H.; Sun, Wei

2010-01-01

NASA and its partners are committed to introducing appropriate new technology to enable learning and living safely beyond the Earth for extended periods of time in a sustainable and possibly indefinite manner. In the responsible acquisition of that goal, life sciences is tasked to tune and advance current medical technology to prepare for human health and wellness in the space environment. The space environment affects the condition and function of biological systems from organ level function to shape of individual organelles. The objective of this paper is to study the effect of microgravity on kinetics of drug metabolism. This fundamental characterization is meaningful to (1) scientific understanding of the response of biology to microgravity and (2) clinical dosing requirements and pharmacological thresholds during long term manned space exploration. Metabolism kinetics of the anti-nausea drug promethazine (PMZ) were determined by an in vitro ground model of 3-dimensional aggregates of human hepatocytes conditioned to weightlessness using a rotating wall bioreactor. The authors observed up-regulated PMZ conversion in model microgravity conditions and attribute this to effect to model microgravity conditioning acting on metabolic mechanisms of the cells. Further work is necessary to determine which particular cellular mechanisms are governing the experimental observations, but the authors conclude kinetics of drug metabolism are responsive to gravitational fields and further study of this sensitivity would improve dosing of pharmaceuticals to persons exposed to a microgravity environment.

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