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Sample records for discovery opens door

  1. Technology Opens Doors to Scientific Discovery, Portrait Unveiled of Former NLM Director Lindberg | NIH MedlinePlus the ...

    Science.gov (United States)

    ... version of this page please turn JavaScript on. Technology Opens Doors to Scientific Discovery Past Issues / Spring 2016 Table of Contents Susannah Fox, chief technology officer of the U.S. Department of Health and ...

  2. Science Opens Doors

    Science.gov (United States)

    Smyth, Steve; Smyth, Jen

    2016-01-01

    Science Opens Doors is the creation of Clive Thompson of the Horners' Livery Company. The Science Opens Doors project philosophy is strongly based upon the King's College London ASPIRES project, which established that children like doing science in junior school (ages 7-11), but that by the age of 12-14 they are firmly against becoming scientists.…

  3. China opens the door

    Energy Technology Data Exchange (ETDEWEB)

    Starke, K.

    1997-01-01

    The door to China`s vast market for power generation was opened a bit further for foreign firms in November. That is when power ministry head Shi Dazhen said the country would rely on overseas investors for 20 percent of the funding needed to boost output--double the amount foreigners were previously allowed to contribute. Through 1995, foreigners invested $12.2 billion in China`s electricity industry, accounting for 10 percent of total investment. According to Shi, foreign investors will be asked to provide about $17 billion of the $84 billion China plans to invest in the sector over the next five years. Under China`s Ninth Five-Year Plan (1996-2000), the government aims to boost the country`s power generation capacity at the rate of 15,000 MW to 20,000 MW annually by the year 2000. Since China`s public external debt balance already exceeds $80 billion, however, the government would seem to have little choice but to allow foreigners a greater role. Shi also said that foreigners would be allowed 100 percent ownership of PRC power projects. This is discouraged under China`s current industry guidelines. It is, however, expected to be permitted under China`s first build-operate-transfer (BOT) law, which was anticipated by the end of 1996, says Susan Urkevich, director of project finance at HSBC Investment Bank Asia in Hong Kong. Indeed, China`s first BOT is already happening.

  4. September 2013: the doors open

    CERN Document Server

    Antonella Del Rosso

    2013-01-01

    Three special days and one public open day: at the end of September our Laboratory will open its doors to visitors from CERN, the local region and all over the world. With over 150,000 visitors expected in total, the organisation of the OpenDays is a challenge that a core team of eleven people have taken up with enthusiasm.   They come from several departments but share one goal: making the last four days of September an unforgettable experience for all the visitors who will come to discover the Laboratory and its scientists. The core team in charge of the organisation of the events is co-ordinated by Hermann Schmickler. “The events are an opportunity for us to celebrate  the discoveries, the excellent performance of the technical installations and the vital contribution of all the CERN personnel, the thousands of users and those working under support contracts,” says Hermann Schmickler. The four-day programme will start on Friday 27 September with an “...

  5. Opening Doors, Hearts and Minds

    Science.gov (United States)

    Foster, Andrea

    2007-01-01

    A panel discussion, "Opening Doors, Hearts and Minds," was hosted at the 2006 annual COEO conference. Four dedicated Torontonians shared how they interpret outdoor environmental education and environmental education in what they do and offered suggestions as to how their work might be integrated in diverse urban communities. Tafari…

  6. Opening the door to innovation.

    Science.gov (United States)

    Schuurman, Janine; Graus, Yvo F; Labrijn, Aran F; Ruuls, Sigrid; Parren, Paul W H I

    2014-01-01

    Open innovation is the new buzz, with initiatives popping up left and right. Here, we give a personal perspective on a very successful, knowledge-driven innovation initiated in an academia- industry alliance, which culminated in technology platforms that enable the generation of therapeutic antibodies with novel properties. To start, we provide a general background on open innovation in the drug development field.

  7. Opening the doors: building brand awareness.

    Science.gov (United States)

    John, Judith; McCartney, Rob

    2006-01-01

    In search of a credible and cost-effective way to promote Mount Sinai Hospital (Mount Sinai) and educate a broad public, Mount Sinai opened its doors wide to The Globe and Mail (The Globe). The result was a three-part national feature series that told Mount Sinai's compelling story, provided third-party credibility and confirmed the value of proactive media relations. The series engaged our staff, energized our volunteers and reached both stakeholders and the general public on an emotional level. It also generated the more than dollars 6 million worth of equivalent advertising space it would have required for Mount Sinai to reach this national audience.

  8. Ombuds’ corner: Open door and confidentiality

    CERN Multimedia

    Vincent Vuillemin

    2013-01-01

    For the Open Days, CERN will be transparent for all visitors. It's also the occasion to remember that the Ombuds' door is fully open every day of the year for all persons working for or on behalf of CERN.   The door is open, but as soon as it's closed for a discussion, the office becomes a place where total confidentiality is preserved. This may appear as a contradiction, no? The Ombuds is available to help everyone in all circumstances, but his clause of confidentiality prevents him from acting without the consent of his “visitors”. How can he possibly resolve the in-house conflicts in groups, or units, if all the parties do not voluntarily participate in its resolution? The answer is clear: the job of the Ombuds is to help the parties resolve their conflict by themselves. He will provide a few rules of communication, a process of mutual respect, suggest some possibilities that the parties may want to follow, and mediate the dispute so that people...

  9. Golden Jubilee Photos: Doors wide open

    CERN Document Server

    2004-01-01

    http://www.cern.ch/cern50/ The reception area and visits desk (formerly PIO - Public Information Office) in 1972. Régine Chareyron (on the right), who has worked for the Visits Service for 35 years, is pictured here with Chantal Montuel and Cora Roth. CERN inaugurated its permanent visitor centre "Microcosm" in 1989. This brand new outreach facility added a crowning touch to CERN's tradition of openness in conducting its research activities. In keeping with Article II of the Convention, which stipulates that "the results of its (...) work shall be published or otherwise made available," CERN was already organising visits for the general public in the late 1950s, with members of the personnel doubling up as voluntary tour guides. By 1959, the Laboratory was opening its doors to almost 2 500 visitors a year. Ten years down the line, that number had risen to 12 700, and today CERN welcomes some 30 000 visitors through its doors every year. In addition, the Visits Service has developed teaching packs for sc...

  10. Failure case of a garage door opener

    Directory of Open Access Journals (Sweden)

    Habib, K.

    2005-12-01

    Full Text Available A failure analysis of a garage door opener was conducted for determination of the cause of the failure. The analysis included visual inspections of broken parts as well as electron microscopy examinations of the fracture surface. The visual inspections showed that a bolt connected to the inner trolley of the garage opener assembly was initially fractured. Also, the results of electron microscopy examinations revealed that the broken bolt failed by fatigue damage phenomenon, due to alternating torsional stresses throughout 25 years of an operational life of the garage opener. In addition, a mathematical model corresponding to the failure mechanism was derived along the failure analysis. The model comprises of both design philosophy and fracture mechanics approaches.

    Se analizó el fallo del mecanismo de apertura de una puerta de garaje con el fin de determinar sus causas. El análisis incluyó una inspección visual de las piezas rotas así como un examen mediante microscopía de la superficie de fractura. La inspección visual reveló que primero se fracturó un perno conectado al carro interior del mecanismo de apertura. Los resultados del análisis por microscopía electrónica también mostraron que el perno roto falló debido a fenómenos de daño por fatiga, debido a los esfuerzos torsionales alternos a la largo de 25 años de vida en servicio del mecanismo de apertura. Por otra parte, se construyó un modelo matemático correspondiente al mecanismo de rotura durante el análisis del mismo. Este modelo comprende enfoques, tanto de la filosofía de diseño como de la mecánica de fractura.

  11. The Discovery of Arthropod-Specific Viruses in Hematophagous Arthropods: An Open Door to Understanding the Mechanisms of Arbovirus and Arthropod Evolution?

    Science.gov (United States)

    Calisher, Charles H; Higgs, Stephen

    2018-01-07

    The discovery of an odd virus from hematophagous arthropods 40 years ago by Stollar and Thomas described cell fusing agent virus in cells derived from Aedes aegypti mosquitoes. Then came the report of Kamiti River virus from Ae. macintoshi in 1999, followed by worldwide reports of the discovery of other viruses of mosquitoes, ticks, and midges that replicate only in arthropods and not in vertebrates or in vertebrate cells. These viruses (now totaling at least 64 published) have genomes analogous to viruses in various families that include arboviruses and nonarboviruses. It is likely that some of these viruses have been insufficiently studied and may yet be shown to infect vertebrates. However, there is no doubt that the vast majority are restricted to arthropods alone and that they represent a recently recognized clade. Their biology, modes of transmission, worldwide distribution (some have been detected in wild-caught mosquitoes in both Asia and the United States, for example), molecular characteristics of their genomes, and potential for becoming vertebrate pathogens, or at least serving as virus reservoirs, are fascinating and may provide evidence useful in understanding virus evolution. Because metagenomics studies of arthropods have shown that arthropod genomes are the sources of arthropod virus genomes, further studies may also provide insights into the evolution of arthropods. More recently, others have published excellent papers that briefly review discoveries of arthropod viruses and that characterize certain genomic peculiarities, but, to now, there have been no reviews that encompass all these facets. We therefore anticipate that this review is published at a time and in a manner that is helpful for both virologists and entomologists to make more sense and understanding of this recently recognized and obviously important virus group. This review focuses specifically on arthropod viruses in hematophagous arthropods.

  12. [Psychiatry with open doors. Part 1: Rational for an open door for acute psychiatry].

    Science.gov (United States)

    Sollberger, D; Lang, U E

    2014-03-01

    Despite the reform efforts of the last decades modern acute psychiatry still stands between conflicting priorities in everyday practice. The protection of patient autonomy might conflict with a regulatory mandate of psychiatry in societal contexts and the necessity of coercive measures and involuntary treatment might become problematic with respect to presumed but contentious interests of the patient. The conflicts particularly concern questions of involuntary commitment, door closing, coercive and isolation measures. Research on the topic of therapeutic effectiveness of these practices is rare. Accordingly, the practice depends on the federal state, hospital and ward and is very heterogeneous. Epidemiological prognosis predicts an increase of psychiatric disorders; however, simultaneously in terms of medical ethics the warranty of patient autonomy, shared decision-making and informed consent in psychiatry become increasingly more important. This challenges structural and practical changes in psychiatry, particularly in situations of self and third party endangerment which are outlined and a rationale for an opening of the doors in acute psychiatric wards is provided.

  13. Globalization: an open door for the knowledge economy

    Directory of Open Access Journals (Sweden)

    Andreea MARIN-PANTELESCU

    2009-12-01

    Full Text Available Globalization refers to an emphasized process of global integration and spreading a set of ideas related to the economical activity and goods’ production, the premises being the liberalization of international commerce and the capital flows, the speeding up of the technological progress and informational society. The cognitive society is more and more obvious and unanimously accepted, which actually proves its efficiency. If traditional, conservative communities, which are not open to change and reject from the start anything new on the horizon, still exist today, they are isolated cases that will eventually be "converted" by this wave of information that has become indispensable to any development because in its absence resources could not be used efficiently. Taking into consideration these elements, this paper wishes to give arguments to the fact that globalization can be seen as being an open door for the cognitive society.

  14. Characterisation of open-door electrical cabinet fires in compartments

    Energy Technology Data Exchange (ETDEWEB)

    Coutin, M., E-mail: mickael.coutin@irsn.fr; Plumecocq, W.; Zavaleta, P.; Audouin, L.

    2015-05-15

    Highlights: • Heat release rate of electrical cabinet fire source in a vitiated atmosphere. • Experimental database for proper validation the combustible modelling, taking into account the oxygen depletion in an enclosure. • New model for complex fire source. - Abstract: The study of electrical fires is a major concern for fire safety in the industry and more particularly for fire safety in nuclear facilities. To investigate this topic, IRSN conducted a large number of real-scale experiments involving open-door electrical cabinets burning firstly under a calorimetric hood and then inside a mechanically-ventilated compartment. The main challenges are to determine accurately the heat release rate of such a complex fire source in a vitiated atmosphere and to provide an experimental database for validating properly the combustible modelling, taking into account the oxygen depletion in an enclosure. After providing a detailed description of the fire scenarios and of the experimental apparatus, this paper focuses on the characteristic stages of the cabinet fire development, essentially based on the heat release rate time evolution of the fire. The effects of the confinement, of the outlet branch location, of the ventilation management and of the fire barrier on the fire source were then investigated. The reproducibility of electrical cabinet fires is also studied. A new model for complex fire source (applied in this study for open-door electrical cabinet fires) was then developed. This model was introduced in the zone code SYLVIA and the major features of the compartment fire experiments, such as characteristic heat release rate with effect of oxygen depletion and over-pressure peak were then calculated with a rather good agreement for this complex fire source (i.e. electrical cabinet)

  15. The CERN Global Network opens its doors to companies

    CERN Multimedia

    Francesco Poppi

    2010-01-01

    Six months after its launch, the CERN Global Network already has almost one thousand members. Today, it is opening its doors to companies from CERN's Member States. This will open up a variety of new professional and career opportunities to all the members and will enhance the networking capabilities of all parties involved.   Screenshot of the CERN Global Network website. A new item has recently appeared on the top menu of the Network's website: “Organisations”. This is the entry point for companies and, later, research institutes, wishing to join. “The CERN Global Network brings together hundreds of people who have worked at or with CERN and who have a wealth of skills and expertise. Thanks to the Network, the job opportunities made available by the companies will become visible to the wider community,” says Linda Orr-Easo, a member of the Knowledge and Technology Transfer Group and the CERN Global Network Manager. In addition to creating new career opp...

  16. Effect of door opening and defrost cycle on a freezer with phase change panels

    International Nuclear Information System (INIS)

    Gin, B.; Farid, M.M.; Bansal, P.K.

    2010-01-01

    An investigation into the effectiveness of phase change material (PCM) panels placed against the internal walls of a freezer to maintain stable temperatures in the presence of heat loads such as door openings, defrosting, and loss of electrical power was carried out. Temperature response was studied during loss of power, a defrost cycle lasting 30 min, and a door opening scheme of 13 door openings over an 11 h period. This PCM system has significantly decreased the rate of temperature increase inside the freezer during defrosting and power loss. Energy consumption was measured during steady operation, a defrost cycle of 30 min, and a scheme of eight door openings at 40 min intervals. It was found that heat loads caused greater energy consumption, and that the presence of PCM during defrosting and door openings resulted in slightly lower energy consumption compared to without PCM.

  17. Novel Door-opening Method for Six-legged Robots Based on Only Force Sensing

    Science.gov (United States)

    Chen, Zhi-Jun; Gao, Feng; Pan, Yang

    2017-09-01

    Current door-opening methods are mainly developed on tracked, wheeled and biped robots by applying multi-DOF manipulators and vision systems. However, door-opening methods for six-legged robots are seldom studied, especially using 0-DOF tools to operate and only force sensing to detect. A novel door-opening method for six-legged robots is developed and implemented to the six-parallel-legged robot. The kinematic model of the six-parallel-legged robot is established and the model of measuring the positional relationship between the robot and the door is proposed. The measurement model is completely based on only force sensing. The real-time trajectory planning method and the control strategy are designed. The trajectory planning method allows the maximum angle between the sagittal axis of the robot body and the normal line of the door plane to be 45º. A 0-DOF tool mounted to the robot body is applied to operate. By integrating with the body, the tool has 6 DOFs and enough workspace to operate. The loose grasp achieved by the tool helps release the inner force in the tool. Experiments are carried out to validate the method. The results show that the method is effective and robust in opening doors wider than 1 m. This paper proposes a novel door-opening method for six-legged robots, which notably uses a 0-DOF tool and only force sensing to detect and open the door.

  18. LS1 Report: As one door closes, another opens

    CERN Multimedia

    Katarina Anthony & Anaïs Schaeffer

    2014-01-01

    Across the PS complex - from Linac 2 to TT2 to the accelerator itself - teams have seen the closing of their retro-1980s entryways, and the opening of state-of-the-art access points in compliance with the highest nuclear safety standards.   One of the new PS access points. The new PS access system provides more than just doors. Designed to protect against the radiation hazards and other risks caused by machine operation, the access system will monitor who goes into each zone, check whether or not the individual has the appropriate permissions to be entering, and even stop the beam if access is attempted during beam mode. "These new points provide automatic means to check that the right people are going in and in safe circumstances," says Pierre Ninin, project leader of the PS complex safety system. "All of these checks were previously done manually, so the burden on operators has been significantly reduced." The 19 new access points were successfully insta...

  19. Experimental Studies of Wheelchair and Walker Users Passing Through Doors with Different Opening Force.

    Science.gov (United States)

    Nersveen, Jonny

    2016-01-01

    Users of walkers and users of different categories of wheelchairs tested doors with different opening force, aiming to reveal the limit that these groups of people could manage on an everyday basis. 94.7% of the wheelchair users reported that a door opening force of 30 N was acceptable, while as 92.1% of this group described 40 N as acceptable. Similarly, 100% of the walker users reported that a door opening force of 30 N was acceptable, while as 87,5% of this group described 40 N as acceptable.

  20. Assessment of operating room airflow using air particle counts and direct observation of door openings.

    Science.gov (United States)

    Teter, Jonathan; Guajardo, Isabella; Al-Rammah, Tamrah; Rosson, Gedge; Perl, Trish M; Manahan, Michele

    2017-05-01

    The role of the operating room (OR) environment has been thought to contribute to surgical site infection rates. The quality of OR air, disruption of airflow, and other factors may increase contamination risks. We measured air particulate counts (APCs) to determine if they increased in relation to traffic, door opening, and other common activities. During 1 week, we recorded APCs in 5-minute intervals and movement of health care workers. Trained observers recorded information about traffic, door openings, job title of the opener, and the reason for opening. At least 1 OR door was open during 47% of all readings. There were 13.4 door openings per hour during cases. Door opening rates ranged from 0.19-0.28 per minute. During this time, a total of 660 air measurements were obtained. The mean APCs were 9,238 particles (95% confidence interval [CI], 5,494- 12,982) at baseline and 14,292 particles (95% CI, 12,382-16,201) during surgery. Overall APCs increased 13% when either door was opened (P opening. We observed numerous instances of verbal communication and equipment movement. Improving efficiency of communication and equipment can aid in reduction of traffic. Further study is needed to examine links between microbiologic sampling, outcome data, and particulate matter to enable study of risk factors and effects of personnel movement. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  1. Open-ended and Open-door Treatment Groups for Young People with Mental Illness.

    Science.gov (United States)

    Miller, Rachel; Mason, Susan E

    2012-01-01

    The concept of open-ended groups is expanded to include an open-door model (OEOD) wherein members with severe mental illnesses, including schizophrenia disorders and bi-polar, can join, leave, and re-enter groups as their life circumstances dictate their availability and willingness for treatment. This model is grounded on the work of Schopler and Galinsky's (1984/2006) and Galinsky and Schopler's (1989) theses on the value and processes of open-ended groups and includes perspectives on mutual aid and group development. Groupwork with the OEOD format is illustrated with examples taken from a group of 79 participants diagnosed with first-episode schizophrenia/schizoaffective disorders, 40 of who had co-occurring substance abuse. Of the 79 participants in the OEOD group program, 70 (89%) remained in treatment for the maximum of 3 years. The over-all value of group treatment for this population is reviewed along with the small number of available publications on open-ended and open-door-type groups.

  2. Volunteers: the key that opens the doors for the Open Days

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    2013: the year that CERN opens its doors to the public. 2013 is also the approximate number of volunteers needed to ensure that these Open Days (JPO) go ahead smoothly. Whatever your personnel status and function, you, the volunteers, are the key without which the Laboratory’s doors could not really open. Sign up now!   1,500 of you volunteered for the LHC2008 open days to mark the inauguration of the LHC. This year, with roughly 20% more visitors expected across the CERN sites over the two days, the organisers envisage closer to 2,000 volunteers. “We will be holding a wide variety of activities across the Laboratory’s various sites,” explains Virginie Blondeau, the member of the Open Days organising team in charge of recruiting and training volunteers. “As well as guides for the experiments, we will also need volunteers to welcome and direct visitors, to help with logistics and to man the sales points, etc.” The volunteers will rec...

  3. Identity verification using computer vision for automatic garage door opening

    NARCIS (Netherlands)

    Wijnhoven, R.G.J.; With, de P.H.N.

    2011-01-01

    We present a novel system for automatic identification of vehicles as part of an intelligent access control system for a garage entrance. Using a camera in the door, cars are detected and matched to the database of authenticated cars. Once a car is detected, License Plate Recognition (LPR) is

  4. Microscopy Opening Up New Cancer Discovery Avenues

    Science.gov (United States)

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  5. Opening the door to innovation in cloud computing

    OpenAIRE

    Clohessy, Trevor; Acton, Thomas

    2013-01-01

    peer-reviewed This paper describes research-in-progress that explores the applicability and implications of cloud computing in the creation of business value through open innovation. Both the cloud computing and open innovation paradigms represent recent phenomenon and as such many unanswered questions still persist. In responding to this research gap we propose a new value creation framework which is based on a review of the literature on cloud computing, innovation, open innovation and v...

  6. Open source drug discovery--a new paradigm of collaborative research in tuberculosis drug development.

    Science.gov (United States)

    Bhardwaj, Anshu; Scaria, Vinod; Raghava, Gajendra Pal Singh; Lynn, Andrew Michael; Chandra, Nagasuma; Banerjee, Sulagna; Raghunandanan, Muthukurussi V; Pandey, Vikas; Taneja, Bhupesh; Yadav, Jyoti; Dash, Debasis; Bhattacharya, Jaijit; Misra, Amit; Kumar, Anil; Ramachandran, Srinivasan; Thomas, Zakir; Brahmachari, Samir K

    2011-09-01

    It is being realized that the traditional closed-door and market driven approaches for drug discovery may not be the best suited model for the diseases of the developing world such as tuberculosis and malaria, because most patients suffering from these diseases have poor paying capacity. To ensure that new drugs are created for patients suffering from these diseases, it is necessary to formulate an alternate paradigm of drug discovery process. The current model constrained by limitations for collaboration and for sharing of resources with confidentiality hampers the opportunities for bringing expertise from diverse fields. These limitations hinder the possibilities of lowering the cost of drug discovery. The Open Source Drug Discovery project initiated by Council of Scientific and Industrial Research, India has adopted an open source model to power wide participation across geographical borders. Open Source Drug Discovery emphasizes integrative science through collaboration, open-sharing, taking up multi-faceted approaches and accruing benefits from advances on different fronts of new drug discovery. Because the open source model is based on community participation, it has the potential to self-sustain continuous development by generating a storehouse of alternatives towards continued pursuit for new drug discovery. Since the inventions are community generated, the new chemical entities developed by Open Source Drug Discovery will be taken up for clinical trial in a non-exclusive manner by participation of multiple companies with majority funding from Open Source Drug Discovery. This will ensure availability of drugs through a lower cost community driven drug discovery process for diseases afflicting people with poor paying capacity. Hopefully what LINUX the World Wide Web have done for the information technology, Open Source Drug Discovery will do for drug discovery. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field.

    Science.gov (United States)

    Wójcikowski, Maciej; Zielenkiewicz, Piotr; Siedlecki, Pawel

    2015-01-01

    There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. The Open Drug Discovery Toolkit was developed as a free and open source tool for both computer aided drug discovery (CADD) developers and researchers. ODDT reimplements many state-of-the-art methods, such as machine learning scoring functions (RF-Score and NNScore) and wraps other external software to ease the process of developing CADD pipelines. ODDT is an out-of-the-box solution designed to be easily customizable and extensible. Therefore, users are strongly encouraged to extend it and develop new methods. We here present three use cases for ODDT in common tasks in computer-aided drug discovery. Open Drug Discovery Toolkit is released on a permissive 3-clause BSD license for both academic and industrial use. ODDT's source code, additional examples and documentation are available on GitHub (https://github.com/oddt/oddt).

  8. The influence of opening windows and doors on the natural ventilation rate of a residential building

    Science.gov (United States)

    An analysis of air exchange rates due to intentional window and door openings in a research test house located in a residential environment is presented. These data inform the development of ventilation rate control strategies as building envelopes are tightened to improve the e...

  9. The IEA's review of France's energy policy: the challenge of opening the doors

    International Nuclear Information System (INIS)

    Appert, O.

    2000-01-01

    There has been a continuity in French energy policy for several decades now - the aim to guarantee a supply of energy under reliable, economical conditions. The review, which the International Energy Agency has just conducted, notes how successful this policy has been. But it also emphasizes the need for France to open the doors of this market to the rest of Europe. (authors)

  10. Implications of China's Open-Door Policy for Families: A Family Impact Analysis

    Science.gov (United States)

    Quach, Andrew S.; Anderson, Elaine A.

    2008-01-01

    China's open-door policy (ODP) was created in 1978 as a response to the severe economic depression affecting the country after the Cultural Revolution. The policy was designed to restore China's financial status and lift the nation out of destitution. By all accounts, the ODP has been successful in improving the country's monetary condition.…

  11. The influence of opening windows and doors on the natural ventilation rate of a residential building

    Science.gov (United States)

    Increased building energy efficiency is important in reducing national energy use and greenhouse gas emissions. An analysis of air change rates due to door and window openings in a research test house located in a residential environment are presented. These data inform developme...

  12. New MAGLEV link opens door to world sales

    Energy Technology Data Exchange (ETDEWEB)

    1981-03-13

    When the magnetic levitation people mover-or advanced transit shuttle-linking Birmingham airport with the international railway station opens in 1984, it is expected to be the first revenue-earning system of its kind in the world. The project and the high hopes of its backers for future sales are discussed.

  13. Air curtain technology improves working conditions with open hall doors; Luftschleiertechnik verbessert Arbeitsbedingungen bei geoeffneten Hallentoren

    Energy Technology Data Exchange (ETDEWEB)

    Multhauf, R. [Biddle GmbH, Koeln (Germany)

    1998-11-01

    Hall doors are indispensable for short logistic distances of product or raw materials management. Air curtain systems make it possible to keep doors open independent of the weather and season. The heating energy requiremens of modern air curtain systems has been reduced significantly. (orig.) [Deutsch] Hallentore sind fuer moeglichst kurze Logistikwege der Waren oder Rohstoffe im industriellen Betrieb unvermeidlich. Luftschleieranlagen ermoeglichen offene Tore unabhaengig von der Witterung und der Jahreszeit. Die zur Betreibung der Luftschleieranlagen notwendige Heizenergie wurde durch neue Entwicklungen stark reduziert. (orig.)

  14. Metabolomics - A wide-open door to personalized treatment in chronic heart failure?

    Science.gov (United States)

    Marcinkiewicz-Siemion, M; Ciborowski, M; Kretowski, A; Musial, W J; Kaminski, K A

    2016-09-15

    Heart failure (HF) is a complex syndrome representing a final stage of various cardiovascular diseases. Despite significant improvement in the diagnosis and treatment (e.g. ACE-inhibitors, β-blockers, aldosterone antagonists, cardiac resynchronization therapy) of the disease, prognosis of optimally treated patients remains very serious and HF mortality is still unacceptably high. Therefore there is a strong need for further exploration of novel analytical methods, predictive and prognostic biomarkers and more personalized treatment. The metabolism of the failing heart being significantly impaired from its baseline state may be a future target not only for biomarker discovery but also for the pharmacologic intervention. However, an assessment of a particular, isolated metabolite or protein cannot be fully informative and makes a correct interpretation difficult. On the other hand, metabolites profile analysis may greatly assist investigator in an interpretation of the altered pathway dynamics, especially when combined with other lines of evidence (e.g. metabolites from the same pathway, transcriptomics, proteomics). Despite many prior studies on metabolism, the knowledge of peripheral and cardiac pathophysiological mechanisms responsible for the metabolic imbalance and progression of the disease is still insufficient. Metabolomics enabling comprehensive characterization of low molecular weight metabolites (e.g. lipids, sugars, organic acids, amino acids) that reflects the complete metabolic phenotype seems to be the key for further potential improvement in HF treatment (diet-based or biochemical-based). Will this -omics technique one day open a door to easy patients identification before they have a heart failure onset or its decompensation? Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. "On the gate of Arctic": Doors open to foreign schools

    Science.gov (United States)

    Pecchiar, Irene

    2015-04-01

    With the increased attention to the changing of the Arctic Region as a consequence of global climate changes, effective science education, outreach and communication need to be higher priorities within the scientific communities. In order to encourage the dissemination of polar research at educational levels Slovene high school students in Trieste were first engaged at school and at the National Museum of Antarctica of Trieste using conferences and laboratory activities to introduce the main polar climate change topics. Then together with three teachers they visited Tromso University (North Norway) for a week. The first aim of this project was to increase awareness of foreign schools on major topics concerning the Arctic issues (from the economic/social to the environmental/climatic point of view). Forty-three high school students were involved in the laboratory activities running at the University of Tromso and participated in seminars. The topics focused on were Ocean Acidification, Global Warming and the combined effects with other anthropogenic stressors. During their stay, students interviewed several scientists in order to allow them to edit a »visiting report«, that was updated every day in their blog and to elaborate all the material collected (photos, videos, data of laboratory work, reports). In Tromso, they were also introduced to the culture and tradition of the Scandinavian indigenous people at the Center of Sami Study. Back in Italy, they published some articles in local newspapers, and then they presented their results at the National Museum of Antarctica of Trieste about all the data elaboration in an open day exhibition with posters, short movies and PowerPoint presentations. All this work was made in order to pass their experience into the world. This was a pilot project, highlighting the role of universities as links between research and outreach. The next step should be to enlarge these kinds of activities to many Schools, Universities and

  16. [Three dimensional finite element model of a modified posterior cervical single open-door laminoplasty].

    Science.gov (United States)

    Wang, Q; Yang, Y; Fei, Q; Li, D; Li, J J; Meng, H; Su, N; Fan, Z H; Wang, B Q

    2017-06-06

    Objective: To build a three-dimensional finite element models of a modified posterior cervical single open-door laminoplasty with short-segmental lateral mass screws fusion. Methods: The C(2)-C(7) segmental data were obtained from computed tomography (CT) scans of a male patient with cervical spondylotic myelopathy and spinal stenosis.Three-dimensional finite element models of a modified cervical single open-door laminoplasty (before and after surgery) were constructed by the combination of software package MIMICS, Geomagic and ABAQUS.The models were composed of bony vertebrae, articulating facets, intervertebral disc and associated ligaments.The loads of moments 1.5Nm at different directions (flexion, extension, lateral bending and axial rotation)were applied at preoperative model to calculate intersegmental ranges of motion.The results were compared with the previous studies to verify the validation of the models. Results: Three-dimensional finite element models of the modified cervical single open- door laminoplasty had 102258 elements (preoperative model) and 161 892 elements (postoperative model) respectively, including C(2-7) six bony vertebraes, C(2-3)-C(6-7) five intervertebral disc, main ligaments and lateral mass screws.The intersegmental responses at the preoperative model under the loads of moments 1.5 Nm at different directions were similar to the previous published data. Conclusion: Three-dimensional finite element models of the modified cervical single open- door laminoplasty were successfully established and had a good biological fidelity, which can be used for further study.

  17. Visually and force controlled opening and closing of doors by means of a mobile robot arm

    OpenAIRE

    Milighetti, G.; Hoffmann, E.; Fetzner, Angelika; Kuntze, Helge-Björn

    2012-01-01

    A multi-sensory discrete-continuous control concept has been developed to realize interactive basic skills for humanoid and mobile service robots. In the upper hierarchy level a discrete task control structure enables the flexible execution of primitive skill sequences. In the lower continuous level a suitable controller is chosen with control parameters adapted to the current primitive skill. The basic skill for the frequently occurring task of unlocking and opening a door by means of a mobi...

  18. Opening Doors.

    Science.gov (United States)

    Turner, James S.

    1990-01-01

    Presents five teachers' narratives about their learning experiences during sabbatical leaves funded by the National Endowment for the Humanities/Reader's Digest Teacher-Scholars program. Stresses insights to be incorporated into their teaching methods in English and Black literature, children's literature, Chinese culture, and the history of the…

  19. LRO-LAMP failsafe door-open performance: improving FUV measurements of dayside lunar hydration

    Science.gov (United States)

    Davis, Michael W.; Greathouse, Thomas K.; Kaufmann, David E.; Retherford, Kurt D.; Versteeg, Maarten H.

    2017-08-01

    The Lunar Reconnaissance Orbiter's (LRO) Lyman Alpha Mapping Project (LAMP) is a lightweight (6.1 kg), lowpower (4.5 W), ultraviolet spectrograph based on the Alice instruments aboard the European Space Agency's Rosetta spacecraft and NASA's New Horizons spacecraft. Its primary job is to identify and localize exposed water frost in permanently shadowed regions (PSRs) near the Moon's poles, and to characterize landforms and albedos in PSRs. LRO launched on June 18, 2009 and reached lunar orbit four days later. LAMP operated with its failsafe door closed for its first seven years in flight. The failsafe door was opened in October 2016 to increase light throughput during dayside operations at the expense of no longer having the capacity to take further dark observations and slightly more operational complexity to avoid saturating the instrument. This one-time irreversible operation was approved after extensive review, and was conducted flawlessly. The increased throughput allows measurement of dayside hydration in one orbit, instead of averaging multiple orbits together to reach enough signal-to-noise. The new measurement mode allows greater time resolution of dayside water migration for improved investigations into the source and loss processes on the lunar surface. LAMP performance and optical characteristics after the failsafe door opening are described herein, including the new effective area, wavelength solution, and resolution.

  20. Numerical modeling of cold room's hinged door opening and closing processes

    Science.gov (United States)

    Carneiro, R.; Gaspar, P. D.; Silva, P. D.; Domingues, L. C.

    2016-06-01

    The need of rationalize energy consumption in agrifood industry has fasten the development of methodologies to improve the thermal and energy performances of cold rooms. This paper presents a three-dimensional (3D) transient Computational Fluid Dynamics (CFD) modelling of a cold room to evaluate the air infiltration rate through hinged doors. A species transport model is used for modelling the tracer gas concentration decay technique. Numerical predictions indicate that air temperature difference between spaces affects the air infiltration. For this case study, the infiltration rate increases 0.016 m3 s-1 per K of air temperature difference. The knowledge about the evolution of air infiltration during door opening/closing times allows to draw some conclusions about its influence on the air conditions inside the cold room, as well as to suggest best practices and simple technical improvements that can minimize air infiltration, and consequently improve thermal performance and energy consumption rationalization.

  1. Quality of life in symptomatic cervical myelopathy after open-door laminoplasty

    Directory of Open Access Journals (Sweden)

    Rodrigo Yuiti Nakao

    2015-06-01

    Full Text Available OBJECTIVE: To analyze the results obtained by open-door laminoplasty using the Newbridge(r/Blackstone plate, in cases of myelopathy associated with cervical lordosis.METHODS: From December 2010 to October 2012, eight patients between the ages of 49 and 68 underwent open-door laminoplasty with the use of the Newbridge(r fixation system for maintenance and stabilization of the cervical laminoplasty. Minimum follow-up was four months. For the evaluation of quality of life the questionnaire SF-36 was applied at the following times: preoperative, one month and three months after surgery associated with the subjective assessment of the patient regarding satisfaction with the procedure and with the Nurick neurological scale applied prior to surgery and three months later.RESULTS: According to the SF-36, there was significant improvement in the domains functional ability, general health perceptions and emotional aspects over time; regarding physical limitations and social aspects there was no improvement in the first postoperative month, only in the third month. There were no statistically significant changes observed during the period covered by this study related to pain, vitality and mental health. According to Nurick scale, there was evidence of improvement in symptoms of cervical myelopathy. Based on the subjective evaluation of the patients, surprisingly, all patients were satisfied with the surgical procedure and the results.CONCLUSION: The open-door laminoplasty technique with rigid fixation to maintain the opening is useful in improving the symptoms of cervical myelopathy associated with lordosis, leading to improved quality of life and with a high degree of patient satisfaction and fewer complications.

  2. Hamming's "open doors" and group creativity as keys to scientific excellence: the example of Cambridge.

    Science.gov (United States)

    Erren, Thomas C

    2008-01-01

    Dr. Charlton used diverse approaches to identify research institutions which provided home to outstanding scientists and work. One intriguing example of long-lasting scientific excellence is Cambridge with 19 Nobel laureates who worked at the University or at the MRC Molecular Biology Unit when they received the prize between 1947 and 2006. With specific reference to Cambridge, I would like to complement the primarily quantitative assessment and offer considerations as to why and how research achievements may have clustered in space and time. Indeed, observations voiced by the mathematician Richard Hamming as to how great research can be pursued offer explanations for the series of great science in the UK. In my view, the most important determinant of the clustering may be illustrated by Hamming's fitting picture of "open doors": working in environments with the doors open allows constant interactions with peers with various disciplinary backgrounds, and thus fast avoidance of detours or dead ends in science and, ultimately, a focus on and the solution of problems of paramount, rather than of tangential, importance. Narrative insights into a strong argumentative tradition at Cambridge provided by Drs. Watson and Magueijo between 1968 and 2003 are in line with Hamming's suggestion and the value of group creativity. In the internet age with abundant interactions beyond home institutions we should not be surprised if clusters of great science were no longer confined to the usual suspect institutions which were awarded disproportionally with Nobel prizes in the past.

  3. Opening Doors to Recovery: Recidivism and Recovery Among Persons With Serious Mental Illnesses and Repeated Hospitalizations.

    Science.gov (United States)

    Compton, Michael T; Kelley, Mary E; Pope, Alicia; Smith, Kelly; Broussard, Beth; Reed, Thomas A; DiPolito, June A; Druss, Benjamin G; Li, Charles; Lott Haynes, Nora

    2016-02-01

    Repeated hospitalizations and arrests or incarcerations diminish the ability of individuals with serious mental illnesses to pursue recovery. Community mental health systems need new models to address recidivism as well as service fragmentation, lack of engagement by local stakeholders, and poor communication between mental health providers and the police. This study examined the initial effects on institutional recidivism and measures of recovery among persons enrolled in Opening Doors to Recovery, an intensive, team-based community support program for persons with mental illness and a history of inpatient psychiatric recidivism. A randomized controlled trial of the model is underway. The number of hospitalizations, days hospitalized, and arrests (all from state administrative sources) in the year before enrollment and during the first 12 months of enrollment in the program were compared. Longitudinal trajectories of recovery-using three self-report and five clinician-rated measures-were examined. Analyses accounted for baseline symptom severity and intensity of involvement in the program. One hundred participants were enrolled, and 72 were included in the analyses. Hospitalizations decreased, from 1.9±1.6 to .6±.9 (precovery measures, and trajectories of improvement were apparent across the entire follow-up period. Opening Doors to Recovery holds promise as a new service approach for reducing hospital recidivism and promoting recovery in community mental health systems and is deserving of further controlled testing.

  4. Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders.

    Science.gov (United States)

    Han, Chanshuai; Chaineau, Mathilde; Chen, Carol X-Q; Beitel, Lenore K; Durcan, Thomas M

    2018-01-01

    Neurodegenerative diseases are a challenge for drug discovery, as the biological mechanisms are complex and poorly understood, with a paucity of models that faithfully recapitulate these disorders. Recent advances in stem cell technology have provided a paradigm shift, providing researchers with tools to generate human induced pluripotent stem cells (iPSCs) from patient cells. With the potential to generate any human cell type, we can now generate human neurons and develop "first-of-their-kind" disease-relevant assays for small molecule screening. Now that the tools are in place, it is imperative that we accelerate discoveries from the bench to the clinic. Using traditional closed-door research systems raises barriers to discovery, by restricting access to cells, data and other research findings. Thus, a new strategy is required, and the Montreal Neurological Institute (MNI) and its partners are piloting an "Open Science" model. One signature initiative will be that the MNI biorepository will curate and disseminate patient samples in a more accessible manner through open transfer agreements. This feeds into the MNI open drug discovery platform, focused on developing industry-standard assays with iPSC-derived neurons. All cell lines, reagents and assay findings developed in this open fashion will be made available to academia and industry. By removing the obstacles many universities and companies face in distributing patient samples and assay results, our goal is to accelerate translational medical research and the development of new therapies for devastating neurodegenerative disorders.

  5. Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders

    Directory of Open Access Journals (Sweden)

    Chanshuai Han

    2018-02-01

    Full Text Available Neurodegenerative diseases are a challenge for drug discovery, as the biological mechanisms are complex and poorly understood, with a paucity of models that faithfully recapitulate these disorders. Recent advances in stem cell technology have provided a paradigm shift, providing researchers with tools to generate human induced pluripotent stem cells (iPSCs from patient cells. With the potential to generate any human cell type, we can now generate human neurons and develop “first-of-their-kind” disease-relevant assays for small molecule screening. Now that the tools are in place, it is imperative that we accelerate discoveries from the bench to the clinic. Using traditional closed-door research systems raises barriers to discovery, by restricting access to cells, data and other research findings. Thus, a new strategy is required, and the Montreal Neurological Institute (MNI and its partners are piloting an “Open Science” model. One signature initiative will be that the MNI biorepository will curate and disseminate patient samples in a more accessible manner through open transfer agreements. This feeds into the MNI open drug discovery platform, focused on developing industry-standard assays with iPSC-derived neurons. All cell lines, reagents and assay findings developed in this open fashion will be made available to academia and industry. By removing the obstacles many universities and companies face in distributing patient samples and assay results, our goal is to accelerate translational medical research and the development of new therapies for devastating neurodegenerative disorders.

  6. Through the Open Door--Today's Revolution in Open Access and Distance Learning.

    Science.gov (United States)

    Bennett, Roger, Ed.

    1986-01-01

    Consists of eight articles discussing the topic of open learning. Articles address (1) definitions, (2) corporate training, (3) further education programs, (4) university-based training, (5) distance learning, (6) learning to learn, (7) Britain's Open University, (8) the Business-Technical Education Council. (CH)

  7. Closed windows, open doors: geopolitics and post-1949 Mainland Chinese immigration to Canada.

    Science.gov (United States)

    Liu X-f; Norcliffe, G

    1996-01-01

    "Since 1949 there have been dramatic changes in the flow of migrants from Mainland China to Canada, which existing structural models of migration, emphasizing factors in the destination country, do not fully capture. Conditions in the country of origin, and geopolitical relationships between China and Canada, played a decisive role in this migration.... Changing geopolitical circumstances led China to develop an open-door policy between 1973 and 1989, leading to increasing flows of migrants to Canada. The political response in Canada to the Tiananmen Square massacre of 1989 was to allow all Chinese students and workers in Canada to stay, if they so wished.... The result was a large inflow making MCIS the third-largest group of immigrants to Canada in the early 1990s." (EXCERPT)

  8. The effect of laminar air flow and door openings on operating room contamination.

    Science.gov (United States)

    Smith, Eric B; Raphael, Ibrahim J; Maltenfort, Mitchell G; Honsawek, Sittisak; Dolan, Kyle; Younkins, Elizabeth A

    2013-10-01

    We evaluate the association of laminar airflow (LAF) and OR traffic with intraoperative contamination rates. Two sterile basins were placed in each room during 81 cases, one inside and one outside the LAF. One Replicate Organism Detection and Counting (RODAC) plate from each basin was sent for culture at successive 30-minute intervals from incision time until wound closure. At successive 30-minute intervals more plates were contaminated outside than inside the LAF. A negative binomial model showed that the bacteria colony forming units (CFU) depended on whether there were any door openings (P=0.02) and the presence of LAF (P=0.003). LAF decreases CFU by 36.6%. LAF independently reduces the risk of contamination and microbial counts for surgeries lasting 90 minutes or less. © 2013.

  9. Opening the Doors to Knowledge: Rebus’ Collaborative Publishing Model for Open Textbooks

    OpenAIRE

    Ashok, Apurva

    2017-01-01

    Over the last thirty years, the cost of education has become prohibitively expensive, both in terms of tuition and with reference to rising textbook costs. In response, organizations such as the Rebus Foundation are working towards the development of scalable models of Open Textbook creation. This report outlines, examines, and critiques Rebus’ efforts. It historicizes the Open Education Movement, and delineates Rebus’ role within the current textbook publishing landscape. Concentrating on th...

  10. Open discovery: An integrated live Linux platform of Bioinformatics tools.

    Science.gov (United States)

    Vetrivel, Umashankar; Pilla, Kalabharath

    2008-01-01

    Historically, live linux distributions for Bioinformatics have paved way for portability of Bioinformatics workbench in a platform independent manner. Moreover, most of the existing live Linux distributions limit their usage to sequence analysis and basic molecular visualization programs and are devoid of data persistence. Hence, open discovery - a live linux distribution has been developed with the capability to perform complex tasks like molecular modeling, docking and molecular dynamics in a swift manner. Furthermore, it is also equipped with complete sequence analysis environment and is capable of running windows executable programs in Linux environment. Open discovery portrays the advanced customizable configuration of fedora, with data persistency accessible via USB drive or DVD. The Open Discovery is distributed free under Academic Free License (AFL) and can be downloaded from http://www.OpenDiscovery.org.in.

  11. OPENING REMARKS: SciDAC: Scientific Discovery through Advanced Computing

    Science.gov (United States)

    Strayer, Michael

    2005-01-01

    Good morning. Welcome to SciDAC 2005 and San Francisco. SciDAC is all about computational science and scientific discovery. In a large sense, computational science characterizes SciDAC and its intent is change. It transforms both our approach and our understanding of science. It opens new doors and crosses traditional boundaries while seeking discovery. In terms of twentieth century methodologies, computational science may be said to be transformational. There are a number of examples to this point. First are the sciences that encompass climate modeling. The application of computational science has in essence created the field of climate modeling. This community is now international in scope and has provided precision results that are challenging our understanding of our environment. A second example is that of lattice quantum chromodynamics. Lattice QCD, while adding precision and insight to our fundamental understanding of strong interaction dynamics, has transformed our approach to particle and nuclear science. The individual investigator approach has evolved to teams of scientists from different disciplines working side-by-side towards a common goal. SciDAC is also undergoing a transformation. This meeting is a prime example. Last year it was a small programmatic meeting tracking progress in SciDAC. This year, we have a major computational science meeting with a variety of disciplines and enabling technologies represented. SciDAC 2005 should position itself as a new corner stone for Computational Science and its impact on science. As we look to the immediate future, FY2006 will bring a new cycle to SciDAC. Most of the program elements of SciDAC will be re-competed in FY2006. The re-competition will involve new instruments for computational science, new approaches for collaboration, as well as new disciplines. There will be new opportunities for virtual experiments in carbon sequestration, fusion, and nuclear power and nuclear waste, as well as collaborations

  12. Open Access, Education Research, and Discovery

    Science.gov (United States)

    Furlough, Michael

    2010-01-01

    Background/Context: The open access movement has successfully drawn attention to economic and political aspects of scholarly communication through a significant body of commentary that debates the merits of open access and the potential damage it may do to scholarly publishing. Researchers within the field of education research, notably John…

  13. Open PHACTS: Semantic interoperability for drug discovery

    NARCIS (Netherlands)

    William, A.J; Harland, L; Groth, P.T.; Pettifier, S; Christine, C; Willighagen, E.L; Evelo, C.T.; Blomberg, N; Ecker, G.; Goble, C.A.; Mons, B

    2012-01-01

    Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies.

  14. Opening the Door to the American Dream: Increasing Higher Education Access and Success for Immigrants. New York Fact Sheet

    Science.gov (United States)

    Erisman, Wendy; Looney, Shannon

    2008-01-01

    This fact sheet presents a snapshot of important facts that are specific to the state of New York from the "Opening the Door to the American Dream: Increasing Higher Education Access and Success for Immigrants" report, which exposes systemic barriers that prevent immigrants from entering college and/or completing bachelor's degrees…

  15. OPENING REMARKS: Scientific Discovery through Advanced Computing

    Science.gov (United States)

    Strayer, Michael

    2006-01-01

    as the national and regional electricity grid, carbon sequestration, virtual engineering, and the nuclear fuel cycle. The successes of the first five years of SciDAC have demonstrated the power of using advanced computing to enable scientific discovery. One measure of this success could be found in the President’s State of the Union address in which President Bush identified ‘supercomputing’ as a major focus area of the American Competitiveness Initiative. Funds were provided in the FY 2007 President’s Budget request to increase the size of the NERSC-5 procurement to between 100-150 teraflops, to upgrade the LCF Cray XT3 at Oak Ridge to 250 teraflops and acquire a 100 teraflop IBM BlueGene/P to establish the Leadership computing facility at Argonne. We believe that we are on a path to establish a petascale computing resource for open science by 2009. We must develop software tools, packages, and libraries as well as the scientific application software that will scale to hundreds of thousands of processors. Computer scientists from universities and the DOE’s national laboratories will be asked to collaborate on the development of the critical system software components such as compilers, light-weight operating systems and file systems. Standing up these large machines will not be business as usual for ASCR. We intend to develop a series of interconnected projects that identify cost, schedule, risks, and scope for the upgrades at the LCF at Oak Ridge, the establishment of the LCF at Argonne, and the development of the software to support these high-end computers. The critical first step in defining the scope of the project is to identify a set of early application codes for each leadership class computing facility. These codes will have access to the resources during the commissioning phase of the facility projects and will be part of the acceptance tests for the machines. Applications will be selected, in part, by breakthrough science, scalability, and

  16. Open Source Opens Doors: Repurposing Library Software to Facilitate Faculty Research and Collaboration

    Directory of Open Access Journals (Sweden)

    Sandra L. Stump

    2013-10-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Asked to convert a faculty-created Microsoft Word document of biblical references found within popular films into a searchable database for scholars, the Albright College library staff helped create a multi-access database called Bible in the Reel World. The database relied on student workers for inputting data, used MARC standard formatting for future portability, and encouraged interactive feedback, enabling scholars to submit comments and suggest additional films and references. Using the open source integrated library system Koha, MarcEdit software, and free record exporting from IMDb, library staff created a fully-searchable database for researchers and scholars to examine the use of scripture in popular film.

  17. Surgical results of open-door laminoplasty for cervical cord injury without fracture or dislocation

    International Nuclear Information System (INIS)

    Hamada, Kenichiro; Oda, Takenori; Kobashi, Masumi; Yamamura, Mitsuyoshi; Tsukamoto, Yasunori; Suzuki, Shozo; Fujita, Satoru; Mori, Shigeki; Fujiwara, Keiju

    2003-01-01

    The purpose of this study is to evaluate the efficacy of spinal cord decompression surgery for cervical spinal cord injury without fracture or dislocation of the spinal column. Twenty-nine patients treated by expansive open-door laminoplasty are the subjects to this study. Severity of neurological deficit was assessed by the Japanese Orthopaedic Association (JOA) scoring system. Therapeutic outcome was evaluated by the recovery rate of JOA score. Seventeen patients were treated by surgically during the acute phase (within three months after injury), and the remaining 12 were in chronic phase (after 3 months). The recovery rate showed no significant difference between the two groups (46.9% vs. 34.0%). In 16 patients, the lesion responsible for spinal cord damage was recognized as a change of the intramedullary signal intensity on MRI, which was most frequently located at C3/4 level. In 7 out of the 16 patients, the most stenotic level agreed with recognized cord injury on MRI, and in the remaining 9 patients, it did not. The recovery rate showed no significant difference between the two groups (57.3% vs. 31.1%). Even if the neurological dysfunction has been present more than 3 months and spontaneous improvement reaches plateau, or spinal cord injury level recognized as a signal intensity change on MRI is not stenotic, there is still some possibility for improving the neurological function through surgery. (author)

  18. The Midterm Surgical Outcome of Modified Expansive Open-Door Laminoplasty

    Directory of Open Access Journals (Sweden)

    Kuang-Ting Yeh

    2016-01-01

    Full Text Available Laminoplasty is a standard technique for treating patients with multilevel cervical spondylotic myelopathy. Modified expansive open-door laminoplasty (MEOLP preserves the unilateral paraspinal musculature and nuchal ligament and prevents facet joint violation. The purpose of this study was to elucidate the midterm surgical outcomes of this less invasive technique. We retrospectively recruited 65 consecutive patients who underwent MEOLP at our institution in 2011 with at least 4 years of follow-up. Clinical conditions were evaluated by examining neck disability index, Japanese Orthopaedic Association (JOA, Nurick scale, and axial neck pain visual analog scale scores. Sagittal alignment of the cervical spine was assessed using serial lateral static and dynamic radiographs. Clinical and radiographic outcomes revealed significant recovery at the first postoperative year and still exhibited gradual improvement 1–4 years after surgery. The mean JOA recovery rate was 82.3% and 85% range of motion was observed at the final follow-up. None of the patients experienced aggravated or severe neck pain 1 year after surgery or showed complications of temporary C5 nerve palsy and lamina reclosure by the final follow-up. As a less invasive method for reducing surgical dissection by using various modifications, MEOLP yielded satisfactory midterm outcomes.

  19. Modified expansive open-door laminoplasty technique improved postoperative neck pain and cervical range of motion.

    Science.gov (United States)

    Yeh, Kuang-Ting; Chen, Ing-Ho; Yu, Tzai-Chiu; Liu, Kuan-Lin; Peng, Cheng-Huan; Wang, Jen-Hung; Lee, Ru-Ping; Wu, Wen-Tien

    2015-12-01

    Expansive open-door laminoplasty (EOLP) is a useful technique for multiple-level cervical spondylotic myelopathy. The common postoperative complications of EOLP include moderate to severe neck pain, loss of cervical lordosis, decrease of cervical range of motion, and C5 palsy. We modified the surgical technique to lessen these complications. This study is aimed to elucidate the efficacy of modified techniques to lessen the complications of traditional procedures. We collected data from 126 consecutive patients treated at our institution between August 2008 and December 2012. Of these, 66 patients underwent conventional EOLP (CEOLP) and the other 60 patients underwent modified EOLP (MEOLP). The demographic and preoperative data, axial pain visual analog scale scores at 2 weeks and 3 months postoperatively, clinical outcomes evaluated using Nurick score and Japanese Orthopedic Association recovery rate at 12 months postoperatively, and radiographic results assessed using plain films at 3 months and 12 months postoperatively for both groups were compared and analyzed. There were no significant differences regarding the preoperative condition between the CEOLP and MEOLP groups (p > 0.05). The Japanese Orthopedic Association recovery rate of the MEOLP group was 70.3%, comparable to the result of the other group (70.2%). Postoperative axial neck pain, loss of range of motion, and loss of lordosis of cervical curvature decreased significantly in the MEOLP group (p cervical spondylotic myelopathy, which decreases postoperative complications effectively. Copyright © 2014. Published by Elsevier B.V.

  20. The case for open-source software in drug discovery.

    Science.gov (United States)

    DeLano, Warren L

    2005-02-01

    Widespread adoption of open-source software for network infrastructure, web servers, code development, and operating systems leads one to ask how far it can go. Will "open source" spread broadly, or will it be restricted to niches frequented by hopeful hobbyists and midnight hackers? Here we identify reasons for the success of open-source software and predict how consumers in drug discovery will benefit from new open-source products that address their needs with increased flexibility and in ways complementary to proprietary options.

  1. Autonomous urban reconnaissance ingress system (AURIS): providing a tactically relevant autonomous door-opening kit for unmanned ground vehicles

    Science.gov (United States)

    Shane, David J.; Rufo, Michael A.; Berkemeier, Matthew D.; Alberts, Joel A.

    2012-06-01

    The Autonomous Urban Reconnaissance Ingress System (AURIS™) addresses a significant limitation of current military and first responder robotics technology: the inability of reconnaissance robots to open doors. Leveraging user testing as a baseline, the program has derived specifications necessary for military personnel to open doors with fielded UGVs (Unmanned Ground Vehicles), and evaluates the technology's impact on operational mission areas: duration, timing, and user patience in developing a tactically relevant, safe, and effective system. Funding is provided through the US ARMY Tank Automotive Research, Development and Engineering Center (TARDEC) and the project represents a leap forward in perception, autonomy, robotic implements, and coordinated payload operation in UGVs. This paper describes high level details of specification generation, status of the last phase of development, an advanced view of the system autonomy capability, and a short look ahead towards the ongoing work on this compelling and important technology.

  2. From anonymity to "open doors": IRB responses to tensions with researchers.

    Science.gov (United States)

    Klitzman, Robert

    2012-07-03

    Tensions between IRBs and researchers in the US and elsewhere have increased, and may affect whether, how, and to what degree researchers comply with ethical guidelines. Yet whether, how, when, and why IRBs respond to these conflicts have received little systematic attention. I contacted 60 US IRBs (every fourth one in the list of the top 240 institutions by NIH funding), and interviewed leaders from 34 (response rate = 55%) and an additional 12 members and administrators. IRBs often try to respond to tensions with researchers and improve relationships in several ways, but range widely in how, when, and to what degree (e.g., in formal and informal structure, content, and tone of interactions). IRBs varied from open and accessible to more distant and anonymous, and in the amount and type of "PR work" and outreach they do. Many boards seek to improve the quantity, quality, and helpfulness of communication with PIs, but differ in how. IRBs range in meetings from open to closed, and may have clinics and newsletters. Memos can vary in helpfulness and tone (e.g., using "charm"). IRBs range considerably, too, in the degrees to which they seek to educate PIs, showing them the underlying ethical principles. But these efforts take time and resources, and IRBs thus vary in degrees of responses to PI complaints. This study, the first to explore the mechanisms through which IRBs respond to tensions and interactions with PIs, suggests that these committees seek to respond to conflicts with PIs in varying ways - both formal and informal, involving both the form and content of communications. This study has important implications for future practice, research, and policy, suggesting needs for increased attention to not only what IRBs communicate to PIs, but how (i.e., the tone and the nature of interactions). IRBs can potentially improve relationships with PIs in several ways: using more "open doors" rather than anonymity, engaging in outreach (e.g., through clinics), enhancing

  3. A Comparison of Implants Used in Open-Door Laminoplasty: Structural Rib Allografts Versus Metallic Miniplates.

    Science.gov (United States)

    Tabaraee, Ehsan; Mummaneni, Praveen; Abdul-Jabbar, Amir; Shearer, David; Roy, Esha; Amin, Beejal; Ames, Christopher; Burch, Shane; Deviren, Vedat; Berven, Sigurd; Hu, Serena; Chou, Dean; Tay, Bobby K

    2017-06-01

    A retrospective case-controlled study. Open-door laminoplasty has been successfully used to address cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament. Two common implants include rib allograft struts and metallic miniplates. The goals of this study were to compare outcomes, complications, and costs associated with these 2 implants. A retrospective review was done on 51 patients with allograft struts and 55 patients with miniplates. Primary outcomes were neck visual analog scale (VAS) pain scores and Nurick scores. Secondary outcomes included length of the procedure, estimated blood loss, rates of complications, and the direct costs associated with the surgery and inpatient hospitalization. There were no differences in demographic characteristics, diagnoses, comorbidities, and preoperative outcome scores between the 2 treatment groups. Mean follow-up was 27 months. The postoperative neck VAS scores and Nurick scores improved significantly from baseline to final follow-up for both groups, but there was no difference between the 2 groups. The average length of operation (161 vs. 136 min) and number of foraminotomies (2.7 vs. 1.3) were higher for the allograft group (P=0.007 and 0.0001, respectively). Among the miniplate group, there was no difference in complications but a trend for less neck pain for patients treated without hard collar at final follow-up (1.8 vs. 2.3, P=0.52). The mean direct costs of hospitalization for the miniplate group were 15% higher. Structural rib allograft struts and metallic miniplates result in similar improvements in pain and functional outcome scores with no difference in the rate of complications in short-term follow-up. Potential benefits of using a plate include shorter procedure length and less need for postoperative immobilization. When costs of bracing and operative time are included, the difference in cost between miniplates and allograft struts is negligible.

  4. [The psychiatric revolution in Quebec, 1950-1962. From asylum to community psychiatry and the open door].

    Science.gov (United States)

    Duprey, Catherine

    2011-01-01

    Psychiatry opens to the world at a time when the very basis of psychiatric practice, namely the asylum, is called into question. Studies appear in Quebec and Canadian journals concurrent to the introduction of new formulas for care, such as the delivery of psychiatric services in general hospitals and clinics, that allow patients to be treated outside the walls of psychiatric hospitals. In addition, postwar psychiatry takes an optimistic view toward the future of children with impairments through the creation of specialized schools and workshops. From the mid-20th century onward, the thinking in psychiatry centres on the open door.

  5. The ICTJA-CSIC Science Week 2016: an open door to Earth Sciences for secondary education students

    Science.gov (United States)

    Cortes-Picas, Jordi; Diaz, Jordi; Fernandez-Turiel, Jose-Luis; Garcia-Castellanos, Daniel; Geyer, Adelina; Jurado, Maria-Jose; Montoya, Encarni; Rejas Alejos, Marta; Sánchez-Pastor, Pilar; Valverde-Perez, Angel

    2017-04-01

    The Science Week is one of the main scientific outreach events every year in Spain. The Institute of Earth Sciences Jaume Almera of CSIC (ICTJA-CSIC) participates in it since many years ago, opening its doors and proposing several activities in which it is shown what kind of multidisciplinary research is being developed at the Institute and in Geosciences. The activities,developed as workshops, are designed and conducted by scientific and technical personnel of the centre, who participates in the Science Week voluntarily. The activities proposed by the ICTJA-CSIC staff are designed for a target audience composed by secondary school students (12-18 years). The ICTJA-CSIC joined Science Week 2016 in the framework of the activity entitled "What we investigate in Earth Sciences?". The aim is to show to the society what is being investigated in the ICTJA-CSIC. In addition, it is intended, with the contact and interaction between the public and the institute researchers, to increase the interest in scientific activity and, if possible, to generate new vocations in the field of the Earth Sciences among secondary school pupils. We show in this communication the experience of the Science Week 2016 at the ICTJA-CSIC, carried out with the effort and commitment of the of the Institute's personnel with the outreach of Earth Sciences research. Between November 14th and 19th 2016, more than 100 students from four secondary schools from Barcelona area visited the Institute and took part in the Science Week. A total of six interactive workshops were prepared showing different features of seismology, geophysical borehole logging, analog and digital modelling, paleoecology, volcanology and geochemistry. As a novelty, this year a new workshop based on an augmented reality sandbox was offered to show and to simulate the processes of creation and evolution of the topographic relief. In addition, within the workshop dedicated to geophysical borehole logging, six exact replicates of

  6. Discovery and Reuse of Open Datasets: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Sara

    2016-07-01

    Full Text Available Objective: This article analyzes twenty cited or downloaded datasets and the repositories that house them, in order to produce insights that can be used by academic libraries to encourage discovery and reuse of research data in institutional repositories. Methods: Using Thomson Reuters’ Data Citation Index and repository download statistics, we identified twenty cited/downloaded datasets. We documented the characteristics of the cited/downloaded datasets and their corresponding repositories in a self-designed rubric. The rubric includes six major categories: basic information; funding agency and journal information; linking and sharing; factors to encourage reuse; repository characteristics; and data description. Results: Our small-scale study suggests that cited/downloaded datasets generally comply with basic recommendations for facilitating reuse: data are documented well; formatted for use with a variety of software; and shared in established, open access repositories. Three significant factors also appear to contribute to dataset discovery: publishing in discipline-specific repositories; indexing in more than one location on the web; and using persistent identifiers. The cited/downloaded datasets in our analysis came from a few specific disciplines, and tended to be funded by agencies with data publication mandates. Conclusions: The results of this exploratory research provide insights that can inform academic librarians as they work to encourage discovery and reuse of institutional datasets. Our analysis also suggests areas in which academic librarians can target open data advocacy in their communities in order to begin to build open data success stories that will fuel future advocacy efforts.

  7. The Reliability Estimation for the Open Function of Cabin Door Affected by the Imprecise Judgment Corresponding to Distribution Hypothesis

    Science.gov (United States)

    Yu, Z. P.; Yue, Z. F.; Liu, W.

    2018-05-01

    With the development of artificial intelligence, more and more reliability experts have noticed the roles of subjective information in the reliability design of complex system. Therefore, based on the certain numbers of experiment data and expert judgments, we have divided the reliability estimation based on distribution hypothesis into cognition process and reliability calculation. Consequently, for an illustration of this modification, we have taken the information fusion based on intuitional fuzzy belief functions as the diagnosis model of cognition process, and finished the reliability estimation for the open function of cabin door affected by the imprecise judgment corresponding to distribution hypothesis.

  8. Open source drug discovery in practice: a case study.

    Science.gov (United States)

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success factors appear to be clearly

  9. Open Source Drug Discovery in Practice: A Case Study

    Science.gov (United States)

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Background Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. Methodology/Principal Findings A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Conclusions/Significance Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality

  10. A kernel for open source drug discovery in tropical diseases.

    Science.gov (United States)

    Ortí, Leticia; Carbajo, Rodrigo J; Pieper, Ursula; Eswar, Narayanan; Maurer, Stephen M; Rai, Arti K; Taylor, Ginger; Todd, Matthew H; Pineda-Lucena, Antonio; Sali, Andrej; Marti-Renom, Marc A

    2009-01-01

    Conventional patent-based drug development incentives work badly for the developing world, where commercial markets are usually small to non-existent. For this reason, the past decade has seen extensive experimentation with alternative R&D institutions ranging from private-public partnerships to development prizes. Despite extensive discussion, however, one of the most promising avenues-open source drug discovery-has remained elusive. We argue that the stumbling block has been the absence of a critical mass of preexisting work that volunteers can improve through a series of granular contributions. Historically, open source software collaborations have almost never succeeded without such "kernels". HERE, WE USE A COMPUTATIONAL PIPELINE FOR: (i) comparative structure modeling of target proteins, (ii) predicting the localization of ligand binding sites on their surfaces, and (iii) assessing the similarity of the predicted ligands to known drugs. Our kernel currently contains 143 and 297 protein targets from ten pathogen genomes that are predicted to bind a known drug or a molecule similar to a known drug, respectively. The kernel provides a source of potential drug targets and drug candidates around which an online open source community can nucleate. Using NMR spectroscopy, we have experimentally tested our predictions for two of these targets, confirming one and invalidating the other. The TDI kernel, which is being offered under the Creative Commons attribution share-alike license for free and unrestricted use, can be accessed on the World Wide Web at http://www.tropicaldisease.org. We hope that the kernel will facilitate collaborative efforts towards the discovery of new drugs against parasites that cause tropical diseases.

  11. Acute traumatic central cord syndrome--experience using surgical decompression with open-door expansile cervical laminoplasty.

    Science.gov (United States)

    Uribe, Juan; Green, Barth A; Vanni, Steven; Moza, Kapil; Guest, James D; Levi, Allan D

    2005-06-01

    Open-door expansile cervical laminoplasty (ODECL) is an effective surgical technique in the treatment of multilevel cervical spondylotic myelopathy. In the present study, we reviewed the safety and short-term neurological outcome after expansile cervical laminoplasty in the treatment of acute central cord syndrome. We retrospectively reviewed our database over a 3-year period (January 1997-January 2001) and identified 69 surgically treated cervical spinal cord injuries, including 29 cases of acute traumatic central cord syndrome (ATCCS). Fifteen of these patients underwent expansile cervical laminoplasty, whereas 14 did not because of radiographic evidence of sagittal instability. We collected data on the preoperative and the immediate postoperative and 3-month neurological examinations. Neurological function was assessed using the Asia Spinal Injury Association (ASIA) grading system. We also reviewed the occurrence of complications and short-term radiological stability after the index procedure. The median age was 56 years. All patients had hyperextension injuries with underlying cervical spondylosis and stenosis in the absence of overt fracture or instability. The average delay from injury to surgery was 3 days. The preoperative ASIA grade scale was grade C, 8 patients, and grade D, 7 patients. There were no cases of immediate postoperative deterioration or at 3 months follow-up. Neurological outcome: 71.4% (10/14) of patients improved 1 ASIA grade when examined 3 months post injury. Surgical intervention consisting of ODECL can be safely applied in the subset of patients with ATCCS without instability who have significant cervical spondylosis/stenosis. Open-door expansile cervical laminoplasty is a safe, low-morbidity, decompressive procedure, and in our patients did not produce neurological deterioration.

  12. Image analysis of open-door laminoplasty for cervical spondylotic myelopathy: comparing the influence of cord morphology and spine alignment.

    Science.gov (United States)

    Lin, Bon-Jour; Lin, Meng-Chi; Lin, Chin; Lee, Meei-Shyuan; Feng, Shao-Wei; Ju, Da-Tong; Ma, Hsin-I; Liu, Ming-Ying; Hueng, Dueng-Yuan

    2015-10-01

    Previous studies have identified the factors affecting the surgical outcome of cervical spondylotic myelopathy (CSM) following laminoplasty. Nonetheless, the effect of these factors remains controversial. It is unknown about the association between pre-operative cervical spinal cord morphology and post-operative imaging result following laminoplasty. The goal of this study is to analyze the impact of pre-operative cervical spinal cord morphology on post-operative imaging in patients with CSM. Twenty-six patients with CSM undergoing open-door laminoplasty were classified according to pre-operative cervical spine bony alignment and cervical spinal cord morphology, and the results were evaluated in terms of post-operative spinal cord posterior drift, and post-operative expansion of the antero-posterior dura diameter. By the result of study, pre-operative spinal cord morphology was an effective classification in predicting surgical outcome - patients with anterior convexity type, description of cervical spinal cord morphology, had more spinal cord posterior migration than those with neutral or posterior convexity type after open-door laminoplasty. Otherwise, the interesting finding was that cervical spine Cobb's angle had an impact on post-operative spinal cord posterior drift in patients with neutral or posterior convexity type spinal cord morphology - the degree of kyphosis was inversely proportional to the distance of post-operative spinal cord posterior drift, but not in the anterior convexity type. These findings supported that pre-operative cervical spinal cord morphology may be used as screening for patients undergoing laminoplasty. Patients having neutral or posterior convexity type spinal cord morphology accompanied with kyphotic deformity were not suitable candidates for laminoplasty. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. OpenSearch technology for geospatial resources discovery

    Science.gov (United States)

    Papeschi, Fabrizio; Enrico, Boldrini; Mazzetti, Paolo

    2010-05-01

    In 2005, the term Web 2.0 has been coined by Tim O'Reilly to describe a quickly growing set of Web-based applications that share a common philosophy of "mutually maximizing collective intelligence and added value for each participant by formalized and dynamic information sharing". Around this same period, OpenSearch a new Web 2.0 technology, was developed. More properly, OpenSearch is a collection of technologies that allow publishing of search results in a format suitable for syndication and aggregation. It is a way for websites and search engines to publish search results in a standard and accessible format. Due to its strong impact on the way the Web is perceived by users and also due its relevance for businesses, Web 2.0 has attracted the attention of both mass media and the scientific community. This explosive growth in popularity of Web 2.0 technologies like OpenSearch, and practical applications of Service Oriented Architecture (SOA) resulted in an increased interest in similarities, convergence, and a potential synergy of these two concepts. SOA is considered as the philosophy of encapsulating application logic in services with a uniformly defined interface and making these publicly available via discovery mechanisms. Service consumers may then retrieve these services, compose and use them according to their current needs. A great degree of similarity between SOA and Web 2.0 may be leading to a convergence between the two paradigms. They also expose divergent elements, such as the Web 2.0 support to the human interaction in opposition to the typical SOA machine-to-machine interaction. According to these considerations, the Geospatial Information (GI) domain, is also moving first steps towards a new approach of data publishing and discovering, in particular taking advantage of the OpenSearch technology. A specific GI niche is represented by the OGC Catalog Service for Web (CSW) that is part of the OGC Web Services (OWS) specifications suite, which provides a

  14. Solar cell degradation under open circuit condition in out-doors-in desert region

    Directory of Open Access Journals (Sweden)

    M. Boussaid

    Full Text Available The reliability of solar cells is an important parameter in the design of photovoltaic systems and particularly for cost estimation. Solar cell degradation is the result of various operating conditions; temperature is one of most important factors. Installed PV modules in desert regions are subjected to various temperature changes with significant gradient leading to accelerated degradation. In the present work, we demonstrate the influence of open-circuit condition on the degradation of PV modules. The experiment is carried out in the desert region of ADRAR (southern Algeria using two modules IJISEL of single-crystal silicon. A continuous monitoring allows analysis of both performances of modules for duration of 330 days. The module in open-circuit condition reaches higher temperature means than the module in charging condition; therefore, it undergoes a higher degradation. By simulation, we found that the life of a PV module (whose power output is close to 50% in a condition of an open-circuit in the desert region could be reduced to 4 years, and that has a significant impact on economy. Keywords: WEIBULL, Photovoltaic, Degradation, Open-circuit, Single-crystal, Silicon

  15. Language Policy in Puerto Rico's Higher Education: Opening the Door for Translanguaging Practices

    Science.gov (United States)

    Carroll, Kevin S.; Mazak, Catherine M.

    2017-01-01

    This paper investigates the relationship between meso university language policies in Puerto Rico and their micro instantiations in an undergraduate psychology classroom. We describe a typology of language policies used by 38 universities and campuses in Puerto Rico where their openness allows for flexible implementation of everyday micro policy.…

  16. New customizable phased array UT instrument opens door for furthering research and better industrial implementation

    International Nuclear Information System (INIS)

    Dao, Gavin; Ginzel, Robert

    2014-01-01

    Phased array UT as an inspection technique in itself continues to gain wide acceptance. However, there is much room for improvement in terms of implementation of Phased Array (PA) technology for every unique NDT application across several industries (e.g. oil and petroleum, nuclear and power generation, steel manufacturing, etc.). Having full control of the phased array instrument and customizing a software solution is necessary for more seamless and efficient inspections, from setting the PA parameters, collecting data and reporting, to the final analysis. NDT researchers and academics also need a flexible and open platform to be able to control various aspects of the phased array process. A high performance instrument with advanced PA features, faster data rates, a smaller form factor, and capability to adapt to specific applications, will be discussed

  17. An open door for illegal trade: online sale of Strombocactus disciformis (Cactaceae

    Directory of Open Access Journals (Sweden)

    Vania R. Olmos-Lau

    2016-09-01

    Full Text Available Online trade of CITES listed species has become a persistent threat which is difficult to measure and control. The use of online markets is growing day by the day as technology becomes more available and familiar to people of all ages and interests. Species trade can now be propagated remotely hardly without any real human interaction. We develop a quick-easy method to assess the online availability of the genus Strombocactus, a highly collectible cactus, to understand the real magnitude of this new form of threat and the possible menace it could be for these Mexican cacti. We used the Google.com site to do an online search in four languages (Spanish, English, French and German for the offer of adult plants or seeds. We found specimens and seeds available in major online markets like ebay, amazon, cactusplaza.com and mercado libre. Plant price range from €10.00 to €30.00 plus shipping and handling. The plants were also offered in local online stores in countries like the USA, France, Germany, Australia, Czech Republic, the United Kingdom, and others; some sellers claim they have no obstacles for “shipping across countries” and others openly declare the natural localities where seeds were extracted. Only a minority of these online stores openly stated that the cacti were obtained from CITES registered nurseries or that the cacti were grown through propagules or seeds. Our method is easily transferable to estimate the illegal market for any species. There is an active online trade of Strombocactus species and other species listed in CITES without the necessary documentation. Compliance or other regulation mechanisms are needed in order to promote species conservation.

  18. Comparable clinical and radiological outcomes between skipped-level and all-level plating for open-door laminoplasty.

    Science.gov (United States)

    Cheung, Jason Pui Yin; Cheung, Prudence Wing Hang; Cheung, Amy Yim Ling; Lui, Darren; Cheung, Kenneth M C

    2018-06-01

    To compare the clinical and radiological outcomes between skipped-level and all-level plating for cervical laminoplasty. Patients with cervical spondylotic myelopathy (CSM) treated by open-door laminoplasty with minimum 2-year postoperative follow-up were included. All patients had opening from C3-6 or C3-7 and were divided into skipped-level or all-level plating groups. Japanese Orthopaedic Association (JOA) scores and canal measurements were obtained preoperatively, immediate (within 1 week) postoperatively, and at 2, 6 weeks, 3, 6 and 12 months postoperatively. Paired t test was used for comparative analysis. Receiver operating characteristic analysis was used to determine the canal expansion cutoff for spring-back closure. A total of 74 subjects were included with mean age of 66.1 ± 11.3 years at surgery. Of these, 32 underwent skipped-level plating and 42 underwent all-level plating. No significant differences were noted between the two groups at baseline and follow-up. Spring-back closure was observed in up to 50% of the non-plated levels within 3 months postoperatively. The cutoff for developing spring-back closure was 7 mm canal expansion for C3-6. No differences were observed in JOA scores and recovery rates between the two groups. None of the patients with spring-back required reoperation. There were no significant differences between skipped-level and all-level plating in terms of JOA or recovery rate, and canal diameter differences. This has tremendous impact on saving costs in CSM management as up to two plates per patient undergoing a standard C3-6 laminoplasty may be omitted instead of four plates to every level to achieve similar clinical and radiological outcomes. III. These slides can be retrieved under Electronic Supplementary Material.

  19. Abriendo puertas: conociendo a un celiaco Opening the Doors: Getting to know a celiac

    Directory of Open Access Journals (Sweden)

    María del Mar Ferre Rovira

    2010-12-01

    Full Text Available Justificación: La enfermedad celiaca o celiaquía es una intolerancia al gluten, afecta a cualquier grupo étnico o región, afectando a todas la dimensiones de la vida de los que la padecen. El tratamiento se centra, únicamente, en tomar una dieta sin gluten de por vida. Teniendo en cuenta que el trigo es el cereal de consumo mayoritario en países occidentales, adherirse a esta dieta puede ser realmente dificultoso. Objetivos: Conocer cómo afecta el seguimiento de la dieta sin gluten en la vida cotidiana del celiaco para mejorar su calidad de vida. Diseño: Estudio de caso. Metodología: Entrevistas abiertas semiestructuradas al paciente celiaco y a su entorno más cercano (madre y amigos, así como al enfermero y al trabajador social de su Centro de Salud. Resultados-conclusiones: El seguimiento de la dieta sin gluten afecta tanto a la dimensión personal, familiar y social y económica de la persona celiaca.Background: Celiac disease is an intolerance to gluten, that can affect any ethnicgroup in any region, as well as all aspects of the lives of those who suffer from it. The treatment for this pathology focuses solely on a gluten-free diet for life. Bearing in mind that wheat is the most widely consumed cerealin Western countries, maintaining such a diet can be difficult. Objectives: To learn how a life-long, gluten-free diet daily affects those who suffer from celiac disease in order to be able to improve their quality of life. Design: A case study. Methodology: Conducting open, semi-structured interviews with a patient suffering from celiac disease and those closest to him (mother and friends, as well as with the male nurse and the social worker from his Health Centre. Results and conclusions: A gluten-free diet affects the personal, family and social and economic aspects of the life of an individual suffering from celiac disease.

  20. Common characteristics of open source software development and applicability for drug discovery: a systematic review.

    Science.gov (United States)

    Ardal, Christine; Alstadsæter, Annette; Røttingen, John-Arne

    2011-09-28

    Innovation through an open source model has proven to be successful for software development. This success has led many to speculate if open source can be applied to other industries with similar success. We attempt to provide an understanding of open source software development characteristics for researchers, business leaders and government officials who may be interested in utilizing open source innovation in other contexts and with an emphasis on drug discovery. A systematic review was performed by searching relevant, multidisciplinary databases to extract empirical research regarding the common characteristics and barriers of initiating and maintaining an open source software development project. Common characteristics to open source software development pertinent to open source drug discovery were extracted. The characteristics were then grouped into the areas of participant attraction, management of volunteers, control mechanisms, legal framework and physical constraints. Lastly, their applicability to drug discovery was examined. We believe that the open source model is viable for drug discovery, although it is unlikely that it will exactly follow the form used in software development. Hybrids will likely develop that suit the unique characteristics of drug discovery. We suggest potential motivations for organizations to join an open source drug discovery project. We also examine specific differences between software and medicines, specifically how the need for laboratories and physical goods will impact the model as well as the effect of patents.

  1. [Interdisciplinary pain assessment in the hospital setting : Merely a door-opener to multimodal pain therapy?

    Science.gov (United States)

    Sens, E; Mothes-Lasch, M; Lutz, J F

    2017-12-01

    Chronic pain is characterized by a complex interaction of somatic, mental and social factors. Assessing these factors in patients with chronic pain is vital during the diagnostic work-up and when making a structured treatment plan. Interdisciplinary pain assessment (ISA) is the most promising method to deal with these challenges. This article presents our experience in performing pain assessments in the hospital setting and also illustrates the characteristic features of chronic pain patients undergoing such assessments. This study reviews and evaluates patient data from 2704 ISAs performed at the Interdisciplinary Pain Centre of the Zentralklinik Bad Berka, Germany, between 2008 and 2015. The majority of our ISA patients are severely handicapped and show distinct signs of chronic disease. A large proportion of patients is either unable to work or receiving benefits (invalidity pension or retirement pension). In addition, patients reported long disease durations and high emotional distress. Treatment recommendations were based on the patients' individual clinical presentations and examination results. More than half of the patients required multimodal pain management, while adjustments or therapeutic withdrawal of pain medications, in particular of opioids, were indicated in many patients. Our study shows that ISA enables fast, high-quality diagnostic assessments of chronic pain while taking the biopsychosocial model of pain in particular into account. In addition, ISA is not biased with regard to outcome results and recommends the further treatment that appears best for the individual patient. ISA leads not only to inpatient treatment, but also to treatment in other therapeutic settings and, as such, is not merely a door-opener to multimodal pain therapy.

  2. These Doors Are Open!

    Science.gov (United States)

    Achinstein, Betty; Athanases, Steven Z.; Curry, Marnie W.; Ogawa, Rodney T.; de Oliveira, Luciana C.

    2013-01-01

    Lower-income students of color in California are often underserved, as evidenced by low-resourced schools, an achievement gap, and low college-going rates. Educators increasingly call for "community schools" that link schools with community members and agencies to promote educational achievement and to access communities as resources for…

  3. Open Knee: Open Source Modeling & Simulation to Enable Scientific Discovery and Clinical Care in Knee Biomechanics

    Science.gov (United States)

    Erdemir, Ahmet

    2016-01-01

    Virtual representations of the knee joint can provide clinicians, scientists, and engineers the tools to explore mechanical function of the knee and its tissue structures in health and disease. Modeling and simulation approaches such as finite element analysis also provide the possibility to understand the influence of surgical procedures and implants on joint stresses and tissue deformations. A large number of knee joint models are described in the biomechanics literature. However, freely accessible, customizable, and easy-to-use models are scarce. Availability of such models can accelerate clinical translation of simulations, where labor intensive reproduction of model development steps can be avoided. The interested parties can immediately utilize readily available models for scientific discovery and for clinical care. Motivated by this gap, this study aims to describe an open source and freely available finite element representation of the tibiofemoral joint, namely Open Knee, which includes detailed anatomical representation of the joint's major tissue structures, their nonlinear mechanical properties and interactions. Three use cases illustrate customization potential of the model, its predictive capacity, and its scientific and clinical utility: prediction of joint movements during passive flexion, examining the role of meniscectomy on contact mechanics and joint movements, and understanding anterior cruciate ligament mechanics. A summary of scientific and clinically directed studies conducted by other investigators are also provided. The utilization of this open source model by groups other than its developers emphasizes the premise of model sharing as an accelerator of simulation-based medicine. Finally, the imminent need to develop next generation knee models are noted. These are anticipated to incorporate individualized anatomy and tissue properties supported by specimen-specific joint mechanics data for evaluation, all acquired in vitro from varying age

  4. Open innovation in early drug discovery: roadmaps and roadblocks.

    Science.gov (United States)

    Reichman, Melvin; Simpson, Peter B

    2016-05-01

    Open innovation in pharmaceutical R&D evolved from a triple helix of convergent paradigm shifts in academic, industrial and government research sectors. The birth of the biotechnology sector catalyzed shifts in location dynamics that led to the first wave of open innovation in pharmaceutical R&D between big pharma and startup companies. The National Institutes of Health (NIH) Roadmap was a crucial inflection point that set the stage for a new wave of open innovation models between pharmaceutical companies and universities that have the potential to transform the pharmaceutical R&D landscape. We highlight the attributes of leading protected open innovation models that foster the sharing of proprietary small molecule collections by lowering the risk of premature escape of intellectual property, particularly structure-activity data. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Enabling Open Research Data Discovery through a Recommender System

    Science.gov (United States)

    Devaraju, Anusuriya; Jayasinghe, Gaya; Klump, Jens; Hogan, Dominic

    2017-04-01

    Government agencies, universities, research and nonprofit organizations are increasingly publishing their datasets to promote transparency, induce new research and generate economic value through the development of new products or services. The datasets may be downloaded from various data portals (data repositories) which are general or domain-specific. The Registry of Research Data Repository (re3data.org) lists more than 2500 such data repositories from around the globe. Data portals allow keyword search and faceted navigation to facilitate discovery of research datasets. However, the volume and variety of datasets have made finding relevant datasets more difficult. Common dataset search mechanisms may be time consuming, may produce irrelevant results and are primarily suitable for users who are familiar with the general structure and contents of the respective database. Therefore, we need new approaches to support research data discovery. Recommender systems offer new possibilities for users to find datasets that are relevant to their research interests. This study presents a recommender system developed for the CSIRO Data Access Portal (DAP, http://data.csiro.au). The datasets hosted on the portal are diverse, published by researchers from 13 business units in the organisation. The goal of the study is not to replace the current search mechanisms on the data portal, but rather to extend the data discovery through an exploratory search, in this case by building a recommender system. We adopted a hybrid recommendation approach, comprising content-based filtering and item-item collaborative filtering. The content-based filtering computes similarities between datasets based on metadata such as title, keywords, descriptions, fields of research, location, contributors, etc. The collaborative filtering utilizes user search behaviour and download patterns derived from the server logs to determine similar datasets. Similarities above are then combined with different

  6. Window and door opening behavior, carbon dioxide concentration, temperature, and energy use during the heating season in classrooms with different ventilation retrofits—ASHRAE RP1624

    DEFF Research Database (Denmark)

    Heebøll, Anna; Wargocki, Pawel; Toftum, Jørn

    2018-01-01

    of Copenhagen, Denmark, were retrofitted either with a decentralized, balanced supply and exhaust mechanical ventilation unit with heat recovery; automatically operable windows with an exhaust fan; automatically operable windows with alternating counter-flow heat recovery through slots in the outside wall......; or a visual feedback display unit showing the current classroom carbon dioxide concentration, thus advising when the windows should be opened. For comparison, one classroom retained the original approach for achieving ventilation by manual opening of windows. One year after retrofitting the classrooms carbon...... dioxide concentrations, temperatures, energy use, and window and door opening behavior were recorded during a four week period in the heating season in January. The measured carbon dioxide concentrations were significantly lower in the classrooms with the mechanical ventilation system and the system...

  7. Open Access Could Transform Drug Discovery: A Case Study of JQ1.

    Science.gov (United States)

    Arshad, Zeeshaan; Smith, James; Roberts, Mackenna; Lee, Wen Hwa; Davies, Ben; Bure, Kim; Hollander, Georg A; Dopson, Sue; Bountra, Chas; Brindley, David

    2016-01-01

    The cost to develop a new drug from target discovery to market is a staggering $1.8 billion, largely due to the very high attrition rate of drug candidates and the lengthy transition times during development. Open access is an emerging model of open innovation that places no restriction on the use of information and has the potential to accelerate the development of new drugs. To date, no quantitative assessment has yet taken place to determine the effects and viability of open access on the process of drug translation. This need is addressed within this study. The literature and intellectual property landscapes of the drug candidate JQ1, which was made available on an open access basis when discovered, and conventionally developed equivalents that were not are compared using the Web of Science and Thomson Innovation software, respectively. Results demonstrate that openly sharing the JQ1 molecule led to a greater uptake by a wider and more multi-disciplinary research community. A comparative analysis of the patent landscapes for each candidate also found that the broader scientific diaspora of the publically released JQ1 data enhanced innovation, evidenced by a greater number of downstream patents filed in relation to JQ1. The authors' findings counter the notion that open access drug discovery would leak commercial intellectual property. On the contrary, JQ1 serves as a test case to evidence that open access drug discovery can be an economic model that potentially improves efficiency and cost of drug discovery and its subsequent commercialization.

  8. Accelerating discovery with open-source technology at eLife

    OpenAIRE

    Penfold, Naomi

    2017-01-01

    Accelerating discovery with open-source technology. Talks presented May 2017.Files can be found at https://github.com/npscience/eLife-innovation-May2017-presentation.These slides are derived from a deck shared by Jennifer McLennan. All other sources acknowledged throughout the presentation.

  9. Open Access Target Validation Is a More Efficient Way to Accelerate Drug Discovery

    Science.gov (United States)

    Lee, Wen Hwa

    2015-01-01

    There is a scarcity of novel treatments to address many unmet medical needs. Industry and academia are finally coming to terms with the fact that the prevalent models and incentives for innovation in early stage drug discovery are failing to promote progress quickly enough. Here we will examine how an open model of precompetitive public–private research partnership is enabling efficient derisking and acceleration in the early stages of drug discovery, whilst also widening the range of communities participating in the process, such as patient and disease foundations. PMID:26042736

  10. Harvest: an open platform for developing web-based biomedical data discovery and reporting applications.

    Science.gov (United States)

    Pennington, Jeffrey W; Ruth, Byron; Italia, Michael J; Miller, Jeffrey; Wrazien, Stacey; Loutrel, Jennifer G; Crenshaw, E Bryan; White, Peter S

    2014-01-01

    Biomedical researchers share a common challenge of making complex data understandable and accessible as they seek inherent relationships between attributes in disparate data types. Data discovery in this context is limited by a lack of query systems that efficiently show relationships between individual variables, but without the need to navigate underlying data models. We have addressed this need by developing Harvest, an open-source framework of modular components, and using it for the rapid development and deployment of custom data discovery software applications. Harvest incorporates visualizations of highly dimensional data in a web-based interface that promotes rapid exploration and export of any type of biomedical information, without exposing researchers to underlying data models. We evaluated Harvest with two cases: clinical data from pediatric cardiology and demonstration data from the OpenMRS project. Harvest's architecture and public open-source code offer a set of rapid application development tools to build data discovery applications for domain-specific biomedical data repositories. All resources, including the OpenMRS demonstration, can be found at http://harvest.research.chop.edu.

  11. User Driven Development of Software Tools for Open Data Discovery and Exploration

    Science.gov (United States)

    Schlobinski, Sascha; Keppel, Frank; Dihe, Pascal; Boot, Gerben; Falkenroth, Esa

    2016-04-01

    The use of open data in research faces challenges not restricted to inherent properties such as data quality, resolution of open data sets. Often Open data is catalogued insufficiently or fragmented. Software tools that support the effective discovery including the assessment of the data's appropriateness for research have shortcomings such as the lack of essential functionalities like support for data provenance. We believe that one of the reasons is the neglect of real end users requirements in the development process of aforementioned software tools. In the context of the FP7 Switch-On project we have pro-actively engaged the relevant user user community to collaboratively develop a means to publish, find and bind open data relevant for hydrologic research. Implementing key concepts of data discovery and exploration we have used state of the art web technologies to provide an interactive software tool that is easy to use yet powerful enough to satisfy the data discovery and access requirements of the hydrological research community.

  12. Dramatically Bringing down the Cost of Education with OER: How Open Education Resources Unlock the Door to Free Learning

    Science.gov (United States)

    Wiley, David; Green, Cable; Soares, Louis

    2012-01-01

    The nation is in the midst of a revolution in education. For the first time in human history, tools to enable everyone to attain all the education they desire are available. And best of all this education is available at almost no cost. The key to this sea of change in learning is open education resources, or OER. OER are educational materials…

  13. Retrofit curtain for overhead doors

    Energy Technology Data Exchange (ETDEWEB)

    Leckie, R E

    1987-12-29

    A heat insulating curtain has been developed for reducing heat losses through overhead doors of the type commonly found in industrial warehouses. The curtain consists of a reinforced polyester fabric attached to the outside top of the overhead door and moves with the door as it opens and closes. A T-shaped edge track seals the edges of the curtain to the door frame; the edge of the curtain is also T-shaped and runs up and down the track as the curtain is raised and lowered. The curtain fabric is ultraviolet resistant, durable, flexible, and transparent, and transforms the door into a solar collector which provides solar heated air to the building interior. Two curtains have been satisfactorily installed and tested at a warehouse in Calgary, Alberta. A market evaluation study was conducted to determine the possible buyers for such a door curtain. A target market consisting of those wishing to fix old, leaky doors was selected and a marketing strategy developed. The described strategy includes product development, pricing, distribution, promotion, and advertising. 2 figs., 1 tab.

  14. Long-term outcomes and prognostic analysis of modified open-door laminoplasty with lateral mass screw fusion in treatment of cervical spondylotic myelopathy

    Directory of Open Access Journals (Sweden)

    Su N

    2016-08-01

    Full Text Available Nan Su, Qi Fei, Bingqiang Wang, Dong Li, Jinjun Li, Hai Meng, Yong Yang, Ai Guo Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, People’s Republic of China Objectives: The purpose of the present study was to explore and analyze the long-term outcomes and factors that affect the prognosis of expansive open-door laminoplasty with lateral mass screw fusion in treatment of cervical spondylotic myelopathy (CSM. Methods: We retrospectively reviewed 49 patients with multilevel CSM who had undergone expansive open-door laminoplasty with lateral mass screws fixation and fusion in our hospital between February 2008 and February 2012. The average follow-up period was 4.6 years. The clinical data of patients, including age, sex, operation records, pre- and postoperation Japanese Orthopedic Association (JOA scores, cervical spine canal stenosis, and cervical curvature, were collected. Increased signal intensity (ISI on T2-weighted magnetic resonance imaging and ossification of the posterior longitudinal ligament were also observed. Paired t-test was used to analyze the treatment effectiveness and recovery of neuronal function. The prognostic factors were analyzed with multivariable linear regression model. Results: Forty-nine patients with CSM with a mean age of 59.44 years were enrolled in this study. The average of preoperative JOA score was 9.14±2.25, and postoperative JOA score was 15.31±1.73. There was significant difference between the pre- and postoperative JOA scores. The clinical improvement rate was 80.27%. On follow-up, five patients had complaints of neck and shoulder pain, but no evidence of C5 nerve palsy was found. Developmental cervical spine canal stenosis was present in all patients before surgery. Before surgery, ISI was observed in eight patients, while ossification of the posterior longitudinal ligament was found in 12 patients. The average of preoperative cervical

  15. An evaluation of NCRP report 151--radiation shielding design for radiotherapy facilities, and a feasibility study for 6 MV open-door treatments in an existing high-energy radiation therapy bunker

    Science.gov (United States)

    Kildea, John

    This thesis describes a study of shielding design techniques used for radiation therapy facilities that employ megavoltage linear accelerators. Specifically, an evaluation of the shielding design formalism described in NCRP report 151 was undertaken and a feasibility study for open-door 6 MV radiation therapy treatments in existing 6 MV, 18 MV treatment rooms at the Montreal General Hospital (MGH) was conducted. To evaluate the shielding design formalism of NCRP 151, barrier-attenuated equivalent doses were measured for several of the treatment rooms at the MGH and compared with expectations from NCRP 151 calculations. It was found that, while the insight and recommendations of NCRP 151 are very valuable, its dose predictions are not always correct. As such, the NCRP 151 methodology is best used in conjunction with physical measurements. The feasibility study for 6 MV open-door treatments made use of the NCRP 151 formalism, together with physical measurements for realistic 6 MV workloads. The results suggest that, dosimetrically, 6 MV open door treatments are feasible. A conservative estimate for the increased dose at the door arising from such treatments is 0.1 mSv, with a 1/8 occupancy factor, as recommended in NCRP 151, included.

  16. Doors are opening at children’s day-care centre at Champs-Fréchets

    CERN Multimedia

    HR Department

    2008-01-01

    Opened in August 2008, this new centre offers day-care for children between the ages of 4 months and 4 years. Following an agreement with CERN, up to 20 places are reserved for members of the CERN personnel. The commune of Meyrin invites interested parents to come and visit the centre on Saturday 11 October 2008 from 10 a.m. to 4 p.m. Address : 69, rue des Lattes -1217 Meyrin Further information on the agreement with CERN: https://cern.ch/hr-services/Ben/Social/EVE.asp

  17. A prospective randomized trial comparing anterior cervical discectomy and fusion versus plate-only open-door laminoplasty for the treatment of spinal stenosis in degenerative diseases.

    Science.gov (United States)

    Jiang, Yun-Qi; Li, Xi-Lei; Zhou, Xiao-Gang; Bian, Chong; Wang, Han-Ming; Huang, Jian-Ming; Dong, Jian

    2017-04-01

    For three or more involved cervical levels, there is a debate over which approach yields the best outcomes for the treatment of multilevel cervical degenerative disease. Our objective is to compare the radiological and clinical outcomes of two treatments for multilevel cervical degenerative disease: anterior cervical discectomy and fusion (ACDF) versus plate-only open-door laminoplasty (laminoplasty). Patients were randomized on a 1:1 randomization schedule with 17 patients in the ACDF group and 17 patients in the laminoplasty group. Clinical outcomes were assessed by a visual analog scale (VAS), Japanese Orthopedic Association (JOA) scores, operative time, blood loss, rates of complications, drainage volume, discharge days after surgery, and complications. The cervical spine curvature index (CI) and range of motion (ROM) were assessed with radiographs. The mean VAS score, the mean JOA score, and the rate of complications did not differ significantly between groups. The laminoplasty group had greater blood loss, a longer operative time, more drainage volume, and a longer hospital stay than the ACDF group. There were no significant differences in the CI and ROM between the two groups at baseline and at each follow-up time point. ROM in both groups decreased significantly after surgery. Both ACDF and laminoplasty are effective and safe treatments for multilevel cervical degenerative disease. ACDF causes fewer traumas than laminoplasty.

  18. Open innovation for phenotypic drug discovery: The PD2 assay panel.

    Science.gov (United States)

    Lee, Jonathan A; Chu, Shaoyou; Willard, Francis S; Cox, Karen L; Sells Galvin, Rachelle J; Peery, Robert B; Oliver, Sarah E; Oler, Jennifer; Meredith, Tamika D; Heidler, Steven A; Gough, Wendy H; Husain, Saba; Palkowitz, Alan D; Moxham, Christopher M

    2011-07-01

    Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays interrogate multiple molecular targets and signaling pathways in a target "agnostic" fashion, which may reveal novel functions for well-studied proteins and discover new pathways of therapeutic value. Significantly, existing compound libraries may not have sufficient chemical diversity to fully leverage a phenotypic strategy. To address this issue, Eli Lilly and Company launched the Phenotypic Drug Discovery Initiative (PD(2)), a model of open innovation whereby external research groups can submit compounds for testing in a panel of Lilly phenotypic assays. This communication describes the statistical validation, operations, and initial screening results from the first PD(2) assay panel. Analysis of PD(2) submissions indicates that chemical diversity from open source collaborations complements internal sources. Screening results for the first 4691 compounds submitted to PD(2) have confirmed hit rates from 1.6% to 10%, with the majority of active compounds exhibiting acceptable potency and selectivity. Phenotypic lead generation strategies, in conjunction with novel chemical diversity obtained via open-source initiatives such as PD(2), may provide a means to identify compounds that modulate biology by novel mechanisms and expand the innovation potential of drug discovery.

  19. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

    Science.gov (United States)

    Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Jürgen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Belen Cassera, Maria; Chih-Chien Cheng, Ken; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colón-López, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D’Alessandro, Sarah; Le Dang, Na; Delves, Michael; Du, Alan Y.; Duffy, Sandra; Abd El-Salam El-Sayed, Shimaa; Ferdig, Michael T.; Fernández Robledo, José A.; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Gamo, Francisco Javier; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; Hooft van Huijsduijnen, Rob; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Naranuntarat Jensen, Amornrat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Lafuente, Maria Jose; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinás, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Medina Vera, Iset; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Morais Rodrigues da Costa, Francielly; Müller, Joachim; Muriana, Arantza; Nakazawa Hewitt, Stephen; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Pham, Ngoc; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Abdo Rizk, Mohamed; Ruecker, Andrea; St. Onge, Robert; Salgado Ferreira, Rafaela; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Silva Villela, Filipe; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmüller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Voong Vinh, Phat; Vu, Hoan; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoît; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A.

    2016-01-01

    A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal

  20. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

    Directory of Open Access Journals (Sweden)

    Wesley C Van Voorhis

    2016-07-01

    Full Text Available A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34% of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments

  1. Open science resources for the discovery and analysis of Tara Oceans data.

    Science.gov (United States)

    Pesant, Stéphane; Not, Fabrice; Picheral, Marc; Kandels-Lewis, Stefanie; Le Bescot, Noan; Gorsky, Gabriel; Iudicone, Daniele; Karsenti, Eric; Speich, Sabrina; Troublé, Romain; Dimier, Céline; Searson, Sarah

    2015-01-01

    The Tara Oceans expedition (2009-2013) sampled contrasting ecosystems of the world oceans, collecting environmental data and plankton, from viruses to metazoans, for later analysis using modern sequencing and state-of-the-art imaging technologies. It surveyed 210 ecosystems in 20 biogeographic provinces, collecting over 35,000 samples of seawater and plankton. The interpretation of such an extensive collection of samples in their ecological context requires means to explore, assess and access raw and validated data sets. To address this challenge, the Tara Oceans Consortium offers open science resources, including the use of open access archives for nucleotides (ENA) and for environmental, biogeochemical, taxonomic and morphological data (PANGAEA), and the development of on line discovery tools and collaborative annotation tools for sequences and images. Here, we present an overview of Tara Oceans Data, and we provide detailed registries (data sets) of all campaigns (from port-to-port), stations and sampling events.

  2. Leveraging Crowdsourcing and Linked Open Data for Geoscience Data Sharing and Discovery

    Science.gov (United States)

    Narock, T. W.; Rozell, E. A.; Hitzler, P.; Arko, R. A.; Chandler, C. L.; Wilson, B. D.

    2013-12-01

    Data citation standards can form the basis for increased incentives, recognition, and rewards for scientists. Additionally, knowing which data were utilized in a particular publication can enhance discovery and reuse. Yet, a lack of data citation information in existing publications as well as ambiguities across datasets can limit the accuracy of automated linking approaches. We describe a crowdsourcing approach, based on Linked Open Data, in which AGU abstracts are linked to the data used in those presentations. We discuss our efforts to incentivize participants through promotion of their research, the role that the Semantic Web can play in this effort, and how this work differs from existing platforms such as Mendeley and ResearchGate. Further, we discuss the benefits and challenges of Linked Open Data as a technical solution including the role of provenance, trust, and computational reasoning.

  3. Upgrading inflatable door seals

    International Nuclear Information System (INIS)

    Sykes, T.M.; Metcalfe, R.; Welch, L.A.; Josefowich, J.M.

    1997-01-01

    Inflatable door seals are used for airlocks in CANDU stations. They have been a significant source of unreliability and maintenance cost. A program is underway to improve their performance and reliability, backed by environmental qualification testing. Only commercial products and suppliers existed in 1993. For historical reasons, these 'existing products' did not use the most durable material then available. In hindsight, neither had they been adapted nor optimized to combat conditions often experienced in the plants-sagging doors, damaged sealing surfaces, and many thousands of openings and closings per year. Initial attempts to involve the two existing suppliers in efforts to upgrade these seals were unsuccessful. Another suitable supplier had therefore to be found, and a 'new,' COG-owned seal developed; this was completed in 1997. This paper summarizes its testing, along with that of the two existing products. Resistance to aging has been improved significantly. Testing has shown that an accident can be safely withstood after 10 years of service or 40,000 openings-closings, whichever comes first. AECL's Fluid Sealing Technology Unit (FSTU) has invested in the special moulds, test fixtures and other necessary tooling and documentation required to begin commercial manufacture of this new quality product. Accordingly, as with FSTU's other nuclear products such as pump seals, the long-term supply of door seals to CANDU plants is now protected from many external uncertainties-e.g., commercial products being discontinued, materials being changed, companies going out of business. Manufacturing to AECL's detailed specifications is being subcontracted to the new supplier. FSTU is performing the quality surveillance, inspection, testing, and customer service activities concomitant with direct responsibility for supply to the plants. (author)

  4. Gas dynamic laser having shutter doors

    International Nuclear Information System (INIS)

    Olinger, J.B. Jr.; Wahl, R.L.

    1975-01-01

    A gas dynamic laser is shown wherein gases containing constituents necessary to obtain a lasing action are passed through a nozzle array and directed into a lasing cavity and through a diffuser to an exit. An opening is located on each side of said lasing cavity with a shutter box outside of said cavity having a shutter door for opening or closing said opening. A mirror box is located behind each shutter box and contains a mirror. These mirrors are aligned with the openings in the lasing cavity with each door positioned between an opening and a mirror. Another outlet opening is positioned downstream of the first opening which provides an outlet opening for a laser beam. A shutter box is located around this opening and also houses a shutter door for opening and closing said opening. The mirror box which extends behind this shutter box includes opening means for permitting the output beam to pass through an aerodynamic window to atmosphere. Actuating means are provided for rapidly opening and closing said shutter doors. Bearing means including recirculating balls are located on the top and bottom of each shutter door to ride in tracks at an angle to the sealing surface on the laser device. Vacuum means are provided to reduce the pressure in the shutter box and mirror box independently of the pressure in the lasing cavity

  5. Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.

    Science.gov (United States)

    Bourne, Yves; Renault, Ludovic; Marchot, Pascale

    2015-01-16

    The acetylcholinesterase found in the venom of Bungarus fasciatus (BfAChE) is produced as a soluble, non-amphiphilic monomer with a canonical catalytic domain but a distinct C terminus compared with the other vertebrate enzymes. Moreover, the peripheral anionic site of BfAChE, a surface site located at the active site gorge entrance, bears two substitutions altering sensitivity to cationic inhibitors. Antibody Elec410, generated against Electrophorus electricus acetylcholinesterase (EeAChE), inhibits EeAChE and BfAChE by binding to their peripheral sites. However, both complexes retain significant residual catalytic activity, suggesting incomplete gorge occlusion by bound antibody and/or high frequency back door opening. To explore a novel acetylcholinesterase species, ascertain the molecular bases of inhibition by Elec410, and document the determinants and mechanisms for back door opening, we solved a 2.7-Å resolution crystal structure of natural BfAChE in complex with antibody fragment Fab410. Crystalline BfAChE forms the canonical dimer found in all acetylcholinesterase structures. Equally represented open and closed states of a back door channel, associated with alternate positions of a tyrosine phenol ring at the active site base, coexist in each subunit. At the BfAChE molecular surface, Fab410 is seated on the long Ω-loop between two N-glycan chains and partially occludes the gorge entrance, a position that fully reflects the available mutagenesis and biochemical data. Experimentally based flexible molecular docking supports a similar Fab410 binding mode onto the EeAChE antigen. These data document the molecular and dynamic peculiarities of BfAChE with high frequency back door opening, and the mode of action of Elec410 as one of the largest peptidic inhibitors targeting the acetylcholinesterase peripheral site. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Expansive open-door laminoplasty versus laminectomy and instrumented fusion for cases with cervical ossification of the posterior longitudinal ligament and straight lordosis.

    Science.gov (United States)

    Liu, Xiaowei; Chen, Yu; Yang, Haisong; Li, Tiefeng; Xu, Bin; Chen, Deyu

    2017-04-01

    To identify whether expansive open-door laminoplasty (Lam) is more appropriate than laminectomy and instrumented fusion (LIF) for cases with ossification of the posterior longitudinal ligament (OPLL) and straight cervical lordosis. A total of 67 cases were included and divided into Group Lam (n = 32) and Group LIF (n = 35), and the mean follow-up periods were 38 and 42 months, respectively. The cervical lordosis was elevated by C2-7 Cobb angle and cervical sagittal balance by C2-C7 sagittal vertical axis (SVA). Japanese Orthopedic Association (JOA), neurological recovery rate (RR) being calculated by the JOA, visual analog scale (VAS) and neck disability index (NDI) were used to assess clinical outcomes. Differences in general data between two groups were not significant. Total blood loss and operation duration in Group Lam were both significantly less than that in the Group LIF. By the final follow-up, the cervical lordosis significantly decreased in Group Lam and increased in Group LIF, the SVA significantly increased in Group Lam and kept unchanged in Group LIF, and the JOA, VAS, NDI significantly improved in both groups. Although there was no significant difference in RR between the two groups, cases in Group Lam had significantly larger incidence of postoperative kyphosis and kyphotic change rate, and less VAS, NDI and incidence of axial pain than cases in Group LIF. When compared with the LIF, the Lam is recommended for cases with OPLL and straight cervical lordosis when taking comparable neurological recovery, less axial pain and better neck function improvement into consideration.

  7. Opening the Doors of History

    Institute of Scientific and Technical Information of China (English)

    WANG HAIRONG

    2011-01-01

    China is blessed with a long history,and for millenniums the people of China have used history as a mirror to learn from the past.An important part of the country's history,all the archives of the Communist Party of China (CPC) and the Central Government of the People's Republic of China (PRC) are housed in the Central Archives of China,also known as the State Archives Administration.

  8. Opening the Doors of History

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China’s Central Archives aspires to improve public access to information China is blessed with a long history,and for millenniums the people of China have used history as a mirror to learn from the past. An important part of the country’s history, all the archives of the Communist Party of China (CPC)

  9. SESAME: opening doors through science

    CERN Multimedia

    Pauline Gagnon

    2012-01-01

    Two Pakistani scientists arrived at CERN on 2 February at the height of the cold snap. They will spend the coming year working in collaboration with CERN’s magnet experts, learning the technology and contributing to ongoing projects.   Sumera Yamin (left) and Khalid Mansoor Hassan (right) with quadrupole magnets in the I8 testing facility. Sumera Yamin, a physicist, and Khalid Mansoor Hassan, an electrical engineer, both from the National Centre for Physics in Islamabad, came to CERN under an agreement with Pakistan. “They started contributing right away, helping us design and build new magnets for the ALPHA experiment,” says Davide Tommasini, Head of the resistive magnet section. “They fitted right in, just like I had expected. It is amazing to see that all scientists share the same approach.” The two scientists will also contribute to some aspects of the magnet design and the technical specifications for the SESAME project, the Synchrotron-...

  10. Windows and doors

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    A complete manual is presented on windows and doors for the housing contractor. In order to understand the role of windows and doors in a house's energy performance, an introduction explains the house as a system of components that can have effects on each other. Further chapters explain in detail the parts of a window, window types and RSI values; window servicing and repair; window replacement; parts of a door, door types and RSI values; door service and repair, including weatherstripping; door replacement; and how to ensure quality, service, and customer satisfaction. A glossary of terms is included. 61 figs., 3 tabs.

  11. Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

    Science.gov (United States)

    Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

    2014-01-01

    The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

  12. Exploring open innovation with a patient focus in drug discovery: an evolving paradigm of patient engagement.

    Science.gov (United States)

    Allarakhia, Minna

    2015-06-01

    It is suggested in this article that patient engagement should occur further upstream during the drug discovery stage. 'Lead patients', namely those patients who are proactive with respect to their health, possess knowledge of their disease and resulting symptoms. They are also well informed about the conventional as well as non-conventional treatments for disease management; and so can provide a nuanced perspective to drug design. Understanding how patients view the management of their diseases and how they view the use of conventional versus non-conventional interventions is of imperative importance to researchers. Indeed, this can provide insight into how conventional treatments might be designed from the outset to encourage compliance and positive health outcomes. Consequently, a continuum of lead patient engagement is employed that focuses on drug discovery processes ranging from participative, informative to collaborative engagement. This article looks at a variety of open innovation models that are currently employed across this engagement spectrum. It is no longer sufficient for industry stakeholders to consider conventional therapies as the only mechanisms being sought after by patients. Without patient engagement, the industry risks being re-prioritized in terms of its role in the patient journey towards not only recovery of health, but also sustained health and wellness before disease onset.

  13. Role of Open Source Tools and Resources in Virtual Screening for Drug Discovery.

    Science.gov (United States)

    Karthikeyan, Muthukumarasamy; Vyas, Renu

    2015-01-01

    Advancement in chemoinformatics research in parallel with availability of high performance computing platform has made handling of large scale multi-dimensional scientific data for high throughput drug discovery easier. In this study we have explored publicly available molecular databases with the help of open-source based integrated in-house molecular informatics tools for virtual screening. The virtual screening literature for past decade has been extensively investigated and thoroughly analyzed to reveal interesting patterns with respect to the drug, target, scaffold and disease space. The review also focuses on the integrated chemoinformatics tools that are capable of harvesting chemical data from textual literature information and transform them into truly computable chemical structures, identification of unique fragments and scaffolds from a class of compounds, automatic generation of focused virtual libraries, computation of molecular descriptors for structure-activity relationship studies, application of conventional filters used in lead discovery along with in-house developed exhaustive PTC (Pharmacophore, Toxicophores and Chemophores) filters and machine learning tools for the design of potential disease specific inhibitors. A case study on kinase inhibitors is provided as an example.

  14. Openness and Continuous Collaboration as the Foundation for Entrepreneurial Discovery Process in Finnish Regions

    Directory of Open Access Journals (Sweden)

    Mona ROMAN

    2017-12-01

    Full Text Available Entrepreneurial discovery process (EDP is a bottom-up process engaging regional actors from academic, business, government and civil society together to identify new market opportunities and overcome the potential barriers to innovation. While EDP forms the key principle behind the smart specialization policy of European Commission, its operationalization has remained a challenge. We adopted a grounded theory approach to explore the dynamics of EDP through a case study in Finnish regions. Our aim is to identify the key underlying factors of EDP. Based on the semi-structured interviews with 10 Finnish regions during September 2016, we identified openness, engaging, focused networking and continuous collaboration as the key factors underlying EDP. Our findings contribute to the theoretical debate on what constitutes EDP in the context of smart specialization. We also provide examples for policymakers how to implement these factors based on our case study.

  15. Open-access public-private partnerships to enable drug discovery--new approaches.

    Science.gov (United States)

    Müller, Susanne; Weigelt, Johan

    2010-03-01

    The productivity of the pharmaceutical industry, as assessed by the number of NMEs produced per US dollar spent in R&D, has been in steady decline during the past 40 years. This decline in productivity not only poses a significant challenge to the pharmaceutical industry, but also to society because of the importance of developing drugs for the treatment of unmet medical needs. The major challenge in progressing a new drug to the market is the successful completion of clinical trials. However, the failure rate of drugs entering trials has not decreased, despite various technological and scientific breakthroughs in recent decades, and despite intense target validation efforts. This lack of success suggests limitations in the fundamental understanding of target biology and human pharmacology. One contributing factor may be the traditional secrecy of the pharmaceutical sector, a characteristic that does not promote scientific discovery in an optimal manner. Access to broader knowledge relating to target biology and human pharmacology is difficult to obtain because interactions between researchers in industry and academia are typically restricted to closed collaborations in which the knowledge gained is confidential.However, open-access collaborative partnerships are gaining momentum in industry, and are also favored by funding agencies. Such open-access collaborations may be a powerful alternative to closed collaborations; the sharing of early-stage research data is expected to enable scientific discovery by engaging a broader section of the scientific community in the exploration of new findings. Potentially, the sharing of data could contribute to an increased understanding of biological processes and a decrease in the attrition of clinical programs.

  16. Accelerating target discovery using pre-competitive open science-patients need faster innovation more than anyone else.

    Science.gov (United States)

    Low, Eric; Bountra, Chas; Lee, Wen Hwa

    2016-01-01

    We are experiencing a new era enabled by unencumbered access to high quality data through the emergence of open science initiatives in the historically challenging area of early stage drug discovery. At the same time, many patient-centric organisations are taking matters into their own hands by participating in, enabling and funding research. Here we present the rationale behind the innovative partnership between the Structural Genomics Consortium (SGC)-an open, pre-competitive pre-clinical research consortium and the research-focused patient organisation Myeloma UK to create a new, comprehensive platform to accelerate the discovery and development of new treatments for multiple myeloma.

  17. DISCOVERY OF 14 NEW SLOWLY PULSATING B STARS IN THE OPEN CLUSTER NGC 7654

    International Nuclear Information System (INIS)

    Luo, Y. P.; Han, Z. W.; Zhang, X. B.; Deng, L. C.

    2012-01-01

    We carried out time-series BV CCD photometric observations of the open cluster NGC 7654 (Messier 52) to search for variable stars. Eighteen slowly pulsating B (SPB) stars have been detected, among which 14 candidates are newly discovered, three known ones are confirmed, and a previously found δ Scuti star is also identified as an SPB candidate. Twelve SPBs are probable cluster members based on membership analysis. This makes NGC 7654 the richest galactic open cluster in terms of SPB star content. It is also a new discovery that NGC 7654 hosts three γ Dor star candidates. We found that all these stars (18 SPB and 3 γ Dor stars) have periods longer than their corresponding fundamental radial mode. With such a big sample of g-mode pulsators in a single cluster, it is clear that multi-mode pulsation is more common in the upper part of the main sequence than in the lower part. All the stars span a narrow strip on the period-luminosity plane, which also includes the γ Dor stars at the low-luminosity extension. This result implies that there may be a single period-luminosity relation applicable to all g-mode main-sequence pulsators. As a by-product, three EA-type eclipsing binaries and an EW-type eclipsing binary are also discovered.

  18. Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

    Science.gov (United States)

    Duffy, Sandra; Sykes, Melissa L; Jones, Amy J; Shelper, Todd B; Simpson, Moana; Lang, Rebecca; Poulsen, Sally-Ann; Sleebs, Brad E; Avery, Vicky M

    2017-09-01

    Open-access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open-access Pathogen Box collection is comprised of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens. We tested the Pathogen Box against kinetoplastid parasites and malaria life cycle stages in vitro Consequently, chemical starting points for malaria, human African trypanosomiasis, Chagas disease, and leishmaniasis drug discovery efforts have been identified. Inclusive of this in vitro biological evaluation, outcomes from extensive literature reviews and database searches are provided. This information encompasses commercial availability, literature reference citations, other aliases and ChEMBL number with associated biological activity, where available. The release of this new data for the Pathogen Box collection into the public domain will aid the open-source model of drug discovery. Importantly, this will provide novel chemical starting points for drug discovery and target identification in tropical disease research. Copyright © 2017 Duffy et al.

  19. EMPLACEMENT DRIFT ISOLATION DOOR CONTROL SYSTEM

    International Nuclear Information System (INIS)

    N.T. Raczka

    1998-01-01

    The purpose of this analysis is to review and refine key design concepts related to the control system presently under consideration for remotely operating the emplacement drift isolation doors at the potential subsurface nuclear waste repository at Yucca Mountain. This analysis will discuss the key design concepts of the control system that may be utilized for remotely monitoring, opening, and closing the emplacement drift isolation doors. The scope and primary objectives of this analysis are to: (1) Discuss the purpose and function of the isolation doors (Presented in Section 7.1). (2) Review the construction of the isolation door and other physical characteristics of the doors that the control system will interface with (Presented in Section 7.2). (3) Discuss monitoring and controlling the operation of the isolation doors with a digital control system (either a Programmable Logic Controller (PLC) system or a Distributed Control System (DCS)) (Presented in Section 7.3). (4) Discuss how all isolation doors can be monitored and controlled from a subsurface central control center (Presented in Section 7.4). This analysis will focus on the development of input/output (I/O) counts including the types of I/O, redundancy and fault tolerance considerations, and processor requirements for the isolation door control system. Attention will be placed on operability, maintainability, and reliability issues for the system operating in the subsurface environment with exposure to high temperatures and radiation

  20. Design proposal for door thresholds

    Directory of Open Access Journals (Sweden)

    Smolka Radim

    2017-01-01

    Full Text Available Panels for openings in structures have always been an essential and integral part of buildings. Their importance in terms of a building´s functionality was not recognised. However, the general view on this issue has changed from focusing on big planar segments and critical details to sub-elements of these structures. This does not only focus on the forms of connecting joints but also on the supporting systems that keep the panels in the right position and ensure they function properly. One of the most strained segments is the threshold structure, especially the entrance door threshold structure. It is the part where substantial defects in construction occur in terms of waterproofing, as well as in the static, thermal and technical functions thereof. In conventional buildings, this problem is solved by pulling the floor structure under the entrance door structure and subsequently covering it with waterproofing material. This system cannot work effectively over the long term so local defects occur. A proposal is put forward to solve this problem by installing a sub-threshold door coupler made of composite materials. The coupler is designed so that its variability complies with the required parameters for most door structures on the European market.

  1. Bulkhead Door – Critical Evacuation States

    Directory of Open Access Journals (Sweden)

    Flizikowski Józef

    2017-03-01

    Full Text Available The article is a preliminary to a modification concept of the sliding watertight bulkhead door used on ships and vessels. Hydraulic or electro-hydraulic drives used to move these doors require complicated and extended pressure installations with large amounts of hydraulic fluid. Well-known operational drawbacks of these installations include high level of noise and possibility of various leaks in the hydraulic system. Being the first in a series, the present article describes and analyses critical states which can take place during evacuation of people through openings in the watertight bulkhead doors on seagoing ships and vessels.

  2. Nuclear Storage Overpack Door Actuator and Alignment Apparatus

    International Nuclear Information System (INIS)

    Andreyko, Gregory M.

    2005-01-01

    The invention is a door actuator and alignment apparatus for opening and closing the 15,000-pound horizontally sliding door of a storage overpack. The door actuator includes a ball screw mounted horizontally on a rigid frame including a pair of door panel support rails. An electrically powered ball nut moves along the ball screw. The ball nut rotating device is attached to a carriage. The carriage attachment to the sliding door is horizontally pivoting. Additional alignment features include precision cam followers attached to the rails and rail guides attached to the carriage

  3. Critical element development of double seal door for tritium containment

    International Nuclear Information System (INIS)

    Kanamori, Naokazu; Kakudate, Satoshi; Oka, Kiyoshi; Nakahira, Masataka; Taguchi, Kou; Obara, Kenjiro; Tada, Eisuke; Shibanuma, Kiyoshi; Seki, Masahiro

    1994-08-01

    In fusion experimental reactors, the in-vessel components such as blanket are activated due to D-T operation and they have to be assembled and replaced by remote operation through port penetration of plasma vacuum vessel. A double seal door is inevitably required at an interface between vacuum vessel port and maintenance cask in order to avoid the dispersion of tritium and activated dust during in-vessel component handling. The double seal door should have two open/close doors with four seal surfaces so as to keep leak tightness both of the vacuum vessel and the maintenance cask when doors closed, and to provide access space for handling in-vessel components when doors opened. A prototype compact double seal door with an attractive kinematics of parabolic trajectory has been proposed so as to minimize dead space for the door open/close operation, compared with ordinary slide or hinge type door. Based on this design concept, a sub-scaled model of double seal door with trapezoidal cross-section of around 0.2 m 2 has been fabricated. Through the preliminary experiments such as open/close performance, the double seal door mechanism with parabolic trajectory has been successfully demonstrated. As for leak tightness, seal characteristics of a polyimide ring irradiated up to 10 MGy have been measured. (author)

  4. Development of inverter for elevator door control

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.K.; Choi, U.D.; Jung, M.K.; Choi, S.K. [HHI R and D Center (Korea, Republic of); Yun, J.H.; Han, S.B. [HELCO R and D Center (Korea, Republic of)

    1995-07-01

    Most of the elevator door controllers have been controlled by DC Motors as an actuator. Recently, The control system using AC induction motor and general purpose inverter has been applied to control of elevator door. But there are some difficulties in making use of this system, such as adjustment of door speed pattern, door open-close time, and security of passenger safety. In order to solve these problems, a special inverter has been developed with an encoder feedback. From the result of field-test, we proved that a special inverter with encoder feedback device has come to considerable effect. Until now about 1,200 sets of these inverters are operated in Korea and about 100 sets are operated in South-east Asia. (author). 3 refs., 10 figs., 3 tabs.

  5. Discovering Open Source Discovery: Using VuFind to Create MnPALS Plus

    Science.gov (United States)

    Digby, Todd; Elfstrand, Stephen

    2011-01-01

    The goal of having a robust discovery system is a priority of the libraries the authors serve (both work at the Minnesota State Colleges and Universities). Given the current fiscal situation facing public higher education in their state, the current commercial systems were not affordable for most of their libraries. They decided to implement and…

  6. Beoordeling RWA-installatie Atrium Vertigo: Rookverspreiding door het gebouw

    NARCIS (Netherlands)

    Neuhaus, E.

    2004-01-01

    Het atrium van het Vertigo-gebouw is bouwkundig bedoeld als één groot brandcompartiment. De schuifdeuren en ramen naar aanliggende vertrekken staan echter vaak open. Hierdoor kan de rook zich in het geval van een brand in het atrium gemakkelijk door het gebouw verspreiden door een overdruk in het

  7. Array based Discovery of Aptamer Pairs (Open Access Publisher’s Version)

    Science.gov (United States)

    2014-12-11

    Array-based Discovery of Aptamer Pairs Minseon Cho,†,‡ Seung Soo Oh,‡ Jeff Nie,§ Ron Stewart,§ Monte J. Radeke,⊥ Michael Eisenstein ,†,‡ Peter J...ac504076k | Anal. Chem. 2015, 87, 821−828827 (24) Cho, M.; Oh, S. S.; Nie, J.; Stewart, R.; Eisenstein , M.; Chambers, J.; Marth, J. D.; Walker, F

  8. Molecular property diagnostic suite (MPDS): Development of disease-specific open source web portals for drug discovery.

    Science.gov (United States)

    Nagamani, S; Gaur, A S; Tanneeru, K; Muneeswaran, G; Madugula, S S; Consortium, Mpds; Druzhilovskiy, D; Poroikov, V V; Sastry, G N

    2017-11-01

    Molecular property diagnostic suite (MPDS) is a Galaxy-based open source drug discovery and development platform. MPDS web portals are designed for several diseases, such as tuberculosis, diabetes mellitus, and other metabolic disorders, specifically aimed to evaluate and estimate the drug-likeness of a given molecule. MPDS consists of three modules, namely data libraries, data processing, and data analysis tools which are configured and interconnected to assist drug discovery for specific diseases. The data library module encompasses vast information on chemical space, wherein the MPDS compound library comprises 110.31 million unique molecules generated from public domain databases. Every molecule is assigned with a unique ID and card, which provides complete information for the molecule. Some of the modules in the MPDS are specific to the diseases, while others are non-specific. Importantly, a suitably altered protocol can be effectively generated for another disease-specific MPDS web portal by modifying some of the modules. Thus, the MPDS suite of web portals shows great promise to emerge as disease-specific portals of great value, integrating chemoinformatics, bioinformatics, molecular modelling, and structure- and analogue-based drug discovery approaches.

  9. Close-fitting shield doors with sculptured edges

    International Nuclear Information System (INIS)

    Goodman, L.

    1986-01-01

    The US Department of Energy has contracted with Fluor Technology, Inc. for design and engineering of a facility to begin reprocessing fuel from the reactors at Hanford, Washington. Within the facility, a 15-cm (6-in.)-thick, steel shield door is needed to close an opening 4.3 m (14 ft) high x 8.2 m (27 ft) wide. Two cranes and a centrally located monorail hoist must pass through the opening. The door weighs about 41,000 kg (45 ton), and passage of the hoist will be the most frequent cause for opening the door. These two factors essentially mandated a three-piece door, which allows for using commercially available chain hoists to raise and lower the individual door sections. Normally, there is a 187-Pa (0.75-in. water gauge) pressure differential across the door, and minimal air leakage is essential. Stepped, mating edges between sections and along the adjacent concrete structures are typical with such doors, but so are significant gaps (and air leaks) around the edges. Gaps are needed to preclude frictional jamming between edges as a section is lowered. The challenge was to conceive a method to produce near-zero gaps and preclude jamming without involving impractically tight tolerances. The chosen method was to place trapezoidally shaped, steel gaskets on the door-section edges and on the mating concrete surfaces. The concept is described

  10. A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development.

    Science.gov (United States)

    Gao, Junling; Ceglia, Scott S; Jones, Michael D; Simeone, Jennifer; Antwerp, John Van; Zhang, Li-Kang; Ross, Charles W; Helmy, Roy

    2016-04-15

    A new 'compact mass detector' co-developed with an instrument manufacturer (Waters Corporation) as an interface for liquid chromatography (LC), specifically Ultra-high performance LC(®) (UPLC(®) or UHPLC) analysis was evaluated as a potential new Open Access (OA) LC-MS platform in the Drug Discovery and Early Development space. This new compact mass detector based platform was envisioned to provide increased reliability and speed while exhibiting significant cost, noise, and footprint reductions. The new detector was evaluated in batch mode (typically 1-3 samples per run) to monitor reactions and check purity, as well as in High Throughput Screening (HTS) mode to run 24, 48, and 96 well plates. The latter workflows focused on screening catalysis conditions, process optimization, and library work. The objective of this investigation was to assess the performance, reliability, and flexibility of the compact mass detector in the OA setting for a variety of applications. The compact mass detector results were compared to those obtained by current OA LC-MS systems, and the capabilities and benefits of the compact mass detector in the open access setting for chemists in the drug discovery and development space are demonstrated. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

    OpenAIRE

    Sean Ekins; Alexander L Perryman; Carolina Horta Andrade

    2016-01-01

    The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of...

  12. Maintaining the momentum of Open Search in Earth Science Data discovery

    Science.gov (United States)

    Newman, D. J.; Lynnes, C.

    2013-12-01

    Federated Search for Earth Observation data has been a hallmark of EOSDIS (Earth Observing System Data and Information System) for two decades. Originally, the EOSDIS Version 0 system provided both data-collection-level and granule/file-level search in the mid 1990s with EOSDIS-specific socket protocols and message formats. Since that time, the advent of several standards has helped to simplify EOSDIS federated search, beginning with HTTP as the transfer protocol. Most recently, OpenSearch (www.opensearch.org) was employed for the EOS Clearinghouse (ECHO), based on a set of conventions that had been developed within the Earth Science Information Partners (ESIP) Federation. The ECHO OpenSearch API has evolved to encompass the ESIP RFC and the Open Geospatial Consortium (OGC) Open Search standard. Uptake of the ECHO Open Search API has been significant and has made ECHO accessible to client developers that found the previous ECHO SOAP API and current REST API too complex. Client adoption of the OpenSearch API appears to be largely driven by the simplicity of the OpenSearch convention. This simplicity is thus important to retain as the standard and convention evolve. For example, ECHO metrics indicate that the vast majority of ECHO users favor the following search criteria when using the REST API, - Spatial - bounding box, polygon, line and point - Temporal - start and end time - Keywords - free text Fewer than 10% of searches use additional constraints, particularly those requiring a controlled vocabulary, such as instrument, sensor, etc. This suggests that ongoing standardization efforts around OpenSearch usage for Earth Observation data may be more productive if oriented toward improving support for the Spatial, Temporal and Keyword search aspects. Areas still requiring improvement include support of - Concrete requirements for keyword constraints - Phrasal search for keyword constraints - Temporal constraint relations - Terminological symmetry between search URLs

  13. Leveraging Open Standard Interfaces in Providing Efficient Discovery, Retrieval, and Information of NASA-Sponsored Observations and Predictions

    Science.gov (United States)

    Cole, M.; Alameh, N.; Bambacus, M.

    2006-05-01

    The Applied Sciences Program at NASA focuses on extending the results of NASA's Earth-Sun system science research beyond the science and research communities to contribute to national priority applications with societal benefits. By employing a systems engineering approach, supporting interoperable data discovery and access, and developing partnerships with federal agencies and national organizations, the Applied Sciences Program facilitates the transition from research to operations in national applications. In particular, the Applied Sciences Program identifies twelve national applications, listed at http://science.hq.nasa.gov/earth-sun/applications/, which can be best served by the results of NASA aerospace research and development of science and technologies. The ability to use and integrate NASA data and science results into these national applications results in enhanced decision support and significant socio-economic benefits for each of the applications. This paper focuses on leveraging the power of interoperability and specifically open standard interfaces in providing efficient discovery, retrieval, and integration of NASA's science research results. Interoperability (the ability to access multiple, heterogeneous geoprocessing environments, either local or remote by means of open and standard software interfaces) can significantly increase the value of NASA-related data by increasing the opportunities to discover, access and integrate that data in the twelve identified national applications (particularly in non-traditional settings). Furthermore, access to data, observations, and analytical models from diverse sources can facilitate interdisciplinary and exploratory research and analysis. To streamline this process, the NASA GeoSciences Interoperability Office (GIO) is developing the NASA Earth-Sun System Gateway (ESG) to enable access to remote geospatial data, imagery, models, and visualizations through open, standard web protocols. The gateway (online

  14. Using Face Recognition in the Automatic Door Access Control in a Secured Room

    Directory of Open Access Journals (Sweden)

    Gheorghe Gilca

    2017-06-01

    Full Text Available The aim of this paper is to help users improve the door security of sensitive locations by using face detection and recognition. This paper is comprised mainly of three subsystems: face detection, face recognition and automatic door access control. The door will open automatically for the known person due to the command of the microcontroller.

  15. Diplopie door monovisie

    NARCIS (Netherlands)

    Jorien Schouten; Louise Helmer

    2017-01-01

    Doelstelling: In kaart brengen van de risicofactoren voor het ontwikkelen van binoculaire diplopie na conventionele monovisie door middel van contactlenzen of refractiechirurgie bij presbyopen. Methode: Voor deze literatuurstudie is in maart 2017 gezocht in databanken Pubmed, ScienceDirect en Google

  16. Motor actuated vacuum door. [for photography from sounding rockets

    Science.gov (United States)

    Hanagud, A. V.

    1986-01-01

    Doors that allow scientific instruments to record and retrieve the observed data are often required to be designed and installed as a part of sounding rocket hardware. The motor-actuated vacuum door was designed to maintain a medium vacuum of the order of 0.0001 torr or better while closed, and to provide an opening 15 inches long x 8.5 inches wide while open for cameras to image Halley's comet. When the electric motor receives the instruction to open the door through the payload battery, timer, and relay circuit, the first operation is to unlock the door. After unlatching, the torque transmitted by the motor to the main shaft through the links opens the door. A microswitch actuator, which rides on the linear motion conversion mechanism, is adjusted to trip the limit switch at the end of the travel. The process is repeated in the reverse order to close the door. 'O' rings are designed to maintain the seal. Door mechanisms similar to the one described have flown on Aerobee 17.018 and Black Brant 27.047 payloads.

  17. Improving knowledge discovery from synthetic aperture radar images using the linked open data cloud and Sextant

    NARCIS (Netherlands)

    C. Nikolaou (Charalampos); K. Kyzirakos (Konstantinos); K. Bereta (Konstantina); K. Dogani (Kallirroi); S. Giannakopoulou (Stella); P. Smeros (Panayiotis); G. Garbis (George); M. Koubarakis (Manolis); D.E. Molina (Daniela); O.C. Dumitru (Octavian); G. Schwarz (Gottfried); M. Datcu (Mihai); P. Soille; M. Iapaolo; P.G. Marchetti; M. Datcu (Mihai); L. Colaiacomo

    2014-01-01

    htmlabstractIn the last few years, thanks to projects like TELEIOS, the linked open data cloud has been rapidly populated with geospatial data some of it describing Earth Observation products (e.g., CORINE Land Cover, Urban Atlas). The abundance of this data can prove very useful to the new missions

  18. Self-Discovery through Character Connections: Opening up to Gayness in "Angels in America"

    Science.gov (United States)

    Blazar, David

    2009-01-01

    In this article, the author describes how he uses performance pedagogy to open students' minds to sexuality and gender issues. The author uses Tony Kushner's "Angels in America: A Gay Fantasia on National Themes"--an epic play about the AIDS epidemic and its impact on the gay community in the 1980s. Through the possibilities of drama available in…

  19. Door Locking Options in Schools

    Science.gov (United States)

    National Clearinghouse for Educational Facilities, 2009

    2009-01-01

    Doors serve a variety of needs and purposes in schools: (1) Exterior doors provide building security and protection from the elements; and (2) Interior doors control the movement of people among school spaces, help control noise and air flow, and act as flame and smoke barriers during a fire. In a lockdown, they serve as safety barriers. From a…

  20. Hazards in smart grids. Smart meters can open the door to hackers; Gefahren im intelligenten Stromnetz. Smart Meter als Einfallstor fuer Hacker-Angriffe

    Energy Technology Data Exchange (ETDEWEB)

    Gerretz, Dirk [Covisint Emea Compuware GmbH, Neu-Isenburg (Germany)

    2011-10-31

    Smart grid, smart meter, smart home: Increasingly, intelligent technologies are introduced in the energy sector. The merging of power grids and data grids is costly and requires high investments in areas that are far from the key business and key competence of public utilities. Reliable protection of smart meters is a particular challenge as unauthorized access or manipulation may result in great financial and reputational damage. Prior to introducting smart meters, utilities should decide if they want to introduce the necessary safety technologies themselves, including hardware, software, and know-how, or if they want to rely on solutions provided by experienced market partners. They offer open, expandable and scalable platforms for comprehensive identity management and safe data exchange that have been tested in practice in several branches of industry.

  1. Relativistic jets in narrow-line Seyfert 1 galaxies. New discoveries and open questions

    Directory of Open Access Journals (Sweden)

    D’Ammando F.

    2013-12-01

    Full Text Available Before the launch of the Fermi satellite only two classes of AGNs were known to produce relativistic jets and thus emit up to the γ-ray energy range: blazars and radio galaxies, both hosted in giant elliptical galaxies. The first four years of observations by the Large Area Telescope on board Fermi confirmed that these two are the most numerous classes of identified sources in the extragalactic γ-ray sky, but the discovery of γ-ray emission from 5 radio-loud narrow-line Seyfert 1 galaxies revealed the presence of a possible emerging third class of AGNs with relativistic jets. Considering that narrow-line Seyfert 1 galaxies seem to be typically hosted in spiral galaxy, this finding poses intriguing questions about the nature of these objects, the onset of production of relativistic jets, and the cosmological evolution of radio-loud AGN. Here, we discuss the radio-to-γ-rays properties of the γ-ray emitting narrow-line Seyfert 1 galaxies, also in comparison with the blazar scenario.

  2. China's upstream oil and gas industry opens in steps to outsiders, awaits big discovery

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Since 1979, when the government began opening upstream projects to foreign capital, international companies have invested more than $4.2 billion in Chinese exploration and production, most of it offshore. But the payoff, both to China and to its new international investors, has been limited. The trend, nevertheless, is toward more and better opportunities for companies from outside China. The government wants the country to return to petroleum self-sufficiency. It recognizes that economic growth of 8--10%/year will keep demand rising steadily and make self-sufficiency increasingly difficult to reachieve and maintain. What's most important, it recognized long ago that the capital and technology essential to the job can come only from abroad. The paper discusses the shifting emphasis of the government's dealings with outsiders; the second round of bidding for onshore tracts; operations of the China National Petroleum Corp. which handles onshore operations; offshore operations; and China's progress since 1979

  3. HydroDesktop: An Open Source GIS-Based Platform for Hydrologic Data Discovery, Visualization, and Analysis

    Science.gov (United States)

    Ames, D. P.; Kadlec, J.; Cao, Y.; Grover, D.; Horsburgh, J. S.; Whiteaker, T.; Goodall, J. L.; Valentine, D. W.

    2010-12-01

    A growing number of hydrologic information servers are being deployed by government agencies, university networks, and individual researchers using the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) Hydrologic Information System (HIS). The CUAHSI HIS Project has developed a standard software stack, called HydroServer, for publishing hydrologic observations data. It includes the Observations Data Model (ODM) database and Water Data Service web services, which together enable publication of data on the Internet in a standard format called Water Markup Language (WaterML). Metadata describing available datasets hosted on these servers is compiled within a central metadata catalog called HIS Central at the San Diego Supercomputer Center and is searchable through a set of predefined web services based queries. Together, these servers and central catalog service comprise a federated HIS of a scale and comprehensiveness never previously available. This presentation will briefly review/introduce the CUAHSI HIS system with special focus on a new HIS software tool called "HydroDesktop" and the open source software development web portal, www.HydroDesktop.org, which supports community development and maintenance of the software. HydroDesktop is a client-side, desktop software application that acts as a search and discovery tool for exploring the distributed network of HydroServers, downloading specific data series, visualizing and summarizing data series and exporting these to formats needed for analysis by external software. HydroDesktop is based on the open source DotSpatial GIS developer toolkit which provides it with map-based data interaction and visualization, and a plug-in interface that can be used by third party developers and researchers to easily extend the software using Microsoft .NET programming languages. HydroDesktop plug-ins that are presently available or currently under development within the project and by third party

  4. Development, Control, and Evaluation of an Actuated Car Door.

    Science.gov (United States)

    Strolz, M; Mortl, A; Graf, M; Buss, M

    2009-01-01

    Actuated car doors are a promising way to increase the convenience of access to cars. We propose an advanced actuation and control concept which can easily be integrated into conventional car doors. By utilizing a linear, nonbackdrivable actuator and various sensors, both automatic and manual door operations are enabled. A discrete state controller ensures a safe operation of the door, including automatic opening and closing. The realization of a supportive, high-quality haptic interaction with the car door for the manual operation is the principal part of our work. Due to the impracticality of a direct measurement of the user interaction force at a car door, we chose impedance control to render the desired dynamics. The impedance was designed to provide a convenient, intuitive, and safe manual handling of the door. We implemented and tested four different impedance control schemes, of which impedance control with actuator force feedback performed best. Two experimental evaluations with 16 and 27 participants revealed a predominant approval of the actuated car door.

  5. Door valve for fuel handling path

    International Nuclear Information System (INIS)

    Makishima, Katsuhiko.

    1969-01-01

    A door valve is provided which seals cover gas from a liquid metal cooled reactor without leakage therefrom. A threaded shaft is screwed into a heavy box press which is packed with lead. The shaft is adapted to be rotated by an electric motor or a manually operated wheel which is disposed outside of the door valve. From the box press a valve plate is suspended by four linkage bars, one for each corner. Each linkage bar is provided with two wheels which are respectively mounted at the connections with the box press and the valve plate. The wheels are carried on the horizontal grooves formed in a door valve casing. In operation the shaft rotates and travels to permit the box press and the valve plate to move into the door valve casing while the valve plate does not contact the casing. When the box press reaches the home position, the wheels drop into the recesses which are disposed at the ends of the grooves, the valve plate is carried on the valve opening, and the box press presses the valve plate to increase the tightness. The valve plate does not suffer wear as it does not over other parts. (Yamaguchi, T.)

  6. Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma.

    Directory of Open Access Journals (Sweden)

    Megan Ulmer Carnes

    Full Text Available Glaucoma is a leading cause of blindness worldwide. Primary open-angle glaucoma (POAG is the most common subtype and is a complex trait with multigenic inheritance. Genome-wide association studies have previously identified a significant association between POAG and the SIX6 locus (rs10483727, odds ratio (OR = 1.32, p = 3.87×10(-11. SIX6 plays a role in ocular development and has been associated with the morphology of the optic nerve. We sequenced the SIX6 coding and regulatory regions in 262 POAG cases and 256 controls and identified six nonsynonymous coding variants, including five rare and one common variant, Asn141His (rs33912345, which was associated significantly with POAG (OR = 1.27, p = 4.2×10(-10 in the NEIGHBOR/GLAUGEN datasets. These variants were tested in an in vivo Danio rerio (zebrafish complementation assay to evaluate ocular metrics such as eye size and optic nerve structure. Five variants, found primarily in POAG cases, were hypomorphic or null, while the sixth variant, found only in controls, was benign. One variant in the SIX6 enhancer increased expression of SIX6 and disrupted its regulation. Finally, to our knowledge for the first time, we have identified a clinical feature in POAG patients that appears to be dependent upon SIX6 genotype: patients who are homozygous for the SIX6 risk allele (His141 have a statistically thinner retinal nerve fiber layer than patients homozygous for the SIX6 non-risk allele (Asn141. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells, thereby increasing the risk of glaucoma-associated vision loss.

  7. Landing Gear Door Liners for Airframe Noise Reduction

    Science.gov (United States)

    Jones, Michael G. (Inventor); Howerton, Brian M. (Inventor); Van De Ven, Thomas (Inventor)

    2014-01-01

    A landing gear door for retractable landing gear of aircraft includes an acoustic liner. The acoustic liner includes one or more internal cavities or chambers having one or more openings that inhibit the generation of sound at the surface and/or absorb sound generated during operation of the aircraft. The landing gear door may include a plurality of internal chambers having different geometries to thereby absorb broadband noise.

  8. The Globe reopens its doors

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    After a year of work, the newly renovated Globe of Science and Innovation will open its doors again at 10 a.m. on Tuesday, 19 April. The “Universe of Particles” exhibition has been updated and will be open to the public, free of charge, from 10 a.m. to 5 p.m., Monday to Saturday (except during official CERN closures). The Globe’s programme of lectures and events for the general public will restart at the end of April. What’s on at the Globe in April and May: - 28 April at 6.30 p.m.: Theatre – “Curie_Meitner_Lamarr_indivisible”, a play that pays tribute to the lives of three exceptional women in the field of science and technology (in English). Reservations: http://indico.cern.ch/e/cmli - 10 May at 8.30 p.m.: Lecture – “Le modèle du CERN et les grands défis mondiaux” (“The CERN model and the key global challenges”) by Michel Spiro (in French with simultaneous ...

  9. Particulate matter (PM 2.5 levels in ETS emissions of a Marlboro Red cigarette in comparison to the 3R4F reference cigarette under open- and closed-door condition

    Directory of Open Access Journals (Sweden)

    Mueller Daniel

    2012-06-01

    Full Text Available Abstract Introduction Potential health damage by environmental emission of tobacco smoke (environmental tobacco smoke, ETS has been demonstrated convincingly in numerous studies. People, especially children, are still exposed to ETS in the small space of private cars. Although major amounts of toxic compounds from ETS are likely transported into the distal lung via particulate matter (PM, few studies have quantified the amount of PM in ETS. Study aim The aim of this study was to determine the ETS-dependent concentration of PM from both a 3R4F reference cigarette (RC as well as a Marlboro Red brand cigarette (MRC in a small enclosed space under different conditions of ventilation to model car exposure. Method In order to create ETS reproducibly, an emitter (ETSE was constructed and mounted on to an outdoor telephone booth with an inner volume of 1.75 m3. Cigarettes were smoked under open- and closed-door condition to imitate different ventilation scenarios. PM2.5 concentration was quantified by a laser aerosol spectrometer (Grimm; Model 1.109, and data were adjusted for baseline values. Simultaneously indoor and outdoor climate parameters were recorded. The time of smoking was divided into the ETS generation phase (subset “emission” and a declining phase of PM concentration (subset “elimination”; measurement was terminated after 10 min. For all three time periods the average concentration of PM2.5 (Cmean-PM2.5 and the area under the PM2.5 concentration curve (AUC-PM2.5 was calculated. The maximum concentration (Cmax-PM2.5 was taken from the total interval. Results For both cigarette types open-door ventilation reduced the AUC-PM2.5 (RC: from 59 400 ± 14 600 to 5 550 ± 3 900 μg*sec/m3; MRC: from 86 500 ± 32 000 to 7 300 ± 2 400 μg*sec/m3; p mean-PM2.5 (RC: from 600 ± 150 to 56 ± 40 μg/m3, MRC from 870 ± 320 to 75 ± 25 μg/m3; p max-PM2.5 was reduced by about 80% (RC: from 1 050 ± 230 to

  10. Serious Learning with Science Comics: "Antarctic Log" as a Tool for Understanding Climate Research in AntarcticaScience comics open doors, providing multiple entry points for diverse learners. Karen Romano Young, award-winning author, presents "Antarctic Log", a comic about her spring 2018 Palmer Station tour, a tool for teaching and inspiration.

    Science.gov (United States)

    Young, K. R.

    2017-12-01

    Graphic nonfiction: what is it? Some call these books and articles science comics, but they're no joke: created through research and direct experience by artists invested in creating multiple entry points for new learners, comics can open doors for discovery as introduction, enrichment, or as a vital center point to teaching. Find out what educational pedagogists, scientists, and - yes! - students themselves think about reading, viewing, learning from, and creating science comics in the classroom. Karen Romano Young is the award-winning author of traditional and graphic fiction and nonfiction for children, including Doodlebug, the forthcoming Diving for Deep-Sea Dragons, and the Odyssey/Muse magazine comics feature Humanimal Doodles. In spring 2018 (Antarctic autumn) Young will work as part of a Bigelow Laboratory team studying the production of DMSP by phytoplankton, and the resulting cloud formation. This is invisible stuff, difficult for lay audiences to envision and comprehend. But the audience is already forming around "Antarctic Log," a science comic that tells the story of the science and the experience of doing climate research at Palmer Station as winter draws near. Science comics aren't just for enrichment. They're an invitation, providing multiple entry points for diverse learners. I have received unanticipated support from education groups (including NSTA and IRA), parenting groups, and special educators because these highly visual presentations of middle grade and middle school level material makes the stories and concepts accessible to atypical fiction- and science-reading audiences. As a result, I've learned a great deal about the underlying differences between my material and traditional, text-oriented materials in which visuals may be highly coordinated but are still ancillary. An article that might seem forbidding as text appears open to interpretation in my format, so that readers can pick where to begin reading and how to proceed through the

  11. Opening the Door to Coaching Conversations

    Science.gov (United States)

    Cheliotes, Linda Gross; Reilly, Marceta Fleming

    2012-01-01

    A leader doesn't have to solve every problem personally to be effective. In fact, helping others learn to resolve issues and implement their own solutions is the key to sustainable leadership and an empowered staff. This companion and follow-up book to "Coaching Conversations" brings the coaching style of leadership to life with stories from the…

  12. Opening the door to nuclear development

    International Nuclear Information System (INIS)

    Sethna, H.N.

    1985-01-01

    The author discusses how the Atoms for Peace speech heralded the birth of an era of cooperation between the sovereign nations of the world in the peaceful uses of atomic energy for the benefit of all mankind. He explains how India imported the technology it needed to implement its own nuclear power program. India not only assimilated this imported technology completely, but also adapted it to its own conditions and requirements. Action was also taken to diversify, improve and scale up the technology so as to be independent of further imports. The author says that the initial cooperation agreement made by Eisenhower has been the bedrock on which India's nuclear program has been built

  13. "Abriendo Puertas" (Opening Doors) through Writing

    Science.gov (United States)

    Sarmiento, Lilia E.; Vasquez, Sergio A.

    2010-01-01

    A Latina college professor describes the family history-writing project she uses in her reading/language arts teacher preparation course. The project provides opportunities for Spanish bilingual teacher candidates to gain greater understanding of their cultural selves and to consider ways to successfully deploy that new insight as teachers in…

  14. Educational Authority in the ''Open Door'' Marketplace

    Science.gov (United States)

    Deterding, Nicole M.; Pedulla, David S.

    2016-01-01

    In recent years, private for-profit education has been the fastest growing segment of the U.S. postsecondary system. Traditional hiring models suggest that employers clearly and efficiently evaluate college credentials, but this changing institutional landscape raises an important question: How do employers assess credentials from emerging…

  15. Opening doors to knowledge in Bhutan.

    Science.gov (United States)

    1994-01-01

    School girls, teachers, and health school students were surveyed, using 3 different questionnaires, in January 1993. Catherine Payne, former research associate of the Family Planning Council of Southeastern Pennsylvania, visited Bhutan from August 18 through September 4, 1993, to assist with the interpretation of results and to interview teachers in schools where the new curriculum would be introduced and officials who were writing it. Results were released in October 1993. 160 young women (10-20 years of age) from 5 schools were surveyed and another 60 were interviewed by Payne. 25% of the surveyed girls understood the connection between menstruation and reproduction. Of those who had heard of menstruation, 60% had heard about it from their friends; 30%, from siblings; 27%, from mothers; and 10%, from schools. Teachers in the survey were supportive of the study and recognized the importance of reproductive health education. Also, officials of the education and health ministries, epidemiologists, experts in information, education, and communication (IEC), and district health officers attended a 2-day workshop directed at local data collection and analysis of this type. Although teenage pregnancy and sexually transmitted diseases (STDs) are increasing in Bhutan, family planning services are not reaching youth, particularly those who do not attend school or do not have children. Hospitals provide contraceptives mainly to those over 21, and outreach clinics are not catering to the family planning needs of minors. One of the recommendations of this survey/workshop was to provide correct information on reproductive health to youth.

  16. Minority Outlook: Opening the Door in Biomedicine.

    Science.gov (United States)

    Freiherr, Gregory

    1979-01-01

    The national Minority Biomedical Support (MBS) Program, established in 1972 with National Institutes of Health funds, is described with emphasis on its role in increasing minority representation in biomedical research. (LBH)

  17. Knocking on a wide open door

    DEFF Research Database (Denmark)

    Kragelund, Peter

    2009-01-01

    The current strong foothold of Chinese enterprises on the African continent concerns many western observers. They fear that the West will lose leverage in Africa and simultaneously postpone development. Paradoxically, the advance of Chinese enterprises in Africa is not only the result of delibera...

  18. Opening the Door on Triangular Numbers

    Science.gov (United States)

    McMartin, Kimberley; McMaster, Heather

    2016-01-01

    As an alternative to looking solely at linear functions, a three-lesson learning progression developed for Year 6 students that incorporates triangular numbers to develop children's algebraic thinking is described and evaluated.

  19. Opening Doors to Teaching: Understanding the Profession

    Science.gov (United States)

    Langner, Jonas; Zhok, Andrea

    2016-01-01

    Teaching, together with translating, is probably one of the employment options most closely associated with a Modern Foreign Languages degree, or at least one where the language skills acquired are an intrinsic part of the profession in question. Yet, British undergraduate language degree programmes do not systematically offer students…

  20. Electricity supply opportunities -- The Mexican door opens

    International Nuclear Information System (INIS)

    Holland, H.W.

    1993-01-01

    Anyone who assumes that the Mexican market for electrical capacity is just a matter of selling equipment and services is in for a shock. The astute neighbor to the south is exploring privatization in the power sector with a style and flair that is uniquely Mexican. While free market-market forces have, to some extent, already transformed the manner in which new generating capacity is added in the US, a Mexico equivalent will not develop over night. Mexico is no place for the faint of heart. You have to play hard in order to win against competition almost equivalent to that of the US market and have the staying power to be around long enough to reap the rewards. This work presents the author's views concerning the manner in which competition has been introduced within the electricity supply market of the neighbor to the south

  1. Massive open star clusters using the VVV survey. II. Discovery of six clusters with Wolf-Rayet stars

    Science.gov (United States)

    Chené, A.-N.; Borissova, J.; Bonatto, C.; Majaess, D. J.; Baume, G.; Clarke, J. R. A.; Kurtev, R.; Schnurr, O.; Bouret, J.-C.; Catelan, M.; Emerson, J. P.; Feinstein, C.; Geisler, D.; de Grijs, R.; Hervé, A.; Ivanov, V. D.; Kumar, M. S. N.; Lucas, P.; Mahy, L.; Martins, F.; Mauro, F.; Minniti, D.; Moni Bidin, C.

    2013-01-01

    Context. The ESO Public Survey "VISTA Variables in the Vía Láctea" (VVV) provides deep multi-epoch infrared observations for an unprecedented 562 sq. degrees of the Galactic bulge, and adjacent regions of the disk. Nearly 150 new open clusters and cluster candidates have been discovered in this survey. Aims: This is the second in a series of papers about young, massive open clusters observed using the VVV survey. We present the first study of six recently discovered clusters. These clusters contain at least one newly discovered Wolf-Rayet (WR) star. Methods: Following the methodology presented in the first paper of the series, wide-field, deep JHKs VVV observations, combined with new infrared spectroscopy, are employed to constrain fundamental parameters for a subset of clusters. Results: We find that the six studied stellar groups are real young (2-7 Myr) and massive (between 0.8 and 2.2 × 103 M⊙) clusters. They are highly obscured (AV ~ 5-24 mag) and compact (1-2 pc). In addition to WR stars, two of the six clusters also contain at least one red supergiant star, and one of these two clusters also contains a blue supergiant. We claim the discovery of 8 new WR stars, and 3 stars showing WR-like emission lines which could be classified WR or OIf. Preliminary analysis provides initial masses of ~30-50 M⊙ for the WR stars. Finally, we discuss the spiral structure of the Galaxy using the six new clusters as tracers, together with the previously studied VVV clusters. Based on observations with ISAAC, VLT, ESO (programme 087.D-0341A), New Technology Telescope at ESO's La Silla Observatory (programme 087.D-0490A) and with the Clay telescope at the Las Campanas Observatory (programme CN2011A-086). Also based on data from the VVV survey (programme 172.B-2002).

  2. Computational science and re-discovery: open-source implementation of ellipsoidal harmonics for problems in potential theory

    International Nuclear Information System (INIS)

    Bardhan, Jaydeep P; Knepley, Matthew G

    2012-01-01

    We present two open-source (BSD) implementations of ellipsoidal harmonic expansions for solving problems of potential theory using separation of variables. Ellipsoidal harmonics are used surprisingly infrequently, considering their substantial value for problems ranging in scale from molecules to the entire solar system. In this paper, we suggest two possible reasons for the paucity relative to spherical harmonics. The first is essentially historical—ellipsoidal harmonics developed during the late 19th century and early 20th, when it was found that only the lowest-order harmonics are expressible in closed form. Each higher-order term requires the solution of an eigenvalue problem, and tedious manual computation seems to have discouraged applications and theoretical studies. The second explanation is practical: even with modern computers and accurate eigenvalue algorithms, expansions in ellipsoidal harmonics are significantly more challenging to compute than those in Cartesian or spherical coordinates. The present implementations reduce the 'barrier to entry' by providing an easy and free way for the community to begin using ellipsoidal harmonics in actual research. We demonstrate our implementation using the specific and physiologically crucial problem of how charged proteins interact with their environment, and ask: what other analytical tools await re-discovery in an era of inexpensive computation?

  3. Door Hardware and Installations; Carpentry: 901894.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    The curriculum guide outlines a course designed to provide instruction in the selection, preparation, and installation of hardware for door assemblies. The course is divided into five blocks of instruction (introduction to doors and hardware, door hardware, exterior doors and jambs, interior doors and jambs, and a quinmester post-test) totaling…

  4. Opening Data in the Long Tail for Community Discovery, Curation and Action Using Active and Social Curation

    Science.gov (United States)

    Hedstrom, M. L.; Kumar, P.; Myers, J.; Plale, B. A.

    2012-12-01

    In data science, the most common sequence of steps for data curation are to 1) curate data, 2) enable data discovery, and 3) provide for data reuse. The Sustainable Environments - Actionable Data (SEAD) project, funded through NSF's DataNet program, is creating an environment for sustainability scientists to discover data first, reuse data next, and curate data though an on-going process that we call Active and Social Curation. For active curation we are developing tools and services that support data discovery, data management, and data enhancement for the community while the data is still being used actively for research. We are creating an Active Content Repository, using drop box, semantic web technologies, and a Flickr-like interface for researchers to "drop" data into a repository where it will be replicated and minimally discoverable. For social curation, we are deploying a social networking tool, VIVO, which will allow researchers to discover data-publications-people (e.g. expertise) through a route that can start at any of those entry points. The other dimension of social curation is developing mechanisms to open data for community input, for example, using ranking and commenting mechanisms for data sets and a community-sourcing capability to add tags, clean up and validate data sets. SEAD's strategies and services are aimed at the sustainability science community, which faces numerous challenges including discovery of useful data, cleaning noisy observational data, synthesizing data of different types, defining appropriate models, managing and preserving their research data, and conveying holistic results to colleagues, students, decision makers, and the public. Sustainability researchers make significant use of centrally managed data from satellites and national sensor networks, national scientific and statistical agencies, and data archives. At the same time, locally collected data and custom derived data products that combine observations and

  5. Modeling and Simulation of Two Wheelchair Accessories for Pushing Doors.

    Science.gov (United States)

    Abdullah, Soran Jalal; Shaikh Mohammed, Javeed

    2017-03-27

    Independent mobility is vital to individuals of all ages, and wheelchairs have proven to be great personal mobility devices. The tasks of opening and navigating through a door are trivial for healthy people, while the same tasks could be difficult for some wheelchair users. A wide range of intelligent wheelchair controllers and systems, robotic arms, or manipulator attachments integrated with wheelchairs have been developed for various applications, including manipulating door knobs. Unfortunately, the intelligent wheelchairs and robotic attachments are not widely available as commercial products. Therefore, the current manuscript presents the modeling and simulation of a novel but simple technology in the form of a passive wheelchair accessory (straight, arm-like with a single wheel, and arc-shaped with multiple wheels) for pushing doors open from a wheelchair. From the simulations using different wheel shapes and sizes, it was found that the arc-shaped accessory could push open the doors faster and with almost half the required force as compared to the arm-like accessory. Also, smaller spherical wheels were found to be best in terms of reaction forces on the wheels. Prototypes based on the arc-shaped accessory design will be manufactured and evaluated for pushing doors open and dodging or gliding other obstacles.

  6. Door valve for fuel handling path

    International Nuclear Information System (INIS)

    Makishima, Katsuhiko.

    1969-01-01

    A door valve is provided which seals cover gas from a liquid metal cooled reactor without leakage therefrom. A threaded shaft is screwed into a heavy box press which is packed with lead. The shaft is adapted to be rotated by an electric motor or a manually operated wheel which is disposed outside of the door valve. A valve plate is suspended from the box press by four guide wheels mounted thereon. The guide wheels are fitted into inclined guide grooves formed at the valve plate and into grooved formed in the inner wall of a valve casing. A locking ball is provided at each side of the valve plate. In operation the shaft rotates and travels to permit the box press and the valve plate to move into the door valve casing, thus releasing the locking balls. The valve plate does not contact the bottom of the casing. When the box press reaches the home position, the valve plate is carried on the valve opening, and the box press presses the valve plate to increase the tightness. The valve plate does not suffer wear as it does not slide over other parts. (Yamaguchi, T.)

  7. Sweet Spots and Door Stops

    Science.gov (United States)

    Thompson, Michael; Tsui, Stella; Leung, Chi Fan

    2011-01-01

    A sweet spot is referred to in sport as the perfect place to strike a ball with a racquet or bat. It is the point of contact between bat and ball where maximum results can be produced with minimal effort from the hand of the player. Similar physics can be applied to the less inspiring examples of door stops; the perfect position of a door stop is…

  8. Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling.

    Directory of Open Access Journals (Sweden)

    Kristofer Davie

    2015-02-01

    Full Text Available Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs. When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically detectable as nucleosome-depleted regions or accessible/open chromatin. Here we ask whether open chromatin profiling can be used to identify the entire repertoire of active promoters and enhancers underlying tissue-specific gene expression during normal development and oncogenesis in vivo. To this end, we first compare two different approaches to detect open chromatin in vivo using the Drosophila eye primordium as a model system: FAIRE-seq, based on physical separation of open versus closed chromatin; and ATAC-seq, based on preferential integration of a transposon into open chromatin. We find that both methods reproducibly capture the tissue-specific chromatin activity of regulatory regions, including promoters, enhancers, and insulators. Using both techniques, we screened for regulatory regions that become ectopically active during Ras-dependent oncogenesis, and identified 3778 regions that become (over-activated during tumor development. Next, we applied motif discovery to search for candidate transcription factors that could bind these regions and identified AP-1 and Stat92E as key regulators. We validated the importance of Stat92E in the development of the tumors by introducing a loss of function Stat92E mutant, which was sufficient to rescue the tumor phenotype. Additionally we tested if the predicted Stat92E responsive regulatory regions are genuine, using ectopic induction of JAK/STAT signaling in developing eye discs, and observed that similar chromatin changes indeed occurred. Finally, we determine that these are functionally significant regulatory changes, as nearby target genes are up- or down-regulated. In conclusion, we show that FAIRE-seq and ATAC-seq based open chromatin profiling

  9. The insulin secretory action of novel polycyclic guanidines: discovery through open innovation phenotypic screening, and exploration of structure-activity relationships.

    Science.gov (United States)

    Shaghafi, Michael B; Barrett, David G; Willard, Francis S; Overman, Larry E

    2014-02-15

    We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, 1-3, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of 9h, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  10. A Door-to-Door Combined Transport Planner

    DEFF Research Database (Denmark)

    Aastrup, Jesper; Jespersen, Per Homann; Pedersen, Michael B.

    2004-01-01

    Establishing a web-based portal functioning as a one-stop-shop for transport buyers is a radical idea of a consumer oriented intermodal freight system. This utopian vision will be materialized in a system description and a prototype of a Door-to-Door Combined Trans-port Planner (COTRAP), developed......- and inter-organizational barriers to the establishment of a competitive and effective combined transport system with rail freight operators as the intermodal integrator. In this paper we describes the ideas and methodology behind the project, as well as some preliminary results....

  11. Koperemissies door drinkwaterleidingen (herziene editie)

    NARCIS (Netherlands)

    Verweij W; Mons MN; Aalbers JEM; Cruchten RGH van; LWD

    1996-01-01

    Ge-inventariseerd werd wat er bekend is over de fluxen van koper door (corrosie van) waterleidingen naar rioolwaterzuiveringsinstallaties (rwzi's), rwzi-slib en het oppervlaktewater. Gebleken is dat in 1993 (landelijk gemiddeld) 57% van de koperbelasting van rwzi's afkomstig is van

  12. News Teaching Support: New schools network launched Competition: Observatory throws open doors to a select few Festival: Granada to host 10th Ciencia en Acción Centenary: Science Museum celebrates 100 years Award: Queen's birthday honour for science communicator Teacher Training: Training goes where it's needed Conference: Physics gets creative in Christchurch Conference: Conference is packed with ideas Poster Campaign: Bus passengers learn about universe Forthcoming events

    Science.gov (United States)

    2009-09-01

    Teaching Support: New schools network launched Competition: Observatory throws open doors to a select few Festival: Granada to host 10th Ciencia en Acción Centenary: Science Museum celebrates 100 years Award: Queen's birthday honour for science communicator Teacher Training: Training goes where it's needed Conference: Physics gets creative in Christchurch Conference: Conference is packed with ideas Poster Campaign: Bus passengers learn about universe Forthcoming events

  13. [When doors slam, fingers jam!].

    Science.gov (United States)

    Claudet, I; Toubal, K; Carnet, C; Rekhroukh, H; Zelmat, B; Debuisson, C; Cahuzac, J-P

    2007-08-01

    Epidemiological analysis in a universitary paediatric emergency unit of children admitted after accidental injuries resulting from fingers crushed in a door. Prospective, descriptive cohort study from September 6th, 2004 to July 1st, 2005 included all children admitted for finger injuries crushed in a non-automatic door. included accidents due to automatic doors, toy's or refrigerator doors, families who refused to participate to the study or families who had left the waiting area before medical examination. Collected data were patient and family characteristics, accident characteristics and its management. Three hundred and forty children affected by 427 digital lesions were included. The mean age was 5.5+/-3.8 years (range 4 months - 15.5 years). Male/female ratio was equal to 1.2: 1. Fifty-eight percent of patients belonged to families composed of 3 or more siblings. Ninety-three per cent of families came to hospital within the first 2 hours after the accident (mean delay 99+/-162 min, median range 54 minutes). Location of the accident was: domestic (62%, at home (64%)), at school (17%). Locations within the home were: the bedroom (33%), bathroom and toilets (21%). An adult was present in 75% of cases and responsible for the trauma in 25% of accidents, another child in 44%. The finger or fingers were trapped on the hinge side in 57% of patients. No specific safeguard devices were used by 94% of families. Among victims, 20% had several crushed digits; left and right hand were injured with an equal frequency. The commonest involved digits were: the middle finger (29%), the ring finger (23%). The nail plate was damaged in 60% of digital lesions, associated with a wound (50%), a distal phalanx fracture (P3) (12%). Six children had a partial or complete amputation of P3, 2 children a lesion of the extensor tendon, 1 child had a rupture of the external lateral ligament. Three percent of children required an admission to the paediatric orthopaedic surgery unit. Post

  14. Locked doors in acute inpatient psychiatry: a literature review.

    Science.gov (United States)

    van der Merwe, M; Bowers, L; Jones, J; Simpson, A; Haglund, K

    2009-04-01

    Many acute inpatient psychiatric wards in the UK are permanently locked, although this is contrary to the current Mental Health Act Code of Practice. To conduct a literature review of empirical articles concerning locked doors in acute psychiatric inpatient wards, an extensive literature search was performed in SAGE Journals Online, EBM Reviews, British Nursing Index, CINAHL, EMBASE Psychiatry, International Bibliography of the Social Sciences, Ovid MEDLINE, PsycINFO and Google, using the search terms 'open$', 'close$', '$lock$', 'door', 'ward', 'hospital', 'psychiatr', 'mental health', 'inpatient' and 'asylum'. A total of 11 empirical papers were included in the review. Both staff and patients reported advantages (e.g. preventing illegal substances from entering the ward and preventing patients from absconding and harming themselves or others) and disadvantages (e.g. making patients feel depressed, confined and creating extra work for staff) regarding locked doors. Locked wards were associated with increased patient aggression, poorer satisfaction with treatment and more severe symptoms. The limited literature available showed the urgent need for research to determine the real effects of locked doors in inpatient psychiatry.

  15. Design And Implementation Of A Door Locking System Using Android App

    Directory of Open Access Journals (Sweden)

    Agbo David O.

    2017-08-01

    Full Text Available The Android Operating System finds wide use in smart phones and tablets and is thus suitable for home controllers. This project presents a smart home controller that uses the Bluetooth in an Android device to control the operation of an automated security door system. The software was designed using an Android app that generates a password that is recognized by the Bluetooth to control the opening and closing of the door located at some distance from the user. The Bluetooth module that is installed on the door receives the commands from the android phone and passes these commands to the microcontroller that controls the opening and closing of the door. The design was simulated in Proteus integrated development environment after which the hardware was built on experimental boards. The performance of the system agrees excellently with its conception. The system can be used in various situations where access to an enclosure need to be secured

  16. Design of the shield door and transporter for the Culham Conceptual Tokamak Reactor Mark II

    International Nuclear Information System (INIS)

    Guthrie, J.A.S.

    1980-04-01

    In the Culham Conceptual Tokamak Reactor MK II access to the interior for blanket maintenance is through large openings in the fixed shield structure closed by removable shield doors when the reactor is operational. This report describes the design of the 200 tonne doors and the associated special-purpose remote operating transporter manipulator. The design, which has not been optimised, generally uses available commercial equipment and state-of-the-art techniques. (U.K.)

  17. Scott Brothers Windows and Doors Information Sheet

    Science.gov (United States)

    Scott Brothers Windows and Doors (the Company) is located in Bridgeville, Pennsylvania. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Pittsburgh, Pennsylvania.

  18. Holiday Door Decorating Contest Brings Cheer | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer Other than the time of year, what do the following have in common: the leg lamp from the movie “A Christmas Story,” a compilation of silly holiday jokes, a gingerbread house, and Santa on a motorcycle? All four were among the individual door winners for the Holiday Door Decorating Contest, held at NCI at Frederick in December. Employees dressed up their office doors, hallways, and even stairwells to participate. Entries for the contest included individual office doors as well as groups. Some employees even “decked the halls” of whole office buildings to participate.

  19. Discovery Mondays

    CERN Multimedia

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  20. Extensivering van de begeleiding door het inzetten van peer- en self-assessment in IMTO

    NARCIS (Netherlands)

    Joosten-ten Brinke, Desirée

    2011-01-01

    Joosten-ten Brinke, D. (2011). Extensivering van de begeleiding door het inzetten van peer- en self-Assessment in IMTO. In E. Bakker, W. Giesbertz, J. von Grumbkow, & T. Houtmans (Red.), Ontwikkeling van de onderzoekscompetentie aan de Open Universiteit (pp. 121-128). Heerlen: Open universiteit.

  1. Investigation into the acceptability of door locking to staff, patients, and visitors on acute psychiatric wards.

    Science.gov (United States)

    Muir-Cochrane, Eimear; van der Merwe, Marie; Nijman, Henk; Haglund, Kristina; Simpson, Alan; Bowers, Len

    2012-02-01

    There is disagreement among psychiatric professionals about whether the doors of acute psychiatric wards should be kept locked to prevent patients from leaving and harming themselves or others. This study explored patient, staff, and visitor perceptions about the acceptability of locking the ward door on acute psychiatric inpatient wards. Interviews were conducted with 14 registered nurses, 15 patients, and six visitors from three different acute wards. Findings revealed commonalities across all groups, with general agreement that locking the door reduced absconding. Staff expressed feelings of guilt, embarrassment, and fear of being blamed when a patient absconded. Staff also reported that open wards created anxious vigilance to prevent an abscond and increased workload in allocating staff to watch the door, whereas staff on partially-locked doors also perceived an increased workload in letting people in and out of the ward. Patients had mixed feelings about the status of the door, expressing depression, a sense of stigma, and low self-esteem when the door was locked. The issue of balancing safety and security on acute psychiatric wards against the autonomy of patients is not easily resolved, and requires focused research to develop innovative nursing practices. © 2011 The Authors. International Journal of Mental Health Nursing © 2011 Australian College of Mental Health Nurses Inc.

  2. 29 CFR 1917.114 - Cargo doors.

    Science.gov (United States)

    2010-07-01

    ... counterweights shall be guarded. (2) Lift trucks and cranes shall not be used to move mechanically operated doors.... (1) The door shall be connected to its lifting tackle with shackles or equally secure means. (2) Lifting bridles and tackles shall have a safety factor of five, based upon maximum anticipated static...

  3. The Ins and Outs of Modern Doors.

    Science.gov (United States)

    College Planning & Management, 1999

    1999-01-01

    Discusses the qualities and trends in modern metal doors for educational facilities that include fire protection and sound-control attributes. Important differences in door manufacturing methods and materials are addressed and sound-transmission class values, ratings, and rating descriptions are listed. (GR)

  4. A Foot Operated Timeout Room Door Latch.

    Science.gov (United States)

    Foxx, R. M.; And Others

    1982-01-01

    This report describes the design and implementation of a foot operated timeout room door latch that permits staff members to maintain a misbehaving retarded individual in timeout without locking the door. Use of the latch also frees the staff member involved to record behavioral observations or reinforce appropriate behavior. (Author)

  5. Taksterfte in Buxus, veroorzaakt door Cylindrocladium buxicola

    NARCIS (Netherlands)

    Kuik, van A.J.; Dalfsen, van P.

    2010-01-01

    De laatste jaren wordt de Buxusteelt geplaagd door een ziekte die veroorzaakt wordt door de schimmel Cylindrocladium buxicola. Gezien de snelle uitbreiding van de ziekte is het voor kwekers en afnemers van Buxus van groot belang dat deze problematiek wordt aangepakt. Daar om is begin 2006 in

  6. Bunker door interlock limit issues of K-130 cyclotron, VECC

    International Nuclear Information System (INIS)

    Srihari, K.; Ravishankar, R.; Mitra, M.S.; Mishra, S.K.; Bandyopadhyay, T.; Sarkar, P.K.

    2011-01-01

    The K-130 cyclotron is in operation at VECC, Kolkata. Recently modernization of the cyclotron has taken place. Central region modification has increased reasonable internal beam current. During the tuning of the projectiles, loss of beam is unavoidable and projectiles hitting different parts of the machine inside the vacuum chamber . These interactions produce prompt radiation comprising neutron and gamma. However machine bunker is not accessible during the operation of the machine. The induced activity produced because of interactions of the primary and secondary radiation a radiation hazardous environment during the shut down for the related maintenance work. Area radiation monitors placed at machine bunker room have the interlock with massive shield door of the bunker. Area radiation monitors are set to specified limiting value, lower than that will allow to open the shield door in normal condition. As, the internal beam current being increased and the probability of beam spread being more. Consequently generation of induced activity is also high leading to delay in machine bunker door opening because of the interlock settings. Radiation dose mapping after a long operation of the machine was done for the different strategic points (The locations mainly people access immediate after shut down). Different consequences and remedial measures being presented in paper to raise the dose rate limit level for the interlocks between the area radiation monitors with machine bunker door, keeping in mind of the regulatory requirements. Raising the limit of dose rate limiting value will minimize the waiting time to access the machine bunker which will increase the duty factor of the machine. (author)

  7. An unexpected knock on Corrigan's secret door.

    Science.gov (United States)

    Woywodt, Alexander

    2010-10-01

    Corrigan's secret door describes a metaphorical escape route for busy physicians. The term was derived from the successful and exceptionally busy professional life of Irish physician Dominic John Corrigan (1802-80). It is claimed that Corrigan's outpatient clinic was so busy that he required a secret door in his consulting rooms to escape from the ever-growing queue of eager patients. The origins of this charming story are unknown, and the door may have never existed. However, at present, Corrigan's secret door is often quoted when busy physicians have their own little ways in surviving a stressful professional life. Generations of British-trained doctors have grown up with Corrigan's secret door, as it was featured in the introduction of the Oxford Handbook of Clinical Medicine. Accordingly, trainees as well as more senior doctors are often reminded that having a 'secret door' is vital in surviving in the medical profession. My own escape is through classical music and the violoncello, in particular. As the name implies, my own secret door is normally invisible to colleagues and patients. This little article is about a patient who found me out, and a reflection on the role of classical music and the cello in my professional life.

  8. The Open Access Dilemma

    Science.gov (United States)

    Pratt, Timothy

    2017-01-01

    Community colleges, with their commitment to open access, admit millions of students each year who are unprepared for college-level work, even though they have earned a high-school diploma. For decades the schools had a built-in base of students attracted to their open doors and relative affordability. But enrollment at public two-year college has…

  9. Special sliding door with storable handrail to support senior and handicapped persons to walk by themselves

    Science.gov (United States)

    Saitou, K.; Noda, N.-A.; Sano, Y.; Takase, Y.; Murai, K.; Wang, Z. F.; Li, S. Q.; Liu, X.; Tanaka, H.; Kubo, Y.

    2018-06-01

    In this paper, special sliding door is designed in order to support senior and handicapped persons to walk by themselves in hospitals and nursing facilities. This semiautomatic lifting equipment is utilized for the storable handrail to make sure the bad health persons are able to open the door by using a weak force. In this study, to design the equipment of the handrail, the theoretical formula of opening force is derived. Then the simulation is performed by varying geometrical conditions. The simulation results are compared with the experiment results.

  10. FDS5 Simulation for OECD PRISME Fire Test of DOOR PRSD5

    International Nuclear Information System (INIS)

    Lee, Kyu Bok; Park, Jong Seuk

    2009-01-01

    OECD/NEA PRISME Fire Project is an international co-operation project to investigate fire propagation by means of experiments and analyses for nuclear power plant applications. This project focuses on the generation of experimental data for fire and smoke propagation from the fire room to adjacent rooms under various conditions and room configurations. In addition, analyses using computer codes are performed to understand the phenomena of interest and to produce a consistent interpretation of the experimental results. The PRISME Project is composed of series of tests named as SOURCE, DOOR, LEAK and Global Tests. The SOURCE is composed of tests to characterize the fire source, and the DOOR is to study fire and smoke propagation through an open door, while the LEAK is to investigate hot gas leakages through other modes of openings such as holes, a slot, a duct, and a partially opened door. The Global test will be conducted as integral tests on the basis of the results of the previous separate effects tests. In this paper, simulations are performed with FDS5 computer code for the DOOR Test No.5 (PRS D 5) and the calculation results are compared with the corresponding experimental data to study the code capability to predict the phenomena of the hot gas propagation between two rooms

  11. Vraaggericht werken door narratief onderzoek

    Directory of Open Access Journals (Sweden)

    Joos Meesters

    2010-09-01

    Full Text Available Narrative research as a means for demand-driven policy and interventions This article reports on the advantages of performing narrative research discovering need patterns of families, children, local residents regarding quality of the pedagogical climate in their neighbourhood. A need pattern is a constructed set of related questions and needs that people express in response to life events, concrete experiences or within their current habitat. A method for narrative analysis was developed for two applications: use as a research tool and use as a change management tool. In this method professionals assume the role of narrative researchers and simultaneously learn to listen to the demands and needs of their potential clients from a more objective perspective. The method has been developed while performing transdisciplinary narrative research in the town-area of Hatert in Nijmegen, which will be presented as an example case throughout the text. Vraaggericht werken door narratief onderzoek Dit artikel gaat in op de mogelijkheden van narratief onderzoek in het opsporen van vraagpatronen van gezinnen, kinderen, wijkbewoners met betrekking tot de kwaliteit van het opgroeiklimaat in hun wijk. Een vraagpatroon is een set van samenhangende vragen en behoeften die burgers uiten naar aanleiding van een levensgebeurtenis, een concrete ervaring of binnen de actuele context waar zij in leven. Voor deze vorm van onderzoek is een vraaganalyse-instrument ontwikkeld om deze vraagpatronen te identificeren. Dit instrument heeft een dubbel perspectief. Het is een onderzoeksinstrument en een veranderkundig instrument. De professional kruipt in de rol van onderzoeker en leert hiermee te luisteren naar de vragen en behoeften van burgers. Het instrument is ontwikkeld in en voor een transdisciplinair, narratief onderzoek in de wijk Hatert in Nijmegen, dat we als casus zullen presenteren.

  12. Influence of the Pressure Difference and Door Swing on Heavy Contaminants Migration between Rooms.

    Science.gov (United States)

    Hendiger, Jacek; Chludzińska, Marta; Ziętek, Piotr

    2016-01-01

    This paper presents the results of investigations whose aim was to describe the influence of the pressure difference level on the ability of contaminants migration between neighbouring rooms in dynamic conditions associated with door swing. The analysis was based on airflow visualization made with cold smoke, which simulated the heavy contaminants. The test room was pressurized to a specific level and then the door was opened to observe the trail of the smoke plume in the plane of the door. The door was opened in both directions: to the positively and negatively pressurized room. This study focuses on the visualization of smoke plume discharge and an uncertainty analysis is not applicable. Unlike other studies which focus on the analysis of pressure difference, the present study looks at the contaminants which are heavier than air and on "pumping out" the contaminants by means of door swing. Setting the proper level of pressure difference between the contaminated room and the neighbouring rooms can prove instrumental in ensuring protection against toxic contaminants migration. This study helped to establish the threshold of pressure difference necessary to reduce migration of heavy contaminants to neighbouring rooms.

  13. Electric two wheelers, zero emission solution for urban door to door transportation

    DEFF Research Database (Denmark)

    Fasil, Muhammed; Jensen, Bogi Bech

    The noise and exhaust pollution coupled with increasing congestion faced by urban centres demands new personal mobility solution for faster door to door connectivity. The advancement in electric power train and lowering cost of Li-ion battery is made it possible to develop light weight fully...

  14. Comparing energy use and environmental emissions of reinforced wood doors and steel doors

    Science.gov (United States)

    Lynn Knight; Melissa Huff; Janet I. Stockhausen; Robert J. Ross

    2005-01-01

    The USDA Forest Service Forest Products Laboratory has patented a technology that incorporates fiberglass-reinforced wood into the structure of wood doors and other wood building products. The process of reinforcing wood doors with epoxy and fiberglass increases the strength and durability of the product. Also, it allows the use of low-value, small-diameter wood which...

  15. The Globe opens its doors to the public

    CERN Multimedia

    2005-01-01

    The Globe of Science and Innovation has quickly become the most recognisable landmark on the CERN skyline. Since construction was completed last summer, the Globe's distinctive spherical shape has greeted and intrigued visitors and employees on arrival at CERN.

  16. Door still open for action on issue of global warming

    International Nuclear Information System (INIS)

    Crow, P.

    1992-01-01

    Global warming may or may not be a legitimate environmental threat, but Washington lobbyists consider it a legislative threat. It does not appear the current Congress will limit or tax use of U.S. fossil fuels, whose burning releases carbon dioxide into the atmosphere. This paper reports that some scientists have claimed a concentration of greenhouse gases in the atmosphere will result in a significant warming of the earth by 2050, threatening agriculture, altering ecosystems, and even melting polar ice and causing rising oceans to flood coastal areas and islands. In 1990 a United Nations panel of climate scientists predicted a 2 degrees C. increase in world temperatures within 35 years and 6 degrees by the end of the next century. Some scientists say preventing further increases will require a 60% reduction in current CO 2 emissions. The oil industry already is beginning to feel heat from the global warming issue. The Environmental Protection Agency calculates energy production and use is responsible for 57% of current emissions caused by man

  17. Opening Doors to Nursing Degrees: A Proposal from Ontario's Colleges

    Science.gov (United States)

    Colleges Ontario, 2010

    2010-01-01

    Ontario needs to expand nursing education options to improve access to the nursing profession, create better pathways amongst all nursing occupations, and build Ontario's capacity to meet the province's long-term nursing needs. Ontario's colleges are capable of playing a larger role within a long-term provincial strategy for sustaining and…

  18. Cold fusion: Need to keep door wide open

    International Nuclear Information System (INIS)

    Jones, S.E.

    1992-01-01

    Steven E. Jones of Brigham Young University in Provo, Utah, began work on cold fusion in 1986. Although insisting his work is markedly different from that of Stanley Pons and Martin Fleischmann at the nearby University of Utah, he nevertheless was tarred by the same brush that besmirched their sensational revelations in 1989. Whereas we were searching for tiny nuclear effects, they were looking for heat production, he explains. In no way, he insists, does his work substantiate the bold claims of heat generation by cold fusion in an electrochemical cell. In fact, Jones doublts Fleischmann and Pons' claims and sees evidence of either self-deception or hype in their actions. He adds, For useful energy production, thermonuclear (hot) fusion remains for more promising than that cold fusion claims of Pons and Fleischmann. But at the same time, Jones finds it necessary to appeal for tolerance for researchers brave enough to continue in the now unfashionable field of cold fusion

  19. Towards Constructive Foundations of Cognitivism: Breaking in Open Doors?

    Czech Academy of Sciences Publication Activity Database

    Wiedermann, Jiří

    2013-01-01

    Roč. 9, č. 1 (2013), s. 38-40 ISSN 1782-348X Institutional support: RVO:67985807 Keywords : constructive cognitivism * diffusion search algorithm * amorphous computing system Subject RIV: IN - Informatics, Computer Science http://www.univie.ac.at/constructivism/journal/9/1/038.wiedermann

  20. Global reach: international doors wide open to Canadians

    International Nuclear Information System (INIS)

    Lorenz, A.

    2000-01-01

    Opportunities available to Canadian companies abroad, particularly in the oil and gas field service sector, are reviewed. The overall conclusion is that while in some parts of the world, such as the Middle East negotiating contracts may be a challenge, the problem can be overcome by hiring a reliable local agent who speaks the language and is familiar with local business practices. The process is often time-consuming and requires a great deal of patience, but the opportunities are there to exploit. The excellent reputation of Canadian businessmen for for honesty and high quality of service makes it all possible

  1. Twitter and Facebook Open the Door to Collaboration

    Science.gov (United States)

    Huwe, Terence K.

    2012-01-01

    Building a social media profile itself is a rewarding experience for digital librarians, but there is another aspect to social media immersion, and it is a powerful tool for the profession. As librarians establish expert status in the use of popular tools such as Facebook, Twitter, Tumblr, and WordPress, they can add training and even product…

  2. Philosophy: A Key To Open the Door to Critical Thinking.

    Science.gov (United States)

    Clarke, David J.; Holt, Janet

    2001-01-01

    A learning module for nursing attempts to prepare nurses to understand philosophical inquiry and develop critical thinking skills. Teaching strategies used included exercises involving verbal disagreement and ambiguity and critical examination of publications. (Contains 42 references.) (SK)

  3. Opening Doors to Cryospheric Data and Information, Virtually

    Science.gov (United States)

    Pharris, K.; Ballagh, L. M.; Swick, R.; Zaffino, P.

    2006-12-01

    Via Google Earth, the National Snow and Ice Data Center (NSIDC) is demonstrating different methods of data presentation-visualization, animation and pinpointing of in situ data-to create new opportunities for those who currently provide and use cryospheric data and to empower Google Earth users with information to make their own decisions about hot topics such as climate change. Using visualization capabilities within Google Earth and the Keyhole Markup Language (KML), NSIDC has made images of glaciers, sea ice, snow and permafrost display over the globe. NSIDC is also creating animations within Google Earth for gridded, time-series data sets. These animations could, for example, demonstrate how sea ice extent has fluctuated over time. In situ data accessible through Google Earth enables users to locate and view cryospheric data using a common search criteria, spatial coverage. This fly-and-click functionality makes it easier for users to sort through ever-increasing amounts of data. The access to and visualization of data within Google Earth can expose new audiences to different applications of cryospheric data, enabling researchers in other scientific disciplines, commercial consultants and engineers, policy makers, educators and students to apply cryospheric information to their work. Google Earth also makes it possible to educate users in context and provide a multi-sensory learning experience. For example, users can view glaciers in the context of where they exist, see images of the formations, and access data and additional reference material.

  4. Cabinet chooses TNK-BP, but doors remain open

    Index Scriptorium Estoniae

    2005-01-01

    Leedu valitsus alustab Vene-Suurbritannia ühisfirmaga TNK-BP läbirääkimisi Mazeikiu Nafta aktsiaenamuse omandamiseks. Kuid samal ajal on võimalik alustada läbirääkimisi ka teiste võimalike investoritega

  5. Global reach: international doors wide open to Canadians

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, A.

    2000-05-01

    Opportunities available to Canadian companies abroad, particularly in the oil and gas field service sector, are reviewed. The overall conclusion is that while in some parts of the world, such as the Middle East negotiating contracts may be a challenge, the problem can be overcome by hiring a reliable local agent who speaks the language and is familiar with local business practices. The process is often time-consuming and requires a great deal of patience, but the opportunities are there to exploit. The excellent reputation of Canadian businessmen for for honesty and high quality of service makes it all possible.

  6. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    The price discovery literature investigates how homogenous securities traded on different markets incorporate information into prices. We take this literature one step further and investigate how these markets contribute to stochastic volatility (volatility discovery). We formally show...... that the realized measures from homogenous securities share a fractional stochastic trend, which is a combination of the price and volatility discovery measures. Furthermore, we show that volatility discovery is associated with the way that market participants process information arrival (market sensitivity......). Finally, we compute volatility discovery for 30 actively traded stocks in the U.S. and report that Nyse and Arca dominate Nasdaq....

  7. Design and Construction of Pool Door for Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Kwangsub; Lee, Sangjin; Choi, Jinbok; Oh, Jinho; Lee, Jongmin [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The pool door is a structure to isolate the reactor pool from the service pool for maintenance. The pool door is installed before the reactor pool is drained. The pool door consists of structural component and sealing component. The main structures of the pool door are stainless steel plates and side frames. The plates and frames are assembled by welded joints. Lug is welded at the top of the plate. The pool door is submerged in the pool water when it is used. Materials of the pool door should be resistive to corrosion and radiation. Stainless steel is used in structural components and air nozzle assemblies. Features of design and construction of the pool door for the research reactor are introduced. The pool door is designed to isolate the reactor pool for maintenance. Structural analysis is performed to evaluate the structural integrity during earthquake. Tests and inspections are also carried out during construction to identify the safety and function of the pool door.

  8. Design and Construction of Pool Door for Research Reactor

    International Nuclear Information System (INIS)

    Jung, Kwangsub; Lee, Sangjin; Choi, Jinbok; Oh, Jinho; Lee, Jongmin

    2016-01-01

    The pool door is a structure to isolate the reactor pool from the service pool for maintenance. The pool door is installed before the reactor pool is drained. The pool door consists of structural component and sealing component. The main structures of the pool door are stainless steel plates and side frames. The plates and frames are assembled by welded joints. Lug is welded at the top of the plate. The pool door is submerged in the pool water when it is used. Materials of the pool door should be resistive to corrosion and radiation. Stainless steel is used in structural components and air nozzle assemblies. Features of design and construction of the pool door for the research reactor are introduced. The pool door is designed to isolate the reactor pool for maintenance. Structural analysis is performed to evaluate the structural integrity during earthquake. Tests and inspections are also carried out during construction to identify the safety and function of the pool door

  9. The doors have been removed… for YOUR safety

    DEFF Research Database (Denmark)

    Abildgaard, Mette Simonsen

    on the classic box-shaped telephone booths, which had been a part of Danish communication infrastructure since 1932. But the doors were never reinstalled after the capture of the user, who became known as The Telephone Bomber, and a competition for a new open design was commissioned in 1980. The winning design......'s shape in fact made it inoperable for wheelchair-users. In contrast, the mayor of Copenhagen was fond of The Question Mark and vetoed alternative designs. Following several years of dispute, The Question Mark was installed in central Copenhagen, and Utzon Arkitekter, firm of Jørn Utzon, were commissioned...... to design a second open telephone booth. The Utzon-booth was ready in 1987, and received favourable reactions from the public on its design, which drew on the classic box-shape. I will present how, between human and nonhuman actors, in such different domains as politics, design, infrastructure and terror...

  10. Self-testing security sensor for monitoring closure of vault doors and the like

    International Nuclear Information System (INIS)

    Cawthorne, D.C.

    1997-01-01

    A self-testing device is provided for a monitoring system for monitoring whether a closure member such as a door or window is closed. The monitoring system includes a switch unit mounted on the frame of the closure member being monitored and including magnetically biased switches connected in one or more electrical monitoring circuits, and a door magnet unit mounted on the closure member being monitored. The door magnet includes one or more permanent magnets that produce a magnetic field which, when the closure member is closed, cause said switches to assume a first state. When the closure member is opened, the switches switch to a second, alarm state. The self-testing device is electrically controllable from a remote location and produces a canceling or diverting magnetic field which simulates the effect of movement of the closure member from the closed position thereof without any actual movement of the member. 5 figs

  11. De fietsstraat : Onderzoek naar fietsverbindingen door verblijfsgebieden

    NARCIS (Netherlands)

    Andriesse, H.C.; Hansen, J.A.

    1996-01-01

    De bestaande fietsverbindingen in de stad lopen meestal langs doorgaande wegen met druk autoverkeer. Door de toename van het autoverkeer zijn deze verbindingen niet altijd meer de meest geschikte fietsvoorzieningen. Ook de maatregelen die in het kader van duurzaam veilig wegverkeer worden

  12. Maillard-reactie door model beheersbaar

    NARCIS (Netherlands)

    Roost, van M.

    2006-01-01

    Gewenste en ongewenste bruinkleuring van levensmiddelen door een Maillard-reactie is vaak lastig te beheersen. Wageningse onderzoekers ontwikkelden een simulatiemodel, waarmee producentenmeer inzicht krijgen in de Maillard-reactie, en zo ook de kleur van het eindproduct beter kunnen beheersen

  13. Gaffkemia van kreeften door Aerococcus viridans

    NARCIS (Netherlands)

    Engelsma, M.Y.; Haenen, O.L.M.

    2011-01-01

    Artikel over een bacteriële ziekte van onder andere kreeften, de zogenaamde Gaffkemia, veroorzaakt door de bacterie Aerococcus viridans. Deze ziekte is in Nederland nog niet eerder gevonden bij kreeften, maar zou met importen van kreeftachtigen mee kunnen komen.

  14. Gezondheidsschade door calamiteiten met gevaarlijke stoffen

    NARCIS (Netherlands)

    Weger, D. de; Feron, V.J.; Zwart, A.; Vrijer, F. de

    1993-01-01

    Door de Afdeling Industriële Veiligheid van IMET-TNO (Instituut voor Milieu- en Energietechnologie, Hoofdgroep Milieu en Energie te Apeldoorn) en de Afdeling Biologische Toxicologie van ITV-TNO (Instituur voor Toxicologie en voeding, Hoofdgroep Voeding te Zeist) is het project 'Gezondheidsschade

  15. 14 CFR 25.783 - Fuselage doors.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuselage doors. 25.783 Section 25.783 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... operated manually; (ii) The powered latch actuators, if installed; and (iii) The relative motion between...

  16. Doors for memory: A searchable database.

    Science.gov (United States)

    Baddeley, Alan D; Hitch, Graham J; Quinlan, Philip T; Bowes, Lindsey; Stone, Rob

    2016-11-01

    The study of human long-term memory has for over 50 years been dominated by research on words. This is partly due to lack of suitable nonverbal materials. Experience in developing a clinical test suggested that door scenes can provide an ecologically relevant and sensitive alternative to the faces and geometrical figures traditionally used to study visual memory. In pursuing this line of research, we have accumulated over 2000 door scenes providing a database that is categorized on a range of variables including building type, colour, age, condition, glazing, and a range of other physical characteristics. We describe an illustrative study of recognition memory for 100 doors tested by yes/no, two-alternative, or four-alternative forced-choice paradigms. These stimuli, together with the full categorized database, are available through a dedicated website. We suggest that door scenes provide an ecologically relevant and participant-friendly source of material for studying the comparatively neglected field of visual long-term memory.

  17. Development of a tornado safe room door from wood Products: door design and impact testing

    Science.gov (United States)

    Robert H. Falk; James J. Bridwell

    2016-01-01

    In this study, a tornado safe room door built from wood products and steel sheeting was developed and impact-tested according to tornado safe room standards. Results indicate that an door constructed from as few as two sheets of 23/32-in. (18.26-mm) construction-grade plywood and overlaid with 18-gauge (0.05-in.- (1.27- mm-) thick) steel can pass the required impact...

  18. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2017-01-01

    In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...

  19. Chemical Discovery

    Science.gov (United States)

    Brown, Herbert C.

    1974-01-01

    The role of discovery in the advance of the science of chemistry and the factors that are currently operating to handicap that function are considered. Examples are drawn from the author's work with boranes. The thesis that exploratory research and discovery should be encouraged is stressed. (DT)

  20. Door Security using Face Detection and Raspberry Pi

    Science.gov (United States)

    Bhutra, Venkatesh; Kumar, Harshav; Jangid, Santosh; Solanki, L.

    2018-03-01

    With the world moving towards advanced technologies, security forms a crucial part in daily life. Among the many techniques used for this purpose, Face Recognition stands as effective means of authentication and security. This paper deals with the user of principal component and security. PCA is a statistical approach used to simplify a data set. The minimum Euclidean distance found from the PCA technique is used to recognize the face. Raspberry Pi a low cost ARM based computer on a small circuit board, controls the servo motor and other sensors. The servo-motor is in turn attached to the doors of home and opens up when the face is recognized. The proposed work has been done using a self-made training database of students from B.K. Birla Institute of Engineering and Technology, Pilani, Rajasthan, India.

  1. Solution for Direct Solar Impingement Problem on Landsat-7 ETM+ Cooler Door During Cooler Outgas in Flight

    Science.gov (United States)

    Choi, Michael K.

    1999-01-01

    There was a thermal anomaly of the Landsat-7 Enhanced Thematic Mapper Plus (ETM+) radiative cooler cold stage during the cooler outgas phase in flight. With the cooler door in the outgas position and the outgas heaters enabled, the cold stage temperature increased to a maximum of 323 K when the spacecraft was in the sunlight, which was warmer than the 316.3 K upper set point of the outgas heater controller on the cold stage. Also, the outgas heater cycled off when the cold stage was warming up to 323 K. A corrective action was taken before the attitude of the spacecraft was changed during the first week in flight. One orbit before the attitude was changed, the outgas heaters were disabled to cool off the cold stage. The cold stage temperature increase was strongly dependent on the spacecraft roll and yaw. It provided evidence that direct solar radiation entered the gap between the cooler door and cooler shroud. There was a concern that the direct solar radiation could cause polymerization of hydrocarbons, which could contaminate the cooler and lead to a thermal short. After outgas with the cooler door in the outgas position for seven days, the cooler door was changed to the fully open position. With the cooler door fully open, the maximum cold stage temperature was 316.3 K when the spacecraft was in the sunlight, and the duty cycle of the outgas heater in the eclipse was the same as that in the sunlight. It provided more evidence that direct solar radiation had entered the gap between the cooler door and cooler shroud. Cooler outgas continued for seven more days, with the cooler door fully open. The corrective actions had prevented overheating of the cold stage and cold focal plane array (CFPA), which could damage these two components. They also minimized the risk of contamination on the cold stage, which could lead to a thermal short.

  2. Higgs Discovery

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2013-01-01

    has been challenged by the discovery of a not-so-heavy Higgs-like state. I will therefore review the recent discovery \\cite{Foadi:2012bb} that the standard model top-induced radiative corrections naturally reduce the intrinsic non-perturbative mass of the composite Higgs state towards the desired...... via first principle lattice simulations with encouraging results. The new findings show that the recent naive claims made about new strong dynamics at the electroweak scale being disfavoured by the discovery of a not-so-heavy composite Higgs are unwarranted. I will then introduce the more speculative......I discuss the impact of the discovery of a Higgs-like state on composite dynamics starting by critically examining the reasons in favour of either an elementary or composite nature of this state. Accepting the standard model interpretation I re-address the standard model vacuum stability within...

  3. BEA Discoveries 2010: BEA beyond the Buzz

    Science.gov (United States)

    Fox, Bette-Lee; Heilbrun, Margaret; Hoffert, Barbara; Katterjohn, Anna; Kuzyk, Raya; McCormack, Heather; Rogers, Michael; Williams, Wilda

    2010-01-01

    With the exhibits at New York's Jacob K. Javits Convention Center open just two days, the show floor at this year's BEA was a real free-for-all, with lots of traffic from the moment the doors opened on Wednesday, May 26. But for LJ's review editors, it was worth enduring stubbed toes and rattled nerves to find fresh and interesting titles. In this…

  4. Real-time door detection for indoor autonomous vehicle

    Science.gov (United States)

    He, Zhihao; Zhu, Ming

    2017-07-01

    Indoor Autonomous Vehicle(IAV) is used in many indoor scenes. Such as hotels and hospitals. Door detection is a key issue to guide the IAV into rooms. In this paper, we consider door detection in the use of indoor navigation of IAV. Since real-time properties are important for real-world IAV, the detection algorithm must be fast enough. Most monocular-camera based door detection model need a perfect detection of the four line segments of the door or the four corners. But in many situations, line segments could be extended or cut off. And there could be many false detected corners. And few of them can distinguish doors from door-like objects with door-like shape effectively. We proposed a 2-D vision model of the door that is made up of line segments. The number of parts detected is used to determine the possibility of a door. Our algorithm is tested on a database of doors.1 The robustness and real-time are verified. The precision is 89.4%. Average time consumed for processing a 640x320 figure is 44.73ms.

  5. Traumatic asphyxia--fatal accident in an automatic revolving door.

    Science.gov (United States)

    Cortis, J; Falk, J; Rothschild, M A

    2015-09-01

    Due to continuing modernisation, the number of automatic doors in routine use, including powered revolving doors, has increased in recent years. Automatic revolving doors are found mostly in department stores, airports, railway stations and hospitals. Although safety arrangements and guidelines concerning the installation of automatic doors are in existence, their disregard in conjunction with obsolete or incorrect installation can lead to fatal accidents. In this report, a 19-month-old boy is described whose right arm was caught between the elements of an automatic revolving door. As a direct result of rescue attempts, the child's body was drawn further into the narrow gap between elements of the door. To get the boy's body out of the 4-cm-wide gap between the fixed outer wall of the revolving door and the revolving inner, back-up batteries had to be disconnected so as to stop the electrical motor powering the door. Cardiopulmonary resuscitation was begun immediately after the rescue but was unsuccessful; the child was declared dead at the hospital he was taken to. The cause of death was a combination of compression-related skull and brain injury together with thoracic compression. This case shows an outstanding example of the preventive aspect as a special task of forensic medicine. Additionally, it serves as a warning for the correct installation and use of automatic revolving doors. Even so, small children should not use these doors on their own, but only with an alert companion, so as to prevent further fatal accidents of this sort.

  6. DoOR 2.0 - Comprehensive Mapping of Drosophila melanogaster Odorant Responses

    Science.gov (United States)

    Münch, Daniel; Galizia, C. Giovanni

    2016-02-01

    Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add unpublished data to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include all of these datasets into DoOR, provide a comprehensive update of both code and data, and new tools for data analyses and visualizations. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.

  7. Design Report for ACP Hot Cell Rear Door

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; Kwon, K. C.; Choung, W. M.; Cho, I. J.; Kook, D. H.; Lee, W. K.; You, G. S.; Lee, E. P.; Park, S. W

    2005-12-15

    A hot-cell facility was constructed at the IMEF building for the demonstrate ACP process. ACP hot-cell consists of process cell and maintenance cell, and each cell has rear door. Since this facility was constructed at basement floor, all process materials, equipment and radioactive materials are take in and out through the rear door. Also, this door can be an access route of workers for the maintenance works. Therefore ACP hot-cell rear doors must maintain the radiation shielding, sealing, mechanical and structural safety. This report presents design criteria, design contents of each part and driving part. It was confirmed that the rear doors sufficiently maintain the safety through the structural analysis and shielding analysis. Also, it was confirmed that the rear doors were constructed as designed by the gamma scanning test after the installation.

  8. Modal analysis of pool door in water tank

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Soo; Jeong, Kyeong Hoon; Park, Chan Gook; Koo, In Soo [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    A pool door is installed at the chase of the pool gate by means of an overhead crane in the building of a research reactor. The principal function of the pool door, which is located between the reactor pool and service pool, is to separate the reactor pool from the service pool for the maintenance and/or the removal of the equipment either in the reactor pool or service pool. The pool door consists of stainless steel plates supported by structural steel frames and sealing components. The pool door is equipped with double inflatable gaskets. The configuration of the pool door is shown in Figure 1. The FEM analysis and theoretical calculation by the formula were performed to evaluate the natural frequency for the pool door in the water. The results from the two methods were compared.

  9. Design Report for ACP Hot Cell Rear Door

    International Nuclear Information System (INIS)

    Ku, J. H.; Kwon, K. C.; Choung, W. M.; Cho, I. J.; Kook, D. H.; Lee, W. K.; You, G. S.; Lee, E. P.; Park, S. W.

    2005-12-01

    A hot-cell facility was constructed at the IMEF building for the demonstrate ACP process. ACP hot-cell consists of process cell and maintenance cell, and each cell has rear door. Since this facility was constructed at basement floor, all process materials, equipment and radioactive materials are take in and out through the rear door. Also, this door can be an access route of workers for the maintenance works. Therefore ACP hot-cell rear doors must maintain the radiation shielding, sealing, mechanical and structural safety. This report presents design criteria, design contents of each part and driving part. It was confirmed that the rear doors sufficiently maintain the safety through the structural analysis and shielding analysis. Also, it was confirmed that the rear doors were constructed as designed by the gamma scanning test after the installation

  10. COMPARISON OF RESULTS OF THERMAL TESTS OF BALCONY DOORS

    Directory of Open Access Journals (Sweden)

    Golubev Stanislav Sergeevich

    2012-10-01

    Full Text Available Results of thermal tests of balcony doors are presented in the article. In the course of the research project, two types of doors were tested. The first type represents a PVC frame door (width 82 mm; it has a triple glazing (4K-16Ar-4-16Ar-K4; its blank part represents a polystyrene sandwich panel (width 40 mm. The second type represents a PVC frame door (width 82 mm, that has a triple glazing (4K-16Ar-4-16Ar-K4 and composite PVC panels. The testing procedure and processing results are described in the article. The test has demonstrated that the thermal resistance value of the balcony door of the first type exceeds the thermal resistance value of the balcony door of the second type.

  11. Psychiatric wards with locked doors--advantages and disadvantages according to nurses and mental health nurse assistants.

    Science.gov (United States)

    Haglund, K; von Knorring, L; von Essen, L

    2006-04-01

    To describe nurses' and mental health nurse assistants' perceptions of advantages and disadvantages about working on a psychiatric ward with a locked entrance door. Psychiatric staff sometimes needs to protect patients from harming themselves or others. To keep the entrance door locked may help staff to achieve this goal. How locked entrance doors at psychiatric wards are experienced by staff, working on these wards, has been investigated to a very limited extent. The study was explorative and descriptive. Audio taped, semi-structured interviews with open-ended questions about advantages and disadvantages about working on a psychiatric ward with a locked entrance door, were conducted with 20 nurses and 20 mental health nurse assistants. Data were analyzed with content analysis. A content analysis revealed eight categories of advantages and 18 categories of disadvantages. Most advantages mentioned by nurses and mental health nurse assistants were categorized as providing staff with control over patients, providing patients with a secure and efficient care and protecting patients and staff against 'the outside'. Most disadvantages mentioned by nurses were categorized as causing extra work for staff, making patients feel confined, making patients feel dependent and creating a non-caring environment. Most disadvantages mentioned by mental health nurse assistants were categorized as causing extra work for staff, making patients feel confined, causing emotional problems for patients, making staff's power obvious and forcing patients to adapt to other patients' needs. Nurses and mental health nurse assistants mentioned more disadvantages than advantages and nurses mentioned more disadvantages than mental health nurse assistants. Nurses and mental health nurse assistants perceive a number of advantages and disadvantages for themselves, patients and significant others with a locked door at a psychiatric ward. Most of these concern patients' experiences. It is important for

  12. Discovery of a general method of solving the Schrödinger and dirac equations that opens a way to accurately predictive quantum chemistry.

    Science.gov (United States)

    Nakatsuji, Hiroshi

    2012-09-18

    Just as Newtonian law governs classical physics, the Schrödinger equation (SE) and the relativistic Dirac equation (DE) rule the world of chemistry. So, if we can solve these equations accurately, we can use computation to predict chemistry precisely. However, for approximately 80 years after the discovery of these equations, chemists believed that they could not solve SE and DE for atoms and molecules that included many electrons. This Account reviews ideas developed over the past decade to further the goal of predictive quantum chemistry. Between 2000 and 2005, I discovered a general method of solving the SE and DE accurately. As a first inspiration, I formulated the structure of the exact wave function of the SE in a compact mathematical form. The explicit inclusion of the exact wave function's structure within the variational space allows for the calculation of the exact wave function as a solution of the variational method. Although this process sounds almost impossible, it is indeed possible, and I have published several formulations and applied them to solve the full configuration interaction (CI) with a very small number of variables. However, when I examined analytical solutions for atoms and molecules, the Hamiltonian integrals in their secular equations diverged. This singularity problem occurred in all atoms and molecules because it originates from the singularity of the Coulomb potential in their Hamiltonians. To overcome this problem, I first introduced the inverse SE and then the scaled SE. The latter simpler idea led to immediate and surprisingly accurate solution for the SEs of the hydrogen atom, helium atom, and hydrogen molecule. The free complement (FC) method, also called the free iterative CI (free ICI) method, was efficient for solving the SEs. In the FC method, the basis functions that span the exact wave function are produced by the Hamiltonian of the system and the zeroth-order wave function. These basis functions are called complement

  13. Door recognition in cluttered building interiors using imagery and lidar data

    Science.gov (United States)

    Díaz-Vilariño, L.; Martínez-Sánchez, J.; Lagüela, S.; Armesto, J.; Khoshelham, K.

    2014-06-01

    Building indoors reconstruction is an active research topic due to the importance of the wide range of applications to which they can be subjected, from architecture and furniture design, to movies and video games editing, or even crime scene investigation. Among the constructive elements defining the inside of a building, doors are important entities in applications like routing and navigation, and their automated recognition is advantageous e.g. in case of large multi-storey buildings with many office rooms. The inherent complexity of the automation of the recognition process is increased by the presence of clutter and occlusions, difficult to avoid in indoor scenes. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors using information acquired in the form of point clouds and images. The methodology goes in depth with door detection and labelling as either opened, closed or furniture (false positive)

  14. Door recognition in cluttered building interiors using imagery and lidar data

    Directory of Open Access Journals (Sweden)

    L. Díaz-Vilariño

    2014-06-01

    Full Text Available Building indoors reconstruction is an active research topic due to the importance of the wide range of applications to which they can be subjected, from architecture and furniture design, to movies and video games editing, or even crime scene investigation. Among the constructive elements defining the inside of a building, doors are important entities in applications like routing and navigation, and their automated recognition is advantageous e.g. in case of large multi-storey buildings with many office rooms. The inherent complexity of the automation of the recognition process is increased by the presence of clutter and occlusions, difficult to avoid in indoor scenes. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors using information acquired in the form of point clouds and images. The methodology goes in depth with door detection and labelling as either opened, closed or furniture (false positive

  15. Sequestered spaces and defective doors in tales by Collins and Riddell

    Directory of Open Access Journals (Sweden)

    Ilse M. Bussing

    2012-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2012n62p99   In nineteenth-century texts the Victorian home is not merely asetting for supernatural activity—it is the protagonist. This articleconsiders how architecture engendered and shaped hauntedspace within Gothic texts by focusing on a single feature—the door—whose symbolic charge has been widely discussedby critics. However, instead of focusing on psychoanalyticor feminist notions commonly attached to this element, thisarticle considers architectural manuals of the day in order to“read” spatial and cultural implications of the door in Victorianhouseholds, arguing that an excessive concern for privacy andconcealment in life translates easily into Gothic fiction, in theform of spatial anxiety and infiltration. The discussion centerson two literary texts: The Dead Secret (1857 by Wilkie Collinsand The Open Door by Charlotte Riddell (1882.

  16. The chatter door, designing for in-between spaces

    NARCIS (Netherlands)

    Duel, T.; Levy, P.

    2015-01-01

    The project presented in this paper is part of a broader research addressing in-between spaces and the designing of experiences taking place there. The project focuses on door frames, and inquires the way to improve social interactions taking place 'at the door'. To do so, the approach is structured

  17. Revolving Classroom Door: Management Strategies To Eliminate the Quick Spin.

    Science.gov (United States)

    Rancifer, Jesse L.

    This paper presents classroom management practices that can be used to avoid the "revolving classroom door." In the revolving classroom door, misbehaving students are sent to the principal, and eventually returned to the classroom with no gains in student behavior or opportunity for learning. The paper begins by discussing the meaning of classroom…

  18. Looking for the WIMP next door

    Science.gov (United States)

    Evans, Jared A.; Gori, Stefania; Shelton, Jessie

    2018-02-01

    We comprehensively study experimental constraints and prospects for a class of minimal hidden sector dark matter (DM) models, highlighting how the cosmological history of these models informs the experimental signals. We study simple `secluded' models, where the DM freezes out into unstable dark mediator states, and consider the minimal cosmic history of this dark sector, where coupling of the dark mediator to the SM was sufficient to keep the two sectors in thermal equilibrium at early times. In the well-motivated case where the dark mediators couple to the Standard Model (SM) via renormalizable interactions, the requirement of thermal equilibrium provides a minimal, UV-insensitive, and predictive cosmology for hidden sector dark matter. We call DM that freezes out of a dark radiation bath in thermal equilibrium with the SM a WIMP next door, and demonstrate that the parameter space for such WIMPs next door is sharply defined, bounded, and in large part potentially accessible. This parameter space, and the corresponding signals, depend on the leading interaction between the SM and the dark mediator; we establish it for both Higgs and vector portal interactions. In particular, there is a cosmological lower bound on the portal coupling strength necessary to thermalize the two sectors in the early universe. We determine this thermalization floor as a function of equilibration temperature for the first time. We demonstrate that direct detection experiments are currently probing this cosmological lower bound in some regions of parameter space, while indirect detection signals and terrestrial searches for the mediator cut further into the viable parameter space. We present regions of interest for both direct detection and dark mediator searches, including motivated parameter space for the direct detection of sub-GeV DM.

  19. Detecting Signage and Doors for Blind Navigation and Wayfinding.

    Science.gov (United States)

    Wang, Shuihua; Yang, Xiaodong; Tian, Yingli

    2013-07-01

    Signage plays a very important role to find destinations in applications of navigation and wayfinding. In this paper, we propose a novel framework to detect doors and signage to help blind people accessing unfamiliar indoor environments. In order to eliminate the interference information and improve the accuracy of signage detection, we first extract the attended areas by using a saliency map. Then the signage is detected in the attended areas by using a bipartite graph matching. The proposed method can handle multiple signage detection. Furthermore, in order to provide more information for blind users to access the area associated with the detected signage, we develop a robust method to detect doors based on a geometric door frame model which is independent to door appearances. Experimental results on our collected datasets of indoor signage and doors demonstrate the effectiveness and efficiency of our proposed method.

  20. The particle at the end of the universe the hunt for the Higgs and the discovery of a new world

    CERN Document Server

    Carroll, Sean

    2012-01-01

    It was the universes most elusive particle, the linchpin for everything scientists dreamed up to explain how stuff works. It had to be found. But projects as big as CERN's Large Hadron Collider don't happen without dealing and conniving, incredible risks and occasional skullduggery. Award-winning physicist and science popularizer Sean Carroll reveals the history-making forces of insight, rivalry, and wonder that fuelled the Higgs search and how its discovery opens a door into the mind-boggling domain of dark matter and other phenomena we never predicted. Told with unrivalled ambition, authority, and access to the teams, this is the greatest science story of our time - riveting and irresistible.

  1. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi

    2014-01-01

    to the antibody science in every project in antibody drug discovery. Recent experimental technologies allow for the rapid generation of large-scale data on antibody sequences, affinity, potency, structures, and biological functions; this should accelerate drug discovery research. Therefore, a robust bioinformatic...... infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...

  2. Blower door method in radon diagnostics

    International Nuclear Information System (INIS)

    Fronka, A.; Moucka, L.

    2004-01-01

    The idea of the radon transfer factor is commonly presented as the ratio of the building indoor radon concentration to the subsoil radon concentration. Ventilation and the pressure field over the whole building envelope, which varies in a time over a very wide range even in the same building, poses a major problem. Therefore a new approach based on the controlled conditions determining the soil air infiltration was developed. Radon in soil gas infiltrates into the building indoor environment particularly through cracks and other leakages in the structure providing the building contact with its subsoil. The infiltration is driven by the air pressure difference on the two sides of the structure. The pressure difference is caused by the stack effect and its value ranges from 1-2 Pa in family houses to some tens of Pa in higher buildings. Unfortunately, the pressure difference is very unstable under normal conditions, being affected by a host of parameters such as the height of the building, distribution and geometry of leakages, outdoor-indoor temperature difference, etc. Wind direction and velocity of the wind plays a major role. In our research the blower door method was applied in combination with a monitoring of the indoor radon concentration. The indoor-outdoor pressure difference and the pressure difference at the two sides of the screen shutter of the blower door fan are also measured. The blower door ensures a constant, evaluable air exchange rate. The fan power is regulated to provide a stable pressure difference within the range of roughly 5-100 Pa. This approach provides very well defined conditions allowing us to apply a constant ventilation-constant radon supply model. In such circumstances the dynamical changes of radon concentrations are very fast, and therefore a unique continual radon monitor was applied. The radon supply rate is evaluated from the radon steady state of the time course of radon concentration. The dependence of the radon supply rate on

  3. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  4. Ontwateren van zeugenmest door middel van omgekeerde osmose

    NARCIS (Netherlands)

    Thelosen, J.; Gastel, van J.; Cuyck, van J.

    1992-01-01

    In periodiek nummer 1 (februari 1991) is het proces van omgekeerde osmose reeds beschreven. In het kort komt omgekeerde osmose op het volgende neer: de te ontwateren vloeistof wordt onder hoge druk (55 bar) door filterbuizen gepompt.

  5. Deeltjesemissie door wegverkeer: emissiefactoren, deeltjesgrootteverdeling en chemische samenstelling

    NARCIS (Netherlands)

    Brink RMM van den; LAE

    1996-01-01

    In deze literatuurstudie werden zowel gegevens over uitlaatgas-deeltjesemissie alsook over deeltjesemissie als gevolg van slijtage van banden, remvoering en wegdek ge-inventariseerd. Daarnaast werd aandacht besteed aan deeltjesemissie als gevolg van, door rijdend verkeer, opgewerveld stof. Naast

  6. Rotational and frictional dynamics of the slamming of a door

    Science.gov (United States)

    Klein, Pascal; Müller, Andreas; Gröber, Sebastian; Molz, Alexander; Kuhn, Jochen

    2017-01-01

    A theoretical and experimental investigation of the rotational dynamics, including friction, of a slamming door is presented. Based on existing work regarding different damping models for rotational and oscillatory motions, we examine different forms for the (angular) velocity dependence (ωn, n = 0, 1, 2) of the frictional force. An analytic solution is given when all three friction terms are present and several solutions for specific cases known from the literature are reproduced. The motion of a door is investigated experimentally using a smartphone, and the data are compared with the theoretical results. A laboratory experiment under more controlled conditions is conducted to gain a deeper understanding of the movement of a slammed door. Our findings provide quantitative evidence that damping models involving quadratic air drag are most appropriate for the slamming of a door. Examining this everyday example of a physical phenomenon increases student motivation, because they can relate it to their own personal experience.

  7. Plattelandimpuls : leren door gewoon te dóen

    NARCIS (Netherlands)

    Noorduyn, L.

    2008-01-01

    Plattelandsondernemers die hun activiteiten verbreden, vergeten nogal eens serieuze aandacht te besteden aan de vermarkting van hun product. Met het project PlattelandImpuls hebben ondernemers hun vaardigheden op dat vlak kunnen verbeteren door te werken met product-marktcombinaties.

  8. An unexpected knock on Corrigan’s secret door

    Science.gov (United States)

    Woywodt, Alexander

    2010-01-01

    Corrigan’s secret door describes a metaphorical escape route for busy physicians. The term was derived from the successful and exceptionally busy professional life of Irish physician Dominic John Corrigan (1802–80). It is claimed that Corrigan’s outpatient clinic was so busy that he required a secret door in his consulting rooms to escape from the ever-growing queue of eager patients. The origins of this charming story are unknown, and the door may have never existed. However, at present, Corrigan’s secret door is often quoted when busy physicians have their own little ways in surviving a stressful professional life. Generations of British-trained doctors have grown up with Corrigan’s secret door, as it was featured in the introduction of the Oxford Handbook of Clinical Medicine. Accordingly, trainees as well as more senior doctors are often reminded that having a ‘secret door’ is vital in surviving in the medical profession. My own escape is through classical music and the violoncello, in particular. As the name implies, my own secret door is normally invisible to colleagues and patients. This little article is about a patient who found me out, and a reflection on the role of classical music and the cello in my professional life. PMID:25984078

  9. From acoustic descriptors to evoked quality of car door sounds.

    Science.gov (United States)

    Bezat, Marie-Céline; Kronland-Martinet, Richard; Roussarie, Vincent; Ystad, Sølvi

    2014-07-01

    This article describes the first part of a study aiming at adapting the mechanical car door construction to the drivers' expectancies in terms of perceived quality of cars deduced from car door sounds. A perceptual cartography of car door sounds is obtained from various listening tests aiming at revealing both ecological and analytical properties linked to evoked car quality. In the first test naive listeners performed absolute evaluations of five ecological properties (i.e., solidity, quality, weight, closure energy, and success of closure). Then experts in the area of automobile doors categorized the sounds according to organic constituents (lock, joints, door panel), in particular whether or not the lock mechanism could be perceived. Further, a sensory panel of naive listeners identified sensory descriptors such as classical descriptors or onomatopoeia that characterize the sounds, hereby providing an analytic description of the sounds. Finally, acoustic descriptors were calculated after decomposition of the signal into a lock and a closure component by the Empirical Mode Decomposition (EMD) method. A statistical relationship between the acoustic descriptors and the perceptual evaluations of the car door sounds could then be obtained through linear regression analysis.

  10. Blower-door techniques for measuring interzonal leakage

    Energy Technology Data Exchange (ETDEWEB)

    Hult, Erin L.; Sherman, Max H.; Walker, Iain

    2013-01-01

    Abstract The standard blower door test methods, such as ASTM E779, describe how to use a single blower door to determine the total leakage of a single-zone structure such as a detached single-family home. There are no standard test methods for measuring interzonal leakage in a two-zone or multi-zone building envelope such as might be encountered in with an attached garage or in a multifamily building. Some practitioners have been using techniques that involve making multiple measurements with a single blower door as well as combined measurements using multiple blower doors. Even for just two zones there are dozens of combinations of one-door and two-door test protocols that could conceivably be used to determine the interzonal air tightness. We examined many of these two-zone configurations using both simulation and measured data to estimate the accuracy and precision of each technique for realistic measurement scenarios. We also considered the impact of taking measurements at a single pressure versus over multiple pressures. We compared the various techniques and evaluated them for specific uses. Some techniques work better in one leakage regime; some are more sensitive to wind and other noise; some are more suited to determining only a subset of the leakage values. This paper makes recommendations on which techniques to use or not use for various cases and provides data that could be used to develop future test methods.

  11. Analysis of the quality of the whole journey (door-to-door) passenger expierence

    Energy Technology Data Exchange (ETDEWEB)

    Herrero Tomas, M.D.; Gonzalez Viosca, E.

    2016-07-01

    European cities increasingly face problems caused by transport and traffic. A key factor for all transport operators is the quality of the passenger experience as this particularly, affects the uptake of the service. A comprehensive study (METPEX FP7 EU project - www.metpex.eu) developed by a consortium of 16 European partners has analysed the quality of the whole journey (door-to-door) passenger experience, including private or individual forms transport and attending to specific need of users’ groups. For this purpose, a tool with a technological basis was used to collect data from 8 trial cities: Bucharest (Romania), Coventry (United Kingdom), Dublin (Ireland), Grevena (Greece), Rome (Italy), Stockholm (Sweden), Valencia (Spain) and Vilnius (Lithuania); and five FIA motorist networks countries. For a correct evaluation of quality experience, it was deployed a subset of key variables derived from the comprehensive set of potential satisfaction factors that were studied for each pilot city. In this paper, results of the travel experience are showed, including analysis of variables affecting behavior and feelings of passengers. (Author)

  12. 46 CFR 170.270 - Door design, operation, installation, and testing.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Door design, operation, installation, and testing. 170..., operation, installation, and testing. (a) Each Class 1 door must have a quick action closing device... the welding process so that the door frame is not distorted. (e) For each watertight door which is in...

  13. Global OpenSearch

    Science.gov (United States)

    Newman, D. J.; Mitchell, A. E.

    2015-12-01

    At AGU 2014, NASA EOSDIS demonstrated a case-study of an OpenSearch framework for Earth science data discovery. That framework leverages the IDN and CWIC OpenSearch API implementations to provide seamless discovery of data through the 'two-step' discovery process as outlined by the Federation for Earth Sciences (ESIP) OpenSearch Best Practices. But how would an Earth Scientist leverage this framework and what are the benefits? Using a client that understands the OpenSearch specification and, for further clarity, the various best practices and extensions, a scientist can discovery a plethora of data not normally accessible either by traditional methods (NASA Earth Data Search, Reverb, etc) or direct methods (going to the source of the data) We will demonstrate, via the CWICSmart web client, how an earth scientist can access regional data on a regional phenomena in a uniform and aggregated manner. We will demonstrate how an earth scientist can 'globalize' their discovery. You want to find local data on 'sea surface temperature of the Indian Ocean'? We can help you with that. 'European meteorological data'? Yes. 'Brazilian rainforest satellite imagery'? That too. CWIC allows you to get earth science data in a uniform fashion from a large number of disparate, world-wide agencies. This is what we mean by Global OpenSearch.

  14. Components for containment enclosures - Part 3: Transfer systems such as plain doors, airlock chambers, double door transfer systems, leaktight connections for waste drums. 1. ed.

    International Nuclear Information System (INIS)

    1998-01-01

    This part of ISO 11933 specifies requirements for the selection, construction and use of the following leak tight components: doors, airlock chambers, double door transfer systems, leaktight connections for waste drums. Some of the elements, double doors or airlock chambers are described in ISO 11933-1 and ISO 11933-2 as well. Doors having bigger dimensions used for personnel od larger objects are not covered by this document

  15. Protoparvovirus Knocking at the Nuclear Door.

    Science.gov (United States)

    Mäntylä, Elina; Kann, Michael; Vihinen-Ranta, Maija

    2017-10-02

    Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome. In recent years, our understanding of the multistep process of the capsid nuclear import has improved, and led to the discovery of unique viral nuclear entry strategies. Preceded by endosomal transport, endosomal escape and microtubule-mediated movement to the vicinity of the nuclear envelope, the protoparvoviruses interact with the nuclear pore complexes. The capsids are transported actively across the nuclear pore complexes using nuclear import receptors. The nuclear import is sometimes accompanied by structural changes in the nuclear envelope, and is completed by intranuclear disassembly of capsids and chromatinization of the viral genome. This review discusses the nuclear import strategies of protoparvoviruses and describes its dynamics comprising active and passive movement, and directed and diffusive motion of capsids in the molecularly crowded environment of the cell.

  16. SAFETY BULLETIN TIS 2002-03 GLASS DOORS

    CERN Multimedia

    2002-01-01

    Be careful! What happened?   Unsignaled reinforced glass.   Signaled safety glass.   A visitor recently hurt his leg when he walked into a glass door which shattered from the impact. This door was made of reinforced glass, a material which is inappropriate for this kind of use as it is too fragile. Indeed, it shatters into sharp splinters which can cause serious injury. Furthermore, the door was not easily visible (badly lit, no warning signs, ...). Corrective measures Just after the accident: glass doors were signed to make them more visible; replacement of dangerous glass panes planned for 2003. What preventive measures can be taken against this kind of accident? If you are in charge of projects and works: In the call for tender, specify the acceptable shock resistance level of the glass pane; Before the door is mounted, insist on receiving technical documentation and/or certificate of conformity from the supplier; If in doubt, ask advice from the TIS/GS sa...

  17. Understanding "revolving door" patients in general practice: a qualitative study.

    Science.gov (United States)

    Williamson, Andrea E; Mullen, Kenneth; Wilson, Philip

    2014-02-13

    'Revolving door' patients in general practice are repeatedly removed from general practitioners' (GP) lists. This paper reports a qualitative portion of the first mixed methods study of these marginalised patients. We conducted qualitative semi-structured interviews with six practitioner services staff and six GPs in Scotland, utilizing Charmazian grounded theory to characterise 'revolving door' patients and their impact from professionals' perspectives. 'Revolving door' patients were reported as having three necessary characteristics; they had unreasonable expectations, exhibited inappropriate behaviours and had unmet health needs. A range of boundary breaches were reported too when 'revolving door' patients interacted with NHS staff. We utilise the 'sensitising concepts' of legitimacy by drawing on literature about 'good and bad' patients and 'dirty work designations.' We relate these to the core work of general practice and explore the role that medical and moral schemas have in how health service professionals understand and work with 'revolving door' patients. We suggest this may have wider relevance for the problem doctor patient relationship literature.

  18. Improving Door-to-balloon Time by Decreasing Door-to-ECG time for Walk-in STEMI Patients

    Directory of Open Access Journals (Sweden)

    Coyne, Christopher J.

    2014-12-01

    Full Text Available Introduction: The American Heart Association/American College of Cardiology guidelines recommend rapid door-to-electrocardiography (ECG times for patients with ST-segment elevation myocardial infarction (STEMI. Previous quality improvement research at our institution revealed that we were not meeting this benchmark for walk-in STEMI patients. The objective is to investigate whether simple, directed changes in the emergency department (ED triage process for potential cardiac patients could decrease door-to-ECG times and secondarily door-to-balloon times. Methods: We conducted an interventional study at a large, urban, public teaching hospital from April 2010 to June 2012. All patients who walked into the ED with a confirmed STEMI were enrolled in the study. The primary intervention involved creating a chief complaint-based “cardiac triage” designation that streamlined the evaluation of potential cardiac patients. A secondary intervention involved moving our ECG technician and ECG station to our initial triage area. The primary outcome measure was door-to-ECG time and the secondary outcome measure was door-to-balloon time. Results: We enrolled 91 walk-in STEMI patients prior to the intervention period and 141 patients after the invention. We observed statistically significant reductions in door-to-ECG time (43±93 to 30±72 minutes, median 23 to 14 minutes p<0.01, ECG-to-activation time (87±134 to 52±82 minutes, median 43 to 31 minutes p<0.01, and door-to-balloon time (134±146 to 84±40 minutes, median 85 -75 minutes p=0.03. Conclusion: By creating a chief complaint-based cardiac triage protocol and by streamlining ECG completion, walk-in STEMI patients are systematically processed through the ED. This is not only associated with a decrease in door-to-balloon time, but also a decrease in the variability of the time sensitive intervals of door-to-ECG and ECG-to-balloon time. [West J Emerg Med. 2015;16(1:184–189.

  19. F-door spaces and F-submaximal spaces

    Directory of Open Access Journals (Sweden)

    Lobna Dridi

    2013-04-01

    Full Text Available Submaximal spaces and door spaces play an enigmatic role in topology. In this paper, reinforcing this role, we are concerned with reaching two main goals: The first one is to characterize topological spaces X such that F(X is a submaximal space (resp., door space for some covariant functor Ff rom the category Top to itself. T0, and FH functors are completely studied. Secondly, our interest is directed towards the characterization of maps f given by a flow (X, f in the category Set, such that (X,P(f is submaximal (resp., door where P(f is a topology on X whose closed sets are exactly the f-invariant sets.

  20. Confounding adjustment through front-door blocking in longitudinal studies

    Directory of Open Access Journals (Sweden)

    Arvid Sjölander

    2013-03-01

    Full Text Available A common aim of epidemiological research is to estimate the causal effect of a particular exposure on a particular outcome. Towards this end, observed associations are often ‘adjusted’ for potential confounding variables. When the potential confounders are unmeasured, explicit adjustment becomes unfeasible. It has been demonstrated that causal effects can be estimated even in the presence of umeasured confounding, utilizing a method called ‘front-door blocking’. In this paper we generalize this method to longitudinal studies. We demonstrate that the method of front-door blocking poses a number of challenging statistical problems, analogous to the famous problems associ- ated with the method of ‘back-door blocking’.

  1. Dynamic Object Oriented Requirements System (DOORS) System Test Plan

    International Nuclear Information System (INIS)

    JOHNSON, A.L.

    2000-01-01

    The U. S. Department of Energy, Office of River Protection (ORP) will use the Dynamic Object Oriented Requirements System (DOORS) as a tool to assist in identifying, capturing, and maintaining the necessary and sufficient set of requirements for accomplishing the ORP mission. By managing requirements as one integrated set, the ORP will be able to carry out its mission more efficiently and effectively. DOORS is a Commercial-Off-The-Shelf (COTS) requirements management tool. The tool has not been customized for the use of the PIO, at this time

  2. SPOT: the door to digital innovation

    International Nuclear Information System (INIS)

    Anon.

    2017-01-01

    AREVA NP has opened in Lyon a small department, named SPOT, whose aim is to develop innovative digital technologies such as CAVE and MODOP'3D. CAVE, that is the acronym of Cave Automatic Virtual Environment, is a large screen that splits the room in half and shows the virtual copy of the Astrid reactor. Viewers can wander inside the reactor and its building through the screen and sees all the details of the design. CAVE represents a complete virtual 3-dimension prototype of the Astrid reactor whose aim is to help assessing any change in the design. MODOP'3D is a virtual maintenance tool that allows the operator to simulate reactor maintenance operations in a 3-dimensional way in order to assess their feasibility and optimize them. Exoskeletons whose purpose is to help operators to handle heavy loads are also tested at SPOT. (A.C.)

  3. Genetic engineering. Rifkin's foot in the door.

    Science.gov (United States)

    Budiansky, S

    The U.S. Court of Appeals is considering a motion by the National Institutes of Health and the University of California, Berkeley, to lift a lower court ban on field trials of recombinant DNA organisms. Last spring, a U.S. District Court judge granted activist Jeremy Rifkin's request for an injunction and blocked NIH from approving any field trials of recombinant organisms without first furnishing an environmental impact statement. If the court requires NIH's Recombinant DNA Advisory Committee (RAC) to furnish an individual impact statement before each trial, Rifkin will have established that RAC's review procedures are subject to the National Environmental Policy Act, and possibly will have opened the way for routine court challenges of every RAC-approved field test.

  4. The effect of screening doors and windows on indoor density of Anopheles arabiensis in south-west Ethiopia: a randomized trial.

    Science.gov (United States)

    Massebo, Fekadu; Lindtjørn, Bernt

    2013-09-12

    Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings.

  5. Bear at the back door | Prinsloo | Scientia Militaria: South African ...

    African Journals Online (AJOL)

    Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 3 (1979) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Bear at the back door. C Prinsloo ...

  6. Polychaete Anneliden verzameld door Het Rijksinstituut voor Biologisch Visscherijonderzoek

    NARCIS (Netherlands)

    Horst, R.

    1920-01-01

    Lepidonotus squamatus L. juv. Waarn. 134. Enkhuizerzand. 7 Febr. 1909. Zooals vroeger door mij aangetoond, is deze soort vrij gemeen in de Zuiderzee. Eunoa nodosa M. Sars. Waarn. 16. 55° 40' N.Br., 0° 50' W.L. 8 Maart 1914. Harmothoë (Evarne) impar (Johnst.). Waarn. 69. Molengat. 16 Oct. 1913. De

  7. Barcode van DNA. Democratisering van de taxonomie door digitaal identificatiesysteem

    NARCIS (Netherlands)

    Bakker, F.T.

    2011-01-01

    Het herkennen van biologische soorten aan de hand van een gestandaardiseerde DNA-barcode heeft de laatste tijd een enorme vlucht genomen. Gedreven door aan de ene kant de biodiversiteitscrises en de mogelijke global change, en aan de andere kant zowel razendsnelle technologische vooruitgang als ook

  8. Plantenkaartjes uitgegeven door het I.V.O.N

    NARCIS (Netherlands)

    NN,

    1959-01-01

    De serie door het I.V.O.N. gepubliceerde verspreidingskaartjes van Nederlandse plantensoorten is wederom verkrijgbaar. De prijzen zijn als volgt: afl. 1, 1935, 21 kaartjes van diverse soorten f. 1.35 afl. 2, 1936, 32 kaartjes van diverse soorten „ 2.00 afl. 3, 1936, 18 kaartjes van Potamogeton „

  9. Inclusie door interprofessionele samenwerking. : Resultaten van de proeftuinen van PACT.

    NARCIS (Netherlands)

    Doornenbal, Jeannette; Fukkink, Ruben; van Yperen, Tom; Balledux, Mariëlle; Spoelstra, Jolanda; Verseveld, Marloes

    2017-01-01

    Deze rapportage gaat over de resultaten van de PACT-proeftuinen waaraan in opdracht van Het Kinderopvangfonds van 2015 tot 2017 is gewerkt. PACT-proeftuinen zijn innovatieve praktijken waarin door middel van interprofessionele samenwerking tussen de kinderopvang, het basisonderwijs en de zorg wordt

  10. Door de ogen van de ander kijken: kunst als veranderkracht

    NARCIS (Netherlands)

    Smilde, Rineke

    2015-01-01

    Presentie gehouden bij een besloten expert meeting van de KNAW en de Boekmanstichting in Amsterdam. Door de ogen van de ander kijken: kunst als veranderkracht. Ik maak graag van de gelegenheid gebruik om iets te vertellen vanuit mijn werk als lector aan het PCC van de Hanzehogeschool Groningen.

  11. DE VERWOESTINGEN VAN BABYLON DOOR DARIUS I EN ...

    African Journals Online (AJOL)

    Test

    Het is alles behalve gemakkelijk deze bedreigingen in hun historisch verband te rangschikken. Bij een profetie als Jes. 21: „Gevallen, gevallen is Babel en al haar afgodsbeelden heeft. Hij ter aarde verbrijzeld”—zou men nog aan de eerste berichten kunnen denken, die Jeruzalem omtrent de verwoesting van Babylon door ...

  12. Portal: Your Door to World Languages and Cultures

    Science.gov (United States)

    Elliott, Don; Lawton, Rachele

    2009-01-01

    Portal: Your Door to World Languages and Cultures was a series of public cultural events, in a variety of formats, created through a new partnership between the credit and continuing education (noncredit) foreign language programs at the Community College of Baltimore County (CCBC). Portal was designed to cultivate interest in foreign languages…

  13. A Knock at the Door. The Oryx Multicultural Folktale Series.

    Science.gov (United States)

    Shannon, George, Comp.

    This folktales collection includes 35 versions, representing countries and cultures from around the world, of the traditional tale in which a dangerous character knocks at the door and tries to trick the children into letting him inside. The stories are intended for use in homes, schools, and libraries by both children and adults who enjoy sharing…

  14. DOORS English--The Cognitive Basis of Rhetorical Models.

    Science.gov (United States)

    Taylor, Karl K.

    1979-01-01

    The Development of Operational Reasoning Skills (DOORS) program at Illinois Central College is an interdisciplinary experiment that guides students from concrete to formal operational levels of thought to ensure that they understand the concepts and cognitive skills undergirding the rhetorical modes. (RL)

  15. Usability of Discovery Portals

    OpenAIRE

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals are not spatial data experts but professionals with limited spatial knowledge, and a focus outside the spatial domain. An exploratory usability experiment was carried out in which three discovery p...

  16. A Study on the Modeling of the Oil Damper in an Auto-Door Hinge

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Kwang Soon; Kim, Jong Tae; Kim, Hwan Yeol

    2009-11-15

    An auto-door hinge, which is one of the automatic door-closing apparatuses, has been widely used to prevent fire propagations in living or commercial buildings. The auto-door hinge consists of a spring to accumulate power for closing a door and an oil damper to control door-closing velocity. To predict and optimize the temporal door behavior during the door-closing period, the auto-door closing system was modeled as a second order-damping system. And a damping coefficient of the oil damper was also theoretically modeled by analyzing Newtonian, incompressible, viscous flow through an oil passage between a oil control rod and a oil piston body. The temporal door behaviors during the door-closing period were predicted with respect to the gap distance of the oil passage, oil viscosity, and pre-compressing of the spring. Temporal door behavior measurement method using an encoder system was also developed to validate the modelling on the oil damping system. As using the developed test apparatus, the temporal door position, velocity, and rotational torque were measured, and the modelling method was evaluated.

  17. A Study on the Modeling of the Oil Damper in an Auto-Door Hinge

    International Nuclear Information System (INIS)

    Ha, Kwang Soon; Kim, Jong Tae; Kim, Hwan Yeol

    2009-11-01

    An auto-door hinge, which is one of the automatic door-closing apparatuses, has been widely used to prevent fire propagations in living or commercial buildings. The auto-door hinge consists of a spring to accumulate power for closing a door and an oil damper to control door-closing velocity. To predict and optimize the temporal door behavior during the door-closing period, the auto-door closing system was modeled as a second order-damping system. And a damping coefficient of the oil damper was also theoretically modeled by analyzing Newtonian, incompressible, viscous flow through an oil passage between a oil control rod and a oil piston body. The temporal door behaviors during the door-closing period were predicted with respect to the gap distance of the oil passage, oil viscosity, and pre-compressing of the spring. Temporal door behavior measurement method using an encoder system was also developed to validate the modelling on the oil damping system. As using the developed test apparatus, the temporal door position, velocity, and rotational torque were measured, and the modelling method was evaluated

  18. 16 CFR 1211.13 - Inherent force activated secondary door sensors.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Inherent force activated secondary door sensors. 1211.13 Section 1211.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT... across the door so that the axis is perpendicular to the plane of the door. See Figure 6 of this part...

  19. Door locking and exit security measures on acute psychiatric admission wards

    NARCIS (Netherlands)

    Nijman, H.L.I.; Bowers, L.; Haglund, K.; Muir-Cochrane, E.; Simpson, A.; Merwe, M. van der

    2011-01-01

    Locking the exit doors of psychiatric wards is believed to reduce the risk of patients absconding. The aims of the study were to investigate both the prevalence of door locking and other exit security measures on UK admission wards, as well as whether door locking appears to be effective in keeping

  20. Usability of Discovery Portals

    NARCIS (Netherlands)

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals

  1. Discovery and the atom

    International Nuclear Information System (INIS)

    1989-01-01

    ''Discovery and the Atom'' tells the story of the founding of nuclear physics. This programme looks at nuclear physics up to the discovery of the neutron in 1932. Animation explains the science of the classic experiments, such as the scattering of alpha particles by Rutherford and the discovery of the nucleus. Archive film shows the people: Lord Rutherford, James Chadwick, Marie Curie. (author)

  2. A quantum causal discovery algorithm

    Science.gov (United States)

    Giarmatzi, Christina; Costa, Fabio

    2018-03-01

    Finding a causal model for a set of classical variables is now a well-established task—but what about the quantum equivalent? Even the notion of a quantum causal model is controversial. Here, we present a causal discovery algorithm for quantum systems. The input to the algorithm is a process matrix describing correlations between quantum events. Its output consists of different levels of information about the underlying causal model. Our algorithm determines whether the process is causally ordered by grouping the events into causally ordered non-signaling sets. It detects if all relevant common causes are included in the process, which we label Markovian, or alternatively if some causal relations are mediated through some external memory. For a Markovian process, it outputs a causal model, namely the causal relations and the corresponding mechanisms, represented as quantum states and channels. Our algorithm opens the route to more general quantum causal discovery methods.

  3. The Cook and the Writer: Maryse Condé's Journey of Self-Discovery

    Directory of Open Access Journals (Sweden)

    Bonnie Thomas

    2013-07-01

    Full Text Available In her 2006 memoir, Victoire, les saveurs et les mots, (translated into English as Victoire: My Mother’s Mother, celebrated Guadeloupean writer Maryse Condé makes an explicit comparison between herself and her maternal grandmother Victoire. A work of literary invention as much as of personal reflection, this book represents an example of Condé’s quest to know herself as a woman and a writer. It also enables her to fill in some of the gaps left by her mother Jeanne who was always reluctant to share details of her childhood with her daughter and died when Condé was only twenty. One of the few facts Jeanne gives to her about Victoire is that she was a cook and that the results of her labour helped open the doors to greater autonomy for her daughter and, consequently, her granddaughter. This paper will examine the way in which food and cooking are linked to Condé’s journey of self-discovery as well as to the historical trajectory of the French Caribbean islands of Marie-Galante and Guadeloupe.

  4. Topology Discovery Using Cisco Discovery Protocol

    OpenAIRE

    Rodriguez, Sergio R.

    2009-01-01

    In this paper we address the problem of discovering network topology in proprietary networks. Namely, we investigate topology discovery in Cisco-based networks. Cisco devices run Cisco Discovery Protocol (CDP) which holds information about these devices. We first compare properties of topologies that can be obtained from networks deploying CDP versus Spanning Tree Protocol (STP) and Management Information Base (MIB) Forwarding Database (FDB). Then we describe a method of discovering topology ...

  5. Intelligent Vision System for Door Sensing Mobile Robot

    Directory of Open Access Journals (Sweden)

    Jharna Majumdar

    2012-08-01

    Full Text Available Wheeled Mobile Robots find numerous applications in the Indoor man made structured environments. In order to operate effectively, the robots must be capable of sensing its surroundings. Computer Vision is one of the prime research areas directed towards achieving these sensing capabilities. In this paper, we present a Door Sensing Mobile Robot capable of navigating in the indoor environment. A robust and inexpensive approach for recognition and classification of the door, based on monocular vision system helps the mobile robot in decision making. To prove the efficacy of the algorithm we have designed and developed a ‘Differentially’ Driven Mobile Robot. A wall following behavior using Ultra Sonic range sensors is employed by the mobile robot for navigation in the corridors.  Field Programmable Gate Arrays (FPGA have been used for the implementation of PD Controller for wall following and PID Controller to control the speed of the Geared DC Motor.

  6. Ervaringen van schaamte en psychologisch lijden door voedselbankklanten

    Directory of Open Access Journals (Sweden)

    Hille Hoogland

    2016-03-01

    men and 27 women. The interviews were transcribed verbatim and analysed in Atlas.ti by two researchers, using attribute and structural coding.Our results show that foodbank clients use a combination of different strategies to cope with living on tight budgets. Most of them save money on food, non-food and social activities. Another strategy is to ask for support from family or friends for money, clothing or food. Some respondents are almost completely dependent on gifts from friends and the food parcel and some also reported being restricted in their social life and having lost friends. We found that lack of money is related to psychological suffering: sleeplessness, stress, fear, panic, depression and feelings of sadness. The causes mentioned for this suffering were: debts, persistent letters from creditors, and not being able to afford consumer goods and/or activities. Some respondents reported seeking to numb these feelings through the use of alcohol or cannabis. Others avoided opening letters or answering telephone calls.In the interviews, foodbank clients expressed their feelings about their situation. Shame was the most frequently mentioned emotion and related to the label of “foodbank client”, the working method of the foodbank or not being able to consume what they wanted to. Firstly, respondents felt ashamed about being a foodbank client, because this is not acceptable in their social and cultural environment, and there is a negative stigma associated with being a foodbank client rather than a “normal working citizen”. Some of the respondents try to hide the fact that they use a foodbank, while others stated that they liked to form friendships with other foodbank clients because they would be more likely to accept and understand them. Another reaction was to downplay the situation. Secondly, shame was connected to the way that the foodbank operates. Clients feel ashamed to have to show their administration in the assessment interview before they can

  7. Open3DGRID

    DEFF Research Database (Denmark)

    Tosco, Paolo; Balle, Thomas

    2011-01-01

    MFA/CoMSIA fields (exported from SYBYL with the aid of a small SPL script). High computational performance is attained through implementation of parallelized algorithms for MIF generation. Most prominent features in Open3DGRID include: •Seamless integration with OpenBabel, PyMOL, GAUSSIAN, FIREFLY, GAMESS...... visualization of results in PyMOL, MOE, Maestro and SYBYL •User-friendly interface to all major QM packages (e.g. GAUSSIAN, FIREFLY, GAMESS-US, TURBOMOLE, MOLDEN), allows calculation of QM electron density and electrostatic potential 3D maps from within Open3DGRID •User-friendly interface to Molecular Discovery...

  8. Flow of pedestrians through narrow doors with different competitiveness

    International Nuclear Information System (INIS)

    Garcimartín, A; Pastor, J M; Zuriguel, I; Parisi, D R; Martín-Gómez, C

    2016-01-01

    We report a thorough analysis of the intermittent flow of pedestrians through a narrow door. The observations include five different sets of evacuation drills with which we have investigated the effect of door size and competitiveness on the flow dynamics. Although the outcomes are in general compatible with the existence of the faster-is-slower effect, the temporal evolution of the instantaneous flow rate provides evidence of new features. These stress the crucial role of the number of people performing the tests, which has an influence on the obtained results. Once the transients at the beginning and end of the evacuation are removed, we have found that the time lapses between the passage of two consecutive pedestrians display heavy-tailed distributions in all the scenarios studied. Meanwhile, the distribution of burst sizes decays exponentially; this can be linked to a constant probability of finding a long-lasting clog during the evacuation process. Based on these results, a discussion is presented on the caution that should be exercised when measuring or describing the intermittent flow of pedestrians through narrow doors. (paper: interdisciplinary statistical mechanics)

  9. The self-organizing fractal theory as a universal discovery method: the phenomenon of life

    Directory of Open Access Journals (Sweden)

    Kurakin Alexei

    2011-03-01

    is an organizational state/phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter. The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.

  10. The self-organizing fractal theory as a universal discovery method: the phenomenon of life.

    Science.gov (United States)

    Kurakin, Alexei

    2011-03-29

    /phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter.The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.

  11. New discoveries on the ecology and echolocation of the heart ...

    African Journals Online (AJOL)

    New discoveries on the ecology and echolocation of the heart-nosed bat Cardioderma cor with a ... Open Access DOWNLOAD FULL TEXT ... However, additional genetic data are necessary to resolve the phylogeny of Megadermatidae, ...

  12. Discovery and Innovation - Vol 11, No 3 (1999)

    African Journals Online (AJOL)

    Discovery and Innovation. ... Open Access DOWNLOAD FULL TEXT ... Product Yields and Kinetic Studies of Methylcyclopentane Reforming on Undried Pt – Re/ ... Rare Earth Metal Analysis Using Direct Excitation with 241 Americium Source.

  13. Specificity of discoveries in radiochemistry

    International Nuclear Information System (INIS)

    Krivomazov, A.N.

    1977-01-01

    The development of radiochemistry as a science is elucidated. On the basis of original papers and archives materials which have become available only recently, specific features of opening the law of radioactive displacements and isotopy of radioactive elements are presented in detail. A contribution of Hevesy, Russel, Fajans, and Soddy into the solution of this problem is considered; an important role of Rutherford in putting down the priority conflict is shown. Two stages of scientific generalization are singled out in the history of opening the law of radioactive displacements: the stage of the rules and the stage of the laws. On this basis the solutions of the priority problems have been reconsidered. It is shown that the history of radiochemistry is rich in discoveries which have undergone a relatively long evolution

  14. Service Discovery At Home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent

  15. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...

  16. Decades of Discovery

    Science.gov (United States)

    2011-06-01

    For the past two-and-a-half decades, the Office of Science at the U.S. Department of Energy has been at the forefront of scientific discovery. Over 100 important discoveries supported by the Office of Science are represented in this document.

  17. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several

  18. Double seal door design and analysis for ITER transfer cask

    International Nuclear Information System (INIS)

    Liu, C.L.; Yao, D.M.; Cheng, T.

    2007-01-01

    DSD (Double seal door) design concept was introduced. 3-D model work was performed for DSD in the three typical regions, such as upper port, equatorial port, divertor port. The numerical analysis for some typical components was done based on Finite Element (FE) method by using ANSYS code, especially for the optimization activities. The rescue procedures of the DSD was discussed which could benefit a little for future engineering implementation. The design and analysis work can support and be the important reference for future procurement. (authors)

  19. Container lid gasket protective strip for double door transfer system

    Science.gov (United States)

    Allen, Jr., Burgess M

    2013-02-19

    An apparatus and a process for forming a protective barrier seal along a "ring of concern" of a transfer container used with double door systems is provided. A protective substrate is supplied between a "ring of concern" and a safety cover in which an adhesive layer of the substrate engages the "ring of concern". A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the "ring of concern" and the adhesive layer of the substrate.

  20. "Eureka, Eureka!" Discoveries in Science

    Science.gov (United States)

    Agarwal, Pankaj

    2011-01-01

    Accidental discoveries have been of significant value in the progress of science. Although accidental discoveries are more common in pharmacology and chemistry, other branches of science have also benefited from such discoveries. While most discoveries are the result of persistent research, famous accidental discoveries provide a fascinating…

  1. Identification of persons entering through the door from the accelerometers data

    OpenAIRE

    Vodopivec, Tadej

    2013-01-01

    This thesis presents a system for automatic identification of a person who walks through a door based on the information gathered with acceleration sensors, which are mounted on the door. The proccedure for automatic identification consists of four steps. In the first step, data acquisition and coordinate system rotation is performed. Coordinate system rotation is needed in order to match the direction of measured accelerations with the direction of components of the forces acting on the door...

  2. Social Media: Opening New Doors for the Domestic Tourism Industry in Albania

    OpenAIRE

    Vjollca Hysi; Klodiana Gorica; Sokol Luzi

    2015-01-01

    The online word is becoming every day more and more important for the tourism industry. Through different technologies, it has made the possibility to ease the way people search and decide for their own travel destination, the way they pick their accommodation and their traveling medium. In particular the online social media, as part of the online word, has created new opportunities for interaction and communication between people. Today individuals have the opportunity to share ...

  3. PM₂.₅ opened a door to public participation addressing environmental challenges in China.

    Science.gov (United States)

    Huang, Ganlin

    2015-02-01

    China has long been regarded as a centralized society where the public has little influence on decision-making. Such a top-down management scheme is perceived as a major obstacle to address complicated environment issues. The recent public campaign in China to urge creation of a nationwide PM₂.₅ monitoring network and mitigation plan provides an unprecedented case of how the public participated and influenced policy-making in a centralized society. This paper reviews key incidents in the campaign chronologically. Here we identify information technology, public awareness of air quality's health impacts and the fact air quality affects everyone as public goods as the major factors promoting public participation. This case demonstrates that public participation can happen in a centralized, top-down society such as China. Continued environmental deterioration may stimulate similar campaigns for other issues. We anticipate this essay to be a starting point for more studies on how environmental issues stimulate incremental social change by making people involved in decision-making process, especially in societies where they are rarely able to do so. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Secure Borders and Open Doors: Preserving Our Welcome to the World in an Age of Terrorism

    Science.gov (United States)

    2008-01-01

    81 In October 2007, the Walt Disney Company presented State and DHS with a “Welcome to America” video now being displayed at CA posts and Model...airports council international-north america, Co-Chair, Ports of Entry Working Group James (Jay) Rasulo, chairman, walt disney parks and resorts...SBodac members and additional subject matter experts who were consulted. among the many who provided such assistance were: Bill Bailey, walt disney

  5. NGVS. Challenges for the Japanese gas industry to open the door for their mass introduction

    International Nuclear Information System (INIS)

    Akimoto, Minoru; Kawamoto, Hiroshi; Suzuki, Tatsuya; Yamaguchi, Eiji

    1997-01-01

    There have been a number of restraints in Japan delaying the introduction of natural gas vehicles (NGVs), which is a new comer in car industry. The Japanese gas industry, with support from government agencies, has conducted feasibility studies and clarified necessary technical and safety standards and regulations. These efforts have contributed to the government's drive for deregulation. Concurrently, the gas industry worked out its own scenarios for the promotion of NGVs in Japan, which helped the government in laying down necessary regulations and establishing clear market objectives for the vehicles as government policies. Such activities have yielded model introduction by the national and local governments and government-sponsored incentives for NGV promotion. For auto manufacturers, the gas industry proposed joint development projects and clarified potential market for NGVs. Consequently, many manufactures are now involved in their own NGV development projects. (au)

  6. Art and science in health care research: pushing at open doors or locked in institutions?

    Science.gov (United States)

    Freshwater, Dawn; Cahill, Jane; Walsh, Elizabeth; Muncey, Tessa; Esterhuizen, Philip

    2012-09-01

    Research methods are usually dictated and driven by the research question. In the context of research in "closed" systems--for example, offender health settings--it is imperative that the research question takes into consideration the context in which the research is located. Conducting research that has action, transformation, and creativity at its heart is a significant challenge in closed cultures, for both the researcher and the researched. Using two exemplars, we question whether researchers should adopt a safe approach to researching these closed cultures and to what extent they should engage in methodological tensions and ethical dilemmas that provoke and support reflection on change. By reflecting on our previous research studies, we aim not so much to provide a definitive answer to this question but to suggest that researchers give careful consideration to the methods appropriate to both the context of the research and its purpose.

  7. Video Conferencing for Opening Classroom Doors in Initial Teacher Education: Sociocultural Processes of Mimicking and Improvisation

    Directory of Open Access Journals (Sweden)

    Rolf Wiesemes

    2010-11-01

    Full Text Available In this article, we present an alternative framework for conceptualising video-conferencing uses in initial teacher education and in Higher Education (HE more generally. This alternative framework takes into account the existing models in the field, but – based on a set of interviews conducted with teacher trainees and wider analysis of the related literature – we suggest that there is a need to add to existing models the notions of ‘mimicking’ (copying practice and improvisation (unplanned and spontaneous personal learning moments. These two notions are considered to be vital, as they remain valid throughout teachers’ careers and constitute key affordances of video-conferencing uses in HE. In particular, we argue that improvisational processes can be considered as key for developing professional practice and lifelong learning and that video-conferencing uses in initial teacher education can contribute to an understanding of training and learning processes. Current conceptualisations of video conferencing as suggested by Coyle (2004 and Marsh et al. (2009 remain valid, but also are limited in their scope with respect to focusing predominantly on pragmatic and instrumental teacher-training issues. Our article suggests that the theoretical conceptualisations of video conferencing should be expanded to include elements of mimicking and ultimately improvisation. This allows us to consider not just etic aspects of practice, but equally emic practices and related personal professional development. We locate these arguments more widely in a sociocultural-theory framework, as it enables us to describe interactions in dialectical rather than dichotomous terms (Lantolf & Poehner, 2008.

  8. The U.S. Rebalance and Europe: Convergent Strategies Open Doors to Improved Cooperation

    Science.gov (United States)

    2014-06-01

    Rota- tional Force in Darwin , Australia, and forward-basing of Littoral Combat Ships in Singapore—risk sending the wrong signal to China and U.S...On occasion they have been controversial trail- 7 The U.S. “Rebalance” and Europe blazers in that regard—for example, when President Charles de...carrier Charles de Gaulle and Indian naval units.17 9 The U.S. “Rebalance” and Europe The French are active in other parts of Asia as well. Paris maintains

  9. Training adaptation and heart rate variability in elite endurance athletes: opening the door to effective monitoring.

    Science.gov (United States)

    Plews, Daniel J; Laursen, Paul B; Stanley, Jamie; Kilding, Andrew E; Buchheit, Martin

    2013-09-01

    The measurement of heart rate variability (HRV) is often considered a convenient non-invasive assessment tool for monitoring individual adaptation to training. Decreases and increases in vagal-derived indices of HRV have been suggested to indicate negative and positive adaptations, respectively, to endurance training regimens. However, much of the research in this area has involved recreational and well-trained athletes, with the small number of studies conducted in elite athletes revealing equivocal outcomes. For example, in elite athletes, studies have revealed both increases and decreases in HRV to be associated with negative adaptation. Additionally, signs of positive adaptation, such as increases in cardiorespiratory fitness, have been observed with atypical concomitant decreases in HRV. As such, practical ways by which HRV can be used to monitor training status in elites are yet to be established. This article addresses the current literature that has assessed changes in HRV in response to training loads and the likely positive and negative adaptations shown. We reveal limitations with respect to how the measurement of HRV has been interpreted to assess positive and negative adaptation to endurance training regimens and subsequent physical performance. We offer solutions to some of the methodological issues associated with using HRV as a day-to-day monitoring tool. These include the use of appropriate averaging techniques, and the use of specific HRV indices to overcome the issue of HRV saturation in elite athletes (i.e., reductions in HRV despite decreases in resting heart rate). Finally, we provide examples in Olympic and World Champion athletes showing how these indices can be practically applied to assess training status and readiness to perform in the period leading up to a pinnacle event. The paper reveals how longitudinal HRV monitoring in elites is required to understand their unique individual HRV fingerprint. For the first time, we demonstrate how increases and decreases in HRV relate to changes in fitness and freshness, respectively, in elite athletes.

  10. Cell Culture in Microgravity: Opening the Door to Space Cell Biology

    Science.gov (United States)

    Pellis, Neal R.; Dawson, David L. (Technical Monitor)

    1999-01-01

    Adaptational response of human cell populations to microgravity is investigated using simulation, short-term Shuttle experiments, and long-term microgravity. Simulation consists of a clinostatically-rotated cell culture system. The system is a horizontally-rotated cylinder completely filled with culture medium. Low speed rotation results in continuous-fall of the cells through the fluid medium. In this setting, cells: 1) aggregate, 2) propagate in three dimensions, 3) synthesize matrix, 4) differentiate, and 5) form sinusoids that facilitate mass transfer. Space cell culture is conducted in flight bioreactors and in static incubators. Cells grown in microgravity are: bovine cartilage, promyelocytic leukemia, kidney proximal tubule cells, adrenal medulla, breast and colon cancer, and endothelium. Cells were cultured in space to test specific hypotheses. Cartilage cells were used to determine structural differences in cartilage grown in space compared to ground-based bioreactors. Results from a 130-day experiment on Mir revealed that cartilage grown in space was substantially more compressible due to insufficient glycosaminoglycan in the matrix. Interestingly, earth-grown cartilage conformed better to the dimensions of the scaffolding material, while the Mir specimens were spherical. The other cell populations are currently being analyzed for cell surface properties, gene expression, and differentiation. Results suggest that some cells spontaneously differentiate in microgravity. Additionally, vast changes in gene expression may occur in response to microgravity. In conclusion, the transition to microgravity may constitute a physical perturbation in cells resulting in unique gene expressions, the consequences of which may be useful in tissue engineering, disease modeling, and space cell biology.

  11. Opening Doors of Opportunity to Develop the Future Nuclear Workforce - 13325

    International Nuclear Information System (INIS)

    Mets, Mindy

    2013-01-01

    The United States' long-term demand for highly skilled nuclear industry workers is well-documented by the Nuclear Energy Institute. In addition, a study commissioned by the SRS Community Reuse Organization concludes that 10,000 new nuclear workers are needed in the two-state region of Georgia and South Carolina alone. Young adults interested in preparing for these nuclear careers must develop specialized skills and knowledge, including a clear understanding of the nuclear workforce culture. Successful students are able to enter well-paying career fields. However, the national focus on nuclear career opportunities and associated training and education programs has been minimal in recent decades. Developing the future nuclear workforce is a challenge, particularly in the midst of competition for similar workers from various industries. In response to regional nuclear workforce development needs, the SRS Community Reuse Organization established the Nuclear Workforce Initiative (NWI R ) to promote and expand nuclear workforce development capabilities by facilitating integrated partnerships. NWI R achievements include a unique program concept called NWI R Academies developed to link students with nuclear career options through firsthand experiences. The academies are developed and conducted at Aiken Technical College and Augusta Technical College with support from workforce development organizations and nuclear employers. Programs successfully engage citizens in nuclear workforce development and can be adapted to other communities focused on building the future nuclear workforce. (authors)

  12. Opening Doors of Opportunity to Develop the Future Nuclear Workforce - 13325

    Energy Technology Data Exchange (ETDEWEB)

    Mets, Mindy [Nuclear Workforce Initiative Program, SRS Community Reuse Organization, P.O. Box 696, Aiken, SC 29802 (United States)

    2013-07-01

    The United States' long-term demand for highly skilled nuclear industry workers is well-documented by the Nuclear Energy Institute. In addition, a study commissioned by the SRS Community Reuse Organization concludes that 10,000 new nuclear workers are needed in the two-state region of Georgia and South Carolina alone. Young adults interested in preparing for these nuclear careers must develop specialized skills and knowledge, including a clear understanding of the nuclear workforce culture. Successful students are able to enter well-paying career fields. However, the national focus on nuclear career opportunities and associated training and education programs has been minimal in recent decades. Developing the future nuclear workforce is a challenge, particularly in the midst of competition for similar workers from various industries. In response to regional nuclear workforce development needs, the SRS Community Reuse Organization established the Nuclear Workforce Initiative (NWI{sup R}) to promote and expand nuclear workforce development capabilities by facilitating integrated partnerships. NWI{sup R} achievements include a unique program concept called NWI{sup R} Academies developed to link students with nuclear career options through firsthand experiences. The academies are developed and conducted at Aiken Technical College and Augusta Technical College with support from workforce development organizations and nuclear employers. Programs successfully engage citizens in nuclear workforce development and can be adapted to other communities focused on building the future nuclear workforce. (authors)

  13. Opening the stable door: new initiatives at the Petrie Museum of Egyptian Archaeology

    Directory of Open Access Journals (Sweden)

    Sally MacDonald

    2000-11-01

    Full Text Available The Petrie Museum ut UCL contains u world-class collection of Egyptian objects that ranges chronologically from early prehistoric to Islamic times, but it is inadequately housed and remains little known outside Egyptology. It has now been designated us of national importance and its stuff have ambitious plans to provide greater access, via the Internet and in other ways, to the 80000 objects it contains.

  14. National capacity mechanisms in the European internal energy market: Opening the doors to neighbours

    International Nuclear Information System (INIS)

    Mastropietro, Paolo; Rodilla, Pablo; Batlle, Carlos

    2015-01-01

    After decades of strong opposition, several European countries are now in the process of implementing some kind of Capacity Remuneration Mechanism (CRM). Unfortunately, these national initiatives seem to aim at energy autarky rather than seeking a wider regional coordination. This situation can significantly affect the potential benefits of an integrated long-term expansion of the European power system. In this paper the regulatory basis for the effective participation of foreign agents in national CRMs is discussed. The authors support that two pillars are required: (1) stronger coordination among TSOs and respect for the Security of Supply Directive and (2) introduce a particular type of firm cross-border nominations associated to the CRMs commitments. These proposed nominations are to be considered only in situations of system stress. As discussed here, this allows not requiring any type of ex-ante cross-border capacity reservation, thus avoiding many of the inefficiencies associated to traditional physical bilateral contracts. -- Highlights: •We discuss the regulatory basis for the effective participation of foreign agents in national CRMs. •Stronger coordination among TSOs and respect for the Security of Supply Directive is required. •A new type of firm cross-border nominations linked to the CRMs commitments should be introduced. •These proposed nominations are to be considered only in situations of system stress. •No ex-ante cross-border capacity reservation would be needed

  15. On the gate of Arctic footsteps: Doors open to foreign high schools

    Science.gov (United States)

    Manno, C.; Pecchiar, I.

    2012-12-01

    With the increased attention on the changing Arctic Region effective science education, outreach and communication need to be higher priorities within the scientific communities. In order to encourage the dissemination of polar research at educational levels foreign high school students and teachers were visiting Tromso University for a week. The project highlights the role of the universities as link between research and outreach. The first aim of this project was to increase awareness of foreign schools on major topics concerning the Arctic issues (from the economic/social to the environmental/climatic point of view). Forty three Italian high school students were involved in the laboratory activities running at the UiT and participated in seminars. Topics of focus were Ocean Acidification, Global Warming and the combined effects with other anthropogenic stressors. During their stay, students interviewed several scientists in order to allow them to edit a "visiting report" and to elaborate all the material collected. Back in Italy they performed an itinerant exhibition (presentation of a short movie, posters, and pictures) in various Italian schools in order to pass on their Arctic education experience. The project highlights the role of University as communicator of "climate related issues" in the international frame of the "new generation" of students.

  16. Examining the British PhD viva: opening new doors or scarring for life?

    Science.gov (United States)

    Carter, Bernie; Whittaker, Karen

    2009-01-01

    The PhD viva -- regardless of its format -- has the potential to be a significant rite of passage for the student. It is an experience that can resonate for months or years afterwards. Part of the challenge is that for everyone involved -- student, supervisory team and examiners -- a degree of end-point uncertainty exists. These ambiguities and tensions are perhaps an inherent part of any examination but are particularly characteristic of the examination of the individual and unique body of work that constitutes the doctoral thesis. In recent years, increased attention has been placed on the processes that surround the examination, aiming to increase transparency, consistency and fairness. However, the process of examining a student and their thesis remains challenging and is surrounded by different agendas, ideologies and practices. This paper examines some of the issues surrounding the PhD viva, primarily focusing on the British viva whilst weaving in commentary about the Australian system.

  17. Opening the Door: How Community Organizations Address the Youth Unemployment Crisis. Executive Summary

    Science.gov (United States)

    Steinberg, Adria; Almeida, Cheryl

    2015-01-01

    Few Americans know the importance of community-based organizations, or CBOs, in helping tens of thousands of undereducated, underemployed young people find a job or go back to school. But the role of CBOs is growing more critical as the business, education, and philanthropic sectors increasingly recognize the need to enable the nation's millions…

  18. Opening the Door: How Community Organizations Address the Youth Unemployment Crisis

    Science.gov (United States)

    Steinberg, Adria; Almeida, Cheryl

    2015-01-01

    At this moment, the role of community-based organizations (CBOs) has never been more important. The country is facing a dual crisis in youth unemployment and low postsecondary completion rates. Both are especially prevalent among low-income and minority young people. Across the nation, nearly 7 million young people are neither in school nor part…

  19. Oil and gas in China: The door opens wider to international oil companies

    International Nuclear Information System (INIS)

    Tao, Wang

    1993-01-01

    This paper reviews new incentives offered by the China National Petroleum Corporation to help develop China's oil and gas fields. The initial offer for bids by foreign investors is for exploration and joint development contracts for western China's Tarim basin. However, the expansion to other basins and areas of China is well underway. It also discusses a pipeline project which will be connect the western China oil and gas fields with the eastern markets, approximately 2,200 miles. A historical review of the oil and gas production and utilization of China is presented along with forecasts of future production. It also provides estimates of gas and oil reserves and information on enhanced recovery techniques used to maintain a stable production level. The second half of the paper is an interview with Dr. Wang Tao, a PhD graduate of Moscow's Petroleum Institute, and president of the China National Petroleum Corporation. He reviews the government policies with regards to foreign investment in his country

  20. Major unsolved points in adult neurogenesis: doors open on a translational future?

    Directory of Open Access Journals (Sweden)

    Paolo ePeretto

    2014-06-01

    Full Text Available The ultimate goal of exploiting adult neurogenesis (AN as a source of cell replacement is far from being achieved. In spite of many data gathered during the last two decades on homeostatic and reactive neurogenesis, it is evident that such knowledge is not sufficient for granting translational outcomes. By asking the question whether AN research field has to be considered as a dead end in such a perspective, here we review some major unresolved issues: multifaceted evolutionary constraints emerged in mammals, stem/progenitor cell type/availability and tissue permissivity, the possible impact on other brain functions and/or interplay with other forms of plasticity, and relevance in humans. We suggest that full understanding of AN biological processes is an essential step to their possible exploitation for brain repair, and that further fundamental, multidisciplinary research is required before translational outcomes can be reached. Scientist's attitude and their communication skills are also important. To avoid overestimation of AN reparative potential, more distant goals of cell replacement should be kept clearly distinct from restorative approaches involving AN plasticity, both representing translational perspectives.

  1. Opening the Doors to Medical Education from the Victorian Era to the Present.

    Science.gov (United States)

    Tom, Stephen C.

    1997-01-01

    Analyzes three distinct periods that characterize women's efforts to become successful physicians: the Victorian era, the first 70 years of the 1900s, and the past twenty years. Compares social, historical, and scientific factors which have affected the number of enrollments and graduations by women. (EMK)

  2. A Reggio-Inspired Music Atelier: Opening the Door between Visual Arts and Music

    Science.gov (United States)

    Hanna, Wendell

    2014-01-01

    The Reggio Emilia approach is based on the idea that every child has at least, "one hundred languages" available for expressing perspectives of the world, and one of those languages is music. While all of the arts (visual, music, dance, drama) are considered equally important in Reggio schools, the visual arts have been particularly…

  3. The three keys to quality customer service: opening the doors to exceptional performance.

    Science.gov (United States)

    Myers, Pennie; Nance, Don W

    2002-01-01

    Excellence in customer service requires three things. The first is a commitment to a set of principles. These principles reflect beliefs and assumptions that people are valuable and deserve to be treated with dignity and respect. This commitment is expressed to customers by an adherence to six customer-friendly processes and by personnel who possess a high level of skill in the behaviors that make up customer service. When these three requirements are met, laboratorians not only maintain a competitive edge but also fulfill their mission as health-care professionals.

  4. Social Media: Opening New Doors for the Domestic Tourism Industry in Albania

    Directory of Open Access Journals (Sweden)

    Vjollca Hysi

    2015-04-01

    Full Text Available The online word is becoming every day more and more important for the tourism industry. Through different technologies, it has made the possibility to ease the way people search and decide for their own travel destination, the way they pick their accommodation and their traveling medium. In particular the online social media, as part of the online word, has created new opportunities for interaction and communication between people. Today individuals have the opportunity to share knowledge, opinions and experiences through online communication. Also their impact goes even further by influencing the behavior of other users in the process of buying. This article will be focused on the usage of Facebook social media platform, arranging a content analysis regarding the different social media tools to engage and interact. This will serve as small step in understanding how domestic business and tourism industry are using social platforms to engage more users and increase their business performance.

  5. Tendances Carbone no. 76 'Doha opens partway the door to shift to -25% for the EU'

    International Nuclear Information System (INIS)

    Morel, Romain; Leguet, Benoit

    2013-01-01

    Among the publications of CDC Climat Research, 'Tendances Carbone' bulletin specifically studies the developments of the European market for CO 2 allowances. This issue addresses the following points: The Doha Conference in Qatar followed two conferences that yielded relatively significant results, namely Cancun (2010) and Durban (2011). These previous conferences had most notably agreed on a second commitment period for the Kyoto Protocol (KP-CP2), begun a negotiation process aimed at achieving an international post-2020 agreement, as well as furthered progress on the issue of financing. The aim of the Doha Conference was therefore to provide a link between the process drawn up by the Bali Road-map (2007) and the one launched in Durban in 2011, with the aim of arriving at an international post-2020 agreement. In the end, the Doha Conference enabled the definition of the rules of the second period of the Kyoto protocol and provided direction for a global agreement in 2015, but was however unable to give a strong signal on the issue of funding

  6. Battlefield acupuncture: Opening the door for acupuncture in Department of Defense/Veteran's Administration health care.

    Science.gov (United States)

    Walker, Patricia Hinton; Pock, Arnyce; Ling, Catherine G; Kwon, Kyung Nancy; Vaughan, Megan

    2016-01-01

    Battlefield acupuncture is a unique auricular acupuncture procedure which is being used in a number of military medical facilities throughout the Department of Defense (DoD). It has been used with anecdotal published positive impact with warriors experiencing polytrauma, post-traumatic stress disorder, and traumatic brain injury. It has also been effectively used to treat warriors with muscle and back pain from carrying heavy combat equipment in austere environments. This article highlights the history within the DoD related to the need for nonpharmacologic/opioid pain management across the continuum of care from combat situations, during evacuation, and throughout recovery and rehabilitation. The article describes the history of auricular acupuncture and details implementation procedures. Training is necessary and partially funded through DoD and Veteran's Administration (VA) internal Joint Incentive Funds grants between the DoD and the VA for multidisciplinary teams as part of a larger initiative related to the recommendations from the DoD Army Surgeon General's Pain Management Task Force. Finally, Uniformed Services University of the Health Sciences School of Medicine and Graduate School of Nursing faculty members present how this interdisciplinary training is currently being integrated into both schools for physicians and advanced practice nurses at the Uniformed Services University of the Health Sciences. Current and future research challenges and progress related to the use of acupuncture are also presented. Published by Elsevier Inc.

  7. Early Intervention Programs: Opening the Door to Higher Education. ERIC Digest.

    Science.gov (United States)

    Fenske, Robert H.; Geranios, Christine A.; Keller, Jonathan E.; Moore, David E.

    This digest summarizes a larger document of the same title which examines early intervention programs providing services and resources to encourage low-income/minority youth to finish high school and enter college. It notes provisions of federal law which encourage such programs and the unifying mission of the National Early Intervention…

  8. Portal to the World: AIHEC Virtual Library Opens Doors for Native Research

    Science.gov (United States)

    Kirby, Jane

    2004-01-01

    The Internet keeps growing at lightning speed. Now, "tribal college" students have a tool to assist them in locating accurate information quickly: the American Indian Higher Education Consortium (AIHEC) Virtual Library. The AIHEC Virtual Library provides a focused entryway into the Internet research field. Librarians report that it supplements…

  9. Braudel and Abrams open the door to an insoluble debate: The City

    Directory of Open Access Journals (Sweden)

    Tomás Antônio Moreira

    2016-08-01

    Full Text Available This paper looks to understand the definitions of the city to enrich the new reflections, in the current days. The starting point for reflection is the confrontation of positions in the understanding of the urban phenomenon, the city, by Fernand Braudel and Philip Abrams, later to emerge in front of the dilemma posed in the confrontation of these two authors, samplings of the main elaborate theorizing on City. Among the findings, it is emphasized that the names of propositions about the city seeking to account for the dynamic evolution of human settlements: métapole, edge city and tecnocity.

  10. Opening the Classroom Door: Professional Learning Communities in the Math and Science Partnership Program

    Science.gov (United States)

    Hamos, James E.; Bergin, Kathleen B.; Maki, Daniel P.; Perez, Lance C.; Prival, Joan T.; Rainey, Daphne Y.; Rowell, Ginger H.; VanderPutten, Elizabeth

    2009-01-01

    This article looks at how professional learning communities (PLCs) have become an operational approach for professional development with potential to de-isolate the teaching experience in the fields of science, technology, engineering, and mathematics (STEM). The authors offer a short synopsis of the intellectual origins of PLCs, provide multiple…

  11. Keeping the door open: Exploring experiences of, and responses to, university students who disclose mental illness

    Directory of Open Access Journals (Sweden)

    Donna McAuliffe

    2012-06-01

    Full Text Available University educators increasingly manage situations where students disclose serious mental health issues. This is a significant issue, particularly for health and human service professions, as the importance of valuing the lived experience of mental illness lies alongside concerns for professional practice standards. Thus the responsibilities of students to disclose their mental health status and the responsibilities of Universities to provide appropriate support within established disability frameworks must be clear. However, students often do not know who they should disclose to, what will happen to disclosed information, and who has access to this information. Student's often fear embarrassment, stigma, and shame about disclosing mental illness, which is compounded by the diverse attitudes, experiences, and beliefs of educators. Consequently, this paper will review existing literature on university responses to, and students’ experiences of, mental illness in order to set a research agenda for this topic. The authors argue that such research must be undertaken urgently, in a context of inclusivity in higher education that gives voice to the experiences of students, their families and carers, university staff, and practitioners in the field.

  12. Opening the Door to Zero New HIV Infections in Closed Settings

    OpenAIRE

    Torriente, Anna; Tadion, Alexander; Hsu, Lee-Nah

    2016-01-01

    Abstract Prisons and other closed settings are high-risk environments for HIV and tuberculosis (TB) transmission. Prisoners often experience overcrowded living conditions and violence?including sexual assault?increasing their vulnerability to HIV and TB. However, high infection rates in prisons affect both prisoners and prison employees. Both groups, in interacting with their families and their communities, represent a potential risk of HIV transmission outside the prison setting. National HI...

  13. Opening the Door to Zero New HIV Infections in Closed Settings.

    Science.gov (United States)

    Torriente, Anna; Tadion, Alexander; Hsu, Lee-Nah

    2016-06-01

    Prisons and other closed settings are high-risk environments for HIV and tuberculosis (TB) transmission. Prisoners often experience overcrowded living conditions and violence-including sexual assault-increasing their vulnerability to HIV and TB. However, high infection rates in prisons affect both prisoners and prison employees. Both groups, in interacting with their families and their communities, represent a potential risk of HIV transmission outside the prison setting. National HIV and TB strategies should therefore include measures to prevent transmission and increase access to HIV-related services in prisons. Courts have progressively recognized the human rights of prisoners, including the right to health and access to HIV-related services. A number of national and regional court decisions have affirmed that prison authorities have a duty of care to prisoners and an obligation to ensure that prisoners have access to HIV prevention measures and treatment. Policies and programs on HIV, AIDS, and TB for prison workplaces that are aligned with the ILO's international labor standards can benefit both prisoners and prison employees. In particular, the ILO's HIV and AIDS Recommendation, 2010 (No. 200) affirms the principle of universal access to HIV services and provides guidance for the HIV/TB response in prison settings.

  14. Una puerta abierta a la profesionalidad pedagógica A door opened to pedagogical proficiency

    Directory of Open Access Journals (Sweden)

    Sonia Socarrás Sánchez

    2006-04-01

    Full Text Available Este trabajo es una experiencia pedagógica que se desarrolla en el Instituto Superior de Ciencias Médicas de Camagüey, se aplica desde el año 2003 y se extiende hasta este curso 2005-2006. Se tiene como base el trabajo desarrollado como profesor guía con el grupo D-11, F-16 y el testigo de primer año de Medicina, en los cuales se ha aplicado una estrategia pedagógica y a la misma se le adicionaron métodos educativos y un sistema de técnicas participativas, lo que ha dado resultados satisfactorios. El trabajo tiene como objetivo proponer una alternativa metodológica para el trabajo educativo del profesor guía en el proceso de fortalecimiento de los valores. El mismo brinda elementos teóricos relacionados con el trabajo educativo, diversos métodos y técnicas para realizar el mismo de manera más eficiente y se da a conocer la importancia del profesor guía en este proceso. Entre los resultados se destacan la formulación de pasos metodológicos para poder realizar una estrategia pedagógica, el diseño de una herramienta de trabajo para el profesor guía, indicaciones para efectuar el turno de reflexión y debate, la aplicación del material elaborado en la superación de los profesores guías que pertenecen al comité horizontal del primer año de medicinaThis work is a pedagogic experience developed in the High Medical School of Camaguey, it is applied since 2003 and it extends to the school year 2005-2006. It is based on the work developed by the adviser teachers of two groups and witness classes from first year, in which pedagogic strategies have been applied adding educational methods and a participative techniques system, with satisfactory results. This work has as objective to propose a methodological alternative for the advicer teachers´ educational work in the process of strengthen values. It offers theoretical elements related to the educational work, diverse methods and techniques to carry out it in a more efficient way, and it is showed the importance of the adviser teacher in the process. Among the results stand out the formulation of methodological steps to be able to carry out a pedagogic strategy, the design of a tool for the adviser teacher, indications to develop the debate and reflection shifts, the application of the material elaborated in the adviser teachers´ preparation in the first year horizontal committee.

  15. Opening Lab Doors to High School Students: Keys to a Successful Engagement

    Science.gov (United States)

    Slayton, Rebecca M.; Nelson, Keith A.

    2005-01-01

    A project to invite high school students into research laboratories to plan and carry out an investigation over several weeks, using the sophisticated equipment available there, can help to break down social barriers and enhance outreach activities.

  16. Opening the Door for IT Leadership Opportunities: New Voices from the Field

    Science.gov (United States)

    Drury, Marilyn

    2009-01-01

    The growth and increasing criticality of the CIO role in higher education suggests the importance of recognizing and understanding the characteristics of successful CIOs and the environments supporting their success, with the goal of developing new leaders. Although the literature, in general, provides a rich knowledge base concerning IT…

  17. Opening Doors to Nursing Degrees: Time for Action. A Proposal from Ontario's Colleges

    Science.gov (United States)

    Colleges Ontario, 2015

    2015-01-01

    This report argues that Ontario must expand the educational options for people who want to become registered nurses (RNs). It argues that the change Ontario requires is to authorize colleges to offer their own high-quality nursing degrees. Until 2005, about 70 per cent of Ontario's RNs were educated at colleges. Today, tens of thousands of RNs who…

  18. Court opens door to more claims under Red Cross HIV compensation fund.

    Science.gov (United States)

    Franklin, Tim

    2005-12-01

    The Ontario Superior Court has allowed families of deceased individuals who contracted HIV from tainted blood to proceed with their claims against the Canadian Red Cross for compensation despite the existence of a compensation plan and fund.

  19. Opening the Schoolhouse Doors: Tax Credits and Educational Access in Alabama

    Science.gov (United States)

    Carpenter, Dick M., II.; Erickson, Angela C.

    2014-01-01

    In 2013, Alabama adopted the Alabama Accountability Act, an education reform measure that includes two new school choice programs that extend a lifeline to Alabama students trapped in failing public schools. One program offers a tax credit to help offset the cost of tuition for families who move their children from public schools designated as…

  20. Secure Borders and Open Doors: Preserving Our Welcome to the World in an Age of Terrorism

    National Research Council Canada - National Science Library

    2008-01-01

    As an international beacon of freedom and economic opportunity, and offering unique and attractive opportunities for international businesspeople, students, researchers, and tourists, America has long...

  1. Finding Difference: Nemo and Friends Opening the Door to Disability Theory

    Science.gov (United States)

    Preston, Daniel L.

    2010-01-01

    While middle school and high school students may have watched the Disney and Disney/Pixar films when they were younger, chances are they did not do so with a critical eye toward difference and disability, despite the fact that these films serve as excellent tools for teaching about difference. Recent estimates label 20% of the world's population…

  2. Shopping for Jobs: Mall Internship Program Opens Doors for HVAC Students.

    Science.gov (United States)

    Nolot, Terry

    1995-01-01

    Ivy Tech State College uses River Falls, a shopping mall, as an enormous heating, ventilation, and air conditioning laboratory. Students spend Saturdays working with full-time technicians getting invaluable training and experience. Students see the program as a professional opportunity and a direct route to jobs. (JOW)

  3. Opening Doors: Teaching LGBTQ-Themed Young Adult Literature for an Inclusive Curriculum

    Science.gov (United States)

    Batchelor, Katherine E.; Ramos, Maria; Neiswander, Samantha

    2018-01-01

    LGBTQ themes are often neglected in many schools' curriculum. Currently, an LGBTQ-inclusive curriculum framework is not required in most school districts across the county. Therefore, it is important to understand how teachers regard LGBTQ issues; how they address the needs of students in the middle school and high school English classroom who…

  4. Young people’s writing in senior English classrooms: Opening the classroom door

    OpenAIRE

    LOUISE ANNE PIVA

    2018-01-01

    The thesis is a practitioner inquiry that examines the teaching of writing to Year 12 students in the subject of English. It uses narrative inquiry to examine the teaching and learning of writing over the course of one academic year. It focuses on the dialogue between the teacher, her students and others as well as the contextual and socio-cultural factors that influence and mediate the teaching and learning of writing.

  5. Usage of radiography techniques for restoration of Cizre Mardin Ulucami door

    International Nuclear Information System (INIS)

    Tugrul, B.; Sungur, F.; Gorkem, A.; Olcer, N.

    1986-01-01

    In this study, one of the two sections of Cizre-Mardin Ulucami door is investigated by x-ray radiography technique whether it has some patterns similar to those which were discovered during the restoration of the first section of the door. Some painted and traced parts have been fixed and torn down, cleared and investigated. In the study, many pieces of the first part of the door including the second door have been investigated by x-ray radiography technique and have been evaluated. Furthermore, neutrography has been applied on some painted parts for the investigation of traces of painting. (author)

  6. Open Days – The final countdown

    CERN Multimedia

    2008-01-01

    In only a few days CERN will open its doors to everyone! Thousands of volunteers are working very hard so that your visit will be both mind-boggling and fun. Where is the coldest place in the Universe? How can you move 30 tonne magnets with sub-millimetre precision? Why do you need huge detectors to look at the infinitely small? There’s only one way to find the answers: Come to CERN!

  7. Inflatable door seals - reduced maintenance and longer service-life

    International Nuclear Information System (INIS)

    Kuran, S.; Wensel, R.; Lazic, M.

    1995-01-01

    Inflatable door seals, designed more than a quarter of a century ago, have given good service in Canadian and overseas CANDU reactors. These thin-walled elastomeric seals have been exposed to many thousands of cycles of inflation and deflation, various types of aging (temperature, radiation and time), ozone degradation, abrasion, pinching, stiction, cracking and installation damage. The fact that they have operated successfully as part of the reactor building containment structure - subjected to the same pressures and temperatures as those for the thick reinforced concrete walls and steel doors highlights the achievement of these thin rubber seals. However, in the last decade, the rubber industry has developed new compounds that are more resistant to radiation, temperature, and time-dependent aging. Components manufactured from such compounds are less prone to hardening, stress cracking and permanent set; thereby saving on replacement costs, inventory and overall maintenance. This paper discusses development and testing of recent material and design changes to inflatable seals, and addresses various practical issues faced by the operations engineers and maintainers using these seals. (author)

  8. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  9. Multidimensional process discovery

    NARCIS (Netherlands)

    Ribeiro, J.T.S.

    2013-01-01

    Typically represented in event logs, business process data describe the execution of process events over time. Business process intelligence (BPI) techniques such as process mining can be applied to get strategic insight into business processes. Process discovery, conformance checking and

  10. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  11. Toxins and drug discovery.

    Science.gov (United States)

    Harvey, Alan L

    2014-12-15

    Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

  12. Defining Creativity with Discovery

    OpenAIRE

    Wilson, Nicholas Charles; Martin, Lee

    2017-01-01

    The standard definition of creativity has enabled significant empirical and theoretical advances, yet contains philosophical conundrums concerning the nature of novelty and the role of recognition and values. In this work we offer an act of conceptual valeting that addresses these issues and in doing so, argue that creativity definitions can be extended through the use of discovery. Drawing on dispositional realist philosophy we outline why adding the discovery and bringing into being of new ...

  13. On the antiproton discovery

    International Nuclear Information System (INIS)

    Piccioni, O.

    1989-01-01

    The author of this article describes his own role in the discovery of the antiproton. Although Segre and Chamberlain received the Nobel Prize in 1959 for its discovery, the author claims that their experimental method was his idea which he communicated to them informally in December 1954. He describes how his application for citizenship (he was Italian), and other scientists' manipulation, prevented him from being at Berkeley to work on the experiment himself. (UK)

  14. Discovery Driven Growth

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2009-01-01

    Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

  15. The π discovery

    International Nuclear Information System (INIS)

    Fowler, P.H.

    1988-01-01

    The paper traces the discovery of the Π meson. The discovery was made by exposure of nuclear emulsions to cosmic radiation at high altitudes, with subsequent scanning of the emulsions for meson tracks. Disintegration of nuclei by a negative meson, and the decay of a Π meson were both observed. Further measurements revealed the mass of the meson. The studies carried out on the origin of the Π-mesons, and their mode of decay, are both described. (U.K.)

  16. Polar Domain Discovery with Sparkler

    Science.gov (United States)

    Duerr, R.; Khalsa, S. J. S.; Mattmann, C. A.; Ottilingam, N. K.; Singh, K.; Lopez, L. A.

    2017-12-01

    The scientific web is vast and ever growing. It encompasses millions of textual, scientific and multimedia documents describing research in a multitude of scientific streams. Most of these documents are hidden behind forms which require user action to retrieve and thus can't be directly accessed by content crawlers. These documents are hosted on web servers across the world, most often on outdated hardware and network infrastructure. Hence it is difficult and time-consuming to aggregate documents from the scientific web, especially those relevant to a specific domain. Thus generating meaningful domain-specific insights is currently difficult. We present an automated discovery system (Figure 1) using Sparkler, an open-source, extensible, horizontally scalable crawler which facilitates high throughput and focused crawling of documents pertinent to a particular domain such as information about polar regions. With this set of highly domain relevant documents, we show that it is possible to answer analytical questions about that domain. Our domain discovery algorithm leverages prior domain knowledge to reach out to commercial/scientific search engines to generate seed URLs. Subject matter experts then annotate these seed URLs manually on a scale from highly relevant to irrelevant. We leverage this annotated dataset to train a machine learning model which predicts the `domain relevance' of a given document. We extend Sparkler with this model to focus crawling on documents relevant to that domain. Sparkler avoids disruption of service by 1) partitioning URLs by hostname such that every node gets a different host to crawl and by 2) inserting delays between subsequent requests. With an NSF-funded supercomputer Wrangler, we scaled our domain discovery pipeline to crawl about 200k polar specific documents from the scientific web, within a day.

  17. Onderzoek naar voorkomen van zachte vruchten bij courgette in de afzetketen door optimale watergift

    NARCIS (Netherlands)

    Wijk, van C.A.P.; Wilms, J.A.M.

    2008-01-01

    Vochttekort tijdens de teelt werd door de telers als mogelijke oorzaak gezien. Het ‘weer’ is geen groeifactor waarop de tuinder kan sturen. Vochttekort is wel bij te sturen door water geven. Ter toetsing van de invloed van vochttekort is in 2006 in een late zomer/herfstteelt een proef aangelegd in

  18. Evaluatie van het nieuwe RVV door weggebruikers : een samenvattend verslag van de nameting.

    NARCIS (Netherlands)

    Wittink, R.D.

    1993-01-01

    The new Dutch traffic regulations (RVV of 1990) have been effective since 1 November 1991. This paper presents the results of a door-to-door questionnaire survey among 655 sixteen year olds and older persons in order to investigate their knowledge and opinions about the new RVV. This survey carried

  19. 24 CFR 3280.403 - Standard for windows and sliding glass doors used in manufactured homes.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Standard for windows and sliding... AND SAFETY STANDARDS Testing § 3280.403 Standard for windows and sliding glass doors used in manufactured homes. (a) Scope. This section sets the requirements for prime windows and sliding glass doors...

  20. Bluetooth enables in-door mobile location services

    DEFF Research Database (Denmark)

    Thongthammachart, Saowanee; Olesen, Henning

    2003-01-01

    Several technologies can be applied to enable mobile location services, but most of them suffer from limited accuracy and availability. GPS can solve the problem of determining the location of users in most outdoor situations, but an end-user position inside a building cannot be pinpointed. Other...... mobile location techniques can also provide the user's position, but the accuracy is rather low. In order to improve the accuracy and make location-based services really attractive, existing approaches must be supplemented by new technologies. Wireless short-range technologies like Bluetooth could...... be candidates for solving these problems. This paper shows that Bluetooth can act as a key enabler of mobile location services in an in-door environment. The advantage of Bluetooth technology is, that it can provide rather precise location data inside a building or hotspot area, while the Bluetooth terminal...

  1. Simulation of the noise transmission through automotive door seals

    CERN Document Server

    Hazir, Andreas

    2016-01-01

    Andreas Hazir is investigating the door seal contribution to the interior noise level of production vehicles. These investigations contain experimental contribution analyses of real production vehicles and of academic test cases as well as the development of a simulation methodology for noise transmission through sealing systems and side windows. The simulations are realized by coupling transient computational aeroacoustics of the exterior flow to nonlinear finite element simulations of the structural transmission. By introducing a linear transmission model, the setup and computational costs of the seal noise transmission are significantly reduced, resulting in the feasibility of numerical contribution analyses of real production vehicles. Contents Contribution Analyses of Production Vehicles Acoustic Excitation versus Aeroacoustic Excitation Development of a Simulation Methodology Sensitivity Analysis of Noise Transmission Simulations Target Groups Researchers and students in the field of automotive engineer...

  2. Doors and thresholds: Jeddi's approach to psychiatric disorders.

    Science.gov (United States)

    Devisch, R; Vervaeck, B

    1986-01-01

    Professor Essedik Jeddi and his team have introduced a most significant institutional and therapeutic innovation at the Ibn Rochd and Pinel section of the Razi university long-term mental hospital in Tunis (Tunisia). The innovation focuses upon the ambiguity of doors and boundaries in the mental asylum. Doors and walls influence the rhythm of activity and the nature of contact between patients, therapists and the wider society and culture. If they are very rigid, they may disjoin the patient from him- or herself, from his/her body, social network and culture. On the other hand, if such boundaries are completely neglected they may merge these related dimensions as undifferentiated entities. Jeddi's innovation is primarily concerned with placing the spatio-temporal experience of the body and the intimate interpersonal interaction at the centre of treatment. It aims at establishing creative modes of expression, interaction and exchange such as tea-sessions, dancing, singing, verbal communication, clay-modelling, figurative or plastic expression, agricultural works. These relationships mediate and differentiate at the same time between the patient, his/her body-self, and his/her social and cultural world, thus avoiding both the disjunction and the merging. It would seem that the activities concerned with the distinction between 'inside' and 'outside', peasant and urban, self and other (e.g. dancing and singing) are of paramount importance in bringing about such mediating and differentiating relationships. In the present study we limit ourselves to one particularly revealing therapeutic activity, namely dancing to live music. Jeddi's innovation is a unique blend of current developments in psychiatry and psychotherapy with Arabo-Islamic science and philosophy.

  3. Telling About Southern Fluctuations: Elizabeth Spencer at the Back Door

    Directory of Open Access Journals (Sweden)

    Gérald PRÉHER

    2011-06-01

    Full Text Available Le troisième roman d’Elizabeth Spencer, The Voice at the Back Door (1956, appartient à son cycle du Mississippi. Il traite des relations raciales et de la violence sudiste, deux thèmes qui n’avaient pas bonne presse à cette époque puisque le mouvement pour les droits civiques débutait. Le roman rappelle L’intrus (1948 de Faulkner en ce qu’il met en scène la recherche du coupable du meurtre d’un homme blanc. Cet article analyse la façon dont Spencer dépeint les manières du Sud en s’interrogeant sur les relations raciales. Le roman est également lu dans le contexte de sa publication puisque Spencer fut perçue comme une traîtresse par les Sudistes. Spencer utilise des sujets impopulaires pour révéler le paradoxe au cœur de la manière de vivre sudiste et montre combien le passé se rejoue constamment dans le présent.Elizabeth Spencer’s third novel, The Voice at the Back Door (1956, is part of her Mississippi cycle. It deals with race relations and southern violence, two highly controversial issues at the time since the Civil Rights Movements were beginning. The novel, reminiscent of William Faulkner’s Intruder in the Dust (1948, stages the search for a culprit after the murder of a white man. This paper focuses on Spencer’s portrait of southern manners and interracial relationships and analyzes the novel in the context of its publication. It will show that Spencer uses unpopular topics to expose the paradox at the core of the southern way of life and show that the past is constantly reenacted in the present.

  4. Ruimte in regels: 10 succesvolle voorbeelden op wet en regelgeving binnen ruimtelijke ordening voor multifunctionele landbouw voor en door gemeenten

    NARCIS (Netherlands)

    Schoorlemmer, H.B.; Waal, van der B.H.C.; Oppedijk van Veen, J.; Migchels, G.; Mul, M.F.

    2007-01-01

    Deze VNG brochure geeft een overzicht van 10 succesvolle voorbeelden op wet en regelgeving binnen ruimtelijke ordening voor multifunctionele landbouw voor en door gemeenten. Van traditionele bestemmingsplannen naar een nieuw, ontwikkelingsgericht beleid. De brochure is samengesteld door PPO

  5. Balancing Open Access with Academic Standards: Implications for Community College Faculty

    Science.gov (United States)

    Gabbard, Anita; Mupinga, Davison M.

    2013-01-01

    Community colleges act as the gateway for students to higher education. Many of these colleges realize this mission through open-door policies where students lacking in basic reading, writing, and mathematics skills can enroll. But, this open-access policy often creates challenges when meeting academic standards. Based on data collected from…

  6. Door-to-door survey of major neurological disorders (project in Al Quseir City, Red Sea Governorate, Egypt

    Directory of Open Access Journals (Sweden)

    El Tallawy HN

    2013-05-01

    Full Text Available Hamdy NA El Tallawy,1 Wafaa MA Farghaly,1 Tarek A Rageh,1 Ghaydaa A Shehata,1 Reda Badry,1 Nabil A Metwally,2 Esam A El Moselhy,2 Mahmoud Hassan,2 Mohamed A Sayed,3 Ahmed A Waris,1 Yaser Hamed,2 Islam Shaaban,2 Mohamed A Hamed,1 Mahmoud Raafat Kandil11Department of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Neurology and Public Health, Faculty of Medicine, Al-Azhar University (Assiut branch, Assiut, Egypt; 3Department of Neurology, Faculty of Medicine, Sohag University, Sohag, EgyptAbstract: A door-to-door survey, including every household, was conducted for all inhabitants of Al Quseir City (33,283, Red Sea Governorate, Egypt by three specialists of neurology as well as nine senior staff members of neurology and 15 female social workers to assess the epidemiology of major neurological disorders. Over six phases, from July 1, 2009 to January 31, 2012, screening of all eligible people in the population was carried out, by which case ascertainment of all major neurological disorders included in the study was done according to the accepted definitions and diagnostic criteria of the World Health Organization. The order of frequency of prevalence of the studied neurological disorders was dementia (3.83% for those aged > 60 years, migraine (2.8% for those aged > 8 years, stroke (6.2/1000 for those aged > 20 years, epilepsy (5.5/1000, Parkinson’s disease (452.1/100,000 for those aged > 40 years, cerebral palsy (3.6/1000 among children 37 years, chorea (21.03/100,000, athetosis (15/100,000, and multiple sclerosis (13.74/100,000. The incidence rates of stroke, epilepsy, and Bell’s palsy were 181/100,000, 48/100,000, and 98.9/100,000 per year, respectively.Keywords: prevalence, incidence, neurological disorders

  7. Discovery of charm

    International Nuclear Information System (INIS)

    Goldhaber, G.

    1984-11-01

    In my talk I will cover the period 1973 to 1976 which saw the discoveries of the J/psi and psi' resonances and most of the Psion spectroscopy, the tau lepton and the D 0 ,D + charmed meson doublet. Occasionally I will refer briefly to more recent results. Since this conference is on the history of the weak-interactions I will deal primarily with the properties of naked charm and in particular the weakly decaying doublet of charmed mesons. Most of the discoveries I will mention were made with the SLAC-LBL Magnetic Detector or MARK I which we operated at SPEAR from 1973 to 1976. 27 references

  8. Design, development and testing of a high speed door for a blast containment fixture

    International Nuclear Information System (INIS)

    Shapiro, C.

    1991-01-01

    This paper reports that the concept of a large door able to close over a three foot diameter hole in less than 50 milliseconds evolved during the design of a test containment fixture at the Idaho National Engineering laboratory (INEL). This facility was designed for use at the Aberdeen Proving Ground (APG) in Aberdeen, Maryland. EPA regulations required new technologies for blast containment at APG, which culminated in the design of the blast chamber with a high speed door at its entrance. The main requirement of the fixture is to contain large explosion pressure pulses and explosive by-products during a variety of test scenarios. The door was designed to allow entrance of test projectiles and then to close over the entrance hole to contain explosive by-products inside the fixture. The speed of the projectile and the resultant blast pressure pulse required door closure within 56 msec. Analytical modelling of the door closure indicated velocities of up to 150 ft/sec before impact, for closure within the required time. Lightweight materials were used for the moving parts to minimize this impact force, including aluminum honeycomb composite panels and energy absorbers. Actuation was accomplished with a standard explosive bolt. High pressure nitrogen accelerated the door during closure. Time measurement for the door closer were obtained using high speed video equipment

  9. Discovery: Pile Patterns

    Science.gov (United States)

    de Mestre, Neville

    2017-01-01

    Earlier "Discovery" articles (de Mestre, 1999, 2003, 2006, 2010, 2011) considered patterns from many mathematical situations. This article presents a group of patterns used in 19th century mathematical textbooks. In the days of earlier warfare, cannon balls were stacked in various arrangements depending on the shape of the pile base…

  10. Discovery and Innovation

    African Journals Online (AJOL)

    Discovery and Innovation is a journal of the African Academy of Sciences (AAS) ... World (TWAS) meant to focus attention on science and technology in Africa and the ... of Non-wood Forest Products: Potential Impacts and Challenges in Africa ...

  11. Discovery of TUG-770

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth; Hansen, Steffen V F; Urban, Christian

    2013-01-01

    Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical...

  12. The discovery of fission

    International Nuclear Information System (INIS)

    McKay, H.A.C.

    1978-01-01

    In this article by the retired head of the Separation Processes Group of the Chemistry Division, Atomic Energy Research Establishment, Harwell, U.K., the author recalls what he terms 'an exciting drama, the unravelling of the nature of the atomic nucleus' in the years before the Second World War, including the discovery of fission. 12 references. (author)

  13. The Discovery of America

    Science.gov (United States)

    Martin, Paul S.

    1973-01-01

    Discusses a model for explaining the spread of human population explosion on North American continent since its discovery 12,000 years ago. The model may help to map the spread of Homo sapiens throughout the New World by using the extinction chronology of the Pleistocene megafauna. (Author/PS)

  14. Hand sanitizer-dispensing door handles increase hand hygiene compliance: a pilot study.

    Science.gov (United States)

    Babiarz, Lukasz S; Savoie, Brent; McGuire, Mark; McConnell, Lauren; Nagy, Paul

    2014-04-01

    Improving rates of hand hygiene compliance (HHC) has been shown to reduce nosocomial disease. We compared the HHC for a traditional wall-mounted unit and a novel sanitizer-dispensing door handle device in a hospital inpatient ultrasound area. HHC increased 24.5%-77.1% (P sanitizer-dispensing door handle, whereas it remained unchanged for the other rooms. Technical improvements like a sanitizer-dispensing door handle can improve hospital HHC. Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  15. Esophagectomy - open

    Science.gov (United States)

    ... Lewis esophagectomy, Blunt esophagectomy; Esophageal cancer - esophagectomy - open; Cancer of the esophagus - esophagectomy - open ... lining of the esophagus that can lead to cancer ( Barrett esophagus ) Severe trauma Destroyed esophagus Severely damaged stomach

  16. The Vaccination of 35,000 Dogs in 20 Working Days Using Combined Static Point and Door-to-Door Methods in Blantyre, Malawi.

    Directory of Open Access Journals (Sweden)

    Andrew D Gibson

    2016-07-01

    Full Text Available An estimated 60,000 people die of rabies annually. The vast majority of cases of human rabies develop following a bite from an infected dog. Rabies can be controlled in both human and canine populations through widespread vaccination of dogs. Rabies is particularly problematic in Malawi, costing the country an estimated 13 million USD and 484 human deaths annually, with an increasing paediatric incidence in Blantyre City. Consequently, the aim of this study was to vaccinate a minimum of 75% of all the dogs within Blantyre city during a one month period. Blantyre's 25 administrative wards were divided into 204 working zones. For initial planning, a mean human:dog ratio from the literature enabled estimation of dog population size and dog surveys were then performed in 29 working zones in order to assess dog distribution by land type. Vaccination was conducted at static point stations at weekends, at a total of 44 sites, with each operating for an average of 1.3 days. On Monday to Wednesday, door-to-door vaccination sessions were undertaken in the areas surrounding the preceding static point stations. 23,442 dogs were vaccinated at static point stations and 11,774 dogs were vaccinated during door-to-door vaccinations. At the end of the 20 day vaccination programme, an assessment of vaccination coverage through door-to-door surveys found that of 10,919 dogs observed, 8,661 were vaccinated resulting in a vaccination coverage of 79.3% (95%CI 78.6-80.1%. The estimated human:dog ratio for Blantyre city was 18.1:1. Mobile technology facilitated the collection of data as well as efficient direction and coordination of vaccination teams in near real time. This study demonstrates the feasibility of vaccinating large numbers of dogs at a high vaccination coverage, over a short time period in a large African city.

  17. The Vaccination of 35,000 Dogs in 20 Working Days Using Combined Static Point and Door-to-Door Methods in Blantyre, Malawi.

    Science.gov (United States)

    Gibson, Andrew D; Handel, Ian G; Shervell, Kate; Roux, Tarryn; Mayer, Dagmar; Muyila, Stanford; Maruwo, Golden B; Nkhulungo, Edwin M S; Foster, Rachel A; Chikungwa, Patrick; Chimera, Bernard; Bronsvoort, Barend M deC; Mellanby, Richard J; Gamble, Luke

    2016-07-01

    An estimated 60,000 people die of rabies annually. The vast majority of cases of human rabies develop following a bite from an infected dog. Rabies can be controlled in both human and canine populations through widespread vaccination of dogs. Rabies is particularly problematic in Malawi, costing the country an estimated 13 million USD and 484 human deaths annually, with an increasing paediatric incidence in Blantyre City. Consequently, the aim of this study was to vaccinate a minimum of 75% of all the dogs within Blantyre city during a one month period. Blantyre's 25 administrative wards were divided into 204 working zones. For initial planning, a mean human:dog ratio from the literature enabled estimation of dog population size and dog surveys were then performed in 29 working zones in order to assess dog distribution by land type. Vaccination was conducted at static point stations at weekends, at a total of 44 sites, with each operating for an average of 1.3 days. On Monday to Wednesday, door-to-door vaccination sessions were undertaken in the areas surrounding the preceding static point stations. 23,442 dogs were vaccinated at static point stations and 11,774 dogs were vaccinated during door-to-door vaccinations. At the end of the 20 day vaccination programme, an assessment of vaccination coverage through door-to-door surveys found that of 10,919 dogs observed, 8,661 were vaccinated resulting in a vaccination coverage of 79.3% (95%CI 78.6-80.1%). The estimated human:dog ratio for Blantyre city was 18.1:1. Mobile technology facilitated the collection of data as well as efficient direction and coordination of vaccination teams in near real time. This study demonstrates the feasibility of vaccinating large numbers of dogs at a high vaccination coverage, over a short time period in a large African city.

  18. From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world

    NARCIS (Netherlands)

    Kastelein, John J. P.; Ross, Colin J. D.; Hayden, Michael R.

    2013-01-01

    On November 2, 2012, Glybera® (alipogene tipovarvec) was the first human gene therapy to receive long awaited market approval in the Western world. This important milestone is expected to open the door to additional gene therapies for the treatment of many diseases in the future. The development of

  19. Open access

    NARCIS (Netherlands)

    Valkenburg, P.M.

    2015-01-01

    Open access week Van 19 tot en met 25 oktober 2015 vond wereldwijd de Open Access Week plaats. Tijdens deze week werden er over de hele wereld evenementen georganiseerd waar open access een rol speelt. Ook in Nederland zijn er diverse symposia, workshops en debatten georganiseerd zoals het debat in

  20. DOORS Syndrome: Phenotype, Genotype and Comparison With Coffin-Siris Syndrome

    NARCIS (Netherlands)

    Campeau, Philippe M.; Hennekam, Raoul C.; Aftimos, Salim; Banka, Siddharth; Begleiter, Michael L.; Bilo, Leonilda; Blair, Edward; Burrage, Lindsay C.; Liu, David S.; de Bie, Isabelle; Félix, Têmis Maria; Giltay, Jacques C.; Gibbs, Richard A.; Giuliano, Fabienne; Hadzsiev, Kinga; Hori, Mutsuki; Kariminejad, Ariana; Kayserili, Hülya; Kerr, Bronwyn; Lee, Brendan H.; Lu, James T.; Male, Alison; Meenakshi, Girish; Mey, Antje; Murray, Mitzi L.; Nair, Lal D. V.; Nampoothiri, Sheela; Newman, William G.; Peluso, Silvio; Peters, Heidi; Powell, R.; Repetto, Gabriela M.; Rump, Patrick; Santos-Simarro, Fernando; Stewart, Fiona; van Bever, Yolande; van den Ende, Jenneke; Wieczorek, Dagmar; Wisniewska, Marzena; Sisodiya, Sanjay M.

    2014-01-01

    DOORS syndrome (Deafness, Onychodystrophy, Osteodystrophy, mental Retardation, Seizures) is characterized mainly by sensorineural deafness, shortened terminal phalanges with small nails of hands and feet, intellectual deficiency, and seizures. Half of the patients with all clinical features have

  1. Resultaten van de proeftuinen van PACT : inclusie door interprofessionele samenwerking in kindvoorzieningen 0-6 jaar

    NARCIS (Netherlands)

    Doornenbal, Jeannette; Balledux, Marielle; Fukkink, Ruben; Spoelstra, Jolanda; van Verseveld, Marloes; van Yperen, Tom

    2018-01-01

    In deze bijdrage worden de onderzoeksresultaten gepresenteerd van de ontwikkelingen in de PACT-proeftuinen om door middel van interprofessionele samenwerking tussen onderwijs, kinderopvang en zorg inclusie van elk kind te realiseren.

  2. The neutron discovery

    International Nuclear Information System (INIS)

    Six, J.

    1987-01-01

    The neutron: who had first the idea, who discovered it, who established its main properties. To these apparently simple questions, multiple answers exist. The progressive discovery of the neutron is a marvellous illustration of some characteristics of the scientific research, where the unforeseen may be combined with the expected. This discovery is replaced in the context of the 1930's scientific effervescence that succeeded the revolutionary introduction of quantum mechanics. This book describes the works of Bothe, the Joliot-Curie and Chadwick which led to the neutron in an unexpected way. A historical analysis allows to give a new interpretation on the hypothesis suggested by the Joliot-Curie. Some texts of these days will help the reader to revive this fascinating story [fr

  3. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  4. Viral pathogen discovery

    Science.gov (United States)

    Chiu, Charles Y

    2015-01-01

    Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remain to be addressed, including the bioinformatics analysis and interpretation of large datasets, these technologies have been successful in rapidly identifying emerging outbreak threats, screening vaccines and other biological products for microbial contamination, and discovering novel viruses associated with both acute and chronic illnesses. Downstream studies such as genome assembly, epidemiologic screening, and a culture system or animal model of infection are necessary to establish an association of a candidate pathogen with disease. PMID:23725672

  5. Fateful discovery almost forgotten

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    The paper reviews the discovery of the fission of uranium, which took place fifty years ago. A description is given of the work of Meitner and Frisch in interpreting the Fermi data on the bombardment of uranium nuclei with neutrons, i.e. proposing fission. The historical events associated with the development and exploitation of uranium fission are described, including the Manhattan Project, Hiroshima and Nagasaki, Shippingport, and Chernobyl. (U.K.)

  6. Effects of Door Width and Human Body Size on Walking Speed

    Directory of Open Access Journals (Sweden)

    Jetthumrong Siwalee

    2016-01-01

    Full Text Available Door width is one of the important factors to concern in layout or facilities design because it affects directly to traffic speed and overall traffic time simultaneously. Nowadays, common assessment method is computer simulation which is still not realistic due to the unchanged speed of model while walking through a door. This research aims to study an effect of door width to individual walking speed. Sixty subjects participated in the experiment and performed task by walking through the door that is set the width as 40, 50, 60, 70, 80, 90 and 100 centimetres. The optical motion capture system was used to determine walking speed. The results showed that Fitts’ law was applied to the participants with high weight. Door width below 70 centimetres significantly affected to changing speed at 0-0.5 m. before the door. Additionally, human size also affected changing speed. The factors include shoulder breadth, weight and interaction between shoulder breadth and weight were found to be significant. These factors explained 54.2% of changing speed.

  7. Study of structural capacity and serviceability affecting the obstruction of residential door

    Directory of Open Access Journals (Sweden)

    Eric Forcael

    Full Text Available The last Chilean earthquake, occurred on February 27, 2010, allowed establishing important patterns of structural failures in reinforced concrete residential buildings; however, limited progress has been made in the study of basic standards of serviceability, such as obstruction of doors. Thus, this study focused on measuring the influence of design specifications and construction criteria of lintels and columns, in terms of obstruction of doors, considering capacity thresholds for certain levels of displacement. The study consisted of the design and construction of a full-scale prototype of a reinforced concrete frame, designed in accordance with all the ACI-318-08 requirements, taking into account typical aspects of geometry and materiality widely used by the real estate industry, for location and size of doors. In order to quantify the structural capacity of the prototype and to study the serviceability of the door, a quasi-static cyclic test was conducted, according to load and displacement protocols specified in FEMA 356 and FEMA 461, which was adjusted by using virtual models based on a static nonlinear analysis called "Pushover". This research verified that, for displacement levels even five times higher than those established by codes considered, the cracking degree was minimal and fully recoverable. It was also found the door evidenced malfunction when the displacements were greater than those specified by design only, validating a high degree of accomplishment of current codes, in terms of capacity and serviceability, when dealing with obstruction of residential doors.

  8. Saving millions by thermal insulation; Miljoenen besparen door goede isolatie

    Energy Technology Data Exchange (ETDEWEB)

    Van der Velden, U. [Nederlands Centrum voor Technische Isolatie NCTI, spijkenisse (Netherlands)

    2009-07-15

    Corrosion under insulation (CUI) can be reduced by the application of a correctly designed, installed and maintained insulation system. In refrigeration plants a heat flow will occur from the warm outside towards the cold inside. Hot air, containing more moisture, will be distributed to the cold components of the installation, such as separators, intermediate coolers, piping and valves, thus not only facilitating CUI, but also seriously compromising the thermal performance of the system. Furthermore, this moisture could condensate or freeze and compromise the integrity of the installation. Insulation in cold systems is built up with closed cell materials, such as elastomeric foam, PIR (polyisocyanurate) or cellular glass. On the outside a vapor barrier (e.g. reinforced aluminium foil) is essential to prevent hot moist air from penetrating the system. For protection against weather influences and/or mechanical damage, the system should be finished with a (non)metal cladding. [Dutch] Corrosie onder isolatie (CUI) kan worden beperkt door toepassing van een correct ontworpen, geinstalleerd en onderhouden isolatiesysteem. Bij koude-isolatiesystemen treedt een warmtestroom van buiten naar binnen op. Warme lucht - die meer vocht bevat - dringt naar installatiecomponenten, zoals afscheiders, tussenkoelers, leidingen en afstuiters, waarbij niet alleen het risico op CUI aanzienlijk toeneemt, maar ook de isolatiewaarde van het systeem gereduceerd wordt. Vocht kan hierbij ook nog condenseren of bevriezen en de integriteit van de hele installatie in gevaar brengen. Koude-isolatiesystemen dienen te worden opgebouwd met gesloten cel-materiaal, zoals elastomeer schuim, PIR (polyisocyanurate) of cellulair glas. Het systeem dient aan de buitenzijde te worden voorzien van een dampremmende laag (van bijvoorbeeld versterkt aluminiumfolie) om binnendringend vocht te blokkeren. In buitencondities moet het systeem worden voorzien van een (metalen of niet-metalen) eindafwerking, die

  9. Open Content in Open Context

    Science.gov (United States)

    Kansa, Sarah Whitcher; Kansa, Eric C.

    2007-01-01

    This article presents the challenges and rewards of sharing research content through a discussion of Open Context, a new open access data publication system for field sciences and museum collections. Open Context is the first data repository of its kind, allowing self-publication of research data, community commentary through tagging, and clear…

  10. Weak openness and almost openness

    Directory of Open Access Journals (Sweden)

    David A. Rose

    1984-01-01

    Full Text Available Weak openness and almost openness for arbitrary functions between topological spaces are defined as duals to the weak continuity of Levine and the almost continuity of Husain respectively. Independence of these two openness conditions is noted and comparison is made between these and the almost openness of Singal and Singal. Some results dual to those known for weak continuity and almost continuity are obtained. Nearly almost openness is defined and used to obtain an improved link from weak continuity to almost continuity.

  11. Discovery Mondays: Zoom on materials

    CERN Multimedia

    2003-01-01

    Following the success of the first Discovery Monday, which had over 100 visitors, the series of evening events in Microcosm continues. On Monday 2nd June, discover the world of materials. Find out how CERN scientists examine, manufacture and study different materials, at different scales. Did you know for example that using electrons you can observe a hair at a scale equivalent to looking at a boat with the naked eye? Also, that using ultrasound, you can measure the thickness of an object that is completely inaccessible? Find out more about these techniques, and also the high-tech machining and soldering that is carried out in CERN's central workshop. Plus, see how engineers can detect tiny leaks through solder points - essential for maintaining the vacuum in the LHC. The evening is open to all, without reservation, suggested age 12 and above. Rendez-vous in Microcosm on Monday 2nd June From 19.30 - 21.00 Free entry For more information : http://www.cern.ch/microcosm Using a scanning microscope, the head o...

  12. Social Role Discovery in Human Events (Open Access)

    Science.gov (United States)

    2013-10-03

    to all people in the videos. We also present a novel YouTube social roles dataset with ground truth role annota- tions, and introduce annotations on a... nursing home [13], making role identifi- cation a difficult human task. Ideally, we would like to auto- matically discover such interaction-based role...34# $% &’$( ! Figure 2. Sample frames from different events in the YouTube Social

  13. 14 CFR 406.143 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

  14. A Comparative Study of Two Different Uncinectomy Techniques: Swing-Door and Classical

    Directory of Open Access Journals (Sweden)

    Ankit A Singhania

    2011-01-01

    Full Text Available Introduction: The aim of this study was to determine which technique of uncinectomy, classical or swing door technique.  Materials and Methods: Four hundred eighty Cases of sinusitis were selected and operated for Functional Endoscopic Sinus Surgery (FESS. Out of these, in 240 uncinectomies classical uncinectomy was done whereas in another 240 uncinectomies swing door technique was used. Initially patients were medically managed treated according to their symptoms and prior management. Patients who had received previous adequate medical management were evaluated with CT scan of the sinuses. If disease still persists than they were operated for FESS. Results: The authors' experience indicates that Functional endoscopic sinus surgery can be performed under local or general anesthesia, as permitted or tolerated. In this review classical technique was used in 240 uncinectomies. Out of this, ethmoidal complex injury was noted in 4 cases, missed maxillary ostium syndrome (incomplete removal was reported in 12 patients and orbital fat exposure was encountered in 5 patients. As compared to 240 uncinectomies done with swing door technique, incomplete removal was evident in 2 cases and lacrimal duct injury was reported in 3 cases. 'Evidence that underscores how this 'swing door technique' successfully combines 'the conservation goals of the anterior-to-posterior approach and anatomic virtues of the posterior-to-anterior approach to ethmoidectomy of the total 480 uncinectomies operated. Out of which 240 uncinectomies have been performed using the 'swing-door' technique. The 240 uncinectomies performed using classical technique were used as controls. The incidence of orbital penetration, incomplete removal, ethmoidal complex injury and ostium non-identification was significantly less with the new technique. Three lacrimal injuries occurred with the 'swing-door' technique compared to no injuries with classical technique. Conclusion: The authors recommend

  15. A comparative study of two different uncinectomy techniques: swing-door and classical.

    Science.gov (United States)

    Singhania, Ankit A; Bansal, Chetan; Chauhan, Nirali; Soni, Saurav

    2012-01-01

    The aim of this study was to determine which technique of uncinectomy, classical or swing door technique. Four hundred eighty Cases of sinusitis were selected and operated for Functional Endoscopic Sinus Surgery (FESS). Out of these, in 240 uncinectomies classical uncinectomy was done whereas in another 240 uncinectomies swing door technique was used. Initially patients were medically managed treated according to their symptoms and prior management. Patients who had received previous adequate medical management were evaluated with CT scan of the sinuses. If disease still persists than they were operated for FESS. The authors' experience indicates that Functional endoscopic sinus surgery can be performed under local or general anesthesia, as permitted or tolerated. In this review classical technique was used in 240 uncinectomies. Out of this, ethmoidal complex injury was noted in 4 cases, missed maxillary ostium syndrome (incomplete removal) was reported in 12 patients and orbital fat exposure was encountered in 5 patients. As compared to 240 uncinectomies done with swing door technique, incomplete removal was evident in 2 cases and lacrimal duct injury was reported in 3 cases. 'Evidence that underscores how this 'swing door technique' successfully combines 'the conservation goals of the anterior-to-posterior approach and anatomic virtues of the posterior-to-anterior approach to ethmoidectomy of the total 480 uncinectomies operated. Out of which 240 uncinectomies have been performed using the 'swing-door' technique. The 240 uncinectomies performed using classical technique were used as controls. The incidence of orbital penetration, incomplete removal, ethmoidal complex injury and ostium non-identification was significantly less with the new technique. Three lacrimal injuries occurred with the 'swing-door' technique compared to no injuries with classical technique. The authors recommend swing door technique as it is easy to learn, allows complete removal of the

  16. Four disruptive strategies for removing drug discovery bottlenecks.

    Science.gov (United States)

    Ekins, Sean; Waller, Chris L; Bradley, Mary P; Clark, Alex M; Williams, Antony J

    2013-03-01

    Drug discovery is shifting focus from industry to outside partners and, in the process, creating new bottlenecks. Technologies like high throughput screening (HTS) have moved to a larger number of academic and institutional laboratories in the USA, with little coordination or consideration of the outputs and creating a translational gap. Although there have been collaborative public-private partnerships in Europe to share pharmaceutical data, the USA has seemingly lagged behind and this may hold it back. Sharing precompetitive data and models may accelerate discovery across the board, while finding the best collaborators, mining social media and mobile approaches to open drug discovery should be evaluated in our efforts to remove drug discovery bottlenecks. We describe four strategies to rectify the current unsustainable situation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Open Day at the World Trade Organization

    CERN Multimedia

    2009-01-01

    On Sunday 6 September, the World Trade Organization will open its doors to the public. Throughout the day there will be guided tours of the building, which will reveal the many works of art donated by countries over the years; on the main terrace, food stands will give visitors a flavour of the worldwide membership of the WTO and provide the opportunity to sample regional specialities; and children can have fun with face painting, a bouncy castle and a drawing contest on the theme "Draw me globalization" and/or "Draw me the WTO". The full programme of activities

  18. International Drug Discovery Science and Technology--BIT's Seventh Annual Congress.

    Science.gov (United States)

    Bodovitz, Steven

    2010-01-01

    BIT's Seventh Annual International Drug Discovery Science and Technology Congress, held in Shanghai, included topics covering new therapeutic and technological developments in the field of drug discovery. This conference report highlights selected presentations on open-access approaches to R&D, novel and multifactorial targets, and technologies that assist drug discovery. Investigational drugs discussed include the anticancer agents astuprotimut-r (GlaxoSmithKline plc) and AS-1411 (Antisoma plc).

  19. Causality discovery technology

    Science.gov (United States)

    Chen, M.; Ertl, T.; Jirotka, M.; Trefethen, A.; Schmidt, A.; Coecke, B.; Bañares-Alcántara, R.

    2012-11-01

    Causality is the fabric of our dynamic world. We all make frequent attempts to reason causation relationships of everyday events (e.g., what was the cause of my headache, or what has upset Alice?). We attempt to manage causality all the time through planning and scheduling. The greatest scientific discoveries are usually about causality (e.g., Newton found the cause for an apple to fall, and Darwin discovered natural selection). Meanwhile, we continue to seek a comprehensive understanding about the causes of numerous complex phenomena, such as social divisions, economic crisis, global warming, home-grown terrorism, etc. Humans analyse and reason causality based on observation, experimentation and acquired a priori knowledge. Today's technologies enable us to make observations and carry out experiments in an unprecedented scale that has created data mountains everywhere. Whereas there are exciting opportunities to discover new causation relationships, there are also unparalleled challenges to benefit from such data mountains. In this article, we present a case for developing a new piece of ICT, called Causality Discovery Technology. We reason about the necessity, feasibility and potential impact of such a technology.

  20. Automated Supernova Discovery (Abstract)

    Science.gov (United States)

    Post, R. S.

    2015-12-01

    (Abstract only) We are developing a system of robotic telescopes for automatic recognition of Supernovas as well as other transient events in collaboration with the Puckett Supernova Search Team. At the SAS2014 meeting, the discovery program, SNARE, was first described. Since then, it has been continuously improved to handle searches under a wide variety of atmospheric conditions. Currently, two telescopes are used to build a reference library while searching for PSN with a partial library. Since data is taken every night without clouds, we must deal with varying atmospheric and high background illumination from the moon. Software is configured to identify a PSN, reshoot for verification with options to change the run plan to acquire photometric or spectrographic data. The telescopes are 24-inch CDK24, with Alta U230 cameras, one in CA and one in NM. Images and run plans are sent between sites so the CA telescope can search while photometry is done in NM. Our goal is to find bright PSNs with magnitude 17.5 or less which is the limit of our planned spectroscopy. We present results from our first automated PSN discoveries and plans for PSN data acquisition.

  1. Open hardware for open science

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Inspired by the open source software movement, the Open Hardware Repository was created to enable hardware developers to share the results of their R&D activities. The recently published CERN Open Hardware Licence offers the legal framework to support this knowledge and technology exchange.   Two years ago, a group of electronics designers led by Javier Serrano, a CERN engineer, working in experimental physics laboratories created the Open Hardware Repository (OHR). This project was initiated in order to facilitate the exchange of hardware designs across the community in line with the ideals of “open science”. The main objectives include avoiding duplication of effort by sharing results across different teams that might be working on the same need. “For hardware developers, the advantages of open hardware are numerous. For example, it is a great learning tool for technologies some developers would not otherwise master, and it avoids unnecessary work if someone ha...

  2. Open chemistry registry and mapping platform based on open source cheminformatics toolkits (ACS Fall meeting)

    Science.gov (United States)

    TheOpen PHACTS project (openphacts.org) is a European initiative, constituting a public–private partnership to enable easier, cheaper and faster drug discovery [1]. The project is supported by the Open PHACTS Foundation (www.openphactsfoundation.org) and funded by contributions f...

  3. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  4. Open innovation

    DEFF Research Database (Denmark)

    Bogers, Marcel; Chesbrough, Henry; Moedas, Carlos

    2018-01-01

    Open innovation is now a widely used concept in academia, business, and policy making. This article describes the state of open innovation at the intersection of research, practice, and policy. It discusses some key trends (e.g., digital transformation), challenges (e.g., uncertainty...

  5. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

    Directory of Open Access Journals (Sweden)

    Nicholas Ekow Thomford

    2018-05-01

    Full Text Available The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of “active compound” has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of ‘organ-on chip’ and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug

  6. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.

    Science.gov (United States)

    Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred; Dzobo, Kevin

    2018-05-25

    The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of "active compound" has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of 'organ-on chip' and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug development. This review

  7. Ultrasonic Attenuation in clay refectories | Nyongesa | Discovery and ...

    African Journals Online (AJOL)

    Discovery and Innovation. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 13, No 1 (2001) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. DOWNLOAD FULL TEXT Open Access DOWNLOAD FULL TEXT ...

  8. Prototyping Service Discovery and Usage in Wireless Sensor Networks

    NARCIS (Netherlands)

    Marin Perianu, Raluca; Scholten, Johan; Havinga, Paul J.M.

    2007-01-01

    Heterogeneous Wireless Sensor Networks (WSNs) are envisioned to provide different types of services in an open and dynamic environment. This paper presents the design, implementation and evaluation of a service discovery and usage solution for heterogeneous WSNs. The users have the possibility to

  9. Improving Data Discovery, Access, and Analysis to More Than Three Decades of Oceanographic and Geomorphologic Observations

    Science.gov (United States)

    Forte, M.; Hesser, T.; Knee, K.; Ingram, I.; Hathaway, K. K.; Brodie, K. L.; Spore, N.; Bird, A.; Fratantonio, R.; Dopsovic, R.; Keith, A.; Gadomski, K.

    2016-02-01

    The U.S. Army Engineer Research and Development Center's (USACE ERDC) Coastal and Hydraulics Laboratory (CHL) Coastal Observations and Analysis Branch (COAB) Measurements Program has a 35-year record of coastal observations. These datasets include oceanographic point source measurements, Real-Time Kinematic (RTK) GPS bathymetry surveys, and remote sensing data from both the Field Research Facility (FRF) in Duck, NC and from other project and experiment sites around the nation. The data has been used to support a variety of USACE mission areas, including coastal wave model development, beach and bar response, coastal project design, coastal storm surge, and other coastal hazard investigations. Furthermore these data have been widely used by a number of federal and state agencies, academic institutions, and private industries in hundreds of scientific and engineering investigations, publications, conference presentations and model advancement studies. A limiting factor to the use of FRF data has been rapid, reliable access and publicly available metadata for each data type. The addition of web tools, accessible data files, and well-documented metadata will open the door to much future collaboration. With the help of industry partner RPS ASA and the U.S. Army Corps of Engineers Mobile District Spatial Data Branch, a Data Integration Framework (DIF) was developed. The DIF represents a combination of processes, standards, people, and tools used to transform disconnected enterprise data into useful, easily accessible information for analysis and reporting. A front-end data portal connects the user to the framework that integrates both oceanographic observation and geomorphology measurements using a combination of ESRI and open-source technology while providing a seamless data discovery, access, and analysis experience to the user. The user interface was built with ESRI's JavaScript API and all project metadata is managed using Geoportal. The geomorphology data is made

  10. Computational methods in drug discovery

    OpenAIRE

    Sumudu P. Leelananda; Steffen Lindert

    2016-01-01

    The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery project...

  11. Representation Discovery using Harmonic Analysis

    CERN Document Server

    Mahadevan, Sridhar

    2008-01-01

    Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu

  12. Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR).

    Science.gov (United States)

    Evans, Scott R; Rubin, Daniel; Follmann, Dean; Pennello, Gene; Huskins, W Charles; Powers, John H; Schoenfeld, David; Chuang-Stein, Christy; Cosgrove, Sara E; Fowler, Vance G; Lautenbach, Ebbing; Chambers, Henry F

    2015-09-01

    Clinical trials that compare strategies to optimize antibiotic use are of critical importance but are limited by competing risks that distort outcome interpretation, complexities of noninferiority trials, large sample sizes, and inadequate evaluation of benefits and harms at the patient level. The Antibacterial Resistance Leadership Group strives to overcome these challenges through innovative trial design. Response adjusted for duration of antibiotic risk (RADAR) is a novel methodology utilizing a superiority design and a 2-step process: (1) categorizing patients into an overall clinical outcome (based on benefits and harms), and (2) ranking patients with respect to a desirability of outcome ranking (DOOR). DOORs are constructed by assigning higher ranks to patients with (1) better overall clinical outcomes and (2) shorter durations of antibiotic use for similar overall clinical outcomes. DOOR distributions are compared between antibiotic use strategies. The probability that a randomly selected patient will have a better DOOR if assigned to the new strategy is estimated. DOOR/RADAR represents a new paradigm in assessing the risks and benefits of new strategies to optimize antibiotic use. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. DYNAMIC TIME HISTORY ANALYSIS OF BLAST RESISTANT DOOR USING BLAST LOAD MODELED AS IMPACT LOAD

    Directory of Open Access Journals (Sweden)

    Y. A. Pranata

    2012-06-01

    Full Text Available A blast resistant single door was designed to withstand a 0.91 bar blast pressure and 44 ms blast duration. The analysis was done using Dynamic Time History Analysis using Blast Load modeled as Impact Load for given duration. The material properties used have been modified to accommodate dynamic effects. The analysis was done using dynamic finite element method (fem for time of the blast duration, and the maximum/minimum internal forces and displacement were taken from the time history output, in order to know the behavior under blast load and estimate the safety margin of the door. Results obtained from this research indicated that the maximum z-displacement is 1.709 mm, while in the term of serviceability, the permitted is 25 mm. The maximum reaction force is 73,960 N, while the maximum anchor capacity is 82,069 N. On blast condition, the maximum frame stress is 71.71 MPa, the maximum hinge shear stress is 45.28 MPa. While on rebound condition, the maximum frame stress is 172.11 MPa, the maximum hinge shear stress is 29.46 MPa. The maximum door edge rotation is 0.44 degree, which is not exceed the permitted boundary (1.2 degree. Keywords: Dynamic time history, blast resistant door, single door, finite element method.

  14. Barriers to and enablers for European rail freight transport for integrated door-to-door logistics service. Part 2: Enablers for multimodal rail freight transport

    Directory of Open Access Journals (Sweden)

    Dewan Md Zahurul ISLAM

    2014-12-01

    Full Text Available The objective of this paper is to examine and identify barriers to and enablers for the European rail freight transport services as a transport chain partner along the supply chains in the changing market scenario. The changing market scenario includes, among others, requiring 'door-to-door' rather than 'terminal to terminal' and integrated service, competitive ability to attract non-rail cargo type, changes in the customer requirements (e.g. reliable service and changes in the operational requirements and practices. Using a literature review method, the paper is presented in two parts. The part 1 focuses on the identification of barriers to the European rail freight service by reviewing freight logistics services for global supply chains followed by the current performance of European rail freight transport followed by a discussion on the rail freight market liberalisation in Europe. Then rail freight transport in the Unites States (U.S. is discussed. The research notes that although the background, scope and necessity for reform measures in Europe differ from those of the U.S., some lessons can be learned and the main lesson is that an appropriate reform measure can enhance rail sector competitive ability in Europe. The part 2 of the paper is dedicated to recommend some concrete steps and actions as enablers to remove the barriers identified in the part 1 to develop multimodal rail freight transport. The enablers for multimodal rail freight transport include: •\tEuropean rail freight transport market needs full liberalisation so that incumbent and new entrants can compete freely. •\tThe rail operators need to acquire service (e.g. customer tailored services, door to door service quality offered by road freight operators. •\tThey need to conduct a combination of ‘terminal-to-terminal’ and door-to-door operations, as and when needed; •\tThey must build partnership with freight forwarder or 3PLs to include all types of customers

  15. Hippocampus discovery First steps

    Directory of Open Access Journals (Sweden)

    Eliasz Engelhardt

    Full Text Available The first steps of the discovery, and the main discoverers, of the hippocampus are outlined. Arantius was the first to describe a structure he named "hippocampus" or "white silkworm". Despite numerous controversies and alternate designations, the term hippocampus has prevailed until this day as the most widely used term. Duvernoy provided an illustration of the hippocampus and surrounding structures, considered the first by most authors, which appeared more than one and a half century after Arantius' description. Some authors have identified other drawings and texts which they claim predate Duvernoy's depiction, in studies by Vesalius, Varolio, Willis, and Eustachio, albeit unconvincingly. Considering the definition of the hippocampal formation as comprising the hippocampus proper, dentate gyrus and subiculum, Arantius and Duvernoy apparently described the gross anatomy of this complex. The pioneering studies of Arantius and Duvernoy revealed a relatively small hidden formation that would become one of the most valued brain structures.

  16. Technology-Enhanced Discovery

    Science.gov (United States)

    Harrow, Chris; Chin, Lillian

    2014-01-01

    Exploration, innovation, proof: For students, teachers, and others who are curious, keeping an open mind and being ready to investigate unusual or unexpected properties will always lead to learning something new. Technology can further this process, allowing various behaviors to be analyzed that were previously memorized or poorly understood. This…

  17. A journey of discovery

    Indian Academy of Sciences (India)

    Lawrence

    Even later , being mostly self-driven has helped me treat any obstacle in my career as a temporary problem. Doing a Ph.D. in the United States, brought new oppor- tunities and encouraged an openness to things, and most impor- tantly the necessity of steady, dedicated, hard work for a scientist. There, I also met Aloke Jain, ...

  18. O triste quadro da saúde: análise de um out-door

    Directory of Open Access Journals (Sweden)

    Fernando Lefèvre

    1995-09-01

    Full Text Available Procura-se, neste trabalho, analisar um out­door presente na cidade de São Paulo, no mês de maio de 1993, e que intitula-se : "O triste quadro da saúde". Em função de vários elementos encontrados no texto e em função do contexto externo, o referido out-door permite e possibilita, pelo menos, duas leituras de sentidos absolutamente opostos, o que, certamente, implica, no caso de um out-door "assinado", uma escolha inadequada da mensagem por parte dos signatários. Em função disso, sugere-se cuidado e atenção para a ambigüidade presente, com muita freqüência, nas mensagens e nos discursos.

  19. DOORS syndrome: phenotype, genotype and comparison with Coffin-Siris syndrome.

    Science.gov (United States)

    Campeau, Philippe M; Hennekam, Raoul C

    2014-09-01

    DOORS syndrome (Deafness, Onychodystrophy, Osteodystrophy, mental Retardation, Seizures) is characterized mainly by sensorineural deafness, shortened terminal phalanges with small nails of hands and feet, intellectual deficiency, and seizures. Half of the patients with all clinical features have mutations in TBC1D24. We review here the manifestations of patients clinically diagnosed with DOORS syndrome. In this cohort of 32 families (36 patients) we detected 13 individuals from 10 families with TBC1D24 mutations. Subsequent whole exome sequencing in the cohort showed the same de novoSMARCB1 mutation (c.1130G>A), known to cause Coffin-Siris syndrome, in two patients. Distinguishing features include retinal anomalies, Dandy-Walker malformation, scoliosis, rocker bottom feet, respiratory difficulties and absence of seizures, and 2-oxoglutaric aciduria in the patients with the SMARCB1 mutation. We briefly discuss the heterogeneity of the DOORS syndrome phenotype and the differential diagnosis of this condition. © 2014 Wiley Periodicals, Inc.

  20. Open Bibliography

    OpenAIRE

    Murray-Rust, Peter; Pollock, Rufus; MacGillivray, Mark; O'Steen, Ben; Waites, William

    2011-01-01

    Poster presented at the VSMF Symposium held at the Unilever Centre on 2011-01-17. More research is published currently than can be understood or followed by a researcher without the aid of a computer. We need Open shareable information on research publications, an Open Bibliography, to build the services that enable researchers to explore their field and discover the research they need. Producers of bibliographic data such as libraries, publishers, universities, scholars or social referenc...

  1. Open IS

    DEFF Research Database (Denmark)

    Germonprez, Matt; Crowston, Kevin; Avital, Michel

    2013-01-01

    The collective intelligence and collective action of “open” communities have produced a variety of complex knowledge goods and radical social change. The Information Systems (IS) community has invested significant effort into researching open communities and the ecosystems in which they operate...... therefore seeks to stimulate a thoughtful and dynamic discussion around the proposition that becoming a more open community will enhance the IS discipline’s scholarly inquiry and global impact....

  2. Indoor Modelling from Slam-Based Laser Scanner: Door Detection to Envelope Reconstruction

    Science.gov (United States)

    Díaz-Vilariño, L.; Verbree, E.; Zlatanova, S.; Diakité, A.

    2017-09-01

    Updated and detailed indoor models are being increasingly demanded for various applications such as emergency management or navigational assistance. The consolidation of new portable and mobile acquisition systems has led to a higher availability of 3D point cloud data from indoors. In this work, we explore the combined use of point clouds and trajectories from SLAM-based laser scanner to automate the reconstruction of building indoors. The methodology starts by door detection, since doors represent transitions from one indoor space to other, which constitutes an initial approach about the global configuration of the point cloud into building rooms. For this purpose, the trajectory is used to create a vertical point cloud profile in which doors are detected as local minimum of vertical distances. As point cloud and trajectory are related by time stamp, this feature is used to subdivide the point cloud into subspaces according to the location of the doors. The correspondence between subspaces and building rooms is not unambiguous. One subspace always corresponds to one room, but one room is not necessarily depicted by just one subspace, for example, in case of a room containing several doors and in which the acquisition is performed in a discontinue way. The labelling problem is formulated as combinatorial approach solved as a minimum energy optimization. Once the point cloud is subdivided into building rooms, envelop (conformed by walls, ceilings and floors) is reconstructed for each space. The connectivity between spaces is included by adding the previously detected doors to the reconstructed model. The methodology is tested in a real case study.

  3. INDOOR MODELLING FROM SLAM-BASED LASER SCANNER: DOOR DETECTION TO ENVELOPE RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    L. Díaz-Vilariño

    2017-09-01

    Full Text Available Updated and detailed indoor models are being increasingly demanded for various applications such as emergency management or navigational assistance. The consolidation of new portable and mobile acquisition systems has led to a higher availability of 3D point cloud data from indoors. In this work, we explore the combined use of point clouds and trajectories from SLAM-based laser scanner to automate the reconstruction of building indoors. The methodology starts by door detection, since doors represent transitions from one indoor space to other, which constitutes an initial approach about the global configuration of the point cloud into building rooms. For this purpose, the trajectory is used to create a vertical point cloud profile in which doors are detected as local minimum of vertical distances. As point cloud and trajectory are related by time stamp, this feature is used to subdivide the point cloud into subspaces according to the location of the doors. The correspondence between subspaces and building rooms is not unambiguous. One subspace always corresponds to one room, but one room is not necessarily depicted by just one subspace, for example, in case of a room containing several doors and in which the acquisition is performed in a discontinue way. The labelling problem is formulated as combinatorial approach solved as a minimum energy optimization. Once the point cloud is subdivided into building rooms, envelop (conformed by walls, ceilings and floors is reconstructed for each space. The connectivity between spaces is included by adding the previously detected doors to the reconstructed model. The methodology is tested in a real case study.

  4. Gallbladder removal - open

    Science.gov (United States)

    Cholecystectomy - open; Gallbladder - open cholecystectomy; Cholecystitis - open cholecystectomy; Gallstones - open cholecystectomy ... a medical instrument called a laparoscope ( laparoscopic ... Open gallbladder surgery is used when laparoscopic surgery cannot ...

  5. Materials Discovery | Materials Science | NREL

    Science.gov (United States)

    Discovery Materials Discovery Images of red and yellow particles NREL's research in materials characterization of sample by incoming beam and measuring outgoing particles, with data being stored and analyzed Staff Scientist Dr. Zakutayev specializes in design of novel semiconductor materials for energy

  6. Service discovery using Bloom filters

    NARCIS (Netherlands)

    Goering, P.T.H.; Heijenk, Geert; Lelieveldt, B.P.F.; Haverkort, Boudewijn R.H.M.; de Laat, C.T.A.M.; Heijnsdijk, J.W.J.

    A protocol to perform service discovery in adhoc networks is introduced in this paper. Attenuated Bloom filters are used to distribute services to nodes in the neighborhood and thus enable local service discovery. The protocol has been implemented in a discrete event simulator to investigate the

  7. On the pulse of discovery

    Science.gov (United States)

    2017-12-01

    What started 50 years ago as a `smudge' on paper has flourished into a fundamental field of astrophysics replete with unexpected applications and exciting discoveries. To celebrate the discovery of pulsars, we look at the past, present and future of pulsar astrophysics.

  8. Development of the automated bunker door by using a microcontroller-system

    Science.gov (United States)

    Ahmad, M. A.; Leo, K. W.; Mohamad, G. H. P.; Ahmad, A.; Hashim, S. A.; Chulan, R. M.; Baijan, A. H.

    2018-01-01

    The new low energy electron beam accelerator bunker was designed and built locally to allocate a 500 keV electron beam accelerator at Block 43T in Malaysian Nuclear Agency. This bunker is equipped with a locally made radiation shielding door of 10 tons. Originally, this door is moving manually by a wheel and fitted with a gear system. However, it is still heavy and need longer time to operate it manually. To overcome those issues, a new automated control system has been designed and developed. In this paper, the complete steps and design of automated control system based on the microcontroller (PIC16F84A) is described.

  9. An Intelligent Automated Door Control System Based on a Smart Camera

    Directory of Open Access Journals (Sweden)

    Jiann-Jone Chen

    2013-05-01

    Full Text Available This paper presents an innovative access control system, based on human detection and path analysis, to reduce false automatic door system actions while increasing the added values for security applications. The proposed system can first identify a person from the scene, and track his trajectory to predict his intention for accessing the entrance, and finally activate the door accordingly. The experimental results show that the proposed system has the advantages of high precision, safety, reliability, and can be responsive to demands, while preserving the benefits of being low cost and high added value.

  10. 29 CFR 2700.56 - Discovery; general.

    Science.gov (United States)

    2010-07-01

    ...(c) or 111 of the Act has been filed. 30 U.S.C. 815(c) and 821. (e) Completion of discovery... 29 Labor 9 2010-07-01 2010-07-01 false Discovery; general. 2700.56 Section 2700.56 Labor... Hearings § 2700.56 Discovery; general. (a) Discovery methods. Parties may obtain discovery by one or more...

  11. 19 CFR 207.109 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 207.109 Section 207.109 Customs Duties... and Committee Proceedings § 207.109 Discovery. (a) Discovery methods. All parties may obtain discovery under such terms and limitations as the administrative law judge may order. Discovery may be by one or...

  12. 30 CFR 44.24 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Discovery. 44.24 Section 44.24 Mineral... Discovery. Parties shall be governed in their conduct of discovery by appropriate provisions of the Federal... discovery. Alternative periods of time for discovery may be prescribed by the presiding administrative law...

  13. 19 CFR 356.20 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 356.20 Section 356.20 Customs Duties... § 356.20 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery... sanctions proceeding. (b) Limitations on discovery. The administrative law judge shall place such limits...

  14. 24 CFR 180.500 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

  15. 15 CFR 25.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discovery. 25.21 Section 25.21... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...

  16. 39 CFR 963.14 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Discovery. 963.14 Section 963.14 Postal Service... PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.14 Discovery. Discovery is to be conducted on a... such discovery as he or she deems reasonable and necessary. Discovery may include one or more of the...

  17. 22 CFR 224.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  18. Emerging Concepts and Methodologies in Cancer Biomarker Discovery.

    Science.gov (United States)

    Lu, Meixia; Zhang, Jinxiang; Zhang, Lanjing

    2017-01-01

    Cancer biomarker discovery is a critical part of cancer prevention and treatment. Despite the decades of effort, only a small number of cancer biomarkers have been identified for and validated in clinical settings. Conceptual and methodological breakthroughs may help accelerate the discovery of additional cancer biomarkers, particularly their use for diagnostics. In this review, we have attempted to review the emerging concepts in cancer biomarker discovery, including real-world evidence, open access data, and data paucity in rare or uncommon cancers. We have also summarized the recent methodological progress in cancer biomarker discovery, such as high-throughput sequencing, liquid biopsy, big data, artificial intelligence (AI), and deep learning and neural networks. Much attention has been given to the methodological details and comparison of the methodologies. Notably, these concepts and methodologies interact with each other and will likely lead to synergistic effects when carefully combined. Newer, more innovative concepts and methodologies are emerging as the current emerging ones became mainstream and widely applied to the field. Some future challenges are also discussed. This review contributes to the development of future theoretical frameworks and technologies in cancer biomarker discovery and will contribute to the discovery of more useful cancer biomarkers.

  19. A Metadata Schema for Geospatial Resource Discovery Use Cases

    Directory of Open Access Journals (Sweden)

    Darren Hardy

    2014-07-01

    Full Text Available We introduce a metadata schema that focuses on GIS discovery use cases for patrons in a research library setting. Text search, faceted refinement, and spatial search and relevancy are among GeoBlacklight's primary use cases for federated geospatial holdings. The schema supports a variety of GIS data types and enables contextual, collection-oriented discovery applications as well as traditional portal applications. One key limitation of GIS resource discovery is the general lack of normative metadata practices, which has led to a proliferation of metadata schemas and duplicate records. The ISO 19115/19139 and FGDC standards specify metadata formats, but are intricate, lengthy, and not focused on discovery. Moreover, they require sophisticated authoring environments and cataloging expertise. Geographic metadata standards target preservation and quality measure use cases, but they do not provide for simple inter-institutional sharing of metadata for discovery use cases. To this end, our schema reuses elements from Dublin Core and GeoRSS to leverage their normative semantics, community best practices, open-source software implementations, and extensive examples already deployed in discovery contexts such as web search and mapping. Finally, we discuss a Solr implementation of the schema using a "geo" extension to MODS.

  20. Open access

    CERN Document Server

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder consent, and many authors, musicians, filmmakers, and other creators who depend on royalties are understandably unwilling to give their consent. But for 350 years, scholars have written peer-reviewed journal articles for impact, not for money, and are free to consent to open access without losing revenue. In this concise introduction, Peter Suber tells us what open access is and isn't, how it benefits authors and readers of research, how we pay for it, how it avoids copyright problems, how it has moved from the periphery to the mainstream, and what its future may hold. Distilling a decade of Suber's influential writing and thinking about open access, this is the indispe...

  1. Discovery Mondays: Surveyors' Tools

    CERN Multimedia

    2003-01-01

    Surveyors of all ages, have your rulers and compasses at the ready! This sixth edition of Discovery Monday is your chance to learn about the surveyor's tools - the state of the art in measuring instruments - and see for yourself how they work. With their usual daunting precision, the members of CERN's Surveying Group have prepared some demonstrations and exercises for you to try. Find out the techniques for ensuring accelerator alignment and learn about high-tech metrology systems such as deviation indicators, tracking lasers and total stations. The surveyors will show you how they precisely measure magnet positioning, with accuracy of a few thousandths of a millimetre. You can try your hand at precision measurement using different types of sensor and a modern-day version of the Romans' bubble level, accurate to within a thousandth of a millimetre. You will learn that photogrammetry techniques can transform even a simple digital camera into a remarkable measuring instrument. Finally, you will have a chance t...

  2. Open innovation

    DEFF Research Database (Denmark)

    West, Joel; Bogers, Marcel

    2017-01-01

    Interest in open innovation (OI) as a field of research has grown exponentially since the phrase was coined by Chesbrough in his 2003 book, with numerous articles, special issues, books, and conference sessions. Various reviews of the literature have summarized prior work, offered new frameworks......, and identified opportunities for future research. Here we summarize these opportunities, which include more research on outbound OI, the role of open innovation in services, and network forms of collaboration such as consortia, communities, ecosystems, and platforms. Research should also examine the use of OI...... by small, new, and not-for-profit organizations, as well as the linkage of individual actions and motivations to open innovation. Other opportunities include better measuring the costs, benefits, antecedents, mediators and moderators of the effects of OI on performance, and understanding why and how OI...

  3. The 2015 Bioinformatics Open Source Conference (BOSC 2015).

    Science.gov (United States)

    Harris, Nomi L; Cock, Peter J A; Lapp, Hilmar; Chapman, Brad; Davey, Rob; Fields, Christopher; Hokamp, Karsten; Munoz-Torres, Monica

    2016-02-01

    The Bioinformatics Open Source Conference (BOSC) is organized by the Open Bioinformatics Foundation (OBF), a nonprofit group dedicated to promoting the practice and philosophy of open source software development and open science within the biological research community. Since its inception in 2000, BOSC has provided bioinformatics developers with a forum for communicating the results of their latest efforts to the wider research community. BOSC offers a focused environment for developers and users to interact and share ideas about standards; software development practices; practical techniques for solving bioinformatics problems; and approaches that promote open science and sharing of data, results, and software. BOSC is run as a two-day special interest group (SIG) before the annual Intelligent Systems in Molecular Biology (ISMB) conference. BOSC 2015 took place in Dublin, Ireland, and was attended by over 125 people, about half of whom were first-time attendees. Session topics included "Data Science;" "Standards and Interoperability;" "Open Science and Reproducibility;" "Translational Bioinformatics;" "Visualization;" and "Bioinformatics Open Source Project Updates". In addition to two keynote talks and dozens of shorter talks chosen from submitted abstracts, BOSC 2015 included a panel, titled "Open Source, Open Door: Increasing Diversity in the Bioinformatics Open Source Community," that provided an opportunity for open discussion about ways to increase the diversity of participants in BOSC in particular, and in open source bioinformatics in general. The complete program of BOSC 2015 is available online at http://www.open-bio.org/wiki/BOSC_2015_Schedule.

  4. Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.

    Science.gov (United States)

    Benson, Neil

    2015-08-01

    Phase II attrition remains the most important challenge for drug discovery. Tackling the problem requires improved understanding of the complexity of disease biology. Systems biology approaches to this problem can, in principle, deliver this. This article reviews the reports of the application of mechanistic systems models to drug discovery questions and discusses the added value. Although we are on the journey to the virtual human, the length, path and rate of learning from this remain an open question. Success will be dependent on the will to invest and make the most of the insight generated along the way. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Open Education and the Open Science Economy

    Science.gov (United States)

    Peters, Michael A.

    2009-01-01

    Openness as a complex code word for a variety of digital trends and movements has emerged as an alternative mode of "social production" based on the growing and overlapping complexities of open source, open access, open archiving, open publishing, and open science. This paper argues that the openness movement with its reinforcing structure of…

  6. Door-to-needle time for administration of fibrinolytics in acute ...

    African Journals Online (AJOL)

    Objectives. To determine the current door-to-needle time for the administration of fibrinolytics for acute myocardial infarction (AMI) in emergency centres (ECs) at three hospitals in Cape Town, and to compare it with the American Heart Association/American College of Cardiology (AHA/ACC) recommendation of 30 minutes ...

  7. Online uitlenen van e-books door bibliotheken: verkenning juridische mogelijkheden en economische effecten

    NARCIS (Netherlands)

    van der Noll, R.; Breemen, K.; Breemen, V.; Hugenholtz, B.; Brom, M.; Poort, J.

    2012-01-01

    Het uitlenen van e-books door openbare bibliotheken is in een groeiend aantal landen een realiteit. Dit rapport inventariseert deze praktijk en analyseert de juridische mogelijkheden voor en economische gevolgen van e-lending. In het economische deel van deze verkenning wordt onderzocht in welke

  8. The genetic basis of DOORS syndrome: an exome-sequencing study

    NARCIS (Netherlands)

    Campeau, Philippe M.; Kasperaviciute, Dalia; Lu, James T.; Burrage, Lindsay C.; Kim, Choel; Hori, Mutsuki; Powell, Berkley R.; Stewart, Fiona; Félix, Têmis Maria; van den Ende, Jenneke; Wisniewska, Marzena; Kayserili, Hülya; Rump, Patrick; Nampoothiri, Sheela; Aftimos, Salim; Mey, Antje; Nair, Lal D. V.; Begleiter, Michael L.; de Bie, Isabelle; Meenakshi, Girish; Murray, Mitzi L.; Repetto, Gabriela M.; Golabi, Mahin; Blair, Edward; Male, Alison; Giuliano, Fabienne; Kariminejad, Ariana; Newman, William G.; Bhaskar, Sanjeev S.; Dickerson, Jonathan E.; Kerr, Bronwyn; Banka, Siddharth; Giltay, Jacques C.; Wieczorek, Dagmar; Tostevin, Anna; Wiszniewska, Joanna; Cheung, Sau Wai; Hennekam, Raoul C.; Gibbs, Richard A.; Lee, Brendan H.; Sisodiya, Sanjay M.

    2014-01-01

    Deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures (DOORS) syndrome is a rare autosomal recessive disorder of unknown cause. We aimed to identify the genetic basis of this syndrome by sequencing most coding exons in affected individuals. Through a search of available case

  9. The genetic basis of DOORS syndrome : an exome-sequencing study

    NARCIS (Netherlands)

    Campeau, Philippe M.; Kasperaviciute, Dalia; Lu, James T.; Burrage, Lindsay C.; Kim, Choel; Hori, Mutsuki; Powell, Berkley R.; Stewart, Fiona; Felix, Temis Maria; van den Ende, Jenneke; Wisniewska, Marzena; Kayserili, Huelya; Rump, Patrick; Nampoothiri, Sheela; Aftimos, Salim; Mey, Antje; Nair, Lal D. V.; Begleiter, Michael L.; De Bie, Isabelle; Meenakshi, Girish; Murray, Mitzi L.; Repetto, Gabriela M.; Golabi, Mahin; Blair, Edward; Male, Alison; Giuliano, Fabienne; Kariminejad, Ariana; Newman, William G.; Bhaskar, Sanjeev S.; Dickerson, Jonathan E.; Kerr, Bronwyn; Banka, Siddharth; Giltay, Jacques C.; Wieczorek, Dagmar; Tostevin, Anna; Wiszniewska, Joanna; Cheung, Sau Wai; Hennekam, Raoul C.; Gibbs, Richard A.; Lee, Brendan H.; Sisodiya, Sanjay M.

    Background Deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures (DOORS) syndrome is a rare autosomal recessive disorder of unknown cause. We aimed to identify the genetic basis of this syndrome by sequencing most coding exons in affected individuals. Methods Through a search

  10. Diepe grondwatervervuiling door een bouwlandperceel in de 10-jaarszone van waterwingebied Putten

    NARCIS (Netherlands)

    Krajenbrink GJW

    1988-01-01

    In het kader van het stikstofproject heeft het RIVM onderzoek verricht naar de grondwaterverontreiniging tot max. 70 meter diepte onder- en benedenstrooms van een bouwlandperceel, omgeven door bos. Het water in de 180 meter dikke grofzandige freatische aquifer is gedetailleerd bemonsterd met

  11. 40 CFR 63.305 - Alternative standards for coke oven doors equipped with sheds.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Alternative standards for coke oven doors equipped with sheds. 63.305 Section 63.305 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES National Emission Standards for Coke Oven Batteries § 63.305 Alternative standards for...

  12. Financiële verslaggeving door het Rijk vergeleken met IPSAS

    NARCIS (Netherlands)

    van Schaik, F.

    2014-01-01

    De Europese Commissie bereidt plannen voor om de financiële verslaggeving door de overheden van de lidstaten te harmoniseren met als doel een verbetering van transparantie en vergelijkbaarheid. De Europese schuldencrisis heeft duidelijk gemaakt dat de jaarrekeningen van de overheden van de lidstaten

  13. Modus operandi onderzoek naar door informatie en communicatie technologie (ICT) gefaciliteerde criminaliteit

    NARCIS (Netherlands)

    Junger, Marianne; Montoya, L.; Hartel, Pieter H.; Karemaker, M.

    Dit onderzoek beschrijft de invloed van ICT op de 'traditionele' misdrijven door te onderzoeken hoe delicten als inbraak, overvallen en fraude doordrongen zijn van ICT. In totaal zijn 136 woninginbraken, 140 commerciële inbraken, 259 bedreigingen en 274 fraudeza-ken onderzocht. Uit de resultaten

  14. Scheduling Trucks in a Cross-Dock with Mixed Service Mode Dock Doors

    DEFF Research Database (Denmark)

    Bodnar, Peter; Azadeh, Kaveh; Koster, René de

    2017-01-01

    The problem considered in this paper is how to schedule inbound and outbound trucks subject to time windows at a multidoor cross-dock. Dock doors can either be dedicated to inbound or outbound trucks or be capable of handling both truck types. In addition, loads are allowed to be temporarily...

  15. Leren bedrijfseconomische problemen op te lossen door het maken van vakspecifieke schema’s

    NARCIS (Netherlands)

    Slof, Bert; Erkens, Gijsbert; Kirschner, Paul A.

    2010-01-01

    Slof, B., Erkens, G., & Kirschner, P. A. (2010). Leren bedrijfseconomische problemen op te lossen door het maken van vakspecifieke schema’s [Learning to solve business-economics problems through constructing domainspecific diagrams]. Tijdschrift voor het Economisch Onderwijs (TEO), 110(4), 226–230.

  16. 30 CFR 57.8531 - Construction and maintenance of ventilation doors.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Construction and maintenance of ventilation... NONMETAL MINES Ventilation Underground Only § 57.8531 Construction and maintenance of ventilation doors... constructed of wood; (c) Maintained in good condition; (d) Self-closing, if manually operated; and (e...

  17. Effectieve kolonisatie van aardappelplanten door Dickeya-soorten (Erwinia chrysanthemi) : themanummer fytobacteriologie

    NARCIS (Netherlands)

    Wolf, van der J.M.; Czajkowski, R.L.; Velvis, H.

    2009-01-01

    De bacterieziekten zwartbenigheid en stengelnatrot, veroorzaakt door Pectobacterium en Dickeya (Erwinia)- soorten, berokkenen grote schade aan de pootaardappelteelt. Bij PRI en HZPC wordt onderzoek verricht naar de verspreiding van deze pathogenen tijdens teelt- en (na)oogst. Het was al bekend dat

  18. Bodemverontreiniging en de opname van lood in moestuingewassen : Risico's van lood door bodemverontreiniging

    NARCIS (Netherlands)

    Otte PF; Romkens PFAM; Rietra RPJJ; Lijzen JPA; LER; mev

    2012-01-01

    Lood uit bodemverontreinigingen wordt opgenomen door moestuingewassen die daarop worden geteeld. Deze gewassen kunnen een gezondheidsrisico vormen als zij worden geconsumeerd. Uit onderzoek van RIVM en Alterra blijkt nu dat bij hoge concentraties lood in de bodem de opname minder wordt. Hierdoor

  19. 3D Modeling of Building Indoor Spaces and Closed Doors from Imagery and Point Clouds

    Directory of Open Access Journals (Sweden)

    Lucía Díaz-Vilariño

    2015-02-01

    Full Text Available 3D models of indoor environments are increasingly gaining importance due to the wide range of applications to which they can be subjected: from redesign and visualization to monitoring and simulation. These models usually exist only for newly constructed buildings; therefore, the development of automatic approaches for reconstructing 3D indoors from imagery and/or point clouds can make the process easier, faster and cheaper. Among the constructive elements defining a building interior, doors are very common elements and their detection can be very useful either for knowing the environment structure, to perform an efficient navigation or to plan appropriate evacuation routes. The fact that doors are topologically connected to walls by being coplanar, together with the unavoidable presence of clutter and occlusions indoors, increases the inherent complexity of the automation of the recognition process. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors based on point clouds and images. The methodology analyses the visibility problem of indoor environments and goes in depth with door candidate detection. The presented approach is tested in real data sets showing its potential with a high door detection rate and applicability for robust and efficient envelope reconstruction.

  20. The Romanesque Bronze Doors at Gniezno Cathedral Church: Some New Remarks

    Directory of Open Access Journals (Sweden)

    Tomasz Węcławowicz

    2017-06-01

    Full Text Available Among many Romanesque bronze doors in Europe the old entrance doors of the metropolitan cathedral in Gniezno, in the North Poland, are exceptional. For over a century many historians and historians of art have been trying to understand and explain its iconographic phenomenon. The Polish, Czech and German scholars have so far been unable to identify with any conviction, either the iconographic models or artistic provenance of the workshop. There were suggested some connections of the alleged bishop patrons to France and there were emphasizes technological possibilities of foundry workshops at the Meuse Valley. This “Meuse hypothesis” based mainly on historical suggestions became established as a certainty. However, it is important to emphasize the significant difference between the creator of the composition and of the craftsman who cast the bronze door. Years ago only Lech Kalinowski pointed out some general formal similarities to the North Italian sculpture. The purpose of this paper is to develop Kalinowski’s suggestions and to emphasise the puzzling similarities between details of Gniezno doors and some Emilian works executed by Master Wiligelmo da Modena and Master Nicolò. The concept of Italian relationship from Emilia province seems to be better for the comparative analysis than relationship with Meuse Valley based mostly on historical context. Crucial here is the additional, parallel analysis of the portal decoration in Czerwinsk Abbey.

  1. 30 CFR 77.303 - Hot gas inlet chamber dropout doors.

    Science.gov (United States)

    2010-07-01

    ... Section 77.303 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS OF UNDERGROUND... employ a hot gas inlet chamber shall be equipped with drop-out doors at the bottom of the inlet chamber...

  2. The Glass Door: The Gender Composition of Newly-Hired Workers Across Hierarchical Job Levels

    NARCIS (Netherlands)

    Hassink, W.H.J.|info:eu-repo/dai/nl/090437411; Russo, G.|info:eu-repo/dai/nl/124883206

    This paper examines the gender composition of the flow of new hirees along the organizational hierarchy of jobs. We find that women have a reduced chance to be hired at higher hierarchical levels. We refer to this phenomenon as the “glass door”. The glass door consists of an absolute and a relative

  3. 'The Lusiads', poem of discovery

    Directory of Open Access Journals (Sweden)

    Natasha Furlan Felizi

    2016-07-01

    Full Text Available The article proposes reading Os Lusíadas as a discovery journey. Discovery here read as aletheia or “revelation”, as proposed by Sophia de Mello Brey­ner Andresen in 1980. Using Martin Heidegger’s notion of aletheia in the book Parmenides along with Jorge de Sena and Sophia de Mello Breyner Andresen reflections on Camões, I’ll seek to point out alternative readings for Os Lusíadas as a “discovery journey”.

  4. The Open

    Directory of Open Access Journals (Sweden)

    Saitya Brata Das

    2009-12-01

    Full Text Available In the Open darkness and light, remembrance and oblivion, coming into existence and disappearing in death play their originary co-belonging, or co-figuration. Existence belongs to this opening and is exposed to its coming to presence: it is on the basis of this originary opening, this originary historical which is revealed to this mortal being called ‘man,’ on the basis of this revelation, man founds something like politics and history. There thus comes into existence out of this freedom, out of this “play space”2, this field called ‘polis’3 where there takes place war and festival, where historical revolutions tear apart history, brings ruptures and discontinuities in the very mode of his existence, where man seeks the foundation of his own foundation (which is his metaphysical task , where occurs the dialectics of negativity between man and man, where man puts at stake his own death, his own dissolution, and by the power of his own dissolution stands in relation to the total world that he seeks to dominate. This means that man’s attempts to metaphysically found his own political and historical existence must presuppose a far more originary non-foundation, the differentiating revealing of the open, the ungrounded spacing play, or playing space of natality and mortality.

  5. Open data

    DEFF Research Database (Denmark)

    Bodum, Lars

    2017-01-01

    Everyone wants open data, but the road towards it can be both difficult and long. Implementation of data portals and ICT solutions for support of the data infrastructure can be initiated from the central government through legislation, regulation and public procurement. This is what you would call...

  6. Open Images

    DEFF Research Database (Denmark)

    Sanderhoff, Merete

    2013-01-01

    Museums around the world hold enormous troves of public domain artworks. In digitized form, they can be powerful tools for research and learning, as well as building blocks, in the hands of students, teachers, scholars, developers, and creative people. By opening up their digitized assets for reuse...

  7. Radiation shielding techniques and applications. 3. Analysis of Photon Streaming Through and Around Shield Doors

    International Nuclear Information System (INIS)

    Barnett, Marvin; Hack, Joe; Nathan, Steve; White, Travis

    2001-01-01

    Westinghouse Safety Management Solutions (Westinghouse SMS) has been tasked with providing radiological engineering design support for the new Commercial Light Water Reactor Tritium Extraction Facility (CLWR-TEF) being constructed at the Savannah River Site (SRS). The Remote Handling Building (RHB) of the CLWR-TEF will act as the receiving facility for irradiated targets used in the production of tritium for the U.S. Department of Energy (DOE). Because of the high dose rates, approaching 50 000 rads/h (500 Gy/h) from the irradiated target bundles, significant attention has been made to shielding structures within the facility. One aspect of the design that has undergone intense review is the shield doors. The RHB has six shield doors that needed to be studied with respect to photon streaming. Several aspects had to be examined to ensure that the design meets the radiation dose levels. Both the thickness and streaming issues around the door edges were designed and examined. Photon streaming through and around a shield door is a complicated problem, creating a reliance on computer modeling to perform the analyses. The computer code typically used by the Westinghouse SMS in the evaluation of photon transport through complex geometries is the MCNP Monte Carlo computer code. The complexity of the geometry within the problem can cause problems even with the Monte Carlo codes. Striking a balance between how the code handles transport through the shield door with transport through the streaming paths, particularly with the use of typical variance reduction methods, is difficult when trying to ensure that all important regions of the model are sampled appropriately. The thickness determination used a simple variance reduction technique. In construction, the shield door will not be flush against the wall, so a solid rectangular slab leaves streaming paths around the edges. Administrative controls could be used to control dose to workers; however, 10 CFR 835.1001 states

  8. Discovery of natural resources

    Science.gov (United States)

    Guild, P.W.

    1976-01-01

    Mankind will continue to need ores of more or less the types and grades used today to supply its needs for new mineral raw materials, at least until fusion or some other relatively cheap, inexhaustible energy source is developed. Most deposits being mined today were exposed at the surface or found by relatively simple geophysical or other prospecting techniques, but many of these will be depleted in the foreseeable future. The discovery of deeper or less obvious deposits to replace them will require the conjunction of science and technology to deduce the laws that governed the concentration of elements into ores and to detect and evaluate the evidence of their whereabouts. Great theoretical advances are being made to explain the origins of ore deposits and understand the general reasons for their localization. These advances have unquestionable value for exploration. Even a large deposit is, however, very small, and, with few exceptions, it was formed under conditions that have long since ceased to exist. The explorationist must suppress a great deal of "noise" to read and interpret correctly the "signals" that can define targets and guide the drilling required to find it. Is enough being done to ensure the long-term availability of mineral raw materials? The answer is probably no, in view of the expanding consumption and the difficulty of finding new deposits, but ingenuity, persistence, and continued development of new methods and tools to add to those already at hand should put off the day of "doing without" for many years. The possibility of resource exhaustion, especially in view of the long and increasing lead time needed to carry out basic field and laboratory studies in geology, geophysics, and geochemistry and to synthesize and analyze the information gained from them counsels against any letting down of our guard, however (17). Research and exploration by government, academia, and industry must be supported and encouraged; we cannot wait until an eleventh

  9. Supernovae Discovery Efficiency

    Science.gov (United States)

    John, Colin

    2018-01-01

    Abstract:We present supernovae (SN) search efficiency measurements for recent Hubble Space Telescope (HST) surveys. Efficiency is a key component to any search, and is important parameter as a correction factor for SN rates. To achieve an accurate value for efficiency, many supernovae need to be discoverable in surveys. This cannot be achieved from real SN only, due to their scarcity, so fake SN are planted. These fake supernovae—with a goal of realism in mind—yield an understanding of efficiency based on position related to other celestial objects, and brightness. To improve realism, we built a more accurate model of supernovae using a point-spread function. The next improvement to realism is planting these objects close to galaxies and of various parameters of brightness, magnitude, local galactic brightness and redshift. Once these are planted, a very accurate SN is visible and discoverable by the searcher. It is very important to find factors that affect this discovery efficiency. Exploring the factors that effect detection yields a more accurate correction factor. Further inquires into efficiency give us a better understanding of image processing, searching techniques and survey strategies, and result in an overall higher likelihood to find these events in future surveys with Hubble, James Webb, and WFIRST telescopes. After efficiency is discovered and refined with many unique surveys, it factors into measurements of SN rates versus redshift. By comparing SN rates vs redshift against the star formation rate we can test models to determine how long star systems take from the point of inception to explosion (delay time distribution). This delay time distribution is compared to SN progenitors models to get an accurate idea of what these stars were like before their deaths.

  10. RAS - Screens & Assays - Drug Discovery

    Science.gov (United States)

    The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.

  11. Discovery of the iron isotopes

    International Nuclear Information System (INIS)

    Schuh, A.; Fritsch, A.; Heim, M.; Shore, A.; Thoennessen, M.

    2010-01-01

    Twenty-eight iron isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  12. Discovery of the silver isotopes

    International Nuclear Information System (INIS)

    Schuh, A.; Fritsch, A.; Ginepro, J.Q.; Heim, M.; Shore, A.; Thoennessen, M.

    2010-01-01

    Thirty-eight silver isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  13. Synthetic biology of antimicrobial discovery

    Science.gov (United States)

    Zakeri, Bijan; Lu, Timothy K.

    2012-01-01

    Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore, used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. PMID:23654251

  14. Discovery of the cadmium isotopes

    International Nuclear Information System (INIS)

    Amos, S.; Thoennessen, M.

    2010-01-01

    Thirty-seven cadmium isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  15. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    country of discovery as well as the production mechanism used to produce the isotopes. ... the disintegration products of bombarded uranium, as a consequence of a ..... advanced accelerator and newly developed separation and detection ...

  16. Synthetic biology of antimicrobial discovery.

    Science.gov (United States)

    Zakeri, Bijan; Lu, Timothy K

    2013-07-19

    Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery.

  17. The discovery of 'heavy light'

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    The history of the discoveries of fundamental quanta is described starting from Maxwell's theory of electromagnetism up to the development of a theory of weak interaction and the detection of the W and Z bosons. (HSI).

  18. Discovery – Development of Rituximab

    Science.gov (United States)

    NCI funded the development of rituximab, one of the first monoclonal antibody cancer treatments. With the discovery of rituximab, more than 70 percent of patients diagnosed with non-hodgkin lymphoma now live five years past their initial diagnosis.

  19. Open Source, Open Access, Open Review, Open Data. Initiativen zu mehr Offenheit in der digitalen Welt

    OpenAIRE

    Herb, Ulrich

    2011-01-01

    The article discusses the principles of openess, open access and open availability of information based on the examples of open access to scientific information, open government data, open geographical data and open source software.

  20. Radioactivity. Centenary of radioactivity discovery

    International Nuclear Information System (INIS)

    Charpak, G.; Tubiana, M.; Bimbot, R.

    1997-01-01

    This small booklet was edited for the occasion of the exhibitions of the celebration of the centenary of radioactivity discovery which took place in various locations in France from 1996 to 1998. It recalls some basic knowledge concerning radioactivity and its applications: history of discovery, atoms and isotopes, radiations, measurement of ionizing radiations, natural and artificial radioactivity, isotope dating and labelling, radiotherapy, nuclear power and reactors, fission and fusion, nuclear wastes, dosimetry, effects and radioprotection. (J.S.)

  1. The narrow entrance door of Brazil's national health system (SUS: an evaluation of accessibility in the family health strategy

    Directory of Open Access Journals (Sweden)

    Ana Lucia Martins de Azevedo

    2010-01-01

    Full Text Available This study has the purpose of analyzing users' perception of the accessibility to Estratégia Saúde da Família (ESF - Family Health Strategy in its geographical, organizational, socio-cultural and economic dimensions. Process evaluation with qualitative approach through open interview, direct observation and documental analysis was performed in the city of Recife, northeastern Brazil. The main problems were: the deficient referral and counter-referral system; delayed return of laboratory test results; excessive number of families per team; difficulties in scheduling medical consultations; expenditures on medicines. Facilities were observed in the professional-user relationship, as well as in the geographical proximity of the health unit. ESF proved to be a narrow entrance door to Sistema Único de Saúde (SUS - Brazil's National Health System. Therefore, it deserves to be evaluated with a more critical look that takes into account, as a starting point, the needs of individuals who request its actions, as well as the reasoning which guides the actions of the subjects involved in care.

  2. The role of door orientation on occupant injury in a nearside impact: a CIREN, MADYMO modeling and experimental study.

    Science.gov (United States)

    Tencer, Allan F; Kaufman, Robert; Huber, Philippe; Mock, Charles

    2005-12-01

    This study addressed the effects of vehicle height mismatch in side impact crashes. A light truck or SUV tends to strike the door of a passenger car higher causing the upper border to lead into the occupant space. Conversely, an impact centered lower on the door, from a passenger car, causes the lower border to lead. We proposed the hypothesis that the type of injury sustained by the occupant could be related to door orientation during its intrusion into the passenger compartment. Data on door orientation and nearside occupant injuries were collected from 125 side impact crashes reported in the CIREN database. Experimental testing was performed using a pendulum carrying a frame and a vehicle door, impacting against a USDOT SID. The frame allowed the door orientation to be changed. A model was developed in MADYMO (v 6.2) using the more biofidelic dummies, BIOSID, and SIDIIs as well as USDOT SID. In side impact crashes with the lower border of the door leading, 81% of occupants sustained pelvic injury, 42% suffered rib fractures, and the rate of organ injury was 0.84. With the upper border leading, 46% of occupants sustained pelvic injury, 71% sustained rib fracture, and the rate of organ injuries per case increased to 1.13. The differences in the groups with respect to pelvic injury were significant at p = 0.01, rib fracture, p = 0.10, and organ injury, p = 0.001. Experimental testing showed that when the door angle changed from lower to upper border leading, peak T4 acceleration increased by 273% and pelvic acceleration decreased by 44%. The model demonstrated that when the door angle changed from lower to upper border leading, the USDOT SID showed a 29% increase in T4 acceleration and a 57% decrease in pelvic acceleration. The BIOSID dummy demonstrated a 36% increase in T1 acceleration, a 44% increase in abdominal rib 1 deflection, a 91% increase in thoracic rib 1 deflection, and a 33% decrease in pelvic acceleration. These data add more insight to the problem of

  3. Open areas and open access

    International Nuclear Information System (INIS)

    Thorndike, A.M.

    1979-01-01

    The main objective of the two open areas in the present ISABELLE design has been to provide flexibility with respect to the size and shape of experimental equipment that would eventually be installed there. No permanent building would be installed initially. One possibility would be to enclose each experiment in a temporary structure that would provide weatherproofing and shielding; another possibility would be to erect a permanent building at a later time, when experience has made the needs clearer than they are at present. The secondary objective of the design of open areas has been to keep initial costs as low as practicable. Another objective might be added, however, which we indicate by the term ''open access.'' This note will explore this idea and some design concepts based on it. In the ISABELLE 1977 summer workshop there was considerable discussion of the importance of techniques for inserting large pieces of experimental equipment quickly and removing them with equal ease and speed. Since enclosed halls have certain restrictions in this respect, open areas may be helpful in providing this feature. If the mechanical and electrical aspects could be handled quickly, one might even attempt to reduce the time spent on bureaucratic procedures in order to expedite the introduction of new experiments and new ideas in these areas

  4. Computational methods in drug discovery

    Directory of Open Access Journals (Sweden)

    Sumudu P. Leelananda

    2016-12-01

    Full Text Available The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery projects. Additionally, increasing knowledge of biological structures, as well as increasing computer power have made it possible to use computational methods effectively in various phases of the drug discovery and development pipeline. The importance of in silico tools is greater than ever before and has advanced pharmaceutical research. Here we present an overview of computational methods used in different facets of drug discovery and highlight some of the recent successes. In this review, both structure-based and ligand-based drug discovery methods are discussed. Advances in virtual high-throughput screening, protein structure prediction methods, protein–ligand docking, pharmacophore modeling and QSAR techniques are reviewed.

  5. Get Involved in Planetary Discoveries through New Worlds, New Discoveries

    Science.gov (United States)

    Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA

    2013-01-01

    "New Worlds, New Discoveries" is a synthesis of NASA’s 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun’s family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site’s event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to

  6. OpenAPC. Open-Access-Publikationskosten als Open Data

    OpenAIRE

    Tullney, Marco

    2015-01-01

    Präsentationsfolien zum Vortrag „OpenAPC. Open-Access-Publikationskosten als Open Data“ in der Session „Ausgestaltung eines wissenschaftsadäquaten APC-Marktes: Grundsätze, Finanzierungsansätze und Management“ der Open-Access-Tage 2015 in Zürich (https://www.open-access.net/community/open-access-tage/open-access-tage-2015-zuerich/programm/#c1974)

  7. Opening remarks

    International Nuclear Information System (INIS)

    Kyd, D.R.

    1993-11-01

    In his opening remarks Mr. David R. Kyd briefly described the IAEA mission. Then he outlined main aim of the seminar which is bring together journalists, educators, officials and other specialists to let them hear and put questions to experts on various aspects of nuclear energy and techniques. Further he analyzed problems and prospects of energy development in Asia and particularly in China, including environmental considerations. The final part of the remarks was devoted comparative evaluation of different energy production technologies

  8. Open Pneumothorax

    Directory of Open Access Journals (Sweden)

    Bart Paull

    2017-07-01

    Full Text Available History of present illness: A 27-year-old male was transported to the emergency department by emergency medical services after crashing his motorcycle into a guardrail. Upon presentation he was alert, normotensive, and tachypneic. Significant findings: A large chest wound was clinically obvious. A chest radiograph performed after intubation showed subcutaneous emphysema, an anterior rib fracture, and a right-sided pneumothorax. He was then taken to the operating room for further management. Discussion: Thoracic injuries are responsible for one-quarter of all trauma-related deaths. Following rib fracture, pneumothorax is the second most common thoracic injury, occurring in 30% of patients with thoracic trauma. An open pneumothorax occurs when a chest wall injury results in direct communication between the atmosphere and pleura.1-2 It is estimated that open pneumothorax occurs in 80% of all penetrating chest wounds, with stab wounds being more common than gunshot wounds or impalement. Open pneumothoraces can lead to ventilatory insufficiency and rapid respiratory decompensation.2 Advanced Trauma Life Support recommends that the initial management of an open pneumothorax is placement of an occlusive dressing taped on three sides to create a ‘flutter-valve’ mechanism. This should then be followed by tube thoracostomy and repair of the chest wall defect.3 The placement of an occlusive dressing or initial wound closure without subsequent tube thoracostomy may result in the development of a tension pneumothorax.2 The patient was intubated and mechanical ventilation was initiated without complication. Due to the large size of the wound, an occlusive dressing was not placed in the emergency department and the patient was rapidly transported to the operating room for further management. In the operating room two chest tubes were placed. Operative findings included a right hemopneumothorax, multiple rib fractures, and a manubrial fracture. After

  9. Opening address

    International Nuclear Information System (INIS)

    Ianko, L.

    1993-01-01

    This short talk was the opening remarks to the attendees at this conference, presented by the Scientific Secretary, IWG-LMNPP, of the IAEA. This meeting is an effort to aid research on problems related to the general area of nuclear plant aging and life management. In particular it addresses fracture properties of reactor materials and components, both as installed, and at end of service condition. A major concern is relating measurements made on laboratory samples to properties displayed by actual reactor components

  10. Barriers to and enablers for European rail freight transport for integrated door-to-door logistics service. Part 1: Barriers to multimodal rail freight transport

    Directory of Open Access Journals (Sweden)

    Dewan Md Zahurul ISLAM

    2014-09-01

    Full Text Available The objective of this paper is to examine and identify barriers to and enablers for the European rail freight transport services as a transport chain partner along the supply chains in the changing market scenario. The changing market scenario includes, among others, requiring 'door-to-door' rather than 'terminal to terminal' and integrated service, competitive ability to attract non-rail cargo type, changes in the customer requirements (e.g. reliable service and changes in the operational requirements and practices. Using a literature review method, the paper is presented in two parts. The part 1 focuses on the identification of barriers to the European rail freight service by reviewing freight logistics services for global supply chains followed by the current performance of European rail freight transport followed by a discussion on the rail freight market liberalisation in Europe. Then rail freight transport in the Unites States (U.S. is discussed. The research notes that although the background, scope and necessity for reform measures in Europe differ from those of the U.S., some lessons can be learned and the main lesson is that an appropriate reform measure can enhance rail sector competitive ability in Europe. Examining and identifying the barriers in the part 1 (with the pan-Pacific examples of rail freight transports, the part 2 of the paper focuses on recommending clear actions and steps as enablers for the rail freight industry in general and operators in particular. The research in part 1 of the paper finds that: •\tIn many European countries, the rail freight market is not fully liberalised. In such market segment, infrastructure managers do act independently for incumbents and new entrant operators that hamper the progress of building a competitive market; •\tThe rail operators have not yet achieved the service quality (e.g. customer tailored service needed for the modern supply chains; •\tThey operate

  11. A knitting legacy: Linda Newington opens up the doors to the University of Southampton’s fascinating knitting collections

    OpenAIRE

    Newington, Linda

    2011-01-01

    Our fascination with the knitwear of the past seems to know no bounds - the classic, elegant knits of yesteryear continue to inspire and influence designers and knitters alike. Working to collect, preserve and share these patterns is the University of Southampton Library, whose Knitting Collections contain more than 12,000 patterns from the early 20th century to the present day.The Library holds the resources of three renowned figures from the world of knitting: Montse Stanley, Richard Ruttan...

  12. Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics

    Czech Academy of Sciences Publication Activity Database

    Kadlčík, Stanislav; Kameník, Zdeněk; Vašek, Daniel; Nedvěd, Michal; Janata, Jiří

    2017-01-01

    Roč. 8, č. 5 (2017), s. 3349-3355 ISSN 2041-6520 R&D Projects: GA MŠk(CZ) LQ1604 Institutional support: RVO:61388971 Keywords : BIOCHEMICAL-CHARACTERIZATION * STREPTOMYCES-CAELESTIS * LINCOMYCIN Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 8.668, year: 2016

  13. [War and medicine in a culture of peace. 1. When the doors of the Janus temple open].

    Science.gov (United States)

    Piérard, G E

    2001-11-01

    More than 40 major wars took place during the past decade. The origins and the warlike means that were engaged were very different from those of older conflicts. Wars between nations are less numerous. They have been replaced by civilian wars that are more rooted on cultural and religious grounds than on economic interests alone. During this short period of time, warfare was responsible for about 2 millions of direct deaths and 20 millions displaced people and refugees. The injured and victims of starvation and epidemics were innumerable and awaited for civilian medical help.

  14. A unilateral open door laminoplasty technique: prospective analysis of the relationship between midline extensor muscle preservation and postoperative neck pain.

    Science.gov (United States)

    Park, Jin Hoon; Jeong, Eui-Kyun; Lee, Moon Kyu; Chul Rhim, Seung; Roh, Sung Woo; Kim, Jeoung Hee; Jeon, Sang Ryong

    2015-02-01

    Since laminoplasty was first introduced, several techniques have been developed to reduce postoperative neck pain and progressive kyphosis following this procedure. We describe the importance of deep muscle preservation to prevent postoperative neck pain following cervical posterior surgery, using the inter-muscular plane. We performed cervical laminoplasty on 10 patients from March to July 2012. The mean follow-up duration was 14.6 (range 12-18) months, and the mean age was 58.8 (48-68) years. There were eight men and two women in the study cohort, which consisted of eight cases of cervical spondylotic myelopathy and two cases of ossification of the posterior longitudinal ligament. The Japanese Orthopaedic Association (JOA) score and neck disability index (NDI) score were assessed before and at 6 and 12 months after surgery. The numeric rating scale (NRS) for neck pain was evaluated at 1, 3, 6, and 12 months after surgery. CT scan was performed immediately after the operation, and a radiograph was performed preoperatively and during the follow-up evaluation at 1, 3, 6, and 12 months after surgery. The preoperative JOA and NDI scores improved in all patients. Although there were two patients who complained of moderate postoperative neck pain (NRS 4 and 5), their condition gradually improved. Seven patients had mild or no neck pain (below NRS 3) at the 12 month follow-up. In addition, the cervical alignment was well maintained in all but one patient. Although larger prospective cohorts, longer follow-up periods, and comparative analyses are still needed, the clinical and radiological outcomes observed in the short 12 month period in this small cohort are promising. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Early Intervention Programs. Opening the Door to Higher Education. ASHE-ERIC Higher Education Report Vol. 25, No. 6.

    Science.gov (United States)

    Fenske, Robert H.; Geranios, Christine A.; Keller, Jonathan E.; Moore, David E.

    This report addresses issues related to the increasing growth of early intervention programs to encourage high school graduation and college attendance among students from low-income and minority groups. It first presents a brief review of the societal goals of equality for the nation's education system. It then defines the programs "early…

  16. Performance Measures for Teachers and Teacher Education: Corporate Education Reform Opens the Door to New Legal Issues

    Science.gov (United States)

    Pullin, Diana

    2015-01-01

    Recent efforts to change the teaching profession and teacher preparation include a number of innovations to use portfolio assessment, value added measures (VAM), accountability metrics and other corporate education reform ideas. These approaches may provoke considerable potential legal consequences. Traditional constitutional and civil rights…

  17. Variability of female responses to conspecific vs. heterospecific male mating calls in polygynous deer: an open door to hybridization?

    Directory of Open Access Journals (Sweden)

    Megan T Wyman

    Full Text Available Males of all polygynous deer species (Cervinae give conspicuous calls during the reproductive season. The extreme interspecific diversity that characterizes these vocalizations suggests that they play a strong role in species discrimination. However, interbreeding between several species of Cervinae indicates permeable interspecific reproductive barriers. This study examines the contribution of vocal behavior to female species discrimination and mating preferences in two closely related polygynous deer species known to hybridize in the wild after introductions. Specifically, we investigate the reaction of estrous female red deer (Cervus elaphus to playbacks of red deer vs. sika deer (Cervus nippon male mating calls, with the prediction that females will prefer conspecific calls. While on average female red deer preferred male red deer roars, two out of twenty females spent more time in close proximity to the speaker broadcasting male sika deer moans. We suggest that this absence of strict vocal preference for species-specific mating calls may contribute to the permeability of pre-zygotic reproductive barriers observed between these species. Our results also highlight the importance of examining inter-individual variation when studying the role of female preferences in species discrimination and intraspecific mate selection.

  18. Opening the Door: The Experience of Chronic Critical Illness in a Long-Term Acute Care Hospital.

    Science.gov (United States)

    Lamas, Daniela J; Owens, Robert L; Nace, R Nicholas; Massaro, Anthony F; Pertsch, Nathan J; Gass, Jonathon; Bernacki, Rachelle E; Block, Susan D

    2017-04-01

    Chronically critically ill patients have recurrent infections, organ dysfunction, and at least half die within 1 year. They are frequently cared for in long-term acute care hospitals, yet little is known about their experience in this setting. Our objective was to explore the understanding and expectations and goals of these patients and surrogates. We conducted semi-structured interviews with chronically critically ill long-term acute care hospital patients or surrogates. Conversations were recorded, transcribed, and analyzed. One long-term acute care hospital. Chronically critically ill patients, defined by tracheotomy for prolonged mechanical ventilation, or surrogates. Semi-structured conversation about quality of life, expectations, and planning for setbacks. A total of 50 subjects (30 patients and 20 surrogates) were enrolled. Thematic analyses demonstrated: 1) poor quality of life for patients; 2) surrogate stress and anxiety; 3) optimistic health expectations; 4) poor planning for medical setbacks; and 5) disruptive care transitions. Nearly 80% of patient and their surrogate decision makers identified going home as a goal; 38% were at home at 1 year. Our study describes the experience of chronically critically ill patients and surrogates in an long-term acute care hospital and the feasibility of patient-focused research in this setting. Our findings indicate overly optimistic expectations about return home and unmet palliative care needs, suggesting the need for integration of palliative care within the long-term acute care hospital. Further research is also needed to more fully understand the challenges of this growing population of ICU survivors.

  19. The best and brightest. Concern over tomorrow's workforce opens new doors for education and training in nuclear fields

    International Nuclear Information System (INIS)

    Wedekind, Lothar

    2001-01-01

    The article discusses the results of a study by the Nuclear Energy Agency to address concerns about downward trends in nuclear education and training at universities. The implications of a shortage of trained nuclear energy specialists are discussed

  20. Centenary of the discovery of superconductivity

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    To mark the centenary of the discovery of the phenomenon of superconductivity, MANEP and the University of Geneva are organising open days at the PhysiScope between 8 and 15 April 2011. On 13 April CERN will make a contribution to the series of events with a lecture on superconductivity followed by a demonstration of the phenomenon at the Globe   Historic graph showing the superconducting transition of mercury, measured in Leiden in 1911 by H. Kamerlingh Onnes. On 8 April 2011 it will be a hundred years since the discovery of superconductivity by the Dutch physicist Kamerlingh Onnes. To mark the occasion, the University of Geneva and MANEP are organising a week-long interactive workshop at the PhysiScope. “The purpose of this initiative is to introduce the general public to this spectacular phenomenon by giving them an opportunity to take part in entertaining experiments”, explains Adriana Aleman, Head of Communications of the University of Geneva. As its contribution to the e...