WorldWideScience

Sample records for discoveries principally related

  1. Principals' Perceptions of School Public Relations

    Science.gov (United States)

    Morris, Robert C.; Chan, Tak Cheung; Patterson, Judith

    2009-01-01

    This study was designed to investigate school principals' perceptions on school public relations in five areas: community demographics, parental involvement, internal and external communications, school council issues, and community resources. Findings indicated that principals' concerns were as follows: rapid population growth, change of…

  2. Process Knowledge Discovery Using Sparse Principal Component Analysis

    DEFF Research Database (Denmark)

    Gao, Huihui; Gajjar, Shriram; Kulahci, Murat

    2016-01-01

    have been an active area of research. Among the methods used, principal component analysis (PCA) is a well-established technique that allows for dimensionality reduction for large data sets by finding new uncorrelated variables, namely principal components (PCs). However, it is difficult to interpret...

  3. Constrained principal component analysis and related techniques

    CERN Document Server

    Takane, Yoshio

    2013-01-01

    In multivariate data analysis, regression techniques predict one set of variables from another while principal component analysis (PCA) finds a subspace of minimal dimensionality that captures the largest variability in the data. How can regression analysis and PCA be combined in a beneficial way? Why and when is it a good idea to combine them? What kind of benefits are we getting from them? Addressing these questions, Constrained Principal Component Analysis and Related Techniques shows how constrained PCA (CPCA) offers a unified framework for these approaches.The book begins with four concre

  4. Literature-Related Discovery: A Review

    National Research Council Canada - National Science Library

    Kostoff, Ronald N; Block, Joel A; Solka, Jeffrey L; Briggs, Michael B; Rushenberg, Robert L; Stump, Jesse A; Johnson, Dustin; Lyons, Terence J; Wyatt, Jeffrey R

    2007-01-01

    .... Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked to produce novel interesting, plausible, and intelligible knowledge (i.e...

  5. Subjective performance evaluations and reciprocity in principal-agent relations

    DEFF Research Database (Denmark)

    Sebald, Alexander Christopher; Walzl, Markus

    2014-01-01

    . In contrast to existing models of reciprocity, we find that agents tend to sanction whenever the feedback of principals is below their subjective self-evaluations even if agents' pay-offs are independent of it. In turn, principals provide more positive feedback (relative to their actual performance assessment......We conduct a laboratory experiment with agents working on, and principals benefiting from, a real effort task in which the agents' performance can only be evaluated subjectively. Principals give subjective performance feedback to agents, and agents have an opportunity to sanction principals...

  6. Public Relations for Principals. "A Guidebook for the Pennsylvania Administrator."

    Science.gov (United States)

    Pennsylvania School Boards Association, Inc., Harrisburg.

    This report discusses what makes news, what people want to read, and how to write news releases or other informative bulletins and brochures. Also included are a description of principal-reporter-editor relations, some layout and typography data, and photography instructions. (JF)

  7. Literature-Related Discovery: A Review

    Science.gov (United States)

    2007-11-05

    disaggregation; Guar Gum for decrease in plasma fibrinogen and viscosity; Cell hydration to improve cell deformity and increase arm blood flow. This...discoveries to insure that they were indeed unique. Some potential discoveries include: The use of plasmin to deter cell adhesion for use in non...2006] have generated a semantic space approach that bears some similarities to LSI. It is based on the Hyperspace Analogue to Language (HAL

  8. INTERNATIONAL REGULATORY DOCUMENTS WITH SPECIAL REGIME USED BY ROMANIAN PRINCIPALITIES IN RELATIONS WITH THE OTTOMAN AND THE RUSSIAN EMPIRE

    Directory of Open Access Journals (Sweden)

    Ion Gr. IONESCU

    2015-11-01

    Full Text Available Although the existence of some regulating documents, called capitulations, concerning the relations on various plans, between the Romanian Country, Moldavia and the Ottoman Empire was known, the first one of these diplomatic documents, that have been operational over time, was discovered only in 1974. It was an act that had been granted to Mihnea Turkished, in the year 1585. This important discovery has been completed, with others that had the same purpose. In fact, they were some diplomatic documents, with the role of Treaty, which has regulated quite explicitly, the status of the two Romanian principalities, in relations with the suzerain power. The most important fact of their contents was the recognition of the internal autonomy of principalities and a certain degree of freedom, in relations outside the borders. The price was that Romanian countries paid was ,however, to never become hostile to Ottoman interests, integrating in the Ottoman foreign policy and paying an annual tribute.

  9. Concept relation discovery and innovation enabling technology (CORDIET)

    NARCIS (Netherlands)

    Poelmans, J.; Elzinga, P.; Neznanov, A.; Viaene, S.; Kuznetsov, S.O.; Ignatov, D.; Dedene, G.

    2011-01-01

    Concept Relation Discovery and Innovation Enabling Technology (CORDIET), is a toolbox for gaining new knowledge from unstructured text data. At the core of CORDIET is the C-K theory which captures the essential elements of innovation. The tool uses Formal Concept Analysis (FCA), Emergent Self

  10. An Examination of Principal Technology Proficiency as It Relates to Leadership Styles

    Science.gov (United States)

    Massey, Shawn L.

    2014-01-01

    Research is limited when it comes to measuring principals' technology use as it relates to their leadership behaviors. Increasingly, principals are required to assume leadership responsibilities in areas with which they are unfamiliar and for which they have received little training (Flanagan & Jacobsen, 2003). Based on the requirement for…

  11. Impact of the discovery of crude oil on inter-group relations between ...

    African Journals Online (AJOL)

    Impact of the discovery of crude oil on inter-group relations between Isoko and her immediate neighbours in the western Niger Delta of Nigeria. ... The article shows that the discovery of crude oil petroleum in the western Niger Delta marked a watershed in the history of intergroup relations in the area. Keywords: Discovery ...

  12. Literature-related discovery techniques applied to ocular disease : a vitreous restoration example

    NARCIS (Netherlands)

    Kostoff, Ronald N.; Los, Leonoor I.

    2013-01-01

    Purpose of reviewLiterature-related discovery and innovation (LRDI) is a text mining approach for bridging unconnected disciplines to hypothesize radical discovery. Application to medical problems involves identifying key disease symptoms, and identifying causes and treatments for those symptoms

  13. Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease.

    Science.gov (United States)

    Taguchi, Y-h; Iwadate, Mitsuo; Umeyama, Hideaki

    2015-04-30

    Feature extraction (FE) is difficult, particularly if there are more features than samples, as small sample numbers often result in biased outcomes or overfitting. Furthermore, multiple sample classes often complicate FE because evaluating performance, which is usual in supervised FE, is generally harder than the two-class problem. Developing sample classification independent unsupervised methods would solve many of these problems. Two principal component analysis (PCA)-based FE, specifically, variational Bayes PCA (VBPCA) was extended to perform unsupervised FE, and together with conventional PCA (CPCA)-based unsupervised FE, were tested as sample classification independent unsupervised FE methods. VBPCA- and CPCA-based unsupervised FE both performed well when applied to simulated data, and a posttraumatic stress disorder (PTSD)-mediated heart disease data set that had multiple categorical class observations in mRNA/microRNA expression of stressed mouse heart. A critical set of PTSD miRNAs/mRNAs were identified that show aberrant expression between treatment and control samples, and significant, negative correlation with one another. Moreover, greater stability and biological feasibility than conventional supervised FE was also demonstrated. Based on the results obtained, in silico drug discovery was performed as translational validation of the methods. Our two proposed unsupervised FE methods (CPCA- and VBPCA-based) worked well on simulated data, and outperformed two conventional supervised FE methods on a real data set. Thus, these two methods have suggested equivalence for FE on categorical multiclass data sets, with potential translational utility for in silico drug discovery.

  14. Automotive Exterior Noise Optimization Using Grey Relational Analysis Coupled with Principal Component Analysis

    Science.gov (United States)

    Chen, Shuming; Wang, Dengfeng; Liu, Bo

    This paper investigates optimization design of the thickness of the sound package performed on a passenger automobile. The major characteristics indexes for performance selected to evaluate the processes are the SPL of the exterior noise and the weight of the sound package, and the corresponding parameters of the sound package are the thickness of the glass wool with aluminum foil for the first layer, the thickness of the glass fiber for the second layer, and the thickness of the PE foam for the third layer. In this paper, the process is fundamentally with multiple performances, thus, the grey relational analysis that utilizes grey relational grade as performance index is especially employed to determine the optimal combination of the thickness of the different layers for the designed sound package. Additionally, in order to evaluate the weighting values corresponding to various performance characteristics, the principal component analysis is used to show their relative importance properly and objectively. The results of the confirmation experiments uncover that grey relational analysis coupled with principal analysis methods can successfully be applied to find the optimal combination of the thickness for each layer of the sound package material. Therefore, the presented method can be an effective tool to improve the vehicle exterior noise and lower the weight of the sound package. In addition, it will also be helpful for other applications in the automotive industry, such as the First Automobile Works in China, Changan Automobile in China, etc.

  15. Subjective Performance Evaluations, Self-esteem, and Ego-threats in Principal-agent Relations

    DEFF Research Database (Denmark)

    Sebald, Alexander Christopher; Walzl, Markus

    find that agents sanction whenever the feedback of principals is below their subjective self-evaluations even if the agents' payoff is independent of the principals' feedback. Based on our experimental analysis we propose a principal-agent model with subjective performance evaluations that accommodates...

  16. Retrieval of Legal Information Through Discovery Layers: A Case Study Related to Indian Law Libraries

    Directory of Open Access Journals (Sweden)

    Kushwah, Shivpal Singh

    2016-09-01

    Full Text Available Purpose. The purpose of this paper is to analyze and evaluate discovery layer search tools for retrieval of legal information in Indian law libraries. This paper covers current practices in legal information retrieval with special reference to Indian academic law libraries, and analyses its importance in the domain of law.Design/Methodology/Approach. A web survey and observational study method are used to collect the data. Data related to the discovery tools were collected using email and further discussion held with the discovery layer/ tool /product developers and their representatives.Findings. Results show that most of the Indian law libraries are subscribing to bundles of legal information resources such as Hein Online, JSTOR, LexisNexis Academic, Manupatra, Westlaw India, SCC web, AIR Online (CDROM, and so on. International legal and academic resources are compatible with discovery tools because they support various standards related to online publishing and dissemination such as OAI/PMH, Open URL, MARC21, and Z39.50, but Indian legal resources such as Manupatra, Air, and SCC are not compatible with the discovery layers. The central index is one of the important components in a discovery search interface, and discovery layer services/tools could be useful for Indian law libraries also if they can include multiple legal and academic resources in their central index. But present practices and observations reveal that discovery layers are not providing facility to cover legal information resources. Therefore, in the present form, discovery tools are not very useful; they are an incomplete and half solution for Indian libraries because all available Indian legal resources available in the law libraries are not covered.Originality/Value. Very limited research or published literature is available in the area of discovery layers and their compatibility with legal information resources.

  17. The Relation Between Collective Bargaining Environments, and Principal Selection and Organizational Behavior Perceptions.

    Science.gov (United States)

    Caldwell, William E.; Curfman, Walter L.

    This study examined the effect of collective bargaining environments on principal hiring and school administrator behavior perceptions. Specifically, researchers hypothesized that small or medium sized school districts that engage in collective bargaining will hire significantly more outsiders as principals than will similar districts in…

  18. Time-Frequency Data Reduction for Event Related Potentials: Combining Principal Component Analysis and Matching Pursuit.

    Science.gov (United States)

    Aviyente, Selin; Bernat, Edward M; Malone, Stephen M; Iacono, William G

    2010-01-01

    Joint time-frequency representations offer a rich representation of event related potentials (ERPs) that cannot be obtained through individual time or frequency domain analysis. This representation, however, comes at the expense of increased data volume and the difficulty of interpreting the resulting representations. Therefore, methods that can reduce the large amount of time-frequency data to experimentally relevant components are essential. In this paper, we present a method that reduces the large volume of ERP time-frequency data into a few significant time-frequency parameters. The proposed method is based on applying the widely-used matching pursuit (MP) approach, with a Gabor dictionary, to principal components extracted from the time-frequency domain. The proposed PCA-Gabor decomposition is compared with other time-frequency data reduction methods such as the time-frequency PCA approach alone and standard matching pursuit methods using a Gabor dictionary for both simulated and biological data. The results show that the proposed PCA-Gabor approach performs better than either the PCA alone or the standard MP data reduction methods, by using the smallest amount of ERP data variance to produce the strongest statistical separation between experimental conditions.

  19. Time-Frequency Data Reduction for Event Related Potentials: Combining Principal Component Analysis and Matching Pursuit

    Directory of Open Access Journals (Sweden)

    Selin Aviyente

    2010-01-01

    Full Text Available Joint time-frequency representations offer a rich representation of event related potentials (ERPs that cannot be obtained through individual time or frequency domain analysis. This representation, however, comes at the expense of increased data volume and the difficulty of interpreting the resulting representations. Therefore, methods that can reduce the large amount of time-frequency data to experimentally relevant components are essential. In this paper, we present a method that reduces the large volume of ERP time-frequency data into a few significant time-frequency parameters. The proposed method is based on applying the widely used matching pursuit (MP approach, with a Gabor dictionary, to principal components extracted from the time-frequency domain. The proposed PCA-Gabor decomposition is compared with other time-frequency data reduction methods such as the time-frequency PCA approach alone and standard matching pursuit methods using a Gabor dictionary for both simulated and biological data. The results show that the proposed PCA-Gabor approach performs better than either the PCA alone or the standard MP data reduction methods, by using the smallest amount of ERP data variance to produce the strongest statistical separation between experimental conditions.

  20. Discovery of functional and approximate functional dependencies in relational databases

    Directory of Open Access Journals (Sweden)

    Ronald S. King

    2003-01-01

    Full Text Available This study develops the foundation for a simple, yet efficient method for uncovering functional and approximate functional dependencies in relational databases. The technique is based upon the mathematical theory of partitions defined over a relation's row identifiers. Using a levelwise algorithm the minimal non-trivial functional dependencies can be found using computations conducted on integers. Therefore, the required operations on partitions are both simple and fast. Additionally, the row identifiers provide the added advantage of nominally identifying the exceptions to approximate functional dependencies, which can be used effectively in practical data mining applications.

  1. Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery.

    Science.gov (United States)

    Verstraeten, Aline; Alaerts, Maaike; Van Laer, Lut; Loeys, Bart

    2016-06-01

    Marfan syndrome (MFS) is a rare, autosomal-dominant, multisystem disorder, presenting with skeletal, ocular, skin, and cardiovascular symptoms. Significant clinical overlap with other systemic connective tissue diseases, including Loeys-Dietz syndrome (LDS), Shprintzen-Goldberg syndrome (SGS), and the MASS phenotype, has been documented. In MFS and LDS, the cardiovascular manifestations account for the major cause of patient morbidity and mortality, rendering them the main target for therapeutic intervention. Over the past decades, gene identification studies confidently linked the aforementioned syndromes, as well as nonsyndromic aneurysmal disease, to genetic defects in proteins related to the transforming growth factor (TGF)-β pathway, greatly expanding our knowledge on the disease mechanisms and providing us with novel therapeutic targets. As a result, the focus of the developing pharmacological treatment strategies is shifting from hemodynamic stress management to TGF-β antagonism. In this review, we discuss the insights that have been gained in the molecular biology of MFS and related disorders over the past 25 years. © 2016 WILEY PERIODICALS, INC.

  2. The quality of media reports on discoveries related to human genetic diseases.

    Science.gov (United States)

    Holtzman, Neil A; Bernhardt, Barbara A; Mountcastle-Shah, Eliza; Rodgers, Joann E; Tambor, Ellen; Geller, Gail

    2005-01-01

    To examine (1) the quality of media reports (newspapers, television and public radio) of genetic discoveries with medical relevance and (2) factors related to the completeness and balance of the stories. Analysis of the accuracy, balance, and completeness of 228 media stories reporting 24 genetic discoveries between 1996 and 2000 using a previously validated instrument. Although usually accurate, the stories contained only 45.5 +/- 13.8% (mean +/- SD) of relevant items. Stories appearing on television and stories reporting discoveries of genes for rare diseases were the least complete. Stories in non-US English-speaking newspapers included more content items per word than US stories. Less balanced stories exaggerated the benefits of discoveries, ignored possible risks, and did not present a range of expert opinion. Scientists were sometimes the source of exaggeration. To increase the quality of media reports about genetic discoveries, stories should include more relevant items and be written by journalists skilled in science writing. Scientists will have to resist the tendency to exaggerate. These conclusions may apply to media stories of other discoveries as well.

  3. ROR nuclear receptors: structures, related diseases, and drug discovery.

    Science.gov (United States)

    Zhang, Yan; Luo, Xiao-yu; Wu, Dong-hai; Xu, Yong

    2015-01-01

    Nuclear receptors (NRs) are ligand-regulated transcription factors that regulate metabolism, development and immunity. The NR superfamily is one of the major classes of drug targets for human diseases. Retinoic acid receptor-related orphan receptor (ROR) α, β and γ belong to the NR superfamily, and these receptors are still considered as 'orphan' receptors because the identification of their endogenous ligands has been controversial. Recent studies have demonstrated that these receptors are regulated by synthetic ligands, thus emerge as important drug targets for the treatment of multiple sclerosis, rheumatoid arthritis, psoriasis, etc. Studying the structural basis and ligand development of RORs will pave the way for a better understanding of the roles of these receptors in human diseases. Here, we review the structural basis, disease relevance, strategies for ligand identification, and current status of development of therapeutic ligands for RORs.

  4. The Degree of Schools Principals Practicing Innovation and Its Relation with the Teachers' Professional Development

    Science.gov (United States)

    Abu-Shreah, Mohammad; Zidan, Hiam

    2017-01-01

    The study aims to know the degree of schools principals practicing innovation and its relationship with the teachers' professional development; the population of the study is consisted of all male and female teachers numbering to 415 teachers; the sample of the study is consisted of 205 male and female teachers from members of the study…

  5. Predictive Ability of Variables Related to the Aspects of School Principals' Management

    Science.gov (United States)

    Lukaš, Mirko; Jankovic, Boris

    2014-01-01

    The authors of this research paper believe that school principals play an irreplaceable role in raising the school efficiency. Their role is rather neglected in the Croatian academic debates on improving the quality of school system. This research intends to enhance the scientific level of their position as irreplaceable factors in a school…

  6. Relations between Prejudice, Cultural Intelligence and Level of Entrepreneurship: A Study of School Principals

    Science.gov (United States)

    Baltaci, Ali

    2017-01-01

    The aim of this study is to determine the mediating role of prejudice in the relationship between the cultural intelligence of school principals and the level of entrepreneurship. The design of this study was classified as correlational survey research. This study was designed by quantitative research method. The universe of this study constitutes…

  7. Separating Wheat from Chaff: How Secondary School Principals' Core Values and Beliefs Influence Decision-Making Related to Mandates

    Science.gov (United States)

    Larsen, Donald E.; Hunter, Joseph E.

    2014-01-01

    Research conducted by Larsen and Hunter (2013, February) identified a clear pattern in secondary school principals' decision-making related to mandated change: more than half of participants' decisions were based on core values and beliefs, requiring value judgments. Analysis of themes revealed that more than half of administrative decisions…

  8. Localization of the event-related potential novelty response as defined by principal components analysis.

    Science.gov (United States)

    Dien, Joseph; Spencer, Kevin M; Donchin, Emanuel

    2003-10-01

    Recent research indicates that novel stimuli elicit at least two distinct components, the Novelty P3 and the P300. The P300 is thought to be elicited when a context updating mechanism is activated by a wide class of deviant events. The functional significance of the Novelty P3 is uncertain. Identification of the generator sources of the two components could provide additional information about their functional significance. Previous localization efforts have yielded conflicting results. The present report demonstrates that the use of principal components analysis (PCA) results in better convergence with knowledge about functional neuroanatomy than did previous localization efforts. The results are also more convincing than that obtained by two alternative methods, MUSIC-RAP and the Minimum Norm. Source modeling on 129-channel data with BESA and BrainVoyager suggests the P300 has sources in the temporal-parietal junction whereas the Novelty P3 has sources in the anterior cingulate.

  9. Multivariate analysis of remote LIBS spectra using partial least squares, principal component analysis, and related techniques

    Energy Technology Data Exchange (ETDEWEB)

    Clegg, Samuel M [Los Alamos National Laboratory; Barefield, James E [Los Alamos National Laboratory; Wiens, Roger C [Los Alamos National Laboratory; Sklute, Elizabeth [MT HOLYOKE COLLEGE; Dyare, Melinda D [MT HOLYOKE COLLEGE

    2008-01-01

    Quantitative analysis with LIBS traditionally employs calibration curves that are complicated by the chemical matrix effects. These chemical matrix effects influence the LIBS plasma and the ratio of elemental composition to elemental emission line intensity. Consequently, LIBS calibration typically requires a priori knowledge of the unknown, in order for a series of calibration standards similar to the unknown to be employed. In this paper, three new Multivariate Analysis (MV A) techniques are employed to analyze the LIBS spectra of 18 disparate igneous and highly-metamorphosed rock samples. Partial Least Squares (PLS) analysis is used to generate a calibration model from which unknown samples can be analyzed. Principal Components Analysis (PCA) and Soft Independent Modeling of Class Analogy (SIMCA) are employed to generate a model and predict the rock type of the samples. These MV A techniques appear to exploit the matrix effects associated with the chemistries of these 18 samples.

  10. Grey Relational Analysis Coupled with Principal Component Analysis for Optimization of Stereolithography Process to Enhance Part Quality

    Science.gov (United States)

    Raju, B. S.; Sekhar, U. Chandra; Drakshayani, D. N.

    2017-08-01

    The paper investigates optimization of stereolithography process for SL5530 epoxy resin material to enhance part quality. The major characteristics indexed for performance selected to evaluate the processes are tensile strength, Flexural strength, Impact strength and Density analysis and corresponding process parameters are Layer thickness, Orientation and Hatch spacing. In this study, the process is intrinsically with multiple parameters tuning so that grey relational analysis which uses grey relational grade as performance index is specially adopted to determine the optimal combination of process parameters. Moreover, the principal component analysis is applied to evaluate the weighting values corresponding to various performance characteristics so that their relative importance can be properly and objectively desired. The results of confirmation experiments reveal that grey relational analysis coupled with principal component analysis can effectively acquire the optimal combination of process parameters. Hence, this confirm that the proposed approach in this study can be an useful tool to improve the process parameters in stereolithography process, which is very useful information for machine designers as well as RP machine users.

  11. THE USE OF PRINCIPAL COMPONENT ANALYSIS IN IDENTIFYING AND INTEGRATING VARIABLES RELATED TO FORAGE QUALITY AND METHANE PRODUCTION

    Directory of Open Access Journals (Sweden)

    A. Jayanegara

    2014-10-01

    Full Text Available This research was aimed to explore the use of multivariate statistics i.e. principal componentanalysis (PCA in identifying and integrating variables related to forage quality and ruminal methaneproduction, and in classifying forage species into both characteristics. Seventeen plants were used as adatabase for the above mentioned purposes. Plant samples were determined for their chemicalcomposition, cumulative gas production (represents the nutrient degradation and methane productionafter 24 hours of fermentation period using the Hohenheim gas test. The results showed that the PCAcould clearly identify factors related to forage quality and methane production and separated them intodifferent principal components (PC. The obtained PC1 was related to methane production andsubstantially influenced positively by crude protein, NDF, ADF (positive, total phenols, total tannins,condensed tannins and tannin activity (negative. On the other hand, the obtained PC2 was related tocumulative gas production (forage quality and substantially influenced by crude protein (positive,NDF, ADF and condensed tannins (negative. Classification and screening of forages that have highquality and low methane production are possible using the PCA technique. Rhenum undulatum,Peltiphyllum peltatum and Rhus typhina were found to have such desired characteristics.

  12. What Motivates Principals?

    Science.gov (United States)

    Iannone, Ron

    1973-01-01

    Achievement and recognition were mentioned as factors appearing with greater frequency in principal's job satisfactions; school district policy and interpersonal relations were mentioned as job dissatisfactions. (Editor)

  13. Discovery Mondays - “Relativity Theory... strange! Did you say strange?”

    CERN Multimedia

    2005-01-01

    We all know that famous equation E=mc2, but do you know its true significance? Relativity theory: what is the meaning of this strange concept which plunged the physics world into turmoil 100 years ago? What effects can be observed today? Did you know that the GPS system would not work if relativity was not taken into account? The next Discovery Monday will take you on a journey into a strange world. You will be able to witness for yourselves the consequences of Einstein's theories. How, for example, can relativity theory be tested by eclipses? What consequences does it have for the accelerators at CERN? How can it be used to measure the mass of enormous black holes? And finally, how is it linked to the puzzle surrounding the missing mass of the Universe? As part of the World Year of Physics, the next Discovery Monday will be dedicated to one of the theories that Einstein published in 1905, his “annus mirabilis”. Join us at the Microcosm (Reception Building 33, Meyrin site), on Monday 5th September ...

  14. Discovery Mondays - “Relativity Theory... strange! Did you say strange?”

    CERN Multimedia

    2005-01-01

    We all know that famous equation E=mc2, but do you know its true significance? Relativity theory: what is the meaning of this strange concept which plunged the physics world into turmoil 100 years ago? What effects can be observed today? Did you know that the GPS system would not work if relativity was not taken into account? The next Discovery Monday will take you on a journey into a strange world. You will be able to witness for yourselves the consequences of Einstein's theories. How, for example, can relativity theory be tested by eclipses? What consequences does it have for the accelerators at CERN? How can it be used to measure the mass of enormous black holes? And finally, how is it linked to the puzzle surrounding the missing mass of the Universe? As part of the World Year of Physics, the next Discovery Monday will be dedicated to one of the theories that Einstein published in 1905, his “annus mirabilis”. Join us at the Microcosm (Reception Building 33, Meyrin site), on Monday 5th Septemb...

  15. PRINCIPAL'S LEADERSHIP STYLE, AS PERCEIVED BY TEACHERS, IN RELATION TO TEACHER'S EXPERIENCE FACTOR OF SCHOOL CLIMATE IN ELEMENTARY SCHOOLS

    Directory of Open Access Journals (Sweden)

    Gabriel Pinkas

    2017-09-01

    Full Text Available The experience of the environment in which the activity is performed is a significant factor of the outcome of this activity, that is, the efficiency of the work and the degree of achieving the goal. Within the work environment, physical and social conditions can be observed. The first, which includes material and technical means, are mostly static, easily perceivable and measurable. Others, which include social relations, are much more susceptible to change, more difficult to perceive and measure, and their experience with different individuals within the same group can be more distinct. Although all members of the group participate in group dynamics and relationships, not all are equally relevant to these processes. Considering the position that carries the right and responsibility of setting up a vision and mission, setting goals, creating conditions for work, making decisions and providing feedback, the leader is in most cases crucial. This paper analyzes the role of elementary school principals in creating a school climate, as a non - material environment in which educational activity is carried out, and in this sense it is a specific group / work organization. An estimate was used to measure both variables, i.e. teacher's experience. The instruments used are Multifactor Leadership Questionnaire - MLQ (Avolio and Bass and School Level Environment Questionnaire - SLEQ (Johnson, Stevens and Zvoch. The survey was conducted in elementary schools in the wider city area of Tuzla, on a sample of 467 teachers and 25 principals. In statistical data processing, multiple regression (Ordinary least squares and direct square discriminatory analysis were applied. The obtained results point to the connection between the perceived leadership style of elementary school principals and the school climate experienced by teachers, especially in the field of innovation in teaching and mutual cooperation.

  16. First-Year Principals in Urban School Districts: How Actions and Working Conditions Relate to Outcomes. Technical Report

    Science.gov (United States)

    Burkhauser, Susan; Gates, Susan M.; Hamilton, Laura S.; Ikemoto, Gina Schuyler

    2012-01-01

    Principals new to their school face a variety of challenges that can influence their likelihood of improving their schools' performance and their likelihood of remaining the principal. Understanding the actions that principals take and the working conditions they face in the first year can inform efforts to promote school improvement and principal…

  17. Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases.

    Science.gov (United States)

    Nishimura, Yuhei; Hara, Hideaki

    2016-01-01

    Excessive oxidative stress induces dysregulation of functional networks in the retina, resulting in retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Although various therapies have been developed to reduce oxidative stress in retinal diseases, most have failed to show efficacy in clinical trials. This may be due to oversimplification of target selection for such a complex network as oxidative stress. Recent advances in high-throughput technologies have facilitated the collection of multilevel omics data, which has driven growth in public databases and in the development of bioinformatics tools. Integration of the knowledge gained from omics databases can be used to generate disease-related biological networks and to identify potential therapeutic targets within the networks. Here, we provide an overview of integrative approaches in the drug discovery process and provide simple examples of how the approaches can be exploited to identify oxidative stress-related targets for retinal diseases.

  18. Principal Ports

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Principal Ports are defined by port limits or US Army Corps of Engineers (USACE) projects, these exclude non-USACE projects not authorized for publication. The...

  19. Functional connectivity in tactile object discrimination: a principal component analysis of an event related fMRI-Study.

    Science.gov (United States)

    Hartmann, Susanne; Missimer, John H; Stoeckel, Cornelia; Abela, Eugenio; Shah, Jon; Seitz, Rüdiger J; Weder, Bruno J

    2008-01-01

    Tactile object discrimination is an essential human skill that relies on functional connectivity between the neural substrates of motor, somatosensory and supramodal areas. From a theoretical point of view, such distributed networks elude categorical analysis because subtraction methods are univariate. Thus, the aim of this study was to identify the neural networks involved in somatosensory object discrimination using a voxel-based principal component analysis (PCA) of event-related functional magnetic resonance images. Seven healthy, right-handed subjects aged between 22 and 44 years were required to discriminate with their dominant hand the length differences between otherwise identical parallelepipeds in a two-alternative forced-choice paradigm. Of the 34 principal components retained for analysis according to the 'bootstrapped' Kaiser-Guttman criterion, t-tests applied to the subject-condition expression coefficients showed significant mean differences between the object presentation and inter-stimulus phases in PC 1, 3, 26 and 32. Specifically, PC 1 reflected object exploration or manipulation, PC 3 somatosensory and short-term memory processes. PC 26 evinced the perception that certain parallelepipeds could not be distinguished, while PC 32 emerged in those choices when they could be. Among the cerebral regions evident in the PCs are the left posterior parietal lobe and premotor cortex in PC 1, the left superior parietal lobule (SPL) and the right cuneus in PC 3, the medial frontal and orbitofrontal cortex bilaterally in PC 26, and the right intraparietal sulcus, anterior SPL and dorsolateral prefrontal cortex in PC 32. The analysis provides evidence for the concerted action of large-scale cortico-subcortical networks mediating tactile object discrimination. Parallel to activity in nodes processing object-related impulses we found activity in key cerebral regions responsible for subjective assessment and validation.

  20. PKDE4J: Entity and relation extraction for public knowledge discovery.

    Science.gov (United States)

    Song, Min; Kim, Won Chul; Lee, Dahee; Heo, Go Eun; Kang, Keun Young

    2015-10-01

    Due to an enormous number of scientific publications that cannot be handled manually, there is a rising interest in text-mining techniques for automated information extraction, especially in the biomedical field. Such techniques provide effective means of information search, knowledge discovery, and hypothesis generation. Most previous studies have primarily focused on the design and performance improvement of either named entity recognition or relation extraction. In this paper, we present PKDE4J, a comprehensive text-mining system that integrates dictionary-based entity extraction and rule-based relation extraction in a highly flexible and extensible framework. Starting with the Stanford CoreNLP, we developed the system to cope with multiple types of entities and relations. The system also has fairly good performance in terms of accuracy as well as the ability to configure text-processing components. We demonstrate its competitive performance by evaluating it on many corpora and found that it surpasses existing systems with average F-measures of 85% for entity extraction and 81% for relation extraction. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Non human primate models for Alzheimer's disease-related research and drug discovery

    NARCIS (Netherlands)

    Van Dam, Debby; De Deyn, Peter Paul

    2017-01-01

    Introduction: Pathophysiological mechanisms underlying Alzheimer's disease (AD) remain insufficiently documented for the identification of accurate diagnostic markers and purposeful target discovery and development. Nonhuman primates (NHPs) have important translational value given their close

  2. Discovery and Development of Pyridine-bis(imine) and Related Catalysts for Olefin Polymerization and Oligomerization.

    Science.gov (United States)

    Small, Brooke L

    2015-09-15

    For over 40 years following the polyolefin catalyst discoveries of Hogan and Banks (Phillips) and Ziegler (Max Planck Institute), chemists traversed the periodic table searching for new transition metal and lanthanide-based olefin polymerization systems. Remarkably, none of these "hits" employed iron, that is, until three groups independently reported iron catalysts for olefin polymerization in the late 1990's. The history surrounding the discovery of these catalysts was only the beginning of their uniqueness, as the ensuing years have proven these systems remarkable in several regards. Of primary importance are the pyridine-bis(imine) ligands (herein referred to as PDI), which produced iron catalysts that are among the world's most active for ethylene polymerization, demonstrated "staying power" despite over 15 years of ligand improvement efforts, and generated highly active polymerization systems with cobalt, chromium, and vanadium. Although many ligands have been employed in iron-catalyzed polymerization, the PDI family has thus far provided the most information about iron's capabilities and tendencies. For example, iron systems tend to be highly selective for ethylene over higher olefins, making them strong candidates for producing highly crystalline polyethylene, or highly linear α-olefins. Iron PDI polymerizes propylene with 2,1-regiochemistry via a predominantly isotactic, chain end control mechanism. Because the first insertion proceeds via 1,2-regiochemistry, iron (and cobalt) PDI systems can be tailored to make highly linear dimers of α-olefins by "head-to-head" coupling, resulting from a switch in regiochemistry after the first insertion. Finally, PDI ligands, while not being surpassed in activity, have inspired the development of related ligand families and complexes, such as pendant donor diimines (PDD), which are also highly efficient at producing linear α-olefins. This Account will detail a variety of oligomerization and polymerization results

  3. ConTour: Data-Driven Exploration of Multi-Relational Datasets for Drug Discovery

    Science.gov (United States)

    Partl, Christian; Lex, Alexander; Streit, Marc; Strobelt, Hendrik; Wassermann, Anne-Mai; Pfister, Hanspeter; Schmalstieg, Dieter

    2016-01-01

    Large scale data analysis is nowadays a crucial part of drug discovery. Biologists and chemists need to quickly explore and evaluate potentially effective yet safe compounds based on many datasets that are in relationship with each other. However, there is a lack of tools that support them in these processes. To remedy this, we developed ConTour, an interactive visual analytics technique that enables the exploration of these complex, multi-relational datasets. At its core ConTour lists all items of each dataset in a column. Relationships between the columns are revealed through interaction: selecting one or multiple items in one column highlights and re-sorts the items in other columns. Filters based on relationships enable drilling down into the large data space. To identify interesting items in the first place, ConTour employs advanced sorting strategies, including strategies based on connectivity strength and uniqueness, as well as sorting based on item attributes. ConTour also introduces interactive nesting of columns, a powerful method to show the related items of a child column for each item in the parent column. Within the columns, ConTour shows rich attribute data about the items as well as information about the connection strengths to other datasets. Finally, ConTour provides a number of detail views, which can show items from multiple datasets and their associated data at the same time. We demonstrate the utility of our system in case studies conducted with a team of chemical biologists, who investigate the effects of chemical compounds on cells and need to understand the underlying mechanisms. PMID:26356902

  4. A Study of Path-Goal Relations between Leaders of College Principals and Their Subordinates in Pakistan

    Science.gov (United States)

    Awan, Riffat-un-Nisa; Zaidi, Nayyar Raza

    2009-01-01

    This study was designed to investigate the relationship among leadership behavior of degree college principals, selected organizational and personal characteristics, and faculty job satisfaction, acceptance of leader and job expectancies. The moderators included task structure, role ambiguity, stress, need for autonomy, need for achievement,…

  5. The Relation of Dropout Prevention Programs in West Virginia Schools to Dropout Rates and Principal Perceptions of Effectiveness

    Science.gov (United States)

    Cline, Vicky Callison

    2016-01-01

    This study used non-experimental survey research to gather data on the kinds of dropout prevention programs in place in West Virginia high schools in 2014-15 and to evaluate their effectiveness based on possible relationships between principals' perceptions of the programs and graduation rates. The study focused on nine of 15 effective strategies…

  6. Effects of Student Characteristics, Principal Qualifications, and Organizational Constraints for Assessing Student Achievement: A School Public Relations and Human Resources Concern

    Science.gov (United States)

    Young, I. Phillip; Vang, Maiyoua; Young, Karen Holsey

    2008-01-01

    Standards-based student achievement scores are used to assess the effectiveness of public education and to have important implications regarding school public relations and human resource practices. Often overlooked is that these scores may be moderated by the characteristics of students, the qualifications of principals, and the restraints…

  7. Teacher's Influence Scale from Their Colleagues and Principals: Its Relation with School Performance in Public Schools of the Albanian Educational System

    Science.gov (United States)

    Nathanaili, Valbona

    2016-01-01

    This article aims to evaluate the relation between school performance and the Teacher's Influence Scale on certain issues from their colleagues and principals in the public educational system of Albania. For this purpose, a questionnaire was used. The sample consisted of 428 teachers, teaching at 20 public schools in the pre-university educational…

  8. Legal Problems of the Principal.

    Science.gov (United States)

    Stern, Ralph D.; And Others

    The three talks included here treat aspects of the law--tort liability, student records, and the age of majority--as they relate to the principal. Specifically, the talk on torts deals with the consequences of principal negligence in the event of injuries to students. Assurance is given that a reasonable and prudent principal will have a minimum…

  9. Revealing Significant Relations between Chemical/Biological Features and Activity: Associative Classification Mining for Drug Discovery

    Science.gov (United States)

    Yu, Pulan

    2012-01-01

    Classification, clustering and association mining are major tasks of data mining and have been widely used for knowledge discovery. Associative classification mining, the combination of both association rule mining and classification, has emerged as an indispensable way to support decision making and scientific research. In particular, it offers a…

  10. Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-Related Metagenomes.

    Science.gov (United States)

    Popovic, Ana; Tchigvintsev, Anatoly; Tran, Hai; Chernikova, Tatyana N; Golyshina, Olga V; Yakimov, Michail M; Golyshin, Peter N; Yakunin, Alexander F

    2015-01-01

    This chapter discusses metagenomics and its application for enzyme discovery, with a focus on hydrolytic enzymes from marine metagenomic libraries. With less than one percent of culturable microorganisms in the environment, metagenomics, or the collective study of community genetics, has opened up a rich pool of uncharacterized metabolic pathways, enzymes, and adaptations. This great untapped pool of genes provides the particularly exciting potential to mine for new biochemical activities or novel enzymes with activities tailored to peculiar sets of environmental conditions. Metagenomes also represent a huge reservoir of novel enzymes for applications in biocatalysis, biofuels, and bioremediation. Here we present the results of enzyme discovery for four enzyme activities, of particular industrial or environmental interest, including esterase/lipase, glycosyl hydrolase, protease and dehalogenase.

  11. Reverse Pharmacognosy and Reverse Pharmacology; Two Closely Related Approaches for Drug Discovery Development.

    Science.gov (United States)

    Saeidnia, Soodabeh; Gohari, Ahmad R; Manayi, Azadeh

    Pharmacognosy is a science, which study natural products as a source of new drug leads and effective drug development. Rational and economic search for novel lead structures could maximize the speed of drug discovery by using powerful high technology methods. Reverse pharmacognosy, a complementary to pharmacognosy, couples the high throughput screening (HTS), virtual screening and databases along with the knowledge of traditional medicines. These strategies lead to identification of numerous in vitro active and selective hits enhancing the speed of drug discovery from natural sources. Besides, reverse pharmacology is a target base drug discovery approach; in the first step, a hypothesis is made that the alteration of specific protein activity will produce beneficial curative effects. Both, reverse pharmacognosy and reverse pharmacology take advantages of high technology methods to accomplish their particular purposes. Moreover, reverse pharmacognosy effectively utilize traditional medicines and natural products as promising sources to provide new drug leads as well as promote the rational use of them by using valuable information like protein structure databases and chemical libraries which prepare pharmacological profile of traditional medicine, plant extract or natural compounds.

  12. Principal Component Regression Analysis of the Relation Between CIELAB Color and Monomeric Anthocyanins in Young Cabernet Sauvignon Wines

    Directory of Open Access Journals (Sweden)

    Chang-Qing Duan

    2008-11-01

    Full Text Available Color is one of the key characteristics used to evaluate the sensory quality of red wine, and anthocyanins are the main contributors to color. Monomeric anthocyanins and CIELAB color values were investigated by HPLC-MS and spectrophotometry during fermentation of Cabernet Sauvignon red wine, and principal component regression (PCR, a statistical tool, was used to establish a linkage between the detected anthocyanins and wine coloring. The results showed that 14 monomeric anthocyanins could be identified in wine samples, and all of these anthocyanins were negatively correlated with the L*, b* and H*ab values, but positively correlated with a* and C*ab values. On an equal concentration basis for each detected anthocyanin, cyanidin-3-O-glucoside (Cy3-glu had the most influence on CIELAB color value, while malvidin 3-O-glucoside (Mv3-glu had the least. The color values of various monomeric anthocyanins were influenced by their structures, substituents on the B-ring, acyl groups on the glucoside and the molecular steric structure. This work develops a statistical method for evaluating correlation between wine color and monomeric anthocyanins, and also provides a basis for elucidating the effect of intramolecular copigmentation on wine coloring.

  13. A KNOWLEDGE DISCOVERY STRATEGY FOR RELATING SEA SURFACE TEMPERATURES TO FREQUENCIES OF TROPICAL STORMS AND GENERATING PREDICTIONS OF HURRICANES UNDER 21ST-CENTURY GLOBAL WARMING SCENARIOS

    Data.gov (United States)

    National Aeronautics and Space Administration — A KNOWLEDGE DISCOVERY STRATEGY FOR RELATING SEA SURFACE TEMPERATURES TO FREQUENCIES OF TROPICAL STORMS AND GENERATING PREDICTIONS OF HURRICANES UNDER 21ST-CENTURY...

  14. A Relational Database for the Discovery of Genes Encoding Amino Acid Biosynthetic Enzymes in Pathogenic Fungi

    Directory of Open Access Journals (Sweden)

    Nicholas J. Talbot

    2006-04-01

    Full Text Available Fungal phytopathogens continue to cause major economic impact, either directly, through crop losses, or due to the costs of fungicide application. Attempts to understand these organisms are hampered by a lack of fungal genome sequence data. A need exists, however, to develop specific bioinformatics tools to collate and analyse the sequence data that currently is available. A web-accessible gene discovery database (http://cogeme.ex.ac.uk/biosynthesis.html was developed as a demonstration tool for the analysis of metabolic and signal transduction pathways in pathogenic fungi using incomplete gene inventories. Using Bayesian probability to analyse the currently available gene information from pathogenic fungi, we provide evidence that the obligate pathogen Blumeria graminis possesses all amino acid biosynthetic pathways found in free-living fungi, such as Saccharomyces cerevisiae. Phylogenetic analysis was also used to deduce a gene history of succinate-semialdehyde dehydrogenase, an enzyme in the glutamate and lysine biosynthesis pathways. The database provides a tool and methodology to researchers to direct experimentation towards predicting pathway conservation in pathogenic microorganisms.

  15. Integrity, standards, and QC-related issues with big data in pre-clinical drug discovery.

    Science.gov (United States)

    Brothers, John F; Ung, Matthew; Escalante-Chong, Renan; Ross, Jermaine; Zhang, Jenny; Cha, Yoonjeong; Lysaght, Andrew; Funt, Jason; Kusko, Rebecca

    2018-03-15

    The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug discovery and development. In the field of life sciences, the growth of genetic, genomic, transcriptomic and proteomic data is partly driven by a rapid decline in experimental costs as biotechnology improves throughput, scalability, and speed. Yet far too many researchers tend to underestimate the challenges and consequences involving data integrity and quality standards. Given the effect of data integrity on scientific interpretation, these issues have significant implications during preclinical drug development. We describe standardized approaches for maximizing the utility of publicly available or privately generated biological data and address some of the common pitfalls. We also discuss the increasing interest to integrate and interpret cross-platform data. Principles outlined here should serve as a useful broad guide for existing analytical practices and pipelines and as a tool for developing additional insights into therapeutics using big data. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Hot Jupiters with relatives: discovery of additional planets in orbit around WASP-41 and WASP-47

    Science.gov (United States)

    Neveu-VanMalle, M.; Queloz, D.; Anderson, D. R.; Brown, D. J. A.; Collier Cameron, A.; Delrez, L.; Díaz, R. F.; Gillon, M.; Hellier, C.; Jehin, E.; Lister, T.; Pepe, F.; Rojo, P.; Ségransan, D.; Triaud, A. H. M. J.; Turner, O. D.; Udry, S.

    2016-02-01

    We report the discovery of two additional planetary companions to WASP-41 and WASP-47. WASP-41 c is a planet of minimum mass 3.18 ± 0.20 MJup and eccentricity 0.29 ± 0.02, and it orbits in 421 ± 2 days. WASP-47 c is a planet of minimum mass 1.24 ± 0.22 MJup and eccentricity 0.13 ± 0.10, and it orbits in 572 ± 7 days. Unlike most of the planetary systems that include a hot Jupiter, these two systems with a hot Jupiter have a long-period planet located at only ~1 au from their host star. WASP-41 is a rather young star known to be chromospherically active. To differentiate its magnetic cycle from the radial velocity effect induced by the second planet, we used the emission in the Hα line and find this indicator well suited to detecting the stellar activity pattern and the magnetic cycle. The analysis of the Rossiter-McLaughlin effect induced by WASP-41 b suggests that the planet could be misaligned, though an aligned orbit cannot be excluded. WASP-47 has recently been found to host two additional transiting super Earths. With such an unprecedented architecture, the WASP-47 system will be very important for understanding planetary migration. Using data collected at ESO's La Silla Observatory, Chile: HARPS on the ESO 3.6 m (Prog ID 087.C-0649 & 089.C-0151), the Swiss Euler Telescope, TRAPPIST, the 1.54-m Danish telescope (Prog CN2013A-159), and at the LCOGT's Faulkes Telescope South.Photometric lightcurve and RV tables are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/586/A93

  17. Discovery of Predicate-Oriented Relations among Named Entities Extracted from Thai Texts

    Science.gov (United States)

    Tongtep, Nattapong; Theeramunkong, Thanaruk

    Extracting named entities (NEs) and their relations is more difficult in Thai than in other languages due to several Thai specific characteristics, including no explicit boundaries for words, phrases and sentences; few case markers and modifier clues; high ambiguity in compound words and serial verbs; and flexible word orders. Unlike most previous works which focused on NE relations of specific actions, such as work_for, live_in, located_in, and kill, this paper proposes more general types of NE relations, called predicate-oriented relation (PoR), where an extracted action part (verb) is used as a core component to associate related named entities extracted from Thai Texts. Lacking a practical parser for the Thai language, we present three types of surface features, i.e. punctuation marks (such as token spaces), entity types and the number of entities and then apply five alternative commonly used learning schemes to investigate their performance on predicate-oriented relation extraction. The experimental results show that our approach achieves the F-measure of 97.76%, 99.19%, 95.00% and 93.50% on four different types of predicate-oriented relation (action-location, location-action, action-person and person-action) in crime-related news documents using a data set of 1,736 entity pairs. The effects of NE extraction techniques, feature sets and class unbalance on the performance of relation extraction are explored.

  18. The Discovery of First-Degree Relativity and the Refutation of Gamma

    CERN Document Server

    Mathis, M

    2000-01-01

    In pursuit of the solution to the Pioneer Anomaly, I have returned to Einstein's paper "On the Thermodynamics of Moving Bodies" (Annalen der Physik,1905)and to the book RELATIVITY (1916). I do not question the underlying theory of Special Relativity, meaning that I accept time dilation and length contraction. I assume that there must be transformation equations and that the equations of Einstein are very close to correct, due to experimental confirmation. However, in this paper I put the basic algebra under a microscope, and do a thorough analysis of Einstein's mathematical equations in both places. I show that several errors were made that subtly change the form and content of the necessary transformation equations. I show all my math, and present the corrected equations. These equations yield a tiny fractional correction to Special Relativity, and explain the greater slowing in the Pioneer Anomaly. I show, furthermore, that Einstein's equation for velocity yields two degrees of relativity. I present a veloc...

  19. A hybrid computational method for the discovery of novel reproduction-related genes.

    Science.gov (United States)

    Chen, Lei; Chu, Chen; Kong, Xiangyin; Huang, Guohua; Huang, Tao; Cai, Yu-Dong

    2015-01-01

    Uncovering the molecular mechanisms underlying reproduction is of great importance to infertility treatment and to the generation of healthy offspring. In this study, we discovered novel reproduction-related genes with a hybrid computational method, integrating three different types of method, which offered new clues for further reproduction research. This method was first executed on a weighted graph, constructed based on known protein-protein interactions, to search the shortest paths connecting any two known reproduction-related genes. Genes occurring in these paths were deemed to have a special relationship with reproduction. These newly discovered genes were filtered with a randomization test. Then, the remaining genes were further selected according to their associations with known reproduction-related genes measured by protein-protein interaction score and alignment score obtained by BLAST. The in-depth analysis of the high confidence novel reproduction genes revealed hidden mechanisms of reproduction and provided guidelines for further experimental validations.

  20. READSCAN: a fast and scalable pathogen discovery program with accurate genome relative abundance estimation.

    Science.gov (United States)

    Naeem, Raeece; Rashid, Mamoon; Pain, Arnab

    2013-02-01

    READSCAN is a highly scalable parallel program to identify non-host sequences (of potential pathogen origin) and estimate their genome relative abundance in high-throughput sequence datasets. READSCAN accurately classified human and viral sequences on a 20.1 million reads simulated dataset in Beowulf compute cluster with 16 nodes (Supplementary Material). http://cbrc.kaust.edu.sa/readscan.

  1. Sea Level Rise Data Discovery

    Science.gov (United States)

    Quach, N.; Huang, T.; Boening, C.; Gill, K. M.

    2016-12-01

    Research related to sea level rise crosses multiple disciplines from sea ice to land hydrology. The NASA Sea Level Change Portal (SLCP) is a one-stop source for current sea level change information and data, including interactive tools for accessing and viewing regional data, a virtual dashboard of sea level indicators, and ongoing updates through a suite of editorial products that include content articles, graphics, videos, and animations. The architecture behind the SLCP makes it possible to integrate web content and data relevant to sea level change that are archived across various data centers as well as new data generated by sea level change principal investigators. The Extensible Data Gateway Environment (EDGE) is incorporated into the SLCP architecture to provide a unified platform for web content and science data discovery. EDGE is a data integration platform designed to facilitate high-performance geospatial data discovery and access with the ability to support multi-metadata standard specifications. EDGE has the capability to retrieve data from one or more sources and package the resulting sets into a single response to the requestor. With this unified endpoint, the Data Analysis Tool that is available on the SLCP can retrieve dataset and granule level metadata as well as perform geospatial search on the data. This talk focuses on the architecture that makes it possible to seamlessly integrate and enable discovery of disparate data relevant to sea level rise.

  2. Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases

    OpenAIRE

    Nishimura, Yuhei; Hara, Hideaki

    2016-01-01

    Excessive oxidative stress induces dysregulation of functional networks in the retina, resulting in retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Although various therapies have been developed to reduce oxidative stress in retinal diseases, most have failed to show efficacy in clinical trials. This may be due to oversimplification of target selection for such a complex network as oxidative stress. Recent advances in high-throughput technologies...

  3. Literature-based discovery of diabetes- and ROS-related targets

    Directory of Open Access Journals (Sweden)

    Pande Manjusha

    2010-10-01

    Full Text Available Abstract Background Reactive oxygen species (ROS are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS. Methods We present ROS- and diabetes-related targets (genes/proteins collected from the biomedical literature through a text mining technology. A web-based literature mining tool, SciMiner, was applied to 1,154 biomedical papers indexed with diabetes and ROS by PubMed to identify relevant targets. Over-represented targets in the ROS-diabetes literature were obtained through comparisons against randomly selected literature. The expression levels of nine genes, selected from the top ranked ROS-diabetes set, were measured in the dorsal root ganglia (DRG of diabetic and non-diabetic DBA/2J mice in order to evaluate the biological relevance of literature-derived targets in the pathogenesis of diabetic neuropathy. Results SciMiner identified 1,026 ROS- and diabetes-related targets from the 1,154 biomedical papers (http://jdrf.neurology.med.umich.edu/ROSDiabetes/. Fifty-three targets were significantly over-represented in the ROS-diabetes literature compared to randomly selected literature. These over-represented targets included well-known members of the oxidative stress response including catalase, the NADPH oxidase family, and the superoxide dismutase family of proteins. Eight of the nine selected genes exhibited significant differential expression between diabetic and non-diabetic mice. For six genes, the direction of expression change in diabetes paralleled enhanced oxidative stress in the DRG. Conclusions Literature mining compiled ROS-diabetes related targets from the biomedical literature and led us to evaluate the biological relevance of selected targets in the pathogenesis of diabetic neuropathy.

  4. Discovery of a novel hepatovirus (Phopivirus of seals) related to human Hepatitis A Virus

    Science.gov (United States)

    Anthony. S.J.,; St. Leger, J.A; Liang, E.; Hicks, A.L.; Sanchez-Leon, M.D; Ip, Hon S.; Jain, K.; Lefkowitch, J. H.; Navarrete-Macias, I.; Knowles, N.; Goldstein, T.; Pugliares, K.; Rowles, T.; Lipkin, W.I.

    2015-01-01

    Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV.

  5. READSCAN: A fast and scalable pathogen discovery program with accurate genome relative abundance estimation

    KAUST Repository

    Naeem, Raeece

    2012-11-28

    Summary: READSCAN is a highly scalable parallel program to identify non-host sequences (of potential pathogen origin) and estimate their genome relative abundance in high-throughput sequence datasets. READSCAN accurately classified human and viral sequences on a 20.1 million reads simulated dataset in <27 min using a small Beowulf compute cluster with 16 nodes (Supplementary Material). Availability: http://cbrc.kaust.edu.sa/readscan Contact: or raeece.naeem@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online. 2012 The Author(s).

  6. Discovery of porcine maternal factors related to nuclear reprogramming and early embryo development by proteomic analysis.

    Science.gov (United States)

    Zhao, Qi; Guo, Zheng; Piao, Shanhua; Wang, Chunsheng; An, Tiezhu

    2015-01-01

    Differentiated cell nuclei can be reprogrammed to a pluripotent state in several ways, including incubation with oocyte extracts, transfer into enucleated oocytes, and induced pluripotent stem cell technology. Nuclear transfer-mediated reprogramming has been proven to be the most efficient method. Maternal factors stored in oocytes have critical roles on nuclear reprogramming and early embryo development, but remain elusive. In this study, we showed most of porcine oocytes became nuclear matured at 33 h of IVM and the rate had no significant difference with oocytes at 42 h of IVM (p > 0.05). Moreover, the cleavage and blastocyst rates of SCNT and PA embryos derived from 42O were significantly higher than that of 33O (p embryo development with higher cleavage and blastocyst rates comparing to 42O (p development potential difference between 33O and 42O, 18 differentially expressed proteins were identified by proteomic analysis, and randomly selected proteins were confirmed by Western blot. Bioinformatic analysis of these proteins revealed that 33O highly synthesized proteins related to fertilization, and 42O was rich in nuclear reprogramming factors. These results present a unique insight into maternal factors related to nuclear reprogramming and early embryo development.

  7. Some aerodynamic discoveries and related NACA/NASA research programs following World War 2

    Science.gov (United States)

    Spearman, M. L.

    1984-01-01

    The World War 2 time period ushered in a new era in aeronautical research and development. The air conflict during the war highlighted the need of aircraft with agility, high speed, long range, large payload capability, and in addition, introduced a new concept in air warfare through the use of guided missiles. Following the war, the influx of foreign technology, primarily German, led to rapid advances in jet propulsion and speed, and a host of new problem areas associated with high-speed flight designs were revealed. The resolution of these problems led to a rash of new design concepts and many of the lessons learned, in principle, are still effective today. In addition to the technical lessons learned related to aircraft development programs, it might also be noted that some lessons involving the political and philosophical nature of aircraft development programs are worth attention.

  8. Knowledge discovery in ophthalmology: analysis of wet form of age-related macular degeneration treatment outcomes

    Science.gov (United States)

    Ulińska, Magdalena; Tataj, Emanuel; Mulawka, Jan J.; Szaflik, Jerzy

    2009-06-01

    Age-related Macular Degeneration (AMD), according to epidemiological data, is a main reason of social blindness among elderly people in developed countries. There are two forms of AMD: dry and wet. The first one is of good prognosis with low possibility of serious visual deterioration, while the second one usually leads to quick and severe visual impairment. The aim of our investigations is to analyse results of so called real-life treatment of wet AMD. We analysed outcomes of our patients treated with intravitreal injections of anti-VEGF drugs: Lucentis (61 patients) and Avastin (78 patients). We analysed changes in visual acuity (functional effect) and central retinal thickness (anatomic effect). Both drugs occurred to be efficient in treatment of wet form of AMD, however results were more satisfying in patients with better baseline visual acuity. In our approach we used R environment - an integrated suite of software facilities for data analysis and graphics.

  9. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    The price discovery literature investigates how homogenous securities traded on different markets incorporate information into prices. We take this literature one step further and investigate how these markets contribute to stochastic volatility (volatility discovery). We formally show...... that the realized measures from homogenous securities share a fractional stochastic trend, which is a combination of the price and volatility discovery measures. Furthermore, we show that volatility discovery is associated with the way that market participants process information arrival (market sensitivity......). Finally, we compute volatility discovery for 30 actively traded stocks in the U.S. and report that Nyse and Arca dominate Nasdaq....

  10. Transcriptomics Analysis of Crassostrea hongkongensis for the Discovery of Reproduction-Related Genes.

    Directory of Open Access Journals (Sweden)

    Ying Tong

    Full Text Available The reproductive mechanisms of mollusk species have been interesting targets in biological research because of the diverse reproductive strategies observed in this phylum. These species have also been studied for the development of fishery technologies in molluscan aquaculture. Although the molecular mechanisms underlying the reproductive process have been well studied in animal models, the relevant information from mollusks remains limited, particularly in species of great commercial interest. Crassostrea hongkongensis is the dominant oyster species that is distributed along the coast of the South China Sea and little genomic information on this species is available. Currently, high-throughput sequencing techniques have been widely used for investigating the basis of physiological processes and facilitating the establishment of adequate genetic selection programs.The C.hongkongensis transcriptome included a total of 1,595,855 reads, which were generated by 454 sequencing and were assembled into 41,472 contigs using de novo methods. Contigs were clustered into 33,920 isotigs and further grouped into 22,829 isogroups. Approximately 77.6% of the isogroups were successfully annotated by the Nr database. More than 1,910 genes were identified as being related to reproduction. Some key genes involved in germline development, sex determination and differentiation were identified for the first time in C.hongkongensis (nanos, piwi, ATRX, FoxL2, β-catenin, etc.. Gene expression analysis indicated that vasa, nanos, piwi, ATRX, FoxL2, β-catenin and SRD5A1 were highly or specifically expressed in C.hongkongensis gonads. Additionally, 94,056 single nucleotide polymorphisms (SNPs and 1,699 simple sequence repeats (SSRs were compiled.Our study significantly increased C.hongkongensis genomic information based on transcriptomics analysis. The group of reproduction-related genes identified in the present study constitutes a new tool for research on bivalve

  11. Hybrid Multidimensional Relational and Link Analytical Knowledge Discovery for Law Enforcement

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, Cliff A.; Gillen, David S.; Burke, John S.; Critchlow, Terence J.; Damante, Matt; Fernandes, Robert

    2008-08-01

    The challenges facing the Department of Homeland Security (DHS) require not only multi-dimensional, but also multi-scale data analysis. In particular, the ability to seamlessly move from summary information, such as trends, into detailed analysis of individual entities, while critical for law enforcement, typically requires manually transferring information among multiple tools. Such time-consuming and error prone processes significantly hamper the analysts' ability to quickly explore data and identify threats. As part of a DHS Science and Technology effort, we have been developing and deploying for Immigration and Customs Enforcement the CubeLink system integrating information between relational data cubes and link analytical semantic graphs. In this paper we describe CubeLink in terms of the underlying components, their integration, and the formal mapping from multidimensional data analysis into link analysis. In so doing, we provide a formal basis for one particular form of automatic schema-ontology mapping from OLAP data cubes to semantic graphs databases, and point the way towards future ``intelligent'' OLAP data cubes equipped with meta-data about their dimensional typing.

  12. Discovery, Biosynthesis and Stress-Related Accumulation of Dolabradiene-Derived Defenses in Maize.

    Science.gov (United States)

    Mafu, Sibongile; Ding, Yezhang; Murphy, Katherine M; Yaacoobi, Omar; Addison, J Bennett; Wang, Qiang; Shen, Zhouxin; Briggs, Steven P; Bohlmann, Jörg; Castro-Falcon, Gabriel; Hughes, Chambers C; Betsiashvili, Mariam; Huffaker, Alisa; Schmelz, Eric A; Zerbe, Philipp

    2018-04-01

    Terpenoids are a major component of maize ( Zea mays ) chemical defenses that mediate responses to herbivores, pathogens, and other environmental challenges. Here, we describe the biosynthesis and elicited production of a class of maize diterpenoids, named dolabralexins. Dolabralexin biosynthesis involves the sequential activity of two diterpene synthases, ENT -COPALYL DIPHOSPHATE SYNTHASE (ZmAN2) and KAURENE SYNTHASE-LIKE4 (ZmKSL4). Together, ZmAN2 and ZmKSL4 form the diterpene hydrocarbon dolabradiene. In addition, we biochemically characterized a cytochrome P450 monooxygenase, ZmCYP71Z16, which catalyzes the oxygenation of dolabradiene to yield the epoxides 15,16-epoxydolabrene (epoxydolabrene) and 3β-hydroxy-15,16-epoxydolabrene (epoxydolabranol). The absence of dolabradiene and epoxydolabranol in Zman2 mutants under elicited conditions confirmed the in vivo biosynthetic requirement of ZmAN2. Combined mass spectrometry and NMR experiments demonstrated that much of the epoxydolabranol is further converted into 3β,15,16-trihydroxydolabrene (trihydroxydolabrene). Metabolite profiling of field-grown maize root tissues indicated that dolabralexin biosynthesis is widespread across common maize cultivars, with trihydroxydolabrene as the predominant diterpenoid. Oxidative stress induced dolabralexin accumulation and transcript expression of ZmAN2 and ZmKSL4 in root tissues, and metabolite and transcript accumulation were up-regulated in response to elicitation with the fungal pathogens Fusarium verticillioides and Fusarium graminearum Consistently, epoxydolabranol significantly inhibited the growth of both pathogens in vitro at 10 µg mL -1 , while trihydroxydolabrene-mediated inhibition was specific to F verticillioides These findings suggest that dolabralexins have defense-related roles in maize stress interactions and expand the known chemical space of diterpenoid defenses as genetic targets for understanding and ultimately improving maize resilience. © 2018

  13. Computer Aided Drug Design Studies in the Discovery of Secondary Metabolites Targeted Against Age-Related Neurodegenerative Diseases.

    Science.gov (United States)

    Scotti, Luciana; Scotti, Marcus Tullius

    2015-01-01

    Secondary metabolites are plant products that occur usually in differentiated cells, generally not being necessary for the cells themselves, but likely useful for the plant as a whole. Neurodegeneration can be found in many different levels in the neurons, it always begins at the molecular level and progresses toward the systemic levels. Usually, alterations are observed such as decreasing cholinergic impulse, toxicity related to reactive oxygen species (ROS, inflammatory "amyloid plaque" related processes, catecholamine disequilibrium, etc. Computer aided drug design (CADD has become relevant in the drug discovery process; technological advances in the areas of molecular structure characterization, computational science, and molecular biology have contributed to the planning of new drugs against neurodegenerative diseases. This review discusses scientific CADD studies of the secondary metabolites. Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. In addition, we have applied ligand-based-virtual screening (using Random Forest, associated with structure-based- virtual screening (docking of a small dataset of 469 alkaloids of the Apocynaceae family from an in-house data bank to select structures with potential inhibitory activity against human AChE. This computer-aided drug design study selected certain alkaloids that might be useful in further studies for the treatment of neurological disorders such as Alzheimer's and Parkinson's disease.

  14. Russian Chronicles on the Religious Policy of Uzbek Khan (1313–1341 and His Relations with the Principalities of the North-Eastern Rus’.

    Directory of Open Access Journals (Sweden)

    Hautala R.

    2017-12-01

    Full Text Available Research objectives: The author of present article examines the overall response of Russian medieval scribes to the ascension to power of Uzbek Khan – the Golden Horde’s Muslim ruler who made a major effort to spread Islam in the Jochid Empire. Analyzing Russian sources, the author tries to answer the question regarding to what extent we can trust the reliability of their information about the impact of Uzbek’s religious affiliation on the anticipated change in his relations with the Russian principalities. Research materials: Russian sources are of paramount importance for the study of the Golden Horde’s history. On the one hand, Russian chronicles contain a wealth of relevant factual material. The abundance of this material can be explained by the fact that medieval Rus’ was subordinated to the Golden Horde, although its numerous and disjointed princes enjoyed considerable autonomy within the Jochid Empire. On the other hand, the accuracy of Russian chronicles’ information should not be overestimated for several reasons. The preserved chronicle collections were often composed several centuries after the described events. Therefore, their information underwent the influence of significant ideological changes. In addition, the authors of Russian chronicles focused on the description of only those events that were directly related to the Russian principalities and their rulers. The novelty of this study emerges from a comparison of the Russian chronicles’ content with information found in little-known written sources. In particular, Latin sources compiled within the ulus of Jochi in a relatively large amount exactly during the period under study compensate to some extent for the complete absence of Jochid written sources. In this case, the content of the Latin sources will allow us to reconsider the established opinion about the total Islamization of the ulus of Jochi during Uzbek’s reign. Research results: The use of

  15. Principal component analysis

    NARCIS (Netherlands)

    Bro, R.; Smilde, A.K.

    2014-01-01

    Principal component analysis is one of the most important and powerful methods in chemometrics as well as in a wealth of other areas. This paper provides a description of how to understand, use, and interpret principal component analysis. The paper focuses on the use of principal component analysis

  16. Preventing work-related stress among staff working in children's cancer Principal Treatment Centres in the UK: a brief survey of staff support systems and practices.

    Science.gov (United States)

    Beresford, B; Gibson, F; Bayliss, J; Mukherjee, S

    2018-03-01

    Growing evidence of the association between health professionals' well-being and patient and organisational outcomes points to the need for effective staff support. This paper reports a brief survey of the UK's children's cancer Principal Treatment Centres (PTCs) regarding staff support systems and practices. A short on-line questionnaire, administered in 2012-2013, collected information about the availability of staff support interventions which seek to prevent work-related stress among different members of the multi-disciplinary team (MDT). It was completed by a member of staff with, where required, assistance from colleagues. All PTCs (n = 19) participated. Debriefs following a patient death was the most frequently reported staff support practice. Support groups were infrequently mentioned. There was wide variability between PTCs, and between professional groups, regarding the number and type of interventions available. Doctors appear to be least likely to have access to support. A few Centres routinely addressed work-related stress in wider staff management strategies. Two Centres had developed a bespoke intervention. Very few Centres were reported to actively raise awareness of support available from their hospital's Occupational Health department. A minority of PTCs had expert input regarding staff support from clinical psychology/liaison psychiatry. © 2016 The Authors. European Journal of Cancer Care Published by John Wiley & Sons Ltd.

  17. Principal-Counselor Collaboration and School Climate

    Science.gov (United States)

    Rock, Wendy D.; Remley, Theodore P.; Range, Lillian M.

    2017-01-01

    Examining whether principal-counselor collaboration and school climate were related, researchers sent 4,193 surveys to high school counselors in the United States and received 419 responses. As principal-counselor collaboration increased, there were increases in counselors viewing the principal as supportive, the teachers as regarding one another…

  18. Pharmacogenetics Meets Metabolomics: Discovery of Tryptophan as a New Endogenous OCT2 Substrate Related to Metformin Disposition

    Science.gov (United States)

    Shin, Min-Hye; Kim, Hyunmi; Ahn, Yun Gyong; Park, Inmyoung; Kim, Kyoung Heon; Kind, Tobias; Shin, Jae-Gook; Fiehn, Oliver; Liu, Kwang-Hyeon

    2012-01-01

    Genetic polymorphisms of the organic cation transporter 2 (OCT2), encoded by SLC22A2, have been investigated in association with metformin disposition. A functional decrease in transport function has been shown to be associated with the OCT2 variants. Using metabolomics, our study aims at a comprehensive monitoring of primary metabolite changes in order to understand biochemical alteration associated with OCT2 polymorphisms and discovery of potential endogenous metabolites related to the genetic variation of OCT2. Using GC-TOF MS based metabolite profiling, clear clustering of samples was observed in Partial Least Square Discriminant Analysis, showing that metabolic profiles were linked to the genetic variants of OCT2. Tryptophan and uridine presented the most significant alteration in SLC22A2-808TT homozygous and the SLC22A2-808G>T heterozygous variants relative to the reference. Particularly tryptophan showed gene-dose effects of transporter activity according to OCT2 genotypes and the greatest linear association with the pharmacokinetic parameters (Clrenal, Clsec, Cl/F/kg, and Vd/F/kg) of metformin. An inhibition assay demonstrated the inhibitory effect of tryptophan on the uptake of 1-methyl-4-phenyl pyrinidium in a concentration dependent manner and subsequent uptake experiment revealed differential tryptophan-uptake rate in the oocytes expressing OCT2 reference and variant (808G>T). Our results collectively indicate tryptophan can serve as one of the endogenous substrate for the OCT2 as well as a biomarker candidate indicating the variability of the transport activity of OCT2. PMID:22590580

  19. Endogenously synthesized (-)-proto-quercitol and glycine betaine are principal compatible solutes of Schizochytrium sp. strain S8 (ATCC 20889) and three new isolates of phylogenetically related thraustochytrids.

    Science.gov (United States)

    Jakobsen, Anita N; Aasen, Inga M; Strøm, Arne R

    2007-09-01

    We report that endogenously synthesized (-)-proto-quercitol (1D-1,3,4/2,5-cyclohexanepentol) and glycine betaine were the principal compatible solutes of Schizochytrium sp. strain S8 (ATCC 20889) and three new osmotolerant isolates of thraustochytrids (strains T65, T66, and T67). The compatible solutes were identified and quantified by use of nuclear magnetic resonance spectroscopy, and their identity was confirmed by mass spectroscopy and measurement of the specific optical rotation. The cellular content of compatible solutes increased with increasing NaCl concentration of a defined medium. (-)-proto-Quercitol was the dominating solute at all NaCl concentrations tested (0.25 to 1.0 M), e.g., cells of S8 and T66 stressed with 1.0 M NaCl accumulated about 500 micromol (-)-proto-quercitol and 100 micromol glycine betaine per g dry weight. To our knowledge, (-)-proto-quercitol has previously been found only in eucalyptus. The 18S rRNA gene sequences of the four (-)-proto-quercitol-producing strains showed 99% identity, and they displayed the same fatty acid profile. The only polyunsaturated fatty acids accumulated were docosahexaenoic acid (78%) and docosapentaenoic acid (22%). A less osmotolerant isolate (strain T29), which was closely phylogenetically related to Thraustochytrium aureum (ATCC 34304), did not contain (-)-proto-quercitol or glycine betaine. Thus, the level of osmotolerance and the osmolyte systems vary among thraustochytrids.

  20. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2017-01-01

    In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well as the...

  1. Redesigning Principal Internships: Practicing Principals' Perspectives

    Science.gov (United States)

    Anast-May, Linda; Buckner, Barbara; Geer, Gregory

    2011-01-01

    Internship programs too often do not provide the types of experiences that effectively bridge the gap between theory and practice and prepare school leaders who are capable of leading and transforming schools. To help address this problem, the current study is directed at providing insight into practicing principals' views of the types of…

  2. Principal Ports and Facilities

    Data.gov (United States)

    California Natural Resource Agency — The Principal Port file contains USACE port codes, geographic locations (longitude, latitude), names, and commodity tonnage summaries (total tons, domestic, foreign,...

  3. Principal Ports and Facilities

    Data.gov (United States)

    California Department of Resources — The Principal Port file contains USACE port codes, geographic locations (longitude, latitude), names, and commodity tonnage summaries (total tons, domestic, foreign,...

  4. An Investigation of the Micro-Electrical Discharge Machining of Nickel-Titanium Shape Memory Alloy Using Grey Relations Coupled with Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Mustufa Haider Abidi

    2017-11-01

    Full Text Available Shape memory alloys (SMAs are advanced engineering materials which possess shape memory effects and super-elastic properties. Their high strength, high wear-resistance, pseudo plasticity, etc., makes the machining of Ni-Ti based SMAs difficult using traditional techniques. Among all non-conventional processes, micro-electric discharge machining (micro-EDM is considered one of the leading processes for micro-machining, owing to its high aspect ratio and capability to machine hard-to-cut materials with good surface finish.The selection of the most appropriate input parameter combination to provide the optimum values for various responses is very important in micro-EDM. This article demonstrates the methodology for optimizing multiple quality characteristics (overcut, taper angle and surface roughness to enhance the quality of micro-holes in Ni-Ti based alloy, using the Grey–Taguchi method. A Taguchi-based grey relational analysis coupled with principal component analysis (Grey-PCA methodology was implemented to investigate the effect of three important micro-EDM process parameters, namely capacitance, voltage and electrode material.The analysis of the individual responses established the importance of multi-response optimization. The main effects plots for the micro-EDM parameters and Analysis of Variance (ANOVA indicate that every parameter does not produce same effect on individual responses, and also that the percent contribution of each parameter to individual response is highly varied. As a result, multi-response optimization was implemented using Grey-PCA. Further, this study revealed that the electrode material had the strongest effect on the multi-response parameter, followed by the voltage and capacitance. The main effects plot for the Grey-PCA shows that the micro-EDM parameters “capacitance” at level-2 (i.e., 475 pF, “discharge voltage” at level-1 (i.e., 80 V and the “electrode material” Cu provided the best multi-response.

  5. Principal minors and rhombus tilings

    International Nuclear Information System (INIS)

    Kenyon, Richard; Pemantle, Robin

    2014-01-01

    The algebraic relations between the principal minors of a generic n × n matrix are somewhat mysterious, see e.g. Lin and Sturmfels (2009 J. Algebra 322 4121–31). We show, however, that by adding in certain almost principal minors, the ideal of relations is generated by translations of a single relation, the so-called hexahedron relation, which is a composition of six cluster mutations. We give in particular a Laurent-polynomial parameterization of the space of n × n matrices, whose parameters consist of certain principal and almost principal minors. The parameters naturally live on vertices and faces of the tiles in a rhombus tiling of a convex 2n-gon. A matrix is associated to an equivalence class of tilings, all related to each other by Yang–Baxter-like transformations. By specializing the initial data we can similarly parameterize the space of Hermitian symmetric matrices over R,C or H the quaternions. Moreover by further specialization we can parametrize the space of positive definite matrices over these rings. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Cluster algebras mathematical physics’. (paper)

  6. Principals as Instructional Leaders

    Science.gov (United States)

    Finkel, Ed

    2012-01-01

    At some level, principals always have been instructional leaders--but never before has their role been more prominent. First, the accountability movement--No Child Left Behind (NCLB) in particular--thrust principals into the spotlight on academic achievement. Then budget cuts peeled away capacity at both the district and school levels, thinning…

  7. Principal Preparation Programs

    Science.gov (United States)

    Butler, Kevin

    2008-01-01

    A school principal's job has never been tougher. The accountability movement--culminating with the federal No Child Left Behind law in 2001--has put pressure on principals to improve student performance, resulting in school leaders' transitioning from a more administrative role to becoming more heavily involved in assessment, instruction,…

  8. Principals' Perceptions of Politics

    Science.gov (United States)

    Tooms, Autumn K.; Kretovics, Mark A.; Smialek, Charles A.

    2007-01-01

    This study is an effort to examine principals' perceptions of workplace politics and its influence on their productivity and efficacy. A survey was used to explore the perceptions of current school administrators with regard to workplace politics. The instrument was disseminated to principals serving public schools in one Midwestern state in the…

  9. Qualities of Effective Principals

    Science.gov (United States)

    Stronge, James H.; Richard, Holly B.; Catano, Nancy

    2008-01-01

    You know how important principals are in advancing student achievement and school success, but it's not been exactly clear which components of the principal's job are the highest priority... until now. Following on the results-based approach from the ASCD best-seller "Qualities of Effective Teachers", James Stronge and his coauthors…

  10. Principal bundles the classical case

    CERN Document Server

    Sontz, Stephen Bruce

    2015-01-01

    This introductory graduate level text provides a relatively quick path to a special topic in classical differential geometry: principal bundles.  While the topic of principal bundles in differential geometry has become classic, even standard, material in the modern graduate mathematics curriculum, the unique approach taken in this text presents the material in a way that is intuitive for both students of mathematics and of physics. The goal of this book is to present important, modern geometric ideas in a form readily accessible to students and researchers in both the physics and mathematics communities, providing each with an understanding and appreciation of the language and ideas of the other.

  11. Developing doctoral scientists for drug discovery: pluridimensional education required.

    Science.gov (United States)

    Janero, David R

    2013-02-01

    Research universities continue to produce new scientists capable of generating knowledge with the potential to inform disease etiology and treatment. Mounting interest of doctoral-level experimental science students in therapeutics-related research careers is discordant with the widespread lack of direct drug-discovery and development experience, let alone commercialization success, among university faculty and administrators. Likewise, the archetypical publication- and grant-fueled, principal investigator (PI)-focused academic system ("PI-stan") risks commoditization of science students pursuing their doctorates as a labor source, rendering them ill-prepared for career options related to therapeutics innovation by marginalizing their development of "beyond-the-bench" professional skills foundational to modern drug-discovery campaigns and career fluency. To militate against professionalization deficits in doctoral drug-discovery researchers, the author--a scientist-administrator-consultant with decades of discovery research and development (R&D), business, and educator experience in commercial and university settings--posits a critical need for pluridimensionality in graduate education and mentorship that extends well beyond thesis-related scientific domains/laboratory techniques to instill transferable operational-intelligence, project/people-management, and communication competencies. Specific initiatives are advocated to help enhance the doctoral science student's market competitiveness, adaptability, and navigation of the significant research, commercial, and occupational challenges associated with contemporary preclinical drug-discovery R&D.

  12. Multiscale principal component analysis

    International Nuclear Information System (INIS)

    Akinduko, A A; Gorban, A N

    2014-01-01

    Principal component analysis (PCA) is an important tool in exploring data. The conventional approach to PCA leads to a solution which favours the structures with large variances. This is sensitive to outliers and could obfuscate interesting underlying structures. One of the equivalent definitions of PCA is that it seeks the subspaces that maximize the sum of squared pairwise distances between data projections. This definition opens up more flexibility in the analysis of principal components which is useful in enhancing PCA. In this paper we introduce scales into PCA by maximizing only the sum of pairwise distances between projections for pairs of datapoints with distances within a chosen interval of values [l,u]. The resulting principal component decompositions in Multiscale PCA depend on point (l,u) on the plane and for each point we define projectors onto principal components. Cluster analysis of these projectors reveals the structures in the data at various scales. Each structure is described by the eigenvectors at the medoid point of the cluster which represent the structure. We also use the distortion of projections as a criterion for choosing an appropriate scale especially for data with outliers. This method was tested on both artificial distribution of data and real data. For data with multiscale structures, the method was able to reveal the different structures of the data and also to reduce the effect of outliers in the principal component analysis

  13. An in vivo-like tumor stem cell-related glioblastoma in vitro model for drug discovery

    DEFF Research Database (Denmark)

    Jensen, Stine Skov; Aaberg-Jessen, Charlotte; Nørregaard, Annette

    the effects of new drugs on tumor cells including tumor stem cells. Implantation of glioblastoma cells into organotypic brain slice cultures has previously been published as a model system, but not using a stem cell favourable environment. Organotypic corticostriatal rat brain slice cultures were prepared...... and cultured in a serum containing medium replaced after three days with a serum-free stem cell medium. Thereafter fluorescent DiI labelled glioblastoma spheroids from the cell line U87 and the tumor stem cell line SJ-1 established in our laboratory were implanted into the brain slices between cortex......The discovery of tumor stem cells being highly resistant against therapy makes new demands to model systems suitable for evaluation of the effects of new drugs on tumor stem cells. The aim of the present study was therefore to develop an in vivo-like in vitro glioblastoma model for testing...

  14. Euler principal component analysis

    NARCIS (Netherlands)

    Liwicki, Stephan; Tzimiropoulos, Georgios; Zafeiriou, Stefanos; Pantic, Maja

    Principal Component Analysis (PCA) is perhaps the most prominent learning tool for dimensionality reduction in pattern recognition and computer vision. However, the ℓ 2-norm employed by standard PCA is not robust to outliers. In this paper, we propose a kernel PCA method for fast and robust PCA,

  15. The Principal as CEO

    Science.gov (United States)

    Hollar, Charlie

    2004-01-01

    They may never grace the pages of The Wall Street Journal or Fortune magazine, but they might possibly be the most important CEOs in our country. They are elementary school principals. Each of them typically serves the learning needs of 350-400 clients (students) while overseeing a multimillion-dollar facility staffed by 20-25 teachers and 10-15…

  16. Strategic Principal Communication

    Science.gov (United States)

    Henry, Jake; Woody, Aaron

    2013-01-01

    As communities become increasingly diverse and criticism of traditional public schools intensifies, some states, such as North Carolina, have enacted legislation that encourages alternative forms of schooling. This condition has resulted in new challenges for principals to communicate broadly and often with stakeholders in an effort to build…

  17. Negligence--When Is the Principal Liable? A Legal Memorandum.

    Science.gov (United States)

    Stern, Ralph D., Ed.

    Negligence, a tort liability, is defined, discussed, and reviewed in relation to several court decisions involving school principals. The history of liability suits against school principals suggests that a reasonable, prudent principal can avoid legal problems. Ten guidelines are presented to assist principals in avoiding charges of negligence.…

  18. Data Discovery

    Directory of Open Access Journals (Sweden)

    Gerhard Weikum

    2013-07-01

    Full Text Available Discovery of documents, data sources, facts, and opinions is at the very heart of digital information and knowledge services. Being able to search, discover, compile, and analyse relevant information for a user’s specific tasks is of utmost importance in science (e.g., computational life sciences, digital humanities, etc., business (e.g., market and media analytics, customer relationship management, etc. , and society at large (e.g., consumer information, traffic logistics, health discussions, etc..

  19. Cosmic Discovery

    Science.gov (United States)

    Harwit, Martin

    1984-04-01

    In the remarkable opening section of this book, a well-known Cornell astronomer gives precise thumbnail histories of the 43 basic cosmic discoveries - stars, planets, novae, pulsars, comets, gamma-ray bursts, and the like - that form the core of our knowledge of the universe. Many of them, he points out, were made accidentally and outside the mainstream of astronomical research and funding. This observation leads him to speculate on how many more major phenomena there might be and how they might be most effectively sought out in afield now dominated by large instruments and complex investigative modes and observational conditions. The book also examines discovery in terms of its political, financial, and sociological context - the role of new technologies and of industry and the military in revealing new knowledge; and methods of funding, of peer review, and of allotting time on our largest telescopes. It concludes with specific recommendations for organizing astronomy in ways that will best lead to the discovery of the many - at least sixty - phenomena that Harwit estimates are still waiting to be found.

  20. Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.

    Science.gov (United States)

    Filosa, Rosanna; Peduto, Antonella; Aparoy, Polamarasetty; Schaible, Anja M; Luderer, Susann; Krauth, Verena; Petronzi, Carmen; Massa, Antonio; de Rosa, Mario; Reddanna, Pallu; Werz, Oliver

    2013-09-01

    5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and allergic diseases. Here, we present the discovery and biological evaluation of novel series of 1,4-benzoquinones and respective resorcinol derivatives that efficiently inhibit human 5-LO, with little effects on other human lipoxygenases. SAR analysis revealed that the potency of the compounds strongly depends on structural features of the lipophilic residues, where bulky naphthyl or dibenzofuran moieties favor 5-LO inhibition. Among the 1,4-benzoquinones, compound Ig 5-[(2-naphthyl)methyl]-2-hydroxy-2,5-cyclohexadiene-1,4-dione potently blocked 5-LO activity in cell-free assays with IC50 = 0.78 μM, and suppressed 5-LO product synthesis in polymorphonuclear leukocytes with IC50 = 2.3 μM. Molecular docking studies suggest a concrete binding site for Ig in 5-LO where select π-π interactions along with hydrogen bond interactions accomplish binding to the active site of the enzyme. Together, our study reveals novel valuable 5-LO inhibitors with potential for further preclinical assessment as anti-inflammatory compounds. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  1. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    2015-08-28

    Aug 28, 2015 ... Of the about 3000 isotopes presently known, about 20% have been discovered in fission. The history of fission as it relates to the discovery of isotopes as well as the various reaction mechanisms leading to isotope discoveries involving fission are presented.

  2. Check List: Are You a Gifted Principal?

    Science.gov (United States)

    Taylor, Vicki L.

    1984-01-01

    An 18-item check list is provided for principals to evaluate themselves relative to encouraging gifts and talents of their most able students. Suggestions are given in the areas of educational needs, specialized materials, and counseling. (MC)

  3. Spatial control of groundwater contamination, using principal ...

    Indian Academy of Sciences (India)

    ; indexed wells; river basin; ... contamination. The numerical values of principal component (PC) loadings and scores are used (i) to interpret the relative importance of the chemi- ...... Berner E K and Berner R A 1987 The global water cycle ...

  4. Discovery Mondays

    CERN Multimedia

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  5. Semantics in support of biodiversity knowledge discovery: an introduction to the biological collections ontology and related ontologies.

    Science.gov (United States)

    Walls, Ramona L; Deck, John; Guralnick, Robert; Baskauf, Steve; Beaman, Reed; Blum, Stanley; Bowers, Shawn; Buttigieg, Pier Luigi; Davies, Neil; Endresen, Dag; Gandolfo, Maria Alejandra; Hanner, Robert; Janning, Alyssa; Krishtalka, Leonard; Matsunaga, Andréa; Midford, Peter; Morrison, Norman; Ó Tuama, Éamonn; Schildhauer, Mark; Smith, Barry; Stucky, Brian J; Thomer, Andrea; Wieczorek, John; Whitacre, Jamie; Wooley, John

    2014-01-01

    The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open Biological and Biomedical Ontologies (OBO) Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques), as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1) individual organisms, including voucher specimens from ecological studies and museum specimens, 2) bulk or environmental samples (e.g., gut contents, soil, water) that include DNA, other molecules, and potentially many organisms, especially microbes, and 3) survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and researchers.

  6. Semantics in support of biodiversity knowledge discovery: an introduction to the biological collections ontology and related ontologies.

    Directory of Open Access Journals (Sweden)

    Ramona L Walls

    Full Text Available The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open Biological and Biomedical Ontologies (OBO Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques, as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1 individual organisms, including voucher specimens from ecological studies and museum specimens, 2 bulk or environmental samples (e.g., gut contents, soil, water that include DNA, other molecules, and potentially many organisms, especially microbes, and 3 survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and

  7. Semantics in Support of Biodiversity Knowledge Discovery: An Introduction to the Biological Collections Ontology and Related Ontologies

    Science.gov (United States)

    Baskauf, Steve; Blum, Stanley; Bowers, Shawn; Davies, Neil; Endresen, Dag; Gandolfo, Maria Alejandra; Hanner, Robert; Janning, Alyssa; Krishtalka, Leonard; Matsunaga, Andréa; Midford, Peter; Tuama, Éamonn Ó.; Schildhauer, Mark; Smith, Barry; Stucky, Brian J.; Thomer, Andrea; Wieczorek, John; Whitacre, Jamie; Wooley, John

    2014-01-01

    The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open Biological and Biomedical Ontologies (OBO) Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques), as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1) individual organisms, including voucher specimens from ecological studies and museum specimens, 2) bulk or environmental samples (e.g., gut contents, soil, water) that include DNA, other molecules, and potentially many organisms, especially microbes, and 3) survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and researchers

  8. Principals' Supervision and Evaluation Cycles: Perspectives from Principals

    Science.gov (United States)

    Hvidston, David J.; McKim, Courtney Ann; Mette, Ian M.

    2016-01-01

    The goals for this quantitative study were to examine principals' perceptions regarding supervision and evaluation within their own evaluations. Three research questions guided the inquiry: (1) What are the perceptions of principals' regarding their own supervision?; (2) What are the perceptions of principals' regarding their own evaluation?; and…

  9. Data structure characterization of miltispectral data using principal component and principal factor analysis

    Science.gov (United States)

    Lee, Jae K.; Mausel, Paul W.; Lulla, Kamlesh P.

    1989-01-01

    Both principal component analysis (PCA) and principal factor analysis (PFA) were used to analyze an experimental multispectral data structure in terms of common and unique variance. Only the common variance of the multispectral data was associated with the principal factor, while higher-order principal components were associated with both common and unique variance. The unique variance was found to represent small spectral variations within each cover type as well as noise vectors, and was most abundant in the lower-order principal components. The lower-order principal components can be useful in research designed to discriminate minor physical variations within features, and to highlight localized change when using multitemporal-multispectral data. Conversely, PFA of the multispectral data provided an insight into a great potential for discriminating basic land-cover types by excluding the unique variance which was related to the noise and minor spectral variations.

  10. Design of the DISCovery project: tailored work-oriented interventions to improve employee health, well-being, and performance-related outcomes in hospital care

    Directory of Open Access Journals (Sweden)

    Niks Irene MW

    2013-02-01

    Full Text Available Abstract Background It is well-known that health care workers in today’s general hospitals have to deal with high levels of job demands, which could have negative effects on their health, well-being, and job performance. A way to reduce job-related stress reactions and to optimize positive work-related outcomes is to raise the level of specific job resources and opportunities to recover from work. However, the question remains how to translate the optimization of the balance between job demands, job resources, and recovery opportunities into effective workplace interventions. The aim of the DISCovery project is to develop and implement tailored work-oriented interventions to improve health, well-being, and performance of health care personnel. Methods/Design A quasi-experimental field study with a non-equivalent control group pretest-posttest design will be conducted in a top general hospital. Four existing organizational departments will provide both an intervention and a comparison group. Two types of research methods are used: (1 a longitudinal web-based survey study, and (2 a longitudinal daily diary study. After base-line measures of both methods, existing and yet to be developed interventions will be implemented within the experimental groups. Follow-up measurements will be taken one and two years after the base-line measures to analyze short-term and long-term effects of the interventions. Additionally, a process evaluation and a cost-effectiveness analysis will be carried out. Discussion The DISCovery project fulfills a strong need for theory-driven and scientifically well-performed research on job stress and performance interventions. It will provide insight into (1 how a balance between job demands, job resources, and recovery from work can be optimized, (2 the short-term and long-term effects of tailored work-oriented effects, and (3 indicators for successful or unsuccessful implementation of interventions.

  11. Design of the DISCovery project: tailored work-oriented interventions to improve employee health, well-being, and performance-related outcomes in hospital care.

    Science.gov (United States)

    Niks, Irene M W; de Jonge, Jan; Gevers, Josette M P; Houtman, Irene L D

    2013-02-19

    It is well-known that health care workers in today's general hospitals have to deal with high levels of job demands, which could have negative effects on their health, well-being, and job performance. A way to reduce job-related stress reactions and to optimize positive work-related outcomes is to raise the level of specific job resources and opportunities to recover from work. However, the question remains how to translate the optimization of the balance between job demands, job resources, and recovery opportunities into effective workplace interventions. The aim of the DISCovery project is to develop and implement tailored work-oriented interventions to improve health, well-being, and performance of health care personnel. A quasi-experimental field study with a non-equivalent control group pretest-posttest design will be conducted in a top general hospital. Four existing organizational departments will provide both an intervention and a comparison group. Two types of research methods are used: (1) a longitudinal web-based survey study, and (2) a longitudinal daily diary study. After base-line measures of both methods, existing and yet to be developed interventions will be implemented within the experimental groups. Follow-up measurements will be taken one and two years after the base-line measures to analyze short-term and long-term effects of the interventions. Additionally, a process evaluation and a cost-effectiveness analysis will be carried out. The DISCovery project fulfills a strong need for theory-driven and scientifically well-performed research on job stress and performance interventions. It will provide insight into (1) how a balance between job demands, job resources, and recovery from work can be optimized, (2) the short-term and long-term effects of tailored work-oriented effects, and (3) indicators for successful or unsuccessful implementation of interventions.

  12. Identifying Predictors of Anti-VEGF Treatment Response in Patients with Neovascular Age-Related Macular Degeneration through Discriminant and Principal Component Analysis

    NARCIS (Netherlands)

    Holz, F.G.; Tadayoni, R.; Beatty, S.; Berger, A.R.; Cereda, M.G.; Hykin, P.; Hoyng, C.B.; Wittrup-Jensen, K.; Altemark, A.; Nilsson, J.; Kim, K.; Sivaprasad, S.

    2017-01-01

    OBJECTIVE: AURA was an observational study that monitored visual acuity outcomes following ranibizumab use in neovascular age-related macular degeneration patients over 2 years. The aim of this analysis was to identify factors that were predictive of visual acuity outcomes in AURA. METHODS: The

  13. Discovery of genes related to insecticide resistance in Bactrocera dorsalis by functional genomic analysis of a de novo assembled transcriptome.

    Directory of Open Access Journals (Sweden)

    Ju-Chun Hsu

    Full Text Available Insecticide resistance has recently become a critical concern for control of many insect pest species. Genome sequencing and global quantization of gene expression through analysis of the transcriptome can provide useful information relevant to this challenging problem. The oriental fruit fly, Bactrocera dorsalis, is one of the world's most destructive agricultural pests, and recently it has been used as a target for studies of genetic mechanisms related to insecticide resistance. However, prior to this study, the molecular data available for this species was largely limited to genes identified through homology. To provide a broader pool of gene sequences of potential interest with regard to insecticide resistance, this study uses whole transcriptome analysis developed through de novo assembly of short reads generated by next-generation sequencing (NGS. The transcriptome of B. dorsalis was initially constructed using Illumina's Solexa sequencing technology. Qualified reads were assembled into contigs and potential splicing variants (isotigs. A total of 29,067 isotigs have putative homologues in the non-redundant (nr protein database from NCBI, and 11,073 of these correspond to distinct D. melanogaster proteins in the RefSeq database. Approximately 5,546 isotigs contain coding sequences that are at least 80% complete and appear to represent B. dorsalis genes. We observed a strong correlation between the completeness of the assembled sequences and the expression intensity of the transcripts. The assembled sequences were also used to identify large numbers of genes potentially belonging to families related to insecticide resistance. A total of 90 P450-, 42 GST-and 37 COE-related genes, representing three major enzyme families involved in insecticide metabolism and resistance, were identified. In addition, 36 isotigs were discovered to contain target site sequences related to four classes of resistance genes. Identified sequence motifs were also

  14. Principals' Relationship with Computer Technology

    Science.gov (United States)

    Brockmeier, Lantry L.; Sermon, Janet M.; Hope, Warren C.

    2005-01-01

    This investigation sought information about principals and their relationship with computer technology. Several questions were fundamental to the inquiry. Are principals prepared to facilitate the attainment of technology's promise through the integration of computer technology into the teaching and learning process? Are principals prepared to use…

  15. School Principals' Emotional Coping Process

    Science.gov (United States)

    Poirel, Emmanuel; Yvon, Frédéric

    2014-01-01

    The present study examines the emotional coping of school principals in Quebec. Emotional coping was measured by stimulated recall; six principals were filmed during a working day and presented a week later with their video showing stressful encounters. The results show that school principals experience anger because of reproaches from staff…

  16. Principals' Salaries, 2007-2008

    Science.gov (United States)

    Cooke, Willa D.; Licciardi, Chris

    2008-01-01

    How do salaries of elementary and middle school principals compare with those of other administrators and classroom teachers? Are increases in salaries of principals keeping pace with increases in salaries of classroom teachers? And how have principals' salaries fared over the years when the cost of living is taken into account? There are reliable…

  17. Transcriptome-based discovery of AP2/ERF transcription factors related to temperature stress in tea plant (Camellia sinensis).

    Science.gov (United States)

    Wu, Zhi-Jun; Li, Xing-Hui; Liu, Zhi-Wei; Li, Hui; Wang, Yong-Xin; Zhuang, Jing

    2015-11-01

    Tea plant (Camellia sinensis) is an important natural resource for the global supply of non-alcoholic beverage production. The extension of tea plant cultivation is challenged by biotic and abiotic stresses. Transcription factors (TFs) of the APETALA 2 (AP2)/ethylene-responsive factor (ERF) family are involved in growth and anti-stresses through multifaceted transcriptional regulation in plants. This study comprehensively analyzed AP2/ERF family TFs from C. sinensis on the basis of the transcriptome sequencing data of four tea plant cultivars, namely, 'Yunnanshilixiang', 'Chawansanhao', 'Ruchengmaoyecha', and 'Anjibaicha'. A total of 89 putative AP2/ERF transcription factors with full-length AP2 domain were identified from C. sinensis and classified into five subfamilies, namely, AP2, dehydration-responsive-element-binding (DREB), ERF, related to ABI3/VP (RAV), and Soloist. All identified CsAP2/ERF genes presented relatively stable expression levels in the four tea plant cultivars. Many groups also showed cultivar specificity. Five CsAP2/ERF genes from each AP2/ERF subfamily (DREB, ERF, AP2, and RAV) were related to temperature stresses; these results indicated that AP2/ERF TFs may play important roles in abnormal temperature stress response in C. sinensis.

  18. Discovery of Consistent QTLs of Wheat Spike-Related Traits under Nitrogen Treatment at Different Development Stages

    Directory of Open Access Journals (Sweden)

    Zhiying Deng

    2017-12-01

    Full Text Available Spike-related traits such as spike length (Sl, fertile spikelet number (Fsn, sterile spikelet number (Ssn, grain number per spike (Gns, and thousand-kernel weight (Tkw are important factors influencing wheat yield. However, reliably stable markers that can be used for molecular breeding in different environments have not yet been identified. In this study, a double haploid (DH population was used for quantitative trait locus (QTL mapping of five spike-related traits under four different nitrogen (N supply dates in two locations and years. Seventy additive QTLs with phenotypic variation ranging from 4.12 to 34.74% and 10 major epistatic QTLs were identified. Eight important chromosomal regions on five chromosomes (1B, 2B, 2D, 5D, and 6A were found. Sixteen stable QTLs were detected for which N application had little effect. Among those stable QTLs, QSl.sdau-2D-1, and QSl.sdau-2D-2, with phenotypic variation explained (PVE of 10.4 and 24.2%, respectively, were flanked by markers Xwmc112 and Xcfd53 in the same order. The QTLs QSsn.sdau-2B-1, QFsn.sdau-2B-1, and QGns.sdau-2B, with PVE ranging from 4.37 to 28.43%, collocated in the Xwmc179-Xbarc373 marker interval. The consistent kernel wheat QTL (QTkw.sdau-6A on the long arm of chromosome 6A, flanked by SSR markers Xbarc1055 and Xwmc553, showed PVE of 5.87–15.18%. Among these stable QTLs, the two flanking markers Xwmc112 and Xcfd53 have been validated using different varieties and populations for selecting Sl. Therefore, these results will be of great value for marker-assisted selection (MAS in breeding programs and will accelerate the understanding of the genetic relationships among spike-related traits at the molecular level.

  19. Discovery of Consistent QTLs of Wheat Spike-Related Traits under Nitrogen Treatment at Different Development Stages.

    Science.gov (United States)

    Deng, Zhiying; Cui, Yong; Han, Qingdian; Fang, Wenqi; Li, Jifa; Tian, Jichun

    2017-01-01

    Spike-related traits such as spike length (Sl), fertile spikelet number (Fsn), sterile spikelet number (Ssn), grain number per spike (Gns), and thousand-kernel weight (Tkw) are important factors influencing wheat yield. However, reliably stable markers that can be used for molecular breeding in different environments have not yet been identified. In this study, a double haploid (DH) population was used for quantitative trait locus (QTL) mapping of five spike-related traits under four different nitrogen (N) supply dates in two locations and years. Seventy additive QTLs with phenotypic variation ranging from 4.12 to 34.74% and 10 major epistatic QTLs were identified. Eight important chromosomal regions on five chromosomes (1B, 2B, 2D, 5D, and 6A) were found. Sixteen stable QTLs were detected for which N application had little effect. Among those stable QTLs, QSl.sdau-2D-1 , and QSl.sdau-2D-2 , with phenotypic variation explained (PVE) of 10.4 and 24.2%, respectively, were flanked by markers Xwmc112 and Xcfd53 in the same order. The QTLs QSsn.sdau-2B-1, QFsn.sdau-2B-1 , and QGns.sdau-2B , with PVE ranging from 4.37 to 28.43%, collocated in the Xwmc179 - Xbarc373 marker interval. The consistent kernel wheat QTL ( QTkw.sdau-6A ) on the long arm of chromosome 6A, flanked by SSR markers Xbarc1055 and Xwmc553 , showed PVE of 5.87-15.18%. Among these stable QTLs, the two flanking markers Xwmc112 and Xcfd53 have been validated using different varieties and populations for selecting Sl. Therefore, these results will be of great value for marker-assisted selection (MAS) in breeding programs and will accelerate the understanding of the genetic relationships among spike-related traits at the molecular level.

  20. Discovery of coding genetic variants influencing diabetes-related serum biomarkers and their impact on risk of type 2 diabetes

    DEFF Research Database (Denmark)

    Ahluwalia, Tarunveer Singh; Allin, Kristine Højgaard; Sandholt, Camilla Helene

    2015-01-01

    CONTEXT: Type 2 diabetes (T2D) prevalence is spiraling globally, and knowledge of its pathophysiological signatures is crucial for a better understanding and treatment of the disease. OBJECTIVE: We aimed to discover underlying coding genetic variants influencing fasting serum levels of nine......, of which the association with the CELSR2 locus has not been shown previously. CONCLUSION: The identified loci influence processes related to insulin signaling, cell communication, immune function, apoptosis, DNA repair, and oxidative stress, all of which could provide a rationale for novel diabetes...

  1. Lead Discovery for Alzheimer’s Disease Related Target Protein RbAp48 from Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Hung-Jin Huang

    2014-01-01

    Full Text Available Deficiency or loss of function of Retinoblastoma-associated proteins (RbAp48 is related with Alzheimer’s disease (AD, and AD disease is associated with age-related memory loss. During normal function, RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1 and has a role in gene transcription, but an unstable complex may affect the function of RbAp48. This study utilizes the world’s largest traditional Chinese medicine (TCM database and virtual screening to provide potential compounds for RbAp48 binding. A molecular dynamics (MD simulation was employed to understand the variations after protein-ligand interaction. FOG1 was found to exhibit low stability after RbAp48 binding; the peptide displayed significant movement from the initial docking position, a phenomenon which matched the docking results. The protein structure of the other TCM candidates was not variable during MD simulation and had a greater stable affinity for RbAp48 binding than FOG1. Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.

  2. Le principe roman

    CERN Document Server

    Ferrari, Jérôme

    2015-01-01

    Fasciné par la figure du physicien allemand Werner Heisenberg (1901-1976), fondateur de la mécanique quantique, inventeur du célèbre "principe d'incertitude" et Prix Nobel de physique en 1932, un jeune aspirant-philosophe désenchanté s'efforce, à l'aube du XXIe siècle, de considérer l'incomplétude de sa propre existence à l'aune des travaux et de la destinée de cet exceptionnel homme de sciences qui incarne pour lui la rencontre du langage scientifique et de la poésie, lesquels, chacun à leur manière, en ouvrant la voie au scandale de l'inédit, dessillent les yeux sur le monde pour en révéler la mystérieuse beauté que ne cessent de confisquer le matérialisme à l'œuvre dans l'Histoire des hommes.

  3. Principal oscillation patterns

    International Nuclear Information System (INIS)

    Storch, H. von; Buerger, G.; Storch, J.S. von

    1993-01-01

    The Principal Oscillation Pattern (POP) analysis is a technique which is used to simultaneously infer the characteristic patterns and time scales of a vector time series. The POPs may be seen as the normal modes of a linearized system whose system matrix is estimated from data. The concept of POP analysis is reviewed. Examples are used to illustrate the potential of the POP technique. The best defined POPs of tropospheric day-to-day variability coincide with the most unstable modes derived from linearized theory. POPs can be derived even from a space-time subset of data. POPs are successful in identifying two independent modes with similar time scales in the same data set. The POP method can also produce forecasts which may potentially be used as a reference for other forecast models. The conventional POP analysis technique has been generalized in various ways. In the cyclostationary POP analysis, the estimated system matrix is allowed to vary deterministically with an externally forced cycle. In the complex POP analysis not only the state of the system but also its ''momentum'' is modeled. Associated correlation patterns are a useful tool to describe the appearance of a signal previously identified by a POP analysis in other parameters. (orig.)

  4. Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

    Directory of Open Access Journals (Sweden)

    Momoko Horikoshi

    2015-07-01

    Full Text Available Reference panels from the 1000 Genomes (1000G Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS, supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI at genome-wide significance, and two for fasting glucose (FG, none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3 and FG (GCK and G6PC2. The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated.

  5. Principal stratification in causal inference.

    Science.gov (United States)

    Frangakis, Constantine E; Rubin, Donald B

    2002-03-01

    Many scientific problems require that treatment comparisons be adjusted for posttreatment variables, but the estimands underlying standard methods are not causal effects. To address this deficiency, we propose a general framework for comparing treatments adjusting for posttreatment variables that yields principal effects based on principal stratification. Principal stratification with respect to a posttreatment variable is a cross-classification of subjects defined by the joint potential values of that posttreatment variable tinder each of the treatments being compared. Principal effects are causal effects within a principal stratum. The key property of principal strata is that they are not affected by treatment assignment and therefore can be used just as any pretreatment covariate. such as age category. As a result, the central property of our principal effects is that they are always causal effects and do not suffer from the complications of standard posttreatment-adjusted estimands. We discuss briefly that such principal causal effects are the link between three recent applications with adjustment for posttreatment variables: (i) treatment noncompliance, (ii) missing outcomes (dropout) following treatment noncompliance. and (iii) censoring by death. We then attack the problem of surrogate or biomarker endpoints, where we show, using principal causal effects, that all current definitions of surrogacy, even when perfectly true, do not generally have the desired interpretation as causal effects of treatment on outcome. We go on to forrmulate estimands based on principal stratification and principal causal effects and show their superiority.

  6. Taking a Distributed Perspective to the School Principal's Workday

    Science.gov (United States)

    Spillane, James P.; Camburn, Eric M.; Pareja, Amber Stitziel

    2007-01-01

    Focusing on the school principal's day-to-day work, we examine who leads curriculum and instruction- and administration-related activities when the school principal is not leading but participating in the activity. We also explore the prevalence of coperformance of management and leadership activities in the school principal's workday. Looking…

  7. Discovery of coding genetic variants influencing diabetes-related serum biomarkers and their impact on risk of type 2 diabetes.

    Science.gov (United States)

    Ahluwalia, Tarunveer Singh; Allin, Kristine Højgaard; Sandholt, Camilla Helene; Sparsø, Thomas Hempel; Jørgensen, Marit Eika; Rowe, Michael; Christensen, Cramer; Brandslund, Ivan; Lauritzen, Torsten; Linneberg, Allan; Husemoen, Lise Lotte; Jørgensen, Torben; Hansen, Torben; Grarup, Niels; Pedersen, Oluf

    2015-04-01

    Type 2 diabetes (T2D) prevalence is spiraling globally, and knowledge of its pathophysiological signatures is crucial for a better understanding and treatment of the disease. We aimed to discover underlying coding genetic variants influencing fasting serum levels of nine biomarkers associated with T2D: adiponectin, C-reactive protein, ferritin, heat shock 70-kDa protein 1B, IGF binding protein 1 and IGF binding protein 2, IL-18, IL-2 receptor-α, and leptin. A population-based sample of 6215 adult Danes was genotyped for 16 340 coding single-nucleotide polymorphisms and were tested for association with each biomarker. Identified loci were tested for association with T2D through a large-scale meta-analysis involving up to 17 024 T2D cases and up to 64 186 controls. We discovered 11 associations between single-nucleotide polymorphisms and five distinct biomarkers at a study-wide P < 3.4 × 10(-7). Nine associations were novel: IL18: BIRC6, RAD17, MARVELD2; ferritin: F5; IGF binding protein 1: SERPING1, KLKB, GCKR, CELSR2, and heat shock 70-kDa protein 1B: CFH. Three of the identified loci (CELSR2, HNF1A, and GCKR) were significantly associated with T2D, of which the association with the CELSR2 locus has not been shown previously. The identified loci influence processes related to insulin signaling, cell communication, immune function, apoptosis, DNA repair, and oxidative stress, all of which could provide a rationale for novel diabetes therapeutic strategies.

  8. Principals' Perceptions Regarding Their Supervision and Evaluation

    Science.gov (United States)

    Hvidston, David J.; Range, Bret G.; McKim, Courtney Ann

    2015-01-01

    This study examined the perceptions of principals concerning principal evaluation and supervisory feedback. Principals were asked two open-ended questions. Respondents included 82 principals in the Rocky Mountain region. The emerging themes were "Superintendent Performance," "Principal Evaluation Components," "Specific…

  9. Educational Leadership in the Age of Diversity: A Case Study of Middle School Principals' Cultural Awareness and Influence in Relation to Teachers' Cultural Awareness and the Use of Culturally Responsive Curriculum and Pedagogy in Classrooms

    Science.gov (United States)

    Robinson, Lynda Marie Cesare

    2010-01-01

    This embedded case study examined middle school principals' self-reported cultural awareness, teachers' self-reported cultural awareness, and principals' influence on cultural awareness in the school. In addition, the study focused on how principals influenced teachers' cultural awareness and implementation of multicultural education, and…

  10. Literature-Related Discovery (LRD)

    Science.gov (United States)

    2007-11-01

    tended to select larger numbers of phrases, with the bulk being moderately specific and some being more generic. In a sense, we hedged our bets, to...resistance to aggregation (Felton, 1980) Soybean Phosphatidylcholine MED/ MED MED/ MED The [cholesterol] lowering was accompanied by a reduction...positively charged micelles of soybean phosphatidylcholine. That lowering was accompanied by a reduction in membrane microviscosity, rise of the activity

  11. The Effective and Reflective Principal

    Science.gov (United States)

    Ritchie, John M.

    2013-01-01

    For a "Kappan" issue focusing on the job of the principal, this is an essay from a retired, longtime principal and superintendent. "I have notebooks full of advice that I've collected over the years: tips, mantras, cautions, and quotations appropriate for any occasion," the author says. "I learned to focus less on…

  12. Discovery of discriminatory quality control markers for Chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods: Radix Scutellariae as a case study.

    Science.gov (United States)

    Wang, Fei; Wang, Bo; Wang, Long; Xiong, Zi-Yue; Gao, Wen; Li, Ping; Li, Hui-Jun

    2017-05-10

    The processing procedure of traditional Chinese herbal medicines (CHMs) plays an essential role in clinical applications. However, little progress has been made on the quality control of crude and processed products. The present work, taking Radix Scutellariae (RS), wine-processed RS and carbonized RS as a typical case, developed a comprehensive strategy integrating chromatographic analysis and chemometric methods for quality evaluation and discrimination of crude RS and its processed products. Chemical fingerprints were established by high-performance liquid chromatography coupled with photodiode array detector and quadrupole time-of-flight mass spectrometry, and similarity analyses were calculated based on eleven common characteristic peaks. Subsequently, four chemical markers were discovered by back propagation-artificial neural network (BP-ANN) modeling. The selected markers were quantified by the 'single standard to determine multi-components' (SSDMC) method, and then the quantitative data were subjected to principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA). Furthermore, support vector machine (SVM) was employed to predict the different processed products of RS. Finally, a hotmap visualization was conducted for clarifying the distribution of major flavonoids among different drugs. Collectively, the proposed strategy might be well-acceptable for quality control of CHMs and their related processed products from the processing mechanism-based perspective. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Assessment of School Principals' Reassignment Process

    Science.gov (United States)

    Sezgin-Nartgün, Senay; Ekinci, Serkan

    2016-01-01

    This study aimed to identify administrators' views related to the assessment of school principals' reassignment in educational organizations. The study utilized qualitative research design and the study group composed of 8 school administrators selected via simple sampling who were employed in the Bolu central district in 2014-2015 academic year.…

  14. Geometry of Quantum Principal Bundles. Pt. 1

    International Nuclear Information System (INIS)

    Durdevic, M.

    1996-01-01

    A theory of principal bundles possessing quantum structure groups and classical base manifolds is presented. Structural analysis of such quantum principal bundles is performed. A differential calculus is constructed, combining differential forms on the base manifold with an appropriate differential calculus on the structure quantum group. Relations between the calculus on the group and the calculus on the bundle are investigated. A concept of (pseudo)tensoriality is formulated. The formalism of connections is developed. In particular, operators of horizontal projection, covariant derivative and curvature are constructed and analyzed. Generalizations of the first Structure Equation and of the Bianchi identity are found. Illustrative examples are presented. (orig.)

  15. Relations of Principal Components Analysis Site Scores to Algal-Biomass, Habitat, Basin-Characteristics, Nutrient, and Biological-Community Data in the Whitewater River and East Fork White River Basins, Indiana, 2002

    Science.gov (United States)

    Caskey, Brian J.; Frey, Jeffrey W.; Lowe, B. Scott

    2007-01-01

    Data were gathered from May through September 2002 at 76 randomly selected sites in the Whitewater River and East Fork White River Basins, Indiana, for algal biomass, habitat, nutrients, and biological communities (fish and invertebrates). Basin characteristics (land use and drainage area) and biolog-ical-community attributes and metric scores were determined for the basin of each sampling site. Yearly Principal Compo-nents Analysis site scores were calculated for algal biomass (periphyton and seston). The yearly Principal Components Analysis site scores for the first axis (PC1) were related using Spearman's rho to the seasonal algal-biomass, basin-charac-teristics, habitat, seasonal nutrient, and biological-community attribute and metric score data. The periphyton PC1 site score was not significantly related to the nine habitat or 12 nutrient variables examined. One land-use variable, drainage area, was negatively related to the periphyton PC1. Of the 43 fish-community attributes and metrics examined, the periphyton PC1 was negatively related to one attribute (large-river percent) and one metric score (car-nivore percent metric score). It was positively related to three fish-community attributes (headwater percent, pioneer percent, and simple lithophil percent). The periphyton PC1 was not statistically related to any of the 21 invertebrate-community attributes or metric scores examined. Of the 12 nutrient variables examined two were nega-tively related to the seston PC1 site score in two seasons: total Kjeldahl nitrogen (July and September), and TP (May and September). There were no statistically significant relations between the seston PC1 and the five basin-characteristics or nine habitat variables examined. Of the 43 fish-community attributes and metrics examined, the seston PC1 was positively related to one attribute (headwater percent) and negatively related to one metric score (large-river percent metric score) . Of the 21 invertebrate-community attributes

  16. Principal modes in multimode waveguides.

    Science.gov (United States)

    Fan, Shanhui; Kahn, Joseph M

    2005-01-15

    We generalize the concept of principal states of polarization and prove the existence of principal modes in multimode waveguides. Principal modes do not suffer from modal dispersion to first order of frequency variation and form orthogonal bases at both the input and the output ends of the waveguide. We show that principal modes are generally different from eigenmodes, even in uniform waveguides, unlike the special case of a single-mode fiber with uniform birefringence. The difference is most pronounced when different eigenmodes possess similar group velocities and when their field patterns vary as a function of frequency. This work may provide a new basis for analysis and control of dispersion in multimode fiber systems.

  17. Topology Discovery Using Cisco Discovery Protocol

    OpenAIRE

    Rodriguez, Sergio R.

    2009-01-01

    In this paper we address the problem of discovering network topology in proprietary networks. Namely, we investigate topology discovery in Cisco-based networks. Cisco devices run Cisco Discovery Protocol (CDP) which holds information about these devices. We first compare properties of topologies that can be obtained from networks deploying CDP versus Spanning Tree Protocol (STP) and Management Information Base (MIB) Forwarding Database (FDB). Then we describe a method of discovering topology ...

  18. 15 CFR 785.8 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 785.8 Section 785.8 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS ENFORCEMENT § 785.8 Discovery...

  19. Surface analysis the principal techniques

    CERN Document Server

    Vickerman, John C

    2009-01-01

    This completely updated and revised second edition of Surface Analysis: The Principal Techniques, deals with the characterisation and understanding of the outer layers of substrates, how they react, look and function which are all of interest to surface scientists. Within this comprehensive text, experts in each analysis area introduce the theory and practice of the principal techniques that have shown themselves to be effective in both basic research and in applied surface analysis. Examples of analysis are provided to facilitate the understanding of this topic and to show readers how they c

  20. El Cenozoico del alto río Teno, Cordillera Principal, Chile central: estratigrafía, plutonismo y su relación con estructuras profundas The Cenozoic of the upper Teno River, Cordillera Principal, Central Chile: stratigraphy, plutonism and their relation with deep structures

    Directory of Open Access Journals (Sweden)

    José Piquer

    2010-01-01

    ío, focalizando el ascenso de los intrusivos mencionados.The Cenozoic geologic evolution of the central part of the Cordillera Principal at ~35°S, is intimately related to the geodynamic evolution of deep crustal structures, which during different stages contra lled the deposition of volcanosedimentary sequences, and the ascent and emplacement of epizonal intrusions. Newly defined stratigraphy around these structures confirms the Cenozoic age of a group of pyroclastic and sedimentary rocks, which conformably underlie andesitic lavas of the Abanico Formation (assigned to the Late Eocene-Early to Middle Miocene. Intrusive rocks correspond to four main phases (from oldest to youngest: diorite, granodiorite, rhyo-dacitic and dacitic porphyry, which oceurs in a North-South trending belt. The granodiorite was dated at 7.8+0.4 Ma (K-Ar in biotite. Rhyo-dacitic porphyries, considered as a marginal lithodeme of the granodiorite, yielded 7.9+0.4 Ma (K-Ar in plagioclase phenocrysts. Two main structures of regional importance were observed: the El Fierro thrust, and, towards the west, the Infiernillo-Los Cipreses Fault System. In the characterization of the latter, magnetic modeling of cross-sections were analyzed as a complement to the geologic information. The ascent of the different intrusive phases mentioned before, is interpreted as being controlled by the Infiernillo-Los Cipreses Fault System. This structure, as well as the El Fierro thrust, acted as a basin-margin normal fault during the Late Eocene-Mddle Mocene, contralling the deposition of the Abanico Formation. These faults were reactivated as reverse faults during an episode of major tectonic contraction and magmatic-induced high fluid pressure in the Late Mocene, focusing the ascent of the intrusive bodies.

  1. Hippocampus discovery First steps

    Directory of Open Access Journals (Sweden)

    Eliasz Engelhardt

    Full Text Available The first steps of the discovery, and the main discoverers, of the hippocampus are outlined. Arantius was the first to describe a structure he named "hippocampus" or "white silkworm". Despite numerous controversies and alternate designations, the term hippocampus has prevailed until this day as the most widely used term. Duvernoy provided an illustration of the hippocampus and surrounding structures, considered the first by most authors, which appeared more than one and a half century after Arantius' description. Some authors have identified other drawings and texts which they claim predate Duvernoy's depiction, in studies by Vesalius, Varolio, Willis, and Eustachio, albeit unconvincingly. Considering the definition of the hippocampal formation as comprising the hippocampus proper, dentate gyrus and subiculum, Arantius and Duvernoy apparently described the gross anatomy of this complex. The pioneering studies of Arantius and Duvernoy revealed a relatively small hidden formation that would become one of the most valued brain structures.

  2. 24 CFR 206.211 - Annual determination of principal residence.

    Science.gov (United States)

    2010-04-01

    ... residence. 206.211 Section 206.211 Housing and Urban Development Regulations Relating to Housing and Urban... determination of principal residence. At least once during each calendar year, the mortgagee shall determine whether or not the property is the principal residence of at least one mortgagor. The mortgagee shall...

  3. The Principal and Tort Liability.

    Science.gov (United States)

    Stern, Ralph D.

    The emphasis of this chapter is on the tort liability of principals, especially their commission of unintentional torts or torts resulting from negligent conduct. A tort is defined as a wrongful act, not including a breach of contract or trust, which results in injury to another's person, property, or reputation and for which the injured party is…

  4. Computer Use by Rural Principals.

    Science.gov (United States)

    Witten, D. W.; And Others

    Very little research is available nationwide that measures the administrative use of computers in rural schools. A state survey of 154 rural Kentucky secondary school principals (representing a 51% response rate) focused on their knowledge about computers and use of computers for school administrative purposes. Only 14% of respondents had a…

  5. School Uniforms: Guidelines for Principals.

    Science.gov (United States)

    Essex, Nathan L.

    2001-01-01

    Principals desiring to develop a school-uniform policy should involve parents, teachers, community leaders, and student representatives; beware restrictions on religious and political expression; provide flexibility and assistance for low-income families; implement a pilot program; align the policy with school-safety issues; and consider legal…

  6. Principal Leadership in Taiwan Schools

    Science.gov (United States)

    Shouse, Roger C.; Lin, Kuan-Pei

    2010-01-01

    During the past two decades, Taiwan's Ministry of Education has responded to globalization by restructuring school curricular, instructional, and decision making practices along western lines in an attempt to attain legitimacy on the world stage. As a result, Taiwanese principals, once kings within their schools, now must share power with other…

  7. The Impact of Pay Satisfaction and School Achievement on High School Principals' Turnover Intentions

    Science.gov (United States)

    Tran, Henry

    2017-01-01

    In recent years, a principal supply shortage crisis has emerged in the USA. This problem has been exacerbated by an increase in principal departures, which has been found to be negatively related to school outcomes. While research exists on several determinants of principal turnover, any examination of the relationship between principals'…

  8. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic and organi......Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...... their performance....

  9. COPD phenotype description using principal components analysis

    DEFF Research Database (Denmark)

    Roy, Kay; Smith, Jacky; Kolsum, Umme

    2009-01-01

    BACKGROUND: Airway inflammation in COPD can be measured using biomarkers such as induced sputum and Fe(NO). This study set out to explore the heterogeneity of COPD using biomarkers of airway and systemic inflammation and pulmonary function by principal components analysis (PCA). SUBJECTS...... AND METHODS: In 127 COPD patients (mean FEV1 61%), pulmonary function, Fe(NO), plasma CRP and TNF-alpha, sputum differential cell counts and sputum IL8 (pg/ml) were measured. Principal components analysis as well as multivariate analysis was performed. RESULTS: PCA identified four main components (% variance...... associations between the variables within components 1 and 2. CONCLUSION: COPD is a multi dimensional disease. Unrelated components of disease were identified, including neutrophilic airway inflammation which was associated with systemic inflammation, and sputum eosinophils which were related to increased Fe...

  10. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several

  11. Service Discovery At Home

    NARCIS (Netherlands)

    Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.

    Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent

  12. OPEN DATA FOR DISCOVERY SCIENCE.

    Science.gov (United States)

    Payne, Philip R O; Huang, Kun; Shah, Nigam H; Tenenbaum, Jessica

    2017-01-01

    The modern healthcare and life sciences ecosystem is moving towards an increasingly open and data-centric approach to discovery science. This evolving paradigm is predicated on a complex set of information needs related to our collective ability to share, discover, reuse, integrate, and analyze open biological, clinical, and population level data resources of varying composition, granularity, and syntactic or semantic consistency. Such an evolution is further impacted by a concomitant growth in the size of data sets that can and should be employed for both hypothesis discovery and testing. When such open data can be accessed and employed for discovery purposes, a broad spectrum of high impact end-points is made possible. These span the spectrum from identification of de novo biomarker complexes that can inform precision medicine, to the repositioning or repurposing of extant agents for new and cost-effective therapies, to the assessment of population level influences on disease and wellness. Of note, these types of uses of open data can be either primary, wherein open data is the substantive basis for inquiry, or secondary, wherein open data is used to augment or enrich project-specific or proprietary data that is not open in and of itself. This workshop is concerned with the key challenges, opportunities, and methodological best practices whereby open data can be used to drive the advancement of discovery science in all of the aforementioned capacities.

  13. "Eureka, Eureka!" Discoveries in Science

    Science.gov (United States)

    Agarwal, Pankaj

    2011-01-01

    Accidental discoveries have been of significant value in the progress of science. Although accidental discoveries are more common in pharmacology and chemistry, other branches of science have also benefited from such discoveries. While most discoveries are the result of persistent research, famous accidental discoveries provide a fascinating…

  14. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    :200). The South African education .... related ideal would determine the principals' morale, motivation and job satisfaction. This conception of an .... scribing these verbatim, and presenting direct quotes from interviews in the results. The results.

  15. A quantum causal discovery algorithm

    Science.gov (United States)

    Giarmatzi, Christina; Costa, Fabio

    2018-03-01

    Finding a causal model for a set of classical variables is now a well-established task—but what about the quantum equivalent? Even the notion of a quantum causal model is controversial. Here, we present a causal discovery algorithm for quantum systems. The input to the algorithm is a process matrix describing correlations between quantum events. Its output consists of different levels of information about the underlying causal model. Our algorithm determines whether the process is causally ordered by grouping the events into causally ordered non-signaling sets. It detects if all relevant common causes are included in the process, which we label Markovian, or alternatively if some causal relations are mediated through some external memory. For a Markovian process, it outputs a causal model, namely the causal relations and the corresponding mechanisms, represented as quantum states and channels. Our algorithm opens the route to more general quantum causal discovery methods.

  16. Meeting report on the Alzheimer?s Drug Discovery Foundation 14th International Conference on Alzheimer?s Drug Discovery

    OpenAIRE

    Friedman, Lauren G; Price, Katherine; Lane, Rachel F; Carman, Aaron J; Dacks, Penny A; Shineman, Diana W; Fillit, Howard M

    2014-01-01

    The Alzheimer?s Drug Discovery Foundation?s 14th International Conference on Alzheimer?s Drug Discovery was held on 9 and 10 September in Jersey City, NJ, USA. This annual meeting highlights novel therapeutic approaches supported by the Alzheimer?s Drug Discovery Foundation in development for Alzheimer?s disease and related dementias.

  17. 1 April 2014 - President of the Parliament of the Principality of Liechtenstein A. Frick and his delegation visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez and signing the Guest book with CERN Director-General R. Heuer. Deputy Head of International Relations E. Tsesmelis present throughout.

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    1 April 2014 - President of the Parliament of the Principality of Liechtenstein A. Frick and his delegation visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez and signing the Guest book with CERN Director-General R. Heuer. Deputy Head of International Relations E. Tsesmelis present throughout.

  18. Female Principals in Education: Breaking the Glass Ceiling in Spain

    Directory of Open Access Journals (Sweden)

    Enrique Javier Diez Gutierrez

    Full Text Available Abstract Spanish schools are characterised by having a high proportion of female staff. However, statistics show that a proportionately higher number of men hold leadership positions. The aim of this study was to analyse the reasons why this is so, and to determine the motivations and barriers that women encounter in attaining and exercising these positions of greater responsibility and power. Questionnaires were administered to 2,022 female teachers, 430 female principals and 322 male principals. In addition, semi-structured interviews were held with 60 female principals, 14 focus group discussions were held with female principals and 16 autobiographical narratives were compiled with female principals and school inspectors. The reasons identified were related to structural aspects linked to the patriarchal worldview that is still dominant in our society and culture. Nevertheless, we also found motivations among women for attaining and exercising leadership roles.

  19. Principal chiral model on superspheres

    Energy Technology Data Exchange (ETDEWEB)

    Mitev, V.; Schomerus, V. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Quella, T. [Amsterdam Univ. (Netherlands). Inst. for Theoretical Physics

    2008-09-15

    We investigate the spectrum of the principal chiral model (PCM) on odd-dimensional superspheres as a function of the curvature radius R. For volume-filling branes on S{sup 3} {sup vertical} {sup stroke} {sup 2}, we compute the exact boundary spectrum as a function of R. The extension to higher dimensional superspheres is discussed, but not carried out in detail. Our results provide very convincing evidence in favor of the strong-weak coupling duality between supersphere PCMs and OSP(2S+2 vertical stroke 2S) Gross-Neveu models that was recently conjectured by Candu and Saleur. (orig.)

  20. Principal chiral model on superspheres

    International Nuclear Information System (INIS)

    Mitev, V.; Schomerus, V.; Quella, T.

    2008-09-01

    We investigate the spectrum of the principal chiral model (PCM) on odd-dimensional superspheres as a function of the curvature radius R. For volume-filling branes on S 3 vertical stroke 2 , we compute the exact boundary spectrum as a function of R. The extension to higher dimensional superspheres is discussed, but not carried out in detail. Our results provide very convincing evidence in favor of the strong-weak coupling duality between supersphere PCMs and OSP(2S+2 vertical stroke 2S) Gross-Neveu models that was recently conjectured by Candu and Saleur. (orig.)

  1. Principal Curves on Riemannian Manifolds

    DEFF Research Database (Denmark)

    Hauberg, Søren

    2015-01-01

    Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only...... in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimize a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend...

  2. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  3. School Principals' Perceptions of Ethically Just Responses to a Student Sexting Vignette: Severity of Administrator Response, Principal Personality, and Offender Gender and Race

    Science.gov (United States)

    Moriarty, Margaret E.

    2012-01-01

    This mixed-methods study was designed to determine how principals perceived the ethicality of sanctions for students engaged in sexting behavior relative to the race/ethnicity and gender of the student. Personality traits of the principals were surveyed to determine if Openness and/or Conscientiousness would predict principal response. Sexting is…

  4. Future of fundamental discovery in US biomedical research.

    Science.gov (United States)

    Levitt, Michael; Levitt, Jonathan M

    2017-06-20

    Young researchers are crucially important for basic science as they make unexpected, fundamental discoveries. Since 1982, we find a steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] younger than 46. This fall occurred over a 32-y period when inflation-corrected congressional funds for NIH almost tripled. During this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for younger PIs (below 46) and increased for older PIs (above 55). This age-related bias seems to have caused the steady drop in the number of young basic-science PIs and could reduce future US discoveries in fundamental biomedical science. The NIH recognized this bias in its 2008 early-stage investigator (ESI) policy to fund young PIs at higher rates. We show this policy is working and recommend that it be enhanced by using better data. Together with the National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA) program to reward senior PIs with research time in exchange for less funding, this may reverse a decades-long trend of more money going to older PIs. To prepare young scientists for increased demand, additional resources should be devoted to transitional postdoctoral fellowships already offered by NIH.

  5. Parametric functional principal component analysis.

    Science.gov (United States)

    Sang, Peijun; Wang, Liangliang; Cao, Jiguo

    2017-09-01

    Functional principal component analysis (FPCA) is a popular approach in functional data analysis to explore major sources of variation in a sample of random curves. These major sources of variation are represented by functional principal components (FPCs). Most existing FPCA approaches use a set of flexible basis functions such as B-spline basis to represent the FPCs, and control the smoothness of the FPCs by adding roughness penalties. However, the flexible representations pose difficulties for users to understand and interpret the FPCs. In this article, we consider a variety of applications of FPCA and find that, in many situations, the shapes of top FPCs are simple enough to be approximated using simple parametric functions. We propose a parametric approach to estimate the top FPCs to enhance their interpretability for users. Our parametric approach can also circumvent the smoothing parameter selecting process in conventional nonparametric FPCA methods. In addition, our simulation study shows that the proposed parametric FPCA is more robust when outlier curves exist. The parametric FPCA method is demonstrated by analyzing several datasets from a variety of applications. © 2017, The International Biometric Society.

  6. Walter Bonime's legacy: principal contributions.

    Science.gov (United States)

    Eckardt, Marianne Horney

    2002-01-01

    Walter Bonime is best known for his influential book, The Clinical Use of Dreams, published in 1962. Though Bonime embraced a neo-Freudian orientation, The Clinical Use of Dreams is remarkable for an absence of theoretical discussions, emphasizing instead a detailed practical approach, aided by illustrative vignettes. His particular emphases are on collaboration in the discovery of meaning and the importance of recognizing feeling representations in dreams. Further writings focussed on character disorders with depressive and paranoid symptomatology, vividly describing the typical underlying neurotic character structures. An outstanding article, co-authored with his wife Florence Bonime, criticizes the usual obscurity of psychoanalytic writings and suggests that conceptual abstractions be well balanced by clinical illustrations. Bonime's style is an exemplary model for such balanced writings.

  7. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  8. School Principals as Marketing Managers: The Expanding Role of Marketing for School Development

    Science.gov (United States)

    Anast-May, Linda; Mitchell, Mark; Buckner, Barbara Chesler; Elsberry, Cindy

    2012-01-01

    This study examined the relative importance that school principals attach to aspects of their role as marketing managers for their schools and their relative satisfaction with their efforts to date. The study included 60 principals from two school districts. Findings suggest that principals are aware of the importance of marketing in today's…

  9. The Role of Perceived Autonomy Support in Principals' Affective Organizational Commitment and Job Satisfaction

    Science.gov (United States)

    Chang, Yujin; Leach, Nicole; Anderman, Eric M.

    2015-01-01

    The purpose of this study is to examine the relations between principals' perceived autonomy support from superintendents, affective commitment to their school districts, and job satisfaction. We also explore possible moderation effects of principals' career experiences on these relations. Data were collected from K-12 public school principals in…

  10. On the antiproton discovery

    International Nuclear Information System (INIS)

    Piccioni, O.

    1989-01-01

    The author of this article describes his own role in the discovery of the antiproton. Although Segre and Chamberlain received the Nobel Prize in 1959 for its discovery, the author claims that their experimental method was his idea which he communicated to them informally in December 1954. He describes how his application for citizenship (he was Italian), and other scientists' manipulation, prevented him from being at Berkeley to work on the experiment himself. (UK)

  11. A Brief Account of the Discovery of the Fetal/Placental Unit for Estrogen Production in Equine and Human Pregnancies: Relation to Human Medicine.

    Science.gov (United States)

    Raeside, James I

    2017-09-01

    The role of steroids in human medicine is well recognized, but the major contributions made by the large domestic animals as a source of material in the discovery, isolation, and determination of the structure of the steroid hormones is less well appreciated. After a brief reminder of the early efforts to obtain a reliable source of steroids for clinical use, the narrative here is to outline one example where success was ultimately achieved for estrogen replacement therapy. Whereas knowledge of the high concentrations of estrogens in urine of pregnant women and mares dates from the late 1920s, it was not until the 1940s that the latter was shown to be a practical source. Initially, the placenta was held to be responsible, but the involvement of the fetus in each case was eventually established. The remarkable enlargement of the human fetal adrenal glands and the fetal gonads in the horse, with characteristic features of steroid secreting tissues, suggested their participation. Ultimately, it was 16-hydroxylation by the fetal liver that resulted in estriol being the major estrogen type, by far, in late human pregnancy. In the mare, the pattern of estrogen production reflected that of the growth and later regression of the fetal gonads. The characteristic production ring-B, unsaturated estrogens in the mare is derived from an alternative pathway involving retention of the additional double bond in the biosynthesis of equilin.

  12. Cyber-Enabled Scientific Discovery

    International Nuclear Information System (INIS)

    Chan, Tony; Jameson, Leland

    2007-01-01

    It is often said that numerical simulation is third in the group of three ways to explore modern science: theory, experiment and simulation. Carefully executed modern numerical simulations can, however, be considered at least as relevant as experiment and theory. In comparison to physical experimentation, with numerical simulation one has the numerically simulated values of every field variable at every grid point in space and time. In comparison to theory, with numerical simulation one can explore sets of very complex non-linear equations such as the Einstein equations that are very difficult to investigate theoretically. Cyber-enabled scientific discovery is not just about numerical simulation but about every possible issue related to scientific discovery by utilizing cyberinfrastructure such as the analysis and storage of large data sets, the creation of tools that can be used by broad classes of researchers and, above all, the education and training of a cyber-literate workforce

  13. On Bayesian Principal Component Analysis

    Czech Academy of Sciences Publication Activity Database

    Šmídl, Václav; Quinn, A.

    2007-01-01

    Roč. 51, č. 9 (2007), s. 4101-4123 ISSN 0167-9473 R&D Projects: GA MŠk(CZ) 1M0572 Institutional research plan: CEZ:AV0Z10750506 Keywords : Principal component analysis ( PCA ) * Variational bayes (VB) * von-Mises–Fisher distribution Subject RIV: BC - Control Systems Theory Impact factor: 1.029, year: 2007 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V8V-4MYD60N-6&_user=10&_coverDate=05%2F15%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b8ea629d48df926fe18f9e5724c9003a

  14. Principal Metabolic Flux Mode Analysis.

    Science.gov (United States)

    Bhadra, Sahely; Blomberg, Peter; Castillo, Sandra; Rousu, Juho; Wren, Jonathan

    2018-02-06

    In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior assumptions about the data, but does not inherently take into account the flux mode structure of metabolism. Stoichiometric flux analysis methods, such as Flux Balance Analysis (FBA) and Elementary Mode Analysis, on the other hand, are able to capture the metabolic flux modes, however, they are primarily designed for the analysis of single samples at a time, and not best suited for exploratory analysis on a large sets of samples. We propose a new methodology for the analysis of metabolism, called Principal Metabolic Flux Mode Analysis (PMFA), which marries the PCA and stoichiometric flux analysis approaches in an elegant regularized optimization framework. In short, the method incorporates a variance maximization objective form PCA coupled with a stoichiometric regularizer, which penalizes projections that are far from any flux modes of the network. For interpretability, we also introduce a sparse variant of PMFA that favours flux modes that contain a small number of reactions. Our experiments demonstrate the versatility and capabilities of our methodology. The proposed method can be applied to genome-scale metabolic network in efficient way as PMFA does not enumerate elementary modes. In addition, the method is more robust on out-of-steady steady-state experimental data than competing flux mode analysis approaches. Matlab software for PMFA and SPMFA and data set used for experiments are available in https://github.com/aalto-ics-kepaco/PMFA. sahely@iitpkd.ac.in, juho.rousu@aalto.fi, Peter.Blomberg@vtt.fi, Sandra.Castillo@vtt.fi. Detailed results are in Supplementary files. Supplementary data are available at https://github.com/aalto-ics-kepaco/PMFA/blob/master/Results.zip.

  15. Medicinal plants with antioxidant properties from Banat region (Romania: a rich pool for the discovery of multi-target phytochemicals active in free-radical related disorders

    Directory of Open Access Journals (Sweden)

    Diana Simona ANTAL

    2010-05-01

    Full Text Available Natural compounds from plants and other life forms (bacteria, fungi, marine organisms represent a major source of molecules with medicinal properties. Among them, antioxidant substances are of particular interest. The understanding of the central role that oxidative stress holds in the progression of disorders as varied as: cardiovascular diseases, degenerative conditions, rheumatic disorders, metabolic syndrome, and in aging, makes antioxidant capacity to a key-feature of modern, multipotent remedies. Rational screenings of the Plant Kingdom for the discovery of new medications are based on: a the inventory of available species, b knowledge accumulated from traditional phytotherapy, c already available results of recent investigations on bioactivity, d chemotaxonomic considerations, and e toxicologic facts. The objective of the present work is to set the starting point for a database of plants with antioxidant properties. It is projected to serve as a basic step for further investigations aimed at discovering biomolecules with multiple effects in free-radical mediated diseases and in gerontology. The research focuses on vascular plants with a history of utilization in phytotherapy, and growing wild in the Western part of Romania (Banat region. Based on the above inclusion criteria a – e, it was possible to point out over 140 plant species for which antioxidant activities were documented by different research groups. This impressive body of evidence provides valuable preliminary data for subsequent, more detailed research on the pharmacology, phytochemistry and clinical application of plants growing in Romania. The systematization of data performed in the present work is intended to help discover new, more efficient means to maintain and promote human health.

  16. Who Teaches, Who Principals, Who Learns?

    Science.gov (United States)

    O'Reilly, Gabrielle; Latimer, Milree

    An alternative framework that supports the collaboration of principals and teachers, with a focus on the changing roles of teachers and principals as learners and leaders, is presented. A conclusion is that as teachers' belief systems change to respect the image of the learner, principals' belief systems also change to reflect a new image of the…

  17. A principal-agent Model of corruption

    NARCIS (Netherlands)

    Groenendijk, Nico

    1997-01-01

    One of the new avenues in the study of political corruption is that of neo-institutional economics, of which the principal-agent theory is a part. In this article a principal-agent model of corruption is presented, in which there are two principals (one of which is corrupting), and one agent (who is

  18. Principals as Assessment Leaders in Rural Schools

    Science.gov (United States)

    Renihan, Patrick; Noonan, Brian

    2012-01-01

    This article reports a study of rural school principals' assessment leadership roles and the impact of rural context on their work. The study involved three focus groups of principals serving small rural schools of varied size and grade configuration in three systems. Principals viewed assessment as a matter of teacher accountability and as a…

  19. Principal Stability and the Rural Divide

    Science.gov (United States)

    Pendola, Andrew; Fuller, Edward J.

    2018-01-01

    This article examines the unique features of the rural school context and how these features are associated with the stability of principals in these schools. Given the small but growing literature on the characteristics of rural principals, this study presents an exploratory analysis of principal stability across schools located in different…

  20. Leadership Coaching for Principals: A National Study

    Science.gov (United States)

    Wise, Donald; Cavazos, Blanca

    2017-01-01

    Surveys were sent to a large representative sample of public school principals in the United States asking if they had received leadership coaching. Comparison of responses to actual numbers of principals indicates that the sample represents the first national study of principal leadership coaching. Results indicate that approximately 50% of all…

  1. Gender and Perceptions: Females as Secondary Principals

    Science.gov (United States)

    Nogay, Kathleen; Beebe, Robert J.

    2008-01-01

    The purpose of this study was to investigate the perceptions of teachers and supervisors toward the principal leadership behaviors of female secondary principals in Ohio. Principal self-perceptions were also included to complete the study. The literature shows that women continue to be underrepresented in a field in which the majority of…

  2. 24 CFR 206.39 - Principal residence.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Principal residence. 206.39 Section... CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgagors § 206.39 Principal residence. The property must be the principal residence of each mortgagor at closing. For purposes of this section, the...

  3. New Principal Coaching as a Safety Net

    Science.gov (United States)

    Celoria, Davide; Roberson, Ingrid

    2015-01-01

    This study examines new principal coaching as an induction process and explores the emotional dimensions of educational leadership. Twelve principal coaches and new principals--six of each--participated in this qualitative study that employed emergent coding (Creswell, 2008; Denzin, 2005; Glaser & Strauss, 1998; Spradley, 1979). The major…

  4. Principals' Collaborative Roles as Leaders for Learning

    Science.gov (United States)

    Kitchen, Margaret; Gray, Susan; Jeurissen, Maree

    2016-01-01

    This article draws on data from three multicultural New Zealand primary schools to reconceptualize principals' roles as leaders for learning. In doing so, the writers build on Sinnema and Robinson's (2012) article on goal setting in principal evaluation. Sinnema and Robinson found that even principals hand-picked for their experience fell short on…

  5. Teacher Supervision Practices and Principals' Characteristics

    Science.gov (United States)

    April, Daniel; Bouchamma, Yamina

    2015-01-01

    A questionnaire was used to determine the individual and collective teacher supervision practices of school principals and vice-principals in Québec (n = 39) who participated in a research-action study on pedagogical supervision. These practices were then analyzed in terms of the principals' sociodemographic and socioprofessional characteristics…

  6. Advances in synthetic peptides reagent discovery

    Science.gov (United States)

    Adams, Bryn L.; Sarkes, Deborah A.; Finch, Amethist S.; Stratis-Cullum, Dimitra N.

    2013-05-01

    Bacterial display technology offers a number of advantages over competing display technologies (e.g, phage) for the rapid discovery and development of peptides with interaction targeted to materials ranging from biological hazards through inorganic metals. We have previously shown that discovery of synthetic peptide reagents utilizing bacterial display technology is relatively simple and rapid to make laboratory automation possible. This included extensive study of the protective antigen system of Bacillus anthracis, including development of discovery, characterization, and computational biology capabilities for in-silico optimization. Although the benefits towards CBD goals are evident, the impact is far-reaching due to our ability to understand and harness peptide interactions that are ultimately extendable to the hybrid biomaterials of the future. In this paper, we describe advances in peptide discovery including, new target systems (e.g. non-biological materials), advanced library development and clone analysis including integrated reporting.

  7. Supernovae Discovery Efficiency

    Science.gov (United States)

    John, Colin

    2018-01-01

    Abstract:We present supernovae (SN) search efficiency measurements for recent Hubble Space Telescope (HST) surveys. Efficiency is a key component to any search, and is important parameter as a correction factor for SN rates. To achieve an accurate value for efficiency, many supernovae need to be discoverable in surveys. This cannot be achieved from real SN only, due to their scarcity, so fake SN are planted. These fake supernovae—with a goal of realism in mind—yield an understanding of efficiency based on position related to other celestial objects, and brightness. To improve realism, we built a more accurate model of supernovae using a point-spread function. The next improvement to realism is planting these objects close to galaxies and of various parameters of brightness, magnitude, local galactic brightness and redshift. Once these are planted, a very accurate SN is visible and discoverable by the searcher. It is very important to find factors that affect this discovery efficiency. Exploring the factors that effect detection yields a more accurate correction factor. Further inquires into efficiency give us a better understanding of image processing, searching techniques and survey strategies, and result in an overall higher likelihood to find these events in future surveys with Hubble, James Webb, and WFIRST telescopes. After efficiency is discovered and refined with many unique surveys, it factors into measurements of SN rates versus redshift. By comparing SN rates vs redshift against the star formation rate we can test models to determine how long star systems take from the point of inception to explosion (delay time distribution). This delay time distribution is compared to SN progenitors models to get an accurate idea of what these stars were like before their deaths.

  8. Teaching Principal Components Using Correlations.

    Science.gov (United States)

    Westfall, Peter H; Arias, Andrea L; Fulton, Lawrence V

    2017-01-01

    Introducing principal components (PCs) to students is difficult. First, the matrix algebra and mathematical maximization lemmas are daunting, especially for students in the social and behavioral sciences. Second, the standard motivation involving variance maximization subject to unit length constraint does not directly connect to the "variance explained" interpretation. Third, the unit length and uncorrelatedness constraints of the standard motivation do not allow re-scaling or oblique rotations, which are common in practice. Instead, we propose to motivate the subject in terms of optimizing (weighted) average proportions of variance explained in the original variables; this approach may be more intuitive, and hence easier to understand because it links directly to the familiar "R-squared" statistic. It also removes the need for unit length and uncorrelatedness constraints, provides a direct interpretation of "variance explained," and provides a direct answer to the question of whether to use covariance-based or correlation-based PCs. Furthermore, the presentation can be made without matrix algebra or optimization proofs. Modern tools from data science, including heat maps and text mining, provide further help in the interpretation and application of PCs; examples are given. Together, these techniques may be used to revise currently used methods for teaching and learning PCs in the behavioral sciences.

  9. Principal component regression analysis with SPSS.

    Science.gov (United States)

    Liu, R X; Kuang, J; Gong, Q; Hou, X L

    2003-06-01

    The paper introduces all indices of multicollinearity diagnoses, the basic principle of principal component regression and determination of 'best' equation method. The paper uses an example to describe how to do principal component regression analysis with SPSS 10.0: including all calculating processes of the principal component regression and all operations of linear regression, factor analysis, descriptives, compute variable and bivariate correlations procedures in SPSS 10.0. The principal component regression analysis can be used to overcome disturbance of the multicollinearity. The simplified, speeded up and accurate statistical effect is reached through the principal component regression analysis with SPSS.

  10. School Principals' Assumptions about Human Nature: Implications for Leadership in Turkey

    Science.gov (United States)

    Sabanci, Ali

    2008-01-01

    This article considers principals' assumptions about human nature in Turkey and the relationship between the assumptions held and the leadership style adopted in schools. The findings show that school principals hold Y-type assumptions and prefer a relationship-oriented style in their relations with assistant principals. However, both principals…

  11. Discovery of Fullerenes

    Indian Academy of Sciences (India)

    ... Journal of Science Education; Volume 2; Issue 1. Discovery of Fullerenes Giving a New Shape to Carbon Chemistry. Rathna Ananthaiah. Research News Volume 2 Issue 1 January 1997 pp 68-73. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/002/01/0068-0073 ...

  12. Landmark Discoveries in Neurosciences

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 11. Landmark Discoveries in Neurosciences. Niranjan Kambi Neeraj Jain. General Article Volume 17 Issue 11 November 2012 pp 1054-1064. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. The discovery of fission

    International Nuclear Information System (INIS)

    McKay, H.A.C.

    1978-01-01

    In this article by the retired head of the Separation Processes Group of the Chemistry Division, Atomic Energy Research Establishment, Harwell, U.K., the author recalls what he terms 'an exciting drama, the unravelling of the nature of the atomic nucleus' in the years before the Second World War, including the discovery of fission. 12 references. (author)

  14. Nonlinear principal component analysis and its applications

    CERN Document Server

    Mori, Yuichi; Makino, Naomichi

    2016-01-01

    This book expounds the principle and related applications of nonlinear principal component analysis (PCA), which is useful method to analyze mixed measurement levels data. In the part dealing with the principle, after a brief introduction of ordinary PCA, a PCA for categorical data (nominal and ordinal) is introduced as nonlinear PCA, in which an optimal scaling technique is used to quantify the categorical variables. The alternating least squares (ALS) is the main algorithm in the method. Multiple correspondence analysis (MCA), a special case of nonlinear PCA, is also introduced. All formulations in these methods are integrated in the same manner as matrix operations. Because any measurement levels data can be treated consistently as numerical data and ALS is a very powerful tool for estimations, the methods can be utilized in a variety of fields such as biometrics, econometrics, psychometrics, and sociology. In the applications part of the book, four applications are introduced: variable selection for mixed...

  15. Workshop on Discovery Lessons-Learned

    Science.gov (United States)

    Saunders, M. (Editor)

    1995-01-01

    As part of the Discovery Program's continuous improvement effort, a Discovery Program Lessons-Learned workshop was designed to review how well the Discovery Program is moving toward its goal of providing low-cost research opportunities to the planetary science community while ensuring continued U.S. leadership in solar system exploration. The principal focus of the workshop was on the recently completed Announcement of Opportunity (AO) cycle, but the program direction and program management were also open to comment. The objective of the workshop was to identify both the strengths and weaknesses of the process up to this point, with the goal of improving the process for the next AO cycle. The process for initializing the workshop was to solicit comments from the communities involved in the program and to use the feedback as the basis for establishing the workshop agenda. The following four sessions were developed after reviewing and synthesizing both the formal feedback received and informal feedback obtained during discussions with various participants: (1) Science and Return on Investment; (2) Technology vs. Risk; Mission Success and Other Factors; (3) Cost; and (4) AO.AO Process Changes and Program Management.

  16. Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis

    DEFF Research Database (Denmark)

    Skov, V.; Thomassen, Mads; Kruse, T.A.

    2012-01-01

    The recent discovery of the Janus activating kinase 2 V617F mutation in most patients with polycythemia vera (PV) and half of those with essential thrombocythemia (ET) and primary myelofibrosis (PMF) has favored the hypothesis of a biological continuum from ET over PV to PMF. We performed gene...... expression profiling of whole blood from control subjects (n = 21) and patients with ET (n = 19), PV (n = 41), and PMF (n = 9) using DNA microarrays. Applying an unsupervised method, principal component analysis, to search for patterns in the data, we demonstrated a separation of the four groups...... with biological relevant overlaps between the different entities. Moreover, the analysis separates Janus activating kinase 2-negative ET patients from Janus activating kinase 2-positive ET patients. Functional annotation analysis demonstrates that clusters of gene ontology terms related to inflammation, immune...

  17. Discovery and Innovation: Contact

    African Journals Online (AJOL)

    Principal Contact. Prof. Keto Mshigeni Editor-in-Chief Academy Science Publishers. PO Box 14798-00200. Nairobi. Kenya. Phone: 254 (20) 884401-5. Fax: 254 (20) 884406. Email: aas@aasciences.org. Support Contact. Prof. Keto Mshigeni Email: aas@aasciences.org. ISSN: 1015-079X. AJOL African Journals Online.

  18. Sequencing, de novo assembly and characterization of the spotted scat Scatophagus argus (Linnaeus 1766) transcriptome for discovery of reproduction related genes and SSRs

    Science.gov (United States)

    Yang, Wei; Chen, Huapu; Cui, Xuefan; Zhang, Kewei; Jiang, Dongneng; Deng, Siping; Zhu, Chunhua; Li, Guangli

    2017-09-01

    Spotted scat (Scatophagus argus) is an economically important farmed fish, particularly in East and Southeast Asia. Because there has been little research on reproductive development and regulation in this species, the lack of a mature artificial reproduction technology remains a barrier for the sustainable development of the aquaculture industry. More genetic and genomic background knowledge is urgently needed for an in-depth understanding of the molecular mechanism of reproductive process and identification of functional genes related to sexual differentiation, gonad maturation and gametogenesis. For these reasons, we performed transcriptomic analysis on spotted scat using a multiple tissue sample mixing strategy. The Illumina RNA sequencing generated 118 510 486 raw reads. After trimming, de novo assembly was performed and yielded 99 888 unigenes with an average length of 905.75 bp. A total of 45 015 unigenes were successfully annotated to the Nr, Swiss-Prot, KOG and KEGG databases. Additionally, 23 783 and 27 183 annotated unigenes were assigned to 56 Gene Ontology (GO) functional groups and 228 KEGG pathways, respectively. Subsequently, 2 474 transcripts associated with reproduction were selected using GO term and KEGG pathway assignments, and a number of reproduction-related genes involved in sex differentiation, gonad development and gametogenesis were identified. Furthermore, 22 279 simple sequence repeat (SSR) loci were discovered and characterized. The comprehensive transcript dataset described here greatly increases the genetic information available for spotted scat and contributes valuable sequence resources for functional gene mining and analysis. Candidate transcripts involved in reproduction would make good starting points for future studies on reproductive mechanisms, and the putative sex differentiation-related genes will be helpful for sex-determining gene identification and sex-specific marker isolation. Lastly, the SSRs can serve as marker

  19. From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.

    Science.gov (United States)

    Taché, Yvette; Brunnhuber, Stefan

    2008-12-01

    Selye pioneered the concept of biological stress in 1936, culminating in the identification of the corticotropin-releasing factor (CRF) signaling pathways by Vale's group in the last two decades. The characterization of the 41 amino-acid CRF and other peptide members of the mammalian CRF family, urocortin 1, urocortin 2, and urocortin 3, and the cloning of CRF(1) and CRF(2) receptors, which display distinct affinity for CRF ligands, combined with the development of selective CRF receptor antagonists enable us to unravel the importance of CRF(1) receptor in the stress-related endocrine (activation of pituitary-adrenal axis), behavioral (anxiety/depression, altered feeding), autonomic (activation of sympathetic nervous system), and immune responses. The activation of CRF(1) receptors is also one of the key mechanisms through which various stressors impact the gut to stimulate colonic propulsive motor function and to induce hypersensitivity to colorectal distension as shown by the efficacy of the CRF(1) receptor antagonists in blunting these stress-related components. The importance of CRF(1) signaling pathway in the visceral response to stress in experimental animals provided new therapeutic approaches for treatment of functional bowel disorder such as irritable bowel syndrome, a multifactor functional disorder characterized by altered bowel habits and visceral pain, for which stress has been implicated in the pathophysiology and is associated with anxiety-depression in a subset of patients.

  20. Chance, creativity, and the discovery of the nerve growth factor.

    Science.gov (United States)

    de Romo, Ana Cecilia Rodríguez

    2007-01-01

    This essay analyzes the history of the Nerve Growth Factor (NGF) discovery, relating some of the principles of the theory of scientific creativity to the cognitive and personal qualities of the scientists that participated in the discovery, particularly Rita Levi-Montalcini and Viktor Hamburger. The discovery of NGF is especially attractive for the history of science as it involves chance, luck, creativity, and some extraordinary scientists.

  1. The neutron discovery

    International Nuclear Information System (INIS)

    Six, J.

    1987-01-01

    The neutron: who had first the idea, who discovered it, who established its main properties. To these apparently simple questions, multiple answers exist. The progressive discovery of the neutron is a marvellous illustration of some characteristics of the scientific research, where the unforeseen may be combined with the expected. This discovery is replaced in the context of the 1930's scientific effervescence that succeeded the revolutionary introduction of quantum mechanics. This book describes the works of Bothe, the Joliot-Curie and Chadwick which led to the neutron in an unexpected way. A historical analysis allows to give a new interpretation on the hypothesis suggested by the Joliot-Curie. Some texts of these days will help the reader to revive this fascinating story [fr

  2. Discovery of charm

    Energy Technology Data Exchange (ETDEWEB)

    Goldhaber, G.

    1984-11-01

    In my talk I will cover the period 1973 to 1976 which saw the discoveries of the J/psi and psi' resonances and most of the Psion spectroscopy, the tau lepton and the D/sup 0/,D/sup +/ charmed meson doublet. Occasionally I will refer briefly to more recent results. Since this conference is on the history of the weak-interactions I will deal primarily with the properties of naked charm and in particular the weakly decaying doublet of charmed mesons. Most of the discoveries I will mention were made with the SLAC-LBL Magnetic Detector or MARK I which we operated at SPEAR from 1973 to 1976. 27 references.

  3. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  4. Fine definition of the pedigree haplotypes of closely related rice cultivars by means of genome-wide discovery of single-nucleotide polymorphisms

    Directory of Open Access Journals (Sweden)

    Shibaya Taeko

    2010-04-01

    Full Text Available Abstract Background To create useful gene combinations in crop breeding, it is necessary to clarify the dynamics of the genome composition created by breeding practices. A large quantity of single-nucleotide polymorphism (SNP data is required to permit discrimination of chromosome segments among modern cultivars, which are genetically related. Here, we used a high-throughput sequencer to conduct whole-genome sequencing of an elite Japanese rice cultivar, Koshihikari, which is closely related to Nipponbare, whose genome sequencing has been completed. Then we designed a high-throughput typing array based on the SNP information by comparison of the two sequences. Finally, we applied this array to analyze historical representative rice cultivars to understand the dynamics of their genome composition. Results The total 5.89-Gb sequence for Koshihikari, equivalent to 15.7× the entire rice genome, was mapped using the Pseudomolecules 4.0 database for Nipponbare. The resultant Koshihikari genome sequence corresponded to 80.1% of the Nipponbare sequence and led to the identification of 67 051 SNPs. A high-throughput typing array consisting of 1917 SNP sites distributed throughout the genome was designed to genotype 151 representative Japanese cultivars that have been grown during the past 150 years. We could identify the ancestral origin of the pedigree haplotypes in 60.9% of the Koshihikari genome and 18 consensus haplotype blocks which are inherited from traditional landraces to current improved varieties. Moreover, it was predicted that modern breeding practices have generally decreased genetic diversity Conclusions Detection of genome-wide SNPs by both high-throughput sequencer and typing array made it possible to evaluate genomic composition of genetically related rice varieties. With the aid of their pedigree information, we clarified the dynamics of chromosome recombination during the historical rice breeding process. We also found several

  5. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    also contributed to the discovery of new isotopes. More recently, most of the very neutron- rich isotopes have been discovered by projectile fission. After a brief summary of the discovery of fission process itself, these production mechanisms will be discussed. The paper concludes with an outlook on future discoveries of ...

  6. Recent Discoveries and Bible Translation.

    Science.gov (United States)

    Harrelson, Walter

    1990-01-01

    Discusses recent discoveries for "Bible" translation with a focus on the "Dead Sea Scrolls." Examines recent discoveries that provide direct support for alternative reading of biblical passages and those discoveries that have contributed additional insight to knowledge of cultural practices, especially legal and religious…

  7. Fateful discovery almost forgotten

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    The paper reviews the discovery of the fission of uranium, which took place fifty years ago. A description is given of the work of Meitner and Frisch in interpreting the Fermi data on the bombardment of uranium nuclei with neutrons, i.e. proposing fission. The historical events associated with the development and exploitation of uranium fission are described, including the Manhattan Project, Hiroshima and Nagasaki, Shippingport, and Chernobyl. (U.K.)

  8. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  9. Discovery of TUG-770

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth; Hansen, Steffen Vissing Fahnøe; Urban, Christian

    2013-01-01

    Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical...... and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing....

  10. Discovery concepts for Mars

    Science.gov (United States)

    Luhmann, J. G.; Russell, C. T.; Brace, L. H.; Nagy, A. F.; Jakosky, B. M.; Barth, C. A.; Waite, J. H.

    1992-01-01

    Two focused Mars missions that would fit within the guidelines for the proposed Discovery line are discussed. The first mission would deal with the issue of the escape of the atmosphere (Mars') to space. A complete understanding of this topic is crucial to deciphering the evolution of the atmosphere, climate change, and volatile inventories. The second mission concerns the investigation of remanent magnetization of the crust and its relationship to the ionosphere and the atmosphere.

  11. A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes: DISCOVERY OF P450-TYPE HYDROPEROXIDE LYASE ACTIVITY IN A CATALASE.

    Science.gov (United States)

    Teder, Tarvi; Lõhelaid, Helike; Boeglin, William E; Calcutt, Wade M; Brash, Alan R; Samel, Nigulas

    2015-08-07

    In corals a catalase-lipoxygenase fusion protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,14-eicosatetraenoic acid from which arise cyclopentenones such as the prostanoid-related clavulones. Recently we cloned two catalase-lipoxygenase fusion protein genes (a and b) from the coral Capnella imbricata, form a being an allene oxide synthase and form b giving uncharacterized polar products (Lõhelaid, H., Teder, T., Tõldsepp, K., Ekins, M., and Samel, N. (2014) PloS ONE 9, e89215). Here, using HPLC-UV, LC-MS, and NMR methods, we identify a novel activity of fusion protein b, establishing its role in cleaving the lipoxygenase product 8R-hydroperoxy-eicosatetraenoic acid into the short-chain aldehydes (5Z)-8-oxo-octenoic acid and (3Z,6Z)-dodecadienal; these primary products readily isomerize in an aqueous medium to the corresponding 6E- and 2E,6Z derivatives. This type of enzymatic cleavage, splitting the carbon chain within the conjugated diene of the hydroperoxide substrate, is known only in plant cytochrome P450 hydroperoxide lyases. In mechanistic studies using (18)O-labeled substrate and incubations in H2(18)O, we established synthesis of the C8-oxo acid and C12 aldehyde with the retention of the hydroperoxy oxygens, consistent with synthesis of a short-lived hemiacetal intermediate that breaks down spontaneously into the two aldehydes. Taken together with our initial studies indicating differing gene regulation of the allene oxide synthase and the newly identified catalase-related hydroperoxide lyase and given the role of aldehydes in plant defense, this work uncovers a potential pathway in coral stress signaling and a novel enzymatic activity in the animal kingdom. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Perceived Educational Values of Omani School Principals

    Science.gov (United States)

    Al-Ani, Wajeha Thabit; Al-Harthi, Aisha Salim

    2017-01-01

    This qualitative study investigated the perceived educational values of Omani school principals. Data were collected using a semi-structured interview form which focused on the core values of school administration as perceived by a sample of 44 school principals; a focus group interview was also held. Data were analysed using Nvivo software. The…

  13. Evaluation Priorities of Students, Teachers, and Principals.

    Science.gov (United States)

    Nevo, David; Stufflebeam, Daniel L.

    The main purposes of this study were to identify the evaluation needs of students, teachers, and principals, and to develop recommendations for an evaluation system within the school building. Students, teachers, and principals were surveyed to depict the availability and importance of eight different categories of evaluative information derived…

  14. Principals' Knowledge of and Attitudes toward Inclusion.

    Science.gov (United States)

    Barnett, Carol; Monda-Amaya, Lisa E.

    1998-01-01

    A survey of 65 elementary, junior, and high school principals investigated attitudes toward and knowledge of inclusion. No clear definition of inclusion emerged, but principals generally viewed inclusion as most appropriate for students with mild disabilities. Also, results indicated that teachers were not adequately prepared to implement…

  15. Perceptions of Online Credentials for School Principals

    Science.gov (United States)

    Richardson, Jayson W.; McLeod, Scott; Dikkers, Amy Garrett

    2011-01-01

    Purpose: The purpose of this study is to investigate the perceptions of human resource directors in the USA about online credentials earned by K-12 school principals and principal candidates. Design/methodology/approach: In this mixed methods study, a survey was sent to a random sample of 500 human resource directors in K-12 school districts…

  16. Primary School Principals' Self-Monitoring Skills

    Science.gov (United States)

    Konan, Necdet

    2015-01-01

    The aim of the present study is to identify primary school principals' self-monitoring skills. The study adopted the general survey model and its population comprised primary school principals serving in the city of Diyarbakir, Turkey, while 292 of these constituted the sample. Self-Monitoring Scale was used as the data collection instrument. In…

  17. Should Principals Know More about Law?

    Science.gov (United States)

    Doctor, Tyrus L.

    2013-01-01

    Educational law is a critical piece of the education conundrum. Principals reference law books on a daily basis in order to address the wide range of complex problems in the school system. A principal's knowledge of law issues and legal decision-making are essential to provide effective feedback for a successful school.

  18. Integrating Technology: The Principals' Role and Effect

    Science.gov (United States)

    Machado, Lucas J.; Chung, Chia-Jung

    2015-01-01

    There are many factors that influence technology integration in the classroom such as teacher willingness, availability of hardware, and professional development of staff. Taking into account these elements, this paper describes research on technology integration with a focus on principals' attitudes. The role of the principal in classroom…

  19. Principal Prep for Common Core Gaining Traction

    Science.gov (United States)

    Gewertz, Catherine

    2012-01-01

    A year ago, top officials in the school leadership world were worried. It seemed to them that principals were being overlooked in national conversations about how to get educators ready for the Common Core State Standards. But that is changing. The past six months have seen a surge of activity to acquaint principals with the new standards and…

  20. New pulser for principal PO power

    International Nuclear Information System (INIS)

    Coudert, G.

    1984-01-01

    The pulser of the principal power of the PS is the unit that makes it possible to generate the reference function of the voltage of the principal magnet. This function depends on time and on the magnetic field of the magnet. It also generates various synchronization and reference pulses

  1. An Examination of Principal Job Satisfaction

    Science.gov (United States)

    Pengilly, Michelle M.

    2010-01-01

    As education continues to succumb to deficits in budgets and increasingly high levels of student performance to meet the federal and state mandates, the quest to sustain and retain successful principals is imperative. The National Association of School Boards (1999) portrays effective principals as "linchpins" of school improvement and…

  2. A Latina Principal Leading for Social Justice

    Science.gov (United States)

    Hernandez, Frank; Murakami, Elizabeth T.; Cerecer, Patricia Quijada

    2014-01-01

    In this study, the role that racial identity plays among Latina school principals is examined through a case study of a principal in a K-3 elementary school. Based on a Latina/o critical race framework and a phenomenological research approach, the study explores the degree to which having a strong understanding of one's racial identity formation…

  3. Building Leadership Capacity to Support Principal Succession

    Science.gov (United States)

    Escalante, Karen Elizabeth

    2016-01-01

    This study applies transformational leadership theory practices, specifically inspiring a shared vision, modeling the way and enabling others to act to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the dearth of K-12 principals. The purpose of this study was to discover how one…

  4. The Succession of a School Principal.

    Science.gov (United States)

    Fauske, Janice R.; Ogawa, Rodney T.

    Applying theory from organizational and cultural perspectives to succession of principals, this study observes and records the language and culture of a small suburban elementary school. The study's procedures included analyses of shared organizational understandings as well as identification of the principal's influence on the school. Analyses of…

  5. Balancing Acts: Women Principals at Work.

    Science.gov (United States)

    Smulyan, Lisa

    This book uses life history and ethnography to examine the lives and work of three female elementary school principals and highlights their daily use of personal and professional skills. The principals' personal backgrounds and their effect on their work are examined within the community they serve, their school, and the historical and social…

  6. Social Media Strategies for School Principals

    Science.gov (United States)

    Cox, Dan; McLeod, Scott

    2014-01-01

    The purpose of this qualitative study was to describe, analyze, and interpret the experiences of school principals who use multiple social media tools with stakeholders as part of their comprehensive communications practices. Additionally, it examined why school principals have chosen to communicate with their stakeholders through social media.…

  7. Geographical Distribution of Principals in Israeli Schools

    Science.gov (United States)

    Lebental, Dana M.

    2015-01-01

    This quantitative investigation focuses on women high school principals at Jewish secular schools throughout Israel. Despite challenges, Israeli women have succeeded in obtaining over half of the principal positions at Jewish secular high schools, but the degree to which there is equal gender access to leadership roles in the school system remains…

  8. Principals: Human Capital Managers at Every School

    Science.gov (United States)

    Kimball, Steven M.

    2011-01-01

    Being a principal is more than just being an instructional leader. Principals also must manage their schools' teaching talent in a strategic way so that it is linked to school instructional improvement strategies, to the competencies needed to enact the strategies, and to success in boosting student learning. Teacher acquisition and performance…

  9. New Principals' Perspectives of Their Multifaceted Roles

    Science.gov (United States)

    Gentilucci, James L.; Denti, Lou; Guaglianone, Curtis L.

    2013-01-01

    This study utilizes Symbolic Interactionism to explore perspectives of neophyte principals. Findings explain how these perspectives are modified through complex interactions throughout the school year, and they also suggest preparation programs can help new principals most effectively by teaching "soft" skills such as active listening…

  10. The Relationship between Principals' Managerial Approaches and ...

    African Journals Online (AJOL)

    Nekky Umera

    administered questionnaire from a sample of 211 teachers, 28 principals and .... education. For example, death of students in the wake of school violence is a loss of valuable investment in human capital. On the other hand, destruction ... principal's attitude, gender qualifications, and leadership experience (Green,. 1999 ...

  11. Principal G-bundles on nodal curves

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    If Y is reducible these notions depend on parameters a = (a1,...,aI ). The study of G-bundles on Y is done by extending the notion of (generalized) parabolic vector bundles [U1] to generalized parabolic principal G-bundles (called GPGs in short) on the curve C and using the correspondence between them and principal ...

  12. Assistant Principals and Reform: A Socialization Paradox?

    Science.gov (United States)

    Best, Marguerita L.

    2013-01-01

    Framed in the critical race theory of structuration (CRTS), this sequential explanatory mixed methods study seeks to identify the socialization practices by examining the realities of practices of assistant principals and the ways in which they impact the disciplinary actions of assistant principals at middle and high schools. The mixed methods…

  13. De novo sequencing and comparative transcriptome analysis of white petals and red labella in Phalaenopsis for discovery of genes related to flower color and floral differentation

    Directory of Open Access Journals (Sweden)

    Yuxia Yang

    2014-09-01

    Full Text Available Phalaenopsis is one of the world’s most popular and important epiphytic monopodial orchids. The extraordinary floral diversity of Phalaenopsis is a reflection of its evolutionary success. As a consequence of this diversity, and of the complexity of flower color development in Phalaenopsis, this species is a valuable research material for developmental biology studies. Nevertheless, research on the molecular mechanisms underlying flower color and floral organ formation in Phalaenopsis is still in the early phases. In this study, we generated large amounts of data from Phalaenopsis flowers by combining Illumina sequencing with differentially expressed gene (DEG analysis. We obtained 37 723 and 34 020 unigenes from petals and labella, respectively. A total of 2736 DEGs were identified, and the functions of many DEGs were annotated by BLAST-searching against several public databases. We mapped 837 up-regulated DEGs (432 from petals and 405 from labella to 102 Kyoto Encyclopedia of Genes and Genomes pathways. Almost all pathways were represented in both petals (102 pathways and labella (99 pathways. DEGs involved in energy metabolism were significantly differentially distributed between labella and petals, and various DEGs related to flower color and floral differentiation were found in the two organs. Interestingly, we also identified genes encoding several key enzymes involved in carotenoid synthesis. These genes were differentially expressed between petals and labella, suggesting that carotenoids may influence Phalaenopsis flower color. We thus conclude that a combination of anthocyanins and/or carotenoids determine flower color formation in Phalaenopsis. These results broaden our understanding of the mechanisms controlling flower color and floral organ differentiation in Phalaenopsis and other orchids.

  14. Elementary school principals' perceptions of childhood obesity.

    Science.gov (United States)

    Price, J H; Desmond, S M; Stelzer, C M

    1987-11-01

    This survey assessed school principals' perceptions regarding childhood obesity and the schools' role in dealing with the problem. A randomly selected group of 300 school principals was obtained from the National Association of Elementary School Principals; 227 (76%) administrators returned the questionnaire. Fifty-one percent of the principals believed normal weight was important to child health. Although 35% believed schools were not doing enough to alleviate childhood obesity, responses suggested principals oppose schools becoming obesity treatment centers. They do not believe teachers or parents would support such programs. They perceived the school's role to be educational and referral in nature. However, they supported elimination of "junk food" machines (71%) and provision of low calorie lunches (60%). They believed school nurses play the most important role in treating childhood obesity at school.

  15. A genome-wide transcriptome map of pistachio (Pistacia vera L.) provides novel insights into salinity-related genes and marker discovery.

    Science.gov (United States)

    Moazzzam Jazi, Maryam; Seyedi, Seyed Mahdi; Ebrahimie, Esmaeil; Ebrahimi, Mansour; De Moro, Gianluca; Botanga, Christopher

    2017-08-17

    of NCED3 and SOS1 genes were observed between salt-sensitive and salt-tolerant cultivars. This study, as the first report on the whole transcriptome survey of P. vera, provides important resources and paves the way for functional and comparative genomic studies on this major tree to discover the salinity tolerance-related markers and stress response mechanisms for breeding of new pistachio cultivars with more salinity tolerance.

  16. Influence of Principals' Administrative Style on the Job Performance ...

    African Journals Online (AJOL)

    The objective was to evaluate the administrative style of secondary school principals in relation to teachers' job performance in Cross River State, Nigeria. A total of four hundred (400) teachers and one thousand two hundred (1200) students were randomly sampled for the study, using Ex-post facto research design with ...

  17. Primary Principals' Leadership Styles, School Organizational Health and Workplace Bullying

    Science.gov (United States)

    Cemaloglu, Necati

    2011-01-01

    Purpose: The purpose of this paper is to determine the relationships between leadership styles of primary school principals and organizational health and bullying. Design/methodology/approach: Two hypotheses were formulated in relation to the research. Three instruments were used--a multi-level questionnaire for measuring leadership, an…

  18. Sustainable School Improvement: Suburban Elementary Principals' Capacity Building

    Science.gov (United States)

    Clark, Alison J.

    2017-01-01

    The increase of intense pressures to ensure long-term education reforms have created a challenge for school leaders as they direct and nurture the abilities of others. The purpose of this research was to understand and describe suburban elementary principals' practices and perceptions as change leaders related to capacity building through the…

  19. IN-SERVICE EDUCATION OF ELEMENTARY SCHOOL PRINCIPALS.

    Science.gov (United States)

    PHARIS, WILLIAM L.

    THE NEED FOR CONTINUING EDUCATION OF THE ELEMENTARY SCHOOL PRINCIPAL IS EMPHASIZED, ESPECIALLY AS IT RELATES TO SOCIAL PROBLEMS (POPULATION EXPLOSION, URBANIZATION, RESOURCE DISTRIBUTION, IMBALANCE, AND POPULATION MOBILITY) WHOSE EVENTUAL SOLUTIONS DEPEND UPON EDUCATION. PARTICULAR AREAS OF EDUCATIONAL CHANGE REQUIRING INSERVICE EDUCATION OF…

  20. Using Subjective Teacher Evaluations to Examine Principals' Personnel Management

    Science.gov (United States)

    Master, Benjamin

    2013-01-01

    Teacher evaluation is at the center of current education policy reform. Most evaluation systems rely at least in part on principals' assessments of teachers, and their discretionary judgments carry substantial weight. However, we know relatively little about what they value when determining evaluations and high stakes personnel decisions. The…

  1. Stress in School Administration: Coping Tips for Principals

    Science.gov (United States)

    Sogunro, Olusegun Agboola

    2012-01-01

    With the need for rapid school reform amid changes in socioeconomic and political situations, evidence abounds that today's school principals operate in a stress-strained environment. Participants of this study identified at least a form of stress on the job. More than 96% claimed to have experienced work-related stress at a level they believed…

  2. Hidden symmetries of the Principal Chiral Model unveiled

    International Nuclear Information System (INIS)

    Devchand, C.; Schiff, J.

    1996-12-01

    By relating the two-dimensional U(N) Principal Chiral Model to a Simple linear system we obtain a free-field parametrization of solutions. Obvious symmetry transformations on the free-field data give symmetries of the model. In this way all known 'hidden symmetries' and Baecklund transformations, as well as a host of new symmetries, arise. (author). 21 refs

  3. Supervision Duty of School Principals

    Directory of Open Access Journals (Sweden)

    Kürşat YILMAZ

    2009-04-01

    Full Text Available Supervision by school administrators is becoming more and more important. The change in the roles ofschool administrators has a great effect on that increase. At present, school administrators are consideredmore than as technical directors, but as instructional leaders. This increased the importance of schooladministrators’ expected supervision acts. In this respect, the aim of this study is to make a conceptualanalysis about school administrators’ supervision duties. For this reason, a literature review related withsupervision and contemporary supervision approaches was done, and the official documents concerningsupervision were examined. As a result, it can be said that school administrators’ supervision duties havebecome very important. And these duties must certainly be carried out by school administrators.

  4. Bioenergy Knowledge Discovery Framework (KDF) Fact Sheet

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-07-29

    The Bioenergy Knowledge Discovery Framework (KDF) is an online collaboration and geospatial analysis tool that allows researchers, policymakers, and investors to explore and engage the latest bioenergy research. This publication describes how the KDF harnesses Web 2.0 and social networking technologies to build a collective knowledge system that facilitates collaborative production, integration, and analysis of bioenergy-related information.

  5. 36 CFR 1150.63 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... satisfactory to the judge, the judge may decide the fact or issue relating to the material requested to be... appropriate circumstances, but not as a matter of course, the judge may entertain motions for permission for... for discovery shall be granted only to the extent and upon such terms as the judge in his/her...

  6. Cognitive Neuroscience Discoveries and Educational Practices

    Science.gov (United States)

    Sylwester, Robert

    2006-01-01

    In this article, the author describes seven movement-related areas of cognitive neuroscience research that will play key roles in shifting the current behavioral orientation of teaching and learning to an orientation that also incorporates cognitive neuroscience discoveries. These areas of brain research include: (1) mirroring system; (2) plastic…

  7. Social Relationship Discovery Via Call Records

    Directory of Open Access Journals (Sweden)

    Zhao Wen-Zhe

    2017-01-01

    Full Text Available Telecom users constitute a huge, but relatively sparse social network. Community discovery has been a research topic of data mining. Traditional algorithms are greatly influenced by outliers. This paper presents a new algorithm based on social triangle theory. Experiments show that the new algorithm is effective.

  8. Sparse Principal Component Analysis in Medical Shape Modeling

    DEFF Research Database (Denmark)

    Sjöstrand, Karl; Stegmann, Mikkel Bille; Larsen, Rasmus

    2006-01-01

    Principal component analysis (PCA) is a widely used tool in medical image analysis for data reduction, model building, and data understanding and exploration. While PCA is a holistic approach where each new variable is a linear combination of all original variables, sparse PCA (SPCA) aims...... analysis in medicine. Results for three different data sets are given in relation to standard PCA and sparse PCA by simple thresholding of sufficiently small loadings. Focus is on a recent algorithm for computing sparse principal components, but a review of other approaches is supplied as well. The SPCA...

  9. Tables of the principal unitary representations of Fedorov groups

    CERN Document Server

    Faddeyev, D K

    1961-01-01

    Tables of the Principal Unitary Representations of Fedorov Groups contains tables of all the principal representations of Fedorov groups from which all irreducible unitary representations can be obtained with the help of some standard operations. The work originated at a seminar on mathematical crystallography held in 1952-1953 at the Faculty of Mathematics and Mechanics of the Leningrad State University. The book is divided into two parts. The first part discusses the relation between the theory of representations and the generalized Fedorov groups in Shubnikov's sense. It shows that all un

  10. Principal Self-Efficacy and Work Engagement: Assessing a Norwegian Principal Self-Efficacy Scale

    Science.gov (United States)

    Federici, Roger A.; Skaalvik, Einar M.

    2011-01-01

    One purpose of the present study was to develop and test the factor structure of a multidimensional and hierarchical Norwegian Principal Self-Efficacy Scale (NPSES). Another purpose of the study was to investigate the relationship between principal self-efficacy and work engagement. Principal self-efficacy was measured by the 22-item NPSES. Work…

  11. Principal Time Management Skills: Explaining Patterns in Principals' Time Use, Job Stress, and Perceived Effectiveness

    Science.gov (United States)

    Grissom, Jason A.; Loeb, Susanna; Mitani, Hajime

    2015-01-01

    Purpose: Time demands faced by school principals make principals' work increasingly difficult. Research outside education suggests that effective time management skills may help principals meet job demands, reduce job stress, and improve their performance. The purpose of this paper is to investigate these hypotheses. Design/methodology/approach:…

  12. Aspiring Principals' Perception of the Challenges of Beginning Principals and the Support That They Need

    Science.gov (United States)

    Ng, Pak Tee

    2015-01-01

    This paper presents the results of an exploratory research project about the perception of aspiring principals regarding the challenges of beginning principals and the support that they need. These aspiring principals are participants on the Leaders in Education Programme (LEP) in Singapore. According to the research findings, the LEP participants…

  13. Bioinformatics for discovery of microbiome variation

    DEFF Research Database (Denmark)

    Brejnrod, Asker Daniel

    two conditions. The purpose is to assess the false discovery rate, recovery of truly differential abundant bacteria and the impact of beta diversity exploration strategies commonly used in microbiome research. We assess these differences by simulation and by making biological assumptions about...... of various molecular methods to build hypotheses about the impact of a copper contaminated soil. The introduction is a broad introduction to the field of microbiome research with a focus on the technologies that enable these discoveries and how some of the broader issues have related to this thesis...... 1 ,“Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies”, benchmarked the performance of a variety of popular statistical methods for discovering differentially abundant bacteria . between...

  14. Longitudinal functional principal component modelling via Stochastic Approximation Monte Carlo

    KAUST Repository

    Martinez, Josue G.

    2010-06-01

    The authors consider the analysis of hierarchical longitudinal functional data based upon a functional principal components approach. In contrast to standard frequentist approaches to selecting the number of principal components, the authors do model averaging using a Bayesian formulation. A relatively straightforward reversible jump Markov Chain Monte Carlo formulation has poor mixing properties and in simulated data often becomes trapped at the wrong number of principal components. In order to overcome this, the authors show how to apply Stochastic Approximation Monte Carlo (SAMC) to this problem, a method that has the potential to explore the entire space and does not become trapped in local extrema. The combination of reversible jump methods and SAMC in hierarchical longitudinal functional data is simplified by a polar coordinate representation of the principal components. The approach is easy to implement and does well in simulated data in determining the distribution of the number of principal components, and in terms of its frequentist estimation properties. Empirical applications are also presented.

  15. Ionospheric Anomalies Related to the (M = 7.3, August 27, 2012, Puerto Earthquake, (M = 6.8, August 30, 2012 Jan Mayen Island Earthquake, and (M = 7.6, August 31, 2012, Philippines Earthquake: Two-Dimensional Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Jyh-Woei Lin

    2013-01-01

    Full Text Available Two-dimensional principal component analysis (2DPCA and principal component analysis (PCA are used to examine the ionospheric total electron content (TEC data during the time period from 00:00 on August 21 to 12: 45 on August 31 (UT, which are 10 days before the M = 7.6 Philippines earthquake at 12:47:34 on August 31, 2012 (UT with the depth at 34.9 km. From the results by using 2DPCA, a TEC precursor of Philippines earthquake is found during the time period from 4:25 to 4:40 on August 28, 2012 (UT with the duration time of at least 15 minutes. Another earthquake-related TEC anomaly is detectable for the time period from 04:35 to 04:40 on August 27, 2012 (UT with the duration time of at least 5 minutes during the Puerto earthquake at 04: 37:20 on August 27, 2012 (UT (Mw = 7.3 with the depth at 20.3 km. The precursor of the Puerto earthquake is not detectable. TEC anomaly is not to be found related to the Jan Mayen Island earthquake (Mw = 6.8 at 13:43:24 on August 30, 2012 (UT. These earthquake-related TEC anomalies are detectable by using 2DPCA rather than PCA. They are localized nearby the epicenters of the Philippines and Puerto earthquakes.

  16. Automated Supernova Discovery (Abstract)

    Science.gov (United States)

    Post, R. S.

    2015-12-01

    (Abstract only) We are developing a system of robotic telescopes for automatic recognition of Supernovas as well as other transient events in collaboration with the Puckett Supernova Search Team. At the SAS2014 meeting, the discovery program, SNARE, was first described. Since then, it has been continuously improved to handle searches under a wide variety of atmospheric conditions. Currently, two telescopes are used to build a reference library while searching for PSN with a partial library. Since data is taken every night without clouds, we must deal with varying atmospheric and high background illumination from the moon. Software is configured to identify a PSN, reshoot for verification with options to change the run plan to acquire photometric or spectrographic data. The telescopes are 24-inch CDK24, with Alta U230 cameras, one in CA and one in NM. Images and run plans are sent between sites so the CA telescope can search while photometry is done in NM. Our goal is to find bright PSNs with magnitude 17.5 or less which is the limit of our planned spectroscopy. We present results from our first automated PSN discoveries and plans for PSN data acquisition.

  17. Automatic Subspace Learning via Principal Coefficients Embedding.

    Science.gov (United States)

    Peng, Xi; Lu, Jiwen; Yi, Zhang; Yan, Rui

    2017-11-01

    In this paper, we address two challenging problems in unsupervised subspace learning: 1) how to automatically identify the feature dimension of the learned subspace (i.e., automatic subspace learning) and 2) how to learn the underlying subspace in the presence of Gaussian noise (i.e., robust subspace learning). We show that these two problems can be simultaneously solved by proposing a new method [(called principal coefficients embedding (PCE)]. For a given data set , PCE recovers a clean data set from and simultaneously learns a global reconstruction relation of . By preserving into an -dimensional space, the proposed method obtains a projection matrix that can capture the latent manifold structure of , where is automatically determined by the rank of with theoretical guarantees. PCE has three advantages: 1) it can automatically determine the feature dimension even though data are sampled from a union of multiple linear subspaces in presence of the Gaussian noise; 2) although the objective function of PCE only considers the Gaussian noise, experimental results show that it is robust to the non-Gaussian noise (e.g., random pixel corruption) and real disguises; and 3) our method has a closed-form solution and can be calculated very fast. Extensive experimental results show the superiority of PCE on a range of databases with respect to the classification accuracy, robustness, and efficiency.

  18. Comparative Analysis of Principals' Management Strategies in ...

    African Journals Online (AJOL)

    It was recommended among others that principals of secondary schools should adopt all the management strategies in this study as this will improve school administration and consequently students‟ academic performance. Keywords: Management Strategies; Secondary Schools; Administrative Effectiveness ...

  19. First-Year Principal Encounters Homophobia

    Science.gov (United States)

    Retelle, Ellen

    2011-01-01

    A 1st-year principal encounters homonegativity and an ethical dilemma when she attempts to terminate a teacher because of the teacher's inadequate and ineffective teaching. The teacher responds by threatening to "out" Ms. L. to the parents.

  20. Principal Hawaiian Islands Geoid Heights (GEOID96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' geoid height grid for the Principal Hawaiian Islands is distributed as a GEOID96 model. The computation used 61,000 terrestrial and marine gravity data held...

  1. Nutrition education for adolescents: principals' views.

    Science.gov (United States)

    Lai-Yeung, Wai-Ling Theresa

    2011-01-01

    This study aimed to examine school principals' perceptions of the school environment in Hong Kong as a context for the dissemination of food knowledge and inculcation of healthy eating habits. A questionnaire survey was administered in secondary schools in Hong Kong to survey Principals' views of students' food choices, operation of the school tuck shop, and promotion of healthy eating at school. Questionnaires were disseminated to all the secondary schools offering Home Economics (300 out of 466), and 188 schools responded, making up a response rate of 63%. Collected data were analyzed using SPSS. Most of the schools (82%) claimed to have a food policy to monitor the operation of the school canteen, and about half (52%) asserted there were insufficient resources to promote healthy eating at school. Principals (88%) generally considered it not acceptable for the school tuck shop to sell junk food; however, 45% thought that banning junk food at school would not help students develop good eating habits. Only 4% of the principals believed nutrition education influenced eating habits; whereas the majority (94%) felt that even with acquisition of food knowledge, students may not be able to put theory into practice. Cooking skills were considered important but principals (92%) considered transmission of cooking skills the responsibility of the students' families. Most of the principals (94%) believed that school-family collaboration is important in promoting healthy eating. Further efforts should be made to enhance the effectiveness of school food policies and to construct healthy school environments in secondary schools.

  2. Representation Discovery using Harmonic Analysis

    CERN Document Server

    Mahadevan, Sridhar

    2008-01-01

    Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu

  3. Optogenetics enlightens neuroscience drug discovery.

    Science.gov (United States)

    Song, Chenchen; Knöpfel, Thomas

    2016-02-01

    Optogenetics - the use of light and genetics to manipulate and monitor the activities of defined cell populations - has already had a transformative impact on basic neuroscience research. Now, the conceptual and methodological advances associated with optogenetic approaches are providing fresh momentum to neuroscience drug discovery, particularly in areas that are stalled on the concept of 'fixing the brain chemistry'. Optogenetics is beginning to translate and transit into drug discovery in several key domains, including target discovery, high-throughput screening and novel therapeutic approaches to disease states. Here, we discuss the exciting potential of optogenetic technologies to transform neuroscience drug discovery.

  4. Predictors of timing of pregnancy discovery.

    Science.gov (United States)

    McCarthy, Molly; Upadhyay, Ushma; Biggs, M Antonia; Anthony, Renaisa; Holl, Jennifer; Roberts, Sarah Cm

    2018-04-01

    Earlier pregnancy discovery is important in the context of prenatal and abortion care. We evaluated characteristics associated with later pregnancy discovery among women seeking abortion care. Data come from a survey of women seeking abortion care at four family planning facilities in Utah. The participants completed a survey during the state-mandated abortion information visit they are required to complete prior to having an abortion. The outcome in this study was pregnancy discovery before versus after 6 weeks since respondents' last menstrual period (LMP). We used logistic regression to estimate the relationship between sociodemographic and health-related independent variables of interest and pregnancy discovery before versus after 6 weeks. Among the 458 women in the sample, 28% discovered their pregnancy later than 6 weeks since LMP. Most (n=366, 80%) knew the exact date of their LMP and a significant minority estimated it (n=92, 20%). Those who estimated the date of their LMP had higher odds of later pregnancy discovery than those who knew the exact date (adjusted odds ratio (aOR)=1.81[1.07-3.07]). Those who used illicit drugs weekly, daily, or almost daily had higher odds of later pregnancy discovery (aOR=6.33[2.44, 16.40]). Women who did not track their menstrual periods and those who frequently used drugs had higher odds of discovering their pregnancies later. Women who estimated the date of their LMP and who frequently used drugs may benefit from strategies to help them recognize their pregnancies earlier and link them to care when they discover their pregnancies later. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Discovery of neptunium

    International Nuclear Information System (INIS)

    Abelson, P.H.

    1990-01-01

    A number of distinguished scientists irradiated uranium with neutrons during 1934-1938. All were knowledgeable about the periodic table. They observed a number of beta-emitting activities that seemed to be from transuranic elements. They assumed that elements 93 and 94 would have chemical properties similar to rhenium and osmium respectively. In consequence discovery of fission and neptunium was delayed. After fission was finally demonstrated, a new search for element 93 was initiated by McMillan. He showed that when thin films of uranium are exposed to neutrons, high energy fission products leave the film - 23 minute and 2.3 day activities. The 23 minute activity was known to be an isotope of uranium. Chemistry performed by Abelson in May 1940 produced conclusive evidence that the 2.3 day activity was from the transuranic element 93 later named neptunium

  6. Promoting principals' managerial involvement in instructional improvement

    Science.gov (United States)

    Gillat, Alex; Sulzer-Azaroff, Beth

    1994-01-01

    Studies of school leadership suggest that visiting classrooms, emphasizing achievement and training, and supporting teachers are important indicators of the effectiveness of school principals. The utility of a behavior-analytic program to support the enhancement of these behaviors in 2 school principals and the impact of their involvement upon teachers' and students' performances in three classes were examined in two experiments, one at an elementary school and another at a secondary school. Treatment conditions consisted of helping the principal or teacher to schedule his or her time and to use goal setting, feedback, and praise. A withdrawal design (Experiment 1) and a multiple baseline across classrooms (Experiment 2) showed that the principal's and teacher's rates of praise, feedback, and goal setting increased during the intervention, and were associated with improvements in the academic performance of the students. In the future, school psychologists might analyze the impact of involving themselves in supporting the principal's involvement in improving students' and teachers' performances or in playing a similar leadership role themselves. PMID:16795819

  7. Dimensionality reduction of collective motion by principal manifolds

    Science.gov (United States)

    Gajamannage, Kelum; Butail, Sachit; Porfiri, Maurizio; Bollt, Erik M.

    2015-01-01

    While the existence of low-dimensional embedding manifolds has been shown in patterns of collective motion, the current battery of nonlinear dimensionality reduction methods is not amenable to the analysis of such manifolds. This is mainly due to the necessary spectral decomposition step, which limits control over the mapping from the original high-dimensional space to the embedding space. Here, we propose an alternative approach that demands a two-dimensional embedding which topologically summarizes the high-dimensional data. In this sense, our approach is closely related to the construction of one-dimensional principal curves that minimize orthogonal error to data points subject to smoothness constraints. Specifically, we construct a two-dimensional principal manifold directly in the high-dimensional space using cubic smoothing splines, and define the embedding coordinates in terms of geodesic distances. Thus, the mapping from the high-dimensional data to the manifold is defined in terms of local coordinates. Through representative examples, we show that compared to existing nonlinear dimensionality reduction methods, the principal manifold retains the original structure even in noisy and sparse datasets. The principal manifold finding algorithm is applied to configurations obtained from a dynamical system of multiple agents simulating a complex maneuver called predator mobbing, and the resulting two-dimensional embedding is compared with that of a well-established nonlinear dimensionality reduction method.

  8. Choreographies with Secure Boxes and Compromised Principals

    DEFF Research Database (Denmark)

    Carbone, Marco; Guttman, Joshua

    2009-01-01

      We equip choreography-level session descriptions with a simple abstraction of a security infrastruc- ture. Message components may be enclosed within (possibly nested) ”boxes” annotated with the intended source and destination of those components. The boxes are to be implemented with cryp......- tography. Strand spaces provide a semantics for these choreographies, in which some roles may be played by compromised principals. A skeleton is a partially ordered structure containing local behaviors (strands) executed by regular (non-compromised) principals. A skeleton is realized if it contains enough...... it embeds. Second, if no step is possible from a skeleton A, then A is DG realized. Finally, if a DG realized A′ is accessible from A, then A′ is minimal. Thus, the transition system provides a systematic way to construct the possible behaviors of the choreography, in the presence of compromised principals.  ...

  9. Principals, Trust, and Cultivating Vibrant Schools

    Directory of Open Access Journals (Sweden)

    Megan Tschannen-Moran

    2015-03-01

    Full Text Available Although principals are ultimately held accountable to student learning in their buildings, the most consistent research results have suggested that their impact on student achievement is largely indirect. Leithwood, Patten, and Jantzi proposed four paths through which this indirect influence would flow, and the purpose of this special issue is to examine in greater depth these mediating variables. Among mediating variables, we assert that trust is key. In this paper, we explore the evidence that points to the role that faculty trust in the principal plays in student learning and how principals can cultivate trust by attending to the five facets of trust, as well as the correlates of trust that mediate student learning, including academic press, collective teacher efficacy, and teacher professionalism. We argue that trust plays a role in each of the four paths identified by Leithwood, Patten, and Jantzi. Finally, we explore possible new directions for future research.

  10. Principal component regression for crop yield estimation

    CERN Document Server

    Suryanarayana, T M V

    2016-01-01

    This book highlights the estimation of crop yield in Central Gujarat, especially with regard to the development of Multiple Regression Models and Principal Component Regression (PCR) models using climatological parameters as independent variables and crop yield as a dependent variable. It subsequently compares the multiple linear regression (MLR) and PCR results, and discusses the significance of PCR for crop yield estimation. In this context, the book also covers Principal Component Analysis (PCA), a statistical procedure used to reduce a number of correlated variables into a smaller number of uncorrelated variables called principal components (PC). This book will be helpful to the students and researchers, starting their works on climate and agriculture, mainly focussing on estimation models. The flow of chapters takes the readers in a smooth path, in understanding climate and weather and impact of climate change, and gradually proceeds towards downscaling techniques and then finally towards development of ...

  11. Natural product discovery: past, present, and future.

    Science.gov (United States)

    Katz, Leonard; Baltz, Richard H

    2016-03-01

    Microorganisms have provided abundant sources of natural products which have been developed as commercial products for human medicine, animal health, and plant crop protection. In the early years of natural product discovery from microorganisms (The Golden Age), new antibiotics were found with relative ease from low-throughput fermentation and whole cell screening methods. Later, molecular genetic and medicinal chemistry approaches were applied to modify and improve the activities of important chemical scaffolds, and more sophisticated screening methods were directed at target disease states. In the 1990s, the pharmaceutical industry moved to high-throughput screening of synthetic chemical libraries against many potential therapeutic targets, including new targets identified from the human genome sequencing project, largely to the exclusion of natural products, and discovery rates dropped dramatically. Nonetheless, natural products continued to provide key scaffolds for drug development. In the current millennium, it was discovered from genome sequencing that microbes with large genomes have the capacity to produce about ten times as many secondary metabolites as was previously recognized. Indeed, the most gifted actinomycetes have the capacity to produce around 30-50 secondary metabolites. With the precipitous drop in cost for genome sequencing, it is now feasible to sequence thousands of actinomycete genomes to identify the "biosynthetic dark matter" as sources for the discovery of new and novel secondary metabolites. Advances in bioinformatics, mass spectrometry, proteomics, transcriptomics, metabolomics and gene expression are driving the new field of microbial genome mining for applications in natural product discovery and development.

  12. Research & market strategy: how choice of drug discovery approach can affect market position.

    Science.gov (United States)

    Sams-Dodd, Frank

    2007-04-01

    In principal, drug discovery approaches can be grouped into target- and function-based, with the respective aims of developing either a target-selective drug or a drug that produces a specific biological effect irrespective of its mode of action. Most analyses of drug discovery approaches focus on productivity, whereas the strategic implications of the choice of drug discovery approach on market position and ability to maintain market exclusivity are rarely considered. However, a comparison of approaches from the perspective of market position indicates that the functional approach is superior for the development of novel, innovative treatments.

  13. Evaluating the Effectiveness of Traditional and Alternative Principal Preparation Programs

    Science.gov (United States)

    Pannell, Summer; Peltier-Glaze, Bernnell M.; Haynes, Ingrid; Davis, Delilah; Skelton, Carrie

    2015-01-01

    This study sought to determine the effectiveness on increasing student achievement of principals trained in a traditional principal preparation program and those trained in an alternate route principal preparation program within the same Mississippi university. Sixty-six Mississippi principals and assistant principals participated in the study. Of…

  14. Riccati transformations and principal solutions of discrete linear systems

    International Nuclear Information System (INIS)

    Ahlbrandt, C.D.; Hooker, J.W.

    1984-01-01

    Consider a second-order linear matrix difference equation. A definition of principal and anti-principal, or recessive and dominant, solutions of the equation are given and the existence of principal and anti-principal solutions and the essential uniqueness of principal solutions is proven

  15. Discovery Mondays: Surveyors' Tools

    CERN Multimedia

    2003-01-01

    Surveyors of all ages, have your rulers and compasses at the ready! This sixth edition of Discovery Monday is your chance to learn about the surveyor's tools - the state of the art in measuring instruments - and see for yourself how they work. With their usual daunting precision, the members of CERN's Surveying Group have prepared some demonstrations and exercises for you to try. Find out the techniques for ensuring accelerator alignment and learn about high-tech metrology systems such as deviation indicators, tracking lasers and total stations. The surveyors will show you how they precisely measure magnet positioning, with accuracy of a few thousandths of a millimetre. You can try your hand at precision measurement using different types of sensor and a modern-day version of the Romans' bubble level, accurate to within a thousandth of a millimetre. You will learn that photogrammetry techniques can transform even a simple digital camera into a remarkable measuring instrument. Finally, you will have a chance t...

  16. Conseiller principal en communications (h/f) | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Résumé des fonctions Le conseiller principal en communications est chargé de la gestion des relations publiques de telecentre.org. Il est également responsable de l'élaboration et de la gestion des principales stratégies de communication et de mise en commun des connaissances, de même que des grandes stratégies ...

  17. Principal Component Analysis (Pca) Dan Aplikasinya Dengan Spss

    OpenAIRE

    Bus Umar, Hermita

    2009-01-01

    PCA (Principal Component Analysis ) are statistical techniques applied to a single set of variables when the researcher is interested in discovering which variables in the setform coherent subset that are relativity independent of one another.Variables that are correlated with one another but largely independent of other subset of variables are combined into factors. The Coals of PCA to which each variables is explained by each dimension. Step in PCA include selecting and mean measuring a set...

  18. Lysophospholipid receptors in drug discovery.

    Science.gov (United States)

    Kihara, Yasuyuki; Mizuno, Hirotaka; Chun, Jerold

    2015-05-01

    Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively. These LPs and their receptors have been implicated in both physiological and pathophysiological processes such as autoimmune diseases, neurodegenerative diseases, fibrosis, pain, cancer, inflammation, metabolic syndrome, bone formation, fertility, organismal development, and other effects on most organ systems. Advances in the LP receptor field have enabled the development of novel small molecules targeting LP receptors for several diseases. Most notably, fingolimod (FTY720, Gilenya, Novartis), an S1P receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis. This success is currently being followed by multiple, mechanistically related compounds targeting S1P receptor subtypes, which are in various stages of clinical development. In addition, an LPA1 antagonist, BMS-986020 (Bristol-Myers Squibb), is in Phase 2 clinical development for treating idiopathic pulmonary fibrosis, as a distinct compound, SAR100842 (Sanofi) for the treatment of systemic sclerosis and related fibrotic diseases. This review summarizes the current state of drug discovery in the LP receptor field. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection.

    Science.gov (United States)

    Shafiee, Mohammad Javad; Chung, Audrey G; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

    2017-10-01

    While lung cancer is the second most diagnosed form of cancer in men and women, a sufficiently early diagnosis can be pivotal in patient survival rates. Imaging-based, or radiomics-driven, detection methods have been developed to aid diagnosticians, but largely rely on hand-crafted features that may not fully encapsulate the differences between cancerous and healthy tissue. Recently, the concept of discovery radiomics was introduced, where custom abstract features are discovered from readily available imaging data. We propose an evolutionary deep radiomic sequencer discovery approach based on evolutionary deep intelligence. Motivated by patient privacy concerns and the idea of operational artificial intelligence, the evolutionary deep radiomic sequencer discovery approach organically evolves increasingly more efficient deep radiomic sequencers that produce significantly more compact yet similarly descriptive radiomic sequences over multiple generations. As a result, this framework improves operational efficiency and enables diagnosis to be run locally at the radiologist's computer while maintaining detection accuracy. We evaluated the evolved deep radiomic sequencer (EDRS) discovered via the proposed evolutionary deep radiomic sequencer discovery framework against state-of-the-art radiomics-driven and discovery radiomics methods using clinical lung CT data with pathologically proven diagnostic data from the LIDC-IDRI dataset. The EDRS shows improved sensitivity (93.42%), specificity (82.39%), and diagnostic accuracy (88.78%) relative to previous radiomics approaches.

  20. A Conceptual Framework for Understanding the Working Relationship between School Principals and Vice-Principals

    Science.gov (United States)

    Wong, Ping-Man

    2009-01-01

    Vice-principals' role and their relationship with principals are of paramount importance in shaping the effectiveness of school management, particularly after the implementation of school-based management (SBM) worldwide. This paper reports primarily on prior studies on the vice-principalship and suggests a framework to help explain the different…

  1. Statewide Data on Supply and Demand of Principals after Policy Changes to Principal Preparation in Illinois

    Science.gov (United States)

    Haller, Alicia; Hunt, Erika

    2016-01-01

    Research has demonstrated that principals have a powerful impact on school improvement and student learning. Principals play a vital role in recruiting, developing, and retaining effective teachers; creating a school-wide culture of learning; and implementing a continuous improvement plan aimed at increasing student achievement. Leithwood, Louis,…

  2. Principal Self-Efficacy, Teacher Perceptions of Principal Performance, and Teacher Job Satisfaction

    Science.gov (United States)

    Evans, Molly Lynn

    2016-01-01

    In public schools, the principal's role is of paramount importance in influencing teachers to excel and to keep their job satisfaction high. The self-efficacy of leaders is an important characteristic of leadership, but this issue has not been extensively explored in school principals. Using internet-based questionnaires, this study obtained…

  3. Emotional Expression at Different Managerial Career Stages: Female Principals in Arab Schools in Israel

    Science.gov (United States)

    Arar, Khalid

    2017-01-01

    This paper examines emotional expression experienced by female principals in the Arab school system in Israel over their managerial careers--role-related emotions that they choose to express or repress before others. I employed narrative methodology, interviewing nine female principals from the Arab school system to investigate expression of…

  4. A Study of How Secondary School Principals in Minnesota Perceive the Evaluation of Their Performance

    Science.gov (United States)

    Muenich, John Andrew

    2014-01-01

    The purpose for this study was to ascertain the perceptions principals of public secondary schools in Minnesota have in relation to the evaluation of their job performance. Responding principals reported that past evaluations have been fair and consistent but have questioned their value with regard to professional growth. When asked if student…

  5. A Systematic Review of the Relationships between Principal Characteristics and Student Achievement. REL 2016-091

    Science.gov (United States)

    Osborne-Lampkin, La'Tara; Folsom, Jessica Sidler; Herrington, Carolyn D.

    2015-01-01

    This systematic review of the relationships between principal characteristics and student achievement was created for educators, administrators, policy-makers, and other individuals interested in a comprehensive catalogue of research on relations between principal characteristics and student achievement. It synthesizes what is known about…

  6. Relationships among Principal Authentic Leadership and Teacher Trust and Engagement Levels

    Science.gov (United States)

    Bird, James J.; Wang, Chuang; Watson, Jim R.; Murray, Louise

    2009-01-01

    This study examined the relationships among the authentic leadership style of school principals and the trust and engagement levels of their teachers in a county school district in a Southeastern state. The authenticity of the school principal was found to be significantly positively related to teacher trust and teacher engagement levels. The…

  7. Teacher and Principal Perceptions of Authentic Leadership: Implications for Trust, Engagement, and Intention to Return

    Science.gov (United States)

    Bird, James J.; Wang, Chuang; Watson, Jim; Murray, Louise

    2012-01-01

    The focus of this study was to explore the relationships between the authentic leadership of building principals and the trust, engagement, and intention to return of their teaching staffs. School principals (n = 28) and their teaching staffs (n = 633) were surveyed. Teacher trust and engagement were found to be significantly related to principal…

  8. The Importance of Principals Supporting Dual Language Education: A Social Justice Leadership Framework

    Science.gov (United States)

    DeMatthews, David; Izquierdo, Elena

    2018-01-01

    Recent calls for social justice to be a key aspect of principal preparation have been made, but content related to the efficacy of dual language education has been a neglected area of educational leadership research, coursework, and principal preparation standards. We draw on scholarship focused on dual language education, social justice…

  9. The Role of the Principal's Leadership Style in the Implementation of ICT Policy

    Science.gov (United States)

    Hadjithoma-Garstka, Christina

    2011-01-01

    This paper presents findings of a study in information communication technology (ICT) implementation, on the principal's leadership style in relation to other factors that influence implementation. The principal's leadership style is perceived--on the basis of the characteristics of the context where the study was conducted--as a personal quality,…

  10. High School Principals Who Stay: Stability in a Time of Change

    Science.gov (United States)

    Luebke, Patricia A.

    2013-01-01

    This qualitative study explored the institutional factors, personal characteristics, and work-related relationships of high school principals that led to their longer than usual tenure in their positions. Data were gathered from interviews with ten high school principals who had served in their positions for a range of 8 to 23 years, much longer…

  11. School Principals, Leadership Coaches, and Student Achievement: Enhancing Self-Efficacy through the Coaching Relationship

    Science.gov (United States)

    Kelsen, Virginia E.

    2011-01-01

    School principals face an increasing number of professional demands, especially the challenge of improving student achievement. As such, the purpose of this dissertation is to study the effect of leadership coaching on a school principal's responsibilities related to carrying out these demands. Specifically, the researcher examined a subset of…

  12. School Principals' Evaluations of Their Instructional Leadership Behaviours: Realities vs. Ideals

    Science.gov (United States)

    Kalman, Mahmut; Arslan, Mustafa Cüneyt

    2016-01-01

    The purpose of the current study was to examine primary and middle school principals' evaluations of their own instructional leadership behaviours, and thereby pay closer attention to the ideal instructional leadership behaviours suggested in the related literature and the realities of principals' instructional leadership behaviours. Although…

  13. Workload Pressures of Principals: A Focus on Renewal, Support, and Mindfulness

    Science.gov (United States)

    Klocko, Barbara Ann; Wells, Caryn M.

    2015-01-01

    This study is designed to understand how principals perceive the common stressors associated with leading an educational enterprise and propose strategies for relief from job-related stressors. As such, the same survey results from principals in 2009 and 2012 are analyzed. The results indicated increases in the perceived state of stress with…

  14. Improving Principals' Instructional Leadership through Peer Coaching.

    Science.gov (United States)

    Roberts, Jo

    1991-01-01

    Describes an elementary peer leadership coaching project that enabled principals to improve their instructional leadership skills. Project evaluation indicated there was self-perceived growth in instructional leadership. Coaches underestimated the power of active listening. Specific peer matches did not affect the results. Flexibility,…

  15. relationship between principals' management approaches and ...

    African Journals Online (AJOL)

    Admin

    relationship between principals' management approaches and level of students' discipline in selected public secondary schools in Nyandarua and Laikipia districts, Kenya. Analysis of the relationship was based on school- size. Data were collected using a self-administered questionnaire from a sample of. 211 teachers, 28 ...

  16. How To Select a Good Assistant Principal.

    Science.gov (United States)

    Holman, Linda J.

    1997-01-01

    Notes that a well-structured job profile and interview can provide insight into the key qualities of an effective assistant principal. These include organizational skills, basic accounting knowledge, interpersonal skills, dependability, strong work ethic, effective problem-solving skills, leadership skills, written communication skills,…

  17. Summer Principals'/Directors' Orientation Training Module.

    Science.gov (United States)

    Mata, Robert L.; Garcia, Richard L.

    Intended to provide current or potential project principals/directors with the basic knowledge, skills, abilities, and sensitivities needed to manage a summer migrant school project in the local educational setting, this module provides instruction in the project management areas of planning, preparation, control, and termination. The module…

  18. Constructing principals' professional identities through life stories ...

    African Journals Online (AJOL)

    Adopting a humanistic perspective to the study of leadership, I discuss and describe how school principals adapt to their new roles, owing to the new education policies and educational restructuring within the South African. Department of Education. The Life History approach was used to collect data from six selected ...

  19. relationship between principals' management approaches and ...

    African Journals Online (AJOL)

    Admin

    management approach is more likely to increase teachers' and parental input on discipline ... satisfaction, which is a critical correlate of .... academic life. For this reason, this category of principals will rarely enlist the support of teachers and parents in their effort to enhance discipline. This may impact negatively on the ...

  20. Probabilistic Principal Component Analysis for Metabolomic Data.

    LENUS (Irish Health Repository)

    Nyamundanda, Gift

    2010-11-23

    Abstract Background Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, PCA is limited by the fact that it is not based on a statistical model. Results Here, probabilistic principal component analysis (PPCA) which addresses some of the limitations of PCA, is reviewed and extended. A novel extension of PPCA, called probabilistic principal component and covariates analysis (PPCCA), is introduced which provides a flexible approach to jointly model metabolomic data and additional covariate information. The use of a mixture of PPCA models for discovering the number of inherent groups in metabolomic data is demonstrated. The jackknife technique is employed to construct confidence intervals for estimated model parameters throughout. The optimal number of principal components is determined through the use of the Bayesian Information Criterion model selection tool, which is modified to address the high dimensionality of the data. Conclusions The methods presented are illustrated through an application to metabolomic data sets. Jointly modeling metabolomic data and covariates was successfully achieved and has the potential to provide deeper insight to the underlying data structure. Examination of confidence intervals for the model parameters, such as loadings, allows for principled and clear interpretation of the underlying data structure. A software package called MetabolAnalyze, freely available through the R statistical software, has been developed to facilitate implementation of the presented methods in the metabolomics field.

  1. Primary School Principals' Experiences with Smartphone Apps

    Science.gov (United States)

    Çakir, Rahman; Aktay, Sayim

    2016-01-01

    Smartphones are not just pieces of hardware, they at same time also dip into software features such as communication systems. The aim of this study is to examine primary school principals' experiences with smart phone applications. Shedding light on this subject means that this research is qualitative. Criterion sampling has been intentionally…

  2. Constructing principals' professional identities through life stories ...

    African Journals Online (AJOL)

    Adopting a humanistic perspective to the study of leadership, I discuss and describe how school principals adapt to their new roles, owing to the new education policies and educational restructuring within the South African Department of Education. The Life History approach was used to collect data from six selected school ...

  3. Women principals' reflections of curriculum management challenges ...

    African Journals Online (AJOL)

    ... to schools. The findings imply a need for greater capacity building amongst principals,as well as further research into continuous curriculum changes in the South African education system. Keywords: Annual National Assessments, management styles, rural primary schools, transformational leadership,women managers ...

  4. Experimental and principal component analysis of waste ...

    African Journals Online (AJOL)

    The present study is aimed at determining through principal component analysis the most important variables affecting bacterial degradation in ponds. Data were collected from literature. In addition, samples were also collected from the waste stabilization ponds at the University of Nigeria, Nsukka and analyzed to ...

  5. Principal Component Analysis as an Efficient Performance ...

    African Journals Online (AJOL)

    This paper uses the principal component analysis (PCA) to examine the possibility of using few explanatory variables (X's) to explain the variation in Y. It applied PCA to assess the performance of students in Abia State Polytechnic, Aba, Nigeria. This was done by estimating the coefficients of eight explanatory variables in a ...

  6. Secondary School Department Chair Roles: Principal Expectations

    Science.gov (United States)

    Brent, Brian O.; Deangelis, Karen J.; Surash, Barbara M.

    2014-01-01

    The literature on the principalship is extensive, revealing ways in which principals can foster or impede school success. At the same time, another formal secondary school-level position, the department chair, has garnered little scholarly attention. Thus far, the literature offers a limited account of the roles that chairs should or do perform in…

  7. Principal normal indicatrices of closed space curves

    DEFF Research Database (Denmark)

    Røgen, Peter

    1999-01-01

    A theorem due to J. Weiner, which is also proven by B. Solomon, implies that a principal normal indicatrix of a closed space curve with nonvanishing curvature has integrated geodesic curvature zero and contains no subarc with integrated geodesic curvature pi. We prove that the inverse problem alw...

  8. Dealing with Crises: One Principal's Experience.

    Science.gov (United States)

    Foley, Charles F.

    1986-01-01

    The principal of Concord High School (New Hampshire) recounts the 1985-86 school year's four crises--the visits of teacher-astronaut Christa McAuliffe and Secretary of Education William Bennett, the shooting of a former student, and the Challenger space shuttle explosion. The greatest challenge was resuming the normal schedule and fielding media…

  9. Spatial control of groundwater contamination, using principal ...

    Indian Academy of Sciences (India)

    A study on the geochemistry of groundwater was carried out in a river basin of Andhra Pradesh to probe into the spatial controlling processes of groundwater contamination, using principal component analysis (PCA). The PCA transforms the chemical variables, pH, EC, Ca2+, Mg2+, Na+, K+, HCO 3 − , Cl−, SO 4 2 − , NO 3 ...

  10. Principal Connection / Amazon and the Whole Teacher

    Science.gov (United States)

    Hoerr, Thomas R.

    2015-01-01

    A recent controversy over Amazon's culture has strong implications for the whole child approach, and it offers powerful lessons for principals. A significant difference between the culture of so many businesses today and the culture at good schools is that in good schools, the welfare of the employees is very important. Student success is the…

  11. Thinking Styles of Teachers, Principals, and Inspectors

    Science.gov (United States)

    Bastug, Özlem Yesim Özbek; Çelik, Bünyamin

    2014-01-01

    Much of current studies focus on the investigation of the thinking styles of students and teachers. However, exploring school administrators' and inpectors' thinking styles is also critical for increasing students' achievement at school. For that purpose, this study was performed to determine the thinking styles of teachers, principals, and…

  12. The Gender of Secondary School Principals.

    Science.gov (United States)

    Bonuso, Carl; Shakeshaft, Charol

    1983-01-01

    A study was conducted to understand why so few of the secondary school principals in New York State are women. Results suggest two possible causes: either sufficient women candidates do not apply for the positions, or sex discrimination still exists. (KH)

  13. Building Blocks for the New Principal

    Science.gov (United States)

    Beckerman, Leon

    2005-01-01

    After all of the theories, strategies, discussions, and classes are completed, new principals often still feel isolated and think they have to reinvent the wheel to learn the basic lessons of leadership--how to improve school climate, how to provide leadership for change, how to communicate effectively, and how to manage time. However, they do not…

  14. A Principal's Guide to Children's Allergies.

    Science.gov (United States)

    Munoz-Furlong, Anne

    1999-01-01

    Discusses several common children's allergies, including allergic rhinitis, asthma, atopic dermatitis, food allergies, and anaphylactic shock. Principals should become familiar with various medications and should work with children's parents and physicians to determine how to manage their allergies at school. Allergen avoidance is the best…

  15. Principal component analysis of psoriasis lesions images

    DEFF Research Database (Denmark)

    Maletti, Gabriela Mariel; Ersbøll, Bjarne Kjær

    2003-01-01

    A set of RGB images of psoriasis lesions is used. By visual examination of these images, there seem to be no common pattern that could be used to find and align the lesions within and between sessions. It is expected that the principal components of the original images could be useful during future...

  16. Great Schools Have Great Principals: Link Crew

    Science.gov (United States)

    Roberts, Rebecca

    2013-01-01

    The author describes the Link Crew transition program that she implemented in 2012 as assistant principal for curriculum and guidance at Villa Park High School in California. She states that administrative and counseling teams at her school had noticed that ninth-grade students struggled in their transitions to high school, with over half of the…

  17. Principals' Transformational Leadership in School Improvement

    Science.gov (United States)

    Yang, Yingxiu

    2013-01-01

    Purpose: This paper aims to contribute experience and ideas of the transformational leadership, not only for the principal want to improve leadership himself (herself), but also for the school at critical period of improvement, through summarizing forming process and the problem during the course and key factors that affect the course.…

  18. Relationship Between Secondary School Principals' Leadership ...

    African Journals Online (AJOL)

    Significant relationship also existed between autocratic leadership style and teachers' job performance (r =-314,N = 300, P<.01). Considering the findings of this study, it was recommended that school principals should imbibe a mixture of autocratic and democratic styles of leadership in their school administration in order to ...

  19. Principal normal indicatrices of closed space curves

    DEFF Research Database (Denmark)

    Røgen, Peter

    1997-01-01

    A theorem due to J. Weiner, which also is proven by B. Solomon, implies that a principal normal indicatrix of a closed space curve with non-vanishing curvature has integrated geodesic curvature zero and contains no sub arc with integrated geodesic curvature Pi. We prove that the inverse problem...

  20. The Relationship between Principals' Managerial Approaches and ...

    African Journals Online (AJOL)

    Students' discipline is critical to the attainment of positive school outcomes. This paper presents and discusses findings of a study on the relationship between principals' management approaches and the level of student discipline in selected public secondary schools in Kenya. The premise of the study was that the level of ...

  1. Principal component analysis implementation in Java

    Science.gov (United States)

    Wójtowicz, Sebastian; Belka, Radosław; Sławiński, Tomasz; Parian, Mahnaz

    2015-09-01

    In this paper we show how PCA (Principal Component Analysis) method can be implemented using Java programming language. We consider using PCA algorithm especially in analysed data obtained from Raman spectroscopy measurements, but other applications of developed software should also be possible. Our goal is to create a general purpose PCA application, ready to run on every platform which is supported by Java.

  2. Principals' Leadership Styles and Student Achievement

    Science.gov (United States)

    Harnish, David Alan

    2012-01-01

    Many schools struggle to meet No Child Left Behind's stringent adequate yearly progress standards, although the benchmark has stimulated national creativity and reform. The purpose of this study was to explore teacher perceptions of principals' leadership styles, curriculum reform, and student achievement to ascertain possible factors to improve…

  3. Islamitisch financieren tussen principes en realiteit

    NARCIS (Netherlands)

    Wolters, W.G.

    2009-01-01

    ‘De financiële crisis zou niet hebben plaatsgevonden, als de wereld de principes van islamitisch bankieren en financieren zou hebben aangenomen.’ Dat was één van de kenmerkende reacties van de kant van de islamitische bankiers, in de laatste maanden van 2008. Toen begon de wereldwijde financiële

  4. What Principals Should Know About Food Allergies.

    Science.gov (United States)

    Munoz-Furlong, Anne

    2002-01-01

    Describes what principals should know about recent research findings on food allergies (peanuts, tree nuts, milk, eggs, soy, wheat) that can produce severe or life-threatening reactions in children. Asserts that every school should have trained staff and written procedures for reacting quickly to allergic reactions. (PKP)

  5. Swedish Chemists and Discovery of the Elements

    Science.gov (United States)

    Thomsen, Volker

    1996-10-01

    All of the elements not already known from antiquity were discovered in Europe and North America. So which country ranks number one on the discovery list? The question occurred to me while leafing through reference 1 in search of thermodynamic data on silicon. Never having seen such a tabulation, I wondered if it might prove useful in teaching. The question has a sports-related flavor that will appeal to many students. Personally, I picked England or Germany for #1. The actual result is surprising. The ranking considering only up to atomic number 103 is as follows: Note: Where two or more independent discoveries have been made, each country is credited. In the "others" category Austria and Denmark each has two discoveries. The remaining countries, with one each, are Finland, Italy, Mexico, Poland, Romania, Russia, and Spain. The high place for the USA is primarily due to the work done at Berkeley and Los Alamos on the transuranics. Without these discoveries, the US would have tied with Switzerland at three elements. Perhaps the most interesting aspect of this tabulation is that Swedish chemists have discovered the most elements. Four chemists alone account for twelve of the 20 discoveries: Baron Jöns Jakob Berzelius (1779-1848) is credited with four elements. His pupil, friend, and assistant, Carl Gustav Mosander (1797-1858) discovered three. P. T. Cleve also found three elements and Karl Wilhelm Scheele (1742-1786) discovered two. Biographical research on the Swedish chemists is a suitable assignment at the introductory level. Reasons for the predominance of Swedish chemists presents a challenging student research topic in the history of chemistry. Another interesting question at the introductory level is, transuranics aside, who discovered the most elements? At the more advanced level the question becomes, why? Literature Cited: 1. Emsley, J. The Elements; Clarendon: Oxford, 1989.

  6. Inseparability of science history and discovery

    Directory of Open Access Journals (Sweden)

    J. M. Herndon

    2010-04-01

    Full Text Available Science is very much a logical progression through time. Progressing along a logical path of discovery is rather like following a path through the wilderness. Occasionally the path splits, presenting a choice; the correct logical interpretation leads to further progress, the wrong choice leads to confusion. By considering deeply the relevant science history, one might begin to recognize past faltering in the logical progression of observations and ideas and, perhaps then, to discover new, more precise understanding. The following specific examples of science faltering are described from a historical perspective: (1 Composition of the Earth's inner core; (2 Giant planet internal energy production; (3 Physical impossibility of Earth-core convection and Earth-mantle convection, and; (4 Thermonuclear ignition of stars. For each example, a revised logical progression is described, leading, respectively, to: (1 Understanding the endo-Earth's composition; (2 The concept of nuclear georeactor origin of geo- and planetary magnetic fields; (3 The invalidation and replacement of plate tectonics; and, (4 Understanding the basis for the observed distribution of luminous stars in galaxies. These revised logical progressions clearly show the inseparability of science history and discovery. A different and more fundamental approach to making scientific discoveries than the frequently discussed variants of the scientific method is this: An individual ponders and through tedious efforts arranges seemingly unrelated observations into a logical sequence in the mind so that causal relationships become evident and new understanding emerges, showing the path for new observations, for new experiments, for new theoretical considerations, and for new discoveries. Science history is rich in "seemingly unrelated observations" just waiting to be logically and causally related to reveal new discoveries.

  7. Stochastic convex sparse principal component analysis.

    Science.gov (United States)

    Baytas, Inci M; Lin, Kaixiang; Wang, Fei; Jain, Anil K; Zhou, Jiayu

    2016-12-01

    Principal component analysis (PCA) is a dimensionality reduction and data analysis tool commonly used in many areas. The main idea of PCA is to represent high-dimensional data with a few representative components that capture most of the variance present in the data. However, there is an obvious disadvantage of traditional PCA when it is applied to analyze data where interpretability is important. In applications, where the features have some physical meanings, we lose the ability to interpret the principal components extracted by conventional PCA because each principal component is a linear combination of all the original features. For this reason, sparse PCA has been proposed to improve the interpretability of traditional PCA by introducing sparsity to the loading vectors of principal components. The sparse PCA can be formulated as an ℓ 1 regularized optimization problem, which can be solved by proximal gradient methods. However, these methods do not scale well because computation of the exact gradient is generally required at each iteration. Stochastic gradient framework addresses this challenge by computing an expected gradient at each iteration. Nevertheless, stochastic approaches typically have low convergence rates due to the high variance. In this paper, we propose a convex sparse principal component analysis (Cvx-SPCA), which leverages a proximal variance reduced stochastic scheme to achieve a geometric convergence rate. We further show that the convergence analysis can be significantly simplified by using a weak condition which allows a broader class of objectives to be applied. The efficiency and effectiveness of the proposed method are demonstrated on a large-scale electronic medical record cohort.

  8. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi

    2014-01-01

    to the antibody science in every project in antibody drug discovery. Recent experimental technologies allow for the rapid generation of large-scale data on antibody sequences, affinity, potency, structures, and biological functions; this should accelerate drug discovery research. Therefore, a robust bioinformatic...... infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...

  9. Discovery of the cadmium isotopes

    International Nuclear Information System (INIS)

    Amos, S.; Thoennessen, M.

    2010-01-01

    Thirty-seven cadmium isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  10. Synthetic biology of antimicrobial discovery

    Science.gov (United States)

    Zakeri, Bijan; Lu, Timothy K.

    2012-01-01

    Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore, used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. PMID:23654251

  11. Scientific discovery through weighted sampling

    NARCIS (Netherlands)

    E. Sidirourgos (Eleftherios); M.L. Kersten (Martin); P.A. Boncz (Peter)

    2013-01-01

    textabstractScientific discovery has shifted from being an exercise of theory and computation, to become the exploration of an ocean of observational data. Scientists explore data originated from modern scientific instruments in order to discover

  12. Exosomes in urine biomarker discovery.

    Science.gov (United States)

    Huebner, Alyssa R; Somparn, Poorichaya; Benjachat, Thitima; Leelahavanichkul, Asada; Avihingsanon, Yingyos; Fenton, Robert A; Pisitkun, Trairak

    2015-01-01

    Nanovesicles present in urine the so-called urinary exosomes have been found to be secreted by every epithelial cell type lining the urinary tract system in human. Urinary exosomes are an appealing source for biomarker discovery as they contain molecular constituents of their cell of origin, including proteins and genetic materials, and they can be isolated in a non-invasive manner. Following the discovery of urinary exosomes in 2004, many studies have been performed using urinary exosomes as a starting material to identify biomarkers in various renal, urogenital, and systemic diseases. Here, we describe the discovery of urinary exosomes and address the issues on the collection, isolation, and normalization of urinary exosomes as well as delineate the systems biology approach to biomarker discovery using urinary exosomes.

  13. Principal parameters of classical multiply charged ion sources

    International Nuclear Information System (INIS)

    Winter, H.; Wolf, B.H.

    1974-01-01

    A review is given of the operational principles of classical multiply charged ion sources (operating sources for intense beams of multiply charged ions using discharge plasmas; MCIS). The fractional rates of creation of multiply charged ions in MCIS plasmas cannot be deduced from the discharge parameters in a simple manner; they depend essentially on three principal parameters, the density and energy distribution of the ionizing electrons, and the confinement time of ions in the ionization space. Simple discharge models were used to find relations between principal parameters, and results of model calculations are compared to actually measured charge state density distributions of extracted ions. Details of processes which determine the energy distribution of ionizing electrons (heating effects), confinement times of ions (instabilities), and some technical aspects of classical MCIS (cathodes, surface processes, conditioning, life time) are discussed

  14. Respiratory knowledge discovery utilising expertise

    Directory of Open Access Journals (Sweden)

    Tristan Ling

    2012-12-01

    Full Text Available BackgroundSignificant amounts of medical data are being archived, in the hope that they can be analysed and provide insight. A critical problem with analysing such data is the amount of existing knowledge required to produce effective results.AimsThis study tests a method that seeks to overcome these problems with analysis, by testing it over a large set of archived lung function test results. A knowledge base of lung function interpretation expertise has been compiled and serves as a base for analysis.MethodA user examines the dataset with the assistance of the knowledge discovery tool. Two pertinent respiratory research questions are analysed (the relative correlation between diffusing capacity and FEV1 or FVC bronchodilator response, and the effects of BMI on various parameters of lung function, and the results compared and contrasted with relevant literature.ResultsThe method finds interesting results from the lung function data supporting and questioning other published studies, while also finding correlations that suggest further areas of research.ConclusionWhile the analysis does not necessarily reveal groundbreaking information, it shows that the method can successfully discover new knowledge and is useful in a research context.

  15. West Nile Virus Drug Discovery

    Directory of Open Access Journals (Sweden)

    Siew Pheng Lim

    2013-12-01

    Full Text Available The outbreak of West Nile virus (WNV in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery. A number of approaches have been used to search for inhibitors of WNV, including viral infection-based screening, enzyme-based screening, structure-based virtual screening, structure-based rationale design, and antibody-based therapy. These efforts have yielded inhibitors of viral or cellular factors that are critical for viral replication. For small molecule inhibitors, no promising preclinical candidate has been developed; most of the inhibitors could not even be advanced to the stage of hit-to-lead optimization due to their poor drug-like properties. However, several inhibitors developed for related members of the family Flaviviridae, such as dengue virus and hepatitis C virus, exhibited cross-inhibition of WNV, suggesting the possibility to re-purpose these antivirals for WNV treatment. Most promisingly, therapeutic antibodies have shown excellent efficacy in mouse model; one of such antibodies has been advanced into clinical trial. The knowledge accumulated during the past fifteen years has provided better rationale for the ongoing WNV and other flavivirus antiviral development.

  16. Radioactivity. Centenary of radioactivity discovery

    International Nuclear Information System (INIS)

    Charpak, G.; Tubiana, M.; Bimbot, R.

    1997-01-01

    This small booklet was edited for the occasion of the exhibitions of the celebration of the centenary of radioactivity discovery which took place in various locations in France from 1996 to 1998. It recalls some basic knowledge concerning radioactivity and its applications: history of discovery, atoms and isotopes, radiations, measurement of ionizing radiations, natural and artificial radioactivity, isotope dating and labelling, radiotherapy, nuclear power and reactors, fission and fusion, nuclear wastes, dosimetry, effects and radioprotection. (J.S.)

  17. Computational methods in drug discovery

    Directory of Open Access Journals (Sweden)

    Sumudu P. Leelananda

    2016-12-01

    Full Text Available The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery projects. Additionally, increasing knowledge of biological structures, as well as increasing computer power have made it possible to use computational methods effectively in various phases of the drug discovery and development pipeline. The importance of in silico tools is greater than ever before and has advanced pharmaceutical research. Here we present an overview of computational methods used in different facets of drug discovery and highlight some of the recent successes. In this review, both structure-based and ligand-based drug discovery methods are discussed. Advances in virtual high-throughput screening, protein structure prediction methods, protein–ligand docking, pharmacophore modeling and QSAR techniques are reviewed.

  18. Pathways to new drug discovery in neuropsychiatry.

    Science.gov (United States)

    Berk, Michael

    2012-11-29

    There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and colleagues that treatment with sulfonylurea and metformin reduces the risk of affective disorder. However, the identification of agents targeting disorder-related biomarkers is currently proving particularly fruitful. There is considerable hope for genetics as a purist, pathophysiologically valid pathway to drug discovery; however, it is unclear whether the science is ready to meet this promise. Fruitful paradigms will require a break from the orthodoxy, and creativity and risk may well be the fingerprints of success.See related article http://www.biomedcentral.com/1741-7015/10/150.

  19. Pathways to new drug discovery in neuropsychiatry

    Directory of Open Access Journals (Sweden)

    Berk Michael

    2012-11-01

    Full Text Available Abstract There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and colleagues that treatment with sulfonylurea and metformin reduces the risk of affective disorder. However, the identification of agents targeting disorder-related biomarkers is currently proving particularly fruitful. There is considerable hope for genetics as a purist, pathophysiologically valid pathway to drug discovery; however, it is unclear whether the science is ready to meet this promise. Fruitful paradigms will require a break from the orthodoxy, and creativity and risk may well be the fingerprints of success. See related article http://www.biomedcentral.com/1741-7015/10/150

  20. Discovery and Selection of Semantic Web Services

    CERN Document Server

    Wang, Xia

    2013-01-01

    For advanced web search engines to be able not only to search for semantically related information dispersed over different web pages, but also for semantic services providing certain functionalities, discovering semantic services is the key issue. Addressing four problems of current solution, this book presents the following contributions. A novel service model independent of semantic service description models is proposed, which clearly defines all elements necessary for service discovery and selection. It takes service selection as its gist and improves efficiency. Corresponding selection algorithms and their implementation as components of the extended Semantically Enabled Service-oriented Architecture in the Web Service Modeling Environment are detailed. Many applications of semantic web services, e.g. discovery, composition and mediation, can benefit from a general approach for building application ontologies. With application ontologies thus built, services are discovered in the same way as with single...

  1. PCA: Principal Component Analysis for spectra modeling

    Science.gov (United States)

    Hurley, Peter D.; Oliver, Seb; Farrah, Duncan; Wang, Lingyu; Efstathiou, Andreas

    2012-07-01

    The mid-infrared spectra of ultraluminous infrared galaxies (ULIRGs) contain a variety of spectral features that can be used as diagnostics to characterize the spectra. However, such diagnostics are biased by our prior prejudices on the origin of the features. Moreover, by using only part of the spectrum they do not utilize the full information content of the spectra. Blind statistical techniques such as principal component analysis (PCA) consider the whole spectrum, find correlated features and separate them out into distinct components. This code, written in IDL, classifies principal components of IRS spectra to define a new classification scheme using 5D Gaussian mixtures modelling. The five PCs and average spectra for the four classifications to classify objects are made available with the code.

  2. A Genealogical Interpretation of Principal Components Analysis

    Science.gov (United States)

    McVean, Gil

    2009-01-01

    Principal components analysis, PCA, is a statistical method commonly used in population genetics to identify structure in the distribution of genetic variation across geographical location and ethnic background. However, while the method is often used to inform about historical demographic processes, little is known about the relationship between fundamental demographic parameters and the projection of samples onto the primary axes. Here I show that for SNP data the projection of samples onto the principal components can be obtained directly from considering the average coalescent times between pairs of haploid genomes. The result provides a framework for interpreting PCA projections in terms of underlying processes, including migration, geographical isolation, and admixture. I also demonstrate a link between PCA and Wright's fst and show that SNP ascertainment has a largely simple and predictable effect on the projection of samples. Using examples from human genetics, I discuss the application of these results to empirical data and the implications for inference. PMID:19834557

  3. Principal component analysis applied to remote sensing

    Directory of Open Access Journals (Sweden)

    Javier Estornell

    2013-06-01

    Full Text Available The main objective of this article was to show an application of principal component analysis (PCA which is used in two science degrees. Particularly, PCA analysis was used to obtain information of the land cover from satellite images. Three Landsat images were selected from two areas which were located in the municipalities of Gandia and Vallat, both in the Valencia province (Spain. In the first study area, just one Landsat image of the 2005 year was used. In the second study area, two Landsat images were used taken in the 1994 and 2000 years to analyse the most significant changes in the land cover. According to the results, the second principal component of the Gandia area image allowed detecting the presence of vegetation. The same component in the Vallat area allowed detecting a forestry area affected by a forest fire. Consequently in this study we confirmed the feasibility of using PCA in remote sensing to extract land use information.

  4. Principal bundles on the projective line

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    LetX be a complete nonsingular curve over the algebraic closurek ofk andGa reductive group over k. Let E → X be a principal G-bundle on X. E is said to be semistable if, for every reduction of structure group EP ⊂ E to a maximal parabolic subgroup P of G, we have degree EP (p) ≤ 0, where p is the Lie algebra of P and EP ...

  5. Principal bundles on the projective line

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    E-mail: vikram@math.tifr.res.in; subramnn@math.tifr.res.in. MS received 21 January 2002; revised 19 April 2002. Abstract. We classify principal G-bundles on the projective line over an arbitrary field k of characteristic = 2 or 3, where G is a reductive group. If such a bundle is trivial at a k-rational point, then the structure group ...

  6. Principal Component Analysis of Anhui Agricultural Industrialization

    OpenAIRE

    Chen, Li

    2011-01-01

    Part 1: Simulation, Optimization, Monitoring and Control Technology; International audience; This paper is discussed the Anhui agricultural industrialization using the method of principal component analysis. The indexes include per capita net income of farmers in Anhui province, non-agricultural employment rate, urbanization rate, the total power of agricultural mechanization, universal ratio of rural water, car villages, the proportion of industrial waste water by sewage treatment in total e...

  7. A brief history of the discovery of tick-borne encephalitis virus in the late 1930s (based on reminiscences of members of the expeditions, their colleagues, and relatives).

    Science.gov (United States)

    Zlobin, Vladimir I; Pogodina, Vanda V; Kahl, Olaf

    2017-10-01

    Tick-borne encephalitis virus is the etiological agent of a severe human disease transmitted by hard ticks. It occurs in large parts of eastern, central, and western Asia and in Europe with thousands of human cases each year. Here, the discovery of the virus by Soviet scientists in the late 1930s in the Far East is described. The pioneering work involved with this discovery, which resulted in great scientific and epidemiological achievement, was undertaken under the most difficult conditions, and some of the scientists and their technical assistants paid for it with their health and even their lives. This paper briefly outlines the steps on the way that elucidated the basic etiology and eco-epidemiology of the disease, and does not omit that, as one result of the expeditions and the political situation in the former Soviet Union at that time, some scientists were sent to prison. Copyright © 2017 Elsevier GmbH. All rights reserved.

  8. Multilevel sparse functional principal component analysis.

    Science.gov (United States)

    Di, Chongzhi; Crainiceanu, Ciprian M; Jank, Wolfgang S

    2014-01-29

    We consider analysis of sparsely sampled multilevel functional data, where the basic observational unit is a function and data have a natural hierarchy of basic units. An example is when functions are recorded at multiple visits for each subject. Multilevel functional principal component analysis (MFPCA; Di et al. 2009) was proposed for such data when functions are densely recorded. Here we consider the case when functions are sparsely sampled and may contain only a few observations per function. We exploit the multilevel structure of covariance operators and achieve data reduction by principal component decompositions at both between and within subject levels. We address inherent methodological differences in the sparse sampling context to: 1) estimate the covariance operators; 2) estimate the functional principal component scores; 3) predict the underlying curves. Through simulations the proposed method is able to discover dominating modes of variations and reconstruct underlying curves well even in sparse settings. Our approach is illustrated by two applications, the Sleep Heart Health Study and eBay auctions.

  9. A principal components model of soundscape perception.

    Science.gov (United States)

    Axelsson, Östen; Nilsson, Mats E; Berglund, Birgitta

    2010-11-01

    There is a need for a model that identifies underlying dimensions of soundscape perception, and which may guide measurement and improvement of soundscape quality. With the purpose to develop such a model, a listening experiment was conducted. One hundred listeners measured 50 excerpts of binaural recordings of urban outdoor soundscapes on 116 attribute scales. The average attribute scale values were subjected to principal components analysis, resulting in three components: Pleasantness, eventfulness, and familiarity, explaining 50, 18 and 6% of the total variance, respectively. The principal-component scores were correlated with physical soundscape properties, including categories of dominant sounds and acoustic variables. Soundscape excerpts dominated by technological sounds were found to be unpleasant, whereas soundscape excerpts dominated by natural sounds were pleasant, and soundscape excerpts dominated by human sounds were eventful. These relationships remained after controlling for the overall soundscape loudness (Zwicker's N(10)), which shows that 'informational' properties are substantial contributors to the perception of soundscape. The proposed principal components model provides a framework for future soundscape research and practice. In particular, it suggests which basic dimensions are necessary to measure, how to measure them by a defined set of attribute scales, and how to promote high-quality soundscapes.

  10. Link layer topology discovery in an uncooperative ethernet environment

    CSIR Research Space (South Africa)

    Delport, JP

    2007-05-01

    Full Text Available on a Shared Medium. . . . . . . . 16 3.1 Early Hand-Drawn Map of the Internet. . . . . . . . . . . . . 19 4.1 Pseudo-Code for Parsing ARP Packets. . . . . . . . . . . . . . 35 4.2 Example ARP Packet in PDML Syntax. . . . . . . . . . . . . 36 4.3 Example... the network. In particular, physical or link layer topology discovery concerns itself with finding the physical connections between network elements. Topology discovery is also related to the act of mapping, as was performed by the cartographers of old...

  11. Applying Hierarchical Task Analysis Method to Discovery Layer Evaluation

    Directory of Open Access Journals (Sweden)

    Marlen Promann

    2015-03-01

    Full Text Available Libraries are implementing discovery layers to offer better user experiences. While usability tests have been helpful in evaluating the success or failure of implementing discovery layers in the library context, the focus has remained on its relative interface benefits over the traditional federated search. The informal site- and context specific usability tests have offered little to test the rigor of the discovery layers against the user goals, motivations and workflow they have been designed to support. This study proposes hierarchical task analysis (HTA as an important complementary evaluation method to usability testing of discovery layers. Relevant literature is reviewed for the discovery layers and the HTA method. As no previous application of HTA to the evaluation of discovery layers was found, this paper presents the application of HTA as an expert based and workflow centered (e.g. retrieving a relevant book or a journal article method to evaluating discovery layers. Purdue University’s Primo by Ex Libris was used to map eleven use cases as HTA charts. Nielsen’s Goal Composition theory was used as an analytical framework to evaluate the goal carts from two perspectives: a users’ physical interactions (i.e. clicks, and b user’s cognitive steps (i.e. decision points for what to do next. A brief comparison of HTA and usability test findings is offered as a way of conclusion.

  12. Universal Knowledge Discovery from Big Data: Towards a Paradigm Shift from 'Knowledge Discovery' to 'Wisdom Discovery'

    OpenAIRE

    Shen, Bin

    2014-01-01

    Many people hold a vision that big data will provide big insights and have a big impact in the future, and big-data-assisted scientific discovery is seen as an emerging and promising scientific paradigm. However, how to turn big data into deep insights with tremendous value still remains obscure. To meet the challenge, universal knowledge discovery from big data (UKD) is proposed. The new concept focuses on discovering universal knowledge, which exists in the statistical analyses of big data ...

  13. Principal Investigator-in-a-Box

    Science.gov (United States)

    Young, Laurence R.

    1999-01-01

    Human performance in orbit is currently limited by several factors beyond the intrinsic awkwardness of motor control in weightlessness. Cognitive functioning can be affected by such factors as cumulative sleep loss, stress and the psychological effects of long-duration small-group isolation. When an astronaut operates a scientific experiment, the performance decrement associated with such factors can lead to lost or poor quality data and even the total loss of a scientific objective, at great cost to the sponsors and to the dismay of the Principal Investigator. In long-duration flights, as anticipated on the International Space Station and on any planetary exploration, the experimental model is further complicated by long delays between training and experiment, and the large number of experiments each crew member must perform. Although no documented studies have been published on the subject, astronauts report that an unusually large number of simple errors are made in space. Whether a result of the effects of microgravity, accumulated fatigue, stress or other factors, this pattern of increased error supports the need for a computerized decision-making aid for astronauts performing experiments. Artificial intelligence and expert systems might serve as powerful tools for assisting experiments in space. Those conducting space experiments typically need assistance exactly when the planned checklist does not apply. Expert systems, which use bits of human knowledge and human methods to respond appropriately to unusual situations, have a flexibility that is highly desirable in circumstances where an invariably predictable course of action/response does not exist. Frequently the human expert on the ground is unavailable, lacking the latest information, or not consulted by the astronaut conducting the experiment. In response to these issues, we have developed "Principal Investigator-in-a-Box," or [PI], to capture the reasoning process of the real expert, the Principal

  14. Advances in knowledge discovery in databases

    CERN Document Server

    Adhikari, Animesh

    2015-01-01

    This book presents recent advances in Knowledge discovery in databases (KDD) with a focus on the areas of market basket database, time-stamped databases and multiple related databases. Various interesting and intelligent algorithms are reported on data mining tasks. A large number of association measures are presented, which play significant roles in decision support applications. This book presents, discusses and contrasts new developments in mining time-stamped data, time-based data analyses, the identification of temporal patterns, the mining of multiple related databases, as well as local patterns analysis.  

  15. Shuttle Discovery Landing at Edwards

    Science.gov (United States)

    1989-01-01

    The STS-29 Space Shuttle Discovery mission lands at NASA's then Ames-Dryden Flight Research Facility, Edwards AFB, California, early Saturday morning, 18 March 1989. Touchdown was at 6:35:49 a.m. PST and wheel stop was at 6:36:40 a.m. on runway 22. Controllers chose the concrete runway for the landing in order to make tests of braking and nosewheel steering. The STS-29 mission was very successful, completing the launch of a Tracking and Data Relay communications satellite, as well as a range of scientific experiments. Discovery's five-man crew was led by Commander Michael L. Coats, and included pilot John E. Blaha and mission specialists James P. Bagian, Robert C. Springer, and James F. Buchli. Space Shuttles are the main element of America's Space Transportation System and are used for space research and other space applications. The shuttles are the first vehicles capable of being launched into space and returning to Earth on a routine basis. Space Shuttles are used as orbiting laboratories in which scientists and mission specialists conduct a wide variety of scientific experiments. Crews aboard shuttles place satellites in orbit, rendezvous with satellites to carry out repair missions and return them to space, and retrieve satellites and return them to Earth for refurbishment and reuse. Space Shuttles are true aerospace vehicles. They leave Earth and its atmosphere under rocket power provided by three liquid-propellant main engines with two solid-propellant boosters attached plus an external liquid-fuel tank. After their orbital missions, they streak back through the atmosphere and land like airplanes. The returning shuttles, however, land like gliders, without power and on runways. Other rockets can place heavy payloads into orbit, but, they can only be used once. Space Shuttles are designed to be continually reused. When Space Shuttles are used to transport complete scientific laboratories into space, the laboratories remain inside the payload bay throughout

  16. Principal Hugonuot and decaying shock Hugoniot on silicates

    Science.gov (United States)

    Sekine, Toshimori; Ozaki, Norimasa; Kodama, Ryosuke; Uneda, Yuhei; Sato, Tomoko; Miyanishi, Kohei; Nishikawa, Toyohito; Toshimori Sekine Collaboration; Norimasa Ozaki Collaboration

    2017-06-01

    Laser shock experiments can achieve warm dense matter conditions applicable to the formation of planets and interior of large planets. The techniques of velocity interferometer system for ant reflector (VISAR) and streaked optical pyrometer (SOP) are used to observe the laser-shocked materials above 200 GPa, where the shock fronts in most materials become effective reflectors. The VISAR and SOP profiles give shock velocity and temperature directly if the shock structure is one-wave. In the measurement of principal Hugoniot we need one more parameter such as particle velocity that will be determined in a simultaneous measurement of a reference by the impedance match method. In decaying shock measurements, shock velocity and temperature of a sample are monitored simultaneously and pressure will be read using the principal Hugonot relation available as known experimentally or predicted. If two-wave structures appear at phase transition, the analyses are complicated. Therefore we must be careful in applying the decaying shock data to planetary problems. I summarize them by comparing the difference between the principal and decaying Hugoniots of silicates.

  17. The Interdependence of Principal School Leadership and Student Achievement

    Science.gov (United States)

    Soehner, David; Ryan, Thomas

    2011-01-01

    This review illuminated principal school leadership as a variable that impacted achievement. The principal as school leader and manager was explored because these roles were thought to impact student achievement both directly and indirectly. Specific principal leadership behaviors and principal effectiveness were explored as variables potentially…

  18. Principals' perceptions of the motivation potential of performance ...

    African Journals Online (AJOL)

    The article explores the proposed performance agreement and its potential influence on principals' motivation to improve their own, and therefore also the teachers' and learners' academic performance. The focus group interviews conducted with principals and deputy principals indicate that principals do not want to be held ...

  19. Management Of Indiscipline Among Teachers By Principals Of ...

    African Journals Online (AJOL)

    This study compared the management of indiscipline among teachers by public and private school principals in Akwa Ibom State. The sample comprised four hundred and fifty (450) principals/vice principals randomly selected from a population of one thousand, four hundred and twenty eight (1,428) principals. The null ...

  20. 21 CFR 701.10 - Principal display panel.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Principal display panel. 701.10 Section 701.10...) COSMETICS COSMETIC LABELING Package Form § 701.10 Principal display panel. The term principal display panel... for retail sale. The principal display panel shall be large enough to accommodate all the mandatory...

  1. The Europa Ocean Discovery mission

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others

    1997-06-01

    Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.

  2. Do Qualification, Experience and Age Matter for Principals Leadership Styles?

    OpenAIRE

    Muhammad Javed Sawati; Saeed Anwar; Muhammad Iqbal Majoka

    2013-01-01

    The main focus of present study was to find out the prevalent leadership styles of principals in government schools of Khyber Pakhtunkhwa and to find relationship of leadership styles with qualifications, age and experience of the principals. On the basis of analyzed data, four major leadership styles of the principals were identified as Eclectic, Democratic, Autocratic, and Free-rein. However, a small proportion of the principal had no dominant leadership style. This study shows that princip...

  3. Trust Me, Principal, or Burn Out! The Relationship between Principals' Burnout and Trust in Students and Parents

    Science.gov (United States)

    Ozer, Niyazi

    2013-01-01

    The purpose of this study was to determine the primary school principals' views on trust in students and parents and also, to explore the relationships between principals' levels of professional burnout and their trust in students and parents. To this end, Principal Trust Survey and Friedman Principal Burnout scales were administered on 119…

  4. A Study of the Perceptions of Performance Skills of Middle School Principals by Selected Teachers and Principals.

    Science.gov (United States)

    Meyer, Calvin F.; Van Hoose, John J.

    This study investigates hypotheses about differences in the perceptions of middle school principals and teachers concerning those principal performance skills that are practiced and those that should be practiced. A survey instrument consisting of 37 principal performance skills on a five-point Likert-like scale was sent to the principals and…

  5. Discovery and Innovation: Submissions

    African Journals Online (AJOL)

    Special emphasis will be given to research and development, both in the humanities and natural sciences as well as the latter's interface with the social sciences, particularly as they relate to major areas of concern in Africa. Articles being considered for publication elsewhere or published previously will not be considered.

  6. Principal-value resummation for dilepton production

    International Nuclear Information System (INIS)

    Contopanagos, H.; Alvero, L.; Sterman, G.

    1994-01-01

    We present a new method of resummation of QCD threshold distributions to the hard scattering function of the dilepton production cross section in hadron-hadron collisions. Our formulation by-passes the infrared singularities of the QCD running coupling through a principal value prescription, and does not require an explicit infrared cut-off. The resulting large corrections exponentiate, and we discuss asymptotic properties of the exponent. We present a closed analytical formula for the resummed hard part in momentum space, and give predictions, at fixed-target energies, for the resulting cross section which is a bounded function of its kinematic variables in the entire partonic phase space

  7. Kernel principal component analysis for change detection

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Morton, J.C.

    2008-01-01

    Principal component analysis (PCA) is often used to detect change over time in remotely sensed images. A commonly used technique consists of finding the projections along the two eigenvectors for data consisting of two variables which represent the same spectral band covering the same geographical...... region acquired at two different time points. If change over time does not dominate the scene, the projection of the original two bands onto the second eigenvector will show change over time. In this paper a kernel version of PCA is used to carry out the analysis. Unlike ordinary PCA, kernel PCA...

  8. Integration of distributed computing into the drug discovery process.

    Science.gov (United States)

    von Korff, Modest; Rufener, Christian; Stritt, Manuel; Freyss, Joel; Bär, Roman; Sander, Thomas

    2011-02-01

    Grid computing offers an opportunity to gain massive computing power at low costs. We give a short introduction into the drug discovery process and exemplify the use of grid computing for image processing, docking and 3D pharmacophore descriptor calculations. The principle of a grid and its architecture are briefly explained. More emphasis is laid on the issues related to a company-wide grid installation and embedding the grid into the research process. The future of grid computing in drug discovery is discussed in the expert opinion section. Most needed, besides reliable algorithms to predict compound properties, is embedding the grid seamlessly into the discovery process. User friendly access to powerful algorithms without any restrictions, that is, by a limited number of licenses, has to be the goal of grid computing in drug discovery.

  9. Label-free drug discovery

    Directory of Open Access Journals (Sweden)

    Ye eFang

    2014-03-01

    Full Text Available Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed interest. However, owing to the intrinsic complexity in drug-target interactions, there is often a significant gap between the phenotype screened and the ultimate molecular mechanism of action sought. This paper presents a label-free strategy for early drug discovery. This strategy combines label-free cell phenotypic profiling with computational approaches, and holds promise to bridge the gap by offering a kinetic and holistic representation of the functional consequences of drugs in disease relevant cells that is amenable to mechanistic deconvolution.

  10. Deep Learning in Drug Discovery.

    Science.gov (United States)

    Gawehn, Erik; Hiss, Jan A; Schneider, Gisbert

    2016-01-01

    Artificial neural networks had their first heyday in molecular informatics and drug discovery approximately two decades ago. Currently, we are witnessing renewed interest in adapting advanced neural network architectures for pharmaceutical research by borrowing from the field of "deep learning". Compared with some of the other life sciences, their application in drug discovery is still limited. Here, we provide an overview of this emerging field of molecular informatics, present the basic concepts of prominent deep learning methods and offer motivation to explore these techniques for their usefulness in computer-assisted drug discovery and design. We specifically emphasize deep neural networks, restricted Boltzmann machine networks and convolutional networks. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Bioinformatics in translational drug discovery.

    Science.gov (United States)

    Wooller, Sarah K; Benstead-Hume, Graeme; Chen, Xiangrong; Ali, Yusuf; Pearl, Frances M G

    2017-08-31

    Bioinformatics approaches are becoming ever more essential in translational drug discovery both in academia and within the pharmaceutical industry. Computational exploitation of the increasing volumes of data generated during all phases of drug discovery is enabling key challenges of the process to be addressed. Here, we highlight some of the areas in which bioinformatics resources and methods are being developed to support the drug discovery pipeline. These include the creation of large data warehouses, bioinformatics algorithms to analyse 'big data' that identify novel drug targets and/or biomarkers, programs to assess the tractability of targets, and prediction of repositioning opportunities that use licensed drugs to treat additional indications. © 2017 The Author(s).

  12. In defence of discovery learning.

    Science.gov (United States)

    Vereijken, B; Whiting, H T

    1990-06-01

    The present paper discusses the influence of different training methods--i.e., knowledge of results, preferred frequency, and the availability of a model--on the learning of a complex motor skill, in this case the learning of slalom ski-type movements on a ski-simulator. Results of three experiments performed on this apparatus showed that, although the training methods used influence the course of learning, none of the methods used was actually superior to discovery learning. It is suggested that discovery learning forces the learner to explore the dynamics of the system in which he or she operates, in an iterative way. Possibilities for cooperative working between prescription and discovery learning are discussed.

  13. Efficient training of multilayer perceptrons using principal component analysis

    International Nuclear Information System (INIS)

    Bunzmann, Christoph; Urbanczik, Robert; Biehl, Michael

    2005-01-01

    A training algorithm for multilayer perceptrons is discussed and studied in detail, which relates to the technique of principal component analysis. The latter is performed with respect to a correlation matrix computed from the example inputs and their target outputs. Typical properties of the training procedure are investigated by means of a statistical physics analysis in models of learning regression and classification tasks. We demonstrate that the procedure requires by far fewer examples for good generalization than traditional online training. For networks with a large number of hidden units we derive the training prescription which achieves, within our model, the optimal generalization behavior

  14. Current aspects of the principal of protecting employees

    Directory of Open Access Journals (Sweden)

    Jovanović Predrag

    2011-01-01

    Full Text Available The principal of protecting employees is traditionally present in labor law. Particular categories of employees, also traditionally, enjoy special protection (young people, women, the disabled. However, the issue of protection of moral integrity of the employees has only recently been addressed. That makes the general principle of the protection of employees in labor relations very current, and it is from that perspective that this paper points out to certain standards of protection of employees in light of international, European and domestic law.

  15. Advancements in Aptamer Discovery Technologies.

    Science.gov (United States)

    Gotrik, Michael R; Feagin, Trevor A; Csordas, Andrew T; Nakamoto, Margaret A; Soh, H Tom

    2016-09-20

    Affinity reagents that specifically bind to their target molecules are invaluable tools in nearly every field of modern biomedicine. Nucleic acid-based aptamers offer many advantages in this domain, because they are chemically synthesized, stable, and economical. Despite these compelling features, aptamers are currently not widely used in comparison to antibodies. This is primarily because conventional aptamer-discovery techniques such as SELEX are time-consuming and labor-intensive and often fail to produce aptamers with comparable binding performance to antibodies. This Account describes a body of work from our laboratory in developing advanced methods for consistently producing high-performance aptamers with higher efficiency, fewer resources, and, most importantly, a greater probability of success. We describe our efforts in systematically transforming each major step of the aptamer discovery process: selection, analysis, and characterization. To improve selection, we have developed microfluidic devices (M-SELEX) that enable discovery of high-affinity aptamers after a minimal number of selection rounds by precisely controlling the target concentration and washing stringency. In terms of improving aptamer pool analysis, our group was the first to use high-throughput sequencing (HTS) for the discovery of new aptamers. We showed that tracking the enrichment trajectory of individual aptamer sequences enables the identification of high-performing aptamers without requiring full convergence of the selected aptamer pool. HTS is now widely used for aptamer discovery, and open-source software has become available to facilitate analysis. To improve binding characterization, we used HTS data to design custom aptamer arrays to measure the affinity and specificity of up to ∼10(4) DNA aptamers in parallel as a means to rapidly discover high-quality aptamers. Most recently, our efforts have culminated in the invention of the "particle display" (PD) screening system, which

  16. Influence of Intermediate Principal Stress on Undrained Behavior of Intact Clay under Pure Principal Stress Rotation

    Directory of Open Access Journals (Sweden)

    Jian Zhou

    2013-01-01

    Full Text Available This study presents the accumulations of the excess pore water pressure and the deformation as well as the noncoaxial behavior of intact soft clay subjected to pure principal stress rotation. Series of tests were carried out by using a dynamic hollow cylinder apparatus to highlight the influence of intermediate principal stress parameter b. It was found that the rate of PWP evolution was greatly influenced by b, but the influence was not monotonous. Specimens under the condition b = 0.75 had the highest accumulation of pore water pressure while under the condition b = 0 had the strongest resistance to the pore pressure generation. PWP accumulated mainly in the first cycle. The failure of specimens under principal stress rotation was controlled by the strain other than the pore pressure. The shear stiffness decreased more quickly with higher b value. The direction of the principal strain increment was strongly dependent on the principal stress increment orientation and less influenced by the b value and the number of cycles.

  17. Motif discovery in ranked lists of sequences

    DEFF Research Database (Denmark)

    Nielsen, Morten Muhlig; Tataru, Paula; Madsen, Tobias

    2016-01-01

    a growing need for motif analysis methods that can exploit this coupled data structure and be tailored for specific biological questions. Here, we present an exploratory motif analysis tool, Regmex (REGular expression Motif EXplorer), which offers several methods to evaluate the correlation of motifs....... These features make Regmex well suited for a range of biological sequence analysis problems related to motif discovery, exemplified by microRNA seed enrichment, but also including enrichment problems involving complex motifs and combinations of motifs. We demonstrate a number of usage scenarios that take...

  18. Hubble 15 years of discovery

    CERN Document Server

    Lindberg Christensen, Lars; Kornmesser, M

    2006-01-01

    Hubble: 15 Years of Discovery was a key element of the European Space Agency's 15th anniversary celebration activities for the 1990 launch of the NASA/ESA Hubble Space Telescope. As an observatory in space, Hubble is one of the most successful scientific projects of all time, both in terms of scientific output and its immediate public appeal.

  19. Smartphones: A Potential Discovery Tool

    Directory of Open Access Journals (Sweden)

    Wendy Starkweather

    2009-09-01

    Full Text Available The anticipated wide adoption of smartphones by researchers is viewed by the authors as a basis for developing mobile-based services. In response to the UNLV Libraries’ strategic plan’s focus on experimentation and outreach, the authors investigate the current and potential role of smartphones as a valuable discovery tool for library users.

  20. Translational medicine and drug discovery

    National Research Council Canada - National Science Library

    Littman, Bruce H; Krishna, Rajesh

    2011-01-01

    ..., and examples of their application to real-life drug discovery and development. The latest thinking is presented by researchers from many of the world's leading pharmaceutical companies, including Pfizer, Merck, Eli Lilly, Abbott, and Novartis, as well as from academic institutions and public- private partnerships that support translational research...

  1. Structural Biology Guides Antibiotic Discovery

    Science.gov (United States)

    Polyak, Steven

    2014-01-01

    Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…

  2. A Discovery Approach to Movement.

    Science.gov (United States)

    O'Hagin, Isabel B.

    1998-01-01

    Investigates the effects of the discovery approach to movement-based instruction on children's level of musicality. Finds that the students with the highest musicality were girls, demonstrated reflective movements and a personal sense of style while moving, and made sense of the music by organizing, categorizing, and developing movement ideas.…

  3. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    activities as the potential discovery of elements heavier than uranium [5]. He drew this conclusion ... alkaline earth metals in the irradiation of uranium by neutrons) Hahn and Strassmann did. 458. Pramana – J. ... the production of active barium isotopes from uranium and thorium by neutron irradiation;. Proof of further active ...

  4. Integrating Data Transformation in Principal Components Analysis

    KAUST Repository

    Maadooliat, Mehdi

    2015-01-02

    Principal component analysis (PCA) is a popular dimension reduction method to reduce the complexity and obtain the informative aspects of high-dimensional datasets. When the data distribution is skewed, data transformation is commonly used prior to applying PCA. Such transformation is usually obtained from previous studies, prior knowledge, or trial-and-error. In this work, we develop a model-based method that integrates data transformation in PCA and finds an appropriate data transformation using the maximum profile likelihood. Extensions of the method to handle functional data and missing values are also developed. Several numerical algorithms are provided for efficient computation. The proposed method is illustrated using simulated and real-world data examples.

  5. Reinvention and the Principal-Agent Model

    Directory of Open Access Journals (Sweden)

    J. Ramón Gil García

    2003-01-01

    Full Text Available Existe una interesante polémica en el sector público, derivada de las tensiones existentes entre desempeño y flexibilidad administrativa por un lado, y rendición de cuentas y control, por el otro. El propósito de este artículo es discutir la utilidad del modelo agente principal para un mejor entendimiento de las tensiones entre desempeño y rendición de cuentas, así como analizar las similitudes y contradicciones de esta perspectiva teórica en comparación con el movimiento de “reinvención del gobierno” de la década de los noventa en Estados Unidos.

  6. The discovery uncovered

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Almost exactly one hundred years after the publication of Einstein’s paper on General Relativity, the LIGO and Virgo collaborations have published a paper in which they show a gravitational signal emitted by the merger of two black holes. The signal has been observed with 5-sigma accuracy and is the first direct observation of gravitational waves.   On Thursday, 11 February, Barry Clark Barish, one of the fathers of the LIGO experiment, presented the latest results in a packed Auditorium. Ripples in space-time, the fabric of the Universe: this is how we can picture gravitational waves. In his visionary paper published in June 1916, Einstein predicted that masses deform space-time and, therefore, any change in their position causes a distortion that propagates at the speed of light, resulting in gravitational waves.   It wasn’t until 1975, almost 60 years later, that Russell Hulse and Joseph Taylor, who were awarded the Nobel Prize in 1993, inferred t...

  7. Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers.

    Directory of Open Access Journals (Sweden)

    Y-h Taguchi

    Full Text Available The discovery and characterization of blood-based disease biomarkers are clinically important because blood collection is easy and involves relatively little stress for the patient. However, blood generally reflects not only targeted diseases, but also the whole body status of patients. Thus, the selection of biomarkers may be difficult. In this study, we considered miRNAs as biomarker candidates for several reasons. First, since miRNAs were discovered relatively recently, they have not yet been tested extensively. Second, since the number of miRNAs is relatively limited, selection is expected to be easy. Third, since they are known to play critical roles in a wide range of biological processes, their expression may be disease specific. We applied a newly proposed method to select combinations of miRNAs that discriminate between healthy controls and each of 14 diseases that include 5 cancers. A new feature selection method is based on principal component analysis. Namely this method does not require knowledge of whether each sample was derived from a disease patient or a healthy control. Using this method, we found that hsa-miR-425, hsa-miR-15b, hsa-miR-185, hsa-miR-92a, hsa-miR-140-3p, hsa-miR-320a, hsa-miR-486-5p, hsa-miR-16, hsa-miR-191, hsa-miR-106b, hsa-miR-19b, and hsa-miR-30d were potential biomarkers; combinations of 10 of these miRNAs allowed us to discriminate each disease included in this study from healthy controls. These 12 miRNAs are significantly up- or downregulated in most cancers and other diseases, albeit in a cancer- or disease-specific combinatory manner. Therefore, these 12 miRNAs were also previously reported to be cancer- and disease-related miRNAs. Many disease-specific KEGG pathways were also significantly enriched by target genes of up-/downregulated miRNAs within several combinations of 10 miRNAs among these 12 miRNAs. We also selected miRNAs that could discriminate one disease from another or from healthy controls

  8. An Approach to Integrating Tactical Decision-Making in Industrial Maintenance Balance Scorecards Using Principal Components Analysis and Machine Learning

    Directory of Open Access Journals (Sweden)

    Néstor Rodríguez-Padial

    2017-01-01

    Full Text Available The uncertainty of demand has led production systems to become increasingly complex; this can affect the availability of the machines and thus their maintenance. Therefore, it is necessary to adequately manage the information that facilitates decision-making. This paper presents a system for making decisions related to the design of customized maintenance plans in a production plant. This paper addresses this tactical goal and aims to provide greater knowledge and better predictions by projecting reliable behavior in the medium-term, integrating this new functionality into classic Balance Scorecards, and making it possible to extend their current measuring function to a new aptitude: predicting evolution based on historical data. In the proposed Custom Balance Scorecard design, an exploratory data phase is integrated with another analysis and prediction phase using Principal Component Analysis algorithms and Machine Learning that uses Artificial Neural Network algorithms. This new extension allows better control over the maintenance function of an industrial plant in the medium-term with a yearly horizon taken over monthly intervals which allows the measurement of the indicators of strategic productive areas and the discovery of hidden behavior patterns in work orders. In addition, this extension enables the prediction of indicator outcomes such as overall equipment efficiency and mean time to failure.

  9. Principals and the Human Condition: Reflections of an Elementary School Principal.

    Science.gov (United States)

    Latimer, Milree H.

    Educational leaders must be perceived to act consistently and with integrity. When leaders are conscious of beliefs and values, they will act spontaneously in a consistent manner, and their actions, embedded in their beliefs, will have an underlying harmony. School principals must embrace the concept of empowerment and dignity of the individual…

  10. The Networked Principal: Examining Principals' Social Relationships and Transformational Leadership in School and District Networks

    Science.gov (United States)

    Moolenaar, Nienke M.; Sleegers, Peter J. C.

    2015-01-01

    Purpose: While in everyday practice, school leaders are often involved in social relationships with a variety of stakeholders both within and outside their own schools, studies on school leaders' networks often focus either on networks within or outside schools. The purpose of this paper is to investigate the extent to which principals occupy…

  11. Principals' and Teachers' Views of Spirituality in Principal Leadership in Three Primary Schools

    Science.gov (United States)

    Gibson, Alaster

    2014-01-01

    This article discusses key findings from my doctoral research involving a qualitative case study inquiring into the lived experiences of spirituality in principal leadership and its influence on teachers and their teaching within three public primary school contexts in New Zealand. Spirituality is understood in this article as a complex and…

  12. 10 CFR 609.13 - Principal and interest assistance contract.

    Science.gov (United States)

    2010-01-01

    ... THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.13 Principal and interest assistance contract. With respect... appropriated for that purpose, the principal and interest charges that become due and payable on the unpaid...

  13. Visions of Discovery

    Science.gov (United States)

    Chiao, Raymond Y.; Cohen, Marvin L.; Leggett, Anthony J.; Phillips, William D.; Harper, Charles L., Jr.

    2010-10-01

    physics? Steven Chu; 20. Quantum information J. Ignacio Cirac; 21. Emergence in condensed matter physics Marvin L. Cohen; 22. Achieving the highest spectral resolution over the widest spectral bandwidth: precision measurement meets ultrafast science Jun Ye; 23. Wireless non-radiative energy transfer Marin Soljačić; Part V. Consciousness and Free Will: 24. The big picture: exploring questions on the boundaries of science - consciousness and free will George F. R. Ellis; 25. Quantum entanglement: from fundamental questions to quantum communication and quantum computation and back Anton Zeilinger; 26. Consciousness, body, and brain: the matter of the mind Gerald M. Edelman; 27. The relation between quantum mechanics and higher brain functions: lessons from quantum computation and neurobiology Christof Koch and Klaus Hepp; 28. Free will and the causal closure of physics Robert C. Bishop; 29. Natural laws and the closure of physics Nancy L. Cartwright; 30. Anti-Cartesianism and downward causation: reshaping the free-will debate Nancey Murphy; 31. Can we understand free will? Charles H. Townes; Part VI. Reflections on the Big Questions: Mind, Matter. Mathematics, and Ultimate Reality: 32. The big picture: exploring questions on the boundaries of science - mind, matter, mathematics George F. R. Ellis; 33. The mathematical universe Max Tegmark; 34. Where do the laws of physics come from? Paul C. W. Davies; 35. Science, energy, ethics, and civilization Vaclav Smil; 36. Life of science, life of faith William T. Newsome; 37. The science of light and the light of science: an appreciative theological reflection on the life and work of Charles Hard Townes Robert J. Russell; 38. Two quibbles about 'ultimate' Gerald Gabrielse; Index.

  14. Arthritis Genetics Analysis Aids Drug Discovery

    Science.gov (United States)

    ... NIH Research Matters January 13, 2014 Arthritis Genetics Analysis Aids Drug Discovery An international research team identified 42 new ... Edition Distracted Driving Raises Crash Risk Arthritis Genetics Analysis Aids Drug Discovery Oxytocin Affects Facial Recognition Connect with Us ...

  15. The Principal's Perceptions of School Libraries and Teacher-Librarians.

    Science.gov (United States)

    Hartzell, Gary

    2002-01-01

    Discusses principals' inaccurate perceptions of school library media programs and teacher-librarians. Topics include the invisibility of media specialists; isolation and scheduling; a low profile in professional literature read by principals; occupational socialization; principals' experiences as K-12 students; teacher training; administrator…

  16. Principal Selection: A National Study of Selection Criteria and Procedures

    Science.gov (United States)

    Palmer, Brandon

    2017-01-01

    Despite empirical evidence correlating the role of the principal with student achievement, researchers have seldom scrutinized principal selection methods over the past 60 years. This mixed methods study investigated the processes by which school principals are selected. A national sample of top-level school district administrators was used to…

  17. How Professional Standards Guide Practice for School Principals

    Science.gov (United States)

    Militello, Matthew; Fusarelli, Bonnie; Alsbury, Thomas; Warren, Thomas P.

    2013-01-01

    Purpose: The purpose of this study is to provide an empirical measure of how principals enact prescribed leadership standards into practice. The aim of the study was to ascertain how current school principals perceive the practice of a specific set of leadership standards. Design/methodology/approach: A total of 61 practicing school principals in…

  18. Principals' Experiences of Being Evaluated: A Phenomenological Study

    Science.gov (United States)

    Parylo, Oksana; Zepeda, Sally J.; Bengtson, Ed

    2012-01-01

    This phenomenological study sought to understand principals' lived experiences of being evaluated with reliance on the principles of developmental supervision and adult learning theory. Analysis of interview data from 16 principals revealed 3 major constructs in principal evaluation: evaluation is a complex, constantly changing system; principal…

  19. Perception of principals and teachers of the external supervisors ...

    African Journals Online (AJOL)

    The study investigated the perception of principals and teachers of external supervisors' role in secondary schools in Ogun State. Two versions of a questionnaire titled “Questionnaire on the role of external supervisors as perceived by principals and teachers” designed by the researcher were administered on 40 principals ...

  20. Job Satisfaction of Elementary Principals in Large Urban Communities

    Science.gov (United States)

    Mitchell, Cathryn M.

    2010-01-01

    The purpose of this study was to determine job satisfaction levels of elementary principals in "major urban" districts in Texas and to identify strategies these principals used to cope with the demands of the position. Additionally, the project sought to find structures and supports needed to attract and retain principals in the…

  1. Contemporary Challenges and Changes: Principals' Leadership Practices in Malaysia

    Science.gov (United States)

    Jones, Michelle; Adams, Donnie; Joo, Mabel Tan Hwee; Muniandy, Vasu; Perera, Corinne Jaqueline; Harris, Alma

    2015-01-01

    This article outlines the findings from a contemporary study of principals' leadership practices in Malaysia as part of the 7 System Leadership Study. Recent policy developments within Malaysia have increased principals' accountability and have underlined the importance of the role of the principals in transforming school performance and student…

  2. Principal Leadership for Technology-enhanced Learning in Science

    Science.gov (United States)

    Gerard, Libby F.; Bowyer, Jane B.; Linn, Marcia C.

    2008-02-01

    Reforms such as technology-enhanced instruction require principal leadership. Yet, many principals report that they need help to guide implementation of science and technology reforms. We identify strategies for helping principals provide this leadership. A two-phase design is employed. In the first phase we elicit principals' varied ideas about the Technology-enhanced Learning in Science (TELS) curriculum materials being implemented by teachers in their schools, and in the second phase we engage principals in a leadership workshop designed based on the ideas they generated. Analysis uses an emergent coding scheme to categorize principals' ideas, and a knowledge integration framework to capture the development of these ideas. The analysis suggests that principals frame their thinking about the implementation of TELS in terms of: principal leadership, curriculum, educational policy, teacher learning, student outcomes and financial resources. They seek to improve their own knowledge to support this reform. The principals organize their ideas around individual school goals and current political issues. Principals prefer professional development activities that engage them in reviewing curricula and student work with other principals. Based on the analysis, this study offers guidelines for creating learning opportunities that enhance principals' leadership abilities in technology and science reform.

  3. Common Core Implementation Decisions Made by Principals in Elementary Schools

    Science.gov (United States)

    Norman, Alexis Cienfuegos

    2016-01-01

    The purpose of this study was to understand the decisions elementary principals have made during the Common Core State Standards reform. Specifically, (a) what decisions principals have made to support Common Core implementation, (b) what strategies elementary principals have employed to communicate with stakeholders about Common Core State…

  4. FY15 Sao Tome and Principe Country Opinion Survey Report

    OpenAIRE

    World Bank Group

    2016-01-01

    The Country Opinion Survey in Sao Tome and Principe assists the World Bank Group (WBG) in gaining a better understanding of how stakeholders in Sao Tome and Principe perceive the WBG. It provides the WBG with systematic feedback from national and local governments, multilateral/bilateral agencies, media, academia, the private sector, and civil society in Sao Tome and Principe on 1) their v...

  5. The Development of Assistant Principals: A Literature Review

    Science.gov (United States)

    Oleszewski, Ashley; Shoho, Alan; Barnett, Bruce

    2012-01-01

    Purpose: The purpose of this review is to add to the discussion of assistant principals (APs), a position that has been under-represented in the professional literature. Design/methodology/approach: An extensive search was undertaken on assistant principals, vice principals, and deputy head teachers from various sources, including journals,…

  6. School Performance Trajectories and the Challenges for Principal Succession

    Science.gov (United States)

    Lee, Linda C.

    2015-01-01

    Purpose: The purpose of this paper is to use empirical data on new principals to clarify the connection between different succession situations and the challenges their successor principals face. Design/methodology/approach: The study draws on two waves of interview data from a random sample of 16 new elementary school principals in a major urban…

  7. The Principal Report: The State of School Leadership in Illinois

    Science.gov (United States)

    White, Bradford R.; Agarwal, Pooja K.

    2011-01-01

    Although principals play a vital role as school leaders, exactly how principal leadership affects student learning is only beginning to be understood. In fact, only a few states have analyzed basic profile data on their principals--their demographics, education, and prior experience before leading a school. Most states also have yet to examine how…

  8. Entry Strategies of First-Time High School Principals.

    Science.gov (United States)

    Hall, Gene E.; Mani, M. N. G.

    To determine the first things that a new principal does during the first few months on the job, an intensive case study was conducted of 12 first-time high school principals in Florida, Virginia, Missouri, and Colorado. Each beginning principal was assigned a research team member who conducted on-site visits, reviewed documentation regarding the…

  9. Principals' Perceptions of Instructional Stages Based on Felt Teaching Characteristics.

    Science.gov (United States)

    DeMoulin, Donald F.; Guyton, John W.

    Whether principals could identify teaching traits and categorize these consistently as descriptors of instructional stages was studied by asking 145 randomly selected principals in public schools throughout Illinois and Indiana to characterize teacher behavior based on experience. Principals were asked to list instructional stages, yielding 161…

  10. 21 CFR 801.60 - Principal display panel.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Principal display panel. 801.60 Section 801.60... panel. The term principal display panel, as it applies to over-the-counter devices in package form and..., or examined under customary conditions of display for retail sale. The principal display panel shall...

  11. 21 CFR 201.60 - Principal display panel.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Principal display panel. 201.60 Section 201.60...: GENERAL LABELING Labeling Requirements for Over-the-Counter Drugs § 201.60 Principal display panel. The term principal display panel, as it applies to over-the-counter drugs in package form and as used in...

  12. Use of Sparse Principal Component Analysis (SPCA) for Fault Detection

    DEFF Research Database (Denmark)

    Gajjar, Shriram; Kulahci, Murat; Palazoglu, Ahmet

    2016-01-01

    Principal component analysis (PCA) has been widely used for data dimension reduction and process fault detection. However, interpreting the principal components and the outcomes of PCA-based monitoring techniques is a challenging task since each principal component is a linear combination of the ...

  13. [Artificial Intelligence in Drug Discovery].

    Science.gov (United States)

    Fujiwara, Takeshi; Kamada, Mayumi; Okuno, Yasushi

    2018-04-01

    According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI. In addition, with the aim of creating new therapeutic targets in genomic drug discovery, we have been also working on the development of a binding affinity prediction system for mutated proteins and drugs by molecular dynamics simulation using supercomputer "Kei". We also have tackled for problems in a drug virtual screening. Our developed AI technology has successfully generated virtual compound library, and deep learning method has enabled us to predict interaction between compound and target protein.

  14. Glycoscience aids in biomarker discovery

    Directory of Open Access Journals (Sweden)

    Serenus Hua1,2 & Hyun Joo An1,2,*

    2012-06-01

    Full Text Available The glycome consists of all glycans (or carbohydrates within abiological system, and modulates a wide range of important biologicalactivities, from protein folding to cellular communications.The mining of the glycome for disease markers representsa new paradigm for biomarker discovery; however, this effortis severely complicated by the vast complexity and structuraldiversity of glycans. This review summarizes recent developmentsin analytical technology and methodology as applied tothe fields of glycomics and glycoproteomics. Mass spectrometricstrategies for glycan compositional profiling are described, as arepotential refinements which allow structure-specific profiling.Analytical methods that can discern protein glycosylation at aspecific site of modification are also discussed in detail.Biomarker discovery applications are shown at each level ofanalysis, highlighting the key role that glycoscience can play inhelping scientists understand disease biology.

  15. Enteric Neurobiology: Discoveries and Directions.

    Science.gov (United States)

    Wood, Jackie D

    Discovery and documentation of noncholinergic-nonadrenergic neurotransmission in the enteric nervous system started a revolution in mechanisms of neural control of the digestive tract that continues into a twenty-first century era of translational gastroenterology, which is now firmly embedded in the term, neurogastroenterology. This chapter, on Enteric Neurobiology: Discoveries and Directions, tracks the step-by-step advances in enteric neuronal electrophysiology and synaptic behavior and progresses to the higher order functions of central pattern generators, hard wired synaptic circuits and libraries of neural programs in the brain-in-the-gut that underlie the several different patterns of motility and secretory behaviors that occur in the specialized, serially-connected compartments extending from the esophagus to the anus.

  16. The discovery of immunoglobulin E.

    Science.gov (United States)

    Ribatti, Domenico

    2016-03-01

    The discovery of immunoglobulin E (IgE) was a breakthrough in the field of allergy and immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. The first clue to the existence of a substance responsible for hypersensitivity reactions was demonstrated in 1921 by Prausnitz and Kustner, and after four decades it was identified as an immunoglobulin subclass by Ishizakas and co-workers. In 1968, the WHO International Reference Centre for Immunoglobulins announced the presence of a fifth immunoglobulin isotype, IgE. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Androgenetic alopecia: stress of discovery.

    Science.gov (United States)

    Passchier, Jan; Erdman, Jeroen; Hammiche, Fatima; Erdman, Ruud A M

    2006-02-01

    The psychological problems of men in the initial stages of alopecia androgenetica (hereditary male hair loss) have seldom been studied. We evaluated two groups of 80 men with alopecia androgenetica in Stages II to IV, indicating the amount of hair loss (overall N=160; for Group I: M=48 yr., SD=18.2; for Group II: M=50 yr., SD=18.0) who visited a dermatology clinic for benign dermatological complaints but not for hair loss, by questionnaires and interview, retrospectively. As predicted, hair problems were reported to be significantly greater overall at the moment of discovery of hair loss than later. About half of the men reported feeling annoyed to very annoyed about the discovery of hair loss. For those patients, provision of information by internet might facilitate a visit to the dermatologist.

  18. 12 CFR 308.107 - Document discovery.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Document discovery. 308.107 Section 308.107... PRACTICE AND PROCEDURE General Rules of Procedure § 308.107 Document discovery. (a) Parties to proceedings... only through the production of documents. No other form of discovery shall be allowed. (b) Any...

  19. 34 CFR 81.16 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Discovery. 81.16 Section 81.16 Education Office of the... voluntarily. (b) The ALJ, at a party's request, may order compulsory discovery described in paragraph (c) of... respect to an issue in the case; (3) The discovery request was not made primarily for the purposes of...

  20. 42 CFR 426.532 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... purpose of this section, the term documents includes relevant information, reports, answers, records... § 426.532 Discovery. (a) General rule. If the Board orders discovery, the Board must establish a... or burdensome; or (iii) Will unduly delay the proceeding. (c) Types of discovery available. A party...

  1. The discovery of the antiproton

    International Nuclear Information System (INIS)

    Chamberlain, Owen

    1989-01-01

    A number of groups of particle physicists competed to provide track evidence of the existence of Dirac's postulated antiproton in the mid-1950s. The work of the several teams is described briefly. The author describes the work of his own group on the Bevatron in more detail, and how they finally observed the antiproton. The article finishes with an assessment of the importance of this discovery. (UK)

  2. Model organisms and target discovery.

    Science.gov (United States)

    Muda, Marco; McKenna, Sean

    2004-09-01

    The wealth of information harvested from full genomic sequencing projects has not generated a parallel increase in the number of novel targets for therapeutic intervention. Several pharmaceutical companies have realized that novel drug targets can be identified and validated using simple model organisms. After decades of service in basic research laboratories, yeasts, worms, flies, fishes, and mice are now the cornerstones of modern drug discovery programs.: © 2004 Elsevier Ltd . All rights reserved.

  3. Gas reserves, discoveries and production

    International Nuclear Information System (INIS)

    Saniere, A.

    2006-01-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  4. Sparse principal component analysis in medical shape modeling

    Science.gov (United States)

    Sjöstrand, Karl; Stegmann, Mikkel B.; Larsen, Rasmus

    2006-03-01

    Principal component analysis (PCA) is a widely used tool in medical image analysis for data reduction, model building, and data understanding and exploration. While PCA is a holistic approach where each new variable is a linear combination of all original variables, sparse PCA (SPCA) aims at producing easily interpreted models through sparse loadings, i.e. each new variable is a linear combination of a subset of the original variables. One of the aims of using SPCA is the possible separation of the results into isolated and easily identifiable effects. This article introduces SPCA for shape analysis in medicine. Results for three different data sets are given in relation to standard PCA and sparse PCA by simple thresholding of small loadings. Focus is on a recent algorithm for computing sparse principal components, but a review of other approaches is supplied as well. The SPCA algorithm has been implemented using Matlab and is available for download. The general behavior of the algorithm is investigated, and strengths and weaknesses are discussed. The original report on the SPCA algorithm argues that the ordering of modes is not an issue. We disagree on this point and propose several approaches to establish sensible orderings. A method that orders modes by decreasing variance and maximizes the sum of variances for all modes is presented and investigated in detail.

  5. Palynological applications of principal component and cluster analyses

    Science.gov (United States)

    Adam, David P.

    1974-01-01

    Two multivariate statistical methods are suggested to help describe patterns in pollen data that result from changes in the relative frequencies of pollen types produced by past climatic and environmental variations. These methods, based on a geometric model, compare samples by use of the product-moment correlation coefficient computed from data subjected to a centering transformation. If there are m samples and n pollen types, then the data can be regarded as a set of m points in an n-dimensional space. The first method, cluster analysis, produces a dendrograph or clustering tree in which samples are grouped with other samples on the basis of their similarity to each other. The second method, principal component analysis, produces a set of variates that arc linear combinations of the pollen samples, are uncorrelated with each other, and best describe the data using a minimum number of dimensions. This method is useful in reducing the dimensionality of data sets. A further transformation known as varimax rotation acts on a subset of the principal components to make them easier to interpret. Both methods offer the advantages of reproducibility of results and speed in pattern description. Once the patterns in the data have been described, however, they must be interpreted by the palynologist. An application of the methods in palynology is shown by using data from Osgood Swamp, Calif.

  6. Functional Principal Components Analysis of Shanghai Stock Exchange 50 Index

    Directory of Open Access Journals (Sweden)

    Zhiliang Wang

    2014-01-01

    Full Text Available The main purpose of this paper is to explore the principle components of Shanghai stock exchange 50 index by means of functional principal component analysis (FPCA. Functional data analysis (FDA deals with random variables (or process with realizations in the smooth functional space. One of the most popular FDA techniques is functional principal component analysis, which was introduced for the statistical analysis of a set of financial time series from an explorative point of view. FPCA is the functional analogue of the well-known dimension reduction technique in the multivariate statistical analysis, searching for linear transformations of the random vector with the maximal variance. In this paper, we studied the monthly return volatility of Shanghai stock exchange 50 index (SSE50. Using FPCA to reduce dimension to a finite level, we extracted the most significant components of the data and some relevant statistical features of such related datasets. The calculated results show that regarding the samples as random functions is rational. Compared with the ordinary principle component analysis, FPCA can solve the problem of different dimensions in the samples. And FPCA is a convenient approach to extract the main variance factors.

  7. Discovery of a Makemakean Moon

    Science.gov (United States)

    Parker, Alex H.; Buie, Marc W.; Grundy, Will M.; Noll, Keith S.

    2016-01-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope's Wide Field Camera 3 on UTC 2015 April 27 at 7.80 +/- 0.04 mag fainter than Makemake and at a separation of 0farcs57. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days and must have a semimajor axis > or approx. = 21,000 km. We find that the properties of Makemake's moon suggest that the majority of the dark material detected in the system by thermal observations may not reside on the surface of Makemake, but may instead be attributable to S/2015 (136472) 1 having a uniform dark surface. This dark moon hypothesis can be directly tested with future James Webb Space Telescope observations. We discuss the implications of this discovery for the spin state, figure, and thermal properties of Makemake and the apparent ubiquity of trans-Neptunian dwarf planet satellites.

  8. A New Universe of Discoveries

    Science.gov (United States)

    Córdova, France A.

    2016-01-01

    The convergence of emerging advances in astronomical instruments, computational capabilities and talented practitioners (both professional and civilian) is creating an extraordinary new environment for making numerous fundamental discoveries in astronomy, ranging from the nature of exoplanets to understanding the evolution of solar systems and galaxies. The National Science Foundation is playing a critical role in supporting, stimulating, and shaping these advances. NSF is more than an agency of government or a funding mechanism for the infrastructure of science. The work of NSF is a sacred trust that every generation of Americans makes to those of the next generation, that we will build on the body of knowledge we inherit and continue to push forward the frontiers of science. We never lose sight of NSF's obligation to "explore the unexplored" and inspire all of humanity with the wonders of discovery. As the only Federal agency dedicated to the support of basic research and education in all fields of science and engineering, NSF has empowered discoveries across a broad spectrum of scientific inquiry for more than six decades. The result is fundamental scientific research that has had a profound impact on our nation's innovation ecosystem and kept our nation at the very forefront of the world's science-and-engineering enterprise.

  9. Principal component analysis for fermionic critical points

    Science.gov (United States)

    Costa, Natanael C.; Hu, Wenjian; Bai, Z. J.; Scalettar, Richard T.; Singh, Rajiv R. P.

    2017-11-01

    We use determinant quantum Monte Carlo (DQMC), in combination with the principal component analysis (PCA) approach to unsupervised learning, to extract information about phase transitions in several of the most fundamental Hamiltonians describing strongly correlated materials. We first explore the zero-temperature antiferromagnet to singlet transition in the periodic Anderson model, the Mott insulating transition in the Hubbard model on a honeycomb lattice, and the magnetic transition in the 1/6-filled Lieb lattice. We then discuss the prospects for learning finite temperature superconducting transitions in the attractive Hubbard model, for which there is no sign problem. Finally, we investigate finite temperature charge density wave (CDW) transitions in the Holstein model, where the electrons are coupled to phonon degrees of freedom, and carry out a finite size scaling analysis to determine Tc. We examine the different behaviors associated with Hubbard-Stratonovich auxiliary field configurations on both the entire space-time lattice and on a single imaginary time slice, or other quantities, such as equal-time Green's and pair-pair correlation functions.

  10. Record of principal work activities/deliverables

    International Nuclear Information System (INIS)

    1989-09-01

    Over the five year period of performance, thirteen task assignments were issued by the DOE to ARINC Research. During the two year base period seven tasks were assigned. Two task assignments were issued for each of the three consecutive one year option periods. Associated with all task assignments were multiple subtasks, some of which required significant effort. These subtasks are appropriately cited in this report under their respective task assignments as principal work activities or deliverables. The technical and management support provided to the DOE under this contract focused on two general areas: (1) appraisal activities and (2) non-appraisal activities. Support to appraisals included planning, document review, developing lines-of-inquiry, interviewing, data collection, report writing, and follow-up. Such work was executed both on-site at the DOE facility under review and off-site. Non-appraisal support was varied and included such areas as document review, data base development, technical assessments. statistical analysis, policy analysis, reliability engineering, and workshop and conference planning and execution

  11. Perceptions of the Principal Evaluation Process and Performance Criteria: A Qualitative Study of the Challenge of Principal Evaluation

    Science.gov (United States)

    Faginski-Stark, Erica; Casavant, Christopher; Collins, William; McCandless, Jason; Tencza, Marilyn

    2012-01-01

    Recent federal and state mandates have tasked school systems to move beyond principal evaluation as a bureaucratic function and to re-imagine it as a critical component to improve principal performance and compel school renewal. This qualitative study investigated the district leaders' and principals' perceptions of the performance evaluation…

  12. Scientists Like Me: Faces of Discovery

    Science.gov (United States)

    Enevoldsen, A. A. G.; Culp, S.; Trinh, A.

    2010-08-01

    During the International Year of Astronomy, Pacific Science Center is hosting a photography exhibit: Scientists Like Me: Faces of Discovery. The exhibit contains photographs of real, current astronomers and scientists working in astronomy and aerospace-related fields from many races, genders, cultural affiliations and walks of life. The photographs were taken and posters designed by Alyssa Trinh and Sarah Culp, high school interns in Discovery Corps, Pacific Science Center's youth development program. The direct contact between the scientists and the interns helps the intended audience of teachers and families personally connect with scientists. The finished posters from this exhibit are available online (http://pacificsciencecenter.org/scientists) for teachers to use in their classrooms, in addition to being displayed at Pacific Science Center and becoming part of Pacific Science Center's permanent art rotation. The objective of this project was to fill a need for representative photographs of scientists in the world community. It also met two of the goals of International Year of Astronomy: to provide a modern image of science and scientists, and to improve the gender-balanced representation of scientists at all levels and promote greater involvement by all people in scientific and engineering careers. We would like to build on the success of this project and create an annual summer internship, with different interns, focusing on creating posters for different fields of science.

  13. Discovery potential for supersymmetry in CMS

    CERN Document Server

    Abdullin, Salavat; Charles, François; Denegri, Daniel; Dydak, U; Dzelalija, Mile; Genchev, Vladimir; Graham, Douglas Jonathon; Iashvili, Ia; Kharchilava, Avto; Kinnunen, Ritva; Kunori, Shuichi; Mazumdar, Kajari; Racca, Chantal; Rurua, Lali; Stepanov, Nikita; Womersley, J

    2002-01-01

    This work summarizes and puts in an overall perspective studies done within CMS concerning the discovery potential for squarks and gluinos, sleptons, charginos and neutralinos, SUSY dark matter, lightest Higgs, sparticle mass determination methods and the detector design optimisation in view of SUSY searches. It represents the status of our understanding of these subjects as of Summer 1997. As a benchmark model we used the minimal supergravity-inspired super- symmetric standard model (mSUGRA) with a stable LSP. Discovery of SUSY at the LHC should be relatively straightforward. It may occur through the observation of a large excesses of events in missing E_T + jets, or with one or more isolated leptons. An excess of trilepton events or of isolated dileptons with E_T^miss, exhibiting a characteristic signature in the l^+l^- invariant mass distribution could also be the first manifestation of SUSY production. Squark and gluino production may represent a copious source of Higgs bosons through cascade decays. The ...

  14. Application of proteomics in biomarker discovery: a primer for the clinician.

    Science.gov (United States)

    Tambor, V; Fucíková, A; Lenco, J; Kacerovský, M; Rehácek, V; Stulík, J; Pudil, R

    2010-01-01

    Ever since proteomics was proven to be capable of characterizing a large number of differences in both protein quality and quantity, it has been applied in various areas of biomedicine, ranging from the deciphering molecular pathogenesis of diseases to the characterization of novel drug targets and the discovery of potential diagnostic biomarkers. Indeed, the biomarker discovery in human plasma is clearly one of the areas with enormous potential. However, without proper planning and implementation of specific techniques, the efforts and expectations may very easily be hampered. Numerous earlier projects aimed at clinical proteomics, characterized by exaggerated enthusiasm, often underestimated some principal obstacles of plasma biomarker discovery. Consequently, ambiguous and insignificant results soon led to a more critical view in this field. In this article, we critically review the current state of proteomic approaches for biomarker discovery and validation, in order to provide basic information and guidelines for both clinicians and researchers. These need to be closely considered prior to initiation of a project aimed at plasma biomarker discovery. We also present a short overview of recent applications of clinical proteomics in biomarker discovery.

  15. An Overview of Catalog Design Problems in Resource Discovery.

    Science.gov (United States)

    Goodchild, Andrew

    1996-01-01

    Many catalogs are built in an ad hoc fashion, which results in uncertain quality in publicly accessible network catalogs. This article discusses problems facing designers building catalogs for large networks, relating them to resource discovery; provides a usability framework based on library science and human computer interaction literature; and…

  16. The discovery of plutonium reorganized the periodic table and aided the discovery of new elements

    International Nuclear Information System (INIS)

    Clark, David L.

    2009-01-01

    they named neptunium after the planet Neptune. This rapidly set the stage for the discovery of the next succeeding element, plutonium (Seaborg, McMillan, Kennedy, and Wahl, 1940), named after the next planet away from the Sun, Pluto. The newly discovered elements were presumed to fit comfortably in the Periodic Table under rhenium and osmium, respectively. However, subsequent tracer chemical experiments showed that neptunium and plutonium were closer in their chemical properties to uranium than their presumed homologues, rhenium and osmium. Spectroscopic evidence also indicated that the new elements were not typical transition elements, but had f-electrons in their valence shell. Thus, several researchers, including McMillan and Wahl, and Zachariasen at Los Alamos, suggested that these elements might be part of a second inner-transition series in which the 5f-electron subshell was being filled. It was not clear, however, where the new series would begin. McMillian had proposed a 'uraninide series' that started with neptunium, but attempts to isolate elements with atomic numbers 95 and 96 based on assumed similarities to uranium were unsuccessful. Both Wahl and Zacharias en had proposed a thoride series that started with protactinium. In 1944, Seaborg proposed that the series started with thorium, and that all of the elements heavier than actinium constituted an 'actinide' series similar to the lanthanides. Because the 5f-shell began filling in the same relative position as the 4f-shell, the electronic configuration of elements in the two series would be similar. Guided by the hypothesis that elements 95 and 96 were homologues of europium and gadolinium, new experiments were designed and the elements were uniquely synthesized and separated from all others. The new elements were subsequently named americium and curium. Seaborg's 'Actinide Concept' thus played a major role in the discovery of the transplutonium elements. It provided the framework that supported synthesis

  17. SECURE SERVICE DISCOVERY BASED ON PROBE PACKET MECHANISM FOR MANETS

    Directory of Open Access Journals (Sweden)

    S. Pariselvam

    2015-03-01

    Full Text Available In MANETs, Service discovery process is always considered to be crucial since they do not possess a centralized infrastructure for communication. Moreover, different services available through the network necessitate varying categories. Hence, a need arises for devising a secure probe based service discovery mechanism to reduce the complexity in providing the services to the network users. In this paper, we propose a Secure Service Discovery Based on Probe Packet Mechanism (SSDPPM for identifying the DoS attack in MANETs, which depicts a new approach for estimating the level of trust present in each and every routing path of a mobile ad hoc network by using probe packets. Probing based service discovery mechanisms mainly identifies a mobile node’s genuineness using a test packet called probe that travels the entire network for the sake of computing the degree of trust maintained between the mobile nodes and it’s attributed impact towards the network performance. The performance of SSDPPM is investigated through a wide range of network related parameters like packet delivery, throughput, Control overhead and total overhead using the version ns-2.26 network simulator. This mechanism SSDPPM, improves the performance of the network in an average by 23% and 19% in terms of packet delivery ratio and throughput than the existing service discovery mechanisms available in the literature.

  18. Common Ground: An Interactive Visual Exploration and Discovery for Complex Health Data

    Science.gov (United States)

    2015-12-01

    analyst from the Utah State Health Department’s Bureau of Epidemiology and Communicable Diseases and the Salt Lake County Health Department • Two...Award Number: W81XWH-13-1-0028 TITLE: Common Ground: An Interactive Visual Exploration and Discovery for Complex Health Data PRINCIPAL...INVESTIGATOR: Yarden Livnat CONTRACTING ORGANIZATION: University of Utah Salt Lake City, UT 84112 REPORT DATE: December 2015 TYPE OF REPORT: Final

  19. Polar Domain Discovery with Sparkler

    Science.gov (United States)

    Duerr, R.; Khalsa, S. J. S.; Mattmann, C. A.; Ottilingam, N. K.; Singh, K.; Lopez, L. A.

    2017-12-01

    The scientific web is vast and ever growing. It encompasses millions of textual, scientific and multimedia documents describing research in a multitude of scientific streams. Most of these documents are hidden behind forms which require user action to retrieve and thus can't be directly accessed by content crawlers. These documents are hosted on web servers across the world, most often on outdated hardware and network infrastructure. Hence it is difficult and time-consuming to aggregate documents from the scientific web, especially those relevant to a specific domain. Thus generating meaningful domain-specific insights is currently difficult. We present an automated discovery system (Figure 1) using Sparkler, an open-source, extensible, horizontally scalable crawler which facilitates high throughput and focused crawling of documents pertinent to a particular domain such as information about polar regions. With this set of highly domain relevant documents, we show that it is possible to answer analytical questions about that domain. Our domain discovery algorithm leverages prior domain knowledge to reach out to commercial/scientific search engines to generate seed URLs. Subject matter experts then annotate these seed URLs manually on a scale from highly relevant to irrelevant. We leverage this annotated dataset to train a machine learning model which predicts the `domain relevance' of a given document. We extend Sparkler with this model to focus crawling on documents relevant to that domain. Sparkler avoids disruption of service by 1) partitioning URLs by hostname such that every node gets a different host to crawl and by 2) inserting delays between subsequent requests. With an NSF-funded supercomputer Wrangler, we scaled our domain discovery pipeline to crawl about 200k polar specific documents from the scientific web, within a day.

  20. DISCOVERY OF A MAKEMAKEAN MOON

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Alex H.; Buie, Marc W. [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States); Grundy, Will M. [Lowell Observatory, Flagstaff, AZ (United States); Noll, Keith S., E-mail: aparker@boulder.swri.edu [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2016-07-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope ’s Wide Field Camera 3 on UTC 2015 April 27 at 7.80 ± 0.04 mag fainter than Makemake and at a separation of 0.″57. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days and must have a semimajor axis ≳21,000 km. We find that the properties of Makemake’s moon suggest that the majority of the dark material detected in the system by thermal observations may not reside on the surface of Makemake, but may instead be attributable to S/2015 (136472) 1 having a uniform dark surface. This “dark moon hypothesis” can be directly tested with future James Webb Space Telescope observations. We discuss the implications of this discovery for the spin state, figure, and thermal properties of Makemake and the apparent ubiquity of trans-Neptunian dwarf planet satellites.

  1. Does Superintendents' Leadership Styles Influence Principals' Performance?

    Science.gov (United States)

    Davis, Theresa D.

    2014-01-01

    Educational leaders across the United States face changes affecting the educational system related to federal and state mandates. The stress of those changes may be related to superintendents' longevity. The superintendent position has a mobility rate that is quite high. Every superintendent is different and may have a different leadership style…

  2. The scientist as philosopher philosophical consequences of great scientific discoveries

    CERN Document Server

    Weinert, Friedel

    2005-01-01

    How do major scientific discoveries reshape their originators’, and our own, sense of reality and concept of the physical world? The Scientist as Philosopher explores the interaction between physics and philosophy. Clearly written and well illustrated, the book first places the scientist-philosophers in the limelight as we learn how their great scientific discoveries forced them to reconsider the time-honored notions with which science had described the natural world. Then, the book explains that what we understand by nature and science have undergone fundamental conceptual changes as a result of the discoveries of electromagnetism, thermodynamics and atomic structure. Even more dramatically, the quantum theory and special theory of relativity questioned traditional assumptions about causation and the passage of time. The author concludes that the dance between science and philosophy is an evolutionary process, which will keep them forever entwined.

  3. New vaccines: challenges of discovery.

    Science.gov (United States)

    Mahmoud, Adel

    2016-09-01

    Vaccines have been a major component of preventing and controlling infectious diseases. The basis for discovery of what protects is reviewed as well as new attempts in utilizing Reverse Vaccinology, RNA-RNA methods and proteome analysis are adding significantly to our knowledge. The challenge of how to define protective and defined components of microbes is still hampering efforts to discover new vaccines. Recent excitement about immunotherapy of cancer opens the way to develop vaccines against multiple malignancies. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

  4. Scientific discovery using genetic programming

    DEFF Research Database (Denmark)

    Keijzer, Maarten

    2001-01-01

    in this work can be summarized as: The symbolic expressions produced by genetic programming can be made suitable for analysis and interpretation by using units of measurements to guide or restrict the search. To achieve this, the following has been accomplished: A standard genetic programming system...... that are numerically stable and correct. A case study using four real-world problems in the induction of dimensionally correct empirical equations on data using the two different methods is presented to illustrate to use and limitations of these methods in a framework of scientific discovery....

  5. Relativity

    CERN Document Server

    Einstein, Albert

    2013-01-01

    Time magazine's ""Man of the Century"", Albert Einstein is the founder of modern physics and his theory of relativity is the most important scientific idea of the modern era. In this short book, Einstein explains, using the minimum of mathematical terms, the basic ideas and principles of the theory that has shaped the world we live in today. Unsurpassed by any subsequent books on relativity, this remains the most popular and useful exposition of Einstein's immense contribution to human knowledge.With a new foreword by Derek Raine.

  6. Hurwitz stability analysis of fractional order LTI systems according to principal characteristic equations.

    Science.gov (United States)

    Alagoz, Baris Baykant

    2017-09-01

    With power mapping (conformal mapping), stability analyses of fractional order linear time invariant (LTI) systems are carried out by consideration of the root locus of expanded degree integer order polynomials in the principal Riemann sheet. However, it is essential to show the left half plane (LHP) stability analysis of fractional order characteristic polynomials in the s plane in order to close the gap emerging in stability analyses of fractional order and integer order systems. In this study, after briefly discussing the relation between the characteristic root orientations and the system stability, the author presents a methodology to establish principal characteristic polynomials to perform the LHP stability analysis of fractional order systems. The principal characteristic polynomials are formed by factorizing principal characteristic roots. Then, the LHP stability analysis of fractional order systems can be carried out by using the root equivalency of fractional order principal characteristic polynomials. Illustrative examples are presented to explain how to find equivalent roots of fractional order principal characteristic polynomials in order to carry out the LHP stability analyses of fractional order nominal and interval systems. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Mapping ash properties using principal components analysis

    Science.gov (United States)

    Pereira, Paulo; Brevik, Eric; Cerda, Artemi; Ubeda, Xavier; Novara, Agata; Francos, Marcos; Rodrigo-Comino, Jesus; Bogunovic, Igor; Khaledian, Yones

    2017-04-01

    In post-fire environments ash has important benefits for soils, such as protection and source of nutrients, crucial for vegetation recuperation (Jordan et al., 2016; Pereira et al., 2015a; 2016a,b). The thickness and distribution of ash are fundamental aspects for soil protection (Cerdà and Doerr, 2008; Pereira et al., 2015b) and the severity at which was produced is important for the type and amount of elements that is released in soil solution (Bodi et al., 2014). Ash is very mobile material, and it is important were it will be deposited. Until the first rainfalls are is very mobile. After it, bind in the soil surface and is harder to erode. Mapping ash properties in the immediate period after fire is complex, since it is constantly moving (Pereira et al., 2015b). However, is an important task, since according the amount and type of ash produced we can identify the degree of soil protection and the nutrients that will be dissolved. The objective of this work is to apply to map ash properties (CaCO3, pH, and select extractable elements) using a principal component analysis (PCA) in the immediate period after the fire. Four days after the fire we established a grid in a 9x27 m area and took ash samples every 3 meters for a total of 40 sampling points (Pereira et al., 2017). The PCA identified 5 different factors. Factor 1 identified high loadings in electrical conductivity, calcium, and magnesium and negative with aluminum and iron, while Factor 3 had high positive loadings in total phosphorous and silica. Factor 3 showed high positive loadings in sodium and potassium, factor 4 high negative loadings in CaCO3 and pH, and factor 5 high loadings in sodium and potassium. The experimental variograms of the extracted factors showed that the Gaussian model was the most precise to model factor 1, the linear to model factor 2 and the wave hole effect to model factor 3, 4 and 5. The maps produced confirm the patternd observed in the experimental variograms. Factor 1 and 2

  8. Principal spectra describing magnetooptic permittivity tensor in cubic crystals

    Energy Technology Data Exchange (ETDEWEB)

    Hamrlová, Jana [Nanotechnology Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Legut, Dominik [IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Veis, Martin [Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, Prague, 121 16 Czech Republic (Czech Republic); Pištora, Jaromír [Nanotechnology Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Hamrle, Jaroslav, E-mail: jaroslav.hamrle@vsb.cz [IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, Prague, 121 16 Czech Republic (Czech Republic); Department of Physics, VSB – Technical University of Ostrava, 17. listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic)

    2016-12-15

    We provide unified phenomenological description of magnetooptic effects being linear and quadratic in magnetization. The description is based on few principal spectra, describing elements of permittivity tensor up to the second order in magnetization. Each permittivity tensor element for any magnetization direction and any sample surface orientation is simply determined by weighted summation of the principal spectra, where weights are given by crystallographic and magnetization orientations. The number of principal spectra depends on the symmetry of the crystal. In cubic crystals owning point symmetry we need only four principal spectra. Here, the principal spectra are expressed by ab initio calculations for bcc Fe, fcc Co and fcc Ni in optical range as well as in hard and soft x-ray energy range, i.e. at the 2p- and 3p-edges. We also express principal spectra analytically using modified Kubo formula.

  9. Preliminary Test Estimation for Multi-Sample Principal Components

    OpenAIRE

    Paindaveine, Davy; Rasoafaraniaina, Rondrotiana J; Verdebout, Thomas

    2016-01-01

    In this paper, we consider point estimation in a multi-sample principal components setup, in a situation where it is suspected that the hypothesis of common principal components (CPC) holds. We propose preliminary test estimators of the various principal eigenvectors. We derive their asymptotic distributions (i) under the CPC hypothesis, (ii) under sequences of hypotheses that are contiguous to the CPC hypothesis, and (iii) away from the CPC hypothesis. We conduct a Monte-Carlo study that sho...

  10. Computing Cumulative Interest and Principal Paid For a Calendar Year

    OpenAIRE

    John O. MASON

    2011-01-01

    This paper demonstrates how easy it is use Microsoft Excel’s CUMPRINC and CUMIPMT functions to compute principal and interest paid for an entire year, even though the payments were made monthly. The CUMPRINC function computes the principal paid by a series of loan payments; the CUMIPMT function computes the interest paid. These two functions provide an alternative to preparing a monthly loan amortization schedule and adding up the amounts of monthly interest paid and principal paid for the ye...

  11. The Discovery of Artificial Radioactivity

    Science.gov (United States)

    Guerra, Francesco; Leone, Matteo; Robotti, Nadia

    2012-03-01

    We reconstruct Frédéric Joliot and Irène Curie's discovery of artificial radioactivity in January 1934 based in part on documents preserved in the Joliot-Curie Archives in Paris, France. We argue that their discovery followed from the convergence of two parallel lines of research, on the neutron and on the positron, that were focused on a well-defined experimental problem, the nuclear transmutation of aluminum and other light elements. We suggest that a key role was played by a suggestion that Francis Perrin made at the seventh Solvay Conference at the end of October 1933, that the alpha-particle bombardment of aluminum produces an intermediate unstable isotope of phosphorus, which then decays by positron emission. We also suggest that a further idea that Perrin published in December 1933, and the pioneering theory of beta decay that Enrico Fermi also first published in December 1933, established a new theoretical framework that stimulated Joliot to resume the researches that he and Curie had interrupted after the Solvay Conference, now for the first time using a Geiger-Müller counter to detect the positrons emitted when he bombarded aluminum with polonium alpha particles.

  12. Quasi-Periodic Crystals—The Long Road from Discovery to Acceptance

    Directory of Open Access Journals (Sweden)

    Daniel Schechtman

    2013-01-01

    Full Text Available [Extract] Three surprising discoveries on the nature of matter and its properties were published in the mid-1980s. All these discoveries led to Nobel prizes. The first discovery was in 1985, when fullerenes were discovered by Robert F. Curl Jr, Sir Harold W. Kroto, and Richard E. Smalley. Fullerenes, also known as buckyballs, are spherical molecules composed of carbon atoms. The discovery of fullerenes launched the field of nano-materials, one of the fastest-growing fields in chemistry today. In 1996, 11 years after the publication of the discovery, the three researchers were jointly awarded the Nobel Prize in chemistry. No controversy surrounded this discovery. In 1986, two IBM researchers, Karl Müller and Johannes Bednorz, discovered high-temperature superconductive materials. Although superconductivity was first discovered in 1911, nobody expected to see this phenomenon at the relatively high temperatures of liquid nitrogen. In 1987, one year after publishing their discovery, the two researchers were awarded the Nobel Prize in physics. Again, no controversy surrounded this discovery, and, as the short period of time between the discovery and awarding of the prize shows, the discovery was enthusiastically embraced by the scientific community. Publication of the third discovery pre-dates the publication of the other two discoveries. I published the discovery of quasi-periodic crystals in 1984 and was awarded a Nobel Prize in 2011, 27 years after the discovery. Unlike the previous two discoveries, this discovery was met with fierce opposition and a substantial amount of controversy. What was so controversial about this discovery that it raised the antagonism of so many people in the scientific community? Why would Linus Pauling, a twice-awarded Nobel Laureate and one of the greatest chemists of the twentieth century, state: “There is no such thing as quasi-crystals, only quasi-scientists”? In order to answer these questions, I must first

  13. Solar Water Splitting: Photocatalyst Materials Discovery and Systems Development

    Energy Technology Data Exchange (ETDEWEB)

    McNulty, Thomas F.

    2008-05-02

    Hydrogen promises to be an attractive transportation fuel in the post-fossil fuel era. Relatively abundant and clean burning (water being the principal byproduct), hydrogen offers the potential to significantly reduce greenhouse gas emissions. However, there are significant technical barriers that require solutions before hydrogen can be implemented in large scale. These are: · Sources (e.g. hydrocarbon, water) · Transportation · Storage Each of the aforementioned barriers carries with it important considerations. First, would a hydrocarbon-based hydrogen source be of any benefit compared to conventional fossil fuels? Second, will a system based on centralized generation and distribution be viable? Finally, methods of on-board storage, whether they are liquefaction, adsorption, or intercalation, are far from optimized. The scope of this program is limited to hydrogen generation, specifically generation using solarinitiated water electrolysis. Though concept of making hydrogen using water and sunlight may sound somewhat far-fetched, in reality the concept is very real. Since the discovery of solar-generated hydrogen, termed photoelectrochemical hydrogen, nearly 30 years ago by Fujishima and Honda, significant advances in both fundamental understanding and technological capability have been made. Using solar radiation to generate hydrogen in a fashion akin to using solar to generate electricity offers many advantages. First, hydrogen can be generated at the point of use, reducing the importance of transportation. Second, using water as the hydrogen source eliminates greenhouse gas evolution and the consequences that come with it. Finally, because the process uses very little electricity (pumps and compressors predominantly), the quantity of chemical fuel produced far exceeds the amount of electricity consumed. Consequently, there is some level of truth to the notion that photoelectrochemically-derived hydrogen offers the potential to nearly eliminate greenhouse

  14. Incremental Tensor Principal Component Analysis for Handwritten Digit Recognition

    Directory of Open Access Journals (Sweden)

    Chang Liu

    2014-01-01

    Full Text Available To overcome the shortcomings of traditional dimensionality reduction algorithms, incremental tensor principal component analysis (ITPCA based on updated-SVD technique algorithm is proposed in this paper. This paper proves the relationship between PCA, 2DPCA, MPCA, and the graph embedding framework theoretically and derives the incremental learning procedure to add single sample and multiple samples in detail. The experiments on handwritten digit recognition have demonstrated that ITPCA has achieved better recognition performance than that of vector-based principal component analysis (PCA, incremental principal component analysis (IPCA, and multilinear principal component analysis (MPCA algorithms. At the same time, ITPCA also has lower time and space complexity.

  15. Genetic Diversity of Mycobacterium tuberculosis Isolates from Assam, India: Dominance of Beijing Family and Discovery of Two New Clades Related to CAS1_Delhi and EAI Family Based on Spoligotyping and MIRU-VNTR Typing.

    Science.gov (United States)

    Devi, Kangjam Rekha; Bhutia, Rinchenla; Bhowmick, Shovonlal; Mukherjee, Kaustab; Mahanta, Jagadish; Narain, Kanwar

    2015-01-01

    isolates from Assam represent two new sub-clades Assam/EAI and Assam/CAS. The prevalence of multidrug resistance (MDR) in Beijing and Non-Beijing strains was found to be 10.44% and 9.01% respectively. In conclusion, the present study has shown the predominance of Beijing isolates in Assam which is a matter of great concern because Beijing strains are considered to be ecologically more fit enabling wider dissemination of M. tuberculosis. Other interesting finding of the present study is the discovery of two new clades of MTBC isolates circulating in Assam. More elaborate longitudinal studies are required to be undertaken in this region to understand the transmission dynamics of MTBC.

  16. Estudo da ocorrência de fluxos no perfil vertical do vento na baixa atmosfera com análise das componentes principais (ACP e a sua relação com a precipitação no Rio Grande do Sul Vertical wind profile uses a principal component analysis, and of their relation to precipitation in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Cleber Souza Corrêa

    2007-04-01

    nocturnal convective events and with the generation of Mesoscale Convective Complexes (MCCs, giving high rainfall intensities, which may have important economic consequences. To describe the relations involved, the study uses a statistical method principal component analysis. Use of this method makes it possible to understand the complex interactions operating at meteorological scales involved in synoptic processes, from macro- to meso-scale. In such complexity, the part played by LLJs and Flows in this interaction is to effect transport in the lower atmosphere, thereby coupling regional meteorology and water circulation at the continental scale.

  17. Principal Component Analysis of Terrestrial and Venusian Topography

    Science.gov (United States)

    Stoddard, P. R.; Jurdy, D. M.

    2015-12-01

    We use Principal Component Analysis (PCA) as an objective tool in analyzing, comparing, and contrasting topographic profiles of different/similar features from different locations and planets. To do so, we take average profiles of a set of features and form a cross-correlation matrix, which is then diagonalized to determine its principal components. These components, not merely numbers, represent actual profile shapes that give a quantitative basis for comparing different sets of features. For example, PCA for terrestrial hotspots shows the main component as a generic dome shape. Secondary components show a more sinusoidal shape, related to the lithospheric loading response, and thus give information about the nature of the lithosphere setting of the various hotspots. We examine a range of terrestrial spreading centers: fast, slow, ultra-slow, incipient, and extinct, and compare these to several chasmata on Venus (including Devana, Ganis, Juno, Parga, and Kuanja). For upwelling regions, we consider the oceanic Hawaii, Reunion, and Iceland hotspots and Yellowstone, a prototypical continental hotspot. Venus has approximately one dozen broad topographic and geoid highs called regiones. Our analysis includes Atla, Beta, and W. Eistla regiones. Atla and Beta are widely thought to be the most likely to be currently or recently active. Analysis of terrestrial rifts suggests shows increasing uniformity of shape among rifts with increasing spreading rates. Venus' correlations of uniformity rank considerably lower than the terrestrial ones. Extrapolating the correlation/spreading rate suggests that Venus' chasmata, if analogous to terrestrial spreading centers, most resemble the ultra-slow spreading level (less than 12mm/yr) of the Arctic Gakkel ridge. PCA will provide an objective measurement of this correlation.

  18. Principal semantic components of language and the measurement of meaning.

    Science.gov (United States)

    Samsonovich, Alexei V; Samsonovic, Alexei V; Ascoli, Giorgio A

    2010-06-11

    Metric systems for semantics, or semantic cognitive maps, are allocations of words or other representations in a metric space based on their meaning. Existing methods for semantic mapping, such as Latent Semantic Analysis and Latent Dirichlet Allocation, are based on paradigms involving dissimilarity metrics. They typically do not take into account relations of antonymy and yield a large number of domain-specific semantic dimensions. Here, using a novel self-organization approach, we construct a low-dimensional, context-independent semantic map of natural language that represents simultaneously synonymy and antonymy. Emergent semantics of the map principal components are clearly identifiable: the first three correspond to the meanings of "good/bad" (valence), "calm/excited" (arousal), and "open/closed" (freedom), respectively. The semantic map is sufficiently robust to allow the automated extraction of synonyms and antonyms not originally in the dictionaries used to construct the map and to predict connotation from their coordinates. The map geometric characteristics include a limited number ( approximately 4) of statistically significant dimensions, a bimodal distribution of the first component, increasing kurtosis of subsequent (unimodal) components, and a U-shaped maximum-spread planar projection. Both the semantic content and the main geometric features of the map are consistent between dictionaries (Microsoft Word and Princeton's WordNet), among Western languages (English, French, German, and Spanish), and with previously established psychometric measures. By defining the semantics of its dimensions, the constructed map provides a foundational metric system for the quantitative analysis of word meaning. Language can be viewed as a cumulative product of human experiences. Therefore, the extracted principal semantic dimensions may be useful to characterize the general semantic dimensions of the content of mental states. This is a fundamental step toward a

  19. Principal semantic components of language and the measurement of meaning.

    Directory of Open Access Journals (Sweden)

    Alexei V Samsonovich

    Full Text Available Metric systems for semantics, or semantic cognitive maps, are allocations of words or other representations in a metric space based on their meaning. Existing methods for semantic mapping, such as Latent Semantic Analysis and Latent Dirichlet Allocation, are based on paradigms involving dissimilarity metrics. They typically do not take into account relations of antonymy and yield a large number of domain-specific semantic dimensions. Here, using a novel self-organization approach, we construct a low-dimensional, context-independent semantic map of natural language that represents simultaneously synonymy and antonymy. Emergent semantics of the map principal components are clearly identifiable: the first three correspond to the meanings of "good/bad" (valence, "calm/excited" (arousal, and "open/closed" (freedom, respectively. The semantic map is sufficiently robust to allow the automated extraction of synonyms and antonyms not originally in the dictionaries used to construct the map and to predict connotation from their coordinates. The map geometric characteristics include a limited number ( approximately 4 of statistically significant dimensions, a bimodal distribution of the first component, increasing kurtosis of subsequent (unimodal components, and a U-shaped maximum-spread planar projection. Both the semantic content and the main geometric features of the map are consistent between dictionaries (Microsoft Word and Princeton's WordNet, among Western languages (English, French, German, and Spanish, and with previously established psychometric measures. By defining the semantics of its dimensions, the constructed map provides a foundational metric system for the quantitative analysis of word meaning. Language can be viewed as a cumulative product of human experiences. Therefore, the extracted principal semantic dimensions may be useful to characterize the general semantic dimensions of the content of mental states. This is a fundamental step

  20. Principal component analysis of FDG PET in amnestic MCI

    International Nuclear Information System (INIS)

    Nobili, Flavio; Girtler, Nicola; Brugnolo, Andrea; Dessi, Barbara; Rodriguez, Guido; Salmaso, Dario; Morbelli, Silvia; Piccardo, Arnoldo; Larsson, Stig A.; Pagani, Marco

    2008-01-01

    The purpose of the study is to evaluate the combined accuracy of episodic memory performance and 18 F-FDG PET in identifying patients with amnestic mild cognitive impairment (aMCI) converting to Alzheimer's disease (AD), aMCI non-converters, and controls. Thirty-three patients with aMCI and 15 controls (CTR) were followed up for a mean of 21 months. Eleven patients developed AD (MCI/AD) and 22 remained with aMCI (MCI/MCI). 18 F-FDG PET volumetric regions of interest underwent principal component analysis (PCA) that identified 12 principal components (PC), expressed by coarse component scores (CCS). Discriminant analysis was performed using the significant PCs and episodic memory scores. PCA highlighted relative hypometabolism in PC5, including bilateral posterior cingulate and left temporal pole, and in PC7, including the bilateral orbitofrontal cortex, both in MCI/MCI and MCI/AD vs CTR. PC5 itself plus PC12, including the left lateral frontal cortex (LFC: BAs 44, 45, 46, 47), were significantly different between MCI/AD and MCI/MCI. By a three-group discriminant analysis, CTR were more accurately identified by PET-CCS + delayed recall score (100%), MCI/MCI by PET-CCS + either immediate or delayed recall scores (91%), while MCI/AD was identified by PET-CCS alone (82%). PET increased by 25% the correct allocations achieved by memory scores, while memory scores increased by 15% the correct allocations achieved by PET. Combining memory performance and 18 F-FDG PET yielded a higher accuracy than each single tool in identifying CTR and MCI/MCI. The PC containing bilateral posterior cingulate and left temporal pole was the hallmark of MCI/MCI patients, while the PC including the left LFC was the hallmark of conversion to AD. (orig.)

  1. Usability Test Results for a Discovery Tool in an Academic Library

    Directory of Open Access Journals (Sweden)

    Jody Condit Fagan

    2008-03-01

    Full Text Available Discovery tools are emerging in libraries. These tools offer library patrons the ability to concurrently search the library catalog and journal articles. While vendors rush to provide feature-rich interfaces and access to as much content as possible, librarians wonder about the usefulness of these tools to library patrons. In order to learn about both the utility and usability of EBSCO Discovery Service, James Madison University conducted a usability test with eight students and two faculty members. The test consisted of nine tasks focused on common patron requests or related to the utility of specific discovery tool features. Software recorded participants’ actions and time on task, human observers judged the success of each task, and a post-survey questionnaire gathered qualitative feedback and comments from the participants.  Overall, participants were successful at most tasks, but specific usability problems suggested some interface changes for both EBSCO Discovery Service and JMU’s customizations of the tool.  The study also raised several questions for libraries above and beyond any specific discovery tool interface, including the scope and purpose of a discovery tool versus other library systems, working with the large result sets made possible by discovery tools, and navigation between the tool and other library services and resources.  This article will be of interest to those who are investigating discovery tools, selecting products, integrating discovery tools into a library web presence, or performing evaluations of similar systems.

  2. PRINCIPAL COMPONENT ANALYSIS TO EVALUATE THE SPATIAL ...

    African Journals Online (AJOL)

    B. S. Chandravanshi

    gauging kaolin variations across samples and in validating new predictive modeling applications. Successful applications will depend on how clay and data scientists keep track, synchronise and share information relating to potentially dynamic data such as the impact of discretisation of kaolin particle sizes. KEY WORDS: ...

  3. 29 CFR 780.1010 - Principally.

    Science.gov (United States)

    2010-07-01

    ... Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR... in Making Wreaths; Exemption From Minimum Wage, Overtime Compensation, and Child Labor Provisions... apply to the making of an evergreen wreath. Such a wreath is one made “principally” of evergreens...

  4. The discovery of a conjugate system of faults in the Wharton Basin intraplate deformation zone.

    Science.gov (United States)

    Singh, Satish C; Hananto, Nugroho; Qin, Yanfang; Leclerc, Frederique; Avianto, Praditya; Tapponnier, Paul E; Carton, Helene; Wei, Shengji; Nugroho, Adam B; Gemilang, Wishnu A; Sieh, Kerry; Barbot, Sylvain

    2017-01-01

    The deformation at well-defined, narrow plate boundaries depends on the relative plate motion, but how the deformation takes place within a distributed plate boundary zone remains a conundrum. This was confirmed by the seismological analyses of the 2012 great Wharton Basin earthquakes [moment magnitude ( M w ) 8.6], which suggested the rupture of several faults at high angles to one another. Using high-resolution bathymetry and seismic reflection data, we report the discovery of new N294°E-striking shear zones, oblique to the plate fabric. These shear zones are expressed by sets of normal faults striking at N335°E, defining the direction of the principal compressional stress in the region. Also, we have imaged left-lateral strike-slip faults along reactivated N7°E-oriented oceanic fracture zones. The shear zones and the reactivated fracture zones form a conjugate system of faults, which accommodate present-day intraplate deformation in the Wharton Basin.

  5. mHealth Visual Discovery Dashboard.

    Science.gov (United States)

    Fang, Dezhi; Hohman, Fred; Polack, Peter; Sarker, Hillol; Kahng, Minsuk; Sharmin, Moushumi; al'Absi, Mustafa; Chau, Duen Horng

    2017-09-01

    We present Discovery Dashboard, a visual analytics system for exploring large volumes of time series data from mobile medical field studies. Discovery Dashboard offers interactive exploration tools and a data mining motif discovery algorithm to help researchers formulate hypotheses, discover trends and patterns, and ultimately gain a deeper understanding of their data. Discovery Dashboard emphasizes user freedom and flexibility during the data exploration process and enables researchers to do things previously challenging or impossible to do - in the web-browser and in real time. We demonstrate our system visualizing data from a mobile sensor study conducted at the University of Minnesota that included 52 participants who were trying to quit smoking.

  6. Recent discoveries of anticancer flavonoids.

    Science.gov (United States)

    Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Plescia, Fabiana; Daidone, Giuseppe

    2017-12-15

    In this review we report the recent advances in anticancer activity of the family of natural occurring flavonoids, covering the time span of the last five years. The bibliographic data will be grouped, on the basis of biological information, in two great categories: reports in which the extract plants bioactivity is reported and the identification of each flavonoid is present or not, and reports in which the anticancer activity is attributable to purified and identified flavonoids from plants. Wherever possible, the targets and mechanisms of action as well as the structure-activity relationships of the molecules will be reported. Also, in the review it was thoroughly investigated the recent discovery on flavonoids containing the 2-phenyl-4H-chromen-4-one system even if some examples of unusual flavonoids, bearing a non-aromatic B-ring or other ring condensed to the base structure are reported. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  7. Transgenic parasites accelerate drug discovery

    Science.gov (United States)

    Rodriguez, Ana; Tarleton, Rick L.

    2013-01-01

    Parasitic neglected diseases are in dire need of new drugs either to replace old drugs rendered ineffective because of resistance development, to cover clinical needs that had never been addressed or to tackle other associated problems of existing drugs such as high cost, difficult administration, restricted coverage or toxicity. The availability of transgenic parasites expressing reporter genes facilitates the discovery of new drugs through high throughput screenings, but also by allowing rapid screening in animal models of disease. Taking advantage of these, we propose an alternative pathway of drug development for neglected diseases, going from high throughput screening directly into in vivo testing of the top ranked compounds selected by medicinal chemistry. Rapid assessment animal models allow for identification of compounds with bona fide activity in vivo early in the development chain, constituting a solid basis for further development and saving valuable time and resources. PMID:22277131

  8. Preschool Principal's Curriculum Leadership Indicators: A Taiwan Perspective

    Science.gov (United States)

    Lin, Chia-Fen; Lee, John Chi-Kin

    2013-01-01

    The role of a principal's curriculum leadership has become an educational issue in Taiwan's early childhood education. This study represents a pioneering attempt in adopting a target school interview, fuzzy Delphi, and analytic hierarchy process for constructing preschool principal's curriculum leadership indicators. Fifteen experts and…

  9. Invisible Barriers: The Loneliness of School Principals at Turkish ...

    African Journals Online (AJOL)

    Psychological insight is the notion that all participants agreed on and emphasised when asked to offer a definition of loneliness at schools. Participants also agreed on the fact that the organisational climate at Turkish schools represented the most significant reason for principals' loneliness at work. The school principals that ...

  10. Principals' and Teachers' Attitudes towards Inclusion in Israel

    Science.gov (United States)

    Hess, Itay; Zamir, Sara

    2016-01-01

    The main goal of this study was to determine whether, in schools that practice inclusion, there is a correlation between the attitudes of school principals and teachers in their schools, towards inclusion of student with special needs. For this purpose, 38 schools were sampled in each of which the school principal and five teachers who work with…

  11. Identifying and Addressing Themes of Job Dissatisfaction for Secondary Principals

    Science.gov (United States)

    De Jong, David; Grundmeyer, Trent; Yankey, Julie

    2017-01-01

    Secondary principals serve in important roles that are complex, high-stress, and include demanding job responsibilities. Key stakeholders such as superintendents, school board members, and legislators must understand the challenges facing secondary principals in order to address the current themes of job dissatisfaction. Using new survey data…

  12. A Review of Singapore Principals' Leadership Qualities, Styles, and Roles

    Science.gov (United States)

    Ng, David Foo Seong; Nguyen, Dong Thanh; Wong, Benjamin Koon Siak; Choy, William Kim Weng

    2015-01-01

    Purpose: The purpose of this paper is to present a review of empirical studies on principal leadership in Singapore. It seeks to provide a general picture of Singapore principals' leadership qualities, styles, and roles. Design/methodology/approach: This is a systematic review of empirical studies, using a "bounded" approach with a focus…

  13. The Relationship of Principal Conflict Management Style and School Climate

    Science.gov (United States)

    Boucher, Miriam Miley

    2013-01-01

    Using a mixed-methods design, this study examined conflict management styles of elementary school principals in South Carolina and the relationship of conflict management style and school climate. The Rahim Organizational Conflict Inventory-II, Form B, which identifies five styles of managing conflict, was used to determine principal conflict…

  14. Principal Component Analysis: Most Favourite Tool in Chemometrics

    Indian Academy of Sciences (India)

    Data compression by. PCA involves finding a new space spanned by fewer number of dimensions over which original data set is projected. The dimensions of the ... The variable that ex- plains the maximum variation is called the first principal compo- nent. Second principal component explains the second highest variation ...

  15. Principal Preparation Matters: How Leadership Development Affects Student Achievement. Brief

    Science.gov (United States)

    Gates, Susan M.; Hamilton, Laura S.; Martorell, Paco; Burkhauser, Susan; Heaton, Paul; Pierson, Ashley; Baird, Matthew D.; Vuollo, Mirka; Li, Jennifer J.; Lavery, Diana; Harvey, Melody; Gu, Kun

    2014-01-01

    In 2006, New Leaders contracted with RAND to conduct an independent evaluation of its principal-preparation program. The analysis included all principals who have been prepared by New Leaders since the inception of the program, comparing outcomes of their students and outcomes of similar students in other, comparable schools in the same districts.…

  16. Location and characterisation of pollution sites by principal ...

    African Journals Online (AJOL)

    Location and characterisation of pollution sites by principal component analysis of trace contaminants in a slightly polluted seasonal river: a case study of the Arenales River (Salta, Argentina) ... Keywords: trace element contamination, water quality, principal component analysis, Arenales River, Salta, Argentina ...

  17. Principals' Perception of Educational Inputs and Students' Academic ...

    African Journals Online (AJOL)

    This study investigated principals' perception of the relationship between educational inputs and academic performance of students in public junior secondary schools (JSS) in the Central Senatorial District of Delta State, Nigeria. The population was all the 173 public JSS and their principals from which a sample of twenty ...

  18. Are Teacher and Principal Candidates Prepared to Address Student Cyberbullying?

    Science.gov (United States)

    Styron, Ronald A., Jr.; Bonner, Jessica L.; Styron, Jennifer L.; Bridgeforth, James; Martin, Cecelia

    2016-01-01

    The purpose of this study was to examine the preparation of teacher and principal candidates to address problems created in K-12 settings as a result of cyberbullying. Participants included teacher and principal preparation students. Findings indicated that respondents were familiar with the most common forms of cyberbullying and its impact on…

  19. Comments: Should Principal Stratification Be Used to Study Mediational Processes?

    Science.gov (United States)

    VanderWeele, Tyler J.

    2012-01-01

    Principal stratification provides an approach to study the effect of an exposure on an outcome within strata defined by the effect of the exposure on some third, posttreatment, variable (Frangakis & Rubin, 2002). There has been more recent interest in using principal stratification to study the extent to which the effect of an exposure on an…

  20. Leading with Heart: Urban Elementary Principals as Advocates for Students

    Science.gov (United States)

    Rodriguez, Mariela A.; Murakami-Ramalho, Elizabeth; Ruff, William G.

    2009-01-01

    Principals in urban settings serve elementary schools often densely populated with highly mobile, ethnically diverse, and economically disadvantaged students. Due to the changing landscape of increasing accountability issues required by the "No Child Left Behind Act (NCLB)" (2001), principals must adjust the mission of the school…

  1. Latina/o School Principals: Identity, Leadership and Advocacy

    Science.gov (United States)

    Murakami, Elizabeth T.; Hernandez, Frank; Mendez-Morse, Sylvia; Byrne-Jimenez, Monica

    2016-01-01

    This study sought to further define and inform about the influence of Latina/o principals in schools as an alternative to traditional forms of leadership. The principals' Latina/o identity, their leadership styles and advocacy towards the improvement of student achievement were examined. This research focused on three questions: (a) How did…

  2. "Mujeres" in the Principal's Office: Latina School Leaders

    Science.gov (United States)

    Méndez-Morse, Sylvia; Murakami, Elizabeth T.; Byrne-Jiménez, Mónica; Hernandez, Frank

    2015-01-01

    This article is based on a national survey of Latina/o principals and assistant principals conducted by the National Latina/o Leadership Project and focuses on the women participants. Included is a description of Latinas' leadership experiences, their career paths, and the influence of racial/ethnic identity on their leadership practice. The…

  3. The Forgotten Aspect of Communication: Principals' Listening Skills

    Science.gov (United States)

    Woods, Jerry; Shoho, Alan R.

    2009-01-01

    This study investigated principals' self-perceptions and teachers' perceptions of principals' listening skills. An instrument measuring perception of listening skills was developed on the basis of four listening factors: attending, empathy, response, and trustworthiness. Factor analysis confirmed the structure of the new listening instrument, and…

  4. Principal curves for identifying outsiders in experimental tests with calorimeters

    CERN Document Server

    Da Silva, P V M

    2003-01-01

    Principal curves are used for particle discrimination. They are developed for application in calibration tests of the hadronic calorimeter (Tilecal) of the ATLAS detector. Defining principal curves for electrons, pions and muons, a discrimination efficiency better than 92.4% can be achieved, even when high particle contamination is observed in the experimental data sets.

  5. 3D face recognition with asymptotic cones based principal curvatures

    KAUST Repository

    Tang, Yinhang

    2015-05-01

    The classical curvatures of smooth surfaces (Gaussian, mean and principal curvatures) have been widely used in 3D face recognition (FR). However, facial surfaces resulting from 3D sensors are discrete meshes. In this paper, we present a general framework and define three principal curvatures on discrete surfaces for the purpose of 3D FR. These principal curvatures are derived from the construction of asymptotic cones associated to any Borel subset of the discrete surface. They describe the local geometry of the underlying mesh. First two of them correspond to the classical principal curvatures in the smooth case. We isolate the third principal curvature that carries out meaningful geometric shape information. The three principal curvatures in different Borel subsets scales give multi-scale local facial surface descriptors. We combine the proposed principal curvatures with the LNP-based facial descriptor and SRC for recognition. The identification and verification experiments demonstrate the practicability and accuracy of the third principal curvature and the fusion of multi-scale Borel subset descriptors on 3D face from FRGC v2.0.

  6. Discretion in Student Discipline: Insight into Elementary Principals' Decision Making

    Science.gov (United States)

    Findlay, Nora M.

    2015-01-01

    Little research exists that examines the exercise of discretion by principals in their disciplinary decision making. This study sought to understand the application of values by principals as they engage in student disciplinary decision making within legally fixed parameters of their administrative discretion. This qualitative methodology used…

  7. Principals' Perceptions of Their Knowledge in Special Education

    Science.gov (United States)

    Roberts, Maria Banda; Guerra, Federico R., Jr.

    2017-01-01

    With the "Every Student Succeeds Act" continuing to legislate accountability for special education and Hispanic students, the appropriate content in principal preparation programs relevant to successful leadership of special education programs is vital. This mixed methods study analyzed the survey responses of 84 principals in South…

  8. Principals' Perceptions of Needs in Hispanic Special Education

    Science.gov (United States)

    Roberts, Maria B.; Guerra, Federico, Jr.

    2017-01-01

    This mixed methods study used a survey by Frost and Kersten to answer the following questions: (a) Do principals of predominantly Hispanic schools perceive themselves as having adequate knowledge in special education? (b) Which areas are these principals most involved in with special education teachers? (c) What suggestions do these principals…

  9. High School Principals and the High School Journalism Program.

    Science.gov (United States)

    Peterson, Jane W.

    A study asked selected high school principals to respond to statements about the value of high school journalism to the high school student and about the rights and responsibilities of the high school journalist. These responses were then checked against such information as whether or not the high school principal had worked on a high school…

  10. Relationship between Implicit Leadership and Proactive Behaviors of School Principals

    Science.gov (United States)

    Keskinkilic-Kara, Sultan-Bilge; Zafer-Gunes, Demet

    2017-01-01

    The aim of this research is to define the school principals' implicit leadership theory and to reveal its relationship with the proactive behavior. The study is conducted in Bagcilar and Basaksehir districts in Istanbul and the target population of the research is 153 school principals working in state elementary schools, middle schools and high…

  11. An Introductory Application of Principal Components to Cricket Data

    Science.gov (United States)

    Manage, Ananda B. W.; Scariano, Stephen M.

    2013-01-01

    Principal Component Analysis is widely used in applied multivariate data analysis, and this article shows how to motivate student interest in this topic using cricket sports data. Here, principal component analysis is successfully used to rank the cricket batsmen and bowlers who played in the 2012 Indian Premier League (IPL) competition. In…

  12. From Redistribution to Recognition: How School Principals Perceive Social Justice

    Science.gov (United States)

    Wang, Fei

    2016-01-01

    Where there are people, there is social in/justice. Using Nancy Fraser's framework, this qualitative research examines how school principals perceive social justice in schools. Twenty-one elementary and secondary school principals were interviewed in the Greater Toronto Area. The study provides some empirical evidence on the ways social…

  13. School Principals' Technology Leadership Competency and Technology Coordinatorship

    Science.gov (United States)

    Banoglu, Koksal

    2011-01-01

    The aim of this study is to determine the primary and high school principals' competency in technology leadership and so to define implications for advanced competency. The population of the study was formed by 134 school principals in Maltepe and Kadikoy districts in Istanbul. On account of the fact that population was reachable, no specific…

  14. Teacher Contract Non-Renewal: What Matters to Principals?

    Science.gov (United States)

    Nixon, Andy; Packard, Abbot; Dam, Margaret

    2016-01-01

    This quantitative study investigated the relationship between teacher dispositions, subject content knowledge, pedagogical content knowledge, and reasons that school principals recommend non-renewal of teachers' contracts. Nearly 2,000 school principals in 13 states completed an emailed survey. In deciding whether to non-renew a teacher contract,…

  15. Empowering principals to lead and manage public schools ...

    African Journals Online (AJOL)

    Globally, education systems have been affected by radical social, political and economic changes. Although school principals play a pivotal role in improving student learning and attaining educational outcomes, they work under strenuous conditions to deal with multifaceted transformational issues. Principals experience ...

  16. Exploratory principal components analysis of growth traits in Red ...

    African Journals Online (AJOL)

    Exploratory principal components analysis of growth traits in Red Sokoto goats. ... Similar prediction pattern is obtained for CWT. ... similarity of intercepts of regression equations and those of average values for growth traits in this study indicated the possibility of improvement of goat stocks through the principal components.

  17. Financial accountability: the principal or the school governing body ...

    African Journals Online (AJOL)

    The Schools Act 84 of 1996 prescribes how a school should manage its funds. It also provides guidelines for the school governing body and the principal on their roles and responsibilities in managing the finances of the school. However, there are school governing bodies and principals that have little knowledge of the ...

  18. Perceptions of Women Principals' Leadership and Teachers' Work Attitudes.

    Science.gov (United States)

    Shum, Lai Ching; Cheng, Yin Cheong

    1997-01-01

    Investigates the relationship between perceptions of women principals' leadership (regarding sex-role orientation and leadership functions) and teachers' work attitudes (regarding sense of efficacy, community, and professional interest) in a sample of teachers supervised by women principals in Hong Kong secondary schools. Findings do show…

  19. Dynamic Leadership Succession: Strengthening Urban Principal Succession Planning

    Science.gov (United States)

    Peters-Hawkins, April L.; Reed, Latish C.; Kingsberry, Francemise

    2018-01-01

    The Dynamic Leadership Succession model is used to analyze a leadership succession case in an urban school district. The qualitative findings show that the district did not forecast school leadership needs well; however, the principal sought to develop and mentor teacher leaders as her assistant principals. Second, sustaining efforts within the…

  20. High School Principals as Leaders: Styles and Sources of Power

    Science.gov (United States)

    Brinia, Vasiliki; Papantoniou, Eva

    2016-01-01

    Purpose: The purpose of this paper is to present the characteristics of leadership (style adopted, sources of power exercised and factors affecting leadership) of high school principals in Greece. Design/Methodology/Approach: In total, 235 school principals were surveyed using questionnaires. These questionnaires assessed how often they adopted…