Enzymatic Ligation Creates Discrete Multi-Nanoparticle Building Blocks for Self-Assembly
Energy Technology Data Exchange (ETDEWEB)
Claridge, Shelley A.; Mastroianni, Alexander J.; Au, Yeung B.; Liang, Huiyang W.; Micheel, Christine M.; Frechet, Jean M.J.; Alivisatos, A. Paul
2008-05-27
Enzymatic ligation of discrete nanoparticle?DNA conjugates creates nanoparticle dimer and trimer structures in which the nanoparticles are linked by single-stranded DNA, rather than double-stranded DNA as in previous experiments. Ligation is verified by agarose gel and small-angle X-ray scattering. This capability is utilized in two ways: first to create a new class of multiparticle building blocks for nanoscale self-assembly; second to develop a system which can amplify a population of discrete nanoparticle assemblies.
Energy Technology Data Exchange (ETDEWEB)
Guo, Jun; Zhong, Ruibo; Li, Wanrong; Liu, Yushuang; Bai, Zhijun; Yin, Jun; Liu, Jingran; Gong, Pei [Agricultural Nanocenter, School of Life Science, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Hohhot 010018 (China); Zhao, Xinmin, E-mail: zhao.xinmin@hotmail.com [School of Foreign Language, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Hohhot 010018 (China); Zhang, Feng, E-mail: fengzhang1978@hotmail.com [Agricultural Nanocenter, School of Life Science, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Hohhot 010018 (China)
2015-12-30
Graphical abstract: With the non-uniform coating of amphiphilic polymer, the silver nanoparticles (AgNPs) can form protein coronas which can become discrete protein–nanoparticle conjugates when controlling the protein–nanoparticle molar ratios. The protein's conformational changes upon binding NPs was also studied by both circular dichroism and three-dimensional fluorescence spectroscopy. - Highlights: • The amphiphilic polymer coating can not only transfer hydrophobic NPs into water soluble, but also providing a thick shell responsible for the strong physisorption to proteins without significantly changing their spatial conformations. • NP with discrete proteins can be simply obtained by a simple mixing procedure followed by a gel electrophoresis separation, and the resulting conjugates are robust enough to resist common separation techniques like gel electrophoresis. • In combination with the universal amphiphilic polymer coating strategy and the physisorption mediated protein–NP conjugation, proteins like BSA can be effectively conjugated to different materials such as noble metal, semiconductor and magnetic NPs. • In contrast to chemical coupling methods, the physisorption mediated protein–NP conjugation holds facile, robust and reversible advantages, which may find wide applications in nano-biomedicine field. - Abstract: The nanostructures formed by inorganic nanoparticles together with organic molecules especially biomolecules have attracted increasing attention from both industries and researching fields due to their unique hybrid properties. In this paper, we systemically studied the interactions between amphiphilic polymer coated silver nanoparticles and bovine serum albumins by employing the fluorescence quenching approach in combination with the Stern-Volmer and Hill equations. The binding affinity was determined to 1.30 × 10{sup 7} M{sup −1} and the interaction was spontaneously driven by mainly the van der Waals force and
International Nuclear Information System (INIS)
Yang, Xiaoli; Hofmann, Ralf; Dapp, Robin; Van de Kamp, Thomas; Rolo, Tomy dos Santos; Xiao, Xianghui; Moosmann, Julian; Kashef, Jubin; Stotzka, Rainer
2015-01-01
High-resolution, three-dimensional (3D) imaging of soft tissues requires the solution of two inverse problems: phase retrieval and the reconstruction of the 3D image from a tomographic stack of two-dimensional (2D) projections. The number of projections per stack should be small to accommodate fast tomography of rapid processes and to constrain X-ray radiation dose to optimal levels to either increase the duration o fin vivo time-lapse series at a given goal for spatial resolution and/or the conservation of structure under X-ray irradiation. In pursuing the 3D reconstruction problem in the sense of compressive sampling theory, we propose to reduce the number of projections by applying an advanced algebraic technique subject to the minimisation of the total variation (TV) in the reconstructed slice. This problem is formulated in a Lagrangian multiplier fashion with the parameter value determined by appealing to a discrete L-curve in conjunction with a conjugate gradient method. The usefulness of this reconstruction modality is demonstrated for simulated and in vivo data, the latter acquired in parallel-beam imaging experiments using synchrotron radiation
DEFF Research Database (Denmark)
Sørensen, John Aasted
2011-01-01
The objectives of Discrete Mathematics (IDISM2) are: The introduction of the mathematics needed for analysis, design and verification of discrete systems, including the application within programming languages for computer systems. Having passed the IDISM2 course, the student will be able...... to accomplish the following: -Understand and apply formal representations in discrete mathematics. -Understand and apply formal representations in problems within discrete mathematics. -Understand methods for solving problems in discrete mathematics. -Apply methods for solving problems in discrete mathematics......; construct a finite state machine for a given application. Apply these concepts to new problems. The teaching in Discrete Mathematics is a combination of sessions with lectures and students solving problems, either manually or by using Matlab. Furthermore a selection of projects must be solved and handed...
Modelling conjugation with stochastic differential equations
DEFF Research Database (Denmark)
Philipsen, Kirsten Riber; Christiansen, Lasse Engbo; Hasman, Henrik
2010-01-01
using a likelihood-ratio test and Akaike's information criterion. Experiments indicating conjugation on the agar plates selecting for transconjugants motivates the introduction of an extended model, for which conjugation on the agar plate is described in the measurement equation. This model is compared......Conjugation is an important mechanism involved in the transfer of resistance between bacteria. In this article a stochastic differential equation based model consisting of a continuous time state equation and a discrete time measurement equation is introduced to model growth and conjugation of two...
DEFF Research Database (Denmark)
Busch, Peter Andre; Zinner Henriksen, Helle
2018-01-01
discretion is suggested to reduce this footprint by influencing or replacing their discretionary practices using ICT. What is less researched is whether digital discretion can cause changes in public policy outcomes, and under what conditions such changes can occur. Using the concept of public service values......This study reviews 44 peer-reviewed articles on digital discretion published in the period from 1998 to January 2017. Street-level bureaucrats have traditionally had a wide ability to exercise discretion stirring debate since they can add their personal footprint on public policies. Digital......, we suggest that digital discretion can strengthen ethical and democratic values but weaken professional and relational values. Furthermore, we conclude that contextual factors such as considerations made by policy makers on the macro-level and the degree of professionalization of street...
Directory of Open Access Journals (Sweden)
Simona Mihaiu
2015-10-01
Full Text Available Scientific knowledge of different aspects related to conjugal violence is highly important for people directly involved, such as researchers, practitioners and the entire society. In this respect, globally, specialised studies continue to advance, offer correct definitions, clear descriptions, convincing assessments to certain issues, encouraging thus long-term research, since some specialists have managed to overcome restrictive or ideological methods and explanations. Moreover, in practice, debates reach almost all social, political and legal dimensions regarding appropriate and efficient forms of preventing conjugal violence. Unfortunately, in Romania there are fewer research and prevention approaches of this social problem. In general, attention is directed to domestic violence and conjugal violence is dealt with only implicitly. Considering the given context, the aim of the paper is to outline, by analysing specialised literature, a new research direction and implicitly, social intervention. I specify that this article represents a stage in the ongoing postdoctoral research project, entitled "Conjugal homicide. Aggressors and victims".
DEFF Research Database (Denmark)
Sørensen, John Aasted
2010-01-01
The introduction of the mathematics needed for analysis, design and verification of discrete systems, including applications within programming languages for computer systems. Course sessions and project work. Semester: Spring 2010 Ectent: 5 ects Class size: 18......The introduction of the mathematics needed for analysis, design and verification of discrete systems, including applications within programming languages for computer systems. Course sessions and project work. Semester: Spring 2010 Ectent: 5 ects Class size: 18...
DEFF Research Database (Denmark)
Sørensen, John Aasted
2010-01-01
The introduction of the mathematics needed for analysis, design and verification of discrete systems, including applications within programming languages for computer systems. Course sessions and project work. Semester: Autumn 2010 Ectent: 5 ects Class size: 15......The introduction of the mathematics needed for analysis, design and verification of discrete systems, including applications within programming languages for computer systems. Course sessions and project work. Semester: Autumn 2010 Ectent: 5 ects Class size: 15...
Modelling conjugation with stochastic differential equations.
Philipsen, K R; Christiansen, L E; Hasman, H; Madsen, H
2010-03-07
Conjugation is an important mechanism involved in the transfer of resistance between bacteria. In this article a stochastic differential equation based model consisting of a continuous time state equation and a discrete time measurement equation is introduced to model growth and conjugation of two Enterococcus faecium strains in a rich exhaustible media. The model contains a new expression for a substrate dependent conjugation rate. A maximum likelihood based method is used to estimate the model parameters. Different models including different noise structure for the system and observations are compared using a likelihood-ratio test and Akaike's information criterion. Experiments indicating conjugation on the agar plates selecting for transconjugants motivates the introduction of an extended model, for which conjugation on the agar plate is described in the measurement equation. This model is compared to the model without plate conjugation. The modelling approach described in this article can be applied generally when modelling dynamical systems. 2009 Elsevier Ltd. All rights reserved.
Directory of Open Access Journals (Sweden)
Augusto Hernández Vidal
2011-12-01
Full Text Available In order to strengthen the concept of municipal autonomy, this essay proposes an extensive interpretation of administrative discretion. Discretion is the exercise of free judgment given by law to authorities for performing official acts. This legislative technique seems to be suitable whenever the legislative is intended to legislate over the essential core of municipal autonomy. This way, an eventual abuse of that autonomy could be avoided, for the disproportional restriction of the local faculty to oversee the local issues. This alternative is presented as a tool to provide with dynamism the performing of administrative activities as well, aiming to assimilate public administration new practices.
International Nuclear Information System (INIS)
Lee, T.D.
1985-01-01
This paper reviews the role of time throughout all phases of mechanics: classical mechanics, non-relativistic quantum mechanics, and relativistic quantum theory. As an example of the relativistic quantum field theory, the case of a massless scalar field interacting with an arbitrary external current is discussed. The comparison between the new discrete theory and the usual continuum formalism is presented. An example is given of a two-dimensional random lattice and its duel. The author notes that there is no evidence that the discrete mechanics is more appropriate than the usual continuum mechanics
DEFF Research Database (Denmark)
Sørensen, John Aasted
2011-01-01
The objectives of Discrete Mathematics (IDISM2) are: The introduction of the mathematics needed for analysis, design and verification of discrete systems, including the application within programming languages for computer systems. Having passed the IDISM2 course, the student will be able....... Having completed this the student is able to carry out the following: Expressions and sets: Define a set; define a logic expression; negate a logic expression; combine logic expressions; construct a truth table for a logic expression; apply reduction rules for logic expressions. Apply these concepts...
Caltagirone, Jean-Paul
2014-01-01
This book presents the fundamental principles of mechanics to re-establish the equations of Discrete Mechanics. It introduces physics and thermodynamics associated to the physical modeling. The development and the complementarity of sciences lead to review today the old concepts that were the basis for the development of continuum mechanics. The differential geometry is used to review the conservation laws of mechanics. For instance, this formalism requires a different location of vector and scalar quantities in space. The equations of Discrete Mechanics form a system of equations where the H
International Nuclear Information System (INIS)
Sharpe, Eric
2003-01-01
In this article we explain discrete torsion. Put simply, discrete torsion is the choice of orbifold group action on the B field. We derive the classification H 2 (Γ,U(1)), the twisted sector phases appearing in string loop partition functions, Douglas's description of discrete torsion for D-branes in terms of a projective representation of the orbifold group, and outline how the results of Vafa and Witten fit into this framework. In addition, we observe that additional degrees of freedom (known as shift orbifolds) appear in describing orbifold group actions on B fields, in addition to those classified by H 2 (Γ,U(1)), and explain how these degrees of freedom appear in terms of twisted sector contributions to partition functions and in terms of orbifold actions on D-brane worldvolumes. This paper represents a technically simplified version of prior papers by the author on discrete torsion. We repeat here technically simplified versions of results from those papers, and have included some new material
A discretized algorithm for the solution of a constrained, continuous ...
African Journals Online (AJOL)
A discretized algorithm for the solution of a constrained, continuous quadratic control problem. ... Numerical solution techniques such as Function space algorithm (FSA), Extended conjugate gradient method (ECGM) and Imbedding extended conjugate gradient method (MECGM) are common techniques for solving optimal ...
Shimabukuro, R. H.; Frear, D. S.; Swanson, H. R.; Walsh, W. C.
1971-01-01
The primary factor for atrazine selectivity in corn (Zea mays) is the activity of a soluble enzyme, glutathione S-transferase, which detoxifies atrazine by catalyzing the formation of an atrazine-glutathione conjugate (GS-atrazine). The nonenzymatic, benzoxazinone-catalyzed hydrolysis of atrazine to hydroxyatrazine contributed to the total resistance of corn to atrazine, but the nonenzymatic detoxication pathway does not seem to be essential for resistance. All corn lines investigated, except for susceptible GT112, rapidly detoxified atrazine by glutathione conjugation. Only GT112 had low glutathione S-transferase activity. Hydroxyatrazine was found in significant quantities only when atrazine was introduced initially into the roots. The amount of hydroxyatrazine formed was nearly equal for susceptible GT112 and most of the resistant corn lines investigated. This investigation indicates that some plants protect themselves against toxic organic halide compounds with a mechanism similar to that known to exist in animals. PMID:5543779
Parker, R Gary
1988-01-01
This book treats the fundamental issues and algorithmic strategies emerging as the core of the discipline of discrete optimization in a comprehensive and rigorous fashion. Following an introductory chapter on computational complexity, the basic algorithmic results for the two major models of polynomial algorithms are introduced--models using matroids and linear programming. Further chapters treat the major non-polynomial algorithms: branch-and-bound and cutting planes. The text concludes with a chapter on heuristic algorithms.Several appendixes are included which review the fundamental ideas o
Firth, Jean M
1992-01-01
The analysis of signals and systems using transform methods is a very important aspect of the examination of processes and problems in an increasingly wide range of applications. Whereas the initial impetus in the development of methods appropriate for handling discrete sets of data occurred mainly in an electrical engineering context (for example in the design of digital filters), the same techniques are in use in such disciplines as cardiology, optics, speech analysis and management, as well as in other branches of science and engineering. This text is aimed at a readership whose mathematical background includes some acquaintance with complex numbers, linear differen tial equations, matrix algebra, and series. Specifically, a familiarity with Fourier series (in trigonometric and exponential forms) is assumed, and an exposure to the concept of a continuous integral transform is desirable. Such a background can be expected, for example, on completion of the first year of a science or engineering degree cour...
Discrete Curvatures and Discrete Minimal Surfaces
Sun, Xiang
2012-06-01
This thesis presents an overview of some approaches to compute Gaussian and mean curvature on discrete surfaces and discusses discrete minimal surfaces. The variety of applications of differential geometry in visualization and shape design leads to great interest in studying discrete surfaces. With the rich smooth surface theory in hand, one would hope that this elegant theory can still be applied to the discrete counter part. Such a generalization, however, is not always successful. While discrete surfaces have the advantage of being finite dimensional, thus easier to treat, their geometric properties such as curvatures are not well defined in the classical sense. Furthermore, the powerful calculus tool can hardly be applied. The methods in this thesis, including angular defect formula, cotangent formula, parallel meshes, relative geometry etc. are approaches based on offset meshes or generalized offset meshes. As an important application, we discuss discrete minimal surfaces and discrete Koenigs meshes.
Multigrid and Krylov Subspace Methods for the Discrete Stokes Equations
Elman, Howard C.
1996-01-01
Discretization of the Stokes equations produces a symmetric indefinite system of linear equations. For stable discretizations, a variety of numerical methods have been proposed that have rates of convergence independent of the mesh size used in the discretization. In this paper, we compare the performance of four such methods: variants of the Uzawa, preconditioned conjugate gradient, preconditioned conjugate residual, and multigrid methods, for solving several two-dimensional model problems. The results indicate that where it is applicable, multigrid with smoothing based on incomplete factorization is more efficient than the other methods, but typically by no more than a factor of two. The conjugate residual method has the advantage of being both independent of iteration parameters and widely applicable.
Dielectrophoresis of gold nanoparticles conjugated to DNA origami structures
Directory of Open Access Journals (Sweden)
Anja Henning-Knechtel
2016-07-01
Full Text Available DNA nanostructures are promising construction materials to bridge the gap between self-assembly of functional molecules and conventional top-down fabrication methods in nanotechnology. Their positioning onto specific locations of a microstructured substrate is an important task towards this aim. Here we study manipulation and positioning of pristine and of gold nanoparticle-conjugated tubular DNA origami structures using ac dielectrophoresis. The dielectrophoretic behavior was investigated employing fluorescence microscopy. For the pristine origami, a significant dielectrophoretic response was found to take place in the megahertz range, whereas, due to the higher polarizability of the metallic nanoparticles, the nanoparticle/DNA hybrid structures required a lower electrical field strength and frequency for a comparable trapping at the edges of the electrode structure. The nanoparticle conjugation additionally resulted in a remarkable alteration of the DNA structure arrangement. The growth of linear, chain-like structures in between electrodes at applied frequencies in the megahertz range was observed. The long-range chain formation is caused by a local, gold nanoparticle-induced field concentration along the DNA nanostructures, which in turn, creates dielectrophoretic forces that enable the observed self-alignment of the hybrid structures.
Indian Academy of Sciences (India)
Segmented conjugated polymers, wherein the conjugation is randomly truncated by varying lengths of non-conjugated segments, form an interesting class of polymers as they not only represent systems of varying stiffness, but also ones where the backbone can be construed as being made up of chromophores of varying ...
Groupoids, Discrete Mechanics, and Discrete Variation
International Nuclear Information System (INIS)
Guo Jiafeng; Jia Xiaoyu; Wu Ke; Zhao Weizhong
2008-01-01
After introducing some of the basic definitions and results from the theory of groupoid and Lie algebroid, we investigate the discrete Lagrangian mechanics from the viewpoint of groupoid theory and give the connection between groupoids variation and the methods of the first and second discrete variational principles
Directory of Open Access Journals (Sweden)
Yong Huang
Full Text Available Porcine circovirus type 2 (PCV2 has emerged as one of the most important pathogens affecting swine production globally. Preclinical identification of PCV2 is very important for effective prophylaxis of PCV2-associated diseases. In this study, we developed an ultrasensitive nanoparticle DNA probe-based PCR assay (UNDP-PCR for PCV2 detection. Magnetic microparticles coated with PCV2 specific DNA probes were used to enrich PCV2 DNA from samples, then gold nanoparticles coated with PCV2 specific oligonucleotides were added to form a sandwich nucleic acid-complex. After the complex was formed, the oligonucleotides were released and characterized by PCR. This assay exhibited about 500-fold more sensitive than conventional PCR, with a detection limit of 2 copies of purified PCV2 genomic DNA and 10 viral copies of PCV2 in serum. The assay has a wide detection range for all of PCV2 genotypes with reliable reproducibility. No cross-reactivity was observed from the samples of other related viruses including porcine circovirus type 1, porcine parvovirus, porcine pseudorabies virus, porcine reproductive and respiratory syndrome virus and classical swine fever virus. The positive detection rate of PCV2 specific UNDP-PCR in 40 preclinical field samples was 27.5%, which appeared greater than that by conventional and real-time PCR and appeared application potency in evaluation of the viral loads levels of preclinical infection samples. The UNDP-PCR assay reported here can reliably rule out false negative results from antibody-based assays, provide a nucleic acid extraction free, specific, ultrasensitive, economic and rapid diagnosis method for preclinical PCV2 infection in field, which may help prevent large-scale outbreaks.
Properties of the Simpson discrete fourier transform | Singh ...
African Journals Online (AJOL)
The Simpson discrete Fourier transform (SDFT) and its inverse are transformations relating the time and frequency domains. In this paper we state and prove the important properties of shift, circular convolution, conjugation, time reversal and Plancherel's theorem. In addition, we provide an alternative representation of the ...
Discrete Symmetries in Particle Physics and their Violation
Indian Academy of Sciences (India)
Indian Institute of Science in the field of elementary particle physics. This two-part article considers certain fundamen- tal symmetries of nature, namely the discrete symmetries of parity (P), charge conjugation (C) and time reversal (T), and their possible viola- tion. Recent experimental results are discussed in some depth.
Deflation in preconditioned conjugate gradient methods for Finite Element Problems
Vermolen, F.J.; Vuik, C.; Segal, A.
2002-01-01
We investigate the influence of the value of deflation vectors at interfaces on the rate of convergence of preconditioned conjugate gradient methods applied to a Finite Element discretization for an elliptic equation. Our set-up is a Poisson problem in two dimensions with continuous or discontinuous
Deep Discrete Supervised Hashing
Jiang, Qing-Yuan; Cui, Xue; Li, Wu-Jun
2017-01-01
Hashing has been widely used for large-scale search due to its low storage cost and fast query speed. By using supervised information, supervised hashing can significantly outperform unsupervised hashing. Recently, discrete supervised hashing and deep hashing are two representative progresses in supervised hashing. On one hand, hashing is essentially a discrete optimization problem. Hence, utilizing supervised information to directly guide discrete (binary) coding procedure can avoid sub-opti...
Okuyama, Yoshifumi
2014-01-01
Discrete Control Systems establishes a basis for the analysis and design of discretized/quantized control systemsfor continuous physical systems. Beginning with the necessary mathematical foundations and system-model descriptions, the text moves on to derive a robust stability condition. To keep a practical perspective on the uncertain physical systems considered, most of the methods treated are carried out in the frequency domain. As part of the design procedure, modified Nyquist–Hall and Nichols diagrams are presented and discretized proportional–integral–derivative control schemes are reconsidered. Schemes for model-reference feedback and discrete-type observers are proposed. Although single-loop feedback systems form the core of the text, some consideration is given to multiple loops and nonlinearities. The robust control performance and stability of interval systems (with multiple uncertainties) are outlined. Finally, the monograph describes the relationship between feedback-control and discrete ev...
Qualidade conjugal: mapeando conceitos
Directory of Open Access Journals (Sweden)
Clarisse Mosmann
2006-12-01
Full Text Available Apesar da ampla utilização do conceito de qualidade conjugal, identifica-se falta de clareza conceitual acerca das variáveis que o compõem. Esse artigo apresenta revisão da literatura na área com o objetivo de mapear o conceito de qualidade conjugal. Foram analisadas sete principais teorias sobre o tema: Troca Social, Comportamental, Apego, Teoria da Crise, Interacionismo Simbólico. Pelos postulados propostos nas diferentes teorias, podem-se identificar três grupos de variáveis fundamentais na definição da qualidade conjugal: recursos pessoais dos cônjuges, contexto de inserção do casal e processos adaptativos. Neste sentido, a qualidade conjugal é resultado do processo dinâmico e interativo do casal, razão deste caráter multidimensional.
Conjugated Polymer Solar Cells
National Research Council Canada - National Science Library
Paraschuk, Dmitry Y
2006-01-01
This report results from a contract tasking Moscow State University as follows: Conjugated polymers are promising materials for many photonics applications, in particular, for photovoltaic and solar cell devices...
Polymers for Protein Conjugation
Directory of Open Access Journals (Sweden)
Gianfranco Pasut
2014-01-01
Full Text Available Polyethylene glycol (PEG at the moment is considered the leading polymer for protein conjugation in view of its unique properties, as well as to its low toxicity in humans, qualities which have been confirmed by its extensive use in clinical practice. Other polymers that are safe, biodegradable and custom-designed have, nevertheless, also been investigated as potential candidates for protein conjugation. This review will focus on natural polymers and synthetic linear polymers that have been used for protein delivery and the results associated with their use. Genetic fusion approaches for the preparation of protein-polypeptide conjugates will be also reviewed and compared with the best known chemical conjugation ones.
International Nuclear Information System (INIS)
Williams, Ruth M
2006-01-01
A review is given of a number of approaches to discrete quantum gravity, with a restriction to those likely to be relevant in four dimensions. This paper is dedicated to Rafael Sorkin on the occasion of his sixtieth birthday
Finite Discrete Gabor Analysis
DEFF Research Database (Denmark)
Søndergaard, Peter Lempel
2007-01-01
on the real line to be well approximated by finite and discrete Gabor frames. This method of approximation is especially attractive because efficient numerical methods exists for doing computations with finite, discrete Gabor systems. This thesis presents new algorithms for the efficient computation of finite......, discrete Gabor coefficients. Reconstruction of a signal from its Gabor coefficients is done by the use of a so-called dual window. This thesis presents a number of iterative algorithms to compute dual and self-dual windows. The Linear Time Frequency Toolbox is a Matlab/Octave/C toolbox for doing basic...... discrete time/frequency and Gabor analysis. It is intended to be both an educational and a computational tool. The toolbox was developed as part of this Ph.D. project to provide a solid foundation for the field of computational Gabor analysis....
Goodrich, Christopher
2015-01-01
This text provides the first comprehensive treatment of the discrete fractional calculus. Experienced researchers will find the text useful as a reference for discrete fractional calculus and topics of current interest. Students who are interested in learning about discrete fractional calculus will find this text to provide a useful starting point. Several exercises are offered at the end of each chapter and select answers have been provided at the end of the book. The presentation of the content is designed to give ample flexibility for potential use in a myriad of courses and for independent study. The novel approach taken by the authors includes a simultaneous treatment of the fractional- and integer-order difference calculus (on a variety of time scales, including both the usual forward and backwards difference operators). The reader will acquire a solid foundation in the classical topics of the discrete calculus while being introduced to exciting recent developments, bringing them to the frontiers of the...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 1. Discrete Event Simulation. Matthew Jacob ... Keywords. Simulation; modelling; computer programming. Author Affiliations. Matthew Jacob1. Department of Computer Science and Automation, Indian Institute of Science, Bangalore 560 012.
The Discrete Wavelet Transform
1991-06-01
B-1 ,.iii FIGURES 1.1 A wavelet filter bank structure ..................................... 2 2.1 Diagram illustrating the dialation and...abstract decompositions of discrete time series. Their wide sweeping significance, however, lies in their interpretation as wavelet transforms. In a general...parameter transform wn in the scale- time plane. Following terminology to be intro- duced, wi is the (decimated) discrete wavelet transform. become the
Indian Academy of Sciences (India)
\\;j t E ~. On the other hand, if the signal is defined only at discrete instants of time and not elsewhere i.e., t takes on only the discrete values t = kT for some range of integer values of k, the signal ... is applied to an electronic switch that is closed for a mo- ment every ... ture (T = 1 hour), banking transactions (T = ~ year), census.
Discrete computational structures
Korfhage, Robert R
1974-01-01
Discrete Computational Structures describes discrete mathematical concepts that are important to computing, covering necessary mathematical fundamentals, computer representation of sets, graph theory, storage minimization, and bandwidth. The book also explains conceptual framework (Gorn trees, searching, subroutines) and directed graphs (flowcharts, critical paths, information network). The text discusses algebra particularly as it applies to concentrates on semigroups, groups, lattices, propositional calculus, including a new tabular method of Boolean function minimization. The text emphasize
Discrete systems and integrability
Hietarinta, J; Nijhoff, F W
2016-01-01
This first introductory text to discrete integrable systems introduces key notions of integrability from the vantage point of discrete systems, also making connections with the continuous theory where relevant. While treating the material at an elementary level, the book also highlights many recent developments. Topics include: Darboux and Bäcklund transformations; difference equations and special functions; multidimensional consistency of integrable lattice equations; associated linear problems (Lax pairs); connections with Padé approximants and convergence algorithms; singularities and geometry; Hirota's bilinear formalism for lattices; intriguing properties of discrete Painlevé equations; and the novel theory of Lagrangian multiforms. The book builds the material in an organic way, emphasizing interconnections between the various approaches, while the exposition is mostly done through explicit computations on key examples. Written by respected experts in the field, the numerous exercises and the thoroug...
Directory of Open Access Journals (Sweden)
Prateek Sharma
2015-04-01
Full Text Available Abstract Simulation can be regarded as the emulation of the behavior of a real-world system over an interval of time. The process of simulation relies upon the generation of the history of a system and then analyzing that history to predict the outcome and improve the working of real systems. Simulations can be of various kinds but the topic of interest here is one of the most important kind of simulation which is Discrete-Event Simulation which models the system as a discrete sequence of events in time. So this paper aims at introducing about Discrete-Event Simulation and analyzing how it is beneficial to the real world systems.
Introductory discrete mathematics
Balakrishnan, V K
2010-01-01
This concise text offers an introduction to discrete mathematics for undergraduate students in computer science and mathematics. Mathematics educators consider it vital that their students be exposed to a course in discrete methods that introduces them to combinatorial mathematics and to algebraic and logical structures focusing on the interplay between computer science and mathematics. The present volume emphasizes combinatorics, graph theory with applications to some stand network optimization problems, and algorithms to solve these problems.Chapters 0-3 cover fundamental operations involv
Hsiao, Shih-Chia; Francis, Matthew B.; Bertozzi, Carolyn; Mathies, Richard; Chandra, Ravi; Douglas, Erik; Twite, Amy; Toriello, Nicholas; Onoe, Hiroaki
2016-05-03
The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
Photoluminescence in conjugated polymers
International Nuclear Information System (INIS)
Furst, J.E.; Laugesen, R.; Dastoor, P.; McNeill, C.
2002-01-01
Full text: Conjugated polymers combine the electronic and optical properties of semiconductors with the processability of polymers. They contain a sequence of alternate single and double carbon bonds so that the overlap of unhybridised p z orbitals creates a delocalised ρ system which gives semiconducting properties with p-bonding (valence) and p* -antibonding (conduction) bands. Photoluminesence (PL) in conjugated polymers results from the radiative decay of singlet excitons confined to a single chain. The present work is the first in a series of studies in our laboratory that will characterize the optical properties of conjugated polymers. The experiment involves the illumination of thin films of conjugated polymer with UV light (I=360 nm) and observing the subsequent fluorescence using a custom-built, fluorescence spectrometer. Photoluminesence spectra provide basic information about the structure of the polymer film. A typical spectrum is shown in the accompanying figure. The position of the first peak is related to the polymer chain length and resolved multiple vibronic peaks are an indication of film structure and morphology. We will also present results related to the optical degradation of these materials when exposed to air and UV light
International Nuclear Information System (INIS)
Slatkine, M.; Bigio, I.J.; Fisher, R.A.; Maloney, M.L.; Busse, J.R.; Tercovich, R.G.; Feldman, B.J.
1981-01-01
Diffraction-limited phase conjugate reflection of an injection-locked high-power (approx. 1 MW) ultraviolet excimer laser beam has been demonstrated via stimulated Brillouin scattering. Reflectivities higher than 70% were attained. Limitations as well as coherence and power requirements for image retention are discussed
Bahr, Stephen L.; Rollins, Boyd C.
1971-01-01
It was hypothesized that the more equalitarian the conjugal power structure in a noncrisis situation, the more likely the relative marital power will change during a crisis. This was tested using an observational experimental method, and the hypothesis was supported. (Author/CG)
DEFF Research Database (Denmark)
Hansen, Paul Robert
2015-01-01
To produce antibodies against synthetic peptides it is necessary to couple them to a protein carrier. This chapter provides a nonspecialist overview of peptide-carrier conjugation. Furthermore, a protocol for coupling cysteine-containing peptides to bovine serum albumin is outlined....
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 2. Discrete-Time Systems - Why do We Celebrate Birthdays Once a Year? A Ramakalyan P Kavitha S Harini Vijayalakshmi. General Article Volume 5 Issue 2 February 2000 pp 39-49 ...
Wachiralurpan, Sirirat; Sriyapai, Thayat; Areekit, Supatra; Sriyapai, Pichapak; Augkarawaritsawong, Suphitcha; Santiwatanakul, Somchai; Chansiri, Kosum
2018-04-01
ABSTRACT Listeria monocytogenes is a major foodborne pathogen of global health concern. Herein, the rapid diagnosis of L. monocytogenes has been achieved using loop-mediated isothermal amplification (LAMP) based on the phosphatidylcholine-phospholipase C gene (plcB). Colorimetric detection was then performed through the formation of DNA concatemers and a gold nanoparticle/DNA probe complex (GNP/DNA probe). The overall detection process was accomplished within approximately 1 h with no need for complicated equipment. The limits of detection for L. monocytogenes in the forms of purified genomic DNA and pure culture were 800 fg and 2.82 CFU mL-1, respectively. No cross reactions were observed from closely related bacteria species. The LAMP-GNP/DNA probe assay was applied to the detection of 200 raw chicken meat samples and compared to routine standard methods. The data revealed that the specificity, sensitivity and accuracy were 100%, 90.20% and 97.50%, respectively. The present assay was 100% in conformity with LAMP-agarose gel electrophoresis assay. Five samples that were negative by both assays appeared to have the pathogen at below the level of detection. The assay can be applied as a rapid direct screening method for L. monocytogenes.
High Mobility Conjugated Polymers
2007-10-20
blends with poly(3- hexylthiophene) (PHT) could be readily fabricated as uniform nanofibers by co- electrospinning their solutions with another solution...We have demonstrated that nanofibers of conjugated 10 - polymers and their blends could be conveniently fabricated by electrospinning . Furthermore, we...luminance o - - characteristics of an ITO/ PEDOT /TAPC k D r a Vol gt, V, (V) /BPQ-PPO/LiF/A! device are shown in Fig. 30. (A) Current density-voltage
Discrete mathematics with applications
Koshy, Thomas
2003-01-01
This approachable text studies discrete objects and the relationsips that bind them. It helps students understand and apply the power of discrete math to digital computer systems and other modern applications. It provides excellent preparation for courses in linear algebra, number theory, and modern/abstract algebra and for computer science courses in data structures, algorithms, programming languages, compilers, databases, and computation.* Covers all recommended topics in a self-contained, comprehensive, and understandable format for students and new professionals * Emphasizes problem-solving techniques, pattern recognition, conjecturing, induction, applications of varying nature, proof techniques, algorithm development and correctness, and numeric computations* Weaves numerous applications into the text* Helps students learn by doing with a wealth of examples and exercises: - 560 examples worked out in detail - More than 3,700 exercises - More than 150 computer assignments - More than 600 writing projects*...
2002-01-01
Discrete geometry investigates combinatorial properties of configurations of geometric objects. To a working mathematician or computer scientist, it offers sophisticated results and techniques of great diversity and it is a foundation for fields such as computational geometry or combinatorial optimization. This book is primarily a textbook introduction to various areas of discrete geometry. In each area, it explains several key results and methods, in an accessible and concrete manner. It also contains more advanced material in separate sections and thus it can serve as a collection of surveys in several narrower subfields. The main topics include: basics on convex sets, convex polytopes, and hyperplane arrangements; combinatorial complexity of geometric configurations; intersection patterns and transversals of convex sets; geometric Ramsey-type results; polyhedral combinatorics and high-dimensional convexity; and lastly, embeddings of finite metric spaces into normed spaces. Jiri Matousek is Professor of Com...
Salinelli, Ernesto
2014-01-01
This book provides an introduction to the analysis of discrete dynamical systems. The content is presented by an unitary approach that blends the perspective of mathematical modeling together with the ones of several discipline as Mathematical Analysis, Linear Algebra, Numerical Analysis, Systems Theory and Probability. After a preliminary discussion of several models, the main tools for the study of linear and non-linear scalar dynamical systems are presented, paying particular attention to the stability analysis. Linear difference equations are studied in detail and an elementary introduction of Z and Discrete Fourier Transform is presented. A whole chapter is devoted to the study of bifurcations and chaotic dynamics. One-step vector-valued dynamical systems are the subject of three chapters, where the reader can find the applications to positive systems, Markov chains, networks and search engines. The book is addressed mainly to students in Mathematics, Engineering, Physics, Chemistry, Biology and Economic...
Time Discretization Techniques
Gottlieb, S.
2016-10-12
The time discretization of hyperbolic partial differential equations is typically the evolution of a system of ordinary differential equations obtained by spatial discretization of the original problem. Methods for this time evolution include multistep, multistage, or multiderivative methods, as well as a combination of these approaches. The time step constraint is mainly a result of the absolute stability requirement, as well as additional conditions that mimic physical properties of the solution, such as positivity or total variation stability. These conditions may be required for stability when the solution develops shocks or sharp gradients. This chapter contains a review of some of the methods historically used for the evolution of hyperbolic PDEs, as well as cutting edge methods that are now commonly used.
Indian Academy of Sciences (India)
the birth rate, d is the death rate and u(k) is the number of net immigrants entering the country in year k. We leave it to the reader to model the vacillating mathe- matician problem [3] as a discrete-time system. General Forms of Difference Equations. An nth order difference equation may be written, typically, either as y(k + n) + ...
International Nuclear Information System (INIS)
Jalnapurkar, Sameer M; Leok, Melvin; Marsden, Jerrold E; West, Matthew
2006-01-01
This paper develops the theory of Abelian Routh reduction for discrete mechanical systems and applies it to the variational integration of mechanical systems with Abelian symmetry. The reduction of variational Runge-Kutta discretizations is considered, as well as the extent to which symmetry reduction and discretization commute. These reduced methods allow the direct simulation of dynamical features such as relative equilibria and relative periodic orbits that can be obscured or difficult to identify in the unreduced dynamics. The methods are demonstrated for the dynamics of an Earth orbiting satellite with a non-spherical J 2 correction, as well as the double spherical pendulum. The J 2 problem is interesting because in the unreduced picture, geometric phases inherent in the model and those due to numerical discretization can be hard to distinguish, but this issue does not appear in the reduced algorithm, where one can directly observe interesting dynamical structures in the reduced phase space (the cotangent bundle of shape space), in which the geometric phases have been removed. The main feature of the double spherical pendulum example is that it has a non-trivial magnetic term in its reduced symplectic form. Our method is still efficient as it can directly handle the essential non-canonical nature of the symplectic structure. In contrast, a traditional symplectic method for canonical systems could require repeated coordinate changes if one is evoking Darboux' theorem to transform the symplectic structure into canonical form, thereby incurring additional computational cost. Our method allows one to design reduced symplectic integrators in a natural way, despite the non-canonical nature of the symplectic structure
Discrete variational Hamiltonian mechanics
International Nuclear Information System (INIS)
Lall, S; West, M
2006-01-01
The main contribution of this paper is to present a canonical choice of a Hamiltonian theory corresponding to the theory of discrete Lagrangian mechanics. We make use of Lagrange duality and follow a path parallel to that used for construction of the Pontryagin principle in optimal control theory. We use duality results regarding sensitivity and separability to show the relationship between generating functions and symplectic integrators. We also discuss connections to optimal control theory and numerical algorithms
Czech Academy of Sciences Publication Activity Database
Mesiar, Radko; Li, J.; Pap, E.
2013-01-01
Roč. 54, č. 3 (2013), s. 357-364 ISSN 0888-613X R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : concave integral * pseudo-addition * pseudo- multiplication Subject RIV: BA - General Mathematics Impact factor: 1.977, year: 2013 http://library.utia.cas.cz/separaty/2013/E/mesiar-discrete pseudo-integrals. pdf
Hamiltonian Mechanics on Discrete Manifolds
Talasila, V.; Clemente Gallardo, J.; Schaft, A.J. van der
2004-01-01
The mathematical/geometric structure of discrete models of systems, whether these models are obtained after discretization of a smooth system or as a direct result of modeling at the discrete level, have not been studied much. Mostly one is concerned regarding the nature of the solutions, but not
Brauer, Fred; Feng, Zhilan; Castillo-Chavez, Carlos
2010-01-01
The mathematical theory of single outbreak epidemic models really began with the work of Kermack and Mackendrick about decades ago. This gave a simple answer to the long-standing question of why epidemics woould appear suddenly and then disappear just as suddenly without having infected an entire population. Therefore it seemed natural to expect that theoreticians would immediately proceed to expand this mathematical framework both because the need to handle recurrent single infectious disease outbreaks has always been a priority for public health officials and because theoreticians often try to push the limits of exiting theories. However, the expansion of the theory via the inclusion of refined epidemiological classifications or through the incorporation of categories that are essential for the evaluation of intervention strategies, in the context of ongoing epidemic outbreaks, did not materialize. It was the global threat posed by SARS in that caused theoreticians to expand the Kermack-McKendrick single-outbreak framework. Most recently, efforts to connect theoretical work to data have exploded as attempts to deal with the threat of emergent and re-emergent diseases including the most recent H1N1 influenza pandemic, have marched to the forefront of our global priorities. Since data are collected and/or reported over discrete units of time, developing single outbreak models that fit collected data naturally is relevant. In this note, we introduce a discrete-epidemic framework and highlight, through our analyses, the similarities between single-outbreak comparable classical continuous-time epidemic models and the discrete-time models introduced in this note. The emphasis is on comparisons driven by expressions for the final epidemic size.
Wuensche, Andrew
DDLab is interactive graphics software for creating, visualizing, and analyzing many aspects of Cellular Automata, Random Boolean Networks, and Discrete Dynamical Networks in general and studying their behavior, both from the time-series perspective — space-time patterns, and from the state-space perspective — attractor basins. DDLab is relevant to research, applications, and education in the fields of complexity, self-organization, emergent phenomena, chaos, collision-based computing, neural networks, content addressable memory, genetic regulatory networks, dynamical encryption, generative art and music, and the study of the abstract mathematical/physical/dynamical phenomena in their own right.
Discrete mechanics Based on Finite Element Methods
Chen, Jing-bo; Guo, Han-Ying; Wu, Ke
2002-01-01
Discrete Mechanics based on finite element methods is presented in this paper. We also explore the relationship between this discrete mechanics and Veselov discrete mechanics. High order discretizations are constructed in terms of high order interpolations.
Sun, Wenchao; Fletcher, David; van Heeckeren, Rolf Christiaan; Davis, Pamela B.
2014-01-01
DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we established a strategy to efficiently attach peptide ligands to DNA NPs. The non-covalent biotin–streptavidin (SA) interaction was used for ligand conjugation to overcome problems associated with covalent conjugation methods. A fusion protein of SA with the HIV-1 TAT peptide was cloned, expressed, purified and attached to biotinylated DNA NPs. A modified SA system with tetrameric structure but monovalent biotin binding capacity was adopted and shown to reduce the aggregation of biotinylated DNA NPs compared to neutravidin. Compared to unmodified DNA NPs, TAT modified DNA NPs significantly enhanced in vitro gene transfer, particularly at low DNA concentrations. Studies of cellular uptake and cellular distribution of the DNA NPs indicated that attaching TAT enhanced binding of DNA NPs to cell surface but not internalization at high DNA concentrations. In vivo studies showed that TAT modified DNA NPs mediated equal level of gene transfer to the mouse airways via the luminal route compared to unmodified DNA NPs. PMID:22845840
International Nuclear Information System (INIS)
Souza, Manoelito M. de
1997-01-01
We discuss the physical meaning and the geometric interpretation of implementation in classical field theories. The origin of infinities and other inconsistencies in field theories is traced to fields defined with support on the light cone; a finite and consistent field theory requires a light-cone generator as the field support. Then, we introduce a classical field theory with support on the light cone generators. It results on a description of discrete (point-like) interactions in terms of localized particle-like fields. We find the propagators of these particle-like fields and discuss their physical meaning, properties and consequences. They are conformally invariant, singularity-free, and describing a manifestly covariant (1 + 1)-dimensional dynamics in a (3 = 1) spacetime. Remarkably this conformal symmetry remains even for the propagation of a massive field in four spacetime dimensions. We apply this formalism to Classical electrodynamics and to the General Relativity Theory. The standard formalism with its distributed fields is retrieved in terms of spacetime average of the discrete field. Singularities are the by-products of the averaging process. This new formalism enlighten the meaning and the problem of field theory, and may allow a softer transition to a quantum theory. (author)
Discretization of time series data.
Dimitrova, Elena S; Licona, M Paola Vera; McGee, John; Laubenbacher, Reinhard
2010-06-01
An increasing number of algorithms for biochemical network inference from experimental data require discrete data as input. For example, dynamic Bayesian network methods and methods that use the framework of finite dynamical systems, such as Boolean networks, all take discrete input. Experimental data, however, are typically continuous and represented by computer floating point numbers. The translation from continuous to discrete data is crucial in preserving the variable dependencies and thus has a significant impact on the performance of the network inference algorithms. We compare the performance of two such algorithms that use discrete data using several different discretization algorithms. One of the inference methods uses a dynamic Bayesian network framework, the other-a time-and state-discrete dynamical system framework. The discretization algorithms are quantile, interval discretization, and a new algorithm introduced in this article, SSD. SSD is especially designed for short time series data and is capable of determining the optimal number of discretization states. The experiments show that both inference methods perform better with SSD than with the other methods. In addition, SSD is demonstrated to preserve the dynamic features of the time series, as well as to be robust to noise in the experimental data. A C++ implementation of SSD is available from the authors at http://polymath.vbi.vt.edu/discretization .
Discrete Exterior Calculus Discretization of Incompressible Navier-Stokes Equations
Mohamed, Mamdouh S.
2017-05-23
A conservative discretization of incompressible Navier-Stokes equations over surface simplicial meshes is developed using discrete exterior calculus (DEC). Numerical experiments for flows over surfaces reveal a second order accuracy for the developed scheme when using structured-triangular meshes, and first order accuracy otherwise. The mimetic character of many of the DEC operators provides exact conservation of both mass and vorticity, in addition to superior kinetic energy conservation. The employment of barycentric Hodge star allows the discretization to admit arbitrary simplicial meshes. The discretization scheme is presented along with various numerical test cases demonstrating its main characteristics.
Poisson hierarchy of discrete strings
Energy Technology Data Exchange (ETDEWEB)
Ioannidou, Theodora, E-mail: ti3@auth.gr [Faculty of Civil Engineering, School of Engineering, Aristotle University of Thessaloniki, 54249, Thessaloniki (Greece); Niemi, Antti J., E-mail: Antti.Niemi@physics.uu.se [Department of Physics and Astronomy, Uppsala University, P.O. Box 803, S-75108, Uppsala (Sweden); Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, Fédération Denis Poisson, Université de Tours, Parc de Grandmont, F37200, Tours (France); Department of Physics, Beijing Institute of Technology, Haidian District, Beijing 100081 (China)
2016-01-28
The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.
Poisson hierarchy of discrete strings
International Nuclear Information System (INIS)
Ioannidou, Theodora; Niemi, Antti J.
2016-01-01
The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.
Advances in discrete differential geometry
2016-01-01
This is one of the first books on a newly emerging field of discrete differential geometry and an excellent way to access this exciting area. It surveys the fascinating connections between discrete models in differential geometry and complex analysis, integrable systems and applications in computer graphics. The authors take a closer look at discrete models in differential geometry and dynamical systems. Their curves are polygonal, surfaces are made from triangles and quadrilaterals, and time is discrete. Nevertheless, the difference between the corresponding smooth curves, surfaces and classical dynamical systems with continuous time can hardly be seen. This is the paradigm of structure-preserving discretizations. Current advances in this field are stimulated to a large extent by its relevance for computer graphics and mathematical physics. This book is written by specialists working together on a common research project. It is about differential geometry and dynamical systems, smooth and discrete theories, ...
Dark discrete gauge symmetries
International Nuclear Information System (INIS)
Batell, Brian
2011-01-01
We investigate scenarios in which dark matter is stabilized by an Abelian Z N discrete gauge symmetry. Models are surveyed according to symmetries and matter content. Multicomponent dark matter arises when N is not prime and Z N contains one or more subgroups. The dark sector interacts with the visible sector through the renormalizable kinetic mixing and Higgs portal operators, and we highlight the basic phenomenology in these scenarios. In particular, multiple species of dark matter can lead to an unconventional nuclear recoil spectrum in direct detection experiments, while the presence of new light states in the dark sector can dramatically affect the decays of the Higgs at the Tevatron and LHC, thus providing a window into the gauge origin of the stability of dark matter.
Immigration and Prosecutorial Discretion.
Apollonio, Dorie; Lochner, Todd; Heddens, Myriah
Immigration has become an increasingly salient national issue in the US, and the Department of Justice recently increased federal efforts to prosecute immigration offenses. This shift, however, relies on the cooperation of US attorneys and their assistants. Traditionally federal prosecutors have enjoyed enormous discretion and have been responsive to local concerns. To consider how the centralized goal of immigration enforcement may have influenced federal prosecutors in regional offices, we review their prosecution of immigration offenses in California using over a decade's worth of data. Our findings suggest that although centralizing forces influence immigration prosecutions, individual US attorneys' offices retain distinct characteristics. Local factors influence federal prosecutors' behavior in different ways depending on the office. Contrary to expectations, unemployment rates did not affect prosecutors' willingness to pursue immigration offenses, nor did local popular opinion about illegal immigration.
Discrete Minimal Surface Algebras
Directory of Open Access Journals (Sweden)
Joakim Arnlind
2010-05-01
Full Text Available We consider discrete minimal surface algebras (DMSA as generalized noncommutative analogues of minimal surfaces in higher dimensional spheres. These algebras appear naturally in membrane theory, where sequences of their representations are used as a regularization. After showing that the defining relations of the algebra are consistent, and that one can compute a basis of the enveloping algebra, we give several explicit examples of DMSAs in terms of subsets of sl_n (any semi-simple Lie algebra providing a trivial example by itself. A special class of DMSAs are Yang-Mills algebras. The representation graph is introduced to study representations of DMSAs of dimension d ≤ 4, and properties of representations are related to properties of graphs. The representation graph of a tensor product is (generically the Cartesian product of the corresponding graphs. We provide explicit examples of irreducible representations and, for coinciding eigenvalues, classify all the unitary representations of the corresponding algebras.
Discrete Pearson distributions
Energy Technology Data Exchange (ETDEWEB)
Bowman, K.O. [Oak Ridge National Lab., TN (United States); Shenton, L.R. [Georgia Univ., Athens, GA (United States); Kastenbaum, M.A. [Kastenbaum (M.A.), Basye, VA (United States)
1991-11-01
These distributions are generated by a first order recursive scheme which equates the ratio of successive probabilities to the ratio of two corresponding quadratics. The use of a linearized form of this model will produce equations in the unknowns matched by an appropriate set of moments (assumed to exist). Given the moments we may find valid solutions. These are two cases; (1) distributions defined on the non-negative integers (finite or infinite) and (2) distributions defined on negative integers as well. For (1), given the first four moments, it is possible to set this up as equations of finite or infinite degree in the probability of a zero occurrence, the sth component being a product of s ratios of linear forms in this probability in general. For (2) the equation for the zero probability is purely linear but may involve slowly converging series; here a particular case is the discrete normal. Regions of validity are being studied. 11 refs.
Principles of discrete time mechanics
Jaroszkiewicz, George
2014-01-01
Could time be discrete on some unimaginably small scale? Exploring the idea in depth, this unique introduction to discrete time mechanics systematically builds the theory up from scratch, beginning with the historical, physical and mathematical background to the chronon hypothesis. Covering classical and quantum discrete time mechanics, this book presents all the tools needed to formulate and develop applications of discrete time mechanics in a number of areas, including spreadsheet mechanics, classical and quantum register mechanics, and classical and quantum mechanics and field theories. A consistent emphasis on contextuality and the observer-system relationship is maintained throughout.
Conjugative plasmids: Vessels of the communal gene pool
DEFF Research Database (Denmark)
Norman, Anders; Hansen, Lars H.; Sørensen, Søren Johannes
2009-01-01
available within that environment. Here we use the term supergenome to describe the set of all genes that a prokaryotic ‘individual' can draw on within a particular environmental setting. Conjugative plasmids can be considered particularly successful entities within the communal pool, which have enabled HGT...... over large taxonomic distances. These plasmids are collections of discrete regions of genes that function as ‘backbone modules' to undertake different aspects of overall plasmid maintenance and propagation. Conjugative plasmids often carry suites of ‘accessory elements' that contribute adaptive traits...... to the hosts and, potentially, other resident prokaryotes within specific environmental niches. Insight into the evolution of plasmid modules therefore contributes to our knowledge of gene dissemination and evolution within prokaryotic communities. This communal pool provides the prokaryotes with an important...
Electrochromic in conjugated polymers
International Nuclear Information System (INIS)
Picado Valenzuela, Alfredo
2007-01-01
This revision considered object the description of one of the materials with the greatest potential in the field of electrochromic (mainly in the visible region): the conjugated polymers (CP), area of enormous potential both now and in a short time ahead. The CP are insulating materials and organic semiconductors in a state not doped. They can be doped positively or negatively being observed a significant increase in the conductivity and being generated a color change in these materials. The understanding of how optical properties vary based on the chemical structure of the polymer or its mixtures and more precisely of the alternatives that can be entered into the conjugated system or π system to obtain a material that besides to be flexible, environmentally stable, presents the colored states. The revision was centred chiefly in the polypyrrole (Ppy), the polythiophene (PTh) and their derivatives such as poly (3.4-ethylenedioxythiophene) (PEDOT). The advantage of using monomers with variable structure, to adjust the composition of the copolymer, or to blend with the PC, allows to obtain a variety of colored states that can be modulated through the visible spectrum and even with applications to wavelengths outside of this region. Because the PC presented at least two different colored states can be varied continuously as a function of the voltage applied. In some cases, they may submit multicoloured statements, which offers a range of possibilities for their application in flexible electronic devices type screens and windows. Applications include smart windows, camouflage clothing and data screens. This type of material is emerging as one of the substitutes of the traditional inorganic semiconductor, with the advantage of its low cost, high flexibility and the possibility to generate multiple colors through the handling of the monomers in the structure and control of energy of his band gap. (author) [es
Generalized conjugate gradient squared
Energy Technology Data Exchange (ETDEWEB)
Fokkema, D.R.; Sleijpen, G.L.G. [Utrecht Univ. (Netherlands)
1994-12-31
In order to solve non-symmetric linear systems of equations, the Conjugate Gradient Squared (CGS) is a well-known and widely used iterative method. In practice the method converges fast, often twice as fast as the Bi-Conjugate Gradient method. This is what you may expect, since CGS uses the square of the BiCG polynomial. However, CGS may suffer from its erratic convergence behavior. The method may diverge or the approximate solution may be inaccurate. BiCGSTAB uses the BiCG polynomial and a product of linear factors in an attempt to smoothen the convergence. In many cases, this has proven to be very effective. Unfortunately, the convergence of BiCGSTAB may stall when a linear factor (nearly) degenerates. BiCGstab({ell}) is designed to overcome this degeneration of linear factors. It generalizes BiCGSTAB and uses both the BiCG polynomial and a product of higher order factors. Still, CGS may converge faster than BiCGSTAB or BiCGstab({ell}). So instead of using a product of linear or higher order factors, it may be worthwhile to look for other polynomials. Since the BiCG polynomial is based on a three term recursion, a natural choice would be a polynomial based on another three term recursion. Possibly, a suitable choice of recursion coefficients would result in method that converges faster or as fast as CGS, but less erratic. It turns out that an algorithm for such a method can easily be formulated. One particular choice for the recursion coefficients leads to CGS. Therefore one could call this algorithm generalized CGS. Another choice for the recursion coefficients leads to BiCGSTAB. It is therefore possible to mix linear factors and some polynomial based on a three term recursion. This way one may get the best of both worlds. The authors will report on their findings.
Reciprocity and conjugation fidelity in double phase conjugate mirrors
Delaye, Philippe; Fotiadi, Andrei A.; Roosen, Gerald
1999-09-01
It is well known that the conservation of energy in an optical system can be described by an invariant (intensity of the optical wave) during propagation. We identically show that reciprocity can be described by an invariant. This invariant is the overlap integral of two counterpropagating waves, that stays constant in every place of a reciprocal optical system. Applied to the double phase conjugate mirror (DPCM) this invariant can be rewritten as an equality between the ratio of the conjugation fidelity of the two ports of the DPCM and the ratio of the transmission in intensity of the two beams. If restricted to a plane wave case this relation becomes the well known equality of the diffraction efficiencies in both directions. We have implemented an experimental set-up that allows to show that the double phase conjugate mirror is reciprocal what confirms all the above discussion. We use the same set-up to measure the conjugation fidelity of the DPCM.
Finite strain discrete dislocation plasticity
Deshpande, VS; Needleman, A; Van der Giessen, E
2003-01-01
A framework for carrying out finite deformation discrete dislocation plasticity calculations is presented. The discrete dislocations are presumed to be adequately represented by the singular linear elastic fields so that the large deformations near dislocation cores are not modeled. The finite
Multiscale expansions in discrete world
Indian Academy of Sciences (India)
... multiscale expansions discretely. The power of this manageable method is confirmed by applying it to two selected nonlinear Schrödinger evolution equations. This approach can also be applied to other nonlinear discrete evolution equations. All the computations have been made with Maple computer packet program.
Multiscale expansions in discrete world
Indian Academy of Sciences (India)
This approach can also be applied to other nonlinear discrete evolution equations. All the computations have been made with Maple computer packet program. Keywords. Multiscale expansion; discrete evolution equation; modified nonlinear Schrödinger equation; third-order nonlinear Schrödinger equation; KdV equation.
Discrete Mathematics and Its Applications
Oxley, Alan
2010-01-01
The article gives ideas that lecturers of undergraduate Discrete Mathematics courses can use in order to make the subject more interesting for students and encourage them to undertake further studies in the subject. It is possible to teach Discrete Mathematics with little or no reference to computing. However, students are more likely to be…
Modern approaches to discrete curvature
Romon, Pascal
2017-01-01
This book provides a valuable glimpse into discrete curvature, a rich new field of research which blends discrete mathematics, differential geometry, probability and computer graphics. It includes a vast collection of ideas and tools which will offer something new to all interested readers. Discrete geometry has arisen as much as a theoretical development as in response to unforeseen challenges coming from applications. Discrete and continuous geometries have turned out to be intimately connected. Discrete curvature is the key concept connecting them through many bridges in numerous fields: metric spaces, Riemannian and Euclidean geometries, geometric measure theory, topology, partial differential equations, calculus of variations, gradient flows, asymptotic analysis, probability, harmonic analysis, graph theory, etc. In spite of its crucial importance both in theoretical mathematics and in applications, up to now, almost no books have provided a coherent outlook on this emerging field.
Liu, Mingjuan; Hummer, B Timothy; Li, Xiaoling; Hassel, Bret A
2004-11-01
Interferon (IFN)-stimulated gene (15 kDa) (ISG15) is a ubiquitin-like protein that forms covalent conjugates with cellular proteins. ISG15 is induced by IFN, microbial challenge, and p53, suggesting that it represents a genetic response that is shared among diverse stress stimuli. To investigate the regulation of this posttranslational modification pathway by a genotoxic chemotherapeutic agent, we examined ISG15 induction and conjugation in cells treated with the topoisomerase I (topoI) poison, camptothecin (CPT). CPT induced ISG15mRNA, and induction required protein synthesis and a functional p53 protein. However, IFN and the Jak-Stat components of the IFN signaling pathway were dispensable for CPT induction of ISG15. CPT induced free ISG15 and conjugates in a dose-dependent and time-dependent manner. A single 55-kDa protein was the prominent CPT-induced ISG15 conjugate and localized to the nuclear compartment. CPT-induced ISG15 conjugates were distinct from those induced by IFN; however, CPT treatment dramatically enhanced ISG15 conjugation in response to IFN. These findings provide the first evidence of a stimulus-specific induction of discrete ISG15 conjugate species and demonstrate that treatment with a combination of cancer therapeutic agents can cooperate to enhance ISG15 conjugation. Identification of the specific ISG15 conjugates induced by chemotherapeutic agents may reveal novel molecular targets.
Sequential measurements of conjugate observables
Energy Technology Data Exchange (ETDEWEB)
Carmeli, Claudio [Dipartimento di Fisica, Universita di Genova, Via Dodecaneso 33, 16146 Genova (Italy); Heinosaari, Teiko [Department of Physics and Astronomy, Turku Centre for Quantum Physics, University of Turku, 20014 Turku (Finland); Toigo, Alessandro, E-mail: claudio.carmeli@gmail.com, E-mail: teiko.heinosaari@utu.fi, E-mail: alessandro.toigo@polimi.it [Dipartimento di Matematica ' Francesco Brioschi' , Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)
2011-07-15
We present a unified treatment of sequential measurements of two conjugate observables. Our approach is to derive a mathematical structure theorem for all the relevant covariant instruments. As a consequence of this result, we show that every Weyl-Heisenberg covariant observable can be implemented as a sequential measurement of two conjugate observables. This method is applicable both in finite- and infinite-dimensional Hilbert spaces, therefore covering sequential spin component measurements as well as position-momentum sequential measurements.
Protein carriers of conjugate vaccines
Pichichero, Michael E
2013-01-01
The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of the past to T cell-dependent antigenic vaccines that were much more immunogenic and launched a renaissance in vaccinology. This review discusses the conjugate vaccines for prevention of infections caused by Hemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis. Specifically, the characteristics of the proteins used in the construction of the vaccines including CRM, tetanus toxoid, diphtheria toxoid, Neisseria meningitidis outer membrane complex, and Hemophilus influenzae protein D are discussed. The studies that established differences among and key features of conjugate vaccines including immunologic memory induction, reduction of nasopharyngeal colonization and herd immunity, and antibody avidity and avidity maturation are presented. Studies of dose, schedule, response to boosters, of single protein carriers with single and multiple polysaccharides, of multiple protein carriers with multiple polysaccharides and conjugate vaccines administered concurrently with other vaccines are discussed along with undesirable consequences of conjugate vaccines. The clear benefits of conjugate vaccines in improving the protective responses of the immature immune systems of young infants and the senescent immune systems of the elderly have been made clear and opened the way to development of additional vaccines using this technology for future vaccine products. PMID:23955057
Discrete dynamics versus analytic dynamics
DEFF Research Database (Denmark)
Toxværd, Søren
2014-01-01
For discrete classical Molecular dynamics obtained by the “Verlet” algorithm (VA) with the time increment h there exists a shadow Hamiltonian H˜ with energy E˜(h) , for which the discrete particle positions lie on the analytic trajectories for H˜ . Here, we proof that there, independent of such a......For discrete classical Molecular dynamics obtained by the “Verlet” algorithm (VA) with the time increment h there exists a shadow Hamiltonian H˜ with energy E˜(h) , for which the discrete particle positions lie on the analytic trajectories for H˜ . Here, we proof that there, independent...... of such an analytic analogy, exists an exact hidden energy invariance E * for VA dynamics. The fact that the discrete VA dynamics has the same invariances as Newtonian dynamics raises the question, which of the formulations that are correct, or alternatively, the most appropriate formulation of classical dynamics....... In this context the relation between the discrete VA dynamics and the (general) discrete dynamics investigated by Lee [Phys. Lett. B122, 217 (1983)] is presented and discussed....
Conjugated Fatty Acid Synthesis
Rawat, Richa; Yu, Xiao-Hong; Sweet, Marie; Shanklin, John
2012-01-01
Conjugated linolenic acids (CLNs), 18:3 Δ9,11,13, lack the methylene groups found between the double bonds of linolenic acid (18:3 Δ9,12,15). CLNs are produced by conjugase enzymes that are homologs of the oleate desaturases FAD2. The goal of this study was to map the domain(s) within the Momordica charantia conjugase (FADX) responsible for CLN formation. To achieve this, a series of Momordica FADX-Arabidopsis FAD2 chimeras were expressed in the Arabidopsis fad3fae1 mutant, and the transformed seeds were analyzed for the accumulation of CLN. These experiments identified helix 2 and the first histidine box as a determinant of conjugase product partitioning into punicic acid (18:3 Δ9cis,11trans,13cis) or α-eleostearic acid (18:3 Δ9cis,11trans,13trans). This was confirmed by analysis of a FADX mutant containing six substitutions in which the sequence of helix 2 and first histidine box was converted to that of FAD2. Each of the six FAD2 substitutions was individually converted back to the FADX equivalent identifying residues 111 and 115, adjacent to the first histidine box, as key determinants of conjugase product partitioning. Additionally, expression of FADX G111V and FADX G111V/D115E resulted in an approximate doubling of eleostearic acid accumulation to 20.4% and 21.2%, respectively, compared with 9.9% upon expression of the native Momordica FADX. Like the Momordica conjugase, FADX G111V and FADX D115E produced predominantly α-eleostearic acid and little punicic acid, but the FADX G111V/D115E double mutant produced approximately equal amounts of α-eleostearic acid and its isomer, punicic acid, implicating an interactive effect of residues 111 and 115 in punicic acid formation. PMID:22451660
Exact analysis of discrete data
Hirji, Karim F
2005-01-01
Researchers in fields ranging from biology and medicine to the social sciences, law, and economics regularly encounter variables that are discrete or categorical in nature. While there is no dearth of books on the analysis and interpretation of such data, these generally focus on large sample methods. When sample sizes are not large or the data are otherwise sparse, exact methods--methods not based on asymptotic theory--are more accurate and therefore preferable.This book introduces the statistical theory, analysis methods, and computation techniques for exact analysis of discrete data. After reviewing the relevant discrete distributions, the author develops the exact methods from the ground up in a conceptually integrated manner. The topics covered range from univariate discrete data analysis, a single and several 2 x 2 tables, a single and several 2 x K tables, incidence density and inverse sampling designs, unmatched and matched case -control studies, paired binary and trinomial response models, and Markov...
Causal Dynamics of Discrete Surfaces
Directory of Open Access Journals (Sweden)
Pablo Arrighi
2014-03-01
Full Text Available We formalize the intuitive idea of a labelled discrete surface which evolves in time, subject to two natural constraints: the evolution does not propagate information too fast; and it acts everywhere the same.
Research study of conjugate materials; Conjugate material no chosa kenkyu
Energy Technology Data Exchange (ETDEWEB)
NONE
1998-03-01
The paper reported an introductory research on possibilities of new glass `conjugate materials.` The report took up the structure and synthetic process of conjugate materials to be researched/developed, classified them according to structural elements on molecular, nanometer and cluster levels, and introduced the structures and functions. Further, as glasses with new functions to be proposed, the paper introduced transparent and high-strength glass used for houses and vehicles, light modulation glass which realizes energy saving and optical data processing, and environmentally functional glass which realizes environmental cleaning or high performance biosensor. An initial survey was also conducted on rights of intellectual property to be taken notice of in Japan and abroad in the present situation. Reports were summed up and introduced of Osaka National Research Institute, Electrotechnical Laboratory, and National Industrial Research Institute of Nagoya which are all carrying out leading studies of conjugate materials. 235 refs., 135 figs., 6 tabs.
Alfa, Attahiru S
2016-01-01
This book introduces the theoretical fundamentals for modeling queues in discrete-time, and the basic procedures for developing queuing models in discrete-time. There is a focus on applications in modern telecommunication systems. It presents how most queueing models in discrete-time can be set up as discrete-time Markov chains. Techniques such as matrix-analytic methods (MAM) that can used to analyze the resulting Markov chains are included. This book covers single node systems, tandem system and queueing networks. It shows how queues with time-varying parameters can be analyzed, and illustrates numerical issues associated with computations for the discrete-time queueing systems. Optimal control of queues is also covered. Applied Discrete-Time Queues targets researchers, advanced-level students and analysts in the field of telecommunication networks. It is suitable as a reference book and can also be used as a secondary text book in computer engineering and computer science. Examples and exercises are includ...
Conjugated polymer nanoparticles, methods of using, and methods of making
Habuchi, Satoshi
2017-03-16
Embodiments of the present disclosure provide for conjugated polymer nanoparticle, method of making conjugated polymer nanoparticles, method of using conjugated polymer nanoparticle, polymers, and the like.
Antibody Drug Conjugates: Preclinical Considerations.
Bornstein, Gadi G
2015-05-01
The development path for antibody drug conjugates (ADCs) is more complex and challenging than for unmodified antibodies. While many of the preclinical considerations for both unmodified and antibody drug conjugates are shared, special considerations must be taken into account when developing an ADC. Unlike unmodified antibodies, an ADC must preferentially bind to tumor cells, internalize, and traffic to the appropriate intracellular compartment to release the payload. Parameters that can impact the pharmacological properties of this class of therapeutics include the selection of the payload, the type of linker, and the methodology for payload drug conjugation. Despite a plethora of in vitro assays and in vivo models to screen and evaluate ADCs, the challenge remains to develop improved preclinical tools that will be more predictive of clinical outcome. This review will focus on preclinical considerations for clinically validated small molecule ADCs. In addition, the lessons learned from Mylotarg®, the first in class FDA-approved ADC, are highlighted.
Persistence Mechanisms of Conjugative Plasmids
DEFF Research Database (Denmark)
Bahl, Martin Iain; Hansen, Lars H.; Sørensen, Søren Johannes
2009-01-01
maintenance in the host cell. These importantly include the ability to self-mobilize in a process termed conjugative transfer, which may occur across species barriers. Other plasmid stabilizing mechanisms include the multimer resolution system, active partitioning, and post-segregational-killing of plasmid......Are plasmids selfish parasitic DNA molecules or an integrated part of the bacterial genome? This chapter reviews the current understanding of the persistence mechanisms of conjugative plasmids harbored by bacterial cells and populations. The diversity and intricacy of mechanisms affecting...... the successful propagation and long-term continued existence of these extra-chromosomal elements is extensive. Apart from the accessory genetic elements that may provide plasmid-harboring cells a selective advantage, special focus is placed on the mechanisms conjugative plasmids employ to ensure their stable...
Discrete Curvature Theories and Applications
Sun, Xiang
2016-08-25
Discrete Di erential Geometry (DDG) concerns discrete counterparts of notions and methods in di erential geometry. This thesis deals with a core subject in DDG, discrete curvature theories on various types of polyhedral surfaces that are practically important for free-form architecture, sunlight-redirecting shading systems, and face recognition. Modeled as polyhedral surfaces, the shapes of free-form structures may have to satisfy di erent geometric or physical constraints. We study a combination of geometry and physics { the discrete surfaces that can stand on their own, as well as having proper shapes for the manufacture. These proper shapes, known as circular and conical meshes, are closely related to discrete principal curvatures. We study curvature theories that make such surfaces possible. Shading systems of freeform building skins are new types of energy-saving structures that can re-direct the sunlight. From these systems, discrete line congruences across polyhedral surfaces can be abstracted. We develop a new curvature theory for polyhedral surfaces equipped with normal congruences { a particular type of congruences de ned by linear interpolation of vertex normals. The main results are a discussion of various de nitions of normality, a detailed study of the geometry of such congruences, and a concept of curvatures and shape operators associated with the faces of a triangle mesh. These curvatures are compatible with both normal congruences and the Steiner formula. In addition to architecture, we consider the role of discrete curvatures in face recognition. We use geometric measure theory to introduce the notion of asymptotic cones associated with a singular subspace of a Riemannian manifold, which is an extension of the classical notion of asymptotic directions. We get a simple expression of these cones for polyhedral surfaces, as well as convergence and approximation theorems. We use the asymptotic cones as facial descriptors and demonstrate the
A parallel algorithm for solving the integral form of the discrete ordinates equations
International Nuclear Information System (INIS)
Zerr, R. J.; Azmy, Y. Y.
2009-01-01
The integral form of the discrete ordinates equations involves a system of equations that has a large, dense coefficient matrix. The serial construction methodology is presented and properties that affect the execution times to construct and solve the system are evaluated. Two approaches for massively parallel implementation of the solution algorithm are proposed and the current results of one of these are presented. The system of equations May be solved using two parallel solvers-block Jacobi and conjugate gradient. Results indicate that both methods can reduce overall wall-clock time for execution. The conjugate gradient solver exhibits better performance to compete with the traditional source iteration technique in terms of execution time and scalability. The parallel conjugate gradient method is synchronous, hence it does not increase the number of iterations for convergence compared to serial execution, and the efficiency of the algorithm demonstrates an apparent asymptotic decline. (authors)
Phase conjugation of acoustic beams
Bunkin, F. V.; Vlasov, D. V.; Kravtsov, Iu. A.
The paper presents a classification of methods for the phase conjugation (PC) of wave fields of various physical natures on the basis of such nonliner interactions as stimulated scattering, and three- and four-wave interactions. Among the latter, attention is given to holographic (volume and surface) and parametric PC schemes, permitting PC with amplification. The possibility of developing phase-conjugated devices using acoustic PC devices on the basis of various nonlinear effects is considered. Experimental results pertaining to the PC of sound fields are presented, and possible applications of acoustic PC devices are indicated.
Analysis of Discrete Mittag - Leffler Functions
Directory of Open Access Journals (Sweden)
N. Shobanadevi
2015-03-01
Full Text Available Discrete Mittag - Leffler functions play a major role in the development of the theory of discrete fractional calculus. In the present article, we analyze qualitative properties of discrete Mittag - Leffler functions and establish sufficient conditions for convergence, oscillation and summability of the infinite series associated with discrete Mittag - Leffler functions.
Chaos in discrete fractional difference equations
Indian Academy of Sciences (India)
2016-09-07
Sep 7, 2016 ... logistics map and discrete sine map [14,15]. In this paper, we analyse numerically the chaotic behaviour of three maps viz., discrete tent map, discrete 2x(mod1) map and discrete Gauss map. Study of these maps is important as they are standard one-dimensional maps, well known to show characteristic ...
Foundations of a discrete physics
International Nuclear Information System (INIS)
McGoveran, D.; Noyes, P.
1988-01-01
Starting from the principles of finiteness, discreteness, finite computability and absolute nonuniqueness, we develop the ordering operator calculus, a strictly constructive mathematical system having the empirical properties required by quantum mechanical and special relativistic phenomena. We show how to construct discrete distance functions, and both rectangular and spherical coordinate systems(with a discrete version of ''π''). The richest discrete space constructible without a preferred axis and preserving translational and rotational invariance is shown to be a discrete 3-space with the usual symmetries. We introduce a local ordering parameter with local (proper) time-like properties and universal ordering parameters with global (cosmological) time-like properties. Constructed ''attribute velocities'' connect ensembles with attributes that are invariant as the appropriate time-like parameter increases. For each such attribute, we show how to construct attribute velocities which must satisfy the '' relativistic Doppler shift'' and the ''relativistic velocity composition law,'' as well as the Lorentz transformations. By construction, these velocities have finite maximum and minimum values. In the space of all attributes, the minimum of these maximum velocities will predominate in all multiple attribute computations, and hence can be identified as a fundamental limiting velocity, General commutation relations are constructed which under the physical interpretation are shown to reduce to the usual quantum mechanical commutation relations. 50 refs., 18 figs
High pressure structural studies of conjugated molecules
DEFF Research Database (Denmark)
Knaapila, Matti; Torkkeli, Mika; Scherf, Ullrich
2018-01-01
This chapter highlights high pressure GPa level structural studies of conjugated polymers and their analogues: conjugated oligomers and molecules, and rigid rod polymers. Attention is placed on our recent studies of polyfluorenes.......This chapter highlights high pressure GPa level structural studies of conjugated polymers and their analogues: conjugated oligomers and molecules, and rigid rod polymers. Attention is placed on our recent studies of polyfluorenes....
Degree distribution in discrete case
International Nuclear Information System (INIS)
Wang, Li-Na; Chen, Bin; Yan, Zai-Zai
2011-01-01
Vertex degree of many network models and real-life networks is limited to non-negative integer. By means of measure and integral, the relation of the degree distribution and the cumulative degree distribution in discrete case is analyzed. The degree distribution, obtained by the differential of its cumulative, is only suitable for continuous case or discrete case with constant degree change. When degree change is not a constant but proportional to degree itself, power-law degree distribution and its cumulative have the same exponent and the mean value is finite for power-law exponent greater than 1. -- Highlights: → Degree change is the crux for using the cumulative degree distribution method. → It suits for discrete case with constant degree change. → If degree change is proportional to degree, power-law degree distribution and its cumulative have the same exponent. → In addition, the mean value is finite for power-law exponent greater than 1.
Geometry of discrete quantum computing
Hanson, Andrew J.; Ortiz, Gerardo; Sabry, Amr; Tai, Yu-Tsung
2013-05-01
Conventional quantum computing entails a geometry based on the description of an n-qubit state using 2n infinite precision complex numbers denoting a vector in a Hilbert space. Such numbers are in general uncomputable using any real-world resources, and, if we have the idea of physical law as some kind of computational algorithm of the universe, we would be compelled to alter our descriptions of physics to be consistent with computable numbers. Our purpose here is to examine the geometric implications of using finite fields Fp and finite complexified fields \\mathbf {F}_{p^2} (based on primes p congruent to 3 (mod4)) as the basis for computations in a theory of discrete quantum computing, which would therefore become a computable theory. Because the states of a discrete n-qubit system are in principle enumerable, we are able to determine the proportions of entangled and unentangled states. In particular, we extend the Hopf fibration that defines the irreducible state space of conventional continuous n-qubit theories (which is the complex projective space \\mathbf {CP}^{2^{n}-1}) to an analogous discrete geometry in which the Hopf circle for any n is found to be a discrete set of p + 1 points. The tally of unit-length n-qubit states is given, and reduced via the generalized Hopf fibration to \\mathbf {DCP}^{2^{n}-1}, the discrete analogue of the complex projective space, which has p^{2^{n}-1} (p-1)\\,\\prod _{k=1}^{n-1} ( p^{2^{k}}+1) irreducible states. Using a measure of entanglement, the purity, we explore the entanglement features of discrete quantum states and find that the n-qubit states based on the complexified field \\mathbf {F}_{p^2} have pn(p - 1)n unentangled states (the product of the tally for a single qubit) with purity 1, and they have pn + 1(p - 1)(p + 1)n - 1 maximally entangled states with purity zero.
Enhanced photophysics of conjugated polymers
Chen, Liaohai [Darien, IL
2007-06-12
A particulate fluorescent conjugated polymer surfactant complex and method of making and using same. The particles are between about 15 and about 50 nm and when formed from a lipsome surfactant have a charge density similar to DNA and are strongly absorbed by cancer cells.
Conjugal Pairing in Escherichia Coli
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 8. Conjugal Pairing in Escherichia Coli. Joshua Lederberg. Classics Volume 13 Issue 8 August 2008 pp 793-794. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/013/08/0793-0794 ...
Galois conjugates of topological phases
Freedman, M. H.; Gukelberger, J.; Hastings, M. B.; Trebst, S.; Troyer, M.; Wang, Z.
2012-01-01
Galois conjugation relates unitary conformal field theories and topological quantum field theories (TQFTs) to their nonunitary counterparts. Here we investigate Galois conjugates of quantum double models, such as the Levin-Wen model. While these Galois-conjugated Hamiltonians are typically non-Hermitian, we find that their ground-state wave functions still obey a generalized version of the usual code property (local operators do not act on the ground-state manifold) and hence enjoy a generalized topological protection. The key question addressed in this paper is whether such nonunitary topological phases can also appear as the ground states of Hermitian Hamiltonians. Specific attempts at constructing Hermitian Hamiltonians with these ground states lead to a loss of the code property and topological protection of the degenerate ground states. Beyond this, we rigorously prove that no local change of basis can transform the ground states of the Galois-conjugated doubled Fibonacci theory into the ground states of a topological model whose Hermitian Hamiltonian satisfies Lieb-Robinson bounds. These include all gapped local or quasilocal Hamiltonians. A similar statement holds for many other nonunitary TQFTs. One consequence is that these nonunitary TQFTs do not describe physical realizations of topological phases. In particular, this implies that the “Gaffnian” wave function can not be the ground state of a gapped fractional quantum Hall state.
Conjugal Pairing in Escherichia Coli
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 8. Conjugal Pairing in Escherichia Coli. Joshua Lederberg. Classics Volume 13 Issue 8 August 2008 pp 793-794. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/013/08/0793-0794 ...
Bacteriophytochromes control conjugation in Agrobacterium fabrum.
Bai, Yingnan; Rottwinkel, Gregor; Feng, Juan; Liu, Yiyao; Lamparter, Tilman
2016-08-01
Bacterial conjugation, the transfer of single stranded plasmid DNA from donor to recipient cell, is mediated through the type IV secretion system. We performed conjugation assays using a transmissible artificial plasmid as reporter. With this assay, conjugation in Agrobacterium fabrum was modulated by the phytochromes Agp1 and Agp2, photoreceptors that are most sensitive in the red region of visible light. In conjugation studies with wild-type donor cells carrying a pBIN-GUSINT plasmid as reporter that lacked the Ti (tumor inducing) plasmid, no conjugation was observed. When either agp1(-) or agp2(-) knockout donor strains were used, plasmid DNA was delivered to the recipient, indicating that both phytochromes suppress conjugation in the wild type donor. In the recipient strains, the loss of Agp1 or Agp2 led to diminished conjugation. When wild type cells with Ti plasmid and pBIN-GUS reporter plasmid were used as donor, a high rate of conjugation was observed. The DNA transfer was down regulated by red or far-red light by a factor of 3.5. With agp1(-) or agp2(-) knockout donor cells, conjugation in the dark was about 10 times lower than with the wild type donor, and with the double knockout donor no conjugation was observed. These results imply that the phytochrome system has evolved to inhibit conjugation in the light. The decrease of conjugation under different temperature correlated with the decrease of phytochrome autophosphorylation. Copyright © 2015 Elsevier B.V. All rights reserved.
REVIEW ARTICLE Conjugated Hyperbilirubinaemia in Early Infancy ...
African Journals Online (AJOL)
REVIEW ARTICLE Conjugated Hyperbilirubinaemia in Early Infancy. AOK Johnson. Abstract. Conjugated hyperbilirubinaemia exists when the conjugated serum bilirubin level is more than 2 mg/dl or more than 20 per cent of the total serum bilirubin. It is always pathological in early infancy. The causes are many and diverse ...
Pastuszak, Jakub; Waclaw, Bartlomiej
2017-01-01
Conjugation is a process in which bacteria exchange DNA through a physical connection (conjugative junction) between mating cells. Despite its significance for processes such as the spread of antibiotic resistance, the role of physical forces in conjugation is poorly understood. Here we use computer models to show that the conjugative junction not only serves as a link to transfer the DNA but it also mechanically stabilises the mating pair which significantly increases the conjugation rate. W...
The remarkable discreteness of being
Indian Academy of Sciences (India)
2014-03-15
Mar 15, 2014 ... atomistic theory and give a simple, elegant explanation to all these laws. Around 1900 AD, Planck, ... In none of the cases reviewed here is it claimed that a simple discrete theory will explain all the phenomena. ..... of migration a decreasing function of the distance; (iii) due to random sampling from one ...
Path integrals as discrete sums
Bitar, Khalil; Khuri, N. N.; Ren, H. C.
1991-08-01
We present a new formulation of Feynman's path integral, based on Voronin's theorems on the universality of the Riemann zeta function. The result is a discrete sum over ``paths,'' each given by a zeta function. A new measure which leads to the correct quantum mechanics is explicitly given.
Multiscale expansions in discrete world
Indian Academy of Sciences (India)
Multiscale expansions in discrete world. ÖMER ÜNSAL, FILIZ TASCAN. ∗ and MEHMET NACI ÖZER. Eskisehir Osmangazi University, Art-Science Faculty, Department of Mathematics and Computer. Sciences, Eskisehir-Türkiye. ∗. Corresponding author. E-mail: ftascan@ogu.edu.tr. MS received 12 April 2013; accepted 16 ...
The remarkable discreteness of being
Indian Academy of Sciences (India)
2014-03-15
Mar 15, 2014 ... ... examples where these facts play, or could play, important roles: the spatial distribution of species, the structuring of biodiversity and the. (Darwinian) evolution of altruistic behaviour. [Houchmandzadeh B 2014 The remarkable discreteness of being. J. Biosci. 39 249–258] DOI 10.1007/s12038-013-9350-7.
The remarkable discreteness of being
Indian Academy of Sciences (India)
Life is a discrete, stochastic phenomenon: for a biological organism, the time of the two most important events of its life (reproduction and death) is random and these events change the number of individuals of the species by single units. These facts can have surprising, counterintuitive consequences. I review here three ...
Discrete tomography in neutron radiography
International Nuclear Information System (INIS)
Kuba, Attila; Rodek, Lajos; Kiss, Zoltan; Rusko, Laszlo; Nagy, Antal; Balasko, Marton
2005-01-01
Discrete tomography (DT) is an imaging technique for reconstructing discrete images from their projections using the knowledge that the object to be reconstructed contains only a few homogeneous materials characterized by known discrete absorption values. One of the main reasons for applying DT is that we will hopefully require relatively few projections. Using discreteness and some a priori information (such as an approximate shape of the object) we can apply two DT methods in neutron imaging by reducing the problem to an optimization task. The first method is a special one because it is only suitable if the object is composed of cylinders and sphere shapes. The second method is a general one in the sense that it can be used for reconstructing objects of any shape. Software was developed and physical experiments performed in order to investigate the effects of several reconstruction parameters: the number of projections, noise levels, and complexity of the object to be reconstructed. We give a summary of the experimental results and make a comparison of the results obtained using a classical reconstruction technique (FBP). The programs we developed are available in our DT reconstruction program package DIRECT
TAT Peptide and Its Conjugates: Proteolytic Stability
Grunwald, Jacob; Rejtar, Tomas; Sawant, Rupa; Wang, Zhouxi; Torchilin, Vladimir P.
2009-01-01
The proteolytic cleavage of TATp, TATp-PEG1000-PE conjugate (TATp-conjugate), and TATp as TATp-conjugate in mixed micelles made of TATp-conjugate and PEG5000-PE (2.5% mol of TATp-conjugate, TATp-Mic) were studied by HPLC with fluorescent detection using fluorenylmethyl chloroformate (FMOC) labeling and by MALDI-TOF MS analysis. The cleavage kinetics were analyzed in human blood plasma and in trypsin-containing phosphate buffered saline (PBS), pH 7.4, to simulate the proteolytic activity of hu...
Bayesian inference from count data using discrete uniform priors.
Comoglio, Federico; Fracchia, Letizia; Rinaldi, Maurizio
2013-01-01
We consider a set of sample counts obtained by sampling arbitrary fractions of a finite volume containing an homogeneously dispersed population of identical objects. We report a Bayesian derivation of the posterior probability distribution of the population size using a binomial likelihood and non-conjugate, discrete uniform priors under sampling with or without replacement. Our derivation yields a computationally feasible formula that can prove useful in a variety of statistical problems involving absolute quantification under uncertainty. We implemented our algorithm in the R package dupiR and compared it with a previously proposed Bayesian method based on a Gamma prior. As a showcase, we demonstrate that our inference framework can be used to estimate bacterial survival curves from measurements characterized by extremely low or zero counts and rather high sampling fractions. All in all, we provide a versatile, general purpose algorithm to infer population sizes from count data, which can find application in a broad spectrum of biological and physical problems.
Conjugated Polymers for Energy Production
DEFF Research Database (Denmark)
Livi, Francesco
for scalable PSCs fully printed under ambient conditions [Adv. Energy Mater. 2015, 5, 1402186]. PPDTBT resulted to be the conjugated polymer with the best photovoltaic performance within the 104 synthesized macromolecules. Therefore, further studies have been done on such material. The impact of side chain......This dissertation is aimed at developing materials for flexible, large area, ITO-free polymer solar cells (PSCs) fully printed under ambient conditions. A large screening of conjugated polymers, both novel and well-known materials, has been carried out in order to find suitable candidates.......The reactivity of DArP has been further studied and applied to the synthesis of fluorinated copolymers featuring thiophene, which are largely used materials for organic electronics. In particular, by moving the bromine functionality from one monomer to the other, a big impact on the reactivity has been observed...
Organometallic B12-DNA conjugate
DEFF Research Database (Denmark)
Hunger, Miriam; Mutti, Elena; Rieder, Alexander
2014-01-01
Design, synthesis, and structural characterization of a B12-octadecanucleotide are presented herein, a new organometallic B12-DNA conjugate. In such covalent conjugates, the natural B12 moiety may be a versatile vector for controlled in vivo delivery of oligonucleotides to cellular targets...... with transcobalamin (TC), but not so efficient with the homologous glycoproteins intrinsic factor and haptocorrin. Binding of the B12 octadecanucleotide to TC suggests the capacity of the B12 moiety to serve as a natural vector for specific transport of single stranded, organometallic oligonucleotide loads from...... in humans and animals, through the endogenous B12 transport systems. Binding of the organometallic B12 octadecanucleotide to the three important human proteins of B12 transport was studied, to examine its structural suitability for the task of eventual in vivo oligonucleotide delivery. Binding was efficient...
Discrete compactons: some exact results
International Nuclear Information System (INIS)
Kevrekidis, P G; Konotop, V V; Bishop, A R; Takeno, S
2002-01-01
In this letter, we use the method of constructing exact solutions on lattices proposed by Kinnersley and described in Schmidt (1979 Phys. Rev. B 20 4397), to obtain exact compacton solutions in discrete models. We examine the linear stability of such solutions, both for the bright compacton and for the dark compacton cases. We focus on a 'quantization condition' that the width of the profile should satisfy. We also use this quantization condition to examine the possibility of compact coherent structures travelling in discrete settings. Our results are obtained for sinusoidal profiles and then generalized to elliptic functions of arbitrary modulus. The possibility of multi-compacton solutions is considered. (letter to the editor)
Discrete mathematics using a computer
Hall, Cordelia
2000-01-01
Several areas of mathematics find application throughout computer science, and all students of computer science need a practical working understanding of them. These core subjects are centred on logic, sets, recursion, induction, relations and functions. The material is often called discrete mathematics, to distinguish it from the traditional topics of continuous mathematics such as integration and differential equations. The central theme of this book is the connection between computing and discrete mathematics. This connection is useful in both directions: • Mathematics is used in many branches of computer science, in applica tions including program specification, datastructures,design and analysis of algorithms, database systems, hardware design, reasoning about the correctness of implementations, and much more; • Computers can help to make the mathematics easier to learn and use, by making mathematical terms executable, making abstract concepts more concrete, and through the use of software tools su...
Discrete dynamics of complex systems
Directory of Open Access Journals (Sweden)
Hermann Haken
1997-01-01
Full Text Available This article extends the slaving principle of synergetics to processes with discrete time steps. Starting point is a set of nonlinear difference equations which contain multiplicative noise and which refer to multidimensional state vectors. The system depends on a control parameter. When its value is changed beyond a critical value, an instability of the solution occurs. The stability analysis allows us to divide the system into stable and unstable modes. The original equations can be transformed to a set of difference equations for the unstable and stable modes. The extension of the slaving principle to the time-discrete case then states that all the stable modes can be explicitly expressed by the unstable modes or so-called order-parameters.
Quantum chaos on discrete graphs
Energy Technology Data Exchange (ETDEWEB)
Smilansky, Uzy [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Isaac Newton Institute for Mathematical Sciences, 20 Clarkson Road, Cambridge CB3 0EH (United Kingdom)
2007-07-06
Adapting a method developed for the study of quantum chaos on quantum (metric) graphs (Kottos and Smilansky 1997 Phys. Rev. Lett. 79 4794, Kottos and Smilansky 1999 Ann. Phys., NY 274 76), spectral {zeta} functions and trace formulae for discrete Laplacians on graphs are derived. This is achieved by expressing the spectral secular equation in terms of the periodic orbits of the graph and obtaining functions which belong to the class of {zeta} functions proposed originally by Ihara (1966 J. Mat. Soc. Japan 18 219) and expanded by subsequent authors (Stark and Terras 1996 Adv. Math. 121 124, Kotani and Sunada 2000 J. Math. Sci. Univ. Tokyo 7 7). Finally, a model of 'classical dynamics' on the discrete graph is proposed. It is analogous to the corresponding classical dynamics derived for quantum graphs (Kottos and Smilansky 1997 Phys. Rev. Lett. 79 4794, Kottos and Smilansky 1999 Ann. Phys., NY 274 76). (fast track communication)
Discrete symmetries in the MSSM
Energy Technology Data Exchange (ETDEWEB)
Schieren, Roland
2010-12-02
The use of discrete symmetries, especially abelian ones, in physics beyond the standard model of particle physics is discussed. A method is developed how a general, abelian, discrete symmetry can be obtained via spontaneous symmetry breaking. In addition, anomalies are treated in the path integral approach with special attention to anomaly cancellation via the Green-Schwarz mechanism. All this is applied to the minimal supersymmetric standard model. A unique Z{sup R}{sub 4} symmetry is discovered which solves the {mu}-problem as well as problems with proton decay and allows to embed the standard model gauge group into a simple group, i.e. the Z{sup R}{sub 4} is compatible with grand unification. Also the flavor problem in the context of minimal flavor violation is addressed. Finally, a string theory model is presented which exhibits the mentioned Z{sup R}{sub 4} symmetry and other desirable features. (orig.)
Applied geometry and discrete mathematics
Sturm; Gritzmann, Peter; Sturmfels, Bernd
1991-01-01
This volume, published jointly with the Association for Computing Machinery, comprises a collection of research articles celebrating the occasion of Victor Klee's sixty-fifth birthday in September 1990. During his long career, Klee has made contributions to a wide variety of areas, such as discrete and computational geometry, convexity, combinatorics, graph theory, functional analysis, mathematical programming and optimization, and theoretical computer science. In addition, Klee made important contributions to mathematics education, mathematical methods in economics and the decision sciences, applications of discrete mathematics in the biological and social sciences, and the transfer of knowledge from applied mathematics to industry. In honor of Klee's achievements, this volume presents more than forty papers on topics related to Klee's research. While the majority of the papers are research articles, a number of survey articles are also included. Mirroring the breadth of Klee's mathematical contributions, th...
Dark energy from discrete spacetime.
Trout, Aaron D
2013-01-01
Dark energy accounts for most of the matter-energy content of our universe, yet current theories of its origin rely on radical physical assumptions such as the holographic principle or controversial anthropic arguments. We give a better motivated explanation for dark energy, claiming that it arises from a small negative scalar-curvature present even in empty spacetime. The vacuum has this curvature because spacetime is fundamentally discrete and there are more ways for a discrete geometry to have negative curvature than positive. We explicitly compute this effect using a variant of the well known dynamical-triangulations (DT) model for quantum gravity. Our model predicts a time-varying non-zero cosmological constant with a current value, [Formula: see text] in natural units, in agreement with observation. This calculation is made possible by a novel characterization of the possible DT action values combined with numerical evidence concerning their degeneracies.
Discrete Choice and Rational Inattention
DEFF Research Database (Denmark)
Fosgerau, Mogens; Melo, Emerson; de Palma, André
2017-01-01
This paper establishes a general equivalence between discrete choice and rational inattention models. Matejka and McKay (2015, AER) showed that when information costs are modelled using the Shannon entropy, the result- ing choice probabilities in the rational inattention model take the multinomial...... logit form. We show that when information costs are modelled using a class of generalized entropies, then the choice probabilities in any rational inattention model are observationally equivalent to some additive random utility discrete choice model and vice versa. This equivalence arises from convex......- analytic properties of the random utility model. Thus any additive random utility model can be given an interpretation in terms of boundedly rational behavior. We provide examples of this equivalence utilizing the nested logit model, an empirically relevant random utility model allowing for flexible...
Duality for discrete integrable systems
International Nuclear Information System (INIS)
Quispel, G R W; Capel, H W; Roberts, J A G
2005-01-01
A new class of discrete dynamical systems is introduced via a duality relation for discrete dynamical systems with a number of explicitly known integrals. The dual equation can be defined via the difference of an arbitrary linear combination of integrals and its upshifted version. We give an example of an integrable mapping with two parameters and four integrals leading to a (four-dimensional) dual mapping with four parameters and two integrals. We also consider a more general class of higher-dimensional mappings arising via a travelling-wave reduction from the (integrable) MKdV partial-difference equation. By differencing the trace of the monodromy matrix we obtain a class of novel dual mappings which is shown to be integrable as level-set-dependent versions of the original ones
Discrete fractional solutions of a Legendre equation
Yılmazer, Resat
2018-01-01
One of the most popular research interests of science and engineering is the fractional calculus theory in recent times. Discrete fractional calculus has also an important position in fractional calculus. In this work, we acquire new discrete fractional solutions of the homogeneous and non homogeneous Legendre differential equation by using discrete fractional nabla operator.
On equivalence of discrete-discrete and continuum-discrete design sensitivity analysis
Choi, Kyung K.; Twu, Sung-Ling
1989-01-01
Developments in design sensitivity analysis (DSA) method have been made using two fundamentally different approaches as shown. In the first approach, a discretized structural finite element model is used to carry out DSA. There are three different methods in the discrete DSA approach: finite difference, semi-analytical, and analytical methods. The finite difference method is a popular one due to its simplicity, but a serious shortcoming of the method is the uncertainty in the choice of a perturbation step size of design variables. In the semi-analytical method, the derivatives of stiffness matrix is computed by finite differences, whereas in the analytical method, the derivatives are obtained analytically. For the shape design variable, computation of analytical derivative of stiffness matrix is quite costly. Because of this, the semi-analytical method is a popular choice in discrete shape DSA approach. However, recently, Barthelemy and Haftka presented that the semi-analytical method can have serious accuracy problems for shape design variables in structures modeled by beam, plate, truss, frame, and solid elements. They found that accuracy problems occur even for a simple cantilever beam. In the second approach, a continuum model of the structure is used to carry out DSA.
The Tcp conjugation system of Clostridium perfringens.
Wisniewski, Jessica A; Rood, Julian I
2017-05-01
The Gram-positive pathogen Clostridium perfringens possesses a family of large conjugative plasmids that is typified by the tetracycline resistance plasmid pCW3. Since these plasmids may carry antibiotic resistance genes or genes encoding extracellular or sporulation-associated toxins, the conjugative transfer of these plasmids appears to be important for the epidemiology of C. perfringens-mediated diseases. Sequence analysis of members of this plasmid family identified a highly conserved 35kb region that encodes proteins with various functions, including plasmid replication and partitioning. The tcp conjugation locus also was identified in this region, initially based on low-level amino acid sequence identity to conjugation proteins from the integrative conjugative element Tn916. Genetic studies confirmed that the tcp locus is required for conjugative transfer and combined with biochemical and structural analyses have led to the development of a functional model of the Tcp conjugation apparatus. This review summarises our current understanding of the Tcp conjugation system, which is now one of the best-characterized conjugation systems in Gram-positive bacteria. Copyright © 2017 Elsevier Inc. All rights reserved.
Chemistry of Oligonucleotibe-Gold Nanoparticle Conjugates
National Research Council Canada - National Science Library
Letsinger, Robert
2003-01-01
Conjugates prepared by immobilizing thiol-terminated oligonucleotides onto gold nanoparticles from stable colloidal solutions in aqueous media The oligo nucleotides can serve as linkers to organize...
Discrete geometric structures for architecture
Pottmann, Helmut
2010-06-13
The emergence of freeform structures in contemporary architecture raises numerous challenging research problems, most of which are related to the actual fabrication and are a rich source of research topics in geometry and geometric computing. The talk will provide an overview of recent progress in this field, with a particular focus on discrete geometric structures. Most of these result from practical requirements on segmenting a freeform shape into planar panels and on the physical realization of supporting beams and nodes. A study of quadrilateral meshes with planar faces reveals beautiful relations to discrete differential geometry. In particular, we discuss meshes which discretize the network of principal curvature lines. Conical meshes are among these meshes; they possess conical offset meshes at a constant face/face distance, which in turn leads to a supporting beam layout with so-called torsion free nodes. This work can be generalized to a variety of multilayer structures and laid the ground for an adapted curvature theory for these meshes. There are also efforts on segmenting surfaces into planar hexagonal panels. Though these are less constrained than planar quadrilateral panels, this problem is still waiting for an elegant solution. Inspired by freeform designs in architecture which involve circles and spheres, we present a new kind of triangle mesh whose faces\\' in-circles form a packing, i.e., the in-circles of two triangles with a common edge have the same contact point on that edge. These "circle packing (CP) meshes" exhibit an aesthetic balance of shape and size of their faces. They are closely tied to sphere packings on surfaces and to various remarkable structures and patterns which are of interest in art, architecture, and design. CP meshes constitute a new link between architectural freeform design and computational conformal geometry. Recently, certain timber structures motivated us to study discrete patterns of geodesics on surfaces. This
Radiative transfer on discrete spaces
Preisendorfer, Rudolph W; Stark, M; Ulam, S
1965-01-01
Pure and Applied Mathematics, Volume 74: Radiative Transfer on Discrete Spaces presents the geometrical structure of natural light fields. This book describes in detail with mathematical precision the radiometric interactions of light-scattering media in terms of a few well established principles.Organized into four parts encompassing 15 chapters, this volume begins with an overview of the derivations of the practical formulas and the arrangement of formulas leading to numerical solution procedures of radiative transfer problems in plane-parallel media. This text then constructs radiative tran
Subgap Absorption in Conjugated Polymers
Sinclair, M.; Seager, C. H.; McBranch, D.; Heeger, A. J; Baker, G. L.
1991-01-01
Along with X{sup (3)}, the magnitude of the optical absorption in the transparent window below the principal absorption edge is an important parameter which will ultimately determine the utility of conjugated polymers in active integrated optical devices. With an absorptance sensitivity of materials. We have used PDS to measure the optical absorption spectra of the conjugated polymers poly(1,4-phenylene-vinylene) (and derivitives) and polydiacetylene-4BCMU in the spectral region from 0.55 eV to 3 eV. Our spectra show that the shape of the absorption edge varies considerably from polymer to polymer, with polydiacetylene-4BCMU having the steepest absorption edge. The minimum absorption coefficients measured varied somewhat with sample age and quality, but were typically in the range 1 cm{sup {minus}1} to 10 cm{sup {minus}1}. In the region below 1 eV, overtones of C-H stretching modes were observed, indicating that further improvements in transparency in this spectral region might be achieved via deuteration of fluorination.
DENDRIMER CONJUGATES FOR SELECTIVE OF PROTEIN AGGREGATES
DEFF Research Database (Denmark)
2004-01-01
Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates are effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together...
Parallel synthesis and screening of peptide conjugates.
Dirksen, Anouk; Madsen, Mark; Dello Iacono, Giuseppe; Matin, Marla J; Bacica, Michael; Stanković, Nebojša; Callans, Sherri; Bhat, Abhijit
2014-06-18
Peptide conjugates represent an emerging class of therapeutics. However, in contrast to that of small molecules and peptides, the discovery and optimization of peptide conjugates is low in throughput, resource intensive, time-consuming, and based on educated decisions rather than screening. A strategy for the parallel synthesis and screening of peptide conjugates is presented that (1) reduces variability in the conjugation steps; (2) provides a new method to rapidly and quantitatively measure conversion in crude conjugation mixtures; (3) introduces a purification step using an immobilized chemical scavenger that does not rely on protein-specific binding; and (4) is supported by robust analytical methods to characterize the large number of end products. Copper-free click chemistry is used as the chemoselective ligation method for conjugation and purification. The productivity in the generation and screening of peptide conjugates is significantly improved by applying this strategy as is demonstrated by the optimization of the anti-Angiopoietin-2 (Ang2) CovX-body, CVX-060, a peptide-antibody scaffold conjugate that has advanced in clinical trials for oncology indications.
Catalytic enantioselective conjugate addition with Grignard reagents
Lopez, Fernando; Minnaard, Adriaan J.; Feringa, Ben L.
In this Account, recent advances in catalytic asymmetric conjugate addition of Grignard reagents are discussed. Synthetic methodology to perform highly enantioselective Cu-catalyzed conjugate addition of Grignard reagents to cyclic enones with ee's up to 96% was reported in 2004 from our
Tales of conjugation and sex pheromones
2011-01-01
This review covers highlights of the author's experience becoming and working as a plasmid biologist. The account chronicles a progression from studies of ColE1 DNA in Escherichia coli to Gram-positive bacteria with an emphasis on conjugation in enterococci. It deals with gene amplification, conjugative transposons and sex pheromones in the context of bacterial antibiotic resistance. PMID:22016844
Bio-Conjugates for Nanoscale Applications
DEFF Research Database (Denmark)
Villadsen, Klaus
Bio-conjugates for Nanoscale Applications is the title of this thesis, which covers three different projects in chemical bio-conjugation research, namely synthesis and applications of: Lipidated fluorescent peptides, carbohydrate oxime-azide linkers and N-aryl O-R2 oxyamine derivatives. Lipidated...
Preconditioning the modified conjugate gradient method ...
African Journals Online (AJOL)
In this paper, the convergence analysis of the conventional conjugate Gradient method was reviewed. And the convergence analysis of the modified conjugate Gradient method was analysed with our extension on preconditioning the algorithm. Convergence of the algorithm is a function of the condition number of M-1A.
Singularities and Conjugate Points in FLRW Spacetimes
Lam, Huibert het; Prokopec, Tom
2017-01-01
Conjugate points play an important role in the proofs of the singularity theorems of Hawking and Penrose. We examine the relation between singularities and conjugate points in FLRW spacetimes with a singularity. In particular we prove a theorem that when a non-comoving, non-spacelike geodesic in a
CONJUGATED BLOCK-COPOLYMERS FOR ELECTROLUMINESCENT DIODES
Hilberer, A; Gill, R.E; Herrema, J.K; Malliaras, G.G; Wildeman, J.; Hadziioannou, G
In this article we review results obtained in our laboratory on the design and study of new light-emitting polymers. We are interested in the synthesis and characterisation of block copolymers with regularly alternating conjugated and non conjugated sequences. The blocks giving rise to luminescence
The Conjugate Acid-Base Chart.
Treptow, Richard S.
1986-01-01
Discusses the difficulties that beginning chemistry students have in understanding acid-base chemistry. Describes the use of conjugate acid-base charts in helping students visualize the conjugate relationship. Addresses chart construction, metal ions, buffers and pH titrations, and the organic functional groups and nonaqueous solvents. (TW)
On discrete cosine transform | Zhou | Nigerian Journal of ...
African Journals Online (AJOL)
A new type of discrete cosine transform is proposed and its orthogonality is proved. Finally, we propose a generalized discrete W transform with three parameters, and prove its orthogonality for some new cases. Keywords: Discrete Fourier transform, discrete sine transform, discrete cosine transform, discrete W transform
Approximate error conjugation gradient minimization methods
Kallman, Jeffrey S
2013-05-21
In one embodiment, a method includes selecting a subset of rays from a set of all rays to use in an error calculation for a constrained conjugate gradient minimization problem, calculating an approximate error using the subset of rays, and calculating a minimum in a conjugate gradient direction based on the approximate error. In another embodiment, a system includes a processor for executing logic, logic for selecting a subset of rays from a set of all rays to use in an error calculation for a constrained conjugate gradient minimization problem, logic for calculating an approximate error using the subset of rays, and logic for calculating a minimum in a conjugate gradient direction based on the approximate error. In other embodiments, computer program products, methods, and systems are described capable of using approximate error in constrained conjugate gradient minimization problems.
Filtser, Omrit; Katz, Matthew J.
2015-01-01
We introduce the discrete Fr\\'echet gap and its variants as an alternative measure of similarity between polygonal curves. We believe that for some applications the new measure (and its variants) may better reflect our intuitive notion of similarity than the discrete Fr\\'echet distance (and its variants), since the latter measure is indifferent to (matched) pairs of points that are relatively close to each other. Referring to the frogs analogy by which the discrete Fr\\'echet distance is often...
International Nuclear Information System (INIS)
Yu, Z.G.; Smith, D.L.; Saxena, A.; Bishop, A.R.
1997-01-01
The electronic transmission across metal/conjugated-oligomer/metal structures in the presence of lattice fluctuations is studied for short oligomer chains. The lattice fluctuations are approximated by static white noise disorder. Resonant transmission occurs when the energy of an incoming electron coincides with a discrete electronic level of the oligomer. The corresponding transmission peak diminishes in intensity with increasing disorder strength. Because of disorder there is an enhancement of the electronic transmission for energies that lie within the electronic gap of the oligomer. If fluctuations are sufficiently strong, a transmission peak within the gap is found at the midgap energy E=0 for degenerate conjugated oligomers (e.g., trans-polyacetylene) and E≠0 for AB-type degenerate oligomers. These results can be interpreted in terms of soliton-antisoliton states created by lattice fluctuations. copyright 1997 The American Physical Society
Discrete calculus methods for counting
Mariconda, Carlo
2016-01-01
This book provides an introduction to combinatorics, finite calculus, formal series, recurrences, and approximations of sums. Readers will find not only coverage of the basic elements of the subjects but also deep insights into a range of less common topics rarely considered within a single book, such as counting with occupancy constraints, a clear distinction between algebraic and analytical properties of formal power series, an introduction to discrete dynamical systems with a thorough description of Sarkovskii’s theorem, symbolic calculus, and a complete description of the Euler-Maclaurin formulas and their applications. Although several books touch on one or more of these aspects, precious few cover all of them. The authors, both pure mathematicians, have attempted to develop methods that will allow the student to formulate a given problem in a precise mathematical framework. The aim is to equip readers with a sound strategy for classifying and solving problems by pursuing a mathematically rigorous yet ...
Quantum evolution by discrete measurements
International Nuclear Information System (INIS)
Roa, L; Guevara, M L Ladron de; Delgado, A; Olivares-RenterIa, G; Klimov, A B
2007-01-01
In this article we review two ways of driving a quantum system to a known pure state via a sequence discrete of von Neumann measurements. The first of them assumes that the initial state of the system is unknown, and the evolution is attained only with the help of two non-commuting observables. For this method, the overall success probability is maximized when the eigentstates of the involved observables constitute mutually unbiased bases. The second method assumes the initial state is known and it uses N observables which are consecutively measured to make the state of the system approach the target state. The probability of success of this procedure converges to 1 as the number of observables increases
Quantum evolution by discrete measurements
Energy Technology Data Exchange (ETDEWEB)
Roa, L [Center for Quantum Optics and Quantum Information, Departamento de Fisica, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile); Guevara, M L Ladron de [Departamento de Fisica, Universidad Catolica del Norte, Casilla 1280, Antofagasta (Chile); Delgado, A [Center for Quantum Optics and Quantum Information, Departamento de Fisica, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile); Olivares-RenterIa, G [Center for Quantum Optics and Quantum Information, Departamento de Fisica, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile); Klimov, A B [Departamento de Fisica, Universidad de Guadalajara, Revolucion 1500, 44420 Guadalajara, Jalisco (Mexico)
2007-10-15
In this article we review two ways of driving a quantum system to a known pure state via a sequence discrete of von Neumann measurements. The first of them assumes that the initial state of the system is unknown, and the evolution is attained only with the help of two non-commuting observables. For this method, the overall success probability is maximized when the eigentstates of the involved observables constitute mutually unbiased bases. The second method assumes the initial state is known and it uses N observables which are consecutively measured to make the state of the system approach the target state. The probability of success of this procedure converges to 1 as the number of observables increases.
Modeling discrete competitive facility location
Karakitsiou, Athanasia
2015-01-01
This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...
Multigrid methods for isogeometric discretization.
Gahalaut, K P S; Kraus, J K; Tomar, S K
2013-01-01
We present (geometric) multigrid methods for isogeometric discretization of scalar second order elliptic problems. The smoothing property of the relaxation method, and the approximation property of the intergrid transfer operators are analyzed. These properties, when used in the framework of classical multigrid theory, imply uniform convergence of two-grid and multigrid methods. Supporting numerical results are provided for the smoothing property, the approximation property, convergence factor and iterations count for V -, W - and F -cycles, and the linear dependence of V -cycle convergence on the smoothing steps. For two dimensions, numerical results include the problems with variable coefficients, simple multi-patch geometry, a quarter annulus, and the dependence of convergence behavior on refinement levels [Formula: see text], whereas for three dimensions, only the constant coefficient problem in a unit cube is considered. The numerical results are complete up to polynomial order [Formula: see text], and for [Formula: see text] and [Formula: see text] smoothness.
Discrete modelling of drapery systems
Thoeni, Klaus; Giacomini, Anna
2016-04-01
Drapery systems are an efficient and cost-effective measure in preventing and controlling rockfall hazards on rock slopes. The simplest form consists of a row of ground anchors along the top of the slope connected to a horizontal support cable from which a wire mesh is suspended down the face of the slope. Such systems are generally referred to as simple or unsecured draperies (Badger and Duffy 2012). Variations such as secured draperies, where a pattern of ground anchors is incorporated within the field of the mesh, and hybrid systems, where the upper part of an unsecured drapery is elevated to intercept rockfalls originating upslope of the installation, are becoming more and more popular. This work presents a discrete element framework for simulation of unsecured drapery systems and its variations. The numerical model is based on the classical discrete element method (DEM) and implemented into the open-source framework YADE (Šmilauer et al., 2010). The model takes all relevant interactions between block, drapery and slope into account (Thoeni et al., 2014) and was calibrated and validated based on full-scale experiments (Giacomini et al., 2012).The block is modelled as a rigid clump made of spherical particles which allows any shape to be approximated. The drapery is represented by a set of spherical particle with remote interactions. The behaviour of the remote interactions is governed by the constitutive behaviour of the wire and generally corresponds to a piecewise linear stress-strain relation (Thoeni et al., 2013). The same concept is used to model wire ropes. The rock slope is represented by rigid triangular elements where material properties (e.g., normal coefficient of restitution, friction angle) are assigned to each triangle. The capabilities of the developed model to simulate drapery systems and estimate the residual hazard involved with such systems is shown. References Badger, T.C., Duffy, J.D. (2012) Drapery systems. In: Turner, A.K., Schuster R
Discrete stochastic processes and applications
Collet, Jean-François
2018-01-01
This unique text for beginning graduate students gives a self-contained introduction to the mathematical properties of stochastics and presents their applications to Markov processes, coding theory, population dynamics, and search engine design. The book is ideal for a newly designed course in an introduction to probability and information theory. Prerequisites include working knowledge of linear algebra, calculus, and probability theory. The first part of the text focuses on the rigorous theory of Markov processes on countable spaces (Markov chains) and provides the basis to developing solid probabilistic intuition without the need for a course in measure theory. The approach taken is gradual beginning with the case of discrete time and moving on to that of continuous time. The second part of this text is more applied; its core introduces various uses of convexity in probability and presents a nice treatment of entropy.
Discrete symmetries with neutral mesons
Bernabéu, José
2018-01-01
Symmetries, and Symmetry Breakings, in the Laws of Physics play a crucial role in Fundamental Science. Parity and Charge Conjugation Violations prompted the consideration of Chiral Fields in the construction of the Standard Model, whereas CP-Violation needed at least three families of Quarks leading to Flavour Physics. In this Lecture I discuss the Conceptual Basis and the present experimental results for a Direct Evidence of Separate Reversal-in-Time T, CP and CPT Genuine Asymmetries in Decaying Particles like Neutral Meson Transitions, using Quantum Entanglement and the Decay as a Filtering Measurement. The eight transitions associated to the Flavour-CP eigenstate decay products of entangled neutral mesons have demonstrated with impressive significance a separate evidence of TRV and CPV in Bd-physics, whereas a CPTV asymmetry shows a 2σ effect interpreted as an upper limit. Novel CPTV observables are discussed for K physics at KLOE-2, including the difference between the semileptonic asymmetries from KL and KS, the ratios of double decay rate Intensities to Flavour-CP eigenstate decay products and the ω-effect. Their observation would lead to a change of paradigm beyond Quantum Field Theory, however there is nothing in Quantum Mechanics forbidding CPTV.
Tan, Lulu; Chen, Zhengbo; Zhao, Yan; Wei, Xiangcong; Li, Yonghui; Zhang, Chi; Wei, Xinling; Hu, Xiaochen
2016-11-15
We have presented an extensible, facile and sensitive multidimensional sensor based on DNA-gold nanoparticle (DNA-AuNP) conjugates for heavy metal ions (Ag(+), Hg(2+), Cr(3+), Sn(4+), Cd(2+), Cu(2+), Pb(2+), Zn(2+), and Mn(2+)) discrimination. In the presence of metal ions, the excluded effect of DNA and AuNPs with the same negative charges is disrupted, and the amount of FAM-labeled DNA adsorbed on AuNP surfaces increases, resulting in a more obvious fluorescence quenching effect. With the addition of NH2OH and HAuCl4, AuNPs grow into morphologically varied nanostructures (spherical to branched) depending on the resulting aptamer coverage, which gives rise to different colored solutions (reddish blush, purple and blue) observed by naked eyes. By simply changing the DNA sequences, three sensing elements can be easily obtained and added into this dual-channel multidimensional sensor. 9 heavy metal ions are distinguished by linear discriminant analysis (LDA) and primary component analysis (PCA). A highly sensitive discrimination of metal ion targets with the detection limit as low as 50nM with 100% identification accuracy is obtained. Remarkably, Cu(2+) and Hg(2+) ions with similar catalytic performance at various concentrations (300nM, 400nM, 500nM, respectively) and the mixture of the two metal ions with different volume ratios (total metal ion concentration: 500nM) can be successfully discriminated. In addition, nine heavy metal ions are also well-distinguished in river samples, and the accuracy of discrimination of these metal ions samples reaches 100%. Therefore, it will broaden the application field of DNA-AuNP conjugates-based multidimensional sensors. Copyright © 2016 Elsevier B.V. All rights reserved.
TAT peptide and its conjugates: proteolytic stability.
Grunwald, Jacob; Rejtar, Tomas; Sawant, Rupa; Wang, Zhouxi; Torchilin, Vladimir P
2009-08-19
The proteolytic cleavage of TATp, TATp-PEG(1000)-PE conjugate (TATp-conjugate), and TATp as TATp-conjugate in mixed micelles made of TATp-conjugate and PEG(5000)-PE (2.5% mol of TATp-conjugate, TATp-Mic) were studied by HPLC with fluorescent detection using fluorenylmethyl chloroformate (FMOC) labeling and by MALDI-TOF MS analysis. The cleavage kinetics were analyzed in human blood plasma and in trypsin-containing phosphate buffered saline (PBS), pH 7.4, to simulate the proteolytic activity of human plasma. The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer. The trypsinolysis followed pseudo-first-order kinetics. The cleavage of the free TATp was relatively fast with a half-life of a few minutes (t(1/2) ∼ 3.5 min). The TATp-conjugate showed more stability with about a 3-fold increase in half-life (t(1/2) ∼ 10 min). TATp in TATp-Mic was highly protected against proteolysis with an over 100-fold increase in half-life (t(1/2) ∼ 430 min). The shielding of TATp by PEG moieties in the proposed TATp-Mic is of great importance for its potential use as a cell-penetrating moiety for multifunctional "smart" drug delivery systems with detachable PEG.
Directory of Open Access Journals (Sweden)
Moskal P.
2016-01-01
Full Text Available Discrete symmetries such as parity (P, charge-conjugation (C and time reversal (T are of fundamental importance in physics and cosmology. Breaking of charge conjugation symmetry (C and its combination with parity (CP constitute necessary conditions for the existence of the asymmetry between matter and antimatter in the observed Universe. The presently known sources of discrete symmetries violations can account for only a tiny fraction of the excess of matter over antimatter. So far CP and T symmetries violations were observed only for systems involving quarks and they were never reported for the purely leptonic objects. In this article we describe briefly an experimental proposal for the test of discrete symmetries in the decays of positronium atom which is made exclusively of leptons. The experiments are conducted by means of the Jagiellonian Positron Emission Tomograph (J-PET which is constructed from strips of plastic scintillators enabling registration of photons from the positronium annihilation. J-PET tomograph together with the positronium target system enable to measure expectation values for the discrete symmetries odd operators constructed from (i spin vector of the ortho-positronium atom, (ii momentum vectors of photons originating from the decay of positronium, and (iii linear polarization direction of annihilation photons. Linearly polarized positronium will be produced in the highly porous aerogel or polymer targets, exploiting longitudinally polarized positrons emitted by the sodium 22Na isotope. Information about the polarization vector of orthopositronium will be available on the event by event basis and will be reconstructed from the known position of the positron source and the reconstructed position of the orthopositronium annihilation. In 2016 the first tests and calibration runs are planned, and the data collection with high statistics will commence in the year 2017.
DISCRETE ELEMENT MODELLING OF THE COMPRESSIVE ...
African Journals Online (AJOL)
Discrete element modelling is a numerical method capable of tracking the movement of individual objects within a bulk system and compute the resulting force and deformation as well as other parameters. The Discrete Element Method (DEM) has been used in this study to investigate the deformation of individual particles ...
Geometry and Hamiltonian mechanics on discrete spaces
Talasila, V.; Clemente-Gallardo, J.; Schaft, A.J. van der
2004-01-01
Numerical simulation is often crucial for analysing the behaviour of many complex systems which do not admit analytic solutions. To this end, one either converts a ‘smooth’ model into a discrete (in space and time) model, or models systems directly at a discrete level. The goal of this paper is to
Discrete/PWM Ballast-Resistor Controller
King, Roger J.
1994-01-01
Circuit offers low switching loss and automatic compensation for failure of ballast resistor. Discrete/PWM ballast-resistor controller improved shunt voltage-regulator circuit designed to supply power from high-resistance source to low-impedance bus. Provides both coarse discrete voltage levels (by switching of ballast resistors) and continuous fine control of voltage via pulse-width modulation.
Discrete Fourier analysis of multigrid algorithms
van der Vegt, Jacobus J.W.; Rhebergen, Sander
2011-01-01
The main topic of this report is a detailed discussion of the discrete Fourier multilevel analysis of multigrid algorithms. First, a brief overview of multigrid methods is given for discretizations of both linear and nonlinear partial differential equations. Special attention is given to the
Discretization vs. Rounding Error in Euler's Method
Borges, Carlos F.
2011-01-01
Euler's method for solving initial value problems is an excellent vehicle for observing the relationship between discretization error and rounding error in numerical computation. Reductions in stepsize, in order to decrease discretization error, necessarily increase the number of steps and so introduce additional rounding error. The problem is…
Geometry and Hamiltonian mechanics on discrete spaces
International Nuclear Information System (INIS)
Talasila, V; Clemente-Gallardo, J; Schaft, A J van der
2004-01-01
Numerical simulation is often crucial for analysing the behaviour of many complex systems which do not admit analytic solutions. To this end, one either converts a 'smooth' model into a discrete (in space and time) model, or models systems directly at a discrete level. The goal of this paper is to provide a discrete analogue of differential geometry, and to define on these discrete models a formal discrete Hamiltonian structure-in doing so we try to bring together various fundamental concepts from numerical analysis, differential geometry, algebraic geometry, simplicial homology and classical Hamiltonian mechanics. For example, the concept of a twisted derivation is borrowed from algebraic geometry for developing a discrete calculus. The theory is applied to a nonlinear pendulum and we compare the dynamics obtained through a discrete modelling approach with the dynamics obtained via the usual discretization procedures. Also an example of an energy-conserving algorithm on a simple harmonic oscillator is presented, and its effect on the Poisson structure is discussed
Discrete Riccati equation solutions: Distributed algorithms
Directory of Open Access Journals (Sweden)
D. G. Lainiotis
1996-01-01
Full Text Available In this paper new distributed algorithms for the solution of the discrete Riccati equation are introduced. The algorithms are used to provide robust and computational efficient solutions to the discrete Riccati equation. The proposed distributed algorithms are theoretically interesting and computationally attractive.
Cuspidal discrete series for semisimple symmetric spaces
DEFF Research Database (Denmark)
Andersen, Nils Byrial; Flensted-Jensen, Mogens; Schlichtkrull, Henrik
2012-01-01
We propose a notion of cusp forms on semisimple symmetric spaces. We then study the real hyperbolic spaces in detail, and show that there exists both cuspidal and non-cuspidal discrete series. In particular, we show that all the spherical discrete series are non-cuspidal. (C) 2012 Elsevier Inc. All...
Current Density and Continuity in Discretized Models
Boykin, Timothy B.; Luisier, Mathieu; Klimeck, Gerhard
2010-01-01
Discrete approaches have long been used in numerical modelling of physical systems in both research and teaching. Discrete versions of the Schrodinger equation employing either one or several basis functions per mesh point are often used by senior undergraduates and beginning graduate students in computational physics projects. In studying…
Variance Swap Replication: Discrete or Continuous?
Directory of Open Access Journals (Sweden)
Fabien Le Floc’h
2018-02-01
Full Text Available The popular replication formula to price variance swaps assumes continuity of traded option strikes. In practice, however, there is only a discrete set of option strikes traded on the market. We present here different discrete replication strategies and explain why the continuous replication price is more relevant.
Geometry and Hamiltonian mechanics on discrete spaces
Talasila, V.; Clemente Gallardo, J.J.; Clemente-Gallardo, J.; van der Schaft, Arjan
2004-01-01
Numerical simulation is often crucial for analysing the behaviour of many complex systems which do not admit analytic solutions. To this end, one either converts a 'smooth' model into a discrete (in space and time) model, or models systems directly at a discrete level. The goal of this paper is to
Handbook on modelling for discrete optimization
Pitsoulis, Leonidas; Williams, H
2006-01-01
The primary objective underlying the Handbook on Modelling for Discrete Optimization is to demonstrate and detail the pervasive nature of Discrete Optimization. While its applications cut across an incredibly wide range of activities, many of the applications are only known to specialists. It is the aim of this handbook to correct this. It has long been recognized that "modelling" is a critically important mathematical activity in designing algorithms for solving these discrete optimization problems. Nevertheless solving the resultant models is also often far from straightforward. In recent years it has become possible to solve many large-scale discrete optimization problems. However, some problems remain a challenge, even though advances in mathematical methods, hardware, and software technology have pushed the frontiers forward. This handbook couples the difficult, critical-thinking aspects of mathematical modeling with the hot area of discrete optimization. It will be done in an academic handbook treatment...
Conjugated Polymers and Oligomers: Structural and Soft Matter Aspects
DEFF Research Database (Denmark)
conjugated polymer backbone, water soluble conjugated polyelectrolytes and surfactants, conjugated molecules and biomolecules and DNA and the advanced use of synchrotron radiation and electron microscopy to find out structural details in conjugated molecule films and devices as well as under ambient...
Discrete frequency slice wavelet transform
Yan, Zhonghong; Tao, Ting; Jiang, Zhongwei; Wang, Haibin
2017-11-01
This paper introduces a new kind of Time-Frequency Representation (TFR) method called Discrete Frequency Slice Wavelet Transform (DFSWT). It is an improved version of Frequency Slice Wavelet Transform (FSWT). The previous researches on FSWT show that it is a new efficient TFR in an easy way without strict limitation as traditional wavelet theory. DFSWT as well as FSWT are defined directly in frequency domain, and still keep its properties in time-frequency domain as FSWT decomposition, reconstruction and filter design, etc. However, the original signal is decomposed and reconstructed on a Chosen Frequency Domains (CFD) as need of application. CFD means that the decomposition and reconstruction are not completed on all frequency components. At first, it is important to discuss the necessary condition of CFD to reconstruct the original signal. And then based on norm l2, an optimization algorithm is introduced to reconstruct the original signal even accurately. Finally, for a test example, the TFR analysis of a real life signal is shown. Some conclusions are drawn that the concept of CFD is very useful to application, and the DFSWT can become a simple and easy tool of TFR method, and also provide a new idea of low speed sampling of high frequency signal in applications.
Succinct Sampling from Discrete Distributions
DEFF Research Database (Denmark)
Bringmann, Karl; Larsen, Kasper Green
2013-01-01
We revisit the classic problem of sampling from a discrete distribution: Given n non-negative w-bit integers x_1,...,x_n, the task is to build a data structure that allows sampling i with probability proportional to x_i. The classic solution is Walker's alias method that takes, when implemented...... on a Word RAM, O(n) preprocessing time, O(1) expected query time for one sample, and n(w+2 lg n+o(1)) bits of space. Using the terminology of succinct data structures, this solution has redundancy 2n lg n+o(n) bits, i.e., it uses 2n lg n+o(n) bits in addition to the information theoretic minimum required...... requirement of the classic solution for a fundamental sampling problem, on the other hand, they provide the strongest known separation between the systematic and non-systematic case for any data structure problem. Finally, we also believe our upper bounds are practically efficient and simpler than Walker...
Oligonucleotides conjugated to short lysine chains.
Winkler, Johannes; Urban, Ernst; Noe, Christian R
2005-01-01
A new method for synthesizing oligonucleotide peptide conjugates by an in-line approach is presented. A phosphorothioate oligonucleotide with the sequence of bcl-2 targeted Oblimersen by employing a modified 2'-amino-2'-desoxy-uridine nucleotide bearing a succinyl linker at the 2' position was prepared. The carboxyl group was protected for solid-phase synthesis as the benzyl ester. Ester cleavage was afforded by a phase transfer reaction using palladium nanoparticles as catalyst and cyclohexadiene as hydrogen donor. Short tails of up to three lysyl residues were conjugated to the oligonucleotide by an inverse stepwise peptide synthesis. The conjugates were characterized by HPLC, mass spectrometry, and circular dichroism. Influence of lysyl tails on CD spectra were minimal. Melting profiles revealed only minimal destabilizing effects on duplexes by conjugation of peptides.
Stochastic differential equations used to model conjugation
DEFF Research Database (Denmark)
Philipsen, Kirsten Riber; Christiansen, Lasse Engbo
be split into measurement noise and system noise. The system noise is used to compensate for those biological processes not explicitly described by the model. Many authors model conjugation by a simple mass action model first proposed by Levin et al. (1979). Also Michaelis-Menten dependence...... by an experiment conducted with E. faecium. In addition, we suggest that a 3rd order time-delay must be included in the model to account for the delay before a newly conjugated plasmid is expressed. A ML estimate of the parameters based on experimental data is found using the software CTSM. The conjugation rate......Stochastic differential equations (SDEs) are used to model horizontal transfer of antibiotic resis- tance by conjugation. The model describes the concentration of donor, recipient, transconjugants and substrate. The strength of the SDE model over the traditional ODE models is that the noise can...
Deciphering conjugative plasmid permissiveness in wastewater microbiomes
DEFF Research Database (Denmark)
Jacquiod, Samuel Jehan Auguste; Brejnrod, Asker Daniel; Milani, Stefan Morberg
2017-01-01
Wastewater treatment plants (WWTPs) are designed to robustly treat polluted water. They are characterized by ceaseless flows of organic, chemical and microbial matter, followed by treatment steps before environmental release. WWTPs are hotspots of horizontal gene transfer between bacteria via...... conjugative plasmids, leading to dissemination of potentially hazardous genetic material such as antimicrobial resistance genes (AMRGs). While current focus is on the threat of AMRGs spreading and their environmental maintenance, conjugative plasmid transfer dynamics within and between bacterial communities...... still remains largely uncharted. Furthermore, current in vitro methods used to assess conjugation in complex microbiomes do not include in situ behaviours of recipient cells, resulting in partial understanding of transfers. We investigated the in vitro conjugation capacities of WWTP microbiomes from...
Design and Application of Antimicrobial Peptide Conjugates
Directory of Open Access Journals (Sweden)
Andre Reinhardt
2016-05-01
Full Text Available Antimicrobial peptides (AMPs are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. Within this article, recent work on AMP conjugates is reviewed. Different aspects will be highlighted as a combination of AMPs with antibiotics or organometallic compounds aiming to increase antibacterial activity or target selectivity, conjugation with photosensitizers for improving photodynamic therapy (PDT or the attachment to particles, to name only a few. Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry.
Lattice Boltzmann formulation for conjugate heat transfer in heterogeneous media.
Karani, Hamid; Huber, Christian
2015-02-01
In this paper, we propose an approach for studying conjugate heat transfer using the lattice Boltzmann method (LBM). The approach is based on reformulating the lattice Boltzmann equation for solving the conservative form of the energy equation. This leads to the appearance of a source term, which introduces the jump conditions at the interface between two phases or components with different thermal properties. The proposed source term formulation conserves conductive and advective heat flux simultaneously, which makes it suitable for modeling conjugate heat transfer in general multiphase or multicomponent systems. The simple implementation of the source term approach avoids any correction of distribution functions neighboring the interface and provides an algorithm that is independent from the topology of the interface. Moreover, our approach is independent of the choice of lattice discretization and can be easily applied to different advection-diffusion LBM solvers. The model is tested against several benchmark problems including steady-state convection-diffusion within two fluid layers with parallel and normal interfaces with respect to the flow direction, unsteady conduction in a three-layer stratified domain, and steady conduction in a two-layer annulus. The LBM results are in excellent agreement with analytical solution. Error analysis shows that our model is first-order accurate in space, but an extension to a second-order scheme is straightforward. We apply our LBM model to heat transfer in a two-component heterogeneous medium with a random microstructure. This example highlights that the method we propose is independent of the topology of interfaces between the different phases and, as such, is ideally suited for complex natural heterogeneous media. We further validate the present LBM formulation with a study of natural convection in a porous enclosure. The results confirm the reliability of the model in simulating complex coupled fluid and thermal dynamics
Energetic Tuning in Spirocyclic Conjugated Polymers
Hugo Bronstein; Frank D. King
2016-01-01
Precise control of the energy levels in a conjugated polymer is the key to allowing their exploitation in optoelectronic devices. The introduction of spirocycles into conjugated polymers has traditionally been used to enhance their solid state microstructure. Here we present a highly novel method of energetic tuning through the use of electronically active spirocyclic systems. By modifying the size and oxidation state of a heteroatom in an orthogonal spirocycle we demonstrate energetic fine t...
Two-zone double phase conjugate mirror
Belić, M. R.; Vujić, D.; Sandfuchs, O.; Kaiser, F.
2001-10-01
An analysis of photorefractive (PR) oscillators consisting of two facing four-wave mixing regions is carried out. The threshold and operation conditions of different phase conjugate mirrors are discussed with the help of the grating action method. In particular, the threshold and the operation of the two-zone double phase conjugate mirror (DPCM) is compared with other related PR oscillators, the interconnected ring, and different connected DPCM.
Rapid modification of retroviruses using lipid conjugates
International Nuclear Information System (INIS)
Mukherjee, Nimisha G; Le Doux, Joseph M; Andrew Lyon, L
2009-01-01
Methods are needed to manipulate natural nanoparticles. Viruses are particularly interesting because they can act as therapeutic cellular delivery agents. Here we examine a new method for rapidly modifying retroviruses that uses lipid conjugates composed of a lipid anchor (1,2-distearoyl-sn-glycero-3-phosphoethanolamine), a polyethylene glycol chain, and biotin. The conjugates rapidly and stably modified retroviruses and enabled them to bind streptavidin. The implication of this work for modifying viruses for gene therapy and vaccination protocols is discussed.
Syntheses of conjugated polymers for photonics
Czech Academy of Sciences Publication Activity Database
Výprachtický, Drahomír; Cimrová, Věra; Kmínek, Ivan; Pavlačková, Petra
2010-01-01
Roč. 295, č. 1 (2010), s. 94-99 ISSN 1022-1360. [Prague Meetings on Macromolecules /73./ New Frontiers in Macromolecular Science: From Macromolecular Concepts of Living Matter to Polymers for Better Quality of Life. Prague, 05.07.2009-09.07.2009] R&D Projects: GA MŠk(CZ) 1M06031 Institutional research plan: CEZ:AV0Z40500505 Keywords : cis and trans isomers * conjugated polymer * conjugated polyelectrolyte Subject RIV: BM - Solid Matter Physics ; Magnetism
Zhong, Ruibo; Yuan, Ming; Gao, Haiyang; Bai, Zhijun; Guo, Jun; Zhao, Xinmin; Zhang, Feng
2016-03-01
Discrete biomolecule-nanoparticle (NP) conjugates play paramount roles in nanofabrication, in which the key is to get the precise molar extinction coefficient of NPs. By making best use of the gift from a specific separation phenomenon of agarose gel electrophoresis (GE), amphiphilic polymer coated NP with exact number of bovine serum albumin (BSA) proteins can be extracted and further experimentally employed to precisely calculate the molar extinction coefficient of the NPs. This method could further benefit the evaluation and extraction of any other dual-component NP-containing bio-conjugates.
Compatible Spatial Discretizations for Partial Differential Equations
Energy Technology Data Exchange (ETDEWEB)
Arnold, Douglas, N, ed.
2004-11-25
From May 11--15, 2004, the Institute for Mathematics and its Applications held a hot topics workshop on Compatible Spatial Discretizations for Partial Differential Equations. The numerical solution of partial differential equations (PDE) is a fundamental task in science and engineering. The goal of the workshop was to bring together a spectrum of scientists at the forefront of the research in the numerical solution of PDEs to discuss compatible spatial discretizations. We define compatible spatial discretizations as those that inherit or mimic fundamental properties of the PDE such as topology, conservation, symmetries, and positivity structures and maximum principles. A wide variety of discretization methods applied across a wide range of scientific and engineering applications have been designed to or found to inherit or mimic intrinsic spatial structure and reproduce fundamental properties of the solution of the continuous PDE model at the finite dimensional level. A profusion of such methods and concepts relevant to understanding them have been developed and explored: mixed finite element methods, mimetic finite differences, support operator methods, control volume methods, discrete differential forms, Whitney forms, conservative differencing, discrete Hodge operators, discrete Helmholtz decomposition, finite integration techniques, staggered grid and dual grid methods, etc. This workshop seeks to foster communication among the diverse groups of researchers designing, applying, and studying such methods as well as researchers involved in practical solution of large scale problems that may benefit from advancements in such discretizations; to help elucidate the relations between the different methods and concepts; and to generally advance our understanding in the area of compatible spatial discretization methods for PDE. Particular points of emphasis included: + Identification of intrinsic properties of PDE models that are critical for the fidelity of numerical
Conjugation in Gram-Positive Bacteria.
Goessweiner-Mohr, Nikolaus; Arends, Karsten; Keller, Walter; Grohmann, Elisabeth
2014-08-01
Conjugative transfer is the most important means of spreading antibiotic resistance and virulence factors among bacteria. The key vehicles of this horizontal gene transfer are a group of mobile genetic elements, termed conjugative plasmids. Conjugative plasmids contain as minimum instrumentation an origin of transfer (oriT), DNA-processing factors (a relaxase and accessory proteins), as well as proteins that constitute the trans-envelope transport channel, the so-called mating pair formation (Mpf) proteins. All these protein factors are encoded by one or more transfer (tra) operons that together form the DNA transport machinery, the Gram-positive type IV secretion system. However, multicellular Gram-positive bacteria belonging to the streptomycetes appear to have evolved another mechanism for conjugative plasmid spread reminiscent of the machinery involved in bacterial cell division and sporulation, which transports double-stranded DNA from donor to recipient cells. Here, we focus on the protein key players involved in the plasmid spread through the two different modes and present a new secondary structure homology-based classification system for type IV secretion protein families. Moreover, we discuss the relevance of conjugative plasmid transfer in the environment and summarize novel techniques to visualize and quantify conjugative transfer in situ.
On the definition of discrete hydrodynamic variables
Español, Pep; Zúñiga, Ignacio
2009-10-01
The Green-Kubo formula for discrete hydrodynamic variables involves information about not only the fluid transport coefficients but also about discrete versions of the differential operators that govern the evolution of the discrete variables. This gives an intimate connection between discretization procedures in fluid dynamics and coarse-graining procedures used to obtain hydrodynamic behavior of molecular fluids. We observed that a natural definition of discrete hydrodynamic variables in terms of Voronoi cells leads to a Green-Kubo formula which is divergent, rendering the full coarse-graining strategy useless. In order to understand this subtle issue, in the present paper we consider the coarse graining of noninteracting Brownian particles. The discrete hydrodynamic variable for this problem is the number of particles within Voronoi cells. Thanks to the simplicity of the model we spot the origin of the singular behavior of the correlation functions. We offer an alternative definition, based on the concept of a Delaunay cell that behaves properly, suggesting the use of the Delaunay construction for the coarse graining of molecular fluids at the discrete hydrodynamic level.
Higher dimensional discrete Cheeger inequalities
Directory of Open Access Journals (Sweden)
Anna Gundert
2015-01-01
Full Text Available For graphs there exists a strong connection between spectral and combinatorial expansion properties. This is expressed, e.g., by the discrete Cheeger inequality, the lower bound of which states that $\\lambda(G \\leq h(G$, where $\\lambda(G$ is the second smallest eigenvalue of the Laplacian of a graph $G$ and $h(G$ is the Cheeger constant measuring the edge expansion of $G$. We are interested in generalizations of expansion properties to finite simplicial complexes of higher dimension (or uniform hypergraphs. Whereas higher dimensional Laplacians were introduced already in 1945 by Eckmann, the generalization of edge expansion to simplicial complexes is not straightforward. Recently, a topologically motivated notion analogous to edge expansion that is based on $\\mathbb{Z}_2$-cohomology was introduced by Gromov and independently by Linial, Meshulam and Wallach. It is known that for this generalization there is no direct higher dimensional analogue of the lower bound of the Cheeger inequality. A different, combinatorially motivated generalization of the Cheeger constant, denoted by $h(X$, was studied by Parzanchevski, Rosenthal and Tessler. They showed that indeed $\\lambda(X \\leq h(X$, where $\\lambda(X$ is the smallest non-trivial eigenvalue of the ($(k-1$-dimensional upper Laplacian, for the case of $k$-dimensional simplicial complexes $X$ with complete $(k-1$-skeleton. Whether this inequality also holds for $k$-dimensional complexes with non-com\\-plete$(k-1$-skeleton has been an open question.We give two proofs of the inequality for arbitrary complexes. The proofs differ strongly in the methods and structures employed,and each allows for a different kind of additional strengthening of the original result.
Refined isogeometric analysis for a preconditioned conjugate gradient solver
Garcia, Daniel
2018-02-12
Starting from a highly continuous Isogeometric Analysis (IGA) discretization, refined Isogeometric Analysis (rIGA) introduces C0 hyperplanes that act as separators for the direct LU factorization solver. As a result, the total computational cost required to solve the corresponding system of equations using a direct LU factorization solver dramatically reduces (up to a factor of 55) Garcia et al. (2017). At the same time, rIGA enriches the IGA spaces, thus improving the best approximation error. In this work, we extend the complexity analysis of rIGA to the case of iterative solvers. We build an iterative solver as follows: we first construct the Schur complements using a direct solver over small subdomains (macro-elements). We then assemble those Schur complements into a global skeleton system. Subsequently, we solve this system iteratively using Conjugate Gradients (CG) with an incomplete LU (ILU) preconditioner. For a 2D Poisson model problem with a structured mesh and a uniform polynomial degree of approximation, rIGA achieves moderate savings with respect to IGA in terms of the number of Floating Point Operations (FLOPs) and computational time (in seconds) required to solve the resulting system of linear equations. For instance, for a mesh with four million elements and polynomial degree p=3, the iterative solver is approximately 2.6 times faster (in time) when applied to the rIGA system than to the IGA one. These savings occur because the skeleton rIGA system contains fewer non-zero entries than the IGA one. The opposite situation occurs for 3D problems, and as a result, 3D rIGA discretizations provide no gains with respect to their IGA counterparts when considering iterative solvers.
Thermodynamics of discrete-charge quantum circuits
Energy Technology Data Exchange (ETDEWEB)
Utreras-Díaz, C.A., E-mail: cutreras@uach.cl [Instituto de Ciencias Físicas y Matemáticas, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja s/n, Casilla 567, Valdivia (Chile); Laroze, D., E-mail: dlarozen@uta.cl [Instituto de Alta Investigación, Universidad de Tarapacá, Casilla 7D, Arica (Chile); SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)
2015-11-01
We study a dilute gas made of quantum circuits with discrete charge, interacting with a thermal reservoir at absolute temperature T, using Boltzmann statistics. This system is described by a quantum Hamiltonian that explicitly includes the effect of the discrete nature of the electric charge within a circuit approach. The eigenfunctions can be expressed as solutions of the Mathieu equation, and the energy spectrum is related to its characteristic values. We also make a comparative numerical study of the thermal properties, between the quantum case with discrete charge, and the so-called semiclassical approximation.
Discrete Flavour Symmetries from the Heisenberg Group
Floratos, E.G.
2016-01-01
Non-abelian discrete symmetries are of particular importance in model building. They are mainly invoked to explain the various fermion mass hierarchies and forbid dangerous superpotential terms. In string models they are usually associated to the geometry of the compactification manifold and more particularly to the magnetised branes in toroidal compactifications. Motivated by these facts, in this note we propose a unified framework to construct representations of finite discrete family groups based on the automorphisms of the discrete and finite Heisenberg group. We focus in particular in the $PSL_2(p)$ groups which contain the phenomenologically interesting cases.
Discrete-Time Biomedical Signal Encryption
Directory of Open Access Journals (Sweden)
Victor Grigoraş
2017-12-01
Full Text Available Chaotic modulation is a strong method of improving communication security. Analog and discrete chaotic systems are presented in actual literature. Due to the expansion of digital communication, discrete-time systems become more efficient and closer to actual technology. The present contribution offers an in-depth analysis of the effects chaos encryption produce on 1D and 2D biomedical signals. The performed simulations show that modulating signals are precisely recovered by the synchronizing receiver if discrete systems are digitally implemented and the coefficients precisely correspond. Channel noise is also applied and its effects on biomedical signal demodulation are highlighted.
Ensemble simulations with discrete classical dynamics
DEFF Research Database (Denmark)
Toxværd, Søren
2013-01-01
{E}(h)$ is employed to determine the relation with the corresponding energy, $E$ for the analytic dynamics with $h=0$ and the zero-order estimate $E_0(h)$ of the energy for discrete dynamics, appearing in the literature for MD with VA. We derive a corresponding time reversible VA algorithm for canonical dynamics......For discrete classical Molecular dynamics (MD) obtained by the "Verlet" algorithm (VA) with the time increment $h$ there exist a shadow Hamiltonian $\\tilde{H}$ with energy $\\tilde{E}(h)$, for which the discrete particle positions lie on the analytic trajectories for $\\tilde{H}$. $\\tilde...
Discrete Tomography and Imaging of Polycrystalline Structures
DEFF Research Database (Denmark)
Alpers, Andreas
Laboratory for Sustainable Energy), for instance, we study polycrystalline materials via synchrotron X-ray diffraction. Several reconstruction problems arise, most of them exhibit inherently discrete aspects. In this talk I want to give a concise mathematical introduction to some of these reconstruction...... problems. Special focus is on their relationship to classical discrete tomography. Several open mathematical questions will be mentioned along the way.......High resolution transmission electron microscopy is commonly considered as the standard application for discrete tomography. While this has yet to be technically realized, new applications with a similar flavor have emerged in materials science. In our group at Ris� DTU (Denmark's National...
Hairs of discrete symmetries and gravity
Directory of Open Access Journals (Sweden)
Kang Sin Choi
2017-06-01
Full Text Available Gauge symmetries are known to be respected by gravity because gauge charges carry flux lines, but global charges do not carry flux lines and are not conserved by gravitational interaction. For discrete symmetries, they are spontaneously broken in the Universe, forming domain walls. Since the realization of discrete symmetries in the Universe must involve the vacuum expectation values of Higgs fields, a string-like configuration (hair at the intersection of domain walls in the Higgs vacua can be realized. Therefore, we argue that discrete charges are also respected by gravity.
Hairs of discrete symmetries and gravity
Energy Technology Data Exchange (ETDEWEB)
Choi, Kang Sin [Scranton Honors Program, Ewha Womans University, Seodaemun-Gu, Seoul 03760 (Korea, Republic of); Center for Fields, Gravity and Strings, CTPU, Institute for Basic Sciences, Yuseong-Gu, Daejeon 34047 (Korea, Republic of); Kim, Jihn E., E-mail: jihnekim@gmail.com [Department of Physics, Kyung Hee University, 26 Gyungheedaero, Dongdaemun-Gu, Seoul 02447 (Korea, Republic of); Center for Axion and Precision Physics Research (IBS), 291 Daehakro, Yuseong-Gu, Daejeon 34141 (Korea, Republic of); Kyae, Bumseok [Department of Physics, Pusan National University, 2 Busandaehakro-63-Gil, Geumjeong-Gu, Busan 46241 (Korea, Republic of); Nam, Soonkeon [Department of Physics, Kyung Hee University, 26 Gyungheedaero, Dongdaemun-Gu, Seoul 02447 (Korea, Republic of)
2017-06-10
Gauge symmetries are known to be respected by gravity because gauge charges carry flux lines, but global charges do not carry flux lines and are not conserved by gravitational interaction. For discrete symmetries, they are spontaneously broken in the Universe, forming domain walls. Since the realization of discrete symmetries in the Universe must involve the vacuum expectation values of Higgs fields, a string-like configuration (hair) at the intersection of domain walls in the Higgs vacua can be realized. Therefore, we argue that discrete charges are also respected by gravity.
Parallel discrete ordinates methods in the SCEPTRE project
International Nuclear Information System (INIS)
Pautz, S.; Bohnhoff, B.; Drumm, C.; Fan, W.
2009-01-01
Although the transport of photons and electrons/positrons can be described by the same Boltzmann transport equation, the cross sections are very different, resulting in very different iterative convergence properties for the two particle types. The SCEPTRE project contains a suite of deterministic codes for solving the linear steady-state Boltzmann transport equation, including two very different solution algorithms: a sweeps-based approach for solving the first-order transport equation that is efficient for photon transport, and a conjugate-gradient algorithm for solving the second-order transport equation that is efficient for electron/positron transport. These two solution algorithms are coupled through a common set of interfaces to handle the finite element approximation in space, the discrete-ordinates method in angle, the scattering source terms, input parsing, pre- and post-processing capabilities. We evaluate the two solution algorithms by comparing the run times for photon- and electron-transport problems, investigating parallel performance and effects from finite-element basis function types, preconditioning, and scaling with angular quadrature order and Legendre cross section expansion order. (authors)
Bayesian inference from count data using discrete uniform priors.
Directory of Open Access Journals (Sweden)
Federico Comoglio
Full Text Available We consider a set of sample counts obtained by sampling arbitrary fractions of a finite volume containing an homogeneously dispersed population of identical objects. We report a Bayesian derivation of the posterior probability distribution of the population size using a binomial likelihood and non-conjugate, discrete uniform priors under sampling with or without replacement. Our derivation yields a computationally feasible formula that can prove useful in a variety of statistical problems involving absolute quantification under uncertainty. We implemented our algorithm in the R package dupiR and compared it with a previously proposed Bayesian method based on a Gamma prior. As a showcase, we demonstrate that our inference framework can be used to estimate bacterial survival curves from measurements characterized by extremely low or zero counts and rather high sampling fractions. All in all, we provide a versatile, general purpose algorithm to infer population sizes from count data, which can find application in a broad spectrum of biological and physical problems.
Comparing the Discrete and Continuous Logistic Models
Gordon, Sheldon P.
2008-01-01
The solutions of the discrete logistic growth model based on a difference equation and the continuous logistic growth model based on a differential equation are compared and contrasted. The investigation is conducted using a dynamic interactive spreadsheet. (Contains 5 figures.)
Can time be a discrete dynamical variable
International Nuclear Information System (INIS)
Lee, T.D.
1983-01-01
The possibility that time can be regarded as a discrete dynamical variable is examined through all phases of mechanics: from classical mechanics to nonrelativistic quantum mechanics, and to relativistic quantum field theories. (orig.)
Breatherlike impurity modes in discrete nonlinear lattices
DEFF Research Database (Denmark)
Hennig, D.; Rasmussen, Kim; Tsironis, G. P.
1995-01-01
We investigate the properties of a disordered generalized discrete nonlinear Schrodinger equation, containing both diagonal and nondiagonal nonlinear terms. The equation models a Linear host lattice doped with nonlinear impurities. We find different types of impurity states that form itinerant...
Confining and Structuring Discretion: Discretionary Justice
Davis, Kenneth Culp
1971-01-01
Locate the injustice in our entire government and legal system in order to best improve the quality of justice to individuals where decisions are made by discretion and not by rule or principles. (Editor/IR)
Running Parallel Discrete Event Simulators on Sierra
Energy Technology Data Exchange (ETDEWEB)
Barnes, P. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jefferson, D. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
2015-12-03
In this proposal we consider porting the ROSS/Charm++ simulator and the discrete event models that run under its control so that they run on the Sierra architecture and make efficient use of the Volta GPUs.
Quotient of manifolds by discrete groups
International Nuclear Information System (INIS)
Ardalan, F.; Arfaei, H.
1985-09-01
Quotient of manifolds by discrete subgroups of their isometry group are considered. In particular, symmetry breaking due to the quotient structure, topological properties and harmonic analysis of the resultant manifolds are discussed and illustrated by two dimensional examples. (author)
Memorized discrete systems and time-delay
Luo, Albert C J
2017-01-01
This book examines discrete dynamical systems with memory—nonlinear systems that exist extensively in biological organisms and financial and economic organizations, and time-delay systems that can be discretized into the memorized, discrete dynamical systems. It book further discusses stability and bifurcations of time-delay dynamical systems that can be investigated through memorized dynamical systems as well as bifurcations of memorized nonlinear dynamical systems, discretization methods of time-delay systems, and periodic motions to chaos in nonlinear time-delay systems. The book helps readers find analytical solutions of MDS, change traditional perturbation analysis in time-delay systems, detect motion complexity and singularity in MDS; and determine stability, bifurcation, and chaos in any time-delay system.
On organizing principles of discrete differential geometry. Geometry of spheres
International Nuclear Information System (INIS)
Bobenko, Alexander I; Suris, Yury B
2007-01-01
Discrete differential geometry aims to develop discrete equivalents of the geometric notions and methods of classical differential geometry. This survey contains a discussion of the following two fundamental discretization principles: the transformation group principle (smooth geometric objects and their discretizations are invariant with respect to the same transformation group) and the consistency principle (discretizations of smooth parametrized geometries can be extended to multidimensional consistent nets). The main concrete geometric problem treated here is discretization of curvature-line parametrized surfaces in Lie geometry. Systematic use of the discretization principles leads to a discretization of curvature-line parametrization which unifies circular and conical nets.
Definable maximal discrete sets in forcing extensions
DEFF Research Database (Denmark)
Törnquist, Asger Dag; Schrittesser, David
2018-01-01
Let be a Σ11 binary relation, and recall that a set A is -discrete if no two elements of A are related by . We show that in the Sacks and Miller forcing extensions of L there is a Δ12 maximal -discrete set. We use this to answer in the negative the main question posed in [5] by showing...
Nonlinear integrodifferential equations as discrete systems
Tamizhmani, K. M.; Satsuma, J.; Grammaticos, B.; Ramani, A.
1999-06-01
We analyse a class of integrodifferential equations of the `intermediate long wave' (ILW) type. We show that these equations can be formally interpreted as discrete, differential-difference systems. This allows us to link equations of this type with previous results of ours involving differential-delay equations and, on the basis of this, propose new integrable equations of ILW type. Finally, we extend this approach to pure difference equations and propose ILW forms for the discrete lattice KdV equation.
't Hooft anomaly matching for discrete symmetries
International Nuclear Information System (INIS)
Csaki, C.; Murayama, Hitoshi; Lawrence Berkeley National Lab., CA
1998-05-01
The authors show how to extend the 't Hooft anomaly matching conditions to discrete symmetries. They check these discrete anomally matching conditions on several proposed low-energy spectra of certain strongly interacting gauge theories. The excluded examples include the proposed chirally symmetric vacuum of pure N = 1 supersymmetric yang-Mills theories, certain non-supersymmetric confining theories and some self-dual N = 1 supersymmetric theories based on exceptional groups
Quadratic Term Structure Models in Discrete Time
Marco Realdon
2006-01-01
This paper extends the results on quadratic term structure models in continuos time to the discrete time setting. The continuos time setting can be seen as a special case of the discrete time one. Recursive closed form solutions for zero coupon bonds are provided even in the presence of multiple correlated underlying factors. Pricing bond options requires simple integration. Model parameters may well be time dependent without scuppering such tractability. Model estimation does not require a r...
Discrete symmetries and solar neutrino mixing
Energy Technology Data Exchange (ETDEWEB)
Kapetanakis, D.; Mayr, P.; Nilles, H.P. (Physik Dept., Technische Univ. Muenchen, Garching (Germany) Max-Planck-Inst. fuer Physik, Werner-Heisenberg-Inst., Muenchen (Germany))
1992-05-21
We study the question of resonant solar neutrino mixing in the framework of the supersymmetric extension of the standard model. Discrete symmetries that are consistent with solar neutrino mixing and proton stability are classified. In the minimal model they are shown to lead to two distinct patterns of allowed dimension-four operators. Imposing anomaly freedom, only three different discrete Z{sub N}-symmetries (with N=2, 3, 6) are found to be phenomenologically acceptable. (orig.).
Discrete symmetries and solar neutrino mixing
International Nuclear Information System (INIS)
Kapetanakis, D.; Mayr, P.; Nilles, H.P.
1992-01-01
We study the question of resonant solar neutrino mixing in the framework of the supersymmetric extension of the standard model. Discrete symmetries that are consistent with solar neutrino mixing and proton stability are classified. In the minimal model they are shown to lead to two distinct patterns of allowed dimension-four operators. Imposing anomaly freedom, only three different discrete Z N -symmetries (with N=2, 3, 6) are found to be phenomenologically acceptable. (orig.)
Discrete symmetries and coset space dimensional reduction
International Nuclear Information System (INIS)
Kapetanakis, D.; Zoupanos, G.
1989-01-01
We consider the discrete symmetries of all the six-dimensional coset spaces and we apply them in gauge theories defined in ten dimensions which are dimensionally reduced over these homogeneous spaces. Particular emphasis is given in the consequences of the discrete symmetries on the particle content as well as on the symmetry breaking a la Hosotani of the resulting four-dimensional theory. (orig.)
On discrete models of space-time
International Nuclear Information System (INIS)
Horzela, A.; Kempczynski, J.; Kapuscik, E.; Georgia Univ., Athens, GA; Uzes, Ch.
1992-02-01
Analyzing the Einstein radiolocation method we come to the conclusion that results of any measurement of space-time coordinates should be expressed in terms of rational numbers. We show that this property is Lorentz invariant and may be used in the construction of discrete models of space-time different from the models of the lattice type constructed in the process of discretization of continuous models. (author)
Application of multivariate splines to discrete mathematics
Xu, Zhiqiang
2005-01-01
Using methods developed in multivariate splines, we present an explicit formula for discrete truncated powers, which are defined as the number of non-negative integer solutions of linear Diophantine equations. We further use the formula to study some classical problems in discrete mathematics as follows. First, we extend the partition function of integers in number theory. Second, we exploit the relation between the relative volume of convex polytopes and multivariate truncated powers and giv...
Mohamed, Mamdouh S.
2016-02-11
A conservative discretization of incompressible Navier–Stokes equations is developed based on discrete exterior calculus (DEC). A distinguishing feature of our method is the use of an algebraic discretization of the interior product operator and a combinatorial discretization of the wedge product. The governing equations are first rewritten using the exterior calculus notation, replacing vector calculus differential operators by the exterior derivative, Hodge star and wedge product operators. The discretization is then carried out by substituting with the corresponding discrete operators based on the DEC framework. Numerical experiments for flows over surfaces reveal a second order accuracy for the developed scheme when using structured-triangular meshes, and first order accuracy for otherwise unstructured meshes. By construction, the method is conservative in that both mass and vorticity are conserved up to machine precision. The relative error in kinetic energy for inviscid flow test cases converges in a second order fashion with both the mesh size and the time step.
Theoretical Basics of Teaching Discrete Mathematics
Directory of Open Access Journals (Sweden)
Y. A. Perminov
2012-01-01
Full Text Available The paper deals with the research findings concerning the process of mastering the theoretical basics of discrete mathematics by the students of vocational pedagogic profile. The methodological analysis is based on the subject and functions of the modern discrete mathematics and its role in mathematical modeling and computing. The modern discrete mathematics (i.e. mathematics of the finite type structures plays the important role in modernization of vocational training. It is especially rele- vant to training students for vocational pedagogic qualifications, as in the future they will be responsible for training the middle and the senior level specialists in engineer- ing and technical spheres. Nowadays in different industries, there arise the problems which require for their solving both continual – based on the classical mathematical methods – and discrete modeling. The teaching course of discrete mathematics for the future vocational teachers should be relevant to the target qualification and aimed at mastering the mathematical modeling, systems of computer mathematics and computer technologies. The author emphasizes the fundamental role of mastering the language of algebraic and serial structures, as well as the logical, algorithmic, combinatory schemes dominating in dis- crete mathematics. The guidelines for selecting the content of the course in discrete mathematics are specified. The theoretical findings of the research can be put into practice whilst developing curricula and working programs for bachelors and masters’ training.
Recent developments in discrete ordinates electron transport
International Nuclear Information System (INIS)
Morel, J.E.; Lorence, L.J. Jr.
1986-01-01
The discrete ordinates method is a deterministic method for numerically solving the Boltzmann equation. It was originally developed for neutron transport calculations, but is routinely used for photon and coupled neutron-photon transport calculations as well. The computational state of the art for coupled electron-photon transport (CEPT) calculations is not as developed as that for neutron transport calculations. The only production codes currently available for CEPT calculations are condensed-history Monte Carlo codes such as the ETRAN and ITS codes. A deterministic capability for production calculations is clearly needed. In response to this need, we have begun the development of a production discrete ordinates code for CEPT calculations. The purpose of this paper is to describe the basic approach we are taking, discuss the current status of the project, and present some new computational results. Although further characterization of the coupled electron-photon discrete ordinates method remains to be done, the results to date indicate that the discrete ordinates method can be just as accurate and from 10 to 100 times faster than the Monte Carlo method for a wide variety of problems. We stress that these results are obtained with standard discrete ordinates codes such as ONETRAN. It is clear that even greater efficiency can be obtained by developing a new generation of production discrete ordinates codes specifically designed to solve the Boltzmann-Fokker-Planck equation. However, the prospects for such development in the near future appear to be remote
Discrete modeling considerations in multiphase fluid dynamics
International Nuclear Information System (INIS)
Ransom, V.H.; Ramshaw, J.D.
1988-01-01
The modeling of multiphase flows play a fundamental role in light water reactor safety. The main ingredients in our discrete modeling Weltanschauung are the following considerations: (1) Any physical model must be cast into discrete form for a digital computer. (2) The usual approach of formulating models in differential form and then discretizing them is potentially hazardous. It may be preferable to formulate the model in discrete terms from the outset. (3) Computer time and storage constraints limit the resolution that can be employed in practical calculations. These limits effectively define the physical phenomena, length scales, and time scales which cannot be directly represented in the calculation and therefore must be modeled. This information should be injected into the model formulation process at an early stage. (4) Practical resolution limits are generally so coarse that traditional convergence and truncation-error analyses become irrelevant. (5) A discrete model constitutes a reduced description of a physical system, from which fine-scale details are eliminated. This elimination creates a statistical closure problem. Methods from statistical physics may therefore be useful in the formulation of discrete models. In the present paper we elaborate on these themes and illustrate them with simple examples. 48 refs
Discrete symmetries and their stringy origin
International Nuclear Information System (INIS)
Mayorga Pena, Damian Kaloni
2014-05-01
Discrete symmetries have proven to be very useful in controlling the phenomenology of theories beyond the standard model. In this work we explore how these symmetries emerge from string compactifications. Our approach is twofold: On the one hand, we consider the heterotic string on orbifold backgrounds. In this case the discrete symmetries can be derived from the orbifold conformal field theory, and it can be shown that they are in close relation with the orbifold geometry. We devote special attention to R-symmetries, which arise from discrete remnants of the Lorentz group in compact space. Further we discuss the physical implications of these symmetries both in the heterotic mini-landscape and in newly constructed models based on the Z 2 x Z 4 orbifold. In both cases we observe that the discrete symmetries favor particular locations in the orbifold where the particles of standard model should live. On the other hand we consider a class of F-theory models exhibiting an SU(5) gauge group, times additional U(1) symmetries. In this case, the smooth compactification background does not permit us to track the discrete symmetries as transparently as in orbifold models. Hence, we follow a different approach and search for discrete subgroups emerging after the U(1)s are broken. We observe that in this approach it is possible to obtain the standard Z 2 matter parity of the MSSM.
BOOK REVIEW: Discrete Symmetries and CP Violation: From Experiment to Theory (Oxford Graduate Texts)
Fösel, A.
2009-03-01
Discrete Symmetries and CP Violation: From Experiment to Theory by Marco Sozzi discusses C(harge conjugation), P(arity) and T(ime reversal) discrete symmetries and of course CP symmetry in microscopic (atomic, nuclear and particle) physics. It includes a detailed description of key or representative experiments, and major achievements and recent developments are also mentioned. Though lots of excellent textbooks already exist which cover the basics of discrete symmetries and CP violation in theory and experiment, Sozzi has fully achieved the goal of presenting a book that describes the basics of this subject in detail, from an experimental point of view as well as from theory. He also succeeds in finding links between experiments and theory, leading to a better understanding of the subject. Besides, as an experimentalist, discrete symmetries and CP violation appear to the author as ideal subjects to convey the depth and excitement of experimental `beautiful' physics, which Marco S Sozzi - in my opinion - has managed to do brilliantly. Though mainly addressed to graduate students, the book may also be useful to undergraduates (by skipping some of the more advanced sections and utilizing the brief introduction to some topics in the appendices) and to young researchers looking for a wider modern overview of the issues related to CP symmetry. At the end of each chapter, further reading sections are conveniently provided for the reader to find relevant literature for further studies. Problems to solve at the end of each chapter act as 'little tests'. Unfortunately, their solutions are currently absent: perhaps a publication that includes them is planned in the near future. To conclude, the book succeeds in being a complete and self-consistent text describing in up-to-date detail the investigation of discrete symmetries in sub-atomic physics. It also emphasizes the concepts and ingenuity behind many delicate, careful, and by all means 'beautiful' experiments.
How to construct self/anti-self charge conjugate states?
International Nuclear Information System (INIS)
Dvoeglazov, V V
2014-01-01
We construct self/anti–self charge conjugate (Majorana–like) states for the (1/2, 0)⊕(0, 1/2) representation of the Lorentz group, and their analogs for higher spins within the quantum field theory. The problem of the basis rotations and that of the selection of phases in the Dirac–like and Majorana–like field operators are considered. The discrete symmetries properties (P, C, T) are studied. The corresponding dynamical equations are presented. In the (1/2, 0) ⊕ (0, 1/2) representation they obey the Dirac–like equation with eight components, which has been first introduced by Markov. Thus, the Fock space for corresponding quantum fields is doubled (as shown by Ziino). The particular attention has been paid to the questions of chirality and helicity (two concepts which are frequently confused in the literature) for Dirac and Majorana states. We further review several experimental consequences which follow from the previous works of M. Kirchbach et al. on neutrinoless double beta decay, and G. J. Ni et al. on meson lifetimes
Evolution of mechanics in α-helical peptide conjugated linear- and star-block PEG.
O'Neill, S C; Bhuiyan, Z H; Tu, R S
2017-10-25
We have designed a peptide conjugated poly-ethylene glycol (PEG) bioconjugate system that allows us to examine the intra- and inter-molecular dynamics of gelation. We measure the kinetics of gelation for end-functionalized linear- and star-architectures, and we correlate the gelation behavior with the molecular structure and self-association. The 23-amino acid peptide sequence is known to form a coiled-coil structure as a function of the solution's electrolyte concentration, and the two topologies of the PEG are peptide end-functionalized to examine formation of supramolecular assemblies. Subsequently, microrheology is used to evaluate the dynamics of self-assembly and the gelation time-scales. This study shows that the dynamics of peptide folding and assembly for linear-PEG conjugated systems yield a percolated network, but the star-PEG conjugated systems yield discrete assemblies and remain viscous. The results suggest that the degree of intra- and inter-molecular folding defines the critical gel behavior of the supramolecular system.
Cross-conjugation and quantum interference: a general correlation?
DEFF Research Database (Denmark)
Valkenier, Hennie; Guedon, Constant M.; Markussen, Troels
2014-01-01
-conjugation patterns, but identical lengths, i.e. an anthracene (linear conjugation), an anthraquinone (cross-conjugation), and a dihydroanthracene (broken conjugation) derivative. To benchmark reliable trends, conductance experiments on these series have been performed by various techniques. Here, we compare data...... characterized by beta = 0.37 +/- 0.03 angstrom(-1) (CP-AFM). Remarkably, for the second series, we do not only find that the linearly conjugated anthracene-containing wire is the most conductive, but also that the cross-conjugated anthraquinone-containing wire is less conductive than the broken...
Phase conjugate Michelson interferometer for optical logic
Khoury, Jed
2017-05-01
The interference theory is developed for of the phase conjugate Michelson interferometer in which its ordinary mirrors are replaced by a single externally pumped phase conjugate mirror. According to the theory, it was found that for an interferometer with two equal arms, the path length difference depends solely on the initial alignment of the two input beams, and the vertical alignment readout. Small vertical misalignments in the readout beam by mrad causes a huge change in the phase difference in the phase between the two interferometer arms beam. The phase difference is proportional to the interferometer arm lengths. The overlap between the phase conjugate beams is not affected by the interferometer beam alignment. The interferometer is proposed for nondestructive testing and the design all optical logic and associated fuzzy logic for ultrafast optical pattern recognition.
Tight-binding treatment of conjugated polymers
DEFF Research Database (Denmark)
Lynge, Thomas Bastholm
This PhD thesis concerns conjugated polymers which constitute a constantly growing research area. Today, among other things, conjugated polymers play a role in plastic based solar cells, photodetectors and light emitting diodes, and even today such plastic-based components constitute an alternative...... of tomorrow. This thesis specifically treats the three conjugated polymers trans-polyacetylene (tPA), poly(para-phenylene) (PPP) and poly(para-phe\\-nylene vinylene) (PPV). The present results, which are derived within the tight-binding model, are divided into two parts. In one part, analytic results...... are derived for the optical properties of the polymers expressed in terms of the optical susceptibility both in the presence and in the absence of a static electric field. In the other part, the cumputationally efficient Density Functional-based Tight-Binding (DFTB) model is applied to the description...
Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience
Directory of Open Access Journals (Sweden)
Jacqueline M. Miller
2011-01-01
Full Text Available Meningococcal diseases are serious threats to global health, and new vaccines specifically tailored to meet the age-related needs of various geographical areas are required. This paper focuses on the meningococcal conjugate vaccines developed by GSK Biologicals. Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningococcal serogroup C or serogroup C and Y disease is important: Hib-MenC-TT vaccine, which offers protection against Haemophilus influenzae type b and Neisseria meningitidis serogroup C diseases, is approved in several countries; and Hib-MenCY-TT vaccine, which adds N. meningitidis serogroup Y antigen, is currently in the final stages of development. Additionally, a tetravalent conjugate vaccine (MenACWY-TT designed to help protect against four meningococcal serogroups is presently being evaluated for global use in all age groups. All of these vaccines were shown to be highly immunogenic and to have clinically acceptable safety profiles.
Nonlinear conjugate gradient methods in micromagnetics
Directory of Open Access Journals (Sweden)
J. Fischbacher
2017-04-01
Full Text Available Conjugate gradient methods for energy minimization in micromagnetics are compared. The comparison of analytic results with numerical simulation shows that standard conjugate gradient method may fail to produce correct results. A method that restricts the step length in the line search is introduced, in order to avoid this problem. When the step length in the line search is controlled, conjugate gradient techniques are a fast and reliable way to compute the hysteresis properties of permanent magnets. The method is applied to investigate demagnetizing effects in NdFe12 based permanent magnets. The reduction of the coercive field by demagnetizing effects is μ0ΔH = 1.4 T at 450 K.
Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience
Miller, Jacqueline M.; Mesaros, Narcisa; Van Der Wielen, Marie; Baine, Yaela
2011-01-01
Meningococcal diseases are serious threats to global health, and new vaccines specifically tailored to meet the age-related needs of various geographical areas are required. This paper focuses on the meningococcal conjugate vaccines developed by GSK Biologicals. Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningococcal serogroup C or serogroup C and Y disease is important: Hib-MenC-TT vaccine, which offers protection against Haemophilus influenzae type b and Neisseria meningitidis serogroup C diseases, is approved in several countries; and Hib-MenCY-TT vaccine, which adds N. meningitidis serogroup Y antigen, is currently in the final stages of development. Additionally, a tetravalent conjugate vaccine (MenACWY-TT) designed to help protect against four meningococcal serogroups is presently being evaluated for global use in all age groups. All of these vaccines were shown to be highly immunogenic and to have clinically acceptable safety profiles. PMID:21991444
Serogroup A meningococcal conjugate vaccines in Africa.
Kristiansen, Paul A; Jørgensen, Hannah J; Caugant, Dominique A
2015-01-01
Serogroup A meningococcal epidemics have been a recurrent public health problem, especially in resource-poor countries of Africa. Recently, the administration in mass vaccination campaigns of a single dose of the monovalent meningococcal conjugate vaccine, MenAfriVac, to the 1-29 year-old population of sub-Saharan Africa has prevented epidemics of meningitis caused by serogroup A Neisseria meningitidis. This strategy has also been shown to provide herd protection of the non-vaccinated population. Development of meningococcal conjugate vaccines covering other serogroups and enhanced use of the pneumococcal and Haemophilus influenzae type b conjugate vaccines must be pursued to fully control bacterial meningitis in sub-Saharan Africa.
Conjugate gradient algorithms using multiple recursions
Energy Technology Data Exchange (ETDEWEB)
Barth, T.; Manteuffel, T.
1996-12-31
Much is already known about when a conjugate gradient method can be implemented with short recursions for the direction vectors. The work done in 1984 by Faber and Manteuffel gave necessary and sufficient conditions on the iteration matrix A, in order for a conjugate gradient method to be implemented with a single recursion of a certain form. However, this form does not take into account all possible recursions. This became evident when Jagels and Reichel used an algorithm of Gragg for unitary matrices to demonstrate that the class of matrices for which a practical conjugate gradient algorithm exists can be extended to include unitary and shifted unitary matrices. The implementation uses short double recursions for the direction vectors. This motivates the study of multiple recursion algorithms.
CO-releasing molecule (CORM) conjugate systems.
Kautz, Anna Christin; Kunz, Peter C; Janiak, Christoph
2016-11-15
The development of CORMs (CO-releasing molecules) as a prodrug for CO administration in living organisms has attracted significant attention. CORMs offer the promising possibility of a safe and controllable release of CO in low amounts triggered by light, ligands, enzymes, etc. For the targeting of specific tissues or diseases and to prevent possible side effects from metals and other residues after CO release, these CORMs are attached to biocompatible systems, like peptides, polymers, nanoparticles, dendrimers, protein cages, non-wovens, tablets, and metal-organic frameworks. We discuss in this review the known CORM carrier conjugates, in short CORM conjugates, with covalently-bound or incorporated CORMs for medicinal and therapeutic applications. Most conjugates are nontoxic, show increasing half-lives of CO release, and make use of the EPR-effect, but still show problems because of a continuous background of CO release and the absence of an on/off-switch for the CO release.
Conjugated Polymers as Actuators: Modes of Actuation
DEFF Research Database (Denmark)
Skaarup, Steen
2004-01-01
The physical and chemical properties of conjugated polymers often depend very strongly on the degree of doping with anions or cations. The movement of ions in and out of the polymer matrix as it is redox cycled is also accompanied by mechanical changes. Both the volume and the stiffness can exhibit...... significant differences between the oxidized and reduced states. These effects form the basis of the use of conjugated polymers as actuators (or “artificial muscles”) controllable by a small (1-10 V) voltage. Three basic modes of actuation (bending, linear extension and stiffness change) have been proposed...
Functionalized conjugated polyelectrolytes design and biomedical applications
Wang, Shu
2014-01-01
Functionalized Conjugated Polyelectrolytes presents a comprehensive review of these polyelectrolytes and their biomedical applications. Basic aspects like molecular design and optoelectronic properties are covered in the first chapter. Emphasis is placed on the various applications including sensing (chemical and biological), disease diagnosis, cell imaging, drug/gene delivery and disease treatment. This book explores a multi-disciplinary topic of interest to researchers working in the fields of chemistry, materials, biology and medicine. It also offers an integrated perspective on both basic research and application issues. Functionalized conjugated polyelectrolyte materials, which have already drawn considerable interest, will become a major new direction for biomedicine development.
Conjugated polymers as actuators: modes of actuation
DEFF Research Database (Denmark)
Skaarup, Steen
2007-01-01
The physical and chemical properties of conjugated polymers often depend very strongly on the degree of doping with anions or cations. The movement of ions in and out of the polymer matrix as it is redox cycled is also accompanied by mechanical changes. Both the volume and the stiffness can exhibit...... significant differences between the oxidized and reduced states. These effects form the basis of the use of conjugated polymers as actuators (or “artificial muscles”) controllable by a small (1-10 V) voltage. Three basic modes of actuation (bending, linear extension and stiffness change) have been proposed...
De-conjugation behavior of conjugated estrogens in the raw sewage, activated sludge and river water.
Kumar, Vimal; Johnson, Andrew C; Nakada, Norihide; Yamashita, Naoyuki; Tanaka, Hiroaki
2012-08-15
The fate and behavior of estrone-3-sulfate (E1-3S), estradiol-3-sulfate (E2-3S), estrone-3-glucuronide (E1-3G) and estradiol-3-glucuronide (E2-3G) were studied in raw sewage, activated sludge and river water using microcosms. The glucuronide conjugates had a half-life of 0.4h in raw sewage, yielding 40-60% of their free estrogens. Field observations at three activated sludge processes suggested complete transformation of the glucuronide conjugates in the sewer. In river water glucuronide conjugates half-lives extended to over 2d yielding 60-100% of their free parent estrogens. Transformation of the sulfate conjugates in raw sewage and river water was slow with little formation of the parent estrogens. Sulfate conjugates could readily be detected in sewage influent in the field studies. In activated sludge the sulfate conjugates had half-lives of 0.2h with the transient formation of 10-55% of the free parent estrogens. Field studies indicated transformation of sulfate conjugates across the sewage treatment, although a proportion escaped into the effluent. These results broadly support the view that glucuronide conjugates will be entirely transformed within the sewer largely to their parent estrogens. The sulfate conjugates may persist in raw sewage and river water but are transformable in activated sludge and, in the case of E2-3S, reform a high proportion of the parent estrogen. Copyright © 2012 Elsevier B.V. All rights reserved.
Geri, I; Ozkul, C
1996-11-01
The temporal evolution of double phase-conjugate mirrors (DPCM's) in photorefractive materials such as BaTiO(3):Co:Fe is studied by use of the plane-wave expansion method. The buildup time of DPCM and its conjugation fidelity are compared with those of photorefractive materials with a single-center transport. Numerical simulations show that one can decrease the threshold value of the coupling strength required for the DPCM operation with a high conjugation fidelity by doping the BaTiO(3) crystals weakly with Co in comparison with undoped crystals.
Discrete Feature Model (DFM) User Documentation
International Nuclear Information System (INIS)
Geier, Joel
2008-06-01
This manual describes the Discrete-Feature Model (DFM) software package for modelling groundwater flow and solute transport in networks of discrete features. A discrete-feature conceptual model represents fractures and other water-conducting features around a repository as discrete conductors surrounded by a rock matrix which is usually treated as impermeable. This approximation may be valid for crystalline rocks such as granite or basalt, which have very low permeability if macroscopic fractures are excluded. A discrete feature is any entity that can conduct water and permit solute transport through bedrock, and can be reasonably represented as a piecewise-planar conductor. Examples of such entities may include individual natural fractures (joints or faults), fracture zones, and disturbed-zone features around tunnels (e.g. blasting-induced fractures or stress-concentration induced 'onion skin' fractures around underground openings). In a more abstract sense, the effectively discontinuous nature of pathways through fractured crystalline bedrock may be idealized as discrete, equivalent transmissive features that reproduce large-scale observations, even if the details of connective paths (and unconnected domains) are not precisely known. A discrete-feature model explicitly represents the fundamentally discontinuous and irregularly connected nature of systems of such systems, by constraining flow and transport to occur only within such features and their intersections. Pathways for flow and solute transport in this conceptualization are a consequence not just of the boundary conditions and hydrologic properties (as with continuum models), but also the irregularity of connections between conductive/transmissive features. The DFM software package described here is an extensible code for investigating problems of flow and transport in geological (natural or human-altered) systems that can be characterized effectively in terms of discrete features. With this software, the
Discrete Feature Model (DFM) User Documentation
Energy Technology Data Exchange (ETDEWEB)
Geier, Joel (Clearwater Hardrock Consulting, Corvallis, OR (United States))
2008-06-15
This manual describes the Discrete-Feature Model (DFM) software package for modelling groundwater flow and solute transport in networks of discrete features. A discrete-feature conceptual model represents fractures and other water-conducting features around a repository as discrete conductors surrounded by a rock matrix which is usually treated as impermeable. This approximation may be valid for crystalline rocks such as granite or basalt, which have very low permeability if macroscopic fractures are excluded. A discrete feature is any entity that can conduct water and permit solute transport through bedrock, and can be reasonably represented as a piecewise-planar conductor. Examples of such entities may include individual natural fractures (joints or faults), fracture zones, and disturbed-zone features around tunnels (e.g. blasting-induced fractures or stress-concentration induced 'onion skin' fractures around underground openings). In a more abstract sense, the effectively discontinuous nature of pathways through fractured crystalline bedrock may be idealized as discrete, equivalent transmissive features that reproduce large-scale observations, even if the details of connective paths (and unconnected domains) are not precisely known. A discrete-feature model explicitly represents the fundamentally discontinuous and irregularly connected nature of systems of such systems, by constraining flow and transport to occur only within such features and their intersections. Pathways for flow and solute transport in this conceptualization are a consequence not just of the boundary conditions and hydrologic properties (as with continuum models), but also the irregularity of connections between conductive/transmissive features. The DFM software package described here is an extensible code for investigating problems of flow and transport in geological (natural or human-altered) systems that can be characterized effectively in terms of discrete features. With this
Efficient Xerographic Photoreceptors from Conjugated Polymers and Polymer Blends
National Research Council Canada - National Science Library
Zhang, Xuejun, Ph.D
1998-01-01
Bilayer xerographic photoreceptors in which pi-conjugated polymers and binary conjugated polymer blends are used as the charge generation layer have been fabricated, evaluated, and shown to be highly efficient...
Convergence of posteriors for discretized log Gaussian Cox processes
DEFF Research Database (Denmark)
Waagepetersen, Rasmus Plenge
2004-01-01
In Markov chain Monte Carlo posterior computation for log Gaussian Cox processes (LGCPs) a discretization of the continuously indexed Gaussian field is required. It is demonstrated that approximate posterior expectations computed from discretized LGCPs converge to the exact posterior expectations...... when the cell sizes of the discretization tends to zero. The effect of discretization is studied in a data example....
Continuum limit of discrete Sommerfeld problems on square lattice
Indian Academy of Sciences (India)
A low-frequency approximation of the discrete Sommerfeld diffraction problems, involving the scattering of a time harmonic lattice wave incident on square lattice by a discrete Dirichlet or a discrete Neumann half-plane, is investigated. It is established that the exact solution of the discrete model converges to the solution of ...
Positivity for Convective Semi-discretizations
Fekete, Imre
2017-04-19
We propose a technique for investigating stability properties like positivity and forward invariance of an interval for method-of-lines discretizations, and apply the technique to study positivity preservation for a class of TVD semi-discretizations of 1D scalar hyperbolic conservation laws. This technique is a generalization of the approach suggested in Khalsaraei (J Comput Appl Math 235(1): 137–143, 2010). We give more relaxed conditions on the time-step for positivity preservation for slope-limited semi-discretizations integrated in time with explicit Runge–Kutta methods. We show that the step-size restrictions derived are sharp in a certain sense, and that many higher-order explicit Runge–Kutta methods, including the classical 4th-order method and all non-confluent methods with a negative Butcher coefficient, cannot generally maintain positivity for these semi-discretizations under any positive step size. We also apply the proposed technique to centered finite difference discretizations of scalar hyperbolic and parabolic problems.
Discrete Localized States and Localization Dynamics in Discrete Nonlinear Schrödinger Equations
DEFF Research Database (Denmark)
Christiansen, Peter Leth; Gaididei, Yu.B.; Mezentsev, V.K.
1996-01-01
Dynamics of two-dimensional discrete structures is studied in the framework of the generalized two-dimensional discrete nonlinear Schrodinger equation. The nonlinear coupling in the form of the Ablowitz-Ladik nonlinearity is taken into account. Stability properties of the stationary solutions...
Functional analysis of the conjugation system from Clostridium perfringens
Wisniewski, Jessica Ann
2017-01-01
In Clostridium perfringens, toxins that cause histotoxic and gastrointestinal diseases have been identified on a family of large conjugative plasmids. The tcp transfer locus was initially identified on the prototype conjugative plasmid, pCW3. This locus has been shown to mediate conjugative plasmid transfer and studies on several of the Tcp proteins have identified their role in plasmid transfer. In general less is known about the mechanism of conjugative transfer in Gram positive bacteria, n...
Women experiencing the intergenerationality of conjugal violence
Directory of Open Access Journals (Sweden)
Gilvânia Patrícia do Nascimento Paixão
2015-10-01
Full Text Available Objective: to analyze the family relationship, in childhood and adolescence, of women who experience conjugal violence.Method: qualitative study. Interviews were held with 19 women, who were experiencing conjugal violence, and who were resident in a community in Salvador, Bahia, Brazil. The project was approved by the Research Ethics Committee (N. 42/2011.Results: the data was organized using the Discourse of the Collective Subject, identifying the summary central ideas: they witnessed violence between their parents; they suffered repercussions from the violence between their parents: they were angry about the mother's submission to her partner; and they reproduced the conjugal violence. The discourse showed that the women witnessed, in childhood and adolescence, violence between their parents, and were injured both physically and psychologically. As a result of the mother's submission, feelings of anger arose in the children. However, in the adult phase of their own lives, they noticed that their conjugal life resembled that of their parents, reproducing the violence.Conclusion: investment is necessary in strategies designed to break inter-generational violence, and the health professionals are important in this process, as it is a phenomenon with repercussions in health. Because they work in the Family Health Strategy, which focuses on the prevention of harm and illness, health promotion and interdepartmentality, the nurses are essential in the process of preventing and confronting this phenomenon.
Women experiencing the intergenerationality of conjugal violence.
Paixão, Gilvânia Patrícia do Nascimento; Gomes, Nadirlene Pereira; Diniz, Normélia Maria Freire; Carvalho e Lira, Margaret Ollinda de Souza; Carvalho, Milca Ramaiane da Silva; da Silva, Rudval Souza
2015-01-01
to analyze the family relationship, in childhood and adolescence, of women who experience conjugal violence. qualitative study. Interviews were held with 19 women, who were experiencing conjugal violence, and who were resident in a community in Salvador, Bahia, Brazil. The project was approved by the Research Ethics Committee (N. 42/2011). the data was organized using the Discourse of the Collective Subject, identifying the summary central ideas: they witnessed violence between their parents; they suffered repercussions from the violence between their parents: they were angry about the mother's submission to her partner; and they reproduced the conjugal violence. The discourse showed that the women witnessed, in childhood and adolescence, violence between their parents, and were injured both physically and psychologically. As a result of the mother's submission, feelings of anger arose in the children. However, in the adult phase of their own lives, they noticed that their conjugal life resembled that of their parents, reproducing the violence. investment is necessary in strategies designed to break inter-generational violence, and the health professionals are important in this process, as it is a phenomenon with repercussions in health. Because they work in the Family Health Strategy, which focuses on the prevention of harm and illness, health promotion and interdepartmentality, the nurses are essential in the process of preventing and confronting this phenomenon.
Unsymmetrical extended -conjugated zinc phthalocyanine for ...
Indian Academy of Sciences (India)
We have designed and synthesized a new unsymmetrical zinc phthalocyanine based on `push-pull' and extended -conjugation concept, PCH008. The new sensitizer was fully characterized by CHN anlysis, UV-Vis., fluorescence spectroscopies and cyclic voltammetry. The new sensitizer which upon anchoring onto ...
Compositions for directed alignment of conjugated polymers
Kim, Jinsang; Kim, Bong-Gi; Jeong, Eun Jeong
2016-04-19
Conjugated polymers (CPs) achieve directed alignment along an applied flow field and a dichroic ratio of as high as 16.67 in emission from well-aligned thin films and fully realized anisotropic optoelectronic properties of CPs in field-effect transistor (FET).
Theoretical study of conjugated porphyrin polymers
DEFF Research Database (Denmark)
Pedersen, T.G.; Lynge, T.B.; Kristensen, P.K.
2005-01-01
for these applications. From a theoretical analysis of excitons in long metalloporphyrin chains, we demonstrate that the binding energy is much lower than in usual conjugated polymers. Our calculated absorption spectra are in good agreement with measurements. (c) 2004 Elsevier B.V. All rights reserved....
preconditioning the modified conjugate gradient method
African Journals Online (AJOL)
Admin
The conventional conjugate method (CGM) was originally developed by Hestenes and. Stiefel (1952) as a method of solution for linear systems. Fletcher and Reeves (1964) built the necessary underlying theory for a successful application of the method to quadratic functional and developed its convergence properties.
Ciprofloxacin conjugated zinc oxide nanoparticle: A camouflage ...
Indian Academy of Sciences (India)
excellent antibacterial activity against clinically isolated multidrug resistant bacterial strains of Escherichia coli,. Staphylococcus aureus and ... Keywords. Zinc oxide nanoparticles; ciprofloxacin; chemical conjugation; antibacterial property. 1. Introduction ... Nanoparticles of TiO2, ZnO, silver, etc. are commonly known for their ...
Bacillus thuringiensis Conjugation in Simulated Microgravity
Beuls, Elise; van Houdt, Rob; Leys, Natalie; Dijkstra, Camelia; Larkin, Oliver; Mahillon, Jacques
2009-10-01
Spaceflight experiments have suggested a possible effect of microgravity on the plasmid transfer among strains of the Gram-positive Bacillus thuringiensis, as opposed to no effect recorded for Gram-negative conjugation. To investigate these potential effects in a more affordable experimental setup, three ground-based microgravity simulators were tested: the Rotating Wall Vessel (RWV), the Random Positioning Machine (RPM), and a superconducting magnet. The bacterial conjugative system consisted in biparental matings between two B. thuringiensis strains, where the transfer frequencies of the conjugative plasmid pAW63 and its ability to mobilize the nonconjugative plasmid pUB110 were assessed. Specifically, potential plasmid transfers in a 0-g position (simulated microgravity) were compared to those obtained under 1-g (normal gravity) condition in each device. Statistical analyses revealed no significant difference in the conjugative and mobilizable transfer frequencies between the three different simulated microgravitational conditions and our standard laboratory condition. These important ground-based observations emphasize the fact that, though no stimulation of plasmid transfer was observed, no inhibition was observed either. In the case of Gram-positive bacteria, this ability to exchange plasmids in weightlessness, as occurs under Earth's conditions, should be seen as particularly relevant in the scope of spread of antibiotic resistances and bacterial virulence.
Conjugated Polymer Actuators: Prospects and Limitations
DEFF Research Database (Denmark)
Skaarup, Steen
2007-01-01
Actuators constructed with a conjugated polymer as the active part have been predicted to have a number of highly desirable properties: Large mechanical strength, high power density, i.e. high actuation speeds possible, sufficient maximum strain values, high reversibility and safe, low voltages (1...
Immunogenicity of novel sulfadimethoxide conjugates | Chen ...
African Journals Online (AJOL)
Immunogenicity of novel sulfadimethoxide conjugates. L Chen, J Su, X Zhang, L Li, X He. Abstract. Sulfadimethoxine (SDM) is an antibiotic commonly added to animal feeds. Anti-SDM antibodies are useful for the detection of residual SDM in foods, feeds and biological fluids by ELISA. In this study, we show that SDM is ...
Theory of periodic conjugate heat transfer
Zudin, Yuri B
2016-01-01
This book presents the theory of periodic conjugate heat transfer in detail. It offers a simplified description of the interaction between a solid body and a fluid as a boundary value problem of the heat conduction equation for the solid body.
Meningococcal conjugate vaccines: optimizing global impact
Directory of Open Access Journals (Sweden)
Terranella A
2011-09-01
Full Text Available Andrew Terranella1,2, Amanda Cohn2, Thomas Clark2 1Epidemic Intelligence Service, Division of Applied Sciences, Scientific Education and Professional Development Program Office, 2Meningitis and Vaccine Preventable Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA Abstract: Meningococcal conjugate vaccines have several advantages over polysaccharide vaccines, including the ability to induce greater antibody persistence, avidity, immunologic memory, and herd immunity. Since 1999, meningococcal conjugate vaccine programs have been established across the globe. Many of these vaccination programs have resulted in significant decline in meningococcal disease in several countries. Recent introduction of serogroup A conjugate vaccine in Africa offers the potential to eliminate meningococcal disease as a public health problem in Africa. However, the duration of immune response and the development of widespread herd immunity in the population remain important questions for meningococcal vaccine programs. Because of the unique epidemiology of meningococcal disease around the world, the optimal vaccination strategy for long-term disease prevention will vary by country. Keywords: conjugate vaccine, meningitis, meningococcal vaccine, meningococcal disease
One-pot synthesis of conjugated trienes
Czech Academy of Sciences Publication Activity Database
Šebesta, Petr; Jahn, Ullrich
2009-01-01
Roč. 103, č. 11 (2009), s. 990-990 ISSN 0009-2770. [Pokroky v organické, bioorganické a farmaceutické chemii /44./. 27.11.2009-29.11.2009, Liblice] Institutional research plan: CEZ:AV0Z40550506 Keywords : pheromones * Suzuki coupling * conjugated trienes Subject RIV: CC - Organic Chemistry
Determinants of pneumococcal conjugate vaccine uptake among ...
African Journals Online (AJOL)
Subjects: The respondents were the parents/guardians of children less than two years of age attending immunisation services at KNH and those admitted in the peadiatric wards with pneumonia. Results: The study established that the determinants of uptake of Pneumococcal Conjugate Vaccine are age(OR 5.8, CI 1.4-23.4, ...
Modeling discrete time-to-event data
Tutz, Gerhard
2016-01-01
This book focuses on statistical methods for the analysis of discrete failure times. Failure time analysis is one of the most important fields in statistical research, with applications affecting a wide range of disciplines, in particular, demography, econometrics, epidemiology and clinical research. Although there are a large variety of statistical methods for failure time analysis, many techniques are designed for failure times that are measured on a continuous scale. In empirical studies, however, failure times are often discrete, either because they have been measured in intervals (e.g., quarterly or yearly) or because they have been rounded or grouped. The book covers well-established methods like life-table analysis and discrete hazard regression models, but also introduces state-of-the art techniques for model evaluation, nonparametric estimation and variable selection. Throughout, the methods are illustrated by real life applications, and relationships to survival analysis in continuous time are expla...
Designing perturbative metamaterials from discrete models.
Matlack, Kathryn H; Serra-Garcia, Marc; Palermo, Antonio; Huber, Sebastian D; Daraio, Chiara
2018-04-01
Identifying material geometries that lead to metamaterials with desired functionalities presents a challenge for the field. Discrete, or reduced-order, models provide a concise description of complex phenomena, such as negative refraction, or topological surface states; therefore, the combination of geometric building blocks to replicate discrete models presenting the desired features represents a promising approach. However, there is no reliable way to solve such an inverse problem. Here, we introduce 'perturbative metamaterials', a class of metamaterials consisting of weakly interacting unit cells. The weak interaction allows us to associate each element of the discrete model with individual geometric features of the metamaterial, thereby enabling a systematic design process. We demonstrate our approach by designing two-dimensional elastic metamaterials that realize Veselago lenses, zero-dispersion bands and topological surface phonons. While our selected examples are within the mechanical domain, the same design principle can be applied to acoustic, thermal and photonic metamaterials composed of weakly interacting unit cells.
Symmetric, discrete fractional splines and Gabor systems
DEFF Research Database (Denmark)
Søndergaard, Peter Lempel
2006-01-01
In this paper we consider fractional splines as windows for Gabor frames. We introduce two new types of symmetric, fractional splines in addition to one found by Unser and Blu. For the finite, discrete case we present two families of splines: One is created by sampling and periodizing the continu......In this paper we consider fractional splines as windows for Gabor frames. We introduce two new types of symmetric, fractional splines in addition to one found by Unser and Blu. For the finite, discrete case we present two families of splines: One is created by sampling and periodizing...... the continuous splines, and one is a truly finite, discrete construction. We discuss the properties of these splines and their usefulness as windows for Gabor frames and Wilson bases....
The ultimatum game: Discrete vs. continuous offers
Dishon-Berkovits, Miriam; Berkovits, Richard
2014-09-01
In many experimental setups in social-sciences, psychology and economy the subjects are requested to accept or dispense monetary compensation which is usually given in discrete units. Using computer and mathematical modeling we show that in the framework of studying the dynamics of acceptance of proposals in the ultimatum game, the long time dynamics of acceptance of offers in the game are completely different for discrete vs. continuous offers. For discrete values the dynamics follow an exponential behavior. However, for continuous offers the dynamics are described by a power-law. This is shown using an agent based computer simulation as well as by utilizing an analytical solution of a mean-field equation describing the model. These findings have implications to the design and interpretation of socio-economical experiments beyond the ultimatum game.
Is Fitts' law continuous in discrete aiming?
Directory of Open Access Journals (Sweden)
Rita Sleimen-Malkoun
Full Text Available The lawful continuous linear relation between movement time and task difficulty (i.e., index of difficulty; ID in a goal-directed rapid aiming task (Fitts' law has been recently challenged in reciprocal performance. Specifically, a discontinuity was observed at critical ID and was attributed to a transition between two distinct dynamic regimes that occurs with increasing difficulty. In the present paper, we show that such a discontinuity is also present in discrete aiming when ID is manipulated via target width (experiment 1 but not via target distance (experiment 2. Fitts' law's discontinuity appears, therefore, to be a suitable indicator of the underlying functional adaptations of the neuro-muscular-skeletal system to task properties/requirements, independently of reciprocal or discrete nature of the task. These findings open new perspectives to the study of dynamic regimes involved in discrete aiming and sensori-motor mechanisms underlying the speed-accuracy trade-off.
Stabilizing cations in the backbones of conjugated polymers
Voortman, Thomas P.; de Gier, Hilde D.; Havenith, Remco W. A.; Chiechi, Ryan C.
2014-01-01
We synthesized a cross-conjugated polymer containing ketones in the backbone and converted it to a linearly conjugated, cationic polyarylmethine via a process we call "spinless doping" to create a new class of materials, conjugated polyions. This process involves activating the ketones with a Lewis
DA conjugated polymers containing substituted thiophene, 1, 3, 4 ...
Indian Academy of Sciences (India)
... electron-accepting (A) 1,3,4- oxadiazole unit and non-conjugation linkers. The conjugated segment in P1-P3 contains only five aromatic rings resulting in short conjugation length, but has an alternate D-A arrangement which significantly enhances the intramolecular charge transfer (ICT) interaction within the segment.
Euler-Poincare reduction for discrete field theories
International Nuclear Information System (INIS)
Vankerschaver, Joris
2007-01-01
In this note, we develop a theory of Euler-Poincare reduction for discrete Lagrangian field theories. We introduce the concept of Euler-Poincare equations for discrete field theories, as well as a natural extension of the Moser-Veselov scheme, and show that both are equivalent. The resulting discrete field equations are interpreted in terms of discrete differential geometry. An application to the theory of discrete harmonic mappings is also briefly discussed
Thinning, photonic beamsplitting, and a general discrete entropy power inequality
Guha, Saikat; Shapiro, Jeffrey H.; Sanchez, Raul Garcia-Patron
2016-01-01
Many partially-successful attempts have been made to find the most natural discrete-variable version of Shannon's entropy power inequality (EPI). We develop an axiomatic framework from which we deduce the natural form of a discrete-variable EPI and an associated entropic monotonicity in a discrete-variable central limit theorem. In this discrete EPI, the geometric distribution, which has the maximum entropy among all discrete distributions with a given mean, assumes a role analogous to the Ga...
Cortical Neural Computation by Discrete Results Hypothesis.
Castejon, Carlos; Nuñez, Angel
2016-01-01
One of the most challenging problems we face in neuroscience is to understand how the cortex performs computations. There is increasing evidence that the power of the cortical processing is produced by populations of neurons forming dynamic neuronal ensembles. Theoretical proposals and multineuronal experimental studies have revealed that ensembles of neurons can form emergent functional units. However, how these ensembles are implicated in cortical computations is still a mystery. Although cell ensembles have been associated with brain rhythms, the functional interaction remains largely unclear. It is still unknown how spatially distributed neuronal activity can be temporally integrated to contribute to cortical computations. A theoretical explanation integrating spatial and temporal aspects of cortical processing is still lacking. In this Hypothesis and Theory article, we propose a new functional theoretical framework to explain the computational roles of these ensembles in cortical processing. We suggest that complex neural computations underlying cortical processing could be temporally discrete and that sensory information would need to be quantized to be computed by the cerebral cortex. Accordingly, we propose that cortical processing is produced by the computation of discrete spatio-temporal functional units that we have called "Discrete Results" (Discrete Results Hypothesis). This hypothesis represents a novel functional mechanism by which information processing is computed in the cortex. Furthermore, we propose that precise dynamic sequences of "Discrete Results" is the mechanism used by the cortex to extract, code, memorize and transmit neural information. The novel "Discrete Results" concept has the ability to match the spatial and temporal aspects of cortical processing. We discuss the possible neural underpinnings of these functional computational units and describe the empirical evidence supporting our hypothesis. We propose that fast-spiking (FS
Discrete quantum geometries and their effective dimension
International Nuclear Information System (INIS)
Thuerigen, Johannes
2015-01-01
In several approaches towards a quantum theory of gravity, such as group field theory and loop quantum gravity, quantum states and histories of the geometric degrees of freedom turn out to be based on discrete spacetime. The most pressing issue is then how the smooth geometries of general relativity, expressed in terms of suitable geometric observables, arise from such discrete quantum geometries in some semiclassical and continuum limit. In this thesis I tackle the question of suitable observables focusing on the effective dimension of discrete quantum geometries. For this purpose I give a purely combinatorial description of the discrete structures which these geometries have support on. As a side topic, this allows to present an extension of group field theory to cover the combinatorially larger kinematical state space of loop quantum gravity. Moreover, I introduce a discrete calculus for fields on such fundamentally discrete geometries with a particular focus on the Laplacian. This permits to define the effective-dimension observables for quantum geometries. Analysing various classes of quantum geometries, I find as a general result that the spectral dimension is more sensitive to the underlying combinatorial structure than to the details of the additional geometric data thereon. Semiclassical states in loop quantum gravity approximate the classical geometries they are peaking on rather well and there are no indications for stronger quantum effects. On the other hand, in the context of a more general model of states which are superposition over a large number of complexes, based on analytic solutions, there is a flow of the spectral dimension from the topological dimension d on low energy scales to a real number between 0 and d on high energy scales. In the particular case of 1 these results allow to understand the quantum geometry as effectively fractal.
Digital and discrete geometry theory and algorithms
Chen, Li
2014-01-01
This book provides comprehensive coverage of the modern methods for geometric problems in the computing sciences. It also covers concurrent topics in data sciences including geometric processing, manifold learning, Google search, cloud data, and R-tree for wireless networks and BigData.The author investigates digital geometry and its related constructive methods in discrete geometry, offering detailed methods and algorithms. The book is divided into five sections: basic geometry; digital curves, surfaces and manifolds; discretely represented objects; geometric computation and processing; and a
Hybrid Discrete-Continuous Markov Decision Processes
Feng, Zhengzhu; Dearden, Richard; Meuleau, Nicholas; Washington, Rich
2003-01-01
This paper proposes a Markov decision process (MDP) model that features both discrete and continuous state variables. We extend previous work by Boyan and Littman on the mono-dimensional time-dependent MDP to multiple dimensions. We present the principle of lazy discretization, and piecewise constant and linear approximations of the model. Having to deal with several continuous dimensions raises several new problems that require new solutions. In the (piecewise) linear case, we use techniques from partially- observable MDPs (POMDPS) to represent value functions as sets of linear functions attached to different partitions of the state space.
Logic and discrete mathematics a concise introduction
Conradie, Willem
2015-01-01
A concise yet rigorous introduction to logic and discrete mathematics. This book features a unique combination of comprehensive coverage of logic with a solid exposition of the most important fields of discrete mathematics, presenting material that has been tested and refined by the authors in university courses taught over more than a decade. The chapters on logic - propositional and first-order - provide a robust toolkit for logical reasoning, emphasizing the conceptual understanding of the language and the semantics of classical logic as well as practical applications through the easy
Synchronization Of Parallel Discrete Event Simulations
Steinman, Jeffrey S.
1992-01-01
Adaptive, parallel, discrete-event-simulation-synchronization algorithm, Breathing Time Buckets, developed in Synchronous Parallel Environment for Emulation and Discrete Event Simulation (SPEEDES) operating system. Algorithm allows parallel simulations to process events optimistically in fluctuating time cycles that naturally adapt while simulation in progress. Combines best of optimistic and conservative synchronization strategies while avoiding major disadvantages. Algorithm processes events optimistically in time cycles adapting while simulation in progress. Well suited for modeling communication networks, for large-scale war games, for simulated flights of aircraft, for simulations of computer equipment, for mathematical modeling, for interactive engineering simulations, and for depictions of flows of information.
Efficient discrete Gabor functions for robot vision
Weiman, Carl F. R.
1994-03-01
A new discrete Gabor function provides subpixel resolution of phase while overcoming many of the computational burdens of current approaches to Gabor function implementation. Applications include hyperacuity measurement of binocular disparity and optic flow for stereo vision. Convolution is avoided by exploiting band-pass to subsample the image plane. A general purpose front end processor for robot vision, based on a wavelet interpretation of this discrete Gabor function, can be constructed by tessellating and pyramiding the elementary filter. Computational efficiency opens the door to real-time implementation which mimics many properties of the simple and complex cells in the visual cortex.
Modeling and simulation of discrete event systems
Choi, Byoung Kyu
2013-01-01
Computer modeling and simulation (M&S) allows engineers to study and analyze complex systems. Discrete-event system (DES)-M&S is used in modern management, industrial engineering, computer science, and the military. As computer speeds and memory capacity increase, so DES-M&S tools become more powerful and more widely used in solving real-life problems. Based on over 20 years of evolution within a classroom environment, as well as on decades-long experience in developing simulation-based solutions for high-tech industries, Modeling and Simulation of Discrete-Event Systems is the only book on
Measurement Uncertainty Relations for Discrete Observables: Relative Entropy Formulation
Barchielli, Alberto; Gregoratti, Matteo; Toigo, Alessandro
2018-02-01
We introduce a new information-theoretic formulation of quantum measurement uncertainty relations, based on the notion of relative entropy between measurement probabilities. In the case of a finite-dimensional system and for any approximate joint measurement of two target discrete observables, we define the entropic divergence as the maximal total loss of information occurring in the approximation at hand. For fixed target observables, we study the joint measurements minimizing the entropic divergence, and we prove the general properties of its minimum value. Such a minimum is our uncertainty lower bound: the total information lost by replacing the target observables with their optimal approximations, evaluated at the worst possible state. The bound turns out to be also an entropic incompatibility degree, that is, a good information-theoretic measure of incompatibility: indeed, it vanishes if and only if the target observables are compatible, it is state-independent, and it enjoys all the invariance properties which are desirable for such a measure. In this context, we point out the difference between general approximate joint measurements and sequential approximate joint measurements; to do this, we introduce a separate index for the tradeoff between the error of the first measurement and the disturbance of the second one. By exploiting the symmetry properties of the target observables, exact values, lower bounds and optimal approximations are evaluated in two different concrete examples: (1) a couple of spin-1/2 components (not necessarily orthogonal); (2) two Fourier conjugate mutually unbiased bases in prime power dimension. Finally, the entropic incompatibility degree straightforwardly generalizes to the case of many observables, still maintaining all its relevant properties; we explicitly compute it for three orthogonal spin-1/2 components.
Measurement Uncertainty Relations for Discrete Observables: Relative Entropy Formulation
Barchielli, Alberto; Gregoratti, Matteo; Toigo, Alessandro
2018-01-01
We introduce a new information-theoretic formulation of quantum measurement uncertainty relations, based on the notion of relative entropy between measurement probabilities. In the case of a finite-dimensional system and for any approximate joint measurement of two target discrete observables, we define the entropic divergence as the maximal total loss of information occurring in the approximation at hand. For fixed target observables, we study the joint measurements minimizing the entropic divergence, and we prove the general properties of its minimum value. Such a minimum is our uncertainty lower bound: the total information lost by replacing the target observables with their optimal approximations, evaluated at the worst possible state. The bound turns out to be also an entropic incompatibility degree, that is, a good information-theoretic measure of incompatibility: indeed, it vanishes if and only if the target observables are compatible, it is state-independent, and it enjoys all the invariance properties which are desirable for such a measure. In this context, we point out the difference between general approximate joint measurements and sequential approximate joint measurements; to do this, we introduce a separate index for the tradeoff between the error of the first measurement and the disturbance of the second one. By exploiting the symmetry properties of the target observables, exact values, lower bounds and optimal approximations are evaluated in two different concrete examples: (1) a couple of spin-1/2 components (not necessarily orthogonal); (2) two Fourier conjugate mutually unbiased bases in prime power dimension. Finally, the entropic incompatibility degree straightforwardly generalizes to the case of many observables, still maintaining all its relevant properties; we explicitly compute it for three orthogonal spin-1/2 components.
An inherently parallel method for solving discretized diffusion equations
International Nuclear Information System (INIS)
Eccleston, B.R.; Palmer, T.S.
1999-01-01
A Monte Carlo approach to solving linear systems of equations is being investigated in the context of the solution of discretized diffusion equations. While the technique was originally devised decades ago, changes in computer architectures (namely, massively parallel machines) have driven the authors to revisit this technique. There are a number of potential advantages to this approach: (1) Analog Monte Carlo techniques are inherently parallel; this is not necessarily true to today's more advanced linear equation solvers (multigrid, conjugate gradient, etc.); (2) Some forms of this technique are adaptive in that they allow the user to specify locations in the problem where resolution is of particular importance and to concentrate the work at those locations; and (3) These techniques permit the solution of very large systems of equations in that matrix elements need not be stored. The user could trade calculational speed for storage if elements of the matrix are calculated on the fly. The goal of this study is to compare the parallel performance of Monte Carlo linear solvers to that of a more traditional parallelized linear solver. The authors observe the linear speedup that they expect from the Monte Carlo algorithm, given that there is no domain decomposition to cause significant communication overhead. Overall, PETSc outperforms the Monte Carlo solver for the test problem. The PETSc parallel performance improves with larger numbers of unknowns for a given number of processors. Parallel performance of the Monte Carlo technique is independent of the size of the matrix and the number of processes. They are investigating modifications to the scheme to accommodate matrix problems with positive off-diagonal elements. They are also currently coding an on-the-fly version of the algorithm to investigate the solution of very large linear systems
Conjugated Polymers and Oligomers: Structural and Soft Matter Aspects
DEFF Research Database (Denmark)
This book identifies modern topics and current trends of structural and soft matter aspects of conjugated polymers and oligomers. Each chapter recognizes an active research line where structural perspective dominates research and therefore the book covers fundamental aspects of persistent...... conjugated polymer backbone, water soluble conjugated polyelectrolytes and surfactants, conjugated molecules and biomolecules and DNA and the advanced use of synchrotron radiation and electron microscopy to find out structural details in conjugated molecule films and devices as well as under ambient...... and extreme conditions....
Radiation forces in the discrete dipole approximation
Hoekstra, A.G.; Frijlink, M.O.; Waters, L.B.F.M.; Sloot, P.M.A.
2001-01-01
The theory of the discrete-dipole approximation (DDA) for light scattering is extended to allow for the calculation of radiation forces on each dipole in the DDA model. Starting with the theory of Draine and Weingartner [Astrophys. J. 470, 551 (1996)] we derive an expression for the radiation force
Discrete objects, splitting closure and connectedness | Castellini ...
African Journals Online (AJOL)
Notions of discrete and indiscrete classes with respect to a closure operator are introduced and studied. These notions are strongly related to splitting and cosplitting closure operators. By linking the above concepts, two Galois connections arise whose composition provides a third Galois connection that can be used as a ...
DISCRETE ELEMENT MODELLING OF THE COMPRESSIVE ...
African Journals Online (AJOL)
Having developed and validated a code based on the Discrete Element Method principle with physical experiments the code was used to study and predict the behaviour (parametric changes) during compression of four bulk systems of particulates with the properties of canola seed, palm kernel and soyabean. The porosity ...
Discrete elements in structural concrete design
Blaauwendraad, J.; Hoogenboom, P.C.J.
1997-01-01
In the sixties Prof. J. Witteveen introduced a discrete model for the elastic analysis of slabs (Heron 1966). This article presents a similar approach for the design of reinforced concrete walls and deep beams, with holes or otherwise. The model – which is called stringer-panel model – combines the
Discretization Based on Entropy and Multiple Scanning
Directory of Open Access Journals (Sweden)
Jerzy W. Grzymala-Busse
2013-04-01
Full Text Available In this paper we present entropy driven methodology for discretization. Recently, the original entropy based discretization was enhanced by including two options of selecting the best numerical attribute. In one option, Dominant Attribute, an attribute with the smallest conditional entropy of the concept given the attribute is selected for discretization and then the best cut point is determined. In the second option, Multiple Scanning, all attributes are scanned a number of times, and at the same time the best cut points are selected for all attributes. The results of experiments on 17 benchmark data sets, including large data sets, with 175 attributes or 25,931 cases, are presented. For comparison, the results of experiments on the same data sets using the global versions of well-known discretization methods of Equal Interval Width and Equal Frequency per Interval are also included. The entropy driven technique enhanced both of these methods by converting them into globalized methods. Results of our experiments show that the Multiple Scanning methodology is significantly better than both: Dominant Attribute and the better results of Globalized Equal Interval Width and Equal Frequency per Interval methods (using two-tailed test and 0.01 level of significance.
Discrete-Time Systems -RE-SONANCEI
Indian Academy of Sciences (India)
systems, robots, space applications, farming, biotech- nology and even medicine. The disciplines of continuous-time and discrete-time sig- nals and systems have become increasingly entwined. Without any doubt, it is advantageous to process conti- nuous-time signals by sampling them. The computer control system for a ...
Electroless plating apparatus for discrete microsized particles
International Nuclear Information System (INIS)
Mayer, A.
1978-01-01
Method and apparatus are disclosed for producing very uniform coatings of a desired material on discrete microsized particles by electroless techniques. Agglomeration or bridging of the particles during the deposition process is prevented by imparting a sufficiently random motion to the particles that they are not in contact with each other for a time sufficient for such to occur
Discrete structures in F-theory compactifications
Energy Technology Data Exchange (ETDEWEB)
Till, Oskar
2016-05-04
In this thesis we study global properties of F-theory compactifications on elliptically and genus-one fibered Calabi-Yau varieties. This is motivated by phenomenological considerations as well as by the need for a deeper understanding of the set of consistent F-theory vacua. The global geometric features arise from discrete and arithmetic structures in the torus fiber and can be studied in detail for fibrations over generic bases. In the case of elliptic fibrations we study the role of the torsion subgroup of the Mordell-Weil group of sections in four dimensional compactifications. We show how the existence of a torsional section restricts the admissible matter representations in the theory. This is shown to be equivalent to inducing a non-trivial fundamental group of the gauge group. Compactifying F-theory on genus-one fibrations with multisections gives rise to discrete selection rules. In field theory the discrete symmetry is a broken U(1) symmetry. In the geometry the higgsing corresponds to a conifold transition. We explain in detail the origin of the discrete symmetry from two different M-theory phases and put the result into the context of torsion homology. Finally we systematically construct consistent gauge fluxes on genus-one fibrations and show that these induce an anomaly free chiral spectrum.
Discrete control of resonant wave energy devices.
Clément, A H; Babarit, A
2012-01-28
Aiming at amplifying the energy productive motion of wave energy converters (WECs) in response to irregular sea waves, the strategies of discrete control presented here feature some major advantages over continuous control, which is known to require, for optimal operation, a bidirectional power take-off able to re-inject energy into the WEC system during parts of the oscillation cycles. Three different discrete control strategies are described: latching control, declutching control and the combination of both, which we term latched-operating-declutched control. It is shown that any of these methods can be applied with great benefit, not only to mono-resonant WEC oscillators, but also to bi-resonant and multi-resonant systems. For some of these applications, it is shown how these three discrete control strategies can be optimally defined, either by analytical solution for regular waves, or numerically, by applying the optimal command theory in irregular waves. Applied to a model of a seven degree-of-freedom system (the SEAREV WEC) to estimate its annual production on several production sites, the most efficient of these discrete control strategies was shown to double the energy production, regardless of the resource level of the site, which may be considered as a real breakthrough, rather than a marginal improvement.
About Multi-Heston SDE Discretization
Directory of Open Access Journals (Sweden)
Tiberiu Socaciu
2013-07-01
Full Text Available Abstract: in this paper we show how can estimate a financial derivative based on a support if assume for the support a Multi-Heston model.Keywords: Euler Maruyama discretization method, Monte Carlo simulation, Heston model, Double-Heston model, Multi-Heston model.
Conservation of wave action under multisymplectic discretizations
J.E. Frank (Jason)
2006-01-01
textabstractIn this paper we discuss the conservation of wave action under numerical discretization by variational and multisymplectic methods. Both the general wave action conservation defined with respect to a smooth, periodic, one-parameter ensemble of flow realizations and the specific wave
Neutrino mass and mixing with discrete symmetry
King, Stephen F.; Luhn, Christoph
2013-05-01
This is a review paper about neutrino mass and mixing and flavour model building strategies based on discrete family symmetry. After a pedagogical introduction and overview of the whole of neutrino physics, we focus on the PMNS mixing matrix and the latest global fits following the Daya Bay and RENO experiments which measure the reactor angle. We then describe the simple bimaximal, tri-bimaximal and golden ratio patterns of lepton mixing and the deviations required for a non-zero reactor angle, with solar or atmospheric mixing sum rules resulting from charged lepton corrections or residual trimaximal mixing. The different types of see-saw mechanism are then reviewed as well as the sequential dominance mechanism. We then give a mini-review of finite group theory, which may be used as a discrete family symmetry broken by flavons either completely, or with different subgroups preserved in the neutrino and charged lepton sectors. These two approaches are then reviewed in detail in separate chapters including mechanisms for flavon vacuum alignment and different model building strategies that have been proposed to generate the reactor angle. We then briefly review grand unified theories (GUTs) and how they may be combined with discrete family symmetry to describe all quark and lepton masses and mixing. Finally, we discuss three model examples which combine an SU(5) GUT with the discrete family symmetries A4, S4 and Δ(96).
Enriched vibrational resonance in certain discrete systems
Indian Academy of Sciences (India)
We wish to report the occurrence of vibrational resonance in certain discrete systems like sine square map and sine circle map, in a unique fashion, comprising of multiple resonant peaks which pave the way for enrichment. As the systems of our choice are capable of exhibiting vibrational resonance behaviour unlike the ...
Discrete-time rewards model-checked
Larsen, K.G.; Andova, S.; Niebert, Peter; Hermanns, H.; Katoen, Joost P.
2003-01-01
This paper presents a model-checking approach for analyzing discrete-time Markov reward models. For this purpose, the temporal logic probabilistic CTL is extended with reward constraints. This allows to formulate complex measures – involving expected as well as accumulated rewards – in a precise and
Discrete dispersion models and their Tweedie asymptotics
DEFF Research Database (Denmark)
Jørgensen, Bent; Kokonendji, Célestin C.
2016-01-01
The paper introduce a class of two-parameter discrete dispersion models, obtained by combining convolution with a factorial tilting operation, similar to exponential dispersion models which combine convolution and exponential tilting. The equidispersed Poisson model has a special place in this ap......The paper introduce a class of two-parameter discrete dispersion models, obtained by combining convolution with a factorial tilting operation, similar to exponential dispersion models which combine convolution and exponential tilting. The equidispersed Poisson model has a special place...... in this approach, whereas several overdispersed discrete distributions, such as the Neyman Type A, Pólya-Aeppli, negative binomial and Poisson-inverse Gaussian, turn out to be Poisson-Tweedie factorial dispersion models with power dispersion functions, analogous to ordinary Tweedie exponential dispersion models...... with power variance functions. Using the factorial cumulant generating function as tool, we introduce a dilation operation as a discrete analogue of scaling, generalizing binomial thinning. The Poisson-Tweedie factorial dispersion models are closed under dilation, which in turn leads to a Poisson...
Geometric phases in discrete dynamical systems
Energy Technology Data Exchange (ETDEWEB)
Cartwright, Julyan H.E., E-mail: julyan.cartwright@csic.es [Instituto Andaluz de Ciencias de la Tierra, CSIC–Universidad de Granada, E-18100 Armilla, Granada (Spain); Instituto Carlos I de Física Teórica y Computacional, Universidad de Granada, E-18071 Granada (Spain); Piro, Nicolas, E-mail: nicolas.piro@epfl.ch [École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland); Piro, Oreste, E-mail: piro@imedea.uib-csic.es [Departamento de Física, Universitat de les Illes Balears, E-07122 Palma de Mallorca (Spain); Tuval, Idan, E-mail: ituval@imedea.uib-csic.es [Mediterranean Institute for Advanced Studies, CSIC–Universitat de les Illes Balears, E-07190 Mallorca (Spain)
2016-10-14
In order to study the behaviour of discrete dynamical systems under adiabatic cyclic variations of their parameters, we consider discrete versions of adiabatically-rotated rotators. Parallelling the studies in continuous systems, we generalize the concept of geometric phase to discrete dynamics and investigate its presence in these rotators. For the rotated sine circle map, we demonstrate an analytical relationship between the geometric phase and the rotation number of the system. For the discrete version of the rotated rotator considered by Berry, the rotated standard map, we further explore this connection as well as the role of the geometric phase at the onset of chaos. Further into the chaotic regime, we show that the geometric phase is also related to the diffusive behaviour of the dynamical variables and the Lyapunov exponent. - Highlights: • We extend the concept of geometric phase to maps. • For the rotated sine circle map, we demonstrate an analytical relationship between the geometric phase and the rotation number. • For the rotated standard map, we explore the role of the geometric phase at the onset of chaos. • We show that the geometric phase is related to the diffusive behaviour of the dynamical variables and the Lyapunov exponent.
A Note on Discrete Mathematics and Calculus.
O'Reilly, Thomas J.
1987-01-01
Much of the current literature on the topic of discrete mathematics and calculus during the first two years of an undergraduate mathematics curriculum is cited. A relationship between the recursive integration formulas and recursively defined polynomials is described. A Pascal program is included. (Author/RH)
Applied Behavior Analysis: Beyond Discrete Trial Teaching
Steege, Mark W.; Mace, F. Charles; Perry, Lora; Longenecker, Harold
2007-01-01
We discuss the problem of autism-specific special education programs representing themselves as Applied Behavior Analysis (ABA) programs when the only ABA intervention employed is Discrete Trial Teaching (DTT), and often for limited portions of the school day. Although DTT has many advantages to recommend its use, it is not well suited to teach…
Chaos in discrete fractional difference equations
Indian Academy of Sciences (India)
2016-09-07
Sep 7, 2016 ... tions in the mathematical modelling of real-world phenomena with memory effects. In the present paper, the chaotic behaviour of ... tives allow us to deal comfortably with memory effects in dynamical systems [2]. Discrete ..... House, Reading, Connecticut, USA, 2006). [6] F Mainardi, Fractional calculus and ...
Discrete groups, Mumford curves and Theta functions
Put, Marius van der
1992-01-01
A discrete group Γ given over some complete non archimedean valued field defines a curve X. The theta functions for Γ provide an analytic construction for the Jacobian variety of X. A theory of theta functions is developed with the help of currents on trees and graphs and the cohomology for Γ. In
Fair value accounting and managerial discretion
Byrne, A.; Clacher, I.; Hillier, D.; Hodgson, A.
2008-01-01
We analyse the extent to which managers exercise discretion under fair value accounting and the value relevance of these disclosures. Utilising a sample of firms that apply the UK fair value pension accounting standard, (FRS-17), we examine the main determinants of the assumptions managers use to
Discrete variable representation for singular Hamiltonians
DEFF Research Database (Denmark)
Schneider, B. I.; Nygaard, Nicolai
2004-01-01
We discuss the application of the discrete variable representation (DVR) to Schrodinger problems which involve singular Hamiltonians. Unlike recent authors who invoke transformations to rid the eigenvalue equation of singularities at the cost of added complexity, we show that an approach based...
Constructing an automorphism with discrete spectrum | Isere ...
African Journals Online (AJOL)
This work is a desire to construct an automorphism with discrete spectrum using a numerical example. We briefly discuss how some of the definitions and theorems about its behaviour can be implemented and verified numerically. While it is not intended as a complete introduction to measure theory, only the definitions ...
Discrete Mathematics Course Supported by CAS MATHEMATICA
Ivanov, O. A.; Ivanova, V. V.; Saltan, A. A.
2017-01-01
In this paper, we discuss examples of assignments for a course in discrete mathematics for undergraduate students majoring in business informatics. We consider several problems with computer-based solutions and discuss general strategies for using computers in teaching mathematics and its applications. In order to evaluate the effectiveness of our…
Cuspidal discrete series for projective hyperbolic spaces
DEFF Research Database (Denmark)
Andersen, Nils Byrial; Flensted-Jensen, Mogens
2013-01-01
Abstract. We have in [1] proposed a definition of cusp forms on semisimple symmetric spaces G/H, involving the notion of a Radon transform and a related Abel transform. For the real non-Riemannian hyperbolic spaces, we showed that there exists an infinite number of cuspidal discrete series, and a...
The Pairing Matrix in Discrete Electromagnetism On the Geometry of Discrete de Rham Currents
Auchmann, B
2007-01-01
We introduce pairing matrices on simplicial cell complexes in discrete electromagnetism as a means to avoid the explicit construction of a topologically dual complex. Interestingly, the Finite Element Method with first-order Whitney elements â when it is looked upon from a cell-method perspective â features pairing matrices and thus an implicitly defined dual mesh. We show that the pairing matrix can be used to construct discrete energy products. In this exercise we find that different formalisms lead to equivalent matrix representations. Discrete de Rham currents are an elegant way to subsume these geometrically equivalent but formally distinct ways of defining energy-products.
International Nuclear Information System (INIS)
Feng Baofeng; Maruno, Ken-ichi; Inoguchi, Jun-ichi; Kajiwara, Kenji; Ohta, Yasuhiro
2011-01-01
We consider integrable discretizations of some soliton equations associated with the motions of plane curves: the Wadati-Konno-Ichikawa elastic beam equation, the complex Dym equation and the short pulse equation. They are related to the modified KdV or the sine-Gordon equations by the hodograph transformations. Based on the observation that the hodograph transformations are regarded as the Euler-Lagrange transformations of the curve motions, we construct the discrete analogues of the hodograph transformations, which yield integrable discretizations of those soliton equations. (paper)
Infant differential behavioral responding to discrete emotions.
Walle, Eric A; Reschke, Peter J; Camras, Linda A; Campos, Joseph J
2017-10-01
Emotional communication regulates the behaviors of social partners. Research on individuals' responding to others' emotions typically compares responses to a single negative emotion compared with responses to a neutral or positive emotion. Furthermore, coding of such responses routinely measure surface level features of the behavior (e.g., approach vs. avoidance) rather than its underlying function (e.g., the goal of the approach or avoidant behavior). This investigation examined infants' responding to others' emotional displays across 5 discrete emotions: joy, sadness, fear, anger, and disgust. Specifically, 16-, 19-, and 24-month-old infants observed an adult communicate a discrete emotion toward a stimulus during a naturalistic interaction. Infants' responses were coded to capture the function of their behaviors (e.g., exploration, prosocial behavior, and security seeking). The results revealed a number of instances indicating that infants use different functional behaviors in response to discrete emotions. Differences in behaviors across emotions were clearest in the 24-month-old infants, though younger infants also demonstrated some differential use of behaviors in response to discrete emotions. This is the first comprehensive study to identify differences in how infants respond with goal-directed behaviors to discrete emotions. Additionally, the inclusion of a function-based coding scheme and interpersonal paradigms may be informative for future emotion research with children and adults. Possible developmental accounts for the observed behaviors and the benefits of coding techniques emphasizing the function of social behavior over their form are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
Côrtes, A.M.A.
2015-02-20
The recently introduced divergence-conforming B-spline discretizations allow the construction of smooth discrete velocity–pressure pairs for viscous incompressible flows that are at the same time inf-sup stable and pointwise divergence-free. When applied to discretized Stokes equations, these spaces generate a symmetric and indefinite saddle-point linear system. Krylov subspace methods are usually the most efficient procedures to solve such systems. One of such methods, for symmetric systems, is the Minimum Residual Method (MINRES). However, the efficiency and robustness of Krylov subspace methods is closely tied to appropriate preconditioning strategies. For the discrete Stokes system, in particular, block-diagonal strategies provide efficient preconditioners. In this article, we compare the performance of block-diagonal preconditioners for several block choices. We verify how the eigenvalue clustering promoted by the preconditioning strategies affects MINRES convergence. We also compare the number of iterations and wall-clock timings. We conclude that among the building blocks we tested, the strategy with relaxed inner conjugate gradients preconditioned with incomplete Cholesky provided the best results.
Joshi, Deepti; Soni, R. K.
2015-05-01
Pure gold and silver nanoparticle (NP) generation and their conjugation with protein S-ovalbumin using in situ conjugation process have been reported. The in situ conjugation involves nanosecond pulse laser ablation of pure metal target in the protein S-ovalbumin solution. Transmission electron microscopy (TEM) and UV-Visible absorption results show decrease in mean NP size along with narrow particle size distribution on ablation in S-ovalbumin solution as compared to ablation in water for both Au and Ag NPs. Also, the NP size reduction was found to be dependent on the concentration of S-ovalbumin. For AuNPs, spherical NPs of mean size 4 nm with particle size distribution 2-6 nm were obtained at 300 nM S-ovalbumin concentration. Further, it has been observed that the resultant in situ-conjugated colloid gold and silver NP solutions were quite stable even in the presence of NaCl at physiological salt concentration (0.15 M). On post-laser irradiation (532 nm, 15 mJ) for 20 min, 9 nm red shift in surface plasmon resonance peak (SPR), along with increased broadening towards longer wavelength, was observed in the AuNPs-S-ovalbumin sample. Further increase in the time of irradiation showed shift in AuNPs-S-ovalbumin SPR towards lower wavelength. On laser irradiation (532 nm, 15 mJ) for 20 min, no significant change was observed in the line shape of the plasmon absorption band of the AgNPs-S-ovalbumin conjugate. FTIR spectra revealed that S-ovalbumin peptide backbone and secondary structure remain unchanged on laser irradiation during in situ conjugation process. Thus, integrity of S-ovalbumin does not get affected, and no degradation of S-ovalbumin takes place on laser-induced in situ conjugation. Raman results confirm that both Au and Ag NPs interact with S-ovalbumin via thiol-bearing cysteine residues of the disulfide bond.
Complex dynamics of a delayed discrete neural network of two nonidentical neurons
International Nuclear Information System (INIS)
Chen, Yuanlong; Huang, Tingwen; Huang, Yu
2014-01-01
In this paper, we discover that a delayed discrete Hopfield neural network of two nonidentical neurons with self-connections and no self-connections can demonstrate chaotic behaviors. To this end, we first transform the model, by a novel way, into an equivalent system which has some interesting properties. Then, we identify the chaotic invariant set for this system and show that the dynamics of this system within this set is topologically conjugate to the dynamics of the full shift map with two symbols. This confirms chaos in the sense of Devaney. Our main results generalize the relevant results of Huang and Zou [J. Nonlinear Sci. 15, 291–303 (2005)], Kaslik and Balint [J. Nonlinear Sci. 18, 415–432 (2008)] and Chen et al. [Sci. China Math. 56(9), 1869–1878 (2013)]. We also give some numeric simulations to verify our theoretical results
Complex dynamics of a delayed discrete neural network of two nonidentical neurons
Chen, Yuanlong; Huang, Tingwen; Huang, Yu
2014-03-01
In this paper, we discover that a delayed discrete Hopfield neural network of two nonidentical neurons with self-connections and no self-connections can demonstrate chaotic behaviors. To this end, we first transform the model, by a novel way, into an equivalent system which has some interesting properties. Then, we identify the chaotic invariant set for this system and show that the dynamics of this system within this set is topologically conjugate to the dynamics of the full shift map with two symbols. This confirms chaos in the sense of Devaney. Our main results generalize the relevant results of Huang and Zou [J. Nonlinear Sci. 15, 291-303 (2005)], Kaslik and Balint [J. Nonlinear Sci. 18, 415-432 (2008)] and Chen et al. [Sci. China Math. 56(9), 1869-1878 (2013)]. We also give some numeric simulations to verify our theoretical results.
Complex dynamics of a delayed discrete neural network of two nonidentical neurons
Energy Technology Data Exchange (ETDEWEB)
Chen, Yuanlong [Mathematics Department, GuangDong University of Finance, Guangzhou 510521 (China); Huang, Tingwen [Mathematics Department, Texas A and M University at Qatar, P. O. Box 23874, Doha (Qatar); Huang, Yu, E-mail: stshyu@mail.sysu.edu.cn [Mathematics Department, Sun Yat-Sen University, Guangzhou 510275, People' s Republic China (China)
2014-03-15
In this paper, we discover that a delayed discrete Hopfield neural network of two nonidentical neurons with self-connections and no self-connections can demonstrate chaotic behaviors. To this end, we first transform the model, by a novel way, into an equivalent system which has some interesting properties. Then, we identify the chaotic invariant set for this system and show that the dynamics of this system within this set is topologically conjugate to the dynamics of the full shift map with two symbols. This confirms chaos in the sense of Devaney. Our main results generalize the relevant results of Huang and Zou [J. Nonlinear Sci. 15, 291–303 (2005)], Kaslik and Balint [J. Nonlinear Sci. 18, 415–432 (2008)] and Chen et al. [Sci. China Math. 56(9), 1869–1878 (2013)]. We also give some numeric simulations to verify our theoretical results.
General classes of double phase conjugation.
Sternklar, S
1995-02-01
The double phase-conjugate mirror (DPCM) is a stimulated four-wave mixing effect, mediated by either a chi(3) mechanism or a photorefractive effect. The type of grating that operates in the DPCM can be a transmission or reflection grating, depending on the wave-mixing configuration. Any combination of nonlinearity and grating geometry is possible, so that four general DPCM classes emerge. An analytic solution of the last unsolved class, the photorefractive reflection DPCM, is presented. With these results, general observations concerning the four categories of double phase conjugation are made. An important conclusion is that the type of grating geometry and its associated boundary conditions dictate many of the basic features of the DPCM, regardless of the nonlinearity involved.
Stochastic Spectral and Conjugate Descent Methods
Kovalev, Dmitry
2018-02-11
The state-of-the-art methods for solving optimization problems in big dimensions are variants of randomized coordinate descent (RCD). In this paper we introduce a fundamentally new type of acceleration strategy for RCD based on the augmentation of the set of coordinate directions by a few spectral or conjugate directions. As we increase the number of extra directions to be sampled from, the rate of the method improves, and interpolates between the linear rate of RCD and a linear rate independent of the condition number. We develop and analyze also inexact variants of these methods where the spectral and conjugate directions are allowed to be approximate only. We motivate the above development by proving several negative results which highlight the limitations of RCD with importance sampling.
Antibody conjugate radioimmunotherapy of superficial bladder cancer
International Nuclear Information System (INIS)
Perkins, Alan; Hopper, Melanie; Murray, Andrea; Frier, Malcolm; Bishop, Mike
2002-01-01
The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C 595 (gG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radio immuno conjugates of the C 595 antibody have been produced with high radiolabelling efficiency and immuno reactivity using Tc-99 m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun. (author)
Towards an integrated model of bacterial conjugation.
Cabezón, Elena; Ripoll-Rozada, Jorge; Peña, Alejandro; de la Cruz, Fernando; Arechaga, Ignacio
2015-01-01
Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV secretion system (T4SS). T4SSs are involved not only in bacterial conjugation but also in the transport of virulence factors by pathogenic bacteria. Thus, the search for specific inhibitors of different T4SS components opens a novel approach to restrict plasmid dissemination. This review highlights recent biochemical and structural findings that shed new light on the molecular mechanisms of DNA and protein transport by T4SS. Based on these data, a model for pilus biogenesis and substrate transfer in conjugative systems is proposed. This model provides a renewed view of the mechanism that might help to envisage new strategies to curb the threating expansion of antibiotic resistance. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Cancer Chemopreventive Ability of Conjugated Linolenic Acids
Directory of Open Access Journals (Sweden)
Kazuo Miyashita
2011-11-01
Full Text Available Conjugated fatty acids (CFA have received increased interest because of their beneficial effects on human health, including preventing cancer development. Conjugated linoleic acids (CLA are such CFA, and have been reviewed extensively for their multiple biological activities. In contrast to other types of CFAs including CLA that are found at low concentrations (less than 1% in natural products, conjugated linolenic acids (CLN are the only CFAs that occur in higher quantities in natural products. Some plant seeds contain a considerably high concentration of CLN (30 to 70 wt% lipid. Our research group has screened CLN from different plant seed oils to determine their cancer chemopreventive ability. This review describes the physiological functions of CLN isomers that occur in certain plant seeds. CLN are able to induce apoptosis through decrease of Bcl-2 protein in certain human cancer cell lines, increase expression of peroxisome proliferator-activated receptor (PPAR-γ, and up-regulate gene expression of p53. Findings in our preclinical animal studies have indicated that feeding with CLN resulted in inhibition of colorectal tumorigenesis through modulation of apoptosis and expression of PPARγ and p53. In this review, we summarize chemopreventive efficacy of CLN against cancer development, especially colorectal cancer.
Topuzogullari, Murat; Cakir Koc, Rabia; Dincer Isoglu, Sevil; Bagirova, Melahat; Akdeste, Zeynep; Elcicek, Serhat; Oztel, Olga N; Yesilkir Baydar, Serap; Canim Ates, Sezen; Allahverdiyev, Adil M
2013-06-03
Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to classical adjuvants. For example, polyacrylic acid (PAA) is a weak polyelectrolyte and has been used in several biomedical applications such as immunological studies, drug delivery, and enzyme immobilization. However, to our knowledge, there are no studies that document immune-stimulant properties of PAA in Leishmania infection. Therefore, we aimed to develop a potential vaccine candidate against leishmaniasis by covalently conjugating PAA with an immunologically vital molecule of lipophosphoglycan (LPG) found in Leishmania parasites. In the study, LPG and PAA were conjugated by a multi-step procedure, and final products were analyzed with GPC and MALDI-TOF MS techniques. In cytotoxicity experiments, LPG-PAA conjugates did not indicate toxic effects on L929 and J774 murine macrophage cells. We assume that LPG-PAA conjugate can be a potential vaccine candidate, and will be immunologically characterized in further studies to prove its potential.
Application of an efficient Bayesian discretization method to biomedical data
Directory of Open Access Journals (Sweden)
Gopalakrishnan Vanathi
2011-07-01
Full Text Available Abstract Background Several data mining methods require data that are discrete, and other methods often perform better with discrete data. We introduce an efficient Bayesian discretization (EBD method for optimal discretization of variables that runs efficiently on high-dimensional biomedical datasets. The EBD method consists of two components, namely, a Bayesian score to evaluate discretizations and a dynamic programming search procedure to efficiently search the space of possible discretizations. We compared the performance of EBD to Fayyad and Irani's (FI discretization method, which is commonly used for discretization. Results On 24 biomedical datasets obtained from high-throughput transcriptomic and proteomic studies, the classification performances of the C4.5 classifier and the naïve Bayes classifier were statistically significantly better when the predictor variables were discretized using EBD over FI. EBD was statistically significantly more stable to the variability of the datasets than FI. However, EBD was less robust, though not statistically significantly so, than FI and produced slightly more complex discretizations than FI. Conclusions On a range of biomedical datasets, a Bayesian discretization method (EBD yielded better classification performance and stability but was less robust than the widely used FI discretization method. The EBD discretization method is easy to implement, permits the incorporation of prior knowledge and belief, and is sufficiently fast for application to high-dimensional data.
Energy Technology Data Exchange (ETDEWEB)
Swami, Rajan; Singh, Indu [National Institute of Pharmaceutical Education & Research (NIPER), Department of Pharmaceutics (India); Kulhari, Hitesh [CSIR-Indian Institute of Chemical Technology, Medicinal Chemistry & Pharmacology Division (India); Jeengar, Manish Kumar [National Institute of Pharmaceutical Education & Research (NIPER), Departmentof Pharmacology (India); Khan, Wahid, E-mail: wahid@niperhyd.ac.in; Sistla, Ramakrishna, E-mail: sistla@iict.res.in, E-mail: rksistla@yahoo.com [National Institute of Pharmaceutical Education & Research (NIPER), Department of Pharmaceutics (India)
2015-06-15
Dendrimers which are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligand-conjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by {sup 1}HNMR and FT-IR spectroscopy. In vitro release of drug from DTX-loaded pHBA-conjugated dendrimer was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA-conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere{sup ®}). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.
Local heating of discrete droplets using magnetic porous silicon-based photonic crystals.
Park, Ji-Ho; Derfus, Austin M; Segal, Ester; Vecchio, Kenneth S; Bhatia, Sangeeta N; Sailor, Michael J
2006-06-21
This paper describes a method for local heating of discrete microliter-scale liquid droplets. The droplets are covered with magnetic porous Si microparticles, and heating is achieved by application of an external alternating electromagnetic field. The magnetic porous Si microparticles consist of two layers. The top layer contains a photonic code and it is hydrophobic, with surface-grafted dodecyl moieties. The bottom layer consists of a hydrophilic silicon oxide host layer that is infused with Fe3O4 nanoparticles. The amphiphilic microparticles spontaneously align at the interface of a water droplet immersed in mineral oil, allowing manipulation of the droplets by application of a magnetic field. Application of an oscillating magnetic field (338 kHz, 18 A rms current in a coil surrounding the experiment) generates heat in the superparamagnetic particles that can raise the temperature of the enclosed water droplet to >80 degrees C within 5 min. A simple microfluidics application is demonstrated: combining complementary DNA strands contained in separate droplets and then thermally inducing dehybridization of the conjugate. The complementary oligonucleotides were conjugated with the cyanine dye fluorophores Cy3 and Cy5 to quantify the melting/rebinding reaction by fluorescence resonance energy transfer (FRET). The magnetic porous Si microparticles were prepared as photonic crystals, containing spectral codes that allowed the identification of the droplets by reflectivity spectroscopy. The technique demonstrates the feasibility of tagging, manipulating, and heating small volumes of liquids without the use of conventional microfluidic channel and heating systems.
Carbon nanotube-enzyme conjugates for the fabrication of diagnostic biosensors
Karunwi, Olukayode Adedamola
The fabrication of multi-analyte biotransducers continues to be a major technical challenge when the length scales of the individual transducer elements are on the order of microns Generation-3 (Gen-3) biosensors and advanced enzyme biofuel cells will benefit from direct electron transfer to oxidoreductases facilitated by single-walled carbon nanotubes (SWNTs). Direct electron transfer helps to mitigate errors from the instability in oxygen tension, eliminate use of a mediator and produce a device with low operating potential close to the redox potential of the enzymes. Supramolecular conjugates of SWNT-glucose oxidase (GOx-SWNT) may be produced via ultrasonic processing. Using a Plackett-Burman experimental design to investigate the process of tip ultrasonication, conjugate formation was investigated as a function of ultrasonication times and functionalized SWNTs of various tube lengths. Supramolecular conjugates formed from shorter, -OH functionalized SWNTs using longer sonication times gave the most favored combination for forming bioactive conjugates. There has also been growing interest in the fabrication of CNT-enzyme supramolecular constructs that control the placement of SWNTs within tunneling distance of co-factors for enhanced electron transfer efficiency in generation 3 biosensors and advanced biofuel cells. These conjugate systems raise a series of questions such as: Which peptide sequences within the enzymes have high affinity for the SWNTs? And, are these high affinity sequences likely to be in the vicinity of the redox-active co-factor to allow for direct electron transfer? Phage display has recently been used to identify specific peptide sequences that have high affinity for SWNTs. Molecular dynamics simulations were performed to study the interactions of five discrete peptides with (16,0) SWNT in explicit water as well as with graphene. The end residues appear to dominate the progression of adsorption regardless of character. Sequences identified
International Nuclear Information System (INIS)
Wani, Manzoor Ahmad; Singh, Pankaj Kumar; Pandey, Rampal; Pandey, Mrituanjay D.
2016-01-01
In this work, we report a coumarin–pyrene based fluorescent probes (E)-7-(diethylamino)-3-((pyren-1-ylimino)methyl)-2H-chromen-2-one (1) and (E)-7-(diethylamino)-3-((pyren-1-ylmethylimino)methyl)-2H-chromen-2-one (2) for the selective detection of Cu 2+ ion. Receptor 1 upon binding with Cu 2+ exhibited substantial fluorescence quenching as a detection response. Probe 1 induces green fluorescence in a cell lines derived from monkey kidney tissue and subsequent quenching of fluorescence in these cells manifest that 1 can probably be used as a potential fluorescent sensor for the detection of Cu 2+ in biological samples too. However, 2 does not reveal any significant fluorescence change in presence of different metal ions. It is assumed that conjugation might be accountable for the discrete fluorescent behavior of 1 and 2.
Dimension Reduction and Discretization in Stochastic Problems by Regression Method
DEFF Research Database (Denmark)
Ditlevsen, Ove Dalager
1996-01-01
The chapter mainly deals with dimension reduction and field discretizations based directly on the concept of linear regression. Several examples of interesting applications in stochastic mechanics are also given.Keywords: Random fields discretization, Linear regression, Stochastic interpolation...
Breatherlike excitations in discrete lattices with noise and nonlinear damping
DEFF Research Database (Denmark)
Christiansen, Peter Leth; Gaididei, Yuri B.; Johansson, Magnus
1997-01-01
We discuss the stability of highly localized, ''breatherlike,'' excitations in discrete nonlinear lattices under the influence of thermal fluctuations. The particular model considered is the discrete nonlinear Schrodinger equation in the regime of high nonlinearity, where temperature effects...
Nonlinear Control and Discrete Event Systems
Meyer, George; Null, Cynthia H. (Technical Monitor)
1995-01-01
As the operation of large systems becomes ever more dependent on extensive automation, the need for an effective solution to the problem of design and validation of the underlying software becomes more critical. Large systems possesses much detailed structure, typically hierarchical, and they are hybrid. Information processing at the top of the hierarchy is by means of formal logic and sentences; on the bottom it is by means of simple scalar differential equations and functions of time; and in the middle it is by an interacting mix of nonlinear multi-axis differential equations and automata, and functions of time and discrete events. The lecture will address the overall problem as it relates to flight vehicle management, describe the middle level, and offer a design approach that is based on Differential Geometry and Discrete Event Dynamic Systems Theory.
Discrete and continuous simulation theory and practice
Bandyopadhyay, Susmita
2014-01-01
When it comes to discovering glitches inherent in complex systems-be it a railway or banking, chemical production, medical, manufacturing, or inventory control system-developing a simulation of a system can identify problems with less time, effort, and disruption than it would take to employ the original. Advantageous to both academic and industrial practitioners, Discrete and Continuous Simulation: Theory and Practice offers a detailed view of simulation that is useful in several fields of study.This text concentrates on the simulation of complex systems, covering the basics in detail and exploring the diverse aspects, including continuous event simulation and optimization with simulation. It explores the connections between discrete and continuous simulation, and applies a specific focus to simulation in the supply chain and manufacturing field. It discusses the Monte Carlo simulation, which is the basic and traditional form of simulation. It addresses future trends and technologies for simulation, with par...
Integral and discrete inequalities and their applications
Qin, Yuming
2016-01-01
This book focuses on one- and multi-dimensional linear integral and discrete Gronwall-Bellman type inequalities. It provides a useful collection and systematic presentation of known and new results, as well as many applications to differential (ODE and PDE), difference, and integral equations. With this work the author fills a gap in the literature on inequalities, offering an ideal source for researchers in these topics. The present volume is part 1 of the author’s two-volume work on inequalities. Integral and discrete inequalities are a very important tool in classical analysis and play a crucial role in establishing the well-posedness of the related equations, i.e., differential, difference and integral equations.
Discrete Spectrum Reconstruction Using Integral Approximation Algorithm.
Sizikov, Valery; Sidorov, Denis
2017-07-01
An inverse problem in spectroscopy is considered. The objective is to restore the discrete spectrum from observed spectrum data, taking into account the spectrometer's line spread function. The problem is reduced to solution of a system of linear-nonlinear equations (SLNE) with respect to intensities and frequencies of the discrete spectral lines. The SLNE is linear with respect to lines' intensities and nonlinear with respect to the lines' frequencies. The integral approximation algorithm is proposed for the solution of this SLNE. The algorithm combines solution of linear integral equations with solution of a system of linear algebraic equations and avoids nonlinear equations. Numerical examples of the application of the technique, both to synthetic and experimental spectra, demonstrate the efficacy of the proposed approach in enabling an effective enhancement of the spectrometer's resolution.
Probabilistic Discrete Mixtures Colour Texture Models
Czech Academy of Sciences Publication Activity Database
Haindl, Michal; Havlíček, Vojtěch; Grim, Jiří
2008-01-01
Roč. 2008, č. 5197 (2008), s. 675-682 ISSN 0302-9743. [Iberoamerican Congress on Pattern Recognition /13./. Havana, 09.092008-12.09.2008] R&D Projects: GA AV ČR 1ET400750407; GA MŠk 1M0572; GA ČR GA102/07/1594; GA ČR GA102/08/0593 Grant - others:GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : Discrete distribution mixtures * EM algorithm * texture modeling Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2008/RO/haindl-havlicek-grim-probabilistic%20discrete%20mixtures%20colour%20texture%20models.pdf
Discrete event systems diagnosis and diagnosability
Sayed-Mouchaweh, Moamar
2014-01-01
Discrete Event Systems: Diagnosis and Diagnosability addresses the problem of fault diagnosis of Discrete Event Systems (DES). This book provides the basic techniques and approaches necessary for the design of an efficient fault diagnosis system for a wide range of modern engineering applications. The different techniques and approaches are classified according to several criteria such as: modeling tools (Automata, Petri nets) that is used to construct the model; the information (qualitative based on events occurrences and/or states outputs, quantitative based on signal processing and data analysis) that is needed to analyze and achieve the diagnosis; the decision structure (centralized, decentralized) that is required to achieve the diagnosis. The goal of this classification is to select the efficient method to achieve the fault diagnosis according to the application constraints. This book focuses on the centralized and decentralized event based diagnosis approaches using formal language and automata as mode...
Gauged discrete symmetries and proton stability
International Nuclear Information System (INIS)
Mohapatra, Rabindra N.; Ratz, Michael
2007-01-01
We discuss the results of a search for anomaly-free Abelian Z N discrete symmetries that lead to automatic R-parity conservation and prevent dangerous higher-dimensional proton decay operators in simple extensions of minimal supersymmetric extension of the standard model based on the left-right symmetric group, the Pati-Salam group and SO(10). We require that the superpotential for the models have enough structures to be able to give correct symmetry breaking to minimal supersymmetric extension of the standard model and potentially realistic fermion masses. We find viable models in each of the extensions, and for all the cases, anomaly freedom of the discrete symmetry restricts the number of generations
Finite Volumes Discretization of Topology Optimization Problems
DEFF Research Database (Denmark)
Evgrafov, Anton; Gregersen, Misha Marie; Sørensen, Mads Peter
, FVMs represent a standard method of discretization within engineering communities dealing with computational uid dy- namics, transport, and convection-reaction problems. Among various avours of FVMs, cell based approaches, where all variables are associated only with cell centers, are particularly...... computations is done using nite element methods (FEMs). Despite some limited recent eorts [1, 2], we have only started to develop our understanding of the interplay between the control in the coecients and FVMs. Recent advances in discrete functional analysis allow us to analyze convergence of FVM...... of the induced parametrization of the design space that allows optimization algorithms to eciently explore it, and the ease of integration with existing computational codes in a variety of application areas, the simplicity and eciency of sensitivity analyses|all stemming from the use of the same grid throughout...
Testing Preference Axioms in Discrete Choice experiments
DEFF Research Database (Denmark)
Hougaard, Jens Leth; Østerdal, Lars Peter; Tjur, Tue
Recent studies have tested the preference axioms of completeness and transitivity, and have detected other preference phenomena such as unstability, learning- and tiredness effects, ordering effects and dominance, in stated preference discrete choice experiments. However, it has not been explicitly...... addressed in these studies which preference models are actually being tested, and the connection between the statistical tests performed and the relevant underlying models of respondent behavior has not been explored further. This paper tries to fill that gap. We specifically analyze the meaning and role...... of the preference axioms and other preference phenomena in the context of stated preference discrete choice experiments, and examine whether or how these can be subject to meaningful (statistical) tests...
PHASE CHAOS IN THE DISCRETE KURAMOTO MODEL
DEFF Research Database (Denmark)
Maistrenko, V.; Vasylenko, A.; Maistrenko, Y.
2010-01-01
The paper describes the appearance of a novel, high-dimensional chaotic regime, called phase chaos, in a time-discrete Kuramoto model of globally coupled phase oscillators. This type of chaos is observed at small and intermediate values of the coupling strength. It arises from the nonlinear...... interaction among the oscillators, while the individual oscillators behave periodically when left uncoupled. For the four-dimensional time-discrete Kuramoto model, we outline the region of phase chaos in the parameter plane and determine the regions where phase chaos coexists with different periodic...... attractors. We also study the subcritical frequency-splitting bifurcation at the onset of desynchronization and demonstrate that the transition to phase chaos takes place via a torus destruction process....
Discrete approach to complex planar geometries
International Nuclear Information System (INIS)
Cupini, E.; De Matteis, A.
1974-01-01
Planar regions in Monte Carlo transport problems have been represented by a finite set of points with a corresponding region index for each. The simulation of particle free-flight reduces then to the simple operations necessary for scanning appropriate grid points to determine whether a region other than the starting one is encountered. When the complexity of the geometry is restricted to only some regions of the assembly examined, a mixed discrete-continuous philosophy may be adopted. By this approach, the lattice of a thermal reactor has been treated, discretizing only the central regions of the cell containing the fuel rods. Excellent agreement with experimental results has been obtained in the computation of cell parameters in the energy range from fission to thermalization through the 238 U resonance region. (U.S.)
Juxtaposed color halftoning relying on discrete lines.
Babaei, Vahid; Hersch, Roger D
2013-02-01
Most halftoning techniques allow screen dots to overlap. They rely on the assumption that the inks are transparent, i.e., the inks do not scatter a significant portion of the light back to the air. However, many special effect inks, such as metallic inks, iridescent inks, or pigmented inks, are not transparent. In order to create halftone images, halftone dots formed by such inks should be juxtaposed, i.e., printed side by side. We propose an efficient juxtaposed color halftoning technique for placing any desired number of colorant layers side by side without overlapping. The method uses a monochrome library of screen elements made of discrete lines with rational thicknesses. Discrete line juxtaposed color halftoning is performed efficiently by multiple accesses to the screen element library.
Geometric theory of discrete nonautonomous dynamical systems
Pötzsche, Christian
2010-01-01
Nonautonomous dynamical systems provide a mathematical framework for temporally changing phenomena, where the law of evolution varies in time due to seasonal, modulation, controlling or even random effects. Our goal is to provide an approach to the corresponding geometric theory of nonautonomous discrete dynamical systems in infinite-dimensional spaces by virtue of 2-parameter semigroups (processes). These dynamical systems are generated by implicit difference equations, which explicitly depend on time. Compactness and dissipativity conditions are provided for such problems in order to have attractors using the natural concept of pullback convergence. Concerning a necessary linear theory, our hyperbolicity concept is based on exponential dichotomies and splittings. This concept is in turn used to construct nonautonomous invariant manifolds, so-called fiber bundles, and deduce linearization theorems. The results are illustrated using temporal and full discretizations of evolutionary differential equations.
Hydraulically controlled discrete sampling from open boreholes
Harte, Philip T.
2013-01-01
Groundwater sampling from open boreholes in fractured-rock aquifers is particularly challenging because of mixing and dilution of fluid within the borehole from multiple fractures. This note presents an alternative to traditional sampling in open boreholes with packer assemblies. The alternative system called ZONFLO (zonal flow) is based on hydraulic control of borehole flow conditions. Fluid from discrete fractures zones are hydraulically isolated allowing for the collection of representative samples. In rough-faced open boreholes and formations with less competent rock, hydraulic containment may offer an attractive alternative to physical containment with packers. Preliminary test results indicate a discrete zone can be effectively hydraulically isolated from other zones within a borehole for the purpose of groundwater sampling using this new method.
Discrete PID Tuning Using Artificial Intelligence Techniques
Directory of Open Access Journals (Sweden)
Petr DOLEŽEL
2009-06-01
Full Text Available PID controllers are widely used in industry these days due to their useful properties such as simple tuning or robustness. While they are applicable to many control problems, they can perform poorly in some applications. Highly nonlinear system control with constrained manipulated variable can be mentioned as an example. The point of the paper is to string together convenient qualities of conventional PID control and progressive techniques based on Artificial Intelligence. Proposed control method should deal with even highly nonlinear systems. To be more specific, there is described new method of discrete PID controller tuning in this paper. This method tunes discrete PID controller parameters online through the use of genetic algorithm and neural model of controlled system in order to control successfully even highly nonlinear systems. After method description and some discussion, there is performed control simulation and comparison to one chosen conventional control method.
Data bases and discrete event simulation
Boubetra, Abdelhak; Belouadah, Hocine; Mouhoub, Nassreddine
2007-01-01
This paper is an attempt to define how a specific data structure might be used to store, in a persistent manner, temporal information during a computer simulation. In particular, it considers the sort of temporal information generated during a discrete event simulation of a system to which a relational data base exists and considers the demands this data makes on data base design. Facultad de Informática
Discrete time analysis of a repairable machine
Alfa, Attahiru Sule; Castro, I. T.
2002-01-01
We consider, in discrete time, a single machine system that operates for a period of time represented by a general distribution. This machine is subject to failures during operations and the occurrence of these failures depends on how many times the machine has previously failed. Some failures are repairable and the repair times may or may not depend on the number of times the machine was previously repaired. Repair times also have a general distribution. The operating times...
Texture modelling by discrete distribution mixtures
Czech Academy of Sciences Publication Activity Database
Grim, Jiří; Haindl, Michal
2003-01-01
Roč. 41, 3-4 (2003), s. 603-615 ISSN 0167-9473 R&D Projects: GA ČR GA102/00/0030; GA AV ČR KSK1019101 Institutional research plan: CEZ:AV0Z1075907 Keywords : discrete distribution mixtures * EM algorithm * texture modelling Subject RIV: JC - Computer Hardware ; Software Impact factor: 0.711, year: 2003
Exponential-modified discrete Lindley distribution.
Yilmaz, Mehmet; Hameldarbandi, Monireh; Acik Kemaloglu, Sibel
2016-01-01
In this study, we have considered a series system composed of stochastically independent M-component where M is a random variable having the zero truncated modified discrete Lindley distribution. This distribution is newly introduced by transforming on original parameter. The properties of the distribution of the lifetime of above system have been examined under the given circumstances and also parameters of this new lifetime distribution are estimated by using moments, maximum likelihood and EM-algorithm.
Discrete Alfven waves in the TORTUS tokamak
International Nuclear Information System (INIS)
Amagishi, Y.; Ballico, M.J.; Cross, R.C.; Donnely, I.J.
1989-01-01
Discrete Alfven Waves (DAWs) have been observed as antenna resistance peaks and as enhanced edge fields in the TORTUS tokamak during Alfven wave heating experiments. A kinetic theory code has been used to calculate the antenna loading and the structure of the DAW fields for a range of plasma current and density profiles. There is fair agreement between the measured and predicted amplitude of the DAW fields in the plasma edge when both are normalized to the same antenna power
Quantifying Discretization Effects on Brain Trauma Simulations
2016-01-01
toward equilibrium from the inflection point (displaced 15.7° from equilibrium). One immediately visible result is that the pressure, stress , and strain...are 10.1° from equilibrium, 0.9° back toward equilibrium from the inflection point (displaced 59.1° from equilibrium), and 44.3° back toward...equilibrium from the inflection point (displaced 15.7° from equilibrium). ...........................................10 Fig. 8 Effect of discretization
Discrete Tolerance Allocation for Product Families
2011-01-01
Abstract This paper extends earlier research on the discrete tolerance allocation problem in order to optimize an entire product family simultaneously. This methodology enables top-down tolerancing approach where requirements on assembly level on products within a family are allocated to single part requirements. The proposed solution has been implemented as an interface with an optimization algorithm coupled with a variation simulation software. The paper also consists of an exten...
A variational synthesis nodal discrete ordinates method
International Nuclear Information System (INIS)
Favorite, J.A.; Stacey, W.M.
1999-01-01
A self-consistent nodal approximation method for computing discrete ordinates neutron flux distributions has been developed from a variational functional for neutron transport theory. The advantage of the new nodal method formulation is that it is self-consistent in its definition of the homogenized nodal parameters, the construction of the global nodal equations, and the reconstruction of the detailed flux distribution. The efficacy of the method is demonstrated by two-dimensional test problems
Bounded solutions and wavefronts for discrete dynamics
Czech Academy of Sciences Publication Activity Database
Malaguti, L.; Řehák, Pavel; Taddei, V.
2004-01-01
Roč. 47, - (2004), s. 1079-1094 ISSN 0898-1221 R&D Projects: GA ČR GA201/01/0079; GA ČR GP201/01/P041 Institutional research plan: CEZ:AV0Z1019905 Keywords : nonlinear difference equation * bounded solution * discrete travelling waves Subject RIV: BA - General Mathematics Impact factor: 0.431, year: 2004
Hyponormal differential operators with discrete spectrum
Directory of Open Access Journals (Sweden)
Zameddin I. Ismailov
2010-01-01
Full Text Available In this work, we first describe all the maximal hyponormal extensions of a minimal operator generated by a linear differential-operator expression of the first-order in the Hilbert space of vector-functions in a finite interval. Next, we investigate the discreteness of the spectrum and the asymptotical behavior of the modules of the eigenvalues for these maximal hyponormal extensions.
Inferring gene networks from discrete expression data
Zhang, L.
2013-07-18
The modeling of gene networks from transcriptional expression data is an important tool in biomedical research to reveal signaling pathways and to identify treatment targets. Current gene network modeling is primarily based on the use of Gaussian graphical models applied to continuous data, which give a closedformmarginal likelihood. In this paper,we extend network modeling to discrete data, specifically data from serial analysis of gene expression, and RNA-sequencing experiments, both of which generate counts of mRNAtranscripts in cell samples.We propose a generalized linear model to fit the discrete gene expression data and assume that the log ratios of the mean expression levels follow a Gaussian distribution.We restrict the gene network structures to decomposable graphs and derive the graphs by selecting the covariance matrix of the Gaussian distribution with the hyper-inverse Wishart priors. Furthermore, we incorporate prior network models based on gene ontology information, which avails existing biological information on the genes of interest. We conduct simulation studies to examine the performance of our discrete graphical model and apply the method to two real datasets for gene network inference. © The Author 2013. Published by Oxford University Press. All rights reserved.
An essay on discrete foundations for physics
International Nuclear Information System (INIS)
Noyes, H.P.; McGoveran, D.O.
1988-01-01
We base our theory of physics and cosmology on the five principles of finiteness, discreteness, finite computability, absolute non- uniqueness, and strict construction. Our modeling methodology starts from the current practice of physics, constructs a self-consistent representation based on the ordering operator calculus and provides rules of correspondence that allow us to test the theory by experiment. We use program universe to construct a growing collection of bit strings whose initial portions (labels) provide the quantum numbers that are conserved in the events defined by the construction. The labels are followed by content strings which are used to construct event-based finite and discrete coordinates. On general grounds such a theory has a limiting velocity, and positions and velocities do not commute. We therefore reconcile quantum mechanics with relativity at an appropriately fundamental stage in the construction. We show that events in different coordinate systems are connected by the appropriate finite and discrete version of the Lorentz transformation, that 3-momentum is conserved in events, and that this conservation law is the same as the requirement that different paths can ''interfere'' only when they differ by an integral number of deBroglie wavelengths. 38 refs., 12 figs., 3 tabs
Police investigations: discretion denied yet undeniably exercised
Belur, J.; Tilley, N.; Osrin, D.; Daruwalla, N.; Kumar, M.; Tiwari, V.
2014-01-01
Police investigations involve determining whether a crime has been committed, and if so what type of crime, who has committed it and whether there is the evidence to charge the perpetrators. Drawing on fieldwork in Delhi and Mumbai, this paper explores how police investigations unfolded in the specific context of women’s deaths by burning in India. In particular, it focuses on the use of discretion despite its denial by those exercising it. In India, there are distinctive statutes relating to women’s suspicious deaths, reflecting the widespread expectation that the bride’s family will pay a dowry to the groom’s family and the tensions to which this may on occasion give rise in the early years of a marriage. Often, there are conflicting claims influencing how the woman’s death is classified. These in turn affect police investigation. The nature and direction of police discretion in investigating women’s deaths by burning reflect in part the unique nature of the legislation and the particular sensitivities in relation to these types of death. They also highlight processes that are liable to be at work in any crime investigation. It was found that police officers exercised unacknowledged discretion at seven specific points in the investigative process, with potentially significant consequences for the achievement of just outcomes: first response, recording the victim’s ‘dying declaration’, inquest, registering of the ‘First Information Report’, collecting evidence, arrest and framing of the charges. PMID:26376482
Meshes optimized for discrete exterior calculus (DEC).
Energy Technology Data Exchange (ETDEWEB)
Mousley, Sarah C. [Univ. of Illinois, Urbana-Champaign, IL (United States); Deakin, Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Knupp, Patrick [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mitchell, Scott A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2017-12-01
We study the optimization of an energy function used by the meshing community to measure and improve mesh quality. This energy is non-traditional because it is dependent on both the primal triangulation and its dual Voronoi (power) diagram. The energy is a measure of the mesh's quality for usage in Discrete Exterior Calculus (DEC), a method for numerically solving PDEs. In DEC, the PDE domain is triangulated and this mesh is used to obtain discrete approximations of the continuous operators in the PDE. The energy of a mesh gives an upper bound on the error of the discrete diagonal approximation of the Hodge star operator. In practice, one begins with an initial mesh and then makes adjustments to produce a mesh of lower energy. However, we have discovered several shortcomings in directly optimizing this energy, e.g. its non-convexity, and we show that the search for an optimized mesh may lead to mesh inversion (malformed triangles). We propose a new energy function to address some of these issues.
Quantum cosmology based on discrete Feynman paths
International Nuclear Information System (INIS)
Chew, Geoffrey F.
2002-01-01
Although the rules for interpreting local quantum theory imply discretization of process, Lorentz covariance is usually regarded as precluding time quantization. Nevertheless a time-discretized quantum representation of redshifting spatially-homogeneous universe may be based on discrete-step Feynman paths carrying causal Lorentz-invariant action--paths that not only propagate the wave function but provide a phenomenologically-promising elementary-particle Hilbert-space basis. In a model under development, local path steps are at Planck scale while, at a much larger ''wave-function scale'', global steps separate successive wave-functions. Wave-function spacetime is but a tiny fraction of path spacetime. Electromagnetic and gravitational actions are ''at a distance'' in Wheeler-Feynman sense while strong (color) and weak (isospin) actions, as well as action of particle motion, are ''local'' in a sense paralleling the action of local field theory. ''Nonmaterial'' path segments and ''trivial events'' collaborate to define energy and gravity. Photons coupled to conserved electric charge enjoy privileged model status among elementary fermions and vector bosons. Although real path parameters provide no immediate meaning for ''measurement'', the phase of the complex wave function allows significance for ''information'' accumulated through ''gentle'' electromagnetic events involving charged matter and ''soft'' photons. Through its soft-photon content the wave function is an ''information reservoir''
An essay on discrete foundations for physics
International Nuclear Information System (INIS)
Noyes, H.P.; McGoveran, D.O.
1988-07-01
We base our theory of physics and cosmology on the five principles of finiteness, discreteness, finite computability, absolute non-uniqueness, and strict construction. Our modeling methodology starts from the current practice of physics, constructs a self-consistent representation based on the ordering operator calculus and provides rules of correspondence that allow us to test the theory by experiment. We use program universe to construct a growing collection of bit strings whose initial portions (labels) provide the quantum numbers that are conserved in the events defined by the construction. The labels are followed by content strings which are used to construct event-based finite and discrete coordinates. On general grounds such a theory has a limiting velocity, and positions and velocities do not commute. We therefore reconcile quantum mechanics with relativity at an appropriately fundamental stage in the construction. We show that events in different coordinate systems are connected by the appropriate finite and discrete version of the Lorentz transformation, that 3-momentum is conserved in events, and that this conservation law is the same as the requirement that different paths can ''interfere'' only when they differ by an integral number of deBroglie wavelengths. 38 refs., 12 figs., 3 tabs
An essay on discrete foundations for physics
Energy Technology Data Exchange (ETDEWEB)
Noyes, H.P.; McGoveran, D.O.
1988-07-01
We base our theory of physics and cosmology on the five principles of finiteness, discreteness, finite computability, absolute non-uniqueness, and strict construction. Our modeling methodology starts from the current practice of physics, constructs a self-consistent representation based on the ordering operator calculus and provides rules of correspondence that allow us to test the theory by experiment. We use program universe to construct a growing collection of bit strings whose initial portions (labels) provide the quantum numbers that are conserved in the events defined by the construction. The labels are followed by content strings which are used to construct event-based finite and discrete coordinates. On general grounds such a theory has a limiting velocity, and positions and velocities do not commute. We therefore reconcile quantum mechanics with relativity at an appropriately fundamental stage in the construction. We show that events in different coordinate systems are connected by the appropriate finite and discrete version of the Lorentz transformation, that 3-momentum is conserved in events, and that this conservation law is the same as the requirement that different paths can ''interfere'' only when they differ by an integral number of deBroglie wavelengths. 38 refs., 12 figs., 3 tabs.
An essay on discrete foundations for physics
Energy Technology Data Exchange (ETDEWEB)
Noyes, H.P.; McGoveran, D.O.
1988-10-05
We base our theory of physics and cosmology on the five principles of finiteness, discreteness, finite computability, absolute non- uniqueness, and strict construction. Our modeling methodology starts from the current practice of physics, constructs a self-consistent representation based on the ordering operator calculus and provides rules of correspondence that allow us to test the theory by experiment. We use program universe to construct a growing collection of bit strings whose initial portions (labels) provide the quantum numbers that are conserved in the events defined by the construction. The labels are followed by content strings which are used to construct event-based finite and discrete coordinates. On general grounds such a theory has a limiting velocity, and positions and velocities do not commute. We therefore reconcile quantum mechanics with relativity at an appropriately fundamental stage in the construction. We show that events in different coordinate systems are connected by the appropriate finite and discrete version of the Lorentz transformation, that 3-momentum is conserved in events, and that this conservation law is the same as the requirement that different paths can ''interfere'' only when they differ by an integral number of deBroglie wavelengths. 38 refs., 12 figs., 3 tabs.
Physical models on discrete space and time
International Nuclear Information System (INIS)
Lorente, M.
1986-01-01
The idea of space and time quantum operators with a discrete spectrum has been proposed frequently since the discovery that some physical quantities exhibit measured values that are multiples of fundamental units. This paper first reviews a number of these physical models. They are: the method of finite elements proposed by Bender et al; the quantum field theory model on discrete space-time proposed by Yamamoto; the finite dimensional quantum mechanics approach proposed by Santhanam et al; the idea of space-time as lattices of n-simplices proposed by Kaplunovsky et al; and the theory of elementary processes proposed by Weizsaecker and his colleagues. The paper then presents a model proposed by the authors and based on the (n+1)-dimensional space-time lattice where fundamental entities interact among themselves 1 to 2n in order to build up a n-dimensional cubic lattice as a ground field where the physical interactions take place. The space-time coordinates are nothing more than the labelling of the ground field and take only discrete values. 11 references
Discrete dynamic modeling of cellular signaling networks.
Albert, Réka; Wang, Rui-Sheng
2009-01-01
Understanding signal transduction in cellular systems is a central issue in systems biology. Numerous experiments from different laboratories generate an abundance of individual components and causal interactions mediating environmental and developmental signals. However, for many signal transduction systems there is insufficient information on the overall structure and the molecular mechanisms involved in the signaling network. Moreover, lack of kinetic and temporal information makes it difficult to construct quantitative models of signal transduction pathways. Discrete dynamic modeling, combined with network analysis, provides an effective way to integrate fragmentary knowledge of regulatory interactions into a predictive mathematical model which is able to describe the time evolution of the system without the requirement for kinetic parameters. This chapter introduces the fundamental concepts of discrete dynamic modeling, particularly focusing on Boolean dynamic models. We describe this method step-by-step in the context of cellular signaling networks. Several variants of Boolean dynamic models including threshold Boolean networks and piecewise linear systems are also covered, followed by two examples of successful application of discrete dynamic modeling in cell biology.
Discrete phase space based on finite fields
International Nuclear Information System (INIS)
Gibbons, Kathleen S.; Hoffman, Matthew J.; Wootters, William K.
2004-01-01
The original Wigner function provides a way of representing in phase space the quantum states of systems with continuous degrees of freedom. Wigner functions have also been developed for discrete quantum systems, one popular version being defined on a 2Nx2N discrete phase space for a system with N orthogonal states. Here we investigate an alternative class of discrete Wigner functions, in which the field of real numbers that labels the axes of continuous phase space is replaced by a finite field having N elements. There exists such a field if and only if N is a power of a prime; so our formulation can be applied directly only to systems for which the state-space dimension takes such a value. Though this condition may seem limiting, we note that any quantum computer based on qubits meets the condition and can thus be accommodated within our scheme. The geometry of our NxN phase space also leads naturally to a method of constructing a complete set of N+1 mutually unbiased bases for the state space
Jadhav, Swati B; Singhal, Rekha S
2013-10-15
Two enzymes, α-amylase and glucoamylase have been individually and co-conjugated to pectin by covalent binding. Both the enzyme systems showed better thermal and pH stability over the free enzyme system with the complete retention of original activities. Mixture of individually conjugated enzymes showed lower inactivation rate constant with longer half life than the co-conjugated enzyme system. Individually conjugated enzymes showed an increase of 56.48 kJ/mole and 38.22 kJ/mole in activation energy for denaturation than the free enzymes and co-conjugated enzymes, respectively. Km as well as Vmax of individually and co-conjugated enzymes was found to be higher than the free enzymes. SDS-polyacrylamide gel electrophoresis confirmed the formation of conjugate and co-conjugate as evident by increased molecular weight. Both the enzyme systems were used for starch hydrolysis where individually conjugated enzymes showed highest release of glucose at 60 °C and pH 5.0 as compared to free and co-conjugated enzyme. Copyright © 2013 Elsevier Ltd. All rights reserved.
A Lax pair of the discrete Euler top
International Nuclear Information System (INIS)
Kimura, Kinji
2017-01-01
We proposed the discrete Euler top in 2000. In that paper, exact solutions and conserved quantities are described. However, a Lax pair of our proposed discrete Euler top is not contained. Moreover, the Lax pair is still unknown. In this paper, from a generalized eigenvalue problem, we obtain the Lax pair of the discrete Euler top. (paper)
A Variational Approach to Perturbed Discrete Anisotropic Equations
Directory of Open Access Journals (Sweden)
Amjad Salari
2016-01-01
Full Text Available We continue the study of discrete anisotropic equations and we will provide new multiplicity results of the solutions for a discrete anisotropic equation. We investigate the existence of infinitely many solutions for a perturbed discrete anisotropic boundary value problem. The approach is based on variational methods and critical point theory.
A Baecklund transformation between two integrable discrete hungry systems
International Nuclear Information System (INIS)
Fukuda, Akiko; Yamamoto, Yusaku; Iwasaki, Masashi; Ishiwata, Emiko; Nakamura, Yoshimasa
2011-01-01
The discrete hungry Toda (dhToda) equation and the discrete hungry Lotka-Volterra (dhLV) system are known as integrable discrete hungry systems. In this Letter, through finding the LR transformations associated with the dhToda equation and the dhLV system, we present a Baecklund transformation between these integrable systems.
Finite-dimensional reductions of the discrete Toda chain
Kazakova, T. G.
2004-08-01
The problem of construction of integrable boundary conditions for the discrete Toda chain is considered. The restricted chains for properly chosen closure conditions are reduced to the well-known discrete Painlevé equations dPIII, dPV, dPVI. Lax representations for these discrete Painlevé equations are found.
Discrete frequency identification using the HP 5451B Fourier analyser
International Nuclear Information System (INIS)
Holland, L.; Barry, P.
1977-01-01
The frequency analysis by the HP5451B discrete frequency Fourier analyser is studied. The advantages of cross correlation analysis to identify discrete frequencies in a background noise are discussed in conjuction with the elimination of aliasing and wraparound error. Discrete frequency identification is illustrated by a series of graphs giving the results of analysing 'electrical' and 'acoustical' white noise and sinusoidal signals [pt
Mittag-Leffler function for discrete fractional modelling
Directory of Open Access Journals (Sweden)
Guo-Cheng Wu
2016-01-01
Full Text Available From the difference equations on discrete time scales, this paper numerically investigates one discrete fractional difference equation in the Caputo delta’s sense which has an explicit solution in form of the discrete Mittag-Leffler function. The exact numerical values of the solutions are given in comparison with the truncated Mittag-Leffler function.
Process algebra with timing: Real time and discrete time
Baeten, J.C.M.; Middelburg, C.A.
1999-01-01
We present real time and discrete time versions of ACP with absolute timing and relative timing. The startingpoint is a new real time version with absolute timing, called ACPsat , featuring urgent actions and a delay operator. The discrete time versions are conservative extensions of the discrete
Self/anti-self charge conjugate states in the helicity basis
International Nuclear Information System (INIS)
Dvoeglazov, Valeriy V.
2013-01-01
We construct self/anti-self charge conjugate (Majorana-like) states for the (1/2,0)⊕(0,1/2) representation of the Lorentz group, and their analogs for higher spins within the quantum field theory. The problem of the basis rotations and that of the selection of phases in the Dirac-like and Majorana-like field operators are considered. The discrete symmetries properties (P, C, T) are studied. Particular attention has been paid to the question of (anti)commutation of the Charge conjugation operator and the Parity in the helicity basis. Dynamical equations have also been presented. In the (1/2,0)⊕(0,1/2) representation they obey the Dirac-like equation with eight components, which has been first introduced by Markov. Thus, the Fock space for corresponding quantum fields is doubled (as shown by Ziino). The chirality and the helicity (two concepts which are frequently confused in the literature) for Dirac and Majorana states have been discussed
Self/anti-self charge conjugate states in the helicity basis
Energy Technology Data Exchange (ETDEWEB)
Dvoeglazov, Valeriy V. [UAF, Universidad de Zacatecas (Mexico)
2013-07-23
We construct self/anti-self charge conjugate (Majorana-like) states for the (1/2,0)⊕(0,1/2) representation of the Lorentz group, and their analogs for higher spins within the quantum field theory. The problem of the basis rotations and that of the selection of phases in the Dirac-like and Majorana-like field operators are considered. The discrete symmetries properties (P, C, T) are studied. Particular attention has been paid to the question of (anti)commutation of the Charge conjugation operator and the Parity in the helicity basis. Dynamical equations have also been presented. In the (1/2,0)⊕(0,1/2) representation they obey the Dirac-like equation with eight components, which has been first introduced by Markov. Thus, the Fock space for corresponding quantum fields is doubled (as shown by Ziino). The chirality and the helicity (two concepts which are frequently confused in the literature) for Dirac and Majorana states have been discussed.
The abstract GPT and GCPT groups of discrete C, P and T symmetries
Lazzeretti, Paolo
2017-07-01
Essential symmetry properties of physical quantities of classical mechanics and classical electromagnetism can be rationalized via the Abelian symmetry group GPT , with four operations (identity E, space inversion P, time reversal T, and combined PT) isomorphic to the spatial C2v point group. To account for charge conjugation C, a larger discrete group, GCPT , with eight operations (E, P, T, C , and their products, CP, CT, PT , and CPT), isomorphic to the spatial D2h point group, has been considered. Some features of these groups are discussed by a few examples, showing in particular that they provide group-theoretical implications for the existence of magnetic monopoles, magnetic scalar potential, magnetic charge density and magnetic current density, and magnetic-field induced electronic anapoles. A set of linearly independent vectors belonging to a representation space is constituted by eight fermion bilinears of quantum field theory. The GCPT group can be used to determine the discrete symmetry properties of molecular response tensors and provides interesting elucidations of established notions in a different, group-theoretical light, e.g., new understanding of duality transformations, which leave the Maxwell equations invariant, and a geometrical reinterpretation of Barron's concept of true enantiomers.
Reflection and transmission of twisted light at phase conjugating interfaces.
Thakur, Anita; Berakdar, Jamal
2012-01-16
We study the transmission and the reflection of light beams carrying orbital angular momentum through a dielectric multilayer structure containing phase-conjugating interfaces. We show analytically and demonstrate numerically that the phase conjugation at the interfaces results in a characteristic angular and radial pattern of the reflected beam, a fact that can be exploited for the detection and the characterization of phase conjugation in composite optical materials.
Evolution of conjugation and type IV secretion systems.
Guglielmini, Julien; de la Cruz, Fernando; Rocha, Eduardo P C
2013-02-01
Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and social traits among prokaryotes. Recent works unraveled the functioning of the underlying type IV secretion systems (T4SS) and its distribution and recruitment for other biological processes (exaptation), notably pathogenesis. We analyzed the phylogeny of key conjugation proteins to infer the evolutionary history of conjugation and T4SS. We show that single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) conjugation, while both based on a key AAA(+) ATPase, diverged before the last common ancestor of bacteria. The two key ATPases of ssDNA conjugation are monophyletic, having diverged at an early stage from dsDNA translocases. Our data suggest that ssDNA conjugation arose first in diderm bacteria, possibly Proteobacteria, and then spread to other bacterial phyla, including bacterial monoderms and Archaea. Identifiable T4SS fall within the eight monophyletic groups, determined by both taxonomy and structure of the cell envelope. Transfer to monoderms might have occurred only once, but followed diverse adaptive paths. Remarkably, some Firmicutes developed a new conjugation system based on an atypical relaxase and an ATPase derived from a dsDNA translocase. The observed evolutionary rates and patterns of presence/absence of specific T4SS proteins show that conjugation systems are often and independently exapted for other functions. This work brings a natural basis for the classification of all kinds of conjugative systems, thus tackling a problem that is growing as fast as genomic databases. Our analysis provides the first global picture of the evolution of conjugation and shows how a self-transferrable complex multiprotein system has adapted to different taxa and often been recruited by the host. As conjugation systems became specific to certain clades and cell envelopes, they may have biased the rate and direction of gene transfer by conjugation within prokaryotes.
Genetic drift suppresses bacterial conjugation in spatially structured populations
Freese, Peter D.; Korolev, Kirill S.; Jimenez, Jose I.; Chen, Irene A.
2014-01-01
Conjugation is the primary mechanism of horizontal gene transfer that spreads antibiotic resistance among bacteria. Although conjugation normally occurs in surface-associated growth (e.g., biofilms), it has been traditionally studied in well-mixed liquid cultures lacking spatial structure, which is known to affect many evolutionary and ecological processes. Here we visualize spatial patterns of gene transfer mediated by F plasmid conjugation in a colony of Escherichia coli growing on solid ag...
Design, synthesis, characterization and study of novel conjugated polymers
Energy Technology Data Exchange (ETDEWEB)
Chen, Wu [Iowa State Univ., Ames, IA (United States)
1997-06-24
After introducing the subject of conjugated polymers, the thesis has three sections each containing a literature survey, results and discussion, conclusions, and experimental methods on the following: synthesis, characterization of electroluminescent polymers containing conjugated aryl, olefinic, thiophene and acetylenic units and their studies for use in light-emitting diodes; synthesis, characterization and study of conjugated polymers containing silole unit in the main chain; and synthesis, characterization and study of silicon-bridged and butadiene-linked polythiophenes.
Magnetic Field Effect in Conjugated Molecules-Based Devices
2017-10-23
AFRL-AFOSR-JP-TR-2017-0073 Magnetic field effect in conjugated molecules-based devices Tzung-Fang Guo NATIONAL CHENG KUNG UNIVERSITY Final Report 10...Final 3. DATES COVERED (From - To) 22 Jul 2014 to 21 Jul 2017 4. TITLE AND SUBTITLE Magnetic field effect in conjugated molecules-based devices 5a... Magnetic field effect in conjugated molecule-based devices. The final year of the project had a collaboration with Professor Bin Hu at the University
Rational solutions of the discrete time Toda lattice and the alternate discrete Painleve II equation
International Nuclear Information System (INIS)
Common, Alan K; Hone, Andrew N W
2008-01-01
The Yablonskii-Vorob'ev polynomials y n (t), which are defined by a second-order bilinear differential-difference equation, provide rational solutions of the Toda lattice. They are also polynomial tau-functions for the rational solutions of the second Painleve equation (P II ). Here we define two-variable polynomials Y n (t, h) on a lattice with spacing h, by considering rational solutions of the discrete time Toda lattice as introduced by Suris. These polynomials are shown to have many properties that are analogous to those of the Yablonskii-Vorob'ev polynomials, to which they reduce when h = 0. They also provide rational solutions for a particular discretization of P II , namely the so-called alternate discrete P II , and this connection leads to an expression in terms of the Umemura polynomials for the third Painleve equation (P III ). It is shown that the Baecklund transformation for the alternate discrete Painleve equation is a symplectic map, and the shift in time is also symplectic. Finally we present a Lax pair for the alternate discrete P II , which recovers Jimbo and Miwa's Lax pair for P II in the continuum limit h → 0
Effect of Fatty Acid Conjugation on Antimicrobial Peptide Activity
National Research Council Canada - National Science Library
Chu-Kung, Alexander F; Bozzelli, Kristen N; Nguyen, Rose; Tirrell, Matthew V
2004-01-01
... or the conjugate of the nonamphipathic peptide, KAK. The induction of helicity corresponds to a significant improvement in antimicrobial activity as measured by a minimum bactericidal concentration test...
Sources and Bioactive Properties of Conjugated Dietary Fatty Acids.
Hennessy, Alan A; Ross, Paul R; Fitzgerald, Gerald F; Stanton, Catherine
2016-04-01
The group of conjugated fatty acids known as conjugated linoleic acid (CLA) isomers have been extensively studied with regard to their bioactive potential in treating some of the most prominent human health malignancies. However, CLA isomers are not the only group of potentially bioactive conjugated fatty acids currently undergoing study. In this regard, isomers of conjugated α-linolenic acid, conjugated nonadecadienoic acid and conjugated eicosapentaenoic acid, to name but a few, have undergone experimental assessment. These studies have indicated many of these conjugated fatty acid isomers commonly possess anti-carcinogenic, anti-adipogenic, anti-inflammatory and immune modulating properties, a number of which will be discussed in this review. The mechanisms through which these bioactivities are mediated have not yet been fully elucidated. However, existing evidence indicates that these fatty acids may play a role in modulating the expression of several oncogenes, cell cycle regulators, and genes associated with energy metabolism. Despite such bioactive potential, interest in these conjugated fatty acids has remained low relative to the CLA isomers. This may be partly attributed to the relatively recent emergence of these fatty acids as bioactives, but also due to a lack of awareness regarding sources from which they can be produced. In this review, we will also highlight the common sources of these conjugated fatty acids, including plants, algae, microbes and chemosynthesis.
Methotrexate and epirubicin conjugates as potential antitumor drugs
Directory of Open Access Journals (Sweden)
Szymon Wojciech Kmiecik
2017-07-01
Full Text Available Introduction: The use of hybrid molecules has become one of the most significant approaches in new cytotoxic drug design. This study describes synthesis and characterization of conjugates consisting of two well-known and characterized chemotherapeutic agents: methotrexate (MTX and epirubicin (EPR. The synthesized conjugates combine two significant anticancer strategies: combinatory therapy and targeted therapy. These two drugs were chosen because they have different mechanisms of action, which can increase the anticancer effect of the obtained conjugates. MTX, which is a folic acid analog, has high cytotoxic properties and can serve as a targeting moiety that can reach folate receptors (FRs overexpresing tumor cells. Combination of nonselective drugs such as EPR with MTX can increase the selectivity of the obtained conjugates, while maintaining the high cytotoxic properties.Materials and methods: Conjugates were purified by RP-HPLC and the structure was investigated by MS and MS/MS methods. The effect of the conjugates on proliferation of LoVo, LoVo/Dx, MCF-7 and MV-4-11 human cancer cell lines was determined by SRB or MTT assay.Results: The conjugation reaction results in the formation of monosubstituted (α, γ and disubstituted MTX derivatives. In vitro proliferation data demonstrate that the conjugates synthesized in our study show lower cytotoxic properties than both chemotherapeutics used alone.Discussion: Epirubicin cytotoxicity was not observed in obtained conjugates. Effective drugs release after internalization needs further investigation.
Lima, Igo T.
2014-01-01
Donor-acceptor π-conjugated copolymers are of interest for a wide range of electronic applications, including field-effect transistors and solar cells. Here, we present a density functional theory (DFT) study of the impact of varying the conjugation pathway on the geometric, electronic, and optical properties of donor-acceptor systems. We consider both linear ("in series"), traditional conjugation among the donor-acceptor moieties versus structures where the acceptor units are appended orthogonally to the linear, donor-only conjugated backbone. Long-range-corrected hybrid functionals are used in the investigation with the values of the tuned long-range separation parameters providing an estimate of the extent of conjugation as a function of the oligomer architecture. Considerable differences in the electronic and optical properties are determined as a function of the nature of the conjugation pathway, features that should be taken into account in the design of donor-acceptor copolymers.
Multicellular computing using conjugation for wiring.
Goñi-Moreno, Angel; Amos, Martyn; de la Cruz, Fernando
2013-01-01
Recent efforts in synthetic biology have focussed on the implementation of logical functions within living cells. One aim is to facilitate both internal "re-programming" and external control of cells, with potential applications in a wide range of domains. However, fundamental limitations on the degree to which single cells may be re-engineered have led to a growth of interest in multicellular systems, in which a "computation" is distributed over a number of different cell types, in a manner analogous to modern computer networks. Within this model, individual cell type perform specific sub-tasks, the results of which are then communicated to other cell types for further processing. The manner in which outputs are communicated is therefore of great significance to the overall success of such a scheme. Previous experiments in distributed cellular computation have used global communication schemes, such as quorum sensing (QS), to implement the "wiring" between cell types. While useful, this method lacks specificity, and limits the amount of information that may be transferred at any one time. We propose an alternative scheme, based on specific cell-cell conjugation. This mechanism allows for the direct transfer of genetic information between bacteria, via circular DNA strands known as plasmids. We design a multi-cellular population that is able to compute, in a distributed fashion, a Boolean XOR function. Through this, we describe a general scheme for distributed logic that works by mixing different strains in a single population; this constitutes an important advantage of our novel approach. Importantly, the amount of genetic information exchanged through conjugation is significantly higher than the amount possible through QS-based communication. We provide full computational modelling and simulation results, using deterministic, stochastic and spatially-explicit methods. These simulations explore the behaviour of one possible conjugation-wired cellular computing
Multicellular Computing Using Conjugation for Wiring
Goñi-Moreno, Angel; Amos, Martyn; de la Cruz, Fernando
2013-01-01
Recent efforts in synthetic biology have focussed on the implementation of logical functions within living cells. One aim is to facilitate both internal “re-programming” and external control of cells, with potential applications in a wide range of domains. However, fundamental limitations on the degree to which single cells may be re-engineered have led to a growth of interest in multicellular systems, in which a “computation” is distributed over a number of different cell types, in a manner analogous to modern computer networks. Within this model, individual cell type perform specific sub-tasks, the results of which are then communicated to other cell types for further processing. The manner in which outputs are communicated is therefore of great significance to the overall success of such a scheme. Previous experiments in distributed cellular computation have used global communication schemes, such as quorum sensing (QS), to implement the “wiring” between cell types. While useful, this method lacks specificity, and limits the amount of information that may be transferred at any one time. We propose an alternative scheme, based on specific cell-cell conjugation. This mechanism allows for the direct transfer of genetic information between bacteria, via circular DNA strands known as plasmids. We design a multi-cellular population that is able to compute, in a distributed fashion, a Boolean XOR function. Through this, we describe a general scheme for distributed logic that works by mixing different strains in a single population; this constitutes an important advantage of our novel approach. Importantly, the amount of genetic information exchanged through conjugation is significantly higher than the amount possible through QS-based communication. We provide full computational modelling and simulation results, using deterministic, stochastic and spatially-explicit methods. These simulations explore the behaviour of one possible conjugation-wired cellular
Projected discrete ordinates methods for numerical transport problems
Energy Technology Data Exchange (ETDEWEB)
Larsen, E.W.
1985-01-01
A class of Projected Discrete-Ordinates (PDO) methods is described for obtaining iterative solutions of discrete-ordinates problems with convergence rates comparable to those observed using Diffusion Synthetic Acceleration (DSA). The spatially discretized PDO solutions are generally not equal to the DSA solutions, but unlike DSA, which requires great care in the use of spatial discretizations to preserve stability, the PDO solutions remain stable and rapidly convergent with essentially arbitrary spatial discretizations. Numerical results are presented which illustrate the rapid convergence and the accuracy of solutions obtained using PDO methods with commonplace differencing methods.
Polar reactions of acyclic conjugated bisallenes
Directory of Open Access Journals (Sweden)
Reiner Stamm
2013-01-01
Full Text Available The chemical behaviour of various alkyl-substituted, acyclic conjugated bisallenes in reactions involving polar intermediates and/or transition states has been investigated on a broad scale for the first time. The reactions studied include lithiation, reaction of the thus formed organolithium salts with various electrophiles (among others, allyl bromide, DMF and acetone, oxidation to cyclopentenones and epoxides, hydrohalogenation (HCl, HBr addition, halogenation (Br2 and I2 addition, and [2 + 2] cycloaddition with chlorosulfonyl isocyanate. The resulting adducts were fully characterized by spectroscopic and analytical methods; they constitute interesting substrates for further organic transformations.
Modeling Transformation and Conjugation in Bacteria Populations
Russo, John; Dong, J. J.
The rise of antibiotic resistance in bacteria populations is a growing threat to medical treatment of diseases. Transformation, where a cell absorbs a plasmid from its environment, and conjugation, direct transfer of a plasmid from one cell to another, are the two main mechanisms of emergence of antibiotic resistance. We model the processes using a combined approach of Kinetic Monte Carlo simulation and differential equations to describe the plasmid-carrying and plasmid-free populations. Through analysis of our results, we characterize the conditions that lead to dominance of the antibiotic resistant population. NSF-DMR #1248387.
HPMA copolymer conjugates for dual therapy
Czech Academy of Sciences Publication Activity Database
Etrych, Tomáš; Krakovičová, Hana; Šírová, Milada; Říhová, Blanka; Ulbrich, Karel
2008-01-01
Roč. 132, č. 3 (2008), s. 63-65 ISSN 0168-3659. [European Symposium on Controlled Drug Delivery /10./. Noordwijk an Zee, 02.04.2008-04.04.2008] R&D Projects: GA MŠk 1M0505; GA AV ČR IAA400500806 Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510 Keywords : dual therapy * polymer conjugates * controlled release Subject RIV: CD - Macromolecular Chemistry Impact factor: 5.690, year: 2008
Rhenium 188 labelling of peptide conjugates
International Nuclear Information System (INIS)
Melendez-Alafort, Laura
2001-01-01
Many human tumours express high levels, of somatostatin receptors. In order to make possible a radiotherapeutic treatment of this kind for tumour a series of somatostatin analogues that can tightly chelate beta emitting isotopes have been developed in recent years. The work carried out for this thesis has been aimed towards development of a new therapeutic radiopharmaceutical for treatment of somatostatin receptor positive tumours. The first chapters describe work with technetium-99m to establish the labelling and analytical conditions for a somatostatin analogue, [Tyr 3 ]-octreotide (TOC), as a precursor to undertaking labelling studies with the beta emitter rhenium-188. 6-Hydrazinopyridine-3-carboxylic acid (HYNIC) was conjugated to TOC and labelled with 99m using different coligands. Then the stability, receptor binding and biodistribution of each complex were assessed. 99m Tc-HYNIC-TOC using EDDA as coligand showed the best characteristics, and was superior for tumour imaging in humans than the commercially available 111 In-DTPA-octreotide. The conditions for labelling the HYNIC-TOC conjugate with 188 Re were then optimised using tricine as a co-ligand. A labelling yield of ∼80% was achieved. After purification however, the stability of the complex was low. The use of other coligand systems which had proved useful for 99m Tc labelling was explored, but yields were very poor. Other chelators such as diethylenetriamine pentaacetic acid (DTPA), dimercaptosuccinic acid (DMSA) and mercaptoacetyltriglycine (MAG 3 ) were studied as potential co-ligand agents to label the HYNIC-TOC conjugate with 188 Re but, again low yields of the labelled peptide complexes were achieved. A novel 188 Re-HYNIC complex was prepared in high yields using N-N-disubstituted dithiocarbamates as coligands. However to date, the specific activities achieved with this system are relatively low. The use of the [ 99m Tc(CO) 3 (H 2 O) 3 ] complex to label the HYNIC-TOC conjugate was investigated
Directory of Open Access Journals (Sweden)
David W Scheifele
1994-01-01
Full Text Available Objective: To assess adverse effects and immune responses with a three-dose series of Haemophilus influenzae type b meningococcal protein conjugate (PedvaxHIB or Hib.OMP vaccine, including any immunological response alterations from concurrent administration with routine vaccines for infants.
Energy Technology Data Exchange (ETDEWEB)
Joshi, Deepti, E-mail: deeptimishrajoshi@gmail.com; Soni, R. K. [Indian Institute of Technology Delhi, Physics Department (India)
2015-05-15
Pure gold and silver nanoparticle (NP) generation and their conjugation with protein S-ovalbumin using in situ conjugation process have been reported. The in situ conjugation involves nanosecond pulse laser ablation of pure metal target in the protein S-ovalbumin solution. Transmission electron microscopy (TEM) and UV–Visible absorption results show decrease in mean NP size along with narrow particle size distribution on ablation in S-ovalbumin solution as compared to ablation in water for both Au and Ag NPs. Also, the NP size reduction was found to be dependent on the concentration of S-ovalbumin. For AuNPs, spherical NPs of mean size 4 nm with particle size distribution 2–6 nm were obtained at 300 nM S-ovalbumin concentration. Further, it has been observed that the resultant in situ-conjugated colloid gold and silver NP solutions were quite stable even in the presence of NaCl at physiological salt concentration (0.15 M). On post-laser irradiation (532 nm, 15 mJ) for 20 min, 9 nm red shift in surface plasmon resonance peak (SPR), along with increased broadening towards longer wavelength, was observed in the AuNPs–S-ovalbumin sample. Further increase in the time of irradiation showed shift in AuNPs–S-ovalbumin SPR towards lower wavelength. On laser irradiation (532 nm, 15 mJ) for 20 min, no significant change was observed in the line shape of the plasmon absorption band of the AgNPs–S-ovalbumin conjugate. FTIR spectra revealed that S-ovalbumin peptide backbone and secondary structure remain unchanged on laser irradiation during in situ conjugation process. Thus, integrity of S-ovalbumin does not get affected, and no degradation of S-ovalbumin takes place on laser-induced in situ conjugation. Raman results confirm that both Au and Ag NPs interact with S-ovalbumin via thiol-bearing cysteine residues of the disulfide bond.
Embedding SAS approach into conjugate gradient algorithms for asymmetric 3D elasticity problems
Energy Technology Data Exchange (ETDEWEB)
Chen, Hsin-Chu; Warsi, N.A. [Clark Atlanta Univ., GA (United States); Sameh, A. [Univ. of Minnesota, Minneapolis, MN (United States)
1996-12-31
In this paper, we present two strategies to embed the SAS (symmetric-and-antisymmetric) scheme into conjugate gradient (CG) algorithms to make solving 3D elasticity problems, with or without global reflexive symmetry, more efficient. The SAS approach is physically a domain decomposition scheme that takes advantage of reflexive symmetry of discretized physical problems, and algebraically a matrix transformation method that exploits special reflexivity properties of the matrix resulting from discretization. In addition to offering large-grain parallelism, which is valuable in a multiprocessing environment, the SAS scheme also has the potential for reducing arithmetic operations in the numerical solution of a reasonably wide class of scientific and engineering problems. This approach can be applied directly to problems that have global reflexive symmetry, yielding smaller and independent subproblems to solve, or indirectly to problems with partial symmetry, resulting in loosely coupled subproblems. The decomposition is achieved by separating the reflexive subspace from the antireflexive one, possessed by a special class of matrices A, A {element_of} C{sup n x n} that satisfy the relation A = PAP where P is a reflection matrix (symmetric signed permutation matrix).
Bahi, Jacques M; Contassot-Vivier, Sylvain
2009-08-01
This paper brings a correction to the formulation of the basins of fixed-point states of fully asynchronous discrete-time discrete-state dynamic networks presented in our paper that appeared in the IEEE Transactions on Neural Networks, vol. 17, no. 2, pp. 397-408, March 2006. In our subsequent works on totally asynchronous systems, we have discovered that the formulation given in that previous paper lacks an additional condition. We present in this paper why the previous formulation is incomplete and give the correct formulation.
Interventional tool tracking using discrete optimization.
Heibel, Hauke; Glocker, Ben; Groher, Martin; Pfister, Marcus; Navab, Nassir
2013-03-01
This work presents a novel scheme for tracking of motion and deformation of interventional tools such as guide-wires and catheters in fluoroscopic X-ray sequences. Being able to track and thus to estimate the correct positions of these tools is crucial in order to offer guidance enhancement during interventions. The task of estimating the apparent motion is particularly challenging due to the low signal-to-noise ratio (SNR) of fluoroscopic images and due to combined motion components originating from patient breathing and tool interactions performed by the physician. The presented approach is based on modeling interventional tools with B-splines whose optimal configuration of control points is determined through efficient discrete optimization. Each control point corresponds to a discrete random variable in a Markov random field (MRF) formulation where a set of labels represents the deformation space. In this context, the optimal curve corresponds to the maximum a posteriori (MAP) estimate of the MRF energy. The main motivation for employing a discrete approach is the possibility to incorporate a multi-directional search space which is robust to local minima. This is of particular interest for curve tracking under large deformation. This work analyzes feasibility of employing efficient first-order MRFs for tracking. In particular it shows how to achieve a good compromise between energy approximations and computational efficiency. Experimental results suggest to define both the external and internal energy in terms of pairwise potential functions. The method was successfully applied to the tracking of guide-wires in fluoroscopic X-ray sequences of several hundred frames which requires extremely robust techniques. Comparisons with state-of-the-art guide-wire tracking algorithms confirm the effectiveness of the proposed method.
An Einstein equation for discrete quantum gravity
Gudder, Stan
2012-01-01
The basic framework for this article is the causal set approach to discrete quantum gravity (DQG). Let $Q_n$ be the collection of causal sets with cardinality not greater than $n$ and let $K_n$ be the standard Hilbert space of complex-valued functions on $Q_n$. The formalism of DQG presents us with a decoherence matrix $D_n(x,y)$, $x,y\\in Q_n$. There is a growth order in $Q_n$ and a path in $Q_n$ is a maximal chain relative to this order. We denote the set of paths in $Q_n$ by $\\Omega_n$. For...
Newnes passive and discrete circuits pocket book
MARSTON, R M
2000-01-01
Newnes Passive and Discrete Circuits Pocket Book is aimed at all engineers, technicians, students and experimenters who can build a design directly from a circuit diagram. In a highly concise form Ray Marston presents a huge compendium of circuits that can be built as they appear, adapted or used as building blocks. The devices used have been carefully chosen for their ease of availability and reasonable price. The selection of devices has been thoroughly updated for the second edition, which has also been expanded to cover the latest ICs.The three sections of the book cover: Moder
Discrete time modelization of human pilot behavior
Cavalli, D.; Soulatges, D.
1975-01-01
This modelization starts from the following hypotheses: pilot's behavior is a time discrete process, he can perform only one task at a time and his operating mode depends on the considered flight subphase. Pilot's behavior was observed using an electro oculometer and a simulator cockpit. A FORTRAN program has been elaborated using two strategies. The first one is a Markovian process in which the successive instrument readings are governed by a matrix of conditional probabilities. In the second one, strategy is an heuristic process and the concepts of mental load and performance are described. The results of the two aspects have been compared with simulation data.
A discrete transition to advanced mathematics
Richmond, Bettina
2009-01-01
As the title indicates, this book is intended for courses aimed at bridging the gap between lower-level mathematics and advanced mathematics. The text provides a careful introduction to techniques for writing proofs and a logical development of topics based on intuitive understanding of concepts. The authors utilize a clear writing style and a wealth of examples to develop an understanding of discrete mathematics and critical thinking skills. While including many traditional topics, the text offers innovative material throughout. Surprising results are used to motivate the reader. The last thr
Generalized reciprocity principle for discrete symplectic systems
Directory of Open Access Journals (Sweden)
Julia Elyseeva
2015-12-01
Full Text Available This paper studies transformations for conjoined bases of symplectic difference systems $Y_{i+1}=\\mathcal S_{i}Y_{i}$ with the symplectic coefficient matrices $\\mathcal S_i.$ For an arbitrary symplectic transformation matrix $P_{i}$ we formulate most general sufficient conditions for $\\mathcal S_{i},\\, P_{i}$ which guarantee that $P_{i}$ preserves oscillatory properties of conjoined bases $Y_{i}.$ We present examples which show that our new results extend the applicability of the discrete transformation theory.
Time-delay analyzer with continuous discretization
International Nuclear Information System (INIS)
Bayatyan, G.L.; Darbinyan, K.T.; Mkrtchyan, K.K.; Stepanyan, S.S.
1988-01-01
A time-delay analyzer is described which when triggered by a start pulse of adjustable duration performs continuous discretization of the analyzed signal within nearly 22 ns time intervals, the recording in a memory unit with following slow read-out of the information to the computer and its processing. The time-delay analyzer consists of four CAMAC-VECTOR systems of unit width. With its help one can separate comparatively short, small-amplitude rare signals against the background of quasistationary noise processes. 4 refs.; 3 figs
Kolmogorov-Smirnov Test for Discrete Distributions
1976-03-01
34 v *v t ’c */* *v *v -v* -v* nr* "i* *t* "t* *r- *v* *v Tr T* *r» -nr "p -v- *i* *** *r *r* "V* t- FDMNS = 0.0 PDPLS = 0.0 PCP = 0.0 FDM = 0.0 CC 38...34Heuristic Approach to the Kolmogorov-Smirnov Theorems ," Annals of Mathematical Statistics , v. 20, p. 393-^03, 19^9. 7. Massey, F. J., "The Kolmogorov...Statistic in the Discrete Case," Metrika , v. 7, No. 2, p. 115-116, I963. 9. Schmid, P., "On the Kolmogorov and Smirnov Limit Theorems for
Compartmentalization analysis using discrete fracture network models
Energy Technology Data Exchange (ETDEWEB)
La Pointe, P.R.; Eiben, T.; Dershowitz, W. [Golder Associates, Redmond, VA (United States); Wadleigh, E. [Marathon Oil Co., Midland, TX (United States)
1997-08-01
This paper illustrates how Discrete Fracture Network (DFN) technology can serve as a basis for the calculation of reservoir engineering parameters for the development of fractured reservoirs. It describes the development of quantitative techniques for defining the geometry and volume of structurally controlled compartments. These techniques are based on a combination of stochastic geometry, computational geometry, and graph the theory. The parameters addressed are compartment size, matrix block size and tributary drainage volume. The concept of DFN models is explained and methodologies to compute these parameters are demonstrated.
Multi-hop conjugation based bacteria nanonetworks.
Balasubramaniam, Sasitharan; Lio', Pietro
2013-03-01
Molecular communication is a new paradigm for nanomachines to exchange information, by utilizing biological mechanism and/or components to transfer information (e.g., molecular diffusion, neuronal networks, molecular motors). One possible approach for molecular communication is through the use of bacteria, which can act as carriers for DNA-based information, i.e., plasmids. This paper analyzes multi-hop molecular nanonetworks that utilize bacteria as a carrier. The proposed approach combines different properties of bacteria to enable multi-hop transmission, such as conjugation and chemotaxis-based motility. Various analyses have been performed, including the correlation between the success rate of plasmid delivery to the destination node, and the role of conjugation in enabling this; as well as analyses on the impact of large topology shapes (e.g., Grid, Random, and Scale-free) on the success rate of plasmid delivery for multiple source-destination nanonetworks. A further solution proposed in this paper is the application of antibiotics to act as filters on illegitimate messages that could be delivered by the bacteria. Our evaluation, which has been conducted through a series of simulations, has shown that numerous bacteria properties fit to properties required for communication networking (e.g., packet filtering, routing, addressing).
Antibody-Conjugated Nanoparticles for Biomedical Applications
Directory of Open Access Journals (Sweden)
Manuel Arruebo
2009-01-01
Full Text Available Nanoscience and Nanotechnology have found their way into the fields of Biotechnology and Medicine. Nanoparticles by themselves offer specific physicochemical properties that they do not exhibit in bulk form, where materials show constant physical properties regardless of size. Antibodies are nanosize biological products that are part of the specific immune system. In addition to their own properties as pathogens or toxin neutralizers, as well as in the recruitment of immune elements (complement, improving phagocytosis, cytotoxicity antibody dependent by natural killer cells, etc., they could carry several elements (toxins, drugs, fluorochroms, or even nanoparticles, etc. and be used in several diagnostic procedures, or even in therapy to destroy a specific target. The conjugation of antibodies to nanoparticles can generate a product that combines the properties of both. For example, they can combine the small size of nanoparticles and their special thermal, imaging, drug carrier, or magnetic characteristics with the abilities of antibodies, such as specific and selective recognition. The hybrid product will show versatility and specificity. In this review, we analyse both antibodies and nanoparticles, focusing especially on the recent developments for antibody-conjugated nanoparticles, offering the researcher an overview of the different applications and possibilities of these hybrid carriers.
Discrete quantum spectrum of black holes
Energy Technology Data Exchange (ETDEWEB)
Lochan, Kinjalk, E-mail: kinjalk@iucaa.in; Chakraborty, Sumanta, E-mail: sumanta@iucaa.in
2016-04-10
The quantum genesis of Hawking radiation is a long-standing puzzle in black hole physics. Semi-classically one can argue that the spectrum of radiation emitted by a black hole look very much sparse unlike what is expected from a thermal object. It was demonstrated through a simple quantum model that a quantum black hole will retain a discrete profile, at least in the weak energy regime. However, it was suggested that this discreteness might be an artifact of the simplicity of eigen-spectrum of the model considered. Different quantum theories can, in principle, give rise to different complicated spectra and make the radiation from black hole dense enough in transition lines, to make them look continuous in profile. We show that such a hope from a geometry-quantized black hole is not realized as long as large enough black holes are dubbed with a classical mass area relation in any gravity theory ranging from GR, Lanczos–Lovelock to f(R) gravity. We show that the smallest frequency of emission from black hole in any quantum description, is bounded from below, to be of the order of its inverse mass. That leaves the emission with only two possibilities. It can either be non-thermal, or it can be thermal only with the temperature being much larger than 1/M.
Discrete quantum spectrum of black holes
International Nuclear Information System (INIS)
Lochan, Kinjalk; Chakraborty, Sumanta
2016-01-01
The quantum genesis of Hawking radiation is a long-standing puzzle in black hole physics. Semi-classically one can argue that the spectrum of radiation emitted by a black hole look very much sparse unlike what is expected from a thermal object. It was demonstrated through a simple quantum model that a quantum black hole will retain a discrete profile, at least in the weak energy regime. However, it was suggested that this discreteness might be an artifact of the simplicity of eigen-spectrum of the model considered. Different quantum theories can, in principle, give rise to different complicated spectra and make the radiation from black hole dense enough in transition lines, to make them look continuous in profile. We show that such a hope from a geometry-quantized black hole is not realized as long as large enough black holes are dubbed with a classical mass area relation in any gravity theory ranging from GR, Lanczos–Lovelock to f(R) gravity. We show that the smallest frequency of emission from black hole in any quantum description, is bounded from below, to be of the order of its inverse mass. That leaves the emission with only two possibilities. It can either be non-thermal, or it can be thermal only with the temperature being much larger than 1/M.
Focusing properties of discrete RF quadrupoles
Li, Zhi-Hui; Wang, Zhi-Jun
2017-08-01
The particle motion equation for a Radio Frequency (RF) quadrupole is derived. The motion equation shows that the general transform matrix of a RF quadrupole with length less than or equal to 0.5βλ (β is the relativistic velocity of particles and λ is wavelength of radio frequency electromagnetic field) can describe the particle motion in an arbitrarily long RF quadrupole. By iterative integration, the general transform matrix of a discrete RF quadrupole is derived from the motion equation. The transform matrix is in form of a power series of focusing parameter B. It shows that for length less than βλ, the series up to the 2nd order of B agrees well with the direct integration results for B up to 30, while for length less than 0.5βλ, the series up to 1st order is already a good approximation of the real solution for B less than 30. The formula of the transform matrix can be integrated into linac or beam line design code to deal with the focusing of discrete RF quadrupoles. Supported by National Natural Science Foundation of China (11375122, 11511140277) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDA03020705)
Dynamical Localization for Discrete Anderson Dirac Operators
Prado, Roberto A.; de Oliveira, César R.; Carvalho, Silas L.
2017-04-01
We establish dynamical localization for random Dirac operators on the d-dimensional lattice, with d\\in { 1, 2, 3} , in the three usual regimes: large disorder, band edge and 1D. These operators are discrete versions of the continuous Dirac operators and consist in the sum of a discrete free Dirac operator with a random potential. The potential is a diagonal matrix formed by different scalar potentials, which are sequences of independent and identically distributed random variables according to an absolutely continuous probability measure with bounded density and of compact support. We prove the exponential decay of fractional moments of the Green function for such models in each of the above regimes, i.e., (j) throughout the spectrum at larger disorder, (jj) for energies near the band edges at arbitrary disorder and (jjj) in dimension one, for all energies in the spectrum and arbitrary disorder. Dynamical localization in theses regimes follows from the fractional moments method. The result in the one-dimensional regime contrast with one that was previously obtained for 1D Dirac model with Bernoulli potential.
A Discrete Model for Color Naming
Menegaz, G.; Le Troter, A.; Sequeira, J.; Boi, J. M.
2006-12-01
The ability to associate labels to colors is very natural for human beings. Though, this apparently simple task hides very complex and still unsolved problems, spreading over many different disciplines ranging from neurophysiology to psychology and imaging. In this paper, we propose a discrete model for computational color categorization and naming. Starting from the 424 color specimens of the OSA-UCS set, we propose a fuzzy partitioning of the color space. Each of the 11 basic color categories identified by Berlin and Kay is modeled as a fuzzy set whose membership function is implicitly defined by fitting the model to the results of an ad hoc psychophysical experiment (Experiment 1). Each OSA-UCS sample is represented by a feature vector whose components are the memberships to the different categories. The discrete model consists of a three-dimensional Delaunay triangulation of the CIELAB color space which associates each OSA-UCS sample to a vertex of a 3D tetrahedron. Linear interpolation is used to estimate the membership values of any other point in the color space. Model validation is performed both directly, through the comparison of the predicted membership values to the subjective counterparts, as evaluated via another psychophysical test (Experiment 2), and indirectly, through the investigation of its exploitability for image segmentation. The model has proved to be successful in both cases, providing an estimation of the membership values in good agreement with the subjective measures as well as a semantically meaningful color-based segmentation map.
Correlations and discreteness in nonlinear QCD evolution
International Nuclear Information System (INIS)
Armesto, N.; Milhano, J.
2006-01-01
We consider modifications of the standard nonlinear QCD evolution in an attempt to account for some of the missing ingredients discussed recently, such as correlations, discreteness in gluon emission and Pomeron loops. The evolution is numerically performed using the Balitsky-Kovchegov equation on individual configurations defined by a given initial value of the saturation scale, for reduced rapidities y=(α s N c /π)Y<10. We consider the effects of averaging over configurations as a way to implement correlations, using three types of Gaussian averaging around a mean saturation scale. Further, we heuristically mimic discreteness in gluon emission by considering a modified evolution in which the tails of the gluon distributions are cut off. The approach to scaling and the behavior of the saturation scale with rapidity in these modified evolutions are studied and compared with the standard mean-field results. For the large but finite values of rapidity explored, no strong quantitative difference in scaling for transverse momenta around the saturation scale is observed. At larger transverse momenta, the influence of the modifications in the evolution seems most noticeable in the first steps of the evolution. No influence on the rapidity behavior of the saturation scale due to the averaging procedure is found. In the cutoff evolution the rapidity evolution of the saturation scale is slowed down and strongly depends on the value of the cutoff. Our results stress the need to go beyond simple modifications of evolution by developing proper theoretical tools that implement such recently discussed ingredients
Discrete hierarchical organization of social group sizes.
Zhou, W-X; Sornette, D; Hill, R A; Dunbar, R I M
2005-02-22
The 'social brain hypothesis' for the evolution of large brains in primates has led to evidence for the coevolution of neocortical size and social group sizes, suggesting that there is a cognitive constraint on group size that depends, in some way, on the volume of neural material available for processing and synthesizing information on social relationships. More recently, work on both human and non-human primates has suggested that social groups are often hierarchically structured. We combine data on human grouping patterns in a comprehensive and systematic study. Using fractal analysis, we identify, with high statistical confidence, a discrete hierarchy of group sizes with a preferred scaling ratio close to three: rather than a single or a continuous spectrum of group sizes, humans spontaneously form groups of preferred sizes organized in a geometrical series approximating 3-5, 9-15, 30-45, etc. Such discrete scale invariance could be related to that identified in signatures of herding behaviour in financial markets and might reflect a hierarchical processing of social nearness by human brains.
Discrete Fractional COSHAD Transform and Its Application
Directory of Open Access Journals (Sweden)
Hongqing Zhu
2014-01-01
Full Text Available In recent years, there has been a renewed interest in finding methods to construct orthogonal transforms. This interest is driven by the large number of applications of the orthogonal transforms in image analysis and compression, especially for colour images. Inspired by this motivation, this paper first introduces a new orthogonal transform known as a discrete fractional COSHAD (FrCOSHAD using the Kronecker product of eigenvectors and the eigenvalues of the COSHAD kernel functions. Next, this study discusses the properties of the FrCOSHAD kernel function, such as angle additivity. Using the algebra of quaternions, the study presents quaternion COSHAD/FrCOSHAD transforms to represent colour images in a holistic manner. This paper also develops an inverse polynomial reconstruction method (IPRM in the discrete COSHAD/FrCOSHAD domains. This method can effectively recover a piecewise smooth signal from the finite set of its COSHAD/FrCOSHAD coefficients, with high accuracy. The convergence theorem has proved that the partial sum of COSHAD provides a spectrally accurate approximation to the underlying piecewise smooth signal. The experimental results verify the numerical stability and accuracy of the proposed methods.
Discretization analysis of bifurcation based nonlinear amplifiers
Feldkord, Sven; Reit, Marco; Mathis, Wolfgang
2017-09-01
Recently, for modeling biological amplification processes, nonlinear amplifiers based on the supercritical Andronov-Hopf bifurcation have been widely analyzed analytically. For technical realizations, digital systems have become the most relevant systems in signal processing applications. The underlying continuous-time systems are transferred to the discrete-time domain using numerical integration methods. Within this contribution, effects on the qualitative behavior of the Andronov-Hopf bifurcation based systems concerning numerical integration methods are analyzed. It is shown exemplarily that explicit Runge-Kutta methods transform the truncated normalform equation of the Andronov-Hopf bifurcation into the normalform equation of the Neimark-Sacker bifurcation. Dependent on the order of the integration method, higher order terms are added during this transformation.A rescaled normalform equation of the Neimark-Sacker bifurcation is introduced that allows a parametric design of a discrete-time system which corresponds to the rescaled Andronov-Hopf system. This system approximates the characteristics of the rescaled Hopf-type amplifier for a large range of parameters. The natural frequency and the peak amplitude are preserved for every set of parameters. The Neimark-Sacker bifurcation based systems avoid large computational effort that would be caused by applying higher order integration methods to the continuous-time normalform equations.
Discretization analysis of bifurcation based nonlinear amplifiers
Directory of Open Access Journals (Sweden)
S. Feldkord
2017-09-01
Full Text Available Recently, for modeling biological amplification processes, nonlinear amplifiers based on the supercritical Andronov–Hopf bifurcation have been widely analyzed analytically. For technical realizations, digital systems have become the most relevant systems in signal processing applications. The underlying continuous-time systems are transferred to the discrete-time domain using numerical integration methods. Within this contribution, effects on the qualitative behavior of the Andronov–Hopf bifurcation based systems concerning numerical integration methods are analyzed. It is shown exemplarily that explicit Runge–Kutta methods transform the truncated normalform equation of the Andronov–Hopf bifurcation into the normalform equation of the Neimark–Sacker bifurcation. Dependent on the order of the integration method, higher order terms are added during this transformation.A rescaled normalform equation of the Neimark–Sacker bifurcation is introduced that allows a parametric design of a discrete-time system which corresponds to the rescaled Andronov–Hopf system. This system approximates the characteristics of the rescaled Hopf-type amplifier for a large range of parameters. The natural frequency and the peak amplitude are preserved for every set of parameters. The Neimark–Sacker bifurcation based systems avoid large computational effort that would be caused by applying higher order integration methods to the continuous-time normalform equations.
Discrete quantum spectrum of black holes
Directory of Open Access Journals (Sweden)
Kinjalk Lochan
2016-04-01
Full Text Available The quantum genesis of Hawking radiation is a long-standing puzzle in black hole physics. Semi-classically one can argue that the spectrum of radiation emitted by a black hole look very much sparse unlike what is expected from a thermal object. It was demonstrated through a simple quantum model that a quantum black hole will retain a discrete profile, at least in the weak energy regime. However, it was suggested that this discreteness might be an artifact of the simplicity of eigen-spectrum of the model considered. Different quantum theories can, in principle, give rise to different complicated spectra and make the radiation from black hole dense enough in transition lines, to make them look continuous in profile. We show that such a hope from a geometry-quantized black hole is not realized as long as large enough black holes are dubbed with a classical mass area relation in any gravity theory ranging from GR, Lanczos–Lovelock to f(R gravity. We show that the smallest frequency of emission from black hole in any quantum description, is bounded from below, to be of the order of its inverse mass. That leaves the emission with only two possibilities. It can either be non-thermal, or it can be thermal only with the temperature being much larger than 1/M.
Discrete Bubble Modeling for Cavitation Bubbles
Choi, Jin-Keun; Chahine, Georges; Hsiao, Chao-Tsung
2007-03-01
Dynaflow, Inc. has conducted extensive studies on non-spherical bubble dynamics and interactions with solid and free boundaries, vortical flow structures, and other bubbles. From these studies, emerged a simplified Surface Averaged Pressure (SAP) spherical bubble dynamics model and a Lagrangian bubble tracking scheme. In this SAP scheme, the pressure and velocity of the surrounding flow field are averaged on the bubble surface, and then used for the bubble motion and volume dynamics calculations. This model is implemented using the Fluent User Defined Function (UDF) as Discrete Bubble Model (DBM). The Bubble dynamics portion can be solved using an incompressible liquid modified Rayleigh-Plesset equation or a compressible liquid modified Gilmore equation. The Discrete Bubble Model is a very suitable tool for the studies on cavitation inception of foils and turbo machinery, bubble nuclei effects, noise from the bubbles, and can be used in many practical problems in industrial and naval applications associated with flows in pipes, jets, pumps, propellers, ships, and the ocean. Applications to propeller cavitation, wake signatures of waterjet propelled ships, bubble-wake interactions, modeling of cavitating jets, and bubble entrainments around a ship will be presented.
Opto-electronic properties of charged conjugated molecules
Fratiloiu, S.
2007-01-01
The aim of this thesis is to provide fundamental insight into the nature and opto-electronic properties of charge carriers on conjugated oligomers and polymers. Electronic structure, optical absorption properties and distribution of charge carriers along the chains of different conjugated materials
Computation of conjugate depths in cubic-shape open channels ...
African Journals Online (AJOL)
Determining conjugate depths for a given discharge and initial depth requires the solution of a cubic equation for the conjugate depth and there are currently two approaches to avoiding this difficulty in general. One approach is to iteratively try different depths until one is obtained which gives the same value of the ...
The Synthesis of Substituted Piperazine-cholesterol Conjugates for ...
African Journals Online (AJOL)
A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection ...
Preparation and characterization of microspheres of albumin-heparin conjugates
Kwon, Glen S.; Bae, You Han; Kim, Sung Wan; Cremers, Harry; Cremers, H.F.M.; Feijen, Jan
1991-01-01
Albumin-heparin microspheres have been prepared as a new drug carrier. A soluble albumin-heparin conjugate was synthesized by forming amide bonds between human serum albumin and heparin. After purification the albumin-heparin conjugate was crosslinked in a water-in-oil emulsion to form
Synthesis of sugars catalysed by microgel conjugated rabbit muscle ...
African Journals Online (AJOL)
Microgel has been prepared and covalently conjugated to rabbit muscle aldolase and employed to catalyse reactions between dihydroxyacetone phosphate, DHAP natural and non-natural acceptors aldehydes in aqueous, aqueous – organic solvents at ambient temperature. The microgel conjugated enzyme was found to ...
Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties
DEFF Research Database (Denmark)
Pedersen, Palle Jacob; Adolph, Sidsel K.; Andresen, Thomas Lars
2010-01-01
The synthesis of two secretory phospholipase A(2) IIA sensitive 15-deoxy-Delta(12,14)-prostaglandin J(2) phospholipid conjugates is described and their biophysical and biological properties are reported. The conjugates spontaneously form particles in the liposome size region upon dispersion in an...
Dynamics of nonlinear oscillators with time-varying conjugate coupling
Indian Academy of Sciences (India)
We explore the dynamical consequences of time-varying conjugate coupling in a system of nonlinear oscillators. We analyze the behavior of coupled ... Conjugate coupling; time varying coupling. PACS Nos 05.45.Xt. 1. Introduction ..... MDS acknowledges the financial support from DST,. New Delhi. References. [1] L Glass ...
Self-pumped phase-conjugate fiber-optic gyro.
McMichael, I; Yeh, P
1986-10-01
We describe a new type of phase-conjugate fiber-optic gyro that uses self-pumped phase conjugation. The selfpumped configuration is simpler than externally pumped configurations and permits the use of sensing fibers longer than the coherence length of the laser. A proof-of-principle demonstration of rotation sensing with the device is presented.
Cross-conjugation and quantum interference : a general correlation?
Valkenier, Hennie; Guedon, Constant M.; Markussen, Troels; Thygesen, Kristian S.; van der Molen, Sense J.; Hummelen, Jan C.
2014-01-01
We discuss the relationship between the pi-conjugation pattern, molecular length, and charge transport properties of molecular wires, both from an experimental and a theoretical viewpoint. Specifically, we focus on the role of quantum interference in the conductance properties of cross-conjugated
Mishchenko, Michael I.; Dlugach, Janna M.; Yurkin, Maxim A.; Bi, Lei; Cairns, Brian; Liu, Li; Panetta, R. Lee; Travis, Larry D.; Yang, Ping; Zakharova, Nadezhda T.
2016-01-01
A discrete random medium is an object in the form of a finite volume of a vacuum or a homogeneous material medium filled with quasi-randomly and quasi-uniformly distributed discrete macroscopic impurities called small particles. Such objects are ubiquitous in natural and artificial environments. They are often characterized by analyzing theoretically the results of laboratory, in situ, or remote-sensing measurements of the scattering of light and other electromagnetic radiation. Electromagnetic scattering and absorption by particles can also affect the energy budget of a discrete random medium and hence various ambient physical and chemical processes. In either case electromagnetic scattering must be modeled in terms of appropriate optical observables, i.e., quadratic or bilinear forms in the field that quantify the reading of a relevant optical instrument or the electromagnetic energy budget. It is generally believed that time-harmonic Maxwell's equations can accurately describe elastic electromagnetic scattering by macroscopic particulate media that change in time much more slowly than the incident electromagnetic field. However, direct solutions of these equations for discrete random media had been impracticable until quite recently. This has led to a widespread use of various phenomenological approaches in situations when their very applicability can be questioned. Recently, however, a new branch of physical optics has emerged wherein electromagnetic scattering by discrete and discretely heterogeneous random media is modeled directly by using analytical or numerically exact computer solutions of the Maxwell equations. Therefore, the main objective of this Report is to formulate the general theoretical framework of electromagnetic scattering by discrete random media rooted in the Maxwell- Lorentz electromagnetics and discuss its immediate analytical and numerical consequences. Starting from the microscopic Maxwell-Lorentz equations, we trace the development of
International Nuclear Information System (INIS)
Mishchenko, Michael I.; Dlugach, Janna M.; Yurkin, Maxim A.; Bi, Lei; Cairns, Brian; Liu, Li; Panetta, R. Lee; Travis, Larry D.; Yang, Ping; Zakharova, Nadezhda T.
2016-01-01
A discrete random medium is an object in the form of a finite volume of a vacuum or a homogeneous material medium filled with quasi-randomly and quasi-uniformly distributed discrete macroscopic impurities called small particles. Such objects are ubiquitous in natural and artificial environments. They are often characterized by analyzing theoretically the results of laboratory, in situ, or remote-sensing measurements of the scattering of light and other electromagnetic radiation. Electromagnetic scattering and absorption by particles can also affect the energy budget of a discrete random medium and hence various ambient physical and chemical processes. In either case electromagnetic scattering must be modeled in terms of appropriate optical observables, i.e., quadratic or bilinear forms in the field that quantify the reading of a relevant optical instrument or the electromagnetic energy budget. It is generally believed that time-harmonic Maxwell’s equations can accurately describe elastic electromagnetic scattering by macroscopic particulate media that change in time much more slowly than the incident electromagnetic field. However, direct solutions of these equations for discrete random media had been impracticable until quite recently. This has led to a widespread use of various phenomenological approaches in situations when their very applicability can be questioned. Recently, however, a new branch of physical optics has emerged wherein electromagnetic scattering by discrete and discretely heterogeneous random media is modeled directly by using analytical or numerically exact computer solutions of the Maxwell equations. Therefore, the main objective of this Report is to formulate the general theoretical framework of electromagnetic scattering by discrete random media rooted in the Maxwell–Lorentz electromagnetics and discuss its immediate analytical and numerical consequences. Starting from the microscopic Maxwell–Lorentz equations, we trace the development
Mishchenko, Michael I.; Dlugach, Janna M.; Yurkin, Maxim A.; Bi, Lei; Cairns, Brian; Liu, Li; Panetta, R. Lee; Travis, Larry D.; Yang, Ping; Zakharova, Nadezhda T.
2018-01-01
A discrete random medium is an object in the form of a finite volume of a vacuum or a homogeneous material medium filled with quasi-randomly and quasi-uniformly distributed discrete macroscopic impurities called small particles. Such objects are ubiquitous in natural and artificial environments. They are often characterized by analyzing theoretically the results of laboratory, in situ, or remote-sensing measurements of the scattering of light and other electromagnetic radiation. Electromagnetic scattering and absorption by particles can also affect the energy budget of a discrete random medium and hence various ambient physical and chemical processes. In either case electromagnetic scattering must be modeled in terms of appropriate optical observables, i.e., quadratic or bilinear forms in the field that quantify the reading of a relevant optical instrument or the electromagnetic energy budget. It is generally believed that time-harmonic Maxwell’s equations can accurately describe elastic electromagnetic scattering by macroscopic particulate media that change in time much more slowly than the incident electromagnetic field. However, direct solutions of these equations for discrete random media had been impracticable until quite recently. This has led to a widespread use of various phenomenological approaches in situations when their very applicability can be questioned. Recently, however, a new branch of physical optics has emerged wherein electromagnetic scattering by discrete and discretely heterogeneous random media is modeled directly by using analytical or numerically exact computer solutions of the Maxwell equations. Therefore, the main objective of this Report is to formulate the general theoretical framework of electromagnetic scattering by discrete random media rooted in the Maxwell–Lorentz electromagnetics and discuss its immediate analytical and numerical consequences. Starting from the microscopic Maxwell–Lorentz equations, we trace the development
Genetic Drift Suppresses Bacterial Conjugation in Spatially Structured Populations
Freese, Peter D.; Korolev, Kirill S.; Jiménez, José I.; Chen, Irene A.
2014-02-01
Conjugation is the primary mechanism of horizontal gene transfer that spreads antibiotic resistance among bacteria. Although conjugation normally occurs in surface-associated growth (e.g., biofilms), it has been traditionally studied in well-mixed liquid cultures lacking spatial structure, which is known to affect many evolutionary and ecological processes. Here we visualize spatial patterns of gene transfer mediated by F plasmid conjugation in a colony of Escherichia coli growing on solid agar, and we develop a quantitative understanding by spatial extension of traditional mass-action models. We found that spatial structure suppresses conjugation in surface-associated growth because strong genetic drift leads to spatial isolation of donor and recipient cells, restricting conjugation to rare boundaries between donor and recipient strains. These results suggest that ecological strategies, such as enforcement of spatial structure and enhancement of genetic drift, could complement molecular strategies in slowing the spread of antibiotic resistance genes.
Usta, M.; Wortelboer, H.M.; Vervoort, J.; Boersma, M.G.; Rietjens, I.M.C.M.; Bladeren, P.J. van; Cnubben, N.H.P.
2007-01-01
Curcumin, an α,β-unsaturated carbonyl compound, reacts with glutathione, leading to the formation of two monoglutathionyl curcumin conjugates. In the present study, the structures of both glutathione conjugates of curcumin were identified by LC-MS and one- and two-dimensional 1H NMR analysis, and
Usta, M.; Wortelboer, H.M.; Vervoort, J.J.M.; Boersma, M.G.; Rietjens, I.M.C.M.; Bladeren, van P.J.; Cnubben, N.H.P.
2007-01-01
Curcumin, an alpha,beta-unsaturated carbonyl compound, reacts with glutathione, leading to the formation of two monoglutathionyl curcumin conjugates. In the present study, the structures of both glutathione conjugates of curcumin were identified by LC-MS and one- and two-dimensional H-1 NMR
DEFF Research Database (Denmark)
Da Ros, Francesco; Lillieholm, Mads; Yankov, Metodi Plamenov
2017-01-01
The impact of signal-conjugate wavelength shift on nonlinearity compensation through optical phase conjugation is investigated for 64- and 256-QAM. Wavelength-shift independent achievable rate improvements between 0.2 and 0.3 bit/symbol are reported for shifts up to 30 nm in 500-km transmission....
Discrete-Time Nonlinear Control of VSC-HVDC System
Directory of Open Access Journals (Sweden)
TianTian Qian
2015-01-01
Full Text Available Because VSC-HVDC is a kind of strong nonlinear, coupling, and multi-input multioutput (MIMO system, its control problem is always attracting much attention from scholars. And a lot of papers have done research on its control strategy in the continuous-time domain. But the control system is implemented through the computer discrete sampling in practical engineering. It is necessary to study the mathematical model and control algorithm in the discrete-time domain. The discrete mathematical model based on output feedback linearization and discrete sliding mode control algorithm is proposed in this paper. And to ensure the effectiveness of the control system in the quasi sliding mode state, the fast output sampling method is used in the output feedback. The results from simulation experiment in MATLAB/SIMULINK prove that the proposed discrete control algorithm can make the VSC-HVDC system have good static, dynamic, and robust characteristics in discrete-time domain.
How Triage Nurses Use Discretion: a Literature Review
Directory of Open Access Journals (Sweden)
Lars Emil Fagernes Johannessen
2016-02-01
Full Text Available Discretion is quintessential for professional work. This review aims to understand how nurses use discretion when they perform urgency assessments in emergency departments with formalised triage systems—systems that are intended to reduce nurses’ use of discretion. Because little research has dealt explicitly with this topic, this review addresses the discretionary aspects of triage by reinterpreting qualitative studies of how triage nurses perform urgency assessments. The review shows (a how inexhaustive guidelines and a hectic work environment are factors that necessitate nurses’ use of discretion and (b how nurses reason within this discretionary space by relying on their experience and intuition, judging patients according to criteria such as appropriateness and believability, and creating urgency ratings together with their patients. The review also offers a synthesis of the findings’ discretionary aspects and suggests a new interactionist dimension of discretion.Keywords: Triage, discretion, emergency department, meta-ethnography, review, decision-making
Miranda, Jonatan; Arias, Noemi; Fernández-Quintela, Alfredo; del Puy Portillo, María
2014-04-01
Despite its benefits, conjugated linoleic acid (CLA) may cause side effects after long-term administration. Because of this and the controversial efficacy of CLA in humans, alternative biomolecules that may be used as functional ingredients have been studied in recent years. Thus, conjugated linolenic acid (CLNA) has been reported to be a potential anti-obesity molecule which may have additional positive effects related to obesity. According to the results reported in obesity, CLNA needs to be given at higher doses than CLA to be effective. However, because of the few studies conducted so far, it is still difficult to reach clear conclusions about the potential use of these CLNAs in obesity and its related changes (insulin resistance, dyslipidemia, or inflammation). Copyright © 2012 SEEN. Published by Elsevier Espana. All rights reserved.
Conjugate Heat Transfer Study in Hypersonic Flows
Sahoo, Niranjan; Kulkarni, Vinayak; Peetala, Ravi Kumar
2018-04-01
Coupled and decoupled conjugate heat transfer (CHT) studies are carried out to imitate experimental studies for heat transfer measurement in hypersonic flow regime. The finite volume based solvers are used for analyzing the heat interaction between fluid and solid domains. Temperature and surface heat flux signals are predicted by both coupled and decoupled CHT analysis techniques for hypersonic Mach numbers. These two methodologies are also used to study the effect of different wall materials on surface parameters. Effectiveness of these CHT solvers has been verified for the inverse problem of wall heat flux recovery using various techniques reported in the literature. Both coupled and decoupled CHT techniques are seen to be equally useful for prediction of local temperature and heat flux signals prior to the experiments in hypersonic flows.
Conjugated Linoleic Acid and Importance to Health
Directory of Open Access Journals (Sweden)
Canan Asal Ulus
2017-01-01
Full Text Available The development in science technology and the researches made in the health field showed that nutrition increases the effectiveness of medical treatment as well as maintaining the human health and singularly effective in the treatment of certain diseases. In recent years, the importance of nutritional elements called ‘Functional foods’ has increased. Functional foods provide physiological benefits and can reduce the risk of chronic diseases beyond their nutritional benefits. One of these functional compounds is conjugated linoleic acid (CLA isomers which have significant effects on human health and previously have been demonstrated in the researches carried out on people and animals. CLA’s attracted more attention after detection of its body fat accumulation reducing, antidiabetic, immune system enhancing, arteriosclerosis reducing, bone mineralization increasing effects.
Interfacial Widths of Conjugated Polymer Bilayers
Energy Technology Data Exchange (ETDEWEB)
NCSU; UC Berkeley; UCSB; Advanced Light Source; Garcia, Andres; Yan, Hongping; Sohn, Karen E.; Hexemer, Alexander; Nguyen, Thuc-Quyen; Bazan, Guillermo C.; Kramer, Edward J.; Ade, Harald
2009-08-13
The interfaces of conjugated polyelectrolyte (CPE)/poly[2-methoxy-5-(2{prime}-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) bilayers cast from differential solvents are shown by resonant soft X-ray reflectivity (RSoXR) to be very smooth and sharp. The chemical interdiffusion due to casting is limited to less than 0.6 nm, and the interface created is thus nearly 'molecularly' sharp. These results demonstrate for the first time and with high precision that the nonpolar MEH-PPV layer is not much disturbed by casting the CPE layer from a polar solvent. A baseline is established for understanding the role of interfacial structure in determining the performance of CPE-based polymer light-emitting diodes. More broadly, we anticipate further applications of RSoXR as an important tool in achieving a deeper understanding of other multilayer organic optoelectronic devices, including multilayer photovoltaic devices.
Charge Injection and Transport in Conjugated Polymers.
Malliaras, George
2007-03-01
We will overview the state-of-the-art in our understanding of charge injection and transport in conjugated polymers. We start by discussing the identifying characteristics of this class of materials, especially in relation with their structure and morphology. We follow by reviewing the advantages and limitations of experimental techniques that are used to probe charge transport. We then embark on a discussion of the fundamentals of charge transport in organics. We follow a didactic approach, where we start from transport in crystalline semiconductors and gradually introduce corrections for space charge effects, for the influence of disorder on mobility, for high charge densities, and for electric field-dependent charge densities. We compare with experimental data from polyfluorenes. We then shift our attention to charge injection. We review some of the recent theories and compared their predictions to experimental data, again from polyfluorenes. We close by proposing directions for future work.
Discrete wavelet transformations an elementary approach with applications
Van Fleet, Patrick
2008-01-01
An "applications first" approach to discrete wavelet transformations. Discrete Wavelet Transformations provides readers with a broad elementary introduction to discrete wavelet transformations and their applications. With extensive graphical displays, this self-contained book integrates concepts from calculus and linear algebra into the construction of wavelet transformations and their various applications, including data compression, edge detection in images, and signal and image denoising. The book begins with a cursory look at wavelet transformation development and illustrates its
A note on inconsistent families of discrete multivariate distributions
Ghosh, Sugata
2017-07-05
We construct a d-dimensional discrete multivariate distribution for which any proper subset of its components belongs to a specific family of distributions. However, the joint d-dimensional distribution fails to belong to that family and in other words, it is ‘inconsistent’ with the distribution of these subsets. We also address preservation of this ‘inconsistency’ property for the symmetric Binomial distribution, and some discrete distributions arising from the multivariate discrete normal distribution.
Discrete nonlinear Schrodinger equations with arbitrarily high-order nonlinearities
DEFF Research Database (Denmark)
Khare, A.; Rasmussen, Kim Ø; Salerno, M.
2006-01-01
A class of discrete nonlinear Schrodinger equations with arbitrarily high-order nonlinearities is introduced. These equations are derived from the same Hamiltonian using different Poisson brackets and include as particular cases the saturable discrete nonlinear Schrodinger equation and the Ablowitz......-Ladik equation. As a common property, these equations possess three kinds of exact analytical stationary solutions for which the Peierls-Nabarro barrier is zero. Several properties of these solutions, including stability, discrete breathers, and moving solutions, are investigated....
Chaos of discrete dynamical systems in complete metric spaces
International Nuclear Information System (INIS)
Shi Yuming; Chen Guanrong
2004-01-01
This paper is concerned with chaos of discrete dynamical systems in complete metric spaces. Discrete dynamical systems governed by continuous maps in general complete metric spaces are first discussed, and two criteria of chaos are then established. As a special case, two corresponding criteria of chaos for discrete dynamical systems in compact subsets of metric spaces are obtained. These results have extended and improved the existing relevant results of chaos in finite-dimensional Euclidean spaces
Network Science Research Laboratory (NSRL) Discrete Event Toolkit
2016-01-01
3. API Class Structure 3 3.1 Experiment_Driver 3 3.2 Discrete_Event_Base 5 3.3 Event_Logger_Base 6 4. Discrete Event Simulation Lifecycle 7 5...application programming interface ( API ) for developing real-time discrete event simulation (DES) systems, which simulate inputs, outputs, or services...the worker thread pool for execution. The number of worker threads is specified by the user application using the NDET API and is bound only by the
Discrete element modeling of subglacial sediment deformation
DEFF Research Database (Denmark)
Damsgaard, Anders; Egholm, David L.; Piotrowski, Jan A.
arithmetic potential of modern general-purpose GPUs. Using the Nvidia CUDA C toolkit, the algorithm is formulated for spherical particles in three dimensions with a linear-elastic soft-body contact model. We have coupled the DEM model to a model for porewater flow, and we present early results of particle......The Discrete Element Method (DEM) is used to explore the highly nonlinear dynamics of a granular bed when exposed to stress conditions comparable to those at the bed of warm-based glaciers. In the DEM, the material is simulated on a grain-by-grain basis, and defining the micromechanical properties...... of the inter-particle contacts parameterizes the model. For validating the numerical approach, the macromechanical behavior of the numerical material is compared to the results from successive laboratory ring-shear experiments. Overall, there is a good agreement between the geotechnical behavior of the real...
Choice certainty in Discrete Choice Experiments
DEFF Research Database (Denmark)
Uggeldahl, Kennet Christian; Jacobsen, Catrine; Lundhede, Thomas
2016-01-01
In this study, we conduct a Discrete Choice Experiment (DCE) using eye tracking technology to investigate if eye movements during the completion of choice sets reveal information about respondents’ choice certainty. We hypothesise that the number of times that respondents shift their visual...... attention between the alternatives in a choice set reflects their stated choice certainty. Based on one of the largest samples of eye tracking data in a DCE to date, we find evidence in favor of our hypothesis. We also link eye tracking observations to model-based choice certainty through parameterization...... of the scale function in a random parameters logit model. We find that choices characterized by more frequent gaze shifting do indeed exhibit a higher degree of error variance, however, this effects is insignificant once response time is controlled for. Overall, findings suggest that eye tracking can provide...
Discrete cosine transform using modified DPCM
Pogribny, Wlodzimierz; Drechny, Marcin
2004-07-01
Differential modulations such as Delta Modulation (DM) are used for representing digital signals in small word length codes. They allow high fast acting and simplicity of specialized processors. The use of DM for the economical representation and efficient processing of the signals needs the development of the existing methods and the working out of simple and fast processing methods in real time. Therefore Discrete Cosine Transform (DCT) methods were proposed in mixed formats which have the advantages both DCT with PCM and DCT with DM. In this work there have been studied the ways of choosing DM parameters in order to use them in these methods. On the basis of the worked out computer simulation program, the accuracy of DCT with DM algorithms has been examined by means of processing signals like noise and voice. The use of DCT algorithms in DM formats is expedient to realization of neural systems.
Discrete and Continuous Models for Partitioning Problems
Lellmann, Jan
2013-04-11
Recently, variational relaxation techniques for approximating solutions of partitioning problems on continuous image domains have received considerable attention, since they introduce significantly less artifacts than established graph cut-based techniques. This work is concerned with the sources of such artifacts. We discuss the importance of differentiating between artifacts caused by discretization and those caused by relaxation and provide supporting numerical examples. Moreover, we consider in depth the consequences of a recent theoretical result concerning the optimality of solutions obtained using a particular relaxation method. Since the employed regularizer is quite tight, the considered relaxation generally involves a large computational cost. We propose a method to significantly reduce these costs in a fully automatic way for a large class of metrics including tree metrics, thus generalizing a method recently proposed by Strekalovskiy and Cremers (IEEE conference on computer vision and pattern recognition, pp. 1905-1911, 2011). © 2013 Springer Science+Business Media New York.
Discrete computational mechanics for stiff phenomena
Michels, Dominik L.
2016-11-28
Many natural phenomena which occur in the realm of visual computing and computational physics, like the dynamics of cloth, fibers, fluids, and solids as well as collision scenarios are described by stiff Hamiltonian equations of motion, i.e. differential equations whose solution spectra simultaneously contain extremely high and low frequencies. This usually impedes the development of physically accurate and at the same time efficient integration algorithms. We present a straightforward computationally oriented introduction to advanced concepts from classical mechanics. We provide an easy to understand step-by-step introduction from variational principles over the Euler-Lagrange formalism and the Legendre transformation to Hamiltonian mechanics. Based on such solid theoretical foundations, we study the underlying geometric structure of Hamiltonian systems as well as their discrete counterparts in order to develop sophisticated structure preserving integration algorithms to efficiently perform high fidelity simulations.
Discrete motor coordinates for vowel production.
Directory of Open Access Journals (Sweden)
María Florencia Assaneo
Full Text Available Current models of human vocal production that capture peripheral dynamics in speech require large dimensional measurements of the neural activity, which are mapped into equally complex motor gestures. In this work we present a motor description for vowels as points in a discrete low-dimensional space. We monitor the dynamics of 3 points at the oral cavity using Hall-effect transducers and magnets, describing the resulting signals during normal utterances in terms of active/inactive patterns that allow a robust vowel classification in an abstract binary space. We use simple matrix algebra to link this representation to the anatomy of the vocal tract and to recent reports of highly tuned neuronal activations for vowel production, suggesting a plausible global strategy for vowel codification and motor production.
Ordinal Welfare Comparisons with Multiple Discrete Indicators
DEFF Research Database (Denmark)
Arndt, Channing; Distante, Roberta; Hussain, M. Azhar
We develop an ordinal method for making welfare comparisons between populations with multidimensional discrete well-being indicators observed at the micro level. The approach assumes that, for each well-being indicator, the levels can be ranked from worse to better; however, no assumptions are made...... about relative importance of any dimension nor about complementarity/substitutability relationships between dimensions. The method is based on the concept of multidimensional first order dominance. We introduce a rapid and reliable algorithm for empirically determining whether one population dominates...... another on the basis of available binary indicators by drawing upon linear programming theory. These approaches are applied to household survey data from Vietnam and Mozambique with a focus on child poverty comparisons over time and between regions....
Discrete canonical transforms that are Hadamard matrices
International Nuclear Information System (INIS)
Healy, John J; Wolf, Kurt Bernardo
2011-01-01
The group Sp(2,R) of symplectic linear canonical transformations has an integral kernel which has quadratic and linear phases, and which is realized by the geometric paraxial optical model. The discrete counterpart of this model is a finite Hamiltonian system that acts on N-point signals through N x N matrices whose elements also have a constant absolute value, although they do not form a representation of that group. Those matrices that are also unitary are Hadamard matrices. We investigate the manifolds of these N x N matrices under the Sp(2,R) equivalence imposed by the model, and find them to be on two-sided cosets. By means of an algorithm we determine representatives that lead to collections of mutually unbiased bases.
Discrete Line Congruences for Shading and Lighting
Wang, Jun
2013-07-01
Two-parameter families of straight lines (line congruences) are implicitly present in graphics and geometry processing in several important ways including lighting and shape analysis. In this paper we make them accessible to optimization and geometric computing, by introducing a general discrete version of congruences based on piecewise-linear correspondences between triangle meshes. Our applications of congruences are based on the extraction of a so-called torsion-free support structure, which is a procedure analogous to remeshing a surface along its principal curvature lines. A particular application of such structures are freeform shading and lighting systems for architecture. We combine interactive design of such systems with global optimization in order to satisfy geometric constraints. In this way we explore a new area where architecture can greatly benefit from graphics.
Rumor Processes on and Discrete Renewal Processes
Gallo, Sandro; Garcia, Nancy L.; Junior, Valdivino Vargas; Rodríguez, Pablo M.
2014-05-01
We study two rumor processes on , the dynamics of which are related to an SI epidemic model with long range transmission. Both models start with one spreader at site and ignorants at all the other sites of , but differ by the transmission mechanism. In one model, the spreaders transmit the information within a random distance on their right, and in the other the ignorants take the information from a spreader within a random distance on their left. We obtain the probability of survival, information on the distribution of the range of the rumor and limit theorems for the proportion of spreaders. The key step of our proofs is to show that, in each model, the position of the spreaders on can be related to a suitably chosen discrete renewal process.
Discrete optimization in architecture extremely modular systems
Zawidzki, Machi
2017-01-01
This book is comprised of two parts, both of which explore modular systems: Pipe-Z (PZ) and Truss-Z (TZ), respectively. It presents several methods of creating PZ and TZ structures subjected to discrete optimization. The algorithms presented employ graph-theoretic and heuristic methods. The underlying idea of both systems is to create free-form structures using the minimal number of types of modular elements. PZ is more conceptual, as it forms single-branch mathematical knots with a single type of module. Conversely, TZ is a skeletal system for creating free-form pedestrian ramps and ramp networks among any number of terminals in space. In physical space, TZ uses two types of modules that are mirror reflections of each other. The optimization criteria discussed include: the minimal number of units, maximal adherence to the given guide paths, etc.
Discrete Dynamical Models of Walking Droplets
Rahman, Aminur
2017-11-01
In recent years discrete planar dynamical models of walking droplets (walkers) on a billiards table (Shirokoff, Chaos 2013) and walking in a straight-line confined geometry (Gilet, PRE 2014) have been developed. Gilet's model was then analyzed via dynamical systems theory (Rahman-Blackmore, C,S& F 2016). From the analysis it was shown that while Gilet's walker is confined under the threshold for chaos, it does escape the boundary once the system becomes chaotic. We modify the model to trap the walker in an annulur domain. This allows for connections between the dynamics, statistics, and experimental works (Filoux et al., PRE 2015). From this connection we derive a kicked rotator-like model for a walker in an annulus. We endeavor to manipulate the dynamics of the model to produce statistics similar to that of experiments.
Perceptual image coding with discrete cosine transform
Tan, Ee-Leng
2015-01-01
This book first introduces classic as well as recent computational models for just-noticeable-difference (JND) applications. Since the discrete cosine transform (DCT) is applied in many image and video standards (JPEG, MPEG-1/2/4, H.261/3), the book also includes a comprehensive survey of computational models for JND that are based on DCT. The visual factors used in these computational models are reviewed in detail. Further, an extensive comparative analysis of these models using quantitative and qualitative performance criteria is presented, which compares the noise shaping performance of these models with subjective evaluation and the accuracy between the estimated JND thresholds and subjective evaluation. There are many surveys available on computational models for JND; however, these surveys seldom compare the performance of computational models that are based on DCT. The authors’ survey of the computational models and their in-depth review of the visual factors used in them will help readers understand...
Discrete symmetries: A broken look at QCD
International Nuclear Information System (INIS)
Goldman, T.
1996-01-01
The alphabet soup of discrete symmetries is briefly surveyed with a view towards those which can be tested at LISS and two particularly interesting cases are called out. A LISS experiment may be able to distinguish CP violation that is not due to the QCD θ term. The elements of a model of parity violation in proton-nucleon scattering, which is consistent with lower energy LAMPF and ANL results, are reviewed in the light of new information on diquarks and the proton spin fraction carried by quarks. The prediction that the parity violating total cross section asymmetry should be large at LISS energies is confirmed. The results of such an experiment can be used both to obtain new information about the diquark substructure of the nucleon and to provide bounds on new right-chiral weak interactions
Discrete optimization in architecture architectural & urban layout
Zawidzki, Machi
2016-01-01
This book presents three projects that demonstrate the fundamental problems of architectural design and urban composition – the layout design, evaluation and optimization. Part I describes the functional layout design of a residential building, and an evaluation of the quality of a town square (plaza). The algorithm for the functional layout design is based on backtracking using a constraint satisfaction approach combined with coarse grid discretization. The algorithm for the town square evaluation is based on geometrical properties derived directly from its plan. Part II introduces a crowd-simulation application for the analysis of escape routes on floor plans, and optimization of a floor plan for smooth crowd flow. The algorithms presented employ agent-based modeling and cellular automata.
Discrete-event control of stochastic networks multimodularity and regularity
Altman, Eitan; Hordijk, Arie
2003-01-01
Opening new directions in research in both discrete event dynamic systems as well as in stochastic control, this volume focuses on a wide class of control and of optimization problems over sequences of integer numbers. This is a counterpart of convex optimization in the setting of discrete optimization. The theory developed is applied to the control of stochastic discrete-event dynamic systems. Some applications are admission, routing, service allocation and vacation control in queueing networks. Pure and applied mathematicians will enjoy reading the book since it brings together many disciplines in mathematics: combinatorics, stochastic processes, stochastic control and optimization, discrete event dynamic systems, algebra.
Discrete Wavelet Transform-Partial Least Squares Versus Derivative ...
African Journals Online (AJOL)
Discrete Wavelet Transform-Partial Least Squares Versus Derivative Ratio Spectrophotometry for Simultaneous Determination of Chlorpheniramine Maleate and Dexamethasone in the Presence of Parabens in Pharmaceutical Dosage Form.
Distributed discrete event simulation. Final report
Energy Technology Data Exchange (ETDEWEB)
De Vries, R.C. [Univ. of New Mexico, Albuquerque, NM (United States). EECE Dept.
1988-02-01
The presentation given here is restricted to discrete event simulation. The complexity of and time required for many present and potential discrete simulations exceeds the reasonable capacity of most present serial computers. The desire, then, is to implement the simulations on a parallel machine. However, certain problems arise in an effort to program the simulation on a parallel machine. In one category of methods deadlock care arise and some method is required to either detect deadlock and recover from it or to avoid deadlock through information passing. In the second category of methods, potentially incorrect simulations are allowed to proceed. If the situation is later determined to be incorrect, recovery from the error must be initiated. In either case, computation and information passing are required which would not be required in a serial implementation. The net effect is that the parallel simulation may not be much better than a serial simulation. In an effort to determine alternate approaches, important papers in the area were reviewed. As a part of that review process, each of the papers was summarized. The summary of each paper is presented in this report in the hopes that those doing future work in the area will be able to gain insight that might not otherwise be available, and to aid in deciding which papers would be most beneficial to pursue in more detail. The papers are broken down into categories and then by author. Conclusions reached after examining the papers and other material, such as direct talks with an author, are presented in the last section. Also presented there are some ideas that surfaced late in the research effort. These promise to be of some benefit in limiting information which must be passed between processes and in better understanding the structure of a distributed simulation. Pursuit of these ideas seems appropriate.
Aptamer-conjugated nanobubbles for targeted ultrasound molecular imaging.
Wang, Chung-Hsin; Huang, Yu-Fen; Yeh, Chih-Kuang
2011-06-07
Targeted ultrasound contrast agents can be prepared by some specific bioconjugation techniques. The biotin-avidin complex is an extremely useful noncovalent binding system, but the system might induce immunogenic side effects in human bodies. Previous proposed covalently conjugated systems suffered from low conjugation efficiency and complex procedures. In this study, we propose a covalently conjugated nanobubble coupling with nucleic acid ligands, aptamers, for providing a higher specific affinity for ultrasound targeting studies. The sgc8c aptamer was linked with nanobubbles through thiol-maleimide coupling chemistry for specific targeting to CCRF-CEM cells. Further improvements to reduce the required time and avoid the degradation of nanobubbles during conjugation procedures were also made. Several investigations were used to discuss the performance and consistency of the prepared nanobubbles, such as size distribution, conjugation efficiency analysis, and flow cytometry assay. Further, we applied our conjugated nanobubbles to ex vivo ultrasound targeted imaging and compared the resulting images with optical images. The results indicated the availability of aptamer-conjugated nanobubbles in targeted ultrasound imaging and the practicability of using a highly sensitive ultrasound system in noninvasive biological research.
Vitamin Bc -Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics.
Kim, Jiyoung; Kim, Kyoung Sub; Park, Sin-jung; Na, Kun
2015-08-01
The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis and photodynamic therapy of a tumor. The synthesized vitamin Bc -bearing hydrophilic photosensitizer conjugate has been characterized for the folic acid receptor expressing the ability to target tumor cells, which is facilitated by the chemical conjugation with folic acid. The vitamin Bc -bearing hydrophilic photosensitizer conjugate internalization mechanism was identified through a competitive inhibition test with free folic acid. We optimized the laser-sensitive, cytotoxicity changeable, vitamin Bc -bearing hydrophilic photosensitizer conjugate concentration, which is non-cytotoxic under normal conditions and specifically cytotoxic toward cancer cells (maximum 69.15%) under laser irradiation conditions used for theranostic agents. The cancer therapeutic and diagnosis effects of synthesized conjugate were confirmed in MDA-MB-231 cells and MDA-MB-231-bearing mice. As a result, the vitamin Bc -bearing hydrophilic photosensitizer conjugate exhibited a highly photodynamic therapeutic effect, which enabled the selective detection of a folic acid receptor expressing cancer using optical imaging. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Studies of phase-conjugate optical device concepts
McMichael, I. C.; Yeh, P. A.
1989-03-01
Phase-conjugate gyroscopy is a new area promising significant advances in state-of-the-art inertial navigation. This contract demonstrated the first phase-conjugate fiber-optic gyros (PCFOG's) and their ability to use low cost multimode fiber components. The development of the PCFOG is now at the stage where its sources of noise and drift can be isolated, and its competitiveness with conventional fiber optic gyros can be tested. To come to this stage in development, several scientific and technical issues had to be resolved. For example, to correct for the modal scrambling of multimode fibers, the theory and practice of polarization preserving conjugators that worked at milliwatt power levels had to be developed and tested. Another issue was the mutual coherence requirement for two beams interacting with a self-pumped conjugator that at first restricted the PCFOG from using the most desireable form of biasing (fast phase modulation). This issue was resolved only recently when a new class of phase conjugators (mutually pumped conjugators) was developed that have the ability to operate with mutually incoherent beams. Almost as quickly as the first mutually pumped conjugators were discovered, this contract demonstrated the first PCFOG to use one. In addition to, and in the process of developing the PCFOG, this contract investigated several new photorefractive phenomena.
Synthesis and antimicrobial activity of gold nanoparticle conjugates with cefotaxime
Titanova, Elena O.; Burygin, Gennady L.
2016-04-01
Gold nanoparticles (GNPs) have attracted significant interest as a novel platform for various applications to nanobiotechnology and biomedicine. The conjugates of GNPs with antibiotics and antibodies were also used for selective photothermal killing of protozoa and bacteria. Also the conjugates of some antibiotics with GNPs decreased the number of bacterial growing cells. In this work was made the procedure optimization for conjugation of cefotaxime (a third-generation cephalosporin antibiotic) with GNPs (15 nm) and we examined the antimicrobial properties of this conjugate to bacteria culture of E. coli K-12. Addition of cefotaxime solution to colloidal gold does not change their color and extinction spectrum. For physiologically active concentration of cefotaxime (3 μg/mL), it was shown that the optimum pH for the conjugation was more than 9.5. A partial aggregation of the GNPs in saline medium was observed at pH 6.5-7.5. The optimum concentration of K2CO3 for conjugation cefotaxime with GNPs-15 was 5 mM. The optimum concentration of cefotaxime was at 0.36 μg/mL. We found the inhibition of the growth of E. coli K12 upon application cefotaxime-GNP conjugates.
Potent peptide-conjugated silicon phthalocyanines for tumor photodynamic therapy.
Liu, Qian; Pang, Mingpei; Tan, Sihai; Wang, Jin; Chen, Qingle; Wang, Kai; Wu, Wenjie; Hong, Zhangyong
2018-01-01
Phthalocyanines (Pcs) are a group of promising photosensitizers for use in photodynamic therapy (PDT). However, their extremely low solubility and their strong tendency to aggregate in aqueous solution greatly restrict their application. Conjugation of Pc macrocycles with peptide ligands could be a very useful strategy to optimize the physical properties of Pcs not only by increasing their water solubility and reducing their aggregation but also by endowing the conjugates with a tumor-targeting capability. To develop highly potent photosensitizers for tumor PDT, we prepared new peptide-conjugated photosensitizers using silicon Pc (SiPc), which has much higher photodynamic activity than zinc Pcs, as the light activation moiety and the cRGDfK peptide (or simply cRGD) as the peptide moiety. A polyethylene glycol linker and an extra carboxylic acid group were also tested for introduction into the conjugates to optimize the conjugate structure. The conjugates' photophysical and photodynamic behaviors were then carefully evaluated and compared using in vitro and in vivo experiments. One of the prepared conjugates, RGD-(Linker) 2 -Glu-SiPc, showed excellent physical properties and photodynamic activity, with an EC 50 (half maximal effective concentration) of 10-20 nM toward various cancer cells. This conjugate eradicated human glioblastoma U87-MG tumors in a xenograft murine tumor model after only one dose of photodynamic treatment, with no tumor regrowth during observation for up to 35 days. The conjugate RGD-(Linker) 2 -Glu-SiPc thus showed highly promising potential for use in tumor treatment.
Directory of Open Access Journals (Sweden)
AMBIKA DORAISAMY
2017-06-01
Full Text Available A digital watermark is defined as inaudible data, permanently embedded in a speech file for authenticating the secret data. The main goal of this paper is to embed a watermark in the speech signal without any degradation. Here the hybrid watermarking is performed based on the three techniques such as Discrete Cosine Transform (DCT with Singular Value Decomposition (SVD and Discrete Wavelet Transform (DWT and it is optimized by performing the separation of speech and silent regions using a voice activity detection algorithm. The performances were evaluated based on Peak Signal to Noise Ratio (PSNR and Normalized Cross Correlation (NCC. The result shows that the optimization method performs better than the existing algorithm and it is robust against different kinds of attacks. It also shows that the algorithm is efficient in terms of robustness, security, and imperceptibility and also the watermarked signal is perceptually similar to the original audio signal.
Directory of Open Access Journals (Sweden)
SERGIY KOZERENKO
2016-04-01
Full Text Available One feature of the famous Sharkovsky’s theorem is that it can be proved using digraphs of a special type (the so–called Markov graphs. The most general definition assigns a Markov graph to every continuous map from the topological graph to itself. We show that this definition is too broad, i.e. every finite digraph can be viewed as a Markov graph of some one–dimensional dynamical system on a tree. We therefore consider discrete analogues of Markov graphs for vertex maps on combinatorial trees and characterize all maps on trees whose discrete Markov graphs are of the following types: complete, complete bipartite, the disjoint union of cycles, with every arc being a loop.
International Nuclear Information System (INIS)
Aruchunan, E.
2015-01-01
In this paper, we have examined the effectiveness of the quarter-sweep iteration concept on conjugate gradient normal residual (CGNR) iterative method by using composite Simpson's (CS) and finite difference (FD) discretization schemes in solving Fredholm integro-differential equations. For comparison purposes, Gauss- Seidel (GS) and the standard or full- and half-sweep CGNR methods namely FSCGNR and HSCGNR are also presented. To validate the efficacy of the proposed method, several analyses were carried out such as computational complexity and percentage reduction on the proposed and existing methods. (author)
Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs
Directory of Open Access Journals (Sweden)
Houzong Yao
2016-02-01
Full Text Available Antibody-drug conjugates (ADCs have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.
CONJUGATED POLYMERS AND POLYELECTROLYTES IN SOLAR PHOTOCONVERSION, Final Technical Report
Energy Technology Data Exchange (ETDEWEB)
Schanze, Kirk S [University of Florida
2014-08-05
This DOE-supported program investigated the fundamental properties of conjugated polyelectrolytes, with emphasis placed on studies of excited state energy transport, self-assembly into conjugated polyelectroyte (CPE) based films and colloids, and exciton transport and charge injection in CPE films constructed atop wide bandgap semiconductors. In the most recent grant period we have also extended efforts to examine the properties of low-bandgap donor-acceptor conjugated polyelectrolytes that feature strong visible light absorption and the ability to adsorb to metal-oxide interfaces.
Site-Selective Conjugation of Native Proteins with DNA
DEFF Research Database (Denmark)
Trads, Julie Brender; Tørring, Thomas; Gothelf, Kurt Vesterager
2017-01-01
-protein conjugates. In DNA nanotechnology, the DNA handle is exploited to precisely position proteins by self-assembly. For these applications, site-selective conjugation is almost always desired because fully functional proteins are required to maintain the specificity of antibodies and the activity of enzymes...... because approximately one-third of all wild-type proteins contain metal-binding sites, including many IgG antibodies, and it is also applicable to His-tagged proteins. This emerging field provides direct access to site-selective conjugates of DNA to commercially available proteins. In this Account, we...
A qualidade conjugal e os estilos educativos parentais
Mosmann, Clarisse Pereira
2007-01-01
Esta Tese de Doutorado investiga a relação entre a qualidade do relacionamento conjugal e os estilos educativos parentais. O trabalho é apresentado na forma de artigos, sendo um artigo de revisão crítica da literatura e dois artigos empíricos, preparados para serem encaminhados para periódico científico. O primeiro artigo apresenta uma revisão teórica da literatura na área da qualidade conjugal. Este artigo buscou definir o conceito de qualidade conjugal e para tanto analisou-se sete teorias ...
Conjugation vs hyperconjugation in molecular structure of acrolein
Shishkina, Svitlana V.; Slabko, Anzhelika I.; Shishkin, Oleg V.
2013-01-01
Analysis of geometric parameters of butadiene and acrolein reveals the contradiction between the Csp2-Csp2 bond length in acrolein and classical concept of conjugation degree in the polarized molecules. In this Letter the reasons of this contradiction have been investigated. It is concluded that the Csp2-Csp2 bond length in acrolein is determined by influence of the bonding for it π-π conjugation and antibonding n → σ∗ hyperconjugation between the oxygen lone pair and the antibonding orbital of the single bond. It was shown also this bond length depends on the difference in energy of conjugative and hyperconjugative interactions.
Effective Local-Global Upscaling of Fractured Reservoirs under Discrete Fractured Discretization
Directory of Open Access Journals (Sweden)
Junchao Li
2015-09-01
Full Text Available The subsurface flow in fractured reservoirs is strongly affected by the distribution of fracture networks. Discrete fracture models, which represent all fractures individually by unstructured grid systems, are thus developed and act as a more accurate way for fractured reservoir simulation. However, it is usually not realistic to directly apply discrete fracture models to simulate field scale models for efficiency reasons. There is a need for upscaling techniques to coarsen the high resolution fracture descriptions to sizes that can be accommodated by reservoir simulators. In this paper, we extended the adaptive local-global upscaling technique to construct a transmissibility-based dual-porosity dual-permeability model from discrete fracture characterizations. An underlying unstructured fine-scale grid is firstly generated as a base grid. A global coarse-scale simulation is performed to provide boundary conditions for local regions and local upscaling procedures are carried out in every local region for transmissibility calculations. Iterations are performed until the consistency between the global and local properties is achieved. The procedure is applied to provide dual-porosity dual-permeability (DPDK parameters including coarse-scale matrix-matrix, fracture-fracture and matrix-fracture flux transmissibilities. The methodology is applied to several cases. The simulation results demonstrate the accuracy, efficiency and robustness of the proposed method.
Rui, Liyun; Xie, Minhao; Hu, Bing; Zhou, Li; Saeeduddin, Muhammad; Zeng, Xiaoxiong
2017-08-15
Chlorogenic acid-chitosan conjugate was synthesized by introducing of chlorogenic acid onto chitosan with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and hydroxybenzotriazole. The data of UV-vis, FT-IR and NMR for chlorogenic acid-chitosan conjugates demonstrated the successful conjugation of chlorogenic acid with chitosan. Compared to chitosan, chlorogenic acid-chitosan conjugates exhibited increased solubility in distilled water, 1% acetic acid solution (v/v) or 50% ethanol solution (v/v) containing 0.5% acetic acid. Moreover, chlorogenic acid-chitosan conjugates showed dramatic enhancements in metal ion chelating activity, total antioxidant capacity, scavenging activities on 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) and superoxide radicals, inhibitory effects on lipid peroxidation and β-carotene-linoleic acid bleaching, and protective effect on H 2 O 2 -induced oxidative injury of PC12 cells. Particularly, chlorogenic acid-chitosan conjugate exhibited higher inhibitory effects on lipid peroxidation and β-carotene-linoleic acid bleaching than chlorogenic acid. The results suggested that chlorogenic acid-chitosan conjugates could serve as food supplements to enhance the function of foods in future. Copyright © 2017 Elsevier Ltd. All rights reserved.
Pollution free discretization of Maxwell's equations in terms of potentials
International Nuclear Information System (INIS)
Jaun, A.; Appert, K.; Vaclavik, J.
1994-03-01
A 2D discretization of Maxwell's equations is studied in terms of the electromagnetic potentials using linear and cubic finite elements. The formulation is first analyzed with respect to the discrete dispersion properties to show that it is pollution free. It is then further applied to a simple cylindrical waveguide problem, showing good convergence to the analytical eigenfrequencies. (author) 6 figs., 13 refs
Discrete inverse scattering theory and the continuum limit
International Nuclear Information System (INIS)
Berryman, J.G.; Greene, R.R.
1978-01-01
The class of satisfactory difference approximations for the Schroedinger equation in discrete inverse scattering theory is shown smaller than previously supposed. A fast algorithm (analogous to the Levinson algorithm for Toeplitz matrices) is found for solving the discrete inverse problem. (Auth.)
ON DISTRIBUTIONS OF ORDER STATISTICS FROM NONIDENTICAL DISCRETE VARIABLES
Directory of Open Access Journals (Sweden)
Mehmet GÜNGÖR
2011-04-01
Full Text Available In this study, the distributions of X_r:n order statistic of innid discrete random variables are obtained.In addition, the distributions are also expressed in the form of an integral. Then, the results related to pf and dfof minimum and maximum order statistics of innid discrete random variables are given.
Characterization of Stochastic Dominance for Discrete Random Variable
Courtault, Jean-Michel; Crettez, Bertrand; Hayek, Naïla
2006-01-01
Working paper; Available characterizations of the various notions of stochastic dominance concern continuous random variables. Yet, discrete random variables are often used either in pedagogical presentations of stochastic dominance or in experimental tests of this notion. This note provides complete characterizations of the various notions of stochastic dominance for discrete random variables.
On order statistics from nonidentical discrete random variables
Directory of Open Access Journals (Sweden)
Yüzbaşı Bahadır
2016-01-01
Full Text Available In this study, pf and df of single order statistic of nonidentical discrete random variables are obtained. These functions are also expressed in integral form. Finally, pf and df of extreme of order statistics of random variables for the nonidentical discrete case are given.
Discreteness criteria in PU(1,n;C)
Indian Academy of Sciences (India)
Introduction. The discreteness of Möbius groups is a fundamental problem, which have been discussed by many authors. In 1976, Jørgensen [10] proved a necessary condition for a non-elementary two generator subgroup of SL(2,C) to be discrete, which is called Jørgensen's inequality. By using this inequality, Jørgensen ...
On approximation of Lie groups by discrete subgroups
Indian Academy of Sciences (India)
voila.fr; salah.suissi@yahoo.fr. MS received 11 August 2012; revised 27 January 2013. Abstract. A locally compact group G is said to be approximated by discrete sub- groups (in the sense of Tôyama) if there is a sequence of discrete subgroups ...
GENERATION ALGORITHM OF DISCRETE LINE IN MULTI-DIMENSIONAL GRIDS
Directory of Open Access Journals (Sweden)
L. Du
2017-09-01
Full Text Available Discrete Global Grids System (DGGS is a kind of digital multi-resolution earth reference model, in terms of structure, it is conducive to the geographical spatial big data integration and mining. Vector is one of the important types of spatial data, only by discretization, can it be applied in grids system to make process and analysis. Based on the some constraint conditions, this paper put forward a strict definition of discrete lines, building a mathematic model of the discrete lines by base vectors combination method. Transforming mesh discrete lines issue in n-dimensional grids into the issue of optimal deviated path in n-minus-one dimension using hyperplane, which, therefore realizing dimension reduction process in the expression of mesh discrete lines. On this basis, we designed a simple and efficient algorithm for dimension reduction and generation of the discrete lines. The experimental results show that our algorithm not only can be applied in the two-dimensional rectangular grid, also can be applied in the two-dimensional hexagonal grid and the three-dimensional cubic grid. Meanwhile, when our algorithm is applied in two-dimensional rectangular grid, it can get a discrete line which is more similar to the line in the Euclidean space.
Generation Algorithm of Discrete Line in Multi-Dimensional Grids
Du, L.; Ben, J.; Li, Y.; Wang, R.
2017-09-01
Discrete Global Grids System (DGGS) is a kind of digital multi-resolution earth reference model, in terms of structure, it is conducive to the geographical spatial big data integration and mining. Vector is one of the important types of spatial data, only by discretization, can it be applied in grids system to make process and analysis. Based on the some constraint conditions, this paper put forward a strict definition of discrete lines, building a mathematic model of the discrete lines by base vectors combination method. Transforming mesh discrete lines issue in n-dimensional grids into the issue of optimal deviated path in n-minus-one dimension using hyperplane, which, therefore realizing dimension reduction process in the expression of mesh discrete lines. On this basis, we designed a simple and efficient algorithm for dimension reduction and generation of the discrete lines. The experimental results show that our algorithm not only can be applied in the two-dimensional rectangular grid, also can be applied in the two-dimensional hexagonal grid and the three-dimensional cubic grid. Meanwhile, when our algorithm is applied in two-dimensional rectangular grid, it can get a discrete line which is more similar to the line in the Euclidean space.
On the application of Discrete Time Optimal Control Concepts to ...
African Journals Online (AJOL)
On the application of Discrete Time Optimal Control Concepts to Economic Problems. ... Journal of the Nigerian Association of Mathematical Physics ... Abstract. An extension of the use of the maximum principle to solve Discrete-time Optimal Control Problems (DTOCP), in which the state equations are in the form of general ...
Discretion in Student Discipline: Insight into Elementary Principals' Decision Making
Findlay, Nora M.
2015-01-01
Little research exists that examines the exercise of discretion by principals in their disciplinary decision making. This study sought to understand the application of values by principals as they engage in student disciplinary decision making within legally fixed parameters of their administrative discretion. This qualitative methodology used…
FPGA implementation of fractional-order discrete memristor chaotic ...
Indian Academy of Sciences (India)
Anitha Karthikeyan
2017-12-30
Dec 30, 2017 ... ing DDR clocks help in reducing the route delays. 7. Conclusions. In this paper, we investigated the discrete fractional- order model of a fourth-order memristor chaotic system. The discrete model is formed by transforming the dif- ferential version of the system using finite truncation method. The Lyapunov ...
On approximation of Lie groups by discrete subgroups
Indian Academy of Sciences (India)
2016-08-26
Aug 26, 2016 ... The notion of approximation of Lie groups by discrete subgroups was introduced by Tôyama in Kodai Math. Sem. Rep. 1 (1949) 36–37 and investigated in detail by Kuranishi in Nagoya Math. J. 2 (1951) 63–71. It is known as a theorem of Tôyama that any connected Lie group approximated by discrete ...
Resolving ambiguities in reconstructed grain maps using discrete tomography
DEFF Research Database (Denmark)
Alpers, A.; Knudsen, E.; Poulsen, H.F.
2005-01-01
reconstruct the image from diffraction data, but they are often unable to assign unambiguous values to all pixels. We present an approach that resolves these ambiguous pixels by using a Monte Carlo technique that exploits the discrete nature of the problem and utilizes proven methods of discrete tomography...
Discrete wavelet transforms over finite sets which are translation invariant
L. Kamstra
2001-01-01
textabstractThe discrete wavelet transform was originally a linear operator that works on signals that are modeled as functions from the integers into the real or complex numbers. However, many signals have discrete function values. This paper builds on two recent developments: the extension of
A discrete-space urban model with environmental amenities
Liaila Tajibaeva; Robert G. Haight; Stephen Polasky
2008-01-01
This paper analyzes the effects of providing environmental amenities associated with open space in a discrete-space urban model and characterizes optimal provision of open space across a metropolitan area. The discrete-space model assumes distinct neighborhoods in which developable land is homogeneous within a neighborhood but heterogeneous across neighborhoods. Open...
CDM: Teaching Discrete Mathematics to Computer Science Majors
Sutner, Klaus
2005-01-01
CDM, for computational discrete mathematics, is a course that attempts to teach a number of topics in discrete mathematics to computer science majors. The course abandons the classical definition-theorem-proof model, and instead relies heavily on computation as a source of motivation and also for experimentation and illustration. The emphasis on…
Preservation properties for the discrete mean residual life ordering
Directory of Open Access Journals (Sweden)
Abdulhakim Al-Babtain
2015-04-01
Full Text Available The purpose of this paper is to prove several preservation properties of stochastic comparisons based on the discrete mean residual life ordering d-MRL under the reliability operations of convolutions, mixtures. Fi nally we introduce a discrete renewal process application
Absolute Stability of Discrete-Time Systems with Delay
Directory of Open Access Journals (Sweden)
Medina Rigoberto
2008-01-01
Full Text Available We investigate the stability of nonlinear nonautonomous discrete-time systems with delaying arguments, whose linear part has slowly varying coefficients, and the nonlinear part has linear majorants. Based on the "freezing" technique to discrete-time systems, we derive explicit conditions for the absolute stability of the zero solution of such systems.