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Sample records for disc space induces

  1. Disc space distraction is a potent risk factor for adjacent disc disease after PLIF.

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    Kaito, Takashi; Hosono, Noboru; Fuji, Takeshi; Makino, Takahiro; Yonenobu, Kazuo

    2011-11-01

    We reported that excessive disc space distraction caused by insertion of large cages during posterior lumbar interbody fusion (PLIF) combined with pedicle screws (PS) induces adjacent segment disease (ASD). Spinous process plate (SPP) is known to allow cage subsidence when used in PLIF, since they cannot share vertical loads. We therefore hypothesize that the incidence of ASD after PLIF with SPP should be lower than that after PLIF with PS due to this loss of disc space distraction. Radiographic ASD is defined as development of spondylolisthesis > 3 mm, decrease in disc height > 3 mm, or intervertebral angle at flexion lesser than -5°. Symptomatic ASD is defined by a decrease of ≥ 4 points in Japanese Orthopedic Association score. One hundred and thirty patients with L4 spondylolisthesis were treated with either PLIF with SPP (n = 45) or PLIF with PS (n = 85) and followed up for a minimum of 2 years (mean, 39.0 months). L4-5 disc space distraction in the SPP group was significantly smaller (0.4 mm) as compared to the PS group (1.8 mm). The incidence of clinical ASD in the SPP group (2%, 1/45) was also significantly less than that in the PS group (15%, 13/85). Multivariate analysis showed that disc space distraction was the most significant risk factor. Among various risk factors for ASD after PLIF, the excessive distraction of disc space proved to be a potent risk factor for ASD.

  2. Structures induced by companions in galactic discs

    CERN Document Server

    Kyziropoulos, P; Gravvanis, G; Patsis, P

    2016-01-01

    Using N-body simulations we study the structures induced on a galactic disc by repeated flybys of a companion in decaying eccentric orbit around the disc. Our system is composed by a stellar disc, bulge and live dark matter halo, and we study the system's dynamical response to a sequence of a companion's flybys, when we vary i) the disc's temperature (parameterized by Toomre's Q-parameter) and ii) the companion's mass and initial orbit. We use a new 3D Cartesian grid code: MAIN (Mesh-adaptive Approximate Inverse N-body solver). The main features of MAIN are reviewed, with emphasis on the use of a new Symmetric Factored Approximate Sparse Inverse (SFASI) matrix in conjunction with the multigrid method that allows the efficient solution of Poisson's equation in three space variables. We find that: i) companions need to be assigned initial masses in a rather narrow window of values in order to produce significant and more long-standing non-axisymmetric structures (bars and spirals) in the main galaxy's disc by t...

  3. Magnetic resonance imaging of disc space infection revisited: temporal changes

    Institute of Scientific and Technical Information of China (English)

    Duan Shaoyin; Xu Bingqiang; Gina Di Primio; Cheemun Lum; Mark E Schweitzer

    2014-01-01

    Background Magnetic resonance imaging (MRI) has advantages in showing pathologic changes of disc space infection,which is important in clinical treatment.The purpose of this study was to describe the MRI findings of disc space infections in relation to chronicity.Methods MRI of 60 patients from January 1,2002 to April 30,2012 in Ottawa Hospital were retrospectively evaluated by two radiologists blindly.All patients had histological confirmation,with 55 having microbiological confirmation as well.These patients were divided into acute (n=18),subacute (n=21) and chronic (n=21) based on histological findings.The following potential signs of MRI finding were assessed:marrow edema,endplate erosions,disk fluid and height change,paraspinal mass,epidural collection,facet fluid and enhancement in the marrow,disc,paraspinal mass,and epidural involvement.Statistical analysis consisted of t-or F-tests and chi-square test.Results In the 60 patients,83 infected discs (single disc in 45 patients,2-4 discs in 15 patients) were found,including 22 discs in the acute group,30 discs in the subacute group,and 31 discs in the chronic group.There was a significant difference in the extent of marrow edema between the acute,subacute and chronic groups (P <0.05),with a gradually increasing extent from acute to chronic.The extent of endplate erosions increased with chronicity,but was not statistically significant.There were significant differences in the disc fluid,epidural collection,and disc enhancement among the acute,subacute and chronic groups,as well as the facet fluid between acute and chronic groups (P <0.05).There were no significant differences in the present probability of disc height loss,paraspinal mass,and marrow enhancement among the three groups (P >0.05).Conclusions From acute to chronic infections,the extent of marrow edema and endplate erosions appeared to gradually increase.Epidural collections and facet fluid are most frequently found in the acute group,while disc

  4. Debris disc formation induced by planetary growth

    CERN Document Server

    Kobayashi, Hiroshi

    2014-01-01

    Several hundred stars older than 10 million years have been observed to have infrared excesses. These observations are explained by dust grains formed by the collisional fragmentation of hidden planetesimals. Such dusty planetesimal discs are known as debris discs. In a dynamically cold planetesimal disc, collisional coagulation of planetesimals produces planetary embryos which then stir the surrounding leftover planetesimals. Thus, the collisional fragmentation of planetesimals that results from planet formation forms a debris disc. We aim to determine the properties of the underlying planetesimals in debris discs by numerically modelling the coagulation and fragmentation of planetesimal populations. The brightness and temporal evolution of debris discs depend on the radial distribution of planetesimal discs, the location of their inner and outer edges, their total mass, and the size of planetesimals in the disc. We find that a radially narrow planetesimal disc is most likely to result in a debris disc that ...

  5. Audiovisual Bounce-Inducing Effect: Attention Alone Does Not Explain Why the Discs Are Bouncing

    Science.gov (United States)

    Grassi, Massimo; Casco, Clara

    2009-01-01

    Two discs moving from opposite points in space, overlapping and stopping at the other disc's starting point, can be seen as either bouncing or streaming through each other. With silent displays, observers report the discs as streaming, whereas if a sound is played when the discs touch each other, observers report the discs as bouncing. The origin…

  6. Simulations of minor mergers - II. The phase-space structure of thick discs

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    Villalobos, Alvaro; Helmi, Amina

    2009-01-01

    We analyse the phase-space structure of simulated thick discs that are the result of a 5:1 mass-ratio merger between a disc galaxy and a satellite. Our main goal is to establish what would be the imprints of a merger origin for the Galactic thick disc. We find that the spatial distribution predicted

  7. Simulations of minor mergers. II. The phase-space structure of thick discs

    NARCIS (Netherlands)

    Villalobos, ´Alvaro; Helmi, Amina

    2009-01-01

    We analyse the phase-space structure of simulated thick discs that are the result of a significant merger between a disc galaxy and a satellite. Our main goal is to establish what would be the characteristic imprints of a merger origin for the Galactic thick disc. We find that the spatial distributi

  8. Regeneration of spine disc and joint cartilages under temporal and space modulated laser radiation

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    Sobol, E.; Shekhter, A.; Baskov, A.; Baskov, V.; Baum, O.; Borchshenko, I.; Golubev, V.; Guller, A.; Kolyshev, I.; Omeltchenko, A.; Sviridov, A.; Zakharkina, O.

    2009-02-01

    The effect of laser radiation on the generation of hyaline cartilage in spine disc and joints has been demonstrated. The paper considers physical processes and mechanisms of laser regeneration, presents results of investigations aimed to optimize laser settings and to develop feedback control system for laser reconstruction of spine discs. Possible mechanisms of laser-induced regeneration include: (1) Space and temporary modulated laser beam induces nonhomogeneous and pulse repetitive thermal expansion and stress in the irradiated zone of cartilage. Mechanical effect due to controllable thermal expansion of the tissue and micro and nano gas bubbles formation in the course of the moderate (up to 45-50 oC) heating of the NP activate biological cells (chondrocytes) and promote cartilage regeneration. (2) Nondestructive laser radiation leads to the formation of nano and micro-pores in cartilage matrix. That promotes water permeability and increases the feeding of biological cells. Results provide the scientific and engineering basis for the novel low-invasive laser procedures to be used in orthopedics for the treatment cartilages of spine and joints. The technology and equipment for laser reconstruction of spine discs have been tested first on animals, and then in a clinical trial. Since 2001 the laser reconstruction of intervertebral discs have been performed for 340 patients with chronic symptoms of low back or neck pain who failed to improve with non-operative care. Substantial relief of back pain was obtained in 90% of patients treated who returned to their daily activities. The experiments on reparation of the defects in articular cartilage of the porcine joints under temporal and spase modulated laser radiation have shown promising results.

  9. Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study.

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    Ariga, Kenta; Yonenobu, Kazuo; Nakase, Takanobu; Hosono, Noboru; Okuda, Shin'ya; Meng, Wenxiang; Tamura, Yuichi; Yoshikawa, Hideki

    2003-07-15

    Various amounts of static mechanical load were applied to mouse intervertebral discs in organ cultures. The apoptosis then was examined using nick end labeling. Two mitogen-activated protein kinase (MAPK) inhibitors were added to the medium. To establish an experimental model for detecting factors regulating chondrocyte apoptosis induced by mechanical stress, and to determine the role of MAPK and p38 in the stress-induced apoptotic pathway of endplate chondrocytes. The cause of degenerative change in the cartilaginous endplate (CEP) remains unclear. The authors' previous findings using a mouse model suggested that apoptosis in the cartilaginous endplate may play a role in intervertebral disc degeneration, and that mechanical stress may induce apoptosis. If apoptosis of endplate chondrocytes is involved in the cascade of intervertebral disc degeneration, then how apoptosis is induced by mechanical stress should be important in preventing disc degeneration. However, the mechanism of apoptosis induced by mechanical stress remains unclear. Mouse coccygeal discs were harvested and organ cultured. Various static compression loads (0, 0.2, 0.4, 0.8, and 1.0 MPa) were applied on intervertebral discs placed in culture bottles for 24 hours. Paraffin-embedded sections of the harvested discs were stained using Safranin-O and the nick end labeling procedure. The apoptotic cells were counted in the cartilaginous endplate and junctional anulus fibrosus of each intervertebral disc. In addition, U0126 (MAPK inhibitor) and SB202190 (p38 inhibitor) were added to the culture medium to determine their regulatory roles in the apoptosis of endplate chondrocytes induced by mechanical load. Histologically, loaded discs became bulged, and the disc space became narrow. Apoptosis was absent in discs without load, but was particularly noticeable in loaded discs (load weight, 1.0 MPa). The number of apoptotic cells increased depending on the weight of the load. The two MAPK inhibitors

  10. Minimizing cryopreservation-induced loss of disc cell activity for storage of whole intervertebral discs

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    SCW Chan

    2010-06-01

    Full Text Available Severe intervertebral disc (IVD degeneration often requires disc excision and spinal fusion, which leads to loss of spinal segment mobility. Implantation of an allograft disc or tissue engineered disc construct emerges as an alternative to artificial disc replacement for preserving the motion of the degenerated level. Establishment of a bank of cadaveric or engineered cryopreserved discs enables size matching, and facilitates clinical management. However, there is a lack of understanding of the behaviour of disc cells during cryopreservation, as well as how to maximize their survival, such that disc graft properties can be preserved. Here, we report on the effect of alterations in cooling rates, cryoprotective agents (CPAs, and duration of pre-cryopreservation incubation in CPA on cellular activity in whole porcine lumbar discs. Our results indicated that cooling rates of -0.3°C/min and -0.5°C /min resulted in the least loss of metabolic activity in nucleus pulposus (NP and annulus fibrosus (AF respectively, while metabolic activity is best maintained by using a combination of 10% dimethylsulphoxide (DMSO and 10% propylene-glycol (PG as CPA. By the use of such parameters, metabolic activity of the NP and the AF cells could be maintained at 70% and 45%, respectively, of that of the fresh tissue. Mechanical testing and histological evaluation showed no significant differences in mechanical properties or alterations in disc structure compared to fresh discs. Despite the limitations of the animal model, our findings provide a framework for establishing an applicable cryopreservation protocol for human disc allografts or tissue-engineered disc constructs.

  11. State Space Formulas for a Solution of the Suboptimal Nehari Problem on the Unit Disc

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    Curtain, Ruth F.; Opmeer, Mark R.

    2009-01-01

    We give state space formulas for a ("central") solution of the suboptimal Nehari problem for functions defined on the unit disc and taking values in the space of bounded operators in separable Hilbert spaces. Instead of assuming exponential stability, we assume a weaker stability concept (the combin

  12. Determination of the intervertebral disc space from CT images of the lumbar spine

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    Korez, Robert; Å tern, Darko; Likar, Boštjan; Pernuš, Franjo; Vrtovec, Tomaž

    2014-03-01

    Degenerative changes of the intervertebral disc are among the most common causes of low back pain, where for individuals with significant symptoms surgery may be needed. One of the interventions is the total disc replacement surgery, where the degenerated disc is replaced by an artificial implant. For designing implants with good bone contact and continuous force distribution, the morphology of the intervertebral disc space and vertebral body endplates is of considerable importance. In this study we propose a method for the determination of the intervertebral disc space from three-dimensional (3D) computed tomography (CT) images of the lumbar spine. The first step of the proposed method is the construction of a model of vertebral bodies in the lumbar spine. For this purpose, a chain of five elliptical cylinders is initialized in the 3D image and then deformed to resemble vertebral bodies by introducing 25 shape parameters. The parameters are obtained by aligning the chain to the vertebral bodies in the CT image according to image intensity and appearance information. The determination of the intervertebral disc space is finally achieved by finding the planes that fit the endplates of the obtained parametric 3D models, and placing points in the space between the planes of adjacent vertebrae that enable surface reconstruction of the intervertebral disc space. The morphometric analysis of images from 20 subjects yielded 11:3 +/- 2:6, 12:1 +/- 2:4, 12:8 +/- 2:0 and 12:9 +/- 2:7 cm3 in terms of L1-L2, L2-L3, L3-L4 and L4-L5 intervertebral disc space volume, respectively.

  13. Trauma induces apoptosis in human thoracolumbar intervertebral discs

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    Ertel Wolfgang

    2006-05-01

    Full Text Available Abstract Background Vertebral fractures resulting from high energy trauma often comprise the risk of posttraumatic degenerative changes in the affected intervertebral discs (IVD. Particularly in conservatively treated patients, or in cases after implant removal of an exclusively posterior stabilization, consecutive disc degeneration and the associated functional losing of the spinal segment clearly represent detrimental treatment results. In this regard, apoptosis of IVD cells has been suggested to be involved in the critical changes of the extracellular matrix. Methods To investigate whether fractures of the vertebrae induce apoptosis in the affected IVD, disc tissue from patients (n = 17 undergoing open reduction and internal fixation of thoracolumbar spine fractures were analysed in regards to caspase activity, apoptosis-receptor expression levels and gene expression of apoptosis-regulating proteins such as Bax and Bcl-2. Healthy IVD tissue (n = 3 obtained from patients undergoing surgical resection of adjacent vertebrae were used as control samples. Results In contrast to healthy control IVD tissues, samples from traumatic thoracolumbar IVD showed positive TUNEL staining and a significant increase of caspase-3/7 activity. Interestingly, analyses of the initiator caspase-8 and -9 revealed significantly increased activation levels compared to control values, suggesting the coexistent activation of both the extrinsic (receptor-mediated and intrinsic (mitochondria-mediated apoptosis pathway. Accordingly, expression levels of the Fas receptor (FasR mRNA were significantly increased. Although the TNF receptor I (TNFR I was only slightly upregulated, corresponding TNFα from trauma IVD presented significantly increased mRNA expression values. Furthermore, traumatic IVD cells demonstrated significantly reduced expression of the mitochondria-bound anti-apoptotic Bcl-2, thereby maintaining baseline transcriptional levels of the pro-apoptotic Bax

  14. Disc amplitudes, picture changing and space-time actions

    CERN Document Server

    Becker, Katrin; Robbins, Daniel

    2011-01-01

    We study in detail the procedure for obtaining couplings of D-branes to closed string fields by evaluating string theory disc amplitudes. We perform a careful construction of the relevant vertex operators and discuss the effects of inserting the boundary state which encodes the presence of the D-brane. We confront the issue of non-decoupling of BRST-exact states and prove that the problem is evaded for the computations we need, thus demonstrating that our amplitudes are automatically gauge-invariant and independent of the distribution of picture charge. Finally, we compute explicitly the two-point amplitudes of two NS-NS fields or one NS-NS and one R-R field on the disc, and we carefully compare all the lowest order terms with predictions from supergravity.

  15. Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture

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    Qian-Qian Liang

    2014-01-01

    Full Text Available Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX-2, and inducible nitric oxide synthase (iNOS expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.

  16. Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration.

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    João W Silveira

    Full Text Available Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have not been investigated yet. The present study investigated the effects of cannabidiol intradiscal injection in the coccygeal intervertebral disc degeneration induced by the needle puncture model using magnetic resonance imaging (MRI and histological analyses. Disc injury was induced in the tail of male Wistar rats via a single needle puncture. The discs selected for injury were punctured percutaneously using a 21-gauge needle. MRI and histological evaluation were employed to assess the results. The effects of intradiscal injection of cannabidiol (30, 60 or 120 nmol injected immediately after lesion were analyzed acutely (2 days by MRI. The experimental group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses 15 days after lesion/cannabidiol injection. The needle puncture produced a significant disc injury detected both by MRI and histological analyses. Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture. Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration.

  17. Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration.

    Science.gov (United States)

    Silveira, João W; Issy, Ana Carolina; Castania, Vitor A; Salmon, Carlos E G; Nogueira-Barbosa, Marcello H; Guimarães, Francisco S; Defino, Helton L A; Del Bel, Elaine

    2014-01-01

    Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have not been investigated yet. The present study investigated the effects of cannabidiol intradiscal injection in the coccygeal intervertebral disc degeneration induced by the needle puncture model using magnetic resonance imaging (MRI) and histological analyses. Disc injury was induced in the tail of male Wistar rats via a single needle puncture. The discs selected for injury were punctured percutaneously using a 21-gauge needle. MRI and histological evaluation were employed to assess the results. The effects of intradiscal injection of cannabidiol (30, 60 or 120 nmol) injected immediately after lesion were analyzed acutely (2 days) by MRI. The experimental group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses 15 days after lesion/cannabidiol injection. The needle puncture produced a significant disc injury detected both by MRI and histological analyses. Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture. Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration.

  18. Changes seen on magnetic resonance imaging in the intervertebral disc space after chemonucleosis: a hypothesis concerning regeneration of the disc after chemonucleosis

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    Kato, F.; Mimatsu, K.; Kawakami, N.; Miura, T. (Dept. of Orthopaedic Surgery, School of Medicine, Nagoya Univ. (Japan))

    1992-08-01

    Measurements of the intervertebral disc space were made by magnetic resonance imaging and plain film examinations over a period of 2 years in 26 patients who had undergone chemonucleolysis. The height of the posterior portion of the disc decreased after 3 months and never recovered; the height of the anterior portion also decreased but recovered slightly over the same period. The angle of lordosis and the range of motion in the treated segment were decreased, but recovered. Marked decrease in signal from the disc was observed after 2 weeks which did not recover till 2 years after chemonucleolysis. We suspect that the disc degenerated markedly after chemonucleolysis and changed into a type of scar tissue, maturation of which could stabilize the affected segment. (orig.).

  19. The Vertical Structure of Planet-induced Gaps in Proto-Planetary Discs

    CERN Document Server

    Edgar, R G

    2007-01-01

    Giant planets embedded in circumstellar discs are expected to open gaps in these discs. We examine the vertical structure of the gap edges. We find that the planet excites spiral arms with significant (Mach number of a half) vertical motion of the gas, and discuss the implications of these motions. In particular, the spiral arms will induce strong vertical stirring of the dust, making the edge appeared `puffed up' relative to the bulk of the disc. Infra-red observations (sensitive to dust) would be dominated by the light from the thick inner edge of the disc. Sub-millimetre observations (sensitive to gas velocities) would appear to be hot in `turbulent' motions (actually the ordered motion caused by the passage of the spiral arms), but cold in chemistry. Resolved sub-millimetre maps of circumstellar discs might even be able to detect the spiral arms directly.

  20. Nulling interferometry: performance comparison between space and ground-based sites for exozodiacal disc detection

    CERN Document Server

    Defrère, D; Foresto, V Coudé du; Danchi, W C; Hartog, R den

    2008-01-01

    Characterising the circumstellar dust around nearby main sequence stars is a necessary step in understanding the planetary formation process and is crucial for future life-finding space missions such as ESA's Darwin or NASA's Terrestrial Planet Finder (TPF). Besides paving the technological way to Darwin/TPF, the space-based infrared interferometers Pegase and FKSI (Fourier-Kelvin Stellar Interferometer) will be valuable scientific precursors in that respect. In this paper, we investigate the performance of Pegase and FKSI for exozodiacal disc detection and compare the results with ground-based nulling interferometers. Besides their main scientific goal (characterising hot giant extrasolar planets), Pegase and FKSI are very efficient in assessing within a few minutes the level of circumstellar dust in the habitable zone around nearby main sequence stars. They are capable of detecting exozodiacal discs respectively 5 and 1 time as dense as the solar zodiacal cloud and they outperform any ground-based instrumen...

  1. CT and MRI Determination of Intermuscular Space within Lumbar Paraspinal Muscles at Different Intervertebral Disc Levels.

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    Xuefei Deng

    Full Text Available Recognition of the intermuscular spaces within lumbar paraspinal muscles is critically important for using the paramedian muscle-splitting approach to the lumbar spine. As such, it is important to determine the intermuscular spaces within the lumbar paraspinal muscles by utilizing modern medical imaging such as computed tomography (CT and magnetic resonance imaging (MRI.A total of 30 adult cadavers were studied by sectional anatomic dissection, and 60 patients were examined using CT (16 slices, 3-mm thickness, 3-mm intersection gap, n = 30 and MRI (3.0T, T2-WI, 5-mm thickness, 1-mm intersection gap, n = 30. The distances between the midline and the superficial points of the intermuscular spaces at different intervertebral disc levels were measured.Based on study of our cadavers, the mean distances from the midline to the intermuscular space between multifidus and longissimus, from intervertebral disc levels L1-L2 to L5-S1, were 0.9, 1.1, 1.7, 3.0, and 3.5 cm, respectively. Compared with the upper levels (L1-L3, the superficial location at the lower level (L4-S1 is more laterally to the midline (P<0.05. The intermuscular space between sacrospinalis and quadratus lumborum, and that between longissimus and iliocostalis did not exist at L4-S1. The intermuscular spaces in patients also varied at different levels of the lumbar spine showing a low discontinuous density in CT and a high signal in MRI. There were no significant differences between the observations in cadavers and those made using CT and MRI.The intermuscular spaces within the paraspinal muscles vary at different intervertebral disc levels. Preoperative CT and MRI can facilitate selection of the muscle-splitting approach to the lumbar spine. This paper demonstrates the efficacy of medical imaging techniques in surgical planning.

  2. CT and MRI Determination of Intermuscular Space within Lumbar Paraspinal Muscles at Different Intervertebral Disc Levels

    Science.gov (United States)

    Wang, Shidong; Zhang, Yu; Han, Hui; Zheng, Dengquan; Ding, Zihai; Wong, Kelvin K. L.

    2015-01-01

    Background Recognition of the intermuscular spaces within lumbar paraspinal muscles is critically important for using the paramedian muscle-splitting approach to the lumbar spine. As such, it is important to determine the intermuscular spaces within the lumbar paraspinal muscles by utilizing modern medical imaging such as computed tomography (CT) and magnetic resonance imaging (MRI). Methods A total of 30 adult cadavers were studied by sectional anatomic dissection, and 60 patients were examined using CT (16 slices, 3-mm thickness, 3-mm intersection gap, n = 30) and MRI (3.0T, T2-WI, 5-mm thickness, 1-mm intersection gap, n = 30). The distances between the midline and the superficial points of the intermuscular spaces at different intervertebral disc levels were measured. Results Based on study of our cadavers, the mean distances from the midline to the intermuscular space between multifidus and longissimus, from intervertebral disc levels L1–L2 to L5–S1, were 0.9, 1.1, 1.7, 3.0, and 3.5 cm, respectively. Compared with the upper levels (L1–L3), the superficial location at the lower level (L4–S1) is more laterally to the midline (Pquadratus lumborum, and that between longissimus and iliocostalis did not exist at L4–S1. The intermuscular spaces in patients also varied at different levels of the lumbar spine showing a low discontinuous density in CT and a high signal in MRI. There were no significant differences between the observations in cadavers and those made using CT and MRI. Conclusion The intermuscular spaces within the paraspinal muscles vary at different intervertebral disc levels. Preoperative CT and MRI can facilitate selection of the muscle-splitting approach to the lumbar spine. This paper demonstrates the efficacy of medical imaging techniques in surgical planning. PMID:26458269

  3. Acute trauma induced disc displacement without reduction and its sequelae

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    He, DongMei; Yang, XiuJuan; Wang, FeiYu; Yang, Chi; Dong, MinJun

    2016-01-01

    Acute traumatic temporomandibular joint disc displacement (ATDD) and its sequelae are not familiar for most surgeons. This study is to discuss its sequelae in cases without disc reduction after failed conservative treatment. From 2010 to 2015, 26 patients with 34 joints were included in the study. All patients had at least 3 months conservative treatment. Their maximal incisor opening (MIO) was measured during follow-ups and MRI examination was used to check the condylar bone degeneration. The mean follow-up for conservative treatment after admission was 8.69 months, the patients reached an average of 25.7 mm MIO. MRI showed condylar bone intact in 8 joints (23.5%), condylar surface bone destruction (Wilks IV, V stages) in 14 joints (41.2%), and severe bone resorption in 12 joints (35.3%). 15 patients with 23 joints were asked for surgical treatment after a mean conservative treatment of 5.4 months (3–12 months) to improve mouth opening and relieve chronic pain. 12 joints had total joint replacement (TJR). 11 joints had disc repositioning. Their mean MIO before operation was 19.8 mm and significantly improved to 33.9 mm after operation (p = 0.0000). ATDD may cause severe osteoarthritis or ankylosis. Disc repositioning and TJR could significantly improve MIO. PMID:27582054

  4. Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.

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    Pogorelov, Vladimir M; Nomura, Jun; Kim, Jongho; Kannan, Geetha; Ayhan, Yavuz; Yang, Chunxia; Taniguchi, Yu; Abazyan, Bagrat; Valentine, Heather; Krasnova, Irina N; Kamiya, Atsushi; Cadet, Jean Lud; Wong, Dean F; Pletnikov, Mikhail V

    2012-03-01

    Genetic factors involved in neuroplasticity have been implicated in major psychiatric illnesses such as schizophrenia, depression, and substance abuse. Given its extended interactome, variants in the Disrupted-In-Schizophrenia-1 (DISC1) gene could contribute to drug addiction and psychiatric diseases. Thus, we evaluated how dominant-negative mutant DISC1 influenced the neurobehavioral and molecular effects of methamphetamine (METH). Control and mutant DISC1 mice were studied before or after treatment with non-toxic escalating dose (ED) of METH. In naïve mice, we assessed METH-induced conditioned place preference (CPP), dopamine (DA) D2 receptor density and the basal and METH-induced activity of DISC1 partners, AKT and GSK-3β in the ventral striatum. In ED-treated mice, 4 weeks after METH treatment, we evaluated fear conditioning, depression-like responses in forced swim test, and the basal and METH-induced activity of AKT and GSK-3β in the ventral striatum. We found impairment in METH-induced CPP, decreased DA D2 receptor density and altered METH-induced phosphorylation of AKT and GSK-3β in naïve DISC1 female mice. The ED regimen was not neurotoxic as evidenced by unaltered brain regional monoamine tissue content. Mutant DISC1 significantly delayed METH ED-produced sensitization and affected drug-induced phosphorylation of AKT and GSK-3β in female mice. Our results suggest that perturbations in DISC1 functions in the ventral striatum may impact the molecular mechanisms of reward and sensitization, contributing to comorbidity between drug abuse and major mental diseases.

  5. Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc.

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    Li, Yan; Li, Kang; Hu, Yiqin; Xu, Bo; Zhao, Jie

    2015-01-01

    Piperine is an exact of the active phenolic component from Black pepper. It has been reported to have many biological activities including anti-oxidant, anti-inflammatory and anti-tumor effects. Intervertebral disc degeneration (IDD) is a degenerative disease closely relate to inflammation of nucleus pulposus (NP) cells. This study aimed to assess the anti-inflammatory and anti-catabolic effects of piperine in rat intervertebral disc using in vitro and ex vivo analyzes. We demonstrated that piperine could inhibit LPS induced expression and production of inflammatory factors and catabolic proteases in NP cells culture model. It significantly inhibited multiple inflammatory factors and oxidative stress-associated genes (IL-1β, TNF-α, IL-6, iNOS), MMPs (MMP-3, MMP-13), ADAMTS (ADAMTS-4, ADAMTS-5) mRNA expression and NO production in a concentration-dependent manner. Moreover, piperine could reverse the LPS-induced inhibition of gene expression of aggrecan and collagen-II. Histologic and dimethylmethylene blue analysis indicated piperine could also against LPS induced proteoglycan (PG) depletion in a rat intervertebral disc culture model. Western blot results showed that piperine inhibited the LPS-mediated phosphorylation of JNK and activation of NF-κB. Finally, our results demonstrated the ability of piperine to antagonize LPS-mediated inflammation of NP cells and suppression of PG in rat intervertebral disc, suggesting a potential agent for treatment of IDD in future.

  6. Anterior herniation of lumbar disc induces persistent visceral pain:discogenic visceral pain

    Institute of Scientific and Technical Information of China (English)

    TANG Yuan-zhang; Moore-Langston Shannon; LAI Guang-hui; LI Xuan-ying; LI Na; NI Jia-xiang

    2013-01-01

    Background Visceral pain is a common cause for seeking medical attention.Afferent fibers innervating viscera project to the central nervous system via sympathetic nerves.The lumbar sympathetic nerve trunk lies in front of the lumbar spine.Thus,it is possible for patients to suffer visceral pain originating from sympathetic nerve irritation induced by anterior herniation of the lumbar disc.This study aimed to evaluate lumbar discogenic visceral pain and its treatment.Methods Twelve consecutive patients with a median age of 56.4 years were enrolled for investigation between June 2012 and December 2012.These patients suffered from long-term abdominal pain unresponsive to current treatment options.Apart from obvious anterior herniation of the lumbar discs and high signal intensity anterior to the herniated disc on magnetic resonance imaging,no significant pathology was noted on gastroscopy,vascular ultrasound,or abdominal computed tomography (CT).To prove that their visceral pain originated from the anteriorly protruding disc,we evaluated whether pain was relieved by sympathetic block at the level of the anteriorly protruding disc.If the block was effective,CT-guided continuous lumbar sympathetic nerve block was finally performed.Results All patients were positive for pain relief by sympathetic block.Furthermore,the average Visual Analog Scale of visceral pain significantly improved after treatment in all patients (P <0.05).Up to 11/12 patients had satisfactory pain relief at 1 week after discharge,8/12 at 4 weeks,7/12 at 8 weeks,6/12 at 12 weeks,and 5/12 at 24 weeks.Conclusions It is important to consider the possibility of discogenic visceral pain secondary to anterior herniation of the lumbar disc when forming a differential diagnosis for seemingly idiopathic abdominal pain.Continuous lumbar sympathetic nerve block is an effective and safe therapy for patients with discogenic visceral pain.

  7. Anterior herniation of lumbar disc induces persistent visceral pain: discogenic visceral pain: discogenic visceral pain.

    Science.gov (United States)

    Tang, Yuan-Zhang; Shannon, Moore-Langston; Lai, Guang-Hui; Li, Xuan-Ying; Li, Na; Ni, Jia-Xiang

    2013-01-01

    Visceral pain is a common cause for seeking medical attention. Afferent fibers innervating viscera project to the central nervous system via sympathetic nerves. The lumbar sympathetic nerve trunk lies in front of the lumbar spine. Thus, it is possible for patients to suffer visceral pain originating from sympathetic nerve irritation induced by anterior herniation of the lumbar disc. This study aimed to evaluate lumbar discogenic visceral pain and its treatment. Twelve consecutive patients with a median age of 56.4 years were enrolled for investigation between June 2012 and December 2012. These patients suffered from long-term abdominal pain unresponsive to current treatment options. Apart from obvious anterior herniation of the lumbar discs and high signal intensity anterior to the herniated disc on magnetic resonance imaging, no significant pathology was noted on gastroscopy, vascular ultrasound, or abdominal computed tomography (CT). To prove that their visceral pain originated from the anteriorly protruding disc, we evaluated whether pain was relieved by sympathetic block at the level of the anteriorly protruding disc. If the block was effective, CT-guided continuous lumbar sympathetic nerve block was finally performed. All patients were positive for pain relief by sympathetic block. Furthermore, the average Visual Analog Scale of visceral pain significantly improved after treatment in all patients (P pain relief at 1 week after discharge, 8/12 at 4 weeks, 7/12 at 8 weeks, 6/12 at 12 weeks, and 5/12 at 24 weeks. It is important to consider the possibility of discogenic visceral pain secondary to anterior herniation of the lumbar disc when forming a differential diagnosis for seemingly idiopathic abdominal pain. Continuous lumbar sympathetic nerve block is an effective and safe therapy for patients with discogenic visceral pain.

  8. Magnetization oscillations induced by spin current in a paramagnetic disc

    NARCIS (Netherlands)

    Slachter, Abraham; van Wees, Bart Jan

    2011-01-01

    When electron spins are injected uniformly into a paramagnetic disk, they can precess along the demagnetizing field induced by the resulting magnetic moment. Normally this precession damps out by virtue of the spin relaxation, which is present in paramagnetic materials. We propose a mechanism to exc

  9. Induction of early degeneration of the adjacent segment after posterior lumbar interbody fusion by excessive distraction of lumbar disc space.

    Science.gov (United States)

    Kaito, Takashi; Hosono, Noboru; Mukai, Yoshihiro; Makino, Takahiro; Fuji, Takeshi; Yonenobu, Kazuo

    2010-06-01

    Spinal fusion at the L4-5 disc space alters the normal biomechanics of the spine, and the loss of motion at the fused level is compensated by increased motion and load at the other unfused segments. This may lead to deterioration of the adjacent segments of the lumbar spine, called adjacent-segment disease (ASD). In this study, the authors investigate the distracted disc height of the fused segment, caused by cage or bone insertion during surgery, as a novel risk factor for ASD after posterior lumbar interbody fusion (PLIF). Radiographic L3-4 ASD is defined by development of spondylolisthesis greater than 3 mm, a decrease in disc height of more than 3 mm, or intervertebral angle at flexion smaller than -5 degrees . Symptomatic ASD is defined by a decrease of 4 points or more on the Japanese Orthopaedic Association scale. Eighty-five patients with L-4 spondylolisthesis treated by L4-5 PLIF underwent follow-up for more than 2 years (mean 38.8 +/- 17.1 months). The patients were divided into 3 groups according to the final outcome. Group A comprised those patients without ASD (58), Group B patients had radiographic ASD (14), and Group C patients had symptomatic ASD (13). The L4-5 disc space distraction by cage insertion was 3.1 mm in the group without ASD, 4.4 mm in the group with radiographic ASD, and 6.2 mm in the group with symptomatic ASD, as measured using lateral spinal radiographs just after surgery. Multivariate analysis showed that distraction was the most significant risk factor. The excessive distraction of the L4-5 disc space during PLIF surgery is a significant and potentially avoidable risk factor for the development of radiographic, symptomatic ASD.

  10. CT-discography; diagnostic accuracy in lumbar disc herniation and significance of induced pain during procedure

    Energy Technology Data Exchange (ETDEWEB)

    Jin, En Hao [Yan Bian Medical College, Beijing (China); Chung, Tae Sub; Jeong, Mi Gyoung; Kim, Young Soo; Roh, Sung Woo [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-01-01

    To evaluate the usefulness and the accuracy of CT-discography in lumbar disc disease by analyzing the findings of CT-discogram and types of evoked pain during the procedure. CT-discograms were retrospectively evaluated in 47 intervertebral discs of 20 patients with multilevel involvement of lumbar disc diseases. In 28 herniated discs confirmed at surgery, the findings of CT-discogram (28 disc levels/20 patients), MRI(23/16) and CT(21/15) were comparatively analysed. The type of pain after infusion of contrast media during CT-discography was compared with that prior to the procedure. The accuracy for determining types of the herniated lumbar disc when compared with post-operative results was 96.4%(27 discs/28 discs) in the CT-discogram, 82.6%(19 discs/23 discs) in MRI and 71.4%(15 discs/21 discs) in the CT scan. Pains encountered during discography were radiating pain in 12 discs and back pain in 24 discs. CT-discography was especially helpful in 10 patients with multilevel involvement of the lumbar disc diseases to evaluate the exact location of diseased disc(s) that provoked the pain. CT-discography is a highly accurate method in diagnosis of the herniated lumbar intervertebral discs and is very useful in determining the precise location related to the development of pain in such cases.

  11. cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes.

    Science.gov (United States)

    Bhattacharjee, Rajesh; Xiang, Wenpei; Wang, Yinna; Zhang, Xiaoying; Billiar, Timothy R

    2012-06-22

    Tumor necrosis factor α (TNF) is a pleiotropic proinflammatory cytokine that plays a role in immunity and the control of cell proliferation, cell differentiation, and apoptosis. The pleiotropic nature of TNF is due to the formation of different signaling complexes upon the binding of TNF to its receptor, TNF receptor type 1 (TNFR1). TNF induces apoptosis in various mammalian cells when the cells are co-treated with a transcription inhibitor like actinomycin D (ActD). When TNFR1 is activated, it recruits an adaptor protein, TNF receptor-associated protein with death domain (TRADD), through its cytoplasmic death effector domain (DED). TRADD, in turn, recruits other signaling proteins, including TNF receptor-associated protein 2 (TRAF2) and receptor-associated protein kinase (RIPK) 1, to form a complex. Subsequently, this complex combines with FADD and procaspase-8, converts into a death-inducing signaling complex (DISC) to induce apoptosis. Cyclic AMP (cAMP) is a second messenger that regulates various cellular processes such as cell proliferation, gene expression, and apoptosis. cAMP analogues are reported to act as anti-apoptotic agents in various cell types, including hepatocytes. We found that a cAMP analogue, dibutyryl cAMP (db-cAMP), inhibits TNF+ActD-induced apoptosis in rat hepatocytes. The protein kinase A (PKA) inhibitor KT-5720 reverses this inhibitory effect of cAMP on apoptosis. Cytoprotection by cAMP involves down-regulation of various apoptotic signal regulators like TRADD and FADD and inhibition of caspase-8 and caspase-3 cleavage. We also found that cAMP exerts its affect at the proximal level of TNF signaling by inhibiting the formation of the DISC complex upon the binding of TNF to TNFR1. In conclusion, our study shows that cAMP prevents TNF+ActD-induced apoptosis in rat hepatocytes by inhibiting DISC complex formation.

  12. cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharjee, Rajesh [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States); Xiang, Wenpei [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States); Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People' s Republic of China (China); Wang, Yinna [Vascular Medicine Institute, University of Pittsburgh School of Medicine, 10051-5A BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (United States); Zhang, Xiaoying [Department of Medicine/Endocrinology Division, University of Pittsburgh Medical Center, 200 Lothrop St., Pittsburgh, PA 15213 (United States); Billiar, Timothy R., E-mail: billiartr@upmc.edu [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States)

    2012-06-22

    Highlights: Black-Right-Pointing-Pointer cAMP blocks cell death induced by TNF and actinomycin D in cultured hepatocytes. Black-Right-Pointing-Pointer cAMP blocks NF-{kappa}B activation induced by TNF and actinomycin D. Black-Right-Pointing-Pointer cAMP blocks DISC formation following TNF and actinomycin D exposure. Black-Right-Pointing-Pointer cAMP blocks TNF signaling at a proximal step. -- Abstract: Tumor necrosis factor {alpha} (TNF) is a pleiotropic proinflammatory cytokine that plays a role in immunity and the control of cell proliferation, cell differentiation, and apoptosis. The pleiotropic nature of TNF is due to the formation of different signaling complexes upon the binding of TNF to its receptor, TNF receptor type 1 (TNFR1). TNF induces apoptosis in various mammalian cells when the cells are co-treated with a transcription inhibitor like actinomycin D (ActD). When TNFR1 is activated, it recruits an adaptor protein, TNF receptor-associated protein with death domain (TRADD), through its cytoplasmic death effector domain (DED). TRADD, in turn, recruits other signaling proteins, including TNF receptor-associated protein 2 (TRAF2) and receptor-associated protein kinase (RIPK) 1, to form a complex. Subsequently, this complex combines with FADD and procaspase-8, converts into a death-inducing signaling complex (DISC) to induce apoptosis. Cyclic AMP (cAMP) is a second messenger that regulates various cellular processes such as cell proliferation, gene expression, and apoptosis. cAMP analogues are reported to act as anti-apoptotic agents in various cell types, including hepatocytes. We found that a cAMP analogue, dibutyryl cAMP (db-cAMP), inhibits TNF + ActD-induced apoptosis in rat hepatocytes. The protein kinase A (PKA) inhibitor KT-5720 reverses this inhibitory effect of cAMP on apoptosis. Cytoprotection by cAMP involves down-regulation of various apoptotic signal regulators like TRADD and FADD and inhibition of caspase-8 and caspase-3 cleavage. We also found

  13. Effects of controlled dynamic disc distraction on degenerated intervertebral discs: an in vivo study on the rabbit lumbar spine model.

    Science.gov (United States)

    Kroeber, Markus; Unglaub, Frank; Guehring, Thorsten; Guegring, Thorsten; Nerlich, Andreas; Hadi, Tamer; Lotz, Jeffrey; Carstens, Claus

    2005-01-15

    An in vivo study on the rabbit lumbar spine model. Effects of temporary dynamic distraction on intervertebral discs were studied on the lumbar spine rabbit model to characterize the changes associated with disc distraction and to evaluate feasibility of temporary disc distraction to previously compressed discs in order to stimulate disc regeneration. Studies have shown that accelerated degeneration of the intervertebral disc results from altered mechanical loading conditions. The development of methods for the prevention of disc degeneration and the restoration of disc tissue that has already degenerated are needed. New Zealand white rabbits (n = 32) were used for this study. The rabbits were randomly assigned to one of five groups. In 12 animals, the discs were first loaded for 28 days using a custom-made external loading device to stimulate disc degeneration. After 28 days loading time, the discs in six animals were distracted for 7 days and in six animals for 28 days using the same external device, however, modified as dynamic distraction device. In six animals, the discs were distracted for 28 days without previous loading; and in six animals, the discs were loaded for 28 days and afterwards the loading device removed for 28 days for recovery without distraction. Six animals were sham operated. The external device was situated; however, the discs remained undistracted and they also served as controls. After 28 to 56 days loading and distraction time, the animals were killed and the lumbar spine was harvested for examination. Disc height, disc morphology, cell viability, relative neutral zone, and tangent modulus were measured. After 28 days of loading, the discs demonstrated a significant decrease in disc space. Histologically, disorganization of the architecture of the anulus occurred. The number of dead cells increased significantly in the anulus and cartilage endplate. These changes were reversible after 28 days of distraction. The disc thickness increased

  14. Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat

    OpenAIRE

    Liu, Chang-Cheng; Tian, Fa-Ming; Zhou, Zhuang; Wang, Peng; Gou, Yu; Zhang, Heng; Wang, Wen-Ya; Shen, Yong; Zhang, Ying-Ze; Zhang, Liu

    2015-01-01

    Background Intervertebral disc (IVD) degeneration and pathological changes in the spinal cord are major causes of back pain. In addition to its well-established anti-resorptive effect on bone, calcitonin (CT) potentially exerts protective effects on IVD degeneration in ovariectomized rats. However, possible therapeutic effects of CT on lumbar fusion-induced adjacent-segment disc degeneration (ASDD) have not been investigated yet. In this study, we examined the effects of CT on IVD degeneratio...

  15. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc

    Directory of Open Access Journals (Sweden)

    Yan Li

    2016-05-01

    Full Text Available Cordycepin is a component of the extract obtained from Cordyceps militaris and has many biological activities, including anti-cancer, anti-metastatic and anti-inflammatory effects. Intervertebral disc degeneration (IDD is a degenerative disease that is closely related to the inflammation of nucleus pulposus (NP cells. The effect of cordycepin on NP cells in relation to inflammation and degeneration has not yet been studied. In our study, we used a rat NP cell culture and an intervertebral disc (IVD organ culture model to examine the inhibitory effects of cordycepin on lipopolysaccharide (LPS-induced gene expression and the production of matrix degradation enzymes (MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 and oxidative stress-associated factors (nitric oxide and PGE2. We found a protective effect of cordycepin on NP cells and IVDs against LPS-induced matrix degradation and macrophage infiltration. In addition, western blot and luciferase assay results demonstrated that pretreatment with cordycepin significantly suppressed the LPS-induced activation of the NF-κB pathway. Taken together, the results of our research suggest that cordycepin could exert anti-inflammatory and anti-degenerative effects on NP cells and IVDs by inhibiting the activation of the NF-κB pathway. Therefore, cordycepin may be a potential treatment for IDD in the future.

  16. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine.

    Science.gov (United States)

    Liang, Qian-Qian; Cui, Xue-Jun; Xi, Zhi-Jie; Bian, Qin; Hou, Wei; Zhao, Yong-Jian; Shi, Qi; Wang, Yong-Jun

    2011-01-01

    An in vivo study of the cervical intervertebral discs (IVDs) response to upright posture was performed using an amputated bipedal rat model. To investigate the effects of upright posture on IVDs of rat cervical spine. The distinct arrangement of human neck muscle from that of cat and rhesus indicated that in the evolution process, upright posture might have affected cervical spine of human ancestors. However, the effects of upright posture on cervical spine have not been assessed. Forty-one-month-old rats were randomly divided into 5-month-control, 5-month-surgery, 7-month-control, and 7-month surgery group (n = 10 per group). Both forelimbs of 2 surgery group rats were amputated, and those rats were then induced to be upright in the custom-made cages. Two control group rats were kept in regular cages. These rats were respectively killed at the fifth and seventh month after surgery and the IVD samples of lumbar spine were harvested for histologic and immunohistochemical studies. Total RNA isolated from these samples were used for real-time polymerase chain reaction of type II collagen (Col2a1), type X collagen, matrix metalloproteinase 13 (MMP-13), MMP-3, aggre-can, and aggrecanase-2 (ADAMTS-5). Upright posture affects histologic changes of the cervical IVDs such as fissures of anulus fibrosus and decreased height of disc, decreased protein level of Col2a1 at nucleus pulposus and anulus fibrosus, up-regulated MMP-13, MMP-3, ADAMTS-5, and type X collagen mRNA expression, and downregulated mRNA expression of Col2a1 and aggrecan. Upright stance accelerates cervical disc degeneration in rats.

  17. Destruction of the germinal disc region of an immature preovulatory chicken follicle induces atresia and apoptosis.

    Science.gov (United States)

    Yao, H H; Volentine, K K; Bahr, J M

    1998-09-01

    The germinal disc region (GDR), which contains the germinal disc and overlying granulosa cells, is essential for completion of maturation of the preovulatory chicken follicle. The current study was conducted to test the hypothesis that destruction of the GDR (GDRX) of an immature preovulatory chicken follicle blocks ovulation, induces apoptosis, and causes atresia. The GDR of immature preovulatory follicles (F2) were destroyed by freezing with dry ice (3 mm in diameter) 48-50 h before ovulation. As a control for the effect of freezing, a nonGDR portion (a portion of the follicular wall opposite to the GDR relative to the follicular stalk) of other F2 follicles were destroyed (nonGDRX). Treatment of F2 follicles by GDRX caused atresia and blocked ovulation of all treated follicles (6 of 6), whereas none of the nonGDRX follicles (0 of 5) underwent atresia. Treatment of follicles by GDRX induced apoptotic DNA fragmentation (laddering) in theca and granulosa layers obtained from the frozen area and in the theca layer obtained from the follicular wall distal to the frozen area. In contrast, apoptosis was only present in theca and granulosa layers in the frozen area of the nonGDRX follicle. Furthermore, the in situ DNA end-labeling technique demonstrated that in the GDRX follicle 24 h after treatment, cells in the theca interna, endothelial cells in blood vessels of the theca externa, and a few granulosa cells underwent apoptosis. These results indicate that destruction of the GDR of an immature preovulatory follicle causes atresia and apoptosis and blocks ovulation. These novel findings suggest that the GDR maintains development of the chicken preovulatory follicle by producing one or more survival factors. Without the GDR, chicken follicles cannot develop further and they eventually die.

  18. Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc.

    Science.gov (United States)

    Li, Kang; Li, Yan; Xu, Bo; Mao, Lu; Zhao, Jie

    2016-09-01

    Intervertebral disc (IVD) degeneration contributes to most spinal degenerative diseases, while treatment inhibiting IVD degeneration is still in the experimental stage. Sesamin, a bioactive component extracted from sesame, has been reported to exert chondroprotective and anti-inflammatory effects. Here, we analyzed the anti-inflammatory and anti-catabolic effects of sesamin on rat IVD in vitro and ex vivo. Results show that sesamin significantly inhibits the lipopolysaccharide (LPS)-induced expression of catabolic enzymes (MMP-1, MMP-3, MMP-13, ADAMTS-4, ADAMTS-5) and inflammation factors (IL-1β, TNF-α, iNOS, NO, COX-2, PGE2) in a dose-dependent manner in vitro. It is also proven that migration of macrophages induced by LPS can be inhibited by treatment with sesamin. Organ culture experiments demonstrate that sesamin protects the IVD from LPS-induced depletion of the extracellular matrix ex vivo. Moreover, sesamin suppresses LPS-induced activation of the mitogen-activated protein kinase (MAPK) pathway through inhibiting phosphorylation of JNK, the common downstream signaling pathway of LPS and IL-1β, which may be the potential mechanism of the effects of sesamin. In light of our results, sesamin protects the IVD from inflammation and extracellular matrix catabolism, presenting positive prospects in the treatment of IVD degenerative diseases.

  19. Does the mass distribution in discs influence encounter-induced losses in young star clusters?

    CERN Document Server

    Steinhausen, Manuel

    2014-01-01

    One mechanism for the external destruction of protoplanetary discs in young dense clusters is tidal disruption during the flyby of another cluster member. The degree of mass loss in such an encounter depends, among other parameters, on the distribution of the material within the disc. Previous work showed that this is especially so in encounters that truncate large parts of the outer disc. The expectation is that the number of completely destroyed discs in a cluster depends also on the mass distribution within the discs. Here we test this hypothesis by determining the influence of encounters on the disc fraction and average disc mass in clusters of various stellar densities for different mass distributions in the discs. This is done by performing Nbody6 simulation of a variety of cluster environments, where we track the encounter dynamics and determine the mass loss due to these encounters for different disc-mass distributions. We find that although the disc mass distribution has a significant impact on the d...

  20. Laser-Induced Forward Transfer-printing of focused ion beam pre-machined crystalline magneto-optic yttrium iron garnet micro-discs.

    Science.gov (United States)

    Sones, C L; Feinaeugle, M; Sposito, A; Gholipour, B; Eason, R W

    2012-07-02

    We present femtosecond laser-induced forward transfer of focused ion beam pre-machined discs of crystalline magneto-optic yttrium iron garnet (YIG) films. Debris-free circular micro-discs with smooth edges and surface uniformity have been successfully printed. The crystalline nature of the printed micro-discs has not been altered by the LIFT printing process, as was confirmed via micro-Raman measurements.

  1. New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration.

    Science.gov (United States)

    Kroeber, Markus W; Unglaub, Frank; Wang, Haili; Schmid, Carsten; Thomsen, Marc; Nerlich, Andreas; Richter, Wiltrud

    2002-12-01

    A new rabbit model was developed that produces disc degeneration through the application of controlled and quantified axial mechanical load. To characterize the changes associated with disc degeneration, and to evaluate the feasibility of local transfer of agents to the compressed discs to stimulate disc regeneration. Studies have shown that accelerated degeneration of the intervertebral disc results from altered mechanical loading conditions. The development of methods for the prevention of disc degeneration and the restoration of disc tissue that has already degenerated is needed. New Zealand white rabbits (n = 33) were used for this study. The discs in five animals remained unloaded and served as controls, whereas in 28 animals the discs were axially compressed using a custom-made external loading device. After 1 (n = 7), 14 (n = 7), and 28 (n = 7) days of dynamic loading, or 28 (n = 7) days of loading followed by 28 days of unloaded recovery time, the animals were killed and the lumbar spine was harvested for tissue preparation. Disc height, disc morphology, cell viability, disc stiffness, and load to failure were measured. Recombinant adenovirus encoding for two different marker genes (Ad-Luciferase and Ad-LacZ) was injected into the discs in loaded specimens and the gene expression was measured. The unloaded intervertebral discs of the rabbits consisted of a layered anulus fibrosus, a cartilaginous endplate, and a nucleus pulposus comparable with those of humans. After 14 and 28 days of loading, the discs demonstrated a significant decrease in disc space. Histologically, disorganization of the architecture of the anulus occurred. The number of dead cells increased significantly in the anulus and cartilage endplate. These changes were not reversible after 28 days of unloading. The stiffness and the load to failure did not change significantly in the discs after 28 days of loading, as compared with the unloaded control discs. Adenovirus-mediated gene transfer

  2. The tidally induced warping, precession and truncation of accretion discs in binary systems three dimensional simulations

    CERN Document Server

    Larwood, J D; Papaloizou, J C B; Terquem, C

    1996-01-01

    We present the results of non linear, hydrodynamic simulations, in three dimensions, of the tidal perturbation of accretion discs in binary systems where the orbit is circular and not necessarily coplanar with the disc mid-plane. The accretion discs are assumed to be geometrically thin, and of low mass relative to the stellar mass so that they are governed by thermal pressure and viscosity, but not self-gravity. The parameters that we consider in our models are the ratio of the orbital distance to the disc radius, D/R, the binary mass ratio, the initial inclination angle between the orbit and disc planes and the Mach number in the outer parts of the unperturbed disc. For binary mass ratios of around unity and D/R in the range 3 to 4, we find that the global evolution of the discs is governed primarily by the value of the Mach number. For relatively low Mach numbers (i.e. 10 to 20) we find that the discs develop a mildly warped structure, are tidally truncated, and undergo a near rigid body precession at a rat...

  3. Black hole accretion discs

    CERN Document Server

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. outbursting black-hole low-mass X-ray binaries. We then turn to the role of advection in accretion flow onto black holes illustrating its action and importance with a toy model describing both ADAFs and slim discs. We conclude with a presentation of the general-relativistic formalism describing accretion discs in the Kerr space-time.

  4. Adjacent segment degeneration after single-level anterior cervical decompression and fusion: disc space distraction and its impact on clinical outcomes.

    Science.gov (United States)

    Li, Jia; Li, Yongqian; Kong, Fanlong; Zhang, Di; Zhang, Yingze; Shen, Yong

    2015-03-01

    The purpose of this study was to find whether excessive distraction of the disc space for cage insertion was a risk factor for adjacent segment degeneration (ASD) after anterior cervical decompression and fusion (ACDF). One hundred and sixteen consecutive patients who underwent ACDF for single-level cervical disc herniation between June 2006 and November 2008 were retrospectively reviewed. Preoperative, postoperative and final follow-up disc height (DH), sagittal segmental alignment (SSA), and sagittal alignment of the cervical spine (SACS) were measured and compared between the ASD group and non-ASD group. In 116 patients, ASD was radiographically proven in 28 (24.1%) patients. The clinical outcomes were significantly improved compared to the preoperative scores in both groups. However, the postoperative and final follow-up DH of the ASD group were significantly higher than in the non-ASD group (p<0.05). In addition, the postoperative DH was significantly correlated with the postoperative or final follow-up SSA (p<0.05). However, postoperative DH was not found to significantly correlate with postoperative or final follow-up SACS (p=0.072 and p=0.096, respectively). Multivariate analysis showed that postoperative DH was the most significant risk factor for ASD. The clinical outcomes of ACDF for single-level degenerative cervical disc disease were satisfactory. Postoperative DH (the distracted distance) had the greatest impact on the incidence of ASD. Excessive disc space distraction is a considerable risk factor for the development of radiographic ASD.

  5. [The synergistic effect of amygdalin and HSYA on the IL-1beta induced endplate chondrocytes of rat intervertebral discs].

    Science.gov (United States)

    Niu, Kai; Zhao, Yong-Jian; Zhang, Lei; Li, Chen-Guang; Wang, Yong-Jun; Zheng, Wei-Chao

    2014-08-01

    The effect of amygdalin joint hydroxysafflor yellow A (HSYA) on the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and the possible mechanism were studied and explored. Chondrocytes were obtained from endplate of one-month SD rat intervertebral discs and cultured primary endplate chondrocytes. After identification, they were divided into normal group, induced group, amygdalin group, HSYA group and combined group. CCK-8 kit was adopted to detect the proliferation of the endplate chondrocytes. FCM was measured to detect the apoptosis. Real-time PCR method was adopted to observe the mRNA expression of Aggrecan, Col 2 alpha1, Col 10 alpha1, MMP-13 and the inflammatory cytokines IL-1beta. The protein expression of Col II, Col X was tested through immunofluorescence. Compared with the normal group, the proliferation of the endplate chondrocytes decreased while the apoptosis increased (P amygdalin group, HSYA group, the combined group could inhibit the apoptosis and promote the proliferation (P amygdalin and HSYA. Amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of amygdalin or HSYA.

  6. An accretion disc instability induced by a temperature sensitive {\\alpha} parameter

    CERN Document Server

    Potter, William J

    2014-01-01

    In the standard thin disc formalism the dimensionless {\\alpha} parameter is usually assumed to be constant. However, there are good theoretical reasons for believing, as well as evidence from simulations, that {\\alpha} is dependent on intrinsic disc properties. In this paper we analyse the conditions for the stability of a thin accretion disc in which {\\alpha} is a function of the magnetic Prandtl number, the ratio of collisional viscosity to resistivity. In the inner disc, where the free electron opacity and radiation viscosity dominate, the disc is unstable if {\\alpha} is proportional to the magnetic Prandtl number with an exponent > 0.5. This is within the range of values for the power-law index found in MHD simulations with simple energetics. We calculate the evolution of the unstable disc within the {\\alpha} formalism and show that the physically accessible solutions form a limit cycle, analogous to the behaviour seen in recurrent dwarf novae. It is noteworthy that the time-dependent global behaviour of ...

  7. Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station.

    Science.gov (United States)

    Chang, Douglas G; Healey, Robert M; Snyder, Alexander J; Sayson, Jojo V; Macias, Brandon R; Coughlin, Dezba G; Bailey, Jeannie F; Parazynski, Scott E; Lotz, Jeffrey C; Hargens, Alan R

    2016-12-15

    Prospective case series. Evaluate lumbar paraspinal muscle (PSM) cross-sectional area and intervertebral disc (IVD) height changes induced by a 6-month space mission on the International Space Station. The long-term objective of this project is to promote spine health and prevent spinal injury during space missions and here on Earth. National Aeronautics and Space Administration (NASA) crewmembers have a 4.3 times higher risk of herniated IVDs, compared with the general and military aviator populations. The highest risk occurs during the first year after a mission. Microgravity exposure during long-duration spaceflights results in approximately 5 cm lengthening of body height, spinal pain, and skeletal deconditioning. How the PSMs and IVDs respond during spaceflight is not well described. Six NASA crewmembers were imaged supine with a 3 Tesla magnetic resonance imaging. Imaging was conducted preflight, immediately postflight, and then 33 to 67 days after landing. Functional cross-sectional area (FCSA) measurements of the PSMs were performed at the L3-4 level. FCSA was measured by grayscale thresholding within the posterior lumbar extensors to isolate lean muscle on T2-weighted scans. IVD heights were measured at the anterior, middle, and posterior sections of all lumbar levels. Repeated measures analysis of variance was used to determine significance at P < 0.05, followed by post-hoc testing. Paraspinal lean muscle mass, as indicated by the FCSA, decreased from 86% of the total PSM cross-sectional area down to 72%, immediately after the mission. Recovery of 68% of the postflight loss occurred during the next 6 weeks, still leaving a significantly lower lean muscle fractional content compared with preflight values. In contrast, lumbar IVD heights were not appreciably different at any time point. The data reveal lumbar spine PSM atrophy after long-duration spaceflight. Some FCSA recovery was seen with 46 days postflight in a terrestrial environment, but it

  8. Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice

    Directory of Open Access Journals (Sweden)

    Shoji Hirotaka

    2012-02-01

    Full Text Available Abstract Background Disrupted-in-Schizophrenia 1 (DISC1 is considered to be a candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. A recent study reported that N-ethyl-N-nitrosourea (ENU-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice; thus, these are potential animal models of psychiatric disorders. However, remaining heterozygous mutations that possibly occur in flanking genes other than Disc1 itself might induce behavioral abnormalities in the mutant mice. Here, to confirm the effects of Disc1-Q31L and Disc1-L100P mutations on behavioral phenotypes and to investigate the behaviors of the mutant mice in more detail, the mutant lines were backcrossed to C57BL/6JJcl through an additional two generations and the behaviors were analyzed using a comprehensive behavioral test battery. Results Contrary to expectations, 31 L mutant mice showed no significant behavioral differences when compared with wild-type control mice in any of the behavioral tests, including the Porsolt forced swim and tail suspension tests, commonly used tests for depression-like behavior. Also, 100P mutant mice exhibited no differences in almost all of the behavioral tests, including the prepulse inhibition test for measuring sensorimotor gating, which is known to be impaired in schizophrenia patients; however, 100P mutant mice showed higher locomotor activity compared with wild-type control mice in the light/dark transition test. Conclusions Although these results are partially consistent with the previous study in that there was hyperactivity in 100P mutant mice, the vast majority of the results are inconsistent with those of the previous study; this discrepancy may be explained by differences in the genetic background of the

  9. Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.

    Science.gov (United States)

    Shoji, Hirotaka; Toyama, Keiko; Takamiya, Yoshihiro; Wakana, Shigeharu; Gondo, Yoichi; Miyakawa, Tsuyoshi

    2012-02-20

    Disrupted-in-Schizophrenia 1 (DISC1) is considered to be a candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. A recent study reported that N-ethyl-N-nitrosourea (ENU)-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice; thus, these are potential animal models of psychiatric disorders. However, remaining heterozygous mutations that possibly occur in flanking genes other than Disc1 itself might induce behavioral abnormalities in the mutant mice. Here, to confirm the effects of Disc1-Q31L and Disc1-L100P mutations on behavioral phenotypes and to investigate the behaviors of the mutant mice in more detail, the mutant lines were backcrossed to C57BL/6JJcl through an additional two generations and the behaviors were analyzed using a comprehensive behavioral test battery. Contrary to expectations, 31 L mutant mice showed no significant behavioral differences when compared with wild-type control mice in any of the behavioral tests, including the Porsolt forced swim and tail suspension tests, commonly used tests for depression-like behavior. Also, 100P mutant mice exhibited no differences in almost all of the behavioral tests, including the prepulse inhibition test for measuring sensorimotor gating, which is known to be impaired in schizophrenia patients; however, 100P mutant mice showed higher locomotor activity compared with wild-type control mice in the light/dark transition test. Although these results are partially consistent with the previous study in that there was hyperactivity in 100P mutant mice, the vast majority of the results are inconsistent with those of the previous study; this discrepancy may be explained by differences in the genetic background of the mice, the laboratory environment, experimental protocols

  10. Antiurolithiatic Activity of Extract and Oleanolic Acid Isolated from the Roots of Lantana camara on Zinc Disc Implantation Induced Urolithiasis.

    Science.gov (United States)

    Vyas, Narendra; Argal, Ameeta

    2013-01-01

    The present study was done to evaluate the antiurolithiatic activity of ethanolic extract of roots (ELC 200 mg/kg) and oleanolic acid (OA 60 mg/kg, O.A. 80 mg/kg, O.A. 100 mg/kg) isolated from roots of Lantana camara in albino wistar male rats using zinc disc implantation induced urolithiatic model. The group in which only zinc disc was implanted without any treatment showed increase in calcium output (23  ± 2.7 mg/dL). Cystone receiving animals showed significant protection from such change (P urolitiasis. Thus, OA and ELC showed promising antiurolithiatic activity in dose dependant manner.

  11. Constitutive model for flake graphite cast iron automotive brake discs: induced anisotropic damage model under complex loadings

    Science.gov (United States)

    Augustins, L.; Billardon, R.; Hild, F.

    2016-09-01

    The present paper details an elasto-viscoplastic constitutive model for automotive brake discs made of flake graphite cast iron. In a companion paper (Augustins et al. in Contin Mech Thermodyn, 2015), the authors proposed a one-dimensional setting appropriate for representing the complex behavior of the material (i.e., asymmetry between tensile and compressive loadings) under anisothermal conditions. The generalization of this 1D model to 3D cases on a volume element and the associated challenges are addressed. A direct transposition is not possible, and an alternative solution without unilateral conditions is first proposed. Induced anisotropic damage and associated constitutive laws are then introduced. The transition from the volume element to the real structure and the numerical implementation require a specific basis change. Brake disc simulations with this constitutive model show that unilateral conditions are needed for the friction bands. A damage deactivation procedure is therefore defined.

  12. In vitro assessment of biomaterial-induced remodeling of subchondral and cancellous bone for the early intervention of joint degeneration with focus on the spinal disc

    Science.gov (United States)

    McCanless, Jonathan D.

    Osteoarthritis-associated pain of the spinal disc, knee, and hip derives from degeneration of cartilagenous tissues in these joints. Traditional therapies have focused on these cartilage (and disc specific nucleus pulposus) changes as a means of treatment through tissue grafting, regenerative synthetic implants, non-regenerative space filling implants, arthroplasty, and arthrodesis. Although such approaches may seem apparent upon initial consideration of joint degeneration, tissue pathology has shown changes in the underlying bone and vascular bed precede the onset of cartilaginous changes. It is hypothesized that these changes precedent joint degeneration and as such may provide a route for early prevention. The current work proposes an injectable biomaterial-based therapy within these subchondral and cancellous bone regions as a means of preventing or reversing osteoarthritis. Two human concentrated platelet releasate-containing alginate hydrogel/beta-tricalcium phosphate composites have been developed for this potential biomaterial application. The undertaking of assessing these materials through bench-, in vitro, and ex vivo work is described herein. These studies showed the capability of the biomaterials to initiate a wound healing response in monocytes, angiogenic and differentiation behavior in immature endothelial cells, and early osteochondral differentiation in mesenchymal stem cells. These cellular activities are associated with fracture healing and endochondral bone formation, demonstrating the potential of the biomaterials to induce osseous and vascular tissue remodeling underlying osteoarthritic joints as a novel therapy for a disease with rapidly growing healthcare costs.

  13. Vortex formation in protoplanetary discs induced by the vertical shear instability

    CERN Document Server

    Richard, Samuel; Umurhan, Orkan M

    2016-01-01

    We present the results of 2D and 3D hydrodynamic simulations of idealized protoplanetary discs that examine the formation and evolution of vortices by the vertical shear instability (VSI). In agreement with recent work, we find that discs with radially decreasing temperature profiles and short thermal relaxation time-scales, are subject to the axisymmetric VSI. In three dimensions, the resulting velocity perturbations give rise to quasi-axisymmetric potential vorticity perturbations that break-up into discrete vortices, in a manner that is reminiscent of the Rossby wave instability. Discs with very short thermal evolution time-scales (i.e. {\\tau}<0.1 local orbit periods) develop strong vorticity perturbations that roll up into vortices that have small aspect ratios ({\\chi}<2) and short lifetimes (~ a few orbits). Longer thermal time-scales give rise to vortices with larger aspect ratios (6<{\\chi}<10), and lifetimes that depend on the entropy gradient. A steeply decreasing entropy profile leads to ...

  14. Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine.

    Science.gov (United States)

    Liang, Qian-Qian; Zhou, Quan; Zhang, Min; Hou, Wei; Cui, Xue-Jun; Li, Chen-Guang; Li, Tian-Fang; Shi, Qi; Wang, Yong-Jun

    2008-09-01

    Both forelimbs of rats were amputated, and these rats were kept in the custom-made cages that kept the rats in prolonged upright posture. Pathologic changes were observed in the lumbar spine at different time points after the surgery. To investigate the effect of upright posture on intervertebral discs of rat lumbar spine. Previous studies have shown that increased axial forces on the spine can decrease the height of the intervertebral disc, but there are no data to indicate whether or not long-term and repeated assumption of the upright posture could result in degenerative changes. The forelimbs of 30 rats were amputated when they were 1-month old. These rats were kept in the custom-made cages and were forced to stand upright on their hind-limbs and tails to obtain water and food. Normal rats of the same ages kept in regular cages were used as control. The rats were killed at 5, 7, and 9 months after the surgery, and the intervertebral discs samples of lumbar spine were harvested for histologic and immunohistochemical studies. Total RNA isolated from these samples was used for real-time PCR of type II collagen (Col2alpha1), type X collagen (Col10alpha1), matrix metalloproteinase-13 (MMP-13), aggrecan, and disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5). RESULTS.: Histologic analysis showed degenerative changes of the intervertebral discs after surgery such as disordered collagen structure of endplate cartilage, fragmentation of annulus fibrosus, and decreased height of disc. Immunostaining revealed decreased protein level of type II collagen and increased protein expression of type X collagen. Real-time PCR showed upregulated expression of MMP 13, ADAMTS-5, and Col10alpha1 mRNA and downregulated mRNA expression of Col2alpha1 and aggrecan. Long-term and repeated assumption of the upright stance accelerates disc degeneration in rats.

  15. Laser-induced activation of regeneration processes in spine disc cartilage

    Science.gov (United States)

    Sobol, Emil N.; Vorobjeva, Natalia N.; Sviridov, Alexander P.; Omelchenko, Alexander I.; Baskov, Andrey V.; Shekhter, Anatoliy B.; Baskov, Vladimir A.; Feldchtein, Felix I.; Kamensky, Vladislav A.; Kuranov, Roman V.

    2000-05-01

    The effect of laser radiation on the regeneration processes in spine disk cartilage has been studied in-vivo. We used rabbits as a model and a Holmium (2.09 micrometer) and an Erbium fiber (1.56 micrometer) lasers for irradiation the discs which were preliminary opened to remove annulus fibrosus and the nucleus pulposus of the intervertebral disc. The irradiated zone has been examined using an optical coherent tomography in one month after the operation and conventional histological technique in two months after the laser operation. It has been shown that laser radiation promotes the growth of the new cartilaginous tissue of fibrous and hyaline types.

  16. Tracing Planets in Circumstellar Discs

    Directory of Open Access Journals (Sweden)

    Uribe Ana L.

    2013-04-01

    Full Text Available Planets are assumed to form in circumstellar discs around young stellar objects. The additional gravitational potential of a planet perturbs the disc and leads to characteristic structures, i.e. spiral waves and gaps, in the disc density profile. We perform a large-scale parameter study on the observability of these planet-induced structures in circumstellar discs in the (submm wavelength range for the Atacama Large (SubMillimeter Array (ALMA. On the basis of hydrodynamical and magneto-hydrodynamical simulations of star-disc-planet models we calculate the disc temperature structure and (submm images of these systems. These are used to derive simulated ALMA maps. Because appropriate objects are frequent in the Taurus-Auriga region, we focus on a distance of 140 pc and a declination of ≈ 20°. The explored range of star-disc-planet configurations consists of six hydrodynamical simulations (including magnetic fields and different planet masses, nine disc sizes with outer radii ranging from 9 AU to 225 AU, 15 total disc masses in the range between 2.67·10-7 M⊙ and 4.10·10-2 M⊙, six different central stars and two different grain size distributions, resulting in 10 000 disc models. At almost all scales and in particular down to a scale of a few AU, ALMA is able to trace disc structures induced by planet-disc interaction or the influence of magnetic fields in the wavelength range between 0.4...2.0 mm. In most cases, the optimum angular resolution is limited by the sensitivity of ALMA. However, within the range of typical masses of protoplane tary discs (0.1 M⊙...0.001 M⊙ the disc mass has a minor impact on the observability. At the distance of 140 pc it is possible to resolve discs down to 2.67·10-6 M⊙ and trace gaps in discs with 2.67·10-4 M⊙ with a signal-to-noise ratio greater than three. In general, it is more likely to trace planet-induced gaps in magneto-hydrodynamical disc models, because gaps are wider in the presence of

  17. How do accretion discs break?

    Science.gov (United States)

    Dogan, Suzan

    2016-07-01

    Accretion discs are common in binary systems, and they are often found to be misaligned with respect to the binary orbit. The gravitational torque from a companion induces nodal precession in misaligned disc orbits. In this study, we first calculate whether this precession is strong enough to overcome the internal disc torques communicating angular momentum. We compare the disc precession torque with the disc viscous torque to determine whether the disc should warp or break. For typical parameters precession wins: the disc breaks into distinct planes that precess effectively independently. To check our analytical findings, we perform 3D hydrodynamical numerical simulations using the PHANTOM smoothed particle hydrodynamics code, and confirm that disc breaking is widespread and enhances accretion on to the central object. For some inclinations, the disc goes through strong Kozai cycles. Disc breaking promotes markedly enhanced and variable accretion and potentially produces high-energy particles or radiation through shocks. This would have significant implications for all binary systems: e.g. accretion outbursts in X-ray binaries and fuelling supermassive black hole (SMBH) binaries. The behaviour we have discussed in this work is relevant to a variety of astrophysical systems, for example X-ray binaries, where the disc plane may be tilted by radiation warping, SMBH binaries, where accretion of misaligned gas can create effectively random inclinations and protostellar binaries, where a disc may be misaligned by a variety of effects such as binary capture/exchange, accretion after binary formation.

  18. Periprosthetic UHMWPE Wear Debris Induces Inflammation, Vascularization, and Innervation After Total Disc Replacement in the Lumbar Spine.

    Science.gov (United States)

    Veruva, Sai Y; Lanman, Todd H; Isaza, Jorge E; Freeman, Theresa A; Kurtz, Steven M; Steinbeck, Marla J

    2017-05-01

    The pathophysiology and mechanisms driving the generation of unintended pain after total disc replacement (TDR) remain unexplored. Ultrahigh-molecular-weight polyethylene (UHMWPE) wear debris from TDRs is known to induce inflammation, which may result in pain. The purpose of this study was to determine whether (1) periprosthetic UHMWPE wear debris induces immune responses that lead to the production of tumor necrosis factor-α (TNFα) and interleukin (IL)-1ß, the vascularization factors, vascular endothelial growth factor (VEGF) and platelet-derived growth factor-bb (PDGFbb), and the innervation/pain factors, nerve growth factor (NGF) and substance P; (2) the number of macrophages is associated with the production of the aforementioned factors; (3) the wear debris-induced inflammatory pathogenesis involves an increase in vascularization and associated innervation. Periprosthetic tissues from our collection of 11 patients with contemporary TDRs were evaluated using polarized light microscopy to quantify UHMWPE wear particles. The major reason for revision (mean implantation time of 3 years [range, 1-6 years]) was pain. For control subjects, biopsy samples from four patients with degenerative disc disease with severe pain and autopsy samples from three normal patients with no history of back pain were also investigated. Immunohistochemistry and histology were used to identify secretory factors, macrophages, and blood vessels. Immunostained serial sections were imaged at ×200 magnification and using MATLAB and NIH ImageJ, a threshold was determined for each factor and used to quantify positive staining normalized to tissue sectional area. The Mann-Whitney U test was used to compare results from different patient groups, whereas the Spearman Rho test was used to determine correlations. Significance was based on p < 0.05. The mean percent area of all six inflammatory, vascularization, and innervation factors was higher in TDR tissues when compared with normal disc

  19. Intersex (ix) mutations of Drosophila melanogaster cause nonrandom cell death in genital disc and can induce tumours in genitals in response to decapentaplegic (dppdisk) mutations

    Indian Academy of Sciences (India)

    R. N. chatterjee; P. Chatterjee; S. Kuthe; M. Acharyya-Ari; R. Chatterjee

    2015-06-01

    In Drosophila melanogaster, the intersex (ix) is a terminally positioned gene in somatic sex determination hierarchy and function with the female specific product of double sex (DSXF) to implement female sexual differentiation. The null phenotype of ix is to transform diplo-X individuals into intersexes while leaving haplo-X animals unaffected. This study on the effect of different intersex mutations on genital disc development provides the following major results: (i) similar range of a characteristic array of morphological structures (from almost double sex terminalia to extreme reduction of terminal appendages) was displayed by the terminalia of XX ix1/ix1, XX ix2/ix2 and XX ix5/ix5 individuals; (ii) an increased number of apoptotic cells were found to occur in a localized manner in mature third instar larval genital discs of ix individuals; (iii) ix mutations can induce high frequency of neoplastic tumours in genitals in the presence of decapentaplegic (dppdisk) mutations; and (iv) heteroallelic combinations of dppdisk mutations can also induce tumours in intersex genitals with variable expressivity. On the basis of these findings, we suggest that: (i) loss of function of ix causes massive cell death in both male and female genital primordia of genital discs, resulting phenotype mimicking in male and female characteristics in genitals; and (ii) at the discs, the apoptotic cells persist as ‘undead’ cells that can induce oncogenic transformation in the neighbouring disc cells when dpp signalling is blocked or reduced by dppdisk mutations.

  20. Estrogens and the intervertebral disc.

    Science.gov (United States)

    Calleja-Agius, J; Muscat-Baron, Y; Brincat, M P

    2009-09-01

    Intervertebral discs are an integral part of the vertebral column. It has been shown that menopause has a negative effect on bone and on intervertebral discs. Estrogen has a beneficial effect of preserving the health of collagen-containing tissues, including the intervertebral disc. The intervertebral disc allows for mobility of the spine, and maintains a uniform stress distribution of the area of the vertebral endplates. Also, the disc influences spinal height. The disc tissue is adapted for this biomechanical function. The function of the spine is impaired if there is a loss of disc tissue. Narrowing of the disc space due to degeneration of intervertebral discs is associated with a significantly increased risk of vertebral fractures. Estrogen should be seen as the first-choice therapy for bones and other collagen-rich tissues, such as intervertebral discs, because it maintains homeostasis of the bone-remodelling unit. Unlike bisphosphonates, estrogen is unique in its ability to regenerate bone collagen after its disintegration, apart from suppressing osteoclastic activity. Besides, there is insufficient data on deterioration in bone qualities and micro-cracks in patients on long-term bisphosphonates.

  1. Lumbar disc protrusion therapy by combination drug administration in epidural space%硬膜外腔联合用药治疗腰椎间盘突出症

    Institute of Scientific and Technical Information of China (English)

    尹美华; 杨德荣; 许晶; 马玉清

    2003-01-01

    @@ BACKGROUND: Lumbar disc protrusion was a syndrome dueto degeneration of disc, disruption of fibrous tings and protrusion ofnucleus pulposus and stimulation of cauda equina. It was the mostcommon cause of leg and back pain. it had a high incidence rate andthe patients suffered too greatly to normal work and life. Afternon-operative therapy, symptoms of most patients disappeared orrelieved. Only 10% to 15% of the patients needed operation. Re-cently, combination drug administration in epidural space were usedin lumbar disc protrusion therapy with a highly successful rate andhttle danger.

  2. Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats.

    Science.gov (United States)

    Liang, Qian-Qian; Xi, Zhi-Jie; Bian, Qin; Cui, Xue-Jun; Li, Chen-Guang; Hou, Wei; Shi, Qi; Wang, Yong-Jun

    2010-01-01

    Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

  3. Radiation induced conductivity in space dielectric materials

    Science.gov (United States)

    Hanna, R.; Paulmier, T.; Molinie, P.; Belhaj, M.; Dirassen, B.; Payan, D.; Balcon, N.

    2014-01-01

    The radiation-induced conductivity of some polymers was described mainly in literature by a competition between ionization, trapping/detrapping, and recombination processes or by radiation assisted ageing mechanisms. Our aim is to revise the effect of the aforementioned mechanisms on the complex evolution of Teflon® FEP under space representative ionizing radiation. Through the definition of a new experimental protocol, revealing the effect of radiation dose and relaxation time, we have been able to demonstrate that the trapping/recombination model devised in this study agrees correctly with the observed experimental phenomenology at qualitative level and allows describing very well the evolution of radiation induced conductivity with irradiation time (or received radiation dose). According to this model, the complex behavior observed on Teflon® FEP may be basically ascribed to the competition between electron/hole pairs generation and recombination: electrons are deeply trapped and act as recombination centers for free holes. Relaxation effects have been characterized through successive irradiations steps and have been again well described with the defined model at qualitative level: recombination centers created by the irradiation induce long term alteration on the electric properties, especially the effective bulk conductivity. One-month relaxation does not allow a complete recovery of the material initial charging behavior.

  4. Radiation induced conductivity in space dielectric materials

    Energy Technology Data Exchange (ETDEWEB)

    Hanna, R. [DESP, The French Aerospace Lab, 2 avenue Edouard Belin, 31055 Toulouse (France); Energie, SUPELEC, 3 rue Joliot Curie, 91192 Gif sur Yvette (France); CNES, 18 avenue Edouard Belin, 31401 Toulouse (France); Paulmier, T., E-mail: thierry.paulmier@onera.fr; Belhaj, M.; Dirassen, B. [DESP, The French Aerospace Lab, 2 avenue Edouard Belin, 31055 Toulouse (France); Molinie, P. [Energie, SUPELEC, 3 rue Joliot Curie, 91192 Gif sur Yvette (France); Payan, D.; Balcon, N. [CNES, 18 avenue Edouard Belin, 31401 Toulouse (France)

    2014-01-21

    The radiation-induced conductivity of some polymers was described mainly in literature by a competition between ionization, trapping/detrapping, and recombination processes or by radiation assisted ageing mechanisms. Our aim is to revise the effect of the aforementioned mechanisms on the complex evolution of Teflon{sup ®} FEP under space representative ionizing radiation. Through the definition of a new experimental protocol, revealing the effect of radiation dose and relaxation time, we have been able to demonstrate that the trapping/recombination model devised in this study agrees correctly with the observed experimental phenomenology at qualitative level and allows describing very well the evolution of radiation induced conductivity with irradiation time (or received radiation dose). According to this model, the complex behavior observed on Teflon{sup ®} FEP may be basically ascribed to the competition between electron/hole pairs generation and recombination: electrons are deeply trapped and act as recombination centers for free holes. Relaxation effects have been characterized through successive irradiations steps and have been again well described with the defined model at qualitative level: recombination centers created by the irradiation induce long term alteration on the electric properties, especially the effective bulk conductivity. One-month relaxation does not allow a complete recovery of the material initial charging behavior.

  5. Space Flight-Induced Intracranial Hypertension: An Ophthalmic Review

    Science.gov (United States)

    Gibson, Charles Robert; Mader, Thomas H.

    2010-01-01

    Background: Although physiologic and pathologic changes associated with microgravity exposure have been studied extensively, the effect of this environment on the eye is largely unknown. Over the last several years, NASA s Space Medicine Division has documented astronauts presenting with varying degrees of disc edema, globe flattening, choroidal folds, cotton wool spots, and hyperopic shifts after long-duration space flight. Methods: Before and after long-duration space flight, six astronauts underwent complete eye examinations to include cycloplegic and/or manifest refraction and fundus photography. Five of these astronauts had Optical Coherence Tomography (OCT) and Magnetic Resonance Imaging (MRI) performed following their missions. Results: Following exposure to space flight of approximately 6-months duration, six astronauts had neuro-ophthalmic findings. These consisted of disc edema in four astronauts, globe flattening in four astronauts, choroidal folds in four astronauts, cotton wool spots in three astronauts, nerve fiber layer thickening by OCT in five astronauts, and decreased near vision in five astronauts. Four of the astronauts with near vision complaints had a hyperopic shift equal to or greater than + 0.50D between pre- and post-mission spherical equivalent refraction in one or both eyes (range +0.50D to +1.50D). These same four had globe flattening by MRI. Conclusions: The findings we describe may have resulted from a rise in intracranial pressure caused by microgravity fluid shifts, and could represent parts of a spectrum of ocular and cerebral responses to extended microgravity.

  6. Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs.

    Science.gov (United States)

    Zhu, Jun; Tang, Haoyu; Zhang, Zhenhua; Zhang, Yong; Qiu, Chengfeng; Zhang, Ling; Huang, Pinge; Li, Feng

    2017-02-01

    Intervertebral disc (IVD) degeneration is a common disease that represents a significant cause of socio-economic problems. Bone marrow-derived mesenchymal stem cells (BMSCs) are a potential autologous stem cell source for the nucleus pulposus regeneration. Kaempferol has been reported to exert protective effects against both osteoporosis and obesity. This study explored the effect of kaempferol on BMSCs differentiation and inflammation. The results demonstrated that kaempferol did not show any cytotoxicity at concentrations of 20, 60 and 100μM. Kaempferol enhanced cell viability by counteracting the lipopolysaccharide (LPS)-induced cell apoptosis and increasing cell proliferation. Western blot analysis of mitosis-associated nuclear antigen (Ki67) and proliferation cell nuclear antigen (PCNA) further confirmed the increased effect of kaempferol on LPS-induced decreased viability of BMSCs. Besides, kaempferol elevated LPS-induced reduced level of chondrogenic markers (SOX-9, Collagen II and Aggrecan), decreased the level of matrix-degrading enzymes, i.e., matrix metalloprotease (MMP)-3 and MMP-13, suggesting the osteogenesis of BMSC under kaempferol treatment. On the other hand, kaempferol enhanced LPS-induced decreased expression of lipid catabolism-related genes, i.e., carnitine palmitoyl transferase-1 (CPT-1). Kaempferol also suppressed the expression of lipid anabolism-related genes, i.e., peroxisome proliferators-activated receptor-γ (PPAR-γ). The Oil red O staining further convinced the inhibition effect of kaempferol on BMSCs adipogenesis. In addition, kaempferol alleviated inflammatory by reducing the level of pro-inflammatory cytokines (i.e., interleukin (IL)-6) and increasing anti-inflammatory cytokine (IL-10) via inhibiting the nucleus translocation of nuclear transcription factor (NF)-κB p65. Taken together, our research indicated that kaempferol may serve as a novel target for treatment of IVD degeneration.

  7. PGE1 Attenuates IL-1β-induced NGF Expression in Human Intervertebral Disc Cells.

    Science.gov (United States)

    Murata, Kazuma; Sawaji, Yasunobu; Alimasi, Wuqikun; Suzuki, Hidekazu; Endo, Kenji; Tanaka, Hidetoshi; Yorifuji, Makiko; Kosaka, Taiichi; Shishido, Takaaki; Yamamoto, Kengo

    2016-06-01

    In vitro study using isolated human intervertebral disc (IVD) cells. To investigate the effects of prostaglandin (PG)E1 and its orally available derivative limaprost on the regulation of nerve growth factor (NGF) expression and to compare their actions with other prostanoids using interleukin (IL)-1-stimulated human IVD cells. We previously reported that a selective COX-2 inhibitor enhanced, whereas PGE2 suppressed the induction of NGF by IL-1 in human IVD cells, and proposed that PGE2 can suppress NGF expression by a negative feedback mechanism. Isolated human IVD cells were stimulated with IL-1 in the presence or absence of increasing concentrations of PGE2, PGE1, limaprost, PGI2, PGD2, or PGF2α (10-10,000 nM). For some experiments, an E-series prostanoid receptor (EP)4 antagonist (L-161,982) was added prior to the stimulation. NGF expression was determined by real-time polymerase chain reaction and its protein level was quantified by enzyme-linked immunosorbent assay. PGE2, PGE1, and limaprost inhibited the IL-1-mediated induction of NGF in a concentration-dependent manner, with IC50 values of 9.9, 10.6, and 70.9 nM, respectively. PGI2 also suppressed NGF expression but to a much less extent. PGD2, on the other hand, significantly enhanced NGF expression, whereas PGF2α had no effect. Protein expression levels of NGF mirrored its mRNA levels. The suppression of NGF expression by PGE2 and PGE1 was partly reversed by L-161,982. PGE1 and limaprost exhibited a novel pharmacological action that suppresses NGF expression in human IVD cells, and other prostanoids differentially regulated NGF expression. Limaprost has been used to treat patients with lumbar spinal stenosis in Japan and was proved to be effective in relieving symptoms. Our in vitro results may explain, in part, the mechanism of action of limaprost for low back pain. N/A.

  8. Generation of highly inclined protoplanetary discs through single stellar flybys

    CERN Document Server

    Xiang-Gruess, Meng

    2015-01-01

    We study the three-dimensional evolution of a viscous protoplanetary disc which is perturbed by a passing star on a parabolic orbit. The aim is to test whether a single stellar flyby is capable to excite significant disc inclinations which would favour the formation of so-called misaligned planets. We use smoothed particle hydrodynamics to study inclination, disc mass and angular momentum changes of the disc for passing stars with different masses. We explore different orbital configurations for the perturber's orbit to find the parameter spaces which allow significant disc inclination generation. Prograde inclined parabolic orbits are most destructive leading to significant disc mass and angular momentum loss. In the remaining disc, the final disc inclination is only below $20^\\circ$. This is due to the removal of disc particles which have experienced the strongest perturbing effects. Retrograde inclined parabolic orbits are less destructive and can generate disc inclinations up to $60^\\circ$. The final disc...

  9. Accretion discs trapped near corotation

    OpenAIRE

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states over a wide range of parameter space. We find two distinct regions of instability: one related to the buildup and release of mass in the disc outside corotation, and the other to mass storage with...

  10. Optical methods for diagnostics and feedback control in laser-induced regeneration of spine disc and joint cartilages

    Science.gov (United States)

    Sobol, Emil; Sviridov, Alexander; Omeltchenko, Alexander; Baum, Olga; Baskov, Andrey; Borchshenko, Igor; Golubev, Vladimir; Baskov, Vladimir

    2011-03-01

    In 1999 we have introduced a new approach for treatment of spine diseases based on the mechanical effect of nondestructive laser radiation on the nucleus pulposus of the intervertebral disc. Laser reconstruction of spine discs (LRD) involves puncture of the disc and non-destructive laser irradiation of the nucleus pulposus to activate reparative processes in the disc tissues. In vivo animal study has shown that LRD allows activate the growth of hyaline type cartilage in laser affected zone. The paper considers physical processes and mechanisms of laser regeneration, presents results of investigations aimed to optimize laser settings and to develop feedback control system for laser reparation in cartilages of spine and joints. The results of laser reconstruction of intervertebral discs for 510 patients have shown substantial relief of back pain for 90% of patients. Laser technology has been experimentally tested for reparation of traumatic and degenerative diseases in joint cartilage of 20 minipigs. It is shown that laser regeneration of cartilage allows feeling large (more than 5 mm) defects which usually never repair on one's own. Optical techniques have been used to promote safety and efficacy of the laser procedures.

  11. Space travel directly induces skeletal muscle atrophy

    Science.gov (United States)

    Vandenburgh, H.; Chromiak, J.; Shansky, J.; Del Tatto, M.; Lemaire, J.

    1999-01-01

    Space travel causes rapid and pronounced skeletal muscle wasting in humans that reduces their long-term flight capabilities. To develop effective countermeasures, the basis of this atrophy needs to be better understood. Space travel may cause muscle atrophy indirectly by altering circulating levels of factors such as growth hormone, glucocorticoids, and anabolic steroids and/or by a direct effect on the muscle fibers themselves. To determine whether skeletal muscle cells are directly affected by space travel, tissue-cultured avian skeletal muscle cells were tissue engineered into bioartificial muscles and flown in perfusion bioreactors for 9 to 10 days aboard the Space Transportation System (STS, i.e., Space Shuttle). Significant muscle fiber atrophy occurred due to a decrease in protein synthesis rates without alterations in protein degradation. Return of the muscle cells to Earth stimulated protein synthesis rates of both muscle-specific and extracellular matrix proteins relative to ground controls. These results show for the first time that skeletal muscle fibers are directly responsive to space travel and should be a target for countermeasure development.

  12. Space travel directly induces skeletal muscle atrophy

    Science.gov (United States)

    Vandenburgh, H.; Chromiak, J.; Shansky, J.; Del Tatto, M.; Lemaire, J.

    1999-01-01

    Space travel causes rapid and pronounced skeletal muscle wasting in humans that reduces their long-term flight capabilities. To develop effective countermeasures, the basis of this atrophy needs to be better understood. Space travel may cause muscle atrophy indirectly by altering circulating levels of factors such as growth hormone, glucocorticoids, and anabolic steroids and/or by a direct effect on the muscle fibers themselves. To determine whether skeletal muscle cells are directly affected by space travel, tissue-cultured avian skeletal muscle cells were tissue engineered into bioartificial muscles and flown in perfusion bioreactors for 9 to 10 days aboard the Space Transportation System (STS, i.e., Space Shuttle). Significant muscle fiber atrophy occurred due to a decrease in protein synthesis rates without alterations in protein degradation. Return of the muscle cells to Earth stimulated protein synthesis rates of both muscle-specific and extracellular matrix proteins relative to ground controls. These results show for the first time that skeletal muscle fibers are directly responsive to space travel and should be a target for countermeasure development.

  13. Extremely High Suction Performance Inducers for Space Propulsion Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation provides a way to design low flow coefficient inducers that have higher cavitation breakdown margin, larger blade angles, thicker more...

  14. Extremely High Suction Performance Inducers for Space Propulsion Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced pump inducer design technology that uses high inlet diffusion blades, operates at a very low flow coefficient, and employs a cavitation control and...

  15. Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss

    Science.gov (United States)

    LeBlanc, Adrian; Matsumoto, Toshio; Jones, Jeff; Shapiro, Jay; Lang, Tom; Smith, Scott M.; Shackelford, Linda C.; Sibonga, Jean; Evans, Harlan; Spector, Elisabeth; hide

    2011-01-01

    Experiment Hypothesis -- The combined effect of anti-resorptive drugs plus in-flight exercise regimen will have a measurable effect in preventing space flight induced bone mass and strength loss and reducing renal stone risk.

  16. Broken discs: warp propagation in accretion discs

    OpenAIRE

    Nixon, Chris; King, Andrew

    2012-01-01

    We simulate the viscous evolution of an accretion disc around a spinning black hole. In general any such disc is misaligned, and warped by the Lense-Thirring effect. Unlike previous studies we use effective viscosities constrained to be consistent with the internal fluid dynamics of the disc. We find that nonlinear fluid effects, which reduce the effective viscosities in warped regions, can promote the breaking of the disc into two distinct planes. This occurs when the Shakura & Sunyaev dimen...

  17. Total disc replacement.

    Science.gov (United States)

    Vital, J-M; Boissière, L

    2014-02-01

    Total disc replacement (TDR) (partial disc replacement will not be described) has been used in the lumbar spine since the 1980s, and more recently in the cervical spine. Although the biomechanical concepts are the same and both are inserted through an anterior approach, lumbar TDR is conventionally indicated for chronic low back pain, whereas cervical TDR is used for soft discal hernia resulting in cervicobrachial neuralgia. The insertion technique must be rigorous, with precise centering in the disc space, taking account of vascular anatomy, which is more complex in the lumbar region, particularly proximally to L5-S1. All of the numerous studies, including prospective randomized comparative trials, have demonstrated non-inferiority to fusion, or even short-term superiority regarding speed of improvement. The main implant-related complication is bridging heterotopic ossification with resulting loss of range of motion and increased rates of adjacent segment degeneration, although with an incidence lower than after arthrodesis. A sufficiently long follow-up, which has not yet been reached, will be necessary to establish definitively an advantage for TDR, particularly in the cervical spine. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  18. Induced measures in the space of mixed quantum states

    Energy Technology Data Exchange (ETDEWEB)

    Zyczkowski, Karol [Centrum Fizyki Teoretycznej, Polska Akademia Nauk, Warsaw, Poland and Instytut Fizyki, Uniwersytet Jagiellonski, Crakow (Poland)). E-mail: karol@cft.edu.pl; Sommers, Hans-Juergen [Fachbereich Physik, Universitaet-Gesamthochschule Essen, Essen (Germany)). E-mail: sommers@next30.theo-phys.uni-essen.de

    2001-09-07

    We analyse several product measures in the space of mixed quantum states. In particular, we study measures induced by the operation of partial tracing. The natural, rotationally invariant measure on the set of all pure states of a NxK composite system, induces a unique measure in the space of NxN mixed states (or in the space of KxK mixed states, if the reduction takes place with respect to the first subsystem). For K=N the induced measure is equal to the Hilbert-Schmidt measure, which is shown to coincide with the measure induced by singular values of non-Hermitian random Gaussian matrices pertaining to the Ginibre ensemble. We compute several averages with respect to this measure and show that the mean entanglement of NxN pure states behaves as lnN-1/2. (author)

  19. Induced measures in the space of mixed quantum states

    CERN Document Server

    Zyczkowski, K; Zyczkowski, Karol; Sommers, Hans-Juergen

    2001-01-01

    We analyze several product measures in the space of mixed quantum states. In particular we study measures induced by the operation of partial tracing. The natural, rotationally invariant measure on the set of all pure states of a N x K composite system, induces a unique measure in the space of N x N mixed states (or in the space of K x K mixed states, if the reduction takes place with respect to the first subsystem). For K=N the induced measure is equal to the Hilbert-Schmidt measure, which is shown to coincide with the measure induced by singular values of non-Hermitian random Gaussian matrices pertaining to the Ginibre ensemble. We compute several averages with respect to this measure and show that the mean entanglement of $N \\times N$ pure states behaves as lnN-1/2.

  20. A model to assess the efficacy of moisturizers--the quantification of soap-induced xerosis by image analysis of adhesive-coated discs (D-Squames).

    Science.gov (United States)

    El Gammal, C; Pagnoni, A; Kligman, A M; el Gammal, S

    1996-09-01

    Clinical grading of dry skin syndromes (xerosis) is beset by many variables which limit its reliability. Removing scales onto adhesive coated discs (D-Squames) has provided a means for objective measurement of xerotic states. Using image analysis we have modified the basic procedure to assure greater accuracy and reproducibility. The distribution of grey values on the discs was determined, from which a single value of the degree of scaling was calculated. We term this the scaling index. To induce xerosis, the lower legs of 22 women, aged 26-64, were washed daily for 10 days with soap. After washing, one side received a moisturizing lotion, the other served as an untreated control. At specified intervals, scaling was graded clinically, electrical conductance was measured and D-Squames were obtained. On the moisturizer-treated legs there was a significant decrease in dryness grades and scaling indices at all time points. Conductance was significantly increased on days 8 and 11. The untreated washed legs showed no changes in clinical grades, although conductance significantly decreased and the scaling indices increased in the last stage of the study. D-Squame analysis unequivocally revealed the beneficial effect of a moisturizer on soap-induced xerosis and the expected increase in scaliness without treatment.

  1. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury.

    Science.gov (United States)

    Davis, Angela R; Lotocki, George; Marcillo, Alex E; Dietrich, W Dalton; Keane, Robert W

    2007-05-01

    The Fas/CD95 receptor-ligand system plays an essential role in apoptosis that contributes to secondary damage after spinal cord injury (SCI), but the mechanism regulating the efficiency of FasL/Fas signaling in the central nervous system (CNS) is unknown. Here, FasL/Fas signaling complexes in membrane rafts were investigated in the spinal cord of adult female Fischer rats subjected to moderate cervical SCI and sham operation controls. In sham-operated animals, a portion of FasL, but not Fas was present in membrane rafts. SCI resulted in FasL and Fas translocation into membrane raft microdomains where Fas associates with the adaptor proteins Fas-associated death domain (FADD), caspase-8, cellular FLIP long form (cFLIPL ), and caspase-3, forming a death-inducing signaling complex (DISC). Moreover, SCI induced expression of Fas in clusters around the nucleus in both neurons and astrocytes. The formation of the DISC signaling platform leads to rapid activation of initiator caspase-8 and effector caspase-3, and the modification of signaling intermediates such as FADD and cFLIP(L) . Thus, FasL/Fas-mediated signaling after SCI is similar to Fas expressing Type I cell apoptosis.

  2. Lumbar disc cyst with contralateral radiculopathy

    Directory of Open Access Journals (Sweden)

    Kishore Tourani

    2012-08-01

    Full Text Available Disc cysts are uncommon intraspinal cystic lesions located in the ventrolateral epidural space. They communicate with the nucleus pulposus of the intervertebral disc and cause symptoms by radicular compression. We report a unique case of lumbar disc cyst that was associated with disc herniation and contralateral radiculopathy. A 22 year old male presented with one month history of back-ache radiating to the left leg. Magnetic Resonance Imaging (MRI showed L3-L4 disc herniation with annular tear and cystic lesion in the extradural space anterior to the thecal sac on right side, which increased in size over a period of 3 weeks. L3 laminectomy and bilateral discectomy and cyst excision was done with partial improvement of patients symptoms.

  3. Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration--an in vivo study on the New Zealand white rabbit.

    Science.gov (United States)

    Omlor, Georg W; Lorenz, Helga; Engelleiter, Karl; Richter, Wiltrud; Carstens, Claus; Kroeber, Markus W; Guehring, Thorsten

    2006-03-01

    The objective of the study was to improve the biological understanding of degenerative disc disease using a rabbit model in which different stages of disc degeneration are induced by variation of the duration of loading with an external compression-device applying 2.4 MPa. Gene expression and protein distribution were analyzed in controls and after 1, 28, and 56 days of hyperphysiologic loading. To evaluate extracellular matrix genes, quantitative real-time reverse-transcriptase polymerase chain reaction was applied for collagen I, collagen II, biglycan, decorin, fibromodulin, fibronectin, aggrecan, and osteonectin. As representatives of catabolic, anticatabolic, and anabolic factors, matrix metalloproteinase-13 (MMP-13), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and bone morphogenetic protein-2 (BMP-2) were chosen. To evaluate protein distribution, immunohistochemistry was performed for collagen I, collagen II, and BMP-2/4. Matrix gene expression was characterized by two major developments: collagen I and II, biglycan, and decorin showed early elevation followed by later downregulation to control levels, whereas fibromodulin, fibronectin, aggrecan, and osteonectin showed continuous upregulation or remained at similar levels. Induction of MMP-13 gene expression was found in degenerated discs. TIMP-1 and BMP-2 were elevated immediately after hyperphysiologic loading and presented highest levels in the 56-day group. Immunohistochemistry showed less collagen II and BMP-2/4 positive cells after compression. In conclusion, elevated matrix gene expression represents an early cellular response to hyperphysiologic loading. As degeneration progresses, some matrix genes increase upregulation, whereas others start downregulation. Continuous upregulation of catabolic, anticatabolic, and anabolic factors indicates their important role in the degeneration process. Copyright 2005 Orthopaedic Research Society.

  4. Quantum phase transition induced by real-space topology

    Science.gov (United States)

    Li, C.; Zhang, G.; Lin, S.; Song, Z.

    2016-12-01

    A quantum phase transition (QPT), including both topological and symmetry breaking types, is usually induced by the change of global parameters, such as external fields or global coupling constants. In this work, we demonstrate the existence of QPT induced by the real-space topology of the system. We investigate the groundstate properties of the tight-binding model on a honeycomb lattice with the torus geometry based on exact results. It is shown that the ground state experiences a second-order QPT, exhibiting the scaling behavior, when the torus switches to a tube, which reveals the connection between quantum phase and the real-space topology of the system.

  5. Quantum phase transition induced by real-space topology.

    Science.gov (United States)

    Li, C; Zhang, G; Lin, S; Song, Z

    2016-12-22

    A quantum phase transition (QPT), including both topological and symmetry breaking types, is usually induced by the change of global parameters, such as external fields or global coupling constants. In this work, we demonstrate the existence of QPT induced by the real-space topology of the system. We investigate the groundstate properties of the tight-binding model on a honeycomb lattice with the torus geometry based on exact results. It is shown that the ground state experiences a second-order QPT, exhibiting the scaling behavior, when the torus switches to a tube, which reveals the connection between quantum phase and the real-space topology of the system.

  6. Activation of the RAGE/STAT3 Pathway in the Dorsal Root Ganglion Contributes to the Persistent Pain Hypersensitivity Induced by Lumbar Disc Herniation.

    Science.gov (United States)

    Zhang, Xin-Sheng; Li, Xiao; Luo, Hai-Jie; Huang, Zhu-Xi; Liu, Cui-Cui; Wan, Qing; Xu, Shu-Wei; Wu, Shao-Ling; Ke, Song-Jian; Ma, Chao

    2017-07-01

    Clinically, chronic low back pain and sciatica associated with lumbar disc herniation (LDH) is a common musculoskeletal disorder. Due to the unawareness of detailed mechanisms, it is difficult to get an effective therapy. The aim of the present study was to identify the role of the RAGE/STAT3 pathway in the dorsal root ganglion (DRG) on the formation and development of persistent pain hypersensitivity induced by LDH. Controlled animal study. University laboratory. After LDH induced by implantation of autologous nucleus pulposus (NP, harvested from animal tail) on the left L5 nerve root was established, mechanical thresholds and electrophysiological tests were conducted at relevant time points during an observation period of 28 days. Protein levels and localization of RAGE and p-STAT3 were performed by using Western blotting and immunohistochemistry, respectively. LDH induced persistent pain hypersensitivity, increased excitability of DRG neurons, and upregulated the expression of RAGE and p-STAT3 in the DRG. Consecutive injection of both RAGE antagonist FPS-ZM1 (i.t.) and STAT3 activity inhibitor S3I-201 (i.t.) inhibited the enhanced excitability of DRG neurons and mechanical allodynia induced by NP implantation. Furthermore, local knockdown of STAT3 by intrathecal injection of AAV-Cre-GFP into STAT3flox/flox mice markedly alleviated NP implantation-induced mechanical allodynia in mice. Importantly, the expression of p-STAT3 was colocalized with that of RAGE in the DRG and inhibition of RAGE with FPS-ZM1 prevented NP implantation-induced STAT3 activation. More underlying mechanism(s) of the role of the RAGE/STAT3 pathway on the formation and development of persistent pain hypersensitivity induced by LDH will be needed to be explored in future research. These findings suggest activation of the RAGE/STAT3 pathway plays a critical role in persistent pain induced by LDH, and this pathway may represent novel therapeutic targets for the treatment of LDH-induced

  7. Light-induced disassembly of dusty bodies in inner protoplanetary discs: implications for the formation of planets

    CERN Document Server

    Wurm, Gerhard

    2007-01-01

    Laboratory experiments show that a solid-state greenhouse effect in combination with thermophoresis can efficiently erode a dust bed in a low-pressure gaseous environment. The surface of an illuminated, light absorbing dusty body is cooler than the dust below the surface (solidstate greenhouse effect). This temperature gradient leads to a directed momentum transfer between gas and dust particles and the dust particles are subject to a force towards the surface(thermophoresis). If the thermophoretic force is stronger than gravity and cohesion, dust particles are ejected. Applied to protoplanetary discs, dusty bodies smaller than several kilometres in size which are closer to a star than about 0.4 au are subject to a rapid and complete disassembly to submillimetre size dust aggregates by this process. While an inward-drifting dusty body is destroyed, the generated dust is not lost for the disc by sublimation or subsequent accretion on to the star but can be reprocessed by photophoresis or radiation pressure. Pl...

  8. Angular momentum transport in protostellar discs

    CERN Document Server

    Salmeron, Roberto Aureliano; Wardle, M; Salmeron, Raquel; Konigl, Arieh; Wardle, Mark

    2006-01-01

    Angular momentum transport in protostellar discs can take place either radially, through turbulence induced by the magnetorotational instability (MRI), or vertically, through the torque exerted by a large-scale magnetic field that threads the disc. Using semi-analytic and numerical results, we construct a model of steady-state discs that includes vertical transport by a centrifugally driven wind as well as MRI-induced turbulence. We present approximate criteria for the occurrence of either one of these mechanisms in an ambipolar diffusion-dominated disc. We derive ``strong field'' solutions in which the angular momentum transport is purely vertical and ``weak field'' solutions that are the stratified-disc analogues of the previously studied MRI channel modes; the latter are transformed into accretion solutions with predominantly radial angular-momentum transport when we implement a turbulent-stress prescription based on published results of numerical simulations. We also analyze ``intermediate field strength'...

  9. PDE4在DISC1突变诱发的精神分裂症中的作用%The role of PDE4 in DISC1 mutation-induced schizophrenia

    Institute of Scientific and Technical Information of China (English)

    张舒; 王允山

    2012-01-01

    精神分裂症断裂基因1 (disrupted in schizophrenia 1,DISC1)是多种精神疾病中的一个关键的遗传学危险因素.DISC1能够与磷酸二酯酶4 (phosphodiesterase 4,PDE4)相互作用形成复合物,这可能是一些精神疾病的关键分子机制.PDE4能够水解cAMP,DISC1可通过调节PDE4的活性进而发挥调节cAMP在细胞内的信号转导功能.已有研究证实,在一些精神疾病患者中,DISC1和PDE4基因表达均发生了变化.DISC1突变导致其表达产物与PDE4的相互作用减弱,结果之一是降低脑PDE4的活性.DISC1与PDE4之间的相互作用的改变可能是精神分裂症及抑郁症等疾病症状产生的基础.%Disrupted in schizophrenia 1 (DISC1) is an important genetic risk factor for many mental diseases. DISC1 interacts directly with phosphodiesterase 4 (PDE4), and DISC1-PDE4 complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illnesses. PDE4 hydrolyses cAMP, and DISCI may regulate cAMP signalling through modulating PDE4 activity. There is evidence that the expression of both genes (DISCI and PDE4) is altered in some psychiatric patients. The mutation in DISCI reduces the interaction between DISCI and PDE4, and results in reduction of the activity of brain PDE4. Altered DISC1-PDE4 interaction may underlie the symptoms of schizophrenia and depression.

  10. The quiescent phase of galactic disc growth

    Science.gov (United States)

    Aumer, Michael; Binney, James; Schönrich, Ralph

    2016-07-01

    We perform a series of controlled N-body simulations of growing disc galaxies within non-growing, live dark matter haloes of varying mass and concentration. Our initial conditions include either a low-mass disc or a compact bulge. New stellar particles are continuously added on near-circular orbits to the existing disc, so spiral structure is continuously excited. To study the effect of combined spiral and giant molecular cloud (GMC) heating on the discs, we introduce massive, short-lived particles that sample a GMC mass function. An isothermal gas component is introduced for a subset of the models. We perform a resolution study and vary parameters governing the GMC population, the histories of star formation and radial scale growth. Models with GMCs and standard values for the disc mass and halo density provide the right level of self-gravity to explain the age-velocity dispersion relation of the solar neighbourhood (Snhd). GMC heating generates remarkably exponential vertical profiles with scaleheights that are radially constant and agree with observations of galactic thin discs. GMCs are also capable of significantly delaying bar formation. The amount of spiral-induced radial migration agrees with what is required for the metallicity distribution of the Snhd. However, in our standard models, the outward-migrating populations are not hot enough vertically to create thick discs. Thick discs can form in models with high baryon fractions, but the corresponding bars are too long, the young stellar populations too hot and the discs flare considerably.

  11. DSC Study of Collagen in Disc Disease

    Directory of Open Access Journals (Sweden)

    S. Skrzyński

    2009-01-01

    Full Text Available Differential scanning calorimetry (DSC has been used to estimate the effect of disc disease on the collagen helix-coil transition and morphology for tissue extracted from patients during surgical operation. Forty discs were obtained from patients with degenerative disc disease undergoing surgery for low back pain. The patients were in the age between 20 and 70 years old. The specimens were kept wet during DSC experiment. The data allow the comparison between thermal stability of collagen tissue from healthy patients and from patients suffering from disc disease. In the paper the comparison between thermal helix-coil transition for collagen fibers from patients suffering from disc disease and collagen fibers from healthy organisms has been discussed. The heating rate has an influence on the position on denaturation temperatures of collagen in disc tissues. Higher helix-coil transition temperature of collagen in degenerated disc suggests that additional intermolecular cross linking of collagen fibers occurs. Denaturation temperatures of collagen in degenerated male disc possess smaller values than in female ones. Disc disease induces changes in collagen structure and leads to formation of additional crosslinks between collagen fibers.

  12. About detection of precessing circumpulsar discs

    Science.gov (United States)

    Grimani, Catia

    2016-08-01

    Detections of circumpulsar discs and planetary systems through electromagnetic observations appear quite rare. In the case of PSR 1931+24 and B0656+14, the hypothesis of a precessing disc penetrating the pulsar light cylinder is found consistent with radio and gamma observations from these stars. Disc self-occultation and precession may affect electromagnetic measurements. We investigate here under which conditions gravitational waves generated by circumpulsar disc precession may be detected by the proposed second-generation space interferometers DECI-hertz Interferometer Gravitational Wave Observatory and Big Bang Observer. The characteristics of circumpulsar detectable precessing discs are estimated as a function of distance from the Solar system. Speculations on detection rates are presented.

  13. Combined raman/laser-induced breakdown spectrometer: space and non-space applications

    NARCIS (Netherlands)

    Sandtke, M.; Laan, E.C.; Ahlers, B.

    2010-01-01

    TNO has developed the combination of two spectroscopic analysis methods in one instrument. Raman spectroscopy and Laser-induced Breakdown Spectroscopy (LIBS) were brought together for an instrument to be flown on the ExoMars mission from the European Space Agency (ESA) to investigate the Martian (su

  14. Combined raman/laser-induced breakdown spectrometer: space and non-space applications

    NARCIS (Netherlands)

    Sandtke, M.; Laan, E.C.; Ahlers, B.

    2010-01-01

    TNO has developed the combination of two spectroscopic analysis methods in one instrument. Raman spectroscopy and Laser-induced Breakdown Spectroscopy (LIBS) were brought together for an instrument to be flown on the ExoMars mission from the European Space Agency (ESA) to investigate the Martian

  15. "Tilt" in color space: Hue changes induced by chromatic surrounds.

    Science.gov (United States)

    Klauke, Susanne; Wachtler, Thomas

    2015-01-01

    The perceived color of a chromatic stimulus is influenced by the chromaticity of its surround. To investigate these influences along the dimension of hue, we measured hue changes induced in stimuli of different hues by isoluminant chromatic surrounds. Generally, induced hue changes were directed in color space away from the hue of the inducing surround and depended on the magnitude on the hue difference between stimulus and surround. With increasing difference in hue between stimulus and surround, induced hue changes increased up to a maximum and then decreased for larger differences. This qualitative pattern was similar for different inducers, but quantitatively, induction was weaker along some directions in cone-opponent color space than along other directions. The strongest induction effects were found along an oblique, blue-yellow axis that corresponds to the daylight axis. The overall pattern of the induction effect shows similarities to the well-known tilt effect, where shifts in perceived angle of oriented stimuli are induced by oriented surrounds. This suggests analogous neural representations and similar mechanisms of contextual processing for different visual features such as orientation and color.

  16. [Controlled distraction as a therapeutic option in moderate degeneration of the intervertebral disc -- an in vivo study in the rabbit-spine model].

    Science.gov (United States)

    Unglaub, F; Guehring, T; Omlor, G; Lorenz, H; Carstens, C; Kroeber, M W

    2006-01-01

    The aim of this study was to investigate the effects of temporary distraction on a degenerated intervertebral disc to characterize regenerative changes associated with disc distraction. New Zealand white rabbits (n = 32) were used for this experimental animal study. The rabbits were randomly assigned to one of five groups. 6 animals were loaded for 28 days using a custom-made external loading device to stimulate disc degeneration (G2). In 6 animals the discs were first loaded for 28 days and after 28 days loading time the discs in six animals were treated as dynamic distraction with an external distraction device (G1). In six animals the discs were distracted for 28 days without previous loading (G5) and in six animals the discs were loaded for 28 days and afterwards the loading device was removed for 28 days for recovery without distraction (G3). Six animals were sham operated (G4) without application of axial load. After 28 to 56 days loading and distraction time, the animals were sacrificed and the lumbar spine was harvested for histological and radiographic analysis. Histology was performed according to a degeneration score and disc height was calculated radiographically. For the cell viability examination, the number of apoptotic cells was determined. After 28 days of loading (G2), the discs showed a significant decrease in disc space of the treated segment. Histologically, a disorganization of the architecture of the annulus occurred. The number of dead cells increased significantly in the annulus and cartilage endplate. These changes were reversible after 28 days of distraction (G1). The disc thickness increased significantly to physiological levels as compared to the specimens from the 28 days loading group without distraction. Histologically, the discs showed signs of tissue regeneration after 28 days of distraction (G1). The number of apoptotic cells decreased significantly in comparison to the loaded discs without distraction (G2). The results of this

  17. Dynamos in accretion discs

    OpenAIRE

    Brandenburg, A.; von Rekowski, B.

    2007-01-01

    It is argued that accretion discs in young stellar objects may have hot coronae that are heated by magnetic reconnection. This is a consequence of the magneto-rotational instability driving turbulence in the disc. Magnetic reconnection away from the midplane leads to heating of the corona which, in turn, contributes to driving disc winds.

  18. The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.

    Science.gov (United States)

    Feng, Chencheng; Zhang, Yang; Yang, Minghui; Lan, Minghong; Liu, Huan; Wang, Jian; Zhou, Yue; Huang, Bo

    2017-01-01

    Intervertebral disc (IVD) cell senescence is a recognized mechanism of intervertebral disc degeneration (IDD). Elucidating the molecular mechanisms underlying disc cell senescence will contribute to understanding the pathogenesis of IDD. We previously reported that N-acetylated proline-glycine-proline (N-Ac-PGP), a matrikine, is involved in the process of IDD. However, its roles in IDD are not well understood. Here, using rat nucleus pulposus (NP) cells, we found that N-Ac-PGP induced premature senescence of NP cells by binding to CXCR1. N-Ac-PGP induced DNA damage and reactive oxygen species accumulation in NP cells, which resulted in activation of the p53-p21-Rb and p16-Rb pathways. Moreover, the RT(2) profiler PCR array showed that N-Ac-PGP down-regulates the expression of antioxidant genes in NP cells, suggesting a decline in the antioxidants of NP cells. On the other hand, N-Ac-PGP up-regulated the expression of matrix catabolic genes and inflammatory genes in NP cells. Concomitantly, N-Ac-PGP reinforced the destructive effects of senescent NP cells on the homeostasis of the IVDs in vivo. Our study suggests that N-Ac-PGP plays critical roles in the pathogenesis of IDD through the induction of premature senescence of disc cells and via the activation of catabolic and inflammatory cascades in disc cells. N-Ac-PGP also deteriorates the redox environment of disc cells. Hence, N-Ac-PGP is a new potential therapeutic target for IDD.

  19. Compensating tune spread induced by space charge in bunched beams

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.; Wang, G.

    2015-05-03

    The effects of space charge play a significant role in modern-day accelerators, frequently constraining the beam parameters attainable in an accelerator or in an accelerator chain. They also can limit the luminosity of hadron colliders operating either at low energies or with sub-TeV high-brightness hadron beams. The latter is applied for strongly cooled proton and ion beams in eRHIC – the proposed future electron-ion collider at Brookhaven National Laboratory. Using an appropriate electron beam would compensate both the tune shift and the tune spread in the hadron beam in a coasting beam. But these methods cannot compensate space charge tune spread in a bunched hadron beam. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with mismatched longitudinal velocity to compensate the space charge induced tune-shift and tune spread.

  20. Compensating tune spread induced by space charge in bunched beams

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.; Wang, G.

    2015-05-03

    The effects of space charge play a significant role in modern-day accelerators, frequently constraining the beam parameters attainable in an accelerator or in an accelerator chain. They also can limit the luminosity of hadron colliders operating either at low energies or with sub-TeV high-brightness hadron beams. The latter is applied for strongly cooled proton and ion beams in eRHIC – the proposed future electron-ion collider at Brookhaven National Laboratory. Using an appropriate electron beam would compensate both the tune shift and the tune spread in the hadron beam in a coasting beam. But these methods cannot compensate space charge tune spread in a bunched hadron beam. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with mismatched longitudinal velocity to compensate the space charge induced tune-shift and tune spread.

  1. Groups, cacti and framed little discs

    CERN Document Server

    Hepworth, Richard

    2010-01-01

    Let G be a topological group. Then the based loopspace of G is an algebra over the cacti operad, while the double loopspace of the classifying space of G is an algebra over the framed little discs operad. This paper shows that these two algebras are equivalent, in the sense that they are weakly equivalent E-algebras, where E is an operad weakly equivalent to both framed little discs and cacti. We recover the equivalence between cacti and framed little discs, and Menichi's isomorphism between the BV-algebras obtained by taking the homology of the loopspace of G and of the double loopspace of BG.

  2. Tearing up a misaligned accretion disc with a binary companion

    CERN Document Server

    Doğan, Suzan; King, Andrew; Price, Daniel J

    2015-01-01

    Accretion discs are common in binary systems, and they are often found to be misaligned with respect to the binary orbit. The gravitational torque from a companion induces nodal precession in misaligned disc orbits. We calculate whether this precession is strong enough to overcome the internal disc torques communicating angular momentum. For typical parameters precession wins: the disc breaks into distinct planes that precess effectively independently. We run hydrodynamical simulations to check these results, and confirm that disc breaking is widespread and generally enhances accretion on to the central object. This applies in many cases of astrophysical accretion, e.g. supermassive black hole binaries and X--ray binaries.

  3. Unsuccessful vitrectomy without gas tamponade for macular retinal detachment and retinoschisis without optic disc pit.

    Science.gov (United States)

    Hotta, Kazuki

    2004-01-01

    The mechanism of subretinal fluid accumulation in optic disc pit maculopathy is unknown. A 67-year-old Japanese woman complaining of blurred vision in her right eye presented with a best-corrected visual acuity of 20/200. Slit-lamp biomicroscopy and optical coherence tomography examination showed maculopathy typically associated with optic disc pits, except that the patient had no optic disc pit. Long-acting gas tamponade was required to achieve reattachment of the retina and retinoschisis after initial failure of surgery using surgically induced vitreous detachment without either fluid-air exchange or gas injection. Vitreous traction may not have played a major role in introducing fluid into the submacular space in this case. Gas tamponade may be indispensable to achieve surgical success. This may also pertain to some cases of optic nerve pits.

  4. Connection of Screw Instability with Electric Current in an Accretion Disc around a Black Hole

    Institute of Scientific and Technical Information of China (English)

    LAN Xiao-Xia; WANG Ding-Xiong; GAN Zhao-Ming

    2005-01-01

    @@ The screw instability of the magnetic field is discussed based on its poloidal configuration generated by a single toroidal electric current flowing in the equatorial plane of a Kerr Mack hole (BH). The rotation of the BH relative to the disc induces an electromotive force, which in turn results in a poloidal electric current. By using Ampere's law, we calculate the toroidal component of the magnetic field and derive a criterion for the screw instability of the magnetic field connecting the rotating BH with its surrounding disc. It is determined that the screw instability is related to two parameters: the radius of the disc and the BH spin. The occurrence of screw instability is depicted in a parameter space. In addition, we discuss the effect of the screw instability on magnetic extraction of energy from the rotating BH.

  5. [Research advances in animal models of intervertebral disc degeneration].

    Science.gov (United States)

    Zhang, Wenli; Liu, Hao; Li, Tanzhu

    2007-11-01

    To review the research advances in animal models of human disc degeneration. The relative articles in recent years were extensively reviewed. Studies both at home and abroad were analyzed and classified. The advantages and disadvantages of each method were compared. Studies were classified as either experimentally induced models or spontaneous models. The induced models were subdivided as mechanical (alteration of forces on the normal disc), structural (injury or chemical alteration) and genetically induced models. Spontaneous models included those animals that naturally developed degenerative disc disease. Animal model of intervertebral disc degeneration is an important path for revealing the pathogenesis of human disc degeneration, and play an important role in testing novel interventions. With recent advances in the relevance of animal models and humans, it has a great prospect in study of human disc degeneration.

  6. MHD disc winds

    CERN Document Server

    Ferreira, J

    2006-01-01

    This is a doctorate level lecture on the physics of accretion discs driving magnetically self-confined jets, usually referred to in the literature as disc winds. I will first review the governing magnetohydrodynamic equations and then discuss their physical content. At that level, necessary conditions to drive jets from keplerian accretion discs can already be derived. These conditions are validated with self-similar calculations of accretion-ejection structures. In a second part, I will critically discuss the biases introduced when using self-similarity as well as some other questions such as: Are these systems really unstable? Can a standard accretion disc provide the conditions to launch jets in its innermost parts? What is the difference between X-winds and disc-winds? Finally, the magnetic interaction between a protostar and its circumstellar disc will be discussed with a focus on stellar spin down.

  7. Black hole accretion discs

    OpenAIRE

    Lasota, Jean-Pierre

    2015-01-01

    This is an introduction to models of accretion discs around black holes. After a presentation of the non-relativistic equations describing the structure and evolution of geometrically thin accretion discs we discuss their steady-state solutions and compare them to observation. Next we describe in detail the thermal-viscous disc instability model and its application to dwarf novae for which it was designed and its X-ray irradiated-disc version which explains the soft X--ray transients, i.e. ou...

  8. Stem cells sources for intervertebral disc regeneration

    Institute of Scientific and Technical Information of China (English)

    Gianluca; Vadalà; Fabrizio; Russo; Luca; Ambrosio; Mattia; Loppini; Vincenzo; Denaro

    2016-01-01

    Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible treatments.Indeed, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers(e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

  9. Space-radiation-induced Photon Luminescence of the Moon

    Science.gov (United States)

    Wilson, Thomas; Lee, Kerry

    2008-01-01

    We report on the results of a study of the photon luminescence of the Moon induced by Galactic Cosmic Rays (GCRs) and space radiation from the Sun, using the Monte Carlo program FLUKA. The model of the lunar surface is taken to be the chemical composition of soils found at various landing sites during the Apollo and Luna programs, averaged over all such sites to define a generic regolith for the present analysis. This then becomes the target that is bombarded by Galactic Cosmic Rays (GCRs) and Solar Energetic Particles (SEPs) above 1 keV in FLUKA to determine the photon fluence albedo produced by the Moon's surface when there is no sunlight and Earthshine. This is to be distinguished from the gamma-ray spectrum produced by the radioactive decay of radiogenic constituents lying in the surface and interior of the Moon. From the photon fluence we derive the spectrum which can be utilized to examine existing lunar spectral data and to design orbiting instrumentation for measuring various components of the space-radiation-induced photon luminescence present on the Moon.

  10. Flow induced vibrations in arrays of irregularly spaced cylinders

    Science.gov (United States)

    Taub, Gordon; Michelin, Sébastien

    2014-11-01

    Historically the main industrial applications of cylinder arrays in cross flows favored regular arrangements of cylinders. For this reason, most past studies of Flow Induced Vibrations (FIV) in large cylinder arrays have focused on such arrangements. Recently there has been some interest in generating renewable energy using FIV of bluff bodies. In such applications it will likely be beneficial to enhance, rather than suppress FIV. It is not known a priori if regular or irregularly spaced arrays are most adequate for this type of application. In this study, wind tunnel experiments were conducted on one regularly spaced array and four different irregularly spaced arrays of cylinders in a cross flow. Each arrangement of cylinders was examined under eight different orientations to a cross flow ranging between 10 m/s and 17 m/s. The average amplitude of vibration of the cylinders was found to highly depend on arrangement and orientation. The typical amplitude of vibration of the rods in the irregular arrangements were found to be an order of magnitude larger than that of the regular array. A simple model was proposed in order to predict if a given arrangement was likely to produce large oscillations, and the validity of the model was examined. This research was supported by a Marie Curie International Reintegration Grant within the 7th European Community Framework Program (Grant PIRG08-GA-2010-276762).

  11. Eclipse Mapping: Astrotomography of Accretion Discs

    CERN Document Server

    Baptista, Raymundo

    2015-01-01

    The Eclipse Mapping Method is an indirect imaging technique that transforms the shape of the eclipse light curve into a map of the surface brightness distribution of the occulted regions. Three decades of application of this technique to the investigation of the structure, the spectrum and the time evolution of accretion discs around white dwarfs in cataclysmic variables have enriched our understanding of these accretion devices with a wealth of details such as (but not limited to) moving heating/cooling waves during outbursts in dwarf novae, tidally-induced spiral shocks of emitting gas with sub-Keplerian velocities, elliptical precessing discs associated to superhumps, and measurements of the radial run of the disc viscosity through the mapping of the disc flickering sources. This chapter reviews the principles of the method, discusses its performance, limitations, useful error propagation procedures, as well as highlights a selection of applications aimed at showing the possible scientific problems that ha...

  12. Effects of unisegmental disc compression on adjacent segments: an in vivo animal model.

    Science.gov (United States)

    Unglaub, Frank; Guehring, Thorsten; Lorenz, Helga; Carstens, Claus; Kroeber, Markus W

    2005-12-01

    It is controversial whether fusion of discs in the spine leads to increased degeneration on the remaining discs or whether the degenerative changes are merely a part of the inevitable natural history process. To determine the effects of unisegmental compression and subsequent recovery on adjacent segments, we studied histology, radiology and intradiscal pressure using an in vivo rabbit model. Fifteen New Zealand rabbits were divided in to three groups of five. In the first group, the intervertebral disc L4-L5 of the lumbar spine was axially loaded for 28 days with an external loading device. In the second group, the intervertebral disc was compressed for 28 days and allowed to recover for an equal amount of time, with the loading device removed. Five animals underwent a sham operation, in which the external loading device was situated, but their discs remained unloaded for 28 days. The intradiscal pressure was determined in the loaded discs as well as in the cranial and caudal adjacent discs. Lateral radiographs were taken from each subjected intervertebral disc with adjacent vertebral bodies and the cranial and caudal adjacent segments. The compressed discs showed lower intradiscal pressure in comparison with the control group, which remained unloaded. In the cranial and caudal discs adjacent to the loaded discs the average intradiscal pressure was similar to the unloaded controls. The loaded discs demonstrated a significant decrease in disc space. No discs adjacent to the loaded discs changed in height. The lamellar architecture of the inner, middle, and outer annulus became more disorganized in the loaded discs. The nucleus pulposus showed increase of mucoid degeneration and increased cell death. Intervertebral discs from the control group and the adjacent discs to the compressed discs maintained their normal morphology. This study shows that mechanical loading of discs in the spine can cause rapid degeneration. Adjacent discs, however, did not change in terms

  13. Time-dependence of non-planar accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Papaloizou, J.C.B. (Queen Mary Coll., London (UK). Dept. of Applied Mathematics); Pringle, J.E. (Amsterdam Univ. (Netherlands). Astronomical Inst.)

    1983-03-01

    Equations are derived which describe the time-dependence of a viscous, tilted accretion disc subject to external torques. A full hydrodynamical treatment is used and the equations linearized in terms of a small tilt. It is shown that previous attempts at deriving these equations are inadequate due to the inconsistency of some of the assumptions made. The behaviour of a tilted viscous disc is not simple to describe. Viscous forces tend to flatten the disc, but they also produce torques within the disc which induce local precession of disc elements. The main complication is that the horizontal motions induced in the disc by the tilt are resonantly driven so that their magnitude and phase are governed by the viscosity. This leads to the disc being smoothed on a time-scale faster than the usual viscous one. In order to obtain a simple diffusion equation governing the tilt angle ..beta.., it is necessary in a Keplerian disc that the viscosity parameter ..cap alpha.. be greater than the opening angle of the disc (H/R). If this condition is not satisfied consideration must be given to the proper dynamical modes of the disc, and the simple approach to the problem adopted here is inadequate.

  14. Countermeasures for Space Radiation Induced Malignancies and Acute Biological Effects

    Science.gov (United States)

    Kennedy, Ann

    The hypothesis being evaluated in this research program is that control of radiation induced oxidative stress will reduce the risk of radiation induced adverse biological effects occurring as a result of exposure to the types of radiation encountered during space travel. As part of this grant work, we have evaluated the protective effects of several antioxidants and dietary supplements and observed that a mixture of antioxidants (AOX), containing L-selenomethionine, N-acetyl cysteine (NAC), ascorbic acid, vitamin E succinate, and alpha-lipoic acid, is highly effective at reducing space radiation induced oxidative stress in both in vivo and in vitro systems, space radiation induced cytotoxicity and malignant transformation in vitro [1-7]. In studies designed to determine whether the AOX formulation could affect radiation induced mortality [8], it was observed that the AOX dietary supplement increased the 30-day survival of ICR male mice following exposure to a potentially lethal dose (8 Gy) of X-rays when given prior to or after animal irradiation. Pretreatment of animals with antioxidants resulted in significantly higher total white blood cell and neutrophil counts in peripheral blood at 4 and 24 hours following exposure to doses of 1 Gy and 8 Gy. Antioxidant treatment also resulted in increased bone marrow cell counts following irradiation, and prevented peripheral lymphopenia following 1 Gy irradiation. Supplementation with antioxidants in irradiated animals resulted in several gene expression changes: the antioxidant treatment was associated with increased Bcl-2, and decreased Bax, caspase-9 and TGF-β1 mRNA expression in the bone marrow following irradiation. These results suggest that modulation of apoptosis may be mechanistically involved in hematopoietic system radioprotection by antioxidants. Maintenance of the antioxidant diet was associated with improved recovery of the bone marrow following sub-lethal or potentially lethal irradiation. Taken together

  15. Optic disc oedema

    DEFF Research Database (Denmark)

    Nielsen, Marianne Kromann; Hamann, Steffen

    2014-01-01

    Optic disc oedema describes the nonspecific, localized swelling of the optic nerve head regardless of aetiology. Therefore, differentiating among the various aetiologies depends on a thorough history and knowledge of the clinical characteristics of the underlying conditions. Papilloedema strictly...... refers to optic disc oedema as a consequence of elevated intracranial pressure. It is usually a bilateral condition and visual function is preserved until late. Optic disc oedema caused by an anterior optic neuropathy is usually unilateral and accompanied by the loss of visual function....

  16. Accretion disc viscosity: a limit on the anisotropy

    CERN Document Server

    Nixon, Chris

    2015-01-01

    Observations of warped discs can give insight into the nature of angular momentum transport in accretion discs. Only a few objects are known to show strong periodicity on long timescales, but when such periodicity is present it is often attributed to precession of the accretion disc. The X-ray binary Hercules X-1/HZ Herculis (Her X-1) is one of the best examples of such periodicity and has been linked to disc precession since it was first observed. By using the current best-fitting models to Her X-1, which invoke precession driven by radiation warping, I place a constraint on the effective viscosities that act in a warped disc. These effective viscosities almost certainly arise due to turbulence induced by the magneto-rotational instability. The constraints derived here are in agreement with analytical and numerical investigations into the nature of magneto-hydrodynamic disc turbulence, but at odds with some recent global simulations.

  17. Artificial Disc Replacement

    Science.gov (United States)

    ... Strengthening Strengthen Your Core! Stretching/Flexibility Aerobic Exercise Cervical ... disc is the soft cushioning structure located between the individual bones of the spine, called “vertebra.” It is made of cartilage-like tissue and ...

  18. Goddard Earth Sciences Data and Information Services Center (GES DISC)

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC) is the home (archive) of Precipitation, Atmospheric Chemistry and Dynamics, and...

  19. Dynamical instabilities in disc-planet interactions

    CERN Document Server

    Lin, Min-Kai

    2012-01-01

    Protoplanetary discs may become dynamically unstable due to structure induced by an embedded giant planet. In this thesis, I discuss the stability of such systems and explore the consequence of instability on planetary migration. I begin with non-self-gravitating, low viscosity discs and show that giant planets induce shocks inside its co-orbital region, leading to a profile unstable to vortex formation around a potential vorticity minimum. This instability is commonly known as the vortex or Rossby wave instability. Vortex-planet interaction lead to episodic phases of migration, which can be understood in the framework of type III migration. I then examine the effect of disc self-gravity on gap stability. The linear theory of the Rossby wave instability is extended to include disc gravity, which shows that self-gravity is effective at stabilising the vortex instability at small azimuthal wavenumber. This is consistent with the observation that more vortices develop with increasing disc mass in hydrodynamic si...

  20. Lipopolysaccharide induced inflammation in the perivascular space in lungs

    Directory of Open Access Journals (Sweden)

    Pabst Reinhard

    2008-07-01

    Full Text Available Abstract Background Lipopolysaccharide (LPS contained in tobacco smoke and a variety of environmental and occupational dusts is a toxic agent causing lung inflammation characterized by migration of neutrophils and monocytes into alveoli. Although migration of inflammatory cells into alveoli of LPS-treated rats is well characterized, the dynamics of their accumulation in the perivascular space (PVS leading to a perivascular inflammation (PVI of pulmonary arteries is not well described. Methods Therefore, we investigated migration of neutrophils and monocytes into PVS in lungs of male Sprague-Dawley rats treated intratracheally with E. coli LPS and euthanized after 1, 6, 12, 24 and 36 hours. Control rats were treated with endotoxin-free saline. H&E stained slides were made and immunohistochemistry was performed using a monocyte marker and the chemokine Monocyte-Chemoattractant-Protein-1 (MCP-1. Computer-assisted microscopy was performed to count infiltrating cells. Results Surprisingly, the periarterial infiltration was not a constant finding in each animal although LPS-induced alveolitis was present. A clear tendency was observed that neutrophils were appearing in the PVS first within 6 hours after LPS application and were decreasing at later time points. In contrast, mononuclear cell infiltration was observed after 24 hours. In addition, MCP-1 expression was present in perivascular capillaries, arteries and the epithelium. Conclusion PVI might be a certain lung reaction pattern in the defense to infectious attacks.

  1. Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats.

    Science.gov (United States)

    Krupkova, O; Sekiguchi, M; Klasen, J; Hausmann, O; Konno, S; Ferguson, S J; Wuertz-Kozak, K

    2014-11-25

    Intervertebral disc (IVD) disease, which is characterised by age-related changes in the adult disc, is the most common cause of disc failure and low back pain. The purpose of this study was to analyse the potential of the biologically active polyphenol epigallocatechin 3-gallate (EGCG) for the treatment of painful IVD disease by identifying and explaining its anti-inflammatory and anti-catabolic activity. Human IVD cells were isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D. An inflammatory response was activated by IL-1β, EGCG was added, and the expression/activity of inflammatory mediators and pathways was measured by qRT-PCR, western blotting, ELISA, immunofluorescence and transcription factor assay. The small molecule inhibitor SB203580 was used to investigate the involvement of the p38 pathway in the observed effects. The analgesic properties of EGCG were analysed by the von Frey filament test in Sprague-Dawley rats (n = 60). EGCG significantly inhibited the expression of pro-inflammatory mediators and matrix metalloproteinases in vitro, as well as radiculopathic pain in vivo, most probably by modulation of the activity of IRAK-1 and its downstream effectors p38, JNK and NF-κB.

  2. Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats

    Directory of Open Access Journals (Sweden)

    O Krupkova

    2014-11-01

    Full Text Available Intervertebral disc (IVD disease, which is characterised by age-related changes in the adult disc, is the most common cause of disc failure and low back pain. The purpose of this study was to analyse the potential of the biologically active polyphenol epigallocatechin 3-gallate (EGCG for the treatment of painful IVD disease by identifying and explaining its anti-inflammatory and anti-catabolic activity. Human IVD cells were isolated from patients undergoing surgery due to degenerative disc disease (n = 34 and cultured in 2D or 3D. An inflammatory response was activated by IL-1β, EGCG was added, and the expression/activity of inflammatory mediators and pathways was measured by qRT-PCR, western blotting, ELISA, immunofluorescence and transcription factor assay. The small molecule inhibitor SB203580 was used to investigate the involvement of the p38 pathway in the observed effects. The analgesic properties of EGCG were analysed by the von Frey filament test in Sprague-Dawley rats (n = 60. EGCG significantly inhibited the expression of pro-inflammatory mediators and matrix metalloproteinases in vitro, as well as radiculopathic pain in vivo, most probably by modulation of the activity of IRAK-1 and its downstream effectors p38, JNK and NF-κB.

  3. The treatment of disc herniation-induced sciatica with infliximab - One-year follow-up results of FIRST II, a randomized controlled trial

    NARCIS (Netherlands)

    Korhonen, Timo; Karppinen, Jaro; Paimela, Leena; Malmivaara, Antti; Lindgren, Karl-August; Bowman, Chris; Hammond, Anthony; Kirkham, Bruce; Jarvinen, Simo; Niinimaki, Jaakko; Veeger, Nic; Haapea, Marianne; Torkki, Markus; Tervonen, Osmo; Seitsalo, Seppo; Hurri, Heikki

    2006-01-01

    Study Design. A randomized controlled trial. Objectives. To evaluate the long-term efficacy of infliximab, a monoclonal antibody against tumor necrosis factor alpha (TNF-alpha), in patients with acute/subacute sciatica secondary to herniated disc. Summary of Background Data. The results of experimen

  4. Biomechanical and biochemical outcomes of porcine temporomandibular joint disc deformation.

    Science.gov (United States)

    Matuska, Andrea M; Muller, Stephen; Dolwick, M Franklin; McFetridge, Peter S

    2016-04-01

    The structure-function relationship in the healthy temporomandibular joint (TMJ) disc has been well established, however the changes in dysfunctional joints has yet to be systematically evaluated. Due to the poor understanding of the etiology of temporomandibular disorders (TMDs) this study evaluated naturally occurring degenerative remodeling in aged female porcine temporomandibular joint (TMJ) discs in order to gain insight into the progression and effects on possible treatment strategies of TMDs. Surface and regional biomechanical and biochemical properties of discal tissues were determined in grossly deformed (≥Wilkes Stage 3) and morphologically normal (≤Wilkes Stage 2) TMJ discs. Compared to normal disc structure the deformed discs lacked a smooth biconcave shape and characteristic ECM organization. Reduction in tensile biomechanical integrity and increased compressive stiffness and cellularity was found in deformed discs. Regionally, the posterior and intermediate zones of the disc were most frequently affected along with the inferior surface. The frequency of degeneration observed on the inferior surface of the disc (predominantly posterior), suggests that a disruption in the disc-condyle relationship likely contributes to the progression of joint dysfunction more than the temporodiscal relationship. As such, the inferior joint space may be an important consideration in early clinical diagnosis and treatment of TMDs, as it is overlooked in techniques performed in the upper joint space, including arthroscopy and arthrocentesis. Furthermore, permanent damage to the disc mechanical properties would limit the ability to successfully reposition deformed discs, highlighting the importance of emerging therapies such as tissue engineering. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Discs of Satellites: the new dwarf spheroidals

    CERN Document Server

    Metz, Manuel; Jerjen, Helmut

    2009-01-01

    The spatial distributions of the most recently discovered ultra faint dwarf satellites around the Milky Way and the Andromeda galaxy are compared to the previously reported discs-of-satellites (DoS) of their host galaxies. In our investigation we pay special attention to the selection bias introduced due to the limited sky coverage of SDSS. We find that the new Milky Way satellite galaxies follow closely the DoS defined by the more luminous dwarfs, thereby further emphasizing the statistical significance of this feature in the Galactic halo. We also notice a deficit of satellite galaxies with Galactocentric distances larger than 100 kpc that are away from the disc-of-satellites of the Milky Way. In the case of Andromeda, we obtain similar results, naturally complementing our previous finding and strengthening the notion that the discs-of-satellites are optical manifestations of a phase-space correlation of satellite galaxies.

  6. Wind interactions above accretion discs: a model for broad-line regions and collimated outflow

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.D.; Raine, D.J. (Leicester Univ. (UK). Dept. of Astronomy)

    1985-01-15

    The interaction of a wind from an active galactic nucleus with a Compton-heating-induced wind from an accretion disc is studied. The nuclear wind is taken as initially supersonic and spherically symmetric. The disc wind arises when the disc surface is exposed to a hard and powerful X-ray source. Three classes of interaction are identified in terms of the relation between the pressure on the disc surface and the corresponding thermal and ram pressures in the nuclear wind.

  7. Breaking the disc-halo degeneracy in NGC 1291 using hydrodynamic simulations

    CERN Document Server

    Fragkoudi, F; Bosma, A

    2016-01-01

    We present a pilot study on the nearby massive galaxy NGC 1291, in which we aim to constrain the dark matter in the inner regions, by obtaining a dynamical determination of the disc mass-to-light ratio (M/L). To this aim, we model the bar-induced dust lanes in the galaxy, using hydrodynamic gas response simulations. The models have three free parameters, the M/L of the disc, the bar pattern speed and the disc height function. We explore the parameter space to find the best fit models, i.e. those in which the morphology of the shocks in the gas simulations matches the observed dust lanes. The best-fit models suggest that the M/L of NGC 1291 agrees with that predicted by stellar population synthesis models in the near-infrared ($\\approx$0.6\\,$M_{\\odot}/L_{\\odot}$), which leads to a borderline maximum disc for this galaxy. The bar rotates fast, with corotation radius $\\leq$ 1.4 times the bar length. Additionally, we find that the height function has a significant effect on the results, and can bias them towards ...

  8. Innervation of ''painful'' lumbar discs

    NARCIS (Netherlands)

    Coppes, MH; Marani, E; Thomeer, RTWM; Groen, GJ

    1997-01-01

    Study Design. The authors investigated the innervation of discographically confirmed degenerated and ''painful'' human intervertebral discs. Objective. To determine the type and distribution patterns of nerve fibers present in degenerated human intervertebral discs. Summary of Background Data. The i

  9. Investigation of Product Performance of Al-Metal Matrix Composites Brake Disc using Finite Element Analysis

    Science.gov (United States)

    Fatchurrohman, N.; Marini, C. D.; Suraya, S.; Iqbal, AKM Asif

    2016-02-01

    The increasing demand of fuel efficiency and light weight components in automobile sectors have led to the development of advanced material parts with improved performance. A specific class of MMCs which has gained a lot of attention due to its potential is aluminium metal matrix composites (Al-MMCs). Product performance investigation of Al- MMCs is presented in this article, where an Al-MMCs brake disc is analyzed using finite element analysis. The objective is to identify the potentiality of replacing the conventional iron brake disc with Al-MMCs brake disc. The simulation results suggested that the MMCs brake disc provided better thermal and mechanical performance as compared to the conventional cast iron brake disc. Although, the Al-MMCs brake disc dissipated higher maximum temperature compared to cast iron brake disc's maximum temperature. The Al-MMCs brake disc showed a well distributed temperature than the cast iron brake disc. The high temperature developed at the ring of the disc and heat was dissipated in circumferential direction. Moreover, better thermal dissipation and conduction at brake disc rotor surface played a major influence on the stress. As a comparison, the maximum stress and strain of Al-MMCs brake disc was lower than that induced on the cast iron brake disc.

  10. Evolution of Protoplanetary Discs with Magnetically Driven Disc Winds

    CERN Document Server

    Suzuki, Takeru K; Morbidelli, Alessandro; Crida, Aurélien; Guillot, Tristan

    2016-01-01

    Aims: We investigate the evolution of protoplanetary discs (PPDs hereafter) with magnetically driven disc winds and viscous heating. Methods: We consider an initially massive disc with ~0.1 Msun to track the evolution from the early stage of PPDs. We solve the time evolution of surface density and temperature by taking into account viscous heating and the loss of the mass and the angular momentum by the disc winds within the framework of a standard alpha model for accretion discs. Our model parameters, turbulent viscosity, disc wind mass loss, and disc wind torque, which are adopted from local magnetohydrodynamical simulations and constrained by the global energetics of the gravitational accretion, largely depends on the physical condition of PPDs, particularly on the evolution of the vertical magnetic flux in weakly ionized PPDs. Results: Although there are still uncertainties concerning the evolution of the vertical magnetic flux remaining, surface densities show a large variety, depending on the combinatio...

  11. Renormalization and Induced Gauge Action on a Noncommutative Space

    CERN Document Server

    Grosse, Harald

    2007-01-01

    Field theories on deformed spaces suffer from the IR/UV mxing and renormalization is generically spoiled. In work with R. Wulkenhaar, one of us realized a way to cure this desease by adding one more marginal operator. We review these ideas, show the application to $\\phi^3$ models and use heat kernel expansion methods for a scalar field theory coupled to an external gauge field on a $\\theta$-deformed space and derive noncommutative gauge actions.

  12. Mass transfer between debris discs during close stellar encounters

    CERN Document Server

    Jilkova, Lucie; Hammer, Michael; Zwart, Simon Portegies

    2016-01-01

    We study mass transfers between debris discs during stellar encounters. We carried out numerical simulations of close flybys of two stars, one of which has a disc of planetesimals represented by test particles. We explored the parameter space of the encounters, varying the mass ratio of the two stars, their pericentre and eccentricity of the encounter, and its geometry. We find that particles are transferred to the other star from a restricted radial range in the disc and the limiting radii of this transfer region depend on the parameters of the encounter. We derive an approximate analytic description of the inner radius of the region. The efficiency of the mass transfer generally decreases with increasing encounter pericentre and increasing mass of the star initially possessing the disc. Depending on the parameters of the encounter, the transfer particles have a specific distributions in the space of orbital elements (semimajor axis, eccentricity, inclination, and argument of pericentre) around their new hos...

  13. Counter-Rotating Accretion Discs

    OpenAIRE

    Dyda, Sergei; Lovelace, Richard V. E.; Ustyugova, Galina V.; Romanova, Marina M.; Koldoba, Alexander V.

    2014-01-01

    Counter-rotating discs can arise from the accretion of a counter-rotating gas cloud onto the surface of an existing co-rotating disc or from the counter-rotating gas moving radially inward to the outer edge of an existing disc. At the interface, the two components mix to produce gas or plasma with zero net angular momentum which tends to free-fall towards the disc center. We discuss high-resolution axisymmetric hydrodynamic simulations of a viscous counter-rotating disc for cases where the tw...

  14. Vibration analysis of atomising discs

    Energy Technology Data Exchange (ETDEWEB)

    Deng, H; Ouyang, H, E-mail: H.Ouyang@liverpool.ac.u [Department of Engineering, University of Liverpool, Liverpool L69 3GH (United Kingdom)

    2009-08-01

    The centrifugal atomisation of metallic melts using a spinning disc is an important process for powder production and spray deposition. In the manufacturing process the high-temperature melt flows down to the surface of the atomising disc spinning at very high speed. It is observed that there is a hydraulic jump of the melt flow prior to atomisation. In this paper, the dynamic model of the atomising disc as a spinning Kirchhoff plate with this hydraulic jump is established. The flowing melt is modelled as moving mass and weight force in the radial direction. Using a Galerkin method, it is found that the vibration properties of the atomising disc vary with the disc clamping ratio. The amplitude of the vibration is largely raised when the clamping ratio is smaller than the critical jump radius ratio. It is also found that the disc vibration is non-stationary before becoming steady and the amplitude decreases with increasing disc speed.

  15. Discs in misaligned binary systems

    CERN Document Server

    Rawiraswattana, Krisada; Goodwin, Simon P

    2016-01-01

    We perform SPH simulations to study precession and changes in alignment between the circumprimary disc and the binary orbit in misaligned binary systems. We find that the precession process can be described by the rigid-disc approximation, where the disc is considered as a rigid body interacting with the binary companion only gravitationally. Precession also causes change in alignment between the rotational axis of the disc and the spin axis of the primary star. This type of alignment is of great important for explaining the origin of spin-orbit misaligned planetary systems. However, we find that the rigid-disc approximation fails to describe changes in alignment between the disc and the binary orbit. This is because the alignment process is a consequence of interactions that involve the fluidity of the disc, such as the tidal interaction and the encounter interaction. Furthermore, simulation results show that there are not only alignment processes, which bring the components towards alignment, but also anti-...

  16. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: A meta-analysis of 4600 subjects

    NARCIS (Netherlands)

    F.M.K. Williams (Frances); A.T. Bansal (Aruna); J.B.J. van Meurs (Joyce); J.T. Bell (Jordana); I. Meulenbelt (Ingrid); P. Suri (Pradeep); F. Rivadeneira Ramirez (Fernando); P.N. Sambrook (Philip); A. Hofman (Albert); S.M. Bierma-Zeinstra (Sita); C. Menni (Cristina); M. Kloppenburg (Margreet); P.E. Slagboom (Eline); D. Hunter (David); A.J. MacGregor (Alex ); A.G. Uitterlinden (André); T.D. Spector (Timothy)

    2013-01-01

    textabstractObjective: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide associati

  17. HERO - A 3D general relativistic radiative post-processor for accretion discs around black holes

    Science.gov (United States)

    Zhu, Yucong; Narayan, Ramesh; Sadowski, Aleksander; Psaltis, Dimitrios

    2015-08-01

    HERO (Hybrid Evaluator for Radiative Objects) is a 3D general relativistic radiative transfer code which has been tailored to the problem of analysing radiation from simulations of relativistic accretion discs around black holes. HERO is designed to be used as a post-processor. Given some fixed fluid structure for the disc (i.e. density and velocity as a function of position from a hydrodynamic or magnetohydrodynamic simulation), the code obtains a self-consistent solution for the radiation field and for the gas temperatures using the condition of radiative equilibrium. The novel aspect of HERO is that it combines two techniques: (1) a short-characteristics (SC) solver that quickly converges to a self-consistent disc temperature and radiation field, with (2) a long-characteristics (LC) solver that provides a more accurate solution for the radiation near the photosphere and in the optically thin regions. By combining these two techniques, we gain both the computational speed of SC and the high accuracy of LC. We present tests of HERO on a range of 1D, 2D, and 3D problems in flat space and show that the results agree well with both analytical and benchmark solutions. We also test the ability of the code to handle relativistic problems in curved space. Finally, we discuss the important topic of ray defects, a major limitation of the SC method, and describe our strategy for minimizing the induced error.

  18. Evolution of an accretion disc in binary black hole systems

    Science.gov (United States)

    Kimura, Shigeo S.; Takahashi, Sanemichi Z.; Toma, Kenji

    2017-03-01

    We investigate evolution of an accretion disc in binary black hole (BBH) systems and possible electromagnetic counterparts of the gravitational waves from mergers of BBHs. Perna et al. proposed a novel evolutionary scenario of an accretion disc in BBHs in which a disc eventually becomes 'dead', i.e. the magnetorotational instability (MRI) becomes inactive. In their scenario, the dead disc survives until a few seconds before the merger event. We improve the dead disc model and propose another scenario, taking account of effects of the tidal torque from the companion and the critical ionization degree for MRI activation more carefully. We find that the mass of the dead disc is much lower than that in the Perna's scenario. When the binary separation sufficiently becomes small, the mass inflow induced by the tidal torque reactivates MRI, restarting mass accretion on to the black hole. We also find that this disc 'revival' happens more than thousands of years before the merger. The mass accretion induced by the tidal torque increases as the separation decreases, and a relativistic jet could be launched before the merger. The emissions from these jets are too faint compared to gamma-ray bursts, but detectable if the merger events happen within ≲10 Mpc or if the masses of the black holes are as massive as ∼105 M⊙.

  19. Diverse Electron-Induced Optical Emissions from Space Observatory Materials at Low Temperatures

    Science.gov (United States)

    Dennison, J.R.; Jensen, Amberly Evans; Wilson, Gregory; Dekany, Justin; Bowers, Charles W.; Meloy, Robert

    2013-01-01

    Electron irradiation experiments have investigated the diverse electron-induced optical and electrical signatures observed in ground-based tests of various space observatory materials at low temperature. Three types of light emission were observed: (i); long-duration cathodoluminescence which persisted as long as the electron beam was on (ii) short-duration (affect the performance of space-based observatories.

  20. Cervical Total Disc Arthroplasty

    OpenAIRE

    Basho, Rahul; Hood, Kenneth A.

    2012-01-01

    Symptomatic adjacent segment degeneration of the cervical spine remains problematic for patients and surgeons alike. Despite advances in surgical techniques and instrumentation, the solution remains elusive. Spurred by the success of total joint arthroplasty in hips and knees, surgeons and industry have turned to motion preservation devices in the cervical spine. By preserving motion at the diseased level, the hope is that adjacent segment degeneration can be prevented. Multiple cervical disc...

  1. Accretion Discs in Blazars

    OpenAIRE

    Jolley, E. J. D.; Kuncic, Z.; Bicknell, G. V.; Wagner, S.(Max-Planck-Institut für Kernphysik, 69117, Heidelberg, Germany)

    2009-01-01

    The characteristic properties of blazars (rapid variability, strong polarization, high brightness) are widely attributed to a powerful relativistic jet oriented close to our line of sight. Despite the spectral energy distributions (SEDs) being strongly jet-dominated, a "big blue bump" has been recently detected in sources known as flat spectrum radio quasars (FSRQs). These new data provide a unique opportunity to observationally test coupled jet-disc accretion models in these extreme sources....

  2. Quasi-periodic oscillations in luminous accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Okuda, T.; Mineshige, S. (Cambridge Univ. (UK). Inst. of Astronomy)

    1991-04-15

    We examine the time-dependent evolution of radial pulsational instabilities in luminous accretion discs around neutron stars, using a one-dimensional hydrodynamic code. In geometrically thin and optically thick accretion discs, radial oscillations are overstable to axisymmetric perturbations. It is due to a mechanism similar to the {epsilon} mechanism in stellar pulsation. We find that this instability induces large amplitude oscillations (more than 100 per cent) in accretion rates and small modulations (a few per cent) in temperature and surface in the inner part of the disc, both with local Keplerian frequencies. (author).

  3. Apsidal precession, disc breaking and viscosity in warped discs

    CERN Document Server

    Nealon, Rebecca; Price, Daniel J; King, Andrew

    2015-01-01

    We demonstrate the importance of general relativistic apsidal precession in warped black hole accretion discs by comparing three - dimensional smoothed particle hydrodynamic simulations in which this effect is first neglected, and then included. If apsidal precession is neglected, we confirm the results of an earlier magnetohydrodynamic simulation which made this assumption, showing that at least in this case the $\\alpha$ viscosity model produces very similar results to those of simulations where angular momentum transport is due to the magnetorotational instability. Including apsidal precession significantly changes the predicted disc evolution. For moderately inclined discs thick enough that tilt is transported by bending waves, we find a disc tilt which is nonzero at the inner disc edge and oscillates with radius, consistent with published analytic results. For larger inclinations we find disc breaking.

  4. Mechanics of Actuated Disc Cutting

    Science.gov (United States)

    Dehkhoda, Sevda; Detournay, Emmanuel

    2017-02-01

    This paper investigates the mechanics of an actuated disc cutter with the objective of determining the average forces acting on the disc as a function of the parameters characterizing its motion. The specific problem considered is that of a disc cutter revolving off-centrically at constant angular velocity around a secondary axis rigidly attached to a cartridge, which is moving at constant velocity and undercutting rock at a constant depth. This model represents an idealization of a technology that has been implemented in a number of hard rock mechanical excavators with the goal of reducing the average thrust force to be provided by the excavation equipment. By assuming perfect conformance of the rock with the actuated disc as well as a prescribed motion of the disc (perfectly rigid machine), the evolution of the contact surface between the disc and the rock during one actuation of the disc can be computed. Coupled with simple cutter/rock interaction models that embody either a ductile or a brittle mode of fragmentation, these kinematical considerations lead to an estimate of the average force on the cartridge and of the partitioning of the energy imparted by the disc to the rock between the actuation mechanism of the disc and the translation of the cartridge on which the actuated disc is attached.

  5. Eclipse Mapping: Astrotomography of Accretion Discs

    Science.gov (United States)

    Baptista, Raymundo

    The Eclipse Mapping Method is an indirect imaging technique that transforms the shape of the eclipse light curve into a map of the surface brightness distribution of the occulted regions. Three decades of application of this technique to the investigation of the structure, the spectrum and the time evolution of accretion discs around white dwarfs in cataclysmic variables have enriched our understanding of these accretion devices with a wealth of details such as (but not limited to) moving heating/cooling waves during outbursts in dwarf novae, tidally-induced spiral shocks of emitting gas with sub-Keplerian velocities, elliptical precessing discs associated to superhumps, and measurements of the radial run of the disc viscosity through the mapping of the disc flickering sources. This chapter reviews the principles of the method, discusses its performance, limitations, useful error propagation procedures, as well as highlights a selection of applications aimed at showing the possible scientific problems that have been and may be addresses with it.

  6. Genomic and proteomic analysis of soybean heritable variations induced by space flight

    Institute of Scientific and Technical Information of China (English)

    HE Jie; GAO Yong; SUN Ye-qing

    2009-01-01

    To analyze the biological effects of space environment, the diversity of genomic DNA between the space flight soybean 194(4126) with phenotype of good yield and good fruit quality induced by space flight and the soybean with ground control was studied by amplified fragment length polymorphism (AFLP) method, and the polymorphism of space flight soybean 194(4126) was 3.56%. The differences of protein expression of seeds and leaves between the two kinds of soybeans were analysed by two-dimensional electrophoresis, PDQuest software and MALDI-TOF mass spectrometry. Results show that the loss and decrease of protein expression in 194(4126) soybean are subjected to the space fight of seeds, and three special proteins including Dehydrin, MAT1 and ceQORH are identified. It is concluded that the space environment changes the phenotype and geno-type of soybeans due to the space flight of seeds.

  7. Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T

    Energy Technology Data Exchange (ETDEWEB)

    Trattnig, Siegfried [Medical University of Vienna, Department of Radiology, MR Centre-Highfield MR, Vienna (Austria); Ludwig Boltzmann Institute for Clinical and Experimental Traumatology, Austrian Cluster for Tissue Regeneration, Vienna (Austria); Stelzeneder, David; Goed, Sabine; Reissegger, Michael [Medical University of Vienna, Department of Radiology, MR Centre-Highfield MR, Vienna (Austria); Mamisch, Tallal C. [Inselspital Berne, Orthopedic Surgery Department, Berne (Switzerland); Paternostro-Sluga, Tatjana [Medical University of Vienna, Department of Physical Medicine and Rehabilitation, Vienna (Austria); Weber, Michael [Medical University of Vienna, Department of Radiology, Vienna (Austria); Szomolanyi, Pavol [Medical University of Vienna, Department of Radiology, MR Centre-Highfield MR, Vienna (Austria); Slovak Academy of Sciences, Department of Imaging Methods, Institute of Measurement Science, Bratislava (Slovakia); Welsch, Goetz H. [Medical University of Vienna, Department of Radiology, MR Centre-Highfield MR, Vienna (Austria); University Hospital of Erlangen, Department of Trauma Surgery, Erlangen (Germany)

    2010-11-15

    To assess the relationship of morphologically defined lumbar disc abnormalities with quantitative T2 mapping. Fifty-three patients, mean age 39 years, with low back pain were examined by MRI at 3 T (sagittal T1-fast spin echo (FSE), three-plane T2-FSE for morphological MRI, multi-echo spin echo for T2 mapping). All discs were classified morphologically. Regions of interest (ROIs) for the annulus were drawn. The space in between was defined as the nucleus pulposus (NP). To evaluate differences between the classified groups, univariate ANOVA with post hoc Games-Howell and paired two-tailed t tests were used. In 265 discs we found 39 focal herniations, 10 annular tears, 123 bulging discs and 103 ''normal discs''. T2 values of the NP between discs with annular tear and all other groups were statistically significantly different (all p {<=} 0.01). Discs with annular tears showed markedly lower NP T2 values than discs without. The difference in NP T2 values between discs with focal herniation and normal discs (p = 0.005) was statistically significant. There was no difference in NP T2 values between bulging and herniated discs (p = 0.11) Quantitative T2 mapping of the nucleus pulposus of the intervertebral disc in the lumbar spine at 3 T reveals significant differences in discs with herniation and annular tears compared with discs without these abnormalities. (orig.)

  8. Queixas auditivas de disc jockeys da cidade de Recife Auditory complaints in disc jockeys in Recife

    Directory of Open Access Journals (Sweden)

    Eliza Maia de Britto Macedo

    2011-06-01

    , involving occupational information, general knowledge about noise and auditory complaints (diminished auditory acuity, discomfort under intense sound, tinnitus, sultry ear sensation and otalgia. The analysis was carried out through a quantitative approach and using t-student statistical test. RESULTS: among the most relevant data we can empathize that: 46.7% of the disc jockeys showed, spontaneously, auditory complaints, in special, reduction of the auditory acuity (referred by all subjects; 14 disc jockeys (46.67% related to feel discomfort to intense sound and 13 (43.33% mentioned tinnitus. All of them affirmed to know the risks of noise related to auditory health, but 76.7% do not apply any prevention against its consequences. Hearing loss was related as the main risk of exposure to high level of sound pressure. CONCLUSIONS: all disc jockeys complained on hearing loss and, among the other auditory complaints, we may emphasize discomfort under intense sound and tinnitus. Considering the irreversibility of high sound pressure induced hearing loss, the disc jockeys might be periodically evaluated as for hearing in order to confirm or discard the hearing loss they complaint. If hearing loss exist, it might be monitored, in order to make possible an intervention by the speech-language therapist. Such being the case, we may perceive the need for speech therapy concerning the disc jockeys for optimizing their professional performance with less risks.

  9. Stochastic Wobble of Accretion Discs and Jets from Turbulent Rocket Torques

    CERN Document Server

    Pettibone, Ryan

    2008-01-01

    Models of accretion discs and their associated outflows often incorporate assumptions of axisymmetry and symmetry across the disc plane. However, because discs are likely turbulent, these symmetries do not apply locally. The local asymmetry may induce local imbalances in outflow power across the disc mid-plane, which can in turn induce local tilting torques. Here we calculate the effect of the resulting stochastic torques on disc annuli. The torques induce a random walk of the vector perpendicular to the plane of each averaged annulus. This random walk is characterized by a radially dependent diffusion coefficient. We calculate the diffusion coefficient for small angle tilt and use it to obtain a radially dependent time scale for annular tilt and associated jet wobble. To be relevant, the tilt time scale must be less than the disc age, which favors binary accretion systems due to the prolonged mass supply. Accordingly, in crudely applying our results to blazars, young stellar objects and the binary engines of...

  10. Heat distribution in disc brake

    Science.gov (United States)

    Klimenda, Frantisek; Soukup, Josef; Kampo, Jan

    2016-06-01

    This article is deals by the thermal analysis of the disc brake with floating caliper. The issue is solved by numerically. The half 2D model is used for solution in program ADINA 8.8. Two brake discs without the ventilation are solved. One disc is made from cast iron and the second is made from stainless steel. Both materials are an isotropic. By acting the pressure force on the brake pads will be pressing the pads to the brake disc. Speed will be reduced (slowing down). On the contact surface generates the heat, which the disc and pads heats. In the next part of article is comparison the maximum temperature at the time of braking. The temperatures of both materials for brake disc (gray cast iron, stainless steel) are compares. The heat flux during braking for the both materials is shown.

  11. Phase diagram of mixtures of hard colloidal spheres and discs: A free-volume scaled-particle approach

    NARCIS (Netherlands)

    Lekkerkerker, H.N.W.; Oversteegen, S.M.

    2004-01-01

    Phase diagrams of mixtures of colloidal hard spheres with hard discs are calculated by means of the free-volume theory. The free-volume fraction available to the discs is determined from scaled-particle theory. The calculations show that depletion induced phase separation should occur at low disc co

  12. Phase diagram of mixtures of hard colloidal spheres and discs: A free-volume scaled-particle approach

    NARCIS (Netherlands)

    Lekkerkerker, H.N.W.; Oversteegen, S.M.

    2004-01-01

    Phase diagrams of mixtures of colloidal hard spheres with hard discs are calculated by means of the free-volume theory. The free-volume fraction available to the discs is determined from scaled-particle theory. The calculations show that depletion induced phase separation should occur at low disc

  13. Dynamics of warped accretion discs

    OpenAIRE

    Tremaine, Scott; Davis, Shane W.

    2013-01-01

    Accretion discs are present around both stellar-mass black holes in X-ray binaries and supermassive black holes in active galactic nuclei. A wide variety of circumstantial evidence implies that many of these discs are warped. The standard Bardeen--Petterson model attributes the shape of the warp to the competition between Lense--Thirring torque from the central black hole and viscous angular-momentum transport within the disc. We show that this description is incomplete, and that torques from...

  14. Numbered nasal discs for waterfowl

    Science.gov (United States)

    Bartonek, J.C.; Dane, C.W.

    1964-01-01

    Numbered nasal discs were successfully used in studies requiring large numbers of individually marked waterfowl. The procedure for constructing these discs is outlined. Blue-winged teal (Anas discors) with 5/8-inch discs, and canvasback (Aythya valisineria) and redhead (A. americana) with 3/4-inch discs can be individually identified up to 50 and 80 yards, respectively, with a gunstock-mounted, 20-power spotting scope. The particular value of these markers is their durability, the number of combinations possible, and the apparent absence of behavioral or mortality influence among such species as the blue-winged teal.

  15. A Dark Matter Disc in the Milky Way

    Science.gov (United States)

    Read, J. I.; Bruch, T.; Baudis, L.; Debattista, V. P.; Agertz, O.; Mayer, L.; Brooks, A. M.; Governato, F.; Peter, A. H. G.; Lake, G.

    2010-06-01

    Dark matter direct detection experiments need to know the local phase space density of dark matter fdm(r,v,t) in order to derive dark matter particle properties. To date, calculations for fdm(r,v,t) have been based on simulations that model the dark matter alone. Here we include the influence of the baryonic matter. We find that a star/gas disc at high redshift (z~1) causes merging satellites to be preferentially dragged towards the disc plane. This results in an accreted dark matter disc that contributes ~0.25-1 times the non-rotating halo density at the Solar position. We discuss the impact of the dark disc on dark matter direct detection experiments, and how we might be able to detect it in future Galactic surveys.

  16. A truly Newtonian softening length for disc simulations

    CERN Document Server

    Huré, Jean-Marc

    2014-01-01

    The softened point mass model is commonly used in simulations of gaseous discs including self-gravity while the value of associated length \\lambda remains, to some degree, controversial. This ``parameter'' is however fully constrained when, in a discretized disc, all fluid cells are demanded to obey Newton's law. We examine the topology of solutions in this context, focusing on cylindrical cells more or less vertically elongated. We find that not only the nominal length depends critically on the cell's shape (curvature, radial extension, height), but it is either a real or an imaginary number. Setting \\lambda as a fraction of the local disc thickness -- as usually done -- is indeed not the optimal choice. We then propose a novel prescription valid irrespective of the disc properties and grid spacings. The benefit, which amounts to 2-3 more digits typically, is illustrated in a few concrete cases. A detailed mathematical analysis is in progress.

  17. 烟酰胺对压力诱发免腰椎间盘退变的保护作用%Protective effects of Niacinamide against axial loading induced degeneration of rabbit lumbar disc

    Institute of Scientific and Technical Information of China (English)

    周建国; 杨述华; 杨操; 邵增务; 徐蔚蔚; 郭兵; 俞旭东; 熊蠡茗

    2009-01-01

    的椎间盘恢复.%BACKGROUND:Recent studies have demonstrated that Niacinamide is capable of promoting the proliferation of intervertebral cells and improving intervertebral disc degeneration.Overloading is thought to the main cause of intervertebral disc degeneration.However,the protective effects of Niacinamide in loading induced intervertebral disc degeneration remains uncertain,OBJECTIVE:To investigate the protective effects of Niacinamide against axial loading induced degeneration of rabbit lumbar disc.DESIGN,TIME AND SETTING:A randomized controlled experiment was carded out in the Central Laboratory and the Laboratory of Department of Orthopaedics,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology from November 2008 to April 2009.MATERIALS:Twenty-four Japanese white rabbits (4 months old,weighing 2.0 kg).Niacinamide was supplied by Tianjin Damao Chemical Reagent Factory.METHODS:Twenty-four Japanese white rabbits were randomly divided into 6 groups.The controllable axial loading induced rabbit lumbar disc degeneration model was adopted to impose 98N pressure on the rabbit discs to induce degeneration.Various doses of Niacinamide were given intragastrically to the rabbits in different groups:2 rabbits in group 1,the loading device was installed without pressing,and no Niacinamide was given;2 rabbits in group 2,given 50 mg/kg Niacinamide for 1 week;5 rabbits in group 3,loaded with 98N for 1 week;5 rabbits in group 4,loaded with 98N for 1 week,then the pressure was released for another week's recovery;5 rabbits in group 5,loaded with 98N and given 50 mg/kg Niacinamide for 1 week;5 rabbits in group 6,loaded with 98N for 1 week and then the pressure was released for another week's recovery,50 mg/kg Niacinamide was continually given during the 2 weeks.MAIN OUTCOME MEASURES:Magnetic resonance image and Thompson's grading system were used to assess degeneration degree of the discs;hematoxylin and eosin staining,immunohistochemical staining for type Ⅱ collagen

  18. Optic disc drusen

    DEFF Research Database (Denmark)

    Fledelius, Hans C

    2017-01-01

    PURPOSE: To examine long-term data on optic disc drusen (ODD) from an outpatient hospital series that indicated more cases with advanced visual field constriction than is apparent from other clinical reports. The underlying pathophysiology is discussed, also with regard to enlarged blind spot...... neurosurgery for an arachnoid cyst. CONCLUSIONS: We found more cases of marked visual field constriction than reported in other clinical series. A few such cases appeared acute and vascular, but the main trend was clinically quiet over time. All 49 patients could manage visually in daily life....

  19. [Temporomandibular joint disc surgery].

    Science.gov (United States)

    Potier, J; Maes, J-M; Nicot, R; Dumousseau, T; Cotelle, M; Ferri, J

    2016-09-01

    Temporomandibular joint (TMJ) disorders are a common disease and may be responsible for major functional and painful repercussions. Treatment is not consensual. The literature highlights the role of conservative treatments (physiotherapy, analgesics, splints) in a first attempt. Minimally invasive surgical techniques (arthroscopy, arthrocentesis) have developed rapidly in recent decades. They have proven effective and reliable, especially in patients suffering from irreducible or reducible anterior disc dislocation or presenting with arthopathies. The goal of our work was to make an update about disk surgery. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. Relativistic Disc lines

    CERN Document Server

    Fabian, A C; Parker, M L

    2014-01-01

    Broad emission lines, particularly broad iron-K lines, are now commonly seen in the X-ray spectra of luminous AGN and Galactic black hole binaries. Sensitive NuSTAR spectra over the energy range of 3-78 keV and high frequency reverberation spectra now confirm that these are relativistic disc lines produced by coronal irradiation of the innermost accretion flow around rapidly spinning black holes. General relativistic effects are essential in explaining the observations. Recent results are briefly reviewed here.

  1. Use of Temporary Implantable Biomaterials to Reduce Leg Pain and Back Pain in Patients with Sciatica and Lumbar Disc Herniation

    Directory of Open Access Journals (Sweden)

    Gere S. diZerega

    2010-05-01

    Full Text Available The principle etiology of leg pain (sciatica from lumbar disc herniation is mechanical compression of the nerve root. Sciatica is reduced by decompression of the herniated disc, i.e., removing mechanical compression of the nerve root. Decompression surgery typically reduces sciatica more than lumbar back pain (LBP. Decompression surgery reduces mechanical compression of the nerve root. However, decompression surgery does not directly reduce sensitization of the sensory nerves in the epidural space and disc. In addition, sensory nerves in the annulus fibrosus and epidural space are not protected from topical interaction with pain mediators induced by decompression surgery. The secondary etiology of sciatica from lumbar disc herniation is sensitization of the nerve root. Sensitization of the nerve root results from a mechanical compression, b exposure to cellular pain mediators, and/or c exposure to biochemical pain mediators. Although decompression surgery reduces nerve root compression, sensory nerve sensitization often persists. These observations are consistent with continued exposure of tissue in the epidural space, including the nerve root, to increased cellular and biochemical pain mediators following surgery. A potential contributor to lumbar back pain (LBP is stimulation of sensory nerves in the annulus fibrosus by a cellular pain mediators and/or b biochemical pain mediators that accompany annular tears or disruption. Sensory fibers located in the outer one-third of the annulus fibrosus increase in number and depth as a result of disc herniation. The nucleus pulposus is comprised of material that can produce an autoimmune stimulation of the sensory nerves located in the annulus and epidural space leading to LBP. The sensory nerves of the annulus fibrosus and epidural space may be sensitized by topical exposure to cellular and biochemical pain mediators induced by lumbar surgery. Annulotomy or annular rupture allows the nucleus pulposus

  2. Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats

    Energy Technology Data Exchange (ETDEWEB)

    Issy, A.C.; Castania, V.; Castania, M. [Departamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Salmon, C.E.G. [Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Nogueira-Barbosa, M.H. [Divisão de Radiologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Bel, E. Del [Departamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Defino, H.L.A. [Departamento de Biomecânica, Medicina e Reabilitação do Sistema Locomotor, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2013-03-15

    Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and histological evaluation. Adult male Wistar rats were anesthetized and submitted to percutaneous disc puncture with a 20-gauge needle on levels 6-7 and 8-9 of the coccygeal vertebrae. The needle was inserted into the discs guided by fluoroscopy and its tip was positioned crossing the nucleus pulposus up to the contralateral annulus fibrosus, rotated 360° twice, and held for 30 s. To grade the severity of intervertebral disc degeneration, we measured the intervertebral disc height from radiographic images 7 and 30 days after the injury, and the signal intensity T2-weighted magnetic resonance imaging. Histological analysis was performed with hematoxylin-eosin and collagen fiber orientation using picrosirius red staining and polarized light microscopy. Imaging and histological score analyses revealed significant disc degeneration both 7 and 30 days after the lesion, without deaths or systemic complications. Interobserver histological evaluation showed significant agreement. There was a significant positive correlation between histological score and intervertebral disc height 7 and 30 days after the lesion. We conclude that the tail disc puncture method using Wistar rats is a simple, cost-effective and reproducible model for inducing disc degeneration.

  3. Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats

    Directory of Open Access Journals (Sweden)

    A.C. Issy

    Full Text Available Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and histological evaluation. Adult male Wistar rats were anesthetized and submitted to percutaneous disc puncture with a 20-gauge needle on levels 6-7 and 8-9 of the coccygeal vertebrae. The needle was inserted into the discs guided by fluoroscopy and its tip was positioned crossing the nucleus pulposus up to the contralateral annulus fibrosus, rotated 360° twice, and held for 30 s. To grade the severity of intervertebral disc degeneration, we measured the intervertebral disc height from radiographic images 7 and 30 days after the injury, and the signal intensity T2-weighted magnetic resonance imaging. Histological analysis was performed with hematoxylin-eosin and collagen fiber orientation using picrosirius red staining and polarized light microscopy. Imaging and histological score analyses revealed significant disc degeneration both 7 and 30 days after the lesion, without deaths or systemic complications. Interobserver histological evaluation showed significant agreement. There was a significant positive correlation between histological score and intervertebral disc height 7 and 30 days after the lesion. We conclude that the tail disc puncture method using Wistar rats is a simple, cost-effective and reproducible model for inducing disc degeneration.

  4. Laser-Induced Linear Electron Acceleration in Free Space

    CERN Document Server

    Wong, Liang Jie; Carbajo, Sergio; Fallahi, Arya; Soljačić, Marin; Joannopoulos, John D; Kärtner, Franz X; Kaminer, Ido

    2016-01-01

    Linear acceleration in free space is a topic that has been studied for over 20 years, and its ability to eventually produce high-quality, high energy multi-particle bunches has remained a subject of great interest. Arguments can certainly be made that such an ability is very doubtful. Nevertheless, we chose to develop an accurate and truly predictive theoretical formalism to explore this remote possibility in a computational experiment. The formalism includes exact treatment of Maxwell's equations, exact relativistic treatment of the interaction among the multiple individual particles, and exact treatment of the interaction at near and far field. Several surprising results emerged. For example, we find that 30 keV electrons (2.5% energy spread) can be accelerated to 7.7 MeV (2.5% spread) and to 205 MeV (0.25% spread) using 25 mJ and 2.5 J lasers respectively. These findings should hopefully guide and help develop compact, high-quality, ultra-relativistic electron sources, avoiding conventional limits imposed ...

  5. Alignment in star-debris disc systems seen by Herschel

    CERN Document Server

    Greaves, J S; Thureau, N; Eiroa, C; Marshall, J P; Maldonado, J; Matthews, B C; Olofsson, G; Barlow, M J; Moro-Martin, A; Sibthorpe, B; Absil, O; Ardila, D R; Booth, M; Broekhoven-Fiene, H; Brown, D J A; Cameron, A Collier; del Burgo, C; Di Francesco, J; Duchene, G; Eisloffel, J; Ertel, S; Holland, W S; Horner, J; Kalas, P; Kavelaars, J J; Lestrade, J -F; Vican, L; Wilner, D J; Wolf, S; Wyatt, M C

    2013-01-01

    Many nearby main-sequence stars have been searched for debris using the far-infrared Herschel satellite, within the DEBRIS, DUNES and Guaranteed-Time Key Projects. We discuss here 11 stars of spectral types A to M where the stellar inclination is known and can be compared to that of the spatially-resolved dust belts. The discs are found to be well aligned with the stellar equators, as in the case of the Sun's Kuiper belt, and unlike many close-in planets seen in transit surveys. The ensemble of stars here can be fitted with a star-disc tilt of ~<10 degrees. These results suggest that proposed mechanisms for tilting the star or disc in fact operate rarely. A few systems also host imaged planets, whose orbits at tens of AU are aligned with the debris discs, contrary to what might be expected in models where external perturbers induce tilts.

  6. Alignment in star-debris disc systems seen by Herschel

    Science.gov (United States)

    Greaves, J. S.; Kennedy, G. M.; Thureau, N.; Eiroa, C.; Marshall, J. P.; Maldonado, J.; Matthews, B. C.; Olofsson, G.; Barlow, M. J.; Moro-Martín, A.; Sibthorpe, B.; Absil, O.; Ardila, D. R.; Booth, M.; Broekhoven-Fiene, H.; Brown, D. J. A.; Cameron, A. Collier; del Burgo, C.; Di Francesco, J.; Eislöffel, J.; Duchêne, G.; Ertel, S.; Holland, W. S.; Horner, J.; Kalas, P.; Kavelaars, J. J.; Lestrade, J.-F.; Vican, L.; Wilner, D. J.; Wolf, S.; Wyatt, M. C.

    2014-02-01

    Many nearby main-sequence stars have been searched for debris using the far-infrared Herschel satellite, within the DEBRIS, DUNES and Guaranteed-Time Key Projects. We discuss here 11 stars of spectral types A-M where the stellar inclination is known and can be compared to that of the spatially resolved dust belts. The discs are found to be well aligned with the stellar equators, as in the case of the Sun's Kuiper belt, and unlike many close-in planets seen in transit surveys. The ensemble of stars here can be fitted with a star-disc tilt of ≲ 10°. These results suggest that proposed mechanisms for tilting the star or disc in fact operate rarely. A few systems also host imaged planets, whose orbits at tens of au are aligned with the debris discs, contrary to what might be expected in models where external perturbers induce tilts.

  7. Accretion discs trapped near corotation

    NARCIS (Netherlands)

    D'Angelo, C.R.; Spruit, H.C.

    2012-01-01

    We show that discs accreting on to the magnetosphere of a rotating star can end up in a trapped state, in which the inner edge of the disc stays near the corotation radius, even at low and varying accretion rates. The accretion in these trapped states can be steady or cyclic; we explore these states

  8. Comparison of ripening processes in intact tomato fruit and excised pericarp discs.

    Science.gov (United States)

    Campbell, A D; Huysamer, M; Stotz, H U; Greve, L C; Labavitch, J M

    1990-12-01

    Physiological processes characteristic of ripening in tissues of intact tomato fruit (Lycopersicon esculentum Mill.) were examined in excised pericarp discs. Pericarp discs were prepared from mature-green tomato fruit and stored in 24-well culture plates, in which individual discs could be monitored for color change, ethylene biosynthesis, and respiration, and selected for cell wall analysis. Within the context of these preparation and handling procedures, most whole fruit ripening processes were maintained in pericarp discs. Pericarp discs and matched intact fruit passed through the same skin color stages at similar rates, as expressed in the L(*)a(*)b(*) color space, changing from green (a(*) red (a(*) > 15) in about 6 days. Individual tissues of the pericarp discs changed color in the same sequence seen in intact fruit (exocarp, endocarp, then vascular parenchyma). Discs from different areas changed in the same spatial sequence seen in intact fruit (bottom, middle, top). Pericarp discs exhibited climacteric increases in ethylene biosynthesis and CO(2) production comparable with those seen in intact fruit, but these were more tightly linked to rate of color change, reaching a peak around a(*) = 5. Tomato pericarp discs decreased in firmness as color changed. Cell wall carbohydrate composition changed with color as in intact fruit: the quantity of water-soluble pectin eluted from the starch-free alcohol insoluble substances steadily increased and more tightly bound, water-insoluble, pectin decreased in inverse relationship. The cell wall content of the neutral sugars arabinose, rhamnose, and galactose steadily decreased as color changed. The extractable activity of specific cell wall hydrolases changed as in intact fruit: polygalacturonase activity, not detectable in green discs (a(*) = -5), appeared as discs turned yellow-red (a(*) = 5), and increased another eight-fold as discs became full red (a(*) value +20). Carboxymethyl-cellulase activity, low in extracts

  9. Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments

    Science.gov (United States)

    Wang, Jian; Zhang, Xiangming; Wang, Ping; Wang, Xiang; Farris, Alton B.; Wang, Ya

    2016-06-01

    Unlike terrestrial ionizing radiation, space radiation, especially galactic cosmic rays (GCR), contains high energy charged (HZE) particles with high linear energy transfer (LET). Due to a lack of epidemiologic data for high-LET radiation exposure, it is highly uncertain how high the carcinogenesis risk is for astronauts following exposure to space radiation during space missions. Therefore, using mouse models is necessary to evaluate the risk of space radiation-induced tumorigenesis; however, which mouse model is better for these studies remains uncertain. Since lung tumorigenesis is the leading cause of cancer death among both men and women, and low-LET radiation exposure increases human lung carcinogenesis, evaluating space radiation-induced lung tumorigenesis is critical to enable safe Mars missions. Here, by comparing lung tumorigenesis obtained from different mouse strains, as well as miR-21 in lung tissue/tumors and serum, we believe that wild type mice with a low spontaneous tumorigenesis background are ideal for evaluating the risk of space radiation-induced lung tumorigenesis, and circulating miR-21 from such mice model might be used as a biomarker for predicting the risk.

  10. Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments.

    Science.gov (United States)

    Wang, Jian; Zhang, Xiangming; Wang, Ping; Wang, Xiang; Farris, Alton B; Wang, Ya

    2016-06-01

    Unlike terrestrial ionizing radiation, space radiation, especially galactic cosmic rays (GCR), contains high energy charged (HZE) particles with high linear energy transfer (LET). Due to a lack of epidemiologic data for high-LET radiation exposure, it is highly uncertain how high the carcinogenesis risk is for astronauts following exposure to space radiation during space missions. Therefore, using mouse models is necessary to evaluate the risk of space radiation-induced tumorigenesis; however, which mouse model is better for these studies remains uncertain. Since lung tumorigenesis is the leading cause of cancer death among both men and women, and low-LET radiation exposure increases human lung carcinogenesis, evaluating space radiation-induced lung tumorigenesis is critical to enable safe Mars missions. Here, by comparing lung tumorigenesis obtained from different mouse strains, as well as miR-21 in lung tissue/tumors and serum, we believe that wild type mice with a low spontaneous tumorigenesis background are ideal for evaluating the risk of space radiation-induced lung tumorigenesis, and circulating miR-21 from such mice model might be used as a biomarker for predicting the risk.

  11. Intraoral micro-identification discs.

    Science.gov (United States)

    Hansen, R W

    1991-12-01

    Intraoral micro-identification discs have recently been utilized to provide a more permanent method of personal identification. A wafer of plastic or metal with a surface area of 2.5 to 5 mm2 and carrying identifying numbers and/or letters (indicia) is bonded to the buccal enamel surface of the posterior teeth. Personal identification can occur after the I.D. disc is identified and the indicia is read. Reading of photoreduced indicia requires the aid of a microscope subsequent to the removal of the microdisc. In situ reading of disc indicia is possible using low power handheld magnifiers if the size of the indicia approximates 0.3 mm. Computerization is an integral part of non-custom alpha/numeric type designs, but a custom disc carries a name, address, and other specific information unique to the manufacturer. The use of a computer improves access to the database and it decreases the amount of data placed on the disc. Microdisc bases may be fabricated using a mylar type plastic or they may be manufactured from a stainless steel blank. Plastic discs are constructed with an internal sandwich containing the photo-reduced indicia. Metal discs are marked with a photochemical etch or engraved with a computer driven YAG laser. Attachment of the disc to the enamel surface is accomplished by conventional etching and bonding techniques and are typically bonded to the buccal surface of the maxillary first permanent molar or the second primary molar. Clear composite bonding material covers the disc so that salivary contamination does not result in degradation of the indicia. Orthodontic style discs with a mesh back carry laser written information that may be cemented with conventional orthodontic bonding cement. Standardization of the indicia and overall design is considered to be an important aspect of patient and professional acceptance.

  12. Evolution of protoplanetary discs with magnetically driven disc winds

    Science.gov (United States)

    Suzuki, Takeru K.; Ogihara, Masahiro; Morbidelli, Alessandro; Crida, Aurélien; Guillot, Tristan

    2016-12-01

    Aims: We investigate the evolution of protoplanetary discs (PPDs) with magnetically driven disc winds and viscous heating. Methods: We considered an initially massive disc with 0.1 M⊙ to track the evolution from the early stage of PPDs. We solved the time evolution of surface density and temperature by taking into account viscous heating and the loss of mass and angular momentum by the disc winds within the framework of a standard α model for accretion discs. Our model parameters, turbulent viscosity, disc wind mass-loss, and disc wind torque, which were adopted from local magnetohydrodynamical simulations and constrained by the global energetics of the gravitational accretion, largely depends on the physical condition of PPDs, particularly on the evolution of the vertical magnetic flux in weakly ionized PPDs. Results: Although there are still uncertainties concerning the evolution of the vertical magnetic flux that remains, the surface densities show a large variety, depending on the combination of these three parameters, some of which are very different from the surface density expected from the standard accretion. When a PPD is in a wind-driven accretion state with the preserved vertical magnetic field, the radial dependence of the surface density can be positive in the inner region migration of protoplanets. Conclusions: The variety of our calculated PPDs should yield a wide variety of exoplanet systems.

  13. Research on Heat-Mechanical Coupling of Ventilated Disc Brakes under the Condition of Emergency Braking

    Science.gov (United States)

    Tan, Xuelong; Zhang, Jian; Tang, Wenxian; Zhang, Yang

    Taking the ventilated disc brake in some company as research object, and using UG to build 3D models of brake disc and pad, and making use of ABAQUS/Standard to set up two parts' finite element model, via the decelerated motion of actual simulation brake disc, which gets ventilated disc brake in the case of emergency breaking in time and space distribution of conditions of temperature and stress field, summarizes the distribution of temperature field and stress field, proves complex coupling between temperature, stress, and supplies the direct basis for brake's fatigue life analysis.

  14. Gas in Protoplanetary Discs (GASPS) 1. First results

    CERN Document Server

    Mathews, G S; Williams, J P; Howard, C D; Meeus, G; Riaz, B; Roberge, A; Sandell, G; Vandenbussche, B; Duchêne, G; Kamp, I; Ménard, F; Montesinos, B; Pinte, C; Thi, W F; Woitke, P; Alacid, J M; Andrews, S M; Ardila, D R; Aresu, G; Augereau, J C; Barrado, D; Brittain, S; Ciardi, D R; Danchi, W; Eiroa, C; Fedele, D; Grady, C A; de Gregorio-Monsalvo, I; Heras, A; Huelamo, N; Krivov, A; Lebreton, J; Liseau, R; Martin-Zaidi, C; Mendigutía, I; Mora, A; Morales-Calderon, M; Nomura, H; Pantin, E; Pascucci, I; Phillips, N; Podio, L; Poelman, D R; Ramsay, S; Rice, K; Riviere-Marichalar, P; Solano, E; Tilling, I; Walker, H; White, G J; Wright, G

    2010-01-01

    Context - Circumstellar discs are ubiquitous around young stars, but rapidly dissipate their gas and dust on timescales of a few Myr. The Herschel space observatory allows for the study of the warm disc atmosphere, using far-infrared spectroscopy to measure gas content and excitation conditions, and far-IR photometry to constrain the dust distribution. Aims - We aim to detect and characterize the gas content of circumstellar discs in four targets as part of the Herschel science demonstration phase. Methods - We carried out sensitive medium resolution spectroscopy and high sensitivity photometry at lambda ~60-190 micron using the Photodetector Array Camera and Spectrometer instrument on the Herschel space observatory. Results - We detect [OI] 63 micron emission from the young stars HD 169142, TW Hydrae, and RECX 15, but not HD 181327. No other lines, including [CII] 158 and [OI] 145, are significantly detected. All four stars are detected in photometry at 70 and 160 micron. Extensive models are presented in as...

  15. Coevolution of Binaries and Gaseous Discs

    CERN Document Server

    Fleming, David P

    2016-01-01

    The recent discoveries of circumbinary planets by $\\it Kepler$ raise questions for contemporary planet formation models. Understanding how these planets form requires characterizing their formation environment, the circumbinary protoplanetary disc, and how the disc and binary interact and change as a result. The central binary excites resonances in the surrounding protoplanetary disc that drive evolution in both the binary orbital elements and in the disc. To probe how these interactions impact binary eccentricity and disc structure evolution, N-body smooth particle hydrodynamics (SPH) simulations of gaseous protoplanetary discs surrounding binaries based on Kepler 38 were run for $10^4$ binary periods for several initial binary eccentricities. We find that nearly circular binaries weakly couple to the disc via a parametric instability and excite disc eccentricity growth. Eccentric binaries strongly couple to the disc causing eccentricity growth for both the disc and binary. Discs around sufficiently eccentri...

  16. Disc displacement patterns in lumbar anterior spondylolisthesis: Contribution to foraminal stenosis

    Energy Technology Data Exchange (ETDEWEB)

    MacMahon, P.J. [Department of Radiology, Cappagh National Orthopaedic Hospital, Finglas, Dublin 11 (Ireland)], E-mail: petermacmahon@yahoo.com; Taylor, D.H.; Duke, D.; Brennan, D.D.; Eustace, S.J. [Department of Radiology, Cappagh National Orthopaedic Hospital, Finglas, Dublin 11 (Ireland)

    2009-04-15

    Purpose: To describe the particular disc displacement pattern seen at MRI in patients with spondylolisthesis, and its potential contribution to foraminal stenosis. Methods: 38 patients with symptomatic lumbar anterior spondylolisthesis and 38 sex and aged matched control patients with herniated disc disease, at corresponding disc space levels, were included for study. In each case note was made of the presence, absence and direction of disc displacement and also the presence and location of neural contact with the displaced disc. Results: In 33 of 38 (86.8%) patients in the spondylolisthesis group, the vertical disc displacement was upward. In the control group only 3 patients (7.8%) had upward vertical disc displacement. 19 patients (53%) from the spondylolisthesis group had exit foraminal nerve root contact, compared to 7 patients (18.4%) from the control group. 27 control patients (71%) had contact within the lateral recess, compared to only 6 patients (17%) with spondylolisthesis. Differences for upward displacement were significant (p < 0.05). Conclusion: Disc displacement in patients with spondylolisthesis is predominately in a cephalad and lateral direction. Although this disc displacement pattern can occur in patients without spondylolisthesis, its incidence is much greater in the subset of patients with concomitant spondylolisthesis. In the setting of acquired osseous narrowing of the exit foramen, this described pattern of disc displacement superiorly and laterally in spondylolisthesis increases the susceptibility of spondylolisthesis patients to radicular symptoms and accounts for the exiting nerve root being more commonly affected than the traversing nerve root.

  17. [Treatment of thoracic disc herniation. Case report].

    Science.gov (United States)

    Picado-Baca, Mauricio Leonardo; Mireles-Cano, José Nicolás; León-Meza, Víctor Manuel; García-González, Oscar Guillermo; Ramos-Trujillo, Alejandro

    2016-01-01

    Herniated thoracic intervertebral disc is a rare cause of spinal cord compression. Its frequency varies from 0.15% to 1.7% of all disc herniations, and produces symptoms in 0.5% to 0.8%. Case 1. A 50-year-old woman, with pain and burning sensation in left hemithorax of four months of onset. It was treated as a herpetic syndrome, with no improvement. She was seen after thirteen days of exacerbation of clinical symptoms. The physical examination showed asymmetric paraparesis, lower left pelvic limb 1/5, and right pelvic limb 3/5¸ sensory level T8, with left Babinski positive. A thoracic disc herniation in space T8-T9 was diagnosed. A 55-year-old patient with a history of presenting pain in lumbar area of 5 years onset. She also had radicular pain that radiated to the right pelvic limb, with intensity 10/10 on a Visual Analogue Scale. Her physical examination showed muscle strength 5/5, with normal sensitivity in all dermatomes and tendon reflexes, and a positive right Babinski. Thoracic disc herniation T7-T8 level was diagnosed. Due to anatomical conditions that define this type of hernia, the extracavitary posterolateral approach should be the recommended surgical procedure when the simultaneously performed anterior decompression and fixation with posterior instrumentation are the treatments proposed. Despite the different anatomical structures of this special area, it was possible to obtain satisfactory results for both clinical cases. Copyright © 2015 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

  18. Optic Disc Change during Childhood Myopic Shift: Comparison between Eyes with an Enlarged Cup-To-Disc Ratio and Childhood Glaucoma Compared to Normal Myopic Eyes.

    Directory of Open Access Journals (Sweden)

    Hae-Young Lopilly Park

    Full Text Available Progressive disc tilting and the development or enlargement of peripapillary atrophy (PPA are observed during a myopic shift in children. This could be related to the changes around the optic nerve head during eyeball elongation. If the biomechanical properties at or around the optic nerve head are changed after exposure to elevated intraocular pressure (IOP in glaucoma eyes, different response of the disc tilting and PPA changes could take place during eyeball elongation by myopic shift. On the basis of this background, the aim of this study was to compare the morphological changes in the optic disc induced by a myopic shift during childhood between normal control eyes, eyes from disc suspects with an enlarged cup-to-disc ratio (CDR, and eyes with childhood glaucoma.Total of 82 eyes from 82 subjects younger than 14 years of age were included in the study. Serial disc photographs were classified into one of two groups: eyes with an optic nerve head (ONH or peripapillary atrophy (PPA change or without an ONH/PPA change. Using ImageJ software, the outlines of the optic disc and PPA were plotted, and the vertical disc diameter (VDD, horizontal disc diameter (HDD, and maximum PPA width (PPW were measured. The changes in the ratios of these parameters and the relationships between the degree of myopic shift or the ONH/PPA change were analyzed.Twenty-five eyes with normal optic disc appearance, 36 eyes with enlarged cup-to-disc ratio, and 21 eyes of glaucoma patients were analyzed. The initial intraocular pressure (IOP at diagnosis was significantly different among the groups (P<0.001. The degree of myopic shift during follow-up period was not significantly different among the groups (P=0.612. However, the changes in the HDD/VDD and PPW/VDD ratios were significantly greater in the disc suspect group and significantly smaller in the glaucoma group. Among the 42 eyes with an ONH/PPA change, 16 (38.1% were from the normal control group, 24 (57.1% were

  19. Diverse electron-induced optical emissions from space observatory materials at low temperatures

    Science.gov (United States)

    Dennison, J. R.; Evans Jensen, Amberly; Wilson, Gregory; Dekany, Justin; Bowers, Charles W.; Meloy, Robert

    2013-09-01

    Electron irradiation experiments have investigated the diverse electron-induced optical and electrical signatures observed in ground-based tests of various space observatory materials at low temperature. Three types of light emission were observed: (i); long-duration cathodoluminescence which persisted as long as the electron beam was on (ii) short-duration (polyimides, epoxy resins, and silica glasses) and composite dielectric materials (disordered SiO2 thin films, carbon- and fiberglass-epoxy composites, and macroscopically-conductive carbon-loaded polyimides). We conclude that electron-induced optical emissions resulting from interactions between observatory materials and the space environment electron flux can, in specific circumstances, make significant contributions to the stray light background that could possibly adversely affect the performance of space-based observatories.

  20. Self-regulated gravitational accretion in protostellar discs

    CERN Document Server

    Vorobyov, E I

    2007-01-01

    We present a numerical model for the evolution of a protostellar disc that has formed self-consistently from the collapse of a molecular cloud core. The global evolution of the disc is followed for several million years after its formation. The capture of a wide range of spatial and temporal scales is made possible by use of the thin-disc approximation. We focus on the role of gravitational torques in transporting mass inward and angular momentum outward during different evolutionary phases of a protostellar disc with disc-to-star mass ratio of order 0.1. In the early phase, when the infall of matter from the surrounding envelope is substantial, mass is transported inward by the gravitational torques from spiral arms that are a manifestation of the envelope-induced gravitational instability in the disc. In the late phase, when the gas reservoir of the envelope is depleted, the distinct spiral structure is replaced by ongoing irregular nonaxisymmetric density perturbations. The amplitude of these density pertu...

  1. Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins

    Directory of Open Access Journals (Sweden)

    S Capossela

    2014-04-01

    Full Text Available Degeneration of intervertebral discs (IVDs is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose the avascular nucleus pulposus (NP to the systemic circulation and induce an autoimmune reaction. In this study, we confirmed our previous observation of antibodies in human degenerated and post-traumatic IVDs cultured in vitro. We hypothesised that the presence of antibodies was due to an autoimmune reaction against specific proteins of the disc. Furthermore we identified antigens which possibly trigger an autoimmune response in degenerative disc diseases. We demonstrated that degenerated and post-traumatic IVDs contain IgG antibodies against typical extracellular proteins of the disc, particularly proteins of the NP. We identified IgGs against collagen type II and aggrecan, confirming an autoimmune reaction against the normally immune privileged NP. We also found specific IgGs against collagens types I and V, but not against collagen type III. In conclusion, this study confirmed the association between disc degeneration and autoimmunity, and may open the avenue for future studies on developing prognostic, diagnostic and therapy-monitoring markers for degenerative disc diseases.

  2. Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins.

    Science.gov (United States)

    Capossela, S; Schläfli, P; Bertolo, A; Janner, T; Stadler, B M; Pötzel, T; Baur, M; Stoyanov, J V

    2014-04-04

    Degeneration of intervertebral discs (IVDs) is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose the avascular nucleus pulposus (NP) to the systemic circulation and induce an autoimmune reaction. In this study, we confirmed our previous observation of antibodies in human degenerated and post-traumatic IVDs cultured in vitro. We hypothesised that the presence of antibodies was due to an autoimmune reaction against specific proteins of the disc. Furthermore we identified antigens which possibly trigger an autoimmune response in degenerative disc diseases. We demonstrated that degenerated and post-traumatic IVDs contain IgG antibodies against typical extracellular proteins of the disc, particularly proteins of the NP. We identified IgGs against collagen type II and aggrecan, confirming an autoimmune reaction against the normally immune privileged NP. We also found specific IgGs against collagens types I and V, but not against collagen type III. In conclusion, this study confirmed the association between disc degeneration and autoimmunity, and may open the avenue for future studies on developing prognostic, diagnostic and therapy-monitoring markers for degenerative disc diseases.

  3. The gravitational microlens influence on X-ray spectral line generated by an AGN accretion disc

    Directory of Open Access Journals (Sweden)

    Popović L.Č.

    2001-01-01

    Full Text Available The influence of gravitational microlensing on the X-ray spectral line profiles originated from a relativistic accretion disc has been studied. Using a disc model, we show that microlensing can induce noticeable changes in the line shapes when the Einstein ring radius associated with the microlens is of a size comparable to that of the accretion disc. Taking into account the relatively small size of the X-ray accretion disc, we found that compact objects (of about a Solar mass which belong to the bulge of the host galaxy can produce significant changes in the X-ray line profile of AGN.

  4. Resonant thickening of self-gravitating discs: orbital diffusion in the tightly wound limit

    CERN Document Server

    Fouvry, Jean-Baptiste; Monk, Laura

    2016-01-01

    The secular thickening of a self-gravitating stellar galactic disc embedded in a fluctuating potential is investigated. The thick WKB limit for the diffusion coefficient of the corresponding dressed Fokker-Planck equation is found using the epicyclic approximation, while assuming that only radially tightly wound transient spirals are sustained by the disc. This yields a simple quadrature, providing a clear understanding of the positions of maximum vertical orbital diffusion within the disc. This thick limit also offers a consistent derivation of a thick disc Toomre parameter, which is shown to be exponentially boosted by the ratio of the vertical to radial scale heights. When applied to a tepid stable tapered disc perturbed by shot noise, this formalism predicts the formation of ridges of resonant orbits towards larger vertical actions, as found in simulations. Potential fluctuations within the disc statistically induce a vertical bending of a subset of resonant orbits, triggering the corresponding increase i...

  5. Eclipse mapping of accretion discs

    CERN Document Server

    Baptista, R

    2000-01-01

    The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations. I summarize the most important results obtained to date and discuss how they have helped to improve our understanding of accretion physics, from testing the theoretical radial brightness temperature distribution and measuring mass accretion rates to showing the evolution of the structure of a dwarf novae disc through its outburst cycle, from isolating the spectrum of a disc wind to revealing the geometry of disc spiral shocks. I end with an outline of the future prospects.

  6. Vortex migration in protoplanetary discs

    Directory of Open Access Journals (Sweden)

    Papaloizou John C. B.

    2013-04-01

    Full Text Available Vortices embedded in protoplanetary discs can act as obstacles to the unperturbed disc flow. The resulting velocity perturbations propagate away from the vortex in the form of density waves that transport angular momentum. Any asymmetry between the inner and the outer density wave means that the region around the vortex has to change its angular momentum. We find that this leads to orbital migration of the vortex. Asymmetric waves always arise except in the case of a disc with constant pressure, for isothermal as well as non-isothermal discs. Depending on the size and strength of the vortex, the resulting migration time scales can be as short as a few thousand orbits.

  7. Modelling Neutral Hydrogen Discs of Spiral Galaxies

    Institute of Scientific and Technical Information of China (English)

    林伟鹏; 洪碧海

    2002-01-01

    We present an analytical model of a neutral hydrogen disc in a spiral galaxy. The gas disc of the spiral galaxy isassumed to have an exponential surface density profile and to be ionized by the cosmic ultraviolet background.To compare with observations, we consider the disc position angle and inclination angle for a line of sight goingthrough the galaxy disc. The HI column densities depend on the strength of ionizing field and disc position andinclination. The model was applied to NGC 3198 and the results were compared with observational data. TheHI disc profile at large disc radii can be tested by further HI observations using radio telescopes with a largeraperture than the present facilities. This HI disc model can be used to predict quasar absorption line systems bygalaxy discs if quasar lines of sight go through the discs.

  8. Glucosamine Supplementation Demonstrates a Negative Effect On Intervertebral Disc Matrix in an Animal Model of Disc Degeneration

    Science.gov (United States)

    Jacobs, Lloydine; Vo, Nam; Coehlo, J. Paulo; Dong, Qing; Bechara, Bernard; Woods, Barrett; Hempen, Eric; Hartman, Robert; Preuss, Harry; Balk, Judith; Kang, James; Sowa, Gwendolyn

    2013-01-01

    Study Design Laboratory based controlled in vivo study Objective To determine the in vivo effects of oral glucosamine sulfate on intervertebral disc degeneration Summary of Background Data Although glucosamine has demonstrated beneficial effect in articular cartilage, clinical benefit is uncertain. A CDC report from 2009 reported that many patients are using glucosamine supplementation for low back pain (LBP), without significant evidence to support its use. Because disc degeneration is a major contributor of LBP, we explored the effects of glucosamine on disc matrix homeostasis in an animal model of disc degeneration. Methods Eighteen skeletally mature New Zealand White rabbits were divided into four groups: control, annular puncture, glucosamine, and annular puncture+glucosamine. Glucosamine treated rabbits received daily oral supplementation with 107mg/day (weight based equivalent to human 1500mg/day). Annular puncture surgery involved puncturing the annulus fibrosus (AF) of 3 lumbar discs with a 16G needle to induce degeneration. Serial MRIs were obtained at 0, 4, 8, 12, and 20 weeks. Discs were harvested at 20 weeks for determination of glycosaminoglycan(GAG) content, relative gene expression measured by RT-PCR, and histological analyses. Results The MRI index and NP area of injured discs of glucosamine treated animals with annular puncture was found to be lower than that of degenerated discs from rabbits not supplemented with glucosamine. Consistent with this, decreased glycosaminoglycan was demonstrated in glucosamine fed animals, as determined by both histological and GAG content. Gene expression was consistent with a detrimental effect on matrix. Conclusions These data demonstrate that the net effect on matrix in an animal model in vivo, as measured by gene expression, MRI, histology, and total proteoglycan is anti-anabolic. This raises concern over this commonly used supplement, and future research is needed to establish the clinical relevance of these

  9. Photon Bubbles in Accretion Discs

    OpenAIRE

    Gammie, Charles F.

    1998-01-01

    We show that radiation dominated accretion discs are likely to suffer from a ``photon bubble'' instability similar to that described by Arons in the context of accretion onto neutron star polar caps. The instability requires a magnetic field for its existence. In an asymptotic regime appropriate to accretion discs, we find that the overstable modes obey the remarkably simple dispersion relation \\omega^2 = -i g k F(B,k). Here g is the vertical gravitational acceleration, B the magnetic field, ...

  10. Self-gravitating accretion discs

    OpenAIRE

    Lodato, G.

    2008-01-01

    I review recent progresses in the dynamics and the evolution of self-gravitating accretion discs. Accretion discs are a fundamental component of several astrophysical systems on very diverse scales, and can be found around supermassive black holes in Active Galactic Nuclei (AGN), and also in our Galaxy around stellar mass compact objects and around young stars. Notwithstanding the specific differences arising from such diversity in physical extent, all these systems share a common feature whe...

  11. Disc piezoelectric ceramic transformers.

    Science.gov (United States)

    Erhart, Jirií; Půlpán, Petr; Doleček, Roman; Psota, Pavel; Lédl, Vít

    2013-08-01

    In this contribution, we present our study on disc-shaped and homogeneously poled piezoelectric ceramic transformers working in planar-extensional vibration modes. Transformers are designed with electrodes divided into wedge, axisymmetrical ring-dot, moonie, smile, or yin-yang segments. Transformation ratio, efficiency, and input and output impedances were measured for low-power signals. Transformer efficiency and transformation ratio were measured as a function of frequency and impedance load in the secondary circuit. Optimum impedance for the maximum efficiency has been found. Maximum efficiency and no-load transformation ratio can reach almost 100% and 52 for the fundamental resonance of ring-dot transformers and 98% and 67 for the second resonance of 2-segment wedge transformers. Maximum efficiency was reached at optimum impedance, which is in the range from 500 Ω to 10 kΩ, depending on the electrode pattern and size. Fundamental vibration mode and its overtones were further studied using frequency-modulated digital holographic interferometry and by the finite element method. Complementary information has been obtained by the infrared camera visualization of surface temperature profiles at higher driving power.

  12. Resonances in retrograde circumbinary discs

    CERN Document Server

    Nixon, Chris

    2015-01-01

    We analyse the interaction of an eccentric binary with a circular coplanar circumbinary disc that rotates in a retrograde sense with respect to the binary. In the circular binary case, no Lindblad resonances lie within the disc and no Lindblad resonant torques are produced, as was previously known. By analytic means, we show that when the binary orbit is eccentric, there exist components of the gravitational potential of the binary which rotate in a retrograde sense to the binary orbit and so rotate progradely with respect to this disc, allowing a resonant interaction to occur between the binary and the disc. The resulting resonant torques distinctly alter the disc response from the circular binary case. We describe results of three-dimensional hydrodynamic simulations to explore this effect and categorise the response of the disc in terms of modes whose strengths vary as a function of binary mass ratio and eccentricity. These mode strengths are weak compared to the largest mode strengths expected in the prog...

  13. Lumbar disc excision through fenestration

    Directory of Open Access Journals (Sweden)

    Sangwan S

    2006-01-01

    Full Text Available Background : Lumbar disc herniation often causes sciatica. Many different techniques have been advocated with the aim of least possible damage to other structures while dealing with prolapsed disc surgically in the properly selected and indicated cases. Methods : Twenty six patients with clinical symptoms and signs of prolapsed lumbar intervertebral disc having radiological correlation by MRI study were subjected to disc excision by interlaminar fenestration method. Results : The assessment at follow-up showed excellent results in 17 patients, good in 6 patients, fair in 2 patients and poor in 1 patient. The mean preoperative and postoperative Visual Analogue Scores were 9.34 ±0.84 and 2.19 ±0.84 on scale of 0-10 respectively. These were statistically significant (p value< 0.001, paired t test. No significant complications were recorded. Conclusion : Procedures of interlaminar fenestration and open disc excision under direct vision offers sufficient adequate exposure for lumbar disc excision with a smaller incision, lesser morbidity, shorter convalescence, early return to work and comparable overall results in the centers where recent laser and endoscopy facilities are not available.

  14. Counter-Rotating Accretion Discs

    CERN Document Server

    Dyda, Sergei; Ustyugova, Galina V; Romanova, Marina M; Koldoba, Alexander V

    2014-01-01

    Counter-rotating discs can arise from the accretion of a counter-rotating gas cloud onto the surface of an existing co-rotating disc or from the counter-rotating gas moving radially inward to the outer edge of an existing disc. At the interface, the two components mix to produce gas or plasma with zero net angular momentum which tends to free-fall towards the disc center. We discuss high-resolution axisymmetric hydrodynamic simulations of a viscous counter-rotating disc for cases where the two components are vertically separated and radially separated. The viscosity is described by an isotropic $\\alpha-$viscosity including all terms in the viscous stress tensor. For the vertically separated components a shear layer forms between them. The middle of this layer free-falls to the disk center. The accretion rates are increased by factors $\\sim 10^2-10^4$ over that of a conventional disc rotating in one direction with the same viscosity. The vertical width of the shear layer and the accretion rate are strongly dep...

  15. PATHOGENESIS OF OPTIC DISC EDEMA IN RAISED INTRACRANIAL PRESSURE

    Science.gov (United States)

    Hayreh, Sohan Singh

    2015-01-01

    Optic disc edema in raised intracranial pressure was first described in 1853. Ever since, there has been a plethora of controversial hypotheses to explain its pathogenesis. I have explored the subject comprehensively by doing basic, experimental and clinical studies. My objective was to investigate the fundamentals of the subject, to test the validity of the previous theories, and finally, based on all these studies, to find a logical explanation for the pathogenesis. My studies included the following issues pertinent to the pathogenesis of optic disc edema in raised intracranial pressure: the anatomy and blood supply of the optic nerve, the roles of the sheath of the optic nerve, of the centripetal flow of fluids along the optic nerve, of compression of the central retinal vein, and of acute intracranial hypertension and its associated effects. I found that, contrary to some previous claims, an acute rise of intracranial pressure was not quickly followed by production of optic disc edema. Then, in rhesus monkeys, I produced experimentally chronic intracranial hypertension by slowly increasing in size space-occupying lesions, in different parts of the brain. Those produced raised cerebrospinal fluid pressure (CSFP) and optic disc edema, identical to those seen in patients with elevated CSFP. Having achieved that, I investigated various aspects of optic disc edema by ophthalmoscopy, stereoscopic color fundus photography and fluorescein fundus angiography, and light microscopic, electron microscopic, horseradish peroxidase and axoplasmic transport studies, and evaluated the effect of opening the sheath of the optic nerve on the optic disc edema. This latter study showed that opening the sheath resulted in resolution of optic disc edema on the side of the sheath fenestration, in spite of high intracranial CSFP, proving that a rise of CSFP in the sheath was the essential pre-requisite for the development of optic disc edema. I also investigated optic disc edema with

  16. Self-Consistent, Axisymmetric Two-Integral Models of Elliptical Galaxies with Embedded Nuclear Discs

    OpenAIRE

    Bosch, van den, PPJ Paul; de, Zeeuw, W.

    1996-01-01

    Recently, observations with the Hubble Space Telescope have revealed small stellar discs embedded in the nuclei of a number of ellipticals and S0s. In this paper we construct two-integral axisymmetric models for such systems. We calculate the even part of the phase-space distribution function, and specify the odd part by means of a simple parameterization. We investigate the photometric as well as the kinematic signatures of nuclear discs, including their velocity profiles (VPs), and study th...

  17. The magnetic Rayleigh-Taylor instability in astrophysical discs

    Science.gov (United States)

    Contopoulos, I.; Kazanas, D.; Papadopoulos, D. B.

    2016-10-01

    This is our first study of the magnetic Rayleigh-Taylor instability at the inner edge of an astrophysical disc around a central back hole. We derive the equations governing small-amplitude oscillations in general relativistic ideal magnetodydrodynamics and obtain a criterion for the onset of the instability. We suggest that static disc configurations where magnetic field is held by the disc material are unstable around a Schwarzschild black hole. On the other hand, we find that such configurations are stabilized by the space-time rotation around a Kerr black hole. We obtain a crude estimate of the maximum amount of poloidal magnetic flux that can be accumulated around the centre, and suggest that it is proportional to the black hole spin. Finally, we discuss the astrophysical implications of our result for the theoretical and observational estimations of the black hole jet power.

  18. The truncation of stellar discs the magnetic hypothesis

    CERN Document Server

    Battaner, E

    2002-01-01

    We propose a hypothesis of the truncation of stellar discs based on the magnetic model of the rotation curve of spiral galaxies. Once the disc had formed and acquired its present structure, approximately, three balanced forces were acting on the initial gas: gravity and magnetic forces, inwards, and centrifugal force. When stars are formed from this gas, the magnetic force is suddenly suppressed. Gravitation alone cannot retain the newly-formed stars and at birth places beyond a certain galactocentric radius they escape to intergalactic space. This radius is the so-called ``truncation radius'', which is predicted to be at about 4-5 disc radial scale lengths, in promising agreement with observations.

  19. The Magnetic Rayleigh-Taylor Instability in Astrophysical Discs

    Science.gov (United States)

    Contopoulos, I.; Kazanas, D.; Papadopoulos, D. B.

    2016-01-01

    This is our first study of the magnetic Rayleigh-Taylor instability at the inner edge of an astrophysical disc around a central back hole. We derive the equations governing small-amplitude oscillations in general relativistic ideal magnetodydrodynamics and obtain a criterion for the onset of the instability. We suggest that static disc configurations where magnetic field is held by the disc material are unstable around a Schwarzschild black hole. On the other hand, we find that such configurations are stabilized by the space-time rotation around a Kerr black hole. We obtain a crude estimate of the maximum amount of poloidal magnetic flux that can be accumulated around the centre, and suggest that it is proportional to the black hole spin. Finally, we discuss the astrophysical implications of our result for the theoretical and observational estimations of the black hole jet power.

  20. The observed peripheral growth of disc galaxies from z ~ 1

    Science.gov (United States)

    Gadotti, Dimitri A.; Sachdeva, Sonali; Saha, Kanak; Singh, Harinder P.

    2017-03-01

    Using images from the Hubble Space Telescope and Sloan Digital Sky Survey, we have computed both parametric and non-parametric measures, and examined the evolution in size, concentration, stellar mass, effective stellar mass density and asymmetry for a sample of 600 disc galaxies from z ~ 1 till z ~ 0. We find that disc galaxies have gained more than 50 per cent of their present stellar mass over the last 8 Gyr. Also, the increase in disc size is found to be peripheral. While the average total (Petrosian) radius almost doubles from z ~ 1 to z ~ 0, the average effective (half-light) radius undergoes a marginal increase in comparison. This indicates that galaxies grow more substantially in their outskirts, and is consistent with the inside-out growth picture. The substantial increase in mass and size indicates that accretion of external material has been a dominant mode of galaxy growth, where the circumgalactic environment plays a significant role.

  1. Qp-spaces on bounded symmetric domains

    Directory of Open Access Journals (Sweden)

    Jonathan Arazy

    2008-01-01

    Full Text Available We generalize the theory of Qp spaces, introduced on the unit disc in 1995 by Aulaskari, Xiao and Zhao, to bounded symmetric domains in Cd, as well as to analogous Moebius-invariant function spaces and Bloch spaces defined using higher order derivatives; the latter generalization contains new results even in the original context of the unit disc.

  2. Disc instantons in linear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Govindarajan, Suresh E-mail: suresh@chaos.iitm.ernet.in; Jayaraman, T. E-mail: jayaram@imsc.ernet.in; Sarkar, Tapobrata E-mail: tapo@theory.tifr.res.in

    2002-12-16

    We construct a linear sigma model for open-strings ending on special Lagrangian cycles of a Calabi-Yau manifold. We illustrate the construction for the cases considered by Aganagic and Vafa (AV). This leads naturally to concrete models for the moduli space of open-string instantons. These instanton moduli spaces can be seen to be intimately related to certain auxiliary boundary toric varieties. By considering the relevant Gelfand-Kapranov-Zelevinsky (GKZ) differential equations of the boundary toric variety, we obtain the contributions to the world volume superpotential on the A-branes from open-string instantons. By using an ansatz due to Aganagic, Klemm and Vafa (AKV), we obtain the relevant change of variables from the linear sigma model to the non-linear sigma model variables--the open-string mirror map. Using this mirror map, we obtain results in agreement with those of AV and AKV for the counting of holomorphic disc instantons.

  3. Ranges of Cervical Intervertebral Disc Deformation during an In-Vivo Dynamic Flexion-Extension of the Neck.

    Science.gov (United States)

    Yu, Yan; Mao, Haiqing; Li, Jing-Sheng; Tsai, Tsung-Yuan; Cheng, Liming; Wood, Kirkham B; Li, Guoan; Cha, Thomas D

    2017-03-23

    While abnormal loading is widely believed to cause cervical spine disc diseases, in-vivo cervical disc deformation during dynamic neck motion has not been well delineated. This study investigated the range of cervical disc deformation during an in-vivo functional flexion-extension of the neck. Ten asymptomatic human subjects were tested using a combined dual fluoroscopic imaging system and MRI based 3D modeling technique. Overall disc deformation was determined using the changes of the space geometry between upper and lower endplates of each intervertebral segment (C3/4, C4/5, C5/6 and C6/7). Five points (anterior, center, posterior, left and right) of each disc were analyzed to examine the disc deformation distributions. The data indicated that between the functional maximum flexion and extension of the neck, the anterior points of the discs experienced large changes of distraction/compression deformation and shear deformation. The higher level discs experienced higher ranges of disc deformation. No significant difference was found in deformation ranges at posterior points of all discs. The data indicated that the range of disc deformation is disc level dependent and the anterior region experienced larger changes of deformation than the center and posterior regions, except for the C6/7 disc. The data obtained from this study could serve as baseline knowledge for the understanding of the cervical spine disc biomechanics and for investigation of the biomechanical etiology of disc diseases. These data could also provide insights for development of motion preservation surgeries for cervical spine.

  4. Orbit-Attitude Changes of Objects in Near Earth Space Induced by Natural Charging

    Science.gov (United States)

    2017-05-02

    COVERED (From - To) 21-05-2015 – 21-02-2017 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Orbit- Attitude Changes of Objects in Near Earth Space Induced...charging plasma conditions lead to significant secular perturbations in the investigated cases. 15. SUBJECT TERMS State-of-the Art; Attitude ...non-equilibrium scenario, charging takes place according to the differential equation, ∑ j I j = C dφdt . The time scale for charging of a spherical

  5. On Compensating Tune Spread Induced by Space Charge in Bunched Beams

    CERN Document Server

    Litvinenko, Vladimir N

    2014-01-01

    Space charge effects play significant role in modern-day accelerators. These effects frequently constrain attainable beam parameters in an accelerator - or - in an accelerator chain. They also could limit the luminosity of hadron colliders operating either at low energies or with a sub-TeV high brightness hadron beams. A number of schemes for compensating space charge effects in a coasting (e.g. continuous) hadron beam were proposed and some of them had been tested. But all of these methods do not address the issue of tune spread compensation of a bunched hadron beam, e.g. the tune shift dependence on the longitudinal position inside the bunch. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with miss-matched longitudinal velocity to compensate the space charge induced tune-shift and tune spread. We present a number of practical examples of such system.

  6. NIHAO VI. The hidden discs of simulated galaxies

    CERN Document Server

    Obreja, A; Dutton, A A; Macciò, A V; Wang, L; Kang, X

    2016-01-01

    Detailed studies of galaxy formation require clear definitions of the structural components of galaxies. Precisely defined components also enable better comparisons between observations and simulations. We use a subsample of eighteen cosmological zoom-in simulations from the NIHAO project to derive a robust method for defining stellar kinematic discs in galaxies. Our method uses Gaussian Mixture Models in a 3D space of dynamical variables. The NIHAO galaxies have the right stellar mass for their halo mass, and their angular momenta and S\\'ersic indices match observations. While the photometric disc-to-total ratios are close to 1 for all the simulated galaxies, the kinematic ratios are around ~0.5. Thus, exponential structure does not imply a cold kinematic disc. Above log(M*)~9.5, the decomposition leads to thin discs and spheroids that have clearly different properties, in terms of angular momentum, rotational support, ellipticity, [Fe/H] and [O/Fe]. At log(M*)<9.5, the decomposition selects discs and sph...

  7. OVERLOAD STUDY ON ADJACENT DISC AFTER ARTHRODESIS IN THORACOLUMBAR FRACTURES

    Directory of Open Access Journals (Sweden)

    GUSTAVO SERRA REINAS

    Full Text Available ABSTRACT Objective: To analyze the degeneration of the adjacent disc after arthrodesis due to thoracolumbar fractures. Methods: Eighty-three patients who underwent posterolateral arthrodesis in thoracolumbar levels had their x-rays analyzed for degeneration of adjacent discs to the arthrodesis. The disc spaces were classified by the UCLA scale. Results: Of the 83 patients evaluated, 66 were males (79% and 18 females (21%, with a mean age of 35.5 years. The mean follow-up period was 40 months. As the fractures 75% were between T12 and L2 (p<0.001, being of the A3 type in 65% of the cases (p<0.001. The most common mechanism of injury, accounting for 50% of the cases (p<0.001, was fall from height. Only 6% of the superior discs and 12% of the inferior ones showed some degree of degeneration. No patient underwent a new surgical approach. Conclusion: The incidence of degeneration on adjacent disc in patients after arthrodesis resulting from fractures ranged from 6% to 12% with an average follow-up of 40 months.

  8. On the relationship between circumstellar disc size and X-ray outbursts in Be/X-ray binaries

    Science.gov (United States)

    Monageng, I. M.; McBride, V. A.; Coe, M. J.; Steele, I. A.; Reig, P.

    2017-01-01

    We present long-term Hα monitoring results of five Be/X-ray binaries to study the Be disc size variations and their influence on type II (giant) X-ray outbursts. The work is done in the context of the viscous decretion disc model which predicts that Be discs in binary systems are truncated by resonant torques induced by the neutron star in its orbit. Our observations show that type II outbursts are not correlated (nor anticorrelated) with the disc size, as they are seen to occur both at relatively small and large Be disc radii. We discuss these observations in context of alternate interpretation of Be disc behaviour, such as precession, elongation and density effects, and with cognisance of the limitations of our disc size estimates.

  9. On the relationship between circumstellar disc size and X-ray outbursts in Be/X-ray binaries

    CERN Document Server

    Monageng, Itumeleng M; Coe, Malcolm J; Steele, Iain A; Reig, Pablo

    2016-01-01

    We present long term H$\\alpha$ monitoring results of five Be/X-ray binaries to study the Be disc size variations and their influence on Type II (giant) X-ray outbursts. The work is done in the context of the viscous decretion disc model which predicts that Be discs in binary systems are truncated by resonant torques induced by the neutron star in its orbit. Our observations show that type II outbursts are not correlated(nor anti-correlated) with the disc size, as they are seen to occur both at relatively small and large Be disc radii. We discuss these observations in context of alternate interpretation of Be disc behaviour, such as precession, elongation and density effects, and with cognisance of the limitations of our disc size estimates.

  10. Prosthetic Lumbar disc replacement for degenerative disc disease

    Directory of Open Access Journals (Sweden)

    Kulkarni Arvind

    2005-01-01

    Full Text Available Mechanical articulated device to replace intervertebral disc as a treatment for low back pain secondary to disc degeneration has emerged as a promising tool for selected patients. The potential advantages are prevention of adjacent segment degeneration, maintenance of mobility as well as avoidance of all the complications associated with fusion. The short-term results have been comparable to that of fusion, a few mid-term results have shown mixed outcome, but information on long-term results and performance are not available at present. The rationale for lumbar disc arthroplasty, indications, contraindications, the various artificial devices in the market and the concepts intrinsic to each of them, basic technique of insertion, complications are discussed and a brief summary of our experience with one of the devices is presented.

  11. Percutaneous cervical nucleoplasty in the treatment of cervical disc herniation.

    Science.gov (United States)

    Li, Jian; Yan, Deng-lu; Zhang, Zai-Heng

    2008-12-01

    Percutaneous disc decompression procedures have been performed in the past. Various percutaneous techniques such as percutaneous discectomy, laser discectomy, and nucleoplasty have been successful. Our prospective study was directly to evaluate the results of percutaneous cervical nucleoplasty (PCN) surgery for cervical disc herniation, and illustrate the effectiveness of PCN in symptomatic patients who had cervical herniated discs. From July of 2002 to June of 2005, 126 consecutive patients with contained cervical disc herniations have presented at the authors' clinic and treated by PCN. The patients' gender distribution for PCN was 65 male, 61 female. The age of patients ranged from 34 to 66 years (mean 51.9 +/- 10.2 years). The levels of involvement were 21 cases at C3-4, 30 cases at C4-5, 40 cases at C5-6, and 35 cases at C6-7. The clinical outcomes, pain reduction and the segment stability were all recorded during this study. A clinical outcome was quantified by the Macnab standard and using VAS. The angular displacement (AD) > or =11 degrees or horizontal displacement (HD) > or =3 mm was considered to be radiographically unstable. In the results of this study, puncture of the needle into the disc space was accurately performed under X-ray guidance in all cases. There was one case where the Perc-D Spine Wand had broken in the disc space during the procedure. The partial Perc-D Spine Wand, which had broken in the disc space could not be removed by the percutaneous cervical discectomy and thus remained there. There were no recurrent cases or complications in our series. Macnab standard results were excellent in 62 cases, good in 41 cases and fair in 23 cases. The rate of excellent and good was 83.73%. The VAS scores demonstrated statistically significant improvement in PCN at the 2-week, 1, 3, 6, and 12-month follow-up visits when compared to preoperational values (P PCN procedure. There was no significant difference in stability either preoperatively or

  12. Analyses of the temporomandibular disc.

    Science.gov (United States)

    Jirman, R; Fricová, M; Horák, Z; Krystůfek, J; Konvicková, S; Mazánek, J

    2007-01-01

    This project is the beginning of a large research work with a goal to develop a new total replacement of temporomandibular (TM) joint. First aim of this work was to determine the relative displacement of the TM disc and the mandible during mouth opening. The movement of the TM disc was studied using a magnetic resonance imaging. Sagittal static images in revolved sections of the TM joint were obtained in various positions of jaw opening from 0 to 50 mm. The results provided a description of the TM disc displacements as a function of jaw opening. The displacements of the mandible and TM disc were about 16 mm and 10 mm respectively at mouth opening of 50 mm, maximum rotation of the mandible was 34s. The results of these measurements can be used for clinical diagnostics and also they were used as inputs for the follows finite element analysis (FEA). Second aim of this work was to create stress and strain analysis of TM joint using non-linear FEA. Complex of TM joint consists of mandibular disc, half skull and half mandible during normal jaw opening. The results illustrate the stress distributions in the TMJ during a normal jaw opening.

  13. Reconstitution of degenerated ovine lumbar discs by STRO-3-positive allogeneic mesenchymal precursor cells combined with pentosan polysulfate.

    Science.gov (United States)

    Oehme, David; Ghosh, Peter; Goldschlager, Tony; Itescu, Silviu; Shimon, Susan; Wu, Jiehua; McDonald, Courtney; Troupis, John M; Rosenfeld, Jeffrey V; Jenkin, Graham

    2016-05-01

    OBJECTIVE Disc degeneration and associated low-back pain are major causes of suffering and disability. The authors examined the potential of mesenchymal precursor cells (MPCs), when formulated with pentosan polysulfate (PPS), to ameliorate disc degeneration in an ovine model. METHODS Twenty-four sheep had annular incisions made at L2-3, L3-4, and L4-5 to induce degeneration. Twelve weeks after injury, the nucleus pulposus of a degenerated disc in each animal was injected with ProFreeze and PPS formulated with either a low dose (0.1 million MPCs) or a high dose (0.5 million MPCs) of cells. The 2 adjacent injured discs in each spine were either injected with PPS and ProFreeze (PPS control) or not injected (nil-injected control). The adjacent noninjured L1-2 and L5-6 discs served as noninjured control discs. Disc height indices (DHIs) were obtained at baseline, before injection, and at planned death. After necropsy, 24 weeks after injection, the spines were subjected to MRI and morphological, histological, and biochemical analyses. RESULTS Twelve weeks after the annular injury, all the injured discs exhibited a significant reduction in mean DHI (low-dose group 17.19%; high-dose group 18.01% [p PPS formulation recovered disc height, and their mean DHI was significantly greater than the DHI of PPS- and nil-injected discs (p PPS-injected discs was lower than that for the nil- and PPS-injected discs, the differences were not significant. The disc morphology scores for the nil- and PPS-injected discs were significantly higher than the normal control disc scores (p PPS-injected disc scores were not significantly different from those of the normal controls. The mean glycosaminoglycan content of the nuclei pulposus of the low-dose MPC+PPS-injected discs was significantly higher than that of the PPS-injected controls (p PPS-injected discs were lower than those for the PPS- and Nil-injected discs. The corresponding high-dose MPC+PPS-injected discs failed to show significant

  14. Sparse aperture masking interferometry survey of transitional discs. Search for substellar-mass companions and asymmetries in their parent discs

    Science.gov (United States)

    Willson, M.; Kraus, S.; Kluska, J.; Monnier, J. D.; Ireland, M.; Aarnio, A.; Sitko, M. L.; Calvet, N.; Espaillat, C.; Wilner, D. J.

    2016-10-01

    Context. Transitional discs are a class of circumstellar discs around young stars with extensive clearing of dusty material within their inner regions on 10s of au scales. One of the primary candidates for this kind of clearing is the formation of planet(s) within the disc that then accrete or clear their immediate area as they migrate through the disc. Aims: The goal of this survey was to search for asymmetries in the brightness distribution around a selection of transitional disc targets. We then aimed to determine whether these asymmetries trace dynamically-induced structures in the disc or the gap-opening planets themselves. Methods: Our sample included eight transitional discs. Using the Keck/NIRC2 instrument we utilised the Sparse Aperture Masking (SAM) interferometry technique to search for asymmetries indicative of ongoing planet formation. We searched for close-in companions using both model fitting and interferometric image reconstruction techniques. Using simulated data, we derived diagnostics that helped us to distinguish between point sources and extended asymmetric disc emission. In addition, we investigated the degeneracy between the contrast and separation that appear for marginally resolved companions. Results: We found FP Tau to contain a previously unseen disc wall, and DM Tau, LkHα330, and TW Hya to contain an asymmetric signal indicative of point source-like emission. We placed upper limits on the contrast of a companion in RXJ 1842.9-3532 and V2246 Oph. We ruled the asymmetry signal in RXJ 1615.3-3255 and V2062 Oph to be false positives. In the cases where our data indicated a potential companion we computed estimates for the value of McṀc and found values in the range of . Conclusions: We found significant asymmetries in four targets. Of these, three were consistent with companions. We resolved a previously unseen gap in the disc of FP Tau extending inwards from approximately 10 au. Based on observations made with the Keck observatory

  15. Bath-induced correlations in an infinite-dimensional Hilbert space

    Science.gov (United States)

    Nizama, Marco; Cáceres, Manuel O.

    2017-09-01

    Quantum correlations between two free spinless dissipative distinguishable particles (interacting with a thermal bath) are studied analytically using the quantum master equation and tools of quantum information. Bath-induced coherence and correlations in an infinite-dimensional Hilbert space are shown. We show that for temperature T> 0 the time-evolution of the reduced density matrix cannot be written as the direct product of two independent particles. We have found a time-scale that characterizes the time when the bath-induced coherence is maximum before being wiped out by dissipation (purity, relative entropy, spatial dispersion, and mirror correlations are studied). The Wigner function associated to the Wannier lattice (where the dissipative quantum walks move) is studied as an indirect measure of the induced correlations among particles. We have supported the quantum character of the correlations by analyzing the geometric quantum discord.

  16. Infrared characterization of thermal gradients on disc brakes

    Science.gov (United States)

    Panier, Stephane; Dufrenoy, Philippe; Bremond, Pierre

    2003-04-01

    The heat generated in frictional organs like brakes and clutches induces thermal distortions which may lead to localized contact areas and hot spots developments. Hot spots are high thermal gradients on the rubbing surface. They count among the most dangerous phenomena in frictional organs leading to damage, early failure and unacceptable braking performances such as brake fade or undesirable low frequency vibrations called hot judder. In this paper, an experimental study of hot spots occurrence in railway disc brakes is reported on. The aim of this study was to better classify and to explain the thermal gradients appearance on the surface of the disc. Thermograph measurements with an infrared camera have been carried out on the rubbing surface of brake discs on a full-scale test bench. The infrared system was set to take temperature readings in snap shot mode precisely synchronized with the rotation of the disc. Very short integration time allows reducing drastically haziness of thermal images. Based on thermographs, a classification of hot-spots observed in disc brakes is proposed. A detailed investigation of the most damaging thermal gradients, called macroscopic hot spots (MHS) is given. From these experimental researches, a scenario of hot spots occurrence is suggested step by step. Thanks to infrared measurements at high frequency with high resolution, observations give new highlights on the conditions of hot spots appearance. Comparison of the experimental observations with the theoretical approaches is finally discussed.

  17. Black hole accretion disc impacts

    CERN Document Server

    Pihajoki, Pauli

    2015-01-01

    We present an analytic model for computing the luminosity and spectral evolution of flares caused by a supermassive black hole impacting the accretion disc of another supermassive black hole. Our model includes photon diffusion, emission from optically thin regions and relativistic corrections to the observed spectrum and time-scales. We test the observability of the impact scenario with a simulated population of quasars hosting supermassive black hole binaries. The results indicate that for a moderate binary mass ratio of 0.3, and impact distances of 100 primary Schwarzschild radii, the accretion disc impacts can be expected to equal or exceed the host quasar in brightness at observed wavelength {\\lambda} = 510 nm up to z = 0.6. We conclude that accretion disc impacts may function as an independent probe for supermassive black hole binaries. We release the code used for computing the model light curves to the community.

  18. Atomic gas in debris discs

    Science.gov (United States)

    Hales, Antonio S.; Barlow, M. J.; Crawford, I. A.; Casassus, S.

    2017-04-01

    We have conducted a search for optical circumstellar absorption lines in the spectra of 16 debris disc host stars. None of the stars in our sample showed signs of emission line activity in either Hα, Ca II or Na I, confirming their more evolved nature. Four stars were found to exhibit narrow absorption features near the cores of the photospheric Ca II and Na I D lines (when Na I D data were available). We analyse the characteristics of these spectral features to determine whether they are of circumstellar or interstellar origins. The strongest evidence for circumstellar gas is seen in the spectrum of HD 110058, which is known to host a debris disc observed close to edge-on. This is consistent with a recent ALMA detection of molecular gas in this debris disc, which shows many similarities to the β Pictoris system.

  19. Coevolution of binaries and circumbinary gaseous discs

    Science.gov (United States)

    Fleming, David P.; Quinn, Thomas R.

    2017-01-01

    The recent discoveries of circumbinary planets by Kepler raise questions for contemporary planet formation models. Understanding how these planets form requires characterizing their formation environment, the circumbinary protoplanetary disc and how the disc and binary interact and change as a result. The central binary excites resonances in the surrounding protoplanetary disc which drive evolution in both the binary orbital elements and in the disc. To probe how these interactions impact binary eccentricity and disc structure evolution, N-body smooth particle hydrodynamics simulations of gaseous protoplanetary discs surrounding binaries based on Kepler 38 were run for 104 binary periods for several initial binary eccentricities. We find that nearly circular binaries weakly couple to the disc via a parametric instability and excite disc eccentricity growth. Eccentric binaries strongly couple to the disc causing eccentricity growth for both the disc and binary. Discs around sufficiently eccentric binaries which strongly couple to the disc develop an m = 1 spiral wave launched from the 1:3 eccentric outer Lindblad resonance which corresponds to an alignment of gas particle longitude of periastrons. All systems display binary semimajor axis decay due to dissipation from the viscous disc.

  20. Characterising the Gravitational Instability in Cooling Accretion Discs

    CERN Document Server

    Cossins, Peter; Clarke, Cathie

    2008-01-01

    We perform numerical analyses of the structure induced by gravitational instabilities in cooling gaseous accretion discs. For low enough cooling rates a quasi-steady configuration is reached, with the instability saturating at a finite amplitude in a marginally stable disc. We find that the saturation amplitude scales with the inverse square root of the cooling parameter beta = t_cool / t_dyn, which indicates that the heating rate induced by the instability is proportional to the energy density of the induced density waves. We find that at saturation the energy dissipated per dynamical time by weak shocks due is of the order of 20 per cent of the wave energy. From Fourier analysis of the disc structure we find that while the azimuthal wavenumber is roughly constant with radius, the mean radial wavenumber increases with radius, with the dominant mode corresponding to the locally most unstable wavelength. We demonstrate that the density waves excited in relatively low mass discs are always close to co-rotation,...

  1. Disc volume reduction with percutaneous nucleoplasty in an animal model.

    Directory of Open Access Journals (Sweden)

    Richard Kasch

    Full Text Available STUDY DESIGN: We assessed volume following nucleoplasty disc decompression in lower lumbar spines from cadaveric pigs using 7.1Tesla magnetic resonance imaging (MRI. PURPOSE: To investigate coblation-induced volume reductions as a possible mechanism underlying nucleoplasty. METHODS: We assessed volume following nucleoplastic disc decompression in pig spines using 7.1-Tesla MRI. Volumetry was performed in lumbar discs of 21 postmortem pigs. A preoperative image data set was obtained, volume was determined, and either disc decompression or placebo therapy was performed in a randomized manner. Group 1 (nucleoplasty group was treated according to the usual nucleoplasty protocol with coblation current applied to 6 channels for 10 seconds each in an application field of 360°; in group 2 (placebo group the same procedure was performed but without coblation current. After the procedure, a second data set was generated and volumes calculated and matched with the preoperative measurements in a blinded manner. To analyze the effectiveness of nucleoplasty, volumes between treatment and placebo groups were compared. RESULTS: The average preoperative nucleus volume was 0.994 ml (SD: 0.298 ml. In the nucleoplasty group (n = 21 volume was reduced by an average of 0.087 ml (SD: 0.110 ml or 7.14%. In the placebo group (n = 21 volume was increased by an average of 0.075 ml (SD: 0.075 ml or 8.94%. The average nucleoplasty-induced volume reduction was 0.162 ml (SD: 0.124 ml or 16.08%. Volume reduction in lumbar discs was significant in favor of the nucleoplasty group (p<0.0001. CONCLUSIONS: Our study demonstrates that nucleoplasty has a volume-reducing effect on the lumbar nucleus pulposus in an animal model. Furthermore, we show the volume reduction to be a coblation effect of nucleoplasty in porcine discs.

  2. Dual-layered Blu-ray disc ROM fabricated by all-spin method

    Science.gov (United States)

    Hisada, Kazuya; Hayashi, Kazuhiro; Nishikiori, Keiji; Ohno, Eiji

    2004-09-01

    We developed fabrication process using "all spin method" for dual layered Blu-ray Disc ROM. All of the light transmitting layer consisting of a space layer, a cover layer and a hard coat are formed by spin-coating method. Regarding the cover layer, the cycle time is less than 15 seconds and the efficiency of usage of the UV curable resin is 59%. The fabricated disc has sufficient property of thickness variation of the light transmitting layer for all disc area. The disc also has good performances of tilt characteristics including tilt transition caused by environmental sudden change due to the moisture control layer although the substrate material is conventional poly-carbonate. We confirmed the feasibility of the dual layered BD-ROM by "all spin method" and it shows the possibility of low cost BD-ROM disc.

  3. Vertical kinematics of the thick disc at 4.5 < R < 9.5 kpc

    CERN Document Server

    Hattori, Kohei

    2015-01-01

    We explored a method to reconstruct the distribution function of the Galactic thick disc within the action space where nearby thick-disc stars are distributed. By applying this method to 127 chemically-selected thick-disc stars in the Solar neighbourhood, we found that the vertical velocity dispersion that corresponds to the reconstructed distribution function declines approximately as $\\exp (-R/R_s)$ at 4.5 kpc < R < 9.5 kpc, with $R_s$ = 8.3 $\\pm$ 1.1 (rand.) $\\pm$ 1.6 (sys.) kpc. Also, we found that the vertical velocity dispersion $\\sigma_z$ of our local thick-disc stars shows only weak dependency on radial and azimuthal velocities $(v_R, v_\\phi)$. We discuss possible implications of these results on the global structure of the Milky Way thick disc.

  4. Vertebral osteomyelitis without disc involvement

    Energy Technology Data Exchange (ETDEWEB)

    Kamani, I.; Syed, I.; Saifuddin, A. E-mail: asaifuddin@aol.com; Green, R.; MacSweeney, F

    2004-10-01

    Vertebral osteomyelitis is most commonly due to pyogenic or granulomatous infection and typically results in the combined involvement of the intervertebral disc and adjacent vertebral bodies. Non-infective causes include the related conditions of chronic recurrent multifocal osteomyelitis (CRMO) and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Occasionally, these conditions may present purely within the vertebral body, resulting in various combinations of vertebral marrow oedema and sclerosis, destructive lesions of the vertebral body and pathological vertebral collapse, thus mimicking neoplastic disease. This review illustrates the imaging features of vertebral osteomyelitis without disc involvement, with emphasis on magnetic resonance imaging (MRI) findings.

  5. Dead discs, unstable discs and the stars they surround

    Directory of Open Access Journals (Sweden)

    D’Angelo Caroline

    2014-01-01

    Full Text Available Strong stellar magnetic fields significantly alter the behaviour of surrounding accretion discs. Recent work has demonstrated that at low accretion rates a large amount of mass can remain confined in the disc, contrary to the standard assumption that the magnetic field will expel the disc in an outflow (the “propeller regime”. These “dead discs” often become unstable, causing cycles of accretion onto the central star. Here I present the main predictions of this model, and argue that it provides a good explanation for the peculiar behaviour seen in several accreting sources with strong magnetic fields. I will focus in particular on three accreting millisecond X-ray pulsars: SAX J1808.4-3658, NGC 6440 X-2 and IGR J00291+5934. These sources all show low-frequency quasi-periodic oscillations consistent with a variable accretion rate, as well as unusual outburst patterns that suggest gas is confined in the inner disc regions during quiescence.

  6. [Stimulation of degenerative changes in the intervertebral disc through axial compression. Radiologic, histologic and biomechanical research in an animal model].

    Science.gov (United States)

    Unglaub, F; Lorenz, H; Nerlich, A; Richter, W; Kroeber, M W

    2003-01-01

    Degeneration of the intervertebral disc is a common disease in the adults, especially at advanced age. A causal therapy is not known, but the progress in new therapeutic strategies, for example in tissue engineering, shows new possibilities. The goal of our study was to develop a new animal model that stimulates a load induced degeneration of the disc. We used the New Zealand rabbit, because morphology is similar to the human intervertebral disc. The degeneration was induced by axial compression of the disc L4 - L5 with an external fixateur. After different loading intervals, the animals were sacrified and the discs examined by radiology, histology, apoptosis and biomechanical testing. Radiography showed a significant decrease of the disc thickness in all loaded groups. Morphologically the intervertebral discs of loaded rabbits showed degenerative changes which were comparable to those in humans. A significantly increased number of dead cells in the annulus occurred after 14 and 28 days loading compared to the controls. The bending stress measured as the load to failure was not significantly different between the unloaded discs and the 28 days loaded discs. The results show that our animal modell can create degeneration. Four weeks compression leads to significant degeneration. Degeneration of the discs persisted in animals that were allowed a recovery time of 28 days after 28 days of loading.

  7. The position of the condyle and the disc in temporomandibular joint dysfunction. Comparison between tomography and magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Naoki; Kawaguchi, Shinichi; Kudo, Takaharu; Hosoki, Hidehiko; Uemura, Shusaburo [Tokushima Univ. (Japan). School of Dentistry

    1999-03-01

    To evaluate for the position of the condylar head in the glenoid fossa (condylar position), authors designed a new, simple method. Furthermore, the correlation between the condylar position and articular disc displacement was examined. A total of 160 TMJs of 80 TMD patients examined by tomography and MRI were included in this study. Three segments, the anterior (=a), posterior (=b) and superior (=c) joint spaces as shown by tomography were measured. To evaluate the condylar position, 3 acquired values were substituted for 2 numerical expressions. Each antero-posterior and supero-inferior condylar position was expressed in APR and SIR quantitatively. APR=(b-a)/(b+a) x 100 SIR=(((a+b)/2-c)/((a+b)/2+c)) x 100 Articular disc positions were evaluated in 3 positions by MRI. The 3 positions were as follows; superior disc position, slightly anterior disc position, completely anterior disc position. The differences among the condylar position of the TMJs of the 3 positions were statistically examined. A total of 157 TMJs were quantitatively evaluated in 2 directions. Three TMJs could not be evaluated with this evaluation method. Significant differences were found concerning the antero-posterior direction between the superior disc position and the slightly anterior disc position, as well as the superior disc position and the completely anterior disc position. Significant differences were detected in the supero-inferior direction between the superior disc position and the completely anterior disc position, as well as the slightly anterior disc position and the completely anterior disc position. This method was useful to evaluate the condylar position. A correlation between the condylar position and articular disc displacement was found. (K.H.)

  8. Análise radiológica da degeneração discal experimental em coelhos Radiological analysis of experimental disc degeneration in rabbits

    Directory of Open Access Journals (Sweden)

    Emiliano Vialle

    2009-01-01

    Full Text Available OBJETIVO: Validar a avaliação radiográfica da degeneração discal experimental em coelhos. MÉTODOS: Os discos intervertebrais lombares de coelhos New Zealand foram puncionados três vezes com uma agulha 18G com profundidade limitada de 5mm, através de abordagem lateral. Foram realizadas radiografias seriadas pré e pós-operatórias imediatas, e depois de quatro, oito e 12 semanas do procedimento, com posterior análise da altura discal, formação de osteófito, esclerose da placa vertebral e presença de degeneração discal. A análise estatística dos dados foi validada pelo coeficiente de concordância Kappa, com intervalo de confiança (IC de 95%. RESULTADOS: Observou-se diminuição significativa do espaço discal nas radiografias em AP após 12 semanas de pós-operatório, com Kappa = 0,489 para IC 95% (0,25-0,72 com p OBJECTIVE: To validate radiographic evaluation of a rabbit model for disc degeneration. METHODS: Lumbar intervertebral discs of New Zealand rabbits were stabbed three times with a 18G needle at a limited depth of 5mm, through lateral approach. Serial radiographic images were taken on the early pre-and postoperative periods, and after four, eight and 12 weeks of the procedure, with subsequent analysis of disc height, osteophyte formation, endplate sclerosis, and presence of disc degeneration. The statistical analysis of data was validated by the Kappa coefficient, with a confidence interval (CI of 95%. RESULTS: A significant reduction of disc space was found on AP X-ray images after 12 postoperative weeks, with Kappa = 0.489 for CI 95% (0.25-0.72 with p < 0.001. X-ray signs of disc degeneration also presented Kappa = 0.63 for CI 95% (0.39-0.86 with p < 0.001. The remaining assessed criteria showed positive results, but with a lower Kappa value. CONCLUSION: The disc degeneration model using rabbits as proposed in this study was shown to be feasible, with positive X-ray correlation between pre- and postoperative images

  9. Phase diagram of mixtures of hard colloidal spheres and discs: A free-volume scaled-particle approach

    OpenAIRE

    Lekkerkerker, H. N. W.; Oversteegen, S.M.

    2004-01-01

    Phase diagrams of mixtures of colloidal hard spheres with hard discs are calculated by means of the free-volume theory. The free-volume fraction available to the discs is determined from scaled-particle theory. The calculations show that depletion induced phase separation should occur at low disc concentrations in systems now experimentally available. The gas–liquid equilibrium of the spheres becomes stable at comparable size ratios as with bimodal mixtures of spheres or mixtures of rods and ...

  10. Stress response of Caenorhabditis elegans induced by space crowding in a micro-column array chip.

    Science.gov (United States)

    Wang, Xixian; Tang, Lichun; Xia, Yuyang; Hu, Liang; Feng, Xiaojun; Du, Wei; Liu, Bi-Feng

    2013-04-01

    Crowding stress has been reported to play an important role in affecting physiological behaviour. To study this process, a reliable analytical method under confined space is essential. In this work, we demonstrated a microfluidic approach for investigating physiological responses of C. elegans to confined spaces. The PDMS microfluidic chip consisting of arrays of micro-columns enabled us to mimic different crowding conditions by changing the intervals among micro-columns. C. elegans were transferred into this micro-column array and the subcellular distribution of DAF-16, which is a well-known transcription factor regulating different stress responses, was monitored for analysing the physiological responses to the confined spaces. We found that the worms exhibited a gradual increase in DAF-16 nuclear localization in the micro-column array with intervals from 200 μm to 40 μm. Moreover, the results showed that the absence of food and crowding stress could cooperate to promote increased DAF-16 nuclear localization. Finally, loss-of-function mutations in mec-4 and mec-10, which are amiloride-sensitive Na(+) channel genes expressed in all six gentle touch neurons, accelerated the velocity of DAF-16 nuclear localization, induced by confined space, revealing that mec-4/mec-10 were not required for this stress response. Thus, this device will provide a versatile, reliable and controllable platform for crowding stress studies.

  11. Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc.

    Science.gov (United States)

    Leonardi, Rosalia; Rusu, Mugurel Constantin; Loreto, Federico; Loreto, Carla; Musumeci, Giuseppe

    2012-01-01

    Lubricin, which is a boundary joint lubricant, was investigated immunohistochemically in the bilaminar zone (BZ) of the human temporomandibular joint (TMJ), without any degenerative changes. Immunohistochemistry for lubricin detection was carried out on 33 TMJ discs obtained from 17 cadavers. Sections were incubated with diluted rabbit polyclonal anti-lubricin antibody and scored according to the percentage of lubricin immunopositive cells. Three different TMJ disc tissue compartments were analyzed, namely: the upper lamina, the inferior lamina and the loose connective tissue in the space between the laminae. The Mann-Whitney U test was used to compare protein expression (lubricin) among disc specimens' regions. Staining was noted within the TMJ disc cell populations in every disc tissue sample, with almost every cell immunolabeled by the lubricin antibody. The number of disc cells immunolabeled was almost the same in the 3 bilaminar zone regions. Positive extracellular matrix staining was also seen. The results of the present study suggest that lubricin is expressed in the TMJ disc bilaminar zone. Lubricin may have a role in normal disc posterior attachment physiology through the prevention of cellular adhesion as well as providing lubrication during normal bilaminar zone function.

  12. The long-term evolution of photoevaporating transition discs with giant planets

    CERN Document Server

    Rosotti, Giovanni P; Owen, James E

    2015-01-01

    Photo-evaporation and planet formation have both been proposed as mechanisms responsible for the creation of a transition disc. We have studied their combined effect through a suite of 2d simulations of protoplanetary discs undergoing X-ray photoevaporation with an embedded giant planet. In a previous work we explored how the formation of a giant planet triggers the dispersal of the inner disc by photo-evaporation at earlier times than what would have happened otherwise. This is particularly relevant for the observed transition discs with large holes and high mass accretion rates that cannot be explained by photo-evaporation alone. In this work we significantly expand the parameter space investigated by previous simulations. In addition, the updated model includes thermal sweeping, needed for studying the complete dispersal of the disc. After the removal of the inner disc the disc is a non accreting transition disc, an object that is rarely seen in observations. We assess the relative length of this phase, to...

  13. Photoevaporating transitional discs and molecular cloud cores

    Science.gov (United States)

    Li, Min; Sui, Ning

    2017-04-01

    We investigate the evolution of photoevaporating protoplanetary discs including mass influx from molecular cloud cores. We examine the influence of cloud core properties on the formation and evolution of transitional discs. We use one-dimensional thin disc assumption and calculate the evolution of the protoplanetary disc. The effects of X-ray photoevaporation are also included. Our calculations suggest that most discs should experience the transitional disc phase within 10 Myr. The formation time of a gap and its initial location are functions of the properties of the cloud cores. In some circumstances, discs can open two gaps by photoevaporation alone. The two gaps form when the gas in the disc can expand to large radius and if the mass at large radius is sufficiently small. The surface density profile of the disc determines whether the two gaps can form. Since the structure of a disc is determined by the properties of a molecular cloud core, the core properties determine the formation of two gaps in the disc. We further find that even when the photoevaporation rate is reduced to 10 per cent of the standard value, two gaps can still form in the disc. The only difference is that the formation time is delayed.

  14. Radiation of accretion discs: the eclipses

    Energy Technology Data Exchange (ETDEWEB)

    Schwarzenberg-Czerny, A.

    1984-05-01

    Light curves have been calculated for eclipses of the accretion disc in a cataclysmic binary. The Roche geometry of the cool component was taken into account and the stellar atmospheres were interpolated to provide the local spectrum of the radiation from the disc. The dependence of the light curve on the parameters of the disc is discussed.

  15. Measurements of the Radiation Induced Conductivity of Insulating Polymeric Materials for the James Webb Space Telescope

    Science.gov (United States)

    Corbridge, J.; Dennison, J. R.; Hodges, J.; Hoffmann, R. C.; Abbott, J.; Hunt, A.; Spaulding, R.

    2006-10-01

    We report on initial measurements of Radiation Induced Conductivity (RIC) for twelve thin film polymer materials that are used in the cabling of the James Webb Space Telescope. Results will be used to model possible detrimental arching due to space craft charging effects. RIC occurs when incident ionizing radiation deposits energy in a material and excites electrons into the conduction band of insulators. RIC is determined using a constant voltage test method as the difference in the equilibrium sample conductivity under no incident radiation and sample conductivity under an incident flux. An accelerator beam at the Idaho Accelerator Center provides the 2-5 MeV incident flux over a range of 10^2 to 10^+1 rad/sec. Measurements are made for a range of applied voltages and radiation dose rates.

  16. The debris disc of solar analogue τ Ceti: Herschel observations and dynamical simulations of the proposed multiplanet system

    NARCIS (Netherlands)

    Lawler, S.M.; Di Francesco, J.; Kennedy, G.M.; Sibthorpe, B.; Booth, M.; Vandenbussche, B.; Matthews, B.C.; Holland, W.S.; Greaves, J.; Wilner, D.J.; Tuomi, M.; Blommaert, J.A.D.L.; de Vries, B.L.; Dominik, C.; Fridlund, M.; Gear, W.; Heras, A.M.; Ivison, R.; Olofsson, G.

    2014-01-01

    τ Ceti is a nearby, mature G-type star very similar to our Sun, with a massive Kuiper Belt analogue and possible multiplanet system that has been compared to our Solar system. We present Herschel Space Observatory images of the debris disc, finding the disc is resolved at 70 μm and 160 μm, and margi

  17. Intervertebral disc degeneration in dogs

    NARCIS (Netherlands)

    Bergknut, Niklas

    2011-01-01

    Back pain is common in both dogs and humans, and is often associated with intervertebral disc (IVD) degeneration. The IVDs are essential structures of the spine and degeneration can ultimately result in diseases such as IVD herniation or spinal instability. In order to design new treatments halting

  18. Electromagnetic Levitation of a Disc

    Science.gov (United States)

    Valle, R.; Neves, F.; de Andrade, R., Jr.; Stephan, R. M.

    2012-01-01

    This paper presents a teaching experiment that explores the levitation of a disc of ferromagnetic material in the presence of the magnetic field produced by a single electromagnet. In comparison to the classical experiment of the levitation of a sphere, the main advantage of the proposed laboratory bench is that the uniform magnetic field…

  19. Optical Disc Applications in Libraries.

    Science.gov (United States)

    Andre, Pamela Q. J.

    1989-01-01

    Discusses a variety of library applications of optical disc storage technology, including CD-ROM, digital videodisc, and WORM. Research and development projects at the Library of Congress, National Library of Medicine, and National Agricultural Library are described, products offered by library networks are reviewed, and activities in academic and…

  20. Electromagnetic Levitation of a Disc

    Science.gov (United States)

    Valle, R.; Neves, F.; de Andrade, R., Jr.; Stephan, R. M.

    2012-01-01

    This paper presents a teaching experiment that explores the levitation of a disc of ferromagnetic material in the presence of the magnetic field produced by a single electromagnet. In comparison to the classical experiment of the levitation of a sphere, the main advantage of the proposed laboratory bench is that the uniform magnetic field…

  1. Constraints on Slim Accretion Discs

    Institute of Scientific and Technical Information of China (English)

    CAI Zhen-Yi; GU Wei-Min; LU Ju-Fu

    2008-01-01

    @@ We show that when the gravitational force in the vertical direction is correctly calculated, the well-known Sshaped sequence of thermal equilibrium solutions can be constructed only for small radii of black hole accretion flows, such that slim accretion discs can possibly exist only in the inner regions of these flows.

  2. Magnetorotational instability in protoplanetary discs

    CERN Document Server

    Salmeron, Roberto Aureliano; Salmeron, Raquel; Wardle, Mark

    2004-01-01

    We investigate the linear growth and vertical structure of the magnetorotational instability (MRI) in weakly ionised, stratified accretion discs. The magnetic field is initially vertical and dust grains are assumed to have settled towards the midplane, so charges are carried by electrons and ions only. Solutions are obtained at representative radial locations from the central protostar for different choices of the initial magnetic field strength, sources of ionisation, and disc surface density. The MRI is active over a wide range of magnetic field strengths and fluid conditions in low conductivity discs. For the minimum-mass solar nebula model, incorporating cosmic ray ionisation, perturbations grow at 1 AU for B < 8 G. For a significant subset of these strengths (0.2 - 5 G), the growth rate is of order the ideal MHD rate (0.75 Omega). Similarly, when cosmic rays are assumed to be excluded from the disc by the winds emitted by the magnetically active protostar, unstable modes grow at this radius for B less...

  3. Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model.

    Science.gov (United States)

    Martin, John T; Milby, Andrew H; Chiaro, Joseph A; Kim, Dong Hwa; Hebela, Nader M; Smith, Lachlan J; Elliott, Dawn M; Mauck, Robert L

    2014-06-01

    Intervertebral disc degeneration has been implicated in the etiology of low back pain; however, the current surgical strategies for treating symptomatic disc disease are limited. A variety of materials have been developed to replace disc components, including the nucleus pulposus (NP), the annulus fibrosus (AF) and their combination into disc-like engineered constructs. We have previously shown that layers of electrospun poly(ε-caprolactone) scaffold, mimicking the hierarchical organization of the native AF, can achieve functional parity with native tissue. Likewise, we have combined these structures with cell-seeded hydrogels (as an NP replacement) to form disc-like angle-ply structures (DAPS). The objective of this study was to develop a model for the evaluation of DAPS in vivo. Through a series of studies, we developed a surgical approach to replace the rat caudal disc with an acellular DAPS and then stabilized the motion segment via external fixation. We then optimized cell infiltration into DAPS by including sacrificial poly(ethylene oxide) layers interspersed throughout the angle-ply structure. Our findings illustrate that DAPS are stable in the caudal spine, are infiltrated by cells from the peri-implant space and that infiltration is expedited by providing additional routes for cell migration. These findings establish a new in vivo platform in which to evaluate and optimize the design of functional disc replacements.

  4. Quantum-induced interactions in the moduli space of degenerate BPS domain walls

    Energy Technology Data Exchange (ETDEWEB)

    Alonso-Izquierdo, A. [Departamento de Matematica Aplicada and IUFFyM, Universidad de Salamanca,c/ del Parque 2, 37008-Salamanca (Spain); Guilarte, J. Mateos [Departamento de Fisica Fundamental and IUFFyM, Universidad de Salamanca,Plaza de la Merced s/n, 37008-Salamanca (Spain)

    2014-01-23

    In this paper quantum effects are investigated in a very special two-scalar field model having a moduli space of BPS topological defects. In a (1+1)-dimensional space-time the defects are classically degenerate in mass kinks, but in (3+1) dimensions the kinks become BPS domain walls, all of them sharing the same surface tension at the classical level. The heat kernel/zeta function regularization method will be used to control the divergences induced by the quantum kink and domain wall fluctuations. A generalization of the Gilkey-DeWitt-Avramidi heat kernel expansion will be developed in order to accommodate the infrared divergences due to zero modes in the spectra of the second-order kink and domain wall fluctuation operators, which are respectively N=2×N=2 matrix ordinary or partial differential operators. Use of these tools in the spectral zeta function associated with the Hessian operators paves the way to obtain general formulas for the one-loop kink mass and domain wall tension shifts in any (1+1)- or (3+1)-dimensional N-component scalar field theory model. Application of these formulae to the BPS kinks or domain walls of the N=2 model mentioned above reveals the breaking of the classical mass or surface tension degeneracy at the quantum level. Because the main parameter distinguishing each member in the BPS kink or domain wall moduli space is essentially the distance between the centers of two basic kinks or walls, the breaking of the degeneracy amounts to the surge in quantum-induced forces between the two constituent topological defects. The differences in surface tension induced by one-loop fluctuations of BPS walls give rise mainly to attractive forces between the constituent walls except if the two basic walls are very far apart. Repulsive forces between two close walls only arise if the coupling approaches the critical value from below.

  5. Use of microgravity sensors for quantification of space shuttle orbiter vernier reaction control system induced environments

    Science.gov (United States)

    Friend, Robert B.

    1998-01-01

    In the modeling of spacecraft dynamics it is important to accurately characterize the environment in which the vehicle operates, including the environments induced by the vehicle itself. On the Space Shuttle these induced environmental factors include reaction control system plume. Knowledge of these environments is necessary for performance of control systems and loads analyses, estimation of disturbances due to thruster firings, and accurate state vector propagation. During the STS-71 mission, while the Orbiter was performing attitude control for the mated Orbiter/Mir stack, it was noted that the autopilot was limit cycling at a rate higher than expected from pre-flight simulations. Investigations during the mission resulted in the conjecture that an unmodelled plume impingement force was acting upon the orbiter elevons. The in-flight investigations were not successful in determining the actual magnitude of the impingement, resulting in several sequential post-flight investigations. Efforts performed to better quantify the vernier reaction control system induced plume impingement environment of the Space Shuttle orbiter are described in this paper, and background detailing circumstances which required the more detailed knowledge of the RCS self impingement forces, as well as a description of the resulting investigations and their results is presented. The investigations described in this paper applied microgravity acceleration data from two shuttle borne microgravity experiments, SAMS and OARE, to the solution of this particular problem. This solution, now used by shuttle analysts and mission planners, results in more accurate propellant consumption and attitude limit cycle estimates in preflight analyses, which are critical for pending International Space Station missions.

  6. Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change.

    Science.gov (United States)

    Turker, Mitchell S; Grygoryev, Dmytro; Lasarev, Michael; Ohlrich, Anna; Rwatambuga, Furaha A; Johnson, Sorrel; Dan, Cristian; Eckelmann, Bradley; Hryciw, Gwen; Mao, Jian-Hua; Snijders, Antoine M; Gauny, Stacey; Kronenberg, Amy

    2017-01-01

    Exposure to a small number of high-energy heavy charged particles (HZE ions), as found in the deep space environment, could significantly affect astronaut health following prolonged periods of space travel if these ions induce mutations and related cancers. In this study, we used an in vivo mutagenesis assay to define the mutagenic effects of accelerated 56Fe ions (1 GeV/amu, 151 keV/μm) in the mouse kidney epithelium exposed to doses ranging from 0.25 to 2.0 Gy. These doses represent fluences ranging from 1 to 8 particle traversals per cell nucleus. The Aprt locus, located on chromosome 8, was used to select induced and spontaneous mutants. To fully define the mutagenic effects, we used multiple endpoints including mutant frequencies, mutation spectrum for chromosome 8, translocations involving chromosome 8, and mutations affecting non-selected chromosomes. The results demonstrate mutagenic effects that often affect multiple chromosomes for all Fe ion doses tested. For comparison with the most abundant sparsely ionizing particle found in space, we also examined the mutagenic effects of high-energy protons (1 GeV, 0.24 keV/μm) at 0.5 and 1.0 Gy. Similar doses of protons were not as mutagenic as Fe ions for many assays, though genomic effects were detected in Aprt mutants at these doses. Considered as a whole, the data demonstrate that Fe ions are highly mutagenic at the low doses and fluences of relevance to human spaceflight, and that cells with considerable genomic mutations are readily induced by these exposures and persist in the kidney epithelium. The level of genomic change produced by low fluence exposure to heavy ions is reminiscent of the extensive rearrangements seen in tumor genomes suggesting a potential initiation step in radiation carcinogenesis.

  7. Spaces

    Directory of Open Access Journals (Sweden)

    Maziar Nekovee

    2010-01-01

    Full Text Available Cognitive radio is being intensively researched as the enabling technology for license-exempt access to the so-called TV White Spaces (TVWS, large portions of spectrum in the UHF/VHF bands which become available on a geographical basis after digital switchover. Both in the US, and more recently, in the UK the regulators have given conditional endorsement to this new mode of access. This paper reviews the state-of-the-art in technology, regulation, and standardisation of cognitive access to TVWS. It examines the spectrum opportunity and commercial use cases associated with this form of secondary access.

  8. Towards long term cultivation of Drosophila wing imaginal discs in vitro.

    Directory of Open Access Journals (Sweden)

    Björn Handke

    Full Text Available The wing imaginal disc of Drosophila melanogaster is a prominent experimental system for research on control of cell growth, proliferation and death, as well as on pattern formation and morphogenesis during organogenesis. The precise genetic methodology applicable in this system has facilitated conceptual advances of fundamental importance for developmental biology. Experimental accessibility and versatility would gain further if long term development of wing imaginal discs could be studied also in vitro. For example, culture systems would allow live imaging with maximal temporal and spatial resolution. However, as clearly demonstrated here, standard culture methods result in a rapid cell proliferation arrest within hours of cultivation of dissected wing imaginal discs. Analysis with established markers for cells in S- and M phase, as well as with RGB cell cycle tracker, a novel reporter transgene, revealed that in vitro cultivation interferes with cell cycle progression throughout interphase and not just exclusively during G1. Moreover, quantification of EGFP expression from an inducible transgene revealed rapid adverse effects of disc culture on basic cellular functions beyond cell cycle progression. Disc transplantation experiments confirmed that these detrimental consequences do not reflect fatal damage of imaginal discs during isolation, arguing clearly for a medium insufficiency. Alternative culture media were evaluated, including hemolymph, which surrounds imaginal discs during growth in situ. But isolated larval hemolymph was found to be even less adequate than current culture media, presumably as a result of conversion processes during hemolymph isolation or disc culture. The significance of prominent growth-regulating pathways during disc culture was analyzed, as well as effects of insulin and disc co-culture with larval tissues as potential sources of endocrine factors. Based on our analyses, we developed a culture protocol that

  9. Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration--an in vivo animal study.

    Science.gov (United States)

    Guehring, Thorsten; Omlor, Georg W; Lorenz, Helga; Bertram, Helge; Steck, Eric; Richter, Wiltrud; Carstens, Claus; Kroeber, Markus

    2005-11-15

    An external compression model was used to evaluate gene and protein expression in intervertebral discs with moderate disc degeneration. To determine messenger ribonucleic acid and protein expression levels of relevant disc components. An animal model of mechanically induced disc degeneration was developed and characterized histologically. However, little is known at the molecular level in moderate disc degeneration. There were 8 New Zealand white rabbits subjected to monosegmental posterior compression to induce moderate disc degeneration. Twelve animals served as controls or sham controls. Discs were analyzed using immunohistochemistry for collagen type 1 (COL1), COL2, aggrecan, and bone morphogenetic protein-2/4 (BMP-2/4). For gene analysis, conventional and quantitative polymerase chain reactions were used for COL1A2, COL2A1, aggrecan, BMP-2, biglycan, decorin, osteonectin, fibromodulin, fibronectin, matrix metalloproteinase-13 (MMP-13), and tissue inhibitor of MMP-1. Gene expression for nontreated, sham-treated, and compressed discs was quantified in relation to the housekeeping gene glyceraldehyde-3-phosphate dehydrogenase. Immunohistochemistry of compressed discs showed a loss of anular architecture, and a significant reduction of BMP-2/4 and COL2 positive cells. Gene expression analysis showed a significant up-regulation of COL1A2, osteonectin, decorin, fibronectin, tissue inhibitor of MMP-1, BMP-2, and MMP-13 in compressed discs. Experimental moderate disc degeneration is characterized by a loss of BMP-2/4 and COL2 positive cells, although gene expression of disc constituents, catabolic enzymes, and growth factors is stimulated to reestablish disc integrity.

  10. State-space approach to vibration of gold nano-beam induced by ramp type heating

    Institute of Scientific and Technical Information of China (English)

    Hamdy M Youssef; Khaled A Elsibai

    2010-01-01

    In the nanoscale beam, two effects become domineering. One is the non-Fourier effect in heat conduction and the other is the coupling effect between temperature and strain rate. In the present study, a generalized solution for the generalized thermoelastic vibration of gold nano-beam resonator induced by ramp type heating is developed. The solution takes into account the above two effects. State-space and Laplace transform methods are used to determine the lateral vibration, the temperature, the displacement, the stress and the strain energy of the beam. The effects of the relaxation time and the ramping time parameters have been studied.

  11. LAMB SHIFT IN HYDROGEN-LIKE ATOM INDUCED FROM NON-COMMUTATIVE QUANTUM SPACE-TIME

    Directory of Open Access Journals (Sweden)

    S Zaim

    2015-06-01

    Full Text Available In this work we present an important contribution to the non-commutative approach to the hydrogen atom to deal with lamb shift corrections. This can be done by studying the Klein-Gordon equation in a non-commutative space-time as applied to the Hydrogen atom to extract the energy levels, by considering the second-order corrections in the non commutativity parameter and by comparing with the result of the current experimental results on the Lamb shift of the 2P level to extract a bound on the parameter of non-commutativity. Phenomenologically we show that the non-commutativity effects induce lamb shift corrections.

  12. Medium-term outcomes of artificial disc replacement for severe cervical disc narrowing

    Directory of Open Access Journals (Sweden)

    Chao-Hung Yeh

    2014-01-01

    Conclusions: Acceptable clinical outcome for treatment of severe cervical disc narrowing with cervical disc replacement technique has been performed in current study. Most patients maintained good postoperative mobility and no significant adjacent level degeneration were found. Cervical disc replacement may be applicable in treatment of severe cervical disc narrowing; however, longer follow-ups are required for ensuring the long-term efficacy of cervical disc replacement.

  13. Intervertebral disc calcifications in children.

    Science.gov (United States)

    Beluffi, G; Fiori, P; Sileo, C

    2009-03-01

    This study was done to assess the presence of both asymptomatic and symptomatic intervertebral disc calcifications in a large paediatric population. We retrospectively reviewed the radiographs taken during the past 26 years in children (age 0-18 years) undergoing imaging of the spine or of other body segments in which the spine was adequately depicted, to determine possible intervertebral disc calcifications. The following clinical evaluation was extrapolated from the patients' charts: presence of spinal symptoms, history of trauma, suspected or clinically evident scoliosis, suspected or clinically evident syndromes, bone dysplasias, and pre- or postoperative chest or abdominal X-rays. We detected intervertebral disc calcifications in six patients only. Five calcifications were asymptomatic (one newborn baby with Patau syndrome; three patients studied to rule out scoliosis, hypochondroplasia and syndromic traits; one for dyspnoea due to sunflower seeds inhalation). Only one was symptomatic, with acute neck pain. Calcifications varied in number from one in one patient to two to five in the others. Apart from the calcification in the patient with cervical pain, all calcifications were asymptomatic and constituted an incidental finding (particularly those detected at the thoracic level in the patient studied for sunflower-seed inhalation). Calcification shapes were either linear or round. Our series confirms that intervertebral disc calcifications are a rare finding in childhood and should not be a source of concern: symptomatic calcifications tend to regress spontaneously within a short time with or without therapy and immobilisation, whereas asymptomatic calcifications may last for years but disappear before the age of 20 years. Only very few cases, such as those of medullary compression or severe dysphagia due to anterior herniation of cervical discs, may require surgical procedures.

  14. Disc degeneration: current surgical options

    Directory of Open Access Journals (Sweden)

    C Schizas

    2010-10-01

    Full Text Available Chronic low back pain attributed to lumbar disc degeneration poses a serious challenge to physicians. Surgery may be indicated in selected cases following failure of appropriate conservative treatment. For decades, the only surgical option has been spinal fusion, but its results have been inconsistent. Some prospective trials show superiority over usual conservative measures while others fail to demonstrate its advantages. In an effort to improve results of fusion and to decrease the incidence of adjacent segment degeneration, total disc replacement techniques have been introduced and studied extensively. Short-term results have shown superiority over some fusion techniques. Mid-term results however tend to show that this approach yields results equivalent to those of spinal fusion. Nucleus replacement has gained some popularity initially, but evidence on its efficacy is scarce. Dynamic stabilisation, a technique involving less rigid implants than in spinal fusion and performed without the need for bone grafting, represents another surgical option. Evidence again is lacking on its superiority over other surgical strategies and conservative measures. Insertion of interspinous devices posteriorly, aiming at redistributing loads and relieving pain, has been used as an adjunct to disc removal surgery for disc herniation. To date however, there is no clear evidence on their efficacy. Minimally invasive intradiscal thermocoagulation techniques have also been tried, but evidence of their effectiveness is questioned. Surgery using novel biological solutions may be the future of discogenic pain treatment. Collaboration between clinicians and basic scientists in this multidisciplinary field will undoubtedly shape the future of treating symptomatic disc degeneration.

  15. Investigation on the radiation induced conductivity of space-applied polyimide under cyclic electron irradiation

    Science.gov (United States)

    Yue, Long; Wu, Yiyong; Sun, Chengyue; Xiao, Jingdong; Shi, Yaping; Ma, Guoliang; He, Shiyu

    2012-11-01

    Radiation induced conductivity (RIC) is an important property of dielectric materials to evaluate the charge/discharge effect in orbit-service spacecraft. RIC of space-applied polyimide film was in situ measured and studied under continuous and cyclic electron irradiation in this paper. The results indicate that, for cyclic electron irradiation, there is a similar increasing-mode of RIC to those for continuous irradiation with the electron irradiation time. However, under the cyclic electron irradiation, the RIC of polyimide shows an obvious irradiation-history characteristic, namely preliminary irradiation dose effect (PIDE). In this case, the steady RIC value presents an "overshoot" behavior in the first few irradiation cycles and then decrease to a stable one as that under continuous irradiation. Prolonging the initial irradiation duration may avoid occurrence of overshoot phenomenon. The behaviors of irradiation-induced free radicals in polyimide could be applied to explain the RIC evolution processes.

  16. GRINDING OF DOUBLE DISC GRINDING MACHINE

    Institute of Scientific and Technical Information of China (English)

    Hu Huiqing

    2005-01-01

    The grinding of two parallel sides of a component is accomplished with the accuracy and higher productivity by passing a blank through the truncated cone shape grinders, which are turned angles. The machine is designated by the name of double disc grinding machine (DDGM). Usually, it is used in the mass production. The relationship between these angles, the accuracy, productivity,allowance and parameters of the machine and technology is explained in detail by math, such as vector analysis, transformation of 3D space coordinates, etc. Therefore, in the aspects of qualitative and quantitative analyses, the grinding potential of DDGM is enormous increased and superior to conventional methods. Furthermore, the theoretical foundation of DDGM grinding design and technology is provided to improve, to expand and to create for future. The established machine design and practical experience of grinding technology will get great benefit by them.

  17. Self-consistent, axisymmetric two-integral models of elliptical galaxies with embedded nuclear discs

    CERN Document Server

    Van den Bosch, F C; van den Bosch, Frank C; de Zeeuw, P Tim

    1996-01-01

    Recently, observations with the Hubble Space Telescope have revealed small stellar discs embedded in the nuclei of a number of ellipticals and S0s. In this paper we construct two-integral axisymmetric models for such systems. We calculate the even part of the phase-space distribution function, and specify the odd part by means of a simple parameterization. We investigate the photometric as well as the kinematic signatures of nuclear discs, including their velocity profiles (VPs), and study the influence of seeing convolution. The rotation curve of a nuclear disc gives an excellent measure of the central mass-to-light ratio whenever the VPs clearly reveal the narrow, rapidly rotating component associated with the nuclear disc. Steep cusps and seeing convolution both result in central VPs that are dominated by the bulge light, and these VPs barely show the presence of the nuclear disc, impeding measurements of the central rotation velocities of the disc stars. However, if a massive BH is present, the disc compo...

  18. On the possibilities of mass loss from an advective accretion disc around stationary black holes

    CERN Document Server

    Das, Santabrata; Nandi, Anuj; Sarkar, Biplob

    2014-01-01

    We study the coupled disc-jet system around the black hole where the outflow solutions are obtained in terms of the inflow parameters. We observe that an advective accretion disc can eject outflows/jets for wide range of viscosity parameter. However, such possibility is reduced if the cooling is active as the energy dissipative process inside the disc. For mass outflow, we obtain the parameter space spanned by the inflow angular momentum and the viscosity in terms of cooling and quantify the limits of viscosity parameter.

  19. Analysis of tempering stresses in bilayered porcelain discs.

    Science.gov (United States)

    DeHoff, P H; Anusavice, K J

    1992-05-01

    Previous studies of opaque-porcelain/body-porcelain discs have shown that compressive stresses which develop in the porcelain surface by being tempered in air can inhibit the sizes of cracks induced within the surface. The objective of this study was to develop a theoretical model for analysis of transient and residual stresses in opaque-porcelain/body-porcelain discs which were produced under variable cooling conditions. The model incorporates the effects of stress and structural relaxation. Transient and residual stresses were calculated for bilayered porcelain discs 16 mm in diameter and 2 mm in thickness for three opaque-porcelain/body-porcelain combinations. Transient temperature distributions in the discs for simulated convective cooling were calculated by finite-element analysis. Data from microhardness indentations reported by Anusavice et al. (1989) indicate that crack lengths measured for bilayered porcelain discs subjected to slow cooling conditions, for which the model predicted residual tensile stresses, were greater than those combinations for which residual compressive stresses were calculated. Calculated values of residual compressive stress for tempered specimens were considerably higher than those for specimens that were slowly cooled and those that were cooled by free convection. In general, residual stress levels calculated by use of the analytical model were in fairly good agreement with the trends observed for crack lengths and bi-axial flexural strengths reported by Anusavice and Hojjatie (1991). The results of the present study indicate that a visco-elastic model is a viable approach for determination of transient and residual stresses in opaque-porcelain/body-porcelain discs.

  20. Planetary migration in weakly magnetized turbulent discs

    Science.gov (United States)

    Baruteau, C.; Fromang, S.; Nelson, R. P.; Masset, F.

    2011-12-01

    In laminar viscous disc models, the migration of protoplanets embedded in their nascent protoplanetary discs may be directed inwards or outwards, depending on the relative magnitude of the Lindblad and corotation torques. The long-term evolution of the corotation torque is intimately related to diffusion processes inside the planet's horseshoe region. This communication examines the properties of the corotation torque in discs where magnetohydrodynamic (MHD) turbulence develops as a result of the magnetorotational instability (MRI), considering a weak initial toroidal magnetic field. We show that the differential Lindblad torque takes very similar values in MHD turbulent and laminar viscous discs, and there exists an unsaturated corotation torque in MHD turbulent discs.

  1. Radiation from optically thin accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Tylenda, R. (Polska Akademia Nauk, Torun. Pracownia Astrofizyki)

    1981-01-01

    Accretion discs in cataclysmic variables with low rates of mass transfer, M < or approx. 10/sup 16/g s/sup -1/, have outer regions optically thin in continuum. A simple approach that allows one to calculate the radiation spectra from such discs is presented. A great number of disc models has been obtained in order to study the influence of various parameters (accretion rate, outer radius of the disc, inclination angle, mass of the accreting degenerate dwarf, viscosity parameter) of discs on the outgoing continuous spectra, emission lines and the UBV colours.

  2. Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study.

    Science.gov (United States)

    Guehring, Thorsten; Nerlich, Andreas; Kroeber, Markus; Richter, Wiltrud; Omlor, Georg W

    2010-01-01

    The immature disc nucleus pulposus (NP) consists of notochordal cells (NCs). With maturation NCs disappear in humans, to be replaced by chondrocyte-like mature NP cells (MNPCs); this change in cell phenotype coincidences with early signs of disc degeneration. The reasons for NC disappearance are important to understand disc degeneration, but remain unknown, yet. This study investigated, whether loading induced a change from a notochordal nucleus phenotype to a chondrocyte-like one. An in vivo disc compression model with fixateur externe was used in 36 mature rabbits. Discs were compressed for different time periods (1, 28, 56 days), and compared with uncompressed control discs (56 days without treatment), and discs with sham compression (28 days). Nucleus cell phenotype was determined by histology and immunohistochemistry. NCs, but not MNPCs highly expressed bone-morphogenetic-protein 2 and cytokeratin 8, thus NC and MNPC numbers could be determined. A histologic score was used to detect structural endplate changes after compression (28 days). Control and sham compressed discs contained around 70% NCs and 30% MNPCs, to be decreased to 50% after 28-56 days of compression (P < 0.05 vs. controls). Signs of decreased endplate cellularity and increased endplate sclerosis and fibrosis were found after loading. These experiments show that NCs were less resistant to mechanical stress than MNPCs suggesting that increased intradiscal pressures after loading, and limited nutrition through structurally altered endplates could instigate the disappearance of NCs.

  3. The artificial disc: theory, design and materials.

    Science.gov (United States)

    Bao, Q B; McCullen, G M; Higham, P A; Dumbleton, J H; Yuan, H A

    1996-06-01

    Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: discectomy and fusion. Although discectomy and fusion produce a relatively good short-term clinical result in relieving pain, both these surgical treatments alter the biomechanics of the spine, possibly leading to further degeneration of the surrounding tissues and the discs at adjacent levels. Over the past 35 years, a tremendous effort has been made to develop an artificial disc to replace the degenerated disc. The goal is the restoration of the natural biomechanics of the segment after disc excision, thus relieving pain and preventing further degeneration at adjacent segments. However, the artificial disc faces a complex biomechanical environment which makes replication of the biomechanics difficult and long-term survival challenging to designs and materials. The purpose of this article is to examine the factors of importance in designing a disc replacement. Topics covered include the structure and function of the natural disc, the changes that occur with disc degeneration and existing methods of treatment for the degenerative spine. The progress in achieving a functional, long-lasting disc replacement is outlined.

  4. The properties of external accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Pringle, J.E. (Space Telescope Science Inst., Baltimore, MD (USA))

    1991-02-15

    The properties of external accretion discs (discs with a central source of angular momentum) are explored both analytically and numerically. An illustrative example of the effect of a disc of material around a binary star on the stellar separation is considered. We consider a Greens-function-type solution in which an initial ring of matter is put in orbit around the central binary. We find that the solution splits temporally into three parts. First, the disc evolves as a standard accretion disc unaware of the inner boundary condition. Secondly, the disc interacts with the inner boundary and changes its character to become, thirdly, an outflowing disc which is propelled outwards by the source of angular momentum at the centre. (author).

  5. Twisted accretion discs: Pt. 5; Viscous evolution

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. (Max-Planck-Institut fuer Physik und Astrophysik, Garching (Germany, F.R.). Inst. fuer Astrophysik)

    1990-08-15

    The time-dependence of accretion discs with orbits tilted out of the symmetry plane is studied. The effects of mass inflow modulation, and tilt variation at the disc outer edge, are examined for both circumbinary discs and for discs around compact objects. The appendices extend the numerical work to some analytic examples of tilt diffusion and external forcing effects. It is also shown that the disc must not be treated as a rigid tilted object if global angular momentum is to be conserved. These results are relevant to the problem of long-term periodicities of the light curves in Her X1 and {epsilon} Aur, the S-type symmetry of radio jets, warped gas discs in galaxies and polar rings in Neptune. Twisted discs may also arise in star-forming regions. (author).

  6. Three-level cervical disc herniation

    Directory of Open Access Journals (Sweden)

    St. Iencean Andrei

    2015-09-01

    Full Text Available Multilevel cervical degenerative disc disease is well known in the cervical spine pathology, with radicular syndromes or cervical myelopathy. One or two level cervical herniated disc is common in adult and multilevel cervical degenerative disc herniation is common in the elderly, with spinal stenosis, and have the same cause: the gradual degeneration of the disc. We report the case of a patient with two level cervical disc herniation (C4 – C5 and C5 – C6 treated by anterior cervical microdiscectomy both levels and fusion at C5 – C6; after five years the patient returned with left C7 radiculopathy and MRI provided the image of a left C6 – C7 disc herniation, he underwent an anterior microsurgical discectomy with rapid relief of symptoms. Three-level cervical herniated disc are rare in adults, and the anterior microdiscectomy with or without fusion solve this pathology.

  7. Linear perturbations of a Schwarzschild blackhole by thin disc - convergence

    Science.gov (United States)

    Čížek, P.; Semerák, O.

    2012-07-01

    In order to find the perturbation of a Schwarzschild space-time due to a rotating thin disc, we try to adjust the method used by [4] in the case of perturbation by a one-dimensional ring. This involves solution of stationary axisymmetric Einstein's equations in terms of spherical-harmonic expansions whose convergence however turned out questionable in numerical examples. Here we show, analytically, that the series are almost everywhere convergent, but in some regions the convergence is not absolute.

  8. Microscopic kinetic analysis of space-charge induced optical microbunching in a relativistic electron beam

    Directory of Open Access Journals (Sweden)

    Agostino Marinelli

    2010-11-01

    Full Text Available Longitudinal space-charge forces from density fluctuations generated by shot noise can be a major source of microbunching instability in relativistic high brightness electron beams. The gain in microbunching due to this effect is broadband, extending at least up to optical frequencies, where the induced structure on the beam distribution gives rise to effects such as coherent optical transition radiation. In the high-frequency regime, theoretical and computational analyses of microbunching formation require a full three-dimensional treatment. In this paper we address the problem of space-charge induced optical microbunching formation in the high-frequency limit when transverse thermal motion due to finite emittance is included for the first time. We derive an analytical description of this process based on the beam’s plasma dielectric function. We discuss the effect of transverse temperature on the angular distribution of microbunching gain and its connection to the physics of Landau damping in longitudinal plasma oscillations. Application of the theory to a relevant experimental scenario is discussed. The analytical results obtained are then compared to the predictions arising from high resolution three-dimensional molecular dynamics simulations.

  9. Computed tomography of the herniated lumbar disc: diagnostic difficulties and error

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, T.; Treisch, J.; Claussen, C.; Banzer, D.

    1983-01-01

    In 310 computed axial tomograms of the lumbar spine which were studied retrospectively a number of pitfall situations were encountered. These in part were related to technical limitations, in part to degenerative joint disease and to postoperative hypertrophic scar formation. It became evident that the position of the disc within the intervertebral space may vary to a certain degree, a phenomenon not to be mistaken for disc protrusion.

  10. On compensating tune spread induced by space charge in bunched beams

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko V. N.; Wang, G.

    2014-05-09

    Space charge effects play significant role in modern-day accelerators. These effects frequently constrain attainable beam parameters in an accelerator, or, in an accelerator chain. They also could limit the luminosity of hadron colliders operating either at low energies or with a sub-TeV high brightness hadron beams. The latter is applied for strongly cooled proton and ion beams in eRHIC – the proposed future electron-ion collider at Brookhaven National Laboratory. A number of schemes for compensating space charge effects in a coasting (e.g. continuous) hadron beam were proposed and some of them had been tested. Using a proper transverse profile of the electron beam (or plasma column) for a coasting beam would compensate both the tune shift and the tune spread in the hadron beam. But all of these methods do not address the issue of tune spread compensation of a bunched hadron beam, e.g. the tune shift dependence on the longitudinal position inside the bunch. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with miss-matched longitudinal velocity to compensate the space charge induced tune-shift and tune spread. We present a number of practical examples of such system.

  11. Intervertebral disc (IVD): Structure, degeneration, repair and regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Whatley, Benjamin R.; Wen Xuejun, E-mail: xjwen@clemson.edu

    2012-02-01

    Low back pain affects a large portion of the population, resulting in high care costs for therapy and treatment. One primary cause of low back pain is the degeneration of the intervertebral disc (IVD) resulting in the compression of the spinal nerves and adjacent vertebrae. Exact causes of degeneration are unknown, but it is thought that natural aging, and both biological and genetic factors may play a significant role in the degenerative process. Conventional methods to alleviate low back pain include spinal fusion and artificial disc replacement. Traditional treatments through spinal fusion may eliminate pain yet do not restore disc function and lead to further degeneration of adjacent levels by altering disc biomechanics and natural kinematics. Recently, artificial IVD replacements have started to gain interest, with two IVD implants currently approved in the United States. Although these implants facilitate the preservation of motions and disc space height, they are unable to sustain compressive forces due to their lack of elasticity. In addition, the implants may produce wear debris that can cause osteolysis and other deleterious effects. As an alternative to these conventional approaches, tissue engineered IVD constructs offer the advantage of biointegration while preserving the essential attributes of natural motion and disc space restoration. There is a great need for the development of tissue engineered scaffolds that simulate the natural 3D morphology and microenvironment of the targeted tissue. Scaffolds should facilitate biological transport to satisfy nutrition and waste removal requirements within the IVD. The discrete tissue architectures of the nucleus pulposus (NP) and annulus fibrosus (AF) have posed great challenges to IVD tissue engineering. Current attempts have not been able to satisfy the biological functions and/or mechanical properties of native tissue. Therefore, these current scaffolds are far from satisfactory. This review highlights the

  12. Vertebral degenerative disc disease severity evaluation using random forest classification

    Science.gov (United States)

    Munoz, Hector E.; Yao, Jianhua; Burns, Joseph E.; Pham, Yasuyuki; Stieger, James; Summers, Ronald M.

    2014-03-01

    Degenerative disc disease (DDD) develops in the spine as vertebral discs degenerate and osseous excrescences or outgrowths naturally form to restabilize unstable segments of the spine. These osseous excrescences, or osteophytes, may progress or stabilize in size as the spine reaches a new equilibrium point. We have previously created a CAD system that detects DDD. This paper presents a new system to determine the severity of DDD of individual vertebral levels. This will be useful to monitor the progress of developing DDD, as rapid growth may indicate that there is a greater stabilization problem that should be addressed. The existing DDD CAD system extracts the spine from CT images and segments the cortical shell of individual levels with a dual-surface model. The cortical shell is unwrapped, and is analyzed to detect the hyperdense regions of DDD. Three radiologists scored the severity of DDD of each disc space of 46 CT scans. Radiologists' scores and features generated from CAD detections were used to train a random forest classifier. The classifier then assessed the severity of DDD at each vertebral disc level. The agreement between the computer severity score and the average radiologist's score had a quadratic weighted Cohen's kappa of 0.64.

  13. Protective effects of L-selenomethionine on space radiation induced changes in gene expression.

    Science.gov (United States)

    Stewart, J; Ko, Y-H; Kennedy, A R

    2007-06-01

    Ionizing radiation can produce adverse biological effects in astronauts during space travel. Of particular concern are the types of radiation from highly energetic, heavy, charged particles known as HZE particles. The aims of our studies are to characterize HZE particle radiation induced biological effects and evaluate the effects of L-selenomethionine (SeM) on these adverse biological effects. In this study, microarray technology was used to measure HZE radiation induced changes in gene expression, as well as to evaluate modulation of these changes by SeM. Human thyroid epithelial cells (HTori-3) were irradiated (1 GeV/n iron ions) in the presence or in the absence of 5 microM SeM. At 6 h post-irradiation, all cells were harvested for RNA isolation. Gene Chip U133Av2 from Affymetrix was used for the analysis of gene expression, and ANOVA and EASE were used for a determination of the genes and biological processes whose differential expression is statistically significant. Results of this microarray study indicate that exposure to small doses of radiation from HZE particles, 10 and 20 cGy from iron ions, induces statistically significant differential expression of 196 and 610 genes, respectively. In the presence of SeM, differential expression of 77 out of 196 genes (exposure to 10 cGy) and 336 out of 610 genes (exposure to 20 cGy) is abolished. In the presence or in the absence of SeM, radiation from HZE particles induces differential expression of genes whose products have roles in the induction of G1/S arrest during the mitotic cell cycle, as well as heat shock proteins. Some of the genes, whose expressions were affected by radiation from HZE particles and were unchanged in irradiated cells treated with SeM, have been shown to have altered expression levels in cancer cells. The conclusions of this report are that radiation from HZE particles can induce differential expression of many genes, some of which are known to play roles in the same processes that have

  14. MR imaging of herniated lumbar disc : morphologic change between supine and flexed-prone position

    Energy Technology Data Exchange (ETDEWEB)

    Seong, Jin Yong; Lee, Seung Ro; Moon, Won Jin; Park, Dong Woo; Hahm, Chang Kok [Hanyang Univ., Seoul (Korea, Republic of); Kim, Sung Tae [Sungnam Inha Hospital, Sungnam (Korea, Republic of)

    1997-12-01

    The purpose of this study is to determine morphologic change in a herniated lumbar disc, as seen on MR imaging according to position change (supine and flexed-prone positions). A hundred and twenty-two patients with herniated lumbar discs, as seen on supine MR imaging, underwent repeat MR imaging in the flexed-prone position; 100 patients, who showed more than 2 deg of flexion angle difference, were included in this study. Sixty-two were men and thirty-eight were women, and their ages ranged from 13 to 59 (mean, 30) years. Disc degeneration was graded as 1,2 or 3, depending on the area of decreased signal intensity seen on a T2-weighted MR image. Difference in the angle of flexion is defined as the angle difference of lumbar curvature, calculated by the Begg-falconer method in supine and flexed-prone positions. Morphologic changes in herniated discs in difference positions were analysed on the basis of shape change of anterior epidural spaces, thecal sacs and posterior margins of herniated discs, and classified as either A (not changed) or B (changed). Group B was subtyped as type I (decreased herniation without change of shape), type II (decreased herniation with change of shape) or type III (increased disc herniation). We statistically analysed correlations between a patient`s age, morphologic change in a herniated disc in different positions, and degree of degeneration in such a disc, as well as the correlation between morphologic change in a herniated disc in different positions and the degree of the flexion angle. In the flexed-prone position, which is similar to that used during surgery, MRI can reveal various morphologic changes in a herniated lumbar disc, mainly decreased herniation, and is helpful in making decisions related to surgery. (author). 12 refs., 2 tabs., 4 figs.

  15. Centrifugally exhausting discs: an inverse process of disc-like accretion

    Energy Technology Data Exchange (ETDEWEB)

    Kaburaki, O.

    1989-03-01

    A disc-like mass-loss process from rapidly rotating, highly magnetized objects is investigated. Such a disc may be considered as an inverse-type of magnetized accretion discs. The disc plasma flows out radially with the Alfven velocity while it rotates, in the main part of the disc, with Keplerian velocity. The magnetic stress transfers angular momentum from the central spinner to the disc. A considerable fraction of the rotational energy extracted in association with the angular momentum is liberated in the disc through the (effective) Joule dissipation. An almost self-consistent set of analytic expressions is proposed as a solution to the steady-state, resistive MHD equations which are fairly simplified by the assumption of thin disc. The possibility of finding such discs around young neutron stars is briefly discussed with reference to SN 1987A.

  16. Grain charging in protoplanetary discs

    CERN Document Server

    Ilgner, Martin

    2011-01-01

    Recent work identified a growth barrier for dust coagulation that originates in the electric repulsion between colliding particles. Depending on its charge state, dust material may have the potential to control key processes towards planet formation such as MHD (magnetohydrodynamic) turbulence and grain growth which are coupled in a two-way process. We quantify the grain charging at different stages of disc evolution and differentiate between two very extreme cases: compact spherical grains and aggregates with fractal dimension D_f = 2. Applying a simple chemical network that accounts for collisional charging of grains, we provide a semi-analytical solution. This allowed us to calculate the equilibrium population of grain charges and the ionisation fraction efficiently. The grain charging was evaluated for different dynamical environments ranging from static to non-stationary disc configurations. The results show that the adsorption/desorption of neutral gas-phase heavy metals, such as magnesium, effects the ...

  17. Superhumps, resonances and accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Whitehurst, R.; King, A. (Leicester Univ. (UK). Dept. of Astronomy)

    1991-03-01

    The structure of accretion discs within binary systems is shown to be influenced by the excitation of resonances within the disc. Of particular importance is that near the 3:1 commensurability with the stars' orbit. This can be used to explain the superhump phenomenon of SU Ursae Majoris dwarf novae in superoutburst. This resonance can only appear for mass ratios which satisfy M{sub 2}/M{sub 1} < {approx equal} 0.25-0.33: for larger mass ratios the available resonances are weaker and of the wrong form to produce the superhump phenomenon. The mass-transfer stream is shown to be an important contributor to the growth rate of the resonance. (author).

  18. A comparison of mutations induced by accelerated iron particles versus those induced by low earth orbit space radiation in the FEM-3 gene of Caenorhabditis elegans

    Science.gov (United States)

    Hartman, P. S.; Hlavacek, A.; Wilde, H.; Lewicki, D.; Schubert, W.; Kern, R. G.; Kazarians, G. A.; Benton, E. V.; Benton, E. R.; Nelson, G. A.

    2001-01-01

    The fem-3 gene of Caenorhabditis elegans was employed to determine the mutation frequency as well as the nature of mutations induced by low earth orbit space radiation ambient to Space Shuttle flight STS-76. Recovered mutations were compared to those induced by accelerated iron ions generated by the AGS synchrotron accelerator at Brookhaven National Laboratory. For logistical reasons, dauer larvae were prepared at TCU, transported to either Kennedy Space Center or Brookhaven National Laboratory, flown in space or irradiated, returned to TCU and screened for mutants. A total of 25 fem-3 mutants were recovered after the shuttle flight and yielded a mutation frequency of 2.1x10(-5), roughly 3.3-fold higher than the spontaneous rate of 6.3x10(-6). Four of the mutations were homozygous inviable, suggesting that they were large deletions encompassing fem-3 as well as neighboring, essential genes. Southern blot analyses revealed that one of the 25 contained a polymorphism in fem-3, further evidence that space radiation can induce deletions. While no polymorphisms were detected among the iron ion-induced mutations, three of the 15 mutants were homozygous inviable, which is in keeping with previous observations that high LET iron particles generate deficiencies. These data provide evidence, albeit indirect, that an important mutagenic component of ambient space radiation is high LET charged particles such as iron ions.

  19. Eclipse mapping of accretion discs

    OpenAIRE

    Baptista, Raymundo

    2000-01-01

    The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations. I summarize the most important results obtained to date and discuss how they have helped to improve our understanding of accretion physics, from testing the theoretical radial brightness temperature dist...

  20. Diversity and Stability Study on Rice Mutants Induced in Space Environment

    Institute of Scientific and Technical Information of China (English)

    Wei-Hong Lu; Xin-Zhu Wang; Qi Zheng; Shuang-Hong Guan; Ping Xin; Ye-Qing Sun

    2008-01-01

    To further study the characteristics of changes on the molecular level of rice mutants induced in space environment, we analyzed proteins in leaves and seeds of four rice mutants (two high-tillering and two low-tillering) in the 8th and 9th generations after a 15-day spaceflight, and compared with their ground controls by two-dimentional polyacrylamide gel electrophoresis and reverse phase liquid chromatography (RPLC). In addition, the albumin, globulin, prolamine, glutelin, and amylose of the mutant seeds were analyzed by RPLC and ultra-violet spectrometry. The results showed that the low-abundance proteins of leaves in the peak tillering stage are more likely to be induced compared with their corresponding controls. The albumin, globulin, and prolamine of the mutant seeds revealed changes when compared with their controls, and the characteristics of changes in different mutants were stably inherited in the 8th and 9th generations, suggesting that they can be used as biomarkers to identity the mutants induced by spaceflight. Moreover, two proteins (SSP9111 and SSP6302) were found to be expressed with high intensity (two-fold change) in different mutants, which were both correlated with photosystem according to mass spectrometry and database searching.

  1. Mitigation of Railway Traffic Induced Vibrations: The Influence of Barriers in Elastic Half-Space

    Directory of Open Access Journals (Sweden)

    Michele Buonsanti

    2009-01-01

    Full Text Available In this paper, the problem of vibrations induced by trains and their propagation through the soil is studied. Particular attention is focused on the vibration induced by trains in motion and on the effects of such vibrations on the foundations of buildings in proximity of the tracks. The interaction between propagating waves induced by trains in motion and buildings foundations is a problem which does not admit a straightforward analytical solution; thus a solution is given by the use of a model based on the finite elements method. Firstly, we analyze the theoretical aspects of the problem by considering constant or harmonic loads moving along a straight railway track; then, we define a transfer function soil-railway and the response function of the entire system. The study aims to address the wave propagation in an elastic semi-space and the presence in the ground of a discontinuity element, such as a barrier of a given depth is considered. The efficiency variation of barriers is analyzed in function of the different materials used, and different numerical simulations are analyzed in order to study how the wave propagation and the track-soil interaction are influenced by the membrane, seen as damping barrier.

  2. The dispersal of protoplanetary discs

    Directory of Open Access Journals (Sweden)

    Ercolano Barbara

    2013-04-01

    Full Text Available Protoplanetary discs are a natural consequence of the star formation process and as such are ubiquitous around low-mass stars. They are fundamental to planet formation as they hold the reservoir of material from which planets form. Their evolution and final dispersal and the timescales that regulate these process are therefore of particular interest. In this contribution I will review the observational evidence for the dispersal of discs being dominated by two timescales and for the final dispersal to occur quickly and from the inside out. I will discuss the current theoretical models, including X-ray photoevaporation, showing that the latter provides a natural explanation to the observed behaviour and review supporting and contrasting evidence. I will finally introduce a new mechanism based on the interaction between planet formation and photoevaporation that may explain a particular class of transition discs with large inner holes and high accretion rates that are problematic for photoevaporation models and planet formation models alone.

  3. The biomechanical research on the changes of pressures in the C7/T1 intervertebral space after C5/6 cervical artificial disc replacement%C5/6人工颈椎间盘置换后C7/T1椎间隙压力变化的生物力学研究

    Institute of Scientific and Technical Information of China (English)

    李康华; 李思鸿; 李国军; 张俊; 黄跃平

    2009-01-01

    Objective To explore the stress changes of C7/T1 intervertebral space pre-and post C5/6 discectomy and artificial disc replacement.Method Eleven healthy adult fresh muhisegmental cadaveric cervical spine segments were utilized in this investigation and biomechanically evaluated under the following C5/6 conditions:intact spine,discectomy,and Bryan Disc prosthesis implantation.The load,of neutrality and pure moments of axial,flexion,extension,and lateral bending were applied on each group.The stress changes of the inferior (C7/T1)interverlebral space was detected by modified cyclo-shaped miniature transducer.Result Under axial,anteflexion,and lateral bending loading,the discectomy indicated a significant increase in the stress of the inferiorer(C7/T1)intervertebral space,compared to intact condition and CADR(P<0.05).Under extension loading,the discectomy indicated an increase in the stress of the inferiorer(C7/T1)intervertebral space,compared to intact condition(P>0.05).Under axial,flexion,extension and lateral bending loading,the Bryan Disc prosthesis implantation indicate minor increase of the stress in the inferior(C7/T1)intervertebral space to intact condition(P>0.05).Conclusion There was no difference between the C5/6 ADR and intact spine group.The discectomy of the Cs/6 can increase the stress of the C7/T1 intervertebral spaoe.%目的 了解G5/6椎间盘髓核摘除、人工颈椎间盘置换对C7/T1椎间隙内压力的影响.方法 11具新鲜青壮年颈椎尸体标本.按测试的先后次序分为C5/6椎间盘完整组、C5/6椎间盘髓核摘除组和C5/6Bryan人工颈椎间盘置换组,在颈椎标本上施加轴向、侧弯、后伸、前屈分级载荷,测量各组C7/T1椎间隙内的压力并进行分析比较.结果 (1)在轴向、前屈、侧弯三种工况相同载荷下,C5/6椎间盘髓核摘除组C7/T1椎间隙内的压力大于人工椎间盘组与椎间盘完整组(P0.05).(3)C5/6人工椎间盘置换组C7/T1椎间隙内的压力在

  4. Intraosseous disc prolapse: A diagnostic puzzle

    Directory of Open Access Journals (Sweden)

    Parasnis Rajesh

    2006-01-01

    Full Text Available Background : Schmorl′s node or intraosseous disc prolapse is herniation of the nucleus pulposus material through the vertebral end plates. Presence of Schmorl′s nodes as end plate lesions following trauma, tumours and osteoporosis further complicates diagnosis. The present study was done to understand diagnosis and approach to management of symptomatic Schmorl′s nodes. Methods : During a period of three years we came across 14 patients who presented with severe back pain. Conventional radiographs, CT Scans and MRI showed the presence of end plate lesions with varied radiological appearance. The first group, comprising of seven patients had lytic lesions without any sclerosis on only one side of the intervertebral disc as seen on the CT scan. The second group comprising of five patients had sclerotic lesions with new bone formation associated with disc space reduction. The two patients in the third group showed a combined lytic and sclerotic lesion without any soft tissue changes. MRI of eleven patients revealed hypointense lesion on T 1 and T 2 weighted images with surrounding zone of hyper intensity on T 2 weighted images. The remaining three patients, did not have this hyper intense zone on T 2 weighted images . In five patients multiple Schmorl′s nodes were observed. Diagnosis of symptomatic Schmorl′s nodes was mainly done by exclusion. All patients were given rest and anti-inflammatory drugs followed by exercises. Results : The first two groups of patients responded to the treatment and had complete relief of symptoms but both the patients in third group had persistent symptoms. MRI repeated after eight weeks showed an enhancing lesion with prevertebral soft tissue. A transpedicular core biopsy proved the lesion to be tuberculosis in one patient. Anti Koch′s therapy was promptly started and follow up study showed resolution of the lesions. At the end of the study period all the patients were asymptomatic and returned to their

  5. Differentiating induced and natural seismicity using space-time-magnitude statistics applied to the Coso Geothermal field

    Science.gov (United States)

    Schoenball, Martin; Davatzes, Nicholas C.; Glen, Jonathan M. G.

    2015-01-01

    A remarkable characteristic of earthquakes is their clustering in time and space, displaying their self-similarity. It remains to be tested if natural and induced earthquakes share the same behavior. We study natural and induced earthquakes comparatively in the same tectonic setting at the Coso Geothermal Field. Covering the preproduction and coproduction periods from 1981 to 2013, we analyze interevent times, spatial dimension, and frequency-size distributions for natural and induced earthquakes. Individually, these distributions are statistically indistinguishable. Determining the distribution of nearest neighbor distances in a combined space-time-magnitude metric, lets us identify clear differences between both kinds of seismicity. Compared to natural earthquakes, induced earthquakes feature a larger population of background seismicity and nearest neighbors at large magnitude rescaled times and small magnitude rescaled distances. Local stress perturbations induced by field operations appear to be strong enough to drive local faults through several seismic cycles and reactivate them after time periods on the order of a year.

  6. Gravitational instabilities in a protosolar-like disc - II. Continuum emission and mass estimates

    Science.gov (United States)

    Evans, M. G.; Ilee, J. D.; Hartquist, T. W.; Caselli, P.; Szűcs, L.; Purser, S. J. D.; Boley, A. C.; Durisen, R. H.; Rawlings, J. M. C.

    2017-09-01

    Gravitational instabilities (GIs) are most likely a fundamental process during the early stages of protoplanetary disc formation. Recently, there have been detections of spiral features in young, embedded objects that appear consistent with GI-driven structure. It is crucial to perform hydrodynamic and radiative transfer simulations of gravitationally unstable discs in order to assess the validity of GIs in such objects, and constrain optimal targets for future observations. We utilize the radiative transfer code lime (Line modelling Engine) to produce continuum emission maps of a 0.17 M⊙ self-gravitating protosolar-like disc. We note the limitations of using lime as is and explore methods to improve upon the default gridding. We use casa to produce synthetic observations of 270 continuum emission maps generated across different frequencies, inclinations and dust opacities. We find that the spiral structure of our protosolar-like disc model is distinguishable across the majority of our parameter space after 1 h of observation, and is especially prominent at 230 GHz due to the favourable combination of angular resolution and sensitivity. Disc mass derived from the observations is sensitive to the assumed dust opacities and temperatures, and therefore can be underestimated by a factor of at least 30 at 850 GHz and 2.5 at 90 GHz. As a result, this effect could retrospectively validate GIs in discs previously thought not massive enough to be gravitationally unstable, which could have a significant impact on the understanding of the formation and evolution of protoplanetary discs.

  7. Induced higher-derivative massive gravity on a 2-brane in 4D Minkowski space

    Directory of Open Access Journals (Sweden)

    D. Bazeia

    2015-03-01

    Full Text Available In this paper we revisit the problem of localizing gravity in a 2-brane embedded in a 4D Minkowski space to address induction of high derivative massive gravity. We explore the structure of propagators to find well-behaved higher-derivative massive gravity induced on the brane. Exploring a special case in the generalized mass term of the graviton propagator we find a model of consistent higher order gravity with an additional unitary massive spin-2 particle and two massless particles: one spin-0 particle and one spin-1 particle. The condition for the absence of tachyons is satisfied for both ‘right’ and ‘wrong’ signs of the Einstein–Hilbert term on the 2-brane. We also find the Pauli–Fierz mass term added to the new massive gravity in three dimensions and recover the low-dimensional DGP model.

  8. Induced higher-derivative massive gravity on a 2-brane in 4D Minkowski space

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D. [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, 58051-970 João Pessoa, Paraíba (Brazil); Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil); Brito, F.A., E-mail: fabrito@df.ufcg.edu.br [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, 58051-970 João Pessoa, Paraíba (Brazil); Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil); Costa, F.G. [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, 58051-970 João Pessoa, Paraíba (Brazil); Instituto Federal de Educação, Ciência e Tecnologia da Paraíba (IFPB), Campus Picuí (Brazil)

    2015-03-06

    In this paper we revisit the problem of localizing gravity in a 2-brane embedded in a 4D Minkowski space to address induction of high derivative massive gravity. We explore the structure of propagators to find well-behaved higher-derivative massive gravity induced on the brane. Exploring a special case in the generalized mass term of the graviton propagator we find a model of consistent higher order gravity with an additional unitary massive spin-2 particle and two massless particles: one spin-0 particle and one spin-1 particle. The condition for the absence of tachyons is satisfied for both ‘right’ and ‘wrong’ signs of the Einstein–Hilbert term on the 2-brane. We also find the Pauli–Fierz mass term added to the new massive gravity in three dimensions and recover the low-dimensional DGP model.

  9. A Novel Statistical Channel Model for Turbulence-Induced Fading in Free-Space Optical Systems

    CERN Document Server

    Aminikashani, Mohammadreza; Kavehrad, Mohsen

    2015-01-01

    In this paper, we propose a new probability distribution function which accurately describes turbulence-induced fading under a wide range of turbulence conditions. The proposed model, termed Double Generalized Gamma (Double GG), is based on a doubly stochastic theory of scintillation and developed via the product of two Generalized Gamma (GG) distributions. The proposed Double GG distribution generalizes many existing turbulence channel models and provides an excellent fit to the published plane and spherical waves simulation data. Using this new statistical channel model, we derive closed form expressions for the outage probability and the average bit error as well as corresponding asymptotic expressions of free-space optical communication systems over turbulence channels. We demonstrate that our derived expressions cover many existing results in the literature earlier reported for Gamma-Gamma, Double-Weibull and K channels as special cases.

  10. Simulation of crack coalescence mechanism underneath single and double disc cutters by higher order displacement discontinuity method

    Institute of Scientific and Technical Information of China (English)

    Mohammad Fatehi Marji

    2015-01-01

    The present research is focused on the numerical crack coalescence analysis of the micro-cracks and cracks produced during the cutting action of TBM disc cutters. The linear elastic fracture mechanics (LEFM) concepts and the maximum tangential stress criterion are used to investigate the micro crack propagation and its direction underneath the excavating discs. A higher order displacement discontinuity method with quadratic displacement discontinuity elements is used to estimate the stress intensity factors near the crack tips. Rock cutting mechanisms under single and double type discs are simulated by the proposed numerical method. The main purposes of the present modeling are to simulate the chip formation process of indented rocks by single and double discs. The effects of specific disc parameters (except speed) on the thrust force Ft, the rolling force Fr, and the specific energy ES are investigated. It has been shown that the specific energy (energy required to cut through a unit volume of rock) of the double disc is less than that of the single disc. Crack propagation in rocks under disc cutters is numerically modeled and the optimum ratio of disc spacing S to penetration depth Pd (i.e. S/Pd ratio) of about 10 is obtained, which is in good agreement with the theoretical and experimental results cited in the literature.

  11. Localization of cathepsins G and L in spontaneous resorption of intervertebral discs in a rat experimental model.

    Science.gov (United States)

    Meng, W; Yonenobu, K; Ariga, K; Nakase, T; Okuda, S; Obata, K; Yoshikawa, H

    2001-12-01

    To determine the involvement of cathepsins G and L in the mechanism of spontaneous resorption of herniated intervertebral discs, localization of these cathepsins in this process was examined immunohistochemically using a rat model of autologous transplantation of coccygeal discs. Rat coccygeal discs were resected and autotransplanted into the subcutaneous space of the skin of the back. Paraffin-embedded sections of intervertebral disc tissue, harvested at various post-transplantational periods, were immunohistochemically stained with antibodies for cathepsin G, cathepsin L, MMP-1, MMP-3 and ED-2. The number of positive cells was counted in each part of the transplanted discs. Immunolocalization of cathepsins G and L in various types of disc cells was first observed early in the post-transplantation period. From two days after the operation, histology showed invasion by granulation tissue, with many macrophages, in all sections. Subsequently, the number of macrophages in granulation tissue was observed to increase, along with a gradual increase in the percentage of cells positive for MMP-1 and MMP-3. In addition to the ability of cathepsins G and L to degrade major extracellular matrix components of intervertebral discs, cathepsin G is capable of activating latent pro-MMPs. The up-regulation of cathepsins G and L in the intervertebral disc tissue in this spontaneous resorption model suggests that these proteinases may be involved in degradation of extracellular matrix, leading to the natural resorption of herniated discs.

  12. The circumstellar disc in the Bok globule CB 26: Multi-wavelength observations and modelling of the dust disc and envelope

    CERN Document Server

    Sauter, J; Launhardt, R; Padgett, D L; Stapelfeldt, K R; Pinte, C; Duchêne, G; Ménard, F; McCabe, C -E; Pontoppidan, K; Dunham, M; Bourke, T -L; Chen, J -H

    2009-01-01

    Circumstellar discs are expected to be the nursery of planets. Grain growth within such discs is the first step in the planet formation process. The Bok globule CB 26 harbours such a young disc. We present a detailed model of the edge-on circumstellar disc and its envelope in the Bok globule CB 26. The model is based on HST near-infrared maps in the I, J, H, and K bands, OVRO and SMA radio maps at 1.1mm, 1.3mm and 2.7mm, and the spectral energy distribution (SED) from 0.9 microns to 3mm. New photometric and spectroscopic data from the Spitzer Space Telescope and the Caltech Submilimeter Observatory have been obtained and are part of our analysis. Using the self-consistent radiative transfer code MC3D, the model we construct is able to discriminate parameter sets and dust properties of both its parts, namely envelope and disc. We find that the disc has an inner hole with a radius of 45 +/- 5 AU. Based on a dust model including silicate and graphite the maximum grain size needed to reproduce the spectral millim...

  13. Induced polarization dependence on pore space geometry: Empirical observations and mechanistic predictions

    Science.gov (United States)

    Weller, A.; Slater, L. D.

    2015-12-01

    We use an extensive database to compare empirical observations and previously proposed empirical models against recently developed mechanistic formulations for the induced polarization (IP) response in porous media as a function of pore space geometry and interfacial chemistry. These comparisons support the argument that the pore-volume normalized internal surface (Spor) is the most important geometric parameter influencing the polarization. The specific polarizability derived from the empirical relationship between imaginary conductivity σ″ and Spor is independent of the porosity. By contrast, equivalent specific polarizability terms in recently proposed mechanistic models are found to be significantly correlated with porosity, and thus do not appear to represent an interfacial chemistry factor independent of the pore space geometry. Furthermore, the database shows no evidence for a significant decrease in the counterion mobility of clayey materials relative to clay-free materials, as postulated in recent studies. On the contrary, a single value of cp is consistent with no significant differences in ionic mobility given that all samples were saturated with a NaCl solution close to a common salinity of about 100 mS/m.

  14. Extremely Severe Space Weather and Geomagnetically Induced Currents in Regions with Locally Heterogeneous Ground Resistivity

    Science.gov (United States)

    Fujita, Shigeru; Kataoka, Ryuho; Pulkkinen, Antti; Watari, Shinichi

    2016-01-01

    Large geomagnetically induced currents (GICs) triggered by extreme space weather events are now regarded as one of the serious natural threats to the modern electrified society. The risk is described in detail in High-Impact, Low-Frequency Event Risk, A Jointly-Commissioned Summary Report of the North American Electric Reliability Corporation and the US Department of Energy's November 2009 Workshop, June 2010. For example, the March 13-14,1989 storm caused a large-scale blackout affecting about 6 million people in Quebec, Canada, and resulting in substantial economic losses in Canada and the USA (Bolduc 2002). Therefore, European and North American nations have invested in GIC research such as the Solar Shield project in the USA (Pulkkinen et al. 2009, 2015a). In 2015, the Japanese government (Ministry of Economy, Trade and Industry, METI) acknowledged the importance of GIC research in Japan. After reviewing the serious damages caused by the 2011 Tohoku-Oki earthquake, METI recognized the potential risk to the electric power grid posed by extreme space weather. During extreme events, GICs can be concerning even in mid- and low-latitude countries and have become a global issue.

  15. A review and comparative analysis of the biological damage induced during space flight by HZE particles and space hadrons.

    Science.gov (United States)

    Akoev, I G; Yurov, S S; Akoev, B I

    1981-01-01

    We have studied the somatic and genetic effects of heavy ions (HZE particles) and the very high energy hadrons of space radiation on various organisms ranging in complexity from bacteriophage to man. Experimental data were obtained in space, on high mountains and in a proton accelerator at energies of 76 GeV. In all these experiments local micro- and macroradiational damage was observed. This damage was characterized by severity over large local regions and for the most part was due to cascades of secondary particle bundles resulting from the collision of very high energy space hadrons with atomic nuclei rather than from cellular hits from relatively low energy single HZE particles. At present there does not appear to be any effective way to provide shielding against these cosmic hadrons.

  16. Biomechanical study of intervertebral disc degeneration

    OpenAIRE

    González Guitiérrez, Ramiro Arturo

    2012-01-01

    Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend and torsion loads, statically or dynamically, with load magnitudes corresponding to the physiological range. However, traditional testing does...

  17. DSC Study of Collagen in Disc Disease

    OpenAIRE

    S. Skrzyński; Sionkowska, A.; Marciniak, A.

    2009-01-01

    Differential scanning calorimetry (DSC) has been used to estimate the effect of disc disease on the collagen helix-coil transition and morphology for tissue extracted from patients during surgical operation. Forty discs were obtained from patients with degenerative disc disease undergoing surgery for low back pain. The patients were in the age between 20 and 70 years old. The specimens were kept wet during DSC experiment. The data allow the comparison between thermal stability of collagen ti...

  18. Biomechanical study of intervertebral disc degeneration

    OpenAIRE

    González Guitiérrez, Ramiro Arturo

    2012-01-01

    Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend and torsion loads, statically or dynamically, with load magnitudes corresponding to the physiological range. However, traditional testing does...

  19. The Roles of Discs for Planetary Systems

    CERN Document Server

    Yeh, L C; Yeh, Li-Chin; Jiang, Ing-Guey

    2007-01-01

    It is known that the discs are detected for some of the extra-solar planetary systems. It is also likely that there was a disc mixing with planets and small bodies while our Solar System was forming. From our recent results, we conclude that the discs play two roles: the gravity makes planetary systems more chaotic and the drag makes planetary systems more resonant.

  20. DISC1 genetics, biology and psychiatric illness

    OpenAIRE

    2013-01-01

    Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects u...

  1. Transabdominal sonography of lumbar intervertebral discs and intraspinal structures

    Energy Technology Data Exchange (ETDEWEB)

    Toelly, E.

    1984-11-01

    This paper reports a prospective study on 64 patients in whom sonography was used to diagnose pathological changes in lumbar discs and intraspinal space occupying lesions; the results were compared with myelography and computer assisted tomography (CAT). The sonography device used was a mechanical sector scanner with a medium focused transducer with a frequency of 3.5 MHz. The normal and pathological anatomy as shown by ultrasound was correlated to the known anatomy of CAT-scanning; the nerve roots, the dural sac and the intervertebral disc were recognizable in sonography and in CAT. The extent of an intraspinal lesion beyond the upper and lower limiting planes of the intervertebral discs were not demonstrable by ultrasound. The sonographic study was at least partially successful in 55 of 64 patients (86%). It failed in 14% (9 cases) because of obesity or because of diminution of the intervertebral space. The study revealed a specifity and sensitivity of transabdominal spinal sonography of 0.86 respectively 0.84.

  2. The circumstellar disc in the Bok globule CB 26. Multi-wavelength observations and modelling of the dust disc and envelope

    Science.gov (United States)

    Sauter, J.; Wolf, S.; Launhardt, R.; Padgett, D. L.; Stapelfeldt, K. R.; Pinte, C.; Duchêne, G.; Ménard, F.; McCabe, C.-E.; Pontoppidan, K.; Dunham, M.; Bourke, T. L.; Chen, J.-H.

    2009-10-01

    Context: Circumstellar discs are expected to be the nursery of planets. Grain growth within such discs is the first step in the planet formation process. The Bok globule CB 26 harbours such a young disc. Aims: We present a detailed model of the edge-on circumstellar disc and its envelope in the Bok globule CB 26. Methods: The model is based on HST near-infrared maps in the I, J, H, and K bands, OVRO and SMA radio maps at 1.1 mm, 1.3 mm and 2.7 mm, and the spectral energy distribution (SED) from 0.9 {μ m} to 3 mm. New photometric and spectroscopic data from the Spitzer Space Telescope and the Caltech Submilimeter Observatory are also part of our analysis. Using the self-consistent radiative transfer code MC3D, the model we construct is able to discriminate between parameter sets and dust properties of both envelope and disc. Results: We find that the data are fit by a disc that has an inner hole with a radius of 45±5 AU. Based on a dust model including silicate and graphite, the maximum grain size needed to reproduce the spectral millimetre index is 2.5 {μ m}. Features seen in the near-infrared images, dominated by scattered light, can be described as a result of a rotating envelope. Conclusions: Successful employment of ISM dust in both the disc and envelope hint that grain growth may not yet play a significant role for the appearance of this system. A large inner hole implies that CB 26 is a circumbinary disc.

  3. Two-dimensional inversion of spectral induced polarization data using MPI parallel algorithm in data space

    Institute of Scientific and Technical Information of China (English)

    Zhang Zhi-Yong; Tan Han-Dong; Wang Kun-Peng; Lin Chang-Hong; Zhang Bin; Xie Mao-Bi

    2016-01-01

    Traditional two-dimensional (2D) complex resistivity forward modeling is based on Poisson’s equation but spectral induced polarization (SIP) data are the coprod-ucts of the induced polarization (IP) and the electromagnetic induction (EMI) effects. This is especially true under high frequencies, where the EMI effect can exceed the IP effect. 2D inversion that only considers the IP effect reduces the reliability of the inver-sion data. In this paper, we derive differential equations using Maxwell’s equations. With the introduction of the Cole–Cole model, we use thefi nite-element method to conduct 2D SIP forward modeling that considers the EMI and IP effects simultaneously. The data-space Occam method, in which different constraints to the model smoothness and parametric boundaries are introduced, is then used to simultaneously obtain the four parameters of the Cole–Cole model using multi-array electricfi eld data. This approach not only improves the stability of the inversion but also signifi cantly reduces the solution ambiguity. To improve the computational effi ciency, message passing interface program-ming was used to accelerate the 2D SIP forward modeling and inversion. Synthetic da-tasets were tested using both serial and parallel algorithms, and the tests suggest that the proposed parallel algorithm is robust and effi cient.

  4. Two-dimensional inversion of spectral induced polarization data using MPI parallel algorithm in data space

    Science.gov (United States)

    Zhang, Zhi-Yong; Tan, Han-Dong; Wang, Kun-Peng; Lin, Chang-Hong; Zhang, Bin; Xie, Mao-Bi

    2016-03-01

    Traditional two-dimensional (2D) complex resistivity forward modeling is based on Poisson's equation but spectral induced polarization (SIP) data are the coproducts of the induced polarization (IP) and the electromagnetic induction (EMI) effects. This is especially true under high frequencies, where the EMI effect can exceed the IP effect. 2D inversion that only considers the IP effect reduces the reliability of the inversion data. In this paper, we derive differential equations using Maxwell's equations. With the introduction of the Cole-Cole model, we use the finite-element method to conduct 2D SIP forward modeling that considers the EMI and IP effects simultaneously. The data-space Occam method, in which different constraints to the model smoothness and parametric boundaries are introduced, is then used to simultaneously obtain the four parameters of the Cole—Cole model using multi-array electric field data. This approach not only improves the stability of the inversion but also significantly reduces the solution ambiguity. To improve the computational efficiency, message passing interface programming was used to accelerate the 2D SIP forward modeling and inversion. Synthetic datasets were tested using both serial and parallel algorithms, and the tests suggest that the proposed parallel algorithm is robust and efficient.

  5. Accretion Discs Show Their True Colours

    Science.gov (United States)

    2008-07-01

    Quasars are the brilliant cores of remote galaxies, at the hearts of which lie supermassive black holes that can generate enough power to outshine the Sun a trillion times. These mighty power sources are fuelled by interstellar gas, thought to be sucked into the hole from a surrounding 'accretion disc'. A paper in this week's issue of the journal Nature, partly based on observations collected with ESO's Very Large Telescope, verifies a long-standing prediction about the intensely luminous radiation emitted by these accretion discs. Uncovering the disc ESO PR Photo 21/08 Uncovering the inner disc "Astronomers were puzzled by the fact that the best models of these discs couldn't quite be reconciled with some of the observations, in particular, with the fact that these discs did not appear as blue as they should be," explains lead-author Makoto Kishimoto. Such a discrepancy could be the signal that there was something very wrong with the models. With his colleagues, he investigated this discrepancy by studying the polarised light from six quasars. This enabled them to demonstrate that the disc spectrum is as blue as predicted. "The crucial observational difficulty here has been that the disc is surrounded by a much larger torus containing hot dust, whose light partly outshines that of the disc," says Kishimoto. "Because the light coming from the disc is scattered in the disc vicinity and thus polarised, by observing only polarised light from the quasars, one can uncover the buried light from the disc." In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disc in infrared light. The observations were done with the FORS and ISAAC instruments on one of the 8.2-m Unit Telescopes of ESO's Very Large Telescope, located in the Atacama

  6. Computing Decoupled Residuals for Compact Disc Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Andersen, Palle

    2006-01-01

    In order to improve Compact Disc Players playability regarding playing Compact Discs with surface faults, like scratches and fingerprints etc, the attention has been put on fault tolerant control schemes. Almost every of those methods are based on fault detection. The standard approach is to use...... a pair of residuals generated by Compact Disc Player. However, these residuals depend on the performance of position servos in the Compact Disc Player. In other publications of the same authors a pair of decoupled residuals is derived. However, the computation of these alternative residuals has been...

  7. Evolution of Accretion Discs around a Kerr Black Hole using Extended Magnetohydrodynamics

    CERN Document Server

    Foucart, Francois; Gammie, Charles F; Quataert, Eliot

    2015-01-01

    Black holes accreting well below the Eddington rate are believed to have geometrically thick, optically thin, rotationally supported accretion discs in which the Coulomb mean free path is large compared to $GM/c^2$. In such an environment, the disc evolution may differ significantly from ideal magnetohydrodynamic predictions. We present non-ideal global axisymmetric simulations of geometrically thick discs around a rotating black hole. The simulations are carried out using a new code ${\\rm\\it grim}$, which evolves a covariant extended magnetohydrodynamics model derived by treating non-ideal effects as a perturbation of ideal magnetohydrodynamics. Non-ideal effects are modeled through heat conduction along magnetic field lines, and a difference between the pressure parallel and perpendicular to the field lines. The model relies on an effective collisionality in the disc from wave-particle scattering and velocity-space (mirror and firehose) instabilities. We find that the pressure anisotropy grows to match the ...

  8. Self-consistent response of a galactic disc to vertical perturbations

    CERN Document Server

    Saha, K; Saha, Kanak; Jog, Chanda J.

    2006-01-01

    We study the self-consistent, linear response of a galactic disc to vertical perturbations as induced say by a tidal interaction. We calculate the self-gravitational potential corresponding to a non-axisymmetric, self-consistent density response of the disc using the Green's function method. The response potential is shown to oppose the perturbation potential because the self-gravity of the disc resists the imposed potential, and this resistence is stronger in the inner parts of a galactic disc. For the m=1 azimuthal wavenumber, the disc response opposes the imposed perturbation upto a radius that spans a range of 4-6 disc scale-lengths, so that the disc shows a net warp only beyond this region. This physically explains the well-known but so far unexplained observation (Briggs 1990) that warps typically set in beyond this range of radii. We show that the inclusion of a dark matter halo in the calculation only marginally changes (by ~ 10 %) the radius for the onset of warps. For perturbations with higher azimu...

  9. Technical design of the PANDA disc DIRC detector

    Energy Technology Data Exchange (ETDEWEB)

    Etzelmueller, Erik; Biguenko, Klim; Dueren, Michael; Foehl, Klaus; Hayrapetyan, Avetik; Kroeck, Benno; Merle, Oliver; Rieke, Julian [Jusust-Liebig-Universitaet, Giessen (Germany); Collaboration: PANDA-Collaboration

    2014-07-01

    The physics program of the PANDA detector at the future FAIR facility at GSI requires excellent particle identification. In the forward angular region between 5 and 22 degrees, this will be achieved by a DISC DIRC detector that detects internally reflected Cherenkov light in order to separate pions, kaons and other hadrons. It will be the first time that a Disc-DIRC is used in a high performance 4π detector. Technical challenges such as radiation hardness of used materials and sensors, the presence of a strong magnetic field and limited space for mechanics which arise from constraints of the PANDA environment, had to be overcome in the detector design. The actual detector design and solutions to the formerly mentioned challenges are presented and discussed.

  10. Standing Rankine-Hugoniot Shocks in Black Hole Accretion Discs

    Institute of Scientific and Technical Information of China (English)

    GU Wei-Min; LU Ju-Fu

    2004-01-01

    @@ We study the problem of standing shocks in viscous disc-like accretion flows around black holes. For the first time we parametrize such a flow with two physical constants, namely the specific angular momentum accreted by the black hole j and the energy quantity K. By providing the global dependence of shock formation in the j - K parameter space, we show that a significant parameter region can ensure solutions with Rankine-Hugoniot shocks; and that the possibilities of shock formation are the largest for inviscid flows, decreasing with increasing viscosity, and ceasing to exist for a strong enough viscosity. Our results support the view that the standing shock is an essential ingredient in black hole accretion discs and is a general phenomenon in astrophysics, and that there should be a continuous change from the properties of inviscid flows to those of viscous ones.

  11. Impaired Compensation for Salt-Induced Urinary Calcium Loss in a Space Flight Model

    Science.gov (United States)

    Navidi, Meena; Harper, J. S.; Evans, J.; Fung, P.; Wolinsky, I.; Arnaud, S. B.; Wade, Charles E. (Technical Monitor)

    1994-01-01

    The loss of urinary calcium (UCa) induced by high sodium (HiNa) diets is compensated for by an increase in net intestinal Ca absorption (abs.). To determine the capacity of the intestine to absorb Ca in a space flight model in which the formation of 1,25-dihydroxyvitamin D (1,25-D) is suppressed, we induced Ca loss with HiNa diets (8%) and restricted dietary Ca (0.2%). In 200 g rats with hind limbs unloaded by tail suspension (S), we examined intestinal Ca abs. by direct measurement in the duodenum (everted gut sac or S/M), vitamin D receptors (VDR) and Ca balance. We also measured serum ionized calcium (ICa), pH, parathyroid hormone (PTH) and 1,25D. PTH was related to ICa (r = -0.44, p is less than 0.02), pH (r = -0.47, p is less than 0.02) and %Ca abs. (r = -0.40, p is less than 0.05). 1,25-D was related to %Ca abs. (r = 0.60, p is less than 0.001) but not VDR or S/M. Effects of the model were lower serum 1,25-D (110 +/- 59 vs. 199 +/- 80 pg/ml, p is less than 0.005), %Ca abs. (83 +/- 6.9 vs. 93 +/- 3.2, p is less than 0.03) and Ca balance (27 +/- 0.2 vs. 30 +/- 0.3 mg/d, p is less than 0.001) in S than controls (C). The HiNa diet increased UCa excretion from 2 to 13% of dietary Ca. Responses to HiNa diets, compared to normal Na, revealed no differences in 1,25-D, Ca abs. or VDR. Ca balances were lower in HiNa (27 +/- 0.3 vs. 30 +/- 0.4 mg/d, p is less than 0.001) in spite of higher Ca intakes. The failure of S rats fed HiNa diets to increase Ca abs. in response to Na-induced Ca loss appears to be related to suppressed 1,25-D in the space flight model, the cause of which remains obscure.

  12. Neurotoxicity of human neural cells induced by space radiation: in vitro risk assessment and countermeasure

    Science.gov (United States)

    Guida, P.; Vazquez, M.; Kim, A.

    As the duration of space missions increases the potential for neurological damage to astronauts resulting from exposure to radiation also increases To explore the cytotoxic effects of low and high LET radiation on cells of the central nervous system we utilized a model in vitro system consisting of a human neuronal progenitor cell line NT2 and its terminally differentiated derivative hNT neurons We found that exposure to numerous forms of ionizing radiation induced cell detachment necrosis and apoptosis in time dose and LET dependent manners From the slopes of the dose-response curves we calculated RBE values for each form of heavy ion radiation A sequential field of 1 GeV n protons and iron ions induced apoptosis to a greater extent than either ion alone and the time between hits was also an important determining factor In addition cycling neuronal progenitor cells underwent a dramatic G2 phase specific cell cycle delay within 6 hours following exposure to either low or high LET radiation The molecular effects of HZE radiation were also investigated with an emphasis on the cell stress response protein p53 Heavy ion radiation induced expression of p53 in a time and dose dependent manner in both neuronal progenitor and mature neuronal cells Furthermore several post-translational modifications to the p53 protein were detected 2 hours after exposure to gamma rays Experiments incorporating pifithrin- alpha a small molecule inhibitor of p53 suggest that induction of both apoptosis and the cell cycle delay in human NT2 cells is

  13. Evolution of linear warps in accretion discs and applications to protoplanetary discs in binaries

    CERN Document Server

    Foucart, Francois

    2014-01-01

    The existence of warped accretion discs is expected in a wide variety of astrophysical systems, including circumstellar discs in binaries and discs around binary protostars. A common feature of these discs is that they are perturbed by a misaligned external potential. In this paper, we study the long-term evolution of the disc warp and precession in the case of thick discs (with the dimensionless thickness $H/r$ larger than the viscosity parameter $\\alpha$) in which bending waves can propagate. For small warps, such discs undergo approximately rigid-body precession with a coherent global frequency. We derive the analytical expressions for the warp/twist profiles of the disc and the alignment timescale for a variety of disc models/parameters. Applying our results to circumbinary discs, we find that these discs align with the orbital plane of the binary on a timescale comparable to the global precession time of the disc, and typically much smaller than its viscous timescale. The development of parametric instab...

  14. Circumplanetary discs around young giant planets: a comparison between core-accretion and disc instability

    Science.gov (United States)

    Szulágyi, J.; Mayer, L.; Quinn, T.

    2017-01-01

    Circumplanetary discs can be found around forming giant planets, regardless of whether core accretion or gravitational instability built the planet. We carried out state-of-the-art hydrodynamical simulations of the circumplanetary discs for both formation scenarios, using as similar initial conditions as possible to unveil possible intrinsic differences in the circumplanetary disc mass and temperature between the two formation mechanisms. We found that the circumplanetary discs' mass linearly scales with the circumstellar disc mass. Therefore, in an equally massive protoplanetary disc, the circumplanetary discs formed in the disc instability model can be only a factor of 8 more massive than their core-accretion counterparts. On the other hand, the bulk circumplanetary disc temperature differs by more than an order of magnitude between the two cases. The subdiscs around planets formed by gravitational instability have a characteristic temperature below 100 K, while the core-accretion circumplanetary discs are hot, with temperatures even greater than 1000 K when embedded in massive, optically thick protoplanetary discs. We explain how this difference can be understood as the natural result of the different formation mechanisms. We argue that the different temperatures should persist up to the point when a full-fledged gas giant forms via disc instability; hence, our result provides a convenient criterion for observations to distinguish between the two main formation scenarios by measuring the bulk temperature in the planet vicinity.

  15. [Standardized terminology for disc disease].

    Science.gov (United States)

    Sánchez Pérez, M; Gil Sierra, A; Sánchez Martín, A; Gallego Gómez, P; Pereira Boo, D

    2012-01-01

    This article reviews the terminology used to describe morphological alterations in the intervertebral discs. Radiologists must be able to communicate information about the type, location, and severity of these alterations to medical and surgical clinicians. It is crucial to use simple, standard, and unified terminology to ensure comprehension not only among radiologists but also with professionals from the different specialties for whom the radiology reports are written (fundamentally traumatologists and neurosurgeons). This terminology will help ensure a more accurate diagnosis and better patient management.

  16. Proton and γ-ray Induced Radiation Effects on 1 Gbit LPDDR SDRAM Fabricated on Epitaxial Wafer for Space Applications

    Science.gov (United States)

    Park, Mi Young; Chae, Jang-Soo; Lee, Chol; Lee, Jungsu; Shin, Im Hyu; Kim, Ji Eun

    2016-09-01

    We present proton-induced single event effects (SEEs) and γ-ray-induced total ionizing dose (TID) data for 1 Gbit lowpower double data rate synchronous dynamic random access memory (LPDDR SDRAM) fabricated on a 5 μm epitaxial layer (54 nm complementary metal-oxide-semiconductor (CMOS) technology). We compare our radiation tolerance data for LPDDR SDRAM with those of general DDR SDRAM. The data confirms that our devices under test (DUTs) are potential candidates for space flight applications.

  17. Artificial Cervical Disc Arthroplasty (ACDA): tips and tricks

    Science.gov (United States)

    Khadivi, Masoud; Rahimi Movaghar, Vafa; Abdollahzade, Sina

    2012-01-01

    presented with cervical discopathy who had myelopathy or radiculopathy and failed conservative management, undergoing cervical disc arthroplasty by ACDA were included, consecutively. Patients were followed for at least 2 years. Exclusion criteria was age greater than 60 years, non compliance with the study protocol, osteoporosis, infection, congenital or post traumatic deformity, malignancy metabolic bone disease, and narrow cervical canal (less than 12 mm). Heterotopic ossification and adjacent segment degenerative changes were assessed at 2 years follow up by means of neutral and dynamic xrays and CT/MRI if clinically indicated. Neck and upper extremity pain were assessed before the procedure and in the first post-operative visit and 3 months later by means of visual analogue scale. A standard approach was performed to the anterior cervical spine. Patients were positioned supine while holding neck in neutral position. A combination of sharp and blunt dissection was performed to expose longus coli musculature and anterior cervical vertebrae. Trachea and esophagus were retracted medially and carotid artery and jugular vein laterally. After a thorough discectomy, the intersomatic space is distracted in a parallel way by a vertebral distracter. Followed by Caspar distractor is applied to provide a working channel into posterior disc space. In this stage, any remnant disc materials as well as osteophytes are removed and foraminal decompression is done. Posterior longitudinal ligament (PLL) opening and removal, although discouraged by some, is done next. In order to define the size of the prosthesis, multiple trials are tested. It is important not to exceed the height of the healthy adjacent disc to avoid facet joint overdistraction. An specific insertor is applied to plant the prosthesis in disc space. Control X-rays are advised to check the precise positioning of the implant. Results: one hundred-fifty three patients including 87 females and 66 males were included. The mean

  18. Minimum weight design of inhomogeneous rotating discs

    Energy Technology Data Exchange (ETDEWEB)

    Jahed, Hamid [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of); Farshi, Behrooz [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of)]. E-mail: farshi@iust.ac.ir; Bidabadi, Jalal [Department of Mechanical Engineering, Iran University of Science and Technology, Tehran 16844 (Iran, Islamic Republic of)

    2005-01-01

    There are numerous applications for gas turbine discs in the aerospace industry such as in turbojet engines. These discs normally work under high temperatures while subjected to high angular velocities. Minimizing the weight of such items in aerospace applications results in benefits such as low dead weights and lower costs. High speed of rotation causes large centrifugal forces in a disc and simultaneous application of high temperatures reduces disc material strength. Thus, the latter effects tend to increase deformations of the disc under the applied loads. In order to obtain a reliable disc analysis and arrive at the corresponding correct stress distribution, solutions should consider changes in material properties due to the temperature field throughout the disc. To achieve this goal, an inhomogeneous disc model with variable thickness is considered. Using the variable material properties method, stresses are obtained for the disc under rotation and a steady temperature field. In this paper this is done by modelling the rotating disc as a series of rings of different but constant properties. The optimum disc profile is arrived at by sequentially proportioning the thicknesses of each ring to satisfy the stress requirements. This method vis-a-vis a mathematical programming procedure for optimization shows several advantages. Firstly, it is simple iterative proportioning in each design cycle not requiring involved mathematical operations. Secondly, due to its simplicity it alleviates the necessity of certain simplifications that are common in so-called rigorous mathematical procedures. The results obtained, compared to those published in the literature show agreement and superiority. A further advantage of the proposed method is the independence of the end results from the initially assumed point in the iterative design routine, unlike most methods published so far.

  19. Cell Therapy Using Bone Marrow-Derived Stem Cell Overexpressing BMP-7 for Degenerative Discs in a Rat Tail Disc Model.

    Science.gov (United States)

    Liao, Jen-Chung

    2016-01-01

    Degenerative discs can cause low back pain. Cell-based transplantation or growth factors therapy have been suggested as a strategy to stimulate disc regeneration. Bone marrow-derived mesenchymal stem cells (BMDMSC) containing bone morphogenetic protein-7 (BMP-7) gene were constructed. We evaluated the effectiveness of these BMP-7 overexpressing cells on degenerative discs in rat tails. In vitro and in vivo studies were designed. In the first stage, the rats were divided into two group according to discs punctured by different needle gauges (18 gauge and 22 gauge). In the second stage, the ideal size of needle was used to induce rat tail disc degeneration. These animals are divided into three groups according to timing of treatment (zero-week, two-week, four-week). Each group was divided into three treating subgroups: control group, BMDMSC group, and Baculo-BMP-7-BMDMSC group. Each rat undergoes radiography examination every two weeks. After eight weeks, the discs were histologically examined with hematoxylin and eosin stain and Alcian blue stain. The 18-gauge group exhibited significant decrease in disc height index (%) than 22-gauge group at eight weeks at both Co6-7 (58.1% ± 2.8% vs. 63.7% ± 1.0%, p = 0.020) and Co8-9 discs (62.7% ± 2.8% vs. 62.8% ± 1.5%, p = 0.010). Baculo-BMP-7-BMDMSCs group showed significant difference in disc height index compared to the BMDMSCs group at both Co6-7 (93.7% ± 1.5% vs. 84.8% ± 1.0%, p = 0.011) and Co8-9 (86.0% ± 2.1% vs. 81.8% ± 1.7%, p = 0.012). In Baculo-BMP-7-BMDMSCs group, the zero-week treatment subgroup showed significant better in disc height index compared to two-week treatment group (p = 0.044), and four-week treatment group (p = 0.011). The zero-week treatment subgroup in Baculo-BMP-7-BMDMSCs group also had significant lower histology score than two-week treatment (4.3 vs. 5.7, p = 0.045) and four-week treatment (4.3 vs. 6.0, p = 0.031). In conclusion, Baculo-BMP-7-BMDMSC can slow down the progression of disc

  20. Methodology for optic disc localization

    Directory of Open Access Journals (Sweden)

    Marcos A. Leiva-Vasconcellos

    2014-04-01

    Full Text Available The use of digital images in many areas of society is an activity that has reached a remarkable growth in recent years mainly due to the great development that has occurred in technology around the world. These images have a great use in many branches of medicine because they facilitate the diagnosis by specialists and thus help patients to be diagnosed long before symptoms of the disease begin to manifest. For Ophthalmology, one of the most used images are the digital retinography, If it is used properly will allow the occurrence of eye diseases such as glaucoma and diabetic retinopathy. One of the main elements shown on retinal images are the optic disc, the location and detection is of vital importance for working with different parts of the structure o f the eye. This paper proposes two techniques for locating the optic disc in retinal images based on the combination of multiple filters and applying logical operators. To test the algorithms diaretDB0v11 and DRIVE database were used , as a result of the tests are correctly located the 99.091 % of the images from both repo sitories, and were successfully detected 85 % and 87.143 % of images of DRIVE database and diaretDB0v11 respectively.

  1. DISC1 (disrupted-in-schizophrenia-1 regulates differentiation of oligodendrocytes.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Hattori

    Full Text Available Disrupted-in-schizophrenia 1 (DISC1 is a gene disrupted by a translocation, t(1;11 (q42.1;q14.3, that segregates with major psychiatric disorders, including schizophrenia, recurrent major depression and bipolar affective disorder, in a Scottish family. Here we report that mammalian DISC1 endogenously expressed in oligodendroglial lineage cells negatively regulates differentiation of oligodendrocyte precursor cells into oligodendrocytes. DISC1 expression was detected in oligodendrocytes of the mouse corpus callosum at P14 and P70. DISC1 mRNA was expressed in primary cultured rat cortical oligodendrocyte precursor cells and decreased when oligodendrocyte precursor cells were induced to differentiate by PDGF deprivation. Immunocytochemical analysis showed that overexpressed DISC1 was localized in the cell bodies and processes of oligodendrocyte precursor cells and oligodendrocytes. We show that expression of the myelin related markers, CNPase and MBP, as well as the number of cells with a matured oligodendrocyte morphology, were decreased following full length DISC1 overexpression. Conversely, both expression of CNPase and the number of oligodendrocytes with a mature morphology were increased following knockdown of endogenous DISC1 by RNA interference. Overexpression of a truncated form of DISC1 also resulted in an increase in expression of myelin related proteins and the number of mature oligodendrocytes, potentially acting via a dominant negative mechanism. We also identified involvement of Sox10 and Nkx2.2 in the DISC1 regulatory pathway of oligodendrocyte differentiation, both well-known transcription factors involved in the regulation of myelin genes.

  2. Magnetic resonance imaging of lumbar intervertebral discs in elderly patients with minor trauma

    Energy Technology Data Exchange (ETDEWEB)

    Afzal, Suhail [Orthopaedic Spine Surgeon, Spine Clinic, Srinagar, Kashmir (India)], E-mail: drsuhaila@yahoo.com; Akbar, Saleem [Nehru Hospital, Rose Belle (Mauritius)

    2009-05-15

    Purpose: Vertebral body fractures due to minor trauma, which commonly occur in the elderly, are a frequently encountered clinical problem. We utilized MRI in patients with acute back pain following minor injury to ensure the earliest possible diagnosis. Lumbar discs adjacent to fractured vertebral bodies were evaluated, using magnetic resonance imaging (MRI), to elucidate how often these discs were injured and how the injured discs were depicted by MRI. Materials and methods: We retrospectively reviewed MR images of 74 discs from 37 elderly patients (>65-year-old) with a single level vertebral fracture (fracture group). Patients with multiple-level fractures, burst fractures and/or major trauma, such as that resulting from a traffic accident, were excluded from this study. We also reviewed MR images of 190 discs from 27 elderly patients diagnosed with lumbar stenosis, who had no previous history of vertebral body fractures (stenosis group). Results: In the fracture group, 23% (17/74) of T1-weighted images exhibited a high-intensity area in the disc, whereas only 3% (5/190) exhibited a high-intensity area in the stenosis group. In some cases, in the T2-weighted images we also found a high-intensity zone in discs that showed low- or iso-intensity. This phenomenon was more frequently observed in the fracture group (47%: 35/74) than in the stenosis group. Conclusion: The present study indicates that, in elderly patients, intervertebral discs adjacent to vertebral fractures resulting from minor trauma are often injured. Because hemorrhage is the most likely cause of a high-intensity T1-weighted image, the results indicate that hemorrhage can be induced in a disc adjacent to a vertebral body fractured by even minor trauma.

  3. Irradiation-induced degradation of amorphous silicon solar cells in space

    NARCIS (Netherlands)

    Klaver, A.

    2007-01-01

    Solar cells are the prime power supply for satellites in space. Space is, however, a hostile environment for electronic devices, such as solar cells: in space the devices are subjected to large temperature cycles, atomic oxygen, space dust, meteorites, and high-energy charged-particle irradiation. I

  4. Irradiation-induced degradation of amorphous silicon solar cells in space

    NARCIS (Netherlands)

    Klaver, A.

    2007-01-01

    Solar cells are the prime power supply for satellites in space. Space is, however, a hostile environment for electronic devices, such as solar cells: in space the devices are subjected to large temperature cycles, atomic oxygen, space dust, meteorites, and high-energy charged-particle irradiation. I

  5. A Simulation Model of Focus and Radial Servos in Compact Disc Players with Disc Surface Defects

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Andersen, Palle

    2004-01-01

    Compact Disc players have been on the market in more than two decades.As a consequence most of the control servo problems have been solved. A large remaining problem to solve is the handling of Compact Discs with severe surface defects like scratches and fingerprints. This paper introduces a method...... for making the design of controllers handling surface defects easier. A simulation model of Compact Disc players playing discs with surface defects is presented. The main novel element in the model is a model of the surface defects. That model is based on data from discs with surface defects. This model...

  6. Thin viscoelastic disc subjected to radial non-stationary loading

    Directory of Open Access Journals (Sweden)

    Adámek V.

    2010-07-01

    Full Text Available The investigation of non-stationary wave phenomena in isotropic viscoelastic solids using analytical approaches is the aim of this paper. Concretely, the problem of a thin homogeneous disc subjected to radial pressure load nonzero on the part of its rim is solved. The external excitation is described by the Heaviside function in time, so the nonstationary state of stress is induced in the disc. Dissipative material behaviour of solid studied is represented by the discrete material model of standard linear viscoelastic solid in the Zener configuration. After the derivation of motion equations final form, the method of integral transforms in combination with the Fourier method is used for finding the problem solution. The solving process results in the derivation of integral transforms of radial and circumferential displacement components. Finally, the type of derived functions singularities and possible methods for their inverse Laplace transform are mentioned.

  7. In Vitro Studies on Space Radiation-Induced Delayed Genetic Responses: Shielding Effects

    Science.gov (United States)

    Kadhim, Munira A.; Green, Lora M.; Gridley, Daila S.; Murray, Deborah K.; Tran, Da Thao; Andres, Melba; Pocock, Debbie; Macdonald, Denise; Goodhead, Dudley T.; Moyers, Michael F.

    2003-01-01

    Understanding the radiation risks involved in spaceflight is of considerable importance, especially with the long-term occupation of ISS and the planned crewed exploration missions. Several independent causes may contribute to the overall risk to astronauts exposed to the complex space environment, such as exposure to GCR as well as SPES. Protons and high-Z energetic particles comprise the GCR spectrum and may exert considerable biological effects even at low fluence. There are also considerable uncertainties associated with secondary particle effects (e.g. HZE fragments, neutrons etc.). The interaction of protons and high-LET particles with biological materials at all levels of biological organization needs to be investigated fully in order to establish a scientific basis for risk assessment. The results of these types of investigation will foster the development of appropriately directed countermeasures. In this study, we compared the biological responses to proton irradiation presented to the target cells as a monoenergetic beam of particles of complex composition delivered to cells outside or inside a tissue phantom head placed in the United States EVA space suit helmet. Measurements of chromosome aberrations, apoptosis, and the induction of key proteins were made in bone marrow from CBA/CaJ and C57BL/6 mice at early and late times post exposure to radiation at 0, 0.5, 1 and 2 Gy while inside or outside of the helmet. The data showed that proton irradiation induced transmissible chromosomal/genomic instability in haematopoietic stem cells in both strains of mice under both irradiation conditions and especially at low doses. Although differences were noted between the mouse strains in the degree and kinetics of transforming growth factor-beta 1 and tumor necrosis factor-alpha secretion, there were no significant differences observed in the level of the induced instability under either radiation condition, or for both strains of mice. Consequently, when

  8. Post-Main Sequence Evolution of Debris Discs

    OpenAIRE

    Bonsor, Amy; Wyatt, Mark

    2010-01-01

    The population of debris discs on the main sequence is well constrained, however very little is known about debris discs around evolved stars. In this work we provide a theoretical framework that considers the effects of stellar evolution on debris discs; firstly considering the evolution of an individual disc from the main sequence through to the white dwarf phase, then extending this to the known population of debris discs around main sequence A stars. It is found that discs around evolved ...

  9. Thin, thick and dark discs in LCDM

    CERN Document Server

    Read, J I; Agertz, O; Debattista, Victor P

    2008-01-01

    In a LCDM cosmology, the Milky Way accretes satellites into the stellar disc. We use cosmological simulations to assess the frequency of near disc plane and higher inclination accretion events, and collisionless simulations of satellite mergers to quantify the final state of the accreted material and the effect on the thin disc. On average, a Milky Way-sized galaxy has 1.5 subhalos with vmax>80km/s; 5 with vmax>60km/s; and 13 with vmax>40km/s merge at redshift z>1. A third of these merge at an impact angle 20 degrees) are twice as likely as low inclination ones. These lead to structures that closely resemble the recently discovered inner/outer stellar halos. They also do more damage to the Milky Way stellar disc creating a more pronounced flare, and warp; both long-lived and consistent with current observations. The most massive mergers (vmax > 80km/s) heat t he thin disc enough to produce a thick disc. These heated thin disc stars are essential for obtaining a thick disc as massive as that seen in the Milky ...

  10. Hygroviscoelasticity of the Human Intervertebral Disc.

    Science.gov (United States)

    1980-07-01

    hernia - tion with age depends on the biochemical changes that occur in the material of the disc during its maturation process. However, a careful machanics...EFFORT One of the recurring pieces of information required in disc response is the intra- discal pressure when the spine is loaded axially. This

  11. Hydromagnetic Flow between Two Rotating Coaxial Discs

    Directory of Open Access Journals (Sweden)

    Abdul Aleem Khan

    1970-01-01

    Full Text Available This paper relates to the steady flow of an electrically incompressible viscous fluid between two parallel coaxial rotating discs with a transverse magnetic field when the discs are rotating in the same direction with the same velocity and there is a source at the centre.

  12. Genetic association studies in lumbar disc degeneration

    DEFF Research Database (Denmark)

    Eskola, Pasi J; Lemmelä, Susanna; Kjaer, Per

    2012-01-01

    Low back pain is associated with lumbar disc degeneration, which is mainly due to genetic predisposition. The objective of this study was to perform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magnetic resonance imaging (MRI) in humans....

  13. Requirements for an artificial intervertebral disc

    NARCIS (Netherlands)

    Eijkelkamp, MF; van Donkelaar, CC; Veldhuizen, AG; van Horn, [No Value; Huyghe, JM; Verkerke, GJ

    Intervertebral disc degeneration is an important social and economic problem. Presently available artificial intervertebral discs (AIDs) are insufficient and the main surgical intervention is still spinal fusion. The objective of the present study is to present a list of requirements for the

  14. Feature Based Control of Compact Disc Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh

    Two servo control loops are used to keep the Optical Pick-up Unit focused and radially on the information track of the Compact Disc. These control servos have problems handling surface faults on the Compact Disc. In this Ph.D thesis a method is proposed to improve the handling of these surface...

  15. The inner cavity of the circumnuclear disc

    Science.gov (United States)

    Blank, M.; Morris, M. R.; Frank, A.; Carroll-Nellenback, J. J.; Duschl, W. J.

    2016-06-01

    The circumnuclear disc (CND) orbiting the Galaxy's central black hole is a reservoir of material that can ultimately provide energy through accretion, or form stars in the presence of the black hole, as evidenced by the stellar cluster that is presently located at the CND's centre. In this paper, we report the results of a computational study of the dynamics of the CND. The results lead us to question two paradigms that are prevalent in previous research on the Galactic Centre. The first is that the disc's inner cavity is maintained by the interaction of the central stellar cluster's strong winds with the disc's inner rim, and secondly, that the presence of unstable clumps in the disc implies that the CND is a transient feature. Our simulations show that, in the absence of a magnetic field, the interaction of the wind with the inner disc rim actually leads to a filling of the inner cavity within a few orbital time-scales, contrary to previous expectations. However, including the effects of magnetic fields stabilizes the inner disc rim against rapid inward migration. Furthermore, this interaction causes instabilities that continuously create clumps that are individually unstable against tidal shearing. Thus the occurrence of such unstable clumps does not necessarily mean that the disc is itself a transient phenomenon. The next steps in this investigation are to explore the effect of the magnetorotational instability on the disc evolution and to test whether the results presented here persist for longer time-scales than those considered here.

  16. The maximum rotation of a galactic disc

    NARCIS (Netherlands)

    Bottema, R

    1997-01-01

    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously

  17. Light-induced space-charge fields for the structuration of dielectric materials; Lichtinduzierte Raumladungsfelder zur Strukturierung dielektrischer Materialien

    Energy Technology Data Exchange (ETDEWEB)

    Eggert, H.A.

    2006-11-15

    Light-induced space-charge fields in lithium-niobate crystals are used for patterning of dielectric materials. This includes tailored ferroelectric domains in the bulk of the crystal, different sorts of micro and nanoparticles on a crystal surface, as well as poling of electrooptic chromophores. A stochastical model is introduced, which can describe the spatial inhomogeneous domain inversion. (orig.)

  18. K-space and image-space combination for motion-induced phase-error correction in self-navigated multicoil multishot DWI.

    Science.gov (United States)

    Van, Anh T; Karampinos, Dimitrios C; Georgiadis, John G; Sutton, Bradley P

    2009-11-01

    Motion during diffusion encodings leads to different phase errors in different shots of multishot diffusion-weighted acquisitions. Phase error incoherence among shots results in undesired signal cancellation when data from all shots are combined. Motion-induced phase error correction for multishot diffusion-weighted imaging (DWI) has been studied extensively and there exist multiple phase error correction algorithms. A commonly used correction method is the direct phase subtraction (DPS). DPS, however, can suffer from incomplete phase error correction due to the aliasing of the phase errors in the high spatial resolution phases. Furthermore, improper sampling density compensation is also a possible issue of DPS. Recently, motion-induced phase error correction was incorporated in the conjugate gradient (CG) image reconstruction procedure to get a nonlinear phase correction method that is also applicable to parallel DWI. Although the CG method overcomes the issues of DPS, its computational requirement is high. Further, CG restricts to sensitivity encoding (SENSE) for parallel reconstruction. In this paper, a new time-efficient and flexible k-space and image-space combination (KICT) algorithm for rigid body motion-induced phase error correction is introduced. KICT estimates the motion-induced phase errors in image space using the self-navigated capability of the variable density spiral trajectory. The correction is then performed in k -space. The algorithm is shown to overcome the problem of aliased phase errors. Further, the algorithm preserves the phase of the imaging object and receiver coils in the corrected k -space data, which is important for parallel imaging applications. After phase error correction, any parallel reconstruction method can be used. The KICT algorithm is tested with both simulated and in vivo data with both multishot single-coil and multishot multicoil acquisitions. We show that KICT correction results in diffusion-weighted images with higher

  19. On the reliability of protostellar disc mass measurements and the existence of fragmenting discs

    CERN Document Server

    Dunham, Michael M; Arce, Héctor G

    2014-01-01

    We couple non-magnetic, hydrodynamical simulations of collapsing protostellar cores with radiative transfer evolutionary models to generate synthetic observations. We then use these synthetic observations to investigate the extent to which a simple method for measuring protostellar disc masses used in the literature recovers the intrinsic masses of the discs formed in the simulations. We evaluate the effects of contamination from the surrounding core, partially resolving out the disc, optical depth, fixed assumed dust temperatures, inclination, and the dust opacity law. We show that the combination of these effects can lead to disc mass underestimates by up to factors of 2-3 at millimeter wavelengths and up to an order of magnitude or larger at submillimeter wavelengths. The optically thin portions of protostellar discs are generally cooler in the Class I stage than the Class 0 stage since Class I discs are typically larger and more optically thick, and thus more shielded. The observed disc mass distribution ...

  20. Twisted accretion discs: Pt. 4. Alignment in polytropic discs and low. cap alpha. limit

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S.

    1988-07-01

    Twisted thin accretion discs are of interest in explaining long-term periodicities in X-ray binaries, the eclipse in Epsilon Aurigae, and perhaps precessing radio jets and possible warped molecular outflows in star-forming regions. Earlier results used isothermal discs to determine the alignment radius, Rsub(a). Now we see how polytropic discs effect earlier results for discs around compact objects and around close binaries. We find that Rsub(a) for polytropic discs can be up to an order of magnitude larger, depending on the polytropic index, the viscosity parameter and the precession mechanism. There is little change in the earlier conclusion that the case for alignment in Her X-1 is marginal, while there is substantial alignment in epsilon Aur. A lower limit is put on ..cap alpha.. for isothermal discs, which is expected to hold for polytropic discs as well. A bound is put on the energy of the perturbed flows.

  1. The formation of planets by disc fragmentation

    Directory of Open Access Journals (Sweden)

    Stamatellos Dimitris

    2013-04-01

    Full Text Available I discuss the role that disc fragmentation plays in the formation of gas giant and terrestrial planets, and how this relates to the formation of brown dwarfs and low-mass stars, and ultimately to the process of star formation. Protostellar discs may fragment, if they are massive enough and can cool fast enough, but most of the objects that form by fragmentation are brown dwarfs. It may be possible that planets also form, if the mass growth of a proto-fragment is stopped (e.g. if this fragment is ejected from the disc, or suppressed and even reversed (e.g by tidal stripping. I will discuss if it is possible to distinguish whether a planet has formed by disc fragmentation or core accretion, and mention of a few examples of observed exoplanets that are suggestive of formation by disc fragmentation.

  2. Strongly magnetized accretion discs require poloidal flux

    Science.gov (United States)

    Salvesen, Greg; Armitage, Philip J.; Simon, Jacob B.; Begelman, Mitchell C.

    2016-08-01

    Motivated by indirect observational evidence for strongly magnetized accretion discs around black holes, and the novel theoretical properties of such solutions, we investigate how a strong magnetization state can develop and persist. To this end, we perform local simulations of accretion discs with an initially purely toroidal magnetic field of equipartition strength. We demonstrate that discs with zero net vertical magnetic flux and realistic boundary conditions cannot sustain a strong toroidal field. However, a magnetic pressure-dominated disc can form from an initial configuration with a sufficient amount of net vertical flux and realistic boundary conditions. Our results suggest that poloidal flux is a necessary prerequisite for the sustainability of strongly magnetized accretion discs.

  3. Strongly magnetized accretion discs require poloidal flux

    CERN Document Server

    Salvesen, Greg; Simon, Jacob B; Begelman, Mitchell C

    2016-01-01

    Motivated by indirect observational evidence for strongly magnetized accretion discs around black holes, and the novel theoretical properties of such solutions, we investigate how a strong magnetization state can develop and persist. To this end, we perform local simulations of accretion discs with an initially purely toroidal magnetic field of equipartition strength. We demonstrate that discs with zero net vertical magnetic flux and realistic boundary conditions cannot sustain a strong toroidal field. However, a magnetic pressure-dominated disc can form from an initial configuration with a sufficient amount of net vertical flux and realistic boundary conditions. Our results suggest that poloidal flux is a necessary prerequisite for the sustainability of strongly magnetized accretion discs.

  4. Magnetic resonance imaging of intervertebral disc degeneration

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Hiroshi; Noguchi, Masao (Kitakyushu City Yahata Hospital, Fukuoka (Japan)); Kira, Hideaki; Fujiki, Hiroshi; Shimokawa, Isao; Hinoue, Kaichi

    1993-02-01

    The aim of this study was to correlate the degree of lumbar intervertebral disc degeneration with findings of magnetic resonance imaging (MRI). Seventeen autopsied (from 7 patients) and 21 surgical (from 20 patients) intervertebral discs were used as specimens for histopathological examination. In addition, 21 intervertebral discs were examined on T2-weighted images. Histopathological findings from both autopsied and surgical specimens were well correlated with MRI findings. In particular, T2-weighted images reflected increased collagen fibers and rupture within the fibrous ring accurately. However, when severely degenerated intervertebral discs and hernia protruding the posterior longitudinal ligament existed, histological findings were not concordant well with T2-weighted images. Morphological appearances of autopsy specimens, divided into four on T2-weighted images, were well consistent with histological degeneration. This morphological classification, as shown on T2-weighted images, could also be used in the evaluation of intervertebral disc degeneration. (N.K.).

  5. Lumbar Epidural Varix Mimicking Disc Herniation.

    Science.gov (United States)

    Bursalı, Adem; Akyoldas, Goktug; Guvenal, Ahmet Burak; Yaman, Onur

    2016-07-01

    Lumbar radiculopathy is generally caused by such well-recognized entity as lumbar disc herniation in neurosurgical practice; however rare pathologies such as thrombosed epidural varix may mimic them by causing radicular symptoms. In this case report, we present a 26-year-old man with the complaint of back and right leg pain who was operated for right L4-5 disc herniation. The lesion interpreted as an extruded disc herniation preoperatively was found to be a thrombosed epidural varix compressing the nerve root preoperatively. The nerve root was decompressed by shrinking the lesion with bipolar thermocoagulation and excision. The patient's complaints disappeared in the postoperative period. Thrombosed lumbar epidural varices may mimic lumbar disc herniations both radiologically and clinically. Therefore, must be kept in mind in the differential diagnosis of lumbar disc herniations. Microsurgical techniques are mandatory for the treatment of these pathologies and decompression with thermocoagulation and excision is an efficient method.

  6. The Development of Countermeasures for Space Radiation Induced Adverse Health Effects

    Science.gov (United States)

    Kennedy, Ann

    The Development of Countermeasures for Space Radiation Induced Adverse Health Effects Ann R. Kennedy Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, United States 19104-6072 The development of countermeasures for radiation induced adverse health effects is a lengthy process, particularly when the countermeasure/drug has not yet been evaluated in human trials. One example of a drug developed from the bench to the clinic is the soybean-derived Bowman-Birk inhibitor (BBI), which has been developed as a countermeasure for radiation induced cancer. It was originally identified as a compound/drug that could prevent the radiation induced carcinogenic process in an in vitro assay system in 1975. The first observation that BBI could inhibit carcinogenesis in animals was in 1985. BBI received Investigational New Drug (IND) Status with the U.S. Food and Drug Administration (FDA) in 1992 (after several years of negotiation with the FDA about the potential IND status of the drug), and human trials began at that time. Phase I, II and III human trials utilizing BBI have been performed under several INDs with the FDA, and an ongoing Phase III trial will be ending in the very near future. Thus, the drug has been in development for 35 years at this point, and it is still not a prescription drug on the market which is available for human use. A somewhat less time-consuming process is to evaluate compounds that are on the GRAS (Generally Recognized as Safe) list. These compounds would include some over-the-counter medications, such as antioxidant vitamins utilized in human trials at the levels for which Recommended Dietary Allowances (RDAs) have been established. To determine whether GRAS substances are able to have beneficial effects on radiation induced adverse health effects, it is still likely to be a lengthy process involving many years to potentially decades of human trial work. The

  7. Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations

    Directory of Open Access Journals (Sweden)

    Mohammad eNikkhoo

    2015-01-01

    Full Text Available The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disc degeneration results in degradation of disc solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid-fluid interactions of degenerative discs to cyclic loadings are not well studied yet. The fluid-solid interactions in discs can be evaluated by mathematical models, especially the poroelastic finite element models. We developed a robust disc poroelastic FE model to analyze the effect of degeneration on solid-fluid interactions within disc subjected to cyclic loadings at different loading frequencies. A backward analysis combined with in-vitro experiments were used to find the elastic modulus and hydraulic permeability of intact and enzyme-induced degenerated porcine discs. The results showed that the averaged peak-to-peak disc deformations during the in-vitro cyclic tests were well fitted with limited FE simulations and a quadratic response surface regression for both disc groups. The results showed that higher loading frequency increased the intradiscal pressure, decreased the total fluid loss, and slightly increased the maximum axial stress within solid matrix. Enzyme-induced degeneration decreased the intradiscal pressure and total fluid loss, and barely changed the maximum axial stress within solid matrix. The increase of intradiscal pressure and total fluid loss with loading frequency was less sensitive after the frequency elevated to 0.1 Hz for the enzyme-induced degenerated disc. Based on this study, it is found that enzyme-induced degeneration decreases energy attenuation capability of disc, but less change the strength of disc.

  8. Mathematical Interpretation between Genotype and Phenotype Spaces and Induced Geometric Crossovers

    CERN Document Server

    Yoon, Yourim; Moraglio, Alberto; Moon, Byung-Ro

    2009-01-01

    In this paper, we present that genotype-phenotype mapping can be theoretically interpreted using the concept of quotient space in mathematics. Quotient space can be considered as mathematically-defined phenotype space in the evolutionary computation theory. The quotient geometric crossover has the effect of reducing the search space actually searched by geometric crossover, and it introduces problem knowledge in the search by using a distance better tailored to the specific solution interpretation. Quotient geometric crossovers are directly applied to the genotype space but they have the effect of the crossovers performed on phenotype space. We give many example applications of the quotient geometric crossover.

  9. Gas in the protoplanetary disc of HD 169142: Herschel's view

    CERN Document Server

    Meeus, G; Woitke, P; Montesinos, B; Mendigutía, I; Riviere-Marichalar, P; Eiroa, C; Mathews, G S; Vandenbussche, B; Howard, C D; Roberge, A; Sandell, G; Duchêne, G; Ménard, F; Grady, C A; Dent, W R F; Kamp, I; Augereau, J C; Thi, W F; Tilling, I; Alacid, J M; Andrews, S; Ardila, D R; Aresu, G; Barrado, D; Brittain, S; Ciardi, D R; Danchi, W; Fedele, D; de Gregorio-Monsalvo, I; Heras, A; Huelamo, N; Krivov, A; Lebreton, J; Liseau, R; Martin-Zaidi, C; Mora, A; Morales-Calderon, M; Nomura, H; Pantin, E; Pascucci, I; Phillips, N; Podio, L; Poelman, D R; Ramsay, S; Riaz, B; Rice, K; Solano, E; Walker, H; White, G J; Williams, J P; Wright, G

    2010-01-01

    In an effort to simultaneously study the gas and dust components of the disc surrounding the young Herbig Ae star HD 169142, we present far-IR observations obtained with the PACS instrument onboard the Herschel Space Observatory. This work is part of the Open Time Key Project GASPS, which is aimed at studying the evolution of protoplanetary discs. To constrain the gas properties in the outer disc, we observed the star at several key gas-lines, including [OI] 63.2 and 145.5 micron, [CII] 157.7 micron, CO 72.8 and 90.2 micron, and o-H2O 78.7 and 179.5 micron. We only detect the [OI] 63.2 micron line in our spectra, and derive upper limits for the other lines. We complement our data set with PACS photometry and 12/13CO data obtained with the Submillimeter Array. Furthermore, we derive accurate stellar parameters from optical spectra and UV to mm photometry. We model the dust continuum with the 3D radiative transfer code MCFOST and use this model as an input to analyse the gas lines with the thermo-chemical code ...

  10. SOAR observations of the high-viscosity accretion disc of the dwarf nova V4140 Sagitarii in quiescence and in outburst

    Science.gov (United States)

    Baptista, Raymundo; Borges, Bernardo W.; Oliveira, Alexandre S.

    2016-12-01

    We report the analysis of 22 B-band light curves of the dwarf nova V4140 Sgr obtained with SOAR Optical Imager (SOI)/SOAR during two nights along the decline of a superoutburst in 2006 September 12-24 and in quiescence over 50 d following the superoutburst. 3D eclipse mapping of the outburst light curves indicates that the accretion disc is elliptical (eccentricity e = 0.13) and that superhump maximum occurs when the mass donor star is aligned with the bulge of the elliptical disc. The accretion disc is geometrically thin both in outburst and in quiescence; it fills the primary Roche lobe in the outburst and shrinks to about half this size in quiescence. The stability of the eclipse shape, width and depth along quiescence and the derived disc surface brightness distribution indicate that the quiescent accretion disc is in a high-viscosity, steady-state. Flickering mapping of the quiescent data reveals that the low-frequency flickering arises from an azimuthally extended stream-disc impact region at disc rim and from the innermost disc region, whereas the high-frequency flickering originates in the accretion disc. Assuming the disc-related flickering to be caused by fluctuations in the energy dissipation rate induced by magnetohydrodynamic turbulence (Geertsema & Achterberg), we find that the quiescent disc viscosity parameter is large, α ≃ 0.2-0.4, at all radii. The high-viscosity quiescent disc and the inferred low disc temperatures in superoutburst are inconsistent with expectations of the disc-instability model, and lead to the conclusion that the outbursts of V4140 Sgr are powered by mass transfer bursts from its donor star.

  11. Continuum and line modelling of discs around young stars. II. Line diagnostics for GASPS from the DENT grid

    Science.gov (United States)

    Kamp, I.; Woitke, P.; Pinte, C.; Tilling, I.; Thi, W.-F.; Menard, F.; Duchene, G.; Augereau, J.-C.

    2011-08-01

    Aims: We want to understand the chemistry and physics of discs on the basis of a large unbiased and statistically relevant grid of disc models. One of the main goals is to explore the diagnostic power of various gas emission lines and line ratios for deriving main disc parameters such as the gas mass. Methods: We explored the results of the DENT grid (Disk Evolution with Neat Theory) that consists of 300 000 disc models with 11 free parameters. Through a statistical analysis, we searched for correlations and trends in an effort to find tools for disc diagnostic. Results: All calculated quantities like species masses, temperatures, continuum, and line fluxes differ by several orders of magnitude across the entire parameter space. The broad distribution of these quantities as a function of input parameters shows the limitation of using a prototype T Tauri or Herbig Ae/Be disc model. The statistical analysis of the DENT grid shows that CO gas is rarely the dominant carbon reservoir in discs. Models with large inner radii (10 times the dust condensation radius) and/or shallow surface density gradients lack massive gas-phase water reservoirs. Also, 60% of the discs have gas temperatures averaged over the oxygen mass in the range between 15 and 70 K; the average gas temperatures for CO and O differ by less than a factor two. Our study of the observational diagnostics shows that the [C ii] 158 μm fine structure line flux is very sensitive to the stellar UV flux and presence of a UV excess, and that it traces the outer disc radius (Rout). In the submm, the CO low J rotational lines also trace Rout. Low [O i] 63/145 line ratios (disc models without UV excess. A combination of the [O i] 63 line and low J CO lines correlates with several disc properties, such as the average O i gas temperature in

  12. Numerical search for a potential planet sculpting the young disc of HD 115600

    CERN Document Server

    Thilliez, E

    2016-01-01

    Radial and azimuthal features (such as disc offsets and eccentric rings) seen in high resolution images of debris discs, provide us with the unique opportunity of finding potential planetary companions which betray their presence by gravitationally sculpting such asymmetric features. The young debris disc around HD 115600, imaged recently by the Gemini Planet Imager, is such a disc with an eccentricity 0.1

  13. The value of ultrasonic evaluation for diagnosis of lumbar disc herniation

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jae Cheon [Sarang Hospitl, Seoul (Korea, Republic of); Rhim, Hyun Chul; Jeong, Woo Koeng; Lee, Seung Ro [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2001-12-15

    The aim of the investigation was to evaluate the diagnostic effectiveness of sonography in the evaluation of the lower lumbar intervertebral disc herniations. Prospective ultrasonographic examinations by transabdominal approach were performed on 65 consecutive patients (32 males and 33 females) with clinically suspected lumbar disc herniation, and the findings were compared with MR findings. The transabdominal representation of lumbar disc herniations was successful in 64 cases at L3-4 level,59 cases at L4-5 level and 55 cases at L5-S1 level. The sonographic examination wa inconclusive in the some patients because of degenerative disc with vacuum phenomenon, osteophytosis and diminution of the intervertebal disc space. Both sensitivity and specificity of sonography were 100% at L3-4 level. At the same time, the sensitivity and specificity of sonography were 60% and 97% at L4-5 level and 36% and 100% at L5-S1 level. Although ultrasound is not currently used as a screening modality because of the low sensitivity, ultrasound shows a high specificity with non-invasiveness but without radiation hazard. Therefore, ultrasound can be used as an aid for diagnosing lumbar disc herniation, especially in young men without spondylosis.

  14. Effect of Gas Accretion Disc Profile on Orbital Parameters of the Accreted Stars

    Science.gov (United States)

    Shukirgaliyev, Bekdaulet T.; Panamarev, Taras P.; Naurzbaeva, Aisha Zh.; Kalambay, Mukhagali T.; Makukov, Maxim A.; Vilkoviskij, Emmanuil Y.; Omarov, Chingis T.; Berczik, Peter; Just, Andreas; Spurzem, Rainer

    2016-10-01

    The results of studies of the effect of the gas disk and its profile on the dynamics of active galactic nuclei are presented. The study was conducted with a numerical model of galactic nucleus based on phiGRAPE+GPU comprising three subsystems - a central supermassive black hole, gaseous accretion disc, and compact stellar cluster. The evolution of the compact stellar cluster is modeled with direct integration (N-body simulation), while the black hole and gaseous disc are represented phenomenologically: the black hole is introduced as an external potential (fixed in space but variable in time due to black hole mass growth), and the gaseous disc is introduced as spatial time-independent density distribution. We examined and compared with each other orbital parameters of accreting stars for model of the galactic nucleus with gas disc of constant and variable thickness, as well as without gas. It was found that in the presence of a gaseous disk almost half of the accreted particles interact strongly with the gas and are captured by the disc before accretion, while more than 85% of particles are affected to some extent by the disc prior to accretion. This suggests that interaction of the stellar cluster with the gas disk in the galactic nucleus might lead to the formation of stellar disk in the central part of the nucleus.

  15. The young nuclear stellar disc in the SB0 galaxy NGC 1023

    CERN Document Server

    Corsini, E M; Pastorello, N; Bontà, E Dalla; Pizzella, A; Portaluri, E

    2015-01-01

    Small kinematically-decoupled stellar discs with scalelengths of a few tens of parsec are known to reside in the centre of galaxies. Different mechanisms have been proposed to explain how they form, including gas dissipation and merging of globular clusters. Using archival Hubble Space Telescope imaging and ground-based integral-field spectroscopy, we investigated the structure and stellar populations of the nuclear stellar disc hosted in the interacting SB0 galaxy NGC 1023. The stars of the nuclear disc are remarkably younger and more metal rich with respect to the host bulge. These findings support a scenario in which the nuclear disc is the end result of star formation in metal enriched gas piled up in the galaxy centre. The gas can be of either internal or external origin, i.e. from either the main disc of NGC 1023 or the nearby satellite galaxy NGC 1023A. The dissipationless formation of the nuclear disc from already formed stars, through the migration and accretion of star clusters into the galactic cen...

  16. Gravitoturbulence in magnetised protostellar discs

    CERN Document Server

    Riols, A

    2016-01-01

    Gravitational instability (GI) features in several aspects of protostellar disk evolution, most notably in angular momentum transport, fragmentation, and the outbursts exemplified by FU Ori and EX Lupi systems. The outer regions of protostellar discs may also be coupled to magnetic fields, which could then modify the development of GI. To understand the basic elements of their interaction, we perform local 2D ideal and resistive MHD simulations with an imposed toroidal field. In the regime of moderate plasma beta, we find that the system supports a hot gravito-turbulent state, characterised by considerable magnetic energy and stress and a surprisingly large Toomre parameter $Q~10$. This result has potential implications for disk structure, vertical thickness, ionisation, etc. Our simulations also reveal the existence of long-lived and dense `magnetic islands' or plasmoids. Lastly, we find that the presence of a magnetic field has little impact on the fragmentation criterion of the disk. Though our focus is on...

  17. Lumbar herniated disc: spontaneous regression

    Science.gov (United States)

    Yüksel, Kasım Zafer

    2017-01-01

    Background Low back pain is a frequent condition that results in substantial disability and causes admission of patients to neurosurgery clinics. To evaluate and present the therapeutic outcomes in lumbar disc hernia (LDH) patients treated by means of a conservative approach, consisting of bed rest and medical therapy. Methods This retrospective cohort was carried out in the neurosurgery departments of hospitals in Kahramanmaraş city and 23 patients diagnosed with LDH at the levels of L3−L4, L4−L5 or L5−S1 were enrolled. Results The average age was 38.4 ± 8.0 and the chief complaint was low back pain and sciatica radiating to one or both lower extremities. Conservative treatment was administered. Neurological examination findings, durations of treatment and intervals until symptomatic recovery were recorded. Laségue tests and neurosensory examination revealed that mild neurological deficits existed in 16 of our patients. Previously, 5 patients had received physiotherapy and 7 patients had been on medical treatment. The number of patients with LDH at the level of L3−L4, L4−L5, and L5−S1 were 1, 13, and 9, respectively. All patients reported that they had benefit from medical treatment and bed rest, and radiologic improvement was observed simultaneously on MRI scans. The average duration until symptomatic recovery and/or regression of LDH symptoms was 13.6 ± 5.4 months (range: 5−22). Conclusions It should be kept in mind that lumbar disc hernias could regress with medical treatment and rest without surgery, and there should be an awareness that these patients could recover radiologically. This condition must be taken into account during decision making for surgical intervention in LDH patients devoid of indications for emergent surgery. PMID:28119770

  18. Effects of disc asymmetries on astrometric measurements - Can they mimic planets?

    CERN Document Server

    Kral, Quentin; Kennedy, Grant; Souami, Damya

    2016-01-01

    Astrometry covers a parameter space that cannot be reached by RV or transit methods to detect terrestrial planets on wide orbits. In addition, high accuracy astrometric measurements are necessary to measure the inclination of the planet's orbits. Here we investigate the principles of an artefact of the astrometric approach. Namely, the displacement of the photo-centre due to inhomogeneities in a dust disc around the parent star. Indeed, theory and observations show that circumstellar discs can present strong asymmetries. We model the pseudo-astrometric signal caused by these inhomogeneities, asking whether a dust clump in a disc can mimic the astrometric signal of an Earth-like planet. We show that these inhomogeneities cannot be neglected when using astrometry to find terrestrial planets. We provide the parameter space for which these inhomogeneities can affect the astrometric signals but still not be detected by mid-IR observations. We find that a small cross section of dust corresponding to a cometary mass...

  19. Direct thermal imaging of circumstellar discs and exo-planets

    Science.gov (United States)

    Pantin, Eric; Siebenmorgen, Ralf; Cavarroc, Celine; Sterzik, Michael F.

    2008-07-01

    The phase A study of a mid infrared imager and spectrograph for the European Extremely Large Telescope (E-ELT), called METIS, was endorsed in May 2008. Two key science drivers of METIS are: a) direct thermal imaging of exo-planets and b) characterization of circumstellar discs from the early proto-planetary to the late debris phase. Observations in the 10μm atmospheric window (N band) require a contrast ratio between stellar light and emitted photons from the exo-planet or the disc of ~ 105. At shorter wavelengths the contrast between star and reflected light from the planet-disc system exceeds >~ 107 posing technical challenges. By means of end-to-end detailed simulations we demonstrate that the superb spatial resolution of a 42m telescope in combination with stellar light rejection methods such as coronagraphic or differential imaging will allow detections at 10μm for a solar type system down to a star-planet separation of 0.1" and a mass limit for irradiated planets of 1 Jupiter (MJ) mass. In case of self-luminous planets observations are possible further out e.g. at the separation limit of JWST of ~ 0.7", METIS will detect planets >~5MJ. This allows to derive a census of all such exo-planets by means of thermal imaging in a volume limited sample of up to 6pc. In addition, METIS will provide the possibility to study the chemical composition of atmospheres of exo-planets using spectroscopy at moderate spectral resolution (λ/Δλ ~ 100) for the brightest targets. Based on detailed performance and sensitivity estimates, we demonstrate that a mid-infrared instrument on an ELT is perfectly suited to observe gravitationally created structures such as gaps in proto- and post- planetary discs, in a complementary way to space missions (e.g. JWST, SOFIA) and ALMA which can only probe the cold dust emission further out.

  20. Stellar irradiated discs and implications on migration of embedded planets II: accreting-discs

    CERN Document Server

    Bitsch, Bertram; Lega, Elena; Crida, Aurélien

    2014-01-01

    The strength and direction of migration of embedded low mass planets depends on the disc's structure. It has been shown that, in discs with viscous heating and radiative transport, the migration can be directed outwards. In this paper we investigate the influence of a constant dM/dt-flux through the disc, as well as the influence of the disc's metallicity on the disc's thermodynamics. We focus on dM/dt discs, which have a net mass flux through them. Utilizing the resulting disc structure, we determine the regions of outward migration in the disc. We perform numerical hydrosimulations of dM/dt discs with viscous heating, radiative cooling and stellar irradiation in 2D in the r-z-plane. We use the explicit/implicit hydrodynamical code FARGOCA that includes a full tensor viscosity and stellar irradiation, as well as a two temperature solver that includes radiation transport in the flux-limited diffusion approximation. The migration of embedded planets is studied by using torque formulae. For a disc of gas surfac...

  1. Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc

    Science.gov (United States)

    Ahtiainen, Katja; Mauno, Jari; Ellä, Ville; Hagström, Jaana; Lindqvist, Christian; Miettinen, Susanna; Ylikomi, Timo; Kellomäki, Minna; Seppänen, Riitta

    2013-01-01

    The temporomandibular joint (TMJ) disc lacks functional replacement after discectomy. We investigated tissue-engineered bilayer polylactide (PLA) discs and autologous adipose stem cells (ASCs) as a potential replacement for the TMJ disc. These ASC discs were pre-cultured either in control or in differentiation medium, including transforming growth factor (TGF)-β1 for one week. Prior to implantation, expression of fibrocartilaginous genes was measured by qRT-PCR. The control and differentiated ASC discs were implanted, respectively, in the right and left TMJs of rabbits for six (n = 5) and 12 months (n = 5). Thereafter, the excised TMJ areas were examined with cone beam computed tomography (CBCT) and histology. No signs of infection, inflammation or foreign body reactions were detected at histology, whereas chronic arthrosis and considerable condylar hypertrophy were observed in all operated joints at CBCT. The left condyle treated with the differentiated ASC discs appeared consistently smoother and more sclerotic than the right condyle. The ASC disc replacement resulted in dislocation and morphological changes in the rabbit TMJ. The ASC discs pre-treated with TGF-β1 enhanced the condylar integrity. While adverse tissue reactions were not shown, the authors suggest that with improved attachment and design, the PLA disc and biomaterial itself would hold potential for TMJ disc replacement. PMID:23720535

  2. The properties of discs around planets and brown dwarfs as evidence for disc fragmentation

    CERN Document Server

    Stamatellos, Dimitris

    2015-01-01

    Direct imaging searches have revealed many very low-mass objects, including a small number of planetary mass objects, as wide-orbit companions to young stars. The formation mechanism of these objects remains uncertain. In this paper we present the predictions of the disc fragmentation model regarding the properties of the discs around such low-mass objects. We find that the discs around objects that have formed by fragmentation in discs hosted by Sun-like stars (referred to as 'parent' discs and 'parent' stars) are more massive than expected from the ${M}_{\\rm disc}-M_*$ relation (which is derived for stars with masses $M_*>0.2 {\\rm M}_{\\odot}$). Accordingly, the accretion rates onto these objects are also higher than expected from the $\\dot{M}_*-M_*$ relation. Moreover there is no significant correlation between the mass of the brown dwarf or planet with the mass of its disc nor with the accretion rate from the disc onto it. The discs around objects that form by disc fragmentation have larger than expected m...

  3. Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc.

    Science.gov (United States)

    Ahtiainen, Katja; Mauno, Jari; Ellä, Ville; Hagström, Jaana; Lindqvist, Christian; Miettinen, Susanna; Ylikomi, Timo; Kellomäki, Minna; Seppänen, Riitta

    2013-08-06

    The temporomandibular joint (TMJ) disc lacks functional replacement after discectomy. We investigated tissue-engineered bilayer polylactide (PLA) discs and autologous adipose stem cells (ASCs) as a potential replacement for the TMJ disc. These ASC discs were pre-cultured either in control or in differentiation medium, including transforming growth factor (TGF)-β1 for one week. Prior to implantation, expression of fibrocartilaginous genes was measured by qRT-PCR. The control and differentiated ASC discs were implanted, respectively, in the right and left TMJs of rabbits for six (n = 5) and 12 months (n = 5). Thereafter, the excised TMJ areas were examined with cone beam computed tomography (CBCT) and histology. No signs of infection, inflammation or foreign body reactions were detected at histology, whereas chronic arthrosis and considerable condylar hypertrophy were observed in all operated joints at CBCT. The left condyle treated with the differentiated ASC discs appeared consistently smoother and more sclerotic than the right condyle. The ASC disc replacement resulted in dislocation and morphological changes in the rabbit TMJ. The ASC discs pre-treated with TGF-β1 enhanced the condylar integrity. While adverse tissue reactions were not shown, the authors suggest that with improved attachment and design, the PLA disc and biomaterial itself would hold potential for TMJ disc replacement.

  4. Migration and kinematics in growing disc galaxies with thin and thick discs

    Science.gov (United States)

    Aumer, Michael; Binney, James; Schönrich, Ralph

    2017-09-01

    We analyse disc heating and radial migration in N-body models of growing disc galaxies with thick and thin discs. Similar to thin-disc-only models, galaxies with appropriate non-axisymmetric structures reproduce observational constraints on radial disc heating in and migration to the Solar Neighbourhood (Snhd). The presence of thick discs can suppress non-axisymmetries and thus higher baryonic-to-dark matter fractions are required than in models that only have a thin disc. Models that are baryon dominated to roughly the Solar radius R0 are favoured, in agreement with data for the Milky Way. For inside-out growing discs, today's thick-disc stars at R0 are dominated by outwards migrators. Whether outwards migrators are vertically hotter than non-migrators depends on the radial gradient of the thick-disc vertical velocity dispersion. There is an effective upper boundary in angular momentum that thick-disc stars born in the centre of a galaxy can reach by migration, which explains the fading of the high [α/Fe] sequence outside R0. Our models compare well to Snhd kinematics from Radial Velocity Survey and Tycho-Gaia Astrometric Solution data. For such comparisons, it is important to take into account the azimuthal variation of kinematics at R ∼ R0 and biases from survey selection functions. The vertical heating of thin-disc stars by giant molecular clouds is only mildly affected by the presence of thick discs. Our models predict higher vertical velocity dispersions for the oldest stars than found in the Snhd age velocity dispersion relation, possibly because of measurement uncertainties or an underestimation of the number of old cold stars in our models.

  5. Structure of radiation dominated gravitoturbulent quasar discs

    CERN Document Server

    Shadmehri, Mohsen; Dib, Sami

    2016-01-01

    Self-gravitating accretion discs in a gravitoturbulent state, including radiation and gas pressures, are studied using a set of new analytical solutions. While the Toomre parameter of the disc remains close to its critical value for the onset of gravitational instability, the dimensionless stress parameter is uniquely determined from the thermal energy reservoir of the disc and its cooling rate. Our solutions are applicable to the accretion discs with dynamically important radiation pressure like in the quasars discs. We show that physical quantities of a gravitoturbulent disc in the presence of radiation are significantly modified compared to solutions with only gas pressure. We show that the dimensionless stress parameter is an increasing function of the radial distance so that its steepness strongly depends on the accretion rate. In a disc without radiation its slope is 4.5, however, we show that in the presence of radiation, it varies between 2 and 4.5 depending on the accretion rate and the central mass....

  6. Chemical separation of disc components using RAVE

    CERN Document Server

    Wojno, Jennifer; Steinmetz, Matthias; McMillan, Paul J; Matijevič, Gal; Binney, James; Wyse, Rosemary F G; Boeche, Corrado; Just, Andreas; Grebel, Eva K; Siebert, Arnaud; Bienaymé, Olivier; Gibson, Brad K; Zwitter, Tomaž; Bland-Hawthorn, Joss; Navarro, Julio F; Parker, Quentin A; Reid, Warren; Seabroke, George; Watson, Fred

    2016-01-01

    We present evidence from the RAdial Velocity Experiment (RAVE) survey of chemically separated, kinematically distinct disc components in the solar neighbourhood. We apply probabilistic chemical selection criteria to separate our sample into $\\alpha$-low (`thin disc') and $\\alpha$-high (`thick disc') components. Using newly derived distances, which will be utilized in the upcoming RAVE DR5, we explore the kinematic trends as a function of metallicity for each of the disc components. For our thin disc stars, we find a negative trend in the mean rotational velocity ($V_{\\mathrm{\\phi}}$) as a function of iron abundance ([Fe/H]). We measure a positive trend in $\\partial V_{\\mathrm{\\phi}}$/$\\partial$[Fe/H] for the thick disc, consistent with results from high-resolution surveys. We also find differences between the chemical thin and thick discs in all three components of velocity dispersion. We discuss the implications of an $\\alpha$-low, metal-rich population originating from the inner Galaxy, where the orbits of ...

  7. Have proto-planetary discs formed planets?

    CERN Document Server

    Greaves, J S

    2010-01-01

    It has recently been noted that many discs around T Tauri stars appear to comprise only a few Jupiter-masses of gas and dust. Using millimetre surveys of discs within six local star-formation regions, we confirm this result, and find that only a few percent of young stars have enough circumstellar material to build gas giant planets, in standard core accretion models. Since the frequency of observed exo-planets is greater than this, there is a `missing mass' problem. As alternatives to simply adjusting the conversion of dust-flux to disc mass, we investigate three other classes of solution. Migration of planets could hypothetically sweep up the disc mass reservoir more efficiently, but trends in multi-planet systems do not support such a model, and theoretical models suggest that the gas accretion timescale is too short for migration to sweep the disc. Enhanced inner-disc mass reservoirs are possible, agreeing with predictions of disc evolution through self-gravity, but not adding to millimetre dust-flux as t...

  8. Optically-thick accretion discs with advection

    Institute of Scientific and Technical Information of China (English)

    陈林红; 吴枚; 尚仁成

    2002-01-01

    The structures of optically-thick accretion discs with radial advection have been investigated by the iteration and integration algorithms. The advective cooling term changes mostly the inner part of disc solution, and even results in an optically-thick advection-dominated accretion flow (ADAF). Three distinct branches-the outer Shakura-Sunyaev disc (SSD), the inner ADAF and the middle transition layer-are found for a super-Eddington disc. The SSD-ADAF transition radius can be estimated as 18(M/ME)RG where RG is the Schwarzschild radius, M is the mass accretion rate and ME is the Eddington accretion rate. SSD solutions calculated with the iteration and integration methods are identical, while ADAF solutions obtained by these two methods differ greatly. Detailed algorithms and their differences have been analysed. The iteration algorithm is not self-consistent, since it implies that the dimensionless advection factor ξ is invariant, but in the inner ADAF region the variation of ξ is not negligible. The integration algorithm is always effective for the whole region of an optically-thick disc if the accretion rate is no smaller than 10-4ME. For optically-thin discs, the validity of these two algorithms is different. We suggest that the integration method be employed to calculate the global solution of a disc model without assuming ξ to be a constant. We also discuss its application to the emergent continuum spectrum in order to explain observational facts.

  9. The tidal disruption of protoplanetary accretion discs

    CERN Document Server

    Larwood, J D

    1997-01-01

    In this paper we revisit the problem of the tidal interaction occuring between a protostellar accretion disc and a secondary point mass following a parabolic trajectory. We model the disc response analytically and we compare our results with three-dimensional SPH simulations. Inviscid as well as viscous hydrodynamics is considered. We show that in a viscous system the response derived from inviscid considerations is predominant even for the highest estimates of an anomalous disc shear viscosity. The angular momentum lost from the disc during the encounter is derived from linear theory, for distant fly-bys, as well as the changes to the disc orientation expected in non-coplanar encounters. It is shown that the target discs can become warped and precess by a small amount during non-coplanar encounters. This small precession is shown to give rise to a relative tilt of the disc which is always more important for determining its final orientation than is the change to the orbital inclination. We discuss the implic...

  10. Leaf-disc grafting for the transmission of Candidatus Liberibacter asiaticus in citrus (Citrus sinensis; Rutaceae) seedlings1

    Science.gov (United States)

    Tabay Zambon, Flavia; Plant, Karen; Etxeberria, Ed

    2017-01-01

    Premise of the study: The search for resistance/tolerance to the devastating citrus huanglongbing disease (syn. HLB or citrus greening) is generating an increasing number of new plants of diverse genetic makeup. As the increasing number of new plants require more space, resources, and time, the need for faster and more efficient HLB screening tests becomes crucial. Methods and Results: The leaf-disc grafting system described here consists in replacing a disc of leaf tissue with a similar disc from an infected plant. This can be performed in young seedlings not yet big enough to endure other types of grafting. Graft success and infection rates average approximately 80%. Conclusions: We describe the successful adaptation of leaf-disc grafting as a powerful screening tool for HLB. The system requires minimal plant material and can be performed in seedlings at a very young age with increased efficiency in terms of time, space, and resources. PMID:28090406

  11. Intradiscal pressure measurements in normal discs, compressed discs and compressed discs treated with axial posterior disc distraction: an experimental study on the rabbit lumbar spine model.

    Science.gov (United States)

    Guehring, Thorsten; Unglaub, Frank; Lorenz, Helga; Omlor, Georg; Wilke, Hans-Joachim; Kroeber, Markus W

    2006-05-01

    Intervertebral disc (IVD) pressure measurement is an appropriate method for characterizing spinal loading conditions. However, there is no human or animal model that provides sufficient IVD pressure data. The aim of our study was to establish physiological pressure values in the rabbit lumbar spine and to determine whether temporary external disc compression and distraction were associated with pressure changes. Measurements were done using a microstructure-based fibreoptic sensor. Data were collected in five control rabbits (N, measurement lying prone at segment L3/4 at day 28), five rabbits with 28 days of axial compression (C, measurement at day 28) and three rabbits with 28 days of axial compression and following 28 days of axial distraction (D, measurement at day 56). Disc compression and distraction was verified by disc height in lateral radiographs. The controls (N) showed a level-related range between 0.25 MPa-0.45 MPa. The IVD pressure was highest at level L3/4 (0.42 MPa; range 0.38-0.45) with a decrease in both cranial and caudal adjacent segments. The result for C was a significant decrease in IVD pressure (0.31 MPa) when compared with controls (P=0.009). D showed slightly higher median IVD pressure (0.32 MPa) compared to C, but significantly lower levels when compared with N (P=0.037). Our results indicate a high range of physiological IVD pressure at different levels of the lumbar rabbit spine. Temporary disc compression reduces pressure when compared with controls. These data support the hypothesis that temporary external compression leads to moderate disc degeneration as a result of degradation of water-binding disc matrix or affected active pumping mechanisms of nutrients into the disc. A stabilization of IVD pressure in discs treated with temporary distraction was observed.

  12. Endoscopic anterior decompression in cervical disc disease

    Directory of Open Access Journals (Sweden)

    Yad Ram Yadav

    2014-01-01

    Full Text Available Background: Although microscopic anterior cervical discectomy with or without fusion are common surgical procedures for treatment of cervical herniated discs, loss of disc height, pseudarthrosis, and adjacent disc degeneration are some of the problems associated with it. This study is aimed to evaluate results of endoscopic microforaminotomy in cervical disc diseases. Materials and Methods: A prospective study of 50 patients of mono segmental soft or hard disc causing myeloradiculopathy was undertaken. A visual analogue scale (VAS for neck and arm pain and functional outcomes using the Nurick grading system were assessed. There were 28, 12, 8, and 2 patients at C5-6, C6-7, C4-5, and C3-4 levels disc diseases, respectively. Patients with two or more level disc, instabilities, disc extending more than half vertebral body height, and previous operation at the same segment were excluded. Results: Age ranged from 21 to 67 years. Average postoperative reduction in disc height, operating time, and blood loss was 1.1 mm, 110 minutes, and 30 ml, respectively. Average pre-operative VAS score for arm pain and Nurick grading was 7.6 and 2.7, which improved to 1.9 and 0.82, respectively. All patients improved; 1, 2, 3 grade improvement was seen in 10, 27, and 10 patients, respectively. There was no significant complication or any mortality. Conclusion: Although longer follow up of large number of patients is required, endoscopic microforaminotomy is a safe and an effective alternative to microscopic anterior discectomy with or without fusion.

  13. A thick-disc origin for Tycho Brahe's 1572 supernova?

    Science.gov (United States)

    Fuhrmann, Klaus

    2005-05-01

    The very recent suggestion for the identification of a faint G-type subgiant, dubbed `Tycho G', as the binary progenitor of Tycho Brahe's 1572 Type Ia supernova by Ruiz-Lapuente et al. is essentially based on the peculiar space velocity of the star. Here we demonstrate that the kinematics of Tycho G are likewise in keeping with the stars of the Milky Way's thick-disc population. Hence we may well be seeing an object that is only coincidentally passing in the vicinity of the supernova remnant, or Tycho Brahe and his contemporaries may indeed have witnessed the late explosion of one of the first stars in the Galaxy.

  14. Warps and waves in fully cosmological models of galactic discs

    CERN Document Server

    Gómez, Facundo A; Grand, Robert J J; Marinacci, Federico; Springel, Volker; Pakmor, Rüdiger

    2016-01-01

    Recent studies have revealed an oscillating asymmetry in the vertical structure of the Milky Way's disc. Here we analyze 16 high-resolution, fully cosmological simulations of the evolution of individual Milky Way-sized galaxies, carried out with the MHD code AREPO. At redshift zero, about $70\\%$ of our galactic discs show strong vertical patterns, with amplitudes that can exceed 2 kpc. Half of these are typical `integral sign' warps. The rest are oscillations similar to those observed in the Milky Way. Such structures are thus expected to be common. The associated mean vertical motions can be as large as 30 km/s. Cold disc gas typically follows the vertical patterns seen in the stars. These perturbations have a variety of causes: close encounters with satellites, distant flybys of massive objects, accretion of misaligned cold gas from halo infall or from mergers. Tidally induced vertical patterns can be identified in both young and old stellar populations, whereas those originating from cold gas accretion are...

  15. Relationship of modic type 1 change with disc degeneration: a prospective MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Luoma, Katariina [Helsinki University Central Hospital, Helsinki and Uudenmaa District University Hospitals, Helsinki (Finland)]|[Peijas Hospital, Helsinki University Central Hospitals, Department of Radiology, Vantaa (Finland); Vehmas, Tapio [Institute of Occupational Health, Helsinki (Finland); Groenblad, Mats; Kaeaepae, Eeva [Helsinki and Uudenmaa District University Hospitals, Helsinki University Central Hospital, Department of Physical Medicine and Rehabilitation, Helsinki (Finland); Kerttula, Liisa [Helsinki University Central Hospital, Helsinki and Uudenmaa District University Hospitals, Helsinki (Finland)

    2009-03-15

    The objective was to study the natural course of Modic type 1 change (M1) in relation to lumbar disc degeneration. Twenty-four chronic low back pain (LBP) patients with M1 on lumbar spine were selected from 1,015 patients with magnetic resonance imaging from a follow-up study lasting for 18-74 months. Exclusion criteria were any other specific back disorder, age {>=}60 years, or a recent spine operation. The association between the development of M1 and degenerative disc changes was studied using multivariate modeling (complex samples logistic regression). At baseline, 20 of 28 (71%) disc spaces with M1 had a decreased disc height (DH) and 16 of 28 (57%) a dark nucleus pulposus, but ten of 28 (36%) a very dark annulus fibrosus and a paradoxically bright nucleus pulposus albeit decreased DH. During follow-up, DH decreased in 13 of 28 (46%) and signal intensity of nucleus pulposus (DSI) in eight of 28 (29%) disc spaces with M1, but it increased in four (14%) discs. In those without M1, only few changes occurred. The larger the M1, the more likely was the DH low or decreased further. Both the presence and changes in M1 were associated with a decrease in DH and changes in DSI and bulges. The degenerative process in discs with adjacent M1 seems to be accelerated and leads to advanced and deforming changes with special morphologic features. M1 may be a sign of a pathologic degenerative process in the discovertebral unit. (orig.)

  16. Topical vancomycine and bacterial culture from intervertebral herniated disc prevent postoperative osteodiscitis

    Directory of Open Access Journals (Sweden)

    Adam1 Danil

    2014-12-01

    Full Text Available Osteodiscitis represents a serious complication of lumbar disc herniation operations. The treatment of osteodiscitis is controversial and expensive to society. It extends over a period of several months from diagnosis. Reducing postoperative osteodiscitis by using simple measures may limit patient's suffering and reduce costs. The purpose of this study is to evaluate the early diagnosis of bacterial infections of the intervertebral disc by isolating germs located in the herniated disc fragment and topical Vancomycine powder application, along with the conventional anti-infective therapy. Medical files of patients who were operated on for lumbar disc herniations during 01.01.2013 - 30.06.2014 were reviewed. The diagnosis of lumbar disc herniation was established based on the clinical evaluation, confirmed by MRI results. The surgical intervention was performed by mini-open approach: fenestration and foraminotomy completed with removal of the herniated disc fragment and disc remnants from the intervertebral space. A group of 162 patients (group A received conventional therapy for prevention of post-operative infections with 2 doses of cephalosporin. In the second group of 137 patients (group B, after the removal of the herniated disc fragments, 1g of Vancomycine powder was topically applied and the disc fragments were bacteriologically analyzed. They received the conventional treatment of preventing post-operative infections with cephalosprin - 2 doses. The two groups of patients were similar in terms of demographic characteristics: age, sex, operative level. Out of the 162 patients of group A, one patient developed postoperative osteodiscitis and was treated for 3 months with antibiotics. Regarding patients in group B, in four cases Staphylococcus was isolated from the disc fragments. Postoperative treatment for these patients with prolonged antibiotic therapy over the standard period avoided the developement of the clinical picture of

  17. Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis.

    Science.gov (United States)

    Guehring, Thorsten; Omlor, Georg W; Lorenz, Helga; Engelleiter, Karl; Richter, Wiltrud; Carstens, Claus; Kroeber, Markus

    2006-07-01

    An animal model of degeneration was used to determine the effects of disc distraction, and was evaluated with magnetic resonance imaging (MRI) as well as gene and protein expression levels. To investigate gene expression and MRI effects of distraction. Disc degeneration can result from hyper-physiologic loading. Distracted discs with degeneration showed histologic signs of tissue recovery. There were 18 rabbits that underwent 28 days of compression (200 N) to induce moderate disc degeneration followed by 28 days of distraction (120 N; attached and loaded distraction device) or sham distraction (attached but unloaded distraction device). Comparison was performed with 56 days of compressed discs without distraction. Quantitative outcome measures were MRI signal intensity and gene expression analysis to determine: messenger ribonucleic acid levels for extracellular matrix genes, including collagen 1, collagen 2, biglycan, decorin, aggrecan, fibromodulin, and osteonectin; and matrix-regulative genes, including matrix metalloproteinase-13, tissue-inhibitor of matrix metalloproteinase-1, and bone morphogenetic protein (BMP)-2. Immunohistology was performed for collagen 2 and BMP-2 to label cells semiquantitatively by staining of the cell-surrounding matrix. A total of 28 days of compression decreased signal intensity. Distraction over the same period reestablished physiologic signal intensity, however, a persistent reduction was found in sham distraction. Distraction resulted in gene expression up-regulation of collagen 1 (5.4-fold), collagen 2 (5.5-fold), biglycan (7.7-fold), and decorin (3.4-fold), while expression of fibromodulin (0.16-fold), tissue-inhibitor of matrix metalloproteinase-1 (0.05-fold), and BMP-2 (0.15-fold) was decreased, as compared with 56 days compression. Distracted discs showed more BMP-2 (19.67 vs. 3.67 in 56 days compression) and collagen 2 (18.67 vs. 11.33 in 56 days compression) positive cells per field. Distraction results in disc rehydration

  18. Spectroscopic Parameters of Lumbar Intervertebral Disc Material

    Science.gov (United States)

    Terbetas, G.; Kozlovskaja, A.; Varanius, D.; Graziene, V.; Vaitkus, J.; Vaitkuviene, A.

    2009-06-01

    There are numerous methods of investigating intervertebral disc. Visualization methods are widely used in clinical practice. Histological, imunohistochemical and biochemical methods are more used in scientific research. We propose that a new spectroscopic investigation would be useful in determining intervertebral disc material, especially when no histological specimens are available. Purpose: to determine spectroscopic parameters of intervertebral disc material; to determine emission spectra common for all intervertebral discs; to create a background for further spectroscopic investigation where no histological specimen will be available. Material and Methods: 20 patients, 68 frozen sections of 20 μm thickness from operatively removed intervertebral disc hernia were excited by Nd:YAG microlaser STA-01-TH third harmonic 355 nm light throw 0, 1 mm fiber. Spectrophotometer OceanOptics USB2000 was used for spectra collection. Mathematical analysis of spectra was performed by ORIGIN multiple Gaussian peaks analysis. Results: In each specimen of disc hernia were found distinct maximal spectral peaks of 4 types supporting the histological evaluation of mixture content of the hernia. Fluorescence in the spectral regions 370-700 nm was detected in the disc hernias. The main spectral component was at 494 nm and the contribution of the components with the peak wavelength values at 388 nm, 412 nm and 435±5 nm were varying in the different groups of samples. In comparison to average spectrum of all cases, there are 4 groups of different spectral signatures in the region 400-500 nm in the patient groups, supporting a clinical data on different clinical features of the patients. Discussion and Conclusion: besides the classical open discectomy, new minimally invasive techniques of treating intervertebral disc emerge (PLDD). Intervertebral disc in these techniques is assessed by needle, no histological specimen is taken. Spectroscopic investigation via fiber optics through the

  19. Modeling and Thermal Analysis of Disc

    OpenAIRE

    Brake Praveena S; Lava Kumar M

    2014-01-01

    The disc brake is a device used for slowing or stopping the rotation of the vehicle. Number of times using the brake for vehicle leads to heat generation during braking event, such that disc brake undergoes breakage due to high Temperature. Disc brake model is done by CATIA and analysis is done by using ANSYS workbench. The main purpose of this project is to study the Thermal analysis of the Materials for the Aluminum, Grey Cast Iron, HSS M42, and HSS M2. A comparison between ...

  20. A lumbar disc surgery predictive score card.

    Science.gov (United States)

    Finneson, B E

    1978-06-01

    A lumbar disc surgery predictive score card or questionnaire has been developed to assess potential candidates for excision of a herniated lumbar disc who have not previously undergone lumbar spine surgery. It is not designed to encompass patients who are being considered for other types of lumbar spine surgery, such as decompressive laminectomy or fusion. In an effort to make the "score card" usable by almost all physicians who are involved in lumbar disc surgery, only studies which have broad acceptance and are generally employed are included. Studies which have less widespread use such as electromyogram, discogram, venogram, special psychologic studies (MMPI, pain drawings) have been purposely excluded.

  1. Interrelationship between mandibular congealer head position in trasncranial view and articular disc position

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Jae Hee; Choi, Soon Chul; You, Dong Soo [Dept. of Oral and Maxillofacial Radiology, Graduate School, Seoul National University, Seoul (Korea, Republic of)

    1995-08-15

    This study was designed to evaluate the interrelationship between the congealer head position in transcranial view and the articular disc position in the arthrography. The condylar positions were assessed by subjective method and linear measurement method on the transcranial view. The subjects for this study consisted of 24 symptomatic joints with normal disc position, 37 joints with anterior disc displacement with reduction and 44 joints with anterior disc displacement without reduction that were classified by arthrotomography under the fluoroscopic guidance. The interrelationship between the condylar head position in transcranial view and the articualr disc position in the arthrography was evaluated by Chi square test. The following results were obtained: 1. There was no significant interrelationship between the position of congealer head in closed mouth state on transcranial view and articular disc position in the arthrography (p>0.05). 2. There was no significant interrelationship between the changes of interarticular distance in 1 inch opening state and articular disc position in the arthrography (p>0.05). 3. There was no significant interrelationship between the position of condylar head related to the apex of articular eminence in 1 inch opening state and articular disc position in the arthrography (p>0.05). 4. There was significant interrelationship between the changes of interarticular distance that is assessed by linear measurement method in maximum opening state and articular disc position in the arthrography (p<0.05), but there was no significant interrelationship when the condylar head position was assessed by subjective method (p>0.05). 5. There was significant interrelationship between the degree of condylar translation in maximum opening state and articular disc position in the arthrography (p<0.01). 6. The correlation coefficient between two methods to assess the position of condylar head were 0.7989: the condylar head position in articular fossa

  2. Text-mining network analysis of the response to osmotic stimuli in the intervertebral disc.

    Science.gov (United States)

    Xu, X; Liu, L; Lu, Q Y

    2013-05-13

    Intervertebral disc cells experience a broad range of physical stimuli under physiologic conditions, including alterations in their osmotic environment. The purpose of this study was to construct a text-mining network of the genes induced during the response to osmotic stimuli in the intervertebral disc. We obtained a gene expression profile of human intervertebral disc cells from the National Center for Biotechnology Information, after culture under hyper- and hypo-osmotic conditions compared to iso-osmotic conditions, and we identified 65 differentially expressed genes of intervertebral disc cells. We constructed a text-mining network using Biblio-MetReS between the differentially expressed genes and other genes that were included in the same document as the differentially expressed genes. Then, we performed pathway-enrichment analysis to identify the most relevant pathways for the response to osmotic stimuli in intervertebral disc cells. Our data provide a comprehensive bioinformatics analysis of genes and pathways that may be involved in the response to osmotic stimuli in the intervertebral disc.

  3. Tribological properties of C/C-SiC composites for brake discs

    Science.gov (United States)

    Jang, G. H.; Cho, K. H.; Park, S. B.; Lee, W. G.; Hong, U. S.; Jang, H.

    2010-02-01

    This study examines the friction and wear of ceramic matrix composites designed for use in automotive brake discs. The composites are produced by reinforcing a SiC matrix with carbon fibers using a liquid silicon infiltration method. C/C-SiC composites with two different compositions are fabricated to examine the compositional effect on the tribological properties. The tribological properties are evaluated using a scale dynamometer with a low-steel type friction material. The results show that the coefficient of friction is determined by the composition of the composite, which affects the propensity of friction film formation on the disc surface. A stable friction film on the disc surface also improves the wear resistance by diminishing the abrasive action of the disc. On the other hand, the friction film formation on the disc is affected by the applied pressure, and stable films are obtained at high pressures. This trend is prominent with discs with high Si content. However, both C/C/-SiC composites show superior performance in terms of the friction force oscillation, which is closely related to brake-induced vibration.

  4. Genomic polymorphism and protein changes of soybean mutant induced by space environment

    Science.gov (United States)

    He, J.; Gao, Y.; Sun, Y.

    Soybean 194 4126 of excellent agricultural qualities such as high yield and rounder and wider leaf was selected in six generation after abroad recoverable satellite 15 days in 1996 from Soybean 72163 featured with long-leaf white-blossom grey-hair and infinitude-poding To explore the mechanisms of plant mutation induced by space environment we have experimented at genome and proteome level on Soybean 194 4126 and its control Soybean 72163 Amplified Fragment Length Polymorphism AFLP was used to identify mutated sits and the result shows that 36 polymorphic bands varying between 100 and 900 bp in 2022 DNA bands varying between 100 and 1500 bp have been amplified out of 64 pairs of primer combinations between mutant Soybean 194 4126 and the control plant So the mutation degree of DNA is 3 56 The protein two-dimensional electrophoresis 2-DE and peptide mass fingerprint PMF assays were used to investigate the difference of proteins in fruits and leaves between Soybean 194 4126 and its control Results indicate that 62 protein dots specially appear in Soybean 72163 and 39 dots specially in the mutant Soybean 194 4126 by image analysis software PDQuest in the 2-DE maps of soybean seeds Using PMF assay and protein data-base searching to investigate two distinct protein dots we found that the protein specially expressed in the seed of mutant Soybean 194 4126 may be Dehydrin and the other protein specially expressed in the seed of the control Soybean 72163 may be maturation-associated protein MAT1 Because Dehydrin and MAT1 are

  5. Bisphosphonate as a Countermeasure to Space Flight-Induced Bone Loss

    Science.gov (United States)

    Spector, Elisabeth; LeBlanc, A.; Sibonga, J.; Matsumoto, T.; Jones, J.; Smith, S. M.; Shackelford, L.; Shapiro, J.; Lang, T.; Evans, H.; Spector, E.; Nakamura, T.; Kohri, K.; Ohshima, H.

    2009-01-01

    The purpose of this research is to determine whether anti-resorptive pharmaceuticals such as bisphosphonates, in conjunction with the routine in-flight exercise program, will protect ISS crewmembers from the regional decreases in bone mineral density and bone strength and the increased renal stone risk documented on previous long-duration space flights [1-3]. Losses averaged 1 to 2 percent per month in such regions as the lumbar spine and hip. Although losses showed significant heterogeneity among individuals and between bones within a given subject, space flight-induced bone loss was a consistent finding. More than 90 percent of astronauts and cosmonauts on long-duration flights (average 171 days) aboard Mir and the ISS, had a minimum 5 percent loss in at least one skeletal site, 40 percent of them had a 10 percent or greater loss in at least one skeletal site, and 22 percent of the Mir cosmonauts experienced a 15 to 20 percent loss in at least one site. These losses occurred even though the crewmembers performed time-consuming in-flight exercise regimens. Moreover, a recent study of 16 ISS astronauts using quantitative computed tomography (QCT) demonstrated trabecular bone losses from the hip averaging 2.3 percent per month [4]. These losses were accompanied by significant losses in hip bone strength that may not be recovered quickly [5]. This rapid loss of bone mass results from a combination of increased and uncoupled remodeling, as demonstrated by increased resorption with little or no change in bone formation markers [6-7]. This elevated remodeling rate likely affects the cortical and trabecular architecture and may lead to irreversible changes. In addition to bone loss, the resulting hypercalciuria increases renal stone risk. Therefore, it is logical to attempt to attenuate this increased remodeling with anti-resorption drugs such as bisphosphonates. Success with alendronate was demonstrated in a bed rest study [8]. This work has been extended to space

  6. Mapping radiation-induced defects in CCDs through space and time

    Science.gov (United States)

    Hall, David; Bush, Nathan; Wood, Daniel; Murray, Neil J.; Gow, Jason; Skottfelt, Jesper; Holland, Andrew

    2016-08-01

    cycle of these traps through time after irradiation. In orbit, most devices will be operating cold to suppress dark current and the devices are therefore cold whilst undergoing damage from the radiation environment. The mobility of defects varies as a function of temperature such that the mix of defects present following a cryogenic irradiation may vary significantly from that found following a room temperature irradiation or after annealing. It is therefore essential to study the trap formation and migration in orbit-like conditions and over longer timescales. In this paper we present a selection of the latest methods and results in the trap pumping of n- and p-channel devices and demonstrate how this technique now allows us to map radiation-induced defects in CCDs through both space and time.

  7. Efficiency of thermal relaxation by radiative processes in protoplanetary discs: constraints on hydrodynamic turbulence

    Science.gov (United States)

    Malygin, M. G.; Klahr, H.; Semenov, D.; Henning, Th.; Dullemond, C. P.

    2017-09-01

    Context. Hydrodynamic, non-magnetic instabilities can provide turbulent stress in the regions of protoplanetary discs, where the magneto-rotational instability can not develop. The induced motions influence the grain growth, from which formation of planetesimals begins. Thermal relaxation of the gas constrains origins of the identified hydrodynamic sources of turbulence in discs. Aims: We aim to estimate the radiative relaxation timescale of temperature perturbations in protoplanetary discs. We study the dependence of the thermal relaxation on the perturbation wavelength, the location within the disc, the disc mass, and the dust-to-gas mass ratio. We then apply thermal relaxation criteria to localise modes of the convective overstability, the vertical shear instability, and the zombie vortex instability. Methods: For a given temperature perturbation, we estimated two timescales: the radiative diffusion timescale tthick and the optically thin emission timescale tthin. The longest of these timescales governs the relaxation: trelax = max (tthick, tthin). We additionally accounted for the collisional coupling to the emitting species. Our calculations employed the latest tabulated dust and gas mean opacities. Results: The relaxation criterion defines the bulk of a typical T Tauri disc as unstable to the development of linear hydrodynamic instabilities. The midplane is unstable to the convective overstability from at most 2au and up to 40au, as well as beyond 140au. The vertical shear instability can develop between 15au and 180au. The successive generation of (zombie) vortices from a seeded noise can work within the inner 0.8au. Conclusions: A map of relaxation timescale constrains the origins of the identified hydrodynamic turbulence-driving mechanisms in protoplanetary discs. Dynamic disc modelling with the evolution of dust and gas opacities is required to clearly localise the hydrodynamic turbulence, and especially its non-linear phase.

  8. A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

    Energy Technology Data Exchange (ETDEWEB)

    Purmessur, D.; Walter, B.A. [Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Roughley, P.J. [Shriners Hospital for Children, Montreal, QC (Canada); Laudier, D.M.; Hecht, A.C. [Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States); Iatridis, James, E-mail: james.iatridis@mssm.edu [Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (United States)

    2013-03-29

    Highlights: ► TNFα induced catabolic changes similar to human intervertebral disc degeneration. ► The metabolic shift induced by TNFα was sustained following removal. ► TNFα induced changes suggestive of cell senescence without affecting cell viability. ► Interventions are required to stimulate anabolism and increase cell proliferation. -- Abstract: This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the chronic inflammatory state commonly found with painful IDD. Pro-inflammatory cytokines such as TNFα contribute to disc pathology and are implicated in the catabolic phenotype associated with painful IDD. Whole bovine discs were cultured to examine cellular (anabolic/catabolic gene expression, cell viability and senescence using β-galactosidase) and structural (histology and aggrecan degradation) changes in response to TNFα treatment. Control or TNFα cultures were assessed at 7 and 21 days; the 21 day group also included a recovery group with 7 days TNFα followed by 14 days in basal media. TNFα induced catabolic and anti-anabolic shifts in the nucleus pulposus (NP) and annulus fibrosus (AF) at 7 days and this persisted until 21 days however cell viability was not affected. Data indicates that TNFα increased aggrecan degradation products and suggests increased β-galactosidase staining at 21 days without any recovery. TNFα treatment of whole bovine discs for 7 days induced changes similar to the degeneration processes that occur in human IDD: aggrecan degradation, increased catabolism, pro-inflammatory cytokines and nerve growth factor expression. TNFα significantly reduced anabolism in cultured IVDs and a possible mechanism may be associated with cell senescence. Results therefore suggest that successful treatments must promote anabolism and cell proliferation in

  9. Stellar irradiated discs and implications on migration of embedded planets I: equilibrium discs

    CERN Document Server

    Bitsch, Bertram; Morbidelli, Alessandro; Kley, Willy; Dobbs-Dixon, Ian

    2012-01-01

    The strength and direction of migration of low mass planets depends on the disc's thermodynamics. In discs where the viscous heating is balanced by radiative transport, the migration can be directed outwards, a process which extends the lifetime of growing planetary embryos. We investigate the influence of opacity and stellar irradiation on the disc thermodynamics. Utilizing the resulting disc structure, we determine the regions of outward migration. We perform two-dimensional numerical simulations of equilibrium discs with viscous heating, radiative cooling and stellar irradiation. We use the hydrodynamical code NIRVANA that includes a full tensor viscosity and stellar irradiation, as well as a two temperature solver that includes radiation transport in the flux-limited diffusion approximation. The migration is studied by using torque formulae. In the constant opacity case, we reproduce the analytical results of a black-body disc: the stellar irradiation dominates in the outer regions -- leading to flaring -...

  10. Investigation of the coatings applied onto brake discs on disc-brake pad pair

    Directory of Open Access Journals (Sweden)

    I. Kiliçaslan

    2009-07-01

    Full Text Available While braking, according to the severity of it, thermal, metallurgical, constructive and tribological occurrences emerge on the brake disc-pad interface. In this study, NiCr was sprayed as bonding layer onto the discs, one ofwhich was coated with Al2O3-TiO2 by plasma spray and the other was coated with NiCr-Cr3C2 by High Velocity Oxygen Fuel (HVOF. In addition, the discs were tested with inertia dynamometer according to SAE’s J2522 testing procedure. The measurements showed that although the pads of the coated discs were exposed to higher braking temperatures, friction coefficient of the disc coated with NiCr- Cr3C2 was obtained 6 % higher compared to the original disc.

  11. Burned-out discs stop hurting: fact or fiction?

    DEFF Research Database (Denmark)

    Bendix, Tom; Kjaer, Per; Korsholm, Lars

    2008-01-01

    ). The risk for LBP during the past year attributed to black discs was 11%. CONCLUSION: The data could not support the hypothesis that severely degenerated discs are "burned out" and become less painful. People with black discs had a higher prevalence of LBP compared to those with grey or normal discs...

  12. Cervical disc arthroplasty with ProDisc-C artificial disc: 5-year radiographic follow-up results

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yan-bin; SUN Yu; ZHOU Fei-fei; LIU ZHONG-jun

    2013-01-01

    Background Cervical disc arthroplasty is an alternative surgery to standard cervical decompression and fusion for disc degeneration.Different types of cervical disc prosthesis are used in China.The aim of this study was to evaluate the radiographic outcomes of cervical arthroplasty using the ProDisc-C prosthesis.Methods Radiographic evaluation,including static and dynamic flexion-extension lateral images,was performed at baseline and at final follow-up.Results Twenty six patients who had single-level ProDisc-C arthroplasty were followed up for a mean period of 63 months (56-76 months).The range of motion at the operated level was 9.3°±3.7° at baseline and 7.3°±3.5° at final follow-up,with a significant difference (P <0.05).Seventeen of 26 levels (65.4%) developed heterotopic ossification:three were classified as grade Ⅱ,13 were classified as grade Ⅲ,and 1 as grade Ⅳ,according to McAfee's classification.Forty nine adjacent segments were evaluated by lateral Ⅹ-ray and 18 (36.7%) segments developed adjacent segment degenerations.Conclusions ProDisc-C arthroplasty had acceptable radiographic results at 5-year follow-up.The range of motion was preserved.However,more than 60% of the patients developed heterotopic ossification.

  13. The study on space-flight induced DNA damage in Arabidopsis thaliana and the protective effect of hydrogen

    Science.gov (United States)

    Sun, Qiao; Liu, Min; Zhao, Hui

    2016-07-01

    Ionizing radiation (IR) is a known mutagen responsible for causing DNA strand breaks in all living organisms. Strand breaks thus created can be repaired by different mechanisms, including homologous recombination (HR), one of the key mechanisms maintaining genome stability. Here, we used previously generated Arabidopsis thaliana, transgenic for homologous recombination reporter system, in which homologous recombination frequency(HRF) was used as mutagenic end points. Based on the system, effect of DNA damage by space-flight during the Shenzhou-9 mission was investigated and the results showed that 13 days space-flight exposure of seedlings induced a significant increase in HRF compared with its ground-base three-dimensional clinostat controls and ground 1g controls. We also observed three-dimensional clinostat induced a significant increase in HRF compared with ground 1g controls. Molecular hydrogen (H2) has antioxidant activities by selectively reducing hydroxylradical ( •OH) and peroxynitrite(ONOO-), so we investigated the effect of hydrogen on IR-induced HRF. Treatment with hydrogen-rich water dramatically reduced the HR frequency induced by exposure of seedlings to 0 to 80 Gy 60Co radiation , suggesting that hydrogen represents a potentially novel preventative strategy for radiation-induced DNA damage in plants.

  14. Medium-term outcomes of artificial disc replacement for severe cervical disc narrowing

    Institute of Scientific and Technical Information of China (English)

    Chao-Hung Yeh; Che-Wei Hung; Cheng-Hsing Kao; Chien-Ming Chao

    2014-01-01

    Objective:To determine if theBryan cervical disc prosthesis could relieve objective neurological symptoms, signs, and restore mobility in patients with severe cervical disc narrowing. Methods:Clinical data of thirty-two patients underwentBryan cervical disc replacement has been collected fromApril2006 toFebruary2010.Severe cervical disc narrowing with gradeV disc degeneration were included in this study.Bryan cervical disc prostheses have been implanted through anterior approach.JapaneseOrthopedicsAssociation(JOA) score, visual analog scale, Odom’s scale, and flexion-extension radiological follow-ups were applied for evaluations. Results:A total of41Bryan disc prostheses from32 patients with an average follow-up duration of33.5 months(range23 to44 months) were evaluated.Clinical functions of patients were significantly improved.Preoperative averaged visual analog scale score of6.3±2.2 was decreased to1.3±1.2(at36 months,P<0.001), while preoperative averagedJOA score of14.4±1.2 was increased to16.3±0.9(at36 months,P<0.001).Thirty of32 patients received excellent to good outcomes inOdom’s scale.Averaged mobility was restored to(9.9±3.2)°at the last follow-up evaluation of36 months.No subsidence or migration of implant was identified. Conclusions:Acceptable clinical outcome for treatment of severe cervical disc narrowing with cervical disc replacement technique has been performed in current study.Most patients maintained good postoperative mobility and no significant adjacent level degeneration were found.Cervical disc replacement may be applicable in treatment of severe cervical disc narrowing; however, longer follow-ups are required for ensuring the long-term efficacy of cervical disc replacement.

  15. CD, DVD, and Blu-Ray Disc Diffraction with a Laser Ray Box

    Science.gov (United States)

    DeWeerd, Alan J.

    2016-01-01

    A compact disc (CD) can be used as a diffraction grating, even though its track consists of a series of pits, not a continuous groove. Previous authors described how to measure the track spacing on a CD using an incident laser beam normal to the surface or one at an oblique angle. In both cases, the diffraction pattern was projected on a screen…

  16. 2D-Zernike Polynomials and Coherent State Quantization of the Unit Disc

    Energy Technology Data Exchange (ETDEWEB)

    Thirulogasanthar, K., E-mail: santhar@gmail.com [Concordia University, Department of Comuter Science and Software Engineering (Canada); Saad, Nasser, E-mail: nsaad@upei.ca [University of Prince Edward Island, Department of mathematics and Statistics (Canada); Honnouvo, G., E-mail: g-honnouvo@yahoo.fr [McGill University, Department of Mathematics and Statistics (Canada)

    2015-12-15

    Using the orthonormality of the 2D-Zernike polynomials, reproducing kernels, reproducing kernel Hilbert spaces, and ensuring coherent states attained. With the aid of the so-obtained coherent states, the complex unit disc is quantized. Associated upper symbols, lower symbols and related generalized Berezin transforms also obtained. A number of necessary summation formulas for the 2D-Zernike polynomials proved.

  17. CD, DVD, and Blu-Ray Disc Diffraction with a Laser Ray Box

    Science.gov (United States)

    DeWeerd, Alan J.

    2016-01-01

    A compact disc (CD) can be used as a diffraction grating, even though its track consists of a series of pits, not a continuous groove. Previous authors described how to measure the track spacing on a CD using an incident laser beam normal to the surface or one at an oblique angle. In both cases, the diffraction pattern was projected on a screen…

  18. Space Charge Behavior in Paper Insulation Induced by Copper Sulfide in High-Voltage Direct Current Power Transformers

    Directory of Open Access Journals (Sweden)

    Ruijin Liao

    2015-08-01

    Full Text Available The main insulation system in high-voltage direct current (HVDC transformer consists of oil-paper insulation. The formation of space charge in insulation paper is crucial for the dielectric strength. Unfortunately, space charge behavior changes because of the corrosive sulfur substance in oil. This paper presents the space charge behavior in insulation paper induced by copper sulfide generated by corrosive sulfur in insulation oil. Thermal aging tests of paper-wrapped copper strip called the pigtail model were conducted at 130 °C in laboratory. Scanning electron microscopy (SEM was used to observe the surface of copper and paper. Pulse electroacoustic (PEA and thermally stimulated current (TSC methods were used to obtain the space charge behavior in paper. Results showed that both maximum and total amount of space charge increased for the insulation paper contaminated by semi-conductor chemical substance copper sulfide. The space charge decay rate of contaminated paper was significantly enhanced after the polarization voltage was removed. The TSC results revealed that copper sulfide increased the trap density and lowered the shallow trap energy levels. These results contributed to charge transportation by de-trapping and trapping processes. This improved charge transportation could be the main reason for the decreased breakdown voltage of paper insulation material.

  19. Effect of Electro-acupuncture on Matrix Metalloproteinase in Degenerated Cervical Intervertebral Disc of Rats

    Institute of Scientific and Technical Information of China (English)

    SHI Zheng; HUANG Qiang; MA Xiao-peng; LIU Shi-min; LIU Hui-rong; ZHU Zhong-chun

    2007-01-01

    To observe the effect of electro-acupuncture on matrix metalloproteinase in degenerated cervical intervertebral disc rats.Methods:The rat model of cervical intervertebral disc degeneration was induced by unbalanced dynamic and static forces,then the rats were randomly allocated to model group,electro-acupuncture groupⅠ(acupoints Dazhu(BL 11) and Tianzhu(BL 10) were electro-acupunctured),and electro-acupuncture group Ⅱ(acupoints Dazhu (BL 11),Tianzhu(BL 10)and Shenshu(BL 23) were electro-acupunctured),with the normal rats as control.then the HE staining method was adopted to observe the morphological change of cervical intervertebral disc and the immunohistochemical staining method was used to detect the marx metalloproteinases-1(MMP-1) and matrix metalloproteinases-3(MMP-3) in cervical intervertebral disc.Results:The morphological observation showed that after electro-acupuncture treatment,the degrees of cervical intervertebral disc degeneration in electro-acupuncture groupⅠand electro-acupuncture group Ⅱ were alleviated,and the electro-acupuncture group Ⅱ was superior to electro-acupuncture group Ⅰ.The expressions of MMP-1 and MMP-3 in degenerated cervical intervertebral disc were increased(P<0.01),and after electro-acupuncture treatment,the expressions of MMP-1 and MMP-3 in degenerated cervical intervertebral disc were decreased,especially the electro-acupuncture group Ⅱpresented the better effect as compared with electro-acupuncture group Ⅰ(P<0.05).Conclusions:Electro-acupuncture at acupoints Dazhu (BL 11) and Tianzhu (BL 10) had a certain therapeutic effect on cervical intervertebral disc degeneration,and in combination with acupoint Shenshu(BL 23),this therapeutic effect could be enhanced,its action mechanism might be that electro-acupuncture can reduce the expressions of MMP-l and MMP-3 in degenerated cervical intervertebral disc,inhibit the degradation of matrix in intervertebral disc.so as to relieve cervical intervertebral disc

  20. Highly inclined and eccentric massive planets. II. Planet-planet interactions during the disc phase

    Science.gov (United States)

    Sotiriadis, Sotiris; Libert, Anne-Sophie; Bitsch, Bertram; Crida, Aurélien

    2017-02-01

    Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined and eccentric massive planets has shown that the damping induced by the disc is significant for a massive planet, leading the planet back to the midplane with its eccentricity possibly increasing over time. Aims: We aim to investigate the influence of the eccentricity and inclination damping due to planet-disc interactions on the final configurations of the systems, generalizing previous studies on the combined action of the gas disc and planet-planet scattering during the disc phase. Methods: Instead of the simplistic K-prescription, our N-body simulations adopt the damping formulae for eccentricity and inclination provided by the hydrodynamical simulations of our companion paper. We follow the orbital evolution of 11 000 numerical experiments of three giant planets in the late stage of the gas disc, exploring different initial configurations, planetary mass ratios and disc masses. Results: The dynamical evolutions of the planetary systems are studied along the simulations, with a particular emphasis on the resonance captures and inclination-growth mechanisms. Most of the systems are found with small inclinations (≤ 10°) at the dispersal of the disc. Even though many systems enter an inclination-type resonance during the migration, the disc usually damps the inclinations on a short timescale. Although the majority of the multiple systems in our simulations are quasi-coplanar, 5% of them end up with high mutual inclinations (≥ 10°). Half of these highly mutually inclined systems result from two- or three-body mean-motion resonance captures, the other half being

  1. Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc

    Directory of Open Access Journals (Sweden)

    Mwale F.

    2004-12-01

    Full Text Available Tissue engineering of intervertebral discs (IVD using mesenchymal stem cells (MSCs induced to differentiate into a disc-cell phenotype has been considered as an alternative treatment for disc degeneration. However, since there is no unique marker characteristic of discs and since hyaline cartilage and immature nucleus pulposus (NP possess similar macromolecules in their extracellular matrix, it is currently difficult to recognize MSC conversion to a disc cell. This study was performed to compare the proteoglycan to collagen ratio (measured as GAG to hydroxyproline ratio in the NP of normal disc to that of the hyaline cartilage of the endplate within the same group of individuals and test the hypothesis that this ratio can be used for in vivo studies to distinguish between a normal NP and hyaline cartilage phenotype. Whole human lumbar spine specimens from fresh cadavers, ranging in age from 12 weeks to 79 years, were used to harvest the IVDs and adjacent endplates. The GAG to hydroxyproline ratio within the NP of young adults is approximately 27:1, whereas the ratio within the hyaline cartilage endplate of the same aged individuals is about 2:1. The production of an extracellular matrix with a high proteoglycan to collagen ratio can be used in vivo to distinguish NP cells from chondrocytes, and could help in identifying a NP-like phenotype in vivo as opposed to a chondrocyte when MSCs are induced to differentiate for tissue engineering of a disc.

  2. A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

    Science.gov (United States)

    Kohonen, Pekka; Parkkinen, Juuso A; Willighagen, Egon L; Ceder, Rebecca; Wennerberg, Krister; Kaski, Samuel; Grafström, Roland C

    2017-07-03

    Predicting unanticipated harmful effects of chemicals and drug molecules is a difficult and costly task. Here we utilize a 'big data compacting and data fusion'-concept to capture diverse adverse outcomes on cellular and organismal levels. The approach generates from transcriptomics data set a 'predictive toxicogenomics space' (PTGS) tool composed of 1,331 genes distributed over 14 overlapping cytotoxicity-related gene space components. Involving ∼2.5 × 10(8) data points and 1,300 compounds to construct and validate the PTGS, the tool serves to: explain dose-dependent cytotoxicity effects, provide a virtual cytotoxicity probability estimate intrinsic to omics data, predict chemically-induced pathological states in liver resulting from repeated dosing of rats, and furthermore, predict human drug-induced liver injury (DILI) from hepatocyte experiments. Analysing 68 DILI-annotated drugs, the PTGS tool outperforms and complements existing tests, leading to a hereto-unseen level of DILI prediction accuracy.

  3. Axial T2* mapping in intervertebral discs: a new technique for assessment of intervertebral disc degeneration

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, Sven; Quirbach, Sebastian; Krause, Fabian G.; Benneker, Lorin M. [Inselspital, Berne University Hospital, Department of Orthopaedic Surgery, Berne (Switzerland); Mamisch, Tallal C. [Inselspital, Berne University Hospital, Department of Radiology, Berne (Switzerland); Werlen, Stefan [Clinic Sonnenhof, Department of Radiology, Berne (Switzerland)

    2012-09-15

    To demonstrate the potential benefits of biochemical axial T2* mapping of intervertebral discs (IVDs) regarding the detection and grading of early stages of degenerative disc disease using 1.5-Tesla magnetic resonance imaging (MRI) in a clinical setting. Ninety-three patients suffering from lumbar spine problems were examined using standard MRI protocols including an axial T2* mapping protocol. All discs were classified morphologically and grouped as ''healthy'' or ''abnormal''. Differences between groups were analysed regarding to the specific T2* pattern at different regions of interest (ROIs). Healthy intervertebral discs revealed a distinct cross-sectional T2* value profile: T2* values were significantly lower in the annulus fibrosus compared with the nucleus pulposus (P = 0.01). In abnormal IVDs, T2* values were significantly lower, especially towards the centre of the disc representing the expected decreased water content of the nucleus (P = 0.01). In herniated discs, ROIs within the nucleus pulposus and ROIs covering the annulus fibrosus showed decreased T2* values. Axial T2* mapping is effective to detect early stages of degenerative disc disease. There is a potential benefit of axial T2* mapping as a diagnostic tool, allowing the quantitative assessment of intervertebral disc degeneration. circle Axial T2* mapping effective in detecting early degenerative disc disease. (orig.)

  4. Treatment of lumbar disc herniation by percutaneous laser disc decompression (PLDD) and modified PLDD

    Science.gov (United States)

    Chi, Xiao fei; Li, Hong zhi; Wu, Ru zhou; Sui, Yun xian

    2005-07-01

    Objective: To study the micro-invasive operative method and to compare the effect of treatment of PLDD and modified PLDD for Lumbar Disc Herniation. Method: Vaporized part of the nucleus pulposus in single or multiple point after acupuncture into lumbar disc, to reach the purpose of the decompression of the lumbar disc. Result: Among the 19 cases of the regular PLDD group, the excellent and good rate was 63.2%, and among the 40 cases of the modified PLDD group, the excellent and good rate was 82.5%. Conclusion: The modified PLDD has good effect on the treatment for lumbar disc herniation.

  5. Transradicular lumbar disc herniation: An extreme variant of intraradicular disc herniation.

    Science.gov (United States)

    Kasliwal, Manish K; Shimer, Adam L

    2015-01-01

    Intradural or intraradicular lumbar disc herniation (IDH) is a relatively rare condition often diagnosed intraoperatively. We encountered an extreme variant of IDH - a transradicular herniation as the disc material extruded through the lumbar nerve root through a split essentially transecting the nerve root. While failure to recognize intradural and intraradicular disc herniation can lead to failed back surgery, the variant described in the present case could lead to iatrogenic injury and complication if not recognized. A unique case of transradicular lumbar disc herniation in a 25-year-old patient is presented with the depiction of intraoperative images supplementing the text.

  6. CFD Analysis Of Straight Ventilated Disc Brake

    Directory of Open Access Journals (Sweden)

    Nikhil K

    2016-05-01

    Full Text Available Brakes are the key pieces of a vehicle that plays an active role in safety and performance of the system. The study of aerodynamic cooling of a disc brake in real working condition of vehicle is important in present situations. Brake discs get very hot quickly, so it should be dissipated properly through different modes of heat transfer. Contributions of these heat transfer modes are different in different type of problems. The cooling transfer rates are different in vane surface and frictional surface of a disc brake. Also the temperature varies in each small interval of braking time. So a transient problem simulation is important to study the cooling of a disc brake when a vehicle decelerates from a particular speed. ANSYS CFX tool is used for the simulation of this transient problem.

  7. Modeling and Thermal Analysis of Disc

    Directory of Open Access Journals (Sweden)

    Brake Praveena S

    2014-10-01

    Full Text Available The disc brake is a device used for slowing or stopping the rotation of the vehicle. Number of times using the brake for vehicle leads to heat generation during braking event, such that disc brake undergoes breakage due to high Temperature. Disc brake model is done by CATIA and analysis is done by using ANSYS workbench. The main purpose of this project is to study the Thermal analysis of the Materials for the Aluminum, Grey Cast Iron, HSS M42, and HSS M2. A comparison between the four materials for the Thermal values and material properties obtained from the Thermal analysis low thermal gradient material is preferred. Hence best suitable design, low thermal gradient material Grey cast iron is preferred for the Disc Brakes for better performance.

  8. Magnetic Field Amplification via Protostellar Disc Dynamos

    CERN Document Server

    Dyda, Sergei; Ustyugova, Galina V; Koldoba, Alexander V; Wasserman, Ira

    2015-01-01

    We model the generation of a magnetic field in a protostellar disc using an \\alpha-dynamo and perform axisymmetric magnetohydrodynamics (MHD) simulations of a T Tauri star. We find that for small values of the dimensionless dynamo parameter $\\alpha_d$ the poloidal field grows exponentially at a rate ${\\sigma} \\propto {\\Omega}_K \\sqrt{\\alpha_d}$ , before saturating to a value $\\propto \\sqrt{\\alpha_d}$ . The dynamo excites dipole and octupole modes, but quadrupole modes are suppressed, because of the symmetries of the seed field. Initial seed fields too weak to launch MHD outflows are found to grow sufficiently to launch winds with observationally relevant mass fluxes of order $10^{-9} M_{\\odot}/\\rm{yr}$ for T Tauri stars. For large values of $\\alpha_d$ magnetic loops are generated over the entire disc. These quickly come to dominate the disc dynamics and cause the disc to break up due to the magnetic pressure.

  9. Thermal analysis on motorcycle disc brake geometry

    Science.gov (United States)

    W. M. Zurin W., S.; Talib, R. J.; Ismail, N. I.

    2017-08-01

    Braking is a phase of slowing and stop the movement of motorcycle. During braking, the frictional heat was generated and the energy was ideally should be faster dissipated to surrounding to prevent the built up of the excessive temperature which may lead to brake fluid vaporization, thermoelastic deformation at the contact surface, material degradation and failure. In this paper, solid and ventilated type of motorcycle disc brake are being analyse using Computational Fluid Dynamic (CFD) software. The main focus of the analysis is the thermal behaviour during braking for solid and ventilated disc brake. A comparison between both geometries is being discussed to determine the better braking performance in term of temperature distribution. It is found that ventilated disc brake is having better braking performance in terms of heat transfer compare to solid disc.

  10. Stellar Wind Erosion of Protoplanetary Discs

    CERN Document Server

    Schnepf, Neesha R; Romanova, Marina

    2014-01-01

    An analytic model is developed for the erosion of protoplanetary gas discs by high velocity magnetized stellar winds. The winds are centrifugally driven from the surface of rapidly rotating, strongly magnetized young stars. The presence of the magnetic field in the wind leads to Reynolds numbers sufficiently large to cause a strongly turbulent wind/disk boundary layer which entrains and carries away the disc gas. The model uses the conservation of mass and momentum in the turbulent boundary layer. The time-scale for significant erosion depends on the disc accretion speed, accretion rate and on the wind mass loss rate. The time-scale is estimated to be ~2E6 yr. The stellar wind erosion may act in conjunction with photo-evaporation of the discs.

  11. Spiral shocks and accretion in discs

    Energy Technology Data Exchange (ETDEWEB)

    Spruit, H.C.; Matsuda, T.; Inoue, M.; Sawada, K.

    1987-12-01

    Recent numerical and analytical results on disc-like accretion with shock waves as the only dissipation mechanism are compared. The global properties of the process are similar to those of the viscous (..cap alpha..) disc model, but precise values of the effective ..cap alpha.. value as a function of the accretion rate can be calculated. At low values of the ratio of specific heats (..gamma.. < 1.45) accretion is possible without radiative losses. Such adiabatic accretion can occur in practice at high accretion rates on to low mass objects and may be important in the formation of planets. Following previous authors, it is pointed out that non-axisymmetric perturbations in the outer parts of a disc increase in amplitude as they propagate in and cause spiral shocks more easily in a disc than perturbations originating in the inner parts.

  12. [Disc electrophoresis of collagen protein (author's transl)].

    Science.gov (United States)

    Reitmayr, P; Verzár, F

    1975-01-01

    The composition of proteins extracted from tendon collagen is investigated by disc electrophoresis. No qualitative differences can be demonstrated between young and old collagen. The action of formaldehyde and methionine on the tendons has no effect on the electrophoretic picture.

  13. Clumps and Axisymmetric Features in Debris Discs

    CERN Document Server

    Jiang, Ing-Guey

    2013-01-01

    This paper studied the structures of debris discs, focusing on the conditions that can form an axisymmetric-looking outer disc from systems with inner clumps. The main conclusion was that as long as the dominated dust grains are smaller than the blowout size, it is easy to form an axisymmetric-looking outer debris disc, which is part of a quasi-steady state of the whole system. This quasi-steady state is established through the balance between grain generations and a continuous out-going grain flow. Assuming there is an event that starts planetesimal collisions and the corresponding grain generations, this balance can be approached in a few thousand years. This result suggested that a quasi-steady-state picture could solve the possible mass budget problem of Vega's outer debris disc.

  14. A simple model for the estimation of rain-induced attenuation along earth-space paths at millimeter wavelengths

    Science.gov (United States)

    Stutzman, W. L.; Dishman, W. K.

    1982-12-01

    A simple attenuation model (SAM) is presented for estimating rain-induced attenuation along an earth-space path. The rain model uses an effective spatial rain distribution which is uniform for low rain rates and which has an exponentially shaped horizontal rain profile for high rain rates. When compared to other models, the SAM performed well in the important region of low percentages of time, and had the lowest percent standard deviation of all percent time values tested.

  15. Massive thin accretion discs. Pt. 2; Polarization

    Energy Technology Data Exchange (ETDEWEB)

    Laor, A.; Netzer, H. (Tel Aviv Univ. (Israel)); Piran, T. (Hebrew Univ., Jerusalem (Israel). Racah Inst. of Physics)

    1990-02-15

    Thin accretion discs around massive black holes are believed to produce much of the observed optical-UV emission from AGN. Classical calculations predict that this radiation is highly polarized at large inclination angles, in contrast to observations of quasars and Seyfert galaxies. We have calculated the spectrum and polarization of such discs using an improved radiative transfer method with all the relevant opacity sources, and a full general relativistic treatment of the radiation propagation. (author).

  16. Lyman edges in AGN accretion discs

    Energy Technology Data Exchange (ETDEWEB)

    Czerny, B. (Copernicus Astronomical Center, Warsaw (Poland)); Pojmanski, G. (Warsaw Univ. (Poland). Obserwatorium Astronomiczne)

    1990-07-01

    We show that the basic difference in the two principal approaches to predictions of the Lyman edge in an accretion disc lies in the implicit assumption about the density of the radiating gas. Independent from the details, models predict a broad range of the edge sizes, both in absorption and in emission. Observed spectra do not exhibit any strong feature at 912 A but may still be consistent with an accretion disc mechanism if more advanced theory is developed. (author).

  17. The Annulus Property of Simple Holomorphic Discs

    CERN Document Server

    Zehmisch, Kai

    2010-01-01

    We show that any simple holomorphic disc admits the annulus property, i.e., each interior point is surrounded by an arbitrary small annulus consisting entirely of injective points. As an application we show that interior singularities of holomorphic discs can be resolved after slight perturbation of the involved almost complex structure. Moreover, for boundary points the analogue notion, the half-annulus property, is introduced and studied in detail.

  18. The annulus property of simple holomorphic discs

    OpenAIRE

    Zehmisch, Kai

    2013-01-01

    We show that any simple holomorphic disc admits the annulus property, i.e., each interior point is surrounded by an arbitrary small annulus consisting entirely of injective points. As an application we show that interior singularities of holomorphic discs can be resolved after slight perturbation of the almost complex structure. Moreover, for boundary points the analogue notion, the half-annulus property, is introduced and studied in detail.

  19. Phase diagram of mixtures of hard colloidal spheres and discs: a free-volume scaled-particle approach.

    Science.gov (United States)

    Oversteegen, S M; Lekkerkerker, H N W

    2004-02-01

    Phase diagrams of mixtures of colloidal hard spheres with hard discs are calculated by means of the free-volume theory. The free-volume fraction available to the discs is determined from scaled-particle theory. The calculations show that depletion induced phase separation should occur at low disc concentrations in systems now experimentally available. The gas-liquid equilibrium of the spheres becomes stable at comparable size ratios as with bimodal mixtures of spheres or mixtures of rods and spheres. Introducing finite thickness of the platelets gives rise to a significant lowering of the fluid branch of the binodal. Copyright 2004 American Institute of Physics

  20. Gene expression profile analysis of human intervertebral disc degeneration

    OpenAIRE

    Kai Chen; Dajiang Wu; Xiaodong Zhu; Haijian Ni; Xianzhao Wei; Ningfang Mao; Yang Xie; Yunfei Niu; Ming Li

    2013-01-01

    In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less degenerated discs were identified by significant analysis of microarray. A total of 555 genes were signi...

  1. Clumpy Disc and Bulge Formation

    CERN Document Server

    Perez, J; Tissera, P; Michel-Dansac, L

    2013-01-01

    We present a set of hydrodynamical/Nbody controlled simulations of isolated gas rich galaxies that self-consistently include SN feedback and a detailed chemical evolution model, both tested in cosmological simulations. The initial conditions are motivated by the observed star forming galaxies at z ~ 2-3. We find that the presence of a multiphase interstellar media in our models promotes the growth of disc instability favouring the formation of clumps which in general, are not easily disrupted on timescales compared to the migration time. We show that stellar clumps migrate towards the central region and contribute to form a classical-like bulge with a Sersic index, n > 2. Our physically-motivated Supernova feedback has a mild influence on clump survival and evolution, partially limiting the mass growth of clumps as the energy released per Supernova event is increased, with the consequent flattening of the bulge profile. This regulation does not prevent the building of a classical-like bulge even for the most ...

  2. Radio Monitoring of Protoplanetary Discs

    Science.gov (United States)

    Ubach, C.; Maddison, S. T.; Wright, C. M.; Wilner, D. J.; Lommen, D. J. P.; Koribalski, B.

    2017-01-01

    Protoplanetary disc systems observed at radio wavelengths often show excess emission above that expected from a simple extrapolation of thermal dust emission observed at short millimetre wavelengths. Monitoring the emission at radio wavelengths can be used to help disentangle the physical mechanisms responsible for this excess, including free-free emission from a wind or jet, and chromospheric emission associated with stellar activity. We present new results from a radio monitoring survey conducted with Australia Telescope Compact Array over the course of several years with observation intervals spanning days, months and years, where the flux variability of 11 T Tauri stars in the Chamaeleon and Lupus star forming regions was measured at 7 and 15 mm and 3 and 6 cm. Results show that for most sources are variable to some degree at 7 mm, indicating the presence of emission mechanisms other than thermal dust in some sources. Additionally, evidence of grain growth to cm-sized pebbles was found for some sources that also have signs of variable flux at 7 mm. We conclude that multiple processes contributing to the emission are common in T Tauri stars at 7 mm and beyond, and that a detection at a single epoch at radio wavelengths should not be used to determine all processes contributing to the emission.

  3. Blast-Resistance Inheritance of Space-Induced Rice Lines and Their Genomic Polymorphism by Microsatellite Markers

    Institute of Scientific and Technical Information of China (English)

    XIAO Wu-ming; YANG Qi-yun; CHEN Zhi-qiang; WANG Hui; GUO Tao; LIU Yong-zhu; ZHU Xiao-yuan

    2009-01-01

    To understand the resistance inheritance basis of space-induced rice lines to blast,and to probe mutants'genomic DNA polymorphism compared with ground control by microsatellite markers,three space-induced lines were crossed with a highly susceptible variety LTH,and their F1 and F2 populations were inoculated by two representative blast isolates with broad pathogenicity to analyze their resistance inheritance basis.Meanwhile three mutant lines and the ground control were analyzed by 225 rice SSR(simple sequence repeat)primer pairs selected throughout the 12 chromosomes of whole rice genome,to scan the mutagenesis in genome of the mutant lines.The results indicated the blast-resistant genes harbored in these mutant lines were dominant.It was demonstrated that the resistance of mutant H1 to isolate GD0193 and GD3286 was controlled by a single gene,respectively;while mutants H2 and H3 were controlled by two pairs of major genes against isolate GD3286 and H2 showed complicated genetic mechanism to isolate GD0193.H3's resistance to isolate GD0193 was verified to be controlled by a single gene.According to the results of SSR analysis,three mutant lines showed different mutant rates as compared with the ground control,and the mutant rates also varied.Resistance genes can be induced from rice by space mutation,and different genomic variations were detected in blast-resistant lines.

  4. The maximum rotation of a galactic disc

    CERN Document Server

    Bottema, R

    1997-01-01

    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously rising rotation curve until the outermost measured radial position. That is why a general relation has been derived, giving the maximum rotation for a disc depending on the luminosity, surface brightness, and colour of the disc. As a physical basis of this relation serves an adopted fixed mass-to-light ratio as a function of colour. That functionality is consistent with results from population synthesis models and its absolute value is determined from the observed stellar velocity dispersions. The derived maximum disc rotation is compared with a number of observed maximum rotations, clearly demonstrating the need for appreciable amounts of dark matter in the disc region and even more so for LSB galaxies. Matters h...

  5. Magnetic white dwarfs with debris discs

    CERN Document Server

    Külebi, Baybars; Lorén-Aguilar, Pablo; Isern, Jordi; García-Berro, Enrique

    2013-01-01

    It has long been accepted that a possible mechanism for explaining the existence of magnetic white dwarfs is the merger of a binary white dwarf system, as there are viable mechanisms for producing sustainable magnetic fields within the merger product. However, the lack of rapid rotators in the magnetic white dwarf population has been always considered a problematic issue of this scenario. Smoothed Particle Hydrodynamics simulations show that in mergers in which the two white dwarfs have different masses a disc around the central compact object is formed. If the central object is magnetized it can interact with the disc through its magnetosphere. The torque applied by the disc changes the spin of the star, whereas the transferred angular momentum from the star to the disc determines the properties of the disc. In this work we build a model for the disc evolution under the effect of magnetic accretion, and for the angular momentum evolution of the star, which can be compared with the observations. Our model pre...

  6. Turbulent drag reduction through oscillating discs

    CERN Document Server

    Wise, Daniel J

    2014-01-01

    The changes of a turbulent channel flow subjected to oscillations of wall flush-mounted rigid discs are studied by means of direct numerical simulations. The Reynolds number is $R_\\tau$=$180$, based on the friction velocity of the stationary-wall case and the half channel height. The primary effect of the wall forcing is the sustained reduction of wall-shear stress, which reaches a maximum of 20%. A parametric study on the disc diameter, maximum tip velocity, and oscillation period is presented, with the aim to identify the optimal parameters which guarantee maximum drag reduction and maximum net energy saving, computed by taking into account the power spent to actuate the discs. This may be positive and reaches 6%. The Rosenblat viscous pump flow is used to predict the power spent for disc motion in the turbulent channel flow and to estimate localized and transient regions over the disc surface subjected to the turbulent regenerative braking effect, for which the wall turbulence exerts work on the discs. The...

  7. The Diversity of Thick Galactic Discs

    CERN Document Server

    Kasparova, Anastasia V; Chilingarian, Igor V; Silchenko, Olga K; Moiseev, Alexey V; Borisov, Svyatoslav B

    2016-01-01

    Although thick stellar discs are detected in nearly all edge-on disc galaxies, their formation scenarios still remain a matter of debate. Due to observational difficulties, there is a lack of information about their stellar populations. Using the Russian 6-m telescope BTA we collected deep spectra of thick discs in three edge-on S0-a disc galaxies located in different environments: NGC4111 in a dense group, NGC4710 in the Virgo cluster, and NGC5422 in a sparse group. We see intermediate age (4-5 Gyr) metal rich ([Fe/H] $\\sim$ -0.2 - 0.0 dex) stellar populations in NGC4111 and NGC4710. On the other hand, NGC5422 does not harbour young stars, its disc is thick and old (10 Gyr), without evidence for a second component, and its $\\alpha$-element abundance suggests a 1.5-2 Gyr long formation epoch implying its formation at high redshift. Our results suggest the diversity of thick disc formation scenarios.

  8. Understanding How Space Travel Affects Blood Vessels: Arterial Remodeling and Functional Adaptations Induced by Microgravity

    Science.gov (United States)

    Delp, Michael; Vasques, Marilyn; Aquilina, Rudy (Technical Monitor)

    2002-01-01

    Ever rise quickly from the couch to get something from the kitchen and suddenly feel dizzy? With a low heart rate and relaxed muscles, the cardiovascular system does not immediately provide the resistance necessary to keep enough blood going to your head. Gravity wins, at least for a short time, before your heart and blood vessels can respond to the sudden change in position and correct the situation. Actually, the human cardiovascular system is quite well adapted to the constant gravitational force of the Earth. When standing, vessels in the legs constrict to prevent blood from collecting in the lower extremities. In the space environment, the usual head-to-foot blood pressure and tissue fluid gradients that exist during the upright posture on Earth are removed. The subsequent shift in fluids from the lower to the upper portions of the body triggers adaptations within the cardiovascular system to accommodate the new pressure and fluid gradients. In animal models that simulate microgravity, the vessels in the head become more robust while those in the lower limbs become thin and lax. Similar changes may also occur in humans during spaceflight and while these adaptations are appropriate for a microgravity environment, they can cause problems when the astronauts return to Earth or perhaps another planet. Astronauts often develop orthostatic intolerance which means they become dizzy or faint when standing upright. This dizziness can persist for a number of days making routine activities difficult. In an effort to understand the physiological details of these cardiovascular adaptations, Dr. Michael Delp at Texas A&M University, uses the rat as a model for his studies. For the experiment flown on STS-107, he will test the hypothesis that blood vessels in the rats' hindlimbs become thinner, weaker, and constrict less in response to pressure changes and to chemical signals when exposed to microgravity. In addition, he will test the hypothesis that arteries in the brain

  9. The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress

    Directory of Open Access Journals (Sweden)

    Olga Krupkova

    2016-01-01

    Full Text Available Oxidative stress-related phenotypic changes and a decline in the number of viable cells are crucial contributors to intervertebral disc degeneration. The polyphenol epigallocatechin 3-gallate (EGCG can interfere with painful disc degeneration by reducing inflammation, catabolism, and pain. In this study, we hypothesized that EGCG furthermore protects against senescence and/or cell death, induced by oxidative stress. Sublethal and lethal oxidative stress were induced in primary human intervertebral disc cells with H2O2 (total n=36. Under sublethal conditions, the effects of EGCG on p53-p21 activation, proliferative capacity, and accumulation of senescence-associated β-galactosidase were tested. Further, the effects of EGCG on mitochondria depolarization and cell viability were analyzed in lethal oxidative stress. The inhibitor LY249002 was applied to investigate the PI3K/Akt pathway. EGCG inhibited accumulation of senescence-associated β-galactosidase but did not affect the loss of proliferative capacity, suggesting that EGCG did not fully neutralize exogenous radicals. Furthermore, EGCG increased the survival of IVD cells in lethal oxidative stress via activation of prosurvival PI3K/Akt and protection of mitochondria. We demonstrated that EGCG not only inhibits inflammation but also can enhance the survival of disc cells in oxidative stress, which makes it a suitable candidate for the development of novel therapies targeting disc degeneration.

  10. The fluid dynamics of work transfer in the non-uniform viscous rotating flow within a Tesla disc turbomachine

    Science.gov (United States)

    Guha, Abhijit; Sengupta, Sayantan

    2014-03-01

    In this article, the fluid dynamics of work transfer within the narrow spacing (usually of the order of 100 μm) of multiple concentric discs of a Tesla disc turbomachine (turbine or compressor) has been analysed theoretically and computationally. Both the overall work transfer and its spatial development have been considered. It has been established that the work transfer mechanism in a Tesla disc turbomachine is very different from that in a conventional turbomachine, and the formulation of the Euler's work equation for the disc turbomachine contains several conceptual subtleties because of the existence of complex, three dimensional, non-uniform, viscous flow features. A work equivalence principle has been enunciated, which establishes the equality between the magnitudes of work transfer determined rigorously from two different approaches—one based on the shear stress acting on the disc surfaces and the other based on the change in angular momentum of the fluid. Care is needed in identifying the shear stress components that are responsible for the generation or absorption of useful power. It is shown from the Reynolds transport theorem that mass-flow-averaged tangential velocities (as opposed to the normally used area-averaged values) must be used in determining the change in angular momentum; the calculation has to be carefully formulated since both radial velocity (that determines throughput) and tangential velocity (that generates torque) depend strongly on the coordinate perpendicular to the disc surfaces. The principle of work transfer has been examined both in the absolute and relative frames of reference, revealing the subtle role played by Coriolis force. The concept of a new non-dimensional quantity called the torque potential fraction (Δ tilde H) is introduced. The value of Δ tilde H at any radial position increases with a decrease in inter-disc spacing. The computational fluid dynamic analysis shows that, for small value of inter-disc spacing and

  11. 成骨蛋白-1对髓核抽吸术后兔腰椎间盘组织病理变化的影响%The influence of osteogenic protein-1 on histologic changes of rabbit lumbar disc induced by aspiring the nucleus pulposus

    Institute of Scientific and Technical Information of China (English)

    刘航涛; 林国叶; 李平生; 林智军; 黄云梅; 陈国仙; 王万明

    2013-01-01

    Objectives: To observe the influence of osteogenic protein-1 (OP-1) on disc histologic changes induced by aspirating the nucleus pulposus. Methods: All the 32 Japanese rabbits' posterior annulus fibrosus of L1/2 and L3/4 disc were stabbed by 21-gauge hypodermic needle, then some nucleus pulposus tissues were aspirated out. 25μl OP-1 was injected into L3/4 disc by using micro-injection syringe as the experimental group (OP-1 group). 25μl normal saline was taken injected into L1/2 as a blank control disc(Saline group). L2/3 was taken as a normal control disc(normal group). At 2, 4, 8 and 12 weeks after operation, each 8 rabbits were executed and the disc tissues of L1/2, L2/3, L3/4 were harvested and sliced rapidly, stained by Masson for observation. Results: In the normal intervertebral disc, nucleus pulposus tissue collagen was sparse and lined orderly. The cells were distributed as island. Anulus fibrosus collagen fibers were lined regularly, without distortion and delamination. The intervertebral disc showed no significant pathological change at 2, 4, 8 and 12 weeks after operation. In saline group at 2 weeks after operation, excalation of the nucleus pulposus, collagen disarrangement and a large inhomogeneous amorphous particles could be observed. At 4 weeks after operation, the nucleus pulposus tissue formed cracks. More cartilage cells appeared. Collagen fibers were seriously distorted. At 8 weeks after operation, nucleus pulposus tissue had wide fissure. Collagen was arranged extremely disorder. A few cells appeared just between cartilage -like cells and fibroblasts. Layered fissure was formed. Collagen fibers were extremely distorted, with part of fracture evidenced. Gelatinous nucleus pulposus of disc showed significant fibrosis at 12 weeks after operation. Fibroblasts increased in nucleus pulposus region, and the number of cartilage-like cells decreased. The annulus fibrosus appeared huge layered fissure, with part of fracture evidenced. In OP-1 group at

  12. Dynamic, six-axis stiffness matrix characteristics of the intact intervertebral disc and a disc replacement.

    Science.gov (United States)

    Holsgrove, Timothy P; Gill, Harinderjit S; Miles, Anthony W; Gheduzzi, Sabina

    2015-11-01

    Thorough pre-testing is critical in assessing the likely in vivo performance of spinal devices prior to clinical use. However, there is a lack of data available concerning the dynamic testing of lumbar (porcine model) total disc replacements in all six axes under preload conditions. The aim of this study was to provide new data comparing porcine lumbar spinal specimen stiffness between the intact state and after the implantation of an unconstrained total disc replacement, in 6 degrees of freedom. The dynamic, stiffness matrix testing of six porcine lumbar isolated disc specimens was completed using triangle waves at a test frequency of 0.1 Hz. An axial preload of 500 N was applied during all testing. Specimens were tested both in the intact condition and after the implantation of the total disc replacement. Sixteen key stiffness terms were identified for the comparison of the intact and total disc replacement specimens, comprising the 6 principal stiffness terms and 10 key off-axis stiffness terms. The total disc replacement specimens were significantly different to the intact specimens in 12 of these key terms including all six principal stiffness terms. The implantation of the total disc replacement resulted in a mean reduction in the principal stiffness terms of 100%, 91%, and 98% in lateral bending, flexion-extension, and axial rotation, respectively. The novel findings of this study have demonstrated that the unconstrained, low-friction total disc replacement does not replicate the stiffness of the intact specimens. It is likely that other low-friction total disc replacements would produce similar results due to stiffness being actively minimised as part of the design of low-friction devices, without the introduction of stiffening elements or mechanisms to more accurately replicate the mechanical properties of the natural intervertebral disc. This study has demonstrated, for the first time, a method for the quantitative comparative mechanical function

  13. The role of disc self-gravity in circumbinary planet systems - I. Disc structure and evolution

    Science.gov (United States)

    Mutter, Matthew M.; Pierens, Arnaud; Nelson, Richard P.

    2017-03-01

    We present the results of two-dimensional hydrodynamic simulations of self-gravitating circumbinary discs around binaries whose parameters match those of the circumbinary planet-hosting systems Kepler-16, Kepler-34 and Kepler-35. Previous work has shown that non-self-gravitating discs in these systems form an eccentric precessing inner cavity due to tidal truncation by the binary, and planets which form at large radii migrate until stalling at this cavity. Whilst this scenario appears to provide a natural explanation for the observed orbital locations of the circumbinary planets, previous simulations have failed to match the observed planet orbital parameters. The aim of this work is to examine the role of self-gravity in modifying circumbinary disc structure as a function of disc mass, prior to considering the evolution of embedded circumbinary planets. In agreement with previous work, we find that for disc masses between one and five times the minimum mass solar nebula (MMSN), disc self-gravity affects modest changes in the structure and evolution of circumbinary discs. Increasing the disc mass to 10 or 20 MMSN leads to two dramatic changes in disc structure. First, the scale of the inner cavity shrinks substantially, bringing its outer edge closer to the binary. Secondly, in addition to the eccentric inner cavity, additional precessing eccentric ring-like features develop in the outer regions of the discs. If planet formation starts early in the disc lifetime, these changes will have a significant impact on the formation and evolution of planets and precursor material.

  14. Differential expression of microRNAs in the intervertebral disc of hypoxia-inducible factor-1alpha deficient mice%MicroRNAs在缺氧诱导因子1α缺失椎间盘组织中的差异性表达

    Institute of Scientific and Technical Information of China (English)

    孟祥超; 刘卓超; 王君; 周琦; 齐进; 张兴凯

    2016-01-01

    背景:MicroRNAs在椎间盘退变的疾病中起重要作用,缺氧诱导因子缺失可加速椎间盘的退变。  目的:检测缺氧诱导因子1α后小鼠椎间盘内microRNAs的变化情况,探究microRNAs与椎间盘退变的关系及缺氧诱导因子1α调控椎间盘退变机制和通路。  方法:通过前期构建的条件性敲除髓核细胞缺氧诱导因子1α基因的小鼠,分别取基因敲除组与正常对照组4周龄小鼠的椎间盘组织进行组织学染色观察;通过提取标本的总RNAs,从中分离microRNAs,荧光标记后与微阵列芯片杂交,扫描检测后数据经分析处理,筛选椎间盘组织中microRNA差异表达谱。采用实时荧光定量RT-PCR技术验证在椎间盘组织中均存在显著差异表达的microRNAs。分析差异表达microRNAs的靶基因及通路,预测其在椎间盘退变中的作用。  结果与结论:缺氧诱导因子1α基因缺失小鼠椎间盘髓核细胞数量减少,细胞形态变小,细胞质着色加深;两组小鼠椎间盘中的microRNAs的芯片筛选结果中,10个microRNAs发生了明显的差异表达,其中有7个microRNAs发生上调,3个microRNAs发生下调。结果提示缺氧诱导因子1α缺失后可能引起某些重要的microRNAs调节失衡,引起椎间盘髓核细胞大量的死亡,加速椎间盘的退变。%BACKGROUND:It is confirmed that the absence of hypoxia-inducible factor-1α (HIF-1α) accelerates the degenerative process in the intervertebral discs, and microRNAs have an important role in degeneration of the intervertebral discs. OBJECTIVE:To evaluate the changes of microRNAs in the intervertebral discs of HIF-1α-deficient (HIF-1α-/-) mice which may mediate the signaling pathway of HIF-1α in the intervertebral discs. METHODS: As previously reported, HIF-1α-/- mice were established. HIF-1α-/- mice and HIF-1αflox/flox mice (control mice) aged 4 weeks were used. MRI and histological staining were

  15. Effects of time delay and space on herbivore dynamics: linking inducible defenses of plants to herbivore outbreak

    Science.gov (United States)

    Sun, Gui-Quan; Wang, Su-Lan; Ren, Qian; Jin, Zhen; Wu, Yong-Ping

    2015-01-01

    Empirical results indicate that inducible defenses of plants have effects on herbivore populations. However, little is known about how inducible defenses of plants have influences on herbivore outbreak when space effect is considered. To reveal the relationship between inducible defenses and herbivore outbreak, we present a mathematical model to describe the interaction of them. It was found that time delay plays dual effects in the persistence of herbivore populations: (i) large value of time delay may be associated with small density of herbivore populations, and thus causes the populations to run a higher risk of extinction; (ii) moderate value of time delay is beneficial for maintaining herbivore density in a determined range which may promote the persistence of herbivore populations. Additionally, we revealed that interaction of time delay and space promotes the growth of average density of herbivore populations during their outbreak period which implied that time delay may drive the resilience of herbivore populations. Our findings highlight the close relationship between inducible defenses of plants and herbivore outbreak. PMID:26084812

  16. Effects of time delay and space on herbivore dynamics: linking inducible defenses of plants to herbivore outbreak.

    Science.gov (United States)

    Sun, Gui-Quan; Wang, Su-Lan; Ren, Qian; Jin, Zhen; Wu, Yong-Ping

    2015-06-18

    Empirical results indicate that inducible defenses of plants have effects on herbivore populations. However, little is known about how inducible defenses of plants have influences on herbivore outbreak when space effect is considered. To reveal the relationship between inducible defenses and herbivore outbreak, we present a mathematical model to describe the interaction of them. It was found that time delay plays dual effects in the persistence of herbivore populations: (i) large value of time delay may be associated with small density of herbivore populations, and thus causes the populations to run a higher risk of extinction; (ii) moderate value of time delay is beneficial for maintaining herbivore density in a determined range which may promote the persistence of herbivore populations. Additionally, we revealed that interaction of time delay and space promotes the growth of average density of herbivore populations during their outbreak period which implied that time delay may drive the resilience of herbivore populations. Our findings highlight the close relationship between inducible defenses of plants and herbivore outbreak.

  17. Possible space flight-induced catecholamine cardiomyopathy: Neil Armstrong's last 20 lunar minutes

    Directory of Open Access Journals (Sweden)

    Rowe WJ

    2014-01-01

    Full Text Available William J RoweFormer Assistant Clinical Professor of Medicine, Medical University of Ohio at Toledo, Ohio, USAAbstract: The hypothesis underpinning this paper is that space flight may predispose to catecholamine cardiomyopathy. Catecholamine levels in space are twice those of the supine levels on Earth. Serum magnesium levels are significantly reduced, with potential vicious cycles triggered by elevation of catecholamines. These are conducive to coronary vasospasm with clot formation from oxidative stress and calcium overload, and ultimately, temporary impairment of left ventricular function could occur. Experimental animals in space have shown a significant increase in norepinephrine levels with various microcirculatory disorders and serious myocardial pathology. During extravehicular activity (space walks, astronauts show heart rates of 150–174 beats per minute. Before exposure to the iron-laden dust brought into the habitat on his space suit, Neil Armstrong's heart rates on the lunar surface were 130–160 beats per minute, and accompanied by dyspnea on two occasions during his last 20 minutes on the moon. A stress test done on the day after splashdown was consistent with "ischemic left ventricular dysfunction". To support this hypothesis, echocardiography on the international space station might show left ventricular hypokinesia. Alpha adrenergic blockade, correction of invariable significant magnesium deficits, along with correction of invariable atrial natriuretic peptide deficits, may counteract the vasoconstrictive action of norepinephrine.Keywords: space flight, catecholamines, cardiomyopathy, magnesium, oxidative stress, heat intolerance, calcium

  18. Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: An in vivo study.

    Science.gov (United States)

    Grunert, Peter; Borde, Brandon H; Towne, Sara B; Moriguchi, Yu; Hudson, Katherine D; Bonassar, Lawrence J; Härtl, Roger

    2015-10-01

    Open annular defects compromise the ability of the annulus fibrosus to contain nuclear tissue in the disc space, and therefore lead to disc herniation with subsequent degenerative changes to the entire intervertebral disc. This study reports the use of riboflavin crosslinked high-density collagen gel for the repair of annular defects in a needle-punctured rat-tail model. High-density collagen has increased stiffness and greater hydraulic permeability than conventional low-density gels; riboflavin crosslinking further increases these properties. This study found that treating annular defects with crosslinked high-density collagen inhibited the progression of disc degeneration over 18 weeks compared to untreated control discs. Histological sections of FITC-labeled collagen gel revealed an early tight attachment to host annular tissue. The gel was subsequently infiltrated by host fibroblasts which remodeled it into a fibrous cap that bridged the outer disrupted annular fibers and partially repaired the defect. This repair tissue enhanced retention of nucleus pulposus tissue, maintained physiological disc hydration, and preserved hydraulic permeability, according to MRI, histological, and mechanical assessments. Degenerative changes were partially reversed in treated discs, as indicated by an increase in nucleus pulposus size and hydration between weeks 5 and 18. The collagen gel appeared to work as an instant sealant and by enhancing the intrinsic healing capabilities of the host tissue.

  19. MHD Flow of an Oldroyd-B Fluid through a Porous Space Induced by Sawtooth Pulses

    Institute of Scientific and Technical Information of China (English)

    Masood Khan; Zeeshan

    2011-01-01

    @@ We investigate the unsteady magnetohydrodynamic (MHD) flow of an Oldroyd-B fluid through a porous space inducedby sawtooth pulses.The fluid is assumed to be electrically conducting in the presence of a transverse uniform magnetic field.The porous space is taken into account using modified Darcy's law for the Oldroyd-B fluid.Exact solutions of the governing problem are obtained by using the Laplace transform method.The effects of the magnetic parameter, the permeability of the porous space and the elasticity parameter of the fluid are studied on the flow characteristics.

  20. Space space space

    CERN Document Server

    Trembach, Vera

    2014-01-01

    Space is an introduction to the mysteries of the Universe. Included are Task Cards for independent learning, Journal Word Cards for creative writing, and Hands-On Activities for reinforcing skills in Math and Language Arts. Space is a perfect introduction to further research of the Solar System.

  1. The study on space-flight induced DNA damage in Arabidopsis thaliana using the related homologous recombination reporter system

    Science.gov (United States)

    Sun, Qiao; Nechitailo, Galina S.; Lu, Jinying; Liu, Min; Li, Huasheng

    Usually, phenotype changes of plants were used to analayze the responding genetic damages. However, this method is time-consuming, laborious and needs a long period. Here, we developed an Arabidopsis thaliana homologous recombination reporter system, in which HR frequency and HR-related AtRAD54 gene expression level were used as mutagenic end points. Based on the system, effect of DNA damage by space-flight during the Shenzhou-9 mission was investigated. In this study, an Arabidopsis thaliana-line transgenic for GUS recombination substrates (R3L66, AtRAD54promoter:: GFP + GUS) was used to study the mutagenicity of space-flight, and the results showed that 13 days space-flight exposure of seedlings induced a significant increase in HRF compared with its ground-base three-dimensional clinostat (generally called a random positioning machine or RPM, an effective simulator of microgravity) controls and ground 1g controls. We also observed three-dimensional clinostat induced a significant increase in HRF and HR-related AtRAD54 gene expression level compared with ground 1g controls. Treatment with the ROS scavenger DMSO dramatically reduced the effects of simulated microgravity on the induction of HR and expression of the AtRAD54 gene, suggesting that ROS play a critical role in mediating the simulated microgravity mutagenic effects in plants. In order to understand the combined effects of radiation and microgravity (the main factors in space environment) on DNA damage, we further investigated the effects of modeled microgravity on radiation-induced bystander effects (RIBE) n vivo in A. thaliana plants using the expression level of the HR-related AtRAD54 gene as mutagenic end points. The results showed that the modeled microgravity significantly inhibited the up-regulated expression of the AtRAD54 gene in bystander aerial plants after root irradiation, suggesting a repressive effect of microgravity on RIBE.

  2. Torsional oscillations of a rigid disc bonded to multilayered poroelastic medium

    Institute of Scientific and Technical Information of China (English)

    WANG Guo-cai; CHEN Long-zhu

    2005-01-01

    This paper deals mainly with the dynamic response of a rigid disc bonded to the surface of a layered poroelastic half-space. The disc is subjected to time-harmonic torsional moment loadings. The half space under consideration consists of a number of layers with different thickness and material properties. Hankel transform techniques and transferring matrix method are used to solve the governing equations. The continuity of the displacement and stress fields between different layers enabled derivation of closed-form solutions in the transform domain. On the assumption that the contact between the disc and the half space is perfectly bonded, this dynamic mixed boundary-value problem can be reduced to dual integral equations, which are further reduced to Fredholm integral equations of the second kind and solved by numerical procedures. Selected numerical results for the dynamic impedance and displacement amplitude of the disc resting on different saturated models are presented to show the influence of the material and geometrical properties of both the saturated soil-foundation system and the nature of the load acting on it. The conclusions obtained can serve as guidelines for practical engineering.

  3. Evolution from protoplanetary to debris discs: The transition disc around HD 166191

    CERN Document Server

    Kennedy, G M; Lisse, C M; Ménard, F; Sitko, M L; Wyatt, M C; Bayliss, D D R; DeMeo, F E; Crawford, K B; Kim, D L; Rudy, R J; Russell, R W; Sibthorpe, B; Skinner, M A; Zhou, G

    2013-01-01

    HD 166191 has been identified by several studies as hosting a rare and extremely bright warm debris disc with an additional outer cool disc component. However, an alternative interpretation is that the star hosts a disc that is currently in transition between a full gas disc and a largely gas-free debris disc. With the help of new optical to mid-IR spectra and Herschel imaging, we argue that the latter interpretation is supported in several ways: i) we show that HD 166191 is co-moving with the ~4 Myr-old Herbig Ae star HD 163296, suggesting that the two have the same age, ii) the disc spectrum of HD 166191 is well matched by a standard radiative transfer model of a gaseous protoplanetary disc with an inner hole, and iii) the HD 166191 mid-IR silicate feature is more consistent with similarly primordial objects. We note some potential issues with the debris disc interpretation that should be considered for such extreme objects, whose lifetime at the current brightness is mush shorter than the stellar age, or i...

  4. A Simulation Model of Focus and Radial Servos in Compact Disc Players with Disc Surface Defects

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Andersen, Palle;

    2004-01-01

    Compact Disc players have been on the market in more than two decades.As a consequence most of the control servo problems have been solved. A large remaining problem to solve is the handling of Compact Discs with severe surface defects like scratches and fingerprints. This paper introduces a method...

  5. Suppression of space charge induced beam halo in nonlinear focusing channel

    Science.gov (United States)

    Batygin, Yuri K.; Scheinker, Alexander; Kurennoy, Sergey; Li, Chao

    2016-04-01

    An intense non-uniform particle beam exhibits strong emittance growth and halo formation in focusing channels due to nonlinear space charge forces of the beam. This phenomenon limits beam brightness and results in particle losses. The problem is connected with irreversible distortion of phase space volume of the beam in conventional focusing structures due to filamentation in phase space. Emittance growth is accompanied by halo formation in real space, which results in inevitable particle losses. A new approach for solving a self-consistent problem for a matched non-uniform beam in two-dimensional geometry is discussed. The resulting solution is applied to the problem of beam transport, while avoiding emittance growth and halo formation by the use of nonlinear focusing field. Conservation of a beam distribution function is demonstrated analytically and by particle-in-cell simulation for a beam with a realistic beam distribution.

  6. Stability and chaos in Kustaanheimo-Stiefel space induced by the Hopf fibration

    CERN Document Server

    Roa, Javier; Peláez, Jesús

    2016-01-01

    The need for the extra dimension in Kustaanheimo-Stiefel (KS) regularization is explained by the topology of the Hopf fibration, which defines the geometry and structure of KS space. A trajectory in Cartesian space is represented by a four-dimensional manifold, called the fundamental manifold. Based on geometric and topological aspects classical concepts of stability are translated to KS language. The separation between manifolds of solutions generalizes the concept of Lyapunov stability. The dimension-raising nature of the fibration transforms fixed points, limit cycles, attractive sets, and Poincar\\'e sections to higher-dimensional subspaces. From these concepts chaotic systems are studied. In strongly perturbed problems the numerical error can break the topological structure of KS space: points in a fiber are no longer transformed to the same point in Cartesian space. An observer in three dimensions will see orbits departing from the same initial conditions but diverging in time. This apparent randomness o...

  7. Suppression of Space Charge Induced Beam Halo in Nonlinear Focusing Channel

    CERN Document Server

    Batygin, Yuri K; Kurennoy, Sergey; Li, Chao

    2016-01-01

    An intense non-uniform particle beam exhibits strong emittance growth and halo formation in focusing channels due to nonlinear space charge forces of the beam. This phenomenon limits beam brightness and results in particle losses. The problem is connected with irreversible distortion of phase space volume of the beam in conventional focusing structures due to filamentation in phase space. Emittance growth is accompanied by halo formation in real space, which results in inevitable particle losses. A new approach for solving a self-consistent problem for a matched non-uniform beam in two-dimensional geometry is discussed. The resulting solution is applied to the problem of beam transport, while avoiding emittance growth and halo formation by the use of nonlinear focusing field. Conservation of a beam distribution function is demonstrated analytically and by particle-in-cell simulation for a beam with a realistic beam distribution.

  8. Acute pyogenic discitis in a degenerative intervertebral disc in an adult

    Directory of Open Access Journals (Sweden)

    Masamitsu Tanaka

    2010-08-01

    Full Text Available Masamitsu Tanaka1,2, Hiroshi Shimizu2, Yoshiyuki Yato1, Takashi Asazuma1, Koichi Nemoto11Department of Orthopedic Surgery, National Defense Medical College, Tokorozawa, Saitama; 2Department of Orthopedic Surgery, Self Defense Force Fukuoka Hospital, Kasuga, Fukuoka, JapanAbstract: A 35-year-old male who had been receiving conservative treatment for L4 isthmic spondylolisthesis suffered from pyogenic spondylodiscitis in the degenerative L4/L5 intervertebral disc space, which could be identified by comparison with previous images. Symptoms improved with conservative antibiotic treatment. Neovascularization may occur in the annulus fibrosus of a degenerative intervertebral disc, which may increase the risk of hematogenous infection, leading to “discitis” even in adults.Keywords: spondylodiscitis, spondylitis, discitis, isthmic spondylolisthesis, spondylolysis, intervertebral disc degeneration

  9. Solution of the H{sup +}{sub 3} model on a disc

    Energy Technology Data Exchange (ETDEWEB)

    Hosomichi, K. [CEA Saclay, Gif-sur-Yvette (France). Service de Physique Theorique; Ribault, S. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2006-10-15

    We determine all the correlators of the H{sup +}{sub 3} model on a disc with AdS{sub 2}-brane boundary conditions in terms of correlators of Liouville theory on a disc with FZZT-brane boundary conditions. We argue that the Cardy-Lewellen constraints are weaker in the H{sup +}{sub 3} model than in rational conformal field theories due to extra singularities of the correlators, but strong enough to uniquely determine the bulk two-point function on a disc. We confirm our results by detailed analyses of the bulk-boundary two-point function and of the boundary two-point function. In particular we find that, although the target space symmetry preserved by AdS{sub 2}-branes is the group SL(2,R), the open string states between two distinct parallel AdS{sub 2}-branes belong to representations of the universal covering group. (orig.)

  10. 基于瞬态分析法的轮盘制动系统摩擦自激振动研究%Study on Friction-induced Self-excited Vibration of a Wheel-disc Brake System Using Transient Analysis Method

    Institute of Scientific and Technical Information of China (English)

    黄盼盼; 陈光雄; 莫继良

    2014-01-01

    There are two analysis methodologies available for predicting brake squeal using the finite element method, namely,complex eigenvalue analysis method and dynamic transient analysis method. Not all the unstable frequency ob-tained using complex eigenvalue analysis method can be observed in experiments,while transient analysis method is able to predict real unstable frequency in theory. A transient dynamic model of a wheel-disc brake system of EMU was estab-lished to study friction-induced self-excited vibration of the brake system,in which the friction coupling between brake pads and disc was imposed. Results show that the value of the dominant vibration frequency of the contact force between the brake pad and disc is consistent with that of the normal vibration of the brake pad. The dominant vibration frequency obtained by the transient analysis method is very close to the value of the unstable frequency obtained by the complex ei-genvalue method.%在制动噪声的有限元分析方法中,复特征值方法预测得到的不稳定频率过于保守,而瞬态分析方法在理论上可以得到较为真实的不稳定频率。考虑制动闸片与制动盘接触点间的摩擦力耦合作用,基于建立的高速动车轮盘制动系统的有限元模型,采用瞬态分析法对高速动车轮盘制动系统进行摩擦自激振动分析,并与复特征值分析法得到结果的进行比较。结果表明,接触面间法向接触力的振动主频与闸片法向振动的主频一致;制动系统瞬态动力学分析得到的振动主频与其复特征值分析得到的不稳定频率基本相符。

  11. Radiation Induced Conductivity Of Space Used Polymers Under High Energy Electron Irradiation

    OpenAIRE

    Paulmier, T.; Dirassen, B.; Arnaout, M.; Payan, D.; Balcon, N.

    2014-01-01

    International audience; Polymers are widely used on spacecraft for different specific functions : thermal and electrical insulation, mechanical support, adhesion... These polymers are highly sensitive to radiation met in space. Their electric properties is especially significantly altered leading to very specific behaviour in term of charge transport and discharge processes. Different dedicated facilities have been developed at ONERA, with CNES support, for the characterisation of space used ...

  12. Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space

    DEFF Research Database (Denmark)

    Østby, Ivar; Øyehaug, Leiv; Einevoll, Gaute T;

    2009-01-01

    Neuronal stimulation causes approximately 30% shrinkage of the extracellular space (ECS) between neurons and surrounding astrocytes in grey and white matter under experimental conditions. Despite its possible implications for a proper understanding of basic aspects of potassium clearance and astr......Neuronal stimulation causes approximately 30% shrinkage of the extracellular space (ECS) between neurons and surrounding astrocytes in grey and white matter under experimental conditions. Despite its possible implications for a proper understanding of basic aspects of potassium clearance...

  13. Stem cell horizons in intervertebral disc degeneration

    Directory of Open Access Journals (Sweden)

    Joseph Ciacci

    2009-01-01

    Full Text Available Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and spine. The growing field of regenerative medicine brings the promise of stem cells in the treatment of disc disease. Scientists and physicians hope to employ stem cells not only to stop, but also reverse degeneration. However, there are many important outstanding issues, including the hostile avascular, apoptotic physiological environment of the intervertebral disc, and the difficulty of obtaining mesenchymal stem cells, and directing them towards chondrocytic differentiation and integration within the nucleus pulposus of the disc. Given the recent advances in minimally invasive spine surgery, and developing body of work on stem cell manipulation and transplantation, stem cells are uniquely poised to bring about large-scale improvements in treatment and outcomes for degenerative disc disease. In this review we will first discuss the cellular and molecular factors influencing degeneration, and then examine the efficacy and difficulties of stem cell transplantation.Keywords: intervertebral disc degeneration, stem cells, disc disease, mesenchymal stem cells, stem cell transplantation

  14. Cervical disc hernia operations through posterior laminoforaminotomy

    Directory of Open Access Journals (Sweden)

    Coskun Yolas

    2016-01-01

    Full Text Available Objective: The most common used technique for posterolateral cervical disc herniations is anterior approach. However, posterior cervical laminotoforaminomy can provide excellent results in appropriately selected patients with foraminal stenosis in either soft disc prolapse or cervical spondylosis. The purpose of this study was to present the clinical outcomes following posterior laminoforaminotomy in patients with radiculopathy. Materials and Methods: We retrospectively evaluated 35 patients diagnosed with posterolateral cervical disc herniation and cervical spondylosis with foraminal stenosis causing radiculopathy operated by the posterior cervical keyhole laminoforaminotomy between the years 2010 and 2015. Results: The file records and the radiographic images of the 35 patients were assessed retrospectively. The mean age was 46.4 years (range: 34-66 years. Of the patients, 19 were males and 16 were females. In all of the patients, the neurologic deficit observed was radiculopathy. The posterolaterally localized disc herniations and the osteophytic structures were on the left side in 18 cases and on the right in 17 cases. In 10 of the patients, the disc level was at C5-6, in 18 at C6-7, in 2 at C3-4, in 2 at C4-5, in 1 at C7-T1, in 1 patient at both C5-6 and C6-7, and in 1 at both C4-5 and C5-6. In 14 of these 35 patients, both osteophytic structures and protruded disc herniation were present. Intervertebral foramen stenosis was present in all of the patients with osteophytes. Postoperatively, in 31 patients the complaints were relieved completely and four patients had complaints of neck pain and paresthesia radiating to the arm (the success of operation was 88.5%. On control examinations, there was no finding of instability or cervical kyphosis. Conclusion: Posterior cervical laminoforaminotomy is an alternative appropriate choice in both cervical soft disc herniations and cervical stenosis.

  15. Reconstructing the star formation history of the Milky Way disc(s) from chemical abundances

    Science.gov (United States)

    Snaith, O.; Haywood, M.; Di Matteo, P.; Lehnert, M. D.; Combes, F.; Katz, D.; Gómez, A.

    2015-06-01

    We develop a chemical evolution model to study the star formation history of the Milky Way. Our model assumes that the Milky Way has formed from a closed-box-like system in the inner regions, while the outer parts of the disc have experienced some accretion. Unlike the usual procedure, we do not fix the star formation prescription (e.g. Kennicutt law) to reproduce the chemical abundance trends. Instead, we fit the abundance trends with age to recover the star formation history of the Galaxy. Our method enables us to recover the star formation history of the Milky Way in the first Gyrs with unprecedented accuracy in the inner (R 9-10 kpc) discs, as sampled in the solar vicinity. We show that half the stellar mass formed during the thick-disc phase in the inner galaxy during the first 4-5 Gyr. This phase was followed by a significant dip in star formation activity (at 8-9 Gyr) and a period of roughly constant lower-level star formation for the remaining 8 Gyr. The thick-disc phase has produced as many metals in 4 Gyr as the thin-disc phase in the remaining 8 Gyr. Our results suggest that a closed-box model is able to fit all the available constraints in the inner disc. A closed-box system is qualitatively equivalent to a regime where the accretion rate maintains a high gas fraction in the inner disc at high redshift. In these conditions the SFR is mainly governed by the high turbulence of the interstellar medium. By z ~ 1 it is possible that most of the accretion takes place in the outer disc, while the star formation activity in the inner disc is mostly sustained by the gas that is not consumed during the thick-disc phase and the continuous ejecta from earlier generations of stars. The outer disc follows a star formation history very similar to that of the inner disc, although initiated at z ~ 2, about 2 Gyr before the onset of the thin-disc formation in the inner disc.

  16. Effect of osteoporosis and intervertebral disc degeneration on endplate cartilage injury in rats

    Institute of Scientific and Technical Information of China (English)

    Lei Wang; Wei Cui; Jean Pierre Kalala; Tom Van Hoof; Bao-Ge Liu

    2014-01-01

    Objective:To investigate the effect of osteoporosis and intervertebral disc degeneration on the endplate cartilage injury in rats.Methods:A total of48 femaleSpragueDawley rats(3 months) were randomly divided intoGroupsA,B,C andD with12 rats in each group.Osteoporosis and intervertebral disc degeneration composite model, simple degeneration model and simple osteoporosis model were prepared inGroupsA,B andC respectively.After modeling, four rats of each group at12th,18th and24th week were sacrificed.Intervertebral height of cervical vertebra C6/C7 was measured.Micro-CT was used to image the endplate of cephalic and caudal cartilage atC6/C7 intervertebral disc.Abraded area rate ofC6 caudal andC7 cephalic cartilage endplate was calculated, and thenC6/C7 intervertebral disc was routinely embedded and sectioned, stained with safraninO to observe histological changes microscopically.Results:At12,18 and 24 weeks, intervertebral disc height ofC6/C7 were(0.58±0.09) mm,(0.53±0.04) mm and(0.04±0.06) mm inGroupA rats,(0.55±0.05) mm,(0.52±0.07) mm and(0.07±0.05) mm inGroupB rats.At24th week, intervertebral disc height ofGroupA rats was significantly lower than that ofGroupB rats (P0.05).At12 and18 weeks, the abraded rate ofC6 caudal andC7 cephalic cartilage endplate inGroupA rats were significantly higher than that inGroupsB,C andD rats(P0.05).Microscopic observation ofCT showed that ventral defects inC6 caudal orC7 cephalic cartilage endplate inGroupsA andB appeared after12 weeks of modeling;obvious cracks were found in front of theC6 andC7 vertebral body, and cartilage defect shown the trend of "repairing" at18 and24 weeks after modeling.Conclusions:Intervertebral disc degeneration and osteoporosis can cause damage to the cartilage endplate.Co-existence of these two factors can induce more serious damage to the endplate, which has possitive correlation with intervertebral disc degeneration.Osteoporosis plays a certain role in intervertebral disc degeneration process, and

  17. The physics of pressure variation in microchannels within corotating or static discs

    Science.gov (United States)

    Guha, Abhijit; Sengupta, Sayantan

    2016-10-01

    We formulate a comprehensive analysis for the radial pressure variation in flow through microchannels within corotating (or static) discs, which is important for its fundamental value and application potential in macrofluidic and microfluidic devices. The uniqueness and utility of the present approach emanate from our ability to describe the physics completely in terms of non-dimensional numbers and to determine quantitatively the separate roles of inertia, centrifugal force, Coriolis force, and viscous effects in the overall radial pressure difference (Δpio). It is established here that the aspect ratio (ratio of inter-disc spacing and disc radius) plays only a secondary role as an independent parameter, its major role being contained within a newly identified dynamic similarity number (Ds). For radial inflow, it is shown that the magnitude of Δpio decreases monotonically as the tangential speed ratio (γ) increases but exhibits a minima when Ds is varied. For radial outflow, it is shown that Δpio increases monotonically as the flow coefficient (ϕ) decreases but evinces a maxima when Ds is varied. It is further shown that for the radial inflow case, the minima in the magnitude of Δpio exist even when the rotational speed of the discs is reduced to zero (static discs). The demonstrated existence of these extrema (i.e., minima for radial inflow and maxima for radial outflow) creates the scope for device optimization.

  18. Stirring in massive, young debris discs from spatially resolved Herschel images

    CERN Document Server

    Moór, A; Ábrahám, P; Apai, D; Balog, Z; Grady, C; Henning, Th; Juhász, A; Kiss, Cs; Krivov, A V; Pawellek, N; Szabó, Gy M

    2014-01-01

    A significant fraction of main-sequence stars are encircled by dusty debris discs, where the short-lived dust particles are replenished through collisions between planetesimals. Most destructive collisions occur when the orbits of smaller bodies are dynamically stirred up, either by the gravitational effect of locally formed Pluto-sized planetesimals (self-stirring scenario), or via secular perturbation caused by an inner giant planet (planetary stirring). The relative importance of these scenarios in debris systems is unknown. Here we present new Herschel Space Observatory imagery of 11 discs selected from the most massive and extended known debris systems. All discs were found to be extended at far-infrared wavelengths, five of them being resolved for the first time. We evaluated the feasibility of the self-stirring scenario by comparing the measured disc sizes with the predictions of the model calculated for the ages of our targets. We concluded that the self-stirring explanation works for seven discs. How...

  19. Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc.

    Science.gov (United States)

    Hayes, Anthony J; Isaacs, Marc D; Hughes, C; Caterson, B; Ralphs, J R

    2011-10-11

    The annulus fibrosus of the intervertebral disc is a complex, radial-ply connective tissue consisting of concentric lamellae of oriented collagen. Whilst much is known of the structure of the mature annulus, less is known of how its complex collagenous architecture becomes established; an understanding of which could inform future repair/regenerative strategies. Here, using a rat disc developmental series, we describe events in the establishment of the collagenous framework of the annulus at light and electron microscopic levels and examine the involvement of class I and II small leucine rich proteoglycans (SLRPs) in the matrix assembly process. We show that a period of sustained, ordered matrix deposition follows the initial cellular differentiation/orientation phase within the foetal disc. Fibrillar matrix is deposited from recesses within the plasma membrane into compartments of interstitial space within the outer annulus - the orientation of the secreted collagen reflecting the initial cellular orientation of the laminae. Medially, we demonstrate the development of a reinforcing 'cage' of collagen fibre bundles around the foetal nucleus pulpous. This derives from the fusion of collagen bundles between presumptive end-plate and inner annulus. By birth, the distinct collagenous architectures are established and the disc undergoes considerable enlargement to maturity. We show that fibromodulin plays a prominent role in foetal development of the annulus and its attachment to vertebral bodies. With the exception of keratocan, the other SLRPs appear associated more with cartilage development within the vertebral column, but all become more prominent within the disc during its growth and differentiation.

  20. The evolution of disc galaxies with and without classical bulges since z~1

    CERN Document Server

    Sachdeva, Sonali; Saha, Kanak; Singh, Harinder P

    2015-01-01

    Establishing the relative role of internally and externally driven mechanisms responsible for disc and bulge growth is essential to understand the evolution of disc galaxies. In this context, we have studied the physical properties of disc galaxies without classical bulges in comparison to those with classical bulges since z~0.9. Using images from the Hubble Space Telescope and Sloan Digital Sky Survey, we have computed both parametric and non-parametric measures, and examined the evolution in size, concentration, stellar mass, effective stellar mass density and asymmetry. We find that both disc galaxies with and without classical bulges have gained more than 50% of their present stellar mass over the last ~8 Gyrs. Also, the increase in disc size is found to be peripheral. While the average total (Petrosian) radius almost doubles from z~0.9 to z~0, the average effective radius undergoes a marginal increase in comparison. Additionally, increase in the density of the inner region is evident through the evolutio...

  1. Anti-truncated stellar light profiles in the outer regions of STAGES spiral galaxies: bulge or disc related?

    CERN Document Server

    Maltby, David T; Gray, Meghan E; Aragón-Salamanca, Alfonso; Wolf, Christian

    2011-01-01

    We present a comparison of azimuthally averaged radial surface brightness mu(r) profiles and analytical bulge-disc decompositions (de Vaucouleurs, r^(1/4) bulge plus exponential disc) for spiral galaxies using Hubble Space Telescope/Advanced Camera for Surveys V-band imaging from the Space Telescope A901/2 Galaxy Evolution Survey (STAGES). In the established classification scheme, antitruncated mu(r) profiles (Type III) have a broken exponential disc with a shallower region beyond the break radius r_brk. The excess light at large radii (r > r_brk) can either be caused by an outer exponential disc (Type III-d) or an extended spheroidal component (Type III-s). Using our comparisons, we determine the contribution of bulge light at r > r_brk for a large sample of 78 (barred/unbarred, Sa-Sd) spiral galaxies with outer disc antitruncations (mu_brk > 24 mag arcsec^-2). In the majority of cases (~85 per cent), evidence indicates that excess light at r > r_brk is related to an outer shallow disc (Type III-d). Here, th...

  2. Functional testing of space flight induced changes in tonic motor control by using limb-attached excitation and load devices

    Science.gov (United States)

    Gallasch, Eugen; Kozlovskaya, Inessa

    2007-02-01

    Long term space flights induce atrophy and contractile changes on postural muscles such effecting tonic motor control. Functional testing of tonic motor control structures is a challenge because of the difficulties to deliver appropriate test forces on crew members. In this paper we propose two approaches for functional testing by using limb attached loading devices. The first approach is based on a frequency and amplitude controllable moving magnet exciter to deliver sinusoidal test forces during limb postures. The responding limb deflection is recorded by an embedded accelerometer to obtain limb impedance. The second approach is based on elastic limb loading to evoke self-excited oscillations during arm extensions. Here the contraction force at the oscillation onset provides information about limb stiffness. The rationale for both testing approaches is based on Feldman's λ-model. An arm expander based on the second approach was probed in a 6-month MIR space flight. The results obtained from the load oscillations, confirmed that this device is well suited to capture space flight induced neuromuscular changes.

  3. Pump laser-induced space-charge effects in HHG-driven time- and angle-resolved photoelectron spectroscopy

    Science.gov (United States)

    Oloff, L.-P.; Hanff, K.; Stange, A.; Rohde, G.; Diekmann, F.; Bauer, M.; Rossnagel, K.

    2016-06-01

    With the advent of ultrashort-pulsed extreme ultraviolet sources, such as free-electron lasers or high-harmonic-generation (HHG) sources, a new research field for photoelectron spectroscopy has opened up in terms of femtosecond time-resolved pump-probe experiments. The impact of the high peak brilliance of these novel sources on photoemission spectra, so-called vacuum space-charge effects caused by the Coulomb interaction among the photoemitted probe electrons, has been studied extensively. However, possible distortions of the energy and momentum distributions of the probe photoelectrons caused by the low photon energy pump pulse due to the nonlinear emission of electrons have not been studied in detail yet. Here, we systematically investigate these pump laser-induced space-charge effects in a HHG-based experiment for the test case of highly oriented pyrolytic graphite. Specifically, we determine how the key parameters of the pump pulse—the excitation density, wavelength, spot size, and emitted electron energy distribution—affect the measured time-dependent energy and momentum distributions of the probe photoelectrons. The results are well reproduced by a simple mean-field model, which could open a path for the correction of pump laser-induced space-charge effects and thus toward probing ultrafast electron dynamics in strongly excited materials.

  4. Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts

    Science.gov (United States)

    George, K.; Cucinotta, F. A.

    2008-01-01

    Cytogenetic analysis of astronauts blood lymphocytes provides a direct in vivo measurement of space radiation damage, which takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. We present our latest analyses of chromosome damage in astronauts blood lymphocytes assessed by fluorescence in situ hybridization (FISH) chromosome painting and collected at various times beginning directly after return from space to several years after flight. Dose was derived from frequencies of chromosome exchanges using preflight calibration curves, and the Relative Biological Effect (RBE) was estimated by comparison with individually measured physically absorbed doses. Values for average RBE were compared to the average quality factor (Q), from direct measurements of the lineal energy spectra using a tissue-equivalent proportional counter (TEPC) and radiation transport codes. Results prove that cytogenetic biodosimetry analyses on blood collected within a week or two of return from space provides a reliable estimate of equivalent radiation dose and risk after protracted exposure to space radiation of a few months or more. However, data collected several months or years after flight suggests that the yield of chromosome translocations may decline with time after the mission, indicating that retrospective doses may be more difficult to estimate. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from one crewmember, who has participated in two separate long-duration space missions and has been followed up for over 10 years, provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

  5. Experimental investigation of the stress wave propagation along a single straight chain of photo-elastic discs

    Science.gov (United States)

    Britan, Alexander M.; Glam, Beni; Igra, Ozer; Ben-Dor, Gabi

    2005-03-01

    The propagation of stress waves through a chain of discs has been studied experimentally using a high-speed photoelastic diagnostic technique and strain gauge measurements. An optically transparent single straight chain of 20-mm diameter discs, made of epoxy, was impacted in a vertical shock tube by an air shock wave. The fringe patterns of the stress field were recorded using a Q-switched YAG laser, a transmission polariscope and a CCD cameras. The incident shock wave reflected head-on from a puncher plate that was placed on top of the discs chain inducing behind it a fairly uniform step-wise pressure pulse. The duration of this pressure pulse acting over the puncher surface lasted for about 6 ms. Experiments indicated that inside the discs-chain the step-wise pressure pulse was broken into several oscillating cycles composed of transmitted and reflected stress waves that were followed by transmitted and reflected rarefaction waves. The back and forth bouncing of these waves continued until the overall stress within the discs-chain reached equilibrium with the compression force acting on the puncher plate. The stress wave propagation velocity along the discs chain was significantly lower than the appropriate speed of sound of the material from which the discs were made.

  6. A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.

    Science.gov (United States)

    Hirata, Hiroaki; Yurube, Takashi; Kakutani, Kenichiro; Maeno, Koichiro; Takada, Toru; Yamamoto, Junya; Kurakawa, Takuto; Akisue, Toshihiro; Kuroda, Ryosuke; Kurosaka, Masahiro; Nishida, Kotaro

    2014-03-01

    The intervertebral disc nucleus pulposus (NP) has two phenotypically distinct cell types-notochordal cells (NCs) and non-notochordal chondrocyte-like cells. In human discs, NCs are lost during adolescence, which is also when discs begin to show degenerative signs. However, little evidence exists regarding the link between NC disappearance and the pathogenesis of disc degeneration. To clarify this, a rat tail disc degeneration model induced by static compression at 1.3 MPa for 0, 1, or 7 days was designed and assessed for up to 56 postoperative days. Radiography, MRI, and histomorphology showed degenerative disc findings in response to the compression period. Immunofluorescence displayed that the number of DAPI-positive NP cells decreased with compression; particularly, the decrease was notable in larger, vacuolated, cytokeratin-8- and galectin-3-co-positive cells, identified as NCs. The proportion of TUNEL-positive cells, which predominantly comprised non-NCs, increased with compression. Quantitative PCR demonstrated isolated mRNA up-regulation of ADAMTS-5 in the 1-day loaded group and MMP-3 in the 7-day loaded group. Aggrecan-1 and collagen type 2α-1 mRNA levels were down-regulated in both groups. This rat tail temporary static compression model, which exhibits decreased NC phenotype, increased apoptotic cell death, and imbalanced catabolic and anabolic gene expression, reproduces different stages of intervertebral disc degeneration.

  7. Lubrication regimes in lumbar total disc arthroplasty.

    Science.gov (United States)

    Shaheen, A; Shepherd, D E T

    2007-08-01

    A number of total disc arthroplasty devices have been developed. Some concern has been expressed that wear may be a potential failure mode for these devices, as has been seen with hip arthroplasty. The aim of this paper was to investigate the lubrication regimes that occur in lumbar total disc arthroplasty devices. The disc arthroplasty was modelled as a ball-and-socket joint. Elastohydrodynamic lubrication theory was used to calculate the minimum film thickness of the fluid between the bearing surfaces. The lubrication regime was then determined for different material combinations, size of implant, and trunk velocity. Disc arthroplasties with a metal-polymer or metal-metal material combination operate with a boundary lubrication regime. A ceramic-ceramic material combination has the potential to operate with fluid-film lubrication. Disc arthroplasties with a metal-polymer or metal-metal material combination are likely to generate wear debris. In future, it is worth considering a ceramic-ceramic material combination as this is likely to reduce wear.

  8. Debris Discs: Modeling/theory review

    Science.gov (United States)

    Thébault, P.

    2012-03-01

    An impressive amount of photometric, spectroscopic and imaging observations of circumstellar debris discs has been accumulated over the past 3 decades, revealing that they come in all shapes and flavours, from young post-planet-formation systems like Beta-Pic to much older ones like Vega. What we see in these systems are small grains, which are probably only the tip of the iceberg of a vast population of larger (undetectable) collisionally-eroding bodies, leftover from the planet-formation process. Understanding the spatial structure, physical properties, origin and evolution of this dust is of crucial importance, as it is our only window into what is going on in these systems. Dust can be used as a tracer of the distribution of their collisional progenitors and of possible hidden massive pertubers, but can also allow to derive valuable information about the disc's total mass, size distribution or chemical composition. I will review the state of the art in numerical models of debris disc, and present some important issues that are explored by current modelling efforts: planet-disc interactions, link between cold (i.e. Herschel-observed) and hot discs, effect of binarity, transient versus continuous processes, etc. I will finally present some possible perspectives for the development of future models.

  9. The inner cavity of the circumnuclear disc

    CERN Document Server

    Blank, Marvin; Frank, Adam; Carroll-Nellenback, Jonathan J; Duschl, Wolfgang J

    2016-01-01

    The circumnuclear disc (CND) orbiting the Galaxy's central black hole is a reservoir of material that can ultimately provide energy through accretion, or form stars in the presence of the black hole, as evidenced by the stellar cluster that is presently located at the CND's centre. In this paper, we report the results of a computational study of the dynamics of the CND. The results lead us to question two paradigms that are prevalent in previous research on the Galactic Centre. The first is that the disc's inner cavity is maintained by the interaction of the central stellar cluster's strong winds with the disc's inner rim, and second, that the presence of unstable clumps in the disc implies that the CND is a transient feature. Our simulations show that, in the absence of a magnetic field, the interaction of the wind with the inner disc rim actually leads to a filling of the inner cavity within a few orbital time-scales, contrary to previous expectations. However, including the effects of magnetic fields stabi...

  10. Crystallization of Self-Propelled Hard Discs

    Science.gov (United States)

    Briand, G.; Dauchot, O.

    2016-08-01

    We experimentally study the crystallization of a monolayer of vibrated discs with a built-in polar asymmetry, a model system of active liquids, and contrast it with that of vibrated isotropic discs. Increasing the packing fraction ϕ , the quasicontinuous crystallization reported for isotropic discs is replaced by a transition, or a crossover, towards a "self-melting" crystal. Starting from the liquid phase and increasing the packing fraction, clusters of dense hexagonal-ordered packed discs spontaneously form, melt, split, and merge, leading to a highly intermittent and heterogeneous dynamics. For a packing fraction larger than ϕ*, a few large clusters span the system size. The cluster size distribution is monotonically decreasing for ϕ ϕ*, and is a power law at the transition. The system is, however, never dynamically arrested. The clusters permanently melt from place to place, forming droplets of an active liquid which rapidly propagate across the system. This self-melting crystalline state subsists up to the highest possible packing fraction, questioning the stability of the crystal for active discs unless it is at ordered close packing.

  11. The quiescent phase of galactic disc growth

    CERN Document Server

    Aumer, Michael; Schönrich, Ralph

    2016-01-01

    We perform a series of controlled N-body simulations of growing disc galaxies within non-growing, live dark matter haloes of varying mass and concentration. Our initial conditions include either a low-mass disc or a compact bulge. New stellar particles are continuously added on near-circular orbits to the existing disc, so spiral structure is continuously excited. To study the effect of combined spiral and giant molecular cloud (GMC) heating on the discs we introduce massive, short-lived particles that sample a GMC mass function. An isothermal gas component is introduced for a subset of the models. We perform a resolution study and vary parameters governing the GMC population, the histories of star formation and radial scale growth. Models with GMCs and standard values for the disc mass and halo density provide the right level of self-gravity to explain the age velocity dispersion relation of the Solar neighbourhood (Snhd). GMC heating generates remarkably exponential vertical profiles with scaleheights that ...

  12. Control of lattice spacing in a triangular lattice of feeble magnetic particles formed by induced magnetic dipole interactions

    Directory of Open Access Journals (Sweden)

    Noriyuki Hirota, Tsutomu Ando, Ryo Tanaka, Hitoshi Wada and Yoshio Sakka

    2009-01-01

    Full Text Available We studied methods of controlling the spacing between particles in the triangular lattice formed by feeble magnetic particles through induced magnetic dipole interaction. Formation of a triangular lattice is described by the balance between the magnetic force and the interaction of induced magnetic dipoles. The intensity of the magnetic force is proportional to the volume of particles V and the difference in the magnetic susceptibilities between the particles and the surrounding medium Δχ. On the other hand, the intensity of the induced magnetic dipole interaction depends on the square of V and Δχ. Therefore, altering the magnetic susceptibility difference by changing the susceptibility of the surrounding medium, volume of the particles, and intensity and spatial distribution of the applied magnetic field effectively controls the distance between the particles. In this study, these three methods were evaluated through experiment and molecular dynamics simulations. The distance between the particles, i.e. the lattice constant of the triangular lattice, was varied from 1.7 to 4.0 in units of the particle diameter. Formation of self-organized triangular lattice through the induced magnetic dipole interaction is based on magnetism, a physical property that all materials have. Therefore, this phenomenon is applicable to any materials of any size. Consequently, structure formation through induced magnetic dipole interaction is a potential way of fabricating materials with ordered structures.

  13. Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates.

    Science.gov (United States)

    Sanoh, Seigo; Santoh, Masataka; Takagi, Masashi; Kanayama, Tatsuya; Sugihara, Kazumi; Kotake, Yaichiro; Ejiri, Yoko; Horie, Toru; Kitamura, Shigeyuki; Ohta, Shigeru

    2014-09-01

    Hepatotoxicity induced by the metabolic activation of drugs is a major concern in drug discovery and development. Three-dimensional (3-D) cultures of hepatocyte spheroids may be superior to monolayer cultures for evaluating drug metabolism and toxicity because hepatocytes in spheroids maintain the expression of various metabolizing enzymes and transporters, such as cytochrome P450 (CYP). In this study, we examined the hepatotoxicity due to metabolic activation of acetaminophen (APAP) using fluorescent indicators of cell viability and intracellular levels of glutathione (GSH) in rat hepatocyte spheroids grown on micro-space cell culture plates. The mRNA expression levels of some drug-metabolizing enzymes were maintained during culture. Additionally, this culture system was compatible with microfluorometric imaging under confocal laser scanning microscopy. APAP induced a decrease in intracellular ATP at 10mM, which was blocked by the CYP inhibitor 1-aminobenzotriazole (ABT). APAP (10mM, 24h) decreased the levels of both intracellular ATP and GSH, and GSH-conjugated APAP (APAP-GSH) were formed. All three effects were blocked by ABT, confirming a contribution of APAP metabolic activation by CYP to spheroid toxicity. Fluorometric imaging of hepatocyte spheroids on micro-space cell culture plates may allow the screening of drug-induced hepatotoxicity during pharmaceutical development.

  14. Effect of amygdalin on end-plate chondrocytes apoptosis induced by IL-1βderived from rat intervertebral discs%苦杏仁苷对 IL-1β诱导后大鼠椎间盘软骨终板细胞凋亡的影响

    Institute of Scientific and Technical Information of China (English)

    郑为超; 牛凯; 赵永见; 张雷; 王拥军

    2014-01-01

    目的:观察不同浓度的苦杏仁苷对 IL-1β诱导的大鼠椎间盘软骨终板细胞凋亡的影响,并进一步探讨其作用的可能机制。方法从1月龄 SD 大鼠椎间盘中分离软骨终板并培养,经鉴定后,随机分为正常组、诱导组、苦杏仁苷10-2、10-3、10-4、10-5 mol·L -1给药组,采用流式细胞仪检测大鼠椎间盘软骨终板细胞的凋亡,Real-time PCR (RT-PCR)检测凋亡相关基因的表达情况,Western blot 检测细胞内 Bax、Bcl-2蛋白的表达。结果不同浓度的苦杏仁苷能够拮抗 IL-1β诱导的大鼠椎间盘软骨终板细胞凋亡。流式分析显示各浓度的苦杏仁苷可以降低 IL-1β诱导的大鼠椎间盘软骨终板细胞的凋亡比例;RT-PCR 结果提示苦杏仁苷各浓度组可拮抗 IL-1β上调 Bax mRNA 的表达,下调 Bcl-2 mRNA 的表达,各组与诱导组相比较,其差异具有统计学意义(P <0.05);Western blot 检测结果显示苦杏仁苷10-4 mol·L -1给药组能够拮抗 IL-1β上调 Bax 蛋白的表达,下调 Bcl-2蛋白的表达。结论苦杏仁苷能够拮抗 IL-1β诱导大鼠椎间盘软骨终板细胞的凋亡,起到延缓椎间盘退变的作用。%Aim To observe the anti-apoptotic effect of different concentrations of amygdalin on the endplate chondrocytes induced by IL-1 βderived from rat inter-vertebral discs and explore the possible mechanism fur-ther.Methods Chondrocytes were obtained from endplate of one-month SD rat intervertebral discs and cultured primary chondrocytes.After identifying,they were divided into normal group,induced group and A-mygdalin 1 0 -2 mol·L -1 ,1 0 -3 mol·L -1 ,1 0 -4 mol· L -1 ,1 0 -5 mol · L -1 administration group.Then the apoptosis was detected by flow cytometry (FCM).Re-al-Time PCR was adopted to detect the mRNA expres-sion of Bax and Bcl-2.The protein expression of Bax and Bcl-2 was detected by Western blot.Results The apoptosis of the endplate

  15. Collision velocity of dust grains in self-gravitating protoplanetary discs

    CERN Document Server

    Booth, Richard A

    2016-01-01

    We have conducted the first comprehensive numerical investigation of the relative velocity distribution of dust particles in self-gravitating protoplanetary discs with a view to assessing the viability of planetesimal formation via direct collapse in such environments. The viability depends crucially on the large sizes that are preferentially collected in pressure maxima produced by transient spiral features (Stokes numbers, $St \\sim 1$); growth to these size scales requires that collision velocities remain low enough that grain growth is not reversed by fragmentation. We show that, for a single sized dust population, velocity driving by the disc's gravitational perturbations is only effective for $St > 3$, while coupling to the gas velocity dominates otherwise. We develop a criterion for understanding this result in terms of the stopping distance being of order the disc scale height. Nevertheless, the relative velocities induced by differential radial drift in multi-sized dust populations are too high to all...

  16. Three-dimensional simulations of multiple protoplanets embedded in a protostellar disc

    CERN Document Server

    Cresswell, Paul; 10.1051/0004-6361:20079178

    2008-01-01

    Protoplanet eccentricities of e >~ H/r can slow or reverse migration, but previous 2D studies have shown that gravitational scattering cannot maintain significant planet eccentricities against disc-induced damping. We simulate the evolution of low-mass protoplanetary swarms in three dimensions. The aim is to examine both protoplanet survival rates and the dynamical structure of the resulting planetary systems, and to compare them with 2D simulations. We present results from a 3D hydrodynamic simulation of eight protoplanets embedded in a protoplanetary disc. We also present a suite of simulations performed using an N-body code, modified to include prescriptions for planetary migration and for eccentricity and inclination damping. These prescriptions were obtained by fitting analytic formulae to hydrodynamic simulations of planets embedded in discs with initially eccentric and/or inclined orbits. As was found in two dimensions, differential migration produces groups of protoplanets in stable, multiple mean-mot...

  17. Warps and waves in the stellar discs of the Auriga cosmological simulations

    Science.gov (United States)

    Gómez, Facundo A.; White, Simon D. M.; Grand, Robert J. J.; Marinacci, Federico; Springel, Volker; Pakmor, Rüdiger

    2017-03-01

    Recent studies have revealed an oscillating asymmetry in the vertical structure of the Milky Way's disc. Here, we analyse 16 high-resolution, fully cosmological simulations of the evolution of individual Milky Way-sized galaxies, carried out with the magnetohydrodynamic code AREPO. At redshift zero, about 70 per cent of our galactic discs show strong vertical patterns, with amplitudes that can exceed 2 kpc. Half of these are typical 'integral sign' warps. The rest are oscillations similar to those observed in the Milky Way. Such structures are thus expected to be common. The associated mean vertical motions can be as large as 30 km s-1. Cold disc gas typically follows the vertical patterns seen in the stars. These perturbations have a variety of causes: close encounters with satellites, distant fly-bys of massive objects, accretion of misaligned cold gas from halo infall or from mergers. Tidally induced vertical patterns can be identified in both young and old stellar populations, whereas those originating from cold gas accretion are seen mainly in the younger populations. Galaxies with regular or at most weakly perturbed discs are usually, but not always, free from recent interactions with massive companions, although we have one case where an equilibrium compact disc reforms after a merger.

  18. Close stellar encounters with planetesimal discs The dynamics of asymmetry in the Beta Pictoris system

    CERN Document Server

    Larwood, J D

    2000-01-01

    We numerically investigate the dynamics of how a close stellar fly-by encounter of a symmetrical circumstellar planetesimal disc can give rise to the many kinds of asymmetries and substructures attributed to the edge-on dusty disc of Beta Pic. In addition we present new optical coronagraphic observations of the outer parts of Beta Pic's disc, and report that the radial extent is significantly greater than was found in previous measurements. The northeasterly extension of the disc's midplane is now measured out to 1835au from the star; the southwesterly component is measured out to 1450au. Hence we use the length asymmetry induced in a distribution of simulation test particles as the principal diagnostic feature when modelling the disc response, in order to constrain fly-by parameters. In particular we favour a low inclination prograde and near-parabolic orbit perturber of mass approximately 0.5 Solar masses. These initial conditions suggest that the perturber could have been physically associated with Beta Pi...

  19. Lumbar disc herniation in a patient with congenital vertebral body anomaly: a case report.

    Science.gov (United States)

    Atabey, Cem; Eroğlu, Ahmet; Topuz, Ali Kivanc; Velioğlu, Murat; Demircan, Mehmet Nusret

    2014-12-01

    Lumbar disc herniation is characterized with low back and leg pain resulting from the degenerated lumbar disc compressing the spinal nerve root. The etiology of degenerative spine is related to age, smoking, microtrauma, obesity, disorders of familial collagen structure, occupational and sports-related physical activity. However, disc herniations induced by congenital lumbar vertebral anomalies are rarely seen. Vertebral fusion defect is one of the causes of congenital anomalies. The pathogenesis of embryological corpus vertebral fusion anomaly is not fully known. In this paper, a 30-year-old patient who had the complaints of low back and right leg pain after falling from a height is presented. She had right L5-S1 disc herniation that had developed on the basis of S1 vertebra corpus fusion anomaly in Lumbar computed tomography. This case has been discussed in the light of literature based on evaluations of Lumbar Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This case is unique in that it is the first case with development of lumbar disc herniation associated with S1 vertebral corpus fusion anomaly. Congenital malformations with unusual clinical presentation after trauma should be evaluated through advanced radiological imaging techniques.

  20. Off-centred dark matter halo leading to strong central disc lopsidedness

    CERN Document Server

    Prasad, Chaitanya

    2016-01-01

    There is increasing evidence now from simulations and observations that the centre of dark matter halo in a Milky Way type galaxy could be off-centred by a few 100 pc w.r.t. the galactic disc. We study the effect of such an offset halo on the orbits and kinematics in the central few kpc of the disc. The equations of motion in the disc plane can be written in terms of the disc and halo potentials when these two are concentric and a perturbation term due to the offset halo. This perturbation potential shows an m=1 azimuthal variation, or is lopsided, and its magnitude increases at small radii. On solving these equations, we find that the perturbed orbit shows a large deviation of ~ 40 % in radius at R = 1.5 kpc, and also strong kinematical lopsidedness. Thus even a small halo offset of 350 pc can induce surprisingly strong spatial and kinematical lopsidedness in the central region within ~ 3 kpc radius. Further, the disc would remain lopsided for several Gyr, as long as the halo offset lasts. This would have im...

  1. OPTIC DISC MELANOCYTOMA: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sahiba Bedi

    2016-08-01

    Full Text Available Melanocytoma of the optic disc is a rare ophthalmic tumour that arises from melanocytes and is a variant of the melanocytic nevus. It occurs on the optic disc and often extends into the peripapillary retina and choroid. It appears as a dark brown or black lesion, typically small and is almost always unilateral. Although traditionally believed to be a relatively stationary lesion, it is now known to exhibit minor enlargement in 10–15% of cases and can cause minor visual loss by a variety of mechanisms. 1-2% cases can transform to malignant melanoma. We present a case report of a 65-year-old female whose dilated fundus examination of the right eye revealed a circular, pigmented and elevated lesion about 1.5 mm in size covering almost whole of the optic nerve head except for the superior rim, suggestive of optic disc melanocytoma.

  2. Signatures of massive collisions in debris discs

    CERN Document Server

    Kral, Quentin; Augereau, Jean-Charles; Boccaletti, Anthony; Charnoz, Sebastien

    2014-01-01

    Violent stochastic collisional events have been invoked as a possible explanation for some debris discs displaying pronounced asymmetries or having a great luminosity excess. So far, no thorough modelling of the consequences of such events has been carried out, mainly because of the extreme numerical challenge of coupling the dynamical and collisional evolution of dust. We perform the first fully self-consistent modelling of the aftermath of massive breakups in debris discs. We follow the collisional and dynamical evolution of dust released after the breakup of a Ceres-sized body at 6 AU from its central star. We investigate the duration, magnitude and spatial structure of the signature left by such a violent event, as well as its observational detectability. We use the recently developed LIDT-DD code (Kral et al., 2013), which handles the coupled collisional and dynamical evolution of debris discs. The main focus is placed on the complex interplay between destructive collisions, Keplerian dynamics and radiat...

  3. Black hole feedback from thick accretion discs

    CERN Document Server

    Sadowski, Aleksander; Abramowicz, Marek A; Narayan, Ramesh

    2015-01-01

    We study energy flows in geometrically thick accretion discs, both optically thick and thin, using general relativistic, three-dimensional simulations of black hole accretion flows. We find that for non-rotating black holes the efficiency of the total feedback from thick accretion discs is $3\\%$ - roughly half of the thin disc efficiency. This amount of energy is ultimately distributed between outflow and radiation, the latter scaling weakly with the accretion rate for super-critical accretion rates, and returned to the interstellar medium. Accretion on to rotating black holes is more efficient because of the additional extraction of rotational energy. However, the jet component is collimated and likely to interact only weakly with the environment, whereas the outflow and radiation components cover a wide solid angle.

  4. Satellites in discs regulating the accretion luminosity

    CERN Document Server

    Syer, D; Syer, Dave; Clarke, Cathie

    1995-01-01

    We demonstrate, using a simple analytic model, that the presence of a massive satellite can globally modify the structure and emission properties of an accretion disc to which it is tidally coupled. We show, using two levels of numerical approximation, that the analytic model gives reasonable results. The results are applicable to two astrophysical situations. In the case of an active galactic nucleus, we consider the case of a \\sim 10^3\\Msun compact companion to the central black-hole and show that it could modulate the emitted spectrum on a timescale of \\sim10^5 years. In the case of a T Tauri accretion disc, a satellite such as a sub-dwarf or giant planet could modify the disc spectral energy distribution over a substantial fraction of the T Tauri star lifetime.

  5. The debris disc around HIP 17439

    Science.gov (United States)

    Schüppler, Christian; Löhne, Torsten; Krivov, Alexander

    2013-07-01

    In the framework of the Herschel Open Time Key Programme DUNES the debris disc around the K2 V star HIP 17439 was observed. In PACS images the disc emission is spatially clearly extended. A simultaneous analysis of photometric observations and radial brightness profiles from the resolved images provides valuable hints for the disc structure. In an analytical model we adopted power laws for the size and radial distribution of the circumstellar dust and tested two different scenarios: (1) a broad dust ring with a radial extent of about 200AU, (2) two independent dust rings separated by a gap of several tens of AU. Both models fit the spectral energy distribution and the radial profiles quite well. In case (1) the parameters found are consistent with dust stemming from an outer planetesimal belt at ~140AU and strong transport mechanisms that drag the particles inward. Model (2) would imply two planetesimal belts, producing a narrow inner and wider outer distribution of dust.

  6. Effects of disc midplane evolution on CO snowline location

    Science.gov (United States)

    Panić, O.; Min, M.

    2017-01-01

    Temperature changes in the planet forming disc midplanes carry important physico-chemical consequences, such as the effect on the locations of the condensation fronts of molecules - the snowlines. Snowlines impose major chemical gradients and possibly foster grain growth. The aim of this paper is to understand how disc midplane temperature changes with gas and dust evolution, and identify trends that may influence planet formation or allow to constrain disc evolution observationally. We calculate disc temperature, hydrostatic equilibrium and dust settling in a mutually consistent way from a grid of disc models at different stages of gas loss, grain growth and hole opening. We find that the CO snowline location depends very strongly on disc properties. The CO snowline location migrates closer to the star for increasing degrees of gas dispersal and dust growth. Around a typical A type star, the snowline can be anywhere between several tens and a few hundred au, depending on the disc properties such as gas mass and grain size. In fact, gas loss is as efficient as dust evolution in settling discs, and flat discs may be gas-poor counterparts of flared discs. Our results, in the context of different pre-main sequence evolution of the luminosity in low- and intermediate-mass stars suggests very different thermal (and hence chemical) histories in these two types of discs. Discs of T Tauri stars settle and cool down while discs of Herbig Ae stars may remain rather warm throughout the pre-main sequence.

  7. Adjusted NIEL calculations for estimating proton-induced degradation of GaInP/GaAs/Ge space solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Lu Ming [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Wang Rong, E-mail: wangr@bnu.edu.cn [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China); Liu Yunhong [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China); Hu Wentao [Tianjin Institute of Power Sources, Tianjin 300381 (China); Feng Zhao; Han Zhaolei [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875 (China)

    2011-09-01

    The non-ionizing energy loss (NIEL) values for protons in solar cells should be modified by taking into account the distribution of the Bragg damage peak in the active region to calculate the corresponding displacement damage dose. In this paper, based upon a thin target approximation, a new approach is presented to modify NIEL values for protons on a GaAs sub-cell. Adjusted NIEL values can be used to estimate the degradation induced by protons on GaInP/GaAs/Ge triple-junction space solar cells.

  8. A Study of Cosmic Ray Secondaries Induced by the Mir Space Station Using AMS-01

    CERN Document Server

    Aguilar, M A; Allaby, James V; Alpat, B; Ambrosi, G; Anderhub, H; Ao, L; Arefev, A; Azzarello, P; Babucci, E; Baldini, L; Basile, M; Barancourt, D; Barão, F; Barbier, G; Barreira, G; Battiston, R; Becker, R; Becker, U; Bellagamba, L; Bene, P; Berdugo, J; Berges, P; Bertucci, B; Biland, A; Bizzaglia, S; Blasko, S; Bölla, G; Boschini, M; Bourquin, Maurice; Brocco, L; Bruni, G; Buénerd, M; Burger, J D; Burger, W J; Cai, X D; Camps, C; Cannarsa, P; Capell, M; Carosi, G; Casadei, D; Casaus, J; Castellini, G; Cecchi, C; Chang, Y H; Chen, H F; Chen, H S; Chen, Z G; Chernoplekov, N A; Tzi Hong Chiueh; Cho, K; Choi, M J; Choi, Y Y; Chuang, Y L; Cindolo, F; Commichau, V; Contin, A; Cortina, E; Cristinziani, M; Da Cunha, J P; Dai, T S; Delgado, C; Demirkoz, B; Deus, J D; Dinu, N; Djambazov, L; D'Antone, I; Dong, Z R; Emonet, P; Engelberg, J; Eppling, F J; Eronen, T; Esposito, G; Extermann, P; Favier, Jean; Fiandrini, E; Fisher, P H; Flügge, G; Fouque, N; Galaktionov, Yu; Gervasi, M; Giusti, P; Grandi, D; Grimm, O; Gu, W Q; Hangarter, K; Hasan, A; Henning, R; Hermel, V; Hofer, H; Huang, M A; Hungerford, W; Ionica, M; Ionica, R; Jongmanns, M; Karlamaa, K; Karpinski, W; Kenney, G; Kenny, J; Kim, D H; Kim, G N; Kim, K S; Kim, M Y; Klimentov, A; Kossakowski, R; Koutsenko, V F; Kraeber, M; Laborie, G; Laitinen, T; Lamanna, G; Lanciotti, E; Laurenti, G; Lebedev, A; Lechanoine-Leluc, C; Lee, M W; Lee, S C; Levi, G; Levchenko, P M; Liu, C L; Liu, H T; Lopes, I; Lu, G; Lü, Y S; Lübelsmeyer, K; Luckey, D; Lustermann, W; Maña, C; Margotti, A; Mayet, F; McNeil, R R; Meillon, B; Menichelli, M; Mihul, A; Monreal, B; Mourao, A; Mujunen, A; Palmonari, F; Papi, A; Park, H B; Park, W H; Pauluzzi, M; Pauss, Felicitas; Perrin, E; Pesci, A; Pevsner, A; Pimenta, M; Plyaskin, V; Pozhidaev, V; Pohl, M; Postolache, V; Rancoita, P G; Rapin, D; Raupach, F; Ren, D; Ren, Z; Ribordy, M; Richeux, J P; Riihonen, E; Ritakari, J; Ro, S; Röser, U; Rossin, C; Sagdeev, R; Santos, D; Sartorelli, G; Sbarra, C; Schael, S; Schultzvon Dratzig, A; Schwering, G; Scolieri, G; Seo, E S; Shin, J W; Shoumilov, E; Shoutko, V; Siedling, R; Son, D; Song, T; Steuer, M; Sun, G S; Suter, H; Tang, X W; Ting, Samuel C C; Ting, S M; Tornikoski, M; Torsti, J; Trumper, J; Ulbricht, J; Urpo, S; Valtonen, E; Vandenhirtz, J; Velcea, F; Velikhov, E P; Verlaat, B; Vetlitskii, I; Vezzu, F; Vialle, J P; Viertel, Gert M; Vitè, Davide F; Von Gunten, H P; Waldmeier-Wicki, S; Wallraff, W; Wang, B C; Wang, J Z; Wang, Y H; Wiik, K; Williams, C; Wu, S X; Xia, P C; Yan, J L; Yan, L G; Yang, C G; Yang, J; Yang, M; Ye, S W; Yeh, P; Xu, Z Z; Zhang, H Y; Zhang, Z P; Zhao, D X; Zhu, G Y; Zhu, W Z; Zhuang, H L; Zichichi, A; Zimmermann, B; Zuccon, P

    2004-01-01

    The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics experiment that will study cosmic rays in the $\\sim 100 \\mathrm{MeV}$ to $1 \\mathrm{TeV}$ range and will be installed on the International Space Station (ISS) for at least 3 years. A first version of AMS-02, AMS-01, flew aboard the space shuttle \\emph{Discovery} from June 2 to June 12, 1998, and collected $10^8$ cosmic ray triggers. Part of the \\emph{Mir} space station was within the AMS-01 field of view during the four day \\emph{Mir} docking phase of this flight. We have reconstructed an image of this part of the \\emph{Mir} space station using secondary $\\pi^-$ and $\\mu^-$ emissions from primary cosmic rays interacting with \\emph{Mir}. This is the first time this reconstruction was performed in AMS-01, and it is important for understanding potential backgrounds during the 3 year AMS-02 mission.

  9. Effect of continuous lumbar traction on the size of herniated disc material in lumbar disc herniation.

    Science.gov (United States)

    Ozturk, Bulent; Gunduz, Osman Hakan; Ozoran, Kursat; Bostanoglu, Sevinc

    2006-05-01

    We investigated the effects of continuous lumbar traction in patients with lumbar disc herniation on clinical findings, and size of the herniated disc measured by computed tomography (CT). In this prospective, randomized, controlled study, 46 patients with lumbar disc herniation were included, and randomized into two groups as the traction group (24 patients), and the control group (22 patients). The traction group was given a physical therapy program and continuous lumbar traction. The control group was given the same physical therapy program without traction, for the same duration of time. Data for the clinical symptoms and signs were collected before and after the treatment together with calculation of a herniation index, from the CT images that showed the size of the herniated disc material. In the traction group, most of the clinical findings significantly improved with treatment. Size of the herniated disc material in CT decreased significantly only in the traction group. In the traction group the herniation index decreased from 276.6+/-129.6 to 212.5+/-84.3 with treatment (p0.05). Patients with greater herniations tended to respond better to traction. In conclusion, lumbar traction is both effective in improving symptoms and clinical findings in patients with lumbar disc herniation and also in decreasing the size of the herniated disc material as measured by CT.

  10. Cometary ices in forming protoplanetary disc midplanes

    Science.gov (United States)

    Drozdovskaya, Maria N.; Walsh, Catherine; van Dishoeck, Ewine F.; Furuya, Kenji; Marboeuf, Ulysse; Thiabaud, Amaury; Harsono, Daniel; Visser, Ruud

    2016-10-01

    Low-mass protostars are the extrasolar analogues of the natal Solar system. Sophisticated physicochemical models are used to simulate the formation of two protoplanetary discs from the initial prestellar phase, one dominated by viscous spreading and the other by pure infall. The results show that the volatile prestellar fingerprint is modified by the chemistry en route into the disc. This holds relatively independent of initial abundances and chemical parameters: physical conditions are more important. The amount of CO2 increases via the grain-surface reaction of OH with CO, which is enhanced by photodissociation of H2O ice. Complex organic molecules are produced during transport through the envelope at the expense of CH3OH ice. Their abundances can be comparable to that of methanol ice (few per cent of water ice) at large disc radii (R > 30 au). Current Class II disc models may be underestimating the complex organic content. Planet population synthesis models may underestimate the amount of CO2 and overestimate CH3OH ices in planetesimals by disregarding chemical processing between the cloud and disc phases. The overall C/O and C/N ratios differ between the gas and solid phases. The two ice ratios show little variation beyond the inner 10 au and both are nearly solar in the case of pure infall, but both are subsolar when viscous spreading dominates. Chemistry in the protostellar envelope en route to the protoplanetary disc sets the initial volatile and prebiotically significant content of icy planetesimals and cometary bodies. Comets are thus potentially reflecting the provenances of the midplane ices in the solar nebula.

  11. Stability and chaos in Kustaanheimo-Stiefel space induced by the Hopf fibration

    Science.gov (United States)

    Roa, Javier; Urrutxua, Hodei; Peláez, Jesús

    2016-07-01

    The need for the extra dimension in Kustaanheimo-Stiefel (KS) regularization is explained by the topology of the Hopf fibration, which defines the geometry and structure of KS space. A trajectory in Cartesian space is represented by a four-dimensional manifold called the fundamental manifold. Based on geometric and topological aspects classical concepts of stability are translated to KS language. The separation between manifolds of solutions generalizes the concept of Lyapunov stability. The dimension-raising nature of the fibration transforms fixed points, limit cycles, attractive sets, and Poincaré sections to higher dimensional subspaces. From these concepts chaotic systems are studied. In strongly perturbed problems, the numerical error can break the topological structure of KS space: points in a fibre are no longer transformed to the same point in Cartesian space. An observer in three dimensions will see orbits departing from the same initial conditions but diverging in time. This apparent randomness of the integration can only be understood in four dimensions. The concept of topological stability results in a simple method for estimating the time-scale in which numerical simulations can be trusted. Ideally, all trajectories departing from the same fibre should be KS transformed to a unique trajectory in three-dimensional space, because the fundamental manifold that they constitute is unique. By monitoring how trajectories departing from one fibre separate from the fundamental manifold a critical time, equivalent to the Lyapunov time, is estimated. These concepts are tested on N-body examples: the Pythagorean problem, and an example of field stars interacting with a binary.

  12. Age Induced Effects on ESD Characteristics of Solar Array Coupons After Combined Space Environmental Exposures

    Science.gov (United States)

    Wright, Kenneth H.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Funderburk, Victor V.; Wong, Frankie; Gardiner, George

    2012-01-01

    A set of multi-junction GaAs/Ge solar array test coupons provided by Space Systems/Loral were subjected to a sequence of 5-year increments of combined space environment exposure tests. The test coupons capture an integrated design intended for use in a geosynchronous (GEO) space environment. A key component of this test campaign is performing electrostatic discharge (ESD) tests in the inverted gradient mode. The protocol of the ESD tests is based on the ISO standard for ESD testing on solar array panels [ISO-11221]. The test schematic in the ISO reference has been modified with Space System/Loral designed circuitry to better simulate the on-orbit operational conditions of its solar array design. Part of the modified circuitry is to simulate a solar array panel coverglass flashover discharge. All solar array coupons used in the test campaign consist of four cells constructed to form two strings. The ESD tests were performed at the beginning-of-life (BOL) and at each 5-year environment exposure point until end-of-life (EOL) at 15 years. The space environmental exposure sequence consisted of ultra-violet radiation, electron/proton particle radiation, thermal cycling, and Xenon ion thruster plume erosion. This paper describes the ESD test setup and the importance of the electrical test design in simulating the on-orbit operational conditions. Arc inception voltage results along with ESD test behavior from the BOL condition through the 15th year age condition are discussed. In addition, results from a Xenon plasma plume exposure test with an EOL coupon under the full ESD test condition will be discussed.

  13. Laser induced breakdown spectroscopy for elemental analysis in environmental, cultural heritage and space applications: a review of methods and results.

    Science.gov (United States)

    Gaudiuso, Rosalba; Dell'Aglio, Marcella; De Pascale, Olga; Senesi, Giorgio S; De Giacomo, Alessandro

    2010-01-01

    Analytical applications of Laser Induced Breakdown Spectroscopy (LIBS), namely optical emission spectroscopy of laser-induced plasmas, have been constantly growing thanks to its intrinsic conceptual simplicity and versatility. Qualitative and quantitative analysis can be performed by LIBS both by drawing calibration lines and by using calibration-free methods and some of its features, so as fast multi-elemental response, micro-destructiveness, instrumentation portability, have rendered it particularly suitable for analytical applications in the field of environmental science, space exploration and cultural heritage. This review reports and discusses LIBS achievements in these areas and results obtained for soils and aqueous samples, meteorites and terrestrial samples simulating extraterrestrial planets, and cultural heritage samples, including buildings and objects of various kinds.

  14. Laser Induced Breakdown Spectroscopy for Elemental Analysis in Environmental, Cultural Heritage and Space Applications: A Review of Methods and Results

    Directory of Open Access Journals (Sweden)

    Alessandro De Giacomo

    2010-08-01

    Full Text Available Analytical applications of Laser Induced Breakdown Spectroscopy (LIBS, namely optical emission spectroscopy of laser-induced plasmas, have been constantly growing thanks to its intrinsic conceptual simplicity and versatility. Qualitative and quantitative analysis can be performed by LIBS both by drawing calibration lines and by using calibration-free methods and some of its features, so as fast multi-elemental response, micro-destructiveness, instrumentation portability, have rendered it particularly suitable for analytical applications in the field of environmental science, space exploration and cultural heritage. This review reports and discusses LIBS achievements in these areas and results obtained for soils and aqueous samples, meteorites and terrestrial samples simulating extraterrestrial planets, and cultural heritage samples, including buildings and objects of various kinds.

  15. Gene Expression Profile Changes and Cellular Responses to Bleomycin-Induced DNA Damage in Human Fibroblast Cells in Space

    Science.gov (United States)

    Lu, Tao; Zhang, Ye; Kidane, Yared; Feiveson, Alan; Stodieck, Louis; Karouia, Fathi; Rohde, Larry; Wu, Honglu

    2016-01-01

    Living organisms are constantly exposed to space radiation that consists of energetic protons and other heavier charged particles. In addition, DNA in space can be damaged by toxic chemicals or reactive oxygen species generated due to increased levels of environmental and psychological stresses. Understanding the impact of spaceflight factors, microgravity in particular, on cellular responses to DNA damage affects the accuracy of the radiation risk assessment for astronauts and the mutation rate in microorganisms. Although possible synergistic effects of space radiation and microgravity have been investigated since the early days of the human space program, the published results were mostly conflicting and inconsistent. To investigate the effects of spaceflight on cellular responses to DNA damage, confluent human fibroblast cells (AG1522) flown on the International Space Station (ISS) were treated with bleomycin for three hours in the true microgravity environment, which induced DNA damages including double-strand breaks (DSB). Damages in the DNA were quantified by immunofluorescence staining for ?-H2AX, which showed similar percentages of different types of stained cells between flight and ground. However, there was a slight shift in the distribution of the ?-H2AX foci number in the flown cells with countable foci. Comparison of the cells in confluent and in exponential growth conditions indicated that the proliferation rate between flight and the ground may be responsible for such a shift. A microarray analysis of gene expressions in response to bleomycin treatment was also performed. Comparison of the responsive pathways between the flown and ground cells showed similar responses with the p53 network being the top upstream regulator. Similar responses at the RNA level between different gravity conditions were also observed with a PCR array analysis containing a set of genes involved in DNA damage signaling; with BBC3, CDKN1A, PCNA and PPM1D being significantly

  16. Dual joint space arthrography in temporomandibular joint disorders: Comparison with single inferior joint space arthrography

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hyung Sik; Chang, Duk Soo; Lee, Kyung Soo; Kim, Woo Sun; Sung, Jung Ho; Jun, Young Hwan [Capital Armed Forces General Hospital, Seoul (Korea, Republic of)

    1989-02-15

    The temporomandibular joint(TMJ) is really a complex of two synovial space separated by fibrocartilaginous disc. Single inferior joint space arthrography is commonly performed for evaluation of TMJ disorders, which is known to be superior in demonstrating joint dynamics. But it reveals only the inferior surface of the disc. Therefore, dual space arthrography is superior to demonstrate the soft tissue anatomic feature of the joint such as disc position and shape. Authors performed 83 TMJ arthrograms in TMJ problems. Initially, the inferior joint space was done and then the superior space was sequentially contrasted. The follow results were noted: 1. In all cases, dual space arthrography revealed accurate disc shape and positions. 2. Concordant findings between the two techniques: 68 cases (82%). Discordance between the two techniques: 15 cases (18%) 3. Possible causes of discordance between inferior and dual space arthrography. a) Normal varians of anterior recess: 3 cases b) Posterior disc displacement: 4 cases c) Influence of the patient's head position change :4 cases d) False perforation: 2 cases e) Reduction change: 2 cases 4. In 5 cases with anterior displacement, dual space arthrography gave additional findings such as adhesion within the superior space, which could not be evaluated by single inferior space.

  17. Cells and Biomaterials for Intervertebral Disc Regeneration

    CERN Document Server

    Grad, Sibylle

    2010-01-01

    Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in th

  18. Natural course of lumber disc herniation

    Energy Technology Data Exchange (ETDEWEB)

    Tokioka, Takamitsu; Shimada, Kimio; Tanaka, Yuzo; Oshige, Toshihisa; Miyakoshi, Koichi [Okayama Rosai Hospital (Japan)

    1998-09-01

    Thirty-two cases of lumbar disc herniation were sequentially followed by MR imagings in order to ascertain its natural course. Herniation consisted of protrusion in 6 cases, extrusion in 13 cases, and sequestration in 13 cases. We analysed the durations until the herniation regressed more than 50% of its A-P diameter. The mean duration was 8.2 months for extrusion, and 5.3 months for sequestration. Only 2 cases of protrusion regressed within 12 months. Huge disc herniations with central protrusion in particular showed slight spontaneous regression. (author)

  19. Disc-Capped ZnO Nanocombs

    Institute of Scientific and Technical Information of China (English)

    LI Xin; XU chun-xiang; ZHU Guang-Ping; YANG Yi; LIU Jin-Ping; SUN Xiao-Wei; CUI Yi-Ping

    2007-01-01

    Nanocombs with a disc cap structure of ZnO have been synthesized on si substrates by using pure Zinc powders as the source materials based on a vapour-phase transport process.The morphology and the microstructure are investigated by a scanning electron microscopy and x-ray diffraction.Based on the transmission electron microscopy and selected area electron diffraction analysis,the growth directions of three representative parts,nanoribbon stem,nanorod branch and nanodisc cap of the nanocomb are revealed.The growth mechanism of the disc-capped nanocombs is discussed based on the self-catalyzed vapour-liquid-solid process.

  20. Rare complications of osteolysis and periprosthetic tissue reactions after hybrid and non-hybrid total disc replacement.

    Science.gov (United States)

    Veruva, Sai Y; Lanman, Todd H; Hanzlik, Josa A; Kurtz, Steven M; Steinbeck, Marla J

    2015-05-01

    Few complications have been reported for lumbar total disc replacement (TDR) and hybrid TDR fixations. This study evaluated retrieved implants and periprosthetic tissue reactions for two cases of osteolysis following disc arthroplasty with ProDisc-L prostheses. Implants were examined for wear and surface damage, and tissues for inflammation, polyethylene wear debris (polarized light microscopy) and metal debris (energy-dispersive X-ray spectroscopy). Despite initial good surgical outcomes, osteolytic cysts were noted in both patients at vertebrae adjacent to the implants. For the hybrid TDR case, heterotopic ossification and tissue necrosis due to wear-induced inflammation were observed. In contrast, the non-hybrid implant showed signs of abrasion and impingement, and inflammation was observed in tissue regions with metal and polyethylene wear debris. In both cases, wear debris and inflammation may have contributed to osteolysis. Surgeons using ProDisc prostheses should be aware of these rare complications.