WorldWideScience

Sample records for discovery opens door

  1. China opens the door

    Energy Technology Data Exchange (ETDEWEB)

    Starke, K.

    1997-01-01

    The door to China`s vast market for power generation was opened a bit further for foreign firms in November. That is when power ministry head Shi Dazhen said the country would rely on overseas investors for 20 percent of the funding needed to boost output--double the amount foreigners were previously allowed to contribute. Through 1995, foreigners invested $12.2 billion in China`s electricity industry, accounting for 10 percent of total investment. According to Shi, foreign investors will be asked to provide about $17 billion of the $84 billion China plans to invest in the sector over the next five years. Under China`s Ninth Five-Year Plan (1996-2000), the government aims to boost the country`s power generation capacity at the rate of 15,000 MW to 20,000 MW annually by the year 2000. Since China`s public external debt balance already exceeds $80 billion, however, the government would seem to have little choice but to allow foreigners a greater role. Shi also said that foreigners would be allowed 100 percent ownership of PRC power projects. This is discouraged under China`s current industry guidelines. It is, however, expected to be permitted under China`s first build-operate-transfer (BOT) law, which was anticipated by the end of 1996, says Susan Urkevich, director of project finance at HSBC Investment Bank Asia in Hong Kong. Indeed, China`s first BOT is already happening.

  2. September 2013: the doors open

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    Three special days and one public open day: at the end of September our Laboratory will open its doors to visitors from CERN, the local region and all over the world. With over 150,000 visitors expected in total, the organisation of the OpenDays is a challenge that a core team of eleven people have taken up with enthusiasm.   They come from several departments but share one goal: making the last four days of September an unforgettable experience for all the visitors who will come to discover the Laboratory and its scientists. The core team in charge of the organisation of the events is co-ordinated by Hermann Schmickler. “The events are an opportunity for us to celebrate  the discoveries, the excellent performance of the technical installations and the vital contribution of all the CERN personnel, the thousands of users and those working under support contracts,” says Hermann Schmickler. The four-day programme will start on Friday 27 September with an “...

  3. Project Open Door. Final Report.

    Science.gov (United States)

    Verheyden-Hilliard, Mary Ellen

    The major purpose of Project Open Door was to design, develop, test, and disseminate a portable module for vocational educators and others to use with junior high school students in pre-vocational exploration free of sex stereotyping. The module produced contained a slide presentation with accompanying cassette tape and a leader's guide. An…

  4. Opening the door to innovation.

    Science.gov (United States)

    Schuurman, Janine; Graus, Yvo F; Labrijn, Aran F; Ruuls, Sigrid; Parren, Paul W H I

    2014-01-01

    Open innovation is the new buzz, with initiatives popping up left and right. Here, we give a personal perspective on a very successful, knowledge-driven innovation initiated in an academia- industry alliance, which culminated in technology platforms that enable the generation of therapeutic antibodies with novel properties. To start, we provide a general background on open innovation in the drug development field.

  5. Opening the doors: building brand awareness.

    Science.gov (United States)

    John, Judith; McCartney, Rob

    2006-01-01

    In search of a credible and cost-effective way to promote Mount Sinai Hospital (Mount Sinai) and educate a broad public, Mount Sinai opened its doors wide to The Globe and Mail (The Globe). The result was a three-part national feature series that told Mount Sinai's compelling story, provided third-party credibility and confirmed the value of proactive media relations. The series engaged our staff, energized our volunteers and reached both stakeholders and the general public on an emotional level. It also generated the more than dollars 6 million worth of equivalent advertising space it would have required for Mount Sinai to reach this national audience.

  6. Ombuds’ corner: Open door and confidentiality

    CERN Multimedia

    Vincent Vuillemin

    2013-01-01

    For the Open Days, CERN will be transparent for all visitors. It's also the occasion to remember that the Ombuds' door is fully open every day of the year for all persons working for or on behalf of CERN.   The door is open, but as soon as it's closed for a discussion, the office becomes a place where total confidentiality is preserved. This may appear as a contradiction, no? The Ombuds is available to help everyone in all circumstances, but his clause of confidentiality prevents him from acting without the consent of his “visitors”. How can he possibly resolve the in-house conflicts in groups, or units, if all the parties do not voluntarily participate in its resolution? The answer is clear: the job of the Ombuds is to help the parties resolve their conflict by themselves. He will provide a few rules of communication, a process of mutual respect, suggest some possibilities that the parties may want to follow, and mediate the dispute so that people...

  7. Golden Jubilee Photos: Doors wide open

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ The reception area and visits desk (formerly PIO - Public Information Office) in 1972. Régine Chareyron (on the right), who has worked for the Visits Service for 35 years, is pictured here with Chantal Montuel and Cora Roth. CERN inaugurated its permanent visitor centre "Microcosm" in 1989. This brand new outreach facility added a crowning touch to CERN's tradition of openness in conducting its research activities. In keeping with Article II of the Convention, which stipulates that "the results of its (...) work shall be published or otherwise made available," CERN was already organising visits for the general public in the late 1950s, with members of the personnel doubling up as voluntary tour guides. By 1959, the Laboratory was opening its doors to almost 2 500 visitors a year. Ten years down the line, that number had risen to 12 700, and today CERN welcomes some 30 000 visitors through its doors every year. In addition, the Visits Service has developed teaching packs for sc...

  8. Failure case of a garage door opener

    Directory of Open Access Journals (Sweden)

    Habib, K.

    2005-12-01

    Full Text Available A failure analysis of a garage door opener was conducted for determination of the cause of the failure. The analysis included visual inspections of broken parts as well as electron microscopy examinations of the fracture surface. The visual inspections showed that a bolt connected to the inner trolley of the garage opener assembly was initially fractured. Also, the results of electron microscopy examinations revealed that the broken bolt failed by fatigue damage phenomenon, due to alternating torsional stresses throughout 25 years of an operational life of the garage opener. In addition, a mathematical model corresponding to the failure mechanism was derived along the failure analysis. The model comprises of both design philosophy and fracture mechanics approaches.

    Se analizó el fallo del mecanismo de apertura de una puerta de garaje con el fin de determinar sus causas. El análisis incluyó una inspección visual de las piezas rotas así como un examen mediante microscopía de la superficie de fractura. La inspección visual reveló que primero se fracturó un perno conectado al carro interior del mecanismo de apertura. Los resultados del análisis por microscopía electrónica también mostraron que el perno roto falló debido a fenómenos de daño por fatiga, debido a los esfuerzos torsionales alternos a la largo de 25 años de vida en servicio del mecanismo de apertura. Por otra parte, se construyó un modelo matemático correspondiente al mecanismo de rotura durante el análisis del mismo. Este modelo comprende enfoques, tanto de la filosofía de diseño como de la mecánica de fractura.

  9. From "Closing Doors" to "Opening Doors": Exploring gender and subject choice in UK schools

    Science.gov (United States)

    Marks, Ann

    2015-12-01

    Two reports drawing on the National (English) Pupil Database are discussed: the It's Different for Girls and the Closing Doors reports (2012 and 2013, respectively), both of which examine the experience of girls studying physics in England. The UK government has responded to these studies by launching the "Opening Doors" project (June 2014), which will focus on a whole-school approach to addressing gender imbalance in progression to post-16 studies.

  10. SOFIA Closed- and Open-Door Aerodynamic Analyses

    Science.gov (United States)

    Cumming, Stephen; Frederick, Mike; Smith, Mark

    2012-01-01

    Work to evaluate the aerodynamic characteristics and the cavity acoustic environment of the SOFIA (Stratospheric Observatory for Infrared Astronomy) airplane has been completed. The airplane has been evaluated in its closed-door configuration, as well as several open-door configurations. Work performed included: acoustic analysis tool development, cavity acoustic evaluation, stability and control parameter estimation, air data calibration, and external flow evaluation. Qualitative airflow data were obtained during the closed- and open-door flights using tufts on the aft portion of the fuselage. Video was taken from a chase plane. This video was analyzed for various flight conditions, and general flow descriptions of the aft fuselage of the 747SP were developed for the different closed and open door configurations.

  11. Door Opening Affects Operating Room Pressure During Joint Arthroplasty.

    Science.gov (United States)

    Mears, Simon C; Blanding, Renee; Belkoff, Stephen M

    2015-11-01

    Many resources are expended to ensure a sterile operating room environment. Efforts are made to prevent exposure of patients to personnel and to achieve positive room pressure to keep out airborne contaminants. Foot traffic into and out of the operating room during surgery can undermine these efforts. The authors investigated the number and duration of operating room door openings during hip and knee arthroplasty procedures and the effect of the door openings on room pressure. They tested the hypothesis that door openings defeat positive pressure, permitting air flow into the room. Room pressure and door status were monitored electronically during 191 hip and knee arthroplasty procedures. Operating room staff were unaware that data were being collected. The authors evaluated the data with regression analysis to determine whether the number and duration of door openings had an effect on room pressure. Significance was set at Poperating room. Total time with the door open significantly affected the minimum pressure recorded in the room (Poperating room sterility. The causes of excessive operating room traffic must be evaluated to identify ways to reduce this traffic and the associated risks.

  12. OPEN DATA FOR DISCOVERY SCIENCE.

    Science.gov (United States)

    Payne, Philip R O; Huang, Kun; Shah, Nigam H; Tenenbaum, Jessica

    2016-01-01

    The modern healthcare and life sciences ecosystem is moving towards an increasingly open and data-centric approach to discovery science. This evolving paradigm is predicated on a complex set of information needs related to our collective ability to share, discover, reuse, integrate, and analyze open biological, clinical, and population level data resources of varying composition, granularity, and syntactic or semantic consistency. Such an evolution is further impacted by a concomitant growth in the size of data sets that can and should be employed for both hypothesis discovery and testing. When such open data can be accessed and employed for discovery purposes, a broad spectrum of high impact end-points is made possible. These span the spectrum from identification of de novo biomarker complexes that can inform precision medicine, to the repositioning or repurposing of extant agents for new and cost-effective therapies, to the assessment of population level influences on disease and wellness. Of note, these types of uses of open data can be either primary, wherein open data is the substantive basis for inquiry, or secondary, wherein open data is used to augment or enrich project-specific or proprietary data that is not open in and of itself. This workshop is concerned with the key challenges, opportunities, and methodological best practices whereby open data can be used to drive the advancement of discovery science in all of the aforementioned capacities.

  13. Coal Discovery Trail officially opens

    Energy Technology Data Exchange (ETDEWEB)

    Gallinger, C. [Elk Valley Coal Corporation, Sparwood, BC (Canada)

    2004-09-01

    The opening of the 30-kilometre Coal Discovery Trail in August is described. The trail, through a pine, spruce, and larch forest, extends from Sparwood to Fernie and passes through Hosmer, a historic mining site. The trail, part of the Elk Valley Coal Discovery Centre, will be used for hiking, bicycling, horseback riding, and cross-country skiing. The Coal Discovery Centre will provide an interpretive centre that concentrates on history of coal mining and miners, preservation of mining artifacts and sites, and existing technology. 3 figs.

  14. A professional curriculum vitae will open career doors.

    Science.gov (United States)

    Harper, D S

    1999-01-01

    In today's challenging healthcare environment, it is essential for nurse practitioners to be able to describe themselves professionally on paper to compete for practice and academic opportunities. Nurse practitioners are competing with physician assistants as well as physicians for primary and acute care positions. A carefully compiled curriculum vitae will present the individual in the best light possible to help open career doors and enhance chances of success. Preparing a curriculum vitae will serve to highlight relevant professional accomplishments, whatever the setting, toward the fulfillment of professional goals. This article reviews the current professional print and electronic literature on preparing a curriculum vitae to assist the nurse practitioner in developing this vital document.

  15. Keeping the Doors of Learning Open for Adult Student-Workers within Higher Education?

    Science.gov (United States)

    Walters, Shirley; Abrahams, Mark; Witbooi, Sally

    2015-01-01

    The Freedom Charter of the African National Congress (ANC), the triumphant South African liberation movement, proclaims that "the doors of learning shall be open" for all. Twenty years since coming to power, the doors of the universities are struggling to stay open for adult student-workers. An action research project into implementation…

  16. The CERN Global Network opens its doors to companies

    CERN Multimedia

    Francesco Poppi

    2010-01-01

    Six months after its launch, the CERN Global Network already has almost one thousand members. Today, it is opening its doors to companies from CERN's Member States. This will open up a variety of new professional and career opportunities to all the members and will enhance the networking capabilities of all parties involved.   Screenshot of the CERN Global Network website. A new item has recently appeared on the top menu of the Network's website: “Organisations”. This is the entry point for companies and, later, research institutes, wishing to join. “The CERN Global Network brings together hundreds of people who have worked at or with CERN and who have a wealth of skills and expertise. Thanks to the Network, the job opportunities made available by the companies will become visible to the wider community,” says Linda Orr-Easo, a member of the Knowledge and Technology Transfer Group and the CERN Global Network Manager. In addition to creating new career opp...

  17. Novel Door-opening Method for Six-legged Robots Based on Only Force Sensing

    Science.gov (United States)

    Chen, Zhi-Jun; Gao, Feng; Pan, Yang

    2017-09-01

    Current door-opening methods are mainly developed on tracked, wheeled and biped robots by applying multi-DOF manipulators and vision systems. However, door-opening methods for six-legged robots are seldom studied, especially using 0-DOF tools to operate and only force sensing to detect. A novel door-opening method for six-legged robots is developed and implemented to the six-parallel-legged robot. The kinematic model of the six-parallel-legged robot is established and the model of measuring the positional relationship between the robot and the door is proposed. The measurement model is completely based on only force sensing. The real-time trajectory planning method and the control strategy are designed. The trajectory planning method allows the maximum angle between the sagittal axis of the robot body and the normal line of the door plane to be 45º. A 0-DOF tool mounted to the robot body is applied to operate. By integrating with the body, the tool has 6 DOFs and enough workspace to operate. The loose grasp achieved by the tool helps release the inner force in the tool. Experiments are carried out to validate the method. The results show that the method is effective and robust in opening doors wider than 1 m. This paper proposes a novel door-opening method for six-legged robots, which notably uses a 0-DOF tool and only force sensing to detect and open the door.

  18. LS1 Report: As one door closes, another opens

    CERN Multimedia

    Katarina Anthony & Anaïs Schaeffer

    2014-01-01

    Across the PS complex - from Linac 2 to TT2 to the accelerator itself - teams have seen the closing of their retro-1980s entryways, and the opening of state-of-the-art access points in compliance with the highest nuclear safety standards.   One of the new PS access points. The new PS access system provides more than just doors. Designed to protect against the radiation hazards and other risks caused by machine operation, the access system will monitor who goes into each zone, check whether or not the individual has the appropriate permissions to be entering, and even stop the beam if access is attempted during beam mode. "These new points provide automatic means to check that the right people are going in and in safe circumstances," says Pierre Ninin, project leader of the PS complex safety system. "All of these checks were previously done manually, so the burden on operators has been significantly reduced." The 19 new access points were successfully insta...

  19. Open PHACTS: semantic interoperability for drug discovery.

    Science.gov (United States)

    Williams, Antony J; Harland, Lee; Groth, Paul; Pettifer, Stephen; Chichester, Christine; Willighagen, Egon L; Evelo, Chris T; Blomberg, Niklas; Ecker, Gerhard; Goble, Carole; Mons, Barend

    2012-11-01

    Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially.

  20. Patterns of post-cabinet careers: When one door closes another door opens?

    NARCIS (Netherlands)

    Dörrenbächer, N.

    2016-01-01

    This article tackles the question to what extent former cabinet members go through the so-called revolving door by starting a second career in the private sector, and what factors make them likely to do so. After a cabinet position, career advancement in the political and public sector is difficult.

  1. Volunteers: the key that opens the doors for the Open Days

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    2013: the year that CERN opens its doors to the public. 2013 is also the approximate number of volunteers needed to ensure that these Open Days (JPO) go ahead smoothly. Whatever your personnel status and function, you, the volunteers, are the key without which the Laboratory’s doors could not really open. Sign up now!   1,500 of you volunteered for the LHC2008 open days to mark the inauguration of the LHC. This year, with roughly 20% more visitors expected across the CERN sites over the two days, the organisers envisage closer to 2,000 volunteers. “We will be holding a wide variety of activities across the Laboratory’s various sites,” explains Virginie Blondeau, the member of the Open Days organising team in charge of recruiting and training volunteers. “As well as guides for the experiments, we will also need volunteers to welcome and direct visitors, to help with logistics and to man the sales points, etc.” The volunteers will rec...

  2. Microscopy Opening Up New Cancer Discovery Avenues

    Science.gov (United States)

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  3. Open source drug discovery--a new paradigm of collaborative research in tuberculosis drug development.

    Science.gov (United States)

    Bhardwaj, Anshu; Scaria, Vinod; Raghava, Gajendra Pal Singh; Lynn, Andrew Michael; Chandra, Nagasuma; Banerjee, Sulagna; Raghunandanan, Muthukurussi V; Pandey, Vikas; Taneja, Bhupesh; Yadav, Jyoti; Dash, Debasis; Bhattacharya, Jaijit; Misra, Amit; Kumar, Anil; Ramachandran, Srinivasan; Thomas, Zakir; Brahmachari, Samir K

    2011-09-01

    It is being realized that the traditional closed-door and market driven approaches for drug discovery may not be the best suited model for the diseases of the developing world such as tuberculosis and malaria, because most patients suffering from these diseases have poor paying capacity. To ensure that new drugs are created for patients suffering from these diseases, it is necessary to formulate an alternate paradigm of drug discovery process. The current model constrained by limitations for collaboration and for sharing of resources with confidentiality hampers the opportunities for bringing expertise from diverse fields. These limitations hinder the possibilities of lowering the cost of drug discovery. The Open Source Drug Discovery project initiated by Council of Scientific and Industrial Research, India has adopted an open source model to power wide participation across geographical borders. Open Source Drug Discovery emphasizes integrative science through collaboration, open-sharing, taking up multi-faceted approaches and accruing benefits from advances on different fronts of new drug discovery. Because the open source model is based on community participation, it has the potential to self-sustain continuous development by generating a storehouse of alternatives towards continued pursuit for new drug discovery. Since the inventions are community generated, the new chemical entities developed by Open Source Drug Discovery will be taken up for clinical trial in a non-exclusive manner by participation of multiple companies with majority funding from Open Source Drug Discovery. This will ensure availability of drugs through a lower cost community driven drug discovery process for diseases afflicting people with poor paying capacity. Hopefully what LINUX the World Wide Web have done for the information technology, Open Source Drug Discovery will do for drug discovery.

  4. Open Drug Discovery Toolkit (ODDT): a new open-source player in the drug discovery field.

    Science.gov (United States)

    Wójcikowski, Maciej; Zielenkiewicz, Piotr; Siedlecki, Pawel

    2015-01-01

    There has been huge progress in the open cheminformatics field in both methods and software development. Unfortunately, there has been little effort to unite those methods and software into one package. We here describe the Open Drug Discovery Toolkit (ODDT), which aims to fulfill the need for comprehensive and open source drug discovery software. The Open Drug Discovery Toolkit was developed as a free and open source tool for both computer aided drug discovery (CADD) developers and researchers. ODDT reimplements many state-of-the-art methods, such as machine learning scoring functions (RF-Score and NNScore) and wraps other external software to ease the process of developing CADD pipelines. ODDT is an out-of-the-box solution designed to be easily customizable and extensible. Therefore, users are strongly encouraged to extend it and develop new methods. We here present three use cases for ODDT in common tasks in computer-aided drug discovery. Open Drug Discovery Toolkit is released on a permissive 3-clause BSD license for both academic and industrial use. ODDT's source code, additional examples and documentation are available on GitHub (https://github.com/oddt/oddt).

  5. Implications of China's Open-Door Policy for Families: A Family Impact Analysis

    Science.gov (United States)

    Quach, Andrew S.; Anderson, Elaine A.

    2008-01-01

    China's open-door policy (ODP) was created in 1978 as a response to the severe economic depression affecting the country after the Cultural Revolution. The policy was designed to restore China's financial status and lift the nation out of destitution. By all accounts, the ODP has been successful in improving the country's monetary condition.…

  6. Implications of China's Open-Door Policy for Families: A Family Impact Analysis

    Science.gov (United States)

    Quach, Andrew S.; Anderson, Elaine A.

    2008-01-01

    China's open-door policy (ODP) was created in 1978 as a response to the severe economic depression affecting the country after the Cultural Revolution. The policy was designed to restore China's financial status and lift the nation out of destitution. By all accounts, the ODP has been successful in improving the country's monetary condition.…

  7. [Changes of sagittal balance of cervical spine after open-door expansive laminoplasty].

    Science.gov (United States)

    Lin, Shengrong; Zhou, Feifei; Sun, Yu; Chen, Zhongqiang; Zhang, Fengshan; Pan, Shengfa

    2014-09-23

    To explore the changes of sagittal balance of cervical spine after open-door expansive laminoplasty. The clinical and radiological data were analyzed retrospectively for 90 patients undergoing open-door expansive laminoplasty due to cervical spondylotic myelopathy. The Japanese Orthopedic Association (JOA) score and 3 cervical sagittal parameters including C2-C7 SVA, C0-2 Cobb angle and T1-Slope on lateral view radiographs were recorded before operation and at the final follow-up. The average follow-up period was 16.7 (3-40) months. The post-operative JOA score rose to 14.6 ± 0.2 from pre-operative 12.2 ± 0.3 with 43.5% ± 4.2% recovery rate. The post-operative values of C2-C7 SVA, C0-2 Cobb angle and T1-Slope were significantly different from pre-operative ones (P = 0.022, P cervical spine significantly changes after open-door expansive laminoplasty with forward tilting of cervical vertebra. And compensation occurs by excessive high-strength contraction of posterior muscles to maintain lordosis in upper cervical spine. A higher pre-OP T1-Slope affects the outcomes of open-door expansive laminoplasty.

  8. "On the gate of Arctic": Doors open to foreign schools

    Science.gov (United States)

    Pecchiar, Irene

    2015-04-01

    With the increased attention to the changing of the Arctic Region as a consequence of global climate changes, effective science education, outreach and communication need to be higher priorities within the scientific communities. In order to encourage the dissemination of polar research at educational levels Slovene high school students in Trieste were first engaged at school and at the National Museum of Antarctica of Trieste using conferences and laboratory activities to introduce the main polar climate change topics. Then together with three teachers they visited Tromso University (North Norway) for a week. The first aim of this project was to increase awareness of foreign schools on major topics concerning the Arctic issues (from the economic/social to the environmental/climatic point of view). Forty-three high school students were involved in the laboratory activities running at the University of Tromso and participated in seminars. The topics focused on were Ocean Acidification, Global Warming and the combined effects with other anthropogenic stressors. During their stay, students interviewed several scientists in order to allow them to edit a »visiting report«, that was updated every day in their blog and to elaborate all the material collected (photos, videos, data of laboratory work, reports). In Tromso, they were also introduced to the culture and tradition of the Scandinavian indigenous people at the Center of Sami Study. Back in Italy, they published some articles in local newspapers, and then they presented their results at the National Museum of Antarctica of Trieste about all the data elaboration in an open day exhibition with posters, short movies and PowerPoint presentations. All this work was made in order to pass their experience into the world. This was a pilot project, highlighting the role of universities as links between research and outreach. The next step should be to enlarge these kinds of activities to many Schools, Universities and

  9. Influence of Geometrical Imperfections on Analyses of Door Openings in Tubular Steel Towers for Wind Turbines.

    OpenAIRE

    Tran, Anh Tuan; Veljkovic, Milan, ed. lit.; Rebelo, Carlos; Da Silva, Luís Simões

    2014-01-01

    Towers for wind turbines are very sensitive to geometrical imperfections. Pattern and amplitude of imperfections significantly influence the strength of the towers. Rather limited number of experiments exists on a tubular tower like structure and no experiments are available considering door opening in towers with cylindrical or polygonal cross-section. One of the objectives of the RFCS research project “HIGH STEEL TUBULAR TOWERS FOR WIND TURBINES, HISTIWIN2” was to investigate current practi...

  10. Open data in drug discovery and development: lessons from malaria.

    Science.gov (United States)

    Wells, Timothy N C; Willis, Paul; Burrows, Jeremy N; Hooft van Huijsduijnen, Rob

    2016-10-01

    There is a growing consensus that drug discovery thrives in an open environment. Here, we describe how the malaria community has embraced four levels of open data - open science, open innovation, open access and open source - to catalyse the development of new medicines, and consider principles that could enable open data approaches to be applied to other disease areas.

  11. Numerical modeling of cold room's hinged door opening and closing processes

    Science.gov (United States)

    Carneiro, R.; Gaspar, P. D.; Silva, P. D.; Domingues, L. C.

    2016-06-01

    The need of rationalize energy consumption in agrifood industry has fasten the development of methodologies to improve the thermal and energy performances of cold rooms. This paper presents a three-dimensional (3D) transient Computational Fluid Dynamics (CFD) modelling of a cold room to evaluate the air infiltration rate through hinged doors. A species transport model is used for modelling the tracer gas concentration decay technique. Numerical predictions indicate that air temperature difference between spaces affects the air infiltration. For this case study, the infiltration rate increases 0.016 m3 s-1 per K of air temperature difference. The knowledge about the evolution of air infiltration during door opening/closing times allows to draw some conclusions about its influence on the air conditions inside the cold room, as well as to suggest best practices and simple technical improvements that can minimize air infiltration, and consequently improve thermal performance and energy consumption rationalization.

  12. Quality of life in symptomatic cervical myelopathy after open-door laminoplasty

    Directory of Open Access Journals (Sweden)

    Rodrigo Yuiti Nakao

    2015-06-01

    Full Text Available OBJECTIVE: To analyze the results obtained by open-door laminoplasty using the Newbridge(r/Blackstone plate, in cases of myelopathy associated with cervical lordosis.METHODS: From December 2010 to October 2012, eight patients between the ages of 49 and 68 underwent open-door laminoplasty with the use of the Newbridge(r fixation system for maintenance and stabilization of the cervical laminoplasty. Minimum follow-up was four months. For the evaluation of quality of life the questionnaire SF-36 was applied at the following times: preoperative, one month and three months after surgery associated with the subjective assessment of the patient regarding satisfaction with the procedure and with the Nurick neurological scale applied prior to surgery and three months later.RESULTS: According to the SF-36, there was significant improvement in the domains functional ability, general health perceptions and emotional aspects over time; regarding physical limitations and social aspects there was no improvement in the first postoperative month, only in the third month. There were no statistically significant changes observed during the period covered by this study related to pain, vitality and mental health. According to Nurick scale, there was evidence of improvement in symptoms of cervical myelopathy. Based on the subjective evaluation of the patients, surprisingly, all patients were satisfied with the surgical procedure and the results.CONCLUSION: The open-door laminoplasty technique with rigid fixation to maintain the opening is useful in improving the symptoms of cervical myelopathy associated with lordosis, leading to improved quality of life and with a high degree of patient satisfaction and fewer complications.

  13. Different types of door-opening motions as contributing factors to containment failures in hospital isolation rooms.

    Science.gov (United States)

    Tang, Julian W; Nicolle, Andre; Pantelic, Jovan; Klettner, Christian A; Su, Ruikun; Kalliomaki, Petri; Saarinen, Pekka; Koskela, Hannu; Reijula, Kari; Mustakallio, Panu; Cheong, David K W; Sekhar, Chandra; Tham, Kwok Wai

    2013-01-01

    Hospital isolation rooms are vital for the containment (when under negative pressure) of patients with, or the protection (when under positive pressure) of patients, from airborne infectious agents. Such facilities were essential for the management of highly contagious patients during the 2003 severe acute respiratory syndrome (SARS) outbreaks and the more recent 2009 A/H1N1 influenza pandemic. Many different types of door designs are used in the construction of such isolation rooms, which may be related to the space available and affordability. Using colored food dye as a tracer, the qualitative effects of door-opening motions on the dissemination of potentially contaminated air into and out of a single isolation room were visualized and filmed using Reynolds-number-equivalent, small-scale, water-tank models fitted with programmable door-opening and moving human figure motions. Careful scaling considerations involved in the design and construction of these water-tank models enabled these results to be accurately extrapolated to the full-scale situation. Four simple types of door design were tested: variable speed single and double, sliding and hinged doors, in combination with the moving human figure. The resulting video footage was edited, synchronized and presented in a series of split-screen formats. From these experiments, it is clear that double-hinged doors pose the greatest risk of leakage into or out of the room, followed by (in order of decreasing risk) single-hinged, double-sliding and single-sliding doors. The relative effect of the moving human figure on spreading any potential contamination was greatest with the sliding doors, as the bulk airflows induced were large relative to those resulting from these door-opening motions. However, with the hinged doors, the airflows induced by these door-opening motions were significantly greater. Further experiments involving a simulated ventilated environment are required, but from these findings alone, it

  14. Different types of door-opening motions as contributing factors to containment failures in hospital isolation rooms.

    Directory of Open Access Journals (Sweden)

    Julian W Tang

    Full Text Available Hospital isolation rooms are vital for the containment (when under negative pressure of patients with, or the protection (when under positive pressure of patients, from airborne infectious agents. Such facilities were essential for the management of highly contagious patients during the 2003 severe acute respiratory syndrome (SARS outbreaks and the more recent 2009 A/H1N1 influenza pandemic. Many different types of door designs are used in the construction of such isolation rooms, which may be related to the space available and affordability. Using colored food dye as a tracer, the qualitative effects of door-opening motions on the dissemination of potentially contaminated air into and out of a single isolation room were visualized and filmed using Reynolds-number-equivalent, small-scale, water-tank models fitted with programmable door-opening and moving human figure motions. Careful scaling considerations involved in the design and construction of these water-tank models enabled these results to be accurately extrapolated to the full-scale situation. Four simple types of door design were tested: variable speed single and double, sliding and hinged doors, in combination with the moving human figure. The resulting video footage was edited, synchronized and presented in a series of split-screen formats. From these experiments, it is clear that double-hinged doors pose the greatest risk of leakage into or out of the room, followed by (in order of decreasing risk single-hinged, double-sliding and single-sliding doors. The relative effect of the moving human figure on spreading any potential contamination was greatest with the sliding doors, as the bulk airflows induced were large relative to those resulting from these door-opening motions. However, with the hinged doors, the airflows induced by these door-opening motions were significantly greater. Further experiments involving a simulated ventilated environment are required, but from these findings

  15. Different Types of Door-Opening Motions as Contributing Factors to Containment Failures in Hospital Isolation Rooms

    Science.gov (United States)

    Tang, Julian W.; Nicolle, Andre; Pantelic, Jovan; Klettner, Christian A.; Su, Ruikun; Kalliomaki, Petri; Saarinen, Pekka; Koskela, Hannu; Reijula, Kari; Mustakallio, Panu; Cheong, David K. W.; Sekhar, Chandra; Tham, Kwok Wai

    2013-01-01

    Hospital isolation rooms are vital for the containment (when under negative pressure) of patients with, or the protection (when under positive pressure) of patients, from airborne infectious agents. Such facilities were essential for the management of highly contagious patients during the 2003 severe acute respiratory syndrome (SARS) outbreaks and the more recent 2009 A/H1N1 influenza pandemic. Many different types of door designs are used in the construction of such isolation rooms, which may be related to the space available and affordability. Using colored food dye as a tracer, the qualitative effects of door-opening motions on the dissemination of potentially contaminated air into and out of a single isolation room were visualized and filmed using Reynolds-number-equivalent, small-scale, water-tank models fitted with programmable door-opening and moving human figure motions. Careful scaling considerations involved in the design and construction of these water-tank models enabled these results to be accurately extrapolated to the full-scale situation. Four simple types of door design were tested: variable speed single and double, sliding and hinged doors, in combination with the moving human figure. The resulting video footage was edited, synchronized and presented in a series of split-screen formats. From these experiments, it is clear that double-hinged doors pose the greatest risk of leakage into or out of the room, followed by (in order of decreasing risk) single-hinged, double-sliding and single-sliding doors. The relative effect of the moving human figure on spreading any potential contamination was greatest with the sliding doors, as the bulk airflows induced were large relative to those resulting from these door-opening motions. However, with the hinged doors, the airflows induced by these door-opening motions were significantly greater. Further experiments involving a simulated ventilated environment are required, but from these findings alone, it

  16. Closed windows, open doors: geopolitics and post-1949 mainland Chinese immigration to Canada.

    Science.gov (United States)

    Liu X-f; Norcliffe, G

    1996-01-01

    "Since 1949 there have been dramatic changes in the flow of migrants from Mainland China to Canada.... Even though Canada in theory opened a window for family reunification in the postwar era by removing long-standing discriminatory clauses blocking Chinese immigration, in practice cold war geopolitics led the Chinese to shut that window, blocking nearly all emigration. Changing geopolitical circumstances led China to develop an open-door policy between 1973 and 1989, leading to increasing flows of migrants to Canada. The political response in Canada to the Tiananmen Square massacre of 1989 was to allow all Chinese students and workers in Canada to stay, if they so wished.... The result was a large inflow making MCIs [mainland Chinese immigrants] the third-largest group of immigrants to Canada in the early 1990s." (EXCERPT)

  17. Open Access, Education Research, and Discovery

    Science.gov (United States)

    Furlough, Michael

    2010-01-01

    Background/Context: The open access movement has successfully drawn attention to economic and political aspects of scholarly communication through a significant body of commentary that debates the merits of open access and the potential damage it may do to scholarly publishing. Researchers within the field of education research, notably John…

  18. Open Access, Education Research, and Discovery

    Science.gov (United States)

    Furlough, Michael

    2010-01-01

    Background/Context: The open access movement has successfully drawn attention to economic and political aspects of scholarly communication through a significant body of commentary that debates the merits of open access and the potential damage it may do to scholarly publishing. Researchers within the field of education research, notably John…

  19. OPENING REMARKS: Scientific Discovery through Advanced Computing

    Science.gov (United States)

    Strayer, Michael

    2006-01-01

    as the national and regional electricity grid, carbon sequestration, virtual engineering, and the nuclear fuel cycle. The successes of the first five years of SciDAC have demonstrated the power of using advanced computing to enable scientific discovery. One measure of this success could be found in the President’s State of the Union address in which President Bush identified ‘supercomputing’ as a major focus area of the American Competitiveness Initiative. Funds were provided in the FY 2007 President’s Budget request to increase the size of the NERSC-5 procurement to between 100-150 teraflops, to upgrade the LCF Cray XT3 at Oak Ridge to 250 teraflops and acquire a 100 teraflop IBM BlueGene/P to establish the Leadership computing facility at Argonne. We believe that we are on a path to establish a petascale computing resource for open science by 2009. We must develop software tools, packages, and libraries as well as the scientific application software that will scale to hundreds of thousands of processors. Computer scientists from universities and the DOE’s national laboratories will be asked to collaborate on the development of the critical system software components such as compilers, light-weight operating systems and file systems. Standing up these large machines will not be business as usual for ASCR. We intend to develop a series of interconnected projects that identify cost, schedule, risks, and scope for the upgrades at the LCF at Oak Ridge, the establishment of the LCF at Argonne, and the development of the software to support these high-end computers. The critical first step in defining the scope of the project is to identify a set of early application codes for each leadership class computing facility. These codes will have access to the resources during the commissioning phase of the facility projects and will be part of the acceptance tests for the machines. Applications will be selected, in part, by breakthrough science, scalability, and

  20. Open Source Opens Doors: Repurposing Library Software to Facilitate Faculty Research and Collaboration

    Directory of Open Access Journals (Sweden)

    Sandra L. Stump

    2013-10-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Asked to convert a faculty-created Microsoft Word document of biblical references found within popular films into a searchable database for scholars, the Albright College library staff helped create a multi-access database called Bible in the Reel World. The database relied on student workers for inputting data, used MARC standard formatting for future portability, and encouraged interactive feedback, enabling scholars to submit comments and suggest additional films and references. Using the open source integrated library system Koha, MarcEdit software, and free record exporting from IMDb, library staff created a fully-searchable database for researchers and scholars to examine the use of scripture in popular film.

  1. Opening Doors or Slamming Them Shut? Online Learning Practices and Students with Disabilities

    Directory of Open Access Journals (Sweden)

    Sheryl Burgstahler

    2015-12-01

    Full Text Available Online learning has the potential to open doors to education for everyone who has access to the technology required to participate. Or does it? When it comes to social inclusion in online learning, who are the “haves” and who are the “have-nots?” Some online learning practices erect barriers to individuals with disabilities—uncaptioned videos are not accessible to students who are deaf, content presented only within graphic images is not accessible to individuals who are blind, unorganized content cluttered on a page creates barriers to some students with learning disabilities and attention deficits, web pages that require the use of a mouse are inaccessible to those who cannot operate a mouse. This article explores the question, “What online learning practices make social inclusion possible for individuals with disabilities?” The author answers this question with lessons learned from her own teaching experiences as well as those presented in research and practice literature. She also shares overall characteristics of distance learning programs that promote the social inclusion of students with disabilities in their courses. The author points out how making courses welcoming to, accessible to, and usable by individuals with disabilities may promote the social inclusion of other students as well. She recommends further dissemination and future research regarding inclusive practices in online learning.

  2. The Midterm Surgical Outcome of Modified Expansive Open-Door Laminoplasty

    Directory of Open Access Journals (Sweden)

    Kuang-Ting Yeh

    2016-01-01

    Full Text Available Laminoplasty is a standard technique for treating patients with multilevel cervical spondylotic myelopathy. Modified expansive open-door laminoplasty (MEOLP preserves the unilateral paraspinal musculature and nuchal ligament and prevents facet joint violation. The purpose of this study was to elucidate the midterm surgical outcomes of this less invasive technique. We retrospectively recruited 65 consecutive patients who underwent MEOLP at our institution in 2011 with at least 4 years of follow-up. Clinical conditions were evaluated by examining neck disability index, Japanese Orthopaedic Association (JOA, Nurick scale, and axial neck pain visual analog scale scores. Sagittal alignment of the cervical spine was assessed using serial lateral static and dynamic radiographs. Clinical and radiographic outcomes revealed significant recovery at the first postoperative year and still exhibited gradual improvement 1–4 years after surgery. The mean JOA recovery rate was 82.3% and 85% range of motion was observed at the final follow-up. None of the patients experienced aggravated or severe neck pain 1 year after surgery or showed complications of temporary C5 nerve palsy and lamina reclosure by the final follow-up. As a less invasive method for reducing surgical dissection by using various modifications, MEOLP yielded satisfactory midterm outcomes.

  3. Opening Doors or Slamming Them Shut? Online Learning Practices and Students with Disabilities

    Directory of Open Access Journals (Sweden)

    Sheryl Burgstahler

    2015-12-01

    Full Text Available Online learning has the potential to open doors to education for everyone who has access to the technology required to participate. Or does it? When it comes to social inclusion in online learning, who are the “haves” and who are the “have-nots?” Some online learning practices erect barriers to individuals with disabilities—uncaptioned videos are not accessible to students who are deaf, content presented only within graphic images is not accessible to individuals who are blind, unorganized content cluttered on a page creates barriers to some students with learning disabilities and attention deficits, web pages that require the use of a mouse are inaccessible to those who cannot operate a mouse. This article explores the question, “What online learning practices make social inclusion possible for individuals with disabilities?” The author answers this question with lessons learned from her own teaching experiences as well as those presented in research and practice literature. She also shares overall characteristics of distance learning programs that promote the social inclusion of students with disabilities in their courses. The author points out how making courses welcoming to, accessible to, and usable by individuals with disabilities may promote the social inclusion of other students as well. She recommends further dissemination and future research regarding inclusive practices in online learning.

  4. Autonomous urban reconnaissance ingress system (AURIS): providing a tactically relevant autonomous door-opening kit for unmanned ground vehicles

    Science.gov (United States)

    Shane, David J.; Rufo, Michael A.; Berkemeier, Matthew D.; Alberts, Joel A.

    2012-06-01

    The Autonomous Urban Reconnaissance Ingress System (AURIS™) addresses a significant limitation of current military and first responder robotics technology: the inability of reconnaissance robots to open doors. Leveraging user testing as a baseline, the program has derived specifications necessary for military personnel to open doors with fielded UGVs (Unmanned Ground Vehicles), and evaluates the technology's impact on operational mission areas: duration, timing, and user patience in developing a tactically relevant, safe, and effective system. Funding is provided through the US ARMY Tank Automotive Research, Development and Engineering Center (TARDEC) and the project represents a leap forward in perception, autonomy, robotic implements, and coordinated payload operation in UGVs. This paper describes high level details of specification generation, status of the last phase of development, an advanced view of the system autonomy capability, and a short look ahead towards the ongoing work on this compelling and important technology.

  5. Opening the door to the development of novel Abl kinase inhibitors.

    Science.gov (United States)

    Bezerra Morais, Pedro Alves; Daltoé, Renata Dalmaschio; Paula, Heberth de

    2016-10-24

    The discovery of the importance of kinase activity and its relationship to the emergence and proliferation of cancer cells, due to changes in normal physiology, opened a remarkable pathway for the treatment of chronic myelogenous leukemia through intense search of drug candidates. Six Abl kinase inhibitors have received the US FDA approval as chronic myelogenous leukemia treatment, and continuous efforts in obtaining new, more effective and selective molecules are being carried out. Herein we discuss the mechanisms of Abl inhibition, structural features and ligand/protein interactions that are important for the design of new Abl kinase inhibitors. This review provides a broad overview of binding mode predictions, through molecular docking, which can be an approach to discover novel Abl kinase inhibitors.

  6. Biomechanics of open-door laminoplasty with and without preservation of posterior structures.

    Science.gov (United States)

    Healy, Andrew T; Lubelski, Daniel; West, James L; Mageswaran, Prasath; Colbrunn, Robb; Mroz, Thomas E

    2016-05-01

    OBJECTIVE Cervical open-door laminoplasty (ODL) is designed to decompress the spinal cord, maintain motion, and prevent postlaminectomy kyphosis. Many traditional laminoplasty techniques involve disruption of the posterior ligamentous structures, most notably the C7-T1 supraspinous ligament and interspinales muscle complex (intraspinous and supraspinous ligaments [ISLs]). METHODS Eight human cervical cadaveric specimens (C2-T1) were used to investigate the subaxial kinematics following ODL with varying degrees of posterior element disruption. Ligamentous integrity was preserved and specimens were tested utilizing force control in flexion-extension (FE), lateral bending (LB), and axial rotation (AR) in the native state, and following 1) C3-7 ODL, 2) ODL with terminal ISL resection, 3) ODL with C3-7 spinous process resection, and 4) C3-7 laminectomy. Range of motion (ROM) was measured across C2-T1, "global," and at the segmental level. RESULTS Compared with ODL, sectioning the terminal ISLs resulted in global ROM increases by 7.9% in FE, 2.4% in LB, and 5.6% in AR (p > 0.05), whereas laminectomy increased global ROM by 36.0% in FE (p = 0.002) and a 26.3% increase in AR ROM (p = 0.01). When considering segmental ROM, resection of the terminal ISLs increased ROM in FE by 36.5% at C2-3 (p = 0.019) and 25.4% at C7-T1 (p > 0.05). Segmental increases following C3-7 spinous process resection averaged less than 3% per level, compared with up to 40% increases in ROM per level after laminectomy. CONCLUSIONS Laminectomy resulted in the greatest increase in global cervical ROM. Resection of the ISLs at C2-3 and C7-T1 increased segmental ROM at these specific levels to a similar extent that laminectomy increased ROM at each cervical level. This segmental ROM may contribute to pain or postprocedural deformity and highlights the importance of the ISLs at the terminal ends of the ODL.

  7. The ICTJA-CSIC Science Week 2016: an open door to Earth Sciences for secondary education students

    Science.gov (United States)

    Cortes-Picas, Jordi; Diaz, Jordi; Fernandez-Turiel, Jose-Luis; Garcia-Castellanos, Daniel; Geyer, Adelina; Jurado, Maria-Jose; Montoya, Encarni; Rejas Alejos, Marta; Sánchez-Pastor, Pilar; Valverde-Perez, Angel

    2017-04-01

    The Science Week is one of the main scientific outreach events every year in Spain. The Institute of Earth Sciences Jaume Almera of CSIC (ICTJA-CSIC) participates in it since many years ago, opening its doors and proposing several activities in which it is shown what kind of multidisciplinary research is being developed at the Institute and in Geosciences. The activities,developed as workshops, are designed and conducted by scientific and technical personnel of the centre, who participates in the Science Week voluntarily. The activities proposed by the ICTJA-CSIC staff are designed for a target audience composed by secondary school students (12-18 years). The ICTJA-CSIC joined Science Week 2016 in the framework of the activity entitled "What we investigate in Earth Sciences?". The aim is to show to the society what is being investigated in the ICTJA-CSIC. In addition, it is intended, with the contact and interaction between the public and the institute researchers, to increase the interest in scientific activity and, if possible, to generate new vocations in the field of the Earth Sciences among secondary school pupils. We show in this communication the experience of the Science Week 2016 at the ICTJA-CSIC, carried out with the effort and commitment of the of the Institute's personnel with the outreach of Earth Sciences research. Between November 14th and 19th 2016, more than 100 students from four secondary schools from Barcelona area visited the Institute and took part in the Science Week. A total of six interactive workshops were prepared showing different features of seismology, geophysical borehole logging, analog and digital modelling, paleoecology, volcanology and geochemistry. As a novelty, this year a new workshop based on an augmented reality sandbox was offered to show and to simulate the processes of creation and evolution of the topographic relief. In addition, within the workshop dedicated to geophysical borehole logging, six exact replicates of

  8. A Kernel for Open Source Drug Discovery in Tropical Diseases

    OpenAIRE

    Leticia Ortí; Carbajo, Rodrigo J.; Ursula Pieper; Narayanan Eswar; Maurer, Stephen M.; Rai, Arti K.; Ginger Taylor; Todd, Matthew H; Antonio Pineda-Lucena; Andrej Sali; Marti-Renom, Marc A.

    2009-01-01

    BACKGROUND: Conventional patent-based drug development incentives work badly for the developing world, where commercial markets are usually small to non-existent. For this reason, the past decade has seen extensive experimentation with alternative R&D institutions ranging from private-public partnerships to development prizes. Despite extensive discussion, however, one of the most promising avenues-open source drug discovery-has remained elusive. We argue that the stumbling block has been the...

  9. Discovery and Reuse of Open Datasets: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Sara

    2016-07-01

    Full Text Available Objective: This article analyzes twenty cited or downloaded datasets and the repositories that house them, in order to produce insights that can be used by academic libraries to encourage discovery and reuse of research data in institutional repositories. Methods: Using Thomson Reuters’ Data Citation Index and repository download statistics, we identified twenty cited/downloaded datasets. We documented the characteristics of the cited/downloaded datasets and their corresponding repositories in a self-designed rubric. The rubric includes six major categories: basic information; funding agency and journal information; linking and sharing; factors to encourage reuse; repository characteristics; and data description. Results: Our small-scale study suggests that cited/downloaded datasets generally comply with basic recommendations for facilitating reuse: data are documented well; formatted for use with a variety of software; and shared in established, open access repositories. Three significant factors also appear to contribute to dataset discovery: publishing in discipline-specific repositories; indexing in more than one location on the web; and using persistent identifiers. The cited/downloaded datasets in our analysis came from a few specific disciplines, and tended to be funded by agencies with data publication mandates. Conclusions: The results of this exploratory research provide insights that can inform academic librarians as they work to encourage discovery and reuse of institutional datasets. Our analysis also suggests areas in which academic librarians can target open data advocacy in their communities in order to begin to build open data success stories that will fuel future advocacy efforts.

  10. Open source drug discovery in practice: a case study.

    Directory of Open Access Journals (Sweden)

    Christine Årdal

    Full Text Available BACKGROUND: Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. METHODOLOGY/PRINCIPAL FINDINGS: A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD and The Synaptic Leap's Schistosomiasis project (TSLS. Data were gathered from four sources: interviews of participating members (n = 14, a survey of potential members (n = 61, an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. CONCLUSIONS/SIGNIFICANCE: Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high

  11. Open source drug discovery in practice: a case study.

    Science.gov (United States)

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success factors appear to be clearly

  12. Influence of hinge position on the effectiveness of open-door expansive laminoplasty for cervical spondylotic myelopathy

    Institute of Scientific and Technical Information of China (English)

    WAN Jun; XU Tian-tong; SHEN Qing-feng; LI Hui-nan; XIA Ying-peng

    2011-01-01

    Objective: To assess the influence of different hinge positions on clinical results of expansive open-door laminoplasty (EOLP) for cervical spondylotic myelopathy (CSM).Methods: A total of 102 CSM patients who underwent EOLP from February 2006 to February 2007 were enrolled in this randomized controlled trial. Using a random digits table,57 patients with the hinge located at the inner margin of the lateral mass were classified as wide-open group, while 45 patients with the hinge positioned at the lamina margin served as narrow-open group. All patients were observed over 24 months, and the clinical and radiological results were analyzed statistically.Results: There were no significant differences in operation duration, intraoperative bleeding volume, Japanese Orthopaedic Association (JOA) scores, cervical curvature index, range of motion and neural function recovery rate.The neural functions were satisfactorily improved after surgery in both groups, while the severity of axial symptoms was significantly lower in the narrow-open group than in the wide-open group (P=0.003). The incidence of C5 palsy in the wide-open group was higher than that in the narrowopen group (5.3% vs 0), even though the difference did not reach statistical significance (one tailed Fisher's exact test,P=0.17).Conclusions: Proper inward shift of the hinge can ensure effectiveness of surgical decompression, avoid an excessive backward shift of the spinal cord, decrease the incidence of C5 palsy and alleviate the severity of axial symptoms.

  13. Book Review: Opening Space Research: Dreams, Technology, and Scientific Discovery

    Science.gov (United States)

    Good, Gregory A.

    2012-05-01

    In Opening Space Research: Dreams, Technology, and Scientific Discovery, George Ludwig takes the reader behind the scenes of space exploration in the 1950s. The well-known episodes in this history—such as the stories of Sputnik, Laika the cosmodog, and the founding of NASA—are here placed in the rich context of the scientific and technical goals that motivated Ludwig and his fellow researchers. Ludwig relates the personal experiences of the many engineers, physicists, and university students who made possible humanity’s first ventures into space.

  14. Numerical Study on Effects of Door-Opening on Airflow Patterns and Dynamic Cross-Contamination in an ISO Class 5 Operating Room

    Institute of Scientific and Technical Information of China (English)

    DONG Shuyun; TU Guangbei; CAO Rongguang; YU Zhenfeng

    2009-01-01

    The contamination diffusion to the operating room when the door is open was simulated with a computational fluid dynamic (CFD) method,to give the extent of the contamination diffusion.The influence of the door-opening procedure was ignored since the door of the operating room is normally a sliding one.The flow field in the case of the 16 s course of opening the door was simulated.The simulated and the experimental results demonstrate that the extent of the contamination diffusion is around 1.5 m when there is no temperature difference between indoor and outdoor,and there is hardly any contamination diffusion when the temperature difference is 1 ℃.It can be concluded that the positive pressure difference in the operating room lost its function in preventing the contamination when the door is open.That the temperature of corridor is lower than that of operating room contributes to contamination control.Keeping 1 ℃ temperature difference between corridor and operating room and increasing positive pressure and air flow are suggested.It is more secure to set up an anteroom if persons come in or out of the operation room at the course of surgery.

  15. Simulation of Underwater Vehicle’s Cabin Door Opening Process%水下航行器舱门开启过程仿真

    Institute of Scientific and Technical Information of China (English)

    孙善春

    2014-01-01

    Aiming at the shape changes of the underwater vehicle at the cabin door opening, simulate hydrodynamics features of cabin door opening process. According to hydrodynamics feature of cabin door opening process, take hydrodynamics index as variation curve of vehicle dynamics equation index, simulate cabin door opening movement, then give the calculation process in detail. The simulation results show that the cabin door opening design is reasonable. When door is opening, the speed and attack angle decrease, but the changing amplitude of physical quantity is normally. The method will give reference for movement simulation when the underwater vehicle is changing in shape at movement.%针对水下航行器的舱门在开启过程中航行器外形会发生变化的情况,对航行器舱门开启过程的流体特性进行仿真分析。根据舱门开启过程的流体特性,将得到的流体系数作为航行器动力学方程参数的变化曲线,对舱门开启过程的运动进行了仿真,并给出详细的计算过程。仿真结果表明:该舱门开启过程设计合理,随着舱门的开启,虽然航行器的速度和攻角有所下降,但各物理量的变化幅度仍然在常规范围内,该方法为水下航行器存在外形变化时的运动仿真提供了思路。

  16. Profiles of and correlation between objective and subjective outcome assessments following open-door laminoplasty for cervical spondylotic myelopathy

    Institute of Scientific and Technical Information of China (English)

    Zhou Feifei; Zhang Yilong; Sun Yu; Zhang Fengshan; Pan Shengfa; Diao Yinze; Chen Xin

    2014-01-01

    Background Open-door laminoplasty is widely used in the treatment of cervical spondylotic myelopathy (CSM).This study aimed to investigate the profiles of and correlation between objective and subjective short-term outcome assessments after open-door laminoplasty for CSM.Methods We retrospectively analyzed surgical outcomes in 129 consecutive CSM patients who underwent open-door laminoplasty in Peking University Third Hospital from February 2008 to November 2011.Both objective and subjective assessments were evaluated before surgery,3 months after surgery,and 1 year after surgery.We then analyzed the profiles of and correlation between objective and subjective short-term outcomes.Results The Modified Japanese Orthopaedic Association (mJOA) score was significantly improved at 3 months (P<0.01) and 1 year (P<0.01) after surgery.Bivariate Logistic regression showed that sensory improvement contributed more to the recovery rate than motor function improvement at 3 months after surgery,while motor function contributed more to the recovery rate at 1 year after surgery.On the subjective assessment (the short form (SF)-36),there was no significant improvement at 3 months after surgery (P>0.05),while physical function (PF),role-physical (RP),and social function (SF) were notably improved at 1 year after surgery (P<O.01).Improved mJOA score correlated with improvements in PF,RP,bodily pain,general health (GH),vitality (VT),and SF (P<O.05) at 3 months after surgery; PF,GH,VT,and SF were associated with improved mJOA scores at 1 year after surgery.Conclusions Patients benefit from surgery by postoperative restitution of neurological function with early recovery of sensory function,followed by a gradual transition to motor function improvement.At the early stage of recovery,improvement in the mJOA score essentially correlated with improvements in the physical domains of the SF-36,while at the later stage,mJOA score improvement was associated with improvements in both

  17. A kernel for open source drug discovery in tropical diseases.

    Directory of Open Access Journals (Sweden)

    Leticia Ortí

    Full Text Available BACKGROUND: Conventional patent-based drug development incentives work badly for the developing world, where commercial markets are usually small to non-existent. For this reason, the past decade has seen extensive experimentation with alternative R&D institutions ranging from private-public partnerships to development prizes. Despite extensive discussion, however, one of the most promising avenues-open source drug discovery-has remained elusive. We argue that the stumbling block has been the absence of a critical mass of preexisting work that volunteers can improve through a series of granular contributions. Historically, open source software collaborations have almost never succeeded without such "kernels". METHODOLOGY/PRINCIPAL FINDINGS: HERE, WE USE A COMPUTATIONAL PIPELINE FOR: (i comparative structure modeling of target proteins, (ii predicting the localization of ligand binding sites on their surfaces, and (iii assessing the similarity of the predicted ligands to known drugs. Our kernel currently contains 143 and 297 protein targets from ten pathogen genomes that are predicted to bind a known drug or a molecule similar to a known drug, respectively. The kernel provides a source of potential drug targets and drug candidates around which an online open source community can nucleate. Using NMR spectroscopy, we have experimentally tested our predictions for two of these targets, confirming one and invalidating the other. CONCLUSIONS/SIGNIFICANCE: The TDI kernel, which is being offered under the Creative Commons attribution share-alike license for free and unrestricted use, can be accessed on the World Wide Web at http://www.tropicaldisease.org. We hope that the kernel will facilitate collaborative efforts towards the discovery of new drugs against parasites that cause tropical diseases.

  18. The application of the open pharmacological concepts triple store (open PHACTS to support drug discovery research.

    Directory of Open Access Journals (Sweden)

    Joseline Ratnam

    Full Text Available Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers used in different resources and the absence of a simple mechanism to link them, gathering and combining relevant, comprehensive information from diverse databases remains a challenge. The Open Pharmacological Concepts Triple Store (Open PHACTS is an Innovative Medicines Initiative project that uses semantic web technology approaches to enable scientists to easily access and process data from multiple sources to solve real-world drug discovery problems. The project draws together sources of publicly-available pharmacological, physicochemical and biomolecular data, represents it in a stable infrastructure and provides well-defined information exploration and retrieval methods. Here, we highlight the utility of this platform in conjunction with workflow tools to solve pharmacological research questions that require interoperability between target, compound, and pathway data. Use cases presented herein cover 1 the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2 the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB signaling pathway that have a relevance to disease and 3 the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design. The example workflows presented illustrate how the Open PHACTS Discovery Platform can be used to exploit existing knowledge and generate new hypotheses in the process of drug discovery.

  19. Open Drug Discovery Teams: A Chemistry Mobile App for Collaboration.

    Science.gov (United States)

    Ekins, Sean; Clark, Alex M; Williams, Antony J

    2012-08-01

    The Open Drug Discovery Teams (ODDT) project provides a mobile app primarily intended as a research topic aggregator of predominantly open science data collected from various sources on the internet. It exists to facilitate interdisciplinary teamwork and to relieve the user from data overload, delivering access to information that is highly relevant and focused on their topic areas of interest. Research topics include areas of chemistry and adjacent molecule-oriented biomedical sciences, with an emphasis on those which are most amenable to open research at present. These include rare and neglected diseases, and precompetitive and public-good initiatives such as green chemistry. The ODDT project uses a free mobile app as user entry point. The app has a magazine-like interface, and server-side infrastructure for hosting chemistry-related data as well as value added services. The project is open to participation from anyone and provides the ability for users to make annotations and assertions, thereby contributing to the collective value of the data to the engaged community. Much of the content is derived from public sources, but the platform is also amenable to commercial data input. The technology could also be readily used in-house by organizations as a research aggregator that could integrate internal and external science and discussion. The infrastructure for the app is currently based upon the Twitter API as a useful proof of concept for a real time source of publicly generated content. This could be extended further by accessing other APIs providing news and data feeds of relevance to a particular area of interest. As the project evolves, social networking features will be developed for organizing participants into teams, with various forms of communication and content management possible.

  20. OpenSearch technology for geospatial resources discovery

    Science.gov (United States)

    Papeschi, Fabrizio; Enrico, Boldrini; Mazzetti, Paolo

    2010-05-01

    In 2005, the term Web 2.0 has been coined by Tim O'Reilly to describe a quickly growing set of Web-based applications that share a common philosophy of "mutually maximizing collective intelligence and added value for each participant by formalized and dynamic information sharing". Around this same period, OpenSearch a new Web 2.0 technology, was developed. More properly, OpenSearch is a collection of technologies that allow publishing of search results in a format suitable for syndication and aggregation. It is a way for websites and search engines to publish search results in a standard and accessible format. Due to its strong impact on the way the Web is perceived by users and also due its relevance for businesses, Web 2.0 has attracted the attention of both mass media and the scientific community. This explosive growth in popularity of Web 2.0 technologies like OpenSearch, and practical applications of Service Oriented Architecture (SOA) resulted in an increased interest in similarities, convergence, and a potential synergy of these two concepts. SOA is considered as the philosophy of encapsulating application logic in services with a uniformly defined interface and making these publicly available via discovery mechanisms. Service consumers may then retrieve these services, compose and use them according to their current needs. A great degree of similarity between SOA and Web 2.0 may be leading to a convergence between the two paradigms. They also expose divergent elements, such as the Web 2.0 support to the human interaction in opposition to the typical SOA machine-to-machine interaction. According to these considerations, the Geospatial Information (GI) domain, is also moving first steps towards a new approach of data publishing and discovering, in particular taking advantage of the OpenSearch technology. A specific GI niche is represented by the OGC Catalog Service for Web (CSW) that is part of the OGC Web Services (OWS) specifications suite, which provides a

  1. 14 CFR 23.783 - Doors.

    Science.gov (United States)

    2010-01-01

    ... may be crowded against the door on the inside of the airplane. (2) If inward opening doors are used, there must be a means to prevent occupants from crowding against the door to the extent that would... the external door, for which the initial opening movement is not inward, is fully closed and...

  2. Full biological characterization of human pluripotent stem cells will open the door to translational research.

    Science.gov (United States)

    Kramer, Nina; Rosner, Margit; Kovacic, Boris; Hengstschläger, Markus

    2016-09-01

    Since the discovery of human embryonic stem cells (hESC) and human-induced pluripotent stem cells (hiPSC), great hopes were held for their therapeutic application including disease modeling, drug discovery screenings, toxicological screenings and regenerative therapy. hESC and hiPSC have the advantage of indefinite self-renewal, thereby generating an inexhaustible pool of cells with, e.g., specific genotype for developing putative treatments; they can differentiate into derivatives of all three germ layers enabling autologous transplantation, and via donor-selection they can express various genotypes of interest for better disease modeling. Furthermore, drug screenings and toxicological screenings in hESC and hiPSC are more pertinent to identify drugs or chemical compounds that are harmful for human, than a mouse model could predict. Despite continuing research in the wide field of therapeutic applications, further understanding of the underlying basic mechanisms of stem cell function is necessary. Here, we summarize current knowledge concerning pluripotency, self-renewal, apoptosis, motility, epithelial-to-mesenchymal transition and differentiation of pluripotent stem cells.

  3. Language Policy in Puerto Rico's Higher Education: Opening the Door for Translanguaging Practices

    Science.gov (United States)

    Carroll, Kevin S.; Mazak, Catherine M.

    2017-01-01

    This paper investigates the relationship between meso university language policies in Puerto Rico and their micro instantiations in an undergraduate psychology classroom. We describe a typology of language policies used by 38 universities and campuses in Puerto Rico where their openness allows for flexible implementation of everyday micro policy.…

  4. Opening Spaces of Academic Culture: Doors of Perception; Heaven and Hell

    Science.gov (United States)

    Habel, Chad; Whitman, Kirsty

    2016-01-01

    Academic culture is a distinct and unique field, and perhaps may best be conceptualised as a space. Although access to university has traditionally been restricted, recent efforts on a number of fronts have attempted to "open" the space of the academy. In particular, enabling programmes such as Preparatory Programs and Foundation Courses…

  5. Language Policy in Puerto Rico's Higher Education: Opening the Door for Translanguaging Practices

    Science.gov (United States)

    Carroll, Kevin S.; Mazak, Catherine M.

    2017-01-01

    This paper investigates the relationship between meso university language policies in Puerto Rico and their micro instantiations in an undergraduate psychology classroom. We describe a typology of language policies used by 38 universities and campuses in Puerto Rico where their openness allows for flexible implementation of everyday micro policy.…

  6. Discussion Design of Mechanical Opening Door Device%一种机械式开门装置设计的探讨

    Institute of Scientific and Technical Information of China (English)

    吕俊

    2012-01-01

    机械开门装置因其具备良好的耐用性和可靠性等特点而被广泛地使用在工程领域中。介绍的一种机械开门装置采用操纵软轴配备连杆机构的结构模式,可作为矿井提升机结构设计的参考。该装置结构简单、操纵灵活,可确保门扇的安全开闭。%The mechanical door operator is widely used in engineering industry with the features of good durability and reliability. The mechanical door operator which is introduced adopts the structure model of manipulation soft bearing with linkage mode, suitable for mine hoist. The device structure is simple, flexible operation, to ensure the safety door open of hoist.

  7. New customizable phased array UT instrument opens door for furthering research and better industrial implementation

    Science.gov (United States)

    Dao, Gavin; Ginzel, Robert

    2014-02-01

    Phased array UT as an inspection technique in itself continues to gain wide acceptance. However, there is much room for improvement in terms of implementation of Phased Array (PA) technology for every unique NDT application across several industries (e.g. oil and petroleum, nuclear and power generation, steel manufacturing, etc.). Having full control of the phased array instrument and customizing a software solution is necessary for more seamless and efficient inspections, from setting the PA parameters, collecting data and reporting, to the final analysis. NDT researchers and academics also need a flexible and open platform to be able to control various aspects of the phased array process. A high performance instrument with advanced PA features, faster data rates, a smaller form factor, and capability to adapt to specific applications, will be discussed.

  8. New customizable phased array UT instrument opens door for furthering research and better industrial implementation

    Energy Technology Data Exchange (ETDEWEB)

    Dao, Gavin [Advanced OEM Solutions, 8044 Montgomery Road 700, Cincinnati OH 45236 (United States); Ginzel, Robert [Eclipse Scientific, 97 Randall, Waterloo, Ontario N2V 1C5 (Canada)

    2014-02-18

    Phased array UT as an inspection technique in itself continues to gain wide acceptance. However, there is much room for improvement in terms of implementation of Phased Array (PA) technology for every unique NDT application across several industries (e.g. oil and petroleum, nuclear and power generation, steel manufacturing, etc.). Having full control of the phased array instrument and customizing a software solution is necessary for more seamless and efficient inspections, from setting the PA parameters, collecting data and reporting, to the final analysis. NDT researchers and academics also need a flexible and open platform to be able to control various aspects of the phased array process. A high performance instrument with advanced PA features, faster data rates, a smaller form factor, and capability to adapt to specific applications, will be discussed.

  9. An open door for illegal trade: online sale of Strombocactus disciformis (Cactaceae

    Directory of Open Access Journals (Sweden)

    Vania R. Olmos-Lau

    2016-09-01

    Full Text Available Online trade of CITES listed species has become a persistent threat which is difficult to measure and control. The use of online markets is growing day by the day as technology becomes more available and familiar to people of all ages and interests. Species trade can now be propagated remotely hardly without any real human interaction. We develop a quick-easy method to assess the online availability of the genus Strombocactus, a highly collectible cactus, to understand the real magnitude of this new form of threat and the possible menace it could be for these Mexican cacti. We used the Google.com site to do an online search in four languages (Spanish, English, French and German for the offer of adult plants or seeds. We found specimens and seeds available in major online markets like ebay, amazon, cactusplaza.com and mercado libre. Plant price range from €10.00 to €30.00 plus shipping and handling. The plants were also offered in local online stores in countries like the USA, France, Germany, Australia, Czech Republic, the United Kingdom, and others; some sellers claim they have no obstacles for “shipping across countries” and others openly declare the natural localities where seeds were extracted. Only a minority of these online stores openly stated that the cacti were obtained from CITES registered nurseries or that the cacti were grown through propagules or seeds. Our method is easily transferable to estimate the illegal market for any species. There is an active online trade of Strombocactus species and other species listed in CITES without the necessary documentation. Compliance or other regulation mechanisms are needed in order to promote species conservation.

  10. Laparoscopically Assisted Proximal Gastrectomy with Esophagogastrostomy Using a Novel "Open-Door" Technique : LAPG with Novel Reconstruction.

    Science.gov (United States)

    Hosoda, Kei; Yamashita, Keishi; Moriya, Hiromitsu; Mieno, Hiroaki; Ema, Akira; Washio, Marie; Watanabe, Masahiko

    2016-12-26

    Laparoscopy-assisted proximal gastrectomy (LAPG) with esophagogastrostomy using a novel "open-door" technique was introduced recently, with the aim of preventing gastroesophageal reflux. However, quantitate assessment of gastroesophageal reflux after this surgery has not been performed till date. The aims of the current study were to investigate the safety and feasibility of this operation and to elucidate the postoperative reflux status. Twenty consecutive patients (18 men) with (y)cStage I gastric cancer in the upper third of the stomach who underwent LAPG at Kitasato University Hospital from May 2015 through September 2016 were retrospectively reviewed. We performed 24-h impedance-pH monitoring 3 months after surgery for the first eight patients and analyzed the postoperative reflux status. Median operation time was 333 min, while median anastomotic time was 81 min. None of the 20 patients experienced anastomotic leakage while two patients experienced anastomotic stricture requiring endoscopic balloon dilatation. No patient experienced heartburn without antacid drugs. During the 24-h impedance-pH monitoring, all but one patient had normal gastroesophageal acid reflux with the acid percent time of technique is a safe and feasible procedure for LAPG. The degree of gastroesophageal reflux was acceptable using this technique. Randomized controlled trials with long-term follow-ups are required to confirm that this technique would be superior to the others.

  11. Multivariate Analysis of Factors Associated With Axial Symptoms in Unilateral Expansive Open-Door Cervical Laminoplasty With Miniplate Fixation.

    Science.gov (United States)

    Chen, Hua; Liu, Hao; Deng, Yuxiao; Gong, Quan; Li, Tao; Song, Yueming

    2016-01-01

    Retrospective case-control study.Unilateral expansive open-door cervical laminoplasty with miniplate fixation is an efficient and increasing popular surgery for multilevel cervical spondylotic myelopathy. Axial symptoms are the most frequent complaints after cervical laminoplasty. But the mechanisms have not been fully clarified yet.The objective of this study is to compare the clinical and radiologic data between patients with or without axial symptoms and to investigate the factors associated with axial symptoms by multivariate analysis in cervical laminoplasty with miniplate fixation.A total of 129 patients who underwent cervical laminoplasty with miniplate fixation were comprised from August 2009 to March 2014. Patients were grouped according to whether they suffered from postoperative axial symptoms (PA) or not (NA). The clinical data including gender, age, duration of symptoms, diagnosis type, medical comorbidity, operative level, blood loss, operative time, pre- and post-Japanese Orthopedic Association (JOA) score, JOA recovery rates, and other complications were recorded. The radiologic data including cervical canal diameter, C2-7 Cobb angle, cervical range of motion (ROM), cross-sectional area, open angle, hinge union, and facet joint destroyed would be measured according to X-ray plain and CT scan images. The univariate analysis and multivariate logistic regression analysis were performed.There were 39 patients in PA group and 90 patients in NA group. Both groups gained significant JOA improvement postoperatively (P  0.05). The multivariate analysis showed that the negative change of cervical ROM (OR = 1.062, P = 0.047) and facet joints destroyed (OR = 0.661, P = 0.024) were related to axial symptoms.The change of cervical ROM and facet joints destroyed by miniscrews might be associated with axial symptoms after cervical laminoplasty with miniplate fixation. Cervical spine surgeons should carefully operate to decrease the injury of

  12. Abriendo puertas: conociendo a un celiaco Opening the Doors: Getting to know a celiac

    Directory of Open Access Journals (Sweden)

    María del Mar Ferre Rovira

    2010-12-01

    Full Text Available Justificación: La enfermedad celiaca o celiaquía es una intolerancia al gluten, afecta a cualquier grupo étnico o región, afectando a todas la dimensiones de la vida de los que la padecen. El tratamiento se centra, únicamente, en tomar una dieta sin gluten de por vida. Teniendo en cuenta que el trigo es el cereal de consumo mayoritario en países occidentales, adherirse a esta dieta puede ser realmente dificultoso. Objetivos: Conocer cómo afecta el seguimiento de la dieta sin gluten en la vida cotidiana del celiaco para mejorar su calidad de vida. Diseño: Estudio de caso. Metodología: Entrevistas abiertas semiestructuradas al paciente celiaco y a su entorno más cercano (madre y amigos, así como al enfermero y al trabajador social de su Centro de Salud. Resultados-conclusiones: El seguimiento de la dieta sin gluten afecta tanto a la dimensión personal, familiar y social y económica de la persona celiaca.Background: Celiac disease is an intolerance to gluten, that can affect any ethnicgroup in any region, as well as all aspects of the lives of those who suffer from it. The treatment for this pathology focuses solely on a gluten-free diet for life. Bearing in mind that wheat is the most widely consumed cerealin Western countries, maintaining such a diet can be difficult. Objectives: To learn how a life-long, gluten-free diet daily affects those who suffer from celiac disease in order to be able to improve their quality of life. Design: A case study. Methodology: Conducting open, semi-structured interviews with a patient suffering from celiac disease and those closest to him (mother and friends, as well as with the male nurse and the social worker from his Health Centre. Results and conclusions: A gluten-free diet affects the personal, family and social and economic aspects of the life of an individual suffering from celiac disease.

  13. Common characteristics of open source software development and applicability for drug discovery: a systematic review.

    Science.gov (United States)

    Ardal, Christine; Alstadsæter, Annette; Røttingen, John-Arne

    2011-09-28

    Innovation through an open source model has proven to be successful for software development. This success has led many to speculate if open source can be applied to other industries with similar success. We attempt to provide an understanding of open source software development characteristics for researchers, business leaders and government officials who may be interested in utilizing open source innovation in other contexts and with an emphasis on drug discovery. A systematic review was performed by searching relevant, multidisciplinary databases to extract empirical research regarding the common characteristics and barriers of initiating and maintaining an open source software development project. Common characteristics to open source software development pertinent to open source drug discovery were extracted. The characteristics were then grouped into the areas of participant attraction, management of volunteers, control mechanisms, legal framework and physical constraints. Lastly, their applicability to drug discovery was examined. We believe that the open source model is viable for drug discovery, although it is unlikely that it will exactly follow the form used in software development. Hybrids will likely develop that suit the unique characteristics of drug discovery. We suggest potential motivations for organizations to join an open source drug discovery project. We also examine specific differences between software and medicines, specifically how the need for laboratories and physical goods will impact the model as well as the effect of patents.

  14. Electric Roller Door Opener of the New Industry Standard%电动卷门开门机新行业标准浅析

    Institute of Scientific and Technical Information of China (English)

    颜斐进

    2015-01-01

    最新颁布和实施的行业标准 JG/T411-2013《电动卷门开门机》,为国内首次制定电动卷门开门机行业标准,本文针对该行业标准对电动卷门开门机的定义、适用范围、要求及试验方法内容进行解读和分析探讨,阐述新标准对行业发展和生产的指导意义。%The promulgation and implementation of the lat-est industry standard JG/T 411-2013 electric roller door opener for the first time to develop electric roller doors open industry standards, aiming at the industry standard for electric rolling door opener definition, scope, requirements and test methods for interpretation and analysis of content to explore, elaborate new standards for the industry and the production of guidance.

  15. Open-door-Laminoplastie bei zervikaler Myelopathie mithilfe eines Titan-Miniplättchensystems (Arch-Laminoplastie: Erste klinische Erfahrungen

    Directory of Open Access Journals (Sweden)

    Burtscher J

    2009-01-01

    Full Text Available Der Autor berichtet von ersten klinischen Erfahrungen mit einer speziellen Laminoplastietechnik bei Patienten, die an spondylogener zervikaler Myelopathie leiden. Zwischen Juni 2007 und Februar 2009 wurden 20 Patienten mit zervikaler Myelopathie aufgrund einer mehrsegmentalen zervikalen Spondylose und Spinalkanalstenose mithilfe einer speziellen Open-door-Laminoplastietechnik operiert. Diese Technik nützt ein Titan-Miniplättchensystem, um die aufgeklappten Wirbelbögen zu fixieren. Der durchschnittliche postoperative Beobachtungszeitraum beträgt 9 Monate, das durchschnittliche Patientenalter 63 Jahre. Insgesamt wurden 68 Etagen laminoplastiert. Die Klinik der Patienten wurde mithilfe der modifizierten JOA-Skala beurteilt. Die klinische Evaluierung der zervikalen Myelopathie erfolgte vor sowie drei und sechs Monate nach der Operation. Insgesamt sind zwei Patientengruppen mit oben beschriebener Technik chirurgisch versorgt worden. Gruppe 1 umfasst 14 Patienten mit zervikaler Myelopathie ohne klinische und/oder radiologische Zeichen der Instabilität, normaler zervikaler Lordose oder nur relativer Streckstellung der Halswirbelsäule (HWS, aber ohne Kyphose. Gruppe 2 umfasst 6 Patienten, die im Rahmen einer geplanten ventro-dorsalen Operation zuerst laminoplastiert wurden. Im Beobachtungszeitraum ist von den 68 operierten Etagen bei 20 Patienten keines der verwendeten Titan-Miniplättchensysteme disloziert. Klinische Verbesserungen konnten bei allen Patienten nachgewiesen werden. Die Verbesserung der Klinik schwankt zwischen 2 (Minimum und 7 Score-Punkten (Maximum. Die durchschnittliche klinische Verbesserung liegt bei 4,3 Score-Punkten pro Patient. Vier Patienten erholten sich vollständig. Ein Patient aus Gruppe 1 beklagte nach Laminoplastie verstärkte Nackenschmerzen. In Gruppe 1 sind im postoperativen Beobachtungszeitraum keine klinischen und/oder radiologischen Hinweise für Instabilität und Fehlstellungen (Kyphosierung aufgetreten. Die

  16. Throwing Open the Doors

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China’s art galleries,museums and libraries are to be made admission-free for the public In two years,Chinese citizens will not have to pay to enter public art galleries,the Ministry of Culture and the Ministry of Finance jointly announced on February 10.

  17. These Doors Are Open!

    Science.gov (United States)

    Achinstein, Betty; Athanases, Steven Z.; Curry, Marnie W.; Ogawa, Rodney T.; de Oliveira, Luciana C.

    2013-01-01

    Lower-income students of color in California are often underserved, as evidenced by low-resourced schools, an achievement gap, and low college-going rates. Educators increasingly call for "community schools" that link schools with community members and agencies to promote educational achievement and to access communities as resources for…

  18. Open Knee: Open Source Modeling & Simulation to Enable Scientific Discovery and Clinical Care in Knee Biomechanics

    Science.gov (United States)

    Erdemir, Ahmet

    2016-01-01

    Virtual representations of the knee joint can provide clinicians, scientists, and engineers the tools to explore mechanical function of the knee and its tissue structures in health and disease. Modeling and simulation approaches such as finite element analysis also provide the possibility to understand the influence of surgical procedures and implants on joint stresses and tissue deformations. A large number of knee joint models are described in the biomechanics literature. However, freely accessible, customizable, and easy-to-use models are scarce. Availability of such models can accelerate clinical translation of simulations, where labor intensive reproduction of model development steps can be avoided. The interested parties can immediately utilize readily available models for scientific discovery and for clinical care. Motivated by this gap, this study aims to describe an open source and freely available finite element representation of the tibiofemoral joint, namely Open Knee, which includes detailed anatomical representation of the joint's major tissue structures, their nonlinear mechanical properties and interactions. Three use cases illustrate customization potential of the model, its predictive capacity, and its scientific and clinical utility: prediction of joint movements during passive flexion, examining the role of meniscectomy on contact mechanics and joint movements, and understanding anterior cruciate ligament mechanics. A summary of scientific and clinically directed studies conducted by other investigators are also provided. The utilization of this open source model by groups other than its developers emphasizes the premise of model sharing as an accelerator of simulation-based medicine. Finally, the imminent need to develop next generation knee models are noted. These are anticipated to incorporate individualized anatomy and tissue properties supported by specimen-specific joint mechanics data for evaluation, all acquired in vitro from varying age

  19. Open innovation in early drug discovery: roadmaps and roadblocks.

    Science.gov (United States)

    Reichman, Melvin; Simpson, Peter B

    2016-05-01

    Open innovation in pharmaceutical R&D evolved from a triple helix of convergent paradigm shifts in academic, industrial and government research sectors. The birth of the biotechnology sector catalyzed shifts in location dynamics that led to the first wave of open innovation in pharmaceutical R&D between big pharma and startup companies. The National Institutes of Health (NIH) Roadmap was a crucial inflection point that set the stage for a new wave of open innovation models between pharmaceutical companies and universities that have the potential to transform the pharmaceutical R&D landscape. We highlight the attributes of leading protected open innovation models that foster the sharing of proprietary small molecule collections by lowering the risk of premature escape of intellectual property, particularly structure-activity data.

  20. Open Access Could Transform Drug Discovery: A Case Study of JQ1.

    Science.gov (United States)

    Arshad, Zeeshaan; Smith, James; Roberts, Mackenna; Lee, Wen Hwa; Davies, Ben; Bure, Kim; Hollander, Georg A; Dopson, Sue; Bountra, Chas; Brindley, David

    2016-01-01

    The cost to develop a new drug from target discovery to market is a staggering $1.8 billion, largely due to the very high attrition rate of drug candidates and the lengthy transition times during development. Open access is an emerging model of open innovation that places no restriction on the use of information and has the potential to accelerate the development of new drugs. To date, no quantitative assessment has yet taken place to determine the effects and viability of open access on the process of drug translation. This need is addressed within this study. The literature and intellectual property landscapes of the drug candidate JQ1, which was made available on an open access basis when discovered, and conventionally developed equivalents that were not are compared using the Web of Science and Thomson Innovation software, respectively. Results demonstrate that openly sharing the JQ1 molecule led to a greater uptake by a wider and more multi-disciplinary research community. A comparative analysis of the patent landscapes for each candidate also found that the broader scientific diaspora of the publically released JQ1 data enhanced innovation, evidenced by a greater number of downstream patents filed in relation to JQ1. The authors' findings counter the notion that open access drug discovery would leak commercial intellectual property. On the contrary, JQ1 serves as a test case to evidence that open access drug discovery can be an economic model that potentially improves efficiency and cost of drug discovery and its subsequent commercialization.

  1. Enabling Open Research Data Discovery through a Recommender System

    Science.gov (United States)

    Devaraju, Anusuriya; Jayasinghe, Gaya; Klump, Jens; Hogan, Dominic

    2017-04-01

    Government agencies, universities, research and nonprofit organizations are increasingly publishing their datasets to promote transparency, induce new research and generate economic value through the development of new products or services. The datasets may be downloaded from various data portals (data repositories) which are general or domain-specific. The Registry of Research Data Repository (re3data.org) lists more than 2500 such data repositories from around the globe. Data portals allow keyword search and faceted navigation to facilitate discovery of research datasets. However, the volume and variety of datasets have made finding relevant datasets more difficult. Common dataset search mechanisms may be time consuming, may produce irrelevant results and are primarily suitable for users who are familiar with the general structure and contents of the respective database. Therefore, we need new approaches to support research data discovery. Recommender systems offer new possibilities for users to find datasets that are relevant to their research interests. This study presents a recommender system developed for the CSIRO Data Access Portal (DAP, http://data.csiro.au). The datasets hosted on the portal are diverse, published by researchers from 13 business units in the organisation. The goal of the study is not to replace the current search mechanisms on the data portal, but rather to extend the data discovery through an exploratory search, in this case by building a recommender system. We adopted a hybrid recommendation approach, comprising content-based filtering and item-item collaborative filtering. The content-based filtering computes similarities between datasets based on metadata such as title, keywords, descriptions, fields of research, location, contributors, etc. The collaborative filtering utilizes user search behaviour and download patterns derived from the server logs to determine similar datasets. Similarities above are then combined with different

  2. Open-access and Structured Data in Drug Discovery

    Directory of Open Access Journals (Sweden)

    Yixin Zhang

    2015-01-01

    Full Text Available A data journal in the biomedical field is an innovative and interesting task with potential benefits to the scientific society, the pharmaceutical and biotechnology industrials, as well as the medical institutions and authorities. It can serve as a source to stimulate, using computational modeling and bioinformatics, the bridging of biomedicine and basic biology researches and connecting of pharmaceutical and biotechnology industrials with academy. In the era of various high throughput technologies and big data, it could become a powerful driving force to combine expertise to understand the complexity of life and to catalyze new innovative therapeutics and diagnosis. The developments of various high-throughput and/or high-content drug-screening techniques are aiming not only to probe a large number of chemical compounds, but also to obtain deep insights into the molecule/molecule interaction associated with the diversity of chemical space, the structure-activity relationship, as well as the pharmacological mechanism. Moreover, the cell-based drug-screening approaches can also shed new light on the dynamics and regulation of proteins and genes associated with various physiological and pathological states. To reflect on these developments, the BMDJ Editorial Board announed a Call for Papers for a special issue on datasets in the field of drug screening and discovery: http://biomed-data.eu/calls-for-papers/high-throughput-drug-screening

  3. Open access high throughput drug discovery in the public domain: a Mount Everest in the making.

    Science.gov (United States)

    Roy, Anuradha; McDonald, Peter R; Sittampalam, Sitta; Chaguturu, Rathnam

    2010-11-01

    High throughput screening (HTS) facilitates screening large numbers of compounds against a biochemical target of interest using validated biological or biophysical assays. In recent years, a significant number of drugs in clinical trails originated from HTS campaigns, validating HTS as a bona fide mechanism for hit finding. In the current drug discovery landscape, the pharmaceutical industry is embracing open innovation strategies with academia to maximize their research capabilities and to feed their drug discovery pipeline. The goals of academic research have therefore expanded from target identification and validation to probe discovery, chemical genomics, and compound library screening. This trend is reflected in the emergence of HTS centers in the public domain over the past decade, ranging in size from modestly equipped academic screening centers to well endowed Molecular Libraries Probe Centers Network (MLPCN) centers funded by the NIH Roadmap initiative. These centers facilitate a comprehensive approach to probe discovery in academia and utilize both classical and cutting-edge assay technologies for executing primary and secondary screening campaigns. The various facets of academic HTS centers as well as their implications on technology transfer and drug discovery are discussed, and a roadmap for successful drug discovery in the public domain is presented. New lead discovery against therapeutic targets, especially those involving the rare and neglected diseases, is indeed a Mount Everestonian size task, and requires diligent implementation of pharmaceutical industry's best practices for a successful outcome.

  4. Pre-open call auction and price discovery: Evidence from India

    Directory of Open Access Journals (Sweden)

    Rajesh Acharya

    2014-12-01

    Full Text Available Premier stock exchanges in India, viz. National Stock Exchange of India and Bombay Stock Exchange, introduced call auction in the pre-open session from 18 October 2010. This paper analyzes the impact of introduction of pre-open call auction on price discovery at the open. Empirical analysis is based on the familiar market model in an event study framework. The result shows a decline in the market model R2 for both opening and closing returns of stocks forming the part of call auction and also control sample. However, the magnitude of decline is less in the opening prices for the call auction stocks compared with control sample. Furthermore, analysis carried out using the second pass β and R2 regressions shows that the introduction of pre-open call auction does not have any significant impact on market quality. The findings of the study have implications for the future policy-making on the call auction framework.

  5. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

    Science.gov (United States)

    Perryman, Alexander L.; Horta Andrade, Carolina

    2016-01-01

    The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses. PMID:27764115

  6. Bovine viral diarrhea (BVD) can open the door to other problems, including reproductive, respiratory, and enteric disease

    Science.gov (United States)

    This is a review, written for a lay publication whose core audience in dairy producers. A brief history of bovine viral diarrhea (BVD) research is given as well as a review of recent research discoveries. National efforts to reduce antibiotic use have led to a greater emphasis on disease prevention ...

  7. Developing a framework for understanding and enabling open source drug discovery.

    Science.gov (United States)

    Allarakhia, Minna

    2010-08-01

    Open source drug discovery is increasingly being sought as a solution for managing product development complexities. Three drivers encouraging the use of the open source strategy include: upstream knowledge-based complexities associated with complementary assets, technological complexities given the scale of research and interdependencies between disciplines and downstream commercialization complexities. While literature currently discusses the need for open source strategies and their outcomes, we have reached a critical stage for a framework to cohesively understand how the drivers affect the open source models chosen as well as the governance strategies to ensure a successful outcome both in terms of knowledge access and product development. In this paper, an initial framework is designed with a focus on the type of participant as impacting the motivation to participate in an open source initiative, the objective of any open source strategy as impacting the structural model adopted and the structure of knowledge produced as impacting its management. It is anticipated that this framework should then provide an opportunity to develop governance rules for open source drug discovery initiatives.

  8. Open Access Target Validation Is a More Efficient Way to Accelerate Drug Discovery

    Science.gov (United States)

    Lee, Wen Hwa

    2015-01-01

    There is a scarcity of novel treatments to address many unmet medical needs. Industry and academia are finally coming to terms with the fact that the prevalent models and incentives for innovation in early stage drug discovery are failing to promote progress quickly enough. Here we will examine how an open model of precompetitive public–private research partnership is enabling efficient derisking and acceleration in the early stages of drug discovery, whilst also widening the range of communities participating in the process, such as patient and disease foundations. PMID:26042736

  9. Harvest: an open platform for developing web-based biomedical data discovery and reporting applications.

    Science.gov (United States)

    Pennington, Jeffrey W; Ruth, Byron; Italia, Michael J; Miller, Jeffrey; Wrazien, Stacey; Loutrel, Jennifer G; Crenshaw, E Bryan; White, Peter S

    2014-01-01

    Biomedical researchers share a common challenge of making complex data understandable and accessible as they seek inherent relationships between attributes in disparate data types. Data discovery in this context is limited by a lack of query systems that efficiently show relationships between individual variables, but without the need to navigate underlying data models. We have addressed this need by developing Harvest, an open-source framework of modular components, and using it for the rapid development and deployment of custom data discovery software applications. Harvest incorporates visualizations of highly dimensional data in a web-based interface that promotes rapid exploration and export of any type of biomedical information, without exposing researchers to underlying data models. We evaluated Harvest with two cases: clinical data from pediatric cardiology and demonstration data from the OpenMRS project. Harvest's architecture and public open-source code offer a set of rapid application development tools to build data discovery applications for domain-specific biomedical data repositories. All resources, including the OpenMRS demonstration, can be found at http://harvest.research.chop.edu.

  10. User Driven Development of Software Tools for Open Data Discovery and Exploration

    Science.gov (United States)

    Schlobinski, Sascha; Keppel, Frank; Dihe, Pascal; Boot, Gerben; Falkenroth, Esa

    2016-04-01

    The use of open data in research faces challenges not restricted to inherent properties such as data quality, resolution of open data sets. Often Open data is catalogued insufficiently or fragmented. Software tools that support the effective discovery including the assessment of the data's appropriateness for research have shortcomings such as the lack of essential functionalities like support for data provenance. We believe that one of the reasons is the neglect of real end users requirements in the development process of aforementioned software tools. In the context of the FP7 Switch-On project we have pro-actively engaged the relevant user user community to collaboratively develop a means to publish, find and bind open data relevant for hydrologic research. Implementing key concepts of data discovery and exploration we have used state of the art web technologies to provide an interactive software tool that is easy to use yet powerful enough to satisfy the data discovery and access requirements of the hydrological research community.

  11. Technology Opens Doors to Scientific Discovery, Portrait Unveiled of Former NLM Director Lindberg | NIH MedlinePlus the ...

    Science.gov (United States)

    ... my research into the social impact of the Internet back in the year 2000," she stated, "[the ... expand the publication and distribution of NIH MedlinePlus magazine, thousands and thousands more people will gain valuable, ...

  12. Virtual Visit to the ATLAS Control Room by Open Discovery Space webinar in Europe

    CERN Multimedia

    2013-01-01

    Open Discovery Space (ODS) is a socially-powered and multilingual open learning infrastructure to boost the adoption of eLearning resources. ODS brings millions of educational resources directly into school classrooms. A key part of planning engaging lessons is access to high-quality, trustworthy teaching content. The platform empowers teachers by helping them build their schools` digital libraries, join lively communities of peers to share best practices, and connect their schools virtually with the world`s best research centres, museums and libraries.

  13. Drug discovery applications for KNIME: an open source data mining platform.

    Science.gov (United States)

    Mazanetz, Michael P; Marmon, Robert J; Reisser, Catherine B T; Morao, Inaki

    2012-01-01

    Technological advances in high-throughput screening methods, combinatorial chemistry and the design of virtual libraries have evolved in the pursuit of challenging drug targets. Over the last two decades a vast amount of data has been generated within these fields and as a consequence data mining methods have been developed to extract key pieces of information from these large data pools. Much of this data is now available in the public domain. This has been helpful in the arena of drug discovery for both academic groups and for small to medium sized enterprises which previously would not have had access to such data resources. Commercial data mining software is sometimes prohibitively expensive and the alternate open source data mining software is gaining momentum in both academia and in industrial applications as the costs of research and development continue to rise. KNIME, the Konstanz Information Miner, has emerged as a leader in open source data mining tools. KNIME provides an integrated solution for the data mining requirements across the drug discovery pipeline through a visual assembly of data workflows drawing from an extensive repository of tools. This review will examine KNIME as an open source data mining tool and its applications in drug discovery.

  14. Long-term outcomes and prognostic analysis of modified open-door laminoplasty with lateral mass screw fusion in treatment of cervical spondylotic myelopathy

    Directory of Open Access Journals (Sweden)

    Su N

    2016-08-01

    Full Text Available Nan Su, Qi Fei, Bingqiang Wang, Dong Li, Jinjun Li, Hai Meng, Yong Yang, Ai Guo Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, People’s Republic of China Objectives: The purpose of the present study was to explore and analyze the long-term outcomes and factors that affect the prognosis of expansive open-door laminoplasty with lateral mass screw fusion in treatment of cervical spondylotic myelopathy (CSM. Methods: We retrospectively reviewed 49 patients with multilevel CSM who had undergone expansive open-door laminoplasty with lateral mass screws fixation and fusion in our hospital between February 2008 and February 2012. The average follow-up period was 4.6 years. The clinical data of patients, including age, sex, operation records, pre- and postoperation Japanese Orthopedic Association (JOA scores, cervical spine canal stenosis, and cervical curvature, were collected. Increased signal intensity (ISI on T2-weighted magnetic resonance imaging and ossification of the posterior longitudinal ligament were also observed. Paired t-test was used to analyze the treatment effectiveness and recovery of neuronal function. The prognostic factors were analyzed with multivariable linear regression model. Results: Forty-nine patients with CSM with a mean age of 59.44 years were enrolled in this study. The average of preoperative JOA score was 9.14±2.25, and postoperative JOA score was 15.31±1.73. There was significant difference between the pre- and postoperative JOA scores. The clinical improvement rate was 80.27%. On follow-up, five patients had complaints of neck and shoulder pain, but no evidence of C5 nerve palsy was found. Developmental cervical spine canal stenosis was present in all patients before surgery. Before surgery, ISI was observed in eight patients, while ossification of the posterior longitudinal ligament was found in 12 patients. The average of preoperative cervical

  15. Open drug discovery for the Zika virus [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Sean Ekins

    2016-02-01

    Full Text Available The Zika virus (ZIKV outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting points for drug discovery. Our response can build on previous efforts with virus outbreaks and lean heavily on work done on other flaviviruses such as dengue virus. We provide some suggestions of what might be possible and propose an open drug discovery effort that mobilizes global science efforts and provides leadership, which thus far has been lacking. We also provide a listing of potential resources and molecules that could be prioritized for testing as in vitro assays for ZIKV are developed. We propose also that in order to incentivize drug discovery, a neglected disease priority review voucher should be available to those who successfully develop an FDA approved treatment. Learning from the response to the ZIKV, the approaches to drug discovery used and the success and failures will be critical for future infectious disease outbreaks.

  16. Near Real Time Discovery and Conversion of Open Source Information to a Reward Matrix

    Directory of Open Access Journals (Sweden)

    Mark Rahmes

    2014-02-01

    Full Text Available We describe a system model for determining decision making strategies based upon the ability to perform data mining and pattern discovery utilizing open source information to automatically predict the likelihood of reactions to specific events or situational awareness from multiple information sources. Within this paper, we discuss the development of a method for determining actionable information to efficiently propitiate manpower, equipment assets, or propaganda responses to multiple application case scenario experiments. In our experiments, we have integrated open source information linking to human sentiment and manipulated other user selectable interlinking relative probabilities for different reactions to different events based upon current knowledge generated from the situation or event. The goal of our solution, called GlobalSite, is to deliver trustworthy decision making analysis which evaluates situations and potential impacts of such decisions through acquired open source information becoming a vital tool for continuing mission operations, analyst information or other decision making scenarios.

  17. Doors are opening at children’s day-care centre at Champs-Fréchets

    CERN Multimedia

    HR Department

    2008-01-01

    Opened in August 2008, this new centre offers day-care for children between the ages of 4 months and 4 years. Following an agreement with CERN, up to 20 places are reserved for members of the CERN personnel. The commune of Meyrin invites interested parents to come and visit the centre on Saturday 11 October 2008 from 10 a.m. to 4 p.m. Address : 69, rue des Lattes -1217 Meyrin Further information on the agreement with CERN: https://cern.ch/hr-services/Ben/Social/EVE.asp

  18. Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

    Science.gov (United States)

    Ballell, Lluís; Bates, Robert H; Young, Rob J; Alvarez-Gomez, Daniel; Alvarez-Ruiz, Emilio; Barroso, Vanessa; Blanco, Delia; Crespo, Benigno; Escribano, Jaime; González, Rubén; Lozano, Sonia; Huss, Sophie; Santos-Villarejo, Angel; Martín-Plaza, José Julio; Mendoza, Alfonso; Rebollo-Lopez, María José; Remuiñan-Blanco, Modesto; Lavandera, José Luis; Pérez-Herran, Esther; Gamo-Benito, Francisco Javier; García-Bustos, José Francisco; Barros, David; Castro, Julia P; Cammack, Nicholas

    2013-01-01

    With the aim of fuelling open-source, translational, early-stage drug discovery activities, the results of the recently completed antimycobacterial phenotypic screening campaign against Mycobacterium bovis BCG with hit confirmation in M. tuberculosis H37Rv were made publicly accessible. A set of 177 potent non-cytotoxic H37Rv hits was identified and will be made available to maximize the potential impact of the compounds toward a chemical genetics/proteomics exercise, while at the same time providing a plethora of potential starting points for new synthetic lead-generation activities. Two additional drug-discovery-relevant datasets are included: a) a drug-like property analysis reflecting the latest lead-like guidelines and b) an early lead-generation package of the most promising hits within the clusters identified. PMID:23307663

  19. Valuing the chances of survival of two distinct Eurasian lynx populations in Poland - do people want to keep the doors open?

    Science.gov (United States)

    Bartczak, Anna; Meyerhoff, Jürgen

    2013-11-15

    This study investigates individuals' preferences toward protection programs aimed at increasing the chances of survival of the two distinct Eurasian lynx populations in Poland. Those two groups, the Lowland and the Carpathian population, are exposed to different risks of extinction as they have different numbers, different-sized areas of occupation and different migration possibilities. Using a discrete choice experiment we examine the influence of the initial degree of endangerment on the allocation of respondents' funds. The results show that people prefer to invest in the conservation of the lynx population, which has initially lower chances of survival. The main driver of respondents' choices seems to be loss aversion rather than the urge to invest in an option with an expected higher outcome. This observation can be interpreted as people trying to keep all the options - doors - open by devoting more funds to the more vulnerable population than to the more stable one. Employing a scale-extended latent class model allowed us to detect segments among individuals showing different types of response behavior, including a form of serial non-participation.

  20. Open innovation for phenotypic drug discovery: The PD2 assay panel.

    Science.gov (United States)

    Lee, Jonathan A; Chu, Shaoyou; Willard, Francis S; Cox, Karen L; Sells Galvin, Rachelle J; Peery, Robert B; Oliver, Sarah E; Oler, Jennifer; Meredith, Tamika D; Heidler, Steven A; Gough, Wendy H; Husain, Saba; Palkowitz, Alan D; Moxham, Christopher M

    2011-07-01

    Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays interrogate multiple molecular targets and signaling pathways in a target "agnostic" fashion, which may reveal novel functions for well-studied proteins and discover new pathways of therapeutic value. Significantly, existing compound libraries may not have sufficient chemical diversity to fully leverage a phenotypic strategy. To address this issue, Eli Lilly and Company launched the Phenotypic Drug Discovery Initiative (PD(2)), a model of open innovation whereby external research groups can submit compounds for testing in a panel of Lilly phenotypic assays. This communication describes the statistical validation, operations, and initial screening results from the first PD(2) assay panel. Analysis of PD(2) submissions indicates that chemical diversity from open source collaborations complements internal sources. Screening results for the first 4691 compounds submitted to PD(2) have confirmed hit rates from 1.6% to 10%, with the majority of active compounds exhibiting acceptable potency and selectivity. Phenotypic lead generation strategies, in conjunction with novel chemical diversity obtained via open-source initiatives such as PD(2), may provide a means to identify compounds that modulate biology by novel mechanisms and expand the innovation potential of drug discovery.

  1. Two 'b's in the Beehive: The Discovery of the First Hot Jupiters in an Open Cluster

    CERN Document Server

    Quinn, S N; Latham, D W; Buchhave, L A; Cantrell, J R; Dahm, S E; Fürész, G; Szentgyorgyi, A H; Geary, J C; Torres, G; Bieryla, A; Berlind, P; Calkins, M C; Esquerdo, G A; Stefanik, R P

    2012-01-01

    We present the discovery of two giant planets orbiting stars in Praesepe (also known as the Beehive Cluster), the first known hot Jupiters in an open cluster. Pr0201b orbits a V=10.52 late F dwarf with a period of 4.4264 +/- 0.0070 days and has a minimum mass of 0.540 +/- 0.039 Mjup, and Pr0211b orbits a V=12.06 late G dwarf with a period of 2.1451 +/- 0.0012 days and has a minimum mass of 1.844 +/- 0.064 Mjup. Because they reside in a cluster, the ages of these planets are amongst the best-determined of any planet outside our own solar system. As we endeavor to learn more about the frequency and characteristics of planets, the environment in which most stars form -- open clusters like Praesepe -- may provide essential clues to this end. This discovery will allow, for the first time, a direct estimate of the short-period giant planet frequency in open clusters.

  2. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

    Science.gov (United States)

    Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Jürgen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Belen Cassera, Maria; Chih-Chien Cheng, Ken; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colón-López, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D’Alessandro, Sarah; Le Dang, Na; Delves, Michael; Du, Alan Y.; Duffy, Sandra; Abd El-Salam El-Sayed, Shimaa; Ferdig, Michael T.; Fernández Robledo, José A.; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Gamo, Francisco Javier; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; Hooft van Huijsduijnen, Rob; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Naranuntarat Jensen, Amornrat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Lafuente, Maria Jose; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinás, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Medina Vera, Iset; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Morais Rodrigues da Costa, Francielly; Müller, Joachim; Muriana, Arantza; Nakazawa Hewitt, Stephen; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Pham, Ngoc; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Abdo Rizk, Mohamed; Ruecker, Andrea; St. Onge, Robert; Salgado Ferreira, Rafaela; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Silva Villela, Filipe; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmüller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Voong Vinh, Phat; Vu, Hoan; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoît; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A.

    2016-01-01

    A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal

  3. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

    Directory of Open Access Journals (Sweden)

    Wesley C Van Voorhis

    2016-07-01

    Full Text Available A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34% of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments

  4. Stellar variability in open clusters . II. Discovery of a new period-luminosity relation in a class of fast-rotating pulsating stars in NGC 3766

    Science.gov (United States)

    Mowlavi, N.; Saesen, S.; Semaan, T.; Eggenberger, P.; Barblan, F.; Eyer, L.; Ekström, S.; Georgy, C.

    2016-10-01

    Context. Pulsating stars are windows to the physics of stars enabling us to see glimpses of their interior. Not all stars pulsate, however. On the main sequence, pulsating stars form an almost continuous sequence in brightness, except for a magnitude range between δ Scuti and slowly pulsating B stars. Against all expectations, 36 periodic variables were discovered in 2013 in this luminosity range in the open cluster NGC 3766, the origins of which was a mystery. Aims: We investigate the properties of those new variability class candidates in relation to their stellar rotation rates and stellar multiplicity. Methods: We took multi-epoch spectra over three consecutive nights using ESO's Very Large Telescope. Results: We find that the majority of the new variability class candidates are fast-rotating pulsators that obey a new period-luminosity relation. We argue that the new relation discovered here has a different physical origin to the period-luminosity relations observed for Cepheids. Conclusions: We anticipate that our discovery will boost the relatively new field of stellar pulsation in fast-rotating stars, will open new doors for asteroseismology, and will potentially offer a new tool to estimate stellar ages or cosmic distances. Based on observations made with the FLAMES instruments on the VLT/UT2 telescope at the Paranal Observatory, Chile, under the program ID 69.A-0123(A).

  5. Gamma-ray emitting narrow-line Seyfert 1 galaxies. New discoveries and open questions

    CERN Document Server

    D'Ammando, F; Finke, J; Larsson, J; Giroletti, M

    2013-01-01

    The discovery of gamma-ray emission from 5 radio-loud narrow-line Seyfert 1 galaxies revealed the presence of a possible emerging third class of AGNs with relativistic jets, in addition to blazars and radio galaxies. The existence of relativistic jets also in this subclass of Seyfert galaxies opened an unexplored research space for our knowledge of the radio-loud AGNs. Here, we discuss the radio-to-gamma-rays properties of the gamma-ray emitting narrow-line Seyfert 1 galaxies, also in comparison with the blazar scenario.

  6. Leveraging Crowdsourcing and Linked Open Data for Geoscience Data Sharing and Discovery

    Science.gov (United States)

    Narock, T. W.; Rozell, E. A.; Hitzler, P.; Arko, R. A.; Chandler, C. L.; Wilson, B. D.

    2013-12-01

    Data citation standards can form the basis for increased incentives, recognition, and rewards for scientists. Additionally, knowing which data were utilized in a particular publication can enhance discovery and reuse. Yet, a lack of data citation information in existing publications as well as ambiguities across datasets can limit the accuracy of automated linking approaches. We describe a crowdsourcing approach, based on Linked Open Data, in which AGU abstracts are linked to the data used in those presentations. We discuss our efforts to incentivize participants through promotion of their research, the role that the Semantic Web can play in this effort, and how this work differs from existing platforms such as Mendeley and ResearchGate. Further, we discuss the benefits and challenges of Linked Open Data as a technical solution including the role of provenance, trust, and computational reasoning.

  7. Plenario: An Open Data Discovery and Exploration Platform for Urban Science

    Energy Technology Data Exchange (ETDEWEB)

    Catlett, Charlie; Malik, Tanu; Goldstein, Brett J.; Giuffrida, Jonathan; Shao, Yetong; Panella, Alessandro; Eder, Derek; van Zanten, Eric; Mitchum, Robert; Thaler, Severin; Foster, Ian

    2014-12-01

    The past decade has seen the widespread release of open data concerning city services, conditions, and activities by government bodies and public institutions of all sizes. Hundreds of open data portals now host thousands of datasets of many different types. These new data sources represent enormous po- tential for improved understanding of urban dynamics and processes—and, ultimately, for more livable, efficient, and prosperous communities. However, those who seek to realize this potential quickly discover that discovering and applying those data relevant to any particular question can be extraordinarily dif- ficult, due to decentralized storage, heterogeneous formats, and poor documentation. In this context, we introduce Plenario, a platform designed to automating time-consuming tasks associated with the discovery, exploration, and application of open city data—and, in so doing, reduce barriers to data use for researchers, policymakers, service providers, journalists, and members of the general public. Key innovations include a geospatial data warehouse that allows data from many sources to be registered into a common spatial and temporal frame; simple and intuitive interfaces that permit rapid discovery and exploration of data subsets pertaining to a particular area and time, regardless of type and source; easy export of such data subsets for further analysis; a user-configurable data ingest framework for automated importing and periodic updating of new datasets into the data warehouse; cloud hosting for elastic scaling and rapid creation of new Plenario instances; and an open source implementation to enable community contributions. We describe here the architecture and implementation of the Plenario platform, discuss lessons learned from its use by several communities, and outline plans for future work.

  8. SESAME: opening doors through science

    CERN Multimedia

    Pauline Gagnon

    2012-01-01

    Two Pakistani scientists arrived at CERN on 2 February at the height of the cold snap. They will spend the coming year working in collaboration with CERN’s magnet experts, learning the technology and contributing to ongoing projects.   Sumera Yamin (left) and Khalid Mansoor Hassan (right) with quadrupole magnets in the I8 testing facility. Sumera Yamin, a physicist, and Khalid Mansoor Hassan, an electrical engineer, both from the National Centre for Physics in Islamabad, came to CERN under an agreement with Pakistan. “They started contributing right away, helping us design and build new magnets for the ALPHA experiment,” says Davide Tommasini, Head of the resistive magnet section. “They fitted right in, just like I had expected. It is amazing to see that all scientists share the same approach.” The two scientists will also contribute to some aspects of the magnet design and the technical specifications for the SESAME project, the Synchrotron-...

  9. Open the Door in Huajiadi

    Institute of Scientific and Technical Information of China (English)

    QiuZhijie

    2004-01-01

    The other day when Xiaogang asked me whether we should organize an exhibition about Huajiadi or not he did not seem quite sure.and neither did I give a definite answer.Then he started to introduce this idea with a voice of calm and objectivity.which sounded uncertain and remote in my large living room as if the idea were none of his business.

  10. Opening the Doors of History

    Institute of Scientific and Technical Information of China (English)

    WANG HAIRONG

    2011-01-01

    China is blessed with a long history,and for millenniums the people of China have used history as a mirror to learn from the past.An important part of the country's history,all the archives of the Communist Party of China (CPC) and the Central Government of the People's Republic of China (PRC) are housed in the Central Archives of China,also known as the State Archives Administration.

  11. Opening the Doors of History

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China’s Central Archives aspires to improve public access to information China is blessed with a long history,and for millenniums the people of China have used history as a mirror to learn from the past. An important part of the country’s history, all the archives of the Communist Party of China (CPC)

  12. Build Fences or Open Doors?

    Science.gov (United States)

    Kavanagh, John; Lancaster, Martin

    2008-01-01

    Across the country, the question of what to do about illegal immigrants is fodder for fierce debate. While officials in some states argue for tougher policies and, in many cases, deportation, more sympathetic voices urge compassion and amnesty. As a leading source of education for minority students, the nation's community colleges are at the…

  13. Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

    Science.gov (United States)

    Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

    2014-01-01

    The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

  14. Exploring open innovation with a patient focus in drug discovery: an evolving paradigm of patient engagement.

    Science.gov (United States)

    Allarakhia, Minna

    2015-06-01

    It is suggested in this article that patient engagement should occur further upstream during the drug discovery stage. 'Lead patients', namely those patients who are proactive with respect to their health, possess knowledge of their disease and resulting symptoms. They are also well informed about the conventional as well as non-conventional treatments for disease management; and so can provide a nuanced perspective to drug design. Understanding how patients view the management of their diseases and how they view the use of conventional versus non-conventional interventions is of imperative importance to researchers. Indeed, this can provide insight into how conventional treatments might be designed from the outset to encourage compliance and positive health outcomes. Consequently, a continuum of lead patient engagement is employed that focuses on drug discovery processes ranging from participative, informative to collaborative engagement. This article looks at a variety of open innovation models that are currently employed across this engagement spectrum. It is no longer sufficient for industry stakeholders to consider conventional therapies as the only mechanisms being sought after by patients. Without patient engagement, the industry risks being re-prioritized in terms of its role in the patient journey towards not only recovery of health, but also sustained health and wellness before disease onset.

  15. Open-access public-private partnerships to enable drug discovery--new approaches.

    Science.gov (United States)

    Müller, Susanne; Weigelt, Johan

    2010-03-01

    The productivity of the pharmaceutical industry, as assessed by the number of NMEs produced per US dollar spent in R&D, has been in steady decline during the past 40 years. This decline in productivity not only poses a significant challenge to the pharmaceutical industry, but also to society because of the importance of developing drugs for the treatment of unmet medical needs. The major challenge in progressing a new drug to the market is the successful completion of clinical trials. However, the failure rate of drugs entering trials has not decreased, despite various technological and scientific breakthroughs in recent decades, and despite intense target validation efforts. This lack of success suggests limitations in the fundamental understanding of target biology and human pharmacology. One contributing factor may be the traditional secrecy of the pharmaceutical sector, a characteristic that does not promote scientific discovery in an optimal manner. Access to broader knowledge relating to target biology and human pharmacology is difficult to obtain because interactions between researchers in industry and academia are typically restricted to closed collaborations in which the knowledge gained is confidential.However, open-access collaborative partnerships are gaining momentum in industry, and are also favored by funding agencies. Such open-access collaborations may be a powerful alternative to closed collaborations; the sharing of early-stage research data is expected to enable scientific discovery by engaging a broader section of the scientific community in the exploration of new findings. Potentially, the sharing of data could contribute to an increased understanding of biological processes and a decrease in the attrition of clinical programs.

  16. Accelerating target discovery using pre-competitive open science-patients need faster innovation more than anyone else.

    Science.gov (United States)

    Low, Eric; Bountra, Chas; Lee, Wen Hwa

    2016-01-01

    We are experiencing a new era enabled by unencumbered access to high quality data through the emergence of open science initiatives in the historically challenging area of early stage drug discovery. At the same time, many patient-centric organisations are taking matters into their own hands by participating in, enabling and funding research. Here we present the rationale behind the innovative partnership between the Structural Genomics Consortium (SGC)-an open, pre-competitive pre-clinical research consortium and the research-focused patient organisation Myeloma UK to create a new, comprehensive platform to accelerate the discovery and development of new treatments for multiple myeloma.

  17. Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

    Science.gov (United States)

    Duffy, Sandra; Sykes, Melissa L; Jones, Amy J; Shelper, Todd B; Simpson, Moana; Lang, Rebecca; Poulsen, Sally-Ann; Sleebs, Brad E; Avery, Vicky M

    2017-09-01

    Open-access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open-access Pathogen Box collection is comprised of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens. We tested the Pathogen Box against kinetoplastid parasites and malaria life cycle stages in vitro Consequently, chemical starting points for malaria, human African trypanosomiasis, Chagas disease, and leishmaniasis drug discovery efforts have been identified. Inclusive of this in vitro biological evaluation, outcomes from extensive literature reviews and database searches are provided. This information encompasses commercial availability, literature reference citations, other aliases and ChEMBL number with associated biological activity, where available. The release of this new data for the Pathogen Box collection into the public domain will aid the open-source model of drug discovery. Importantly, this will provide novel chemical starting points for drug discovery and target identification in tropical disease research. Copyright © 2017 Duffy et al.

  18. On Opening/Closing Synchronization of Train and Platform Doors%列车车门及站台屏蔽门的开/关门时序研究

    Institute of Scientific and Technical Information of China (English)

    金碧筠; 周巧莲

    2013-01-01

    在对列车车门及站台屏蔽门的开/关门工作原理进行研究的基础上,介绍了上海城市轨道交通列车车门及站台屏蔽门的开/关门整个过程的试验测试结果.最终确立了上海城市轨道交通列车车门及站台屏蔽门的开/关门延时时间范围:若需要现“开门时原则上列车客车车门和站台屏蔽门应同时启动,实际测试中车门不应比屏蔽门先启动,屏蔽门比车门先启动的时间不应大于1s”的要求,车门与屏蔽门的开门设定延时时间差控制在1.15~3.35 s之间.同理,关门时间差必须控制在0~3.35 s之间.%The opening/closing process of train and platform doors is summarized through site test,the general sequence of events for opening/closing of train and platform doors are illustrated.Based on the working principle,the specific delay period should be controlled within 1.15 s~3.35 s,requirements needed for the train and platform doors are identified to achieve synchronization in the opening/closing operations.

  19. A modified unilateral open-door miniscrew-plate fixation:a biomechanical study%新型改良单开门微型钛钉-钛板内固定的生物力学研究

    Institute of Scientific and Technical Information of China (English)

    刘帅; 雷伟; 吴子祥; 樊勇; 严亚波; 石磊; 刘达; 张扬

    2011-01-01

    Objective To evaluate the biomechanical performance of a modified miniscrew-plate fixation in the unilateral open-door cervical laminoplasty.Methods Eight specimens of cervical spine (C3-C7) were made from intact adult cadavers.After randomization into 2 groups, with 4 specimens and 20 vertebral segments in each group, the unilateral open-door cervical laminoplasty was performed in each cervical vertebra in both groups.In group A the modified miniscrew-plates were used while in group B the traditional miniscrew-plates were implanted.A MTS880 machine was used to test the maximal load of the reclosed open-door miniscrew-plate at each cervical vertebra, and the maximal load and energy of the completely closed open-door miniscrew-plate.Results In the reclosing process, the mean maximal load was 873.61 ±154.40 N in group A and 297.17 ± 133.41 N in group B.In the complete closing state, the mean maximal load was 812.98 ± 141.79 N in group A and 145.77 ±59.21 N in group B; the mean energy was 5.95 ±0.83 J in group A and 1.65 ± 0.70 J in group B.There were significant differences between the 2 groups ( P < 0.05 ) .Conclusion The modified miniscrew-plate can have better biomechanical performance than the traditional miniscrew-plate in simulated unilateral open-door cervical laminoplasty.%目的 探讨改良单开门微型钛钉-钛板内固定的生物力学特性.方法 选取8具无损伤的新鲜人尸体颈椎标本(C3-7),经分次处理后随机分为两组,每组4具标本20个节段:A组:于每个节段颈椎标本模拟单开门颈椎管扩大成形术,术中使用改良单开门微型钛钉-钛板固定;B组:每节段颈椎标本模拟同样手术操作,使用传统单开门钛钉-钛板(Centerpiece钉板)固定.应用MTS880生物材料实验机测试每个颈椎节段标本开门后再关门的最大负荷、完全关门时的负荷及功耗,并对两组结果进行比较.结果 再关门过程中A组和B组的最大负荷平均分别为(873.61±154.40)

  20. Open Support Platform for Environmental Research (OSPER) - tools for the discovery and exploitation of environmental data

    Science.gov (United States)

    Dawes, N. M.; Lehning, M.; Bavay, M.; Sarni, S.; Iosifescu, I.; Gwadera, R.; Scipion, D. E.; Blanchet, J.; Davison, A.; Berne, A.; Hurni, L.; Parlange, M. B.; Aberer, K.

    2012-12-01

    The Open Support Platform for Environmental Research (OSPER) has been launched to take forward key data management components developed under the Swiss Experiment platform project to achieve improved usability and a wider scope. With this project, we aim to connect users to data and their context, an area identified during SwissEx as having the greatest potential impact on the research community. OSPER has a clear focus on providing the technology for data storage, management and exploitation with a special focus on data interoperability and documentation. In this presentation, we will demonstrate the key aims of OSPER for the period 2012 - 2015. Inheriting the basic SwissEx functionality, OSPER provides an excellent method of making data accessible via their metadata. One of the biggest differences between the OSPER infrastructure and other data platforms is the level of interaction that one can have with the data and the level of integration with the analysis tools used in science. We wish to capitalise on this advantage by increasing this integration and working with environmental research projects to develop the tools that make a difference to their daily research. The new data infrastructure will serve the following purposes: ● Open documentation, archiving and discovery of datasets. ● Facilitation of data sharing and collaboration (especially inter-disciplinary) with data owner controlled access rights, particularly concentrating on providing as much contextual information as possible. ● Improvements in ease of data access and combination of data sources. ● Tools for data visualisation and statistical and numerical data analysis with a focus on spatial data and trends. Key areas identified for development during OSPER are: ● New infrastructure and content for current WebGIS-based data visualisation system to create a publicly available platform. ● Provision of data in standard formats using standard methods as well as the consumption of such data

  1. 论1950年代高等学校“向工农开门”的方针%On the Policy of Higher Education Institutions “Opening the Door to Workers and Peasants” in 1950s

    Institute of Scientific and Technical Information of China (English)

    彭厚文

    2015-01-01

    After the establishment of PRC,the CPC advanced the policy of“opening door to workers and peasants” in the education field,which mainly involved the higher education institutions “opening the door to workers and peasants”. The CPC mainly adopted two forceful measures to implement this policy———establishing People’ s University of China and opening wide-spread instant middle schools for workers and peasants. After 1955,this policy once changed into focusing on cultivating intel-lectuals among workers and peasants mainly through part-time education. After the Anti-Rightist campaign of 1957,the CPC emphasized higher education institutions “opening door to workers and farmers” again. This policy had played an active role in cultivating new China’ s first generation of new intellectual workers and peasants. However,there were also some negative fac-tors,such as the quality of education cannot be assured,injustice,distrust to intellectuals,too much dogmatism,etc.%新中国成立后中国共产党在教育领域提出的“向工农开门”方针,主要是高等学校“向工农开门”。中国共产党主要采取了两项强力措施———创办中国人民大学和普遍举办工农速成中学贯彻实施这一方针。1955年后,这一方针一度改变为强调培养工农知识分子以业余教育为主。1957年反右派斗争后,中国共产党又重新强调高等学校“向工农开门”。这一方针对于培养新中国第一代新型工农知识分子发挥了积极作用,但也存在着教育质量难以得到保证、不公平、对知识分子不信任、教条主义色彩浓厚等消极因素。

  2. Vee ziek door eikenprocessierups

    NARCIS (Netherlands)

    Spijker, J.H.

    2007-01-01

    In 2006 zijn er incidenteel ernstige problemen geweest met vee dat ingeschaard was langs eiken die zwaar waren aangetast door eikenprocessierups. Tot vele tientallen meters langs deze lanen bleek het gras niet geschikt voor dierlijke consumptie door de aanwezigheid van verwaaide nesten van deze rups

  3. Numerical Calcultion on Hydrodynamic Characteristic of UUV with Cabin Door Opened at Small Angle of Attack%舱门开启状态下UUV小攻角水动力特性数值模拟

    Institute of Scientific and Technical Information of China (English)

    刘立栋; 张宇文

    2012-01-01

    In order to master hydrodynamic characteristic of UUV whose cabin door is opened at small angle of attack,based on wind tunnel model experiment firstly, it is proved that numerical computation method used is accurate and effective;then the drag,lift and moment characteristic of UUV whose cabin door is opened are calculated numerically by this method,and the influence of load cabin and cabin door on the surface pressure distribution of UUV is analysed after cabin door is opened. The computation result shows that the high pressure difference between the front end and the back end of the load cabin results in a significant increase of the pressare drag of load cabin dragin UUV's, and the drag about zero angle of attack are not symmetrical,the main reason of which is that the pressure drag of load cabin increases with the increase of absolute value of angle of attack on the condition of negative angle of attack. Because of fluid block function of the average pressure on the canbin door's down surface is higher that the up one when the angle of attack is zero degree,so zero lift of UUV is positive,and zero lift angle of attack is about -3 degrees,besides zero moment is positive. Zero moment angle of attack is about -1 degrees.%为了掌握舱门开启状态下UUV小攻角水动力特性,首先基于风洞模型实验验证了所用数值计算方法的准确性与有效性,进而采用该方法对舱门开启状态UUV阻力、升力及力矩特性进行了数值模拟研究,分析了舱门开启后载荷舱及舱门对UUV表面压力分布的影响.计算结果表明,载荷舱前后端面形成的较大压力差,导致舱门开启状态UUV阻力显著提升,且阻力关于零攻角表现为不对称性,主要原因在于负攻角条件下载荷舱粘压阻力随攻角绝对值的增大而增大;由于载荷舱的流体阻滞作用,零攻角工况下舱门下表面平均压力高于上表面,UUV零攻角升力为正,零升力攻角约为-3.,

  4. PNEUMATIC - LOGIC SYNTHESIS OF BUS DOOR FROM ASPECT OF AUTOMATION

    Directory of Open Access Journals (Sweden)

    Slobodan Stefanovic

    2015-01-01

    Full Text Available The paper presents a logic synthesis procedure pneumatic control of the door of the bus for suburban traffic. Minimization of pneumatic control is determined graphically by Weitz – Carnot method. It also shows all pneumatic components belonging to installations used for opening and closing the door of the bus. Finally it is shown the basic maintenance of pneumatic system of the bus door.

  5. Open for collaboration: an academic platform for drug discovery and development at SciLifeLab.

    Science.gov (United States)

    Arvidsson, Per I; Sandberg, Kristian; Forsberg-Nilsson, Karin

    2016-10-01

    The Science for Life Laboratory Drug Discovery and Development (SciLifeLab DDD) platform reaches out to Swedish academia with an industry-standard infrastructure for academic drug discovery, supported by earmarked funds from the Swedish government. In this review, we describe the build-up and operation of the platform, and reflect on our first two years of operation, with the ambition to share learnings and best practice with academic drug discovery centers globally. We also discuss how the Swedish Teacher Exemption Law, an internationally unique aspect of the innovation system, has shaped the operation. Furthermore, we address how this investment in infrastructure and expertise can be utilized to facilitate international collaboration between academia and industry in the best interest of those ultimately benefiting the most from translational pharmaceutical research - the patients.

  6. Discovering Open Source Discovery: Using VuFind to Create MnPALS Plus

    Science.gov (United States)

    Digby, Todd; Elfstrand, Stephen

    2011-01-01

    The goal of having a robust discovery system is a priority of the libraries the authors serve (both work at the Minnesota State Colleges and Universities). Given the current fiscal situation facing public higher education in their state, the current commercial systems were not affordable for most of their libraries. They decided to implement and…

  7. Discovering Open Source Discovery: Using VuFind to Create MnPALS Plus

    Science.gov (United States)

    Digby, Todd; Elfstrand, Stephen

    2011-01-01

    The goal of having a robust discovery system is a priority of the libraries the authors serve (both work at the Minnesota State Colleges and Universities). Given the current fiscal situation facing public higher education in their state, the current commercial systems were not affordable for most of their libraries. They decided to implement and…

  8. Stop Sagging Doors.

    Science.gov (United States)

    Cronk, Bob

    2000-01-01

    Explains how continuous geared hinges can help prevent doors from pulling away from their frames and can last as long as 20 years with little maintenance. Descriptions of three main applications for continuous geared hinges are described. (GR)

  9. Web Strategies for the Curation and Discovery of Open Educational Resources

    Science.gov (United States)

    Rolfe, Vivien

    2016-01-01

    For those receiving funding from the UK HEFCE-funded Open Educational Resource Programme (2009-2012), the sustainability of project outputs was one of a number of essential goals. Our approach for the hosting and distribution of health and life science open educational resources (OER) was based on the utilisation of the WordPress.org blogging…

  10. WAC: Closing Doors or Opening Doors for Second Language Writers?

    Science.gov (United States)

    Cox, Michelle

    2011-01-01

    Written by a WAC program director and second language writing studies scholar, this article raises questions about how second language writers are faring in WAC programs and the extent to which the fields of second language writing and WAC are informed by each other's scholarship. In this article, Cox draws from her review of 26 journal articles…

  11. Blower door measurements - extended measuring methods; Blower Door-Messungen - erweiterte Messmethoden

    Energy Technology Data Exchange (ETDEWEB)

    Geissler, A.; Bolender, T.; Hauser, G. [Kassel Univ. (Germany). Fachgebiet Bauphysik

    1997-05-01

    To determine the air tightness of the external envelope, blower door measurements are normally carried out. The thus determined integral figure for the complete structure is an insufficient basis for carrying out specific insulation procedures in existing buildings. Within the scope of the air tightness measurements with the blower door, additional measuring methods permit the determination of additional information on the leakage distribution and the leakage routes. The expanded measuring methods that are known from the bibliography `opening a door` and `adding a hole` as well as the new method of `adding a hole plus` are explained, compared by means of exemplary measurements, and are considered for their suitability during field trials. (orig.) [Deutsch] Zur Bestimmung der Luftdichtheit der Gebaeudehuelle werden im allgemeinen Blower Door-Messungen durchgefuehrt. Der hierbei bestimmte integrale Wert fuer das gesamte Gebaeude stellt fuer das Ergreifen von gezielten Abdichtungsmassnahmen im Gebaeudebestand eine zu geringe Basis dar. Weiterfuehrende Messmethoden erlauben, im Rahmen von Luftdichtheitsmessungen mit der Blower Door zusaetzliche Informationen ueber die Leckageverteilung und ueber Leckagewege zu bestimmen. Die aus der Literatur bekannten erweiterten Messmethoden `Opening A Door` und `Adding A Hole` sowie die neue Methode `Adding A Hole Plus` werden erlaeutert, anhand von exemplarischen Messungen verglichen und im Feldeinsatz auf ihre Anwendbarkeit hin betrachtet. (orig.)

  12. A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development.

    Science.gov (United States)

    Gao, Junling; Ceglia, Scott S; Jones, Michael D; Simeone, Jennifer; Antwerp, John Van; Zhang, Li-Kang; Ross, Charles W; Helmy, Roy

    2016-04-15

    A new 'compact mass detector' co-developed with an instrument manufacturer (Waters Corporation) as an interface for liquid chromatography (LC), specifically Ultra-high performance LC(®) (UPLC(®) or UHPLC) analysis was evaluated as a potential new Open Access (OA) LC-MS platform in the Drug Discovery and Early Development space. This new compact mass detector based platform was envisioned to provide increased reliability and speed while exhibiting significant cost, noise, and footprint reductions. The new detector was evaluated in batch mode (typically 1-3 samples per run) to monitor reactions and check purity, as well as in High Throughput Screening (HTS) mode to run 24, 48, and 96 well plates. The latter workflows focused on screening catalysis conditions, process optimization, and library work. The objective of this investigation was to assess the performance, reliability, and flexibility of the compact mass detector in the OA setting for a variety of applications. The compact mass detector results were compared to those obtained by current OA LC-MS systems, and the capabilities and benefits of the compact mass detector in the open access setting for chemists in the drug discovery and development space are demonstrated.

  13. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

    OpenAIRE

    Sean Ekins; Perryman, Alexander L.; Carolina Horta Andrade

    2016-01-01

    The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of...

  14. Maintaining the momentum of Open Search in Earth Science Data discovery

    Science.gov (United States)

    Newman, D. J.; Lynnes, C.

    2013-12-01

    Federated Search for Earth Observation data has been a hallmark of EOSDIS (Earth Observing System Data and Information System) for two decades. Originally, the EOSDIS Version 0 system provided both data-collection-level and granule/file-level search in the mid 1990s with EOSDIS-specific socket protocols and message formats. Since that time, the advent of several standards has helped to simplify EOSDIS federated search, beginning with HTTP as the transfer protocol. Most recently, OpenSearch (www.opensearch.org) was employed for the EOS Clearinghouse (ECHO), based on a set of conventions that had been developed within the Earth Science Information Partners (ESIP) Federation. The ECHO OpenSearch API has evolved to encompass the ESIP RFC and the Open Geospatial Consortium (OGC) Open Search standard. Uptake of the ECHO Open Search API has been significant and has made ECHO accessible to client developers that found the previous ECHO SOAP API and current REST API too complex. Client adoption of the OpenSearch API appears to be largely driven by the simplicity of the OpenSearch convention. This simplicity is thus important to retain as the standard and convention evolve. For example, ECHO metrics indicate that the vast majority of ECHO users favor the following search criteria when using the REST API, - Spatial - bounding box, polygon, line and point - Temporal - start and end time - Keywords - free text Fewer than 10% of searches use additional constraints, particularly those requiring a controlled vocabulary, such as instrument, sensor, etc. This suggests that ongoing standardization efforts around OpenSearch usage for Earth Observation data may be more productive if oriented toward improving support for the Spatial, Temporal and Keyword search aspects. Areas still requiring improvement include support of - Concrete requirements for keyword constraints - Phrasal search for keyword constraints - Temporal constraint relations - Terminological symmetry between search URLs

  15. Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries.

    Science.gov (United States)

    Abrahão, Jônatas S; Dornas, Fábio P; Silva, Lorena C F; Almeida, Gabriel M; Boratto, Paulo V M; Colson, Phillipe; La Scola, Bernard; Kroon, Erna G

    2014-06-30

    In 2003, Acanthamoeba polyphaga mimivirus (APMV) was first described and began to impact researchers around the world, due to its structural and genetic complexity. This virus founded the family Mimiviridae. In recent years, several new giant viruses have been isolated from different environments and specimens. Giant virus research is in its initial phase and information that may arise in the coming years may change current conceptions of life, diversity and evolution. Thus, this review aims to condense the studies conducted so far about the features and peculiarities of APMV, from its discovery to its clinical relevance.

  16. Leveraging Open Standard Interfaces in Providing Efficient Discovery, Retrieval, and Information of NASA-Sponsored Observations and Predictions

    Science.gov (United States)

    Cole, M.; Alameh, N.; Bambacus, M.

    2006-05-01

    The Applied Sciences Program at NASA focuses on extending the results of NASA's Earth-Sun system science research beyond the science and research communities to contribute to national priority applications with societal benefits. By employing a systems engineering approach, supporting interoperable data discovery and access, and developing partnerships with federal agencies and national organizations, the Applied Sciences Program facilitates the transition from research to operations in national applications. In particular, the Applied Sciences Program identifies twelve national applications, listed at http://science.hq.nasa.gov/earth-sun/applications/, which can be best served by the results of NASA aerospace research and development of science and technologies. The ability to use and integrate NASA data and science results into these national applications results in enhanced decision support and significant socio-economic benefits for each of the applications. This paper focuses on leveraging the power of interoperability and specifically open standard interfaces in providing efficient discovery, retrieval, and integration of NASA's science research results. Interoperability (the ability to access multiple, heterogeneous geoprocessing environments, either local or remote by means of open and standard software interfaces) can significantly increase the value of NASA-related data by increasing the opportunities to discover, access and integrate that data in the twelve identified national applications (particularly in non-traditional settings). Furthermore, access to data, observations, and analytical models from diverse sources can facilitate interdisciplinary and exploratory research and analysis. To streamline this process, the NASA GeoSciences Interoperability Office (GIO) is developing the NASA Earth-Sun System Gateway (ESG) to enable access to remote geospatial data, imagery, models, and visualizations through open, standard web protocols. The gateway (online

  17. Self-Discovery through Character Connections: Opening up to Gayness in "Angels in America"

    Science.gov (United States)

    Blazar, David

    2009-01-01

    In this article, the author describes how he uses performance pedagogy to open students' minds to sexuality and gender issues. The author uses Tony Kushner's "Angels in America: A Gay Fantasia on National Themes"--an epic play about the AIDS epidemic and its impact on the gay community in the 1980s. Through the possibilities of drama available in…

  18. Improving knowledge discovery from synthetic aperture radar images using the linked open data cloud and Sextant

    NARCIS (Netherlands)

    Nikolaou, C.; Kyzirakos, K.; Bereta, K.; Dogani, K.; Giannakopoulou, S.; Smeros, P.; Garbis, G.; Koubarakis, M.; Molina, D.E.; Dumitru, O.C.; Schwarz, G.; Datcu, M.; Soille, P.; Iapaolo, M.; Marchetti, P.G.; Datcu, M.; Colaiacomo, L.

    2014-01-01

    In the last few years, thanks to projects like TELEIOS, the linked open data cloud has been rapidly populated with geospatial data some of it describing Earth Observation products (e.g., CORINE Land Cover, Urban Atlas). The abundance of this data can prove very useful to the new missions (e.g., Sent

  19. Discovery of metabolically stabilized electronegative polyacridine-PEG peptide DNA open polyplexes.

    Science.gov (United States)

    Fernandez, Christian A; Baumhover, Nicholas J; Anderson, Kevin; Rice, Kevin G

    2010-04-21

    Cationic condensing peptides and polymers bind electrostatically to DNA to form cationic polyplexes. While many cationic polyplexes are able to achieve in vitro transfection mediated through electrostatic interactions, few have been able to mediate gene transfer in vivo. The present study describes the development and testing of polyacridine PEG-peptides that bind to plasmid DNA by intercalation resulting in electronegative open polyplex DNA. Polyacridine PEG-peptides were prepared by chemically conjugating 6-(9-acridinylamino) hexanoic acid onto side chains of Lys in PEG-Cys-Trp-(Lys)(3, 4, or 5). The resulting PEG-Cys-Trp-(Lys-(Acr))(3, 4, or 5) peptides bound tightly to DNA by polyintercalation, rather than electrostatic binding. Unlike polycationic polyplexes, polyacridine PEG-peptide polyplexes were anionic and open coiled, as revealed by zeta potential and atomic force microscopy. PEG-Cys-Trp-(Lys-(Acr))(5) showed the highest DNA binding affinity and the greatest ability to protect DNA from metabolism by DNase. Polyacridine PEG-peptide DNA open polyplexes were dosed intramuscularly and electroporated in mice to demonstrate their functional activity in gene transfer. These results establish polyacridine PEG-peptide DNA open polyplexes as a novel gene delivery method for in vivo use.

  20. VIVO Open Source Software: Connecting Facilities to Promote Discovery and Further Research.

    Science.gov (United States)

    Gross, M. B.; Rowan, L. R.; Mayernik, M. S.; Daniels, M. D.; Stott, D.; Allison, J.; Maull, K. E.; Krafft, D. B.; Khan, H.

    2016-12-01

    EarthCollab (http://earthcube.org/group/earthcollab), a National Science Foundation (NSF) EarthCube Building Block project, has adapted an open source semantic web application, VIVO, for use within the earth science domain. EarthCollab is a partnership between UNAVCO, an NSF facility supporting research through geodetic services, the Earth Observing Laboratory (EOL) at the National Center for Atmospheric Research (NCAR), and Cornell University, where VIVO was created to highlight the scholarly output of researchers at universities. Two public sites have been released: Connect UNAVCO (connect.unavco.org) and Arctic Data Connects (vivo.eol.ucar.edu). The core VIVO software and ontology have been extended to work better with concepts necessary for capturing work within UNAVCO's and EOL's province such as principal investigators for continuous GPS/GNSS stations at UNAVCO and keywords describing cruise datasets at EOL. The sites increase discoverability of large and diverse data archives by linking data with people, research, and field projects. Disambiguation is a major challenge when using VIVO and open data when "anyone can say anything about anything." Concepts and controlled vocabularies help to build consistent and easily searchable connections within VIVO. We use aspects of subject heading services such as FAST and LOC, as well as AGU and GSA fields of research and subject areas to reveal connections, especially with VIVO instances at other institutions. VIVO works effectively with persistent IDs and the projects strive to utilize publication and data DOIs, ORCIDs for people, and ISNI and GRID for organizations. ORCID, an open source project, is very useful for disambiguation and unlike other identifier systems for people developed by publishers, makes public data available via an API. VIVO utilizes Solr and Freemarker, which are open source search engine and templating technologies, respectively. Additionally, a handful of popular open source libraries and

  1. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

    Science.gov (United States)

    2016-01-01

    The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to participate, and patents were not sought. One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change. A second subseries displayed high potency, including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by the community; new findings may be cumulatively added to the present work. PMID:27800551

  2. Relativistic jets in narrow-line Seyfert 1 galaxies. New discoveries and open questions

    Directory of Open Access Journals (Sweden)

    D’Ammando F.

    2013-12-01

    Full Text Available Before the launch of the Fermi satellite only two classes of AGNs were known to produce relativistic jets and thus emit up to the γ-ray energy range: blazars and radio galaxies, both hosted in giant elliptical galaxies. The first four years of observations by the Large Area Telescope on board Fermi confirmed that these two are the most numerous classes of identified sources in the extragalactic γ-ray sky, but the discovery of γ-ray emission from 5 radio-loud narrow-line Seyfert 1 galaxies revealed the presence of a possible emerging third class of AGNs with relativistic jets. Considering that narrow-line Seyfert 1 galaxies seem to be typically hosted in spiral galaxy, this finding poses intriguing questions about the nature of these objects, the onset of production of relativistic jets, and the cosmological evolution of radio-loud AGN. Here, we discuss the radio-to-γ-rays properties of the γ-ray emitting narrow-line Seyfert 1 galaxies, also in comparison with the blazar scenario.

  3. Relativistic jets in narrow-line Seyfert 1 galaxies. New discoveries and open questions

    CERN Document Server

    D'Ammando, F; Finke, J; Larsson, J; Giroletti, M

    2013-01-01

    Before the launch of the Fermi satellite only two classes of AGNs were known to produce relativistic jets and thus emit up to the gamma-ray energy range: blazars and radio galaxies, both hosted in giant elliptical galaxies. The first four years of observations by the Large Area Telescope on board Fermi confirmed that these two are the most numerous classes of identified sources in the extragalactic gamma-ray sky, but the discovery of gamma-ray emission from 5 radio-loud narrow-line Seyfert 1 galaxies revealed the presence of a possible emerging third class of AGNs with relativistic jets. Considering that narrow-line Seyfert 1 galaxies seem to be typically hosted in spiral galaxy, this finding poses intriguing questions about the nature of these objects, the onset of production of relativistic jets, and the cosmological evolution of radio-loud AGN. Here, we discuss the radio-to-gamma-rays properties of the gamma-ray emitting narrow-line Seyfert 1 galaxies, also in comparison with the blazar scenario.

  4. Modified open-door laminoplasty for multiple-segment cervical spondylotic myelopathy%改良颈椎后路单开门椎管扩大成形术治疗多节段脊髓型颈椎病

    Institute of Scientific and Technical Information of China (English)

    孔凡磊; 聂志红; 刘中坡; 武玉江; 付秀信

    2013-01-01

    Objectives: To discuss the clinical effect of C3 laminectomy and C4-C7 open-door laminoplasty for cervical spondylotic myelopathy(CSM). Methods: From January 2009 to October 2011, 74 patients underwent extensive open-door laminoplasty, detailed as C3 laminectomy reserving attachment of musculus semi-spinalis cervicis and C4-C7 modified open-door laminoplasty. 57 patients got follow-up. Among them, there were 31 males and 26 females. The ages ranged from 50 to 71 years with a mean age of 63 years. The JOA scores were 4-11 points, with a mean of 8.5±2.0 before the operation. The range of motion was 23°-49° with a mean of 37.4°±10.3°. The cervical curvature index was 6.0%-22.0%, with a mean of (13.9±7.4)%. The preoperative and postoperative JOA scores were recorded. The JOA score and the incidence of axial symptom were reviewed. At six months after the operation, the change of ROM and cervical curvature index was noted. Results: The mean operative time was 70min ranging from 50 to 110min. The mean volume of blood loss was 230ml ranging from 150ml to 600ml. No complication such as spinal cord injury or cerebrospinal fluid leakage was noted. 41 patients had early postoperative neck pain, which resolved after corresponsive management. The rate of evident axial symptom was 15.8%. Two patients developed wound infection. Six patients were complicated with C5 nerve root palsy, which alleviated after symptomatic treatment. The patients with postoperative neurological deficit improved to different degrees. The postoperative JOA scores were 10-17 points, with a mean of 13.8±2.3 points, which showed significant difference (P<0.05). The JOA improvement rate was 29.0%-77.3%, with a mean of (57.0±19.7)%. Loss of cervical curvature index was (2.9±2.4)%. The range of motion was 18°-46° with a mean of 28.2°±10.8°, and the loss of ROM was 8.2°±5.1°. No door-re-close was noted during follow-up. Conclusions: C3 laminectomy reserving attachment of musculus semi

  5. Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma.

    Directory of Open Access Journals (Sweden)

    Megan Ulmer Carnes

    Full Text Available Glaucoma is a leading cause of blindness worldwide. Primary open-angle glaucoma (POAG is the most common subtype and is a complex trait with multigenic inheritance. Genome-wide association studies have previously identified a significant association between POAG and the SIX6 locus (rs10483727, odds ratio (OR = 1.32, p = 3.87×10(-11. SIX6 plays a role in ocular development and has been associated with the morphology of the optic nerve. We sequenced the SIX6 coding and regulatory regions in 262 POAG cases and 256 controls and identified six nonsynonymous coding variants, including five rare and one common variant, Asn141His (rs33912345, which was associated significantly with POAG (OR = 1.27, p = 4.2×10(-10 in the NEIGHBOR/GLAUGEN datasets. These variants were tested in an in vivo Danio rerio (zebrafish complementation assay to evaluate ocular metrics such as eye size and optic nerve structure. Five variants, found primarily in POAG cases, were hypomorphic or null, while the sixth variant, found only in controls, was benign. One variant in the SIX6 enhancer increased expression of SIX6 and disrupted its regulation. Finally, to our knowledge for the first time, we have identified a clinical feature in POAG patients that appears to be dependent upon SIX6 genotype: patients who are homozygous for the SIX6 risk allele (His141 have a statistically thinner retinal nerve fiber layer than patients homozygous for the SIX6 non-risk allele (Asn141. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells, thereby increasing the risk of glaucoma-associated vision loss.

  6. Landing Gear Door Liners for Airframe Noise Reduction

    Science.gov (United States)

    Jones, Michael G. (Inventor); Howerton, Brian M. (Inventor); Van De Ven, Thomas (Inventor)

    2014-01-01

    A landing gear door for retractable landing gear of aircraft includes an acoustic liner. The acoustic liner includes one or more internal cavities or chambers having one or more openings that inhibit the generation of sound at the surface and/or absorb sound generated during operation of the aircraft. The landing gear door may include a plurality of internal chambers having different geometries to thereby absorb broadband noise.

  7. Changes of sagittal balance of cervical spine after open-door expansive laminoplasty%颈后路单开门椎管扩大椎板成形术后颈椎矢状面平衡的变化

    Institute of Scientific and Technical Information of China (English)

    林圣荣; 周非非; 孙宇; 陈仲强; 张凤山; 潘胜发

    2014-01-01

    Objective To explore the changes of sagittal balance of cervical spine after open-door expansive laminoplasty.Methods The clinical and radiological data were analyzed retrospectively for 90 patients undergoing open-door expansive laminoplasty due to cervical spondylotic myelopathy.The Japanese Orthopedic Association (JOA) score and 3 cervical sagittal parameters including C2-C7 SVA,C0-2 Cobb angle and T1-Slope on lateral view radiographs were recorded before operation and at the final follow-up.Results The average follow-up period was 16.7 (3-40) months.The post-operative JOA score rose to 14.6 ±0.2 from pre-operative 12.2 ±0.3 with 43.5% ±4.2% recovery rate.The post-operative values of C2-C7 SVA,C0-2 Cobb angle and T1-Slope were significantly different from pre-operative ones (P =0.022,P <0.001,P =0.002).C2-C7 SVA increased to (23.0 ± 1.2) mm from pre-operative (20.7 ± 1.1) mm.C0-2 Cobb angle increased (23.1 ± 0.8) ° from pre-operative (19.9 ± 0.8) ° ; T1-Slope increased to (26.2 ± 0.7) ° from pre-operative (25.1 ± 0.7) °.The changes of C0-2 Cobb angle and T1-Slope were correlated with that of C2-C7 SVA respectively (Pearson =0.469,P < 0.001) (Pearson =0.303,P =0.004).Patients with higher preoperative T1-Slope had less JOA improvement(31.5% vs 53.7%,P =0.019)than those with lower preoperative T1-Slope after laminoplasty.Conclusion The sagittal balance of cervical spine significantly changes after open-door expansive laminoplasty with forward tilting of cervical vertebra.And compensation occurs by excessive high-strength contraction of posterior muscles to maintain lordosis in upper cervical spine.A higher pre-OP T1-Slope affects the outcomes of open-door expansive laminoplasty.%目的 探索颈后路椎管扩大椎板成形术后颈椎矢状位平衡变化.方法 2008年1月至2011年7月北京大学第三医院骨科对90例因脊髓型颈椎病接受C3-C7颈后路单开门椎管扩大椎板成形术患者的临床和影像学资料进

  8. Particulate matter (PM 2.5 levels in ETS emissions of a Marlboro Red cigarette in comparison to the 3R4F reference cigarette under open- and closed-door condition

    Directory of Open Access Journals (Sweden)

    Mueller Daniel

    2012-06-01

    Full Text Available Abstract Introduction Potential health damage by environmental emission of tobacco smoke (environmental tobacco smoke, ETS has been demonstrated convincingly in numerous studies. People, especially children, are still exposed to ETS in the small space of private cars. Although major amounts of toxic compounds from ETS are likely transported into the distal lung via particulate matter (PM, few studies have quantified the amount of PM in ETS. Study aim The aim of this study was to determine the ETS-dependent concentration of PM from both a 3R4F reference cigarette (RC as well as a Marlboro Red brand cigarette (MRC in a small enclosed space under different conditions of ventilation to model car exposure. Method In order to create ETS reproducibly, an emitter (ETSE was constructed and mounted on to an outdoor telephone booth with an inner volume of 1.75 m3. Cigarettes were smoked under open- and closed-door condition to imitate different ventilation scenarios. PM2.5 concentration was quantified by a laser aerosol spectrometer (Grimm; Model 1.109, and data were adjusted for baseline values. Simultaneously indoor and outdoor climate parameters were recorded. The time of smoking was divided into the ETS generation phase (subset “emission” and a declining phase of PM concentration (subset “elimination”; measurement was terminated after 10 min. For all three time periods the average concentration of PM2.5 (Cmean-PM2.5 and the area under the PM2.5 concentration curve (AUC-PM2.5 was calculated. The maximum concentration (Cmax-PM2.5 was taken from the total interval. Results For both cigarette types open-door ventilation reduced the AUC-PM2.5 (RC: from 59 400 ± 14 600 to 5 550 ± 3 900 μg*sec/m3; MRC: from 86 500 ± 32 000 to 7 300 ± 2 400 μg*sec/m3; p mean-PM2.5 (RC: from 600 ± 150 to 56 ± 40 μg/m3, MRC from 870 ± 320 to 75 ± 25 μg/m3; p max-PM2.5 was reduced by about 80% (RC: from 1 050 ± 230 to

  9. Air curtain development: an energy harvesting solution for hinged doors

    Science.gov (United States)

    Dayal, Vineed; Lee, Soobum

    2017-04-01

    The paper proposes a fully mechanical air curtain system that will be powered solely by harvested energy from common hinged doors. The average person uses this type of door several times a day with an almost unconscious amount of applied force and effort. This leads to a high potential of energy to be harvested in doorways that see high traffic and frequent operation7 . Frequently opened door entry ways have always been regarded as a major element that causes significant energy loss and contaminated air conditions in buildings6 . Private companies, particularly those with warehouses, have introduced commercial electrical air curtains to block the open entrances from invading cold air11. This project intends to introduce an original design of air curtain which operates fans only when the door opens and closes, by directly converting door motion to fan rotation without any electronic motor or power cable. The air stream created by this device will prevent the transfer of outside air and contaminants. Research will be conducted to determine the most efficient method of harvesting energy from door use, and the prototyping process will be conducted to meet the required performance of current air curtain models.

  10. Opening the Door on Triangular Numbers

    Science.gov (United States)

    McMartin, Kimberley; McMaster, Heather

    2016-01-01

    As an alternative to looking solely at linear functions, a three-lesson learning progression developed for Year 6 students that incorporates triangular numbers to develop children's algebraic thinking is described and evaluated.

  11. Facility Accessibility: Opening the Doors to All

    Science.gov (United States)

    Petersen, Jeffrey C.; Piletic, Cindy K.

    2006-01-01

    A facility developed for fitness, physical activity, recreation, or sport is a vital community resource that contributes to the overall health and wellness of that community's citizens. In order to maximize the benefits derived from these facilities, it is imperative that they be accessible to as wide a range of people as possible. The Americans…

  12. Opening doors to knowledge in Bhutan.

    Science.gov (United States)

    1994-01-01

    School girls, teachers, and health school students were surveyed, using 3 different questionnaires, in January 1993. Catherine Payne, former research associate of the Family Planning Council of Southeastern Pennsylvania, visited Bhutan from August 18 through September 4, 1993, to assist with the interpretation of results and to interview teachers in schools where the new curriculum would be introduced and officials who were writing it. Results were released in October 1993. 160 young women (10-20 years of age) from 5 schools were surveyed and another 60 were interviewed by Payne. 25% of the surveyed girls understood the connection between menstruation and reproduction. Of those who had heard of menstruation, 60% had heard about it from their friends; 30%, from siblings; 27%, from mothers; and 10%, from schools. Teachers in the survey were supportive of the study and recognized the importance of reproductive health education. Also, officials of the education and health ministries, epidemiologists, experts in information, education, and communication (IEC), and district health officers attended a 2-day workshop directed at local data collection and analysis of this type. Although teenage pregnancy and sexually transmitted diseases (STDs) are increasing in Bhutan, family planning services are not reaching youth, particularly those who do not attend school or do not have children. Hospitals provide contraceptives mainly to those over 21, and outreach clinics are not catering to the family planning needs of minors. One of the recommendations of this survey/workshop was to provide correct information on reproductive health to youth.

  13. Opening the door for foreign banks

    Institute of Scientific and Technical Information of China (English)

    WANGPEI

    2004-01-01

    Will central government's tightening policy bring further opportunities to foreign banks?And with less capital available for lending,how much ground will domestic banks lose to their foreign-invested competitors?

  14. Opening the Mexican Door: Continental Defense Cooperation

    Science.gov (United States)

    2005-09-01

    safety agencies. 18 For more information on the U.S. - Mexico Border Partnership Action Plan see http://www.whitehouse.gov/infocus/usmxborder...Frente al Libre Comercio (RMALC) La Neta – Proyecto Emisiones: Espacio Virtual. Hazardous Waste Management in the United States – Mexico Border States...Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction

  15. Open the Door for Reading (Motivational Activities).

    Science.gov (United States)

    Voorhees, Roxy

    Designed to help elementary teachers motivate students to read, this illustrated booklet presents a store of classroom ideas that promote and enrich reading. Materials presented include (1) instructions for making a "bookworm" bookmark for each student; (2) various animated bulletin board games intended to accompany the reading process and to help…

  16. Knocking on a wide open door

    DEFF Research Database (Denmark)

    Kragelund, Peter

    2009-01-01

    Chinese policies to gain access to resources and markets, but also the consequence of liberal African investment policies imposed by Western donors in the past. This article uses Zambia as a case study to challenge the often one-sided view of the local consequences of China's engagement with Africa......The current strong foothold of Chinese enterprises on the African continent concerns many western observers. They fear that the West will lose leverage in Africa and simultaneously postpone development. Paradoxically, the advance of Chinese enterprises in Africa is not only the result of deliberate......, and it shows that we need to consider the type of policies that guide investment flows in order to increase the local benefits of China's growing presence in the continent....

  17. Communication Opens the Door of Reading Improvement

    Science.gov (United States)

    Corlett, Donna

    1973-01-01

    Elaborates some of the communication techniques used in a reading laboratory for minority college students who have educational lags in their reading skills. The combination of improved classroom communication and effective reading practice have resulted in special success in reading achievement at the University of Portland, Portland, Oregon.…

  18. Time to Open the BRIC Door

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    MUCH has been said about South Africa joining the BRIC.Detractors say that the country is punching way above its weight. One of the biggest critics of the inclusion has been Jim O’Neill,Chairperson of Goldman Sachs Asset Management,who originally coined the term BRIC in 2001. O’Neill is on record as saying that he believes South Africa was invited for political reasons and not economical ones.He says South Africa’s working population is too small,and therefore had plumped for Nigeria to be a better choice to join the BRIC.South Africa’s total population is 50 million with Nigeria triple that at 150 million.

  19. The Globe reopens its doors

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    After a year of work, the newly renovated Globe of Science and Innovation will open its doors again at 10 a.m. on Tuesday, 19 April. The “Universe of Particles” exhibition has been updated and will be open to the public, free of charge, from 10 a.m. to 5 p.m., Monday to Saturday (except during official CERN closures). The Globe’s programme of lectures and events for the general public will restart at the end of April. What’s on at the Globe in April and May: - 28 April at 6.30 p.m.: Theatre – “Curie_Meitner_Lamarr_indivisible”, a play that pays tribute to the lives of three exceptional women in the field of science and technology (in English). Reservations: http://indico.cern.ch/e/cmli - 10 May at 8.30 p.m.: Lecture – “Le modèle du CERN et les grands défis mondiaux” (“The CERN model and the key global challenges”) by Michel Spiro (in French with simultaneous ...

  20. A Door-to-Door Combined Transport Planner

    DEFF Research Database (Denmark)

    Aastrup, Jesper; Jespersen, Per Homann; Pedersen, Michael B.

    2004-01-01

    Establishing a web-based portal functioning as a one-stop-shop for transport buyers is a radical idea of a consumer oriented intermodal freight system. This utopian vision will be materialized in a system description and a prototype of a Door-to-Door Combined Trans-port Planner (COTRAP), developed...

  1. Opening Data in the Long Tail for Community Discovery, Curation and Action Using Active and Social Curation

    Science.gov (United States)

    Hedstrom, M. L.; Kumar, P.; Myers, J.; Plale, B. A.

    2012-12-01

    In data science, the most common sequence of steps for data curation are to 1) curate data, 2) enable data discovery, and 3) provide for data reuse. The Sustainable Environments - Actionable Data (SEAD) project, funded through NSF's DataNet program, is creating an environment for sustainability scientists to discover data first, reuse data next, and curate data though an on-going process that we call Active and Social Curation. For active curation we are developing tools and services that support data discovery, data management, and data enhancement for the community while the data is still being used actively for research. We are creating an Active Content Repository, using drop box, semantic web technologies, and a Flickr-like interface for researchers to "drop" data into a repository where it will be replicated and minimally discoverable. For social curation, we are deploying a social networking tool, VIVO, which will allow researchers to discover data-publications-people (e.g. expertise) through a route that can start at any of those entry points. The other dimension of social curation is developing mechanisms to open data for community input, for example, using ranking and commenting mechanisms for data sets and a community-sourcing capability to add tags, clean up and validate data sets. SEAD's strategies and services are aimed at the sustainability science community, which faces numerous challenges including discovery of useful data, cleaning noisy observational data, synthesizing data of different types, defining appropriate models, managing and preserving their research data, and conveying holistic results to colleagues, students, decision makers, and the public. Sustainability researchers make significant use of centrally managed data from satellites and national sensor networks, national scientific and statistical agencies, and data archives. At the same time, locally collected data and custom derived data products that combine observations and

  2. Design and Development of Sound Control Door Lock System

    Directory of Open Access Journals (Sweden)

    Elechi Promise

    2015-09-01

    Full Text Available Security is very important, especially the security of lives and properties. This work involves the use of sound in controlling the opening and closing of doors using electromechanical application. In this work, sound is used to activate the mechanisms which opens and closes the door without any external effort. The system is made up of two main features, the Security Access system and Control Mechanism. The security access system was designed using circuit wizard software and then constructed on a veroboard and other materials while the control mechanism was constructed using a simple DC motor for the opening and closing of the door. In its operation, a specific sound pattern in form of a positive voltage is sent to pin 14 of IC1, pin 14 of IC1 is connected to a transistor(Q2 which causes the 555timer to oscillate sending pulses to pin 14 of IC2, during this, the output of IC2 then operates in a sequential mode. The code switch then sets the number of beat that will set IC3 into the desire sequential output set by the operator. The output signal energizes the relay which controls the DC motor to open the door and closes after a preset time.The testing showed quick and fast response in operation of the door lock system.

  3. Comparison of two kinds of open-door cervical expansive laminoplasty for multilevel cervical degenerative diseases%两种颈椎椎管扩大成形术治疗多节段颈椎退行性疾病的疗效比较

    Institute of Scientific and Technical Information of China (English)

    陈永和; 唐劲忠; 黄胜; 刘少喻; 彭新生; 邹学农; 万勇

    2015-01-01

    Objective To investigate the clinical effects and surgical complications of unilateral and bilateral open-door cervical expansive laminoplasty for multilevel cervical degenerative diseases. Methods A retrospective study was carried on 73 patients with multilevel cervical degenerative disease treated by cervical expansive laminoplasty from January 2008 to January 2013. According to different surgical procedures, they were divided into 2 groups, unilateral open-door group (32 patients) and bilateral open-door group (41 patients). The operation time, intraoperative estimate blood loss, Japanese Orthopaedic Association (JOA) scoring improvement rate and postoperative complications were compared between two groups. Results All patients were followed up with an average period of 34.8 months (range, 24 to 52 months), and three patients were lost to follow up after two years later. Operation time and intraoperative estimate blood loss in unilateral open-door group were less than those in bilateral open-door group (P 0.05). In unilateral open-door group, incidence of C5 nerve root palsy, cerebrospinal fluid leakage or surgical site infection (6%, 3%, 3%) was lower than that in bilateral open-door group (7%, 10%, 5%) respectively, but the differences between two groups had no statistical significance (P >0.05); Incidence of axial symptoms in unilateral open-door group (31%) was higher compared with that in bilateral open-door group (12%), there was statistical difference between two groups (P <0.05). Conclusions Both unilateral and bilateral open-door cervical expansive laminoplasty are effective for the treatment of multilevel cervical degenerative diseases, in which the former has shorter operation time and less intraoperative estimate blood loss, while the latter has lower incidence of axial symptoms.%目的:探讨单开门、双开门两种椎管扩大成形术治疗多节段颈椎退行性疾病的临床疗效及并发症发生情况。方法回顾性分析2008年1

  4. Effect of lamina open angles in expansion of unilateral open-door laminoplasty on the clinical results in treating cervical myelopathy%颈椎单开门椎管扩大成形术椎板开门角度对脊髓型颈椎病疗效的影响

    Institute of Scientific and Technical Information of China (English)

    孙天威; 张杭; 卢守亮; 李辉南; 于斌; 张学利

    2012-01-01

    Objective:To evaluate and compare the relation between the efficacy and clinical results of expansion of open-door laminoplasty with different angles in lamina open- door.Method: 198 cases were select from July 2006 to January 2009 who underwent posterior cervical unilateral open-doorJaminoplasty and received treatment for more than 24 months follow-up of patients with cervical myelopathy.There were 115 male cases and 83 female case with the mean age of 49±5 years (range,29-72 years).There were 39 double-segment cases,including 11 C3-C5 cases and 28 C4-C6 cases;97 three-segment (C4-C7) cases and 62 four segment (C3-C7) cases.All of these cases iiad cervical spine anterior-posterior and lateral, oblique and double-bit excessive flexion and extension cervical spine X-ray,CT and MRI.Preoperative JOA scores were 4 to 9,an average of 6.3±2.9.By CT scan after 1 week in accordance with the measurement on the angle of the lamina to 30° for the open boundaries,the cases were divided into two groups,to compare operation time, blood loss,postoperative complications,C2-C7 Cobb angle,index of cervical lordosis,cervical movement and tovalues after the shift,and evaluate the neurological function at final follow-up and calculate improvement rate of nerve function.Result:Group A:a total of 76 cases had an opening angle change>30°.Group B: a total 122 cases had an opening angle change 15°-30°.In preoperative JOA scores,C2-C7 Cobb angle,index of cervical lordosis,cervical movement between the two groups showed no statistically significant difference (P>0.05).The surgical time and blood loss in group A were 110±13min and 250±80ml,and in group B respectively 120± 30min and 230±100ml,the difference was not statistically significant (P>0.05).In group A,51 patients after surgery(67.1%) had axial symptoms,8 patients(10.4%) with C5 nerve root palsy, 1 patient(1.32%) with mild cervical kyphosis.In group B,37 cases (10.5%) had axial symptoms,3 patients (2.4%) with C5 nerve root

  5. Genetics Home Reference: DOORS syndrome

    Science.gov (United States)

    ... do not have all of these features. Most people with DOORS syndrome have profound hearing loss caused by changes in the inner ears (sensorineural deafness). Developmental delay and intellectual disability are also often severe in this disorder. The ...

  6. Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling.

    Directory of Open Access Journals (Sweden)

    Kristofer Davie

    2015-02-01

    Full Text Available Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs. When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically detectable as nucleosome-depleted regions or accessible/open chromatin. Here we ask whether open chromatin profiling can be used to identify the entire repertoire of active promoters and enhancers underlying tissue-specific gene expression during normal development and oncogenesis in vivo. To this end, we first compare two different approaches to detect open chromatin in vivo using the Drosophila eye primordium as a model system: FAIRE-seq, based on physical separation of open versus closed chromatin; and ATAC-seq, based on preferential integration of a transposon into open chromatin. We find that both methods reproducibly capture the tissue-specific chromatin activity of regulatory regions, including promoters, enhancers, and insulators. Using both techniques, we screened for regulatory regions that become ectopically active during Ras-dependent oncogenesis, and identified 3778 regions that become (over-activated during tumor development. Next, we applied motif discovery to search for candidate transcription factors that could bind these regions and identified AP-1 and Stat92E as key regulators. We validated the importance of Stat92E in the development of the tumors by introducing a loss of function Stat92E mutant, which was sufficient to rescue the tumor phenotype. Additionally we tested if the predicted Stat92E responsive regulatory regions are genuine, using ectopic induction of JAK/STAT signaling in developing eye discs, and observed that similar chromatin changes indeed occurred. Finally, we determine that these are functionally significant regulatory changes, as nearby target genes are up- or down-regulated. In conclusion, we show that FAIRE-seq and ATAC-seq based open chromatin profiling

  7. The insulin secretory action of novel polycyclic guanidines: discovery through open innovation phenotypic screening, and exploration of structure-activity relationships.

    Science.gov (United States)

    Shaghafi, Michael B; Barrett, David G; Willard, Francis S; Overman, Larry E

    2014-02-15

    We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, 1-3, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of 9h, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. A Door-to-Door Combined Transport Planner

    DEFF Research Database (Denmark)

    Aastrup, Jesper; Jespersen, Per Homann; Pedersen, Michael B.

    2004-01-01

    Establishing a web-based portal functioning as a one-stop-shop for transport buyers is a radical idea of a consumer oriented intermodal freight system. This utopian vision will be materialized in a system description and a prototype of a Door-to-Door Combined Trans-port Planner (COTRAP), develope......- and inter-organizational barriers to the establishment of a competitive and effective combined transport system with rail freight operators as the intermodal integrator. In this paper we describes the ideas and methodology behind the project, as well as some preliminary results....

  9. The doors have been removed… for YOUR safety

    DEFF Research Database (Denmark)

    Abildgaard, Mette Simonsen

    A sociomaterial case study of how bombs (and their users), doors and politics instigated the destabilization and dismantling of the public telephone booth in Denmark, and the subsequent re-assembling process, through design contests and political struggle, to establish a new appropriate design...... Paper Long Abstract: This sociomaterial case study deals with the destabilization and dismantling of the public telephone booth in Denmark, which began in 1977-1978 when an unforeseen use - a series of bomb attacks - struck the booths in Copenhagen. As a safety measure, police removed the doors...... on the classic box-shaped telephone booths, which had been a part of Danish communication infrastructure since 1932. But the doors were never reinstalled after the capture of the user, who became known as The Telephone Bomber, and a competition for a new open design was commissioned in 1980. The winning design...

  10. 24 CFR 3280.113 - Glass and glazed openings.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Glass and glazed openings. 3280.113... Glass and glazed openings. (a) Windows and sliding glass doors. All windows and sliding glass doors shall meet the requirements of § 3280.403 the “Standard for Windows and Sliding Glass Doors Used...

  11. The Diffuse Light of the Universe - On the Microwave Background Before and After Its Discovery: Open Questions

    Science.gov (United States)

    Bonnet-Bidaud, Jean-Marc

    2016-12-01

    In 1965, the discovery of a new type of uniform radiation, located between radiowaves and infrared light, was accidental. Known today as Cosmic Microwave background (CMB), this diffuse radiation is commonly interpreted as a fossil light released in an early hot and dense universe and constitutes today the main 'pilar' of the big bang cosmology. Considerable efforts have been devoted to derive fundamental cosmological parameters from the characteristics of this radiation that led to a surprising universe that is shaped by at least three major unknown components: inflation, dark matter and dark energy. This is an important weakness of the present consensus cosmological model that justifies raising several questions on the CMB interpretation. Can we consider its cosmological nature as undisputable? Do other possible interpretations exist in the context of other cosmological theories or simply as a result of other physical mechanisms that could account for it? In an effort to questioning the validity of scientific hypotheses and the under-determination of theories compared to observations, we examine here the difficulties that still exist on the interpretation of this diffuse radiation and explore other proposed tracks to explain its origin. We discuss previous historical concepts of diffuse radiation before and after the CMB discovery and underline the limit of our present understanding.

  12. Ontkenning vaderschap door bijzondere curator namens minderjarige

    NARCIS (Netherlands)

    A.J.M. Nuytinck (André)

    2004-01-01

    textabstractOntkenning vaderschap door minderjarig kind, vertegenwoordigd door een daartoe benoemde bijzondere curator; niet vereist dat kind in staat is tot redelijke waardering belangen; belang van zeer jeugdig kind kan anders meebrengen

  13. Ontkenning vaderschap door bijzondere curator namens minderjarige

    NARCIS (Netherlands)

    A.J.M. Nuytinck (André)

    2004-01-01

    textabstractOntkenning vaderschap door minderjarig kind, vertegenwoordigd door een daartoe benoemde bijzondere curator; niet vereist dat kind in staat is tot redelijke waardering belangen; belang van zeer jeugdig kind kan anders meebrengen

  14. Smediger kaas door juiste voer

    NARCIS (Netherlands)

    Hettinga, K.A.; Dijkstra, J.

    2014-01-01

    Veel kaasmakers willen smedige (zachte, smeuïge) kaas maken, want de gemiddelde consument vindt die kaas het lekkerst. Kasper Hettinga en Jan Dijkstra van Wageningen Universiteit vertellen hoe de smedigheid van kaas kan worden beïnvloed door de samenstelling van het veevoer.

  15. Koperemissies door drinkwaterleidingen (herziene editie)

    NARCIS (Netherlands)

    Verweij W; Mons MN; Aalbers JEM; Cruchten RGH van; LWD

    1996-01-01

    Ge-inventariseerd werd wat er bekend is over de fluxen van koper door (corrosie van) waterleidingen naar rioolwaterzuiveringsinstallaties (rwzi's), rwzi-slib en het oppervlaktewater. Gebleken is dat in 1993 (landelijk gemiddeld) 57% van de koperbelasting van rwzi's afkomstig is van cor

  16. A Door-to-Door Combined Transport Planner

    DEFF Research Database (Denmark)

    Aastrup, Jesper; Jespersen, Per Homann; Pedersen, Michael B.

    2004-01-01

    - and inter-organizational barriers to the establishment of a competitive and effective combined transport system with rail freight operators as the intermodal integrator. In this paper we describes the ideas and methodology behind the project, as well as some preliminary results.......Establishing a web-based portal functioning as a one-stop-shop for transport buyers is a radical idea of a consumer oriented intermodal freight system. This utopian vision will be materialized in a system description and a prototype of a Door-to-Door Combined Trans-port Planner (COTRAP), developed...... to fulfill the requirements of potential customers and in interaction with customers, shippers, rail and road freight operators, rail infrastructure owners and other actors in the intermodal freight system. Conversely, successive versions of the COTRAP will be used as an instrument to identify intra...

  17. Discovery of 13 New Variable Stars in the Field of the Open Cluster NGC 2168 (M35)

    Institute of Scientific and Technical Information of China (English)

    Juei-Hwa Hu; Wing-Huen Ip; Xiao-Bin Zhang; Zhao-Ji Jiang; Jun Ma; Xu Zhou

    2005-01-01

    A wide-field time-series CCD photometric survey of variable stars in the field of the open cluster NGC 2168 was carried out using the BATC Schmidt telescope. In total 13 new variable stars are discovered with three W UMa systems,one EA type and two EB type eclipsing binaries (one of them could be a W UMa system), and seven pulsating stars including three candidates of δ Scuti stars.

  18. Locked doors in acute inpatient psychiatry: a literature review.

    Science.gov (United States)

    van der Merwe, M; Bowers, L; Jones, J; Simpson, A; Haglund, K

    2009-04-01

    Many acute inpatient psychiatric wards in the UK are permanently locked, although this is contrary to the current Mental Health Act Code of Practice. To conduct a literature review of empirical articles concerning locked doors in acute psychiatric inpatient wards, an extensive literature search was performed in SAGE Journals Online, EBM Reviews, British Nursing Index, CINAHL, EMBASE Psychiatry, International Bibliography of the Social Sciences, Ovid MEDLINE, PsycINFO and Google, using the search terms 'open$', 'close$', '$lock$', 'door', 'ward', 'hospital', 'psychiatr', 'mental health', 'inpatient' and 'asylum'. A total of 11 empirical papers were included in the review. Both staff and patients reported advantages (e.g. preventing illegal substances from entering the ward and preventing patients from absconding and harming themselves or others) and disadvantages (e.g. making patients feel depressed, confined and creating extra work for staff) regarding locked doors. Locked wards were associated with increased patient aggression, poorer satisfaction with treatment and more severe symptoms. The limited literature available showed the urgent need for research to determine the real effects of locked doors in inpatient psychiatry.

  19. The clinical application of unilateral open-door cervical expansive laminoplasty plus centerpiece titanium plate fixation for multilevel cervical spondylotic myelopathy%单开门椎管扩大成形Centerpiece钛板固定术治疗多节段脊髓型颈椎病的临床应用

    Institute of Scientific and Technical Information of China (English)

    曾云; 熊敏; 余化龙; 何宁; 王志勇; 刘志刚; 韩珩; 陈森; 郭乐运

    2012-01-01

    Objective To evaluate the efficacy of unilateral open -door cervical expansive laminoplasty plus centerpiece titanium plate fixation for multilevel cervical spondylotic myelopathy. Methods 39 patients with multilevel cervical spondylotic myelopathy were randomly divided into "centerpiece titanium plate" group and "tradition" group. Before and after operation, the JOA score were performed. The improving rate of nerve function,the rate of spinal canal expansion and the rates of complication were compared after operation. Results Before operation,both of the two groups were the same in age and JOA score (P>0.05). Two groups of operative time were respec-tively( 109±25) min and (lll±23) min,there were no significant differences between them(P>0.05). The rate of spinal canal expansion of "centerpiece titanium plate" group (61 %±21%)was obviously higher than"tradition"group(40%±17%)(P0.05),but"centerpiece titanium plate" group had a significant increase at 12 months after operation (P<0.05). CT scan at 3-6 months after operation displayed that door spindle already reach osseous fusion. There were no occurrence of "re-close of door" in two groups. Conclusion The rate9 of complication of "centerpiece titanium plate" group were lower than "tradition" group (P<0.05). Conclusion Unilateral open-door cervical expansive laminoplasty plus centerpiece titanium plate fixation is a new operation which is safe,simple,effective with few complication.%目的 评价单开门颈椎管扩大成形Centerpiece钛板固定术治疗多节段脊髓型颈椎病的临床应用价值.方法 39例多节段脊髓型颈椎病患者随机分为Centerpiece钛板组(18例)及传统组(21例),治疗前后行JOA评分,比较治疗后神经功能改善率、椎管扩大率、并发症发生率.结果 前两组年龄、JOA评分均无显著性差异;两组手术时间分别为(109±25) min和(111±23) min,无显著性差异( P>0.05);Centerpiece钛板组椎管扩大率(61%±21

  20. Biomechanics of expansive unilateral open-door laminoplasty of the cervical spine with OsteoMed M3 plate and screws%颈椎单开门OsteoMed M3钉板内固定椎管扩大成形术的生物力学研究

    Institute of Scientific and Technical Information of China (English)

    胡孔和; 吴强; 靳安民; 段扬; 席新华; 赵卫东

    2013-01-01

    目的 观察在单开门术中应用OsteoMed M3钉板内固定重建颈椎稳定性的效果.方法 6具新鲜颈椎标本,对每一标本先后行完整颈椎组、后路单开门OsteoMed M3钉板内固定组、后路椎板切除组、后路椎板切除加侧块钉棒内固定组的三维运动范围测试.结果 行后路钢板内固定组,在前屈(22.65±2.39)、后伸(15.63±1.56)、左侧弯(19.83±3.16)、右侧弯(16.90±2.13)及右旋(19.45±3.00)状态下运动范围与椎板切除组及侧块钉棒组之间的差异有统计学意义(P<0.05),与正常组的运动范围接近,差异无统计学意义(P>0.05);在左旋(20.67±2.89)状态下运动范围与其他各组之间的差异有统计学意义(P<0.05).椎板切除及侧块钉棒组与其他各组之间的差异有统计学意义(JP<0.05).结论 在单开门术中应用OsteoMed M3钉板内固定具有良好的生物力学性能,可重建颈椎稳定性.%Objective To investigate the stability of cervical vertebrae of the method for that OsteoMed M3 titanium plate and screws were used to secure the posterior elements in the open position after expansive unilateral open-door laminoplasty.Methods Six human cadaveric specimens were harvested freshly,and the range of motion of different groups was measured by a three-dimensional spinal stability test,including intact cervical specimens group,laminoplasty with plate group,laminectomy group,and laminectomy and fusion group.Results After expansive unilateral open-door laminoplasty,the plate group exhibited a more significant difference in angular motion than in laminectomy group,and laminectomy and fusion group in ROM of flexion (22.65 ± 2.39),extension (15.63 ± 1.56),left lateral bending (19.83 ±3.16),right lateral bending (16.90 ± 2.13) and right axial rotation (19.45 ± 3.00) (P < 0.05),and it was not significantly different from intact cervical specimens group (P > 0.05).The plate group exhibited a more significant difference in angular

  1. 两种颈后路单开门手术方法对颈椎曲度指数及活动度的影响%Clinical effect of two posterior single open-door laminoplasty on cervical curvature index and ranges of neck motion

    Institute of Scientific and Technical Information of China (English)

    孔凡磊; 申勇; 聂志红; 刘中坡; 纪江峰; 侯市宾

    2012-01-01

    [ Objective] To discuss clinical effect of two posterior single open - door laminoplasty on cervical curvature index and movement of the cervical spine. [Methods] Since June 2008 to September 2011, 41 patients underwent extensive open - door laminoplasty, as reserved insertion of musculus semispinalis cervicis with C3 laminectomy and C4_7 modified open - door laminoplasty using "anchoring metlaod" ( Group A) , 37 patients underwent conventional C3_7 open - door laminoplasty (Group B) . Preoperative and postoperative improvement rate of Japanese Orthopedic Association ( JO A) scores, ranges of neck motion, cervical curvature indices were recorded and compared. [ Results] The average of JOA improvement rate were (57. 5 ± 19.4)% for group A , and (56. 3 ± 19. 8)% for group B. There was no significant difference in JOA improvement rate between two groups. Loss of cervical curvature indices were (2. 86 ± 2.44)% in group A and (5. 31 ±2. 12)% in group B, and the difference was statistically significant (P < 0.01) . Loss of ranges of neck motion were (8. 27 ± 5. 03 ) ° in group A and (11. 06 ± 6. 97 ) ° in group B, significant difference was also seen (P < 0. 01) . [ Conclusion ] Compared with the conventional operation, C3 laminectomy and C4_7 modified open-door laminoplasty using "anchoring method" is effective in preventing the loss of cervical curvature index and movement of the cervical spine, with adequate decompression of the spinal cord.%[目的]探讨两种颈后路单开门手术方法对术后患者神经功能改善率、颈椎曲度指数、颈椎活动度的影响及其临床意义.[方法]自2008年6月~2011年9月,78例脊髓型颈椎病患者接受颈后路单开门椎管扩大成形术.A组41例患者行改良术式,即保留颈半棘肌肌止,切除C3椎板,C4-7“锚定法”单开门椎管扩大成形术.B组37例患者行传统C3-7单开门椎管成形术.计算两组患者神经功能改善率及术前术后颈椎曲度指数、颈椎活

  2. 后路单开门颈椎管扩大成形术联合微型钛板固定治疗颈椎后纵韧带骨化症16例%Use of titanium miniplate in cervical expansive open-door laminoplasty for the treatment of Cervical ossification of the posterior longitudinal ligament

    Institute of Scientific and Technical Information of China (English)

    汤志兵; 杨惠林; 王根林

    2011-01-01

    目的 探讨颈椎后路微型钛板内固定单开门椎管扩大成形术治疗颈椎后纵韧带骨化症(OPLL)的近期随访疗效.方法 选择2009年06月~2011年02月我院行后路单开门椎管扩大椎板成形术并获得完整随访资料的颈椎后纵韧带骨化症患者16例,手术开门减压节段均为C3~C7,"开门"侧均使用微型钛板内固定.采用JOA评分评价患者术前、术后神经功能,并计算改善率;对患者术前术后X线、CT及MRI影像学资料进行比较,分析颈椎曲度、椎管矢状径变化及脊髓压迫改善程度,并统计手术并发症.结果 所有患者随访6~26个月,平均16.4个月,JOA评分从术前平均8.4±1.1分提高至术后平均13.1±1.5分,平均改善率(52.81±16.4)%,差异有统计学意义(P<0.05),术后颈椎曲度为18.2±5.1°,与术前17.4±4.2°比较无统计学差异;术前椎管矢状径平均为9.2±1.3mm,术后平均为17.4±1.8mm (P<0.05),末次随访仍能维持;16例患者术后脊髓压迫较术前均明显改善.手术并发脑脊液漏1例,C5,神经根麻痹1例,轴性症状2例.结论 颈椎后路微型钛板内固定单开门椎管扩大成形术是治疗颈椎后纵韧带骨化症的一种安全有效的方法.%Objective Exploration of the efficacy of Use of titanium miniplate in cervical expansive open-door laminopla-sty( open-door ELAP )for the treatment of Cervical ossification of the posterior longitudinal ligament( OPLL I Methods From Jun 2009 to Feb 2011, a total of 16 cases with Cervical ossification of the posterior longitudinal ligament( OPLL ) underwent open-door ELAP and were followed up in our hospital. All patients had decompression range from C3 to C7, "open-door"side were fixed using titanium miniplate.The preoperative and postoperative neurological status was evaluated by JOA scoring system and the improvement rate was also calculated; The preoperative and postoperative imaging examination data including X-rays, CT and MR1 were also compared

  3. Holiday Door Decorating Contest Brings Cheer | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer Other than the time of year, what do the following have in common: the leg lamp from the movie “A Christmas Story,” a compilation of silly holiday jokes, a gingerbread house, and Santa on a motorcycle? All four were among the individual door winners for the Holiday Door Decorating Contest, held at NCI at Frederick in December. Employees dressed up their office doors, hallways, and even stairwells to participate. Entries for the contest included individual office doors as well as groups. Some employees even “decked the halls” of whole office buildings to participate.

  4. Literature Survey on Door Lock Security Systems

    National Research Council Canada - National Science Library

    Pradnya R Nehete; J P Chaudhari; S R Pachpande; K P Rane

    2016-01-01

    .... Due to the advancement in recent techniques, some door lock security systems are based on microcontroller, GSM, GPS, many sensors, software like MATLAB, PROTEUS, biometrics like face recognition...

  5. Extensivering van de begeleiding door het inzetten van peer- en self-assessment in IMTO

    NARCIS (Netherlands)

    Joosten-ten Brinke, Desirée

    2011-01-01

    Joosten-ten Brinke, D. (2011). Extensivering van de begeleiding door het inzetten van peer- en self-Assessment in IMTO. In E. Bakker, W. Giesbertz, J. von Grumbkow, & T. Houtmans (Red.), Ontwikkeling van de onderzoekscompetentie aan de Open Universiteit (pp. 121-128). Heerlen: Open universiteit.

  6. Investigation into the acceptability of door locking to staff, patients, and visitors on acute psychiatric wards.

    Science.gov (United States)

    Muir-Cochrane, Eimear; van der Merwe, Marie; Nijman, Henk; Haglund, Kristina; Simpson, Alan; Bowers, Len

    2012-02-01

    There is disagreement among psychiatric professionals about whether the doors of acute psychiatric wards should be kept locked to prevent patients from leaving and harming themselves or others. This study explored patient, staff, and visitor perceptions about the acceptability of locking the ward door on acute psychiatric inpatient wards. Interviews were conducted with 14 registered nurses, 15 patients, and six visitors from three different acute wards. Findings revealed commonalities across all groups, with general agreement that locking the door reduced absconding. Staff expressed feelings of guilt, embarrassment, and fear of being blamed when a patient absconded. Staff also reported that open wards created anxious vigilance to prevent an abscond and increased workload in allocating staff to watch the door, whereas staff on partially-locked doors also perceived an increased workload in letting people in and out of the ward. Patients had mixed feelings about the status of the door, expressing depression, a sense of stigma, and low self-esteem when the door was locked. The issue of balancing safety and security on acute psychiatric wards against the autonomy of patients is not easily resolved, and requires focused research to develop innovative nursing practices. © 2011 The Authors. International Journal of Mental Health Nursing © 2011 Australian College of Mental Health Nurses Inc.

  7. 33 CFR 100.905 - Door County Triathlon; Door County, WI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Door County Triathlon; Door County, WI. 100.905 Section 100.905 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.905 Door County...

  8. 颈椎后路椎管扩大成形置入微型钛板:矢状面参数变化与修复效果的关系%Posterior cervical open-door expansive laminoplasty with mini-titanium plate:correlation between cervical sagittal alignment and repair effect

    Institute of Scientific and Technical Information of China (English)

    顾勇; 王强; 辛天闻; 杨惠林; 陈亮

    2016-01-01

    BACKGROUND:Posterior cervical open-door expansive laminoplasty is one of the simple and effective methods to treat cervical spinal diseases, has satisfactory results but low complications. However, the imbalance of sagittal plan, loss of lordosis or axial pain is often reported recently. OBJECTVE:To analyze the correlation between cervical sagittal alignment and clinical outcomes after laminoplasty. METHODS:Between January 2011 and June 2015, 122 cases of cervical spinal disease, who were treated with open-door expansive laminoplasty with mini-titanium plate, were retrospectively analyzed. Clinical outcomes were evaluated by Japanese Orthopaedic Association, Neck Disability Index and Visual Analogue Scale. Radiographic results were assessed by C2-7 Cobb angle, C2-7 sagittal vertical axis and C7 slope. The correlation between sagittal alignment and clinical outcomes were analyzed. RESULTS AND CONCLUSION:(1) Al patients were fol owed up for 7-32 months. (2) Japanese Orthopaedic Association, Neck Disability Index and Visual Analogue Scale scores were improved in the final fol ow-up (al P0.05). (4) These findings indicated that posterior cervical open-door expansive laminoplasty with mini-titanium plate can significantly improve the neurological function of patients. However, there is no correlation between cervical sagittal alignment and clinical outcomes.%背景:颈椎后路单开门椎管扩大成形术是治疗颈椎疾患的良好术式,具有临床疗效确切,操作相对简单,以及并发症少等优点。然而单开门术后颈椎矢状面失衡,前凸角度丢失或轴性痛等的报道并不少见。目的:探讨颈椎后路单开门椎管扩大成形微型钛板置入的疗效与矢状面参数变化之间的关系。方法:回顾性分析2011年1月至2015年6月采用单开门椎管扩大成形微型钛板置入治疗的122例颈椎疾患病例,利用日本骨科协会(JOA)评分、颈椎功能障碍指数及疼痛目测类比评分

  9. Discovery Mondays

    CERN Multimedia

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  10. 29 CFR 1917.114 - Cargo doors.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Cargo doors. 1917.114 Section 1917.114 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.114 Cargo doors. (a) Mechanically operated. (1) Cargo...

  11. Goedkopere weefselkweekplantjes door kweek in het donker

    NARCIS (Netherlands)

    Klerk, de G.J.M.

    2007-01-01

    Weefselkweek is duur. Daardoor zijn voordelen van weefselvermeerdering maar bij een klein aantal gewassen te benutten. Tot nu toe zijn de kosten teruggbracht door stoomlijnen van de productie en door overbrengen van de bulkproductie naar lagelonenlanden. Er zijn pogingen geweest het weefselkweekproc

  12. Outsourcing van het ICT door overheidsinstellingen

    NARCIS (Netherlands)

    Kok, L.; Theeuwes, J.J.M.; Janssens, L.

    2003-01-01

    Het IWI heeft onlangs gewezen op de risico’s van outsourcing van ICT door het UWV. Ook het uitbesteden van ICT door gemeenten is niet zonder risico. Om outsourcingsbeslissingen van gemeenten en UWV te kunnen beoordelen wil het ministerie meer inzicht in de effecten van outsourcing. De directie

  13. Do locked doors in psychiatric hospitals prevent patients from absconding?

    Directory of Open Access Journals (Sweden)

    Undine E. Lang

    Full Text Available Background and Objectives: In the acute treatment of acute psychiatric patients coercive measures are often required and therapeutic relationships can be affected by such measures. In this study we assessed whether opening the entrance door of an acute psychiatric ward influences absconding behaviour. Methods: An acute psychiatric ward was primarily closed (91.4% for six months and primarily open (75.6% for six months over the time period of one year. In this one year period, 337 patients were treated (206 male, age: 40 ± 16 years: 60.2% of the patients had schizophrenia, 13.6% had affective disorders, 11.6% suffered from addiction and 14.5% displayed other diagnoses. Results: In terms of age (t = 0.026, df = 335, p = 0.979, gender (chi² = 1.6, df = 1, p = 0.13, diagnoses (chi² = 7.337, df = 1, p = 0.062 and duration of stay (t = -0.90, df = 335, p = 0.928, we found no significant differences between the patients admitted in the closed and those admitted in the open ward period. Absconding (df = 1, chi² = 5.107, p = 0.029, aggressive incidents (chi² = 4.46, df = 1, p = 0.050 and coercive medications (chi² = 4.646, df = 1, p = 0.037 were observed significantly more often in the closed door period. Moreover, the duration up to readmission was reduced in the closed time period (t = 2.314, df = 54, p = 0.025. Conclusions: We hypothesize that open doors reduce patient's discomfort, improve ward atmosphere and aggressive acts and do not appear to increase the risk of absconding.

  14. 颈椎后路单开门手术对颈椎三维运动及刚性的影响%The effect of the expansive open-door laminoplasty on the three-dimensional motion and stiffness of the cervical spine

    Institute of Scientific and Technical Information of China (English)

    陈维善; 陈其昕; 王性力

    2001-01-01

    Objective To study the effect of the expansive open-door laminoplasty on the three-dimensional motion and stiffness of the cervical spine. Methods 55 cases after open-door laminoplasty of cervical spine due to myelopathy were follow-up for an average of 35.9 months. Cervical axial symptoms, neural functionality (JOA scoring system) and pre- and post-surgery dynamic cervical spine lateral X-ray films were evaluated. The Three-dimensional Motion and Stiffness of the Cervical Spine of Human Body Measuring Equipment was used in 12 post-operative open door laminoplasty cases and 10 pre-operative cases to measure the active and passive range of motion(ROM), load-displacement relationship, stiffness of cervical spine and torque caused by the isometric contraction of the extensors and flexors of the cervical spine. Results The average rate of improvement was 66. 2%. The excellent and good rate was 78.2%. The number of cases with distinct or severe cervical axial symptoms increased after the surgery ( P < 0. O1 ) . The patients who have severe axial symptoms tend to have less curved cervical spine (P < 0. 01 ) . There was no significant statistic difference between the severity of post-surgery cervical axial symptoms and JOA improvement level (P > 0. 05). The active and passive ROM of extension, rotation and lateral bending of cervical spine were decreased after the surgery ( P < 0. 05), and the main affection was on the middle and lower part of the cervical spine. The load-displacement figure of cervical spine can fit into an exponential equation T= b0eb1θ. In each direction, the lateral bending had the strongest stiffness, then the extension and flexion. The stiffness of rotation was the weakest. The stiffness of cervical spine of the post-surgery group was stronger than that of the contrast group. Conclusion The open-door laminoplasty of cervical spine damages the static mechanic balance on the sagittal plane and decreases the ROM and the flexibility of cervical

  15. An unexpected knock on Corrigan's secret door.

    Science.gov (United States)

    Woywodt, Alexander

    2010-10-01

    Corrigan's secret door describes a metaphorical escape route for busy physicians. The term was derived from the successful and exceptionally busy professional life of Irish physician Dominic John Corrigan (1802-80). It is claimed that Corrigan's outpatient clinic was so busy that he required a secret door in his consulting rooms to escape from the ever-growing queue of eager patients. The origins of this charming story are unknown, and the door may have never existed. However, at present, Corrigan's secret door is often quoted when busy physicians have their own little ways in surviving a stressful professional life. Generations of British-trained doctors have grown up with Corrigan's secret door, as it was featured in the introduction of the Oxford Handbook of Clinical Medicine. Accordingly, trainees as well as more senior doctors are often reminded that having a 'secret door' is vital in surviving in the medical profession. My own escape is through classical music and the violoncello, in particular. As the name implies, my own secret door is normally invisible to colleagues and patients. This little article is about a patient who found me out, and a reflection on the role of classical music and the cello in my professional life.

  16. The clinical effects of expansive unilateral open-door laminoplasty of the cervical spine with OsteoMed M3 plate and screws fixation%颈椎单开门椎管扩大成形术OsteoMed M3钉板固定的疗效

    Institute of Scientific and Technical Information of China (English)

    席新华; 吴强; 胡孔和; 包拥政; 李文俊; 何小龙; 朱文刚; 冯宗玉; 钟学仁

    2012-01-01

      目的总结颈椎单开门椎管扩大成形术中OsteoMed M3钉板内固定的效果.方法回顾性分析2007年10月至2011年2月汕头大学医学院附属粤北人民医院收治的20例颈椎病患者的临床资料,患者行颈椎单开门椎管扩大成形术并应用OsteoMed M3钉板固定;术后1周、12个月测量椎板开门角度和纤维性椎管矢状径(FSD),计算开门角度增加率和丢失率;术后3、12个月进行JOA评分并计算改善率;观察术后12个月轴性症状分级并计算其发生率.结果20例患者均顺利完成手术,未出现神经损伤、伤口感染等并发症.术后平均随访时间17.3个月.术后1周开门角度及FSD均明显较术前增加(P<0.05);术后12个月开门角度及FSD较术后1周有所降低,但仍明显高于术前(P<0.05).术后3、12个月JOA评分分别为(8.4±1.8)分、(11.0±2.4)分,与术前的(5.5±2.0)分比较,差异有统计学意义(P<0.05);术后3、12个月JOA改善率分别为(25±16)%、(48±22)%.术后12个月,5例(25%)患者出现轴性症状,其中可3例、差2例,经治疗后4例缓解、1例缓解不明显.结论OsteoMed M3钉板系统操作安全简单,可保证脊柱的稳定性.%  Objective To evaluate the clinical effects of OsteoMed M3 titanium plate and screws fixation in expansive unilateral open-door laminoplasty of the cervical spine. Methods From October 2007 to February 2011, 20 patients with cervical spondylosis were treated by expansive unilateral open-door laminoplasty using OsteoMed M3 plate and screws fixation at Yuebei People's Hospital Affiliated to Shantou University Medical College. The lamina open angle and fibrous sagittal diameter (FSD) were measured at 1 week and 12 months after operation, and the increase rate and loss rate of open angle were calculated. The Japanese Orthopaedic Association (JOA) scoring was applied to evaluate at 3, 12 months after operation, and JOA recovery rate was calculated. Axial symptom (AS) was

  17. A case of possessive state with onset influenced by 'door-to-door' sales.

    Science.gov (United States)

    Satoh, S; Obata, S; Seno, E; Okada, T; Morita, N; Saito, T; Yoshikawa, M; Yamagami, A

    1996-12-01

    Recently in Japan, 'door-to-door sales' has become of concern because it has created numerous legal and social problems. In this paper, a 47 year old dissociative trance disorder case who presented with possession by God is discussed. Specific types of door-to-door sales is known to use superstition and folk beliefs as tools to lure customers. In this particular case, these religious factors seemed to have played an important role in the precipitation of the disorder and its presentation. In addition, the brain-washing environment observed in video lectures used in door-to-door sales seemed to play an important role in the development of the possessive state. We also performed social psychiatric analysis of the occurrence of the possessive state in a city area, which has been considered to develop within traditional culture. Phenomenological classification by one of the authors was useful for diagnosing underlying disorders in the possessive state.

  18. Linear motor system for sliding door for 209-series 950-generation electric railcar; 209 kei 950 dai densha soku hikidoyo rinia motor system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-10

    The system named above has been delivered to East Japan Railway Co. by Fuji Electric Co., Ltd., for use aboard the railway company`s prototype car to close the sliding door and is now in test use, the car designed to carry both commuters and suburbanites. This is the first product of the linear motor-driven type intended to close the sliding door aboard a railway car. Some features are stated below. The door lock and the door lock disengagement unit are improved, with their reliability enhanced. TIMS (train information management system) control and transmission enable the opening and closing of the door, supervision over the individual door state, parameter rewriting, etc., from the driver`s cab. Some base boards are added for shortening the rigging process. It is planned that a 1-linear motor drive system will be manufactured, lighter in weight, lower in power consumption, enhanced in safety, and reduced in cost, for installation aboard the car. (NEDO)

  19. Vraaggericht werken door narratief onderzoek

    Directory of Open Access Journals (Sweden)

    Joos Meesters

    2010-09-01

    Full Text Available Narrative research as a means for demand-driven policy and interventions This article reports on the advantages of performing narrative research discovering need patterns of families, children, local residents regarding quality of the pedagogical climate in their neighbourhood. A need pattern is a constructed set of related questions and needs that people express in response to life events, concrete experiences or within their current habitat. A method for narrative analysis was developed for two applications: use as a research tool and use as a change management tool. In this method professionals assume the role of narrative researchers and simultaneously learn to listen to the demands and needs of their potential clients from a more objective perspective. The method has been developed while performing transdisciplinary narrative research in the town-area of Hatert in Nijmegen, which will be presented as an example case throughout the text. Vraaggericht werken door narratief onderzoek Dit artikel gaat in op de mogelijkheden van narratief onderzoek in het opsporen van vraagpatronen van gezinnen, kinderen, wijkbewoners met betrekking tot de kwaliteit van het opgroeiklimaat in hun wijk. Een vraagpatroon is een set van samenhangende vragen en behoeften die burgers uiten naar aanleiding van een levensgebeurtenis, een concrete ervaring of binnen de actuele context waar zij in leven. Voor deze vorm van onderzoek is een vraaganalyse-instrument ontwikkeld om deze vraagpatronen te identificeren. Dit instrument heeft een dubbel perspectief. Het is een onderzoeksinstrument en een veranderkundig instrument. De professional kruipt in de rol van onderzoeker en leert hiermee te luisteren naar de vragen en behoeften van burgers. Het instrument is ontwikkeld in en voor een transdisciplinair, narratief onderzoek in de wijk Hatert in Nijmegen, dat we als casus zullen presenteren.

  20. 微型钛板与锚定法颈椎单开门治疗颈椎病效果的对比研究%Mini titanium plate fixation versus anchor fixation in unilateral open-door laminoplasty for treatment of multilevel cervical myelopathy

    Institute of Scientific and Technical Information of China (English)

    温世锋; 郭东明; 徐中和; 肖文德; 李菊根; 尹庆水

    2013-01-01

    Objective To evaluate clinical efficacy of mini titanium plate fixation versus anchor fixation in unilateral open-door laminoplasty for treatment of multilevel cervical myelopathy (MCM).Methods A retrospective study of fifty-five patients with MCM who had undergone unilateral open-door laminoplasty was performed.Twenty-six patients underwent surgery with mini titanium plate fixation (A group)and twenty-nine patients with anchor fixation (B group) respectively.Clinical results were assessed by comparing the following parameters between patients who were in the two groups:Japanese Orthopaedic Association (JOA) score and JOA recovery rate,and image results were measured by Ishihara's curvature index,and area of the narrowest spinal canal and spinal cord in MRI.Results Fifty patients were followed up from 6 to forty-two months with an average of (27.1 ±9.9) months.No statistically significant differences were identified in follow-up JOA score and JOA recovery rate (P>0.05).A group had larger difference between the pre-and postoperative Ishihara's curvature index,area of the narrowest spinal canal and spinal cord (P<0.05).Conclusions Satisfactory recovery of neurological function can be achieved and maintained by the two fixations,however,A group had better image results than B group.%目的 比较颈椎单开门应用两种固定技术治疗多节段脊髓型颈椎病的的临床及影像学结果.方法 55例多节段脊髓型颈椎病患者,均进行颈椎单开门椎管扩大成形术,根据内固定技术分为微型钛板固定技术(A组)26例和锚定法固定技术(B组)29例.通过比较JOA评分及改善率评价临床疗效,而影像学结果则通过比较X线颈椎曲度变化值和MRI椎管与脊髓最狭窄处面积进行评估.结果 其中50例获得随访6~42个月,平均(27.1±9.9)个月.两组患者随访时JOA评分及改善率比较差异均无统计学意义(P>0.05);而在颈椎曲度变化值、椎管与脊髓最狭窄处面积变化

  1. Open-door laminoplasty for the treatment of failed anterior cervical spine surgery%单开门椎管扩大椎板成形术在颈椎病再手术中的应用及疗效分析

    Institute of Scientific and Technical Information of China (English)

    刘勇; 陈亮; 顾勇; 杨惠林; 唐天驷

    2010-01-01

    Objective To evaluate the outcome of open-door laminoplasty for the treatment of failed anterior cervical spine surgery. Methods From February 2003 to June 2009, 15 patients underwent opendoor laminoplasty for the failed anterior cervical spine surgery. The causes of revision and the progression of disease were analyzed. Japanese Orthopedic Association (JOA)scores and Nurick grade were adopted to record the improvement of neurological status and walking ability. Results Two patients were excluded for analysis because of lost follow-up and follow-up less than 12 months. The mean follow-up period after revision surgery for the other 13 patients was 26 months (ranged 13-52 months). The mean interval between the initial and revision surgery was 24 months ( ranged 5 months to 6 years). The causes of revision were as following: degeneration of the adjacent segment in 2 cases, inadequate decompression in 5 cases, misdiagnosis of ossification of posterior longitudinal ligament(OPLL) as myelopathy in 4 cases, and progression of OPLL in 2 cases. Posterior laminoplasty was recommended for each patient. After the operation,13 patients improved neurologically with respect to JOA score, 12 patients improved their walking ability while 1 remained unchanged. The mean modified JOA scores improved from 10. 5 to 13.8 ( P < 0. 05 ), the average recovery rate was 53.0% after the revision operation. The mean overall Nurick grade was 3.1 preoperatively and 1.9 at the final follow-up ( P < 0.05 ), the mean improvement of the Nurick grade was 1. 2. Complications included cerebrospinal fluid leakage in 1 case, new axial neck pain in 1 case, and transient C5 nerve root palsy in 1 case. Conclusions Open-door laminoplasty is a straightforward and effective treatment for failed anterior cervical spine surgery due to inadequate decompression, progressive OPLL or degeneration of the adjacent segment. The merit of the open-door laminoplasty for failed anterior spine fusion is able to avoid

  2. Early clinical efficacy of unilateral open-door cervical expansive laminoplasty plus centerpiece titanium plate fixation for cervical spinal stenosis%单开门颈椎管扩大成形Centerpiece钛板内固定术治疗颈椎管狭窄症的早期临床疗效

    Institute of Scientific and Technical Information of China (English)

    汪雷; 李涛; 宋跃明; 刘浩; 裴福兴; 刘立岷; 龚全; 孔清泉; 曾建成

    2011-01-01

    目的:探讨单开门颈椎管扩大成形Centerpiece钛板内固定术治疗颈椎管狭窄症的早期临床疗效.方法:2009年8月~2010年6月采用后路C3~C7单开门椎管扩大成形Centerpiece钛板内固定术治疗颈椎管狭窄症患者30例,其中男性23例,女性7例,年龄42~81岁,平均65.2岁.MRI显示3个节段狭窄9例,4个节段狭窄15例,5个节段狭窄6例.以JOA评分(17分法)及其改善率评价术后神经功能改善情况;术后复查颈椎X线、CT及MRI,在术前及术后3d、6个月的颈椎侧位X线片上测量C5节段椎管矢状径,计算椎管扩大率[(术后椎管矢状径-术前椎管矢状径)/(术前椎管矢状径)x 100%],评价椎管扩大和维持情况及门轴侧骨融合情况结果:手术时间为145±20min,术中出血量为215±75ml,术中未出现相关并发症.1例术后第2天出现C5神经根症状,经2周保守治疗疼痛明显缓解,术后2个月时症状完全消失.随访9~20个月,平均14.6个月,术前JOA评分为8.7±0.8分,术后6个月为15.2±1.1分,改善率为(75±18) %.影像学复查示术后3d、6个月时颈椎管扩大满意,脊髓受压完全解除,C5节段椎管矢状径术前为9.2±0.8mm,术后3d,6个月均为15.9±1.2mm,椎管扩大率为(71.8±11.0)%.术后6个月时门轴侧均达骨性愈合,无1例出现关门及神经损害症状加重的情况结论:单开门颈椎管扩大成形Centerpiece钛板内固定术是治疗颈椎管狭窄症的一种简便、安全的方法,早期疗效较满意.%Objective:To evaluate the early clinical efficacy of unilateral open-door cervical expansive laminoplasty plus centerpiece titanium plate fixation for cervical spinal stenosis. Method : From August 2009 to June 2010,30 cases suffering from cervical spinal stenosis underwent unilateral open-door expansive laminoplasty plus centerpiece fixation,of these,there were 23 males and 7 females,with a mean age of 65.2 years (range, 42-81 years ) .Preoperative MRI showed stenosis at three

  3. 49 CFR 571.206 - Standard No. 206; Door locks and door retention components.

    Science.gov (United States)

    2010-10-01

    ... can be loaded or unloaded. It does not include: (a) A trunk lid; or (b) A door or window composed... the door in the fully latched or secondary latched position. Trunk Lid is a movable body panel that... minimum displacement of 300 mm. (c) Two load cells of sufficient capacity to measure the applied loads...

  4. Electric two wheelers, zero emission solution for urban door to door transportation

    DEFF Research Database (Denmark)

    Fasil, Muhammed; Jensen, Bogi Bech

    The noise and exhaust pollution coupled with increasing congestion faced by urban centres demands new personal mobility solution for faster door to door connectivity. The advancement in electric power train and lowering cost of Li-ion battery is made it possible to develop light weight fully...

  5. New technology opens the door for deepwater development

    Institute of Scientific and Technical Information of China (English)

    Zhang Dagang

    2011-01-01

    The paper provided an updated status of technology for deepwater field development, demonstrated the importance of its application through actual project example, and discussed some future technical development trends. The focus was on the floating structures. By reviewing some of the engineering aspects of the project, the technology advancement, innovations and challenges in offshore engineering were discussed and demonstrated. The author's view of technical challenges facing deepwater forwarding was discussed, which covered water depth limitations, new material application, installation methods, riser development and operational issues. An overview of technologies that will enable deepwater projects to be extended into new frontiers was presented.

  6. The Door's Open: Educating Students Who Are Homeless

    Science.gov (United States)

    Delmore, Patrick

    2004-01-01

    Most often, homeless students are members of minority groups who have attended several schools during their school career, are from single-parent households, and have histories of irregular school attendance. These students also frequently suffer from physical and mental challenges that are rooted in poverty, lack access to medical care, and have…

  7. Sequoias, Mavericks, Open Doors...Composing Joan Tower

    Science.gov (United States)

    Allsup, Randall Everett

    2011-01-01

    This essay interview with Joan Tower is a meditation on the importance of composing, understood as a process larger than the making of new sound combinations or musical scores, suggesting that the compositional act is self-educative and self-forming. Tower's musical life, one of teaching and learning, one of composing and self-composing, is an…

  8. Doors open in South America by peace pact

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, A.

    2000-06-19

    Signing of a peace treaty between Peru and Ecuador in 1998, ending 50 years of border wars, has greatly improved the prospects for development in both countries. Within the last few months 19 joint electrification projects have been initiated and feasibility of a 270 km long cross-border pipeline is under active discussion. The pipeline project is expected to cost some US$400 million and take two years to build. Two Canadian companies, Alberta Energy Company (AEC) and SNC Lavalin will prepare the pipeline's technical study, while a third, Agra Earth and Environmental of Calgary, will prepare the environmental impact study. Another pipeline project in which AEC is also involved is under discussion. This project involves building the 290,000 barrel/day Oleoducto Crudo Pesado (OCP), estimated at US$700 million, which will transport blended heavy crude 500 km from the Oriente Basin in northeastern Ecuador to an offshore loading facility on the Pacific Coast at Balao. Construction of this second pipeline would allow Ecuador to double the oil it transports from 350,000 to 750,000 barrels/day. Ecuador is also making progress in modernizing its production facilities by encouraging private sector strategic alliances (In Ecuador petroleum is considered a national resource not to be exploited by private companies). Currently, Ecuador exports about 216,000 barrels/day and derives close to 50 per cent of its national income from oil exports.

  9. Opening Doors to Reading Building School-to-Work Skills

    CERN Document Server

    Fabry, Dee L

    2001-01-01

    This integrated, technology-based reading curriculum helps you build school-to-work skills in middle school learners-especially those who have reading difficulties. Based on a field-tested program (the STARR curriculum), it is specifically designed to meet student needs in the workplace and uses best practices research, SCANS foundations skills and competencies, and middle school research. Components include speaking, technology, analysis, reading, and research.

  10. Opening the door to coordination of care through teachable moments.

    Science.gov (United States)

    Berg, Gregory D; Korn, Allan M; Thomas, Eileen; Klemka-Walden, Linda; Bigony, Marysanta D; Newman, John F

    2007-10-01

    The challenge for care coordination is to identify members at a moment in time when they are receptive to intervention and provide the appropriate care management services. This manuscript describes a pilot program using inbound nurse advice calls from members to engage them in a care management program including disease management (DM). Annual medical claims diagnoses were used to identify members and their associated disease conditions. For each condition group for each year, nurse advice call data were used to calculate inbound nurse advice service call rates for each group. A pilot program was set up to engage inbound nurse advice callers in a broader discussion of their health concerns and refer them to a care management program. Among the program results, both the call rate by condition group and the correlation between average costs and call rates show that higher cost groups of members call the nurse advice service disproportionately more than lower cost members. Members who entered the DM programs through the nurse advice service were more likely to stay in the program than those who participated in the standard opt-in program. The results of this pilot program suggest that members who voluntarily call in to the nurse advice service for triage are at a "teachable moment" and highly motivated to participate in appropriate care management programs. The implication is that the nurse advice service may well be an innovative and effective way to enhance participation in a variety of care management programs including DM.

  11. Exit Tickets Open the Door to University Learning

    Science.gov (United States)

    Danley, Angela; McCoy, Ann; Weed, Rahila

    2006-01-01

    Four instructors from a mid-western university implemented exit tickets in their university courses. The exit tickets were based on Marzano's (2012) four types of exit tickets and were analyzed for patterns. Faculty completed a journal to reflect on what was learned examining the exit tickets. A survey was completed by both instructors and…

  12. Exit Tickets Open the Door to University Learning

    Directory of Open Access Journals (Sweden)

    Angela Danley, EdD

    2016-08-01

    Full Text Available Four instructors from a mid-western university implemented exit tickets in their university courses. The exit tickets were based on Marzano’s (2012 four types of exit tickets and were analyzed for patterns. Faculty completed a journal to reflect on what was learned examining the exit tickets. A survey was completed by both instructors and university students to determine the benefits of the use of exit tickets as a formative assessment at the university. Researchers share the processes used for implementing exit tickets and the results of the data collected along with implications for the use of exit tickets at the university.

  13. The Ancient Mosuo Open Their Doors to the World

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    THE Lugu River is located at the eastern edge of the Qinghai-Tibet Plateau, within Ninglang County, Yunnan Province in southwestern China. This mysterious river, found 2,680 meters above sea level and covering an area of 50 square kilometers, is known as the "bright pearl of the plateau." The area around the Lugu River is not only beautiful but also known for its unique local ethnic customs of the Naxi, Lisu and Yi inhabitants.

  14. Improving Technology Literacy: Does It Open Doors to Traditional Content?

    Science.gov (United States)

    Judson, Eugene

    2010-01-01

    This study investigated whether an identifiable link existed between gains in technology literacy and achievement in the areas of reading, mathematics, and language arts. Normal curve equivalent (NCE) content score changes from TerraNova assessments were calculated for approximately 5,000 students from fourth- to fifth-grade and 5,000 students…

  15. Opening Doors: Understanding School and Family Influences on Family Involvement

    Science.gov (United States)

    Carlisle, Erin; Stanley, Lindsey; Kemple, Kristen Mary

    2005-01-01

    Family involvement in schooling can benefit young children, teachers, and families. Family involvement in schools can be influenced by both school-related and family-related factors. School-related factors include teachers' attitudes toward families, and school and teacher expectations. Family-related factors include ethnicity, prior school…

  16. Childhood Fears and Worries: Opening the Doors to Conversation

    Science.gov (United States)

    Schreiber, Jean

    2012-01-01

    Although parents may try to shield their children from information that may be upsetting to them, inevitably they will be exposed to life's challenges and painful realities. People live in the "information age" and children are frequently bombarded with overwhelming news from the media. Since children are very aware of the emotions of the adults…

  17. Open Doors 1990/91: Report on International Educational Exchange.

    Science.gov (United States)

    Zikopoulos, Marianthi, Ed.; And Others

    This six-part report presents statistical data on worldwide trends in student mobility and migration, national origin, sources of financial support, fields of study, enrollments, and rates of growth. Part I explores the nature of student migration worldwide and presents data on the overall numbers of students going abroad and the extent to which…

  18. Opening Doors to Nursing Degrees: A Proposal from Ontario's Colleges

    Science.gov (United States)

    Colleges Ontario, 2010

    2010-01-01

    Ontario needs to expand nursing education options to improve access to the nursing profession, create better pathways amongst all nursing occupations, and build Ontario's capacity to meet the province's long-term nursing needs. Ontario's colleges are capable of playing a larger role within a long-term provincial strategy for sustaining and…

  19. Remedial-Math Workshop: Opening Doors to Graduation

    Science.gov (United States)

    Dabkowska, Ewa; Sosnovski, Bianca

    2016-01-01

    About half of students attending community colleges leave school before finishing their intended goals. To increase students' retention and to prevent the multiple-repeater problem, Queensborough Community College (QCC) offered a short-term workshop for remedial-mathematics students. This was another chance to exit remediation instead of repeating…

  20. Twitter and Facebook Open the Door to Collaboration

    Science.gov (United States)

    Huwe, Terence K.

    2012-01-01

    Building a social media profile itself is a rewarding experience for digital librarians, but there is another aspect to social media immersion, and it is a powerful tool for the profession. As librarians establish expert status in the use of popular tools such as Facebook, Twitter, Tumblr, and WordPress, they can add training and even product…

  1. The Globe opens its doors to the public

    CERN Multimedia

    2005-01-01

    The Globe of Science and Innovation has quickly become the most recognisable landmark on the CERN skyline. Since construction was completed last summer, the Globe's distinctive spherical shape has greeted and intrigued visitors and employees on arrival at CERN.

  2. Guided Discoveries.

    Science.gov (United States)

    Ehrlich, Amos

    1991-01-01

    Presented are four mathematical discoveries made by students on an arithmetical function using the Fibonacci sequence. Discussed is the nature of the role of the teacher in directing the students' discovery activities. (KR)

  3. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    The price discovery literature investigates how homogenous securities traded on different markets incorporate information into prices. We take this literature one step further and investigate how these markets contribute to stochastic volatility (volatility discovery). We formally show...... that the realized measures from homogenous securities share a fractional stochastic trend, which is a combination of the price and volatility discovery measures. Furthermore, we show that volatility discovery is associated with the way that market participants process information arrival (market sensitivity...

  4. Ballistic Missile Silo Door Monitoring Analysis

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; TROST,LAWRENCE C.

    2000-01-01

    This paper compares the cost and effectiveness of several potential options that may be used to monitor silo-based ballistic missiles. Silo door monitoring can be used to verify that warheads removed to deactivate or download silo-based ballistic missiles have not been replaced. A precedent for monitoring warhead replacement using reentry vehicle on site inspections (RV-OSIs) and using satellites has been established by START-I and START-II. However, other monitoring options have the potential to be less expensive and more effective. Three options are the most promising if high verification confidence is desired: random monitoring using door sensors; random monitoring using manned or unmanned aircraft; and continuous remote monitoring using unattended door sensors.

  5. WOODEN DOOR WINGS OF ADIYAMAN GREAT MOSQUE

    Directory of Open Access Journals (Sweden)

    Muhammet ARSLAN

    2010-06-01

    Full Text Available Woodworking which is in the most important Turk art branches have been used especially in Anatolia land readily. Wooden material that is seen on architectural units such as mimbar, ambo, wings of door and window, lectern has an important particularly with its ornamental figures. Wooden composition on the north and east doors of Adıyaman Great Mosque was built by Dulkadir Principality but regulated again in the last period of Ottoman Empire, is a theme which is exemined detailedly in Turk art. In this article, it is tried to determined ornamentel and tecnical characteristics of wooden door wings of Adıyaman Great Mosque belongs to early XX. century and the place of them in Turk art.

  6. Blower door measurements. Guide 'Airtightness-testing' for house owners and planners; Blower-Door-Messung. Leitfaden 'Gebaeudedichtigkeits-Pruefung' fuer Bauherren und Planer. Fachtext 3.4. Maerz 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    To determine the air tightness of the external envelope, blower door measurements are normally carried out. The thus determined integral figure for the complete structure is an insufficient basis for carrying out specific insulation procedures in existing buildings. Within the scope of the air tightness measurements with the blower door, additional measuring methods permit the determination of additional information on the leakage distribution and the leakage routes. The expanded measuring methods that are known from the bibliography 'opening a door' and 'adding a hole' as well as the new method of 'adding a hole plus' are explained, compared by means of exemplary measurements, and are considered for their suitability during field trials. [German] Zur Bestimmung der Luftdichtheit der Gebaeudehuelle werden im allgemeinen Blower Door-Messungen durchgefuehrt. Der hierbei bestimmte integrale Wert fuer das gesamte Gebaeude stellt fuer das Ergreifen von gezielten Abdichtungsmassnahmen im Gebaeudebestand eine zu geringe Basis dar. Weiterfuehrende Messmethoden erlauben, im Rahmen von Luftdichtheitsmessungen mit der Blower Door zusaetzliche Informationen ueber die Leckageverteilung und ueber Leckagewege zu bestimmen. Die aus der Literatur bekannten erweiterten Messmethoden 'Opening A Door' und 'Adding A Hole' sowie die neue Methode 'Adding A Hole Plus' werden erlaeutert, anhand von exemplarischen Messungen verglichen und im Feldeinsatz auf ihre Anwendbarkeit hin betrachtet.

  7. Treatment of Multi - segmental Cervical Spondylotic Myelopathy Treated Posterior Unilateral Open-door Laminoplasty Combined with Centerpiece Ttitanium Plate Internal Fixation%后路单开门 Centerpiece 内固定治疗多节段脊髓型颈椎病

    Institute of Scientific and Technical Information of China (English)

    胡勇; 董伟鑫; 赵红勇; 袁振山; 孙肖阳; 马维虎; 徐荣明

    2014-01-01

    Objective To explore the clinical effect and safty of posterior unilateral open-door laminoplasty combined with Centerpiece titanium plate internal fixation for multi-segmental cervical spondylotic myelopathy. Methods From May 2010 to May 2012,32 patients with multi-segmental cervical spondylotic myelopathy were treated by posterior unilateral open door laminoplasty combined with Centerpiece titanium plate internal fixation. There were 20 males and 12 females,with a mean age of(60. 4 ± 7. 6)years(ranged 49 to 77 years). The neurofunction was evaluated by Japan Orthopaedic Association(JOA) score. The cervical curvature angle(α)was demonstrated by the cross angle between posterior vertebral body margins of C2 and C7 on cervical radiographs. Calculated cervical range of motion according to the difference of the angle of α between hyperex-tension and hyperflexion cervical radiographs. Calculated shoulder and pain VAS scores assess the range of axial symptoms. Re-sults The operative time and intraoperative blood loss were respectively 140 min(100 ~ 160 min)and 460 mL(250 ~ 800) mL. All patients were followed up from 12 to 38 months with an median of 22 months. The JOA scores was(9. 26 ± 3. 16)be-fore surgery and(12. 95 ± 2. 35)at 1 week after surgery,which showed significant differences(P ﹤ 0. 05). The improve rate of Japanese Orthopaedic Association(JOA)scores was(56. 4 ± 9. 3)% . The JOA scores was(13. 30 ± 2. 46)3 months after surgery and(13. 16 ± 1. 39)1 year after surgery,there were no significant differences when compared with the JOA scores at 1 week after surgery(P ﹥ 0. 05). The cervical curvature angle were(18. 1 ± 3. 8)° before surgery an(16. 7 ± 5. 4)° 3 months after surgery. There were no significient differences(P ﹥ 0. 05). The cervical range of motion was(35. 46 ± 11. 54)° before surgery and(30. 65 ± 8. 95)° 3 months after surgery. There were no significient differences(P ﹥ 0. 05). The VAS scores were ((3. 8 ± 1. 8)before surgery

  8. 术前颈椎曲度与椎管扩大成形术后脊髓后移程度及疗效的相关性%Correlation between cervical curvature and spinal cord shift, surgical outcome after expansive open-door laminoplasty

    Institute of Scientific and Technical Information of China (English)

    朱继超; 刘晓光; 刘忠军; 姜亮; 韦峰; 于淼; 吴奉梁

    2013-01-01

    cervical curvature after expansive open-door laminoplasty for cervical myelopathy,and to investigate the relationship between cervical curvature and spinal cord shift.Methods:63 cases of cervical myelopathy undergoing traditional expansive open-door laminoplasty between January 2005 and December 2011 were reviewed retrospectively,the pathogenesis included cervical spondylotic myelopathy(26 cases),ossification of posterior longitudinal ligament(OPLL,20 cases) and developmental cervical spinal stenosis(17 cases).Traditional expansive open-door laminoplasty was performed because of multisegmental disc disease,multilevel OPLL or developmental cervical stenosis.All cases were divided into three groups according to the cervical curvature:the kyphosis group(n=16),the straight group(n=18) and the normal alignment group(n=29).The posterior shift of center of spinal cord(PCS) at each level of laminoplasty(C3-C7) was measured and calculated through the midsagittal images of MRI T2-weighted before and after surgery.Statistic analysis was performed to analyze the difference of PCS at each level (C3-C7) among three groups.The neurofunction for each patient was estimated by using the Japanese Orthopedic Association(JOA) score before surgery and at final follow-up,and the JOA recovery rate was calculated.Statistic analysis was performed to analyze the difference of the JOA recovery rate at final follow-up among three groups.Results:There was no statistical difference in the age,sex ratio,duration of symptoms,entity,follow-up time or the preoperative JOA score(P>0.05).Posterior migration of spinal cord was observed in all three groups,and there was no significant difference with respect to the mean PCS at C3-C7 level among three groups(P>0.05).The mean follow-up was 47±24(range 15-90) months,and the mean JOA recovery rate at final follow-up of each group was 59.81%,69.25% and 54.44% respectively,which showed no statistical difference(P>0.05).No linear correlation was found

  9. Maillard-reactie door model beheersbaar

    NARCIS (Netherlands)

    Roost, van M.

    2006-01-01

    Gewenste en ongewenste bruinkleuring van levensmiddelen door een Maillard-reactie is vaak lastig te beheersen. Wageningse onderzoekers ontwikkelden een simulatiemodel, waarmee producentenmeer inzicht krijgen in de Maillard-reactie, en zo ook de kleur van het eindproduct beter kunnen beheersen tijden

  10. Opnieuw sterfte van jonge bomen door woelmuizen

    NARCIS (Netherlands)

    Moraal, L.G.

    2002-01-01

    In het begin van de jaren negentig trad er behoorlijk veel schade op bij bosaanleg in het kader van de Randstadgroenstructuur en de set-aside regelingen in Groningen en Drenthe. De boompjes waren geplant op voormalige landbouwgrond. Door snelle verruiging van de vegetatie, ontstaat er voor woelmuize

  11. Schade door overstroming: Ervaringen uit New Orleans

    NARCIS (Netherlands)

    Kok, M.; Theunissen, R.; Jonkman, S.N.; Vrijling, J.K.

    2006-01-01

    Korte samenvatting van de overstromingen door hurricane Katrina in augustus 2005 in New Orleans en omgeving. Beschrijving van de effecten op het gebied en de bewoners, kwantitatieve inschatting van de gevolgend, en wat we hieruit voor Nederland kunnen leren. Uitgave met ondersteuning van het

  12. Zuivel en soep gezonder door logo

    NARCIS (Netherlands)

    Temme, E.H.M.

    2008-01-01

    Gezondheidslogo’s verspreiden zich door de schappen van de supermarkt. Het blauwe vinkje van de stichting Ik kies bewust en het klavertje vier van supermarkt Albert Heijn moeten zorgen voor een gezonder aanbod van voedingsmiddelen. Liesbeth Temme van RIKILT – Instituut voor voedselveiligheid onderzo

  13. Verspreiding van komkommerbontvirus (CGMMV) door vogels

    NARCIS (Netherlands)

    Stijger, I.; Hamelink, R.; Ludeking, D.J.W.

    2012-01-01

    Het komkommerbontvirus is een zeer persistent virus. De afgelopen jaren heeft het zich uitgebreid naar meerdere bedrijven. Door komkommertelers worden veel verschillende maatregelen op het gebied van hygiëne doorgevoerd om het virus uit de kas te houden of om verspreiding te voorkomen. Ondanks deze

  14. Pixel masks for screen-door transparency

    NARCIS (Netherlands)

    Mulder, J.D.; Groen, F.C.A.; Wijk, J.J. van

    1998-01-01

    Rendering objects transparently gives additional insight in complex and overlapping structures. However, traditional techniques for the rendering of transparent objects such as alpha blending are not very well suited for the rendering of multiple transparent objects in dynamic scenes. Screen-door tr

  15. Door grond horizontaal belaste palen: Bestaande ontwerpmodellen

    NARCIS (Netherlands)

    Hoefsloot, F.J.M.

    2008-01-01

    In het algemeen is een door grond horizontaal belaste paal een 3-D situatie, die in 1 fase direct met een 3-D EEM-model (zoals PLAXIS 3D Foundation) kan worden gemodelleerd. Deze modellen zijn echter gecompliceerd en pas de laatste jaren eenvoudiger toepasbaar in de adviespraktijk. Een directe berek

  16. Accuracy of the blower door measurement; Genauigkeit der Blower Door-Messung. Der Einfluss von Aussenklimaparametern

    Energy Technology Data Exchange (ETDEWEB)

    Weier, H. [Hochschule fuer Technik, Wirtschaft und Sozialwesen Zittau/Goerlitz (FH), Zittau (Germany)

    2000-04-01

    The blower door is a simple to use measuring device for determing the seal of the external surfaces of buildings. The accuracy of the measurement is dependent to a considerable extent on the external climatic conditions that prevail at the time of taking the measurement. (orig.) [German] Die Blower Door ist ein einfach anzuwendendes Messgeraet zum Bestimmen der Dichtheit von Gebaeudeaussenflaechen. Die Genauigkeit der Messung ist in starkem Masse von den zum Messzeitpunkt herrschenden Aussenklimabedingungen abhaengig. (orig.)

  17. 46 CFR 32.56-35 - Doors-T/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Doors-T/ALL. 32.56-35 Section 32.56-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS... Doors—T/ALL. (a) Casing doors in category A machinery spaces and all elevator doors must be self-closing...

  18. Nobel Prize in Physics 1993 "for the discovery of a new type of pulsar, a discovery that has opened up new possibilities for the study of gravitation" : Russell A. Hulse and Joseph H. Taylor Jr.

    CERN Multimedia

    1994-01-01

    Prof. J. H. Taylor Jr. presents "Binary pulsars and relativistic gravity" Spinning freely on their axes, and emitting radio noise detectable over interastellar distances, pulsars make extraordinarily stable natural clocks. Detailed comparisons of""pulsar time" with time kept by atomic clocks on Earth have opened the way for tests of gravity under conditions much more relativistic than found anywhere within the solar system. Among other results,these experiments have demonstrated the existence,quadrupolar nature, and propagation speed of gravitational waves.

  19. Comparison of short-term effect of two kinds of posterior internal fixation combined with ex-pansive open-door laminoplasty in the treatment of multilevel cervical myelopathy%两种后路内固定结合单开门手术治疗多节段脊髓型颈椎病的近期疗效比较

    Institute of Scientific and Technical Information of China (English)

    唐少龙; 黄庆华; 吴罗根; 周文华; 曹华敏; 陈大勇; 袁野

    2016-01-01

    目的:比较后路颈椎板成形术钉棒固定与微型钛板固定治疗多节段脊髓型颈椎病的近期疗效。方法将47例多节段脊髓型颈椎病患者随机分为两组:23例行后路颈椎板成形微型钛板固定术(微型钛板组),24例行后路颈椎板成形钉棒固定术(钉棒组)。比较两组手术时间、术中出血量、JOA评分、VAS评分、术后椎管矢状径、颈椎曲度、术后活动度影响及手术并发症等,评价两种手术方式的临床疗效。结果患者均获得随访,微型钛板组为(23.8±8.1)个月,钉棒组为(23.6±8.0)个月。两组手术时间、术中出血量、手术并发症比较差异无统计学意义(P>0.05)。 JOA评分:两组手术后均较术前显著升高(P<0.05),两组间比较差异无统计学意义(P>0.05)。颈痛VAS评分:术前钉棒组显著高于微型钛板组(P<0.05),术后两组评分均较术前显著降低(P<0.05),两组间比较差异无统计学意义(P>0.05)。颈椎矢状径:两组术后3 d和未次随访时均较术前明显改善(P<0.05),两组间比较差异无统计学意义(P>0.05)。术后3 d和末次随访时微型钛板组颈椎曲度改善明显优于钉棒组(P<0.05)。末次随访时两组活动度均较术前减少(P<0.05),钉棒组减少的度数明显大于微型钛板组( P<0.05)。结论后路颈椎板成形术钉棒固定与微型钛板固定治疗多节段脊髓颈椎病神经功能改善相似,微型钛板对颈椎的活动度影响较少。%Objective To compare the short-term clinical effect of posterior vertebral plate internal fixation combined with expansive open-door laminoplasty and posterior screw rod system fixation combined with expansive open -door laminoplasty in the treatment of multilevel cervical myelopathy .Methods Forty-seven cases with cervical spondylot-ic myelopathy were randomly divided into two groups:23 cases

  20. 一期后路单开门联合前路选择性减压融合术治疗多节段脊髓型颈椎病%One-stage Expansive Open-door Laminoplasty and Selective Anterior Decompression and Fusion for Multilevel Cervical Spondylotic Myelopathy

    Institute of Scientific and Technical Information of China (English)

    黄勇全; 刘先明; 黄华伟; 陈文明

    2012-01-01

    目的 评估一期后路单开门联合前路选择性减压治疗多节段脊髓型颈椎病的手术疗效.方法 对46例多节段(≥3节段)脊髓型颈椎病患者,均行后路单开门椎管成形+前路选择性椎体次全切除和(或)椎间盘切除椎间钛网、Cage或髂骨块植骨+前路钢板内固定术.术后测量颈椎曲度角评价颈椎排列,采用日本矫形外科学会(japanese orthopaedic association,JOA)评估系统评价其功能恢复情况,采用正侧位、动力位X线摄片和三维CT重建方法评估融合程度.同时,进行MRI检查,以观察脊髓减压程度和脊髓情况.结果 所有病例均获得平均24.1(12~28)个月的有效随访.JOA评分:术前为(9.0±1.2)分,术后6个月为(13.9±0.7)分,与术前比较,差异有统计学意义(P=0.007);末次随访为(14.1±0.6)分,与术前比较,差异有统计学意义(P=0.004).颈椎曲度角术前为(34.7±4.1)°,术后6个月为(37.1±5.1)°,术后6个月曲度角与术前比较,差异有统计学意义(P=0.024).术后12个月和末次随访,所有病例均已达到骨性融合,且椎管减压明显.结论 一期后路单开门联合前路选择性减压融合术是治疗多节段脊髓型颈椎病一种安全、有效的方法,在达到充分解除脊髓前后压迫的同时恢复颈椎排列,提高植骨融合率.%Objective To evaluate the curative efficacy of one-stage expansive open-door laminoplasty combined with selective anterior decompression and fusion in multilevel cervical spondylotic myelopathy. Methods Forty-six patients with multilevel cervical spondylotic myelopathy (≥3 consecutive segments) were treated with expansive open-door laminoplasty, selective anterior corpectomy,and (or) cervical reconstruction with titanium mesh cages,iliac bone graft,and anterior rigid plate fixation. The cervical curvature was determined to evaluate cervical spine arrangement. The functional recovery was assessed by Japanese orthopaedic association (JOA) scoring system

  1. Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

    Science.gov (United States)

    Rebollo-Lopez, María Jose; Lelièvre, Joël; Alvarez-Gomez, Daniel; Castro-Pichel, Julia; Martínez-Jiménez, Francisco; Papadatos, George; Kumar, Vinod; Colmenarejo, Gonzalo; Mugumbate, Grace; Hurle, Mark; Barroso, Vanessa; Young, Rob J.; Martinez-Hoyos, María; González del Río, Rubén; Bates, Robert H.; Lopez-Roman, Eva Maria; Mendoza-Losana, Alfonso; Brown, James R.; Alvarez-Ruiz, Emilio; Marti-Renom, Marc A.; Overington, John P.; Cammack, Nicholas; Ballell, Lluís; Barros-Aguire, David

    2015-01-01

    As a follow up to the antimycobacterial screening exercise and the release of GSK´s first Tres Cantos Antimycobacterial Set (TCAMS-TB), this paper presents the results of a second antitubercular screening effort of two hundred and fifty thousand compounds recently added to the GSK collection. The compounds were further prioritized based on not only antitubercular potency but also on physicochemical characteristics. The 50 most attractive compounds were then progressed for evaluation in three different predictive computational biology algorithms based on structural similarity or GSK historical biological assay data in order to determine their possible mechanisms of action. This effort has resulted in the identification of novel compounds and their hypothesized targets that will hopefully fuel future TB drug discovery and target validation programs alike. PMID:26642067

  2. Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.

    Directory of Open Access Journals (Sweden)

    María Jose Rebollo-Lopez

    Full Text Available As a follow up to the antimycobacterial screening exercise and the release of GSK´s first Tres Cantos Antimycobacterial Set (TCAMS-TB, this paper presents the results of a second antitubercular screening effort of two hundred and fifty thousand compounds recently added to the GSK collection. The compounds were further prioritized based on not only antitubercular potency but also on physicochemical characteristics. The 50 most attractive compounds were then progressed for evaluation in three different predictive computational biology algorithms based on structural similarity or GSK historical biological assay data in order to determine their possible mechanisms of action. This effort has resulted in the identification of novel compounds and their hypothesized targets that will hopefully fuel future TB drug discovery and target validation programs alike.

  3. Through the Door: A Passage to a New World and an Entrance to the Heart

    OpenAIRE

    Li, Yaqing

    2011-01-01

    This essay is around C.S Lewis’s classic children’s novel The Lion, the Witch and the Wardrobe and it focuses on the metaphorical meaning of the door and what insights it provides each time it is opened. It argues that the journey into Narnia is also a psychological journey, representing spiritual awakening. It draws conclusion that through this psychological journey in Narnia, the protagonists has undergone spiritual rebirth and their psyche has been raised to new heights.

  4. DoOR 2.0 - Comprehensive Mapping of Drosophila melanogaster Odorant Responses

    Science.gov (United States)

    Münch, Daniel; Galizia, C. Giovanni

    2016-02-01

    Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add unpublished data to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include all of these datasets into DoOR, provide a comprehensive update of both code and data, and new tools for data analyses and visualizations. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.

  5. DoOR 2.0--Comprehensive Mapping of Drosophila melanogaster Odorant Responses.

    Science.gov (United States)

    Münch, Daniel; Galizia, C Giovanni

    2016-02-25

    Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add unpublished data to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include all of these datasets into DoOR, provide a comprehensive update of both code and data, and new tools for data analyses and visualizations. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.

  6. Traumatic asphyxia--fatal accident in an automatic revolving door.

    Science.gov (United States)

    Cortis, J; Falk, J; Rothschild, M A

    2015-09-01

    Due to continuing modernisation, the number of automatic doors in routine use, including powered revolving doors, has increased in recent years. Automatic revolving doors are found mostly in department stores, airports, railway stations and hospitals. Although safety arrangements and guidelines concerning the installation of automatic doors are in existence, their disregard in conjunction with obsolete or incorrect installation can lead to fatal accidents. In this report, a 19-month-old boy is described whose right arm was caught between the elements of an automatic revolving door. As a direct result of rescue attempts, the child's body was drawn further into the narrow gap between elements of the door. To get the boy's body out of the 4-cm-wide gap between the fixed outer wall of the revolving door and the revolving inner, back-up batteries had to be disconnected so as to stop the electrical motor powering the door. Cardiopulmonary resuscitation was begun immediately after the rescue but was unsuccessful; the child was declared dead at the hospital he was taken to. The cause of death was a combination of compression-related skull and brain injury together with thoracic compression. This case shows an outstanding example of the preventive aspect as a special task of forensic medicine. Additionally, it serves as a warning for the correct installation and use of automatic revolving doors. Even so, small children should not use these doors on their own, but only with an alert companion, so as to prevent further fatal accidents of this sort.

  7. COMPARISON OF RESULTS OF THERMAL TESTS OF BALCONY DOORS

    Directory of Open Access Journals (Sweden)

    Golubev Stanislav Sergeevich

    2012-10-01

    Full Text Available Results of thermal tests of balcony doors are presented in the article. In the course of the research project, two types of doors were tested. The first type represents a PVC frame door (width 82 mm; it has a triple glazing (4K-16Ar-4-16Ar-K4; its blank part represents a polystyrene sandwich panel (width 40 mm. The second type represents a PVC frame door (width 82 mm, that has a triple glazing (4K-16Ar-4-16Ar-K4 and composite PVC panels. The testing procedure and processing results are described in the article. The test has demonstrated that the thermal resistance value of the balcony door of the first type exceeds the thermal resistance value of the balcony door of the second type.

  8. Design Report for ACP Hot Cell Rear Door

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; Kwon, K. C.; Choung, W. M.; Cho, I. J.; Kook, D. H.; Lee, W. K.; You, G. S.; Lee, E. P.; Park, S. W

    2005-12-15

    A hot-cell facility was constructed at the IMEF building for the demonstrate ACP process. ACP hot-cell consists of process cell and maintenance cell, and each cell has rear door. Since this facility was constructed at basement floor, all process materials, equipment and radioactive materials are take in and out through the rear door. Also, this door can be an access route of workers for the maintenance works. Therefore ACP hot-cell rear doors must maintain the radiation shielding, sealing, mechanical and structural safety. This report presents design criteria, design contents of each part and driving part. It was confirmed that the rear doors sufficiently maintain the safety through the structural analysis and shielding analysis. Also, it was confirmed that the rear doors were constructed as designed by the gamma scanning test after the installation.

  9. Stellar variability in open clusters. II. Discovery of a new period-luminosity relation in a class of fast-rotating pulsating stars in NGC 3766

    CERN Document Server

    Mowlavi, N; Semaan, T; Eggenberger, P; Barblan, F; Eyer, L; Ekström, S; Georgy, C

    2016-01-01

    $Context.$ Pulsating stars are windows to the physics of stars enabling us to see glimpses of their interior. Not all stars pulsate, however. On the main sequence, pulsating stars form an almost continuous sequence in brightness, except for a magnitude range between $\\delta$ Scuti and slowly pulsating B stars. Against all expectations, 36 periodic variables were discovered in 2013 in this luminosity range in the open cluster NGC 3766, the origins of which was a mystery. $Aims.$ We investigate the properties of those new variability class candidates in relation to their stellar rotation rates and stellar multiplicity. $Methods.$ We took multi-epoch spectra over three consecutive nights using ESO's Very Large Telescope. $Results.$ We find that the majority of the new variability class candidates are fast-rotating pulsators that obey a new period-luminosity relation. We argue that the new relation discovered here has a different physical origin to the period-luminosity relations observed for Cepheids. $Conclusio...

  10. Bodemverontreiniging en de opname van lood door moestuingewassen : risico’s van lood door bodemverontreiniging

    NARCIS (Netherlands)

    Otte, P.F.; Römkens, P.F.A.M.; Rietra, R.P.J.J.; Lijzen, J.P.A.

    2012-01-01

    Lood uit bodemverontreinigingen wordt opgenomen door moestuingewassen die daarop worden geteeld. Deze gewassen kunnen een gezondheidsrisico vormen als zij worden geconsumeerd. Uit deze studie van het RIVM en Alterra blijkt dat bij hoge concentraties lood in de bodem de opname minder wordt. Hierdoor

  11. Simplified multizone blower door techniques for multifamily buildings. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This research focused on the applicability of (a) two-blower-door and (b) single-blower-door multi-zone pressurization techniques for estimating the air leakage characteristics of New York State multi-family apartment buildings. The research also investigated the magnitude of external leakage area in multi-family buildings and used computer simulations to estimate the effect of decreasing external and internal leakage areas on air infiltration rates. This research investigates whether two blower doors can be used to determine the ELA of the exterior envelope and the ELA of partitions. Two multi-zone versions of the single-blower-door pressurization method are also examined.

  12. The mid-long-term influence of open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex on cervical physiological curvature and range of motion%保留颈后方韧带复合体单开门椎管扩大成形术后其颈椎生理曲度及活动范围的中远期随访

    Institute of Scientific and Technical Information of China (English)

    王磊; 王伟; 张永兴; 任龙喜

    2014-01-01

    Objectives: To study the mid-long-term influence of open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex on cervical physiological curvature and range of motion . Meth-ods: From January 2005 to January 2008, 20 patients undergoing open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex were reviewed retrospectively, the series consisted of 12 males and 8 females, aged 37-68 years(average, 52 years). The JOA score, alignment of the cervical spine and the ROM of the cervical spine were analyzed before and after operation respectively. Results: 20 patients were followed-up for a mean time of 7 years(range, 5-8 years). The mean JOA score was 9.5(7-13) before opera-tion. At final follow up, the mean JOA score was 14.0(9-17) and the recovery rate was 52%, which showed significant improvement(P0.05) compared with the preoperative(29°); and 7 degrees(5.5-19 degrees) for flexion, which showed significant difference(P0.05), and flexion position averaged 7°(5.5°-19° ), showing significant difference compared with the preoperative (16° , P<0.05). Replanted spinous process and the float laminae got bony fusion. No door re-closure was observed, and good vertebral canal maintaining was maintained. Conclusions: After open-door laminoplasty, the procedure of reconstruction of the posterior cervical ligamentous complex and the insertion of extensor to treat CSM will be helpful on maintaining the cervical physiological curvature, but it reduces the range of motion through the mid-long-term observation.%目的:观察保留颈后方韧带复合体重建伸肌附着点单开门椎管扩大成形术治疗脊髓型颈椎病对颈椎生理曲度、活动范围的中远期影响。方法:2005年1月~2008年1月采用保留颈后方韧带复合体联合重建伸肌附着点单开门椎管扩大成形术治疗脊髓型颈椎病20例患者,其中男性12例,女性8例,年龄37~68岁,平均52岁。比较

  13. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2015-01-01

    as their central concepts and conceptualization of the entrepreneurial function. On this basis we discuss three central themes that cut across the four alternatives: process, uncertainty, and agency. These themes provide new foci for entrepreneurship research and can help to generate new research questions......In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...

  14. Discovery of a general method of solving the Schrödinger and dirac equations that opens a way to accurately predictive quantum chemistry.

    Science.gov (United States)

    Nakatsuji, Hiroshi

    2012-09-18

    Just as Newtonian law governs classical physics, the Schrödinger equation (SE) and the relativistic Dirac equation (DE) rule the world of chemistry. So, if we can solve these equations accurately, we can use computation to predict chemistry precisely. However, for approximately 80 years after the discovery of these equations, chemists believed that they could not solve SE and DE for atoms and molecules that included many electrons. This Account reviews ideas developed over the past decade to further the goal of predictive quantum chemistry. Between 2000 and 2005, I discovered a general method of solving the SE and DE accurately. As a first inspiration, I formulated the structure of the exact wave function of the SE in a compact mathematical form. The explicit inclusion of the exact wave function's structure within the variational space allows for the calculation of the exact wave function as a solution of the variational method. Although this process sounds almost impossible, it is indeed possible, and I have published several formulations and applied them to solve the full configuration interaction (CI) with a very small number of variables. However, when I examined analytical solutions for atoms and molecules, the Hamiltonian integrals in their secular equations diverged. This singularity problem occurred in all atoms and molecules because it originates from the singularity of the Coulomb potential in their Hamiltonians. To overcome this problem, I first introduced the inverse SE and then the scaled SE. The latter simpler idea led to immediate and surprisingly accurate solution for the SEs of the hydrogen atom, helium atom, and hydrogen molecule. The free complement (FC) method, also called the free iterative CI (free ICI) method, was efficient for solving the SEs. In the FC method, the basis functions that span the exact wave function are produced by the Hamiltonian of the system and the zeroth-order wave function. These basis functions are called complement

  15. Sequestered spaces and defective doors in tales by Collins and Riddell

    Directory of Open Access Journals (Sweden)

    Ilse M. Bussing

    2012-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2012n62p99   In nineteenth-century texts the Victorian home is not merely asetting for supernatural activity—it is the protagonist. This articleconsiders how architecture engendered and shaped hauntedspace within Gothic texts by focusing on a single feature—the door—whose symbolic charge has been widely discussedby critics. However, instead of focusing on psychoanalyticor feminist notions commonly attached to this element, thisarticle considers architectural manuals of the day in order to“read” spatial and cultural implications of the door in Victorianhouseholds, arguing that an excessive concern for privacy andconcealment in life translates easily into Gothic fiction, in theform of spatial anxiety and infiltration. The discussion centerson two literary texts: The Dead Secret (1857 by Wilkie Collinsand The Open Door by Charlotte Riddell (1882.

  16. Door recognition in cluttered building interiors using imagery and lidar data

    Science.gov (United States)

    Díaz-Vilariño, L.; Martínez-Sánchez, J.; Lagüela, S.; Armesto, J.; Khoshelham, K.

    2014-06-01

    Building indoors reconstruction is an active research topic due to the importance of the wide range of applications to which they can be subjected, from architecture and furniture design, to movies and video games editing, or even crime scene investigation. Among the constructive elements defining the inside of a building, doors are important entities in applications like routing and navigation, and their automated recognition is advantageous e.g. in case of large multi-storey buildings with many office rooms. The inherent complexity of the automation of the recognition process is increased by the presence of clutter and occlusions, difficult to avoid in indoor scenes. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors using information acquired in the form of point clouds and images. The methodology goes in depth with door detection and labelling as either opened, closed or furniture (false positive)

  17. 3种颈椎后路单开门椎管扩大成形术的临床效果评价%Evaluation of the clinical effect of three kinds of cervical unilateral open-door laminoplasty in posterior access

    Institute of Scientific and Technical Information of China (English)

    卫秀洋; 陈勇忠; 王金星; 付桂红

    2014-01-01

    均无统计学意义(P=0.813,P=0.438)。⑤并发症。丝线固定组5例患者术后早期出现上肢麻木,给予地塞米松后缓解;锚钉固定组3例患者术后发热,给予解热镇痛药后缓解;钛板固定组2例患者发生脑脊液漏,3d后消失。所有患者的手术切口均甲级愈合,未发生锚钉脱出、钛板松动或断裂等并发症。结论:3种颈椎后路单开门椎管扩大成形术均能增加脊髓受压患者病变部位椎管面积、减小颈椎活动度和颈椎曲率指数、改善患者神经功能;与丝线悬吊固定相比,锚钉固定和微型钛板固定更加牢固,可有效防止再关门现象;微型钛板固定的疗效最好,但手术操作费时、创伤较大。%Objective:To observe the clinical curative effects and safety of three kinds of cervical unilateral open-door laminoplasty in posterior access.Methods:The medical records of 105 patients with multiple-segment cervical spinal cord compression were analyzed retro-spectively.The patients were treated with unilateral open-door laminoplasty and the open vertebral plates were fixed with suture silk(35 ), suture anchor(37)and micro titanium plate(33).The operative time,blood loss,hospital stay,JOA scores,minimal cross-sectional area of the vertebral canal,range of motion(ROM)of cervical vertebrae,cervical curvature index(CCI)and complications were compared between the 3 groups.Results:There was statistical difference in the operative time,blood loss and hospital stay between the 3 groups(68.4 +/-18.6,79.8+/-21.3,86.1 +/-25.9 min,F=13.560,P=0.000;346.3+/-85.7,364.1 +/-83.2,436.2+/-89.4 mL,F=14.317,P=0.000;53.3+/-4.8,52.4+/-3.7,32.4+/-4.5 d,F=19.492,P=0.000).The operative time and blood loss of titanium plate group were greater than those of the other 2 groups(P=0.000,P=0.000;P=0.000,P=0.000),while the hospital stay of titanium plate group was shorter than that of the other 2 groups(P=0.000,P=0.000).There was no statistical difference in the

  18. The particle at the end of the universe the hunt for the Higgs and the discovery of a new world

    CERN Document Server

    Carroll, Sean

    2012-01-01

    It was the universes most elusive particle, the linchpin for everything scientists dreamed up to explain how stuff works. It had to be found. But projects as big as CERN's Large Hadron Collider don't happen without dealing and conniving, incredible risks and occasional skullduggery. Award-winning physicist and science popularizer Sean Carroll reveals the history-making forces of insight, rivalry, and wonder that fuelled the Higgs search and how its discovery opens a door into the mind-boggling domain of dark matter and other phenomena we never predicted. Told with unrivalled ambition, authority, and access to the teams, this is the greatest science story of our time - riveting and irresistible.

  19. Routine Discovery of Complex Genetic Models using Genetic Algorithms.

    Science.gov (United States)

    Moore, Jason H; Hahn, Lance W; Ritchie, Marylyn D; Thornton, Tricia A; White, Bill C

    2004-02-01

    Simulation studies are useful in various disciplines for a number of reasons including the development and evaluation of new computational and statistical methods. This is particularly true in human genetics and genetic epidemiology where new analytical methods are needed for the detection and characterization of disease susceptibility genes whose effects are complex, nonlinear, and partially or solely dependent on the effects of other genes (i.e. epistasis or gene-gene interaction). Despite this need, the development of complex genetic models that can be used to simulate data is not always intuitive. In fact, only a few such models have been published. We have previously developed a genetic algorithm approach to discovering complex genetic models in which two single nucleotide polymorphisms (SNPs) influence disease risk solely through nonlinear interactions. In this paper, we extend this approach for the discovery of high-order epistasis models involving three to five SNPs. We demonstrate that the genetic algorithm is capable of routinely discovering interesting high-order epistasis models in which each SNP influences risk of disease only through interactions with the other SNPs in the model. This study opens the door for routine simulation of complex gene-gene interactions among SNPs for the development and evaluation of new statistical and computational approaches for identifying common, complex multifactorial disease susceptibility genes.

  20. Detecting Signage and Doors for Blind Navigation and Wayfinding.

    Science.gov (United States)

    Wang, Shuihua; Yang, Xiaodong; Tian, Yingli

    2013-07-01

    Signage plays a very important role to find destinations in applications of navigation and wayfinding. In this paper, we propose a novel framework to detect doors and signage to help blind people accessing unfamiliar indoor environments. In order to eliminate the interference information and improve the accuracy of signage detection, we first extract the attended areas by using a saliency map. Then the signage is detected in the attended areas by using a bipartite graph matching. The proposed method can handle multiple signage detection. Furthermore, in order to provide more information for blind users to access the area associated with the detected signage, we develop a robust method to detect doors based on a geometric door frame model which is independent to door appearances. Experimental results on our collected datasets of indoor signage and doors demonstrate the effectiveness and efficiency of our proposed method.

  1. Open Doors, Open Minds: Empowered Teachers Work and Learn Shoulder to Shoulder

    Science.gov (United States)

    Hudson, Marcia; Childs, Lauren; Carver, Cynthia L.

    2016-01-01

    In this article the authors share their experience of Teacher Lab, a job-embedded form of professional learning that has been a critical addition to professional learning practice for nearly a decade in the Avondale School District in Auburn Hills, Michigan. Using a full-day released time format, Teacher Lab combines preobservation dialogue and…

  2. ['Door de beugel': resorption at dental elements].

    Science.gov (United States)

    Leunisse, M; Barendrecht, D S

    2015-09-01

    A twenty-year-old man was referred to an orthodontist for orthodontic re-treatment of dental element 32 by his dentist and a periodontist. At the buccal surface of the dental element a significant gingival resorption had occurred and the root of the element was located outside of the processus alveolaris buccally. This case will be presented at the thematic tour 'Door de beugel: team up' on 27 October 2015, which is organised by the Nederlandse Vereniging van Tandartsen (Dutch Dentists' Society) and will be held at 4 different locations in the Netherlands. Readers of the Nederlands Tijdschrift voor Tandheelkunde get an exclusive preview of the case. The treatment of choice will be published in the December 2015 issue.

  3. Hazard Management with DOORS: Rail Infrastructure Projects

    Science.gov (United States)

    Hughes, Dave; Saeed, Amer

    LOI is a major rail infrastructure project that will contribute to a modernised transport system in time for the 2012 Olympic Games. A review of the procedures and tool infrastructure was conducted in early 2006, coinciding with a planned move to main works. A hazard log support tool was needed to provide: an automatic audit trial, version control and support collaborative working. A DOORS based Hazard Log (DHL) was selected as the Tool Strategy. A systematic approach was followed for the development of DHL, after a series of tests and acceptance gateways, DHL was handed over to the project in autumn 2006. The first few months were used for operational trials and he Hazard Management rocedure was modified to be a hybrid approach that used the strengths of DHL and Excel. The user experience in the deployment of DHL is summarised and directions for future improvement identified.

  4. Bidding to give in the field: door-to-door fundraisers had it right from the start

    NARCIS (Netherlands)

    Onderstal, S.; Schram, A.J.H.C.; Soetevent, A.R.

    2011-01-01

    In a door-to-door fundraising field experiment, we study the impact of fundraising mechanisms on charitable giving. We approached about 4500 households, each participating in either an all-pay auction, a lottery, a non-anonymous voluntary contribution mechanism (VCM), or an anonymous VCM. In contras

  5. Is Door-to-Door Canvassing Effective in Europe? Evidence from a Meta-study across Six European Countries

    DEFF Research Database (Denmark)

    Bhatti, Yosef; Dahlgaard, Jens Olav; Hansen, Jonas Hedegaard

    2016-01-01

    A vast amount of experimental evidence suggests that get-out-the-vote encouragements delivered through door-to-door canvassing have large effects on turnout. Most of the existing studies have been conducted in the United States, and are inspiring European mobilization campaigns. This article expl...

  6. Design and Analysis of Single Plate Blast Resistant Door

    Directory of Open Access Journals (Sweden)

    Nilesh S. Aitavade

    2013-06-01

    Full Text Available Blast Resistant Doors are used to withstand high intensity impulsive blast loads. They are designed to prevent the impact of the blast from travelling from one side to the other side of the door. Taking into account the limitations and the growing need of efficient blast resistant doors, a design was developed using ASTM A36 as the material of construction instead of concrete. Analytical calculations for the actual pressure-impulse loading condition were done as per the UFC 3-340-02, and the results of analytical calculations were compared with results of the simulation of the numerical model for the given boundary conditions.

  7. Global OpenSearch

    Science.gov (United States)

    Newman, D. J.; Mitchell, A. E.

    2015-12-01

    At AGU 2014, NASA EOSDIS demonstrated a case-study of an OpenSearch framework for Earth science data discovery. That framework leverages the IDN and CWIC OpenSearch API implementations to provide seamless discovery of data through the 'two-step' discovery process as outlined by the Federation for Earth Sciences (ESIP) OpenSearch Best Practices. But how would an Earth Scientist leverage this framework and what are the benefits? Using a client that understands the OpenSearch specification and, for further clarity, the various best practices and extensions, a scientist can discovery a plethora of data not normally accessible either by traditional methods (NASA Earth Data Search, Reverb, etc) or direct methods (going to the source of the data) We will demonstrate, via the CWICSmart web client, how an earth scientist can access regional data on a regional phenomena in a uniform and aggregated manner. We will demonstrate how an earth scientist can 'globalize' their discovery. You want to find local data on 'sea surface temperature of the Indian Ocean'? We can help you with that. 'European meteorological data'? Yes. 'Brazilian rainforest satellite imagery'? That too. CWIC allows you to get earth science data in a uniform fashion from a large number of disparate, world-wide agencies. This is what we mean by Global OpenSearch.

  8. Face Recognition Based Door Lock System Using Opencv and C# with Remote Access and Security Features

    Directory of Open Access Journals (Sweden)

    Prathamesh Timse

    2014-04-01

    Full Text Available This paper investigates the accuracy and effectiveness of the face detection and recognition algorithms using OpenCV and C# computer language. The adaboost algorithm [2] is used for face detection and PCA algorithm[1] is used for face recognition. This paper also investigates the robustness of the face recognition system when an unknown person is being detected, wherein the system will send an email to the owner of the system using SMTP [7]. The door lock can also be accessed remotely from any part of the world by using a Dropbox [8] account.

  9. Opto-mechanical door locking system

    Science.gov (United States)

    Patil, Saurabh S.; Rodrigues, Vanessa M.; Patil, Ajeetkumar; Chidangil, Santhosh

    2015-09-01

    We present an Opto-mechanical Door Locking System which is an optical system that combines a simple combination of a coherent light source (Laser) and a photodiode based sensor with focus toward security applications. The basic construct of the KEY comprises a Laser source in a cylindrical enclosure that slides perfectly into the LOCK. The Laser is pulsed at a fixed encrypted frequency unique to that locking system. Transistor-transistor logic (TTL) circuitry is used to achieve encryption. The casing of the key is designed in such a way that it will power the pulsing laser only when the key is inserted in the slot provided for it. The Lock includes a photo-sensor that will convert the detected light intensity to a corresponding electrical signal by decrypting the frequency. The lock also consists of a circuit with a feedback system that will carry the digital information regarding the encryption frequency code. The information received from the sensor is matched with the stored code; if found a perfect match, a signal will be sent to the servo to unlock the mechanical lock or to carry out any other operation. This technique can be incorporated in security systems for residences and safe houses, and can easily replace all conventional locks which formerly used fixed patterns to unlock. The major advantage of this proposed optomechanical system over conventional ones is that it no longer relies on a solid/imprinted pattern to perform its task and hence makes it almost impossible to tamper with.

  10. Ontwateren van zeugenmest door middel van omgekeerde osmose

    NARCIS (Netherlands)

    Thelosen, J.; Gastel, van J.; Cuyck, van J.

    1992-01-01

    In periodiek nummer 1 (februari 1991) is het proces van omgekeerde osmose reeds beschreven. In het kort komt omgekeerde osmose op het volgende neer: de te ontwateren vloeistof wordt onder hoge druk (55 bar) door filterbuizen gepompt.

  11. Rotational and frictional dynamics of the slamming of a door

    Science.gov (United States)

    Klein, Pascal; Müller, Andreas; Gröber, Sebastian; Molz, Alexander; Kuhn, Jochen

    2017-01-01

    A theoretical and experimental investigation of the rotational dynamics, including friction, of a slamming door is presented. Based on existing work regarding different damping models for rotational and oscillatory motions, we examine different forms for the (angular) velocity dependence (ωn, n = 0, 1, 2) of the frictional force. An analytic solution is given when all three friction terms are present and several solutions for specific cases known from the literature are reproduced. The motion of a door is investigated experimentally using a smartphone, and the data are compared with the theoretical results. A laboratory experiment under more controlled conditions is conducted to gain a deeper understanding of the movement of a slammed door. Our findings provide quantitative evidence that damping models involving quadratic air drag are most appropriate for the slamming of a door. Examining this everyday example of a physical phenomenon increases student motivation, because they can relate it to their own personal experience.

  12. Energiebesparing bij de bewaring van plantgoed van tulp door temperatuurintegratie

    NARCIS (Netherlands)

    Gude, H.; Dijkema, M.H.G.E.

    2006-01-01

    Onderzoek naar de mogelijkheden van TI (temperatuurintegratie) bij de bewaring van tulpenplantgoed door het vaststellen van de tolerantie van enkele cultivars voor verhogingen van de dagtemperatuur en verlagingen van de nachttemperatuur

  13. Epidemiologie en basisgezondheidszorg : analyse van volksgezondheid door basisgezondheidsdiensten

    NARCIS (Netherlands)

    Davidse, W.; Ginneken, J.K.S. van; Water, H.P.A. van de

    1989-01-01

    Dit boekje bevat de bijdragen aan het symposium, dat op 30 september 1988 werd georganiseerd door de sector Gezondheidszorg en Epidemiologie van het Nederlands Instituut voor Praeventieve Gezondheidszorg/TNO te Leiden.

  14. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  15. Fault Diagnosis Research for Metro Door Based on FTA%基于FTA的地铁车门故障诊断研究

    Institute of Scientific and Technical Information of China (English)

    夏军; 邢宗义; 王晓浩

    2014-01-01

    Door system is a key subsystem of metro train, so the FTA method is applied to carry out the fault diagnosis research for reducing door maintenance time and improving door reliability. On the basis of analyzing the structure and working principle of metro door system, the disabled open fault of door system is selected as a top event to establish the fault tree. The minimum cut set is calculated by the Fussell-Vesely method, then the qualitative and quantitative analysis of FTA are carried out, so , so it can be concluded that EDCU , limit switch, nut component , screw and middle unlocking component have a great damage on door disabled open fault. The obtained results can be used for fault diagnosis of the metro door system.%车门系统是地铁列车的关键子系统,应用故障树分析FTA方法对地铁车门系统进行故障诊断研究有助于缩短车门检修时间和提高车门工作可靠性。在分析地铁车门系统结构和工作原理的基础之上,选取车门无法自动开门故障作为顶事件建立故障树,采用下行法求最小割集并进行定性与定量的综合分析,从而得出了EDCU、关闭行程开关、螺母组件、丝杆和中间解锁组件对车门无法自动开门故障的影响较大的诊断结果,为地铁车门系统的故障诊断提供辅助参考决策。

  16. Blower-door techniques for measuring interzonal leakage

    Energy Technology Data Exchange (ETDEWEB)

    Hult, Erin L.; Sherman, Max H.; Walker, Iain

    2013-01-01

    Abstract The standard blower door test methods, such as ASTM E779, describe how to use a single blower door to determine the total leakage of a single-zone structure such as a detached single-family home. There are no standard test methods for measuring interzonal leakage in a two-zone or multi-zone building envelope such as might be encountered in with an attached garage or in a multifamily building. Some practitioners have been using techniques that involve making multiple measurements with a single blower door as well as combined measurements using multiple blower doors. Even for just two zones there are dozens of combinations of one-door and two-door test protocols that could conceivably be used to determine the interzonal air tightness. We examined many of these two-zone configurations using both simulation and measured data to estimate the accuracy and precision of each technique for realistic measurement scenarios. We also considered the impact of taking measurements at a single pressure versus over multiple pressures. We compared the various techniques and evaluated them for specific uses. Some techniques work better in one leakage regime; some are more sensitive to wind and other noise; some are more suited to determining only a subset of the leakage values. This paper makes recommendations on which techniques to use or not use for various cases and provides data that could be used to develop future test methods.

  17. Computational analysis of aircraft pressure relief doors

    Science.gov (United States)

    Schott, Tyler

    Modern trends in commercial aircraft design have sought to improve fuel efficiency while reducing emissions by operating at higher pressures and temperatures than ever before. Consequently, greater demands are placed on the auxiliary bleed air systems used for a multitude of aircraft operations. The increased role of bleed air systems poses significant challenges for the pressure relief system to ensure the safe and reliable operation of the aircraft. The core compartment pressure relief door (PRD) is an essential component of the pressure relief system which functions to relieve internal pressure in the core casing of a high-bypass turbofan engine during a burst duct over-pressurization event. The successful modeling and analysis of a burst duct event are imperative to the design and development of PRD's to ensure that they will meet the increased demands placed on the pressure relief system. Leveraging high-performance computing coupled with advances in computational analysis, this thesis focuses on a comprehensive computational fluid dynamics (CFD) study to characterize turbulent flow dynamics and quantify the performance of a core compartment PRD across a range of operating conditions and geometric configurations. The CFD analysis was based on a compressible, steady-state, three-dimensional, Reynolds-averaged Navier-Stokes approach. Simulations were analyzed, and results show that variations in freestream conditions, plenum environment, and geometric configurations have a non-linear impact on the discharge, moment, thrust, and surface temperature characteristics. The CFD study revealed that the underlying physics for this behavior is explained by the interaction of vortices, jets, and shockwaves. This thesis research is innovative and provides a comprehensive and detailed analysis of existing and novel PRD geometries over a range of realistic operating conditions representative of a burst duct over-pressurization event. Further, the study provides aircraft

  18. Pneumatic vs. door-to-door waste collection systems in existing urban areas: a comparison of economic performance.

    Science.gov (United States)

    Teerioja, Nea; Moliis, Katja; Kuvaja, Eveliina; Ollikainen, Markku; Punkkinen, Henna; Merta, Elina

    2012-10-01

    Pneumatic waste collection systems are becoming increasingly popular in new urban residential areas, and an attractive alternative to conventional vehicle-operated municipal solid waste (MSW) collection also in ready-built urban areas. How well pneumatic systems perform in ready-built areas is, however, an unexplored topic. In this paper, we analyze how a hypothetical stationary pneumatic waste collection system compares economically to a traditional vehicle-operated door-to-door collection system in an existing, densely populated urban area. Both pneumatic and door-to-door collection systems face disadvantages in such areas. While buildings and fixed city infrastructure increase the installation costs of a pneumatic system in existing residential areas, the limited space for waste transportation vehicles and containers cause problems for vehicle-operated waste collection systems. The method used for analyzing the cost effects of the compared waste collection systems in our case study takes into account also monetized environmental effects of both waste collection systems. As a result, we find that the door-to-door collection system is economically almost six times more superior. The dominant cost factor in the analysis is the large investment cost of the pneumatic system. The economic value of land is an important variable, as it is able to reverse the results, if the value of land saved with a pneumatic system is sufficiently high. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Achieving lipid goals with rosuvastatin compared with simvastatin in high risk patients in real clinical practice: a randomized, open-label, parallel-group, multi-center study: the DISCOVERY-Beta study

    Directory of Open Access Journals (Sweden)

    Toivo Laks

    2008-12-01

    Full Text Available Toivo Laks1, Ester Keba2, Mariann Leiner3, Eero Merilind4, Mall Petersen5, Sirje Reinmets6, Sille Väli7, Terje Sööt8, Karin Otter81Clinic of Internal Medicine, North-Estonia Regional Hospital, Tallinn, Estonia; 2Clinic of Internal Medicine, Viljandi County Hospital, Viljandi, Estonia; 3Mustamäe Family Doctors Centre, Tallinn, Estonia; 4Nõmme Family Doctors Centre, Tallinn, Estonia; 5Saku Health Centre, Saku, Estonia; 6Kristiine Family Doctors, Tallinn, Estonia; 7Family Doctor Sille Väli, Kuressaare, Estonia; 8AstraZeneca, Tallinn, EstoniaAbstract: The aim of this multi-center, open-label, randomized, parallel-group trial was to compare the efficacy of rosuvastatin with that of simvastatin in achieving the 1998 European Atherosclerosis Society (EAS lipid treatment goals. 504 patients (≥18 years with primary hypercholesterolemia and a 10-year cardiovascular (CV risk >20% or history of coronary heart disease (CHD or other established atherosclerotic disease were randomized in a 2:1 ratio to receive rosuvastatin 10 mg or simvastatin 20 mg once daily for 12 weeks. A significantly higher proportion of patients achieved 1998 EAS low-density lipoprotein cholesterol (LDL-C goal after 12 weeks of treatment with rosuvastatin 10 mg compared to simvastatin 20 mg (64 vs 51.5%, p < 0.01. Similarly, significantly more patients achieved the 1998 EAS total cholesterol (TC goal and the 2003 EAS LDL-C and TC goals (p < 0.001 with rosuvastatin 10 mg compared with simvastatin 20 mg. The incidence of adverse events and the proportion of patients who discontinued study treatment were similar between treatment groups. In conclusion, in the DISCOVERY-Beta Study in patients with primary hypercholesterolemia greater proportion of patients in the rosuvastatin 10 mg group achieved the EAS LDL-C treatment goal compared with the simvastatin 20 mg group. Drug tolerability was similar across both treatment groups.Keywords: hypercholesterolemia, low-density lipoprotein

  20. 14 CFR 29.783 - Doors.

    Science.gov (United States)

    2010-01-01

    ... specified in paragraph (d) of this section, acting separately relative to the surrounding structure. (2) The... ditching emergency exits must have means to enable them to be secured in the open position and remain secure for emergency egress in sea state conditions prescribed for ditching....

  1. SAFETY BULLETIN TIS 2002-03 GLASS DOORS

    CERN Multimedia

    2002-01-01

    Be careful! What happened?   Unsignaled reinforced glass.   Signaled safety glass.   A visitor recently hurt his leg when he walked into a glass door which shattered from the impact. This door was made of reinforced glass, a material which is inappropriate for this kind of use as it is too fragile. Indeed, it shatters into sharp splinters which can cause serious injury. Furthermore, the door was not easily visible (badly lit, no warning signs, ...). Corrective measures Just after the accident: glass doors were signed to make them more visible; replacement of dangerous glass panes planned for 2003. What preventive measures can be taken against this kind of accident? If you are in charge of projects and works: In the call for tender, specify the acceptable shock resistance level of the glass pane; Before the door is mounted, insist on receiving technical documentation and/or certificate of conformity from the supplier; If in doubt, ask advice from the TIS/GS sa...

  2. Biotechnology of polyketides: New breath of life for the novel antibiotic genetic pathways discovery through metagenomics

    Science.gov (United States)

    Gomes, Elisângela Soares; Schuch, Viviane; de Macedo Lemos, Eliana Gertrudes

    2013-01-01

    The discovery of secondary metabolites produced by microorganisms (e.g., penicillin in 1928) and the beginning of their industrial application (1940) opened new doors to what has been the main medication source for the treatment of infectious diseases and tumors. In fact, approximately 80 years after the discovery of the first antibiotic compound, and despite all of the warnings about the failure of the “goose that laid the golden egg,” the potential of this wealth is still inexorable: simply adjust the focus from “micro” to “nano”, that means changing the look from microorganisms to nanograms of DNA. Then, the search for new drugs, driven by genetic engineering combined with metagenomic strategies, shows us a way to bypass the barriers imposed by methodologies limited to isolation and culturing. However, we are far from solving the problem of supplying new molecules that are effective against the plasticity of multi- or pan-drug-resistant pathogens. Although the first advances in genetic engineering date back to 1990, there is still a lack of high-throughput methods to speed up the screening of new genes and design new molecules by recombination of pathways. In addition, it is necessary an increase in the variety of heterologous hosts and improvements throughout the full drug discovery pipeline. Among numerous studies focused on this subject, those on polyketide antibiotics stand out for the large technical-scientific efforts that established novel solutions for the transfer/engineering of major metabolic pathways using transposons and other episomes, overcoming one of the main methodological constraints for the heterologous expression of major pathways. In silico prediction analysis of three-dimensional enzymatic structures and advances in sequencing technologies have expanded access to the metabolic potential of microorganisms. PMID:24688489

  3. Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics

    Directory of Open Access Journals (Sweden)

    Elisângela Soares Gomes

    2013-12-01

    Full Text Available The discovery of secondary metabolites produced by microorganisms (e.g., penicillin in 1928 and the beginning of their industrial application (1940 opened new doors to what has been the main medication source for the treatment of infectious diseases and tumors. In fact, approximately 80 years after the discovery of the first antibiotic compound, and despite all of the warnings about the failure of the "goose that laid the golden egg," the potential of this wealth is still inexorable: simply adjust the focus from "micro" to "nano", that means changing the look from microorganisms to nanograms of DNA. Then, the search for new drugs, driven by genetic engineering combined with metagenomic strategies, shows us a way to bypass the barriers imposed by methodologies limited to isolation and culturing. However, we are far from solving the problem of supplying new molecules that are effective against the plasticity of multi- or pan-drug-resistant pathogens. Although the first advances in genetic engineering date back to 1990, there is still a lack of high-throughput methods to speed up the screening of new genes and design new molecules by recombination of pathways. In addition, it is necessary an increase in the variety of heterologous hosts and improvements throughout the full drug discovery pipeline. Among numerous studies focused on this subject, those on polyketide antibiotics stand out for the large technical-scientific efforts that established novel solutions for the transfer/engineering of major metabolic pathways using transposons and other episomes, overcoming one of the main methodological constraints for the heterologous expression of major pathways. In silico prediction analysis of three-dimensional enzymatic structures and advances in sequencing technologies have expanded access to the metabolic potential of microorganisms.

  4. Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics.

    Science.gov (United States)

    Gomes, Elisângela Soares; Schuch, Viviane; de Macedo Lemos, Eliana Gertrudes

    2013-12-01

    The discovery of secondary metabolites produced by microorganisms (e.g., penicillin in 1928) and the beginning of their industrial application (1940) opened new doors to what has been the main medication source for the treatment of infectious diseases and tumors. In fact, approximately 80 years after the discovery of the first antibiotic compound, and despite all of the warnings about the failure of the "goose that laid the golden egg," the potential of this wealth is still inexorable: simply adjust the focus from "micro" to "nano", that means changing the look from microorganisms to nanograms of DNA. Then, the search for new drugs, driven by genetic engineering combined with metagenomic strategies, shows us a way to bypass the barriers imposed by methodologies limited to isolation and culturing. However, we are far from solving the problem of supplying new molecules that are effective against the plasticity of multi- or pan-drug-resistant pathogens. Although the first advances in genetic engineering date back to 1990, there is still a lack of high-throughput methods to speed up the screening of new genes and design new molecules by recombination of pathways. In addition, it is necessary an increase in the variety of heterologous hosts and improvements throughout the full drug discovery pipeline. Among numerous studies focused on this subject, those on polyketide antibiotics stand out for the large technical-scientific efforts that established novel solutions for the transfer/engineering of major metabolic pathways using transposons and other episomes, overcoming one of the main methodological constraints for the heterologous expression of major pathways. In silico prediction analysis of three-dimensional enzymatic structures and advances in sequencing technologies have expanded access to the metabolic potential of microorganisms.

  5. Improving Door-to-balloon Time by Decreasing Door-to-ECG time for Walk-in STEMI Patients

    Directory of Open Access Journals (Sweden)

    Coyne, Christopher J.

    2014-12-01

    Full Text Available Introduction: The American Heart Association/American College of Cardiology guidelines recommend rapid door-to-electrocardiography (ECG times for patients with ST-segment elevation myocardial infarction (STEMI. Previous quality improvement research at our institution revealed that we were not meeting this benchmark for walk-in STEMI patients. The objective is to investigate whether simple, directed changes in the emergency department (ED triage process for potential cardiac patients could decrease door-to-ECG times and secondarily door-to-balloon times. Methods: We conducted an interventional study at a large, urban, public teaching hospital from April 2010 to June 2012. All patients who walked into the ED with a confirmed STEMI were enrolled in the study. The primary intervention involved creating a chief complaint-based “cardiac triage” designation that streamlined the evaluation of potential cardiac patients. A secondary intervention involved moving our ECG technician and ECG station to our initial triage area. The primary outcome measure was door-to-ECG time and the secondary outcome measure was door-to-balloon time. Results: We enrolled 91 walk-in STEMI patients prior to the intervention period and 141 patients after the invention. We observed statistically significant reductions in door-to-ECG time (43±93 to 30±72 minutes, median 23 to 14 minutes p<0.01, ECG-to-activation time (87±134 to 52±82 minutes, median 43 to 31 minutes p<0.01, and door-to-balloon time (134±146 to 84±40 minutes, median 85 -75 minutes p=0.03. Conclusion: By creating a chief complaint-based cardiac triage protocol and by streamlining ECG completion, walk-in STEMI patients are systematically processed through the ED. This is not only associated with a decrease in door-to-balloon time, but also a decrease in the variability of the time sensitive intervals of door-to-ECG and ECG-to-balloon time. [West J Emerg Med. 2015;16(1:184–189.

  6. Confounding adjustment through front-door blocking in longitudinal studies

    Directory of Open Access Journals (Sweden)

    Arvid Sjölander

    2013-03-01

    Full Text Available A common aim of epidemiological research is to estimate the causal effect of a particular exposure on a particular outcome. Towards this end, observed associations are often ‘adjusted’ for potential confounding variables. When the potential confounders are unmeasured, explicit adjustment becomes unfeasible. It has been demonstrated that causal effects can be estimated even in the presence of umeasured confounding, utilizing a method called ‘front-door blocking’. In this paper we generalize this method to longitudinal studies. We demonstrate that the method of front-door blocking poses a number of challenging statistical problems, analogous to the famous problems associ- ated with the method of ‘back-door blocking’.

  7. Simulation Optimization of the Crossdock Door Assignment Problem

    CERN Document Server

    Aickelin, Uwe

    2008-01-01

    The purpose of this report is to present the Crossdock Door Assignment Problem, which involves assigning destinations to outbound dock doors of Crossdock centres such that travel distance by material handling equipment is minimized. We propose a two fold solution; simulation and optimization of the simulation model simulation optimization. The novel aspect of our solution approach is that we intend to use simulation to derive a more realistic objective function and use Memetic algorithms to find an optimal solution. The main advantage of using Memetic algorithms is that it combines a local search with Genetic Algorithms. The Crossdock Door Assignment Problem is a new domain application to Memetic Algorithms and it is yet unknown how it will perform.

  8. The doors have been removed… for YOUR safety

    DEFF Research Database (Denmark)

    Abildgaard, Mette Simonsen

    A sociomaterial case study of how bombs (and their users), doors and politics instigated the destabilization and dismantling of the public telephone booth in Denmark, and the subsequent re-assembling process, through design contests and political struggle, to establish a new appropriate design...... Paper Long Abstract: This sociomaterial case study deals with the destabilization and dismantling of the public telephone booth in Denmark, which began in 1977-1978 when an unforeseen use - a series of bomb attacks - struck the booths in Copenhagen. As a safety measure, police removed the doors...

  9. Mind Mapping:The Key to the Door of Art Thinking%思维导图:打开美术思维之门的钥匙

    Institute of Scientific and Technical Information of China (English)

    严向红

    2012-01-01

      美术思维的训练与培养是中学美术教育的一道难题。思维导图就像一把打开美术思维之门的钥匙,在美术思维训练中发挥着特殊作用。思维导图的发散思维,可以打开学生想象创造之门;思维导图的全脑学习,可以打开学生的右脑直觉之门;思维导图的图文并茂,可以打开学生的绘画思维之门;思维导图与美育结合,可以打开学生的学科整合之门。%  The training and cultivation of art thinking is a problem of art education in middle schools. Mind map⁃ping is a key to the door of art thinking, and it plays a special role in the training of art thinking. First of all, the divergent thinking of mind mapping can open the door to students’imagination and creativity. Secondly, the whole brain learning of mind mapping can open the door to students’right-brain intuition. Thirdly, the illustrated mind mapping can open the door to students’painting thinking. Lastly, mind mapping coupled with aesthetic education can open the door to students’integration of subjects

  10. 钢管折叠门及铰链式插销设计%The Design of Steel-pipe Pull-down Door and Hinge-type latch

    Institute of Scientific and Technical Information of China (English)

    吴福明; 赵天婵

    2000-01-01

    介绍了一种钢管折叠门及铰链式插销的设计。该设计解决了门关闭时整体刚度差、门打开时存在死点的问题,可借助铰链式插销锁紧折叠门。%This article introduce a design of steel-pipe Pull-down door and hinge-type latch. This design preferably solves the technical problems when do designing the door in pre-design, such as integral rigidity being not very good, exciting fatal points when opening the door and so on. We can conveniently lock the pull-down doors by the hinge-type latch. The effect has been proved well by trial-manufacture and putting to use.

  11. Optimization of Circular Side Door Beam for Crashworthiness Analysis

    Directory of Open Access Journals (Sweden)

    Raja Sharmi Raja Husin

    2012-01-01

    Full Text Available Structural optimization related to crashworthiness and energy absorption capability is particularly importance to the automotive industry. The optimization involves highly nonlinear computational analysis and design with many material and structure parameters. This paper presents a crashworthiness design of the circular side door beam which attach to the side door structures. The response surface method (RSM is utilized to formulate the complex crashworthiness design problem in the case of optimization. In this study, side door beam will be optimized. The beams in circular shape were studied and compared. The focus is on finding an optimum cross-section shape of the beam in order to improve the energy absorption character.  An optimization problem is formulated to find the maximum energy absorbed with the maximum peak load as a constraint, the shape of the beam cross section and the thickness as variable. The structure optimum design and simulation analysis of automobile side-door beam was carried out by using Finite Element (FE method.

  12. 77 FR 62446 - Every Door Direct Mail-Retail

    Science.gov (United States)

    2012-10-15

    ... increase their marketing efforts. On July 10, 2012, the Postal Service filed a request with the Postal... alternative marketing name of Every Door Direct Mail for commercial mailings of Standard Mail flats with... positioning on the host piece. d. The attachment does not interfere with processing or delivery. Folded...

  13. De Rijnvervuiling door het ongeval bij Sandoz Ag

    NARCIS (Netherlands)

    Canton JH; van Gestel CAM; Greve PA; de Jong AP; Knoop J; de Kruijf HAM; van de Meent D; van Noort PCM; de Nijs T; Struijs J; Zwart; D. de

    1986-01-01

    Op basis van de door DBW/RIZA en het RIVM uitgevoerde metingen van de concentraties in Rijnwater van de bij Bazel geloosde bestrijdingsmiddelen zijn schattingen gemaakt van de maximale concentraties van deze stoffen in de Nederlandse oppervlaktewateren. Het betrof met name de stoffen disulfoton en

  14. Ontwikkeling van licht reflecterende deklagen door KWS: KonweBright

    NARCIS (Netherlands)

    ter Huerne, Henderikus L.; Hetebrij, Dirk; Elfring, Jan

    2014-01-01

    In het kader van het milieu staan op dit moment asfalt verhardingsmaterialen met sterker lichtreflecterende eigenschappen in de belangstelling. Dergelijke materialen hebben als voordeel dat door de verbeterde reflectie-eigenschappen op de wegen minder openbare verlichting nodig is en toch een goede

  15. DOORS English--The Cognitive Basis of Rhetorical Models.

    Science.gov (United States)

    Taylor, Karl K.

    1979-01-01

    The Development of Operational Reasoning Skills (DOORS) program at Illinois Central College is an interdisciplinary experiment that guides students from concrete to formal operational levels of thought to ensure that they understand the concepts and cognitive skills undergirding the rhetorical modes. (RL)

  16. Melkweg haarscherp in kaart door stabiele meetsystemen TNO

    NARCIS (Netherlands)

    Gielesen, W.L.M.

    2014-01-01

    Sinds enkele maanden draait de Ga¡a-satel]¡et van Esa op anderhalf miljoen kilometer van de aarde. Doel is om een zeer nauwkeurige driedimensionale kaart te maken van ongeveer een miljard sterren in ons Melkwegstetsel. Aan boord zijn twee meetsystemen, door TNO ontwikketd en gebouwd,

  17. Eerste kwartaal 2010 sierteelt: omzetgroei door herstel in maart

    NARCIS (Netherlands)

    Jukema, G.D.; Knijff, van der A.

    2010-01-01

    Het eerste kwartaal van 2010 begon door het winterse weer in januari slecht, maar eindigde hoopvol. Zowel in eigen land als op belangrijke exportmarkten remde winterse omstandigheden de aanvoer, verkoop en handel in bloemen en planten sterk. In februari en met name maart herstelde de aanvoer en mark

  18. A Scholar Who Knocks at the Door to Friendship

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Senegalese scholar Adama Gaye came from far away Africa to visit China in March when there was still a chill in the early spring air. He is not an ordinary scholar, but an African friend who has come to knock at the door to friendship.The government of Senegal established diplomatic relations

  19. Melkweg haarscherp in kaart door stabiele meetsystemen TNO

    NARCIS (Netherlands)

    Gielesen, W.L.M.

    2014-01-01

    Sinds enkele maanden draait de Ga¡a-satel]¡et van Esa op anderhalf miljoen kilometer van de aarde. Doel is om een zeer nauwkeurige driedimensionale kaart te maken van ongeveer een miljard sterren in ons Melkwegstetsel. Aan boord zijn twee meetsystemen, door TNO ontwikketd en gebouwd, verantwoordelij

  20. Schade aan gewassen door ozon in het groeiseizoen van 1994

    NARCIS (Netherlands)

    Tonneijck, A.E.G.; Dijk, van C.J.

    1995-01-01

    Op vier locaties is het effect van ozon op klaver (Trifolium subterraneum) en boon (Phaseolus vulgaris L.) onderzocht. Bij beide planten is substantiele bladbeschadiging door ozon op alle locaties waargenomen. Bij de teelt van gewassen moet rekening worden gehouden met de negatieve effecten van ozon

  1. Portal: Your Door to World Languages and Cultures

    Science.gov (United States)

    Elliott, Don; Lawton, Rachele

    2009-01-01

    Portal: Your Door to World Languages and Cultures was a series of public cultural events, in a variety of formats, created through a new partnership between the credit and continuing education (noncredit) foreign language programs at the Community College of Baltimore County (CCBC). Portal was designed to cultivate interest in foreign languages…

  2. ORIGINAL ARTICLES Door-to-needle time for administration of ...

    African Journals Online (AJOL)

    4 SAMJ. 241. Ischaemic heart disease (IHD) is a major cause of mortality and ... seen when the fibrinolytic is given within the first hour of symptom ... (AHA/ACC) guidelines recommend a door-to-needle time of .... The final number included in.

  3. Unconventional screening approaches for antibiotic discovery.

    Science.gov (United States)

    Farha, Maya A; Brown, Eric D

    2015-09-01

    The dramatic rise in microbial drug resistance in recent years has led to ongoing searches for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of new antibacterial drugs in discovery and development pipelines using traditional approaches has prompted a variety of unconventional and disruptive strategies for antibacterial drug discovery. Herein, we review recent nontraditional approaches that have been piloted for early drug discovery efforts. These unique methodologies open new avenues for finding the next generation of antimicrobials. © 2015 New York Academy of Sciences.

  4. Design of remote control system for vertical hinged door%户外遥控平开门控制系统设计

    Institute of Scientific and Technical Information of China (English)

    陈曼龙; 张琦

    2015-01-01

    It can facilitate people ’ s daily life to open or close vertical hinged door by way of remote control.The remote control system of the door is designed, with small power gear motors being installed at the bottom of hinged doors. This system uses PT2262/PT2272 remote control module, together with STC12C5A60S2 microcontroller, to control the door opening and closing;the infrared module is applied to as-sure personal or car security; the microcontroller receives signals from remote control module through timing interruption, and from infrared module through external interruption.Through the field test, the system can not only meet the requirements of opening and closing the outdoor double doors by remote control under various climate conditions, but also satisfy the economic requirements.%遥控启闭平开式户外庭院门实用便捷。通过在平开门下部安装小功率驱动电机,并利用STC12 C5 A60 S2单片机结合PT2262/PT2272遥控模块实现平开门遥控启闭,再使用红外模块进行车体和人身保护,单片机以定时中断方式接收遥控模块发出的指令,以外中断方式接受红外模块信号,设计了遥控平开门系统。经过现场测试,系统既能满足户外双扇门体在各种气候条件下的遥控启闭要求,又符合经济性要求。

  5. Door locking and exit security measures on acute psychiatric admission wards

    NARCIS (Netherlands)

    Nijman, H.L.I.; Bowers, L.; Haglund, K.; Muir-Cochrane, E.; Simpson, A.; Merwe, M. van der

    2011-01-01

    Locking the exit doors of psychiatric wards is believed to reduce the risk of patients absconding. The aims of the study were to investigate both the prevalence of door locking and other exit security measures on UK admission wards, as well as whether door locking appears to be effective in keeping

  6. 16 CFR 1211.13 - Inherent force activated secondary door sensors.

    Science.gov (United States)

    2010-01-01

    ... sensors. 1211.13 Section 1211.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT... § 1211.13 Inherent force activated secondary door sensors. (a) Normal operation test. (1) A force activated door sensor of a door system installed according to the installation instructions shall actuate...

  7. Environmental sustainability comparison of a hypothetical pneumatic waste collection system and a door-to-door system.

    Science.gov (United States)

    Punkkinen, Henna; Merta, Elina; Teerioja, Nea; Moliis, Katja; Kuvaja, Eveliina

    2012-10-01

    Waste collection is one of the life cycle phases that influence the environmental sustainability of waste management. Pneumatic waste collection systems represent a new way of arranging waste collection in densely populated urban areas. However, limited information is available on the environmental impacts of this system. In this study, we compare the environmental sustainability of conventional door-to-door waste collection with its hypothetical pneumatic alternative. Furthermore, we analyse whether the size of the hypothetical pneumatic system, or the number of waste fractions included, have an impact on the results. Environmental loads are calculated for a hypothetical pneumatic waste collection system modelled on an existing dense urban area in Helsinki, Finland, and the results are compared to those of the prevailing, container-based, door-to-door waste collection system. The evaluation method used is the life-cycle inventory (LCI). In this study, we report the atmospheric emissions of greenhouse gases (GHG), SO(2) and NO(x). The results indicate that replacing the prevailing system with stationary pneumatic waste collection in an existing urban infrastructure would increase total air emissions. Locally, in the waste collection area, emissions would nonetheless diminish, as collection traffic decreases. While the electricity consumption of the hypothetical pneumatic system and the origin of electricity have a significant bearing on the results, emissions due to manufacturing the system's components prove decisive. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. DSP-controIIed EIevator Door-motor System%DSP控制的电梯门机系统

    Institute of Scientific and Technical Information of China (English)

    翟朝朝; 黎庆发

    2015-01-01

    During opening and cIosing the eIevator door,it is required fast and smooth.By anaIyzing the mathematicaI modeI of permanent magnet synchronous motors,designed a zero d-axis current vector controI method.Pressing the eIevator door controI requirements,this articIe has designed a curve for the operation of the door,and used moduIe of MATLAB/SimuIink tobuiId simuIation modeIs.%电梯开门和关门过程要求快速平稳,因此通过分析永磁同步电机数学模型,设计了一套零d轴电流矢量控制系统。并按电梯门机运行要求,设计开关门速度曲线,用MATLAB/SimuIink模块搭建仿真模型验证控制方法。通过实验及现场调试运行,证明系统具有较好的鲁棒性和控制性能,满足电梯门机控制要求。

  9. The Cook and the Writer: Maryse Condé's Journey of Self-Discovery

    Directory of Open Access Journals (Sweden)

    Bonnie Thomas

    2013-07-01

    Full Text Available In her 2006 memoir, Victoire, les saveurs et les mots, (translated into English as Victoire: My Mother’s Mother, celebrated Guadeloupean writer Maryse Condé makes an explicit comparison between herself and her maternal grandmother Victoire. A work of literary invention as much as of personal reflection, this book represents an example of Condé’s quest to know herself as a woman and a writer. It also enables her to fill in some of the gaps left by her mother Jeanne who was always reluctant to share details of her childhood with her daughter and died when Condé was only twenty. One of the few facts Jeanne gives to her about Victoire is that she was a cook and that the results of her labour helped open the doors to greater autonomy for her daughter and, consequently, her granddaughter. This paper will examine the way in which food and cooking are linked to Condé’s journey of self-discovery as well as to the historical trajectory of the French Caribbean islands of Marie-Galante and Guadeloupe.

  10. From discovery to licensure, the Adjuvant System story

    Science.gov (United States)

    Garçon, Nathalie; Di Pasquale, Alberta

    2017-01-01

    ABSTRACT Adjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that could protect against new challenging pathogens such as HIV and malaria. New adjuvants and new combinations of adjuvants (Adjuvant Systems) have opened the door to the delivery of improved and new vaccines against re-emerging and difficult pathogens. Adjuvant Systems concept started through serendipity. The access to new developments in technology, microbiology and immunology have been instrumental for the dicephering of what they do and how they do it. This knowledge opens the door to more rational vaccine design with implications for developing new and better vaccines. PMID:27636098

  11. 一起电梯“门锁短接”的剖析%Analysis of a “Short Circuit of Door Lock” Elevator Accident

    Institute of Scientific and Technical Information of China (English)

    陈志莹

    2016-01-01

    The elevator landing door is the protection device for preventing falls and cut, the door lock device plays an important role in the safe operation of the elevator. According to statistics, more than 80% of accidents have occurred because of the elevator door system, and short circuit of door lock is a risk factor in such accidents. In this paper, a phenomena found in an elevator supervision and spot checks that the elevator continue to run while the elevator landing door opening is analyzed. Combining simple principle and practical means of the elevator industry, this paper discussed the short circuit of door lock based on this case, and warns the industry workers the harm of the shorting operation.%电梯层门是电梯中一种防止坠落和剪切的保护装置,门锁装置对电梯的安全运行起着至关重要的作用。据统计电梯事故的80%以上都发生在门系统中,而短接门锁又是此类事故的高危因素。本文对一起电梯监督抽查中发现的开门走梯现象进行了分析。文章借此案例以简单的原理结合行业中的实际操作手段来探讨门锁短接现象,并以此警示各位从业人员违规短接的危害。

  12. Portas abertas: novas possibilidades no ensino da enfermagem psiquiátrica Puertas abiertas: nuevas posibilidades en la enseñanza de la enfermería psiquiátrica Open doors: a new possibility in psychiatric nursing teaching

    Directory of Open Access Journals (Sweden)

    Eliana Aparecida Villa

    2000-12-01

    Full Text Available Este trabalho descreve uma experiência no ensino de enfermagem psiquiátrica, em um serviço aberto de atenção à saúde mental. Os discursos dos alunos mostram o sentido desse estágio para sua formação, apontando ter sido uma experiência rica a ser mantida, pois lhes permitiu conhecer o papel e a atuação do enfermeiro, desenvolver uma assistência contemplando teoria e prática, além de reconhecer o doente mental como cidadão.Este trabajo describe una experiencia en la enseñanza de la enfermería psiquiátrica en un servicio abierto de atención a la salud mental. Los relatos de los alumnos muestran el sentido de éstas prácticas para su formación profesional. Señalando la riqueza de ésta experiencia y el interés por su continuación ya que les permitió conocer el papel y la actuación del enfermero, desarrollar una asistencia teniendo en cuenta teoría y práctica, además de reconocer al enfermo mental como ciudadano.This paper describes a teaching experience in psychiatric nursing at an open mental health care service. Students' discourses show how meaningful and rich an experience it has been for their careers. Participating in this training has allowed them to learn the role of nurses, to improve assistance by applying both theory and practice as well as to recognize people with mental disorders as ordinary citizens.

  13. Usability of Discovery Portals

    NARCIS (Netherlands)

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals

  14. Usability of Discovery Portals

    NARCIS (Netherlands)

    Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.

    2013-01-01

    As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals

  15. Robotic Arm Camera Image of the South Side of the Thermal and Evolved-Gas Analyzer (Door TA4

    Science.gov (United States)

    2008-01-01

    The Thermal and Evolved-Gas Analyzer (TEGA) instrument aboard NASA's Phoenix Mars Lander is shown with one set of oven doors open and dirt from a sample delivery. After the 'seventh shake' of TEGA, a portion of the dirt sample entered the oven via a screen for analysis. This image was taken by the Robotic Arm Camera on Sol 18 (June 13, 2008), or 18th Martian day of the mission. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  16. Ervaringen van schaamte en psychologisch lijden door voedselbankklanten

    Directory of Open Access Journals (Sweden)

    Hille Hoogland

    2016-03-01

    men and 27 women. The interviews were transcribed verbatim and analysed in Atlas.ti by two researchers, using attribute and structural coding.Our results show that foodbank clients use a combination of different strategies to cope with living on tight budgets. Most of them save money on food, non-food and social activities. Another strategy is to ask for support from family or friends for money, clothing or food. Some respondents are almost completely dependent on gifts from friends and the food parcel and some also reported being restricted in their social life and having lost friends. We found that lack of money is related to psychological suffering: sleeplessness, stress, fear, panic, depression and feelings of sadness. The causes mentioned for this suffering were: debts, persistent letters from creditors, and not being able to afford consumer goods and/or activities. Some respondents reported seeking to numb these feelings through the use of alcohol or cannabis. Others avoided opening letters or answering telephone calls.In the interviews, foodbank clients expressed their feelings about their situation. Shame was the most frequently mentioned emotion and related to the label of “foodbank client”, the working method of the foodbank or not being able to consume what they wanted to. Firstly, respondents felt ashamed about being a foodbank client, because this is not acceptable in their social and cultural environment, and there is a negative stigma associated with being a foodbank client rather than a “normal working citizen”. Some of the respondents try to hide the fact that they use a foodbank, while others stated that they liked to form friendships with other foodbank clients because they would be more likely to accept and understand them. Another reaction was to downplay the situation. Secondly, shame was connected to the way that the foodbank operates. Clients feel ashamed to have to show their administration in the assessment interview before they can

  17. Intelligent Vision System for Door Sensing Mobile Robot

    Directory of Open Access Journals (Sweden)

    Jharna Majumdar

    2012-08-01

    Full Text Available Wheeled Mobile Robots find numerous applications in the Indoor man made structured environments. In order to operate effectively, the robots must be capable of sensing its surroundings. Computer Vision is one of the prime research areas directed towards achieving these sensing capabilities. In this paper, we present a Door Sensing Mobile Robot capable of navigating in the indoor environment. A robust and inexpensive approach for recognition and classification of the door, based on monocular vision system helps the mobile robot in decision making. To prove the efficacy of the algorithm we have designed and developed a ‘Differentially’ Driven Mobile Robot. A wall following behavior using Ultra Sonic range sensors is employed by the mobile robot for navigation in the corridors.  Field Programmable Gate Arrays (FPGA have been used for the implementation of PD Controller for wall following and PID Controller to control the speed of the Geared DC Motor.

  18. Improving Emergency Department Door to Doctor Time and Process Reliability

    Science.gov (United States)

    El Sayed, Mazen J.; El-Eid, Ghada R.; Saliba, Miriam; Jabbour, Rima; Hitti, Eveline A.

    2015-01-01

    Abstract The aim of this study is to determine the effectiveness of using lean management methods on improving emergency department door to doctor times at a tertiary care hospital. We performed a before and after study at an academic urban emergency department with 49,000 annual visits after implementing a series of lean driven interventions over a 20 month period. The primary outcome was mean door to doctor time and the secondary outcome was length of stay of both admitted and discharged patients. A convenience sample from the preintervention phase (February 2012) was compared to another from the postintervention phase (mid-October to mid-November 2013). Individual control charts were used to assess process stability. Postintervention there was a statistically significant decrease in the mean door to doctor time measure (40.0 minutes ± 53.44 vs 25.3 minutes ± 15.93 P < 0.001). The postintervention process was more statistically in control with a drop in the upper control limits from 148.8 to 72.9 minutes. Length of stay of both admitted and discharged patients dropped from 2.6 to 2.0 hours and 9.0 to 5.5 hours, respectively. All other variables including emergency department visit daily volumes, hospital occupancy, and left without being seen rates were comparable. Using lean change management techniques can be effective in reducing door to doctor time in the Emergency Department and improving process reliability. PMID:26496278

  19. Development of Automatically Handle Relief Agencies of Ventilation Door for Coal Mine%矿用风门自动卸压机构研制

    Institute of Scientific and Technical Information of China (English)

    李祖国; 孙晓磊

    2014-01-01

    Because of the negative pressure in the underground of Hegang coal mine Co., LTD, it is difficult to open the ventilation door.How to release the pressure while opening the ventilation door remains s technical problem.This design of two -way rotary shutters automatically handle relief agencies to address the difficult issues open throttle to achieve a relief , wrapped up in a short time to open the door , and convenient operation , and observed between two ventilation door , is able to watch the conditions in other channel , whether traffic , pedestrians , interlocking mechanism is normal.This device has broad market prospects.%黑龙江龙煤股份公司鹤岗分公司井下使用的风门,由于矿井通风负压关系影响,存在风门开启困难的问题。风门间如何实现开门卸压一直是该煤矿未能很好解决的技术难题。本文设计的双向手柄旋转式百叶窗自动卸压机构解决了风门开启困难的问题,实现了卸压、开门在短时间内一气呵成,并且操作快捷方便,同时又可兼做两道风门间嘹望窗使用,能够相互观看到另一道风门的状况,是否通车、行人、联锁机构是否正常。此装置具市场前景广阔。

  20. The self-organizing fractal theory as a universal discovery method: the phenomenon of life.

    Science.gov (United States)

    Kurakin, Alexei

    2011-03-29

    /phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter.The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.

  1. The self-organizing fractal theory as a universal discovery method: the phenomenon of life

    Directory of Open Access Journals (Sweden)

    Kurakin Alexei

    2011-03-01

    is an organizational state/phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter. The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.

  2. Open Days – The final countdown

    CERN Multimedia

    2008-01-01

    In only a few days CERN will open its doors to everyone! Thousands of volunteers are working very hard so that your visit will be both mind-boggling and fun. Where is the coldest place in the Universe? How can you move 30 tonne magnets with sub-millimetre precision? Why do you need huge detectors to look at the infinitely small? There’s only one way to find the answers: Come to CERN!

  3. A door-to-door survey of bed bug (Cimex lectularius) infestations in row homes in Philadelphia, Pennsylvania.

    Science.gov (United States)

    Wu, Yage; Tracy, Dylan M; Barbarin, Alexis M; Barbu, Corentin M; Levy, Michael Z

    2014-07-01

    We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012-2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes.

  4. Antiknock Performance of Interlayered High-Damping-Rubber Blast Door under Thermobaric Shock Wave

    Directory of Open Access Journals (Sweden)

    Xiudi Li

    2016-01-01

    Full Text Available The long duration and high impulse shock wave of thermobaric bomb threatens the security of underground structures. To obtain high resistance blast door against thermobaric shock wave, firstly, the dynamic mechanic property of high damping rubber was studied by split Hopkinson pressure bar (SHPB equipment and the stress-strain relationship of high damping rubber under average strain rate of 5200/s was obtained. Secondly, the numerical model of interlayered high-damping-rubber blast door was established with ANSYS/LS-DYNA code based on test results, and the antiknock performance of interlayered high-damping-rubber blast door under thermobaric shock wave was analyzed by contrast with ordinary blast door. The results showed that the midspan displacement of the blast door decreased firstly and then increased with the increase of thickness of the high-damping-rubber interlayer, and the optimal thickness of the high-damping-rubber interlayer for energy consuming was 150 mm in the calculation condition of this paper. With the increase of the distance between the interlayer and the front surface of the door, the midspan displacement of the blast door decreased continually. The midspan maximum displacement of interlayered high-damping-rubber blast door decreased 74.5% in comparison to ordinary blast door. It showed that the high-damping-rubber structure can effectively improve the antiknock performance of blast door under thermobaric shock wave.

  5. Computational drug discovery

    Institute of Scientific and Technical Information of China (English)

    Si-sheng OU-YANG; Jun-yan LU; Xiang-qian KONG; Zhong-jie LIANG; Cheng LUO; Hualiang JIANG

    2012-01-01

    Computational drug discovery is an effective strategy for accelerating and economizing drug discovery and development process.Because of the dramatic increase in the availability of biological macromolecule and small molecule information,the applicability of computational drug discovery has been extended and broadly applied to nearly every stage in the drug discovery and development workflow,including target identification and validation,lead discovery and optimization and preclinical tests.Over the past decades,computational drug discovery methods such as molecular docking,pharmacophore modeling and mapping,de novo design,molecular similarity calculation and sequence-based virtual screening have been greatly improved.In this review,we present an overview of these important computational methods,platforms and successful applications in this field.

  6. Reliable knowledge discovery

    CERN Document Server

    Dai, Honghua; Smirnov, Evgueni

    2012-01-01

    Reliable Knowledge Discovery focuses on theory, methods, and techniques for RKDD, a new sub-field of KDD. It studies the theory and methods to assure the reliability and trustworthiness of discovered knowledge and to maintain the stability and consistency of knowledge discovery processes. RKDD has a broad spectrum of applications, especially in critical domains like medicine, finance, and military. Reliable Knowledge Discovery also presents methods and techniques for designing robust knowledge-discovery processes. Approaches to assessing the reliability of the discovered knowledge are introduc

  7. Una puerta abierta a la profesionalidad pedagógica A door opened to pedagogical proficiency

    Directory of Open Access Journals (Sweden)

    Sonia Socarrás Sánchez

    2006-04-01

    Full Text Available Este trabajo es una experiencia pedagógica que se desarrolla en el Instituto Superior de Ciencias Médicas de Camagüey, se aplica desde el año 2003 y se extiende hasta este curso 2005-2006. Se tiene como base el trabajo desarrollado como profesor guía con el grupo D-11, F-16 y el testigo de primer año de Medicina, en los cuales se ha aplicado una estrategia pedagógica y a la misma se le adicionaron métodos educativos y un sistema de técnicas participativas, lo que ha dado resultados satisfactorios. El trabajo tiene como objetivo proponer una alternativa metodológica para el trabajo educativo del profesor guía en el proceso de fortalecimiento de los valores. El mismo brinda elementos teóricos relacionados con el trabajo educativo, diversos métodos y técnicas para realizar el mismo de manera más eficiente y se da a conocer la importancia del profesor guía en este proceso. Entre los resultados se destacan la formulación de pasos metodológicos para poder realizar una estrategia pedagógica, el diseño de una herramienta de trabajo para el profesor guía, indicaciones para efectuar el turno de reflexión y debate, la aplicación del material elaborado en la superación de los profesores guías que pertenecen al comité horizontal del primer año de medicinaThis work is a pedagogic experience developed in the High Medical School of Camaguey, it is applied since 2003 and it extends to the school year 2005-2006. It is based on the work developed by the adviser teachers of two groups and witness classes from first year, in which pedagogic strategies have been applied adding educational methods and a participative techniques system, with satisfactory results. This work has as objective to propose a methodological alternative for the advicer teachers´ educational work in the process of strengthen values. It offers theoretical elements related to the educational work, diverse methods and techniques to carry out it in a more efficient way, and it is showed the importance of the adviser teacher in the process. Among the results stand out the formulation of methodological steps to be able to carry out a pedagogic strategy, the design of a tool for the adviser teacher, indications to develop the debate and reflection shifts, the application of the material elaborated in the adviser teachers´ preparation in the first year horizontal committee.

  8. Flywheel bus opens doors for investors; Vliegwielbus opent deuren voor investeerders

    Energy Technology Data Exchange (ETDEWEB)

    Dijkgraaf, A. [ed.

    1999-03-01

    A brief impression is given of the performance of the first prototype of the CCM-developed (Centre for Construction and Mechatronics in Nuenen, Netherlands) flywheel bus, fuelled by LPG and powered by a flywheel

  9. The nutritional quality of drum-dried algae produced in open door mass culture.

    Science.gov (United States)

    Saleh, A M; Hussein, L A; Abdalla, F E; el-Fouly, M M; Shaheen, A B

    1985-12-01

    The yield of three large scale cultures of Scenedesmus acutus, Chlorella vulgaris, and Coelastrum proboscideum was drum dried. The amino acid composition of the three species proved to compare well with the FAO (11) amino acid pattern except for methionine and isoleucine. Bio-assay evaluation of the three algal proteins gave the following values: protein efficiency ratio, 1.9-2.1; net protein ratio, 2,4-2.8; biological value, 75-78; digestibility coefficient 88-89; and calculated net protein utilization 67-69. Total nucleic acid content was about 4%. Uric acid content in the plasma of rats fed Scenedesmus, Chlorella, and Coelastrum diets was significantly higher (P less than 0.05) than in plasma of rats fed on a casein diet.

  10. Single Cycle Thin Film Compressor Opening the door to Zeptosecond-Exawatt Physics

    CERN Document Server

    Mourou, G; Khazanov, E; Sergeev, A

    2014-01-01

    This article demonstrates a new compression scheme that has the potential to compress a high energy pulse as high as a few hundred Joules in a pulse as short as one optical cycle at 0.8{\\mu}m making a true ultra-relativistic {\\lambda}^3 pulse. This pulse could have a focused intensity of 10^24W/cm2 or a0 of 1000. It could form an efficient, 10%, relativistic mirror that could compress the pulse to the atto-zeptosecond regime, with an upshifted wavelength of 1-10keV. This technique could be a watershed making the entry of petawatt pulses into the exawatt and zeptosecond regime possible.

  11. Social Media: Opening New Doors for the Domestic Tourism Industry in Albania

    OpenAIRE

    Vjollca Hysi; Klodiana Gorica; Sokol Luzi

    2015-01-01

    The online word is becoming every day more and more important for the tourism industry. Through different technologies, it has made the possibility to ease the way people search and decide for their own travel destination, the way they pick their accommodation and their traveling medium. In particular the online social media, as part of the online word, has created new opportunities for interaction and communication between people. Today individuals have the opportunity to share ...

  12. Finding Difference: Nemo and Friends Opening the Door to Disability Theory

    Science.gov (United States)

    Preston, Daniel L.

    2010-01-01

    While middle school and high school students may have watched the Disney and Disney/Pixar films when they were younger, chances are they did not do so with a critical eye toward difference and disability, despite the fact that these films serve as excellent tools for teaching about difference. Recent estimates label 20% of the world's population…

  13. Examining the British PhD viva: opening new doors or scarring for life?

    Science.gov (United States)

    Carter, Bernie; Whittaker, Karen

    2009-01-01

    The PhD viva -- regardless of its format -- has the potential to be a significant rite of passage for the student. It is an experience that can resonate for months or years afterwards. Part of the challenge is that for everyone involved -- student, supervisory team and examiners -- a degree of end-point uncertainty exists. These ambiguities and tensions are perhaps an inherent part of any examination but are particularly characteristic of the examination of the individual and unique body of work that constitutes the doctoral thesis. In recent years, increased attention has been placed on the processes that surround the examination, aiming to increase transparency, consistency and fairness. However, the process of examining a student and their thesis remains challenging and is surrounded by different agendas, ideologies and practices. This paper examines some of the issues surrounding the PhD viva, primarily focusing on the British viva whilst weaving in commentary about the Australian system.

  14. Does United States v. Windsor (The DOMA Case Open the Door to Congressional Standing Rights?

    Directory of Open Access Journals (Sweden)

    Bradford C. Mank

    2015-06-01

    Full Text Available In rare cases, a president refuses to defend a statute based upon a belief that the statute is unconstitutional. The law is unclear whether either House of Congress has Article III standing to defend a statute that the president refuses to defend. In United States v. Windsor, the Supreme Court in 2013 addressed the onstitutionality of the Defense of Marriage Act (DOMA. The Obama Administration took the middle position of declining to defend DOMA, but still enforcing it, despite its view that the statute was unconstitutional to assist federal courts in reviewing the constitutionality of the statute. It was unclear whether an appeal was proper in the case once a district court held the statute was unconstitutional, and the Executive Branch essentially agreed with that decision. Applying both prudential standing principles and mandatory Article III standing rules, Justice Kennedy, writing for the majority, recognized that the Executive Branch was an appropriate party on appeal because it continued to enforce the statute. Additionally, the majority acknowledged that briefs filed by House of Representatives leadership supporting the constitutionality of DOMA supplied the necessary adverseness in the case given the Executive's view that DOMA was unconstitutional. The majority did not fully resolve the thorny issue of Congressional standing in cases where a president refuses to enforce a federal statute. Justice Scalia, in his dissent, emphasized the almost exclusive role of the Executive Branch in defending federal laws under Article II, squarely rejected Congressional standing, and argued that no party had standing to appeal in Windsor because the Executive agreed with the district court's judgment holding Section 3 unconstitutional. By contrast, Justice Alito, in his dissent, would have expressly recognized the authority and standing of the leaders of either House to defend any federal statute that the president does not defend. Yet by acknowledging that Congressional participation could supply the necessary adverseness to litigate a case when the Executive Branch agrees with the challenger that a statute is unconstitutional, the Court's opinion in Windsor likely will pave the way for increased Congressional participation in unusual cases where the Executive Branch believes a statute is unconstitutional, but at least one House of Congress wishes to defend the statute's constitutionality.

  15. Social Media: Opening New Doors for the Domestic Tourism Industry in Albania

    Directory of Open Access Journals (Sweden)

    Vjollca Hysi

    2015-04-01

    Full Text Available The online word is becoming every day more and more important for the tourism industry. Through different technologies, it has made the possibility to ease the way people search and decide for their own travel destination, the way they pick their accommodation and their traveling medium. In particular the online social media, as part of the online word, has created new opportunities for interaction and communication between people. Today individuals have the opportunity to share knowledge, opinions and experiences through online communication. Also their impact goes even further by influencing the behavior of other users in the process of buying. This article will be focused on the usage of Facebook social media platform, arranging a content analysis regarding the different social media tools to engage and interact. This will serve as small step in understanding how domestic business and tourism industry are using social platforms to engage more users and increase their business performance.

  16. Cell Culture in Microgravity: Opening the Door to Space Cell Biology

    Science.gov (United States)

    Pellis, Neal R.; Dawson, David L. (Technical Monitor)

    1999-01-01

    Adaptational response of human cell populations to microgravity is investigated using simulation, short-term Shuttle experiments, and long-term microgravity. Simulation consists of a clinostatically-rotated cell culture system. The system is a horizontally-rotated cylinder completely filled with culture medium. Low speed rotation results in continuous-fall of the cells through the fluid medium. In this setting, cells: 1) aggregate, 2) propagate in three dimensions, 3) synthesize matrix, 4) differentiate, and 5) form sinusoids that facilitate mass transfer. Space cell culture is conducted in flight bioreactors and in static incubators. Cells grown in microgravity are: bovine cartilage, promyelocytic leukemia, kidney proximal tubule cells, adrenal medulla, breast and colon cancer, and endothelium. Cells were cultured in space to test specific hypotheses. Cartilage cells were used to determine structural differences in cartilage grown in space compared to ground-based bioreactors. Results from a 130-day experiment on Mir revealed that cartilage grown in space was substantially more compressible due to insufficient glycosaminoglycan in the matrix. Interestingly, earth-grown cartilage conformed better to the dimensions of the scaffolding material, while the Mir specimens were spherical. The other cell populations are currently being analyzed for cell surface properties, gene expression, and differentiation. Results suggest that some cells spontaneously differentiate in microgravity. Additionally, vast changes in gene expression may occur in response to microgravity. In conclusion, the transition to microgravity may constitute a physical perturbation in cells resulting in unique gene expressions, the consequences of which may be useful in tissue engineering, disease modeling, and space cell biology.

  17. Keeping the door open: romantic science and the experience of self

    OpenAIRE

    Halliwell, Martin

    1996-01-01

    The thesis positions three modem thinkers working in different areas of the human sciences - William James, Ludwig Binswanger and Oliver Sacks - within a framework of romantic science. Romantic science is a term which is developed explicitly in the work of Sacks and also illuminates the central concerns of James and Binswanger. As such, romantic science provides a useful framework in which to discuss conceptual changes in the medical humanities (a branch of the human sciences directed to pati...

  18. Inclusion at University: Can we do more than open the door?

    Directory of Open Access Journals (Sweden)

    John O'Rourke

    2011-11-01

    Full Text Available Abstract The inclusion of students with Intellectual and Developmental Disabilities (IDD in university settings is an emerging policy initiative.  Different models have evolved to support the inclusion of students with IDD in university settings from full inclusion to specialized separate programs.  This paper reports the process of creating a program of inclusion for a student with IDD in a Western Australian university.   Based on extensive field notes and interviews with the included student and her mentors, the author seeks to assess the pilot study using a case study approach and reflect on what might be required by university staff to enhance inclusive practice for these students.   Key words:  Social inclusion, academic inclusion, university, inclusive pedagogy, intellectual and developmental disability.

  19. Opening the Door to Cloud-Cuckoo-Land: Hempel and Kuhn on Rationality

    Directory of Open Access Journals (Sweden)

    Alexander George

    2012-04-01

    Full Text Available A reading is offered of Carl Hempel’s and Thomas Kuhn’s positions on, and disagreements about, rationality in science that relates these issues to the debate between W.V. Quine and Rudolf Carnap on the analytic/synthetic distinction.

  20. "A Big Door Opened for Us": Parents' Perceptions of Comprehensive Preschool

    Science.gov (United States)

    DeMulder, Elizabeth K.; Stribling, Stacia M.

    2012-01-01

    This qualitative research study was designed to explore the perceptions of parents with low income regarding the effects of involvement in a comprehensive preschool program on their children's development and on the families' quality of life. A purposeful sample of parents who became actively involved in the preschool community was interviewed…

  1. Opening the Door: A First Look at the OCLC WorldCat Metadata API

    Directory of Open Access Journals (Sweden)

    Terry Reese

    2014-07-01

    Full Text Available Libraries have long relied on OCLC’s WorldCat database as a way to cooperatively share bibliographic data and declare library holdings to support interlibrary loan services. As curator, OCLC has traditionally mediated all interactions with the WorldCat database through their various cataloging clients to control access to the information. As more and more libraries look for new ways to interact with their data and streamline metadata operations and workflows, these clients have become bottlenecks and an inhibitor of library innovation. To address some of these concerns, in early 2013 OCLC announced the release of a set of application programming interfaces (APIs supporting read and write access to the WorldCat database. These APIs offer libraries their first opportunity to develop new services and workflows that directly interact with the WorldCat database, and provide opportunities for catalogers to begin redefining how they work with OCLC and their data.

  2. A Door Must Be Opened: Perceptions of Students with Disabilities in Higher Education

    Science.gov (United States)

    Yssel, Nina; Pak, Natalya; Beilke, Jayne

    2016-01-01

    Support services and legislation have contributed to the steady increase of students with disabilities in higher education. The question is whether obstacles that impeded success have been removed, or are students with disabilities still a marginalised group, deprived of the benefits of higher education? In this study we interviewed college…

  3. A Reggio-Inspired Music Atelier: Opening the Door between Visual Arts and Music

    Science.gov (United States)

    Hanna, Wendell

    2014-01-01

    The Reggio Emilia approach is based on the idea that every child has at least, "one hundred languages" available for expressing perspectives of the world, and one of those languages is music. While all of the arts (visual, music, dance, drama) are considered equally important in Reggio schools, the visual arts have been particularly…

  4. Opening the Door: How Community Organizations Address the Youth Unemployment Crisis. Executive Summary

    Science.gov (United States)

    Steinberg, Adria; Almeida, Cheryl

    2015-01-01

    Few Americans know the importance of community-based organizations, or CBOs, in helping tens of thousands of undereducated, underemployed young people find a job or go back to school. But the role of CBOs is growing more critical as the business, education, and philanthropic sectors increasingly recognize the need to enable the nation's millions…

  5. Keeping the door open: Exploring experiences of, and responses to, university students who disclose mental illness

    Directory of Open Access Journals (Sweden)

    Donna McAuliffe

    2012-06-01

    Full Text Available University educators increasingly manage situations where students disclose serious mental health issues. This is a significant issue, particularly for health and human service professions, as the importance of valuing the lived experience of mental illness lies alongside concerns for professional practice standards. Thus the responsibilities of students to disclose their mental health status and the responsibilities of Universities to provide appropriate support within established disability frameworks must be clear. However, students often do not know who they should disclose to, what will happen to disclosed information, and who has access to this information. Student's often fear embarrassment, stigma, and shame about disclosing mental illness, which is compounded by the diverse attitudes, experiences, and beliefs of educators. Consequently, this paper will review existing literature on university responses to, and students’ experiences of, mental illness in order to set a research agenda for this topic. The authors argue that such research must be undertaken urgently, in a context of inclusivity in higher education that gives voice to the experiences of students, their families and carers, university staff, and practitioners in the field.

  6. The three keys to quality customer service: opening the doors to exceptional performance.

    Science.gov (United States)

    Myers, Pennie; Nance, Don W

    2002-01-01

    Excellence in customer service requires three things. The first is a commitment to a set of principles. These principles reflect beliefs and assumptions that people are valuable and deserve to be treated with dignity and respect. This commitment is expressed to customers by an adherence to six customer-friendly processes and by personnel who possess a high level of skill in the behaviors that make up customer service. When these three requirements are met, laboratorians not only maintain a competitive edge but also fulfill their mission as health-care professionals.

  7. The U.S. Rebalance and Europe: Convergent Strategies Open Doors to Improved Cooperation

    Science.gov (United States)

    2014-06-01

    China trade deal with “some in Europe and elsewhere [who] want to shut China off behind a bamboo curtain of trade barriers.”28 Trade and invest- ment...July 2012 Phnom Penh statement, which “welcomed the central role played by ASEAN” and “an active and constructive role for China” in the Asia-Pacific

  8. Visy Cares Hub and Victoria University: Making the Door of a University Open to the Community

    Science.gov (United States)

    Broadbent, Robyn

    2011-01-01

    In 1999, a group of men embarked on a remarkable project that resulted in building a two million dollar youth centre in one of Melbourne's most disadvantaged communities. From the outset, Victoria University (VU) was a keen partner in the project. This project had key synergies with the current experiences of the University--a dual sector higher…

  9. Opening the Schoolhouse Doors: Tax Credits and Educational Access in Alabama

    Science.gov (United States)

    Carpenter, Dick M., II.; Erickson, Angela C.

    2014-01-01

    In 2013, Alabama adopted the Alabama Accountability Act, an education reform measure that includes two new school choice programs that extend a lifeline to Alabama students trapped in failing public schools. One program offers a tax credit to help offset the cost of tuition for families who move their children from public schools designated as…

  10. Cell Culture in Microgravity: Opening the Door to Space Cell Biology

    Science.gov (United States)

    Pellis, Neal R.; Dawson, David L. (Technical Monitor)

    1999-01-01

    Adaptational response of human cell populations to microgravity is investigated using simulation, short-term Shuttle experiments, and long-term microgravity. Simulation consists of a clinostatically-rotated cell culture system. The system is a horizontally-rotated cylinder completely filled with culture medium. Low speed rotation results in continuous-fall of the cells through the fluid medium. In this setting, cells: 1) aggregate, 2) propagate in three dimensions, 3) synthesize matrix, 4) differentiate, and 5) form sinusoids that facilitate mass transfer. Space cell culture is conducted in flight bioreactors and in static incubators. Cells grown in microgravity are: bovine cartilage, promyelocytic leukemia, kidney proximal tubule cells, adrenal medulla, breast and colon cancer, and endothelium. Cells were cultured in space to test specific hypotheses. Cartilage cells were used to determine structural differences in cartilage grown in space compared to ground-based bioreactors. Results from a 130-day experiment on Mir revealed that cartilage grown in space was substantially more compressible due to insufficient glycosaminoglycan in the matrix. Interestingly, earth-grown cartilage conformed better to the dimensions of the scaffolding material, while the Mir specimens were spherical. The other cell populations are currently being analyzed for cell surface properties, gene expression, and differentiation. Results suggest that some cells spontaneously differentiate in microgravity. Additionally, vast changes in gene expression may occur in response to microgravity. In conclusion, the transition to microgravity may constitute a physical perturbation in cells resulting in unique gene expressions, the consequences of which may be useful in tissue engineering, disease modeling, and space cell biology.

  11. International adoption has opened doors to a better life for many abandoned Chinese babies Going Home

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    On December 30, 2005, Jeannie Butler and her two daughters landed in China yet again. It was her 20th trip and she came loaded with boxes of clothing, food and toys meant for some of China's orphans. Several big boxes had already been dispatched before she boarded the plane. Butler has been doing this for the last 10 years.

  12. Taft's open door policy to the near east : dollar diplomacy practices in the ottoman empire

    OpenAIRE

    İplikçi, Murat

    2015-01-01

    Cataloged from PDF version of thesis. Includes bibliographical references (leaves 98-105) Thesis (M.S.): Bilkent University, Department of History, İhsan Doğramacı Bilkent University, 2015. This thesis analyzes the United States' Dollar Diplomacy and its practices towards the Ottoman Empire during William Howard Taft's presidency. The United States was not quite interested in improving its economic and diplomatic relations with the Ottoman Empire, before the reopen of the Ottoman Par...

  13. Religious Released Time Education: The Overlooked Open Door in Public Schools.

    Science.gov (United States)

    Ericsson, Samuel E.; And Others

    This paper presents arguments in favor of, and legal and constitutional guidelines for, religious released time education programs as a workable counterbalance for those concerned with the trend toward secularism in public education. The guidelines are necessarily general, because laws regarding the authority of school districts to adopt released…

  14. Opening the Door: A First Look at the OCLC WorldCat Metadata API

    OpenAIRE

    Terry Reese

    2014-01-01

    Libraries have long relied on OCLC’s WorldCat database as a way to cooperatively share bibliographic data and declare library holdings to support interlibrary loan services. As curator, OCLC has traditionally mediated all interactions with the WorldCat database through their various cataloging clients to control access to the information. As more and more libraries look for new ways to interact with their data and streamline metadata operations and workflows, these clients have become bottl...

  15. A Reggio-Inspired Music Atelier: Opening the Door between Visual Arts and Music

    Science.gov (United States)

    Hanna, Wendell

    2014-01-01

    The Reggio Emilia approach is based on the idea that every child has at least, "one hundred languages" available for expressing perspectives of the world, and one of those languages is music. While all of the arts (visual, music, dance, drama) are considered equally important in Reggio schools, the visual arts have been particularly…

  16. Opening the stable door: new initiatives at the Petrie Museum of Egyptian Archaeology

    Directory of Open Access Journals (Sweden)

    Sally MacDonald

    2000-11-01

    Full Text Available The Petrie Museum ut UCL contains u world-class collection of Egyptian objects that ranges chronologically from early prehistoric to Islamic times, but it is inadequately housed and remains little known outside Egyptology. It has now been designated us of national importance and its stuff have ambitious plans to provide greater access, via the Internet and in other ways, to the 80000 objects it contains.

  17. Video Conferencing for Opening Classroom Doors in Initial Teacher Education: Sociocultural Processes of Mimicking and Improvisation

    Directory of Open Access Journals (Sweden)

    Wiesemes, Rolf

    2010-01-01

    Full Text Available In this article, we present an alternative framework for conceptualising video-conferencing uses in initial teacher education and in Higher Education (HE more generally. This alternative framework takes into account the existing models in the field, but – based on a set of interviews conducted with teacher trainees and wider analysis of the related literature – we suggest that there is a need to add to existing models the notions of ‘mimicking’ (copying practice and improvisation (unplanned and spontaneous personal learning moments. These two notions are considered to be vital, as they remain valid throughout teachers’ careers and constitute key affordances of video-conferencing uses in HE. In particular, we argue that improvisational processes can be considered as key for developing professional practice and lifelong learning and that video-conferencing uses in initial teacher education can contribute to an understanding of training and learning processes. Current conceptualisations of video conferencing as suggested by Coyle (2004 and Marsh et al. (2009 remain valid, but also are limited in their scope with respect to focusing predominantly on pragmatic and instrumental teacher-training issues. Our article suggests that the theoretical conceptualisations of video conferencing should be expanded to include elements of mimicking and ultimately improvisation. This allows us to consider not just etic aspects of practice, but equally emic practices and related personal professional development. We locate these arguments more widely in a sociocultural-theory framework, as it enables us to describe interactions in dialectical rather than dichotomous terms (Lantolf & Poehner, 2008.

  18. NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry

    Directory of Open Access Journals (Sweden)

    Koichi Watashi

    2014-02-01

    Full Text Available Chronic hepatitis B virus (HBV infection, affecting approximately 240 million people worldwide, is a major public health problem that elevates the risk of developing liver cirrhosis and hepatocellular carcinoma. Given that current anti-HBV drugs are limited to interferon-based regimens and nucleos(tide analogs, the development of new anti-HBV agents is urgently needed. The viral entry process is generally an attractive target implicated in antiviral strategies. Using primary cells from humans and Tupaia belangeri, as well as HepaRG cells, important determinants of viral entry have been achieved. Recently, sodium taurocholate cotransporting polypeptide (NTCP was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection. This finding will allow a deeper understanding of the requirements for efficient HBV infection, including the elucidation of the molecular entry mechanism. In addition, pharmacological studies suggest that NTCP is able to serve as a therapeutic target. This article summarizes our current knowledge on the mechanisms of HBV entry and the role of NTCP in this process.

  19. Open Door for China's Auto——The 1st China Auto National Exhibition Tour

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ China Auto International Exhibition Tour was held for the first time as early as 1995,as an important pioneering undertaking.In fact,the first session of the tour was more appropriate to be called "National Exhibition Tour",as the tour team only traveled within China's borders.28 cars and motorcycles from China's four maior manufacturing groups took 20 days to travel around half of China.

  20. After the Doors Opened: Asking "Why" at a New Community College

    Science.gov (United States)

    Evenbeck, Scott; Merians, Linda E.

    2016-01-01

    This chapter describes some of the major principles, practices, and processes involved in designing and founding a new community college dedicated to improving student outcomes by doing things differently.

  1. Open doors: Library cross-sector co-operation in Bristol, UK

    OpenAIRE

    Chelin, J.

    2015-01-01

    Purpose\\ud \\ud – This paper outlines the aims, activities and outcomes of a project to pilot a reciprocal borrowing scheme between public and academic libraries using existing cards, i.e. public library cards in the academic library and university ID cards in the public libraries. \\ud \\ud Design/methodology/approach\\ud \\ud – This is a case study providing practical information about the establishment and promotion of the service, and recounting the feedback from surveys of participants, prosp...

  2. Australia's Migrants and Refugees: Opening the Door to Lifelong Learning. How Adults Learn a New Language.

    Science.gov (United States)

    Allender, Susan Chou

    A report examines the situation of adult education for immigrants and refugees in Australia. The first section situates the nation's immigration program within national economic development. The second section outlines the development of policy and programs relating to language and literacy education for migrants and refugees, and describes how…

  3. Hand sanitizer-dispensing door handles increase hand hygiene compliance: a pilot study.

    Science.gov (United States)

    Babiarz, Lukasz S; Savoie, Brent; McGuire, Mark; McConnell, Lauren; Nagy, Paul

    2014-04-01

    Improving rates of hand hygiene compliance (HHC) has been shown to reduce nosocomial disease. We compared the HHC for a traditional wall-mounted unit and a novel sanitizer-dispensing door handle device in a hospital inpatient ultrasound area. HHC increased 24.5%-77.1% (P sanitizer-dispensing door handle, whereas it remained unchanged for the other rooms. Technical improvements like a sanitizer-dispensing door handle can improve hospital HHC.

  4. Container lid gasket protective strip for double door transfer system

    Science.gov (United States)

    Allen, Jr., Burgess M

    2013-02-19

    An apparatus and a process for forming a protective barrier seal along a "ring of concern" of a transfer container used with double door systems is provided. A protective substrate is supplied between a "ring of concern" and a safety cover in which an adhesive layer of the substrate engages the "ring of concern". A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the "ring of concern" and the adhesive layer of the substrate.

  5. A review of the open charm and open bottom mesons

    CERN Document Server

    Chen, Hua-Xing; Liu, Xiang; Liu, Yan-Rui; Zhu, Shi-Lin

    2016-01-01

    Since the discovery of the first charmed meson in 1976, many open-charm and open-bottom mesons were observed. In 2003 two narrow charm-strange states $D_{s0}^*(2317)$ and $D_{s1}(2460)$ were discovered by the BaBar and CLEO Collaborations, respectively. After that, more excited heavy mesons were reported. In this work, we review the experimental and theoretical progress in this field.

  6. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...... their performance....

  7. Higgs Discovery Movie

    CERN Multimedia

    2014-01-01

    The ATLAS & CMS Experiments Celebrate the 2nd Anniversary of the Discovery of the Higgs boson. Here, are some images of the path from LHC startup to Nobel Prize, featuring a musical composition by Roger Zare, performed by the Donald Sinta Quartet, called “LHC”. Happy Discovery Day!

  8. Friends' Discovery Camp

    Science.gov (United States)

    Seymour, Seth

    2008-01-01

    This article features Friends' Discovery Camp, a program that allows children with and without autism spectrum disorder to learn and play together. In Friends' Discovery Camp, campers take part in sensory-rich experiences, ranging from hands-on activities and performing arts to science experiments and stories teaching social skills. Now in its 7th…

  9. Serendipity and Scientific Discovery.

    Science.gov (United States)

    Rosenman, Martin F.

    1988-01-01

    The discovery of penicillin is cited in a discussion of the role of serendipity as it relates to scientific discovery. The importance of sagacity as a personality trait is noted. Successful researchers have questioning minds, are willing to view data from several perspectives, and recognize and appreciate the unexpected. (JW)

  10. Empirical Discovery in Linguistics

    CERN Document Server

    Pericliev, V

    1995-01-01

    A discovery system for detecting correspondences in data is described, based on the familiar induction methods of J. S. Mill. Given a set of observations, the system induces the ``causally'' related facts in these observations. Its application to empirical linguistic discovery is described.

  11. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several promin

  12. Service Discovery At Home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent

  13. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several

  14. Service Discovery At Home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent

  15. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, Vasughi; Scholten, Hans; Jansen, Pierre; Hartel, Pieter

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several promin

  16. The Methodological Unboundedness of Limited Discovery Processes

    Directory of Open Access Journals (Sweden)

    John Benjamin Cassel

    2014-12-01

    Full Text Available Though designers must understand systems, designers work differently than scientists in studying systems.  Design engagements do not discover whole systems, but take calculated risks between discovery and intervention. For this reason, design practices must cope with open systems, and unpacking the tacit guidelines behind these practices is instructive to systems methodology. This paper shows that design practice yields a methodology which applies across forms of design.  Design practice teaches us to generate ideas and gather data longer, but stop when the return on design has diminished past its cost.  Fortunately, we can reason about the unknown by understanding the character of the unbounded.  We suppose that there might as well be an infinite number of factors, but we can reason about their concentration without knowing all of them.  We demonstrate this concept on stakeholder systems, showing how design discovery informs systems methodology. Using this result, we can apply the methods of parametric design when the parameters are not yet known by establishing the concentration of every kind of factor, entailing a discovery rate of diminishing returns over discovery activities, allowing the analysis of discovery-based trade-offs.  Here, we extend a framework for providing metrics to parametric design, allowing it to express the importance of discovery.

  17. Balancing Open Access with Academic Standards: Implications for Community College Faculty

    Science.gov (United States)

    Gabbard, Anita; Mupinga, Davison M.

    2013-01-01

    Community colleges act as the gateway for students to higher education. Many of these colleges realize this mission through open-door policies where students lacking in basic reading, writing, and mathematics skills can enroll. But, this open-access policy often creates challenges when meeting academic standards. Based on data collected from…

  18. Balancing Open Access with Academic Standards: Implications for Community College Faculty

    Science.gov (United States)

    Gabbard, Anita; Mupinga, Davison M.

    2013-01-01

    Community colleges act as the gateway for students to higher education. Many of these colleges realize this mission through open-door policies where students lacking in basic reading, writing, and mathematics skills can enroll. But, this open-access policy often creates challenges when meeting academic standards. Based on data collected from…

  19. "Eureka, Eureka!" Discoveries in Science

    Science.gov (United States)

    Agarwal, Pankaj

    2011-01-01

    Accidental discoveries have been of significant value in the progress of science. Although accidental discoveries are more common in pharmacology and chemistry, other branches of science have also benefited from such discoveries. While most discoveries are the result of persistent research, famous accidental discoveries provide a fascinating…

  20. Efetividade de um protocolo assistencial para redução do tempo porta-balão da angioplastia primária Effectiveness of a myocardial infarction protocol in reducing door-to-ballon time

    Directory of Open Access Journals (Sweden)

    Luis Cláudio Lemos Correia

    2013-01-01

    Full Text Available FUNDAMENTO: Tempo porta-balão adequado (BACKGROUND: An adequate door-to-balloon time (<120 minutes is the necessary condition for the efficacy of primary angioplasty in infarction to translate into effectiveness. OBJECTIVE: To describe the effectiveness of a quality of care protocol in reducing the door-to-balloon time. METHODS: Between May 2010 and August 2012, all individuals undergoing primary angioplasty in our hospital were analyzed. The door time was electronically recorded at the moment the patient took a number to be evaluated in the emergency room, which occurred prior to filling the check-in forms and to the triage. The balloon time was defined as the beginning of artery opening (introduction of the first device. The first 5 months of monitoring corresponded to the period of pre-implementation of the protocol. The protocol comprised the definition of a flowchart of actions from patient arrival at the hospital, the team's awareness raising in relation to the prioritization of time, and provision of a periodic feedback on the results and possible inadequacies. RESULTS: A total of 50 individuals were assessed. They were divided into five groups of 10 sequential patients (one group pre- and four groups post-protocol. The door-to-balloon time regarding the 10 cases recorded before protocol implementation was 200 ± 77 minutes. After protocol implementation, there was a progressive reduction of the door-to-balloon time to 142±78 minutes in the first 10 patients, then to 150±50 minutes, 131±37 minutes and, finally, 116±29 minutes in the three sequential groups of 10 patients, respectively. Linear regression between sequential patients and the door-to-balloon time (r = - 0.41 showed a regression coefficient of - 1.74 minutes. CONCLUSION: The protocol implementation proved effective in the reduction of the door-to-balloon time.

  1. Door to Door Survey and Community Participation to Implement a New County Mosquito Control Program in Wayne County, North Carolina, USA

    Directory of Open Access Journals (Sweden)

    Timothy Kelley

    2009-07-01

    Full Text Available Community involvement in mosquito management programs provides more sustainable and effective organization and service. A door to door survey in Wayne County, NC carried out by student volunteers, resulted in 60 household responses. Residents had not previously experienced outreach from the county (88%, and 95% of them thought the student door to door survey was an effective form of outreach. One third of the residents thought mosquitoes were severe where they lived, but only 9% thought they had any containers in their yard that might breed mosquitoes. Only 15% of the residents were concerned about mosquito borne diseases. These responses provide evidence that outreach and education on mosquito control and diseases were necessary steps for future mosquito control community planning.

  2. The prevalence and clinical features of restless legs syndrome: a door to door population study in Orhangazi, Bursa in Turkey.

    Science.gov (United States)

    Erer, Sevda; Karli, Necdet; Zarifoglu, Mehmet; Ozcakir, Alis; Yildiz, Demet

    2009-01-01

    Restless leg syndrome (RLS) has negative effects on the quality of life of the patients. Epidemiological studies on RLS are limited. To determine the prevalence of RLS among people aged 40 years and above in Orhangazi district of Bursa, Turkey. The study was carried out between 2004 and 2005. This population-based study was conducted in two phases. In the phase 1, residents conducted door-to-door interviews using a short questionnaire to determine the possible cases of RLS. In the phase 2, physicians ascertained the suspected cases of RLS. Diagnosis of RLS was made using the criteria proposed by the International Restless Legs Syndrome Study Group (IRLSSG) and also the rating scale for RLS. Out of 1, 256 subjects screened in phase 1, 1,124 (89.6%) were included in the study. Also, 161 cases with suspected symptoms of RLS were detected in phase 1, 49 of the suspected cases could not be evaluated in phase 2. A diagnosis of RLS was also made in 60 cases during phase 2. We defined the prevalence of RLS as 9.71% among 40 years of age and older population. The prevalence of RLS did not differ by age and was 2.6 times more in women. None of the patients were diagnosed as RLS sought medical care for the symptoms, possibly due to lack of knowledge of patients and physicians about RLS. Prevalence studies help to provide knowledge on morbidity, which is essential for diagnosis and early treatment.

  3. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  4. Enabling the Discovery of Gravitational Radiation

    Science.gov (United States)

    Isaacson, Richard

    2017-01-01

    The discovery of gravitational radiation was announced with the publication of the results of a physics experiment involving over a thousand participants. This was preceded by a century of theoretical work, involving a similarly large group of physicists, mathematicians, and computer scientists. This huge effort was enabled by a substantial commitment of resources, both public and private, to develop the different strands of this complex research enterprise, and to build a community of scientists to carry it out. In the excitement following the discovery, the role of key enablers of this success has not always been adequately recognized in popular accounts. In this talk, I will try to call attention to a few of the key ingredients that proved crucial to enabling the successful discovery of gravitational waves, and the opening of a new field of science.

  5. 49 CFR 229.85 - Doors and cover plates marked “Danger”.

    Science.gov (United States)

    2010-10-01

    ... System § 229.85 Doors and cover plates marked “Danger”. All doors and cover plates guarding high voltage equipment shall be marked “Danger—High Voltage” or with the word “Danger” and the normal voltage carried...

  6. 77 FR 42016 - Product Change-Every Door Direct Mail-Retail

    Science.gov (United States)

    2012-07-17

    ... Change--Every Door Direct Mail--Retail AGENCY: Postal Service\\TM\\. ACTION: Notice. SUMMARY: The Postal... Door Direct Mail--Retail to the market-dominant product list within the Mail Classification Schedule... Direct Mail--Retail to the Mail Classification Schedule, pursuant to 39 U.S.C. 3642. Documents...

  7. Reducing door to needle time for stroke thrombolysis.

    Science.gov (United States)

    Gill, Sumanjit

    2014-01-01

    Better outcomes are obtained with stroke thrombolysis the more rapidly it is given, both in terms of the patient's level of functional ability and also mortality. Current UK performance targets (outside London) aim for a time of 45 minutes or less. Thrombolysis pathways involve multidisciplinary working across departmental boundaries as well as senior level decision making. Our system used telemedicine out of hours adding additional complexity to the pathway. The initial planning stages started by auditing current practice and mapping the existing pathway. The figures for door to needle times were held on a database on the stroke unit and collected in detail for the purposes of national reporting. The pathway was mapped by combining personal experience of working within the stroke service with the experiences of the general medical registrars who worked the system out of hours. The initial action was to present this information throughout the hospital at departmental meetings. Opinions were canvassed at these meetings on where the biggest barriers were within the pathway and how we could address them. An awareness campaign was held by advertising over the intranet. An intervention comprising the following elements was introduced over the period of a year: introduction of an ambulance pre-alert, revision of the existing pathway, and education to all those involved in thrombolysis. The cases where particularly long delays were noted were audited in more depth to identify barriers to flow through the system. This was reported in ward meetings for staff to contribute experience and to offer solutions. We went to commissioning group meetings to gain the support of the local ambulance service, and talked to A&E seniors about the project and the ways in which they could help. Median times were calculated from a stroke database. There was a fall in median door to needle time of 65.5 to 49 minutes over a period of 18 months. A complex intervention to improve door to needle

  8. Discovery and Innovation: Submissions

    African Journals Online (AJOL)

    Discovery and Innovation publishes articles and reports in a wide range of ... with the social sciences, particularly as they relate to major areas of concern in Africa. ... The article should begin with an Introduction, stating the hypothesis, defining ...

  9. The art of discovery

    Directory of Open Access Journals (Sweden)

    Susie J. Lee

    2009-06-01

    Full Text Available "The Art of Discovery" discusses an ambitious educational program taught by the artist which incorporated locative media, contemporary art, site specificity, and creative work as a proposal for the integration of art, technology and science.

  10. The Learning Discovery

    Science.gov (United States)

    Prout, Joan

    1975-01-01

    The learning discovery of youngsters is a do-it-yourself teaching method for clerical, administrative, and accountant trainees at the Bankside House headquarters of the Central Electricity Generating Board's South Eastern Region, London. (Author)

  11. Leadership and Discovery

    CERN Document Server

    Goethals, George R

    2009-01-01

    This book, a collection of essays from scholars across disciplines, explores leadership of discovery, probing the guided and collaborative exploration and interpretation of the experience of our inner thoughts and feelings, and of our external worlds

  12. Discovery and Innovation

    African Journals Online (AJOL)

    Discovery and Innovation is a journal of the African Academy of Sciences (AAS) and ... World, emphasizing the progress in scientific research and issues that impinge on these two areas as well as circumscribe science-driven development.

  13. Platforms for antibiotic discovery.

    Science.gov (United States)

    Lewis, Kim

    2013-05-01

    The spread of resistant bacteria, leading to untreatable infections, is a major public health threat but the pace of antibiotic discovery to combat these pathogens has slowed down. Most antibiotics were originally isolated by screening soil-derived actinomycetes during the golden era of antibiotic discovery in the 1940s to 1960s. However, diminishing returns from this discovery platform led to its collapse, and efforts to create a new platform based on target-focused screening of large libraries of synthetic compounds failed, in part owing to the lack of penetration of such compounds through the bacterial envelope. This article considers strategies to re-establish viable platforms for antibiotic discovery. These include investigating untapped natural product sources such as uncultured bacteria, establishing rules of compound penetration to enable the development of synthetic antibiotics, developing species-specific antibiotics and identifying prodrugs that have the potential to eradicate dormant persisters, which are often responsible for hard-to-treat infections.

  14. Antibiotic drug discovery.

    Science.gov (United States)

    Wohlleben, Wolfgang; Mast, Yvonne; Stegmann, Evi; Ziemert, Nadine

    2016-09-01

    Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

  15. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  16. Discovery Driven Growth

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2009-01-01

    Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

  17. Chemoinformatics and Drug Discovery

    Directory of Open Access Journals (Sweden)

    Arnold Hagler

    2002-08-01

    Full Text Available This article reviews current achievements in the field of chemoinformatics and their impact on modern drug discovery processes. The main data mining approaches used in cheminformatics, such as descriptor computations, structural similarity matrices, and classification algorithms, are outlined. The applications of cheminformatics in drug discovery, such as compound selection, virtual library generation, virtual high throughput screening, HTS data mining, and in silico ADMET are discussed. At the conclusion, future directions of chemoinformatics are suggested.

  18. Simulation of the noise transmission through automotive door seals

    CERN Document Server

    Hazir, Andreas

    2016-01-01

    Andreas Hazir is investigating the door seal contribution to the interior noise level of production vehicles. These investigations contain experimental contribution analyses of real production vehicles and of academic test cases as well as the development of a simulation methodology for noise transmission through sealing systems and side windows. The simulations are realized by coupling transient computational aeroacoustics of the exterior flow to nonlinear finite element simulations of the structural transmission. By introducing a linear transmission model, the setup and computational costs of the seal noise transmission are significantly reduced, resulting in the feasibility of numerical contribution analyses of real production vehicles. Contents Contribution Analyses of Production Vehicles Acoustic Excitation versus Aeroacoustic Excitation Development of a Simulation Methodology Sensitivity Analysis of Noise Transmission Simulations Target Groups Researchers and students in the field of automotive engineer...

  19. Windows to the world, doors to the space

    DEFF Research Database (Denmark)

    Vogler, A.; Jørgensen, Jesper

    2005-01-01

    functionality with mental representation and symbolic meaning. Space-connection interfaces such as doors and windows act as “sensory organs” of a building. They allow inside-out communication, but also allow the user to control the flow of light and air, which in a direct or indirect way are communication......Living in a confined environment with minimal external stimuli available, such as a space habitat, is a strain on normal human life and puts great pressure on groups and individuals. Designers working on a space habitat not only must work on its functional role, but also must integrate...... mediums. In this paper the authors advocate a closer connection among architecture, anthropology and psychology in designing space habitats as part of a new concept of environmental design strategy in space architecture....

  20. Bluetooth enables in-door mobile location services

    DEFF Research Database (Denmark)

    Thongthammachart, Saowanee; Olesen, Henning

    2003-01-01

    Several technologies can be applied to enable mobile location services, but most of them suffer from limited accuracy and availability. GPS can solve the problem of determining the location of users in most outdoor situations, but an end-user position inside a building cannot be pinpointed. Other...... mobile location techniques can also provide the user's position, but the accuracy is rather low. In order to improve the accuracy and make location-based services really attractive, existing approaches must be supplemented by new technologies. Wireless short-range technologies like Bluetooth could...... be candidates for solving these problems. This paper shows that Bluetooth can act as a key enabler of mobile location services in an in-door environment. The advantage of Bluetooth technology is, that it can provide rather precise location data inside a building or hotspot area, while the Bluetooth terminal...

  1. Metadata-Centric Discovery Service

    Science.gov (United States)

    Huang, T.; Chung, N. T.; Gangl, M. E.; Armstrong, E. M.

    2011-12-01

    It is data about data. It is the information describing a picture without looking at the picture. Through the years, the Earth Science community seeks better methods to describe science artifacts to improve the quality and efficiency in information exchange. One the purposes are to provide information to the users to guide them into identifies the science artifacts of their interest. The NASA Distributed Active Archive Centers (DAACs) are the building blocks of a data centric federation, designed for processing and archiving from NASA's Earth Observation missions and their distribution as well as provision of specialized services to users. The Physical Oceanography Distributed Active Archive Center (PO.DAAC), at the Jet Propulsion Laboratory, archives and distributes science artifacts pertain to the physical state of the ocean. As part of its high-performance operational Data Management and Archive System (DMAS) is a fast data discovery RESTful web service called the Oceanographic Common Search Interface (OCSI). The web service searches and delivers metadata on all data holdings within PO.DAAC. Currently OCSI supports metadata standards such as ISO-19115, OpenSearch, GCMD, and FGDC, with new metadata standards still being added. While we continue to seek the silver bullet in metadata standard, the Earth Science community is in fact consists of various standards due to the specific needs of its users and systems. This presentation focuses on the architecture behind OCSI as a reference implementation on building a metadata-centric discovery service.

  2. Telling About Southern Fluctuations: Elizabeth Spencer at the Back Door

    Directory of Open Access Journals (Sweden)

    Gérald PRÉHER

    2011-06-01

    Full Text Available Le troisième roman d’Elizabeth Spencer, The Voice at the Back Door (1956, appartient à son cycle du Mississippi. Il traite des relations raciales et de la violence sudiste, deux thèmes qui n’avaient pas bonne presse à cette époque puisque le mouvement pour les droits civiques débutait. Le roman rappelle L’intrus (1948 de Faulkner en ce qu’il met en scène la recherche du coupable du meurtre d’un homme blanc. Cet article analyse la façon dont Spencer dépeint les manières du Sud en s’interrogeant sur les relations raciales. Le roman est également lu dans le contexte de sa publication puisque Spencer fut perçue comme une traîtresse par les Sudistes. Spencer utilise des sujets impopulaires pour révéler le paradoxe au cœur de la manière de vivre sudiste et montre combien le passé se rejoue constamment dans le présent.Elizabeth Spencer’s third novel, The Voice at the Back Door (1956, is part of her Mississippi cycle. It deals with race relations and southern violence, two highly controversial issues at the time since the Civil Rights Movements were beginning. The novel, reminiscent of William Faulkner’s Intruder in the Dust (1948, stages the search for a culprit after the murder of a white man. This paper focuses on Spencer’s portrait of southern manners and interracial relationships and analyzes the novel in the context of its publication. It will show that Spencer uses unpopular topics to expose the paradox at the core of the southern way of life and show that the past is constantly reenacted in the present.

  3. Open access

    NARCIS (Netherlands)

    Valkenburg, P.M.

    2015-01-01

    Open access week Van 19 tot en met 25 oktober 2015 vond wereldwijd de Open Access Week plaats. Tijdens deze week werden er over de hele wereld evenementen georganiseerd waar open access een rol speelt. Ook in Nederland zijn er diverse symposia, workshops en debatten georganiseerd zoals het debat in

  4. Energy and Charge Transfer in Open Plasmonic Systems

    Science.gov (United States)

    Thakkar, Niket

    Coherent and collective charge oscillations in metal nanoparticles (MNPs), known as localized surface plasmons, offer unprecedented control and enhancement of optical processes on the nanoscale. Since their discovery in the 1950's, plasmons have played an important role in understanding fundamental properties of solid state matter and have been used for a variety of applications, from single molecule spectroscopy to directed radiation therapy for cancer treatment. More recently, experiments have demonstrated quantum interference between optically excited plasmonic materials, opening the door for plasmonic applications in quantum information and making the study of the basic quantum mechanical properties of plasmonic structures an important research topic. This text describes a quantitatively accurate, versatile model of MNP optics that incorporates MNP geometry, local environment, and effects due to the quantum properties of conduction electrons and radiation. We build the theory from first principles, starting with a silver sphere in isolation and working our way up to complex, interacting plasmonic systems with multiple MNPs and other optical resonators. We use mathematical methods from statistical physics and quantum optics in collaboration with experimentalists to reconcile long-standing discrepancies amongst experiments probing plasmons in the quantum size regime, to develop and model a novel single-particle absorption spectroscopy, to predict radiative interference effects in entangled plasmonic aggregates, and to demonstrate the existence of plasmons in photo-doped semiconductor nanocrystals. These examples show more broadly that the theory presented is easily integrated with numerical simulations of electromagnetic scattering and that plasmonics is an interesting test-bed for approximate methods associated with multiscale systems.

  5. Door-to-door survey of major neurological disorders (project in Al Quseir City, Red Sea Governorate, Egypt

    Directory of Open Access Journals (Sweden)

    El Tallawy HN

    2013-05-01

    Full Text Available Hamdy NA El Tallawy,1 Wafaa MA Farghaly,1 Tarek A Rageh,1 Ghaydaa A Shehata,1 Reda Badry,1 Nabil A Metwally,2 Esam A El Moselhy,2 Mahmoud Hassan,2 Mohamed A Sayed,3 Ahmed A Waris,1 Yaser Hamed,2 Islam Shaaban,2 Mohamed A Hamed,1 Mahmoud Raafat Kandil11Department of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Neurology and Public Health, Faculty of Medicine, Al-Azhar University (Assiut branch, Assiut, Egypt; 3Department of Neurology, Faculty of Medicine, Sohag University, Sohag, EgyptAbstract: A door-to-door survey, including every household, was conducted for all inhabitants of Al Quseir City (33,283, Red Sea Governorate, Egypt by three specialists of neurology as well as nine senior staff members of neurology and 15 female social workers to assess the epidemiology of major neurological disorders. Over six phases, from July 1, 2009 to January 31, 2012, screening of all eligible people in the population was carried out, by which case ascertainment of all major neurological disorders included in the study was done according to the accepted definitions and diagnostic criteria of the World Health Organization. The order of frequency of prevalence of the studied neurological disorders was dementia (3.83% for those aged > 60 years, migraine (2.8% for those aged > 8 years, stroke (6.2/1000 for those aged > 20 years, epilepsy (5.5/1000, Parkinson’s disease (452.1/100,000 for those aged > 40 years, cerebral palsy (3.6/1000 among children 37 years, chorea (21.03/100,000, athetosis (15/100,000, and multiple sclerosis (13.74/100,000. The incidence rates of stroke, epilepsy, and Bell’s palsy were 181/100,000, 48/100,000, and 98.9/100,000 per year, respectively.Keywords: prevalence, incidence, neurological disorders

  6. Prevalence of epilepsy, beliefs and attitudes in a rural community in Mexico: A door-to-door survey.

    Science.gov (United States)

    San-Juan, Daniel; Alvarado-León, Susana; Barraza-Díaz, Jorge; Davila-Avila, Ned Merari; Ruíz, Axel Hernandez; Anschel, David J

    2015-05-01

    The study aimed to establish the prevalence of seizure history (SH) and epilepsy in a rural community in Hidalgo, Mexico and determine the patients' beliefs and attitudes towards the disease and its initial medical treatment. A transverse, descriptive, door-to-door epidemiological study (April 2011-November 2012) was conducted with 863 inhabitants from Xocotitla, Huejutla, Hidalgo, Mexico (162 housing units). Patients with SH were identified with an adaptation of the WHO protocol for epidemiological studies of neurological diseases. Afterwards, the subjects identified with seizure history (SH) or epilepsy were interviewed with a 20-question Likert type questionnaire regarding the management and belief set of their SH. The interviews were conducted in Spanish and Nahuatl. The prevalence of epilepsy and isolated nonrecurring seizures was 38.2/1000 and 25.4/1000, respectively. Out of the total population of 863 inhabitants, 33/863 were identified with SH: only 39.3% were able to identify an epileptic seizure as such, 48.5% sought medical attention upon the first seizure, 33.3% used a traditional healer, 15.2% took no action, 3% sought a religious representative, 85% lacked any lab analysis, and 60% received no antiepileptic drugs. Only 39% received free local medical attention, 69.7% considered seizures and epilepsy to be a consequence of divine intervention, and 94% reported some type of discrimination. A high prevalence of epilepsy and SH was found in this rural community in Mexico. Divine/religious beliefs, discrimination, scarce access to basic health services and inadequate medical management of epilepsy and SH persist. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. LITERATURE FORENSICS? DOOR TO WHAT WAS KNOWN BUT NOW FORGOTTEN

    Science.gov (United States)

    Science's all-consuming drive to make new discoveries often risks losing sight of what was already known at one time - that which already exists in the published literature. Inadequate attention to the published literature and insufficient time devoted to its mining and synthesis...

  8. `Shut The Front Door!':. Obviating the Challenge of Large-Scale Extra Dimensions and Psychophysical Bridging

    Science.gov (United States)

    Amoroso, Richard L.

    2013-09-01

    Physics has been slowly and reluctantly beginning to address the role and fundamental basis of the `observer' which has until now also been considered metaphysical and beyond the mandate of empirical rigor. It is suggested that the fundamental premise of the currently dominant view of `Cognitive Theory' - "Mind Equals Brain" is erroneous; and the associated belief that the `Planck scale, `the so-called basement level of reality', as an appropriate arena from which to model psycho-physical bridging is also in error. In this paper we delineate a simple, inexpensive experimental design to `crack the so-called cosmic egg' thereby opening the door to largescale extra dimensions (LSXD) tantamount to the regime of the unified field and thus awareness. The methodology surmounts the quantum uncertainty principle in a manner violating Quantum Electrodynamics, (QED), a cornerstone of modern theoretical physics, by spectrographic analysis of newly theorized Tight-Bound State (TBS) Bohr orbits in `continuous-state' transition frequencies of atomic hydrogen. If one wonders why QED violation in the spectra of atomic hydrogen relates to solving the mind-body (observer) problem; consider this a 1st wrench in a forthcoming tool box of Unified Field Mechanics, UF that will soon enough in retrospect cause the current tools of Classical and Quantum Mechanics to appear as stone axes. Max Planck is credited as the founder of quantum mechanics with his 1900 quantum hypothesis that energy is radiated and absorbed discretely by the formulation, E = hv. Empirically implementing this next paradigm shift utilizing parameters of the long sought associated `new physics' of the 3rd regime (classicalquantum- unified) allows access to LSXD of space; thus pragmatically opening the domain of mental action for the 1st time in history. This rendering constitutes a massive paradigm shift to Unified Field Theory creating a challenge for both the writer and the reader!

  9. Discussion on Non-necessity for Electrical Monitoring of Normal-closed Fire Doors in Places without Intensive Personnel%非人员密集场所常闭防火门无需电气监控探讨

    Institute of Scientific and Technical Information of China (English)

    李蔚; 冯晓良; 冯涛; 陈车; 蔡雄飞

    2016-01-01

    从防火门的相关概念与业内共识入手,通过对中国和美国多个与电气消防相关规范的剖析,并结合工程实例进行分析,本着“技术可靠性、经济合理性协调统一”的设计原则与理念,得出结论如下:对每个常开防火门必须实施电气监控,而对于常闭防火门仅需监控人员密集场所中因管理需要平时常闭的疏散门及具有信号反馈功能的防火门。对住宅、办公等非人员密集场所平时常闭的疏散防火门,无需电气监控。%This article starts with relevant concepts of fire door and industry consensus, and analyzes relevant specifications on electrical firefighting in China and the US, as well as actual projects. Holding the design principle of “coordination between technical reliability and economic rationality”, and combing the foresaid analyses, the author concludes that electrical monitoring should be implemented for each normal-open fire door; normal-closed fire doors that should be provided with electrical monitoring are evacuation doors that are normally closed due to management needs in personnel intensive places and doors that provides signal feedback function; there is no need for electrical monitoring for normal-closed fire doors in places like residential and office buildings without intensive personnel.

  10. A Field Survey of Window-Opening Behavior and Thermal Conditions in Apartments of Surabaya, Indonesia

    OpenAIRE

    Arethusa, Meita Tristida; Kubota, Tetsu; Nugroho, Agung Murti; Antaryama, I Gusti Ngurah; Ekasiwi, Sri Nastiti; Uno, Tomoko

    2014-01-01

    A field survey was conducted in apartments of Surabaya, Indonesia to investigate occupants’ window-opening behavior and their thermal conditions. A total of 347 households were interviewed and about 30 houses were covered for measurements of thermal conditions. It was seen that occupants in the naturally ventilated apartments tend to open windows or doors as much as possible at least during daytime for satisfying air flow and ventilation in particular. The average duration of opening windows/...

  11. How to Nurture Scientific Discoveries Despite Their Unpredictable Nature

    CERN Document Server

    Loeb, Abraham

    2012-01-01

    The history of science reveals that major discoveries are not predictable. Naively, one might conclude therefore that it is not possible to artificially cultivate an environment that promotes discoveries. I suggest instead that open research without a programmatic agenda establishes a fertile ground for unexpected breakthroughs. Contrary to current practice, funding agencies should allocate a small fraction of their funds to support research in centers of excellence without programmatic reins tied to specific goals.

  12. Open Day at the World Trade Organization

    CERN Multimedia

    2009-01-01

    On Sunday 6 September, the World Trade Organization will open its doors to the public. Throughout the day there will be guided tours of the building, which will reveal the many works of art donated by countries over the years; on the main terrace, food stands will give visitors a flavour of the worldwide membership of the WTO and provide the opportunity to sample regional specialities; and children can have fun with face painting, a bouncy castle and a drawing contest on the theme "Draw me globalization" and/or "Draw me the WTO". The full programme of activities

  13. Open hardware for open science

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Inspired by the open source software movement, the Open Hardware Repository was created to enable hardware developers to share the results of their R&D activities. The recently published CERN Open Hardware Licence offers the legal framework to support this knowledge and technology exchange.   Two years ago, a group of electronics designers led by Javier Serrano, a CERN engineer, working in experimental physics laboratories created the Open Hardware Repository (OHR). This project was initiated in order to facilitate the exchange of hardware designs across the community in line with the ideals of “open science”. The main objectives include avoiding duplication of effort by sharing results across different teams that might be working on the same need. “For hardware developers, the advantages of open hardware are numerous. For example, it is a great learning tool for technologies some developers would not otherwise master, and it avoids unnecessary work if someone ha...

  14. Archaeological Discoveries in Liaoning

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    LIAONING Province, in northeastern China, has been inhabited by many ethnic groups since ancient times. It is one of the sites of China’s earliest civilization. Since the 1950s many archaeological discoveries from periods beginning with the Paleolithic of 200,000 years ago, and through all the following historic periods, have been made in the province.

  15. Discovery of TUG-770

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth; Hansen, Steffen V F; Urban, Christian;

    2013-01-01

    Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical a...

  16. Ayurvedic drug discovery.

    Science.gov (United States)

    Balachandran, Premalatha; Govindarajan, Rajgopal

    2007-12-01

    Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested evidences vouch immense therapeutic benefits for ayurvedic herbs and formulations, several important issues are required to be resolved for successful implementation of ayurvedic principles to present drug discovery methodologies. Additionally, clinical examination in the extent of efficacy, safety and drug interactions of newly developed ayurvedic drugs and formulations are required to be carefully evaluated. Ayurvedic experts suggest a reverse-pharmacology approach focusing on the potential targets for which ayurvedic herbs and herbal products could bring tremendous leads to ayurvedic drug discovery. Although several novel leads and drug molecules have already been discovered from ayurvedic medicinal herbs, further scientific explorations in this arena along with customization of present technologies to ayurvedic drug manufacturing principles would greatly facilitate a standardized ayurvedic drug discovery.

  17. The Scholarship of Discovery.

    Science.gov (United States)

    Dobos, Jean

    2000-01-01

    Contributes to a special issue on how the reconsideration of what scholarship is affects the way in which scholarship is assessed. Examines traditional criteria for evaluating faculty research. Identifies activities pertinent to the scholarship of discovery, and the assessment practices in the field of communication as well as in general use. (SR)

  18. Discovery Education: A Definition.

    Science.gov (United States)

    Wilson, Harold C.

    2002-01-01

    Discovery Education is based on the writings of Henry David Thoreau, an early champion of experiential learning. After 2 months of preparation, 10th-grade students spent 4 days in the wilderness reenacting a piece of history, such as the Lewis and Clark Expedition. The interdisciplinary approach always included journal-writing. Students gained…

  19. Discovery through Gossip

    CERN Document Server

    Haeupler, Bernhard; Peleg, David; Rajaraman, Rajmohan; Sun, Zhifeng

    2012-01-01

    We study randomized gossip-based processes in dynamic networks that are motivated by discovery processes in large-scale distributed networks like peer-to-peer or social networks. A well-studied problem in peer-to-peer networks is the resource discovery problem. There, the goal for nodes (hosts with IP addresses) is to discover the IP addresses of all other hosts. In social networks, nodes (people) discover new nodes through exchanging contacts with their neighbors (friends). In both cases the discovery of new nodes changes the underlying network - new edges are added to the network - and the process continues in the changed network. Rigorously analyzing such dynamic (stochastic) processes with a continuously self-changing topology remains a challenging problem with obvious applications. This paper studies and analyzes two natural gossip-based discovery processes. In the push process, each node repeatedly chooses two random neighbors and puts them in contact (i.e., "pushes" their mutual information to each oth...

  20. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  1. Open Access

    Science.gov (United States)

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder…

  2. Platform Screen Doors Enhanced Bus Rapid Transit Intelligent Performance

    Directory of Open Access Journals (Sweden)

    Chonghua Zhou

    2011-06-01

    Full Text Available It is the last straw to clutch at to solve the urban traffic issue, to develop high-capacity rapid transit and promote transit priority. Characterized by low cost, short construction cycle and flexible development, Bus Rapid Transit (BRT has been favored by more and more cities in the world. The Platform Screen Doors (PSDs system is an important component at BRT stations, and it is original motive to be designed to satisfy the growing demand from BRT application to provide increased safety and comfort in the first. With the continual increased demand for BRT intelligent performance, the PSDs system is applied to get Bus Location Information with accurate position of arrival and departure at stop, to provide Real-Time Information (RTI for BRT passengers using PSDs/GPS compound location technology, to put into practice Bus Fleet Management (BFM. Considering the capability of accurate location, it can be applied to actualize Bus Sign Priority in the future. The authors are luck to take in part the practice of BRT system, especially in the BRT intelligent systems, the papers will introduce upwards application and conceive in detail.

  3. The Vaccination of 35,000 Dogs in 20 Working Days Using Combined Static Point and Door-to-Door Methods in Blantyre, Malawi.

    Directory of Open Access Journals (Sweden)

    Andrew D Gibson

    2016-07-01

    Full Text Available An estimated 60,000 people die of rabies annually. The vast majority of cases of human rabies develop following a bite from an infected dog. Rabies can be controlled in both human and canine populations through widespread vaccination of dogs. Rabies is particularly problematic in Malawi, costing the country an estimated 13 million USD and 484 human deaths annually, with an increasing paediatric incidence in Blantyre City. Consequently, the aim of this study was to vaccinate a minimum of 75% of all the dogs within Blantyre city during a one month period. Blantyre's 25 administrative wards were divided into 204 working zones. For initial planning, a mean human:dog ratio from the literature enabled estimation of dog population size and dog surveys were then performed in 29 working zones in order to assess dog distribution by land type. Vaccination was conducted at static point stations at weekends, at a total of 44 sites, with each operating for an average of 1.3 days. On Monday to Wednesday, door-to-door vaccination sessions were undertaken in the areas surrounding the preceding static point stations. 23,442 dogs were vaccinated at static point stations and 11,774 dogs were vaccinated during door-to-door vaccinations. At the end of the 20 day vaccination programme, an assessment of vaccination coverage through door-to-door surveys found that of 10,919 dogs observed, 8,661 were vaccinated resulting in a vaccination coverage of 79.3% (95%CI 78.6-80.1%. The estimated human:dog ratio for Blantyre city was 18.1:1. Mobile technology facilitated the collection of data as well as efficient direction and coordination of vaccination teams in near real time. This study demonstrates the feasibility of vaccinating large numbers of dogs at a high vaccination coverage, over a short time period in a large African city.

  4. Registratie van voedselinfecties en -vergiftigingen onderzocht door GGD's en Keuringsdiensten van waren, 1999

    NARCIS (Netherlands)

    van Duynhoven YTHP; de Wit MAS; CIE

    2000-01-01

    In deze rapportage worden de gegevens gepresenteerd van voedselinfecties en voedselvergiftigingen in Nederland in 1999. De resultaten zijn gebaseerd op meldingen door consumenten aan de Keuringsdienst van Waren, op standaard rapportages van onderzochte explosies van voedselinfecties en -vergiftigin

  5. Kwaliteitsverbetering binnen het laboratorium door middel van de GLP regels en kwaliteitsborging

    NARCIS (Netherlands)

    Strik; J.J.T.W.A.

    1987-01-01

    Het besef groeit dat waarborging van kwaliteit de centrale doelstelling dient te zijn bij de produktie van goederen en diensten. Dit leidt ertoe dat de kwaliteitsbewaking wordt omgebogen naar procesbeheersing. Dit wordt binnen het gezondheidsonderzoek en milieuhygiene begeleid door richtlijnen,

  6. An intelligent automated door control system based on a smart camera

    National Research Council Canada - National Science Library

    Yang, Jie-Ci; Lai, Chin-Lun; Sheu, Hsin-Teng; Chen, Jiann-Jone

    2013-01-01

    This paper presents an innovative access control system, based on human detection and path analysis, to reduce false automatic door system actions while increasing the added values for security applications...

  7. Methaanuitstoot spiegel van rantsoen : lager eiwitgehalte in gras door huidig mestbeleid geeft meer methaanuitstoot

    NARCIS (Netherlands)

    Bannink, A.; Dijkstra, J.

    2012-01-01

    De uitstoot van methaangas door een koe is een afspiegeling van haar voedselvertering. Wageningen UR onderzoekt het effect van rantsoenaanpassingen. Het levert een aantal concrete handvatten voor het terugdringen van de methaanuitstoot.

  8. Methaanuitstoot spiegel van rantsoen : lager eiwitgehalte in gras door huidig mestbeleid geeft meer methaanuitstoot

    NARCIS (Netherlands)

    Bannink, A.; Dijkstra, J.

    2012-01-01

    De uitstoot van methaangas door een koe is een afspiegeling van haar voedselvertering. Wageningen UR onderzoekt het effect van rantsoenaanpassingen. Het levert een aantal concrete handvatten voor het terugdringen van de methaanuitstoot.

  9. Beter Leren van Hypertext door Aandachtsturing binnen Grafische Overzichten - een Eye Tracking Onderzoek

    NARCIS (Netherlands)

    Bezdan, Eniko; Kester, Liesbeth; Kirschner, Paul A.

    2011-01-01

    Bezdan, E., Kester, L., & Kirschner, P. A. (2011, 9 Juni). Beter Leren van Hypertext door Aandachtsturing binnen Grafische Overzichten - een Eye Tracking Onderzoek. Poster gepresenteerd tijdens de Onderwijs Research Dagen, Maastricht, Nederland.

  10. A Review on Quantitative Approaches for Dock Door Assignment in Cross-Docking

    Directory of Open Access Journals (Sweden)

    Adibah Shuib

    2012-01-01

    Full Text Available Cross docking is a relatively new technique in supply chain operations. It offers limited storage time to maximize the efficiency of goods transshipment. Efficient operation of a cross docking system requires an appropriate coordination of inbound and outbound flows, accurate planning and dynamic scheduling.  The planning strategies at cross docking terminals, which are receiving growing attention today, are the truck-to-door assignment and destination to door assignment problems. This paper provides a comprehensive literature review of quantitative approaches in dock door assignment problems of cross docking planning. The contributions of this paper are to identify the gap of knowledge in operational levels mainly in dock door assignment and to point out the future research direction in cross docking.

  11. Development of Experimental Device for Compression Load Deflection of Car Door Seals

    Institute of Scientific and Technical Information of China (English)

    赵建才; 朱训生; 万德安

    2003-01-01

    A new experimental device has been developed for analyzing compression load deflection of the door seal by using stereovision theory. Precision instruments of optical grating and force sensor are also integrated in this device. Force-displacement response characteristics of compression at varied speed can be controlled. Solid foundations for characteristic and structure as well as optimization design of the car door seal are elucidated.

  12. Open Source and Open Standards

    NARCIS (Netherlands)

    Koper, Rob

    2006-01-01

    Publication reference: Koper, R. (2008). Open Source and Open Standards. In J. M. Spector, M. Merrill, J. van Merriënboer & M. P. Driscol (Eds.), Handbook of Research on Educational Communications and Technology (3rd ed., pp. 355-368). New York: Routledge.

  13. How does the effort spent to hold a door affect verbal thanks and reciprocal help?

    Directory of Open Access Journals (Sweden)

    Glenn Ryan Fox

    2015-11-01

    Full Text Available When someone holds a door for us we often respond with a verbal ``thanks.'' But given such a trivial favor, our feelings can vary considerably depending on how the door is held. Studies have shown that verbal thanking increases in relation to door-holding effort. However, it is unclear how such a favor can lead to verbal thanks in addition to reciprocal help. We examined how holding a door in an effortful or non-effortful manner relates to verbal thanking and reciprocal helping. We measured: (1 whether participants verbally thanked the experimenter, (2 whether they agreed to help another person by taking a survey, and (3 whether they helped pick up objects (pens that the door-holder subsequently dropped. Participants in the effortful condition were more likely to offer verbal thanks, to help pick up the pens, and to walk a greater distance to pick them up. Participants who thanked the door-holder, however, were not more likely to provide help.

  14. How Does the Effort Spent to Hold a Door Affect Verbal Thanks and Reciprocal Help?

    Science.gov (United States)

    Fox, Glenn R.; Araujo, Helder Filipe; Metke, Michael J.; Shafer, Chris; Damasio, Antonio

    2015-01-01

    When someone holds a door for us we often respond with a verbal “thanks.” But given such a trivial favor, our feelings can vary considerably depending on how the door is held. Studies have shown that verbal thanking increases in relation to door-holding effort. However, it is unclear how such a favor can lead to verbal thanks in addition to reciprocal help. We examined how holding a door in an effortful or non-effortful manner relates to verbal thanking and reciprocal helping. We measured: (1) whether participants verbally thanked the experimenter, (2) whether they agreed to help another person by taking a survey, and (3) whether they helped pick up objects (pens) that the door-holder subsequently dropped. Participants in the effortful condition were more likely to offer verbal thanks, to help pick up the pens, and to walk a greater distance to pick them up. Participants who thanked the door-holder, however, were not more likely to provide help. PMID:26617559

  15. Creating A Guided- discovery Lesson

    Institute of Scientific and Technical Information of China (English)

    田枫

    2005-01-01

    In a guided - discovery lesson, students sequentially uncover layers of mathematical information one step at a time and learn new mathematics. We have identified eight critical steps necessary in developing a successful guided- discovery lesson.

  16. Open IS

    DEFF Research Database (Denmark)

    Germonprez, Matt; Crowston, Kevin; Avital, Michel

    2013-01-01

    The collective intelligence and collective action of “open” communities have produced a variety of complex knowledge goods and radical social change. The Information Systems (IS) community has invested significant effort into researching open communities and the ecosystems in which they operate...... therefore seeks to stimulate a thoughtful and dynamic discussion around the proposition that becoming a more open community will enhance the IS discipline’s scholarly inquiry and global impact....

  17. Open IS

    DEFF Research Database (Denmark)

    Germonprez, Matt; Crowston, Kevin; Avital, Michel

    2013-01-01

    The collective intelligence and collective action of “open” communities have produced a variety of complex knowledge goods and radical social change. The Information Systems (IS) community has invested significant effort into researching open communities and the ecosystems in which they operate...... therefore seeks to stimulate a thoughtful and dynamic discussion around the proposition that becoming a more open community will enhance the IS discipline’s scholarly inquiry and global impact....

  18. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  19. Chronicles in drug discovery.

    Science.gov (United States)

    Davies, Shelley L; Moral, Maria Angels; Bozzo, Jordi

    2007-03-01

    Chronicles in Drug Discovery features special interest reports on advances in drug discovery. This month we highlight agents that target and deplete immunosuppressive regulatory T cells, which are produced by tumor cells to hinder innate immunity against, or chemotherapies targeting, tumor-associated antigens. Antiviral treatments for respiratory syncytial virus, a severe and prevalent infection in children, are limited due to their side effect profiles and cost. New strategies currently under clinical development include monoclonal antibodies, siRNAs, vaccines and oral small molecule inhibitors. Recent therapeutic lines for Huntington's disease include gene therapies that target the mutated human huntingtin gene or deliver neuroprotective growth factors and cellular transplantation in apoptotic regions of the brain. Finally, we highlight the antiinflammatory and antinociceptive properties of new compounds targeting the somatostatin receptor subtype sst4, which warrant further study for their potential application as clinical analgesics.

  20. The discovery of quarks.

    Science.gov (United States)

    Riordan, M

    1992-05-29

    Quarks are widely recognized today as being among the elementary particles of which matter is composed. The key evidence for their existence came from a series of inelastic electron-nucleon scattering experiments conducted between 1967 and 1973 at the Stanford Linear Accelerator Center. Other theoretical and experimental advances of the 1970s confirmed this discovery, leading to the present standard model of elementary particle physics.

  1. Discovery Systems for Manufacturing

    Science.gov (United States)

    1994-01-01

    the backbone of most of the materials discovery activities we pursue. We call the internal structure of a qualitative model an envisionment . A simple... envisionment (discussed in detail in the next chapter) from the polymer curing domain that is illustrated in figure 1-7. The initial conditions are...TSC "fires" IF-THEN rules which the initial conditions enable, building an envisonment. A stylized envisionment for the immunology knowledge base looks

  2. Opening van vier nieuwe laboratoria van de Afdeling der Werktuigbouwkunde van de Technische Hogeschool Delft

    NARCIS (Netherlands)

    Boon, E.F.; Boot, J.; Vahl, L.; Van Eldik Thieme, H.C.A.; Blok, H.

    1959-01-01

    Samenvatting van de toespraak door Prof.ir, R. van Hasselt bij de officiele opening van vier nieuwe laboratoriavan de Afdeling der Werktuigbouwkunde Boon, E.F. en Boot, J.: het Laboratorium voor Chemische Werktuigen Vahl, L.: het Laboratorium voor Koudetechniek Van Eldik Thieme, H.C.A.: het

  3. A transpersonal approach to care: a qualitative study of performers' experiences with DooR to DooR, a hospital-based arts program.

    Science.gov (United States)

    Hurdle, Caitlin E; Quinlan, Margaret M

    2014-06-01

    The arts have a history of relaxing and calming patients in the hospital setting, yet research is limited on how arts may aid in the healing process. DooR to DooR was established to bring comfort, respite, and healing to hospitalized patients, family members, and health care staff. DooR to DooR is located in the University of North Carolina Hospitals at Chapel Hill, North Carolina; professional performing artists visit there, spending 5 to 10 minutes with each patient, family member, and health care staff. The purpose of this qualitative study is to understand performers' experiences and of how arts-based programs can facilitate improved patient outcomes in the hospitalized setting to help nurses better use the arts in their care of patients and families. Three overarching themes were identified: (a) the arts are therapeutic for all involved, (b) the arts transform the hospital environment, and (c) nurses and the other medical staff play an important role. The significance of this study for nursing practice is that the arts are a plausible intervention for the hospital because they may help improve patient outcomes by reducing pain and depression and by relieving stress among staff and family members. More research is needed to determine the level of arts-as-an-intervention knowledge among nurses.

  4. Open access

    CERN Document Server

    Suber, Peter

    2012-01-01

    The Internet lets us share perfect copies of our work with a worldwide audience at virtually no cost. We take advantage of this revolutionary opportunity when we make our work "open access": digital, online, free of charge, and free of most copyright and licensing restrictions. Open access is made possible by the Internet and copyright-holder consent, and many authors, musicians, filmmakers, and other creators who depend on royalties are understandably unwilling to give their consent. But for 350 years, scholars have written peer-reviewed journal articles for impact, not for money, and are free to consent to open access without losing revenue. In this concise introduction, Peter Suber tells us what open access is and isn't, how it benefits authors and readers of research, how we pay for it, how it avoids copyright problems, how it has moved from the periphery to the mainstream, and what its future may hold. Distilling a decade of Suber's influential writing and thinking about open access, this is the indispe...

  5. Discovery Mondays: Zoom on materials

    CERN Multimedia

    2003-01-01

    Following the success of the first Discovery Monday, which had over 100 visitors, the series of evening events in Microcosm continues. On Monday 2nd June, discover the world of materials. Find out how CERN scientists examine, manufacture and study different materials, at different scales. Did you know for example that using electrons you can observe a hair at a scale equivalent to looking at a boat with the naked eye? Also, that using ultrasound, you can measure the thickness of an object that is completely inaccessible? Find out more about these techniques, and also the high-tech machining and soldering that is carried out in CERN's central workshop. Plus, see how engineers can detect tiny leaks through solder points - essential for maintaining the vacuum in the LHC. The evening is open to all, without reservation, suggested age 12 and above. Rendez-vous in Microcosm on Monday 2nd June From 19.30 - 21.00 Free entry For more information : http://www.cern.ch/microcosm Using a scanning microscope, the head o...

  6. Improving Data Discovery, Access, and Analysis to More Than Three Decades of Oceanographic and Geomorphologic Observations

    Science.gov (United States)

    Forte, M.; Hesser, T.; Knee, K.; Ingram, I.; Hathaway, K. K.; Brodie, K. L.; Spore, N.; Bird, A.; Fratantonio, R.; Dopsovic, R.; Keith, A.; Gadomski, K.

    2016-02-01

    The U.S. Army Engineer Research and Development Center's (USACE ERDC) Coastal and Hydraulics Laboratory (CHL) Coastal Observations and Analysis Branch (COAB) Measurements Program has a 35-year record of coastal observations. These datasets include oceanographic point source measurements, Real-Time Kinematic (RTK) GPS bathymetry surveys, and remote sensing data from both the Field Research Facility (FRF) in Duck, NC and from other project and experiment sites around the nation. The data has been used to support a variety of USACE mission areas, including coastal wave model development, beach and bar response, coastal project design, coastal storm surge, and other coastal hazard investigations. Furthermore these data have been widely used by a number of federal and state agencies, academic institutions, and private industries in hundreds of scientific and engineering investigations, publications, conference presentations and model advancement studies. A limiting factor to the use of FRF data has been rapid, reliable access and publicly available metadata for each data type. The addition of web tools, accessible data files, and well-documented metadata will open the door to much future collaboration. With the help of industry partner RPS ASA and the U.S. Army Corps of Engineers Mobile District Spatial Data Branch, a Data Integration Framework (DIF) was developed. The DIF represents a combination of processes, standards, people, and tools used to transform disconnected enterprise data into useful, easily accessible information for analysis and reporting. A front-end data portal connects the user to the framework that integrates both oceanographic observation and geomorphology measurements using a combination of ESRI and open-source technology while providing a seamless data discovery, access, and analysis experience to the user. The user interface was built with ESRI's JavaScript API and all project metadata is managed using Geoportal. The geomorphology data is made

  7. International Drug Discovery Science and Technology--BIT's Seventh Annual Congress.

    Science.gov (United States)

    Bodovitz, Steven

    2010-01-01

    BIT's Seventh Annual International Drug Discovery Science and Technology Congress, held in Shanghai, included topics covering new therapeutic and technological developments in the field of drug discovery. This conference report highlights selected presentations on open-access approaches to R&D, novel and multifactorial targets, and technologies that assist drug discovery. Investigational drugs discussed include the anticancer agents astuprotimut-r (GlaxoSmithKline plc) and AS-1411 (Antisoma plc).

  8. The 2015 Bioinformatics Open Source Conference (BOSC 2015.

    Directory of Open Access Journals (Sweden)

    Nomi L Harris

    2016-02-01

    Full Text Available The Bioinformatics Open Source Conference (BOSC is organized by the Open Bioinformatics Foundation (OBF, a nonprofit group dedicated to promoting the practice and philosophy of open source software development and open science within the biological research community. Since its inception in 2000, BOSC has provided bioinformatics developers with a forum for communicating the results of their latest efforts to the wider research community. BOSC offers a focused environment for developers and users to interact and share ideas about standards; software development practices; practical techniques for solving bioinformatics problems; and approaches that promote open science and sharing of data, results, and software. BOSC is run as a two-day special interest group (SIG before the annual Intelligent Systems in Molecular Biology (ISMB conference. BOSC 2015 took place in Dublin, Ireland, and was attended by over 125 people, about half of whom were first-time attendees. Session topics included "Data Science;" "Standards and Interoperability;" "Open Science and Reproducibility;" "Translational Bioinformatics;" "Visualization;" and "Bioinformatics Open Source Project Updates". In addition to two keynote talks and dozens of shorter talks chosen from submitted abstracts, BOSC 2015 included a panel, titled "Open Source, Open Door: Increasing Diversity in the Bioinformatics Open Source Community," that provided an opportunity for open discussion about ways to increase the diversity of participants in BOSC in particular, and in open source bioinformatics in general. The complete program of BOSC 2015 is available online at http://www.open-bio.org/wiki/BOSC_2015_Schedule.

  9. Open Brief

    Directory of Open Access Journals (Sweden)

    Andrew Leach

    2013-11-01

    Full Text Available To commence the thirtieth annual conference of the Society of Architectural Historians, Australia and New Zealand (SAHANZ, held on Australia’s Gold Coast in July 2013, ten delegates were invited with very little warning to take five minutes and one image to offer a provocation on the open matters of architectural history in the present moment. The term “open” was taken as the conference theme—a device used by SAHANZ meetings not so much to define the scope of papers presented as to declare the conference flavour year by year. It was not, therefore, an open conference (anything goes so much as a conference on open issues (where, indeed, to go.  The ten interlocutors were invited after the conference to document their interventions and they are presented here as a record of the preoccupations of a specific moment and institutional geography with all the idiosyncrasies and commonalities it might reveal to a broader audience.

  10. Prototyping service discovery and usage in wireless sensor networks

    NARCIS (Netherlands)

    Marin-Perianu, Raluca; Scholten, Hans; Havinga, Paul

    2007-01-01

    Heterogeneous Wireless Sensor Networks (WSNs) are envisioned to provide different types of services in an open and dynamic environment. This paper presents the design, implementation and evaluation of a service discovery and usage solution for heterogeneous WSNs. The users have the possibility to di

  11. A community-based approach to new antibiotic discovery.

    Science.gov (United States)

    Cooper, Matthew A

    2015-09-01

    The Community for Open Antimicrobial Drug Discovery aims to tap into the potential of the millions of compounds distributed around laboratories globally to be a source of new antibiotic leads by offering free screening for antimicrobial properties, with no strings attached.

  12. Prototyping Service Discovery and Usage in Wireless Sensor Networks

    NARCIS (Netherlands)

    Marin Perianu, Raluca; Scholten, Johan; Havinga, Paul J.M.

    2007-01-01

    Heterogeneous Wireless Sensor Networks (WSNs) are envisioned to provide different types of services in an open and dynamic environment. This paper presents the design, implementation and evaluation of a service discovery and usage solution for heterogeneous WSNs. The users have the possibility to

  13. The Discovery Channel Telescope

    Science.gov (United States)

    Millis, R. L.; Dunham, E. W.; Sebring, T. A.; Smith, B. W.; de Kock, M.; Wiecha, O.

    2004-11-01

    The Discovery Channel Telescope (DCT) is a 4.2-m telescope to be built at a new site near Happy Jack, Arizona. The DCT features a large prime focus mosaic CCD camera with a 2-degree-diameter field of view especially designed for surveys of KBOs, Centaurs, NEAs and other moving or time-variable targets. The telescope can be switched quickly to a Ritchey-Chretien configuration for optical/IR spectroscopy or near-IR imaging. This flexibility allows timely follow-up physical studies of high priority objects discovered in survey mode. The ULE (ultra-low-expansion) meniscus primary and secondary mirror blanks for the telescope are currently in fabrication by Corning Glass. Goodrich Aerospace, Vertex RSI, M3 Engineering and Technology Corp., and e2v Technologies have recently completed in-depth conceptual design studies of the optics, mount, enclosure, and mosaic focal plane, respectively. The results of these studies were subjected to a formal design review in July, 2004. Site testing at the 7760-ft altitude Happy Jack site began in 2001. Differential image motion observations from 117 nights since January 1, 2003 gave median seeing of 0.84 arcsec FWHM, and the average of the first quartile was 0.62 arcsec. The National Environmental Policy Act (NEPA) process for securing long-term access to this site on the Coconino National Forest is nearing completion and ground breaking is expected in the spring of 2005. The Discovery Channel Telescope is a project of the Lowell Observatory with major financial support from Discovery Communications, Inc. (DCI). DCI plans ongoing television programming featuring the construction of the telescope and the research ultimately undertaken with the DCT. An additional partner can be accommodated in the project. Interested parties should contact the lead author.

  14. Open Education and the Open Science Economy

    Science.gov (United States)

    Peters, Michael A.

    2009-01-01

    Openness as a complex code word for a variety of digital trends and movements has emerged as an alternative mode of "social production" based on the growing and overlapping complexities of open source, open access, open archiving, open publishing, and open science. This paper argues that the openness movement with its reinforcing structure of…

  15. Using heuristics to facilitate experiental learning in a simulation-based discovery learning environment

    NARCIS (Netherlands)

    Veermans, K.H.; Jong, de T.; Joolingen, van W.R.; Mason, L.; Andreuzza, S.; Arfè, B.; Favero, del L.

    2003-01-01

    Learners are often reported to experience difficulties with simulation-based discovery learning. Heuristics for discovery learning (rules of thumb that guide decision-making) can help learners to overcome these difficulties. In addition, the heuristics themselves are open for transfer. One way to in

  16. Influence of door handles design in effort perception: accessibility and usability.

    Science.gov (United States)

    Paschoarelli, Luis Carlos; Santos, Raquel; Bruno, Paula

    2012-01-01

    The application of ergonomics in product design is essential to its accessibility and usability. The development of manual devices should be based on ergonomic principles. Effort perception analysis is an essential approach to understand the physical and subjective aspects of the interface. The objective of the present study was to analyze the effort perception during a simulated task with different door handles by Portuguese subjects of both genders and different ages. This transversal study agreed with ethical aspects. 180 subjects of both genders pertaining to three age groups have participated. Five door handles with different shapes were evaluated. A subjective numeric rating scale of 5 levels was used to evaluate the effort. For statistical analysis it was applied the Friedman non-parametric test. The results have showed no significant differences of effort perception in door handles "A" and "B"; "A" and "D"; and "D" and "C". Door handle "E" presented the lowest values of all. In general, there's an inverse relationship between the results of biomechanical studies and the effort perception of the same task activity. This shows that door handles design influence directly these two variables and can interfere in the accessibility and usability of these kinds of products.

  17. The Open

    Directory of Open Access Journals (Sweden)

    Saitya Brata Das

    2009-12-01

    Full Text Available In the Open darkness and light, remembrance and oblivion, coming into existence and disappearing in death play their originary co-belonging, or co-figuration. Existence belongs to this opening and is exposed to its coming to presence: it is on the basis of this originary opening, this originary historical which is revealed to this mortal being called ‘man,’ on the basis of this revelation, man founds something like politics and history. There thus comes into existence out of this freedom, out of this “play space”2, this field called ‘polis’3 where there takes place war and festival, where historical revolutions tear apart history, brings ruptures and discontinuities in the very mode of his existence, where man seeks the foundation of his own foundation (which is his metaphysical task , where occurs the dialectics of negativity between man and man, where man puts at stake his own death, his own dissolution, and by the power of his own dissolution stands in relation to the total world that he seeks to dominate. This means that man’s attempts to metaphysically found his own political and historical existence must presuppose a far more originary non-foundation, the differentiating revealing of the open, the ungrounded spacing play, or playing space of natality and mortality.

  18. Open innovation

    DEFF Research Database (Denmark)

    West, Joel; Bogers, Marcel

    2017-01-01

    by small, new, and not-for-profit organizations, as well as the linkage of individual actions and motivations to open innovation. Other opportunities include better measuring the costs, benefits, antecedents, mediators and moderators of the effects of OI on performance, and understanding why and how OI...

  19. Barriers to and enablers for European rail freight transport for integrated door-to-door logistics service. Part 2: Enablers for multimodal rail freight transport

    Directory of Open Access Journals (Sweden)

    Dewan Md Zahurul ISLAM

    2014-12-01

    Full Text Available The objective of this paper is to examine and identify barriers to and enablers for the European rail freight transport services as a transport chain partner along the supply chains in the changing market scenario. The changing market scenario includes, among others, requiring 'door-to-door' rather than 'terminal to terminal' and integrated service, competitive ability to attract non-rail cargo type, changes in the customer requirements (e.g. reliable service and changes in the operational requirements and practices. Using a literature review method, the paper is presented in two parts. The part 1 focuses on the identification of barriers to the European rail freight service by reviewing freight logistics services for global supply chains followed by the current performance of European rail freight transport followed by a discussion on the rail freight market liberalisation in Europe. Then rail freight transport in the Unites States (U.S. is discussed. The research notes that although the background, scope and necessity for reform measures in Europe differ from those of the U.S., some lessons can be learned and the main lesson is that an appropriate reform measure can enhance rail sector competitive ability in Europe. The part 2 of the paper is dedicated to recommend some concrete steps and actions as enablers to remove the barriers identified in the part 1 to develop multimodal rail freight transport. The enablers for multimodal rail freight transport include: •\tEuropean rail freight transport market needs full liberalisation so that incumbent and new entrants can compete freely. •\tThe rail operators need to acquire service (e.g. customer tailored services, door to door service quality offered by road freight operators. •\tThey need to conduct a combination of ‘terminal-to-terminal’ and door-to-door operations, as and when needed; •\tThey must build partnership with freight forwarder or 3PLs to include all types of customers

  20. Causality discovery technology

    Science.gov (United States)

    Chen, M.; Ertl, T.; Jirotka, M.; Trefethen, A.; Schmidt, A.; Coecke, B.; Bañares-Alcántara, R.

    2012-11-01

    Causality is the fabric of our dynamic world. We all make frequent attempts to reason causation relationships of everyday events (e.g., what was the cause of my headache, or what has upset Alice?). We attempt to manage causality all the time through planning and scheduling. The greatest scientific discoveries are usually about causality (e.g., Newton found the cause for an apple to fall, and Darwin discovered natural selection). Meanwhile, we continue to seek a comprehensive understanding about the causes of numerous complex phenomena, such as social divisions, economic crisis, global warming, home-grown terrorism, etc. Humans analyse and reason causality based on observation, experimentation and acquired a priori knowledge. Today's technologies enable us to make observations and carry out experiments in an unprecedented scale that has created data mountains everywhere. Whereas there are exciting opportunities to discover new causation relationships, there are also unparalleled challenges to benefit from such data mountains. In this article, we present a case for developing a new piece of ICT, called Causality Discovery Technology. We reason about the necessity, feasibility and potential impact of such a technology.

  1. Automated Supernova Discovery (Abstract)

    Science.gov (United States)

    Post, R. S.

    2015-12-01

    (Abstract only) We are developing a system of robotic telescopes for automatic recognition of Supernovas as well as other transient events in collaboration with the Puckett Supernova Search Team. At the SAS2014 meeting, the discovery program, SNARE, was first described. Since then, it has been continuously improved to handle searches under a wide variety of atmospheric conditions. Currently, two telescopes are used to build a reference library while searching for PSN with a partial library. Since data is taken every night without clouds, we must deal with varying atmospheric and high background illumination from the moon. Software is configured to identify a PSN, reshoot for verification with options to change the run plan to acquire photometric or spectrographic data. The telescopes are 24-inch CDK24, with Alta U230 cameras, one in CA and one in NM. Images and run plans are sent between sites so the CA telescope can search while photometry is done in NM. Our goal is to find bright PSNs with magnitude 17.5 or less which is the limit of our planned spectroscopy. We present results from our first automated PSN discoveries and plans for PSN data acquisition.

  2. Open Source, Open Access, Open Review, Open Data. Initiativen zu mehr Offenheit in der digitalen Welt

    OpenAIRE

    Herb, Ulrich

    2011-01-01

    The article discusses the principles of openess, open access and open availability of information based on the examples of open access to scientific information, open government data, open geographical data and open source software.

  3. Open Source, Open Access, Open Review, Open Data. Initiativen zu mehr Offenheit in der digitalen Welt

    OpenAIRE

    Herb, Ulrich

    2011-01-01

    The article discusses the principles of openess, open access and open availability of information based on the examples of open access to scientific information, open government data, open geographical data and open source software.

  4. Investigating the temperature field on doors, frames and armor plate of large capacity coke ovens

    Energy Technology Data Exchange (ETDEWEB)

    Shashov, D.V.; Shustorovich, V.M.; Komolov, V.G.; Zhazhin, S.N.

    1985-06-01

    Experimental studies were carried out at the Altaiskii and Avdeevskii coking plants to determine the temperature field on the frames, doors and armor plating of coking batteries with a capacity of 41.6 m/sup 3/. It was established that for normal operation the temperature on metal parts of the combustion chambers remained stable. However, when gas is burned, the metal is subjected to rapid heating to temperatures exceeding those under normal operation. After the flame is extinguished, cooling is characterized by an accelerated temperature drop along the ribs and the temperature on the door and frame at the upper cross beam is higher than at other levels of the combustion chamber. Several recommendations on eliminating these temperature effects are made, e.g. using material with stable mechanical properties for doors, frames and armor plate. 4 references.

  5. A mass reduction effort of the electric and hybrid vehicle. [composite door panels

    Science.gov (United States)

    Freeman, R. B.; Jahnle, H. A.

    1980-01-01

    Weight reduction, cost competitiveness, and elimination of the intrusion beam resulted from the redesign and fabrication using composite materials of the door outer panel and intrusion beam from a Chevrolet Impala. The basis of the redesign involved replacing these two steel parts with a single compression molding using the unique approach of simultaneously curing a sheet molding compound outside panel with a continuous glass fiber intrusion strap. A weight reduction of nearly 11 pounds per door was achieved. Additional weight savings are possible by taking advantage of the elimination of the intrusion beam to design thinner door structures. The parts consolidation approach allows the composite structure to be cost competitive with the original steel design for both the lower production car models and for the near to midterm production vehicles using current state of the art composite production techniques. The design, prototype fabrication, costing, material, properties and compression molding production requirements are discussed.

  6. O triste quadro da saúde: análise de um out-door

    Directory of Open Access Journals (Sweden)

    Fernando Lefèvre

    1995-09-01

    Full Text Available Procura-se, neste trabalho, analisar um out­door presente na cidade de São Paulo, no mês de maio de 1993, e que intitula-se : "O triste quadro da saúde". Em função de vários elementos encontrados no texto e em função do contexto externo, o referido out-door permite e possibilita, pelo menos, duas leituras de sentidos absolutamente opostos, o que, certamente, implica, no caso de um out-door "assinado", uma escolha inadequada da mensagem por parte dos signatários. Em função disso, sugere-se cuidado e atenção para a ambigüidade presente, com muita freqüência, nas mensagens e nos discursos.

  7. Representation Discovery using Harmonic Analysis

    CERN Document Server

    Mahadevan, Sridhar

    2008-01-01

    Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu

  8. OpenAPC. Open-Access-Publikationskosten als Open Data

    OpenAIRE

    Tullney, Marco

    2015-01-01

    Präsentationsfolien zum Vortrag „OpenAPC. Open-Access-Publikationskosten als Open Data“ in der Session „Ausgestaltung eines wissenschaftsadäquaten APC-Marktes: Grundsätze, Finanzierungsansätze und Management“ der Open-Access-Tage 2015 in Zürich (https://www.open-access.net/community/open-access-tage/open-access-tage-2015-zuerich/programm/#c1974)

  9. Denton Vacuum Discovery-550 Sputterer

    Data.gov (United States)

    Federal Laboratory Consortium — Description: CORAL Name: Sputter 2 Similar to the existing 4-Gun Denton Discovery 22 Sputter system, with the following enhancements: Specifications / Capabilities:...

  10. Optogenetics enlightens neuroscience drug discovery.

    Science.gov (United States)

    Song, Chenchen; Knöpfel, Thomas

    2016-02-01

    Optogenetics - the use of light and genetics to manipulate and monitor the activities of defined cell populations - has already had a transformative impact on basic neuroscience research. Now, the conceptual and methodological advances associated with optogenetic approaches are providing fresh momentum to neuroscience drug discovery, particularly in areas that are stalled on the concept of 'fixing the brain chemistry'. Optogenetics is beginning to translate and transit into drug discovery in several key domains, including target discovery, high-throughput screening and novel therapeutic approaches to disease states. Here, we discuss the exciting potential of optogenetic technologies to transform neuroscience drug discovery.

  11. INDOOR MODELLING FROM SLAM-BASED LASER SCANNER: DOOR DETECTION TO ENVELOPE RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    L. Díaz-Vilariño

    2017-09-01

    Full Text Available Updated and detailed indoor models are being increasingly demanded for various applications such as emergency management or navigational assistance. The consolidation of new portable and mobile acquisition systems has led to a higher availability of 3D point cloud data from indoors. In this work, we explore the combined use of point clouds and trajectories from SLAM-based laser scanner to automate the reconstruction of building indoors. The methodology starts by door detection, since doors represent transitions from one indoor space to other, which constitutes an initial approach about the global configuration of the point cloud into building rooms. For this purpose, the trajectory is used to create a vertical point cloud profile in which doors are detected as local minimum of vertical distances. As point cloud and trajectory are related by time stamp, this feature is used to subdivide the point cloud into subspaces according to the location of the doors. The correspondence between subspaces and building rooms is not unambiguous. One subspace always corresponds to one room, but one room is not necessarily depicted by just one subspace, for example, in case of a room containing several doors and in which the acquisition is performed in a discontinue way. The labelling problem is formulated as combinatorial approach solved as a minimum energy optimization. Once the point cloud is subdivided into building rooms, envelop (conformed by walls, ceilings and floors is reconstructed for each space. The connectivity between spaces is included by adding the previously detected doors to the reconstructed model. The methodology is tested in a real case study.

  12. Use of risk assessment analysis by failure mode, effects, and criticality to reduce door-to-balloon time.

    Science.gov (United States)

    Khare, Rahul K; Nannicelli, Anna P; Powell, Emilie S; Seivert, Nicholas P; Adams, James G; Holl, Jane L

    2013-10-01

    The Centers for Medicare & Medicaid Services currently endorses a door-to-balloon time of 90 minutes or less for patients presenting to the emergency department (ED) with ST-segment elevation myocardial infarction. Recent evidence shows that a door-to-balloon time of 60 minutes significantly decreases inhospital mortality. We seek to use a proactive risk assessment method of failure mode, effects, and criticality analysis (FMECA) to evaluate door-to-balloon time process, to investigate how each component failure may affect the performance of a system, and to evaluate the frequency and the potential severity of harm of each failure. We conducted a 2-part study: FMECA of the door-to-balloon time system and process of care, and evaluation of a single institution's door-to-balloon time operational data using a retrospective observational cohort design. A multidisciplinary group of FMECA participants described the door-to-balloon time process to then create a comprehensive map and table listing all process steps and identified process failures, including their frequency, consequence, and causes. Door-to-balloon time operational data were assessed by "on" versus "off" hours. Fifty-one failure points were identified across 4 door-to-balloon time phases. Of the 12 high-risk failures, 58% occurred between ECG and catheterization laboratory activation. Total door-to-balloon time during on hours had a median time of 55 minutes (95% confidence interval 46 to 60 minutes) compared with 77 minutes (95% confidence interval 68 to 83 minutes) during off hours. The FMECA revealed clear areas of potential delay and vulnerability that can be addressed to decrease door-to-balloon time from 90 to 60 minutes. FMECAs can provide a robust assessment of potential risks and can serve as the platform for significant process improvement and system redesign for door-to-balloon time. Copyright © 2013 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

  13. The Optimization Design of Door Connecting Rod Bracket Structure of Civil Aircraft%民用飞机舱门连杆支架优化研究

    Institute of Scientific and Technical Information of China (English)

    袁修起

    2014-01-01

    The cabin latch mechanism of civil aircraft is to prevent the door accidentally open parts. When a jam occurs forced operation, it will produce a greater internal force. The equipment door latch mechanism is all stem shape and load is small except the connecting rod bracket. Connecting rod bracket structure is complex and load is bigger. Based on analyzingresistance load ,using the finite element analysis software HyperMesh and Opti-Struct , three kinds of structure forms of connecting rod bracket are simulated. With comparison and analysis, connecting rod bracket structure satisfied equipment doors functional requirements and prototype test purpose, which provides reference for the follow-up of the real product design.%民用飞机舱门闩机构是防止舱门意外开启的机构部件。当机构发生卡阻且强制操作时,将产生较大的内力。在设备舱门闩机构中除连杆支架外都是杆形件且载荷较小,连杆支架结构形式复杂且载荷较大。在分析机构卡阻载荷的基础上使用有限元分析软件HyperMesh和Opti-Struct对三种结构形式的连杆支架进行了数值模拟。通过对比分析,得到了满足样机设备舱门功能要求和试验目的的连杆支架形式,为后续真实产品的设计提供参考。

  14. SocialScope: Enabling Information Discovery on Social Content Sites

    CERN Document Server

    Amer-Yahia, Sihem; Yu, Cong

    2009-01-01

    Recently, many content sites have started encouraging their users to engage in social activities such as adding buddies on Yahoo! Travel and sharing articles with their friends on New York Times. This has led to the emergence of {\\em social content sites}, which is being facilitated by initiatives like OpenID (http://www.openid.net/) and OpenSocial (http://www.opensocial.org/). These community standards enable the open access to users' social profiles and connections by individual content sites and are bringing content-oriented sites and social networking sites ever closer. The integration of content and social information raises new challenges for {\\em information management and discovery} over such sites. We propose a logical architecture, named \\kw{SocialScope}, consisting of three layers, for tackling the challenges. The {\\em content management} layer is responsible for integrating, maintaining and physically accessing the content and social data. The {\\em information discovery} layer takes care of analyz...

  15. The Neutron's Discovery - 80 Years on

    Science.gov (United States)

    Rogers, John D.

    A brief review is given of selected highlights in scientific developments from the birth of modern nuclear physics at the end of the 19th century to the discovery of the neutron in 1932. This is followed by some important milestones in neutron and reactor physics that have led to our current understanding and implementation of nuclear technologies. The beginnings can be traced back to the discovery of X-rays by Roentgen, the identification of natural radioactivity by Becquerel and the discovery of the electron by Thomson, towards the end of the 19th Century. Rutherford was a key figure in experimental physics who determined the structure of the atom and who inspired his students at McGill, Manchester and Cambridge Universities (many of whom would become Nobel laureates) in the pursuit of their physics research. One of Rutherford's students, James Chadwick, had studied the work carried out by Bothe and Becker on alpha particle-induced disintegration of light elements which had led to their observation of high energy penetrating radiation that neither they nor the Joliot-Curies could identify. Chadwick knew that the only possible explanation was the emission of a neutron in the nuclear reaction. He carried out tests in the Cavendish Laboratory and submitted his now classical paper identifying the neutron to the periodical Nature in 1932. The discovery of the neutron and of nuclear fission in 1939 opened up new areas for scientific investigation, in, for example, astrophysics, geology, neutron and nuclear physics. The prospects for nuclear power in particular appeared to be unlimited and both civil and military applications have been actively pursued. Many new experimental facilities have been designed and built to provide intense sources of neutrons for research purposes. Work carried out in such centres is included in the programme of the 7th International Topical Meeting on Neutron Radiography, an important forum for discussion of the latest research work of this

  16. Interpretation of a discovery

    Directory of Open Access Journals (Sweden)

    Vučković Vladan

    2006-01-01

    Full Text Available The paper presents the development of the theory of asynchronous motors since Tesla’s discovery until the present day. The theory of steady state, as we know it today, was completed already during the first dozen of years. That was followed by a period of stagnation during a number of decades, when the theory of asynchronous motors was developed only in the framework of the general theory of electric machines, which was stimulated by the problems of the development of synchronous generators and big electric networks. It is only in our time that this simple motor, which was used for a long time just to perform crude tasks, became again the inspiration for the researchers and engineers who enabled it, with the help of power electronics and semi-conductor technology, to be used in the finest drives.

  17. Discovery with RSS retracted

    Science.gov (United States)

    1997-01-01

    The Rotating Service Structure has been retracted at Pad 39A. Discovery, the Space Shuttle for STS-82 Mission is ready for the launch of the second Hubble Space Telescope service mission. The payload consists of the Near Infrared Camera and Multi-Object Spectrometer (NICMOS) Which will be installed, the Fine Guidance Sensor #1 (FGS-1) and the Space Telescope Imaging Spectrograph (STIS) which will be installed. STS-82 will launch with a crew of seven at 3:54 a.m. February 11, 1997. The launch window is 65 minutes. The Mission Commander for STS-82 is Ken Bowersox. The purpose of the mission is to upgrade the scientific capabilities, service or replace aging components on the Telescope and provide a reboost to the optimum altitude.

  18. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    M Thoennessen

    2015-09-01

    Of the about 3000 isotopes presently known, about 20% have been discovered in fission. The history of fission as it relates to the discovery of isotopes as well as the various reaction mechanisms leading to isotope discoveries involving fission are presented.

  19. Service discovery using Bloom filters

    NARCIS (Netherlands)

    Goering, P.T.H.; Heijenk, Gerhard J.; Lelieveldt, B.P.F.; Haverkort, Boudewijn R.H.M.; de Laat, C.T.A.M.; Heijnsdijk, J.W.J.

    A protocol to perform service discovery in adhoc networks is introduced in this paper. Attenuated Bloom filters are used to distribute services to nodes in the neighborhood and thus enable local service discovery. The protocol has been implemented in a discrete event simulator to investigate the

  20. Discovery Learning Strategies in English

    Science.gov (United States)

    Singaravelu, G.

    2012-01-01

    The study substantiates that the effectiveness of Discovery Learning method in learning English Grammar for the learners at standard V. Discovery Learning is particularly beneficial for any student learning a second language. It promotes peer interaction and development of the language and the learning of concepts with content. Reichert and…

  1. Open Images

    DEFF Research Database (Denmark)

    Sanderhoff, Merete

    2013-01-01

    Museums around the world hold enormous troves of public domain artworks. In digitized form, they can be powerful tools for research and learning, as well as building blocks, in the hands of students, teachers, scholars, developers, and creative people. By opening up their digitized assets for reuse......, museums have a unique opportunity to broaden the scope of their public mission to serve and educate the public on 21st century media terms. What could be controversial about that? Art museums have a long legacy of restricting access to high quality images of artworks in order to protect them from improper...

  2. Open University

    CERN Document Server

    Pentz,M

    1975-01-01

    Michel Pentz est née en Afrique du Sud et venu au Cern en 1957 comme physicien et président de l'associaion du personnel. Il est également fondateur du mouvement Antiapartheid de Genève et a participé à la fondation de l'Open University en Grande-Bretagne. Il nous parle des contextes pédagogiques, culturels et nationaux dans lesquels la méthode peut s'appliquer.

  3. A Metadata Schema for Geospatial Resource Discovery Use Cases

    Directory of Open Access Journals (Sweden)

    Darren Hardy

    2014-07-01

    Full Text Available We introduce a metadata schema that focuses on GIS discovery use cases for patrons in a research library setting. Text search, faceted refinement, and spatial search and relevancy are among GeoBlacklight's primary use cases for federated geospatial holdings. The schema supports a variety of GIS data types and enables contextual, collection-oriented discovery applications as well as traditional portal applications. One key limitation of GIS resource discovery is the general lack of normative metadata practices, which has led to a proliferation of metadata schemas and duplicate records. The ISO 19115/19139 and FGDC standards specify metadata formats, but are intricate, lengthy, and not focused on discovery. Moreover, they require sophisticated authoring environments and cataloging expertise. Geographic metadata standards target preservation and quality measure use cases, but they do not provide for simple inter-institutional sharing of metadata for discovery use cases. To this end, our schema reuses elements from Dublin Core and GeoRSS to leverage their normative semantics, community best practices, open-source software implementations, and extensive examples already deployed in discovery contexts such as web search and mapping. Finally, we discuss a Solr implementation of the schema using a "geo" extension to MODS.

  4. Leveraging big data to transform target selection and drug discovery

    Science.gov (United States)

    Butte, AJ

    2016-01-01

    The advances of genomics, sequencing, and high throughput technologies have led to the creation of large volumes of diverse datasets for drug discovery. Analyzing these datasets to better understand disease and discover new drugs is becoming more common. Recent open data initiatives in basic and clinical research have dramatically increased the types of data available to the public. The past few years have witnessed successful use of big data in many sectors across the whole drug discovery pipeline. In this review, we will highlight the state of the art in leveraging big data to identify new targets, drug indications, and drug response biomarkers in this era of precision medicine. PMID:26659699

  5. 29 CFR 2700.56 - Discovery; general.

    Science.gov (United States)

    2010-07-01

    ...(c) or 111 of the Act has been filed. 30 U.S.C. 815(c) and 821. (e) Completion of discovery... 29 Labor 9 2010-07-01 2010-07-01 false Discovery; general. 2700.56 Section 2700.56 Labor... Hearings § 2700.56 Discovery; general. (a) Discovery methods. Parties may obtain discovery by one or...

  6. Opening address

    Science.gov (United States)

    Castagnoli, C.

    1994-01-01

    Ladies and Gentlemen My cordial thanks to you for participating in our workshop and to all those who have sponsored it. When in 1957 I attended the International Congress on Fundamental Constants held in Turin on the occasion of the first centenary of the death of Amedeo Avogadro, I did not expect that about thirty-five years later a small but representative number of distinguished scientists would meet here again, to discuss how to go beyond the sixth decimal figure of the Avogadro constant. At that time, the uncertainty of the value of this constant was linked to the fourth decimal figure, as reported in the book by DuMond and Cohen. The progress made in the meantime is universally acknowledged to be due to the discovery of x-ray interferometry. We are honoured that one of the two founding fathers, Prof. Ulrich Bonse, is here with us, but we regret that the other, Prof. Michael Hart, is not present. After Bonse and Hart's discovery, the x-ray crystal density method triggered, as in a chain reaction, the investigation of two other quantities related to the Avogadro constant—density and molar mass. Scientists became, so to speak, resonant and since then have directed their efforts, just to mention a few examples, to producing near-perfect silicon spheres and determining their density, to calibrating, with increasing accuracy, mass spectrometers, and to studying the degree of homogeneity of silicon specimens. Obviously, I do not need to explain to you why the Avogadro constant is important. I wish, however, to underline that it is not only because of its position among fundamental constants, as we all know very well its direct links with the fine structure constant, the Boltzmann and Faraday constants, the h/e ratio, but also because when a new value of NA is obtained, the whole structure of the fundamental constants is shaken to a lesser or greater extent. Let me also remind you that the second part of the title of this workshop concerns the silicon

  7. Opname van cadmium door gewassen in moestuinen in de Kempen: risico-inventarisatie en maatregelen

    NARCIS (Netherlands)

    Römkens, P.F.A.M.; Rietra, R.P.J.J.; Lijzen, J.P.A.; Otte, P.F.; Comans, R.N.J.

    2004-01-01

    Op basis van bestaande data is de opname van cadmium door enkele belangrijke moestuingewassen beschreven via een bodem-plant relatie. Gebruik makend van organische stof, pH, klei en het cadmiumgehalte van de bodem kan het gehalte in het gewas voorspeld worden. Met deze vergelijkingen is vervolgens

  8. The genetic basis of DOORS syndrome : an exome-sequencing study

    NARCIS (Netherlands)

    Campeau, Philippe M.; Kasperaviciute, Dalia; Lu, James T.; Burrage, Lindsay C.; Kim, Choel; Hori, Mutsuki; Powell, Berkley R.; Stewart, Fiona; Felix, Temis Maria; van den Ende, Jenneke; Wisniewska, Marzena; Kayserili, Huelya; Rump, Patrick; Nampoothiri, Sheela; Aftimos, Salim; Mey, Antje; Nair, Lal D. V.; Begleiter, Michael L.; De Bie, Isabelle; Meenakshi, Girish; Murray, Mitzi L.; Repetto, Gabriela M.; Golabi, Mahin; Blair, Edward; Male, Alison; Giuliano, Fabienne; Kariminejad, Ariana; Newman, William G.; Bhaskar, Sanjeev S.; Dickerson, Jonathan E.; Kerr, Bronwyn; Banka, Siddharth; Giltay, Jacques C.; Wieczorek, Dagmar; Tostevin, Anna; Wiszniewska, Joanna; Cheung, Sau Wai; Hennekam, Raoul C.; Gibbs, Richard A.; Lee, Brendan H.; Sisodiya, Sanjay M.

    2014-01-01

    Background Deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures (DOORS) syndrome is a rare autosomal recessive disorder of unknown cause. We aimed to identify the genetic basis of this syndrome by sequencing most coding exons in affected individuals. Methods Through a search o

  9. 16 CFR 1201.40 - Interpretation concerning bathtub and shower doors and enclosures.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Interpretation concerning bathtub and shower... Policy and Interpretation § 1201.40 Interpretation concerning bathtub and shower doors and enclosures. (a) Purpose and background. The purpose of this section is to clarify the scope of the terms “bathtub...

  10. "Wolves at the Schoolhouse Door": Comments and Impressions by a Beseiged Business Manager.

    Science.gov (United States)

    Coley, Joe D.

    1989-01-01

    The Education Writers Association report "Wolves at the Schoolhouse Door" examines the poor condition of public school buildings. The report, utilizing data from all the states and from personal contacts and interviews, presents statistics on enrollment, maintenance budgets, safety, financing, lack of data, and potential solutions. (MLF)

  11. Online uitlenen van e-books door bibliotheken: verkenning juridische mogelijkheden en economische effecten

    NARCIS (Netherlands)

    van der Noll, R.; Breemen, K.; Breemen, V.; Hugenholtz, B.; Brom, M.; Poort, J.

    2012-01-01

    Het uitlenen van e-books door openbare bibliotheken is in een groeiend aantal landen een realiteit. Dit rapport inventariseert deze praktijk en analyseert de juridische mogelijkheden voor en economische gevolgen van e-lending. In het economische deel van deze verkenning wordt onderzocht in welke

  12. 30 CFR 57.8531 - Construction and maintenance of ventilation doors.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Construction and maintenance of ventilation doors. 57.8531 Section 57.8531 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF... constructed of wood; (c) Maintained in good condition; (d) Self-closing, if manually operated; and...

  13. One-Door-One-Key Principle: Observations Regarding Integration of GM Authorization Procedures in the EU

    NARCIS (Netherlands)

    Meulen, van der B.M.J.; Yusuf, Neshe

    2015-01-01

    Under European Union (EU) law, genetically modified organisms (GMOs) for consumption require authorizations for cultivation, for use in human food, and for use in animal feed. The recast of the legislative framework in 2003 introduced the “one-door-one-key principle.” This principle links and integr

  14. Improving Emergency Department Door to Doctor Time and Process Reliability: A Successful Implementation of Lean Methodology.

    Science.gov (United States)

    El Sayed, Mazen J; El-Eid, Ghada R; Saliba, Miriam; Jabbour, Rima; Hitti, Eveline A

    2015-10-01

    The aim of this study is to determine the effectiveness of using lean management methods on improving emergency department door to doctor times at a tertiary care hospital.We performed a before and after study at an academic urban emergency department with 49,000 annual visits after implementing a series of lean driven interventions over a 20 month period. The primary outcome was mean door to doctor time and the secondary outcome was length of stay of both admitted and discharged patients. A convenience sample from the preintervention phase (February 2012) was compared to another from the postintervention phase (mid-October to mid-November 2013). Individual control charts were used to assess process stability.Postintervention there was a statistically significant decrease in the mean door to doctor time measure (40.0 minutes ± 53.44 vs 25.3 minutes ± 15.93 P < 0.001). The postintervention process was more statistically in control with a drop in the upper control limits from 148.8 to 72.9 minutes. Length of stay of both admitted and discharged patients dropped from 2.6 to 2.0 hours and 9.0 to 5.5 hours, respectively. All other variables including emergency department visit daily volumes, hospital occupancy, and left without being seen rates were comparable.Using lean change management techniques can be effective in reducing door to doctor time in the Emergency Department and improving process reliability.

  15. Identifying Patient Door-to-Room Goals to Minimize Left-Without-Being-Seen Rates

    Directory of Open Access Journals (Sweden)

    Shea Pielsticker

    2015-10-01

    Full Text Available Introduction: Emergency department (ED patients in the leave-without-being-seen (LWBS group risk problems of inefficiency, medical risk, and financial loss. The goal at our hospital is to limit LWBS to 60min. Multivariate logistic regression was used to assess for DoorRoom cutoffs predicting high LWBS, while adjusting for patient acuity (triage scores and admission % and operations parameters. We used predictive marginal probability to assess utility of the regression-generated cutoffs. We defined statistical significance at p85% of meeting the LWBS goal. A secondary DoorRoom cutoff was indicated at 35’, to prevent a precipitous drop-off in likelihood of meeting the LWBS goal, from 61.1% at 35’ to 34.4% at 40’. Predictive marginal analysis using multivariate techniques to control for operational and patient-acuity factors confirmed the 20’ and 35’ cutoffs as significant (p35’ were a further 75% less likely to meet the LWBS goal than days with DoorRoom of 21-35’ (OR 0.25, 95% CI [0.15-0.41]. Conclusion: Operationally useful DoorRoom cutoffs can be identified, which allow for rational establishment of performance goals for the ED attempting to minimize LWBS.

  16. Bedrijfsrestaurant als springplank : acceptatie van nieuwe biologische producten door introductie in de catering

    NARCIS (Netherlands)

    Reinders, M.J.; Zimmermann, K.L.; Berg, van den I.

    2009-01-01

    Dit onderzoek verschaft inzicht in het overdrachtsmechanisme tussen de introductie van nieuwe producten in de catering (bedrijfsrestaurants) en de acceptatie van deze nieuwe producten door de consumenten. In Deel I van het rapport wordt een conceptueel model gepresenteerd dat als handvat dient voor

  17. 3D modeling of building indoor spaces and closed doors from imagery and point clouds.

    Science.gov (United States)

    Díaz-Vilariño, Lucía; Khoshelham, Kourosh; Martínez-Sánchez, Joaquín; Arias, Pedro

    2015-02-03

    3D models of indoor environments are increasingly gaining importance due to the wide range of applications to which they can be subjected: from redesign and visualization to monitoring and simulation. These models usually exist only for newly constructed buildings; therefore, the development of automatic approaches for reconstructing 3D indoors from imagery and/or point clouds can make the process easier, faster and cheaper. Among the constructive elements defining a building interior, doors are very common elements and their detection can be very useful either for knowing the environment structure, to perform an efficient navigation or to plan appropriate evacuation routes. The fact that doors are topologically connected to walls by being coplanar, together with the unavoidable presence of clutter and occlusions indoors, increases the inherent complexity of the automation of the recognition process. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors based on point clouds and images. The methodology analyses the visibility problem of indoor environments and goes in depth with door candidate detection. The presented approach is tested in real data sets showing its potential with a high door detection rate and applicability for robust and efficient envelope reconstruction.

  18. 3D Modeling of Building Indoor Spaces and Closed Doors from Imagery and Point Clouds

    Directory of Open Access Journals (Sweden)

    Lucía Díaz-Vilariño

    2015-02-01

    Full Text Available 3D models of indoor environments are increasingly gaining importance due to the wide range of applications to which they can be subjected: from redesign and visualization to monitoring and simulation. These models usually exist only for newly constructed buildings; therefore, the development of automatic approaches for reconstructing 3D indoors from imagery and/or point clouds can make the process easier, faster and cheaper. Among the constructive elements defining a building interior, doors are very common elements and their detection can be very useful either for knowing the environment structure, to perform an efficient navigation or to plan appropriate evacuation routes. The fact that doors are topologically connected to walls by being coplanar, together with the unavoidable presence of clutter and occlusions indoors, increases the inherent complexity of the automation of the recognition process. In this work, we present a pipeline of techniques used for the reconstruction and interpretation of building interiors based on point clouds and images. The methodology analyses the visibility problem of indoor environments and goes in depth with door candidate detection. The presented approach is tested in real data sets showing its potential with a high door detection rate and applicability for robust and efficient envelope reconstruction.

  19. The Glass Door: The Gender Composition of Newly-Hired Workers Across Hierarchical Job Levels

    NARCIS (Netherlands)

    Hassink, W.H.J.; Russo, G.

    2010-01-01

    This paper examines the gender composition of the flow of new hirees along the organizational hierarchy of jobs. We find that women have a reduced chance to be hired at higher hierarchical levels. We refer to this phenomenon as the “glass door”. The glass door consists of an absolute and a relative

  20. Radiologische aspecten van opslag en lozing van afvalstoffen door de fosfaatindustrie

    NARCIS (Netherlands)

    Eggink GJ; LSO

    1995-01-01

    Bij de produktie van fosfaatkunstmest uit fosfaaterts komt fosfogips vrij. Dit fosfogips mag door zijn hoge radioactiviteit niet direct verwerkt worden. De verwijdering van radionucliden uit het ruwe gips vindt nog slechts op zeer geringe schaal plaats. Het overgrote deel wordt op land opgeslage