Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

Directory of Open Access Journals (Sweden)

Anjar Priyono

2016-11-01

develop an index of factors affecting disassembly, and how to most appropriate relationship between original equipment manufacturers and contract remanufacturers to share knowledge gained from remanufacturing operations to improve product remanufacturability. Practical implications: Remanufacturers should not focus on product attributes only in order to manage their disassembly process efficiently. Rather, more strategic factors such organisational factors and process choices should also be considered as well. Originality/value: This is the first study that identifies a comprehensive factors affecting disassembly in remanufacturing. In addition, it is for the first time that disassembly is not only viewed as a physical activity, but it is a process that consists of a series of step.

Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

International Nuclear Information System (INIS)

Priyono, A.; Ijomah, W.; Bititci, U.

2016-01-01

factors affecting disassembly, and how to most appropriate relationship between original equipment manufacturers and contract remanufacturers to share knowledge gained from remanufacturing operations to improve product remanufacturability. Practical implications: Remanufacturers should not focus on product attributes only in order to manage their disassembly process efficiently. Rather, more strategic factors such organisational factors and process choices should also be considered as well. Originality/value: This is the first study that identifies a comprehensive factors affecting disassembly in remanufacturing. In addition, it is for the first time that disassembly is not only viewed as a physical activity, but it is a process that consists of a series of step.

Disassembly for remanufacturing: A systematic literature review, new model development and future research needs

Energy Technology Data Exchange (ETDEWEB)

Priyono, A.; Ijomah, W.; Bititci, U.

2016-07-01

factors affecting disassembly, and how to most appropriate relationship between original equipment manufacturers and contract remanufacturers to share knowledge gained from remanufacturing operations to improve product remanufacturability. Practical implications: Remanufacturers should not focus on product attributes only in order to manage their disassembly process efficiently. Rather, more strategic factors such organisational factors and process choices should also be considered as well. Originality/value: This is the first study that identifies a comprehensive factors affecting disassembly in remanufacturing. In addition, it is for the first time that disassembly is not only viewed as a physical activity, but it is a process that consists of a series of step.

Disassembly and Sanitization of Classified Matter

International Nuclear Information System (INIS)

Stockham, Dwight J.; Saad, Max P.

2008-01-01

, Pantex personnel have asked the DSO team to assist them with the destruction of their stored classified components. The DSO process is in full-scale operation and continues to grow and serve SNL/NM and DOE by providing a solution to this evolving disposal issue. For some time, SNL has incurred significant expenses for the management and storage of classified components. This project is estimated to save DOE and Sandia several hundreds of thousands of dollars while the excess inventory is eliminated. This innovative approach eliminates the need for long-term storage of classified weapons components and the associated monitoring and accounting expenditures

Multi-kanban mechanism for appliance disassembly

Science.gov (United States)

Udomsawat, Gun; Gupta, Surendra M.

2005-11-01

The use of household appliances continues to rise every year. A significant number of End-Of-Life (EOL) appliances are generated because of the introduction of newer models that are more attractive, efficient and affordable. Others are, of course, generated when they become non-functional. Many regulations encourage recycling of EOL appliances to reduce the amount of waste sent to landfills. In addition, EOL appliances offer the appliance manufacturing and remanufacturing industries a source of less expensive raw materials and components. For this reason product recovery has become a subject of interest during the past decade. In this paper, we study the disassembly line for appliance disassembly. We discuss and incorporate some of the complications that are inherent in disassembly line including product arrival, demand arrival, inventory fluctuation and production control mechanisms. We show how to overcome such complications by implementing a multi-kanban system in the appliance disassembly line setting. The multi-kanban system (MKS) relies on dynamic routing of kanbans according to the state of the system. We investigate the multi-kanban mechanism using simulation and explore the effect of product mix on performance of the traditional push system (TPS) and MKS in terms of controlling the system's inventory while attempting to achieve a decent customer service level.

Shape memory polymer nanocomposites for application of multiple-field active disassembly: experiment and simulation.

Science.gov (United States)

Carrell, John; Zhang, Hong-Chao; Wang, Shiren; Tate, Derrick

2013-11-19

Active disassembly (AD) uses innovative materials that can perform a designed disassembly action by the application of an external field. AD provides improvements over current disassembly processes by limiting machine or manual labor and enabling batch processing for end-of-life products. With improved disassembly operations, more reuse of components and purer recycling streams may be seen. One problem with AD, however, has been with the single-field actuation because of the probability of accidental disassembly. This presentation will discuss the application of shape memory polymer (SMP) nanocomposites in a new AD process. This novel AD process requires multiple-field actuation of the SMP nanocomposite fastener. In the analysis of this AD process, thermal and magnetic field tests were performed on the SMP nanocomposite. From these tests, finite-element analysis was performed to model and simulate the multiple-field AD process. The results of the simulations provide performance variables for the AD process and show a better performance time for the SMP nanocomposite fastener than for a comparable SMP fastener.

Methods for otpimum and near optimum disassembly sequencing

NARCIS (Netherlands)

Lambert, A.J.D.; Gupta, S.M.

2008-01-01

This paper considers disassembly sequencing problems subjected to sequence dependent disassembly costs. In practice, the methods for dealing with such problems rely mainly on metaheuristic and heuristic methods, which intrinsically generate suboptimum solutions. Exact methods are NP-hard and

Pit disassembly and conversion demonstration environmental assessment and research and development activities

International Nuclear Information System (INIS)

1998-08-01

A significant portion of the surplus plutonium is in the form of pits, a nuclear weapons component. Pits are composed of plutonium which is sealed in a metallic shell. These pits would need to be safely disassembled and permanently converted to an unclassified form that would be suitable for long-term disposition and international inspection. To determine the feasibility of an integrated pit disassembly and conversion system, a Pit Disassembly and Conversion Demonstration is proposed to take place at the Los Alamos National Laboratory (LANL). This demonstration would be done in existing buildings and facilities, and would involve the disassembly of up to 250 pits and conversion of the recovered plutonium to plutonium metal ingots and plutonium dioxide. This demonstration also includes the conversion of up to 80 kilograms of clean plutonium metal to plutonium dioxide because, as part of the disposition process, some surplus plutonium metal may be converted to plutonium dioxide in the same facility as the surplus pits. The equipment to be used for the proposed demonstration addressed in this EA would use some parts of the Advanced Recovery and Integrated Extraction System (ARIES) capability, other existing equipment/capacities, plus new equipment that was developed at other sites. In addition, small-scale R and D activities are currently underway as part of the overall surplus plutonium disposition program. These R and D activities are related to pit disassembly and conversion, MOX fuel fabrication, and immobilization (in glass and ceramic forms). They are described in Section 7.0. On May 16, 1997, the Office of Fissile Materials Disposition (MD) notified potentially affected states and tribes that this EA would be prepared in accordance with NEPA. This EA has been prepared to provide sufficient information for DOE to determine whether a Finding of No Significant Impact (FONSI) is warranted or whether an EIS must be prepared

Mathematical and Simulation Modelling of Moisture Diffusion Mechanism during Plastic IC Packages Disassembly

Directory of Open Access Journals (Sweden)

Peng Mou

2013-01-01

Full Text Available Reuse of plastic IC packages disassembled from printed circuit boards (PCBs has significant environmental benefits and economic value. The interface delamination caused by moisture diffusion is the main failure mode of IC packages during the disassembling process, which greatly reduces the reusability and reliability of disassembled IC packages. Exploring moisture diffusion mechanism is a prerequisite to optimize prebaking processes before disassembling that is an effective way to avoid the interface delamination. To this end, a computational model with variable boundary conditions is developed based on the different combination state of water in IC packages. The distribution characteristics and mechanism of moisture diffusion behavior are analyzed including the humidity distribution field and the relation among baking temperature, water loss rate, and baking time during baking process, and then the results are validated by FEA simulation based on the improved definition of relative moisture concentration. Baking under variable temperature is proposed and compared with the baking process and baking efficiency under constant temperature to find out the optimized baking parameters. Finally, a set of curves which indicate the relation between baking energy consumption and temperature are determined under actual industrial baking experiments, which could be used as references to develop industrial standards for PCB disassembling process.

An Intelligent Agent-Controlled and Robot-Based Disassembly Assistant

Science.gov (United States)

Jungbluth, Jan; Gerke, Wolfgang; Plapper, Peter

2017-09-01

One key for successful and fluent human-robot-collaboration in disassembly processes is equipping the robot system with higher autonomy and intelligence. In this paper, we present an informed software agent that controls the robot behavior to form an intelligent robot assistant for disassembly purposes. While the disassembly process first depends on the product structure, we inform the agent using a generic approach through product models. The product model is then transformed to a directed graph and used to build, share and define a coarse disassembly plan. To refine the workflow, we formulate “the problem of loosening a connection and the distribution of the work” as a search problem. The created detailed plan consists of a sequence of actions that are used to call, parametrize and execute robot programs for the fulfillment of the assistance. The aim of this research is to equip robot systems with knowledge and skills to allow them to be autonomous in the performance of their assistance to finally improve the ergonomics of disassembly workstations.

Nuclear fuel bundle disassembly and assembly tool

International Nuclear Information System (INIS)

Yates, J.; Long, J.W.

1975-01-01

A nuclear power reactor fuel bundle is described which has a plurality of tubular fuel rods disposed in parallel array between two transverse tie plates. It is secured against disassembly by one or more locking forks which engage slots in tie rods which position the transverse plates. Springs mounted on the fuel and tie rods are compressed when the bundle is assembled thereby maintaining a continual pressure against the locking forks. Force applied in opposition to the springs permits withdrawal of the locking forks so that one tie plate may be removed, giving access to the fuel rods. An assembly and disassembly tool facilitates removal of the locking forks when the bundle is to be disassembled and the placing of the forks during assembly of the bundle. (U.S.)

Design and analysis of sustainable computer mouse using design for disassembly methodology

Science.gov (United States)

Roni Sahroni, Taufik; Fitri Sukarman, Ahmad; Agung Mahardini, Karunia

2017-12-01

This paper presents the design and analysis of computer mouse using Design for Disassembly methodology. Basically, the existing computer mouse model consist a number of unnecessary part that cause the assembly and disassembly time in production. The objective of this project is to design a new computer mouse based on Design for Disassembly (DFD) methodology. The main methodology of this paper was proposed from sketch generation, concept selection, and concept scoring. Based on the design screening, design concept B was selected for further analysis. New design of computer mouse is proposed using fastening system. Furthermore, three materials of ABS, Polycarbonate, and PE high density were prepared to determine the environmental impact category. Sustainable analysis was conducted using software SolidWorks. As a result, PE High Density gives the lowers amount in the environmental category with great maximum stress value.

Balancing Disassembly Line in Product Recovery to Promote the Coordinated Development of Economy and Environment

Directory of Open Access Journals (Sweden)

Jia Liu

2017-02-01

Full Text Available For environmentally conscious and sustainable manufacturing, many more manufacturers are acting to recycle and remanufacture their post-consumed products. The most critical process of remanufacturing is disassembly, since it allows for the selective extraction of the valuable components and materials from returned products to reduce the waste disposal volume. It is, therefore, important to design and balance the disassembly line to work efficiently due to its vital role in effective resource usage and environmental protection. Considering the disassembly precedence relationships and sequence-dependent parts removal time increments, this paper presents an improved discrete artificial bee colony algorithm (DABC for solving the sequence-dependent disassembly line balancing problem (SDDLBP. The performance of the proposed algorithm was tested against nine other approaches. Computational results evidently indicate the superior efficiency of the proposed algorithm for addressing the environmental and economic concerns while optimizing the multi-objective SDDLBP.

Studies of fast reactor disassembly using a Bethe-Tait computer code

International Nuclear Information System (INIS)

Ludwig, J.C.

1978-10-01

The advantages of the fast reactor are given and the general design outlined. Loss of Flow and Transient Overpower faults are possible; the potential consequences of such incidents are analysed using a deterministic approach. The course of an incident is split into several stages; of these only predisassembly and disassembly are considered. Predisassembly computer codes are described in general, and several particular codes are examined in more detail, based on a literature survey. The results and implications of disassembly calculations using the code EXTRA are presented. Here, the effects of several factors, such as the presence of retained fission gases and possible restraints on fuel motion, are investigated. Some comparisons are made with published results from the VENUS-II disassembly code. A general conclusion is that under some circumstances, the yield predicted during disassembly is relatively insensitive to modelling assumptions, and a simple code such as EXTRA may prove adequate if explicit core displacements are not required. A major factor in determining the yield of the disassembly phase is confirmed as being the rate of reactivity insertion during disassembly, as predicted by a predisassembly code. (U.K.)

Illustrating the disassembly of 3D models

KAUST Repository

Guo, Jianwei

2013-06-11

We present a framework for the automatic disassembly of 3D man-made models and the illustration of the disassembly process. Given an assembled 3D model, we first analyze the individual parts using sharp edge loops and extract the contact faces between each pair of neighboring parts. The contact faces are then used to compute the possible moving directions of each part. We then present a simple algorithm for clustering the sets of the individual parts into meaningful sub-assemblies, which can be used for a hierarchical decomposition. We take the stability of sub-assemblies into account during the decomposition process by considering the upright orientation of the input models. Our framework also provides a user-friendly interface to enable the superimposition of the constraints for the decomposition. Finally, we visualize the disassembly process by generating an animated sequence. The experiments demonstrate that our framework works well for a variety of complex models. © 2013 Elsevier Ltd.

Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly.

Science.gov (United States)

Davies, Brian A; Azmi, Ishara F; Payne, Johanna; Shestakova, Anna; Horazdovsky, Bruce F; Babst, Markus; Katzmann, David J

2010-10-01

ESCRT-III undergoes dynamic assembly and disassembly to facilitate membrane exvagination processes including multivesicular body (MVB) formation, enveloped virus budding, and membrane abscission during cytokinesis. The AAA-ATPase Vps4 is required for ESCRT-III disassembly, however the coordination of Vps4 ATP hydrolysis with ESCRT-III binding and disassembly is not understood. Vps4 ATP hydrolysis has been proposed to execute ESCRT-III disassembly as either a stable oligomer or an unstable oligomer whose dissociation drives ESCRT-III disassembly. An in vitro ESCRT-III disassembly assay was developed to analyze Vps4 function during this process. The studies presented here support a model in which Vps4 acts as a stable oligomer during ATP hydrolysis and ESCRT-III disassembly. Moreover, Vps4 oligomer binding to ESCRT-III induces coordination of ATP hydrolysis at the level of individual Vps4 subunits. These results suggest that Vps4 functions as a stable oligomer that acts upon individual ESCRT-III subunits to facilitate ESCRT-III disassembly.

Mathematical and Simulation Modelling of Moisture Diffusion Mechanism during Plastic IC Packages Disassembly

OpenAIRE

Peng Mou; Dong Xiang; Guanghong Duan

2013-01-01

Reuse of plastic IC packages disassembled from printed circuit boards (PCBs) has significant environmental benefits and economic value. The interface delamination caused by moisture diffusion is the main failure mode of IC packages during the disassembling process, which greatly reduces the reusability and reliability of disassembled IC packages. Exploring moisture diffusion mechanism is a prerequisite to optimize prebaking processes before disassembling that is an effective way to avoid the ...

Disassembly of JT-60 tokamak device and ancillary facilities for JT-60 tokamak

International Nuclear Information System (INIS)

Okano, Fuminori; Ichige, Hisashi; Miyo, Yasuhiko; Kaminaga, Atsushi; Sasajima, Tadayuki; Nishiyama, Tomokazu; Yagyu, Jun-ichi; Ishige, Youichi; Suzuki, Hiroaki; Komuro, Kenichi; Sakasai, Akira; Ikeda, Yoshitaka

2014-03-01

The disassembly of JT-60 tokamak device and its peripheral equipments, where the total weight was about 5400 tons, started in 2009 and accomplished in October 2012. This disassembly was required process for JT-60SA project, which is the Satellite Tokamak project under Japan-EU international corroboration to modify the JT-60 to the superconducting tokamak. This work was the first experience of disassembling a large radioactive fusion device based on Radiation Hazard Prevention Act in Japan. The cutting was one of the main problems in this disassembly, such as to cut the welded parts together with toroidal field coils, and to cut the vacuum vessel into two. After solving these problems, the disassembly completed without disaster and accident. This report presents the outline of the JT-60 disassembly, especially tokamak device and ancillary facilities for tokamak device. (author)

Desmosome Assembly and Disassembly Are Membrane Raft-Dependent

Science.gov (United States)

Faundez, Victor; Koval, Michael; Mattheyses, Alexa L.; Kowalczyk, Andrew P.

2014-01-01

Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament cytoskeleton. Alterations in assembly and disassembly compromise desmosome function and may contribute to human diseases, such as the autoimmune skin blistering disease pemphigus vulgaris (PV). We previously demonstrated that PV auto-antibodies directed against the desmosomal cadherin desmoglein 3 (Dsg3) cause loss of adhesion by triggering membrane raft-mediated Dsg3 endocytosis. We hypothesized that raft membrane microdomains play a broader role in desmosome homeostasis by regulating the dynamics of desmosome assembly and disassembly. In human keratinocytes, Dsg3 is raft associated as determined by biochemical and super resolution immunofluorescence microscopy methods. Cholesterol depletion, which disrupts rafts, prevented desmosome assembly and adhesion, thus functionally linking rafts to desmosome formation. Interestingly, Dsg3 did not associate with rafts in cells lacking desmosomal proteins. Additionally, PV IgG-induced desmosome disassembly occurred by redistribution of Dsg3 into raft-containing endocytic membrane domains, resulting in cholesterol-dependent loss of adhesion. These findings demonstrate that membrane rafts are required for desmosome assembly and disassembly dynamics, suggesting therapeutic potential for raft targeting agents in desmosomal diseases such as PV. PMID:24498201

Multi-kanban mechanism for personal computer disassembly

Science.gov (United States)

Udomsawat, Gun; Gupta, Surendra M.; Kamarthi, Sagar V.

2004-12-01

The use of personal computers (PCs) continues to increase every year. According to a 1999 figure, 50 percent of all US households owned PCs, a figure that continues to rise every year. With continuous development of sophisticated software, PCs are becoming increasingly powerful. In addition, the price of a PC continues to steadily decline. Furthermore, the typical life of a PC in the workplace is approximately two to three years while in the home it is three to five years. As these PCs become obsolete, they are replaced and the old PCs are disposed of. It is estimated that between 14 and 20 million PCs are retired annually in the US. While 20 to 30% of the units may be resold, the others are discarded. These discards represent a significant potential source of lead for the waste stream. In some communities, waste cathode ray tubes (CRTs) represent the second largest source of lead in the waste stream after vehicular lead acid batteries. PCs are, therefore, not suitable for dumping in landfills. Besides, several components of a PC can be reused and then there are other valuable materials that can also be harvested. And with the advent of product stewardship, product recovery is the best solution for manufacturers. Disassembly line is perhaps the most suitable set up for disassembling PCs. However, planning and scheduling of disassembly on a disassembly line is complicated. In this paper, we discuss some of the complications including product arrival, demand arrival, inventory fluctuation and production control mechanisms. We then show how to overcome them by implementing a multi-kanban mechanism in the PC disassembly line setting. The multi-kanban mechanism relies on dynamic routing of kanbans according to the state of the system. We investigate the multi-kanban mechanism using simulation and demonstrate that this mechanism is superior to the traditional push system in terms of controlling the system"s inventory while maintaining a decent customer service level.

On the optimal design of the disassembly and recovery processes.

Science.gov (United States)

Xanthopoulos, A; Iakovou, E

2009-05-01

This paper tackles the problem of the optimal design of the recovery processes of the end-of-life (EOL) electric and electronic products, with a special focus on the disassembly issues. The objective is to recover as much ecological and economic value as possible, and to reduce the overall produced quantities of waste. In this context, a medium-range tactical problem is defined and a novel two-phased algorithm is presented for a remanufacturing-driven reverse supply chain. In the first phase, we propose a multicriteria/goal-programming analysis for the identification and the optimal selection of the most 'desirable' subassemblies and components to be disassembled for recovery, from a set of different types of EOL products. In the second phase, a multi-product, multi-period mixed-integer linear programming (MILP) model is presented, which addresses the optimization of the recovery processes, while taking into account explicitly the lead times of the disassembly and recovery processes. Moreover, a simulation-based solution approach is proposed for capturing the uncertainties in reverse logistics. The overall approach leads to an easy-to-use methodology that could support effectively middle level management decisions. Finally, the applicability of the developed methodology is illustrated by its application on a specific case study.

On the optimal design of the disassembly and recovery processes

International Nuclear Information System (INIS)

Xanthopoulos, A.; Iakovou, E.

2009-01-01

This paper tackles the problem of the optimal design of the recovery processes of the end-of-life (EOL) electric and electronic products, with a special focus on the disassembly issues. The objective is to recover as much ecological and economic value as possible, and to reduce the overall produced quantities of waste. In this context, a medium-range tactical problem is defined and a novel two-phased algorithm is presented for a remanufacturing-driven reverse supply chain. In the first phase, we propose a multicriteria/goal-programming analysis for the identification and the optimal selection of the most 'desirable' subassemblies and components to be disassembled for recovery, from a set of different types of EOL products. In the second phase, a multi-product, multi-period mixed-integer linear programming (MILP) model is presented, which addresses the optimization of the recovery processes, while taking into account explicitly the lead times of the disassembly and recovery processes. Moreover, a simulation-based solution approach is proposed for capturing the uncertainties in reverse logistics. The overall approach leads to an easy-to-use methodology that could support effectively middle level management decisions. Finally, the applicability of the developed methodology is illustrated by its application on a specific case study

Accomplishment of JT-60U disassembly work dealing with radioactive components

International Nuclear Information System (INIS)

Ikeda, Yoshitaka

2015-01-01

The upgrade of the JT-60U to the superconducting tokamak 'JT-60SA' has been carried out to contribute the early realization of fusion energy by addressing key physics issues relevant for ITER and DEMO. Disassembly of the JT-60U tokamak was required so as to newly install the JT-60SA torus at the same position in the torus hall. The JT-60U tokamak was featured by the complicated and welded structure against the strong electromagnetic force, and by the radioactivation due to deuterium-deuterium (D-D) reactions of 1.5x10"2"0 (n) in total. Since this work was the first experience of disassembling a large radioactivated fusion device in Japan, careful preparations of disassembly activities, including treatment of the radioactivated materials and safety work, have been made. About 13,000 components with a total weight of more than 5,400 tonnes were removed from the torus hall and stored safely in storage facilities. All disassembly components were stored with recording the data such as dose rate, weight and kind of material, so as to apply the clearance level regulation in future. It was confirmed that the main radioactive material of the disassembly components was the stainless steel and that its dose rate was almost background level (∼0.1 μSv/h) at ∼10 m far from the vacuum vessel. It seems that the disassembly components with background dose level are in the clearance level. The assembly of JT-60SA tokamak has started in January 2013 after this disassembly of the JT-60U tokamak. (author)

An Entropy-Based Adaptive Hybrid Particle Swarm Optimization for Disassembly Line Balancing Problems

Directory of Open Access Journals (Sweden)

Shanli Xiao

2017-11-01

Full Text Available In order to improve the product disassembly efficiency, the disassembly line balancing problem (DLBP is transformed into a problem of searching for the optimum path in the directed and weighted graph by constructing the disassembly hierarchy information graph (DHIG. Then, combining the characteristic of the disassembly sequence, an entropy-based adaptive hybrid particle swarm optimization algorithm (AHPSO is presented. In this algorithm, entropy is introduced to measure the changing tendency of population diversity, and the dimension learning, crossover and mutation operator are used to increase the probability of producing feasible disassembly solutions (FDS. Performance of the proposed methodology is tested on the primary problem instances available in the literature, and the results are compared with other evolutionary algorithms. The results show that the proposed algorithm is efficient to solve the complex DLBP.

A methodological approach for designing and sequencing product families in Reconfigurable Disassembly Systems

Directory of Open Access Journals (Sweden)

Ignacio Eguia

2011-10-01

Full Text Available Purpose: A Reconfigurable Disassembly System (RDS represents a new paradigm of automated disassembly system that uses reconfigurable manufacturing technology for fast adaptation to changes in the quantity and mix of products to disassemble. This paper deals with a methodology for designing and sequencing product families in RDS. Design/methodology/approach: The methodology is developed in a two-phase approach, where products are first grouped into families and then families are sequenced through the RDS, computing the required machines and modules configuration for each family. Products are grouped into families based on their common features using a Hierarchical Clustering Algorithm. The optimal sequence of the product families is calculated using a Mixed-Integer Linear Programming model minimizing reconfigurability and operational costs. Findings: This paper is focused to enable reconfigurable manufacturing technologies to attain some degree of adaptability during disassembly automation design using modular machine tools. Research limitations/implications: The MILP model proposed for the second phase is similar to the well-known Travelling Salesman Problem (TSP and therefore its complexity grows exponentially with the number of products to disassemble. In real-world problems, which a higher number of products, it may be advisable to solve the model approximately with heuristics. Practical implications: The importance of industrial recycling and remanufacturing is growing due to increasing environmental and economic pressures. Disassembly is an important part of remanufacturing systems for reuse and recycling purposes. Automatic disassembly techniques have a growing number of applications in the area of electronics, aerospace, construction and industrial equipment. In this paper, a design and scheduling approach is proposed to apply in this area. Originality/value: This paper presents a new concept called Reconfigurable Disassembly System

Design for Disassembly

DEFF Research Database (Denmark)

Beim, Anne

2018-01-01

‘Design for Disassembly’ is becoming a familiar part of discourses on environmental strategies for construction and sustainable design. The concept originates in industrial design and pertains to a wide range of strategies for reuse and recycling, all of which highlight a whole-of-life approach t...... to materials and buildings. Design for Disassembly is particularly relevant to prefabricated and industrialized construction; as such methodologies already contain within them the possibility for easy deconstruction, whether for maintenance, refurbishment or reuse....

Application of industrial robots in automatic disassembly line of waste LCD displays

Science.gov (United States)

Wang, Sujuan

2017-11-01

In the automatic disassembly line of waste LCD displays, LCD displays are disassembled into plastic shells, metal shields, circuit boards, and LCD panels. Two industrial robots are used to cut metal shields and remove circuit boards in this automatic disassembly line. The functions of these two industrial robots, and the solutions to the critical issues of model selection, the interfaces with PLCs and the workflows were described in detail in this paper.

Cleaning, disassembly, and requalification of the FFTF in vessel handling machine

International Nuclear Information System (INIS)

Coops, W.J.

1977-10-01

The Engineering Model In Vessel Handling Machine (IVHM) was successfully removed, cleaned, disassembled, inspected, reassembled and reinstalled into the sodium test vessel at Richland, Washington. This was the first time in the United States a full size operational sodium wetted machine has been cleaned by the water vapor nitrogen process and requalified for operation. The work utilized an atmospheric control system during removal, a tank type water vapor nitrogen cleaning system and an open ''hands on'' disassembly and assembly stand. Results of the work indicate the tools, process and equipment are adequate for the non-radioactive maintenance sequence. Additionally, the work proves that a machine of this complexity can be successfully cleaned, maintained and re-used without the need to replace a large percentage of the sodium wetted parts

Low cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus

Energy Technology Data Exchange (ETDEWEB)

Soonthornsit, Jeerawat [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Yamaguchi, Yoko; Tamura, Daisuke [Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192 (Japan); Ishida, Ryuichi; Nakakoji, Yoko; Osako, Shiho [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Yamamoto, Akitsugu [Department of Animal Bioscience, Nagahama Institute of Bio-Science and Technology, 266 Tamura, Nagahama, Shiga, 526‐0829 (Japan); Nakamura, Nobuhiro, E-mail: osaru3@cc.kyoto-su.ac.jp [Laboratory for Cell and Developmental Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555 (Japan); Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192 (Japan)

2014-11-01

The Golgi apparatus was dramatically disassembled when cells were incubated in a low pH medium. The cis-Golgi disassembled quickly, extended tubules and spread to the periphery of cells within 30 min. In contrast, medial- and trans-Golgi were fragmented in significantly larger structures of smaller numbers at a slower rate and remained largely in structures distinct from the cis-Golgi. Electron microscopy revealed the complete disassembly of the Golgi stack in low pH treated cells. The effect of low pH was reversible; the Golgi apparatus reassembled to form a normal ribbon-like structure within 1–2 h after the addition of a control medium. The anterograde ER to Golgi transport and retrograde Golgi to ER transport were both reduced under low pH. Phospholipase A{sub 2} inhibitors (ONO, BEL) effectively suppressed the Golgi disassembly, suggesting that the phospholipase A{sub 2} was involved in the Golgi disassembly. Over-expression of Rab1, 2, 30, 33 and 41 also suppressed the Golgi disassembly under low pH, suggesting that they have protective role against Golgi disassembly. Low pH treatment reduced cytoplasmic pH, but not the luminal pH of the Golgi apparatus, strongly suggesting that reduction of the cytoplasmic pH triggered the Golgi disassembly. Because a lower cytoplasmic pH is induced in physiological or pathological conditions, disassembly of the Golgi apparatus and reduction of vesicular transport through the Golgi apparatus may play important roles in cell physiology and pathology. Furthermore, our findings indicated that low pH treatment can serve as an important tool to analyze the molecular mechanisms that support the structure and function of the Golgi apparatus. - Highlights: • The Golgi apparatus reversibly disassembles by low pH treatment. • The cis-Golgi disassembles quickly generating tubular structures. • Both anterograde and retrograde transport between the ER and the Golgi apparatus are reduced. • Phospholipase A{sub 2} inhibitors (ONO

Development of remote disassembly technology for liquid-metal reactor (LMR) fuel

International Nuclear Information System (INIS)

Bradley, E.C.; Evans, J.H.; Metz, C.F. III; Weil, B.S.

1990-01-01

A major objective of the Consolidated Fuel Reprocessing Program (CFRP) is to develop equipment and demonstrate technology to reprocess fast breeder reactor fuel. Experimental work on fuel disassembly cutting methods began in the 1970s. High-power laser cutting was selected as the preferred cutting method for fuel disassembly. Remotely operated development equipment was designed, fabricated, installed, and tested at Oak Ridge National Laboratory (ORNL). Development testing included remote automatic operation, remote maintenance testing, and laser cutting process development. This paper summarizes the development work performed at ORNL on remote fuel disassembly. 2 refs., 1 fig

Disassembly Properties of Cementitious Finish Joints Using an Induction Heating Method

Science.gov (United States)

Ahn, Jaecheol; Noguchi, Takafumi; Kitagaki, Ryoma

2015-01-01

Efficient maintenance and upgrading of a building during its lifecycle are difficult because a cementitious finish uses materials and parts with low disassembly properties. Additionally, the reuse and recycling processes during building demolition also present numerous problems from the perspective of environmental technology. In this study, an induction heating (IH) method was used to disassemble cementitious finish joints, which are widely used to join building members and materials. The IH rapidly and selectively heated and weakened these joints. The temperature elevation characteristics of the cementitious joint materials were measured as a function of several resistor types, including wire meshes and punching metals, which are usually used for cementitious finishing. The disassembly properties were evaluated through various tests using conductive resistors in cementitious joints such as mortar. When steel fiber, punching metal, and wire mesh were used as conductive resistors, the cementitious modifiers could be weakened within 30 s. Cementitious joints with conductive resistors also showed complete disassembly with little residual bond strength.

Assembly and disassembly of the nucleolus during the cell cycle.

Science.gov (United States)

Hernandez-Verdun, Danièle

2011-01-01

The nucleolus is a large nuclear domain in which transcription, maturation and assembly of ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains reflects the compartmentation of the machineries related to active or inactive transcription of the ribosomal DNA, ribosomal RNA processing and assembly with ribosomal proteins of the two (40S and 60S) ribosomal subunits. The assembly of the nucleoli during telophase/early G(1) depends on pre-existing machineries inactivated during prophase (the transcription machinery and RNP processing complexes) and on partially processed 45S rRNAs inherited throughout mitosis. In telophase, the 45S rRNAs nucleate the prenucleolar bodies and order the dynamics of nucleolar assembly. The assembly/disassembly processes of the nucleolus depend on the equilibrium between phosphorylation/dephosphorylation of the transcription machinery and on the RNP processing complexes under the control of the CDK1-cyclin B kinase and PP1 phosphatases. The dynamics of assembly/disassembly of the nucleolus is time and space regulated.

Corrosion of aluminum alloys in a reactor disassembly basin

International Nuclear Information System (INIS)

Howell, J.P.; Zapp, P.E.; Nelson, D.Z.

1992-01-01

This document discusses storage of aluminum clad fuel and target tubes of the Mark 22 assembly takes place in the concrete-lined, light-water-filled, disassembly basins located within each reactor area at the Savannah River Site (SRS). A corrosion test program has been conducted in the K-Reactor disassembly basin to assess the storage performance of the assemblies and other aluminum clad components in the current basin environment. Aluminum clad alloys cut from the ends of actual fuel and target tubes were originally placed in the disassembly water basin in December 1991. After time intervals varying from 45--182 days, the components were removed from the basin, photographed, and evaluated metallographically for corrosion performance. Results indicated that pitting of the 8001 aluminum fuel clad alloy exceeded the 30-mil (0.076 cm) cladding thickness within the 45-day exposure period. Pitting of the 1100 aluminum target clad alloy exceeded the 30-mil (0.076 cm) clad thickness in 107--182 days exposure. The existing basin water chemistry is within limits established during early site operations. Impurities such as Cl - , NO 3 - and SO 4 - are controlled to the parts per million level and basin water conductivity is currently 170--190 μmho/cm. The test program has demonstrated that the basin water is aggressive to the aluminum components at these levels. Other storage basins at SRS and around the US have successfully stored aluminum components for greater than ten years without pitting corrosion. These basins have impurity levels controlled to the parts per billion level (1000X lower) and conductivity less than 1.0 μmho/cm

Spent fuel disassembly and canning programs at the Barnwell Nuclear Fuel Plant (BNFP)

International Nuclear Information System (INIS)

Townes, G.A.

1979-10-01

Methods of disassembling and canning spent fuel to allow more efficient storage are being investigated at the BNFP. Studies and development programs are aimed at dry disassembly of fuel to allow storage and shipment of fuel pins rather than full fuel assemblies. Results indicate that doubling existing storage capacity or tripling the carrying capacity of existing transportation equipment is achievable. Disassembly could be performed in the BNFP hot cells at rates of about 12 to 15 assemblies per day

Low cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus.

Science.gov (United States)

Soonthornsit, Jeerawat; Yamaguchi, Yoko; Tamura, Daisuke; Ishida, Ryuichi; Nakakoji, Yoko; Osako, Shiho; Yamamoto, Akitsugu; Nakamura, Nobuhiro

2014-11-01

The Golgi apparatus was dramatically disassembled when cells were incubated in a low pH medium. The cis-Golgi disassembled quickly, extended tubules and spread to the periphery of cells within 30 min. In contrast, medial- and trans-Golgi were fragmented in significantly larger structures of smaller numbers at a slower rate and remained largely in structures distinct from the cis-Golgi. Electron microscopy revealed the complete disassembly of the Golgi stack in low pH treated cells. The effect of low pH was reversible; the Golgi apparatus reassembled to form a normal ribbon-like structure within 1-2h after the addition of a control medium. The anterograde ER to Golgi transport and retrograde Golgi to ER transport were both reduced under low pH. Phospholipase A2 inhibitors (ONO, BEL) effectively suppressed the Golgi disassembly, suggesting that the phospholipase A2 was involved in the Golgi disassembly. Over-expression of Rab1, 2, 30, 33 and 41 also suppressed the Golgi disassembly under low pH, suggesting that they have protective role against Golgi disassembly. Low pH treatment reduced cytoplasmic pH, but not the luminal pH of the Golgi apparatus, strongly suggesting that reduction of the cytoplasmic pH triggered the Golgi disassembly. Because a lower cytoplasmic pH is induced in physiological or pathological conditions, disassembly of the Golgi apparatus and reduction of vesicular transport through the Golgi apparatus may play important roles in cell physiology and pathology. Furthermore, our findings indicated that low pH treatment can serve as an important tool to analyze the molecular mechanisms that support the structure and function of the Golgi apparatus. Copyright © 2014 Elsevier Inc. All rights reserved.

pH-Sensitive Reversible Programmed Targeting Strategy by the Self-Assembly/Disassembly of Gold Nanoparticles.

Science.gov (United States)

Ma, Jinlong; Hu, Zhenpeng; Wang, Wei; Wang, Xinyu; Wu, Qiang; Yuan, Zhi

2017-05-24

A reversible programmed targeting strategy could achieve high tumor accumulation due to its long blood circulation time and high cellular internalization. Here, targeting ligand-modified poly(ethylene glycol) (PEG-ligand), dibutylamines (Bu), and pyrrolidinamines (Py) were introduced on the surface of gold nanoparticles (Au NPs) for reversible shielding/deshielding of the targeting ligands by pH-responsive self-assembly. Hydrophobic interaction and steric repulsion are the main driving forces for the self-assembly/disassembly of Au NPs. The precise self-assembly (pH ≥ 7.2) and disassembly (pH ≤ 6.8) of Au NPs with different ligands could be achieved by fine-tuning the modifying molar ratio of Bu and Py (R m ), which followed the formula R m = 1/(-0.0013X 2 + 0.0323X + 1), in which X is the logarithm of the partition coefficient of the targeting ligand. The assembled/disassembled behavior of Au NPs at pH 7.2 and 6.8 was confirmed by transmission electron microscopy and dynamic light scattering. Enzyme-linked immunosorbent assays and cellular uptake studies showed that the ligands could be buried inside the assembly and exposed when disassembled. More importantly, this process was reversible, which provides the possibility of prolonging blood circulation by shielding ligands associated with the NPs that were effused from tumor tissue.

Microcanonical simulation of nuclear disassembly

International Nuclear Information System (INIS)

Koonin, S.E.; Randrup, J.

1986-01-01

There is considerable interest in the disassembly of the hot nuclear matter produced in high-energy nuclear collisions. A particular stimulus has been the prospect of observing a nuclear liquid-gas phase transition. On rather general grounds, such a transition is expected to occur in nuclear matter at subsaturation densities with temperatures of 10-20 MeV. However, virtually all previous discussions of this phenomenon have been based on thermodynamical considerations valid for infinite, non-interacting systems and the qualitative validity of the results has not been ascertained for the relatively small, finite, interacting systems of practical relevance. Nor is it clear how the occurrence of the phase transition will manifest itself in the asymptotically observed fragment distribution. To progress in these matters, the authors have formulated a microcanonical simulation of the disassembly process, including interfragment interactions. It is a natural refinement of the grand canonical model first presented in [1] and further developed in [2] and is also a exact version of the model developed in [3] for the generation of complete multifragment events in medium-energy collisions. In this contribution, the authors give a brief description of the key ingredients in the model and its numerical implementation

Effects of reactive oxygen species on cellular wall disassembly of banana fruit during ripening.

Science.gov (United States)

Cheng, Guiping; Duan, Xuewu; Shi, John; Lu, Wangjin; Luo, Yunbo; Jiang, Weibo; Jiang, Yueming

2008-07-15

Fruit softening is generally attributed to cell wall disassembly. Experiments were conducted to investigate effects of various reactive oxygen species (ROS) on in vitro cellular wall disassembly of harvested banana fruit. The alcohol-extracted insoluble residue (AEIR) was obtained from the pulp tissues of banana fruit at various ripening stages and then used to examine the disassembly of cellular wall polysaccharides in the presence of superoxide anion (O2(-)), hydrogen peroxide (H2O2) or hydroxyl radical (OH) and their scavengers. The presence of OH accelerated significantly disassembly of cellular wall polysaccharides in terms of the increase in contents of total sugars released and uronic acid, and the decrease in molecular mass of soluble polysaccharides, using gel permeation chromatography. However, the treatment with H2O2 or O2(-) showed no significant effect on the disassembly of cellular wall polysaccharides. Furthermore, the degradation of the de-esterified AEIR was more susceptible to OH attack than the esterified AEIR. In addition, the effect of OH could be inhibited in the presence of OH scavenger. This study suggests that disassembly of cellular wall polysaccharides could be initiated by OH as the solublisation of the polysaccharides increased, which, in turn, accelerated fruit softening. Copyright © 2008 Elsevier Ltd. All rights reserved.

Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.

Science.gov (United States)

Monroe, Nicole; Hill, Christopher P

2016-05-08

Meiotic clade AAA ATPases (ATPases associated with diverse cellular activities), which were initially grouped on the basis of phylogenetic classification of their AAA ATPase cassette, include four relatively well characterized family members, Vps4, spastin, katanin and fidgetin. These enzymes all function to disassemble specific polymeric protein structures, with Vps4 disassembling the ESCRT-III polymers that are central to the many membrane-remodeling activities of the ESCRT (endosomal sorting complexes required for transport) pathway and spastin, katanin p60 and fidgetin affecting multiple aspects of cellular dynamics by severing microtubules. They share a common domain architecture that features an N-terminal MIT (microtubule interacting and trafficking) domain followed by a single AAA ATPase cassette. Meiotic clade AAA ATPases function as hexamers that can cycle between the active assembly and inactive monomers/dimers in a regulated process, and they appear to disassemble their polymeric substrates by translocating subunits through the central pore of their hexameric ring. Recent studies with Vps4 have shown that nucleotide-induced asymmetry is a requirement for substrate binding to the pore loops and that recruitment to the protein lattice via MIT domains also relieves autoinhibition and primes the AAA ATPase cassettes for substrate binding. The most striking, unifying feature of meiotic clade AAA ATPases may be their MIT domain, which is a module that is found in a wide variety of proteins that localize to ESCRT-III polymers. Spastin also displays an adjacent microtubule binding sequence, and the presence of both ESCRT-III and microtubule binding elements may underlie the recent findings that the ESCRT-III disassembly function of Vps4 and the microtubule-severing function of spastin, as well as potentially katanin and fidgetin, are highly coordinated. Copyright © 2015 Elsevier Ltd. All rights reserved.

Capillarity-induced disassembly of virions in carbon nanotubes

Energy Technology Data Exchange (ETDEWEB)

Fan Xiaobin; Peng Wenchao; Li Yang; Li Xianyu; Zhang Guoliang; Zhang Fengbao [School of Chemical Engineering and Technology, Tianjin University, Tianjin (China); Barclay, J Elaine; Evans, David J [Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH (United Kingdom)], E-mail: fbzhang@tju.edu.cn

2008-04-23

Studying the transport and fate of viruses through nanochannels is of great importance. By using the nanochannel of a carbon nanotube (CNT) as an ideal model, we evaluated the possibility of capillarity-induced viral transport through a closely fitting nanochannel and explored the mechanisms involved. It is shown both experimentally and theoretically that Cowpea mosaic virus can enter CNTs by capillarity. However, when introduced into a nanotube the protein capsid may disassemble. During the initial capillary filling stage, anomalous needle-shaped high pressure exists in the centre of the nanotube's entrance. This high pressure, combining with the significant negative pressure within the nanotube, may account for the disassembly of the virions.

The Effect of Uncertain End-of-Life Product Quality and Consumer Incentives on Partial Disassembly Sequencing in Value Recovery Operations

OpenAIRE

Rickli, Jeremy Lewis

2013-01-01

This dissertation addresses gaps in the interaction between End-of-Life (EoL) product acquisition systems and disassembly sequencing. The research focuses on two remanufacturing research problems; 1) modeling uncertain EoL product quality, quantity, and timing in regards to EoL product acquisition and disassembly sequencing and 2) designing EoL product acquisition schemes considering EoL product uncertainty. The main research objectives within these areas are; analyzing, predicting, and contr...

Out pile test of a disassembly tool for the intermediate examination of nuclear fuel rods

International Nuclear Information System (INIS)

Hong, Jintae; Joung, Chang-Young; Ahn, Sung-Ho; Yang, Tae-Ho; Jang, Seo-Yoon; Park, Seung-Jae

2016-01-01

The two fuel rod assemblies are assembled with a bayonet coupler, and the non-instrumented fuel rod assembly can be disassembled for intermediate examination. A tool to disassemble the non-instrumented fuel rod assembly from the test rig was developed, and steel wires are connected to the tool to operate release function. In this study, an assembly plug with a quick plug typed bayonet coupler and the accompanying disassembly tool was designed to prevent the interference problem. A test rig mockup was fabricated, and performance test was carried out in the laboratory. And, the out pile test was also carried out in the single channel test loop established in the KAERI. In this study, a modified coupler design to disassemble the non-instrumented fuel rod assembly from the test rig for the intermediate examination was suggested to solve interference problem of previous design. The performance of the modified design was verified by test mockup fabricated with the modified coupler design and accompanied disassembly tool design. Finally, out pile test was carried out in the single channel test loop in the KAERI, and the test rig and the disassembly tool showed good performance and reliability. The developed technique will be useful to the periodic intermediate examination of nuclear fuel rods

Out pile test of a disassembly tool for the intermediate examination of nuclear fuel rods

Energy Technology Data Exchange (ETDEWEB)

Hong, Jintae; Joung, Chang-Young; Ahn, Sung-Ho; Yang, Tae-Ho; Jang, Seo-Yoon; Park, Seung-Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

The two fuel rod assemblies are assembled with a bayonet coupler, and the non-instrumented fuel rod assembly can be disassembled for intermediate examination. A tool to disassemble the non-instrumented fuel rod assembly from the test rig was developed, and steel wires are connected to the tool to operate release function. In this study, an assembly plug with a quick plug typed bayonet coupler and the accompanying disassembly tool was designed to prevent the interference problem. A test rig mockup was fabricated, and performance test was carried out in the laboratory. And, the out pile test was also carried out in the single channel test loop established in the KAERI. In this study, a modified coupler design to disassemble the non-instrumented fuel rod assembly from the test rig for the intermediate examination was suggested to solve interference problem of previous design. The performance of the modified design was verified by test mockup fabricated with the modified coupler design and accompanied disassembly tool design. Finally, out pile test was carried out in the single channel test loop in the KAERI, and the test rig and the disassembly tool showed good performance and reliability. The developed technique will be useful to the periodic intermediate examination of nuclear fuel rods.

Digital mock-up for the spent fuel disassembly processes

International Nuclear Information System (INIS)

Lee, J. Y.; Kim, S. H.; Song, T. G.; Kim, Y. H.; Hong, D. H.; Yoon, J. S.

2000-12-01

In this study, the graphical design system is developed and the digital mock-up is implemented for designing the spent fuel handling and disassembly processes. The system consists of a 3D graphical modeling system, a devices assembling system, and a motion simulation system. This system is used throughout the design stages from the conceptual design to the motion analysis. By using this system, all the process involved in the spent fuel handling and disassembly processes are analyzed and optimized. Also, this system is used in developing the on-line graphic simulator which synchronously simulates the motion of the equipment in a real time basis by connecting the device controllers with the graphic server through the TCP/IP network. This simulator can be effectively used for detecting the malfunctions of the process equipment which is remotely operated. Thus, the simulator enhances the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process. The graphical design system and the digital mock-up system can be effectively used for designing the process equipment, as well as the optimized process and maintenance process. And the on-line graphic simulator can be an alternative of the conventional process monitoring system which is a hardware based system

Preliminary topical report on comparison reactor disassembly calculations

International Nuclear Information System (INIS)

McLaughlin, T.P.

1975-11-01

Preliminary results of comparison disassembly calculations for a representative LMFBR model (2100-l voided core) and arbitrary accident conditions are described. The analytical methods employed were the computer programs: FX2-POOL, PAD, and VENUS-II. The calculated fission energy depositions are in good agreement, as are measures of the destructive potential of the excursions, kinetic energy, and work. However, in some cases the resulting fuel temperatures are substantially divergent. Differences in the fission energy deposition appear to be attributable to residual inconsistencies in specifying the comparison cases. In contrast, temperature discrepancies probably stem from basic differences in the energy partition models inherent in the codes. Although explanations of the discrepancies are being pursued, the preliminary results indicate that all three computational methods provide a consistent, global characterization of the contrived disassembly accident

Status of the pit disassembly and conversion facility

International Nuclear Information System (INIS)

Wood, Warren T.; Christensen, Lowell T.

2000-01-01

A planned new facility, the Pit Disassembly and Conversion Facility (PDCF), will be used to disassemble the nation's inventory of surplus nuclear weapons pits and convert the plutonium from those pits into a form suitable for storage, international inspection, and final disposition. Sized to handle 35 metric tons of plutonium from pits and other sources over its 10-year operating life, the PDCF will apply the Advanced Recovery and Integrated Extraction System (ARIES) technology. ARIES process technology has been developed at Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL), and an integrated system is being demonstrated at LANL. The Los Alamos National Laboratory is the lead for technical design oversight of the PDCF. Technical data gained from the ARIES demonstrations is integral for the proper design of the PDCF

Centralized disassembly and packaging of spent fuel in the DOE spent fuel management system

International Nuclear Information System (INIS)

Johnson, E.R.

1986-01-01

In October 1984, E.R. Johnson Associates, Inc. (JAI) initiated a study of the prospective use of a centralized facility for the disassembly and packaging of spent fuel to support the various elements of the US Dept. of Energy (DOE) spent fuel management system, including facilities for monitored retrievable storage (MRS) and repositories. It was DOE's original plan to receive spent fuel at each repository where it would be disassembled and packaged (overpacked) for disposal purposes. Subsequently, DOE considered the prospective use of MRS of spent fuel as an option for providing safe and reliable management of spent fuel. This study was designed to consider possible advantages of the use of centralized facilities for disassembly and packaging of spent fuel at whose location storage facilities could be added as required. The study was divided into three principal technical tasks that covered: (a) development of requirements and criteria for the central disassembly and packaging facility and associated systems. (2) Development of conceptual designs for the central disassembly and packaging facility and associated systems. (3) Estimation of capital and operating costs involved for all system facilities and determination of life cycle costs for various scenarios of operation - for comparison with the reference system

Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips.

Science.gov (United States)

Driver, Jonathan W; Geyer, Elisabeth A; Bailey, Megan E; Rice, Luke M; Asbury, Charles L

2017-06-19

Disassembling microtubules can generate movement independently of motor enzymes, especially at kinetochores where they drive chromosome motility. A popular explanation is the 'conformational wave' model, in which protofilaments pull on the kinetochore as they curl outward from a disassembling tip. But whether protofilaments can work efficiently via this spring-like mechanism has been unclear. By modifying a previous assay to use recombinant tubulin and feedback-controlled laser trapping, we directly demonstrate the spring-like elasticity of curling protofilaments. Measuring their mechanical work output suggests they carry ~25% of the energy of GTP hydrolysis as bending strain, enabling them to drive movement with efficiency similar to conventional motors. Surprisingly, a β-tubulin mutant that dramatically slows disassembly has no effect on work output, indicating an uncoupling of disassembly speed from protofilament strain. These results show the wave mechanism can make a major contribution to kinetochore motility and establish a direct approach for measuring tubulin mechano-chemistry.

Improved Nondestructive Disassembly Process using Augmented Reality and RFID Product/Part Tracking

Directory of Open Access Journals (Sweden)

Ile Mircheski

2017-11-01

Full Text Available The waste from electric and electronic equipment and discarded automobiles in the past grew rapidly and resulted with waste in billions of tones. The aim of this paper is to present an improved non-destructive disassembly process of electromechanical products using augmented reality based devices, such as glasses, tablets or mobile phones, and RFID technology for valuable product/part tracking. The proposed method includes tagging of components of interest in the product assembly by using a RFID tag. The valuable product is marked with specific ID number written in the RFID tag, in order to declare the product. The relevant data such as material and weight of components, guidelines for non-destructive disassembly for the valuable product and removing of component of interest will be obtained with the assistance of RFID tag and a centralized database. This modular system offers guidelines for the non-destructive disassembly process for obtaining valuable component of interest intended for easy repairs, remanufacture, reuse or recycling. The guidelines are in video presentation format using augmented reality for easy visualization of non-destructive disassembly process. The benefits of proposed modular system includes biggest percentage of reuse of the valuable components, easy maintaining, improved material recycling, environmental protection and greater total return form end of life products.

Disassembling and rebuilding 900 MW unit fuel assemblies in Celimene

International Nuclear Information System (INIS)

Giquel, G.; Leseur, A.; Pillet, C.; Van Craeynest, J.C.

1987-01-01

The Celimene high activity laboratory, in the Nuclear Research Centre of Saclay, has equipment for and experience of disassembling and rebuilding fuel assemblies from 900 MW light water reactors. These operations have been performed for R and D purposes; they allow removal for investigation of some of the fuel rods and examination of the skeleton. The rebuilt assemblies are sent to the fuel reprocessing plant. Reirradiation of these assemblies has not been considered so far and would require modifications of the procedure and of parts of the new skeleton. Disassembling and rebuilding have already been performed on three assemblies and a fourth one will be rebuilt in the coming months [fr

The assembly and disassembly of ecological networks.

Science.gov (United States)

Bascompte, Jordi; Stouffer, Daniel B

2009-06-27

Global change has created a severe biodiversity crisis. Species are driven extinct at an increasing rate, and this has the potential to cause further coextinction cascades. The rate and shape of these coextinction cascades depend very much on the structure of the networks of interactions across species. Understanding network structure and how it relates to network disassembly, therefore, is a priority for system-level conservation biology. This process of network collapse may indeed be related to the process of network build-up, although very little is known about both processes and even less about their relationship. Here we review recent work that provides some preliminary answers to these questions. First, we focus on network assembly by emphasizing temporal processes at the species level, as well as the structural building blocks of complex ecological networks. Second, we focus on network disassembly as a consequence of species extinctions or habitat loss. We conclude by emphasizing some general rules of thumb that can help in building a comprehensive framework to understand the responses of ecological networks to global change.

ARIES pit disassembly-safeguards issues for transparency

International Nuclear Information System (INIS)

Fearey, B.L.; Cremers, T.L.

1995-01-01

Historic changes are now occurring in U.S. nonproliferation and arms control policy. The quantity of nuclear weapons required to provide a deterrence has decreased (especially with the end of the Cold War). Further, various bilateral and multilateral treaties now require the removal of numerous nuclear weapons from the U.S. stockpile. Although the removal of such weapons appears straightforward, the final disposition of the surplus weapons-grade nuclear material must be carefully considered. Domestically, several plutonium disposition plans are now under consideration concerning long-term safety, materials accounting, environmental impact, accessibility, and long-term containment. The Automated Retirement and Integrated Extraction System (ARIES) currently under development at Los Alamos National Laboratory is one such disposition method for the disassembly of plutonium weapons components (pits). The ARIES system integrates and automates several features: disassembly of pits, consolidation of the plutonium material, on-line measurement of final products, waste streams, and long-term packaging. Clearly, in any plutonium disposition plan, the safeguards aspects of materials control and accounting and the security aspects must be carefully considered and evaluated

Spent-fuel disassembly and canning programs at the Barnwell Nuclear Fuel Plant (BNFP)

International Nuclear Information System (INIS)

Townes, G.A.

1980-02-01

Doubling pool storage and tripling truck cask shipping capability appear feasible based on preliminary development work performed at the BNFP. This would be accomplished by disassembly of the fuel assembly and canning of the fuel pins. The dry, remote disassembly and canning in the headend cells offer adequate rates, easily controlled operator exposure, and visual inspection of the fuel pins and operations through shielded windows

Advanced disassembling technique of irradiated driver fuel assembly for continuous irradiation of fuel pins

International Nuclear Information System (INIS)

Ichikawa, Shoichi; Haga, Hiroyuki; Katsuyama, Kozo; Maeda, Koji; Nishinoiri, Kenji

2012-01-01

It was necessary to carry out continuous irradiation tests in order to obtain the irradiation data of high burn-up fuel and high neutron dose material for FaCT (Fast Reactor Cycle Technology Development) project. There, the disassembling technique of an irradiated fuel assembly was advanced in order to realize further continuous irradiation tests. Although the conventional disassembling technique had been cutting a lower end-plug of a fuel pin needed to fix fuel pins to an irradiation vehicle, the advanced disassembling technique did not need cutting a lower end-plug. As a result, it was possible to supply many irradiated fuel pins to various continuous irradiation tests for FaCT project. (author)

SAVANNAH RIVER SITE R REACTOR DISASSEMBLY BASIN IN SITU DECOMMISSIONING

Energy Technology Data Exchange (ETDEWEB)

Langton, C.; Blankenship, J.; Griffin, W.; Serrato, M.

2009-12-03

The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate in tact, structurally sound facilities that are no longer needed for their original purpose of, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate if from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,424 cubic meters or 31,945 cubic yards. Portland cement-based structural fill materials were design and tested for the reactor ISD project and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and work flow considerations, the recommended maximum lift height is 5 feet with 24 hours between lifts. Pertinent data and information related to the SRS 105-R-Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material designs

Integrating Safeguards into the Pit Disassembly and Conversion Facility

International Nuclear Information System (INIS)

Clark, T.G.

2002-01-01

In September 2000, the United States and the Russian Federation entered into an agreement which stipulates each country will irreversibly transform 34 metric tons of weapons-grade plutonium into material which could not be used for weapon purposes. Supporting the Department of Energy's (DOE) program to dispose of excess nuclear materials, the Pit Disassembly and Conversion Facility (PDCF) is being designed and constructed to disassemble the weapon ''pits'' and convert the nuclear material to an oxide form for fabrication into reactor fuel at the separate Mixed Oxide Fuel Fabrication Facility. The PDCF design incorporates automation to the maximum extent possible to facilitate material safeguards, reduce worker dose, and improve processing efficiency. This includes provisions for automated guided vehicle movements for shipping containers, material transport via automated conveyor between processes, remote process control monitoring, and automated Nondestructive Assay product systems

A Taxonomy and Comparison of Haptic Actions for Disassembly Tasks

National Research Council Canada - National Science Library

Bloomfield, Aaron; Deng, Yu; Wampler, Jeff; Rondot, Pascale; Harth, Dina; McManus, Mary; Badler, Norman

2003-01-01

.... We conducted a series of human subject experiments to compare user performance and preference on a disassembly task with and without haptic feedback using CyberGlove, Phantom, and SpaceMouse interfaces...

Optimization of Two-Level Disassembly/Remanufacturing/Assembly System with an Integrated Maintenance Strategy

Directory of Open Access Journals (Sweden)

Zouhour Guiras

2018-04-01

Full Text Available With an increase of environmental pressure on economic activities, reverse flow is increasingly important. It seeks to save resources, eliminate waste, and improve productivity. This paper investigates the optimization of the disassembly, remanufacturing and assembly system, taking into account assembly-disassembly system degradation. An analytical model is developed to consider disassembly, remanufacturing of used/end-of-life product and assembly of the finished product. The finished product is composed of remanufactured and new components. A maintenance policy is sequentially integrated to reduce the system unavailability. The aim of this study is to help decision-makers, under certain conditions, choose the most cost-effective process for them to satisfy the customer as well as to adapt to the potential risk that can perturb the disassembly-assembly system. A heuristic is developed to determine the optimal ordered date of the used end-of-life product as well as the optimum release dates of new external components. The results reveal that considering some remanufacturing and purchase components costs, the proposed model is more economical in comparison with a model without remanufactured parts. Numerical results are provided to illustrate the impact of the variation of the ordering cost and quality of the used end-of-life product on the system profitability. Finally, the risk due to system repair periods is discussed, which has an impact on managerial decision-making.

DISA- a computer code for accident analysis of fast reactor during disassembly phase

International Nuclear Information System (INIS)

Yadav, R.D.S.; Gupta, H.P.

2005-01-01

Analysis of the hypothetical transients in fast rectors that result in the disassembly of the reactor generally consists of three phases. In the phase-l, some initiating event like control rod ejection, coolant pump failure etc. is assumed to have taken place which leads the reactor to prompt critical state where fuel melting, sodium voiding etc. take place. In fast reactor normally the fuel is not in the optimum shape and further positive reactivity may be introduced into the system due to fuel melting. Fuel slumping is assumed to take place in this phase. If prompt criticality is reached as a result of the first phase, then disassembly phase is assumed to start. In this phase the neutron transient is followed till it is terminated by the disassembly of the core which takes place due to generation of high pressure gradients and which lead the core material to move from more worth region to less worth region. Doppler feed back is taken into account and reactivity feedback due to material movement is calculated by solving the hydrodynamics equations. The third phase will calculate the effect of this transient on the reactor vessel and containment. A computer code DISA for fast reactor DISAssembly phase, which is similar to the well known code VENUS has been developed. (author)

Alpha Decontamination and Disassembly Pilot Facility. Final report

International Nuclear Information System (INIS)

Daugherty, B.A.; Clark, H.E.

1985-04-01

The Alpha Decontamination and Disassembly (AD and D) Pilot Facility was built to develop and demonstrate a reference process for the decontamination and size reduction of noncombustible transuranic (TRU) waste. The goals of the reference process were to remove >99% of the surface contamination to the high-level waste tanks, and to achieve volume reduction factors greater than 15:1. Preliminary bench-scale decontamination work was accomplished at Savannah River Laboratory (SRL), establishing a reference decontamination process. Initially, the pilot facility did not achieve the decontamination goals. As the program continued, and modifications to the process were made, coupon analysis idicated that 99% of the surface contamination was removed to the high-level drain system. Prior to the AD and D Pilot Facility, no size reduction work had been done at SRL. Several other Department of Energy (DOE) facilities were experimenting with plasma arc torches for size reduction work. Their methods were employed in the AD and D hot cell with moderate success. The experimental work concluded with recommendations for further testing of other size reduction techniques. 11 figs., 6 tabs

What if the hand piece spring disassembles during robotic radical prostatectomy?

Science.gov (United States)

Akbulut, Ziya; Canda, Abdullah Erdem; Atmaca, Ali Fuat; Asil, Erem; Isgoren, Egemen; Balbay, Mevlana Derya

2011-01-01

Robot-assisted laparoscopic radical prostatectomy (RALRP) is successfully being performed for treating prostate cancer (PCa). However, instrumentation failure associated with robotic procedures represents a unique new problem. We report the successful completion of RALRP in spite of a disassembled hand piece spring during the procedure. A PubMed/Medline search was made concerning robotic malfunction and robot-assisted laparoscopic radical prostatectomy to discuss our experience. We performed RALRP in a 60-year-old male patient with localized PCa. During the procedure, the spring of the hand piece disassembled, and we were not able to reassemble it. We completed the procedure successfully however without fixing the disassembled hand piece spring. We were able to grasp tissue and needles when we brought our fingers together. The only movement we needed to do was to move fingers apart to release tissue or needles caught by robotic instrument. Although malfunction risk related to the da Vinci Surgical System seems to be very low, it might still occur. Sometimes, simple maneuvers may compensate for the failed function as occurred in our case. However, patients should be informed before the operation about the possibility of converting their procedure to laparoscopic or open due to robotic malfunction.

Phosphorylation of p37 is important for Golgi disassembly at mitosis

International Nuclear Information System (INIS)

Kaneko, Yayoi; Tamura, Kaori; Totsukawa, Go; Kondo, Hisao

2010-01-01

Research highlights: → p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis. → Phosphorylated p37 does not bind to Golgi membranes. → p37 phosphorylation inhibits p97/p37-mediated Golgi membrane fusion. -- Abstract: In mammals, the Golgi apparatus is disassembled at early mitosis and reassembled at the end of mitosis. For Golgi disassembly, membrane fusion needs to be blocked. Golgi biogenesis requires two distinct p97ATPase-mediated membrane fusion, the p97/p47 and p97/p37 pathways. We previously reported that p47 phosphorylation on Serine-140 by Cdc2 results in mitotic inhibition of the p97/p47 pathway . In this study, we demonstrate that p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis, and this phosphorylated p37 does not bind to Golgi membranes. Using an in vitro Golgi reassembly assay, we show that mutated p37(S56D, T59D), which mimics mitotic phosphorylation, does not cause any cisternal regrowth, indicating that p37 phosphorylation inhibits the p97/p37 pathway. Our results demonstrate that p37 phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis.

AGR-2 Irradiated Test Train Preliminary Inspection and Disassembly First Look

Energy Technology Data Exchange (ETDEWEB)

Ploger, Scott [Idaho National Lab. (INL), Idaho Falls, ID (United States); Demkowciz, Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-05-01

The AGR 2 irradiation experiment began in June 2010 and was completed in October 2013. The test train was shipped to the Materials and Fuels Complex in July 2014 for post-irradiation examination (PIE). The first PIE activities included nondestructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and their graphite fuel holders. Dimensional metrology was then performed on the compacts, graphite holders, and steel capsule shells. AGR 2 disassembly and metrology were performed with the same equipment used successfully on AGR 1 test train components. Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Disassembly of the AGR 2 test train and its capsules was conducted rapidly and efficiently by employing techniques refined during the AGR 1 disassembly campaign. Only one major difficulty was encountered while separating the test train into capsules when thermocouples (of larger diameter than used in AGR 1) and gas lines jammed inside the through tubes of the upper capsules, which required new tooling for extraction. Disassembly of individual capsules was straightforward with only a few minor complications. On the whole, AGR 2 capsule structural components appeared less embrittled than their AGR 1 counterparts. Compacts from AGR 2 Capsules 2, 3, 5, and 6 were in very good condition upon removal. Only relatively minor damage or markings were visible using high resolution photographic inspection. Compact dimensional measurements indicated radial shrinkage between 0.8 to 1.7%, with the greatest shrinkage observed on Capsule 2 compacts that were irradiated at higher temperature. Length shrinkage ranged from 0.1 to 0.9%, with by far the lowest axial shrinkage on Capsule 3 compacts�

SAVANNAH RIVER SITE R-REACTOR DISASSEMBLY BASIN IN-SITU DECOMMISSIONING -10499

Energy Technology Data Exchange (ETDEWEB)

Langton, C.; Serrato, M.; Blankenship, J.; Griffin, W.

2010-01-04

The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate intact, structurally sound facilities that are no longer needed for their original purpose, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the 105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate it from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,384 cubic meters or 31,894 cubic yards. Portland cement-based structural fill materials were designed and tested for the reactor ISD project, and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and material flow considerations, maximum lift heights and differential height requirements were determined. Pertinent data and information related to the SRS 105-R Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material

Modelling disassembled fuel bundles using CATHENA MOD-3.5a under LOCA/LOECC conditions

Energy Technology Data Exchange (ETDEWEB)

Lei, Q M; Sanderson, D B; Dutton, R [Atomic Energy of Canada Ltd., Pinawa, MB (Canada). Whiteshell Labs.

1996-12-31

CATHENA MOD-3.5a is a multipurpose thermalhydraulic computer code developed primarily to analyse postulated loss-of-coolant scenarios for CANDU nuclear reactors. The code contains a generalized heat transfer package that enables it to model the behaviour of a fuel channel in great detail. Throughout the development of the CATHENA code, considerable effort has been devoted to evaluating, validating and documenting its overall capability as a design and safety assessment tool. Specific attention has focused on its ability to predict fuel channel behaviour under postulated accident conditions. This paper describes an investigation of CATHENA`s ability to predict the thermal-chemical responses of a fuel channel in which the 37-element bundles were assumed to disassemble and rearrange into a closed-packed stack of elements at the bottom of the pressure tube. A representative disassembled bundle geometry was modelled during a simulated loss-of-coolant accident scenario using CATHENA MOD-3.5a/Rev 0, with superheated steam being the only coolant available. Thermal conduction in the radial and circumferential directions was calculated for individual fuel elements, the pressure tube, and the calandria tube. Radiation view factors for the intact and disassembled bundle geometries were calculated using a CATHENA utility program. Inter-element metal-to-metal contact was accounted for using the CATHENA solid-solid contact model. An offset pressure-tube configuration, representing a partially sagged pressure tube, and the effect of steam starvation on the exothermic zirconium-steam reaction, were included in the CATHENA model. The CATHENA-predicted results show a dramatic suppression of heat generation from the zirconium-steam reaction when bundle disassembly is initiated. The predicted results show a smaller temperature increase in the fuel sheaths and the pressure tube for the disassembled bundle geometry, compared to the temperature excursion for the intact bundle. (author

Disassembly and physical separation of electric/electronic components layered in printed circuit boards (PCB).

Science.gov (United States)

Lee, Jaeryeong; Kim, Youngjin; Lee, Jae-chun

2012-11-30

Although printed circuit boards (PCBs) contain various elements, only the major elements (i.e., those with content levels in wt% or over grade) of and precious metals (e.g., Ag, Au, and platinum groups) contained within PCBs can be recycled. To recover other elements from PCBs, the PCBs should be properly disassembled as the first step of the recycling process. The recovery of these other elements would be beneficial for efforts to conserve scarce resources, reuse electric/electronic components (EECs), and eliminate environmental problems. This paper examines the disassembly of EECs from wasted PCBs (WPCBs) and the physical separation of these EECs using a self-designed disassembling apparatus and a 3-step separation process of sieving, magnetic separation, and dense medium separation. The disassembling efficiencies were evaluated by using the ratio of grinding area (E(area)) and the weight ratio of the detached EECs (E(weight)). In the disassembly treatment, these efficiencies were improved with an increase of grinder speed and grinder height. 97.7% (E(area)) and 98% (E(weight)) could be accomplished ultimately by 3 repetitive treatments at a grinder speed of 5500 rpm and a grinder height of 1.5mm. Through a series of physical separations, most groups of the EECs (except for the diode, transistor, and IC chip groups) could be sorted at a relatively high separation efficiency of about 75% or more. To evaluate the separation efficiency with regard to the elemental composition, the distribution ratio (R(dis)) and the concentration ratio (R(conc)) were used. 15 elements could be separated with the highest R(dis) and R(conc) in the same separated division. This result implies that the recyclability of the elements is highly feasible, even though the initial content in EECs is lower than several tens of mg/kg. Copyright © 2012 Elsevier B.V. All rights reserved.

Development of the spent fuel disassembling process by utilizing the 3D graphic design technology

International Nuclear Information System (INIS)

Song, T. K.; Lee, J. Y.; Kim, S. H.; Yun, J. S.

2001-01-01

For developing the spent fuel disassembling process, the 3D graphic simulation has been established by utilizing the 3D graphic design technology which is widely used in the industry. The spent fuel disassembling process consists of a downender, a rod extraction device, a rod cutting device, a pellet extracting device and a skeleton compaction device. In this study, the 3D graphical design model of these devices is implemented by conceptual design and established the virtual workcell within kinematics to motion of each device. By implementing this graphic simulation, all the unit process involved in the spent fuel disassembling processes are analyzed and optimized. The 3D graphical model and the 3D graphic simulation can be effectively used for designing the process equipment, as well as the optimized process and maintenance process

Disassembling and modification of RA-3

International Nuclear Information System (INIS)

Tarizzo, R.D.

1990-01-01

The objective of this paper is to describe the partial disassembling and modification of RA-3, called the Modernization Project. It comprises all the technical and administrative steps directly related with this task. The improvement of RA-3 is a result of the lack of 90% enriched uranium obliging a change over to 20% enriched uranium. This brought about design modifications both in fuel elements and the reactor. The presentation of documents for the licensing authority as well as are detailed separately. The modernization project was divided in 25 tasks: 1) changing fuel element support table, 2) changing heat exchanger, 3) repairing of cooling towers, 4) repairing of primary circuit valves, 5) repairing of irradiation channels, 6) construction of a new sampler, 7) changing tangential channel, 8) cleaning and disassembling of reactor (inside), 9) changing continuous demineralizer (ion exchange column), 10) detection of failure in fuel elements, 11) modification of nuclear instrumentation, 12) modification of conventional instrumentation, 13) modification of electrical system, 14) changing telemanipulators, 15) construction of mechanism bridge, 16) changing a primary circuit valve when the heat exchanger is changed too, 17) painting ground floor, hall floor, and pump room floor with epoxy resin levelling, 18) installation of fire alarm system, 19) radioactive liquid discharge, 20) modification of secondary circuit (This task involves: a) installation of a third secondary pump, b) extension of this piping, c) installation of two 12 inch valves to the present cooling towers pools independent, d) installation of filtering system), 21) optimization hot water bed, 22) changing detector support table, 23) removal, decontamination and reinstallation of shielding, 25) changing pneumatic system

Phosphorylation and disassembly of intermediate filaments in mitotic cells

International Nuclear Information System (INIS)

Chou, Yinghao; Rosevear, E.; Goldman, R.D.

1989-01-01

As baby hamster kidney (BHK-21) cells enter mitosis, networks of intermediate filaments (IFs) are transformed into cytoplasmic aggregates of protofilaments. Coincident with this morphological change, the phosphate content of vimentin increases from 0.3 mol of P i per mol of protein in interphase to 1.9 mol of P i per mol of protein in mitosis. A similar increase in phosphate content is observed with desmin, from 0.5 mol of P i per mol of protein to 1.5 mol of P i per mol of protein. Fractionation of mitotic cell lysates by hydroxylapatite column chromatography reveals the presence of two IF protein kinase activities, designated as IF protein kinase I and IF protein kinase II. Comparison of two-dimensional 32 P-labeled phosphopeptide maps of vimentin and desmin phosphorylated in vivo in mitosis, and in vitro using partially purified kinase fractions, reveals extensive similarity in the two sets of phosphorylation sites. Phosphorylation of in vitro polymerized IFs by IF protein kinase II induces complete disassembly as determined by negative-stain electron microscopy. The results support the idea that the disassembly of IFs in mitosis is regulated by the phosphorylation of its subunit proteins

JY1 time scale: a new Kalman-filter time scale designed at NIST

International Nuclear Information System (INIS)

Yao, Jian; Parker, Thomas E; Levine, Judah

2017-01-01

We report on a new Kalman-filter hydrogen-maser time scale (i.e. JY1 time scale) designed at the National Institute of Standards and Technology (NIST). The JY1 time scale is composed of a few hydrogen masers and a commercial Cs clock. The Cs clock is used as a reference clock to ease operations with existing data. Unlike other time scales, the JY1 time scale uses three basic time-scale equations, instead of only one equation. Also, this time scale can detect a clock error (i.e. time error, frequency error, or frequency drift error) automatically. These features make the JY1 time scale stiff and less likely to be affected by an abnormal clock. Tests show that the JY1 time scale deviates from the UTC by less than  ±5 ns for ∼100 d, when the time scale is initially aligned to the UTC and then is completely free running. Once the time scale is steered to a Cs fountain, it can maintain the time with little error even if the Cs fountain stops working for tens of days. This can be helpful when we do not have a continuously operated fountain or when the continuously operated fountain accidentally stops, or when optical clocks run occasionally. (paper)

FaCT phase-I evaluation on the advanced aqueous reprocessing process (2). Development of mechanical disassembly and short stroke shearing systems for FBR fuel reprocessing

International Nuclear Information System (INIS)

Takeuchi, Masayuki; Kitagaki, Toru; Higuchi, Hidetoshi; Fukushima, Mineo; Washiya, Tadahiro; Kobayashi, Tsuguyuki

2011-01-01

JAEA promotes a development of an advanced head-end process in FaCT project. We selected mechanical cutting method for disassembly process and short stroke method for shearing process. In the FaCT phase-I, the criteria was set for decision about the innovative technology and some fundamental performances of the innovative technology such as precision, speed, durability, operation performance and system concept were discussed by the engineering test and design work. We designed and fabricated an engineering-scale test device for mechanical disassembly and short stroke shearing and have carried out the engineering tests using simulated fuel assemblies. As a part of the engineering test results, the effects of cutting conditions on the durability of cutting tool and cutting stability were discussed. Also, the reduction of magazine width is effective to improve the precision of sheared pin length, and the bundle of simulated fuel pins were successfully sheared to 10 ± 5mm, which is a target for the sheared pin length. The criteria for the mechanical disassembly technology and the short stroke shearing technology were satisfied, so we judged that the development of innovative technologies has worth going on for the next phase in the FaCT project. (author)

Design-only conceptual design report for pit disassembly and conversion facility. Rev 0

International Nuclear Information System (INIS)

Zygmunt, S.; Christensen, L.; Richardson, C.

1997-01-01

This design-only conceptual design report (DOCDR) was prepared to support a funding request by the Department of Energy (DOE)-Office of Fissile Material Disposition (OFMD) for engineering design of the Pit Disassembly and Conversion Facility (PDCF) Project No. 99-D-141. The PDCF will be used to disassemble the nation's inventory of surplus nuclear weapons pits and convert the plutonium recovered from those pits into a form suitable for storage, international inspection, and final disposition. The PDCF is a complex consisting of a hardened building that will contain the plutonium processes in a safe and secure manner, and conventional buildings and structures that will house support personnel, systems, and equipment. The PDCF uses the Advanced Recovery and Integrated Extraction System (ARIES), a low waste, modular pyroprocessing system to convert pits to plutonium oxide. The PDCF project consists of engineering and design, and construction of the buildings and structures, and engineering and design, procurement, installation, testing and start-up of equipment to disassemble pits and convert plutonium in pits to oxide form. The facility is planned to operate for 10 years, averaging 3.5 metric tons (3.86 tons) of plutonium metal per year. On conclusion of operations, the PDCF will be decontaminated and decommissioned

Design-only conceptual design report for pit disassembly and conversion facility. Rev 0

Energy Technology Data Exchange (ETDEWEB)

Zygmunt, S.; Christensen, L.; Richardson, C.

1997-12-12

This design-only conceptual design report (DOCDR) was prepared to support a funding request by the Department of Energy (DOE)-Office of Fissile Material Disposition (OFMD) for engineering design of the Pit Disassembly and Conversion Facility (PDCF) Project No. 99-D-141. The PDCF will be used to disassemble the nation`s inventory of surplus nuclear weapons pits and convert the plutonium recovered from those pits into a form suitable for storage, international inspection, and final disposition. The PDCF is a complex consisting of a hardened building that will contain the plutonium processes in a safe and secure manner, and conventional buildings and structures that will house support personnel, systems, and equipment. The PDCF uses the Advanced Recovery and Integrated Extraction System (ARIES), a low waste, modular pyroprocessing system to convert pits to plutonium oxide. The PDCF project consists of engineering and design, and construction of the buildings and structures, and engineering and design, procurement, installation, testing and start-up of equipment to disassemble pits and convert plutonium in pits to oxide form. The facility is planned to operate for 10 years, averaging 3.5 metric tons (3.86 tons) of plutonium metal per year. On conclusion of operations, the PDCF will be decontaminated and decommissioned.

Montmorillonite-induced Bacteriophage φ6 Disassembly

Science.gov (United States)

Trusiak, A.; Gottlieb, P.; Katz, A.; Alimova, A.; Steiner, J. C.; Block, K. A.

2012-12-01

It is estimated that there are 1031 virus particles on Earth making viruses an order of magnitude more prevalent in number than prokaryotes with the vast majority of viruses being bacteriophages. Clays are a major component of soils and aquatic sediments and can react with RNA, proteins and bacterial biofilms. The clays in soils serve as an important moderator between phage and their host bacteria, helping to preserve the evolutionary balance. Studies on the effects of clays on viral infectivity have given somewhat contradictory results; possibly a consequence of clay-virus interactions being dependent on the unique structure of particular viruses. In this work, the interaction between montmorillonite and the bacteriophage φ6 is investigated. φ6 is a member of the cystovirus family that infects Pseudomonas syringe, a common plant pathogen. As a member of the cystovirus family with an enveloped structure, φ6 serves as a model for reoviruses, a human pathogen. Experiments were conducted with φ6 suspended in dilute, purified homoionic commercial-grade montmorillonite over a range of virus:clay ratios. At a 1:100000 virus:clay ratio, the clay reduced viral infectivity by 99%. The minimum clay to virus ratio which results in a measurable reduction of P. syringae infection is 1:1. Electron microscopy demonstrates that mixed suspensions of smectite and virus co-aggregate to form flocs encompassing virions within the smectite. Both free viral particles as well as those imbedded in the flocs are seen in the micrographs to be missing the envelope- leaving only the nucleocapsid (NC) intact; indicating that smectite inactivates the virus by envelope disassembly. These results have strong implications in the evolution of both the φ6 virus and its P. syringae host cells. TEM of aggregate showing several disassembled NCs.

AGC-2 Disassembly Report

Energy Technology Data Exchange (ETDEWEB)

William Windes

2014-05-01

The Next Generation Nuclear Plant (NGNP) Graphite Research and Development (R&D) Program is currently measuring irradiated material properties for predicting the behavior and operating performance of new nuclear graphite grades available for use within the cores of new very high temperature reactor designs. The Advanced Graphite Creep (AGC) experiment, consisting of six irradiation capsules, will generate irradiated graphite performance data for NGNP reactor operating conditions. The AGC experiment is designed to determine the changes to specific material properties such as thermal diffusivity, thermal expansion, elastic modulus, mechanical strength, irradiation induced dimensional change rate, and irradiation creep for a wide variety of nuclear grade graphite types over a range of high temperature, and moderate doses. A series of six capsules containing graphite test specimens will be used to expose graphite test samples to a dose range from 1 to 7 dpa at three different temperatures (600, 900, and 1200°C) as described in the Graphite Technology Development Plan. Since irradiation induced creep within graphite components is considered critical to determining the operational life of the graphite core, some of the samples will also be exposed to an applied load to determine the creep rate for each graphite type under both temperature and neutron flux. All six AGC capsules in the experiment will be irradiated in the Advanced Test Reactor (ATR). AGC-1 and AGC-2 will be irradiated in the south flux trap and AGC-3–AGC-6 will be irradiated in the east flux trap. The change in flux traps is due to NGNP irradiation priorities requiring the AGC experiment to be moved to accommodate Fuel irradiation experiments. After irradiation, all six AGC capsules will be cooled in the ATR Canal, sized for shipment, and shipped to the Materials and Fuels Complex (MFC) where the capsule will be disassembled in the Hot Fuel Examination Facility (HFEF). During disassembly, the metallic

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

Science.gov (United States)

Caillat, Christophe; Macheboeuf, Pauline; Wu, Yuanfei; McCarthy, Andrew A.; Boeri-Erba, Elisabetta; Effantin, Gregory; Göttlinger, Heinrich G.; Weissenhorn, Winfried; Renesto, Patricia

2015-12-01

The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved key interface residues are shown to be important for MsVps4 assembly, ATPase activity in vitro, ESCRT-III disassembly in vitro and HIV-1 budding. ADP binding leads to conformational changes within the protomer, which might propagate within the ring structure. All ATP-binding sites are accessible and the pseudohexamer binds six ATP with micromolar affinity in vitro. In contrast, ADP occupies one high-affinity and five low-affinity binding sites in vitro, consistent with conformational asymmetry induced on ATP hydrolysis. The structure represents a snapshot of an assembled Vps4 conformation and provides insight into the molecular motions the ring structure undergoes in a concerted action to couple ATP hydrolysis to ESCRT-III substrate disassembly.

A Trio-Rac1-PAK1 signaling axis drives invadopodia disassembly

Science.gov (United States)

Moshfegh, Yasmin; Bravo-Cordero, Jose Javier; Miskolci, Veronika; Condeelis, John; Hodgson, Louis

2014-01-01

Rho family GTPases control cell migration and participate in the regulation of cancer metastasis. Invadopodia, associated with invasive tumor cells, are crucial for cellular invasion and metastasis. To study Rac1 GTPase in invadopodia dynamics, we developed a genetically-encoded, single-chain Rac1 Fluorescence Resonance Energy Transfer (FRET) biosensor. The biosensor shows Rac1 activity exclusion from the core of invadopodia, and higher activity when invadopodia disappear, suggesting that reduced Rac1 activity is necessary for their stability, and Rac1 activation is involved in disassembly. Photoactivating Rac1 at invadopodia confirmed this previously-unknown Rac1 function. We built an invadopodia disassembly model, where a signaling axis involving TrioGEF, Rac1, PAK1, and phosphorylation of cortactin, causing invadopodia dissolution. This mechanism is critical for the proper turnover of invasive structures during tumor cell invasion, where a balance of proteolytic activity and locomotory protrusions must be carefully coordinated to achieve a maximally invasive phenotype. PMID:24859002

Assembly, operation and disassembly manual for the Battelle Large Volume Water Sampler (BLVWS)

International Nuclear Information System (INIS)

Thomas, V.W.; Campbell, R.M.

1984-12-01

Assembly, operation and disassembly of the Battelle Large Volume Water Sampler (BLVWS) are described in detail. Step by step instructions of assembly, general operation and disassembly are provided to allow an operator completely unfamiliar with the sampler to successfully apply the BLVWS to his research sampling needs. The sampler permits concentration of both particulate and dissolved radionuclides from large volumes of ocean and fresh water. The water sample passes through a filtration section for particle removal then through sorption or ion exchange beds where species of interest are removed. The sampler components which contact the water being sampled are constructed of polyvinylchloride (PVC). The sampler has been successfully applied to many sampling needs over the past fifteen years. 9 references, 8 figures

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

Directory of Open Access Journals (Sweden)

Marija Maric

2017-03-01

Full Text Available Disassembly of the Cdc45-MCM-GINS (CMG DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 “segregase”. Here, we employ a screen to identify partners of budding yeast Cdc48 that are important for disassembly of ubiquitylated CMG helicase at the end of chromosome replication. We demonstrate that the ubiquitin-binding Ufd1-Npl4 complex recruits Cdc48 to ubiquitylated CMG. Ubiquitylation of CMG in yeast cell extracts is dependent upon lysine 29 of Mcm7, which is the only detectable site of ubiquitylation both in vitro and in vivo (though in vivo other sites can be modified when K29 is mutated. Mutation of K29 abrogates in vitro recruitment of Ufd1-Npl4-Cdc48 to the CMG helicase, supporting a model whereby Ufd1-Npl4 recruits Cdc48 to ubiquitylated CMG at the end of chromosome replication, thereby driving the disassembly reaction.

Artificial biofilms establish the role of matrix interactions in staphylococcal biofilm assembly and disassembly

Science.gov (United States)

Stewart, Elizabeth J.; Ganesan, Mahesh; Younger, John G.; Solomon, Michael J.

2015-01-01

We demonstrate that the microstructural and mechanical properties of bacterial biofilms can be created through colloidal self-assembly of cells and polymers, and thereby link the complex material properties of biofilms to well understood colloidal and polymeric behaviors. This finding is applied to soften and disassemble staphylococcal biofilms through pH changes. Bacterial biofilms are viscoelastic, structured communities of cells encapsulated in an extracellular polymeric substance (EPS) comprised of polysaccharides, proteins, and DNA. Although the identity and abundance of EPS macromolecules are known, how these matrix materials interact with themselves and bacterial cells to generate biofilm morphology and mechanics is not understood. Here, we find that the colloidal self-assembly of Staphylococcus epidermidis RP62A cells and polysaccharides into viscoelastic biofilms is driven by thermodynamic phase instability of EPS. pH conditions that induce phase instability of chitosan produce artificial S. epidermidis biofilms whose mechanics match natural S. epidermidis biofilms. Furthermore, pH-induced solubilization of the matrix triggers disassembly in both artificial and natural S. epidermidis biofilms. This pH-induced disassembly occurs in biofilms formed by five additional staphylococcal strains, including three clinical isolates. Our findings suggest that colloidal self-assembly of cells and matrix polymers produces biofilm viscoelasticity and that biofilm control strategies can exploit this mechanism. PMID:26272750

Spiropyran-Decorated SiO₂-Pt Janus Micromotor: Preparation and Light-Induced Dynamic Self-Assembly and Disassembly.

Science.gov (United States)

Zhang, Qilu; Dong, Renfeng; Chang, Xueyi; Ren, Biye; Tong, Zhen

2015-11-11

The controlled self-assembly of self-propelled Janus micromotors may give the micromotors some potential applications in many fields. In this work, we design a kind of SiO2-Pt Janus catalytic micromotor functionalized by spiropyran (SP) moieties on the surface of the SiO2 hemisphere. The spiropyran-modified SiO2-Pt Janus micromotor exhibits autonomous self-propulsion in the presence of hydrogen peroxide fuel in N,N-dimethylformamide (DMF)/H2O (1:1 in volume) mixture. We demonstrate that the self-propelled Janus micromotors can dynamically assemble into multiple motors because of the electrostatic attractions and π-π stacking between MC molecules induced by UV light irradiation (λ = 365 nm) and also quickly disassemble into mono motors when the light is switched to green light (λ = 520 nm) for the first time. Furthermore, the assembled Janus motors can move together automatically with different motion patterns propelled by the hydrogen peroxide fuels upon UV irradiation. The work provides a new approach not only to the development of the potential application of Janus motors but also to the fundamental science of reversible self-assembly and disassembly of Janus micromotors.

Nano-functionalized filamentous fungus hyphae with fast reversible macroscopic assembly & disassembly features.

Science.gov (United States)

Wang, Haiying; Li, Xiaorui; Chai, Liyuan; Zhang, Liyuan

2015-05-18

A uniform decoration of hyphae by polyaniline nanoparticles (PANI NPs) was achieved here. This novel hybrid structure can be effectively assembled into a film by filtration and disassembled in water by shaking. This reversible process is very fast, which promises applications in nanomaterials including adsorption.

Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.

Science.gov (United States)

Nomura, Kazumi; Hayakawa, Kimihide; Tatsumi, Hitoshi; Ono, Shoichiro

2016-03-04

Actin-interacting protein 1 (AIP1) is a conserved WD repeat protein that promotes disassembly of actin filaments when actin-depolymerizing factor (ADF)/cofilin is present. Although AIP1 is known to be essential for a number of cellular events involving dynamic rearrangement of the actin cytoskeleton, the regulatory mechanism of the function of AIP1 is unknown. In this study, we report that two AIP1 isoforms from the nematode Caenorhabditis elegans, known as UNC-78 and AIPL-1, are pH-sensitive in enhancement of actin filament disassembly. Both AIP1 isoforms only weakly enhance disassembly of ADF/cofilin-bound actin filaments at an acidic pH but show stronger disassembly activity at neutral and basic pH values. However, a severing-defective mutant of UNC-78 shows pH-insensitive binding to ADF/cofilin-decorated actin filaments, suggesting that the process of filament severing or disassembly, but not filament binding, is pH-dependent. His-60 of AIP1 is located near the predicted binding surface for the ADF/cofilin-actin complex, and an H60K mutation of AIP1 partially impairs its pH sensitivity, suggesting that His-60 is involved in the pH sensor for AIP1. These biochemical results suggest that pH-dependent changes in AIP1 activity might be a novel regulatory mechanism of actin filament dynamics. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly

Directory of Open Access Journals (Sweden)

Martín Hugo

2018-06-01

Full Text Available Under oxidative stress 26S proteasomes suffer reversible disassembly into its 20S and 19S subunits, a process mediated by HSP70. This inhibits the degradation of polyubiquitinated proteins by the 26S proteasome and allows the degradation of oxidized proteins by a free 20S proteasome. Low fluxes of antimycin A-stimulated ROS production caused dimerization of mitochondrial peroxiredoxin 3 and cytosolic peroxiredoxin 2, but not peroxiredoxin overoxidation and overall oxidation of cellular protein thiols. This moderate redox imbalance was sufficient to inhibit the ATP stimulation of 26S proteasome activity. This process was dependent on reversible cysteine oxidation. Moreover, our results show that this early inhibition of ATP stimulation occurs previous to particle disassembly, indicating an intermediate step during the redox regulation of the 26S proteasome with special relevance under redox signaling rather than oxidative stress conditions.

The United States pit disassembly and conversion project -- Meeting the MOX fuel specification

International Nuclear Information System (INIS)

Nelson, T.O.; James, C.A.; Kolman, D.G.

1998-01-01

The US is actively involved in demonstrating the disassembly of nuclear weapons pits to an unclassified form readied for disposition. The MOX option is the most likely path forward for plutonium that originated from nuclear weapon pits. The US demonstration line for pit disassembly and conversion is known as ARIES, the advanced recovery and integrated extraction system. The ARIES demonstration line is being used to gather data in an integrated fashion of the technologies needed for pit disassembly and conversion. These activities include the following modules: pit bisection, hydride-dehydride, oxide conversion, canning, electrolytic decontamination, and nondestructive assay (NDA). Pit bisection swages in a pit in half. Hydride-dehydride converts the pit plutonium metal to an unclassified metal button. To convert the plutonium metal to an oxide the US is investigating a number of options. The primary oxide conversion approach involves variations of combining plutonium hydriding and subsequent oxidation. Another approach is to simply oxidize the metal under controlled conditions-direct metal oxidation (DMO). To remove the gallium from the plutonium oxide, a thermal distillation approach is being used. These pyrochemical approaches will substantially reduce the wastes produced for oxide conversion of weapon plutonium, compared to traditional aqueous processing. The packaging of either the plutonium metal or oxide to long term storage criteria involves the canning and electrolytic decontamination modules. The NDA suite of instruments is then used to assay the material in the containers, which enables international verification without the need to open the containers and repackage them. All of these processes are described

Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients

Directory of Open Access Journals (Sweden)

Adler Charles

2009-07-01

Full Text Available Abstract Correction to Nural H, He P, Beach T, Sue L, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients Molecular Neurodegeneration 2009, 4:23.

Development of disassembly and pin chopping technology for FBR spent fuels

International Nuclear Information System (INIS)

Kobayashi, Tsuguyuki; Namba, Takashi; Kawabe, Yukinari; Washiya, Tadahiro

2008-01-01

Japan Atomic Power Company (JAPC) and Japan Atomic Energy Agency (JAEA) have been developing fuel disassembly and fuel pin chopping systems for a future Japanese commercial FBR. At first, the wrapper tube is cut by the slit-cut to pull it out, then the fuel pins are cut by the crop-cut at their end-plugs to separate them from the entrance nozzle. The pins are transferred to the magazine of the chopping machine. A series of tests were performed to develop this procedure. As the result of mechanical cutting tests, the CBN wheel was selected. The slit-cut tests were carried out to evaluated the cutting performance of the wheel. The wrapper tube is normally slit-cut in the circumferential direction. One CBN wheel could cut more than 5 fuel assemblies in this direction. The slit-cut in the axial direction is prepared as provision when the tube is difficult to put out. More work is needed to cut 5mm thick PNC-FMS plate in this direction without damaging the pins beneath it. As the result of the crop-cut tests of end-plugs made of ODS steel, the CBN wheel could cut the 61 pin bundle by two strokes. More work is needed to cut the 217 pin bundle. Fuel pin handling tests were performed to transfer them from the disassembly machine to the chopping machine. The Saucer tray was selected to receive the disassembled pins. All the pins were transferred and loaded into a magazine of the chopping machine. Fuel pin loading tests were conducted to optimize the magazine configuration to make the chopping length within 1.0±0.5 cm. In order to decrease the disturbance during chopping, the width of the magazine was adjusted to be 12 cm and installation of a height adjuster is favourable to control the free space above the pins. (author)

Workshop on instrumentation of the disassembled BER II

International Nuclear Information System (INIS)

Jauch, W.; Steiner, M.

1982-01-01

A workshop on the instrumentation of a disassembled BER II-reactor took place in the Hahn-Meitner-Institute in Berlin on April 19 and 20, 1982. Invited were all groups that are promoted by the associations 'Neutron Scattering for Investigation of Condensed Substance' and 'Neutron Scattering and Complementary Methods in Chemistry and Biology', along with experts for neutron spectrometers. 40 foreign scientists from 22 different institutes had accepted the invitation. The actual questions were treated in 13 presentations and a certain number of posters, with the latter also comprising activation analysis. The present report contains the presentations submitted, the final discussion minutes and a summary from HMI-view. (orig./RW) [de

A reactor vessel and its internals disassembled and packaged

International Nuclear Information System (INIS)

Eisenmann, B.; Prechtl, E.; Suessdorf, W.

2008-01-01

2007 was a successful year for the Disassembly Unit of the Karlsruhe Research Center: dismantling the highly activated Karlsruhe Multipurpose Research Reactor (MZFR) was completed successfully and without any incident. A vote of thanks is expressed at this point to all staff members, participating industries and institutions for their extraordinary commitment and their outstanding innovation and work. Preserving and advancing existing knowledge is one of the important pillars securing a sustainable future for generations to come in Germany. Securing and advancing know-how in nuclear technology was defined as a major duty last in late January 2008 by Dr. Peter Fritz, Chairman of the Kerntechnische Gesellschaft e.V. (KTG) and member of the Executive Board of the Karlsruhe Research Center, for instance, in cooperation between the KERNTECHNIK (i.e. nuclear technology) Southwestern Research and Teaching Association and the Karlsruhe Institute of Technology (KIT). The borders of Germany do not constitute a natural radiological barrier, despite the efforts by political groups in this country to convey this impression. This report therefore is to document that the demolition of a nuclear reactor with a high radioactivity inventory can be managed safely. In the light of the experience accumulated with the MZFR, this is feasible only if demolition is carried out immediately instead of the 'problem' of disassembly and conditioning being shifted to future generations. The article is also meant to be a piece of advice by showing the unplannable difficulties which came up, and the technical solutions implemented by the competence team successfully and efficiently. (orig.)

Prey and mound disassembly, manipulation and transport by fire ant collectives

Science.gov (United States)

Dutta, Bahnisikha; Monaenkova, Daria; Goodisman, Michael A.; Goldman, Daniel

Fire ants inhabit subterranean nests covered by a hemispherical mound of soil permeated by narrow ( 1 body length diameter) tunnels. Fire ants can use their mound for long-term food storage [Gayahan &Tschinkel, J. Insect Sci.,2008]. Since mound tunnels are narrow, we expect that in addition to prey manipulation, mound reconfiguration could also be an important aspect of the food storage strategy. Ant colonies collected from wild were allowed to build nests in containers filled with clay soil in the laboratory. These colonies were offered diverse prey embedded with lead markers, including mealworms, crickets and shrimp. Ant-prey-soil interactions on the nest surface were recorded using overhead video and subsurface using x-ray imaging. Individual ants involved in prey storage exhibited three distinct behaviors: prey maneuvering, prey dissection and mound reconfiguration. Small prey (e.g. mealworms) were collectively carried intact into the mound through a tunnel, and then disassembled within the mound. Larger prey (e.g. shrimp) were dismantled into small pieces above the surface and carried to mound tunnels. The bodies of hard medium-sized prey (e.g. crickets) were buried after limb removal and then disassembled and moved into tunnels. Soil reconfiguration occurred in all cases.

Dynamic inequalities on time scales

CERN Document Server

Agarwal, Ravi; Saker, Samir

2014-01-01

This is a monograph devoted to recent research and results on dynamic inequalities on time scales. The study of dynamic inequalities on time scales has been covered extensively in the literature in recent years and has now become a major sub-field in pure and applied mathematics. In particular, this book will cover recent results on integral inequalities, including Young's inequality, Jensen's inequality, Holder's inequality, Minkowski's inequality, Steffensen's inequality, Hermite-Hadamard inequality and Čebyšv's inequality. Opial type inequalities on time scales and their extensions with weighted functions, Lyapunov type inequalities, Halanay type inequalities for dynamic equations on time scales, and Wirtinger type inequalities on time scales and their extensions will also be discussed here in detail.

Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion.

Science.gov (United States)

Liu, Linna; Li, Jing; Zhang, Liwang; Zhang, Feng; Zhang, Rong; Chen, Xiang; Brakebusch, Cord; Wang, Zhipeng; Liu, Xinyou

2015-01-01

Cytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal reorganization through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. Rac1 was knocked out in mouse keratinocytes and it was found that actin filaments disassembled. In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1). These effects were independent of the signaling pathways for p21-activated kinase/LIM kinase (Pak/LIMK), protein kinase C, or protein kinase D or generation of reactive oxygen species. Similarly, when actin polymerization was specifically inhibited or Rac1 was knocked down, cofilin phosphorylation was enhanced and SSH1 was repressed. Repression of SSH1 partially blocked actin depolymerization induced by Rac1 depletion. Therefore, aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1. © 2015 International Union of Biochemistry and Molecular Biology.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

Science.gov (United States)

Unzueta, Ugutz; Serna, Naroa; Sánchez-García, Laura; Roldán, Mónica; Sánchez-Chardi, Alejandro; Mangues, Ramón; Villaverde, Antonio; Vázquez, Esther

2017-12-01

The engineering of protein self-assembling at the nanoscale allows the generation of functional and biocompatible materials, which can be produced by easy biological fabrication. The combination of cationic and histidine-rich stretches in fusion proteins promotes oligomerization as stable protein-only regular nanoparticles that are composed by a moderate number of building blocks. Among other applications, these materials are highly appealing as tools in targeted drug delivery once empowered with peptidic ligands of cell surface receptors. In this context, we have dissected here this simple technological platform regarding the controlled disassembling and reassembling of the composing building blocks. By applying high salt and imidazole in combination, nanoparticles are disassembled in a process that is fully reversible upon removal of the disrupting agents. By taking this approach, we accomplish here the in vitro generation of hybrid nanoparticles formed by heterologous building blocks. This fact demonstrates the capability to generate multifunctional and/or multiparatopic or multispecific materials usable in nanomedical applications.

Spent fuel disassembly hardware and other non-fuel bearing components: characterization, disposal cost estimates, and proposed repository acceptance requirements

Energy Technology Data Exchange (ETDEWEB)

Luksic, A.T.; McKee, R.W.; Daling, P.M.; Konzek, G.J.; Ludwick, J.D.; Purcell, W.L.

1986-10-01

There are two categories of waste considered in this report. The first is the spent fuel disassembly (SFD) hardware. This consists of the hardware remaining after the fuel pins have been removed from the fuel assembly. This includes end fittings, spacer grids, water rods (BWR) or guide tubes (PWR) as appropriate, and assorted springs, fasteners, etc. The second category is other non-fuel-bearing (NFB) components the DOE has agreed to accept for disposal, such as control rods, fuel channels, etc., under Appendix E of the standard utiltiy contract (10 CFR 961). It is estimated that there will be approximately 150 kg of SFD and NFB waste per average metric ton of uranium (MTU) of spent uranium. PWR fuel accounts for approximately two-thirds of the average spent-fuel mass but only 50 kg of the SFD and NFB waste, with most of that being spent fuel disassembly hardware. BWR fuel accounts for one-third of the average spent-fuel mass and the remaining 100 kg of the waste. The relatively large contribution of waste hardware in BWR fuel, will be non-fuel-bearing components, primarily consisting of the fuel channels. Chapters are devoted to a description of spent fuel disassembly hardware and non-fuel assembly components, characterization of activated components, disposal considerations (regulatory requirements, economic analysis, and projected annual waste quantities), and proposed acceptance requirements for spent fuel disassembly hardware and other non-fuel assembly components at a geologic repository. The economic analysis indicates that there is a large incentive for volume reduction.

Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly

Directory of Open Access Journals (Sweden)

Danming Tang

2012-09-01

GRASP65 phosphorylation during mitosis and dephosphorylation after mitosis are required for Golgi disassembly and reassembly during the cell cycle. At least eight phosphorylation sites on GRASP65 have been identified, but whether they are modified in a coordinated fashion during mitosis is so far unknown. In this study, we raised phospho-specific antibodies that recognize phosphorylated T220/T224, S277 and S376 residues of GRASP65, respectively. Biochemical analysis showed that cdc2 phosphorylates all three sites, while plk1 enhances the phosphorylation. Microscopic studies using these antibodies for double and triple labeling demonstrate sequential phosphorylation and dephosphorylation during the cell cycle. S277 and S376 are phosphorylated from late G2 phase through metaphase until telophase when the new Golgi is reassembled. T220/224 is not modified until prophase, but is highly modified from prometaphase to anaphase. In metaphase, phospho-T220/224 signal localizes on both Golgi haze and mitotic Golgi clusters that represent dispersed Golgi vesicles and Golgi remnants, respectively, while phospho-S277 and S376 labeling is more concentrated on mitotic Golgi clusters. Expression of a phosphorylation-resistant GRASP65 mutant T220A/T224A inhibited mitotic Golgi fragmentation to a much larger extent than the expression of the S277A and S376A mutants. In cytokinesis, T220/224 dephosphorylation occurs prior to that of S277, but after S376. This study provides evidence that GRASP65 is sequentially phosphorylated and dephosphorylated during mitosis at different sites to orchestrate Golgi disassembly and reassembly during cell division, with phosphorylation of the T220/224 site being most critical in the process.

VENUS-2, Reactor Kinetics with Feedback, 2-D LMFBR Disassembly Excursions

International Nuclear Information System (INIS)

Jackson, J.F.; Nicholson, R.B.; Weber, D.P.

1980-01-01

1 - Description of problem or function: VENUS-2 is an improved edition of the VENUS fast-reactor disassembly program. It is a two- dimensional (r-z) coupled neutronics-hydrodynamics code that calculates the dynamic behavior of an LMFBR during a prompt-critical disassembly excursion. It calculates the power history and fission energy release as well as the space-time histories of the fuel temperatures, core material pressures, and core material motions. Reactivity feedback effects due to Doppler broadening and reactor material motion are taken into account. 2 - Method of solution: The power and energy release are calculated using a point-kinetics formulation with up to six delayed neutron groups. The reactivity is a combination of an input driving function and feedback effects due to Doppler broadening and material motion. An adiabatic model is used to calculate the temperature increase throughout the reactor based on an initial temperature distribution and power profile provided as input data. These temperatures are, in turn, converted to fuel pressures through one of several equation of state options provided. The material motion that results from the pressure buildup is calculated by a direct finite difference solution of a set of two-dimensional (r-z) hydrodynamics equations. This is done in Lagrangian coordinates. The reactivity change associated with this motion is calculated by first-order perturbation theory. The displacements are also used to adjust the fuel densities as required for the density dependent equation-of- state option. An automatic time-step-size selection scheme is provided. 3 - Restrictions on the complexity of the problem: VENUS-2 is written so that the dimensions of the storage arrays can be readily changed to accommodate a broad range of problem sizes. In the base version, the total number of mesh intervals is restricted such that (NR+3)*(NZ+3) is less than 700, where NR and NZ are the total number of mesh intervals in the r and z

[Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].

Science.gov (United States)

Xiao, Xu; Zhu, Ji-Xiao; Luo, Guang-Ming; Li, Lei; Zhu, Yu-Ye; Zeng, Jin-Xiang; Wang, Xiao-Yun; Wu, Bo

2013-07-01

To investigate the effect of Zhizi Baipi soup and its disassembled prescription on protecting liver and improving choleresis and explore the regularity of Zhizi Baipi soup composition. The model of mouse liver injury induced by carbon tetraehlofide (CCl4) was used to observe the effects of Zhizi Baipi soup and its disassembled prescription by oral adminstration, the bile volume was determinied by common bile duct drainage. Zhizi Baipi soup and each treatment group with gardenia could significantly inhibit the increased serum ATL and AST activities, reduce liver MDA level, and significantly promote the bile flow and bilirubin in bile in normal rats. Zhizi Baipi soup has effects on protecting liver and increasing bile secretion, its monarch drug, gardenia plays an important role in the decoction, the effect of eliminating dampness and heat are mainly ascribed to the synergic effect of gardenia and phellodendron.

Remote disassembly of radioactively contaminated vessels by means of an arc saw

International Nuclear Information System (INIS)

Beitel, G.A.

1977-01-01

The arc saw, a newly developed tool, is a toothless circular saw which cuts by means of an electric arc. Cutting speeds between 20 to 30 cm 2 /S and depths up to 45 cm are possible. There is no mechanical contact between blade and work piece, no binding, and no blade breakage. The arc saw will be applied to the rapid and remote disassembly of multiple ton, contaminated stainless steel vessels

Conceptual design report for the mechanical disassembly of Fort St. Vrain fuel elements

International Nuclear Information System (INIS)

Lord, D.L.; Wadsworth, D.C.; Sekot, J.P.; Skinner, K.L.

1993-04-01

A conceptual design study was prepared that: (1) reviewed the operations necessary to perform the mechanical disassembly of Fort St. Vrain fuel elements; (2) contained a description and survey of equipment capable of performing the necessary functions; and (3) performed a tradeoff study for determining the preferred concepts and equipment specifications. A preferred system was recommended and engineering specifications for this system were developed

Conceptual design report for the mechanical disassembly of Fort St. Vrain fuel elements

Energy Technology Data Exchange (ETDEWEB)

Lord, D.L. [Westinghouse Idaho Nuclear Co., Inc., Idaho Falls, ID (United States); Wadsworth, D.C.; Sekot, J.P.; Skinner, K.L. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

1993-04-01

A conceptual design study was prepared that: (1) reviewed the operations necessary to perform the mechanical disassembly of Fort St. Vrain fuel elements; (2) contained a description and survey of equipment capable of performing the necessary functions; and (3) performed a tradeoff study for determining the preferred concepts and equipment specifications. A preferred system was recommended and engineering specifications for this system were developed.

[PHAHs levels in soil samples from the E-waste disassembly sites and their sources allocation].

Science.gov (United States)

Zhao, Gao-Feng; Wang, Zi-Jian

2009-06-15

Soil samples (each with 3 replicates of - 1 kg, at the top 0-5 cm layer) were collected from each of the e-waste disassembly sites and the control site. Also obtained from each disassembly site were samples (each weighing - 0.2 kg) of cable coating,stuffing powder, and circuit boards chipping. The contents of 23 PBB congeners, 12 PBDE congeners, and 27 PCB congeners in soil and in their potential sources, including e-waste residues, were measured using the GC-MS5975B technique. The highest level of PBBs was found in the cable coating among the three e-waste residues, with a concentration of 35.25 ng x g(-1). The contents of low-brominated PBBs (including monobromobiphenyls and dibromobiphenyls) accounted for 38% of the total PBBs concentration observed in cable coating sample. The highest levels of PBDEs and PBDE209 were found in the stuffing powder for electronic component among the collected e-waste residues, with a concentration of 29.71 and 4.19 x 10(3) ng x g(-1). PBDE153 and PBDE183 were the most predominant PBDE congeners, with their concentration accounting for 43% and 24% of the total PBDEs concentration observed in the stuffing powder sample, respectively. Levels of PCBs in cable coating were the highest in these e-waste residues, with a concentration of 680.02 ngx g(-1). The observed values of the three PHAHs in soils from the disassembly site were considerably higher than their corresponding values observed in the control site (p < 0.05), which indicates that these PHAHs from e-waste is the pollution source of local environment.

Time Scale in Least Square Method

Directory of Open Access Journals (Sweden)

Özgür Yeniay

2014-01-01

Full Text Available Study of dynamic equations in time scale is a new area in mathematics. Time scale tries to build a bridge between real numbers and integers. Two derivatives in time scale have been introduced and called as delta and nabla derivative. Delta derivative concept is defined as forward direction, and nabla derivative concept is defined as backward direction. Within the scope of this study, we consider the method of obtaining parameters of regression equation of integer values through time scale. Therefore, we implemented least squares method according to derivative definition of time scale and obtained coefficients related to the model. Here, there exist two coefficients originating from forward and backward jump operators relevant to the same model, which are different from each other. Occurrence of such a situation is equal to total number of values of vertical deviation between regression equations and observation values of forward and backward jump operators divided by two. We also estimated coefficients for the model using ordinary least squares method. As a result, we made an introduction to least squares method on time scale. We think that time scale theory would be a new vision in least square especially when assumptions of linear regression are violated.

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status

Directory of Open Access Journals (Sweden)

Yuan Chi

2016-10-01

Full Text Available Connexin (Cx hemichannels regulate many cellular processes with little information available regarding their mechanisms. Given that many pathological factors that activate hemichannels also disrupts the integrity of cellular junctions, we speculated a potential participation of hemichannels in the regulation of cell junctions. Here we tested this hypothesis. Exposure of renal tubular epithelial cells to Ca2+-free medium led to disassembly of tight and adherens junctions, as indicated by the reduced level of ZO-1 and cadherin, disorganization of F-actin, and severe drop in transepithelial electric resistance. These changes were preceded by an activation of Cx43 hemichannels, as revealed by extracellular efflux of ATP and intracellular influx of Lucifer Yellow. Inhibition of hemichannels with chemical inhibitors or Cx43 siRNA greatly attenuated the disassembly of cell junctions. Further analysis using fetal fibroblasts derived from Cx43 wide-type (Cx43+/+, heterozygous (Cx43+/- and knockout (Cx43-/- littermates showed that Cx43-positive cells (Cx43+/+ exhibited more dramatic changes in cell shape, F-actin, and cadherin in response to Ca2+ depletion, as compared to Cx43-null cells (Cx43-/-. Consistently, these cells had higher level of protein carbonyl modification and phosphorylation, and much stronger activation of P38 and JNK. Hemichannel opening led to extracellular loss of the major antioxidant glutathione (GSH. Supplement of cells with exogenous GSH or inhibition of oxidative sensitive kinases largely prevented the above-mentioned changes. Taken together, our study indicates that Cx43 hemichannels promote the disassembly of cell junctions through regulation of intracellular oxidative status.

On the Geologic Time Scale

NARCIS (Netherlands)

Gradstein, F.M.; Ogg, J.G.; Hilgen, F.J.

2012-01-01

This report summarizes the international divisions and ages in the Geologic Time Scale, published in 2012 (GTS2012). Since 2004, when GTS2004 was detailed, major developments have taken place that directly bear and have considerable impact on the intricate science of geologic time scaling. Precam

Knowledge of damage identification about tensegrities via flexibility disassembly

Science.gov (United States)

Jiang, Ge; Feng, Xiaodong; Du, Shigui

2017-12-01

Tensegrity structures composing of continuous cables and discrete struts are under tension and compression, respectively. In order to determine the damage extents of tensegrity structures, a new method for tensegrity structural damage identification is presented based on flexibility disassembly. To decompose a tensegrity structural flexibility matrix into the matrix represention of the connectivity between degress-of-freedoms and the diagonal matrix comprising of magnitude informations. Step 1: Calculate perturbation flexibility; Step 2: Compute the flexibility connectivity matrix and perturbation flexibility parameters; Step 3: Calculate the perturbation stiffness parameters. The efficiency of the proposed method is demonstrated by a numeical example comprising of 12 cables and 4 struts with pretensioned. Accurate identification of local damage depends on the availability of good measured data, an accurate and reasonable algorithm.

Interactive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassembly.

Directory of Open Access Journals (Sweden)

Joy G Ghosh

2007-06-01

Full Text Available Small heat shock proteins regulate microtubule assembly during cell proliferation and in response to stress through interactions that are poorly understood.Novel functions for five interactive sequences in the small heat shock protein and molecular chaperone, human alphaB crystallin, were investigated in the assembly/disassembly of microtubules and aggregation of tubulin using synthetic peptides and mutants of human alphaB crystallin.The interactive sequence (113FISREFHR(120 exposed on the surface of alphaB crystallin decreased microtubule assembly by approximately 45%. In contrast, the interactive sequences, (131LTITSSLSSDGV(142 and (156ERTIPITRE(164, corresponding to the beta8 strand and the C-terminal extension respectively, which are involved in complex formation, increased microtubule assembly by approximately 34-45%. The alphaB crystallin peptides, (113FISREFHR(120 and (156ERTIPITRE(164, inhibited microtubule disassembly by approximately 26-36%, and the peptides (113FISREFHR(120 and (131LTITSSLSSDGV(142 decreased the thermal aggregation of tubulin by approximately 42-44%. The (131LTITSSLSSDGV(142 and (156ERTIPITRE(164 peptides were more effective than the widely used anti-cancer drug, Paclitaxel, in modulating tubulinmicrotubule dynamics. Mutagenesis of these interactive sequences in wt human alphaB crystallin confirmed the effects of the alphaB crystallin peptides on microtubule assembly/disassembly and tubulin aggregation. The regulation of microtubule assembly by alphaB crystallin varied over a narrow range of concentrations. The assembly of microtubules was maximal at alphaB crystallin to tubulin molar ratios between 1:4 and 2:1, while molar ratios >2:1 inhibited microtubule assembly.Interactive sequences on the surface of human alphaB crystallin collectively modulate microtubule assembly through a dynamic subunit exchange mechanism that depends on the concentration and ratio of alphaB crystallin to tubulin. These are the first

Polygons and adhesion plaques and the disassembly and assembly of myofibrils in cardiac myocytes.

Science.gov (United States)

Lin, Z X; Holtzer, S; Schultheiss, T; Murray, J; Masaki, T; Fischman, D A; Holtzer, H

1989-06-01

Successive stages in the disassembly of myofibrils and the subsequent assembly of new myofibrils have been studied in cultures of dissociated chick cardiac myocytes. The myofibrils in trypsinized and dispersed myocytes are sequentially disassembled during the first 3 d of culture. They split longitudinally and then assemble into transitory polygons. Multiples of single sarcomeres, the cardiac polygons, are analogous to the transitory polygonal configurations assumed by stress fibers in spreading fibroblasts. They differ from their counterparts in fibroblasts in that they consist of muscle alpha-actinin vertices and muscle myosin heavy chain struts, rather than of the nonmuscle contractile protein isoforms of stress fiber polygons. EM sections reveal the vertices and struts in cardiac polygons to be typical Z and A bands. Most cardiac polygons are eliminated by day 5 of culture. Concurrent with the disassembly and elimination of the original myofibrils new myofibrils are rapidly assembled elsewhere in the same myocyte. Without exception both distal tips of each nascent myofibril terminate in adhesion plaques. The morphology and composition of the adhesion plaques capping each end of each myofibril are similar to those of the termini of stress fibers in fibroblasts. However, whereas the adhesion complexes involving stress fibers in fibroblasts consist of vinculin/nonmuscle alpha-actinin/beta- and gamma-actins, the analogous structures in myocytes involving myofibrils consist of vinculin/muscle alpha-actinin/alpha-actin. The addition of 1.7-2.0 microns sarcomeres to the distal tips of an elongating myofibril, irrespective of whether the myofibril consists of 1, 10, or several hundred tandem sarcomeres, occurs while the myofibril appears to remain linked to its respective adhesion plaques. The adhesion plaques in vitro are the equivalent of the in vivo intercalated discs, both in terms of their molecular composition and with respect to their functioning as initiating

Multiple time scale methods in tokamak magnetohydrodynamics

International Nuclear Information System (INIS)

Jardin, S.C.

1984-01-01

Several methods are discussed for integrating the magnetohydrodynamic (MHD) equations in tokamak systems on other than the fastest time scale. The dynamical grid method for simulating ideal MHD instabilities utilizes a natural nonorthogonal time-dependent coordinate transformation based on the magnetic field lines. The coordinate transformation is chosen to be free of the fast time scale motion itself, and to yield a relatively simple scalar equation for the total pressure, P = p + B 2 /2μ 0 , which can be integrated implicitly to average over the fast time scale oscillations. Two methods are described for the resistive time scale. The zero-mass method uses a reduced set of two-fluid transport equations obtained by expanding in the inverse magnetic Reynolds number, and in the small ratio of perpendicular to parallel mobilities and thermal conductivities. The momentum equation becomes a constraint equation that forces the pressure and magnetic fields and currents to remain in force balance equilibrium as they evolve. The large mass method artificially scales up the ion mass and viscosity, thereby reducing the severe time scale disparity between wavelike and diffusionlike phenomena, but not changing the resistive time scale behavior. Other methods addressing the intermediate time scales are discussed

Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform

International Nuclear Information System (INIS)

Gallagher, John R.; Torian, Udana; McCraw, Dustin M.; Harris, Audray K.

2017-01-01

While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. One such particle is the hepatitis B virus surface antigen (sAg) that exists as nanoparticles. Here we show, using biochemical analysis coupled with electron microscopy, that sAg nanoparticle disassembly requires both reducing agent to disrupt intermolecular disulfide bonds, and detergent to disrupt hydrophobic interactions that stabilize the nanoparticle. Particles were otherwise resistant to salt and urea, suggesting the driving mechanism of particle formation involves hydrophobic interactions. We reassembled isolated sAg protein into nanoparticles by detergent removal and reassembly resulted in a wider distribution of particle diameters. Knowledge of these driving forces of nanoparticle assembly and stability should facilitate construction of epitope-displaying nanoparticles that can be used as immunogens in vaccines.

Characterization of the disassembly and reassembly of the HBV glycoprotein surface antigen, a pliable nanoparticle vaccine platform

Energy Technology Data Exchange (ETDEWEB)

Gallagher, John R.; Torian, Udana; McCraw, Dustin M.; Harris, Audray K., E-mail: harrisau@mail.nih.gov

2017-02-15

While nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. One such particle is the hepatitis B virus surface antigen (sAg) that exists as nanoparticles. Here we show, using biochemical analysis coupled with electron microscopy, that sAg nanoparticle disassembly requires both reducing agent to disrupt intermolecular disulfide bonds, and detergent to disrupt hydrophobic interactions that stabilize the nanoparticle. Particles were otherwise resistant to salt and urea, suggesting the driving mechanism of particle formation involves hydrophobic interactions. We reassembled isolated sAg protein into nanoparticles by detergent removal and reassembly resulted in a wider distribution of particle diameters. Knowledge of these driving forces of nanoparticle assembly and stability should facilitate construction of epitope-displaying nanoparticles that can be used as immunogens in vaccines.

Underwater Nuclear Fuel Disassembly and Rod Storage Process and Equipment Description. Volume II

International Nuclear Information System (INIS)

Viebrock, J.M.

1981-09-01

The process, equipment, and the demonstration of the Underwater Nuclear Fuel Disassembly and Rod Storage System are presented. The process was shown to be a viable means of increasing spent fuel pool storage density by taking apart fuel assemblies and storing the fuel rods in a denser fashion than in the original storage racks. The assembly's nonfuel-bearing waste is compacted and containerized. The report documents design criteria and analysis, fabrication, demonstration program results, and proposed enhancements to the system

Assessment of the impacts of spent fuel disassembly alternatives on the Nuclear Waste Isolation System

International Nuclear Information System (INIS)

1984-07-01

The objective of this report was to evaluate four possible alternative methods of preparing and packaging spent fuel assemblies for geologic disposal against the Reference Process of unmodified spent fuel. The four alternative processes were: (1) End fitting removal, (2) Fission gas venting and resealing, (3) Fuel bundle disassembly and close packing of fuel pins, and (4) Fuel shearing and immobilization. Systems analysis was used to develop a basis of comparison of the alternatives. Conceptual processes and facility layouts were devised for each of the alternatives, based on technology deemed feasible for the purpose. Assessments were made of 15 principal attributes from the technical, operational, safety/risk, and economic considerations related to each of the alternatives, including both the surface packaging and underground repository operations. Specific attributes of the alternative processes were evaluated by assigning a number for each that expressed its merit relative to the corresponding attribute of the Reference Process. Each alternative process was then ranked by summing the numbers for attributes in each of the four assessment areas and collectively. Fuel bundle disassembly and close packing of fuel pins was ranked the preferred method of disposal of spent fuel. 63 references, 46 figures, 46 tables

Stochastic time scale for the Universe

International Nuclear Information System (INIS)

Szydlowski, M.; Golda, Z.

1986-01-01

An intrinsic time scale is naturally defined within stochastic gradient dynamical systems. It should be interpreted as a ''relaxation time'' to a local potential minimum after the system has been randomly perturbed. It is shown that for a flat Friedman-like cosmological model this time scale is of order of the age of the Universe. 7 refs. (author)

Pair plasma relaxation time scales.

Science.gov (United States)

Aksenov, A G; Ruffini, R; Vereshchagin, G V

2010-04-01

By numerically solving the relativistic Boltzmann equations, we compute the time scale for relaxation to thermal equilibrium for an optically thick electron-positron plasma with baryon loading. We focus on the time scales of electromagnetic interactions. The collisional integrals are obtained directly from the corresponding QED matrix elements. Thermalization time scales are computed for a wide range of values of both the total-energy density (over 10 orders of magnitude) and of the baryonic loading parameter (over 6 orders of magnitude). This also allows us to study such interesting limiting cases as the almost purely electron-positron plasma or electron-proton plasma as well as intermediate cases. These results appear to be important both for laboratory experiments aimed at generating optically thick pair plasmas as well as for astrophysical models in which electron-positron pair plasmas play a relevant role.

Innovation and employee injury risk in automotive disassembly operations

DEFF Research Database (Denmark)

Neumann, W. Patrick; Winkel, Jørgen; Palmerud, Gunnar

2018-01-01

to control injury hazards as part of the development and design process. These cases suggest how failure to manage RSI hazards in the innovation process may allow increases of injury risks that can compromise operational performance. This ‘innovation pitfall’ has implications for operator health...... increased movement speeds and reduced muscular recovery opportunities, implying increased RSI risk. This case study reveals a mechanism by which innovation may increase RSI risks for operators. Managers responsible for engineering innovation should ensure their teams have the tools and mandate necessary......Engineering innovations in car disassembly systems are studied for affects on system operators’ risk of repetitive strain injury (RSI). Objective instrumented measures of injury risk factors with synchronised video-based task analyses were used to examine changes in operators’ RSI risk during...

Disassembly Control of Saccharide-Based Amphiphiles Driven by Electrostatic Repulsion.

Science.gov (United States)

Yamada, Taihei; Kokado, Kenta; Sada, Kazuki

2017-03-14

According to the design of disassembly using electrostatic repulsion, novel amphiphiles consisting of a lipophilic ion part and a hydrophilic saccharide part were synthesized via the facile copper-catalyzed click reaction, and their molecular assemblies in water and chloroform were studied. The amphiphiles exhibited a molecular orientation opposite to that of the conventional amphiphiles in each case. ζ Potential measurements indicated that the lipophilic ion part is exposed outside in chloroform. The size of a solvophobic part in the amphiphiles dominates the size of an assembling structure; that is, in water, these amphiphiles tethering different lengths of the saccharide part exhibited almost identical assembling size, whereas in chloroform, the size depends on the length of the saccharide part in the amphiphiles.

Hardy type inequalities on time scales

CERN Document Server

Agarwal, Ravi P; Saker, Samir H

2016-01-01

The book is devoted to dynamic inequalities of Hardy type and extensions and generalizations via convexity on a time scale T. In particular, the book contains the time scale versions of classical Hardy type inequalities, Hardy and Littlewood type inequalities, Hardy-Knopp type inequalities via convexity, Copson type inequalities, Copson-Beesack type inequalities, Liendeler type inequalities, Levinson type inequalities and Pachpatte type inequalities, Bennett type inequalities, Chan type inequalities, and Hardy type inequalities with two different weight functions. These dynamic inequalities contain the classical continuous and discrete inequalities as special cases when T = R and T = N and can be extended to different types of inequalities on different time scales such as T = hN, h > 0, T = qN for q > 1, etc.In this book the authors followed the history and development of these inequalities. Each section in self-contained and one can see the relationship between the time scale versions of the inequalities and...

Time scales in tidal disruption events

Directory of Open Access Journals (Sweden)

Krolik J.

2012-12-01

Full Text Available We explore the temporal structure of tidal disruption events pointing out the corresponding transitions in the lightcurves of the thermal accretion disk and of the jet emerging from such events. The hydrodynamic time scale of the disrupted star is the minimal time scale of building up the accretion disk and the jet and it sets a limit on the rise time. This suggest that Swift J1644+57, that shows several flares with a rise time as short as a few hundred seconds could not have arisen from a tidal disruption of a main sequence star whose hydrodynamic time is a few hours. The disrupted object must have been a white dwarf. A second important time scale is the Eddington time in which the accretion rate changes form super to sub Eddington. It is possible that such a transition was observed in the light curve of Swift J2058+05. If correct this provides interesting constraints on the parameters of the system.

T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells.

Directory of Open Access Journals (Sweden)

Yosuke Masubuchi

Full Text Available We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulation of this receptor with sucralose or saccharin induced disassembly of the microtubules in 3T3-L1 preadipocytes, which was attenuated by overexpression of the dominant-negative mutant of Gαs (Gαs-G226A. In contrast, overexpression of the constitutively active mutant of Gαs (Gαs-Q227L as well as treatment with cholera toxin or isoproterenol but not with forskolin caused disassembly of the microtubules. Sweetener-induced microtubule disassembly was accompanied by activation of RhoA and Rho-associated kinase (ROCK. This was attenuated with by knockdown of GEF-H1, a microtubule-localized guanine nucleotide exchange factor for Rho GTPase. Furthermore, overexpression of the dominant-negative mutant of RhoA (RhoA-T19N blocked sweetener-induced dephosphorylation of Akt and repression of PPARγ and C/EBPα in the early phase of adipogenic differentiation. These results suggest that the T1R3 homomeric sweet taste receptor negatively regulates adipogenesis through Gαs-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway.

Systems impacts of spent fuel disassembly alternatives

International Nuclear Information System (INIS)

1984-07-01

Three studies were completed to evaluate four alternatives to the disposal of intact spent fuel assemblies in a geologic repository. A preferred spent fuel waste form for disposal was recommended on consideration of (1) package design and fuel/package interaction, (2) long-term, in-repository performance of the waste form, and (3) overall process performance and costs for packaging, handling, and emplacement. The four basic alternative waste forms considered were (1) end fitting removal, (2) fission gas venting, (3) disassembly and close packing, and (4) shearing/immobilization. None of the findings ruled out any alternative on the basis of waste package considerations or long-term performance of the waste form. The third alternative offers flexibility in loading that may prove attractive in the various geologic media under consideration, greatly reduces the number of packages, and has the lowest unit cost. These studies were completed in October, 1981. Since then Westinghouse Electric Corporation and the Office of Nuclear Waste Isolation have completed studies in related fields. This report is now being published to provide publicly the background material that is contained within. 47 references, 28 figures, 31 tables

The development of underwater remote cutting method for the disassembling of rotary specimen rack KRR-1 and 2

Energy Technology Data Exchange (ETDEWEB)

Lee, D. K.; Jung, K. H.; Lee, K. W.; Oh, W. J. [KAERI, Taejon (Korea, Republic of); Lee, K. Y. [Korea Institute of Industrial Technology, Kwangju (Korea, Republic of)

2004-07-01

The Rotary Specimen Racks (RSRs) were highly activated and then classified intermediate level radioactive waste for the decommissioning of KRR-1anel2. The RSR can be treated as low level radioactive waste after removing stainless steel parts. To reduce the volume of intermediate level radioactive waste, underwater cutting is required to separate stainless steel parts from RSR because of high radioactivity. In this study, the automatic remote cutting method was developed to disassemble RSR under water. For automatic remote cutting processes, a CAM (Computer Aided Manufacturing) system is employed. A computer inputs NC (Numerical Control) codes to the controller, which are based on CAM model, and the controller instructs the equipment to process according to NC codes automatically. And the cutting force model was improved to cut RSR stably. The automatic cutting was conducted using imitation of RSR and then it was resulted that the developed automatic cutting method can be safely disassemble stainless steel parts of RSR under water.

Uniform Statistical Convergence on Time Scales

Directory of Open Access Journals (Sweden)

Yavuz Altin

2014-01-01

Full Text Available We will introduce the concept of m- and (λ,m-uniform density of a set and m- and (λ,m-uniform statistical convergence on an arbitrary time scale. However, we will define m-uniform Cauchy function on a time scale. Furthermore, some relations about these new notions are also obtained.

Maintenance and disassembly considerations for the Technology Demonstration Facility

International Nuclear Information System (INIS)

Spampinato, P.T.

1983-01-01

The Technology Demonstration Facility (TDF) is a tandem-mirror design concept carried out under the direction of Lawrence Livermore National Laboratory. It was conceived as a near-term device with a mission of developing engineering technology in a D-T fusion environment. Overall maintenance and component disassembly were among the responsibilities of the Fusion Engineering Design Center (FEDC). A configuration evolved that was based on the operational requirements of the components, as well as the requirements for their replacements. Component lifetime estimates were used to estimate the frequency and the number of replacements. In addition, it was determined that the need for remote handling equipment followed within 1.5 years after initial start-up, emphasizing the direct relationship between developing maintenance scenarios/equipment and the device configuration. Many of the scheduled maintenance operations were investigated to first order, and preliminary handling equipment concepts were developed

Plastics disassembly versus bulk recycling: engineering design for end-of-life electronics resource recovery.

Science.gov (United States)

Rios, Pedro; Stuart, Julie Ann; Grant, Ed

2003-12-01

Annual plastic flows through the business and consumer electronics manufacturing supply chain include nearly 3 billion lb of high-value engineering plastics derived from petroleum. The recovery of resource value from this stream presents critical challenges in areas of materials identification and recycling process design that demand new green engineering technologies applied together with life cycle assessment and ecological supply chain analysis to create viable plastics-to-plastics supply cycles. The sustainable recovery of potentially high-value engineering plastics streams requires that recyclers either avoid mixing plastic parts or purify later by separating smaller plastic pieces created in volume reduction (shredding) steps. Identification and separation constitute significant barriers in the plastics-to-plastics recycling value proposition. In the present work, we develop a model that accepts randomly arriving electronic products to study scenarios by which a recycler might identify and separate high-value engineering plastics as well as metals. Using discrete eventsimulation,we compare current mixed plastics recovery with spectrochemical plastic resin identification and subsequent sorting. Our results show that limited disassembly with whole-part identification can produce substantial yields in separated streams of recovered engineering thermoplastics. We find that disassembly with identification does not constitute a bottleneck, but rather, with relatively few workers, can be configured to pull the process and thus decrease maximum staging space requirements.

Full-scale and time-scale heating experiments at Stripa: preliminary results

International Nuclear Information System (INIS)

Cook, N.G.W.; Hood, Michael; California Univ., Berkeley

1978-01-01

Two full-scale heating experiments and a time-scale heating experiment have recently been started in granite 340 meters below surface. The purpose of the full-scale heating experiments is to assess the near-field effects of thermal loading for the design of an underground repository of nuclear wastes. That of the time-scale heating experiments is to obtain field data of the interaction between heaters and its effect on the rock mass during a period of about two years, which corresponds to about twenty years of full-scale operation. Geological features of the rock around each experiment have been mapped carefully, and temperatures, stresses and displacements induced in the rock by heating have been calculated in advance of the experiments. Some 800 different measurements are recorded at frequent intervals by a computer system situated underground. These data can be compared at any time with predictions made earlier on video display units underground

Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography

Science.gov (United States)

Kim, Chang Soo; Ingato, Dominique; Wilder-Smith, Petra; Chen, Zhongping; Kwon, Young Jik

2018-01-01

A key design consideration in developing contrast agents is obtaining distinct, multiple signal changes in diseased tissue. Plasmonic gold nanoparticles (Au NPs) have been developed as contrast agents due to their strong surface plasmon resonance (SPR). This study aims to demonstrate that stimuli-responsive plasmonic Au nanoclusters (Au NCs) can be used as a contrast agent for optical coherence tomography (OCT) in detecting early-stage cancer. Au NPs were clustered via acid-cleavable linkers to synthesize Au NCs that disassemble under mildly acidic conditions into individual Au NPs, simultaneously diminishing SPR effect (quantified by scattering intensity) and increasing Brownian motion (quantified by Doppler variance). The acid-triggered morphological and accompanying optico-physical property changes of the acid-disassembling Au NCs were confirmed by TEM, DLS, UV/Vis, and OCT. Stimuli-responsive Au NCs were applied in a hamster check pouch model carrying early-stage squamous carcinoma tissue. The tissue was visualized by OCT imaging, which showed reduced scattering intensity and increased Doppler variance in the dysplastic tissue. This study demonstrates the promise of diagnosing early-stage cancer using molecularly programmable, inorganic nanomaterial-based contrast agents that are capable of generating multiple, stimuli-triggered diagnostic signals in early-stage cancer.[Figure not available: see fulltext.

Technical review of WSRC-TR-93-614 criticality safety evaluation for disassembly basin sand filter

International Nuclear Information System (INIS)

Reed, R.L.

1994-01-01

The study documented in WSRC-TR-93-614 performed an evaluation of the criticality potential associated with the Disassembly Basin Sand Filter for K and L Areas. The document reviewed incorporated results of calculations documented in the engineering calculation N-CLC-K-00151. Analyses of the contents of disassembly basin sludge has indicated that the sludge contains fissile material in excess of subcritical mass limits as specified in ANSI/ANS standards. Previous studies had determined that the fissile material can not collect into a critical configuration in the basin. Since the sand filter is intended to remove suspended particles from the basin water and could serve as a mechanism to collect the fissile material into a critical configuration, the study examined conditions under which criticality could occur in the sand filter. The study shows that criticality is not considered possible in the sand filter. This review emphasized the technical accuracy and presentation of the evaluation. The evaluation was also examined for the elements required for NCSEs. The review was performed in accordance with the NRTSC technical review requirements and procedures and the E7 Manual technical review requirements. The technical review (per the E7 manual) of the engineering calculation (N-CLC-K-0 1 5 1) was previously performed by this reviewer

Multiple time scale dynamics

CERN Document Server

Kuehn, Christian

2015-01-01

This book provides an introduction to dynamical systems with multiple time scales. The approach it takes is to provide an overview of key areas, particularly topics that are less available in the introductory form.  The broad range of topics included makes it accessible for students and researchers new to the field to gain a quick and thorough overview. The first of its kind, this book merges a wide variety of different mathematical techniques into a more unified framework. The book is highly illustrated with many examples and exercises and an extensive bibliography. The target audience of this  book are senior undergraduates, graduate students as well as researchers interested in using the multiple time scale dynamics theory in nonlinear science, either from a theoretical or a mathematical modeling perspective. 

Russian national time scale long-term stability

Science.gov (United States)

Alshina, A. P.; Gaigerov, B. A.; Koshelyaevsky, N. B.; Pushkin, S. B.

1994-05-01

The Institute of Metrology for Time and Space NPO 'VNIIFTRI' generates the National Time Scale (NTS) of Russia -- one of the most stable time scales in the world. Its striking feature is that it is based on a free ensemble of H-masers only. During last two years the estimations of NTS longterm stability based only on H-maser intercomparison data gives a flicker floor of about (2 to 3) x 10(exp -15) for averaging times from 1 day to 1 month. Perhaps the most significant feature for a time laboratory is an extremely low possible frequency drift -- it is too difficult to estimate it reliably. The other estimations, free from possible inside the ensemble correlation phenomena, are available based on the time comparison of NTS relative to the stable enough time scale of outer laboratories. The data on NTS comparison relative to the time scale of secondary time and frequency standards at Golitzino and Irkutsk in Russia and relative to NIST, PTB and USNO using GLONASS and GPS time transfer links gives stability estimations which are close to that based on H-maser intercomparisons.

Cesium removal from the fuel storage water at the Savannah River Site R-Building Disassembly Basin using 3M Empore reg-sign-membrane filter technology

International Nuclear Information System (INIS)

Oji, L.N.; Thompson, M.C.; Peterson, K.; May, C.; Kafka, T.M.

1998-01-01

This report describes results from a seven-day demonstration of the use of 3M Empore membrane filter loaded with ion exchange material (potassium cobalt hexacynoferrate (CoHex)) for cesium uptake from the R-Disassembly Basin at the Savannah River Site. The goal of the demonstration was to evaluate the ability of the Process Absorber Development unit (PADU), a water pre-filtration /CoHex configuration on a skid, to remove cesium from R-Disassembly Basin at a linear processing flow rate of 22.7 liters per minute (1,195.8 liters/minute/m 2 or 29.35 gallons/minute/ft 2 ). Over 210,000 liters (> 55,500 gallons) of R-Disassembly Basin water was processed through the PADU without a cesium breakthrough, that is, the effluent after treatment with CoHex, contained less than detectable amounts of radioactive cesium. Some of the observed advantages of the Empore membrane filter technology over conventional packed column ion exchange systems includes rapid flow rates without channeling effects, low volume secondary waste and fast extraction or rapid kinetics per unit of flow

Mouse Activity across Time Scales: Fractal Scenarios

Science.gov (United States)

Lima, G. Z. dos Santos; Lobão-Soares, B.; do Nascimento, G. C.; França, Arthur S. C.; Muratori, L.; Ribeiro, S.; Corso, G.

2014-01-01

In this work we devise a classification of mouse activity patterns based on accelerometer data using Detrended Fluctuation Analysis. We use two characteristic mouse behavioural states as benchmarks in this study: waking in free activity and slow-wave sleep (SWS). In both situations we find roughly the same pattern: for short time intervals we observe high correlation in activity - a typical 1/f complex pattern - while for large time intervals there is anti-correlation. High correlation of short intervals ( to : waking state and to : SWS) is related to highly coordinated muscle activity. In the waking state we associate high correlation both to muscle activity and to mouse stereotyped movements (grooming, waking, etc.). On the other side, the observed anti-correlation over large time scales ( to : waking state and to : SWS) during SWS appears related to a feedback autonomic response. The transition from correlated regime at short scales to an anti-correlated regime at large scales during SWS is given by the respiratory cycle interval, while during the waking state this transition occurs at the time scale corresponding to the duration of the stereotyped mouse movements. Furthermore, we find that the waking state is characterized by longer time scales than SWS and by a softer transition from correlation to anti-correlation. Moreover, this soft transition in the waking state encompass a behavioural time scale window that gives rise to a multifractal pattern. We believe that the observed multifractality in mouse activity is formed by the integration of several stereotyped movements each one with a characteristic time correlation. Finally, we compare scaling properties of body acceleration fluctuation time series during sleep and wake periods for healthy mice. Interestingly, differences between sleep and wake in the scaling exponents are comparable to previous works regarding human heartbeat. Complementarily, the nature of these sleep-wake dynamics could lead to a better

Scale-dependent intrinsic entropies of complex time series.

Science.gov (United States)

Yeh, Jia-Rong; Peng, Chung-Kang; Huang, Norden E

2016-04-13

Multi-scale entropy (MSE) was developed as a measure of complexity for complex time series, and it has been applied widely in recent years. The MSE algorithm is based on the assumption that biological systems possess the ability to adapt and function in an ever-changing environment, and these systems need to operate across multiple temporal and spatial scales, such that their complexity is also multi-scale and hierarchical. Here, we present a systematic approach to apply the empirical mode decomposition algorithm, which can detrend time series on various time scales, prior to analysing a signal's complexity by measuring the irregularity of its dynamics on multiple time scales. Simulated time series of fractal Gaussian noise and human heartbeat time series were used to study the performance of this new approach. We show that our method can successfully quantify the fractal properties of the simulated time series and can accurately distinguish modulations in human heartbeat time series in health and disease. © 2016 The Author(s).

Soil moisture memory at sub-monthly time scales

Science.gov (United States)

Mccoll, K. A.; Entekhabi, D.

2017-12-01

For soil moisture-climate feedbacks to occur, the soil moisture storage must have `memory' of past atmospheric anomalies. Quantifying soil moisture memory is, therefore, essential for mapping and characterizing land-atmosphere interactions globally. Most previous studies estimate soil moisture memory using metrics based on the autocorrelation function of the soil moisture time series (e.g., the e-folding autocorrelation time scale). This approach was first justified by Delworth and Manabe (1988) on the assumption that monthly soil moisture time series can be modelled as red noise. While this is a reasonable model for monthly soil moisture averages, at sub-monthly scales, the model is insufficient due to the highly non-Gaussian behavior of the precipitation forcing. Recent studies have shown that significant soil moisture-climate feedbacks appear to occur at sub-monthly time scales. Therefore, alternative metrics are required for defining and estimating soil moisture memory at these shorter time scales. In this study, we introduce metrics, based on the positive and negative increments of the soil moisture time series, that can be used to estimate soil moisture memory at sub-monthly time scales. The positive increments metric corresponds to a rapid drainage time scale. The negative increments metric represents a slower drying time scale that is most relevant to the study of land-atmosphere interactions. We show that autocorrelation-based metrics mix the two time scales, confounding physical interpretation. The new metrics are used to estimate soil moisture memory at sub-monthly scales from in-situ and satellite observations of soil moisture. Reference: Delworth, Thomas L., and Syukuro Manabe. "The Influence of Potential Evaporation on the Variabilities of Simulated Soil Wetness and Climate." Journal of Climate 1, no. 5 (May 1, 1988): 523-47. doi:10.1175/1520-0442(1988)0012.0.CO;2.

Introductory Education for Mechanical Engineering by Exercise in Mechanical Disassembly

Science.gov (United States)

Matsui, Yoshio; Asakawa, Naoki; Iwamori, Satoru

An introductory program “Exercise for engineers in mechanical disassembly” is an exercise that ten students of every team disassemble a motor scooter to the components and then assemble again to the initial form in 15 weeks. The purpose of this program is to introduce mechanical engineering by touching the real machine and learning how it is composed from various mechanical parts to the students at the early period after the entrance into the university. Additional short lectures by young teachers and a special lecture by a top engineer in the industry encourage the students to combine the actual machine and the mechanical engineering subjects. Furthermore, various educations such as group leader system, hazard prediction training, parts filing are included in this program. As a result, students recognize the importance of the mechanical engineering study and the way of group working.

Some nonlinear dynamic inequalities on time scales

Indian Academy of Sciences (India)

In 1988, Stefan Hilger [10] introduced the calculus on time scales which unifies continuous and discrete analysis. Since then many authors have expounded on various aspects of the theory of dynamic equations on time scales. Recently, there has been much research activity concerning the new theory. For example, we ...

Almost Automorphic Functions on the Quantum Time Scale and Applications

Directory of Open Access Journals (Sweden)

Yongkun Li

2017-01-01

Full Text Available We first propose two types of concepts of almost automorphic functions on the quantum time scale. Secondly, we study some basic properties of almost automorphic functions on the quantum time scale. Then, we introduce a transformation between functions defined on the quantum time scale and functions defined on the set of generalized integer numbers; by using this transformation we give equivalent definitions of almost automorphic functions on the quantum time scale; following the idea of the transformation, we also give a concept of almost automorphic functions on more general time scales that can unify the concepts of almost automorphic functions on almost periodic time scales and on the quantum time scale. Finally, as an application of our results, we establish the existence of almost automorphic solutions of linear and semilinear dynamic equations on the quantum time scale.

KADIS: a program to analyse the disassembly phase of hypothetical accidents in LMFBRs

International Nuclear Information System (INIS)

Schmuck, P.; Jacobs, G.; Arnecke, G.

1977-11-01

The program KADIS models the disassembly phase during power excursions in LMFBR hypothetical accidents. KADIS is based on point kinetics in the neutronics part and on a 2-dimensional representation of the reactor core in the hydrodynamics part. The core is modeled as an ideal, compressible fluid which is heated up adiabatically during the excursion. KADIS was built up with the help of the VENUS program of Argonne National Laboratory. Several important features were added to the basic VENUS model. Therefore we give first a complete description of the mathematical models used. Secondly we provide the user with the necessary information to handle the input/output of KADIS. (orig.) [de

A laboratory scale fundamental time?

International Nuclear Information System (INIS)

Mendes, R.V.

2012-01-01

The existence of a fundamental time (or fundamental length) has been conjectured in many contexts. However, the ''stability of physical theories principle'' seems to be the one that provides, through the tools of algebraic deformation theory, an unambiguous derivation of the stable structures that Nature might have chosen for its algebraic framework. It is well-known that c and ℎ are the deformation parameters that stabilize the Galilean and the Poisson algebra. When the stability principle is applied to the Poincare-Heisenberg algebra, two deformation parameters emerge which define two time (or length) scales. In addition there are, for each of them, a plus or minus sign possibility in the relevant commutators. One of the deformation length scales, related to non-commutativity of momenta, is probably related to the Planck length scale but the other might be much larger and already detectable in laboratory experiments. In this paper, this is used as a working hypothesis to look for physical effects that might settle this question. Phase-space modifications, resonances, interference, electron spin resonance and non-commutative QED are considered. (orig.)

Multivariable dynamic calculus on time scales

CERN Document Server

Bohner, Martin

2016-01-01

This book offers the reader an overview of recent developments of multivariable dynamic calculus on time scales, taking readers beyond the traditional calculus texts. Covering topics from parameter-dependent integrals to partial differentiation on time scales, the book’s nine pedagogically oriented chapters provide a pathway to this active area of research that will appeal to students and researchers in mathematics and the physical sciences. The authors present a clear and well-organized treatment of the concept behind the mathematics and solution techniques, including many practical examples and exercises.

Nuclear disassembly of the (Pb+Au) system at Elab=29 MeV per nucleon

International Nuclear Information System (INIS)

Piasecki, E.; Kordyasz, A.; Bresson, S.; Crema, E.; Galin, J.; Guerreau, D.; Morjean, M.; Paulot, C.; Pouthas, J.; Jastrzebski, J.; Pienkowski, L.; Skulski, W.; Lott, B.; Quednau, B.; Schroder, W.U.; Toeke, J.

1990-01-01

Nuclei, with Z up to 82, emitted in the 208 Pb+ 197 Au reaction at E lab =29 MeV per nucleon, have been measured as a function of the associated neutron multiplicity. The data reveal the presence of strong correlations between character of a collision and neutron multiplicity. The trends suggest a disassembly of the nuclear system into a large number of nucleons and small fragments in the events with the highest neutron multiplicity. In such events, approximately one third of the neutrons are released from the system and fragments yields decrease in an exponential fashion with increasing mass

Liquidity crises on different time scales

Science.gov (United States)

Corradi, Francesco; Zaccaria, Andrea; Pietronero, Luciano

2015-12-01

We present an empirical analysis of the microstructure of financial markets and, in particular, of the static and dynamic properties of liquidity. We find that on relatively large time scales (15 min) large price fluctuations are connected to the failure of the subtle mechanism of compensation between the flows of market and limit orders: in other words, the missed revelation of the latent order book breaks the dynamical equilibrium between the flows, triggering the large price jumps. On smaller time scales (30 s), instead, the static depletion of the limit order book is an indicator of an intrinsic fragility of the system, which is related to a strongly nonlinear enhancement of the response. In order to quantify this phenomenon we introduce a measure of the liquidity imbalance present in the book and we show that it is correlated to both the sign and the magnitude of the next price movement. These findings provide a quantitative definition of the effective liquidity, which proves to be strongly dependent on the considered time scales.

Time scale algorithm: Definition of ensemble time and possible uses of the Kalman filter

Science.gov (United States)

Tavella, Patrizia; Thomas, Claudine

1990-01-01

The comparative study of two time scale algorithms, devised to satisfy different but related requirements, is presented. They are ALGOS(BIPM), producing the international reference TAI at the Bureau International des Poids et Mesures, and AT1(NIST), generating the real-time time scale AT1 at the National Institute of Standards and Technology. In each case, the time scale is a weighted average of clock readings, but the weight determination and the frequency prediction are different because they are adapted to different purposes. The possibility of using a mathematical tool, such as the Kalman filter, together with the definition of the time scale as a weighted average, is also analyzed. Results obtained by simulation are presented.

Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

KAUST Repository

Li, Song

2015-04-27

Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Physical time scale in kinetic Monte Carlo simulations of continuous-time Markov chains.

Science.gov (United States)

Serebrinsky, Santiago A

2011-03-01

We rigorously establish a physical time scale for a general class of kinetic Monte Carlo algorithms for the simulation of continuous-time Markov chains. This class of algorithms encompasses rejection-free (or BKL) and rejection (or "standard") algorithms. For rejection algorithms, it was formerly considered that the availability of a physical time scale (instead of Monte Carlo steps) was empirical, at best. Use of Monte Carlo steps as a time unit now becomes completely unnecessary.

Role of Melatonin in Cell-Wall Disassembly and Chilling Tolerance in Cold-Stored Peach Fruit.

Science.gov (United States)

Cao, Shifeng; Bian, Kun; Shi, Liyu; Chung, Hsiao-Hang; Chen, Wei; Yang, Zhenfeng

2018-06-06

Melatonin reportedly increases chilling tolerance in postharvest peach fruit during cold storage, but information on its effects on cell-wall disassembly in chilling-injured peaches is limited. In this study, we investigated the role of cell-wall depolymerization in chilling-tolerance induction in melatonin-treated peaches. Treatment with 100 μM melatonin alleviated chilling symptoms (mealiness) characterized by a decrease in fruit firmness and increase in juice extractability in treated peaches during storage. The loss of neutral sugars, such as arabinose and galactose, in both the 1,2-cyclohexylenedinitrilotetraacetic acid (CDTA)- and Na 2 CO 3 -soluble fractions was observed at 7 days in treated peaches, but the contents increased after 28 days of storage. Atomic-force-microscopy (AFM) analysis revealed that the polysaccharide widths in the CDTA- and Na 2 CO 3 -soluble fractions in the treated fruit were mainly distributed in a shorter range, as compared with those in the control fruit. In addition, the expression profiles of a series of cell-wall-related genes showed that melatonin treatment maintained the balance between transcripts of PpPME and PpPG, which accompany the up-regulation of several other genes involved in cell-wall disassembly. Taken together, our results suggested that the reduced mealiness by melatonin was probably associated with its positive regulation of numerous cell-wall-modifying enzymes and proteins; thus, the depolymerization of the cell-wall polysaccharides in the peaches treated with melatonin was maintained, and the treated fruit could soften gradually during cold storage.

Characterization of spent fuel disassembly hardware and nonfuel bearing components and their relationship to 10 CFR 61

International Nuclear Information System (INIS)

Luksic, A.T.

1987-02-01

There are a variety of wastes that will be disposed of by the federal waste management system under the Nuclear Waste Policy Act of 1982. The primary waste form is spent nuclear fuel. Currently, this is in the form of fuel assemblies. If the fuel pins are removed from the fuel assembly, as in consolidation, then the fuel pins and the structural portion of the fuel assembly must be considered as separate waste streams. The structural hardware consists of end fittings, grid spacers, water rods (BWR 8 x 8 only), control rod guide tubes (PWR only) and various nuts, washers, springs, etc. These are referred to as spent fuel disassembly (SFD) hardware. There will also be a number of other components which are defined in Appendix E of 10 CFR 961, the standard utility contract. These are referred to as nonfuel-bearing (NFB) components, and include fuel channels (BWR), control rods, fission chambers, neutron sources, thimble plugs, and other components. This paper characterizes spent fuel disassembly (SFD) hardware, and nonfuel-bearing (NFB) components for the most abundant fuel types. The descriptions and figures given are representative for the items described. Many subvariants exist due to design evaluation, which are not covered. This paper also discusses the relationship of these wastes to 10 CFR 61 waste classification

Scaling properties in time-varying networks with memory

Science.gov (United States)

Kim, Hyewon; Ha, Meesoon; Jeong, Hawoong

2015-12-01

The formation of network structure is mainly influenced by an individual node's activity and its memory, where activity can usually be interpreted as the individual inherent property and memory can be represented by the interaction strength between nodes. In our study, we define the activity through the appearance pattern in the time-aggregated network representation, and quantify the memory through the contact pattern of empirical temporal networks. To address the role of activity and memory in epidemics on time-varying networks, we propose temporal-pattern coarsening of activity-driven growing networks with memory. In particular, we focus on the relation between time-scale coarsening and spreading dynamics in the context of dynamic scaling and finite-size scaling. Finally, we discuss the universality issue of spreading dynamics on time-varying networks for various memory-causality tests.

Bounds of Certain Dynamic Inequalities on Time Scales

Directory of Open Access Journals (Sweden)

Deepak B. Pachpatte

2014-10-01

Full Text Available In this paper we study explicit bounds of certain dynamic integral inequalities on time scales. These estimates give the bounds on unknown functions which can be used in studying the qualitative aspects of certain dynamic equations. Using these inequalities we prove the uniqueness of some partial integro-differential equations on time scales.

The pedagogical value of Disassemble/Analyze/Assemble (DAA) activities: Assessing the potential for motivation and transfer

Science.gov (United States)

Dalrymple, Odesma Onika

Undergraduate engineering institutions are currently seeking to improve recruiting practices and to retain engineering majors particularly by addressing what many studies document as a major challenge of poor instruction. There is an undisputed need for instructional practices that motivate students in addition to facilitating the transfer of learning beyond the classroom. Reverse engineering and product dissection, more broadly termed Disassemble/Analyze/Assemble (DAA) activities, have shown potential to address these concerns, based on the reviews of students and professors alike. DAA activities involve the systematic deconstruction of an artifact, the subsequent analysis and possible reconstruction of its components for the purpose of understanding the embodied fundamental concepts, design principles and developmental processes. These activities have been part of regular industry practice for some time; however, the systematic analysis of their benefits for learning and instruction is a relatively recent phenomenon. A number of studies have provided highly descriptive accounts of curricula and possible outcomes of DAA activities; but, relatively few have compared participants doing DAA activities to a control group doing more traditional activities. In this respect, two quasi-experiments were conducted as part of a first-year engineering laboratory, and it was hypothesized that students who engaged in the DAA activity would be more motivated and would demonstrate higher frequencies of transfer than the control. A DAA activity that required students to disassemble a single-use camera and analyze its components to discover how it works was compared to a step-by-step laboratory activity in the first experiment and a lecture method of instruction in the second experiment. In both experiments, over forty percent of the students that engaged in the DAA activity demonstrated the ability to transfer the knowledge gained about the functions of the camera's components and

Real-time simulation of large-scale floods

Science.gov (United States)

Liu, Q.; Qin, Y.; Li, G. D.; Liu, Z.; Cheng, D. J.; Zhao, Y. H.

2016-08-01

According to the complex real-time water situation, the real-time simulation of large-scale floods is very important for flood prevention practice. Model robustness and running efficiency are two critical factors in successful real-time flood simulation. This paper proposed a robust, two-dimensional, shallow water model based on the unstructured Godunov- type finite volume method. A robust wet/dry front method is used to enhance the numerical stability. An adaptive method is proposed to improve the running efficiency. The proposed model is used for large-scale flood simulation on real topography. Results compared to those of MIKE21 show the strong performance of the proposed model.

Time-dependent scaling patterns in high frequency financial data

Science.gov (United States)

Nava, Noemi; Di Matteo, Tiziana; Aste, Tomaso

2016-10-01

We measure the influence of different time-scales on the intraday dynamics of financial markets. This is obtained by decomposing financial time series into simple oscillations associated with distinct time-scales. We propose two new time-varying measures of complexity: 1) an amplitude scaling exponent and 2) an entropy-like measure. We apply these measures to intraday, 30-second sampled prices of various stock market indices. Our results reveal intraday trends where different time-horizons contribute with variable relative amplitudes over the course of the trading day. Our findings indicate that the time series we analysed have a non-stationary multifractal nature with predominantly persistent behaviour at the middle of the trading session and anti-persistent behaviour at the opening and at the closing of the session. We demonstrate that these patterns are statistically significant, robust, reproducible and characteristic of each stock market. We argue that any modelling, analytics or trading strategy must take into account these non-stationary intraday scaling patterns.

Nonlinear triple-point problems on time scales

Directory of Open Access Journals (Sweden)

Douglas R. Anderson

2004-04-01

Full Text Available We establish the existence of multiple positive solutions to the nonlinear second-order triple-point boundary-value problem on time scales, $$displaylines{ u^{Delta abla}(t+h(tf(t,u(t=0, cr u(a=alpha u(b+delta u^Delta(a,quad eta u(c+gamma u^Delta(c=0 }$$ for $tin[a,c]subsetmathbb{T}$, where $mathbb{T}$ is a time scale, $eta, gamma, deltage 0$ with $Beta+gamma>0$, $0

Hydrodynamic time scales for intense laser-heated clusters

International Nuclear Information System (INIS)

Parra, Enrique; Alexeev, Ilya; Fan, Jingyun; Kim, Kiong Y.; McNaught, Stuart J.; Milchberg, Howard M.

2003-01-01

Measurements are presented of x-ray (>1.5 keV) and extreme ultraviolet (EUV, λ equal to 2-44 nm) emission from argon clusters irradiated with constant-energy (50 mJ), variable-width laser pulses ranging from 100 fs to 10 ns. The results for clusters can be understood in terms of two time scales: a short time scale for optimal resonant absorption at the critical-density layer in the expanding plasma, and a longer time scale for the plasma to drop below critical density. We present a one-dimensional hydrodynamic model of the intense laser-cluster interaction in which the laser field is treated self-consistently. We find that nonuniform expansion of the heated material results in long-time resonance of the laser field at the critical-density plasma layer. These simulations explain the dependence of generation efficiency on laser pulse width

Physics in space-time with scale-dependent metrics

Science.gov (United States)

Balankin, Alexander S.

2013-10-01

We construct three-dimensional space Rγ3 with the scale-dependent metric and the corresponding Minkowski space-time Mγ,β4 with the scale-dependent fractal (DH) and spectral (DS) dimensions. The local derivatives based on scale-dependent metrics are defined and differential vector calculus in Rγ3 is developed. We state that Mγ,β4 provides a unified phenomenological framework for dimensional flow observed in quite different models of quantum gravity. Nevertheless, the main attention is focused on the special case of flat space-time M1/3,14 with the scale-dependent Cantor-dust-like distribution of admissible states, such that DH increases from DH=2 on the scale ≪ℓ0 to DH=4 in the infrared limit ≫ℓ0, where ℓ0 is the characteristic length (e.g. the Planck length, or characteristic size of multi-fractal features in heterogeneous medium), whereas DS≡4 in all scales. Possible applications of approach based on the scale-dependent metric to systems of different nature are briefly discussed.

Time scales of supercooled water and implications for reversible polyamorphism

Science.gov (United States)

Limmer, David T.; Chandler, David

2015-09-01

Deeply supercooled water exhibits complex dynamics with large density fluctuations, ice coarsening and characteristic time scales extending from picoseconds to milliseconds. Here, we discuss implications of these time scales as they pertain to two-phase coexistence and to molecular simulations of supercooled water. Specifically, we argue that it is possible to discount liquid-liquid criticality because the time scales imply that correlation lengths for such behaviour would be bounded by no more than a few nanometres. Similarly, it is possible to discount two-liquid coexistence because the time scales imply a bounded interfacial free energy that cannot grow in proportion to a macroscopic surface area. From time scales alone, therefore, we see that coexisting domains of differing density in supercooled water can be no more than nanoscale transient fluctuations.

Steffensen's Integral Inequality on Time Scales

Directory of Open Access Journals (Sweden)

Ozkan Umut Mutlu

2007-01-01

Full Text Available We establish generalizations of Steffensen's integral inequality on time scales via the diamond- dynamic integral, which is defined as a linear combination of the delta and nabla integrals.

Time scales of tunneling decay of a localized state

International Nuclear Information System (INIS)

Ban, Yue; Muga, J. G.; Sherman, E. Ya.; Buettiker, M.

2010-01-01

Motivated by recent time-domain experiments on ultrafast atom ionization, we analyze the transients and time scales that characterize, aside from the relatively long lifetime, the decay of a localized state by tunneling. While the tunneling starts immediately, some time is required for the outgoing flux to develop. This short-term behavior depends strongly on the initial state. For the initial state, tightly localized so that the initial transients are dominated by over-the-barrier motion, the time scale for flux propagation through the barrier is close to the Buettiker-Landauer traversal time. Then a quasistationary, slow-decay process follows, which sets ideal conditions for observing diffraction in time at longer times and distances. To define operationally a tunneling time at the barrier edge, we extrapolate backward the propagation of the wave packet that escaped from the potential. This extrapolated time is considerably longer than the time scale of the flux and density buildup at the barrier edge.

Finite-Time Stability of Large-Scale Systems with Interval Time-Varying Delay in Interconnection

Directory of Open Access Journals (Sweden)

T. La-inchua

2017-01-01

Full Text Available We investigate finite-time stability of a class of nonlinear large-scale systems with interval time-varying delays in interconnection. Time-delay functions are continuous but not necessarily differentiable. Based on Lyapunov stability theory and new integral bounding technique, finite-time stability of large-scale systems with interval time-varying delays in interconnection is derived. The finite-time stability criteria are delays-dependent and are given in terms of linear matrix inequalities which can be solved by various available algorithms. Numerical examples are given to illustrate effectiveness of the proposed method.

Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion

DEFF Research Database (Denmark)

Liu, Linna; Li, Jing; Zhang, Liwang

2015-01-01

Cytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal reorganization through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. Rac1 was knocked out in mouse keratinocytes and it was found...... that actin filaments disassembled. In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1). These effects were independent of the signaling pathways for p21-activated kinase....../LIM kinase (Pak/LIMK), protein kinase C, or protein kinase D or generation of reactive oxygen species. Similarly, when actin polymerization was specifically inhibited or Rac1 was knocked down, cofilin phosphorylation was enhanced and SSH1 was repressed. Repression of SSH1 partially blocked actin...

Assembly/disassembly of a complex icosahedral virus to incorporate heterologous nucleic acids

Science.gov (United States)

Pascual, Elena; Mata, Carlos P.; Carrascosa, José L.; Castón, José R.

2017-12-01

Hollow protein containers are widespread in nature, and include virus capsids as well as eukaryotic and bacterial complexes. Protein cages are studied extensively for applications in nanotechnology, nanomedicine and materials science. Their inner and outer surfaces can be modified chemically or genetically, and the internal cavity can be used to template, store and/or arrange molecular cargos. Virus capsids and virus-like particles (VLP, noninfectious particles) provide versatile platforms for nanoscale bioengineering. Study of capsid protein self-assembly into monodispersed particles, and of VLP structure and biophysics is necessary not only to understand natural processes, but also to infer how these platforms can be redesigned to furnish novel functional VLP. Here we address the assembly dynamics of infectious bursal disease virus (IBDV), a complex icosahedral virus. IBDV has a ~70 nm-diameter T  =  13 capsid with VP2 trimers as the only structural subunits. During capsid assembly, VP2 is synthesized as a precursor (pVP2) whose C terminus is cleaved. The pVP2 C terminus has an amphipathic helix that controls VP2 polymorphism. In the absence of the VP3 scaffolding protein, necessary for control of assembly, 466/456-residue pVP2 intermediates bearing this helix assemble into VLP only when expressed with an N-terminal His6 tag (the HT-VP2-466 protein). HT-VP2-466 capsids are optimal for genetic insertion of proteins (cargo space ~78 000 nm3). We established an in vitro assembly/disassembly system of HT-VP2-466-based VLP for heterologous nucleic acid packaging and/or encapsulation of drugs and other molecules. HT-VP2-466 (empty) capsids were disassembled and reassembled by dialysis against low-salt/basic pH and high-salt/acid pH buffers, respectively, thus illustrating the reversibility in vitro of IBDV capsid assembly. HT-VP2-466 VLP also packed heterologous DNA by non-specific confinement during assembly. These and previous results establish the bases

Scale-invariant Green-Kubo relation for time-averaged diffusivity

Science.gov (United States)

Meyer, Philipp; Barkai, Eli; Kantz, Holger

2017-12-01

In recent years it was shown both theoretically and experimentally that in certain systems exhibiting anomalous diffusion the time- and ensemble-averaged mean-squared displacement are remarkably different. The ensemble-averaged diffusivity is obtained from a scaling Green-Kubo relation, which connects the scale-invariant nonstationary velocity correlation function with the transport coefficient. Here we obtain the relation between time-averaged diffusivity, usually recorded in single-particle tracking experiments, and the underlying scale-invariant velocity correlation function. The time-averaged mean-squared displacement is given by 〈δ2¯〉 ˜2 DνtβΔν -β , where t is the total measurement time and Δ is the lag time. Here ν is the anomalous diffusion exponent obtained from ensemble-averaged measurements 〈x2〉 ˜tν , while β ≥-1 marks the growth or decline of the kinetic energy 〈v2〉 ˜tβ . Thus, we establish a connection between exponents that can be read off the asymptotic properties of the velocity correlation function and similarly for the transport constant Dν. We demonstrate our results with nonstationary scale-invariant stochastic and deterministic models, thereby highlighting that systems with equivalent behavior in the ensemble average can differ strongly in their time average. If the averaged kinetic energy is finite, β =0 , the time scaling of 〈δ2¯〉 and 〈x2〉 are identical; however, the time-averaged transport coefficient Dν is not identical to the corresponding ensemble-averaged diffusion constant.

Cross-Scale Modelling of Subduction from Minute to Million of Years Time Scale

Science.gov (United States)

Sobolev, S. V.; Muldashev, I. A.

2015-12-01

Subduction is an essentially multi-scale process with time-scales spanning from geological to earthquake scale with the seismic cycle in-between. Modelling of such process constitutes one of the largest challenges in geodynamic modelling today.Here we present a cross-scale thermomechanical model capable of simulating the entire subduction process from rupture (1 min) to geological time (millions of years) that employs elasticity, mineral-physics-constrained non-linear transient viscous rheology and rate-and-state friction plasticity. The model generates spontaneous earthquake sequences. The adaptive time-step algorithm recognizes moment of instability and drops the integration time step to its minimum value of 40 sec during the earthquake. The time step is then gradually increased to its maximal value of 5 yr, following decreasing displacement rates during the postseismic relaxation. Efficient implementation of numerical techniques allows long-term simulations with total time of millions of years. This technique allows to follow in details deformation process during the entire seismic cycle and multiple seismic cycles. We observe various deformation patterns during modelled seismic cycle that are consistent with surface GPS observations and demonstrate that, contrary to the conventional ideas, the postseismic deformation may be controlled by viscoelastic relaxation in the mantle wedge, starting within only a few hours after the great (M>9) earthquakes. Interestingly, in our model an average slip velocity at the fault closely follows hyperbolic decay law. In natural observations, such deformation is interpreted as an afterslip, while in our model it is caused by the viscoelastic relaxation of mantle wedge with viscosity strongly varying with time. We demonstrate that our results are consistent with the postseismic surface displacement after the Great Tohoku Earthquake for the day-to-year time range. We will also present results of the modeling of deformation of the

Sodium removal disassembly and examination of the Fermi secondary sodium pump

International Nuclear Information System (INIS)

Maffei, H.P.; Funk, C.W.; Ballif, J.L.

1974-01-01

The Fermi secondary pump is a centrifugal single stage design. The pump had been operated more than 42,000 hours between 450 and 800 0 F. Sodium was drained from the pump in 1973 and the system was back filled with carbon dioxide. The pump was fabricated for 2.25 Cr-1 Mo Croloy steel. Prior to cleaning the pump was inerted and heated with 150 0 F nitrogen using the pump casing as the containment vessel. The water-vapor-nitrogen process was used in three increasing stages of water concentration. The hydrogen concentration in the discharge line was followed as an indicator of the sodium-water reaction rate. Upon completion of the hydrogen evolution, the pump was rinsed several times with hot water. Six pounds of sodium were removed from the pump during a process cycle of 79 hours including rinsing. The maximum pump temperature recorded was 175 0 F with no variation exceeding 10 0 F. The hydrogen concentration in the effluent provided a very satisfactory index for control of the reaction by adjustment of the water-vapor concentration feed to the system. Rinsing effectiveness was limited by a pool of water in the volute that was not drainable with the available system hook up. Sodium and its compounds were removed from all internal surfaces that could be observed by the first stage of disassembly. All such surfaces were coated with a black deposit. Areas above the sodium liquid level were coated with a vermillion colored oxide. Sodium was found on the (1) threads of the impeller nut lock screw, (2) impeller nut-tapered shaft interface, and (3) vapor deposited sodium was found in the oil seal

Temperature dependence of fluctuation time scales in spin glasses

DEFF Research Database (Denmark)

Kenning, Gregory G.; Bowen, J.; Sibani, Paolo

2010-01-01

Using a series of fast cooling protocols we have probed aging effects in the spin glass state as a function of temperature. Analyzing the logarithmic decay found at very long time scales within a simple phenomenological barrier model, leads to the extraction of the fluctuation time scale of the s...

Development of an advanced, continuous mild-gasification process for the production of coproducts. Report for Task 4.8, Decontamination and disassembly of the mild-gasification and char-to-carbon PRUs and disposal of products from testing

Energy Technology Data Exchange (ETDEWEB)

Merriam, N.W. [Western Research Inst., Laramie, WY (United States); Jha, Mahesh C. [AMAX Research and Development Center, Golden, CO (United States)

1991-11-01

This report contains descriptions of mild-gasification and char-to-carbon process research units (PRUS) used by WRI and AMAX R&D Center to conduct tests under contract AC21-87MC24268. Descriptions of materials produced during those tests are also contained herein. Western Research Institute proposes to dispose of remaining fines and dried coal by combustion and remaining coal liquids by incineration during mid-1992. The mild-gasification PRU will be used for additional tests until 1993, at which time WRI proposes to decontaminate and disassemble the PRU. AMAX R&D Center intends to return the spent char, any remaining feed char, and unusable product carbon to the Eagle Butte Mine near Gillette, Wyoming, from where the coal originally came. The solid products will be added to the mine`s coal product stream. Coal liquids collected from condensers will be concentrated and sent to a local oil and solvent recycling company where the liquids will be burned as fuel. The char-to-carbon PRU will be operated periodically until 1993 when the plant will be decontaminated and disassembled.

uncertain dynamic systems on time scales

Directory of Open Access Journals (Sweden)

V. Lakshmikantham

1995-01-01

Full Text Available A basic feedback control problem is that of obtaining some desired stability property from a system which contains uncertainties due to unknown inputs into the system. Despite such imperfect knowledge in the selected mathematical model, we often seek to devise controllers that will steer the system in a certain required fashion. Various classes of controllers whose design is based on the method of Lyapunov are known for both discrete [4], [10], [15], and continuous [3–9], [11] models described by difference and differential equations, respectively. Recently, a theory for what is known as dynamic systems on time scales has been built which incorporates both continuous and discrete times, namely, time as an arbitrary closed sets of reals, and allows us to handle both systems simultaneously [1], [2], [12], [13]. This theory permits one to get some insight into and better understanding of the subtle differences between discrete and continuous systems. We shall, in this paper, utilize the framework of the theory of dynamic systems on time scales to investigate the stability properties of conditionally invariant sets which are then applied to discuss controlled systems with uncertain elements. For the notion of conditionally invariant set and its stability properties, see [14]. Our results offer a new approach to the problem in question.

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.

Science.gov (United States)

Belluzzi, Elisa; Gonnelli, Adriano; Cirnaru, Maria-Daniela; Marte, Antonella; Plotegher, Nicoletta; Russo, Isabella; Civiero, Laura; Cogo, Susanna; Carrion, Maria Perèz; Franchin, Cinzia; Arrigoni, Giorgio; Beltramini, Mariano; Bubacco, Luigi; Onofri, Franco; Piccoli, Giovanni; Greggio, Elisa

2016-01-13

Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic proteins. Here, we show that LRRK2 kinase activity influences the dynamics of synaptic vesicle fusion. We therefore investigated whether LRRK2 phosphorylates component(s) of the exo/endocytosis machinery. We have previously observed that LRRK2 interacts with NSF, a hexameric AAA+ ATPase that couples ATP hydrolysis to the disassembling of SNARE proteins allowing them to enter another fusion cycle during synaptic exocytosis. Here, we demonstrate that NSF is a substrate of LRRK2 kinase activity. LRRK2 phosphorylates full-length NSF at threonine 645 in the ATP binding pocket of D2 domain. Functionally, NSF phosphorylated by LRRK2 displays enhanced ATPase activity and increased rate of SNARE complex disassembling. Substitution of threonine 645 with alanine abrogates LRRK2-mediated increased ATPase activity. Given that the most common Parkinson's disease LRRK2 G2019S mutation displays increased kinase activity, our results suggest that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of NSF.

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

Science.gov (United States)

Uchil, Pradeep D.; Pawliczek, Tobias; Reynolds, Tracy D.; Ding, Siyuan; Hinz, Angelika; Munro, James B.; Huang, Fang; Floyd, Robert W.; Yang, Haitao; Hamilton, William L.; Bewersdorf, Joerg; Xiong, Yong; Calderwood, David A.; Mothes, Walther

2014-01-01

ABSTRACT Focal adhesions are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of focal adhesions is crucial for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating focal adhesion dynamics. Here, we identify TRIM15, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal adhesions. TRIM15 localizes to focal contacts in a myosin-II-independent manner by an interaction between its coiled-coil domain and the LD2 motif of paxillin. Unlike other focal adhesion proteins, TRIM15 is a stable focal adhesion component with restricted mobility due to its ability to form oligomers. TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates, in addition to enlarged focal adhesions. Thus, our studies demonstrate a cellular function for TRIM15 as a regulatory component of focal adhesion turnover and cell migration. PMID:25015296

Evaluation of scaling invariance embedded in short time series.

Directory of Open Access Journals (Sweden)

Xue Pan

Full Text Available Scaling invariance of time series has been making great contributions in diverse research fields. But how to evaluate scaling exponent from a real-world series is still an open problem. Finite length of time series may induce unacceptable fluctuation and bias to statistical quantities and consequent invalidation of currently used standard methods. In this paper a new concept called correlation-dependent balanced estimation of diffusion entropy is developed to evaluate scale-invariance in very short time series with length ~10(2. Calculations with specified Hurst exponent values of 0.2,0.3,...,0.9 show that by using the standard central moving average de-trending procedure this method can evaluate the scaling exponents for short time series with ignorable bias (≤0.03 and sharp confidential interval (standard deviation ≤0.05. Considering the stride series from ten volunteers along an approximate oval path of a specified length, we observe that though the averages and deviations of scaling exponents are close, their evolutionary behaviors display rich patterns. It has potential use in analyzing physiological signals, detecting early warning signals, and so on. As an emphasis, the our core contribution is that by means of the proposed method one can estimate precisely shannon entropy from limited records.

Evaluation of scaling invariance embedded in short time series.

Science.gov (United States)

Pan, Xue; Hou, Lei; Stephen, Mutua; Yang, Huijie; Zhu, Chenping

2014-01-01

Scaling invariance of time series has been making great contributions in diverse research fields. But how to evaluate scaling exponent from a real-world series is still an open problem. Finite length of time series may induce unacceptable fluctuation and bias to statistical quantities and consequent invalidation of currently used standard methods. In this paper a new concept called correlation-dependent balanced estimation of diffusion entropy is developed to evaluate scale-invariance in very short time series with length ~10(2). Calculations with specified Hurst exponent values of 0.2,0.3,...,0.9 show that by using the standard central moving average de-trending procedure this method can evaluate the scaling exponents for short time series with ignorable bias (≤0.03) and sharp confidential interval (standard deviation ≤0.05). Considering the stride series from ten volunteers along an approximate oval path of a specified length, we observe that though the averages and deviations of scaling exponents are close, their evolutionary behaviors display rich patterns. It has potential use in analyzing physiological signals, detecting early warning signals, and so on. As an emphasis, the our core contribution is that by means of the proposed method one can estimate precisely shannon entropy from limited records.

Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit.

Directory of Open Access Journals (Sweden)

Cheen Fei Chin

2016-07-01

Full Text Available Cytokinesis requires the spatio-temporal coordination of membrane deposition and primary septum (PS formation at the division site to drive acto-myosin ring (AMR constriction. It has been demonstrated that AMR constriction invariably occurs only after the mitotic spindle disassembly. It has also been established that Chitin Synthase II (Chs2p neck localization precedes mitotic spindle disassembly during mitotic exit. As AMR constriction depends upon PS formation, the question arises as to how chitin deposition is regulated so as to prevent premature AMR constriction and mitotic spindle breakage. In this study, we propose that cells regulate the coordination between spindle disassembly and AMR constriction via timely endocytosis of cytokinetic enzymes, Chs2p, Chs3p, and Fks1p. Inhibition of endocytosis leads to over accumulation of cytokinetic enzymes during mitotic exit, which accelerates the constriction of the AMR, and causes spindle breakage that eventually could contribute to monopolar spindle formation in the subsequent round of cell division. Intriguingly, the mitotic spindle breakage observed in endocytosis mutants can be rescued either by deleting or inhibiting the activities of, CHS2, CHS3 and FKS1, which are involved in septum formation. The findings from our study highlight the importance of timely endocytosis of cytokinetic enzymes at the division site in safeguarding mitotic spindle integrity during mitotic exit.

Super-transient scaling in time-delay autonomous Boolean network motifs

Energy Technology Data Exchange (ETDEWEB)

D' Huys, Otti, E-mail: otti.dhuys@phy.duke.edu; Haynes, Nicholas D. [Department of Physics, Duke University, Durham, North Carolina 27708 (United States); Lohmann, Johannes [Department of Physics, Duke University, Durham, North Carolina 27708 (United States); Institut für Theoretische Physik, Technische Universität Berlin, Hardenbergstraße 36, 10623 Berlin (Germany); Gauthier, Daniel J. [Department of Physics, Duke University, Durham, North Carolina 27708 (United States); Department of Physics, The Ohio State University, Columbus, Ohio 43210 (United States)

2016-09-15

Autonomous Boolean networks are commonly used to model the dynamics of gene regulatory networks and allow for the prediction of stable dynamical attractors. However, most models do not account for time delays along the network links and noise, which are crucial features of real biological systems. Concentrating on two paradigmatic motifs, the toggle switch and the repressilator, we develop an experimental testbed that explicitly includes both inter-node time delays and noise using digital logic elements on field-programmable gate arrays. We observe transients that last millions to billions of characteristic time scales and scale exponentially with the amount of time delays between nodes, a phenomenon known as super-transient scaling. We develop a hybrid model that includes time delays along network links and allows for stochastic variation in the delays. Using this model, we explain the observed super-transient scaling of both motifs and recreate the experimentally measured transient distributions.

AGR-3/4 Irradiation Test Train Disassembly and Component Metrology First Look Report

Energy Technology Data Exchange (ETDEWEB)

Stempien, John Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Francine Joyce [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip Lon [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-09-01

The AGR-3/4 experiment was designed to study fission product transport within graphitic matrix material and nuclear-grade graphite. To this end, this experiment consisted of 12 capsules, each fueled with 4 compacts containing UCO TRISO particles as driver fuel and 20 UCO designed-to-fail (DTF) fuel particles in each compact. The DTF fuel was fabricated with a thin pyrocarbon layer which was intended to fail during irradiation and provide a source of fission products. These fission products could then migrate through the compact and into the surrounding concentric rings of graphitic matrix material and/or nuclear graphite. Through post-irradiation examination (PIE) of the rings (including physical sampling and gamma scanning) fission product concentration profiles within the rings can be determined. These data can be used to elucidate fission product transport parameters (e.g. diffusion coefficients within the test materials) which will be used to inform and refine models of fission product transport. After irradiation in the Advanced Test Reactor (ATR) had been completed in April 2014, the AGR-3/4 experiment was shipped to the Hot Fuel Examination Facility (HFEF) at the Materials and Fuels Complex (MFC) for inspection, disassembly, and metrology. The AGR-3/4 test train was received at MFC in two separate shipments between February and April 2015. Visual examinations of the test train exterior did not indicate dimensional distortion, and only two small discolored areas were observed at the bottom of Capsules 8 and 9. No corresponding discoloration was found on the inside of these capsules, however. Prior to disassembly, the two test train sections were subject to analysis via the Precision Gamma Scanner (PGS), which did not indicate that any gross fuel relocation had occurred. A series of specialized tools (including clamps, cutters, and drills) had been designed and fabricated in order to carry out test train disassembly and recovery of capsule components (graphite

AGR-3/4 Irradiation Test Train Disassembly and Component Metrology First Look Report

Energy Technology Data Exchange (ETDEWEB)

Stempien, John Dennis [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Francine Joyce [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip Lon [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-03-01

The AGR-3/4 experiment was designed to study fission product transport within graphitic matrix material and nuclear-grade graphite. To this end, this experiment consisted of 12 capsules, each fueled with 4 compacts containing UCO TRISO particles as driver fuel and 20 UCO designed-to-fail (DTF) fuel particles in each compact. The DTF fuel was fabricated with a thin pyrocarbon layer which was intended to fail during irradiation and provide a source of fission products. These fission products could then migrate through the compact and into the surrounding concentric rings of graphitic matrix material and/or nuclear graphite. Through post-irradiation examination (PIE) of the rings (including physical sampling and gamma scanning) fission product concentration profiles within the rings can be determined. These data can be used to elucidate fission product transport parameters (e.g. diffusion coefficients within the test materials) which will be used to inform and refine models of fission product transport. After irradiation in the Advanced Test Reactor (ATR) had been completed in April 2014, the AGR-3/4 experiment was shipped to the Hot Fuel Examination Facility (HFEF) at the Materials and Fuels Complex (MFC) for inspection, disassembly, and metrology. The AGR-3/4 test train was received at MFC in two separate shipments between February and April 2015. Visual examinations of the test train exterior did not indicate dimensional distortion, and only two small discolored areas were observed at the bottom of Capsules 8 and 9. No corresponding discoloration was found on the inside of these capsules, however. Prior to disassembly, the two test train sections were subject to analysis via the Precision Gamma Scanner (PGS), which did not indicate that any gross fuel relocation had occurred. A series of specialized tools (including clamps, cutters, and drills) had been designed and fabricated in order to carry out test train disassembly and recovery of capsule components (graphite

Dynamics symmetries of Hamiltonian system on time scales

Energy Technology Data Exchange (ETDEWEB)

Peng, Keke, E-mail: pengkeke88@126.com; Luo, Yiping, E-mail: zjstulyp@126.com [Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018 (China)

2014-04-15

In this paper, the dynamics symmetries of Hamiltonian system on time scales are studied. We study the symmetries and quantities based on the calculation of variation and Lie transformation group. Particular focus lies in: the Noether symmetry leads to the Noether conserved quantity and the Lie symmetry leads to the Noether conserved quantity if the infinitesimal transformations satisfy the structure equation. As the new application of result, at end of the article, we give a simple example of Noether symmetry and Lie symmetry on time scales.

A Novel Multiple-Time Scale Integrator for the Hybrid Monte Carlo Algorithm

International Nuclear Information System (INIS)

Kamleh, Waseem

2011-01-01

Hybrid Monte Carlo simulations that implement the fermion action using multiple terms are commonly used. By the nature of their formulation they involve multiple integration time scales in the evolution of the system through simulation time. These different scales are usually dealt with by the Sexton-Weingarten nested leapfrog integrator. In this scheme the choice of time scales is somewhat restricted as each time step must be an exact multiple of the next smallest scale in the sequence. A novel generalisation of the nested leapfrog integrator is introduced which allows for far greater flexibility in the choice of time scales, as each scale now must only be an exact multiple of the smallest step size.

Microsecond time-scale kinetics of transient biochemical reactions

NARCIS (Netherlands)

Mitic, S.; Strampraad, M.J.F.; Hagen, W.R.; de Vries, S.

2017-01-01

To afford mechanistic studies in enzyme kinetics and protein folding in the microsecond time domain we have developed a continuous-flow microsecond time-scale mixing instrument with an unprecedented dead-time of 3.8 ± 0.3 μs. The instrument employs a micro-mixer with a mixing time of 2.7 μs

Full-scale and time-scale heating experiments at Stripa: preliminary results. Technical project report No. 11

International Nuclear Information System (INIS)

Cook, N.G.W.; Hood, M.

1978-12-01

Two full-scale heating experiments and a time-scale heating experiment have recently been started in granite 340 meters below surface. The purpose of the full-scale heating experiments is to assess the near-field effects of thermal loading for the design of an underground repository of nuclear wastes. That of the time-scale heating experiments is to obtain field data of the interaction between heaters and its effect on the rock mass during a period of about two years, which corresponds to about twenty years of full-scale operation. Geological features of the rock around each experiment have been mapped carefully, and temperatures, stresses and displacements induced in the rock by heating have been calculated in advance of the experiments. Some 800 different measurements are recorded at frequent intervals by a computer system situated underground. These data can be compared at any time with predictions made earlier on video display units underground

Length and time scales of atmospheric moisture recycling

Directory of Open Access Journals (Sweden)

R. J. van der Ent

2011-03-01

Full Text Available It is difficult to quantify the degree to which terrestrial evaporation supports the occurrence of precipitation within a certain study region (i.e. regional moisture recycling due to the scale- and shape-dependence of regional moisture recycling ratios. In this paper we present a novel approach to quantify the spatial and temporal scale of moisture recycling, independent of the size and shape of the region under study. In contrast to previous studies, which essentially used curve fitting, the scaling laws presented by us follow directly from the process equation. thus allowing a fair comparison between regions and seasons. The calculation is based on ERA-Interim reanalysis data for the period 1999 to 2008. It is shown that in the tropics or in mountainous terrain the length scale of recycling can be as low as 500 to 2000 km. In temperate climates the length scale is typically between 3000 to 5000 km whereas it amounts to more than 7000 km in desert areas. The time scale of recycling ranges from 3 to 20 days, with the exception of deserts, where it is much longer. The most distinct seasonal differences can be observed over the Northern Hemisphere: in winter, moisture recycling is insignificant, whereas in summer it plays a major role in the climate. The length and time scales of atmospheric moisture recycling can be useful metrics to quantify local climatic effects of land use change.

Neuroprotective Effects against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton

Directory of Open Access Journals (Sweden)

Ann D. Liebert

2016-01-01

Full Text Available Postoperative cognitive dysfunction (POCD is a decline in memory following anaesthesia and surgery in elderly patients. While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheimer's disease. Anesthetics have been implicated in POCD, as has neuroinflammation, as indicated by cytokine inflammatory markers. Photobiomodulation (PBM is an effective treatment for a number of conditions, including inflammation. PBM also has a direct effect on microtubule disassembly in neurons with the formation of small, reversible varicosities, which cause neural blockade and alleviation of pain symptoms. This mimics endogenously formed varicosities that are neuroprotective against damage, toxins, and the formation of larger, destructive varicosities and focal swellings. It is proposed that PBM may be effective as a preconditioning treatment against POCD; similar to the PBM treatment, protective and abscopal effects that have been demonstrated in experimental models of macular degeneration, neurological, and cardiac conditions.

Large Deviations for Two-Time-Scale Diffusions, with Delays

International Nuclear Information System (INIS)

Kushner, Harold J.

2010-01-01

We consider the problem of large deviations for a two-time-scale reflected diffusion process, possibly with delays in the dynamical terms. The Dupuis-Ellis weak convergence approach is used. It is perhaps the most intuitive and simplest for the problems of concern. The results have applications to the problem of approximating optimal controls for two-time-scale systems via use of the averaged equation.

Some New Inequalities of Opial's Type on Time Scales

Directory of Open Access Journals (Sweden)

Samir H. Saker

2012-01-01

Full Text Available We will prove some new dynamic inequalities of Opial's type on time scales. The results not only extend some results in the literature but also improve some of them. Some continuous and discrete inequalities are derived from the main results as special cases. The results can be applied on the study of distribution of generalized zeros of half-linear dynamic equations on time scales.

Qualitative aspects of Volterra integro-dynamic system on time scales

Directory of Open Access Journals (Sweden)

Vasile Lupulescu

2013-01-01

Full Text Available This paper deals with the resolvent, asymptotic stability and boundedness of the solution of time-varying Volterra integro-dynamic system on time scales in which the coefficient matrix is not necessarily stable. We generalize at time scale some known properties about asymptotic behavior and boundedness from the continuous case. Some new results for discrete case are obtained.

Time Scale Analysis of Interest Rate Spreads and Output Using Wavelets

Directory of Open Access Journals (Sweden)

Marco Gallegati

2013-04-01

Full Text Available This paper adds to the literature on the information content of different spreads for real activity by explicitly taking into account the time scale relationship between a variety of monetary and financial indicators (real interest rate, term and credit spreads and output growth. By means of wavelet-based exploratory data analysis we obtain richer results relative to the aggregate analysis by identifying the dominant scales of variation in the data and the scales and location at which structural breaks have occurred. Moreover, using the “double residuals” regression analysis on a scale-by-scale basis, we find that changes in the spread in several markets have different information content for output at different time frames. This is consistent with the idea that allowing for different time scales of variation in the data can provide a fruitful understanding of the complex dynamics of economic relationships between variables with non-stationary or transient components, certainly richer than those obtained using standard time domain methods.

Selective visual scaling of time-scale processes facilitates broadband learning of isometric force frequency tracking.

Science.gov (United States)

King, Adam C; Newell, Karl M

2015-10-01

The experiment investigated the effect of selectively augmenting faster time scales of visual feedback information on the learning and transfer of continuous isometric force tracking tasks to test the generality of the self-organization of 1/f properties of force output. Three experimental groups tracked an irregular target pattern either under a standard fixed gain condition or with selectively enhancement in the visual feedback display of intermediate (4-8 Hz) or high (8-12 Hz) frequency components of the force output. All groups reduced tracking error over practice, with the error lowest in the intermediate scaling condition followed by the high scaling and fixed gain conditions, respectively. Selective visual scaling induced persistent changes across the frequency spectrum, with the strongest effect in the intermediate scaling condition and positive transfer to novel feedback displays. The findings reveal an interdependence of the timescales in the learning and transfer of isometric force output frequency structures consistent with 1/f process models of the time scales of motor output variability.

MgATP hydrolysis destabilizes the interaction between subunit H and yeast V1-ATPase, highlighting H's role in V-ATPase regulation by reversible disassembly.

Science.gov (United States)

Sharma, Stuti; Oot, Rebecca A; Wilkens, Stephan

2018-05-12

Vacuolar H+-ATPases (V-ATPases; V1Vo-ATPases) are rotary motor proton pumps that acidify intracellular compartments and in some tissues, the extracellular space. V-ATPase is regulated by reversible disassembly into autoinhibited V1-ATPase and Vo proton channel sectors. An important player in V-ATPase regulation is subunit H, which binds at the interface of V1 and Vo. H is required for MgATPase activity in holo V-ATPase, but also for stabilizing the MgADP inhibited state in membrane detached V1. However, how H fulfills these two functions is poorly understood. To characterize the H-V1 interaction and its role in reversible disassembly, we determined binding affinities of full length H and its N-terminal domain (HNT) for an isolated heterodimer of subunits E and G (EG), the N-terminal domain of subunit a (aNT), and V1 lacking subunit H (V1ΔH). Using isothermal titration calorimetry (ITC) and biolayer interferometry (BLI), we show that HNT binds EG with moderate affinity, that full length H binds aNT weakly, and that both H and HNT bind V1ΔH with high affinity. We also found that only one molecule of HNT binds V1ΔH with high affinity, suggesting conformational asymmetry of the three EG heterodimers in V1ΔH. Moreover, MgATP hydrolysis-driven conformational changes in V1 destabilized the interaction of H, or HNT, with V1ΔH, suggesting an interplay between MgADP inhibition and subunit H. Our observation that H binding is affected by MgATP hydrolysis in V1 points to H's role in the mechanism of reversible disassembly. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

[Construction of the Time Management Scale and examination of the influence of time management on psychological stress response].

Science.gov (United States)

Imura, Tomoya; Takamura, Masahiro; Okazaki, Yoshihiro; Tokunaga, Satoko

2016-10-01

We developed a scale to measure time management and assessed its reliability and validity. We then used this scale to examine the impact of time management on psychological stress response. In Study 1-1, we developed the scale and assessed its internal consistency and criterion-related validity. Findings from a factor analysis revealed three elements of time management, “time estimation,” “time utilization,” and “taking each moment as it comes.” In Study 1-2, we assessed the scale’s test-retest reliability. In Study 1-3, we assessed the validity of the constructed scale. The results indicate that the time management scale has good reliability and validity. In Study 2, we performed a covariance structural analysis to verify our model that hypothesized that time management influences perceived control of time and psychological stress response, and perceived control of time influences psychological stress response. The results showed that time estimation increases the perceived control of time, which in turn decreases stress response. However, we also found that taking each moment as it comes reduces perceived control of time, which in turn increases stress response.

The Chloroplast Division Protein ARC6 Acts to Inhibit Disassembly of GDP-bound FtsZ2.

Science.gov (United States)

Sung, Min Woo; Shaik, Rahamthulla; TerBush, Allan D; Osteryoung, Katherine W; Vitha, Stanislav; Holzenburg, Andreas

2018-05-16

Chloroplasts host photosynthesis and fulfill other metabolic functions that are essential to plant life. They have to divide by binary fission to maintain their numbers throughout cycles of cell division. Chloroplast division is achieved by a complex ring-shaped division machinery located on both the inner (stromal) and the outer (cytosolic) side of the chloroplast envelope. The inner division ring (termed the Z ring) is formed by the assembly of tubulin-like FtsZ1 and FtsZ2 proteins. ARC6 is a key chloroplast division protein that interacts with the Z ring. ARC6 spans the inner envelope membrane, is known to stabilize or maintain the Z ring, and anchors the Z ring to the inner membrane through interaction with FtsZ2. The underlying mechanism of Z-ring stabilization is not well understood. Here, biochemical and structural characterization of ARC6 was conducted using light scattering, sedimentation, and light and transmission electron microscopy. The recombinant protein was purified as a dimer. The results indicated that a truncated form of ARC6 (tARC6), representing the stromal portion of ARC6, affects FtsZ2 assembly without forming higher-order structures, and exerts its effect via FtsZ2 dynamics. tARC6 prevented GDP-induced FtsZ2 disassembly and caused a significant net increase in FtsZ2 assembly when GDP was present. Single particle analysis and 3D reconstruction were performed to elucidate the structural basis of ARC6 activity. Together, the data reveal that a dimeric form of tARC6 binds to FtsZ2 filaments and does not increase FtsZ polymerization rates but rather inhibits GDP-associated FtsZ2 disassembly. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

The role of topography on catchment‐scale water residence time

Science.gov (United States)

McGuire, K.J.; McDonnell, Jeffery J.; Weiler, M.; Kendall, C.; McGlynn, B.L.; Welker, J.M.; Seibert, J.

2005-01-01

The age, or residence time, of water is a fundamental descriptor of catchment hydrology, revealing information about the storage, flow pathways, and source of water in a single integrated measure. While there has been tremendous recent interest in residence time estimation to characterize watersheds, there are relatively few studies that have quantified residence time at the watershed scale, and fewer still that have extended those results beyond single catchments to larger landscape scales. We examined topographic controls on residence time for seven catchments (0.085–62.4 km2) that represent diverse geologic and geomorphic conditions in the western Cascade Mountains of Oregon. Our primary objective was to determine the dominant physical controls on catchment‐scale water residence time and specifically test the hypothesis that residence time is related to the size of the basin. Residence times were estimated by simple convolution models that described the transfer of precipitation isotopic composition to the stream network. We found that base flow mean residence times for exponential distributions ranged from 0.8 to 3.3 years. Mean residence time showed no correlation to basin area (r2 organization (i.e., topography) rather than basin area controls catchment‐scale transport. Results from this study may provide a framework for describing scale‐invariant transport across climatic and geologic conditions, whereby the internal form and structure of the basin defines the first‐order control on base flow residence time.

Evidence of the Disassembly of α-Cyclodextrin-octylamine Inclusion Compounds Conjugated to Gold Nanoparticles via Thermal and Photothermal Effects

Directory of Open Access Journals (Sweden)

Nataly Silva

2016-10-01

Full Text Available Cyclodextrin (CD molecules form inclusion compounds (ICs, generating dimers that are capable of encapsulating molecules derived from long-chain hydrocarbons. The aim of this study is to evaluate the structural changes experienced by ICs in solution with increasing temperatures. For this, a nuclear magnetic resonance (1H-NMR titration was performed to determinate the stoichiometric α-cyclodextrin (α-CD:octylamine (OA 2:1 and binding constant (k = 2.16 M−2 of ICs. Solution samples of α-CD-OA ICs conjugated with gold nanoparticles (AuNPs were prepared, and 1H-NMR spectra at different temperatures were recorded. Comparatively, 1H-NMR spectra of the sample irradiated with a laser with tunable wavelengths, with plasmons of conjugated AuNPs, were recorded. In this work, we present evidence of the disassembly of ICs conjugated with AuNPs. Thermal studies demonstrated that, at 114 °C, there are reversible rearrangements of the host and guests in the ICs in a solid state. Migration movements of the guest molecules from the CD cavity were monitored via temperature-dependent 1H-NMR, and were verified comparing the chemical shifts of octylamine dissolved in deuterated dimethylsulfoxide (DMSO-d6 with the OA molecule included in α-CD dissolved in the same solvent. It was observed that, at 117 °C, OA exited the α-CD cavity. CD IC dimer disassembly was also observed when the sample was irradiated with green laser light.

Characteristic time scales for diffusion processes through layers and across interfaces

Science.gov (United States)

Carr, Elliot J.

2018-04-01

This paper presents a simple tool for characterizing the time scale for continuum diffusion processes through layered heterogeneous media. This mathematical problem is motivated by several practical applications such as heat transport in composite materials, flow in layered aquifers, and drug diffusion through the layers of the skin. In such processes, the physical properties of the medium vary across layers and internal boundary conditions apply at the interfaces between adjacent layers. To characterize the time scale, we use the concept of mean action time, which provides the mean time scale at each position in the medium by utilizing the fact that the transition of the transient solution of the underlying partial differential equation model, from initial state to steady state, can be represented as a cumulative distribution function of time. Using this concept, we define the characteristic time scale for a multilayer diffusion process as the maximum value of the mean action time across the layered medium. For given initial conditions and internal and external boundary conditions, this approach leads to simple algebraic expressions for characterizing the time scale that depend on the physical and geometrical properties of the medium, such as the diffusivities and lengths of the layers. Numerical examples demonstrate that these expressions provide useful insight into explaining how the parameters in the model affect the time it takes for a multilayer diffusion process to reach steady state.

Wind power impacts and electricity storage - a time scale perspective

DEFF Research Database (Denmark)

Hedegaard, Karsten; Meibom, Peter

2012-01-01

Integrating large amounts of wind power in energy systems poses balancing challenges due to the variable and only partly predictable nature of wind. The challenges cover different time scales from intra-hour, intra-day/day-ahead to several days and seasonal level. Along with flexible electricity...... demand options, various electricity storage technologies are being discussed as candidates for contributing to large-scale wind power integration and these also differ in terms of the time scales at which they can operate. In this paper, using the case of Western Denmark in 2025 with an expected 57% wind...... power penetration, wind power impacts on different time scales are analysed. Results show consecutive negative and high net load period lengths indicating a significant potential for flexibility measures capable of charging/activating demand and discharging/inactivating demand in periods of 1 h to one...

Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

Science.gov (United States)

Kniss, Andreas; Schuetz, Denise; Kazemi, Sina; Pluska, Lukas; Spindler, Philipp E; Rogov, Vladimir V; Husnjak, Koraljka; Dikic, Ivan; Güntert, Peter; Sommer, Thomas; Prisner, Thomas F; Dötsch, Volker

2018-02-06

Ubiquitination is the most versatile posttranslational modification. The information is encoded by linkage type as well as chain length, which are translated by ubiquitin binding domains into specific signaling events. Chain topology determines the conformational space of a ubiquitin chain and adds an additional regulatory layer to this ubiquitin code. In particular, processes that modify chain length will be affected by chain conformations as they require access to the elongation or cleavage sites. We investigated conformational distributions in the context of chain elongation and disassembly using pulsed electron-electron double resonance spectroscopy in combination with molecular modeling. Analysis of the conformational space of diubiquitin revealed conformational selection or remodeling as mechanisms for chain recognition during elongation or hydrolysis, respectively. Chain elongation to tetraubiquitin increases the sampled conformational space, suggesting that a high intrinsic flexibility of K48-linked chains may contribute to efficient proteasomal degradation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Disassembly of an arch bridge deformed due to landslide activity and the replacement of a new bridge in the same site. Jisuberi ni yori henkei shita arch bashi no kaitai to shinbashi no kakekae

Energy Technology Data Exchange (ETDEWEB)

Sano, S; Morimoto, C; Tomoda, T; Mizukawa, Y; Onushi, M; Ito, T [Kawasaki Heavy Industries, Ltd., Tokyo (Japan)

1991-10-20

This report describes the replacement process of an arch bridge deformed due to landslide activity, selection and contents of the disassembly method, and configuration of the new bridge and its design method. The Ryugu Bridge had been damaged by landslides over an extended period. It was a deck arch bridge having originally a span of 74 meters, but it had shortened by 424 mm due to landslide activity during 14 years since its completion. Then it was decided to be replaced by a new bridge having an adjustable structure to support the movement of its abutments. As disassembly of the deformed arch bridge could be dangerous, the best methodology was studied, and the disassembly was carried out by the cable method. The new bridge had box-girder parts in both side of the main truss, so as to be adjustable to the change of the span length, and the bridge was designed for a working life of 50 years if the bearing supports and expansion joints were reset every 10 years. Concerning the connecting parts between the box-girder and the main truss, appropriateness of the sectional configuration was verified by FEM analysis. 9 refs., 18 figs., 2 tab.

New time scale based k-epsilon model for near-wall turbulence

Science.gov (United States)

Yang, Z.; Shih, T. H.

1993-01-01

A k-epsilon model is proposed for wall bonded turbulent flows. In this model, the eddy viscosity is characterized by a turbulent velocity scale and a turbulent time scale. The time scale is bounded from below by the Kolmogorov time scale. The dissipation equation is reformulated using this time scale and no singularity exists at the wall. The damping function used in the eddy viscosity is chosen to be a function of R(sub y) = (k(sup 1/2)y)/v instead of y(+). Hence, the model could be used for flows with separation. The model constants used are the same as in the high Reynolds number standard k-epsilon model. Thus, the proposed model will be also suitable for flows far from the wall. Turbulent channel flows at different Reynolds numbers and turbulent boundary layer flows with and without pressure gradient are calculated. Results show that the model predictions are in good agreement with direct numerical simulation and experimental data.

The Second Noether Theorem on Time Scales

Directory of Open Access Journals (Sweden)

Agnieszka B. Malinowska

2013-01-01

Full Text Available We extend the second Noether theorem to variational problems on time scales. As corollaries we obtain the classical second Noether theorem, the second Noether theorem for the h-calculus and the second Noether theorem for the q-calculus.

Scale and time dependence of serial correlations in word-length time series of written texts

Science.gov (United States)

Rodriguez, E.; Aguilar-Cornejo, M.; Femat, R.; Alvarez-Ramirez, J.

2014-11-01

This work considered the quantitative analysis of large written texts. To this end, the text was converted into a time series by taking the sequence of word lengths. The detrended fluctuation analysis (DFA) was used for characterizing long-range serial correlations of the time series. To this end, the DFA was implemented within a rolling window framework for estimating the variations of correlations, quantified in terms of the scaling exponent, strength along the text. Also, a filtering derivative was used to compute the dependence of the scaling exponent relative to the scale. The analysis was applied to three famous English-written literary narrations; namely, Alice in Wonderland (by Lewis Carrol), Dracula (by Bram Stoker) and Sense and Sensibility (by Jane Austen). The results showed that high correlations appear for scales of about 50-200 words, suggesting that at these scales the text contains the stronger coherence. The scaling exponent was not constant along the text, showing important variations with apparent cyclical behavior. An interesting coincidence between the scaling exponent variations and changes in narrative units (e.g., chapters) was found. This suggests that the scaling exponent obtained from the DFA is able to detect changes in narration structure as expressed by the usage of words of different lengths.

Multi-Scale Dissemination of Time Series Data

DEFF Research Database (Denmark)

Guo, Qingsong; Zhou, Yongluan; Su, Li

2013-01-01

In this paper, we consider the problem of continuous dissemination of time series data, such as sensor measurements, to a large number of subscribers. These subscribers fall into multiple subscription levels, where each subscription level is specified by the bandwidth constraint of a subscriber......, which is an abstract indicator for both the physical limits and the amount of data that the subscriber would like to handle. To handle this problem, we propose a system framework for multi-scale time series data dissemination that employs a typical tree-based dissemination network and existing time...

Time-Scale Invariant Audio Data Embedding

Directory of Open Access Journals (Sweden)

Mansour Mohamed F

2003-01-01

Full Text Available We propose a novel algorithm for high-quality data embedding in audio. The algorithm is based on changing the relative length of the middle segment between two successive maximum and minimum peaks to embed data. Spline interpolation is used to change the lengths. To ensure smooth monotonic behavior between peaks, a hybrid orthogonal and nonorthogonal wavelet decomposition is used prior to data embedding. The possible data embedding rates are between 20 and 30 bps. However, for practical purposes, we use repetition codes, and the effective embedding data rate is around 5 bps. The algorithm is invariant after time-scale modification, time shift, and time cropping. It gives high-quality output and is robust to mp3 compression.

Antipersistent dynamics in short time scale variability of self-potential signals

Directory of Open Access Journals (Sweden)

M. Ragosta

2000-06-01

Full Text Available Time scale properties of self-potential signals are investigated through the analysis of the second order structure function (variogram, a powerful tool to investigate the spatial and temporal variability of observational data. In this work we analyse two sequences of self-potential values measured by means of a geophysical monitoring array located in a seismically active area of Southern Italy. The range of scales investigated goes from a few minutes to several days. It is shown that signal fluctuations are characterised by two time scale ranges in which self-potential variability appears to follow slightly different dynamical behaviours. Results point to the presence of fractal, non stationary features expressing a long term correlation with scaling coefficients which are the clue of stabilising mechanisms. In the scale ranges in which the series show scale invariant behaviour, self-potentials evolve like fractional Brownian motions with anticorrelated increments typical of processes regulated by negative feedback mechanisms (antipersistence. On scales below about 6 h the strength of such an antipersistence appears to be slightly greater than that observed on larger time scales where the fluctuations are less efficiently stabilised.

Backpropagation and ordered derivatives in the time scales calculus.

Science.gov (United States)

Seiffertt, John; Wunsch, Donald C

2010-08-01

Backpropagation is the most widely used neural network learning technique. It is based on the mathematical notion of an ordered derivative. In this paper, we present a formulation of ordered derivatives and the backpropagation training algorithm using the important emerging area of mathematics known as the time scales calculus. This calculus, with its potential for application to a wide variety of inter-disciplinary problems, is becoming a key area of mathematics. It is capable of unifying continuous and discrete analysis within one coherent theoretical framework. Using this calculus, we present here a generalization of backpropagation which is appropriate for cases beyond the specifically continuous or discrete. We develop a new multivariate chain rule of this calculus, define ordered derivatives on time scales, prove a key theorem about them, and derive the backpropagation weight update equations for a feedforward multilayer neural network architecture. By drawing together the time scales calculus and the area of neural network learning, we present the first connection of two major fields of research.

A Group Simulation of the Development of the Geologic Time Scale.

Science.gov (United States)

Bennington, J. Bret

2000-01-01

Explains how to demonstrate to students that the relative dating of rock layers is redundant. Uses two column diagrams to simulate stratigraphic sequences from two different geological time scales and asks students to complete the time scale. (YDS)

Acoustically Triggered Disassembly of Multilayered Polyelectrolyte Thin Films through Gigahertz Resonators for Controlled Drug Release Applications

Directory of Open Access Journals (Sweden)

Zhixin Zhang

2016-11-01

Full Text Available Controlled drug release has a high priority for the development of modern medicine and biochemistry. To develop a versatile method for controlled release, a miniaturized acoustic gigahertz (GHz resonator is designed and fabricated which can transfer electric supply to mechanical vibrations. By contacting with liquid, the GHz resonator directly excites streaming flows and induces physical shear stress to tear the multilayered polyelectrolyte (PET thin films. Due to the ultra-high working frequency, the shear stress is greatly intensified, which results in a controlled disassembling of the PET thin films. This technique is demonstrated as an effective method to trigger and control the drug release. Both theory analysis and controlled release experiments prove the thin film destruction and the drug release.

Improvement of the in vivo cellular repopulation of decellularized cardiovascular tissues by a detergent-free, non-proteolytic, actin-disassembling regimen.

Science.gov (United States)

Assmann, Alexander; Struß, Marc; Schiffer, Franziska; Heidelberg, Friederike; Munakata, Hiroshi; Timchenko, Elena V; Timchenko, Pavel E; Kaufmann, Tim; Huynh, Khon; Sugimura, Yukiharu; Leidl, Quentin; Pinto, Antonio; Stoldt, Volker R; Lichtenberg, Artur; Akhyari, Payam

2017-12-01

Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particularly focusing on their bio-functionality. Rat aortic conduits (rAoC; n = 89) and porcine aortic valve samples (n = 106) are decellularized using detergents (group DET) or the BIO regimen. BIO decellularization results in effective elimination of cellular proteins and significantly improves removal of DNA as compared with group DET, while the extracellular matrix (ECM) structure as well as mechanical properties are preserved. The architecture of rAoC in group BIO allows for improved bio-functionalization with fibronectin (FN) in a standardized rat implantation model: BIO treatment significantly increases speed and amount of autologous medial cellular repopulation in vivo (p < 0.001) and decreases the formation of hyperplastic intima (p < 0.001) as compared with FN-coated DET-decellularized grafts. Moreover, there are no signs of infiltration with inflammatory cells. The present biological, detergent-free, non-proteolytic regimen balances effective decellularization and ECM preservation in cardiovascular grafts, and provides optimized bio-functionality. Additionally, this study implies that the actin-disassembling regimen may be a promising approach for bioengineering of acellular scaffolds from other muscular tissues, as for example myocardium or intestine. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Multidimensional scaling of musical time estimations.

Science.gov (United States)

Cocenas-Silva, Raquel; Bueno, José Lino Oliveira; Molin, Paul; Bigand, Emmanuel

2011-06-01

The aim of this study was to identify the psycho-musical factors that govern time evaluation in Western music from baroque, classic, romantic, and modern repertoires. The excerpts were previously found to represent variability in musical properties and to induce four main categories of emotions. 48 participants (musicians and nonmusicians) freely listened to 16 musical excerpts (lasting 20 sec. each) and grouped those that seemed to have the same duration. Then, participants associated each group of excerpts to one of a set of sine wave tones varying in duration from 16 to 24 sec. Multidimensional scaling analysis generated a two-dimensional solution for these time judgments. Musical excerpts with high arousal produced an overestimation of time, and affective valence had little influence on time perception. The duration was also overestimated when tempo and loudness were higher, and to a lesser extent, timbre density. In contrast, musical tension had little influence.

Measures of spike train synchrony for data with multiple time scales

NARCIS (Netherlands)

Satuvuori, Eero; Mulansky, Mario; Bozanic, Nebojsa; Malvestio, Irene; Zeldenrust, Fleur; Lenk, Kerstin; Kreuz, Thomas

2017-01-01

Background Measures of spike train synchrony are widely used in both experimental and computational neuroscience. Time-scale independent and parameter-free measures, such as the ISI-distance, the SPIKE-distance and SPIKE-synchronization, are preferable to time scale parametric measures, since by

Multiple time scale analysis of pressure oscillations in solid rocket motors

Science.gov (United States)

Ahmed, Waqas; Maqsood, Adnan; Riaz, Rizwan

2018-03-01

In this study, acoustic pressure oscillations for single and coupled longitudinal acoustic modes in Solid Rocket Motor (SRM) are investigated using Multiple Time Scales (MTS) method. Two independent time scales are introduced. The oscillations occur on fast time scale whereas the amplitude and phase changes on slow time scale. Hopf bifurcation is employed to investigate the properties of the solution. The supercritical bifurcation phenomenon is observed for linearly unstable system. The amplitude of the oscillations result from equal energy gain and loss rates of longitudinal acoustic modes. The effect of linear instability and frequency of longitudinal modes on amplitude and phase of oscillations are determined for both single and coupled modes. For both cases, the maximum amplitude of oscillations decreases with the frequency of acoustic mode and linear instability of SRM. The comparison of analytical MTS results and numerical simulations demonstrate an excellent agreement.

Decommissioning of nuclear facilities: Decontamination, disassembly and waste management

International Nuclear Information System (INIS)

1983-01-01

The term 'decommissioning', as used within the nuclear industry, means the actions taken at the end of a facility's useful life to retire the facility from service in a manner that provides adequate protection for the health and safety of the decommissioning workers, the general public, and for the environment. These actions can range from merely closing down the facility and a minimal removal of radioactive material coupled with continuing maintenance and surveillance, to a complete removal of residual radioactivity in excess of levels acceptable for unrestricted use of the facility and its site. This latter condition, unrestricted use, is the ultimate goal of all decommissioning actions at retired nuclear facilities. The purpose of this report is to provide an information base on the considerations important to decommissioning, the methods available for decontamination and disassembly of a nuclear facility, the management of the resulting radioactive wastes, and the areas of decommissioning methodology where improvements might be made. Specific sections are devoted to each of these topics, and conclusions are presented concerning the present status of each topic. A summary of past decommissioning experience in Member States is presented in the Appendix. The report, with its discussions of necessary considerations, available operational methods, and waste management practices, together with supporting references, provides an appreciation of the activities that comprise decommissioning of nuclear facilities. It is anticipated that the information presented in the report should prove useful to persons concerned with the development of plans for the decommissioning of retired nuclear facilities

Nucleolus disassembly and distribution of segregated nucleolar material in prophase of root-tip meristematic cells in Triticum aestivum L.

Directory of Open Access Journals (Sweden)

Wang Jianyue

2015-01-01

Full Text Available This paper presents details of the process of nucleolar disassembly, studied by conventional transmission electron microscopy (TEM in wheat root cells. In early prophase, chromatin condensation and irregular nucleolar morphology are observed, with many small particles appearing around the nucleolus. In middle prophase, the nucleolus radiates outwards; in late prophase, the fine structure of the nucleolus disappears and nucleolar material diffuses away. Using “en bloc” silver-staining to distinguish between nucleoli and chromatin, we observed that the dispersed nucleolar material aggregates around the chromatin, forming a sheath-like perichromosomal structure that coats the chromosomes in late prophase.

Role of a reducing environment in disassembly of the herpesvirus tegument

Energy Technology Data Exchange (ETDEWEB)

Newcomb, William W. [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States); Jones, Lisa M. [Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130 (United States); Dee, Alexander [Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 (United States); Chaudhry, Farid [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States); Brown, Jay C., E-mail: JCB2G@VIRGINIA.EDU [Department of Microbiology Immunology and Cancer Biology, University of Virginia Health System, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave. Charlottesville, VA 22908 (United States)

2012-09-15

Initiation of infection by herpes family viruses involves a step in which most of the virus tegument becomes detached from the capsid. Detachment takes place in the host cell cytosol near the virus entry site and it is followed by dispersal of tegument proteins and disappearance of the tegument as a distinct entity. Here we describe the results of experiments designed to test the idea that the reducing environment of the cytosol may contribute to tegument detachment and disassembly. Non-ionic detergent was used to remove the membrane of purified herpes simplex virus under control and reducing conditions. The effects on the tegument were then examined by SDS-PAGE and electron microscopy. Protein analysis demonstrated that most major tegument proteins were removed under both oxidizing and reducing conditions except for UL49 which required a reducing environment. It is proposed therefore that the reducing conditions in the cytosol are involved in removal of UL49 protein. Electron microscopic analysis revealed that capsids produced under oxidizing conditions contained a coating of protein that was absent in reduced virions and which correlated uniquely with the presence of UL49. This capsid-associated layer is suggested to be the location of UL49 in the extracted virion.

Prewhitening of hydroclimatic time series? Implications for inferred change and variability across time scales

Science.gov (United States)

Razavi, Saman; Vogel, Richard

2018-02-01

Prewhitening, the process of eliminating or reducing short-term stochastic persistence to enable detection of deterministic change, has been extensively applied to time series analysis of a range of geophysical variables. Despite the controversy around its utility, methodologies for prewhitening time series continue to be a critical feature of a variety of analyses including: trend detection of hydroclimatic variables and reconstruction of climate and/or hydrology through proxy records such as tree rings. With a focus on the latter, this paper presents a generalized approach to exploring the impact of a wide range of stochastic structures of short- and long-term persistence on the variability of hydroclimatic time series. Through this approach, we examine the impact of prewhitening on the inferred variability of time series across time scales. We document how a focus on prewhitened, residual time series can be misleading, as it can drastically distort (or remove) the structure of variability across time scales. Through examples with actual data, we show how such loss of information in prewhitened time series of tree rings (so-called "residual chronologies") can lead to the underestimation of extreme conditions in climate and hydrology, particularly droughts, reconstructed for centuries preceding the historical period.

THEORETICAL REVIEW The Hippocampus, Time, and Memory Across Scales

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Howard, Marc W.; Eichenbaum, Howard

2014-01-01

A wealth of experimental studies with animals have offered insights about how neural networks within the hippocampus support the temporal organization of memories. These studies have revealed the existence of “time cells” that encode moments in time, much as the well-known “place cells” map locations in space. Another line of work inspired by human behavioral studies suggests that episodic memories are mediated by a state of temporal context that changes gradually over long time scales, up to at least a few thousand seconds. In this view, the “mental time travel” hypothesized to support the experience of episodic memory corresponds to a “jump back in time” in which a previous state of temporal context is recovered. We suggest that these 2 sets of findings could be different facets of a representation of temporal history that maintains a record at the last few thousand seconds of experience. The ability to represent long time scales comes at the cost of discarding precise information about when a stimulus was experienced—this uncertainty becomes greater for events further in the past. We review recent computational work that describes a mechanism that could construct such a scale-invariant representation. Taken as a whole, this suggests the hippocampus plays its role in multiple aspects of cognition by representing events embedded in a general spatiotemporal context. The representation of internal time can be useful across nonhippocampal memory systems. PMID:23915126

Fractional Sobolev’s Spaces on Time Scales via Conformable Fractional Calculus and Their Application to a Fractional Differential Equation on Time Scales

Directory of Open Access Journals (Sweden)

Yanning Wang

2016-01-01

Full Text Available Using conformable fractional calculus on time scales, we first introduce fractional Sobolev spaces on time scales, characterize them, and define weak conformable fractional derivatives. Second, we prove the equivalence of some norms in the introduced spaces and derive their completeness, reflexivity, uniform convexity, and compactness of some imbeddings, which can be regarded as a novelty item. Then, as an application, we present a recent approach via variational methods and critical point theory to obtain the existence of solutions for a p-Laplacian conformable fractional differential equation boundary value problem on time scale T:  Tα(Tαup-2Tα(u(t=∇F(σ(t,u(σ(t, Δ-a.e.  t∈a,bTκ2, u(a-u(b=0, Tα(u(a-Tα(u(b=0, where Tα(u(t denotes the conformable fractional derivative of u of order α at t, σ is the forward jump operator, a,b∈T,  01, and F:[0,T]T×RN→R. By establishing a proper variational setting, we obtain three existence results. Finally, we present two examples to illustrate the feasibility and effectiveness of the existence results.

Time scales of solar microwave bursts and scenarios of flare enregy release

International Nuclear Information System (INIS)

Krueger, A.; Kliem, B.; Hildebrandt, J.

1989-01-01

Based on earlier observational evidence that characteristic time scales of different solar microwave burst types are distributed over a wide range (10 -3 -10 4 sec), different mechanisms of energy release have been considered to account for the impulsive flux increase (time scale 3 sec). Among different competing processes the coalescence instability is found to be a promising candidate to combine sufficiently short time scales with substantial energy release. (author). 20 refs.; 1 fig

Multiple dynamical time-scales in networks with hierarchically

Indian Academy of Sciences (India)

Modular networks; hierarchical organization; synchronization. ... we show that such a topological structure gives rise to characteristic time-scale separation ... This suggests a possible functional role of such mesoscopic organization principle in ...

Some Nonlinear Dynamic Inequalities on Time Scales

Indian Academy of Sciences (India)

The aim of this paper is to investigate some nonlinear dynamic inequalities on time scales, which provide explicit bounds on unknown functions. The inequalities given here unify and extend some inequalities in (B G Pachpatte, On some new inequalities related to a certain inequality arising in the theory of differential ...

Multiple time scales of adaptation in auditory cortex neurons.

Science.gov (United States)

Ulanovsky, Nachum; Las, Liora; Farkas, Dina; Nelken, Israel

2004-11-17

Neurons in primary auditory cortex (A1) of cats show strong stimulus-specific adaptation (SSA). In probabilistic settings, in which one stimulus is common and another is rare, responses to common sounds adapt more strongly than responses to rare sounds. This SSA could be a correlate of auditory sensory memory at the level of single A1 neurons. Here we studied adaptation in A1 neurons, using three different probabilistic designs. We showed that SSA has several time scales concurrently, spanning many orders of magnitude, from hundreds of milliseconds to tens of seconds. Similar time scales are known for the auditory memory span of humans, as measured both psychophysically and using evoked potentials. A simple model, with linear dependence on both short-term and long-term stimulus history, provided a good fit to A1 responses. Auditory thalamus neurons did not show SSA, and their responses were poorly fitted by the same model. In addition, SSA increased the proportion of failures in the responses of A1 neurons to the adapting stimulus. Finally, SSA caused a bias in the neuronal responses to unbiased stimuli, enhancing the responses to eccentric stimuli. Therefore, we propose that a major function of SSA in A1 neurons is to encode auditory sensory memory on multiple time scales. This SSA might play a role in stream segregation and in binding of auditory objects over many time scales, a property that is crucial for processing of natural auditory scenes in cats and of speech and music in humans.

Special Issue on Time Scale Algorithms

Science.gov (United States)

2008-01-01

unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 IOP PUBLISHING METROLOGIA Metrologia 45 (2008) doi:10.1088/0026-1394/45/6/E01...special issue of Metrologia presents selected papers from the Fifth International Time Scale Algorithm Symposium (VITSAS), including some of the...scientists, and hosted by the Real Instituto y Observatorio de la Armada (ROA) in San Fernando, Spain, whose staff further enhanced their nation’s high

A model for AGN variability on multiple time-scales

Science.gov (United States)

Sartori, Lia F.; Schawinski, Kevin; Trakhtenbrot, Benny; Caplar, Neven; Treister, Ezequiel; Koss, Michael J.; Urry, C. Megan; Zhang, C. E.

2018-05-01

We present a framework to link and describe active galactic nuclei (AGN) variability on a wide range of time-scales, from days to billions of years. In particular, we concentrate on the AGN variability features related to changes in black hole fuelling and accretion rate. In our framework, the variability features observed in different AGN at different time-scales may be explained as realisations of the same underlying statistical properties. In this context, we propose a model to simulate the evolution of AGN light curves with time based on the probability density function (PDF) and power spectral density (PSD) of the Eddington ratio (L/LEdd) distribution. Motivated by general galaxy population properties, we propose that the PDF may be inspired by the L/LEdd distribution function (ERDF), and that a single (or limited number of) ERDF+PSD set may explain all observed variability features. After outlining the framework and the model, we compile a set of variability measurements in terms of structure function (SF) and magnitude difference. We then combine the variability measurements on a SF plot ranging from days to Gyr. The proposed framework enables constraints on the underlying PSD and the ability to link AGN variability on different time-scales, therefore providing new insights into AGN variability and black hole growth phenomena.

Fractional dynamic calculus and fractional dynamic equations on time scales

CERN Document Server

Georgiev, Svetlin G

2018-01-01

Pedagogically organized, this monograph introduces fractional calculus and fractional dynamic equations on time scales in relation to mathematical physics applications and problems. Beginning with the definitions of forward and backward jump operators, the book builds from Stefan Hilger’s basic theories on time scales and examines recent developments within the field of fractional calculus and fractional equations. Useful tools are provided for solving differential and integral equations as well as various problems involving special functions of mathematical physics and their extensions and generalizations in one and more variables. Much discussion is devoted to Riemann-Liouville fractional dynamic equations and Caputo fractional dynamic equations.  Intended for use in the field and designed for students without an extensive mathematical background, this book is suitable for graduate courses and researchers looking for an introduction to fractional dynamic calculus and equations on time scales. .

Time-scale invariance as an emergent property in a perceptron with realistic, noisy neurons.

Science.gov (United States)

Buhusi, Catalin V; Oprisan, Sorinel A

2013-05-01

In most species, interval timing is time-scale invariant: errors in time estimation scale up linearly with the estimated duration. In mammals, time-scale invariance is ubiquitous over behavioral, lesion, and pharmacological manipulations. For example, dopaminergic drugs induce an immediate, whereas cholinergic drugs induce a gradual, scalar change in timing. Behavioral theories posit that time-scale invariance derives from particular computations, rules, or coding schemes. In contrast, we discuss a simple neural circuit, the perceptron, whose output neurons fire in a clockwise fashion based on the pattern of coincidental activation of its input neurons. We show numerically that time-scale invariance emerges spontaneously in a perceptron with realistic neurons, in the presence of noise. Under the assumption that dopaminergic drugs modulate the firing of input neurons, and that cholinergic drugs modulate the memory representation of the criterion time, we show that a perceptron with realistic neurons reproduces the pharmacological clock and memory patterns, and their time-scale invariance, in the presence of noise. These results suggest that rather than being a signature of higher order cognitive processes or specific computations related to timing, time-scale invariance may spontaneously emerge in a massively connected brain from the intrinsic noise of neurons and circuits, thus providing the simplest explanation for the ubiquity of scale invariance of interval timing. Copyright © 2013 Elsevier B.V. All rights reserved.

Liquidity spillover in international stock markets through distinct time scales.

Science.gov (United States)

Righi, Marcelo Brutti; Vieira, Kelmara Mendes

2014-01-01

This paper identifies liquidity spillovers through different time scales based on a wavelet multiscaling method. We decompose daily data from U.S., British, Brazilian and Hong Kong stock markets indices in order to calculate the scale correlation between their illiquidities. The sample is divided in order to consider non-crisis, sub-prime crisis and Eurozone crisis. We find that there are changes in correlations of distinct scales and different periods. Association in finest scales is smaller than in coarse scales. There is a rise on associations in periods of crisis. In frequencies, there is predominance for significant distinctions involving the coarsest scale, while for crises periods there is predominance for distinctions on the finest scale.

Towards a High-resolution Time Scale for the Early Devonian

Science.gov (United States)

Dekkers, M. J.; da Silva, A. C.

2017-12-01

High-resolution time scales are crucial to understand Earth's history in detail. The construction of a robust geological time scale, however, inevitably becomes increasingly harder further back in time. Uncertainties associated with anchor radiometric ages increase in size, not speaking of the mere presence of suitable datable strata. However, durations of stages can be tightly constrained by making use of cyclic expressions in sediments, an approach that revolutionized the Cenozoic time scale. When precisely determined durations are stitched together, ultimately, a very precise time scale is the result. For the Mesozoic and Paleozoic an astronomical solution as a tuning target is not available but the dominant periods of eccentricity, obliquity and precession are reasonably well constrained for the entire Phanerozoic which enables their detection by means of spectral analysis. Eccentricity is time-invariant and is used as the prime building block. Here we focus on the Early Devonian, on its lowermost three stages: the Lochkovian, Pragian and Emsian. The uncertainties on the Devonian stage boundaries are currently in the order of several millions of years. The preservation of climatic cycles in diagenetically or even anchimetamorphically affected successions, however, is essential. The fit of spectral peak ratios with those calculated for orbital cycles, is classically used as a strong argument for a preserved climatic signal. Here we use primarily the low field magnetic susceptibility (MS) as proxy parameter, supported by gamma-ray spectrometry to test for consistency. Continuous Wavelet Transform, Evolutive Harmonic Analysis, Multitaper Method, and Average Spectral Misfit are used to reach an optimal astronomical interpretation. We report on classic Early Devonian sections from the Czech Republic: the Pozar-CS (Lochkovian and Pragian), Pod Barrandovem (Pragian and Lower Emsian), and Zlichov (Middle-Upper Emsian). Also a Middle-Upper Emsian section from the US

High-resolution time-frequency representation of EEG data using multi-scale wavelets

Science.gov (United States)

Li, Yang; Cui, Wei-Gang; Luo, Mei-Lin; Li, Ke; Wang, Lina

2017-09-01

An efficient time-varying autoregressive (TVAR) modelling scheme that expands the time-varying parameters onto the multi-scale wavelet basis functions is presented for modelling nonstationary signals and with applications to time-frequency analysis (TFA) of electroencephalogram (EEG) signals. In the new parametric modelling framework, the time-dependent parameters of the TVAR model are locally represented by using a novel multi-scale wavelet decomposition scheme, which can allow the capability to capture the smooth trends as well as track the abrupt changes of time-varying parameters simultaneously. A forward orthogonal least square (FOLS) algorithm aided by mutual information criteria are then applied for sparse model term selection and parameter estimation. Two simulation examples illustrate that the performance of the proposed multi-scale wavelet basis functions outperforms the only single-scale wavelet basis functions or Kalman filter algorithm for many nonstationary processes. Furthermore, an application of the proposed method to a real EEG signal demonstrates the new approach can provide highly time-dependent spectral resolution capability.

Quantum universe on extremely small space-time scales

International Nuclear Information System (INIS)

Kuzmichev, V.E.; Kuzmichev, V.V.

2010-01-01

The semiclassical approach to the quantum geometrodynamical model is used for the description of the properties of the Universe on extremely small space-time scales. Under this approach, the matter in the Universe has two components of the quantum nature which behave as antigravitating fluids. The first component does not vanish in the limit h → 0 and can be associated with dark energy. The second component is described by an extremely rigid equation of state and goes to zero after the transition to large spacetime scales. On small space-time scales, this quantum correction turns out to be significant. It determines the geometry of the Universe near the initial cosmological singularity point. This geometry is conformal to a unit four-sphere embedded in a five-dimensional Euclidean flat space. During the consequent expansion of the Universe, when reaching the post-Planck era, the geometry of the Universe changes into that conformal to a unit four-hyperboloid in a five-dimensional Lorentzsignatured flat space. This agrees with the hypothesis about the possible change of geometry after the origin of the expanding Universe from the region near the initial singularity point. The origin of the Universe can be interpreted as a quantum transition of the system from a region in the phase space forbidden for the classical motion, but where a trajectory in imaginary time exists, into a region, where the equations of motion have the solution which describes the evolution of the Universe in real time. Near the boundary between two regions, from the side of real time, the Universe undergoes almost an exponential expansion which passes smoothly into the expansion under the action of radiation dominating over matter which is described by the standard cosmological model.

Bridging time scales in cellular decision making with a stochastic bistable switch

Directory of Open Access Journals (Sweden)

Waldherr Steffen

2010-08-01

Full Text Available Abstract Background Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems. Some of these transformations act over a very long time scale on the cell population level, up to the entire lifespan of the organism. Results In this work, we aim at linking cellular decisions taking place on a time scale of years to decades with the biochemical dynamics in signal transduction and gene regulation, occuring on a time scale of minutes to hours. We show that a stochastic bistable switch forms a viable biochemical mechanism to implement decision processes on long time scales. As a case study, the mechanism is applied to model the initiation of follicle growth in mammalian ovaries, where the physiological time scale of follicle pool depletion is on the order of the organism's lifespan. We construct a simple mathematical model for this process based on experimental evidence for the involved genetic mechanisms. Conclusions Despite the underlying stochasticity, the proposed mechanism turns out to yield reliable behavior in large populations of cells subject to the considered decision process. Our model explains how the physiological time constant may emerge from the intrinsic stochasticity of the underlying gene regulatory network. Apart from ovarian follicles, the proposed mechanism may also be of relevance for other physiological systems where cells take binary decisions over a long time scale.

Earth History databases and visualization - the TimeScale Creator system

Science.gov (United States)

Ogg, James; Lugowski, Adam; Gradstein, Felix

2010-05-01

The "TimeScale Creator" team (www.tscreator.org) and the Subcommission on Stratigraphic Information (stratigraphy.science.purdue.edu) of the International Commission on Stratigraphy (www.stratigraphy.org) has worked with numerous geoscientists and geological surveys to prepare reference datasets for global and regional stratigraphy. All events are currently calibrated to Geologic Time Scale 2004 (Gradstein et al., 2004, Cambridge Univ. Press) and Concise Geologic Time Scale (Ogg et al., 2008, Cambridge Univ. Press); but the array of intercalibrations enable dynamic adjustment to future numerical age scales and interpolation methods. The main "global" database contains over 25,000 events/zones from paleontology, geomagnetics, sea-level and sequence stratigraphy, igneous provinces, bolide impacts, plus several stable isotope curves and image sets. Several regional datasets are provided in conjunction with geological surveys, with numerical ages interpolated using a similar flexible inter-calibration procedure. For example, a joint program with Geoscience Australia has compiled an extensive Australian regional biostratigraphy and a full array of basin lithologic columns with each formation linked to public lexicons of all Proterozoic through Phanerozoic basins - nearly 500 columns of over 9,000 data lines plus hot-curser links to oil-gas reference wells. Other datapacks include New Zealand biostratigraphy and basin transects (ca. 200 columns), Russian biostratigraphy, British Isles regional stratigraphy, Gulf of Mexico biostratigraphy and lithostratigraphy, high-resolution Neogene stable isotope curves and ice-core data, human cultural episodes, and Circum-Arctic stratigraphy sets. The growing library of datasets is designed for viewing and chart-making in the free "TimeScale Creator" JAVA package. This visualization system produces a screen display of the user-selected time-span and the selected columns of geologic time scale information. The user can change the

Disassembling archeology, reassembling the modern world.

Science.gov (United States)

Carruthers, William; Van Damme, Stéphane

2017-09-01

This article provides a substantive discussion of the relevance of the history of archeology to the history of science. At the same time, the article introduces the papers contained in this special issue as exemplars of this relevance. To make its case, the article moves through various themes in the history of archeology that overlap with key issues in the history of science. The article discusses the role and tension of regimes of science in antiquarian and archeological practices, and also considers issues of scale and place, particularly in relation to the field. Additionally, the piece attends to issues of professionalization and the constitution of an archeological public, at the same time as discussing issues of empire, colonialism, and the circulation of knowledge. Meanwhile, enriching discussions within and beyond the history of science, the article discusses the history of archeology and its relationship with museums, collecting, and material culture and materiality. Finally, the piece discusses the relationship of the history of archeology with wider discussions about scientific ethics. In conclusion, the article questions whether we should speak of 'the history of archeology' at all.

Influence of the time scale on the construction of financial networks.

Science.gov (United States)

Emmert-Streib, Frank; Dehmer, Matthias

2010-09-30

In this paper we investigate the definition and formation of financial networks. Specifically, we study the influence of the time scale on their construction. For our analysis we use correlation-based networks obtained from the daily closing prices of stock market data. More precisely, we use the stocks that currently comprise the Dow Jones Industrial Average (DJIA) and estimate financial networks where nodes correspond to stocks and edges correspond to none vanishing correlation coefficients. That means only if a correlation coefficient is statistically significant different from zero, we include an edge in the network. This construction procedure results in unweighted, undirected networks. By separating the time series of stock prices in non-overlapping intervals, we obtain one network per interval. The length of these intervals corresponds to the time scale of the data, whose influence on the construction of the networks will be studied in this paper. Numerical analysis of four different measures in dependence on the time scale for the construction of networks allows us to gain insights about the intrinsic time scale of the stock market with respect to a meaningful graph-theoretical analysis.

Time-sliced perturbation theory for large scale structure I: general formalism

Energy Technology Data Exchange (ETDEWEB)

Blas, Diego; Garny, Mathias; Sibiryakov, Sergey [Theory Division, CERN, CH-1211 Genève 23 (Switzerland); Ivanov, Mikhail M., E-mail: diego.blas@cern.ch, E-mail: mathias.garny@cern.ch, E-mail: mikhail.ivanov@cern.ch, E-mail: sergey.sibiryakov@cern.ch [FSB/ITP/LPPC, École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne (Switzerland)

2016-07-01

We present a new analytic approach to describe large scale structure formation in the mildly non-linear regime. The central object of the method is the time-dependent probability distribution function generating correlators of the cosmological observables at a given moment of time. Expanding the distribution function around the Gaussian weight we formulate a perturbative technique to calculate non-linear corrections to cosmological correlators, similar to the diagrammatic expansion in a three-dimensional Euclidean quantum field theory, with time playing the role of an external parameter. For the physically relevant case of cold dark matter in an Einstein-de Sitter universe, the time evolution of the distribution function can be found exactly and is encapsulated by a time-dependent coupling constant controlling the perturbative expansion. We show that all building blocks of the expansion are free from spurious infrared enhanced contributions that plague the standard cosmological perturbation theory. This paves the way towards the systematic resummation of infrared effects in large scale structure formation. We also argue that the approach proposed here provides a natural framework to account for the influence of short-scale dynamics on larger scales along the lines of effective field theory.

Ignition in net for different energy confinement time scalings

International Nuclear Information System (INIS)

Johner, J.; Prevot, F.

1988-06-01

A zero-dimensional profile dependent model is used to assess the feasibility of ignition in the extended version of NET. Five recent scalings for the energy confinement time (Goldston, Kaye All, Kaye Big, Shimomura-Odajima, Rebut-Lallia) are compared in the frame of two different scenarii, i.e., H-mode with a flat density profile or L-mode with a peaked density profile. For the flat density H-mode case, ignition is accessible with none of the scalings except Rebut-Lallia's. For the peaked density L-mode case, ignition is accessible with none of the scalings except Rebut-Lallia's. For the two Kaye's scalings, ignition is forbidden in H-mode even with the peaked density profile. For the Rebut-Lallia scaling, ignition is allowed in L-mode even with the flat density profile

Structure of Student Time Management Scale (STMS)

Science.gov (United States)

Balamurugan, M.

2013-01-01

With the aim of constructing a Student Time Management Scale (STMS), the initial version was administered and data were collected from 523 standard eleventh students. (Mean age = 15.64). The data obtained were subjected to Reliability and Factor analysis using PASW Statistical software version 18. From 42 items 14 were dropped, resulting in the…

AFSC/ABL: Ugashik sockeye salmon scale time series

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — A time series of scale samples (1956 b?? 2002) collected from adult sockeye salmon returning to Ugashik River were retrieved from the Alaska Department of Fish and...

AFSC/ABL: Naknek sockeye salmon scale time series

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — A time series of scale samples (1956 2002) collected from adult sockeye salmon returning to Naknek River were retrieved from the Alaska Department of Fish and Game....

Understanding relationships among ecosystem services across spatial scales and over time

Science.gov (United States)

Qiu, Jiangxiao; Carpenter, Stephen R.; Booth, Eric G.; Motew, Melissa; Zipper, Samuel C.; Kucharik, Christopher J.; Loheide, Steven P., II; Turner, Monica G.

2018-05-01

Sustaining ecosystem services (ES), mitigating their tradeoffs and avoiding unfavorable future trajectories are pressing social-environmental challenges that require enhanced understanding of their relationships across scales. Current knowledge of ES relationships is often constrained to one spatial scale or one snapshot in time. In this research, we integrated biophysical modeling with future scenarios to examine changes in relationships among eight ES indicators from 2001–2070 across three spatial scales—grid cell, subwatershed, and watershed. We focused on the Yahara Watershed (Wisconsin) in the Midwestern United States—an exemplar for many urbanizing agricultural landscapes. Relationships among ES indicators changed over time; some relationships exhibited high interannual variations (e.g. drainage vs. food production, nitrate leaching vs. net ecosystem exchange) and even reversed signs over time (e.g. perennial grass production vs. phosphorus yield). Robust patterns were detected for relationships among some regulating services (e.g. soil retention vs. water quality) across three spatial scales, but other relationships lacked simple scaling rules. This was especially true for relationships of food production vs. water quality, and drainage vs. number of days with runoff >10 mm, which differed substantially across spatial scales. Our results also showed that local tradeoffs between food production and water quality do not necessarily scale up, so reducing local tradeoffs may be insufficient to mitigate such tradeoffs at the watershed scale. We further synthesized these cross-scale patterns into a typology of factors that could drive changes in ES relationships across scales: (1) effects of biophysical connections, (2) effects of dominant drivers, (3) combined effects of biophysical linkages and dominant drivers, and (4) artificial scale effects, and concluded with management implications. Our study highlights the importance of taking a dynamic

Deviations from uniform power law scaling in nonstationary time series

Science.gov (United States)

Viswanathan, G. M.; Peng, C. K.; Stanley, H. E.; Goldberger, A. L.

1997-01-01

A classic problem in physics is the analysis of highly nonstationary time series that typically exhibit long-range correlations. Here we test the hypothesis that the scaling properties of the dynamics of healthy physiological systems are more stable than those of pathological systems by studying beat-to-beat fluctuations in the human heart rate. We develop techniques based on the Fano factor and Allan factor functions, as well as on detrended fluctuation analysis, for quantifying deviations from uniform power-law scaling in nonstationary time series. By analyzing extremely long data sets of up to N = 10(5) beats for 11 healthy subjects, we find that the fluctuations in the heart rate scale approximately uniformly over several temporal orders of magnitude. By contrast, we find that in data sets of comparable length for 14 subjects with heart disease, the fluctuations grow erratically, indicating a loss of scaling stability.

Diffusion time scales and accretion in the sun

International Nuclear Information System (INIS)

Michaud, G.

1977-01-01

It is thought that surface abundances in the Sun could be due largely to accretion either of comets or grains, and it has been suggested that if surface convection zones were smaller than is usually indicated by model calculations, accretion would be especially important. Unless the zone immediately below the surface convection zone is sufficiently stable for diffusion to be important, other transport processes, such as turbulence and meridional circulation, more efficient than diffusion, will tend to homogenise the Sun. Diffusion is the slowest of the transport processes and will become important when other transport processes become inoperative. Using diffusion theory the minimum mass of the convection zone can be determined in order that transport processes at the bottom of the zone are not to influence abundances in the convection zone. If diffusion time scales are shorter than the life of the star (Sun) diffusion will modify the abundances in the convection zone. The mass in the convection zone for which diffusion time scales are equal to the life of the star on the main sequence then determines the minimum mass in the convection zone that justifies neglect of transport processes at the bottom of the convection zone. It is calculated here that, for the Sun, this mass is between 3 x 10 -3 and 10 -2 solar mass, and a general explosion is derived for the diffusion time scale as a function of the mass of the convection zone. (U.K.)

Advance on the technology of assembly and disassembly of a head frame with four legs and the machine-assembled head frame

Energy Technology Data Exchange (ETDEWEB)

Zhou Youzong; Cao Baozhen [Ministry of Coal Industry (China). Geological Exploration Machinery Factory

1996-12-31

According to the meditation of assembling headframes from upper to lower instead of that from lower to upper, the authors created successfully a new type of machine for assembling and disassembling headframes as well as a type of machine-assembled headframe. The new type of headframe not only has the merits of old type of headframe with four legs, but also can keep people away from dangers of working in high space and save the workers much labour. The new technology has good effect on raising productive efficiency. 2 figs.

Continent-scale global change attribution in European birds - combining annual and decadal time scales

DEFF Research Database (Denmark)

Jørgensen, Peter Søgaard; Böhning-Gaese, Katrin; Thorup, Kasper

2016-01-01

foundation for attributing species responses to global change may be achieved by complementing an attributes-based approach by one estimating the relationship between repeated measures of organismal and environmental changes over short time scales. To assess the benefit of this multiscale perspective, we...... on or in the peak of the breeding season with the largest effect sizes observed in cooler parts of species' climatic ranges. Our results document the potential of combining time scales and integrating both species attributes and environmental variables for global change attribution. We suggest such an approach......Species attributes are commonly used to infer impacts of environmental change on multiyear species trends, e.g. decadal changes in population size. However, by themselves attributes are of limited value in global change attribution since they do not measure the changing environment. A broader...

Time scale of diffusion in molecular and cellular biology

International Nuclear Information System (INIS)

Holcman, D; Schuss, Z

2014-01-01

Diffusion is the driver of critical biological processes in cellular and molecular biology. The diverse temporal scales of cellular function are determined by vastly diverse spatial scales in most biophysical processes. The latter are due, among others, to small binding sites inside or on the cell membrane or to narrow passages between large cellular compartments. The great disparity in scales is at the root of the difficulty in quantifying cell function from molecular dynamics and from simulations. The coarse-grained time scale of cellular function is determined from molecular diffusion by the mean first passage time of molecular Brownian motion to a small targets or through narrow passages. The narrow escape theory (NET) concerns this issue. The NET is ubiquitous in molecular and cellular biology and is manifested, among others, in chemical reactions, in the calculation of the effective diffusion coefficient of receptors diffusing on a neuronal cell membrane strewn with obstacles, in the quantification of the early steps of viral trafficking, in the regulation of diffusion between the mother and daughter cells during cell division, and many other cases. Brownian trajectories can represent the motion of a molecule, a protein, an ion in solution, a receptor in a cell or on its membrane, and many other biochemical processes. The small target can represent a binding site or an ionic channel, a hidden active site embedded in a complex protein structure, a receptor for a neurotransmitter on the membrane of a neuron, and so on. The mean time to attach to a receptor or activator determines diffusion fluxes that are key regulators of cell function. This review describes physical models of various subcellular microdomains, in which the NET coarse-grains the molecular scale to a higher cellular-level, thus clarifying the role of cell geometry in determining subcellular function. (topical review)

Time scale of diffusion in molecular and cellular biology

Science.gov (United States)

Holcman, D.; Schuss, Z.

2014-05-01

Diffusion is the driver of critical biological processes in cellular and molecular biology. The diverse temporal scales of cellular function are determined by vastly diverse spatial scales in most biophysical processes. The latter are due, among others, to small binding sites inside or on the cell membrane or to narrow passages between large cellular compartments. The great disparity in scales is at the root of the difficulty in quantifying cell function from molecular dynamics and from simulations. The coarse-grained time scale of cellular function is determined from molecular diffusion by the mean first passage time of molecular Brownian motion to a small targets or through narrow passages. The narrow escape theory (NET) concerns this issue. The NET is ubiquitous in molecular and cellular biology and is manifested, among others, in chemical reactions, in the calculation of the effective diffusion coefficient of receptors diffusing on a neuronal cell membrane strewn with obstacles, in the quantification of the early steps of viral trafficking, in the regulation of diffusion between the mother and daughter cells during cell division, and many other cases. Brownian trajectories can represent the motion of a molecule, a protein, an ion in solution, a receptor in a cell or on its membrane, and many other biochemical processes. The small target can represent a binding site or an ionic channel, a hidden active site embedded in a complex protein structure, a receptor for a neurotransmitter on the membrane of a neuron, and so on. The mean time to attach to a receptor or activator determines diffusion fluxes that are key regulators of cell function. This review describes physical models of various subcellular microdomains, in which the NET coarse-grains the molecular scale to a higher cellular-level, thus clarifying the role of cell geometry in determining subcellular function.

Decoding the Mobility and Time Scales of Protein Loops.

Science.gov (United States)

Gu, Yina; Li, Da-Wei; Brüschweiler, Rafael

2015-03-10

The flexible nature of protein loops and the time scales of their dynamics are critical for many biologically important events at the molecular level, such as protein interaction and recognition processes. In order to obtain a predictive understanding of the dynamic properties of loops, 500 ns molecular dynamics (MD) computer simulations of 38 different proteins were performed and validated using NMR chemical shifts. A total of 169 loops were analyzed and classified into three types, namely fast loops with correlation times Web server (http://spin.ccic.ohio-state.edu/index.php/loop). The results demonstrate that loop dynamics with their time scales can be predicted rapidly with reasonable accuracy, which will allow the screening of average protein structures to help better understand the various roles loops can play in the context of protein-protein interactions and binding.

Structure and dating errors in the geologic time scale and periodicity in mass extinctions

Science.gov (United States)

Stothers, Richard B.

1989-01-01

Structure in the geologic time scale reflects a partly paleontological origin. As a result, ages of Cenozoic and Mesozoic stage boundaries exhibit a weak 28-Myr periodicity that is similar to the strong 26-Myr periodicity detected in mass extinctions of marine life by Raup and Sepkoski. Radiometric dating errors in the geologic time scale, to which the mass extinctions are stratigraphically tied, do not necessarily lessen the likelihood of a significant periodicity in mass extinctions, but do spread the acceptable values of the period over the range 25-27 Myr for the Harland et al. time scale or 25-30 Myr for the DNAG time scale. If the Odin time scale is adopted, acceptable periods fall between 24 and 33 Myr, but are not robust against dating errors. Some indirect evidence from independently-dated flood-basalt volcanic horizons tends to favor the Odin time scale.

Analysis of the stress-deformed condition of the disassembly parabolic antenna

Science.gov (United States)

Odinets, M. N.; Kaygorodtseva, N. V.; Krysova, I. V.

2018-01-01

Active development of satellite communications and computer-aided design systems raises the problem of designing parabolic antennas on a new round of development. The aim of the work was to investigate the influence of the design of the mirror of a parabolic antenna on its endurance under wind load. The research task was an automated analysis of the stress-deformed condition of various designs of computer models of a paraboloid mirror (segmented or holistic) at modeling the exploitation conditions. The peculiarity of the research was that the assembly model of the antenna’s mirror was subjected to rigid connections on the contacting surfaces of the segments and only then the finite element grid was generated. The analysis showed the advantage of the design of the demountable antenna, which consists of cyclic segments, in front of the construction of the holistic antenna. Calculation of the stress-deformed condition of the antennas allows us to conclude that dividing the design of the antenna’s mirror on parabolic and cyclic segments increases it strength and rigidity. In the future, this can be used to minimize the mass of antenna and the dimensions of the disassembled antenna. The presented way of modeling a mirror of a parabolic antenna using to the method of the finite-element analysis can be used in the production of antennas.

REAL-TIME VIDEO SCALING BASED ON CONVOLUTION NEURAL NETWORK ARCHITECTURE

OpenAIRE

S Safinaz; A V Ravi Kumar

2017-01-01

In recent years, video super resolution techniques becomes mandatory requirements to get high resolution videos. Many super resolution techniques researched but still video super resolution or scaling is a vital challenge. In this paper, we have presented a real-time video scaling based on convolution neural network architecture to eliminate the blurriness in the images and video frames and to provide better reconstruction quality while scaling of large datasets from lower resolution frames t...

Authorized Limits for the Release of a 25 Ton Locomotive, Serial Number 21547, at the Area 25 Engine Maintenance, Assembly, and Disassembly Facility, Nevada Test Site, Nevada

International Nuclear Information System (INIS)

Gwin, Jeremy; Frenette, Douglas

2010-01-01

This document contains process knowledge and radiological data and analysis to support approval for release of the 25-ton locomotive, Serial Number 21547, at the Area 25 Engine Maintenance, Assembly, and Disassembly (EMAD) Facility, located on the Nevada Test Site (NTS). The 25-ton locomotive is a small, one-of-a-kind locomotive used to move railcars in support of the Nuclear Engine for Rocket Vehicle Application project. This locomotive was identified as having significant historical value by the Nevada State Railroad Museum in Boulder City, Nevada, where it will be used as a display piece. A substantial effort to characterize the radiological conditions of the locomotive was undertaken by the NTS Management and Operations Contractor, National Security Technologies, LLC (NSTec). During this characterization process, seven small areas on the locomotive had contamination levels that exceeded the NTS release criteria (limits consistent with U.S. Department of Energy (DOE) Order DOE O 5400.5, 'Radiation Protection of the Public and the Environment'). The decision was made to perform radiological decontamination of these known accessible impacted areas to further the release process. On February 9, 2010, NSTec personnel completed decontamination of these seven areas to within the NTS release criteria. Although all accessible areas of the locomotive had been successfully decontaminated to within NTS release criteria, it was plausible that inaccessible areas of the locomotive (i.e., those areas on the locomotive where it was not possible to perform radiological surveys) could potentially have contamination above unrestricted release limits. To access the majority of these inaccessible areas, the locomotive would have to be disassembled. A complete disassembly for a full radiological survey could have permanently destroyed parts and would have ruined the historical value of the locomotive. Complete disassembly would also add an unreasonable financial burden for the

Nucleolus disassembly in mitosis and apoptosis: dynamic redistribution of phosphorylated-c-Myc, fibrillarin and Ki-67

Directory of Open Access Journals (Sweden)

C Soldani

2009-06-01

Full Text Available The nucleolus may undergo disassembly either reversibly during mitosis, or irreversibly in apoptosis, thus allowing the redistribution of the nucleolar proteins.We investigated here by immunocytochemistry the fate of three representative proteins, namely phosphorylated c-Myc, fibrillarin and Ki-67, and found that they behave independently in both processes: they relocate in distinct compartments during mitosis, whereas during apoptosis they may either be cleaved (Ki-67 or be extruded into the cytoplasm with a different kinetics and following an ordered, non chaotic program. The separation of these nucleolar proteins which occurs in early apoptotic nuclei continues also in the cytoplasm, and culminates in the final formation of apoptotic blebs containing different nucleolar proteins: this evidence confirms that the apoptotic bodies may be variable in size, content and surface reactivity, and include heterogeneous aggregates of nuclear proteins and/or nucleic acids.

Cognitive componets of speech at different time scales

DEFF Research Database (Denmark)

Feng, Ling; Hansen, Lars Kai

2007-01-01

Cognitive component analysis (COCA) is defined as unsupervised grouping of data leading to a group structure well aligned with that resulting from human cognitive activity. We focus here on speech at different time scales looking for possible hidden ‘cognitive structure’. Statistical regularities...

Time-Scale and Time-Frequency Analyses of Irregularly Sampled Astronomical Time Series

Directory of Open Access Journals (Sweden)

S. Roques

2005-09-01

Full Text Available We evaluate the quality of spectral restoration in the case of irregular sampled signals in astronomy. We study in details a time-scale method leading to a global wavelet spectrum comparable to the Fourier period, and a time-frequency matching pursuit allowing us to identify the frequencies and to control the error propagation. In both cases, the signals are first resampled with a linear interpolation. Both results are compared with those obtained using Lomb's periodogram and using the weighted waveletZ-transform developed in astronomy for unevenly sampled variable stars observations. These approaches are applied to simulations and to light variations of four variable stars. This leads to the conclusion that the matching pursuit is more efficient for recovering the spectral contents of a pulsating star, even with a preliminary resampling. In particular, the results are almost independent of the quality of the initial irregular sampling.

Multiple time scales in modeling the incidence of infections acquired in intensive care units

Directory of Open Access Journals (Sweden)

Martin Wolkewitz

2016-09-01

Full Text Available Abstract Background When patients are admitted to an intensive care unit (ICU their risk of getting an infection will be highly depend on the length of stay at-risk in the ICU. In addition, risk of infection is likely to vary over calendar time as a result of fluctuations in the prevalence of the pathogen on the ward. Hence risk of infection is expected to depend on two time scales (time in ICU and calendar time as well as competing events (discharge or death and their spatial location. The purpose of this paper is to develop and apply appropriate statistical models for the risk of ICU-acquired infection accounting for multiple time scales, competing risks and the spatial clustering of the data. Methods A multi-center data base from a Spanish surveillance network was used to study the occurrence of an infection due to Methicillin-resistant Staphylococcus aureus (MRSA. The analysis included 84,843 patient admissions between January 2006 and December 2011 from 81 ICUs. Stratified Cox models were used to study multiple time scales while accounting for spatial clustering of the data (patients within ICUs and for death or discharge as competing events for MRSA infection. Results Both time scales, time in ICU and calendar time, are highly associated with the MRSA hazard rate and cumulative risk. When using only one basic time scale, the interpretation and magnitude of several patient-individual risk factors differed. Risk factors concerning the severity of illness were more pronounced when using only calendar time. These differences disappeared when using both time scales simultaneously. Conclusions The time-dependent dynamics of infections is complex and should be studied with models allowing for multiple time scales. For patient individual risk-factors we recommend stratified Cox regression models for competing events with ICU time as the basic time scale and calendar time as a covariate. The inclusion of calendar time and stratification by ICU

Time-dependent approach to collisional ionization using exterior complex scaling

International Nuclear Information System (INIS)

McCurdy, C. William; Horner, Daniel A.; Rescigno, Thomas N.

2002-01-01

We present a time-dependent formulation of the exterior complex scaling method that has previously been used to treat electron-impact ionization of the hydrogen atom accurately at low energies. The time-dependent approach solves a driven Schroedinger equation, and scales more favorably with the number of electrons than the original formulation. The method is demonstrated in calculations for breakup processes in two dimensions (2D) and three dimensions for systems involving short-range potentials and in 2D for electron-impact ionization in the Temkin-Poet model for electron-hydrogen atom collisions

Human learning: Power laws or multiple characteristic time scales?

Directory of Open Access Journals (Sweden)

Gottfried Mayer-Kress

2006-09-01

Full Text Available The central proposal of A. Newell and Rosenbloom (1981 was that the power law is the ubiquitous law of learning. This proposition is discussed in the context of the key factors that led to the acceptance of the power law as the function of learning. We then outline the principles of an epigenetic landscape framework for considering the role of the characteristic time scales of learning and an approach to system identification of the processes of performance dynamics. In this view, the change of performance over time is the product of a superposition of characteristic exponential time scales that reflect the influence of different processes. This theoretical approach can reproduce the traditional power law of practice – within the experimental resolution of performance data sets - but we hypothesize that this function may prove to be a special and perhaps idealized case of learning.

Evaluation of nuclear facility decommissioning projects. Three Mile Island Unit 2 reactor defueling and disassembly. Summary status report. Volume 3

International Nuclear Information System (INIS)

Doerge, D.H.; Miller, R.L.; Scotti, K.S.

1986-05-01

This document summarizes information relating to the preparations for defueling the Three Mile Island Unit 2 (TMI-2) reactor and disassembly activities being performed concurrently with decontamination of the facility. Data have been collected from activity reports, reactor containment entry records, and other sources and entered in a computerized data sysem which permits extraction/manipulation of specific data which can be used in planning for recovery from a loss of coolant event similar to that experienced at TMI-2 on March 28, 1979. This report contains summaries of man-hours, manpower, and radiation exposures incurred during the period of April 23, 1979 to April 16, 1985, in the completion of activities related to preparation for reactor defueling. Support activities conducted outside of radiation areas are not included within the scope of this report. Computerized reports included in this document are: A chronological summary listing work performed for the period; and summary reports for each major task undertaken in connection with the specific scope of this report. Presented in chronological order for the referenced time period. Manually-assembled table summaries are included for: Labor and exposures by department; and labor and exposures by major activity

Data warehousing technologies for large-scale and right-time data

DEFF Research Database (Denmark)

Xiufeng, Liu

heterogeneous sources into a central data warehouse (DW) by Extract-Transform-Load (ETL) at regular time intervals, e.g., monthly, weekly, or daily. But now, it becomes challenging for large-scale data, and hard to meet the near real-time/right-time business decisions. This thesis considers some...

Off-Policy Reinforcement Learning: Optimal Operational Control for Two-Time-Scale Industrial Processes.

Science.gov (United States)

Li, Jinna; Kiumarsi, Bahare; Chai, Tianyou; Lewis, Frank L; Fan, Jialu

2017-12-01

Industrial flow lines are composed of unit processes operating on a fast time scale and performance measurements known as operational indices measured at a slower time scale. This paper presents a model-free optimal solution to a class of two time-scale industrial processes using off-policy reinforcement learning (RL). First, the lower-layer unit process control loop with a fast sampling period and the upper-layer operational index dynamics at a slow time scale are modeled. Second, a general optimal operational control problem is formulated to optimally prescribe the set-points for the unit industrial process. Then, a zero-sum game off-policy RL algorithm is developed to find the optimal set-points by using data measured in real-time. Finally, a simulation experiment is employed for an industrial flotation process to show the effectiveness of the proposed method.

Fission time-scale from the measurement of pre-scission light ...

Indian Academy of Sciences (India)

and hence can only probe a part of the fission time distribution. .... with the conclusion of recent fission time-scale measurements using the fission probability ... using the statistical model code JOANNE2 suitably modified to include the GDR ...

Time scale controversy: Accurate orbital calibration of the early Paleogene

Science.gov (United States)

Roehl, U.; Westerhold, T.; Laskar, J.

2012-12-01

Timing is crucial to understanding the causes and consequences of events in Earth history. The calibration of geological time relies heavily on the accuracy of radioisotopic and astronomical dating. Uncertainties in the computations of Earth's orbital parameters and in radioisotopic dating have hampered the construction of a reliable astronomically calibrated time scale beyond 40 Ma. Attempts to construct a robust astronomically tuned time scale for the early Paleogene by integrating radioisotopic and astronomical dating are only partially consistent. Here, using the new La2010 and La2011 orbital solutions, we present the first accurate astronomically calibrated time scale for the early Paleogene (47-65 Ma) uniquely based on astronomical tuning and thus independent of the radioisotopic determination of the Fish Canyon standard. Comparison with geological data confirms the stability of the new La2011 solution back to 54 Ma. Subsequent anchoring of floating chronologies to the La2011 solution using the very long eccentricity nodes provides an absolute age of 55.530 ± 0.05 Ma for the onset of the Paleocene/Eocene Thermal Maximum (PETM), 54.850 ± 0.05 Ma for the early Eocene ash -17, and 65.250 ± 0.06 Ma for the K/Pg boundary. The new astrochronology presented here indicates that the intercalibration and synchronization of U/Pb and 40Ar/39Ar radioisotopic geochronology is much more challenging than previously thought.

Multi-Scale Entropy Analysis as a Method for Time-Series Analysis of Climate Data

Directory of Open Access Journals (Sweden)

Heiko Balzter

2015-03-01

Full Text Available Evidence is mounting that the temporal dynamics of the climate system are changing at the same time as the average global temperature is increasing due to multiple climate forcings. A large number of extreme weather events such as prolonged cold spells, heatwaves, droughts and floods have been recorded around the world in the past 10 years. Such changes in the temporal scaling behaviour of climate time-series data can be difficult to detect. While there are easy and direct ways of analysing climate data by calculating the means and variances for different levels of temporal aggregation, these methods can miss more subtle changes in their dynamics. This paper describes multi-scale entropy (MSE analysis as a tool to study climate time-series data and to identify temporal scales of variability and their change over time in climate time-series. MSE estimates the sample entropy of the time-series after coarse-graining at different temporal scales. An application of MSE to Central European, variance-adjusted, mean monthly air temperature anomalies (CRUTEM4v is provided. The results show that the temporal scales of the current climate (1960–2014 are different from the long-term average (1850–1960. For temporal scale factors longer than 12 months, the sample entropy increased markedly compared to the long-term record. Such an increase can be explained by systems theory with greater complexity in the regional temperature data. From 1961 the patterns of monthly air temperatures are less regular at time-scales greater than 12 months than in the earlier time period. This finding suggests that, at these inter-annual time scales, the temperature variability has become less predictable than in the past. It is possible that climate system feedbacks are expressed in altered temporal scales of the European temperature time-series data. A comparison with the variance and Shannon entropy shows that MSE analysis can provide additional information on the

Rough order of magnitude cost estimate for immobilization of 50 MT of plutonium sharing existing facilities at Hanford with pit disassembly and conversion facility: alternative 11

International Nuclear Information System (INIS)

DiSabatino, A.

1998-01-01

The purpose of this Cost Estimate Report is to identify preliminary capital and operating costs for a facility to immobilize 50 metric tons (nominal) of plutonium as a ceramic in an existing facility at Hanford, the Fuels and Materials Examination Facility (FMEF). The Pit Disassembly and Conversion Facility (PDCF), which is being costed in a separate report by LANL, will also be located in the FMEF in this co-location option

Time-scale effects on the gain-loss asymmetry in stock indices

Science.gov (United States)

Sándor, Bulcsú; Simonsen, Ingve; Nagy, Bálint Zsolt; Néda, Zoltán

2016-08-01

The gain-loss asymmetry, observed in the inverse statistics of stock indices is present for logarithmic return levels that are over 2 % , and it is the result of the non-Pearson-type autocorrelations in the index. These non-Pearson-type correlations can be viewed also as functionally dependent daily volatilities, extending for a finite time interval. A generalized time-window shuffling method is used to show the existence of such autocorrelations. Their characteristic time scale proves to be smaller (less than 25 trading days) than what was previously believed. It is also found that this characteristic time scale has decreased with the appearance of program trading in the stock market transactions. Connections with the leverage effect are also established.

The length and time scales of water's glass transitions

Science.gov (United States)

Limmer, David T.

2014-06-01

Using a general model for the equilibrium dynamics of supercooled liquids, I compute from molecular properties the emergent length and time scales that govern the nonequilibrium relaxation behavior of amorphous ice prepared by rapid cooling. Upon cooling, the liquid water falls out of equilibrium whereby the temperature dependence of its relaxation time is predicted to change from super-Arrhenius to Arrhenius. A consequence of this crossover is that the location of the apparent glass transition temperature depends logarithmically on cooling rate. Accompanying vitrification is the emergence of a dynamical length-scale, the size of which depends on the cooling rate and varies between angstroms and tens of nanometers. While this protocol dependence clarifies a number of previous experimental observations for amorphous ice, the arguments are general and can be extended to other glass forming liquids.

The length and time scales of water's glass transitions.

Science.gov (United States)

Limmer, David T

2014-06-07

Using a general model for the equilibrium dynamics of supercooled liquids, I compute from molecular properties the emergent length and time scales that govern the nonequilibrium relaxation behavior of amorphous ice prepared by rapid cooling. Upon cooling, the liquid water falls out of equilibrium whereby the temperature dependence of its relaxation time is predicted to change from super-Arrhenius to Arrhenius. A consequence of this crossover is that the location of the apparent glass transition temperature depends logarithmically on cooling rate. Accompanying vitrification is the emergence of a dynamical length-scale, the size of which depends on the cooling rate and varies between angstroms and tens of nanometers. While this protocol dependence clarifies a number of previous experimental observations for amorphous ice, the arguments are general and can be extended to other glass forming liquids.

A Dynamical System Approach Explaining the Process of Development by Introducing Different Time-scales.

Science.gov (United States)

Hashemi Kamangar, Somayeh Sadat; Moradimanesh, Zahra; Mokhtari, Setareh; Bakouie, Fatemeh

2018-06-11

A developmental process can be described as changes through time within a complex dynamic system. The self-organized changes and emergent behaviour during development can be described and modeled as a dynamical system. We propose a dynamical system approach to answer the main question in human cognitive development i.e. the changes during development happens continuously or in discontinuous stages. Within this approach there is a concept; the size of time scales, which can be used to address the aforementioned question. We introduce a framework, by considering the concept of time-scale, in which "fast" and "slow" is defined by the size of time-scales. According to our suggested model, the overall pattern of development can be seen as one continuous function, with different time-scales in different time intervals.

Fine Scale Baleen Whale Behavior Observed Via Tagging Over Daily Time Scales

Science.gov (United States)

2014-09-30

system to do a comparison between the two. While at Wildlife Computers, I also asked for and they kindly provided a small change in how their MK10...cetacean behavior at intermediate daily time scales. Recent efforts to assess the impacts of sound on marine mammals and to estimate foraging ...efficiency have called for the need to measure daily activity budgets to quantify how much of each day an individual devotes to foraging , resting

Atomistic simulations of graphite etching at realistic time scales.

Science.gov (United States)

Aussems, D U B; Bal, K M; Morgan, T W; van de Sanden, M C M; Neyts, E C

2017-10-01

Hydrogen-graphite interactions are relevant to a wide variety of applications, ranging from astrophysics to fusion devices and nano-electronics. In order to shed light on these interactions, atomistic simulation using Molecular Dynamics (MD) has been shown to be an invaluable tool. It suffers, however, from severe time-scale limitations. In this work we apply the recently developed Collective Variable-Driven Hyperdynamics (CVHD) method to hydrogen etching of graphite for varying inter-impact times up to a realistic value of 1 ms, which corresponds to a flux of ∼10 20 m -2 s -1 . The results show that the erosion yield, hydrogen surface coverage and species distribution are significantly affected by the time between impacts. This can be explained by the higher probability of C-C bond breaking due to the prolonged exposure to thermal stress and the subsequent transition from ion- to thermal-induced etching. This latter regime of thermal-induced etching - chemical erosion - is here accessed for the first time using atomistic simulations. In conclusion, this study demonstrates that accounting for long time-scales significantly affects ion bombardment simulations and should not be neglected in a wide range of conditions, in contrast to what is typically assumed.

EDITORIAL: Special issue on time scale algorithms

Science.gov (United States)

Matsakis, Demetrios; Tavella, Patrizia

2008-12-01

This special issue of Metrologia presents selected papers from the Fifth International Time Scale Algorithm Symposium (VITSAS), including some of the tutorials presented on the first day. The symposium was attended by 76 persons, from every continent except Antarctica, by students as well as senior scientists, and hosted by the Real Instituto y Observatorio de la Armada (ROA) in San Fernando, Spain, whose staff further enhanced their nation's high reputation for hospitality. Although a timescale can be simply defined as a weighted average of clocks, whose purpose is to measure time better than any individual clock, timescale theory has long been and continues to be a vibrant field of research that has both followed and helped to create advances in the art of timekeeping. There is no perfect timescale algorithm, because every one embodies a compromise involving user needs. Some users wish to generate a constant frequency, perhaps not necessarily one that is well-defined with respect to the definition of a second. Other users might want a clock which is as close to UTC or a particular reference clock as possible, or perhaps wish to minimize the maximum variation from that standard. In contrast to the steered timescales that would be required by those users, other users may need free-running timescales, which are independent of external information. While no algorithm can meet all these needs, every algorithm can benefit from some form of tuning. The optimal tuning, and even the optimal algorithm, can depend on the noise characteristics of the frequency standards, or of their comparison systems, the most precise and accurate of which are currently Two Way Satellite Time and Frequency Transfer (TWSTFT) and GPS carrier phase time transfer. The interest in time scale algorithms and its associated statistical methodology began around 40 years ago when the Allan variance appeared and when the metrological institutions started realizing ensemble atomic time using more than

NM-Scale Anatomy of an Entire Stardust Carrot Track

Science.gov (United States)

Nakamura-Messenger, K.; Keller, L. P.; Clemett, S. J.; Messenger, S.

2009-01-01

Comet Wild-2 samples collected by NASA s Stardust mission are extremely complex, heterogeneous, and have experienced wide ranges of alteration during the capture process. There are two major types of track morphologies: "carrot" and "bulbous," that reflect different structural/compositional properties of the impactors. Carrot type tracks are typically produced by compact or single mineral grains which survive essentially intact as a single large terminal particle. Bulbous tracks are likely produced by fine-grained or organic-rich impactors [1]. Owing to their challenging nature and especially high value of Stardust samples, we have invested considerable effort in developing both sample preparation and analytical techniques tailored for Stardust sample analyses. Our report focuses on our systematic disassembly and coordinated analysis of Stardust carrot track #112 from the mm to nm-scale.

REAL-TIME VIDEO SCALING BASED ON CONVOLUTION NEURAL NETWORK ARCHITECTURE

Directory of Open Access Journals (Sweden)

S Safinaz

2017-08-01

Full Text Available In recent years, video super resolution techniques becomes mandatory requirements to get high resolution videos. Many super resolution techniques researched but still video super resolution or scaling is a vital challenge. In this paper, we have presented a real-time video scaling based on convolution neural network architecture to eliminate the blurriness in the images and video frames and to provide better reconstruction quality while scaling of large datasets from lower resolution frames to high resolution frames. We compare our outcomes with multiple exiting algorithms. Our extensive results of proposed technique RemCNN (Reconstruction error minimization Convolution Neural Network shows that our model outperforms the existing technologies such as bicubic, bilinear, MCResNet and provide better reconstructed motioning images and video frames. The experimental results shows that our average PSNR result is 47.80474 considering upscale-2, 41.70209 for upscale-3 and 36.24503 for upscale-4 for Myanmar dataset which is very high in contrast to other existing techniques. This results proves our proposed model real-time video scaling based on convolution neural network architecture’s high efficiency and better performance.

Team training using full-scale reactor coolant pump seal mock-ups

International Nuclear Information System (INIS)

McDonald, T.J.; Hamill, R.W.

1987-01-01

The use of full-scale reactor coolant pump (RCP) seal mock-ups has greatly enhanced Northeast Utilities' ability to effectively utilize the team training approach to technical training. With the advent of the Institute of Nuclear Power Operations accreditation come a new emphasis and standards for the integrated training of plant engineering personnel, maintenance mechanics, quality control personnel, and health physics personnel. The results of purchasing full-scale RCP mock-ups to pilot the concept of team training have far exceeded expectations and cost-limiting factors. The initial training program analysis identified RCP seal maintenance as a task that required training for maintenance department personnel. Due to radiation exposure considerations and the unavailability of actual plant equipment for training purposes, the decision was made to procure a mock-up of an RCP seal assembly and housing. This mock-up was designed to facilitate seal cartridge removal, disassembly, assembly, and installation, duplicating all internal components of the seal cartridge and housing area in exact detail

A multiple-time-scale approach to the control of ITBs on JET

International Nuclear Information System (INIS)

Laborde, L.; Mazon, D.; Moreau, D.; Moreau, D.; Ariola, M.; Cordoliani, V.; Tala, T.

2005-01-01

The simultaneous real-time control of the current and temperature gradient profiles could lead to the steady state sustainment of an internal transport barrier (ITB) and so to a stationary optimized plasma regime. Recent experiments in JET have demonstrated significant progress in achieving such a control: different current and temperature gradient target profiles have been reached and sustained for several seconds using a controller based on a static linear model. It's worth noting that the inverse safety factor profile evolves on a slow time scale (resistive time) while the normalized electron temperature gradient reacts on a faster one (confinement time). Moreover these experiments have shown that the controller was sensitive to rapid plasma events such as transient ITBs during the safety factor profile evolution or MHD instabilities which modify the pressure profiles on the confinement time scale. In order to take into account the different dynamics of the controlled profiles and to better react to rapid plasma events the control technique is being improved by using a multiple-time-scale approximation. The paper describes the theoretical analysis and closed-loop simulations using a control algorithm based on two-time-scale state-space model. These closed-loop simulations using the full dynamic but linear model used for the controller design to simulate the plasma response have demonstrated that this new controller allows the normalized electron temperature gradient target profile to be reached faster than the one used in previous experiments. (A.C.)

A multiple-time-scale approach to the control of ITBs on JET

Energy Technology Data Exchange (ETDEWEB)

Laborde, L.; Mazon, D.; Moreau, D. [EURATOM-CEA Association (DSM-DRFC), CEA Cadarache, 13 - Saint Paul lez Durance (France); Moreau, D. [Culham Science Centre, EFDA-JET, Abingdon, OX (United Kingdom); Ariola, M. [EURATOM/ENEA/CREATE Association, Univ. Napoli Federico II, Napoli (Italy); Cordoliani, V. [Ecole Polytechnique, 91 - Palaiseau (France); Tala, T. [EURATOM-Tekes Association, VTT Processes (Finland)

2005-07-01

The simultaneous real-time control of the current and temperature gradient profiles could lead to the steady state sustainment of an internal transport barrier (ITB) and so to a stationary optimized plasma regime. Recent experiments in JET have demonstrated significant progress in achieving such a control: different current and temperature gradient target profiles have been reached and sustained for several seconds using a controller based on a static linear model. It's worth noting that the inverse safety factor profile evolves on a slow time scale (resistive time) while the normalized electron temperature gradient reacts on a faster one (confinement time). Moreover these experiments have shown that the controller was sensitive to rapid plasma events such as transient ITBs during the safety factor profile evolution or MHD instabilities which modify the pressure profiles on the confinement time scale. In order to take into account the different dynamics of the controlled profiles and to better react to rapid plasma events the control technique is being improved by using a multiple-time-scale approximation. The paper describes the theoretical analysis and closed-loop simulations using a control algorithm based on two-time-scale state-space model. These closed-loop simulations using the full dynamic but linear model used for the controller design to simulate the plasma response have demonstrated that this new controller allows the normalized electron temperature gradient target profile to be reached faster than the one used in previous experiments. (A.C.)

Time-scale invariances in preseismic electromagnetic radiation, magnetization and damage evolution of rocks

Directory of Open Access Journals (Sweden)

Y. Kawada

2007-10-01

Full Text Available We investigate the time-scale invariant changes in electromagnetic and mechanical energy releases prior to a rock failure or a large earthquake. The energy release processes are caused by damage evolutions such as crack propagation, motion of charged dislocation, area-enlargement of sheared asperities and repetitive creep-rate changes. Damage mechanics can be used to represent the time-scale invariant evolutions of both brittle and plastic damages. Irreversible thermodynamics applied to the damage mechanics reveals that the damage evolution produces the variations in charge, dipole and electromagnetic signals in addition to mechanical energy release, and yields the time-scale invariant patterns of Benioff electromagnetic radiation and cumulative Benioff strain-release. The irreversible thermodynamic framework of damage mechanics is also applicable to the seismo-magnetic effect, and the time-scale invariance is recognized in the remanent magnetization change associated with damage evolution prior to a rock failure.

A hierarchy of time-scales and the brain.

Science.gov (United States)

Kiebel, Stefan J; Daunizeau, Jean; Friston, Karl J

2008-11-01

In this paper, we suggest that cortical anatomy recapitulates the temporal hierarchy that is inherent in the dynamics of environmental states. Many aspects of brain function can be understood in terms of a hierarchy of temporal scales at which representations of the environment evolve. The lowest level of this hierarchy corresponds to fast fluctuations associated with sensory processing, whereas the highest levels encode slow contextual changes in the environment, under which faster representations unfold. First, we describe a mathematical model that exploits the temporal structure of fast sensory input to track the slower trajectories of their underlying causes. This model of sensory encoding or perceptual inference establishes a proof of concept that slowly changing neuronal states can encode the paths or trajectories of faster sensory states. We then review empirical evidence that suggests that a temporal hierarchy is recapitulated in the macroscopic organization of the cortex. This anatomic-temporal hierarchy provides a comprehensive framework for understanding cortical function: the specific time-scale that engages a cortical area can be inferred by its location along a rostro-caudal gradient, which reflects the anatomical distance from primary sensory areas. This is most evident in the prefrontal cortex, where complex functions can be explained as operations on representations of the environment that change slowly. The framework provides predictions about, and principled constraints on, cortical structure-function relationships, which can be tested by manipulating the time-scales of sensory input.

A hierarchy of time-scales and the brain.

Directory of Open Access Journals (Sweden)

Stefan J Kiebel

2008-11-01

Full Text Available In this paper, we suggest that cortical anatomy recapitulates the temporal hierarchy that is inherent in the dynamics of environmental states. Many aspects of brain function can be understood in terms of a hierarchy of temporal scales at which representations of the environment evolve. The lowest level of this hierarchy corresponds to fast fluctuations associated with sensory processing, whereas the highest levels encode slow contextual changes in the environment, under which faster representations unfold. First, we describe a mathematical model that exploits the temporal structure of fast sensory input to track the slower trajectories of their underlying causes. This model of sensory encoding or perceptual inference establishes a proof of concept that slowly changing neuronal states can encode the paths or trajectories of faster sensory states. We then review empirical evidence that suggests that a temporal hierarchy is recapitulated in the macroscopic organization of the cortex. This anatomic-temporal hierarchy provides a comprehensive framework for understanding cortical function: the specific time-scale that engages a cortical area can be inferred by its location along a rostro-caudal gradient, which reflects the anatomical distance from primary sensory areas. This is most evident in the prefrontal cortex, where complex functions can be explained as operations on representations of the environment that change slowly. The framework provides predictions about, and principled constraints on, cortical structure-function relationships, which can be tested by manipulating the time-scales of sensory input.

A Systematic Multi-Time Scale Solution for Regional Power Grid Operation

Science.gov (United States)

Zhu, W. J.; Liu, Z. G.; Cheng, T.; Hu, B. Q.; Liu, X. Z.; Zhou, Y. F.

2017-10-01

Many aspects need to be taken into consideration in a regional grid while making schedule plans. In this paper, a systematic multi-time scale solution for regional power grid operation considering large scale renewable energy integration and Ultra High Voltage (UHV) power transmission is proposed. In the time scale aspect, we discuss the problem from month, week, day-ahead, within-day to day-behind, and the system also contains multiple generator types including thermal units, hydro-plants, wind turbines and pumped storage stations. The 9 subsystems of the scheduling system are described, and their functions and relationships are elaborated. The proposed system has been constructed in a provincial power grid in Central China, and the operation results further verified the effectiveness of the system.

Current relaxation time scales in toroidal plasmas

International Nuclear Information System (INIS)

Mikkelsen, D.R.

1987-02-01

An approximate normal mode analysis of plasma current diffusion in tokamaks is presented. The work is based on numerical solutions of the current diffusion equation in cylindrical geometry. Eigenvalues and eigenfunctions are shown for a broad range of plasma conductivity profile shapes. Three classes of solutions are considered which correspond to three types of tokamak operation. Convenient approximations to the three lowest eigenvalues in each class are presented and simple formulae for the current relaxation time scales are given

Selenide isotope generator for the Galileo mission. GDS disassembly report

International Nuclear Information System (INIS)

1978-11-01

The GDS-1 was disassembled to determine the cause for the rapid degradation of the output power. Unfortunately, it was not possible to relate the observations to direct causes for the degradation. However, some positive statements can be made which have an impact on the flight program. First, the outgassing and gas management techniques were shown to be adequate to maintain clean conditions within the generator. Second, the non-modular components within the generator including the receptacles on the housing were not affected by the thermal environment during operation of GDS-1. Third, a significant amount of sublimation of the P-legs has occurred during the relatively short life of 2000 + hours as shown by the bullet nosing of the legs and deposits on the cold end hardware. The fact that the generator atmosphere was not 100% xenon may have some bearing on this observation but the statement is still accurate. Fourth, all exposed N-legs display cracks and/or chips. Fifth, a great deal of misalignment of both N and P-legs was seen both visually and with radiographs. Although no definite conclusions can be made concerning the cause for the rapid degradation of performance, several of the observed conditions within the module could possibly contribute to that fact. They are: cracks in N-legs (increased resistance); deposits on edges of BeO discs (shorting of thermoelectric circuit); and bullet nosing of P-legs (increased resistance). It remains to be shown if any of these effects or the follower hangup described earlier contributed to the poor performance of GDS-1 or if another effect as yet unknown was the important factor

Impact of sequential disorder on the scaling behavior of airplane boarding time

Science.gov (United States)

Baek, Yongjoo; Ha, Meesoon; Jeong, Hawoong

2013-05-01

Airplane boarding process is an example where disorder properties of the system are relevant to the emergence of universality classes. Based on a simple model, we present a systematic analysis of finite-size effects in boarding time, and propose a comprehensive view of the role of sequential disorder in the scaling behavior of boarding time against the plane size. Using numerical simulations and mathematical arguments, we find how the scaling behavior depends on the number of seat columns and the range of sequential disorder. Our results show that new scaling exponents can arise as disorder is localized to varying extents.

Global Exponential Stability of Delayed Cohen-Grossberg BAM Neural Networks with Impulses on Time Scales

Directory of Open Access Journals (Sweden)

Yongkun Li

2009-01-01

Full Text Available Based on the theory of calculus on time scales, the homeomorphism theory, Lyapunov functional method, and some analysis techniques, sufficient conditions are obtained for the existence, uniqueness, and global exponential stability of the equilibrium point of Cohen-Grossberg bidirectional associative memory (BAM neural networks with distributed delays and impulses on time scales. This is the first time applying the time-scale calculus theory to unify the discrete-time and continuous-time Cohen-Grossberg BAM neural network with impulses under the same framework.

Doubly stochastic Poisson process models for precipitation at fine time-scales

Science.gov (United States)

Ramesh, Nadarajah I.; Onof, Christian; Xie, Dichao

2012-09-01

This paper considers a class of stochastic point process models, based on doubly stochastic Poisson processes, in the modelling of rainfall. We examine the application of this class of models, a neglected alternative to the widely-known Poisson cluster models, in the analysis of fine time-scale rainfall intensity. These models are mainly used to analyse tipping-bucket raingauge data from a single site but an extension to multiple sites is illustrated which reveals the potential of this class of models to study the temporal and spatial variability of precipitation at fine time-scales.

Dynamics analysis of the fast-slow hydro-turbine governing system with different time-scale coupling

Science.gov (United States)

Zhang, Hao; Chen, Diyi; Wu, Changzhi; Wang, Xiangyu

2018-01-01

Multi-time scales modeling of hydro-turbine governing system is crucial in precise modeling of hydropower plant and provides support for the stability analysis of the system. Considering the inertia and response time of the hydraulic servo system, the hydro-turbine governing system is transformed into the fast-slow hydro-turbine governing system. The effects of the time-scale on the dynamical behavior of the system are analyzed and the fast-slow dynamical behaviors of the system are investigated with different time-scale. Furthermore, the theoretical analysis of the stable regions is presented. The influences of the time-scale on the stable region are analyzed by simulation. The simulation results prove the correctness of the theoretical analysis. More importantly, the methods and results of this paper provide a perspective to multi-time scales modeling of hydro-turbine governing system and contribute to the optimization analysis and control of the system.

Disassembly of Bacterial Biofilms by the Self-Assembled Glycolipids Derived from Renewable Resources.

Science.gov (United States)

Prasad, Yadavali Siva; Miryala, Sandeep; Lalitha, Krishnamoorthy; Ranjitha, K; Barbhaiwala, Shehnaz; Sridharan, Vellaisamy; Maheswari, C Uma; Srinandan, C S; Nagarajan, Subbiah

2017-11-22

More than 80% of chronic infections of bacteria are caused by biofilms. It is also a long-term survival strategy of the pathogens in a nonhost environment. Several amphiphilic molecules have been used in the past to potentially disrupt biofilms; however, the involvement of multistep synthesis, complicated purification and poor yield still remains a major problem. Herein, we report a facile synthesis of glycolipid based surfactant from renewable feedstocks in good yield. The nature of carbohydrate unit present in glycolipid influence the ring chain tautomerism, which resulted in the existence of either cyclic structure or both cyclic and acyclic structures. Interestingly, these glycolipids self-assemble into gel in highly hydrophobic solvents and vegetable oils, and displayed foam formation in water. The potential application of these self-assembled glycolipids to disrupt preformed biofilm was examined against various pathogens. It was observed that glycolipid 6a disrupts Staphylococcus aureus and Listeria monocytogenes biofilm, while the compound 6c was effective in disassembling uropathogenic E. coli and Salmonella enterica Typhimurium biofilms. Altogether, the supramolecular self-assembled materials, either as gel or as surfactant solution could be potentially used for surface cleansing in hospital environments or the food processing industries to effectively reduce pathogenic biofilms.

Substantiation of the admissable concentration of radionuclides in the utilization of concrete from disassembled reactors

International Nuclear Information System (INIS)

Engovatov, I.A.; Mashkovich, V.P.; Morev, M.N.

1995-01-01

The complete or partial disassembly of the buildings and systems of a modern nuclear power plant results in the formation of hundreds of thousands of tons of wastes. More than 90% of this mass consists of reinforced concrete. Only a small fraction of these materials is contaminated and/or activated up to high level and must be treated as radioactive wastes that must be buried. For this reason, it is helpful to consider a variant of recycling of some of the wastes and secondary utilization of these wastes in different industrial production processes. In this paper, we analyze the concrete that is freed when a nuclear power plant is decommissioned, and in particular, we examine three scenarios: (1) stockpiling and long-term storage of concrete at an industrial site, (2) highway construction, and (3) industrial building construction. Admissable radionuclide concentrations of several isotopes are tabulated for each scenario, and the results provide the basic information for the development of standards for the utilization of the concrete wastes produced during the decommissioning of nuclear power plants

Studies and research concerning BNFP design and construction of a spent-fuel disassembly/encapsulation system

International Nuclear Information System (INIS)

Dabolt, R.J.

1981-04-01

Commercial light water power reactor operation in the United States is developing a cumbersome inventory of spent fuel. Systems for interim storage and handling of this fuel are being developed by the Federal Government and industry. Disassembly and canning of the spent fuel elements is one of these systems. It has the potential to double the storage capacity of a prereprocessing storage facility or to triple the capacity of conventional shipping casks. Prototype equipment and controls required to perform this operation in a dry environment have been primarily designed and fabricated at the Barnwell Nuclear Fuel Plant (BNFP). Ridihalgh, Eggers, and Associates have provided design support and fabrication of the control system. This system is capable of extracting and canning the fuel pins and compacting the nonfuel-bearing components of spent fuel assemblies at processing rates of 10 to 12 assemblies per day. The process also provides the potential for enhanced inspection and assay of spent fuel by reducing the interference encountered from the high gamma fields of the nonfuel bearing hardware

Urban Freight Management with Stochastic Time-Dependent Travel Times and Application to Large-Scale Transportation Networks

Directory of Open Access Journals (Sweden)

Shichao Sun

2015-01-01

Full Text Available This paper addressed the vehicle routing problem (VRP in large-scale urban transportation networks with stochastic time-dependent (STD travel times. The subproblem which is how to find the optimal path connecting any pair of customer nodes in a STD network was solved through a robust approach without requiring the probability distributions of link travel times. Based on that, the proposed STD-VRP model can be converted into solving a normal time-dependent VRP (TD-VRP, and algorithms for such TD-VRPs can also be introduced to obtain the solution. Numerical experiments were conducted to address STD-VRPTW of practical sizes on a real world urban network, demonstrated here on the road network of Shenzhen, China. The stochastic time-dependent link travel times of the network were calibrated by historical floating car data. A route construction algorithm was applied to solve the STD problem in 4 delivery scenarios efficiently. The computational results showed that the proposed STD-VRPTW model can improve the level of customer service by satisfying the time-window constraint under any circumstances. The improvement can be very significant especially for large-scale network delivery tasks with no more increase in cost and environmental impacts.

A hybrid procedure for MSW generation forecasting at multiple time scales in Xiamen City, China

International Nuclear Information System (INIS)

Xu, Lilai; Gao, Peiqing; Cui, Shenghui; Liu, Chun

2013-01-01

Highlights: ► We propose a hybrid model that combines seasonal SARIMA model and grey system theory. ► The model is robust at multiple time scales with the anticipated accuracy. ► At month-scale, the SARIMA model shows good representation for monthly MSW generation. ► At medium-term time scale, grey relational analysis could yield the MSW generation. ► At long-term time scale, GM (1, 1) provides a basic scenario of MSW generation. - Abstract: Accurate forecasting of municipal solid waste (MSW) generation is crucial and fundamental for the planning, operation and optimization of any MSW management system. Comprehensive information on waste generation for month-scale, medium-term and long-term time scales is especially needed, considering the necessity of MSW management upgrade facing many developing countries. Several existing models are available but of little use in forecasting MSW generation at multiple time scales. The goal of this study is to propose a hybrid model that combines the seasonal autoregressive integrated moving average (SARIMA) model and grey system theory to forecast MSW generation at multiple time scales without needing to consider other variables such as demographics and socioeconomic factors. To demonstrate its applicability, a case study of Xiamen City, China was performed. Results show that the model is robust enough to fit and forecast seasonal and annual dynamics of MSW generation at month-scale, medium- and long-term time scales with the desired accuracy. In the month-scale, MSW generation in Xiamen City will peak at 132.2 thousand tonnes in July 2015 – 1.5 times the volume in July 2010. In the medium term, annual MSW generation will increase to 1518.1 thousand tonnes by 2015 at an average growth rate of 10%. In the long term, a large volume of MSW will be output annually and will increase to 2486.3 thousand tonnes by 2020 – 2.5 times the value for 2010. The hybrid model proposed in this paper can enable decision makers to

A hybrid procedure for MSW generation forecasting at multiple time scales in Xiamen City, China

Energy Technology Data Exchange (ETDEWEB)

Xu, Lilai, E-mail: llxu@iue.ac.cn [Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021 (China); Xiamen Key Lab of Urban Metabolism, Xiamen 361021 (China); Gao, Peiqing, E-mail: peiqing15@yahoo.com.cn [Xiamen City Appearance and Environmental Sanitation Management Office, 51 Hexiangxi Road, Xiamen 361004 (China); Cui, Shenghui, E-mail: shcui@iue.ac.cn [Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021 (China); Xiamen Key Lab of Urban Metabolism, Xiamen 361021 (China); Liu, Chun, E-mail: xmhwlc@yahoo.com.cn [Xiamen City Appearance and Environmental Sanitation Management Office, 51 Hexiangxi Road, Xiamen 361004 (China)

2013-06-15

Highlights: ► We propose a hybrid model that combines seasonal SARIMA model and grey system theory. ► The model is robust at multiple time scales with the anticipated accuracy. ► At month-scale, the SARIMA model shows good representation for monthly MSW generation. ► At medium-term time scale, grey relational analysis could yield the MSW generation. ► At long-term time scale, GM (1, 1) provides a basic scenario of MSW generation. - Abstract: Accurate forecasting of municipal solid waste (MSW) generation is crucial and fundamental for the planning, operation and optimization of any MSW management system. Comprehensive information on waste generation for month-scale, medium-term and long-term time scales is especially needed, considering the necessity of MSW management upgrade facing many developing countries. Several existing models are available but of little use in forecasting MSW generation at multiple time scales. The goal of this study is to propose a hybrid model that combines the seasonal autoregressive integrated moving average (SARIMA) model and grey system theory to forecast MSW generation at multiple time scales without needing to consider other variables such as demographics and socioeconomic factors. To demonstrate its applicability, a case study of Xiamen City, China was performed. Results show that the model is robust enough to fit and forecast seasonal and annual dynamics of MSW generation at month-scale, medium- and long-term time scales with the desired accuracy. In the month-scale, MSW generation in Xiamen City will peak at 132.2 thousand tonnes in July 2015 – 1.5 times the volume in July 2010. In the medium term, annual MSW generation will increase to 1518.1 thousand tonnes by 2015 at an average growth rate of 10%. In the long term, a large volume of MSW will be output annually and will increase to 2486.3 thousand tonnes by 2020 – 2.5 times the value for 2010. The hybrid model proposed in this paper can enable decision makers to

A multi scale approximation solution for the time dependent Boltzmann-transport equation

International Nuclear Information System (INIS)

Merk, B.

2004-03-01

The basis of all transient simulations for nuclear reactor cores is the reliable calculation of the power production. The local power distribution is generally calculated by solving the space, time, energy and angle dependent neutron transport equation known as Boltzmann equation. The computation of exact solutions of the Boltzmann equation is very time consuming. For practical numerical simulations approximated solutions are usually unavoidable. The objective of this work is development of an effective multi scale approximation solution for the Boltzmann equation. Most of the existing methods are based on separation of space and time. The new suggested method is performed without space-time separation. This effective approximation solution is developed on the basis of an expansion for the time derivative of different approximations to the Boltzmann equation. The method of multiple scale expansion is used for the expansion of the time derivative, because the problem of the stiff time behaviour can't be expressed by standard expansion methods. This multiple scale expansion is used in this work to develop approximation solutions for different approximations of the Boltzmann equation, starting from the expansion of the point kinetics equations. The resulting analytic functions are used for testing the applicability and accuracy of the multiple scale expansion method for an approximation solution with 2 delayed neutron groups. The results are tested versus the exact analytical results for the point kinetics equations. Very good agreement between both solutions is obtained. The validity of the solution with 2 delayed neutron groups to approximate the behaviour of the system with 6 delayed neutron groups is demonstrated in an additional analysis. A strategy for a solution with 4 delayed neutron groups is described. A multiple scale expansion is performed for the space-time dependent diffusion equation for one homogenized cell with 2 delayed neutron groups. The result is

HMC algorithm with multiple time scale integration and mass preconditioning

Science.gov (United States)

Urbach, C.; Jansen, K.; Shindler, A.; Wenger, U.

2006-01-01

We present a variant of the HMC algorithm with mass preconditioning (Hasenbusch acceleration) and multiple time scale integration. We have tested this variant for standard Wilson fermions at β=5.6 and at pion masses ranging from 380 to 680 MeV. We show that in this situation its performance is comparable to the recently proposed HMC variant with domain decomposition as preconditioner. We give an update of the "Berlin Wall" figure, comparing the performance of our variant of the HMC algorithm to other published performance data. Advantages of the HMC algorithm with mass preconditioning and multiple time scale integration are that it is straightforward to implement and can be used in combination with a wide variety of lattice Dirac operators.

Nonlinear MHD dynamics of tokamak plasmas on multiple time scales

International Nuclear Information System (INIS)

Kruger, S.E.; Schnack, D.D.; Brennan, D.P.; Gianakon, T.A.; Sovinec, C.R.

2003-01-01

Two types of numerical, nonlinear simulations using the NIMROD code are presented. In the first simulation, we model the disruption occurring in DIII-D discharge 87009 as an ideal MHD instability driven unstable by neutral-beam heating. The mode grows faster than exponential, but on a time scale that is a hybrid of the heating rate and the ideal MHD growth rate as predicted by analytic theory. The second type of simulations, which occur on a much longer time scale, focus on the seeding of tearing modes by sawteeth. Pressure effects play a role both in the exterior region solutions and in the neoclassical drive terms. The results of both simulations are reviewed and their implications for experimental analysis is discussed. (author)

Fission time-scale in experiments and in multiple initiation model

Energy Technology Data Exchange (ETDEWEB)

Karamian, S. A., E-mail: karamian@nrmail.jinr.ru [Joint Institute for Nuclear Research (Russian Federation)

2011-12-15

Rate of fission for highly-excited nuclei is affected by the viscose character of the systemmotion in deformation coordinates as was reported for very heavy nuclei with Z{sub C} > 90. The long time-scale of fission can be described in a model of 'fission by diffusion' that includes an assumption of the overdamped diabatic motion. The fission-to-spallation ratio at intermediate proton energy could be influenced by the viscosity, as well. Within a novel approach of the present work, the cross examination of the fission probability, time-scales, and pre-fission neutron multiplicities is resulted in the consistent interpretation of a whole set of the observables. Earlier, different aspects could be reproduced in partial simulations without careful coordination.

A Study on Time-Scales Ratio and Turbulent Prandtl Number in Ducts of Industrial Applications

DEFF Research Database (Denmark)

Rokni, Masoud

2006-01-01

is solved using a two-equation heat flux model. The computed results compare satisfactory with the available experimental data. The time-scale ratio R is defined as the ratio between the dynamic time-scale (k/ε) and the scalar time-scale(0.5θθ/εθ). Based on existing DNS data and calculations in this work...... of heat exchangers for various applications area....

Projective synchronization of time-varying delayed neural network with adaptive scaling factors

International Nuclear Information System (INIS)

Ghosh, Dibakar; Banerjee, Santo

2013-01-01

Highlights: • Projective synchronization in coupled delayed neural chaotic systems with modulated delay time is introduced. • An adaptive rule for the scaling factors is introduced. • This scheme is highly applicable in secure communication. -- Abstract: In this work, the projective synchronization between two continuous time delayed neural systems with time varying delay is investigated. A sufficient condition for synchronization for the coupled systems with modulated delay is presented analytically with the help of the Krasovskii–Lyapunov approach. The effect of adaptive scaling factors on synchronization are also studied in details. Numerical simulations verify the effectiveness of the analytic results

On the time-scales of magmatism at island-arc volcanoes.

Science.gov (United States)

Turner, S P

2002-12-15

Precise information on time-scales and rates of change is fundamental to an understanding of natural processes and the development of quantitative physical models in the Earth sciences. U-series isotope studies are revolutionizing this field by providing time information in the range 10(2)-10(4) years, which is similar to that of many modern Earth processes. I review how the application of U-series isotopes has been used to constrain the time-scales of magma formation, ascent and storage beneath island-arc volcanoes. Different elements are distilled-off the subducting plate at different times and in different places. Contributions from subducted sediments to island-arc lava sources appear to occur some 350 kyr to 4 Myr prior to eruption. Fluid release from the subducting oceanic crust into the mantle wedge may be a multi-stage process and occurs over a period ranging from a few hundred kyr to less than one kyr prior to eruption. This implies that dehydration commences prior to the initiation of partial melting within the mantle wedge, which is consistent with recent evidence that the onset of melting is controlled by an isotherm and thus the thermal structure within the wedge. U-Pa disequilibria appear to require a component of decompression melting, possibly due to the development of gravitational instabilities. The preservation of large (226)Ra disequilibria permits only a short period of time between fluid addition and eruption. This requires rapid melt segregation, magma ascent by channelled flow and minimal residence time within the lithosphere. The evolution from basalt to basaltic andesite probably occurs rapidly during ascent or in magma reservoirs inferred from some geophysical data to lie within the lithospheric mantle. The flux across the Moho is broadly andesitic, and some magmas subsequently stall in more shallow crustal-level magma chambers, where they evolve to more differentiated compositions on time-scales of a few thousand years or less.

Development of the Free Time Motivation Scale for Adolescents.

Science.gov (United States)

Baldwin, Cheryl K.; Caldwell, Linda L.

2003-01-01

Developed a self-report measure of adolescent free time motivation based in self-determination theory, using data from 634 seventh graders. The scale measured five forms of motivation (amotivation, external, introjected, identified, and intrinsic motivation). Examination of each of the subscales indicated minimally acceptable levels of fit. The…

Modelling financial markets with agents competing on different time scales and with different amount of information

Science.gov (United States)

Wohlmuth, Johannes; Andersen, Jørgen Vitting

2006-05-01

We use agent-based models to study the competition among investors who use trading strategies with different amount of information and with different time scales. We find that mixing agents that trade on the same time scale but with different amount of information has a stabilizing impact on the large and extreme fluctuations of the market. Traders with the most information are found to be more likely to arbitrage traders who use less information in the decision making. On the other hand, introducing investors who act on two different time scales has a destabilizing effect on the large and extreme price movements, increasing the volatility of the market. Closeness in time scale used in the decision making is found to facilitate the creation of local trends. The larger the overlap in commonly shared information the more the traders in a mixed system with different time scales are found to profit from the presence of traders acting at another time scale than themselves.

Long time scale hard X-ray variability in Seyfert 1 galaxies

Science.gov (United States)

Markowitz, Alex Gary

This dissertation examines the relationship between long-term X-ray variability characteristics, black hole mass, and luminosity of Seyfert 1 Active Galactic Nuclei. High dynamic range power spectral density functions (PSDs) have been constructed for six Seyfert 1 galaxies. These PSDs show "breaks" or characteristic time scales, typically on the order of a few days. There is resemblance to PSDs of lower-mass Galactic X-ray binaries (XRBs), with the ratios of putative black hole masses and variability time scales approximately the same (106--7) between the two classes of objects. The data are consistent with a linear correlation between Seyfert PSD break time scale and black hole mass estimate; the relation extrapolates reasonably well over 6--7 orders of magnitude to XRBs. All of this strengthens the case for a physical similarity between Seyfert galaxies and XRBs. The first six years of RXTE monitoring of Seyfert 1s have been systematically analyzed to probe hard X-ray variability on multiple time scales in a total of 19 Seyfert is in an expansion of the survey of Markowitz & Edelson (2001). Correlations between variability amplitude, luminosity, and black hole mass are explored, the data support the model of PSD movement with black hole mass suggested by the PSD survey. All of the continuum variability results are consistent with relatively more massive black holes hosting larger X-ray emission regions, resulting in 'slower' observed variability. Nearly all sources in the sample exhibit stronger variability towards softer energies, consistent with softening as they brighten. Direct time-resolved spectral fitting has been performed on continuous RXTE monitoring of seven Seyfert is to study long-term spectral variability and Fe Kalpha variability characteristics. The Fe Kalpha line displays a wide range of behavior but varies less strongly than the broadband continuum. Overall, however, there is no strong evidence for correlated variability between the line and

Flow characteristics of a pilot-scale high temperature, short time pasteurizer.

Science.gov (United States)

Tomasula, P M; Kozempel, M F

2004-09-01

In this study, we present a method for determining the fastest moving particle (FMP) and residence time distribution (RTD) in a pilot-scale high temperature, short time (HTST) pasteurizer to ensure that laboratory or pilot-scale HTST apparatus meets the Pasteurized Milk Ordinance standards for pasteurization of milk and can be used for obtaining thermal inactivation data. The overall dimensions of the plate in the pasteurizer were 75 x 115 mm, with a thickness of 0.5 mm and effective diameter of 3.0 mm. The pasteurizer was equipped with nominal 21.5- and 52.2-s hold tubes, and flow capacity was variable from 0 to 20 L/h. Tracer studies were used to determine FMP times and RTD data to establish flow characteristics. Using brine milk as tracer, the FMP time for the short holding section was 18.6 s and for the long holding section was 36 s at 72 degrees C, compared with the nominal times of 21.5 and 52.2 s, respectively. The RTD study indicates that the short hold section was 45% back mixed and 55% plug flow for whole milk at 72 degrees C. The long hold section was 91% plug and 9% back mixed for whole milk at 72 degrees C. This study demonstrates that continuous laboratory and pilot-scale pasteurizers may be used to study inactivation of microorganisms only if the flow conditions in the holding tube are established for comparison with commercial HTST systems.

Theoretical restrictions on longest implicit time scales in Markov state models of biomolecular dynamics

Science.gov (United States)

Sinitskiy, Anton V.; Pande, Vijay S.

2018-01-01

Markov state models (MSMs) have been widely used to analyze computer simulations of various biomolecular systems. They can capture conformational transitions much slower than an average or maximal length of a single molecular dynamics (MD) trajectory from the set of trajectories used to build the MSM. A rule of thumb claiming that the slowest implicit time scale captured by an MSM should be comparable by the order of magnitude to the aggregate duration of all MD trajectories used to build this MSM has been known in the field. However, this rule has never been formally proved. In this work, we present analytical results for the slowest time scale in several types of MSMs, supporting the above rule. We conclude that the slowest implicit time scale equals the product of the aggregate sampling and four factors that quantify: (1) how much statistics on the conformational transitions corresponding to the longest implicit time scale is available, (2) how good the sampling of the destination Markov state is, (3) the gain in statistics from using a sliding window for counting transitions between Markov states, and (4) a bias in the estimate of the implicit time scale arising from finite sampling of the conformational transitions. We demonstrate that in many practically important cases all these four factors are on the order of unity, and we analyze possible scenarios that could lead to their significant deviation from unity. Overall, we provide for the first time analytical results on the slowest time scales captured by MSMs. These results can guide further practical applications of MSMs to biomolecular dynamics and allow for higher computational efficiency of simulations.

Studying time of flight imaging through scattering media across multiple size scales (Conference Presentation)

Science.gov (United States)

Velten, Andreas

2017-05-01

Light scattering is a primary obstacle to optical imaging in a variety of different environments and across many size and time scales. Scattering complicates imaging on large scales when imaging through the atmosphere when imaging from airborne or space borne platforms, through marine fog, or through fog and dust in vehicle navigation, for example in self driving cars. On smaller scales, scattering is the major obstacle when imaging through human tissue in biomedical applications. Despite the large variety of participating materials and size scales, light transport in all these environments is usually described with very similar scattering models that are defined by the same small set of parameters, including scattering and absorption length and phase function. We attempt a study of scattering and methods of imaging through scattering across different scales and media, particularly with respect to the use of time of flight information. We can show that using time of flight, in addition to spatial information, provides distinct advantages in scattering environments. By performing a comparative study of scattering across scales and media, we are able to suggest scale models for scattering environments to aid lab research. We also can transfer knowledge and methodology between different fields.

An alcator-like confinement time scaling law derived from buckingham's PI theorem

International Nuclear Information System (INIS)

Roth, J.R.

1983-01-01

The unsatisfactory state of understanding of particle transport and confinement in tokamaks is well known. The best available theory, neoclassical transport, predicts a confinement time which scales as the square of the magnetic field, and inversely as the number density. Until recently, the best available phenomenological scaling law was the Alcator scaling law. This scaling law has recently been supplanted by the neoAlcator scaling law. Both of these expressions are unsatisfactory, because they not only are unsupported by any physical theory, but also their numerical constants are dimensional, suggesting that additional physical parameters need to be accounted for. A more firmly based scaling law can be derived from Buckingham's pi theorem. We adopt the particle confinement time as the dependent variable (derived dimension), and as independent variables (fundamental dimensions) we use the plasma volume, the average ion charge density, the ion current on the limiter, and the magnetic induction. From Buckingham's pi theorem, we obtain an equation which correctly predicts the absence of magnetic induction dependence, and the direct dependence on the ion density. The dependence on the product of the major radius and the plasma radius is intermediate between the original and neoAlcator scaling laws, and may be consistent with the data if the ion kinetic temperature and limiter area were accounted for

Existence and global exponential stability of periodic solutions for n-dimensional neutral dynamic equations on time scales.

Science.gov (United States)

Li, Bing; Li, Yongkun; Zhang, Xuemei

2016-01-01

In this paper, by using the existence of the exponential dichotomy of linear dynamic equations on time scales and the theory of calculus on time scales, we study the existence and global exponential stability of periodic solutions for a class of n-dimensional neutral dynamic equations on time scales. We also present an example to illustrate the feasibility of our results. The results of this paper are completely new and complementary to the previously known results even in both the case of differential equations (time scale [Formula: see text]) and the case of difference equations (time scale [Formula: see text]).

Stability theory for dynamic equations on time scales

CERN Document Server

Martynyuk, Anatoly A

2016-01-01

This monograph is a first in the world to present three approaches for stability analysis of solutions of dynamic equations. The first approach is based on the application of dynamic integral inequalities and the fundamental matrix of solutions of linear approximation of dynamic equations. The second is based on the generalization of the direct Lyapunovs method for equations on time scales, using scalar, vector and matrix-valued auxiliary functions. The third approach is the application of auxiliary functions (scalar, vector, or matrix-valued ones) in combination with differential dynamic inequalities. This is an alternative comparison method, developed for time continuous and time discrete systems. In recent decades, automatic control theory in the study of air- and spacecraft dynamics and in other areas of modern applied mathematics has encountered problems in the analysis of the behavior of solutions of time continuous-discrete linear and/or nonlinear equations of perturbed motion. In the book “Men of Ma...

The multiple time scales of sleep dynamics as a challenge for modelling the sleeping brain.

Science.gov (United States)

Olbrich, Eckehard; Claussen, Jens Christian; Achermann, Peter

2011-10-13

A particular property of the sleeping brain is that it exhibits dynamics on very different time scales ranging from the typical sleep oscillations such as sleep spindles and slow waves that can be observed in electroencephalogram (EEG) segments of several seconds duration over the transitions between the different sleep stages on a time scale of minutes to the dynamical processes involved in sleep regulation with typical time constants in the range of hours. There is an increasing body of work on mathematical and computational models addressing these different dynamics, however, usually considering only processes on a single time scale. In this paper, we review and present a new analysis of the dynamics of human sleep EEG at the different time scales and relate the findings to recent modelling efforts pointing out both the achievements and remaining challenges.

Double Scaling in the Relaxation Time in the β -Fermi-Pasta-Ulam-Tsingou Model

Science.gov (United States)

Lvov, Yuri V.; Onorato, Miguel

2018-04-01

We consider the original β -Fermi-Pasta-Ulam-Tsingou system; numerical simulations and theoretical arguments suggest that, for a finite number of masses, a statistical equilibrium state is reached independently of the initial energy of the system. Using ensemble averages over initial conditions characterized by different Fourier random phases, we numerically estimate the time scale of equipartition and we find that for very small nonlinearity it matches the prediction based on exact wave-wave resonant interaction theory. We derive a simple formula for the nonlinear frequency broadening and show that when the phenomenon of overlap of frequencies takes place, a different scaling for the thermalization time scale is observed. Our result supports the idea that the Chirikov overlap criterion identifies a transition region between two different relaxation time scalings.

An extended Halanay inequality of integral type on time scales

Directory of Open Access Journals (Sweden)

Boqun Ou

2015-07-01

Full Text Available In this paper, we obtain a Halanay-type inequality of integral type on time scales which improves and extends some earlier results for both the continuous and discrete cases. Several illustrative examples are also given.

New findings on the onset of thermal disassembly in spallation reactions

International Nuclear Information System (INIS)

Napolitani, P.

2004-09-01

Thermal multifragmentation is the process of multi body disassembly of a hot nucleus when the excitation is almost purely thermal i.e. dynamical effects like compression (characteristic of ion-ion collisions at Fermi energy) are negligible. Suited reactions are proton induced collision or ion-ion abrasion at relativistic incident energy. Thus we measured four systems at FRS (Fragment separator, GSI, Darmstadt) in inverse kinematics: Fe 56 +p, Fe 56 +Ti(nat), Xe 136 +p, Xe 136 +Ti(nat) a 1 A*GeV. The inverse kinematics allows to observe all particles without any threshold in energy. This is a great advantage compared to experiments in direct kinematics, because only in inverse kinematics it is possible to obtain complete velocity spectra (without a hole for low velocities) for fully identified isotopes. The complex shape of the velocity spectra allows to identify the different deexcitation channels and it clearly shows the transition from a chaotic-dominated process (Gaussian cloud in velocity space) to a direct Coulomb- (or eventually expansion-) dominated process (shell of a sphere in velocity space). Different possible descriptions of the reaction process are discussed, based either on asymmetric fission or multifragmentation. The resulting physical picture is especially interesting for the Fe 56 +p, and Xe 136 +p systems: proton induced collisions could result in the split of the system in two or more fragments due to a fast break-up process. In this case, the configuration of the break-up partition is very asymmetric. The discussion will be extended to other characteristics, like the restoring of nuclear structure features in the isotopic production and the temperature dependence of the isotopic composition of the residues. (author)

Adaptation and learning: characteristic time scales of performance dynamics.

Science.gov (United States)

Newell, Karl M; Mayer-Kress, Gottfried; Hong, S Lee; Liu, Yeou-Teh

2009-12-01

A multiple time scales landscape model is presented that reveals structures of performance dynamics that were not resolved in the traditional power law analysis of motor learning. It shows the co-existence of separate processes during and between practice sessions that evolve in two independent dimensions characterized by time scales that differ by about an order of magnitude. Performance along the slow persistent dimension of learning improves often as much and sometimes more during rest (memory consolidation and/or insight generation processes) than during a practice session itself. In contrast, the process characterized by the fast, transient dimension of adaptation reverses direction between practice sessions, thereby significantly degrading performance at the beginning of the next practice session (warm-up decrement). The theoretical model fits qualitatively and quantitatively the data from Snoddy's [Snoddy, G. S. (1926). Learning and stability. Journal of Applied Psychology, 10, 1-36] classic learning study of mirror tracing and other averaged and individual data sets, and provides a new account of the processes of change in adaptation and learning. 2009 Elsevier B.V. All rights reserved.

ARC: A compact, high-field, disassemblable fusion nuclear science facility and demonstration power plant

Science.gov (United States)

Sorbom, Brandon; Ball, Justin; Palmer, Timothy; Mangiarotti, Franco; Sierchio, Jennifer; Bonoli, Paul; Kasten, Cale; Sutherland, Derek; Barnard, Harold; Haakonsen, Christian; Goh, Jon; Sung, Choongki; Whyte, Dennis

2014-10-01

The Affordable, Robust, Compact (ARC) reactor conceptual design aims to reduce the size, cost, and complexity of a combined Fusion Nuclear Science Facility (FNSF) and demonstration fusion pilot power plant. ARC is a 270 MWe tokamak reactor with a major radius of 3.3 m, a minor radius of 1.1 m, and an on-axis magnetic field of 9.2 T. ARC has Rare Earth Barium Copper Oxide (REBCO) superconducting toroidal field coils with joints to allow disassembly, allowing for removal and replacement of the vacuum vessel as a single component. Inboard-launched current drive of 25 MW LHRF power and 13.6 MW ICRF power is used to provide a robust, steady state core plasma far from disruptive limits. ARC uses an all-liquid blanket, consisting of low pressure, slowly flowing Fluorine Lithium Beryllium (FLiBe) molten salt. The liquid blanket acts as a working fluid, coolant, and tritium breeder, and minimizes the solid material that can become activated. The large temperature range over which FLiBe is liquid permits blanket operation at 800-900 K with single phase fluid cooling and allows use of a high-efficiency Brayton cycle for electricity production in the secondary coolant loop.

Modeling Climate Responses to Spectral Solar Forcing on Centennial and Decadal Time Scales

Science.gov (United States)

Wen, G.; Cahalan, R.; Rind, D.; Jonas, J.; Pilewskie, P.; Harder, J.

2012-01-01

We report a series of experiments to explore clima responses to two types of solar spectral forcing on decadal and centennial time scales - one based on prior reconstructions, and another implied by recent observations from the SORCE (Solar Radiation and Climate Experiment) SIM (Spectral 1rradiance Monitor). We apply these forcings to the Goddard Institute for Space Studies (GISS) Global/Middle Atmosphere Model (GCMAM). that couples atmosphere with ocean, and has a model top near the mesopause, allowing us to examine the full response to the two solar forcing scenarios. We show different climate responses to the two solar forCing scenarios on decadal time scales and also trends on centennial time scales. Differences between solar maximum and solar minimum conditions are highlighted, including impacts of the time lagged reSponse of the lower atmosphere and ocean. This contrasts with studies that assume separate equilibrium conditions at solar maximum and minimum. We discuss model feedback mechanisms involved in the solar forced climate variations.

Rapid-mixing studies on the time-scale of radiation damage in cells

International Nuclear Information System (INIS)

Adams, G.E.; Michael, B.D.; Asquith, J.C.; Shenoy, M.A.; Watts, M.E.; Whillans, D.W.

1975-01-01

Rapid mixing studies were performed to determine the time scale of radiation damage in cells. There is evidence that the sensitizing effects of oxygen and other chemical dose-modifying agents on the response of cells to ionizing radiation involve fast free-radical processes. Fast response technique studies in bacterial systems have shown that extremely fast processes occur when the bacteria are exposed to oxygen or other dose-modifying agents during irradiation. The time scales observed were consistent with the involvement of fast free-radical reactions in the expression of these effects

Valuing Treatments for Parkinson Disease Incorporating Process Utility: Performance of Best-Worst Scaling, Time Trade-Off, and Visual Analogue Scales

NARCIS (Netherlands)

Weernink, Marieke Geertruida Maria; Groothuis-Oudshoorn, Catharina Gerarda Maria; IJzerman, Maarten Joost; van Til, Janine Astrid

2016-01-01

Objective The objective of this study was to compare treatment profiles including both health outcomes and process characteristics in Parkinson disease using best-worst scaling (BWS), time trade-off (TTO), and visual analogue scales (VAS). Methods From the model comprising of seven attributes with

Introducing English and German versions of the Adolescent Time Attitude Scale.

Science.gov (United States)

Worrell, Frank C; Mello, Zena R; Buhl, Monika

2013-08-01

In this study, the authors report on the development of English and German versions of the Adolescent Time Attitude Scale (ATAS). The ATAS consists of six subscales assessing Past Positive, Past Negative, Present Positive, Present Negative, Future Positive, and Future Negative time attitudes. The authors describe the development of the scales and present data on the reliability and structural validity of ATAS scores in samples of American (N = 300) and German (N = 316) adolescents. Internal consistency estimates for scores on the English and German versions of the ATAS were in the .70 to .80 range. Confirmatory factor analyses indicated that a six-factor structure yielded the best fit for scores and that the scores were invariant across samples.

Cycles, scaling and crossover phenomenon in length of the day (LOD) time series

Science.gov (United States)

Telesca, Luciano

2007-06-01

The dynamics of the temporal fluctuations of the length of the day (LOD) time series from January 1, 1962 to November 2, 2006 were investigated. The power spectrum of the whole time series has revealed annual, semi-annual, decadal and daily oscillatory behaviors, correlated with oceanic-atmospheric processes and interactions. The scaling behavior was analyzed by using the detrended fluctuation analysis (DFA), which has revealed two different scaling regimes, separated by a crossover timescale at approximately 23 days. Flicker-noise process can describe the dynamics of the LOD time regime involving intermediate and long timescales, while Brownian dynamics characterizes the LOD time series for small timescales.

Design and fabrication of a glovebox for the Plasma Hearth Process radioactive bench-scale system

International Nuclear Information System (INIS)

Wahlquist, D.R.

1996-01-01

This paper presents some of the design considerations and fabrication techniques for building a glovebox for the Plasma Hearth Process (PHP) radioactive bench-scale system. The PHP radioactive bench-scale system uses a plasma torch to process a variety of radioactive materials into a final vitrified waste form. The processed waste will contain plutonium and trace amounts of other radioactive materials. The glovebox used in this system is located directly below the plasma chamber and is called the Hearth Handling Enclosure (HHE). The HHE is designed to maintain a confinement boundary between the processed waste and the operator. Operations that take place inside the HHE include raising and lowering the hearth using a hydraulic lift table, transporting the hearth within the HHE using an overhead monorail and hoist system, sampling and disassembly of the processed waste and hearth, weighing the hearth, rebuilding a hearth, and sampling HEPA filters. The PHP radioactive bench-scale system is located at the TREAT facility at Argonne National Laboratory-West in Idaho Falls, Idaho

A hybrid procedure for MSW generation forecasting at multiple time scales in Xiamen City, China.

Science.gov (United States)

Xu, Lilai; Gao, Peiqing; Cui, Shenghui; Liu, Chun

2013-06-01

Accurate forecasting of municipal solid waste (MSW) generation is crucial and fundamental for the planning, operation and optimization of any MSW management system. Comprehensive information on waste generation for month-scale, medium-term and long-term time scales is especially needed, considering the necessity of MSW management upgrade facing many developing countries. Several existing models are available but of little use in forecasting MSW generation at multiple time scales. The goal of this study is to propose a hybrid model that combines the seasonal autoregressive integrated moving average (SARIMA) model and grey system theory to forecast MSW generation at multiple time scales without needing to consider other variables such as demographics and socioeconomic factors. To demonstrate its applicability, a case study of Xiamen City, China was performed. Results show that the model is robust enough to fit and forecast seasonal and annual dynamics of MSW generation at month-scale, medium- and long-term time scales with the desired accuracy. In the month-scale, MSW generation in Xiamen City will peak at 132.2 thousand tonnes in July 2015 - 1.5 times the volume in July 2010. In the medium term, annual MSW generation will increase to 1518.1 thousand tonnes by 2015 at an average growth rate of 10%. In the long term, a large volume of MSW will be output annually and will increase to 2486.3 thousand tonnes by 2020 - 2.5 times the value for 2010. The hybrid model proposed in this paper can enable decision makers to develop integrated policies and measures for waste management over the long term. Copyright © 2013 Elsevier Ltd. All rights reserved.

The fission time scale measured with an atomic clock

NARCIS (Netherlands)

Kravchuk, VL; Wilschut, HW; Hunyadi, M; Kopecky, S; Lohner, H; Rogachevskiy, A; Siemssen, RH; Krasznahorkay, A; Hamilton, JH; Ramayya, AV; Carter, HK

2003-01-01

We present a new direct method of measuring the fission absolute time scale using an atomic clock based on the lifetime of a vacancy in the atomic K-shell. We studied the reaction Ne-20 + Th-232 -> O-16 + U-236* at 30 MeV/u. The excitation energy of about 115 MeV in such a reaction is in the range

Time scales of foam stability in shallow conduits: Insights from analogue experiments

Science.gov (United States)

Spina, L.; Scheu, B.; Cimarelli, C.; Arciniega-Ceballos, A.; Dingwell, D. B.

2016-10-01

Volcanic systems can exhibit periodical trends in degassing activity, characterized by a wide range of time scales. Understanding the dynamics that control such periodic behavior can provide a picture of the processes occurring in the feeding system. Toward this end, we analyzed the periodicity of outgassing in a series of decompression experiments performed on analogue material (argon-saturated silicone oil plus glass beads/fibers) scaled to serve as models of basaltic magma. To define the effects of liquid viscosity and crystal content on the time scale of outgassing, we investigated both: (1) pure liquid systems, at differing viscosities (100 and 1000 Pa s), and (2) particle-bearing suspensions (diluted and semidiluted). The results indicate that under dynamic conditions (e.g., decompressive bubble growth and fluid ascent within the conduit), the periodicity of foam disruption may be up to several orders of magnitude less than estimates based on the analysis of static conditions. This difference in foam disruption time scale is inferred to result from the contribution of bubble shear and bubble growth to inter-bubble film thinning. The presence of particles in the semidiluted regime is further linked to shorter bubble bursting times, likely resulting from contributions of the presence of a solid network and coalescence processes to the relative increase in bubble breakup rates. Finally, it is argued that these experiments represent a good analogue of gas-piston activity (i.e., the periodical rise-and-fall of a basaltic lava lake surface), implying a dominant role for shallow foam accumulation as a source process for these phenomena.

Entangled time in flocking: Multi-time-scale interaction reveals emergence of inherent noise.

Science.gov (United States)

Niizato, Takayuki; Murakami, Hisashi

2018-01-01

Collective behaviors that seem highly ordered and result in collective alignment, such as schooling by fish and flocking by birds, arise from seamless shuffling (such as super-diffusion) and bustling inside groups (such as Lévy walks). However, such noisy behavior inside groups appears to preclude the collective behavior: intuitively, we expect that noisy behavior would lead to the group being destabilized and broken into small sub groups, and high alignment seems to preclude shuffling of neighbors. Although statistical modeling approaches with extrinsic noise, such as the maximum entropy approach, have provided some reasonable descriptions, they ignore the cognitive perspective of the individuals. In this paper, we try to explain how the group tendency, that is, high alignment, and highly noisy individual behavior can coexist in a single framework. The key aspect of our approach is multi-time-scale interaction emerging from the existence of an interaction radius that reflects short-term and long-term predictions. This multi-time-scale interaction is a natural extension of the attraction and alignment concept in many flocking models. When we apply this method in a two-dimensional model, various flocking behaviors, such as swarming, milling, and schooling, emerge. The approach also explains the appearance of super-diffusion, the Lévy walk in groups, and local equilibria. At the end of this paper, we discuss future developments, including extending our model to three dimensions.

Ns-scaled time-gated fluorescence lifetime imaging for forensic document examination

Science.gov (United States)

Zhong, Xin; Wang, Xinwei; Zhou, Yan

2018-01-01

A method of ns-scaled time-gated fluorescence lifetime imaging (TFLI) is proposed to distinguish different fluorescent substances in forensic document examination. Compared with Video Spectral Comparator (VSC) which can examine fluorescence intensity images only, TFLI can detect questioned documents like falsification or alteration. TFLI system can enhance weak signal by accumulation method. The two fluorescence intensity images of the interval delay time tg are acquired by ICCD and fitted into fluorescence lifetime image. The lifetimes of fluorescence substances are represented by different colors, which make it easy to detect the fluorescent substances and the sequence of handwritings. It proves that TFLI is a powerful tool for forensic document examination. Furthermore, the advantages of TFLI system are ns-scaled precision preservation and powerful capture capability.

Time Scale Inequalities of the Ostrowski Type for Functions Differentiable on the Coordinates

Directory of Open Access Journals (Sweden)

Eze R. Nwaeze

2018-01-01

Full Text Available In 2016, some inequalities of the Ostrowski type for functions (of two variables differentiable on the coordinates were established. In this paper, we extend these results to an arbitrary time scale by means of a parameter λ∈0,1. The aforementioned results are regained for the case when the time scale T=R. Besides extension, our results are employed to the continuous and discrete calculus to get some new inequalities in this direction.

Antipersistent dynamics in short time scale variability of self-potential signals

OpenAIRE

Cuomo, V.; Lanfredi, M.; Lapenna, V.; Macchiato, M.; Ragosta, M.; Telesca, L.

2000-01-01

Time scale properties of self-potential signals are investigated through the analysis of the second order structure function (variogram), a powerful tool to investigate the spatial and temporal variability of observational data. In this work we analyse two sequences of self-potential values measured by means of a geophysical monitoring array located in a seismically active area of Southern Italy. The range of scales investigated goes from a few minutes to several days. It is shown that signal...

Two-time scale subordination in physical processes with long-term memory

International Nuclear Information System (INIS)

Stanislavsky, Aleksander; Weron, Karina

2008-01-01

We describe dynamical processes in continuous media with a long-term memory. Our consideration is based on a stochastic subordination idea and concerns two physical examples in detail. First we study a temporal evolution of the species concentration in a trapping reaction in which a diffusing reactant is surrounded by a sea of randomly moving traps. The analysis uses the random-variable formalism of anomalous diffusive processes. We find that the empirical trapping-reaction law, according to which the reactant concentration decreases in time as a product of an exponential and a stretched exponential function, can be explained by a two-time scale subordination of random processes. Another example is connected with a state equation for continuous media with memory. If the pressure and the density of a medium are subordinated in two different random processes, then the ordinary state equation becomes fractional with two-time scales. This allows one to arrive at the Bagley-Torvik type of state equation

Multi-time, multi-scale correlation functions in turbulence and in turbulent models

NARCIS (Netherlands)

Biferale, L.; Boffetta, G.; Celani, A.; Toschi, F.

1999-01-01

A multifractal-like representation for multi-time, multi-scale velocity correlation in turbulence and dynamical turbulent models is proposed. The importance of subleading contributions to time correlations is highlighted. The fulfillment of the dynamical constraints due to the equations of motion is

Overcoming time scale and finite size limitations to compute nucleation rates from small scale well tempered metadynamics simulations

Science.gov (United States)

Salvalaglio, Matteo; Tiwary, Pratyush; Maggioni, Giovanni Maria; Mazzotti, Marco; Parrinello, Michele

2016-12-01

Condensation of a liquid droplet from a supersaturated vapour phase is initiated by a prototypical nucleation event. As such it is challenging to compute its rate from atomistic molecular dynamics simulations. In fact at realistic supersaturation conditions condensation occurs on time scales that far exceed what can be reached with conventional molecular dynamics methods. Another known problem in this context is the distortion of the free energy profile associated to nucleation due to the small, finite size of typical simulation boxes. In this work the problem of time scale is addressed with a recently developed enhanced sampling method while contextually correcting for finite size effects. We demonstrate our approach by studying the condensation of argon, and showing that characteristic nucleation times of the order of magnitude of hours can be reliably calculated. Nucleation rates spanning a range of 10 orders of magnitude are computed at moderate supersaturation levels, thus bridging the gap between what standard molecular dynamics simulations can do and real physical systems.

Time scales of magma transport and mixing at Kīlauea Volcano, Hawai’i

OpenAIRE

Rae, Auriol S.P.; Edmonds, Marie; Maclennan, John; Morgan, Daniel; Houghton, Bruce; Hartley, Margaret E.; Sides, Isobel

2016-01-01

Modeling of volcanic processes is limited by a lack of knowledge of the time scales of storage, mixing, and final ascent of magmas into the shallowest portions of volcanic plumbing systems immediately prior to eruption. It is impossible to measure these time scales directly; however, micro-analytical techniques provide indirect estimates based on the extent of diffusion of species through melts and crystals. We use diffusion in olivine phenocrysts from the A.D. 1959 Kīlauea Iki (Hawai‘i, USA)...

Bounds of Double Integral Dynamic Inequalities in Two Independent Variables on Time Scales

Directory of Open Access Journals (Sweden)

S. H. Saker

2011-01-01

Full Text Available Our aim in this paper is to establish some explicit bounds of the unknown function in a certain class of nonlinear dynamic inequalities in two independent variables on time scales which are unbounded above. These on the one hand generalize and on the other hand furnish a handy tool for the study of qualitative as well as quantitative properties of solutions of partial dynamic equations on time scales. Some examples are considered to demonstrate the applications of the results.

Optimal dynamic voltage scaling for wireless sensor nodes with real-time constraints

Science.gov (United States)

Cassandras, Christos G.; Zhuang, Shixin

2005-11-01

Sensors are increasingly embedded in manufacturing systems and wirelessly networked to monitor and manage operations ranging from process and inventory control to tracking equipment and even post-manufacturing product monitoring. In building such sensor networks, a critical issue is the limited and hard to replenish energy in the devices involved. Dynamic voltage scaling is a technique that controls the operating voltage of a processor to provide desired performance while conserving energy and prolonging the overall network's lifetime. We consider such power-limited devices processing time-critical tasks which are non-preemptive, aperiodic and have uncertain arrival times. We treat voltage scaling as a dynamic optimization problem whose objective is to minimize energy consumption subject to hard or soft real-time execution constraints. In the case of hard constraints, we build on prior work (which engages a voltage scaling controller at task completion times) by developing an intra-task controller that acts at all arrival times of incoming tasks. We show that this optimization problem can be decomposed into two simpler ones whose solution leads to an algorithm that does not actually require solving any nonlinear programming problems. In the case of soft constraints, this decomposition must be partly relaxed, but it still leads to a scalable (linear in the number of tasks) algorithm. Simulation results are provided to illustrate performance improvements in systems with intra-task controllers compared to uncontrolled systems or those using inter-task control.

Timing of Formal Phase Safety Reviews for Large-Scale Integrated Hazard Analysis

Science.gov (United States)

Massie, Michael J.; Morris, A. Terry

2010-01-01

Integrated hazard analysis (IHA) is a process used to identify and control unacceptable risk. As such, it does not occur in a vacuum. IHA approaches must be tailored to fit the system being analyzed. Physical, resource, organizational and temporal constraints on large-scale integrated systems impose additional direct or derived requirements on the IHA. The timing and interaction between engineering and safety organizations can provide either benefits or hindrances to the overall end product. The traditional approach for formal phase safety review timing and content, which generally works well for small- to moderate-scale systems, does not work well for very large-scale integrated systems. This paper proposes a modified approach to timing and content of formal phase safety reviews for IHA. Details of the tailoring process for IHA will describe how to avoid temporary disconnects in major milestone reviews and how to maintain a cohesive end-to-end integration story particularly for systems where the integrator inherently has little to no insight into lower level systems. The proposal has the advantage of allowing the hazard analysis development process to occur as technical data normally matures.

The plasma transport equations derived by multiple time-scale expansions and turbulent transport. I. General theory

International Nuclear Information System (INIS)

Edenstrasser, J.W.

1995-01-01

A multiple time-scale derivative expansion scheme is applied to the dimensionless Fokker--Planck equation and to Maxwell's equations, where the parameter range of a typical fusion plasma was assumed. Within kinetic theory, the four time scales considered are those of Larmor gyration, particle transit, collisions, and classical transport. The corresponding magnetohydrodynamic (MHD) time scales are those of ion Larmor gyration, Alfven, MHD collision, and resistive diffusion. The solution of the zeroth-order equations results in the force-free equilibria and ideal Ohm's law. The solution of the first-order equations leads under the assumption of a weak collisional plasma to the ideal MHD equations. On the MHD-collision time scale, not only the full set of the MHD transport equations is obtained, but also turbulent terms, where the related transport quantities are one order in the expansion parameter larger than those of classical transport. Finally, at the resistive diffusion time scale the known transport equations are arrived at including, however, also turbulent contributions. copyright 1995 American Institute of Physics

BOX-COX REGRESSION METHOD IN TIME SCALING

Directory of Open Access Journals (Sweden)

ATİLLA GÖKTAŞ

2013-06-01

Full Text Available Box-Cox regression method with λj, for j = 1, 2, ..., k, power transformation can be used when dependent variable and error term of the linear regression model do not satisfy the continuity and normality assumptions. The situation obtaining the smallest mean square error  when optimum power λj, transformation for j = 1, 2, ..., k, of Y has been discussed. Box-Cox regression method is especially appropriate to adjust existence skewness or heteroscedasticity of error terms for a nonlinear functional relationship between dependent and explanatory variables. In this study, the advantage and disadvantage use of Box-Cox regression method have been discussed in differentiation and differantial analysis of time scale concept.

Time scale of scour around a pile in combined waves and current

DEFF Research Database (Denmark)

Petersen, Thor Ugelvig; Sumer, B. Mutlu; Fredsøe, Jørgen

The time scale of the scour process around a circular vertical pile is studied in combined waves and current. A series of tests were carried out in a flume with pile diameters 40 mm and 75 mm, in both steady current, waves and combined waves and current. In the combined wave and current flow regime...... the waves and the current were co-directional. All the tests were conducted in the live bed regime. The time scale of scour in combined waves and current is governed by three parameters, namely the current-velocity-to-wave-velocity ratio (Ucw), the Keulegan–Carpenter number (KC) and Shields parameter (Θw...

The swan song in context: long-time-scale X-ray variability of NGC 4051

Science.gov (United States)

Uttley, P.; McHardy, I. M.; Papadakis, I. E.; Guainazzi, M.; Fruscione, A.

1999-07-01

On 1998 May 9-11, the highly variable, low-luminosity Seyfert 1 galaxy NGC 4051 was observed in an unusual low-flux state by BeppoSAX, RXTE and EUVE. We present fits of the 4-15keV RXTE spectrum and BeppoSAX MECS spectrum obtained during this observation, which are consistent with the interpretation that the source had switched off, leaving only the spectrum of pure reflection from distant cold matter. We place this result in context by showing the X-ray light curve of NGC 4051 obtained by our RXTE monitoring campaign over the past two and a half years, which shows that the low state lasted for ~150d before the May observations (implying that the reflecting material is >10^17cm from the continuum source) and forms part of a light curve showing distinct variations in long-term average flux over time-scales > months. We show that the long-time-scale component to X-ray variability is intrinsic to the primary continuum and is probably distinct from the variability at shorter time-scales. The long-time-scale component to variability maybe associated with variations in the accretion flow of matter on to the central black hole. As the source approaches the low state, the variability process becomes non-linear. NGC 4051 may represent a microcosm of all X-ray variability in radio-quiet active galactic nuclei (AGNs), displaying in a few years a variety of flux states and variability properties which more luminous AGNs may pass through on time-scales of decades to thousands of years.

Time scales of the stick–slip dynamics of the peeling of an adhesive tape

Science.gov (United States)

Mishra, Nachiketa; Parida, Nigam Chandra; Raha, Soumyendu

2015-01-01

The stick–slip dynamics of the peeling of an adhesive tape is characterized by bifurcations that have been experimentally well studied. In this work, we investigate the time scale in which the the stick–slips happen leading to the bifurcations. This is fundamental to understanding the triboluminescence and acoustic emissions associated with the bifurcations. We establish a relationship between the time scale of the bifurcations and the inherent mathematical structure of the peeling dynamics by studying a characteristic time quantity associated with the dynamics. PMID:25663802

Modeling and Validating Time, Buffering, and Utilization of a Large-Scale, Real-Time Data Acquisition System

CERN Document Server

AUTHOR|(SzGeCERN)756497; The ATLAS collaboration; Garcia Garcia, Pedro Javier; Vandelli, Wainer; Froening, Holger

2017-01-01

Data acquisition systems for large-scale high-energy physics experiments have to handle hundreds of gigabytes per second of data, and are typically realized as specialized data centers that connect a very large number of front-end electronics devices to an event detection and storage system. The design of such systems is often based on many assumptions, small-scale experiments and a substantial amount of over-provisioning. In this work, we introduce a discrete event-based simulation tool that models the data flow of the current ATLAS data acquisition system, with the main goal to be accurate with regard to the main operational characteristics. We measure buffer occupancy counting the number of elements in buffers, resource utilization measuring output bandwidth and counting the number of active processing units, and their time evolution by comparing data over many consecutive and small periods of time. We perform studies on the error of simulation when comparing the results to a large amount of real-world ope...

Modeling and Validating Time, Buffering, and Utilization of a Large-Scale, Real-Time Data Acquisition System

CERN Document Server

AUTHOR|(SzGeCERN)756497; The ATLAS collaboration; Garcia Garcia, Pedro Javier; Vandelli, Wainer; Froening, Holger

2017-01-01

Data acquisition systems for large-scale high-energy physics experiments have to handle hundreds of gigabytes per second of data, and are typically implemented as specialized data centers that connect a very large number of front-end electronics devices to an event detection and storage system. The design of such systems is often based on many assumptions, small-scale experiments and a substantial amount of over-provisioning. In this paper, we introduce a discrete event-based simulation tool that models the dataflow of the current ATLAS data acquisition system, with the main goal to be accurate with regard to the main operational characteristics. We measure buffer occupancy counting the number of elements in buffers; resource utilization measuring output bandwidth and counting the number of active processing units, and their time evolution by comparing data over many consecutive and small periods of time. We perform studies on the error in simulation when comparing the results to a large amount of real-world ...

Retention of habitat complexity minimizes disassembly of reef fish communities following disturbance: a large-scale natural experiment.

Directory of Open Access Journals (Sweden)

Michael J Emslie

Full Text Available High biodiversity ecosystems are commonly associated with complex habitats. Coral reefs are highly diverse ecosystems, but are under increasing pressure from numerous stressors, many of which reduce live coral cover and habitat complexity with concomitant effects on other organisms such as reef fishes. While previous studies have highlighted the importance of habitat complexity in structuring reef fish communities, they employed gradient or meta-analyses which lacked a controlled experimental design over broad spatial scales to explicitly separate the influence of live coral cover from overall habitat complexity. Here a natural experiment using a long term (20 year, spatially extensive (∼ 115,000 kms(2 dataset from the Great Barrier Reef revealed the fundamental importance of overall habitat complexity for reef fishes. Reductions of both live coral cover and habitat complexity had substantial impacts on fish communities compared to relatively minor impacts after major reductions in coral cover but not habitat complexity. Where habitat complexity was substantially reduced, species abundances broadly declined and a far greater number of fish species were locally extirpated, including economically important fishes. This resulted in decreased species richness and a loss of diversity within functional groups. Our results suggest that the retention of habitat complexity following disturbances can ameliorate the impacts of coral declines on reef fishes, so preserving their capacity to perform important functional roles essential to reef resilience. These results add to a growing body of evidence about the importance of habitat complexity for reef fishes, and represent the first large-scale examination of this question on the Great Barrier Reef.

Modeling and simulation of nuclear fuel in scenarios with long time scales

Energy Technology Data Exchange (ETDEWEB)

Espinosa, Carlos E.; Bodmann, Bardo E.J., E-mail: eduardo.espinosa@ufrgs.br, E-mail: bardo.bodmann@ufrgs.br [Universidade Federal do Rio Grande do Sul (DENUC/PROMEC/UFRGS), Porto Alegre, RS (Brazil). Departamento de Engenharia Nuclear. Programa de Pos Graduacao em Engenharia Mecanica

2015-07-01

Nuclear reactors play a key role in defining the energy matrix. A study by the Fraunhofer Society shows in different time scales for long periods of time the distribution of energy sources. Regardless of scale, the use of nuclear energy is practically constant. In these scenarios, the nuclear fuel behavior over time is of interest. For kinetics of long-term scales, changing the chemical composition of fuel is significant. Thus, it is appropriate to consider fission products called neutron poisons. Such products are of interest in the nuclear reactor, since they become parasitic neutron absorbers and result in long thermal heat sources. The objective of this work is to solve the kinetics system coupled to neutron poison products. To solve this system, we use similar ideas to the method of Adomian decomposition. Initially, one separates the system of equations as the sum of a linear part and a non-linear part in order to solve a recursive system. The nonlinearity is treated as Adomian polynomial. We present numerical results of the effects of changing the power of a reactor, scenarios such as start-up and shut-down. For these results we consider time dependent reactivity, such as linear reactivity, quadratic polynomial and oscillatory. With these results one can simulate the chemical composition of the fuel due to the reuse of the spent fuel in subsequent cycles. (author)

Modeling and simulation of nuclear fuel in scenarios with long time scales

International Nuclear Information System (INIS)

Espinosa, Carlos E.; Bodmann, Bardo E.J.

2015-01-01

Nuclear reactors play a key role in defining the energy matrix. A study by the Fraunhofer Society shows in different time scales for long periods of time the distribution of energy sources. Regardless of scale, the use of nuclear energy is practically constant. In these scenarios, the nuclear fuel behavior over time is of interest. For kinetics of long-term scales, changing the chemical composition of fuel is significant. Thus, it is appropriate to consider fission products called neutron poisons. Such products are of interest in the nuclear reactor, since they become parasitic neutron absorbers and result in long thermal heat sources. The objective of this work is to solve the kinetics system coupled to neutron poison products. To solve this system, we use similar ideas to the method of Adomian decomposition. Initially, one separates the system of equations as the sum of a linear part and a non-linear part in order to solve a recursive system. The nonlinearity is treated as Adomian polynomial. We present numerical results of the effects of changing the power of a reactor, scenarios such as start-up and shut-down. For these results we consider time dependent reactivity, such as linear reactivity, quadratic polynomial and oscillatory. With these results one can simulate the chemical composition of the fuel due to the reuse of the spent fuel in subsequent cycles. (author)

Universal Linear Scaling of Permeability and Time for Heterogeneous Fracture Dissolution

Science.gov (United States)

Wang, L.; Cardenas, M. B.

2017-12-01

Fractures are dynamically changing over geological time scale due to mechanical deformation and chemical reactions. However, the latter mechanism remains poorly understood with respect to the expanding fracture, which leads to a positively coupled flow and reactive transport processes, i.e., as a fracture expands, so does its permeability (k) and thus flow and reactive transport processes. To unravel this coupling, we consider a self-enhancing process that leads to fracture expansion caused by acidic fluid, i.e., CO2-saturated brine dissolving calcite fracture. We rigorously derive a theory, for the first time, showing that fracture permeability increases linearly with time [Wang and Cardenas, 2017]. To validate this theory, we resort to the direct simulation that solves the Navier-Stokes and Advection-Diffusion equations with a moving mesh according to the dynamic dissolution process in two-dimensional (2D) fractures. We find that k slowly increases first until the dissolution front breakthrough the outbound when we observe a rapid k increase, i.e., the linear time-dependence of k occurs. The theory agrees well with numerical observations across a broad range of Peclet and Damkohler numbers through homogeneous and heterogeneous 2D fractures. Moreover, the theory of linear scaling relationship between k and time matches well with experimental observations of three-dimensional (3D) fractures' dissolution. To further attest to our theory's universality for 3D heterogeneous fractures across a broad range of roughness and correlation length of aperture field, we develop a depth-averaged model that simulates the process-based reactive transport. The simulation results show that, regardless of a wide variety of dissolution patterns such as the presence of dissolution fingers and preferential dissolution paths, the linear scaling relationship between k and time holds. Our theory sheds light on predicting permeability evolution in many geological settings when the self

Determination of C0-60 in Cobalt Slugs and Slabs and Radionuclides in Curium Sampler Slugs L-Reactor Disassembly Basin

International Nuclear Information System (INIS)

Casella, V.R.

2004-01-01

Co-60 was historically produced in the SRS reactors. Cobalt slugs were irradiated in the early 1970s. Post-production, remaining cobalt slugs (including slab form) were consolidated for storage. There are approximately nine hundred cobalt slugs currently stored awaiting final disposition. These slugs had historically incomplete documentation for activity rates; therefore, assaying was required in order to determine their activity levels. Since the gamma dose rate from these slugs is extremely high, the most cost effective way to shield a source of this magnitude from personnel and the radiation detector was to use the basin water in which the slugs are stored as the shield. A sodium iodide gamma detector was placed above a specially designed air collimator assembly, so that slug was at least eight feet from the detector and was shielded by the basin water. Using a sodium iodide detector and multichannel analyzer system and an underwater collimator assembly, Co-60 concentrations we re determined for Disassembly Basin cobalt slugs and slabs and 18 curium sampler slugs. The total activity of all of the assayed slugs summed to 31,783 curies. From the Co-60 concentrations of the curium sampler slugs, the irradiation flux was determined for the known irradiation time. The amounts of Pu-238, 239, 240, 241, 242; Am-241, 243; and Cm-242, 244 produced were then obtained based on the original amount of Pu-239 irradiated

Scale invariance in chaotic time series: Classical and quantum examples

Science.gov (United States)

Landa, Emmanuel; Morales, Irving O.; Stránský, Pavel; Fossion, Rubén; Velázquez, Victor; López Vieyra, J. C.; Frank, Alejandro

Important aspects of chaotic behavior appear in systems of low dimension, as illustrated by the Map Module 1. It is indeed a remarkable fact that all systems tha make a transition from order to disorder display common properties, irrespective of their exacta functional form. We discuss evidence for 1/f power spectra in the chaotic time series associated in classical and quantum examples, the one-dimensional map module 1 and the spectrum of 48Ca. A Detrended Fluctuation Analysis (DFA) method is applied to investigate the scaling properties of the energy fluctuations in the spectrum of 48Ca obtained with a large realistic shell model calculation (ANTOINE code) and with a random shell model (TBRE) calculation also in the time series obtained with the map mod 1. We compare the scale invariant properties of the 48Ca nuclear spectrum sith similar analyses applied to the RMT ensambles GOE and GDE. A comparison with the corresponding power spectra is made in both cases. The possible consequences of the results are discussed.

Assessment of the methods for determining net radiation at different time-scales of meteorological variables

Directory of Open Access Journals (Sweden)

Ni An

2017-04-01

Full Text Available When modeling the soil/atmosphere interaction, it is of paramount importance to determine the net radiation flux. There are two common calculation methods for this purpose. Method 1 relies on use of air temperature, while Method 2 relies on use of both air and soil temperatures. Nowadays, there has been no consensus on the application of these two methods. In this study, the half-hourly data of solar radiation recorded at an experimental embankment are used to calculate the net radiation and long-wave radiation at different time-scales (half-hourly, hourly, and daily using the two methods. The results show that, compared with Method 2 which has been widely adopted in agronomical, geotechnical and geo-environmental applications, Method 1 is more feasible for its simplicity and accuracy at shorter time-scale. Moreover, in case of longer time-scale, daily for instance, less variations of net radiation and long-wave radiation are obtained, suggesting that no detailed soil temperature variations can be obtained. In other words, shorter time-scales are preferred in determining net radiation flux.

Principal and nonprincipal solutions of symplectic dynamic systems on time scales

Directory of Open Access Journals (Sweden)

Ondrej Dosly

2000-01-01

Full Text Available We establish the concept of the principal and nonprincipal solution for the so-called symplectic dynamic systems on time scales. We also present a brief survey of the history of these concept for differential and difference equations.

Time-variable gravity potential components for optical clock comparisons and the definition of international time scales

International Nuclear Information System (INIS)

Voigt, C.; Denker, H.; Timmen, L.

2016-01-01

The latest generation of optical atomic clocks is approaching the level of one part in 10 18 in terms of frequency stability and uncertainty. For clock comparisons and the definition of international time scales, a relativistic redshift effect of the clock frequencies has to be taken into account at a corresponding uncertainty level of about 0.1 m 2 s -2 and 0.01 m in terms of gravity potential and height, respectively. Besides the predominant static part of the gravity potential, temporal variations must be considered in order to avoid systematic frequency shifts. Time-variable gravity potential components induced by tides and non-tidal mass redistributions are investigated with regard to the level of one part in 10 18 . The magnitudes and dominant time periods of the individual gravity potential contributions are investigated globally and for specific laboratory sites together with the related uncertainty estimates. The basics of the computation methods are presented along with the applied models, data sets and software. Solid Earth tides contribute by far the most dominant signal with a global maximum amplitude of 4.2 m 2 s -2 for the potential and a range (maximum-to-minimum) of up to 1.3 and 10.0 m 2 s -2 in terms of potential differences between specific laboratories over continental and intercontinental scales, respectively. Amplitudes of the ocean tidal loading potential can amount up to 1.25 m 2 s -2 , while the range of the potential between specific laboratories is 0.3 and 1.1 m 2 s -2 over continental and intercontinental scales, respectively. These are the only two contributors being relevant at a 10 -17 level. However, several other time-variable potential effects can particularly affect clock comparisons at the 10 -18 level. Besides solid Earth pole tides, these are non-tidal mass redistributions in the atmosphere, the oceans and the continental water storage. (authors)

Large-scale machine learning and evaluation platform for real-time traffic surveillance

Science.gov (United States)

Eichel, Justin A.; Mishra, Akshaya; Miller, Nicholas; Jankovic, Nicholas; Thomas, Mohan A.; Abbott, Tyler; Swanson, Douglas; Keller, Joel

2016-09-01

In traffic engineering, vehicle detectors are trained on limited datasets, resulting in poor accuracy when deployed in real-world surveillance applications. Annotating large-scale high-quality datasets is challenging. Typically, these datasets have limited diversity; they do not reflect the real-world operating environment. There is a need for a large-scale, cloud-based positive and negative mining process and a large-scale learning and evaluation system for the application of automatic traffic measurements and classification. The proposed positive and negative mining process addresses the quality of crowd sourced ground truth data through machine learning review and human feedback mechanisms. The proposed learning and evaluation system uses a distributed cloud computing framework to handle data-scaling issues associated with large numbers of samples and a high-dimensional feature space. The system is trained using AdaBoost on 1,000,000 Haar-like features extracted from 70,000 annotated video frames. The trained real-time vehicle detector achieves an accuracy of at least 95% for 1/2 and about 78% for 19/20 of the time when tested on ˜7,500,000 video frames. At the end of 2016, the dataset is expected to have over 1 billion annotated video frames.

Modeling and control of a large nuclear reactor. A three-time-scale approach

Energy Technology Data Exchange (ETDEWEB)

Shimjith, S.R. [Indian Institute of Technology Bombay, Mumbai (India); Bhabha Atomic Research Centre, Mumbai (India); Tiwari, A.P. [Bhabha Atomic Research Centre, Mumbai (India); Bandyopadhyay, B. [Indian Institute of Technology Bombay, Mumbai (India). IDP in Systems and Control Engineering

2013-07-01

Recent research on Modeling and Control of a Large Nuclear Reactor. Presents a three-time-scale approach. Written by leading experts in the field. Control analysis and design of large nuclear reactors requires a suitable mathematical model representing the steady state and dynamic behavior of the reactor with reasonable accuracy. This task is, however, quite challenging because of several complex dynamic phenomena existing in a reactor. Quite often, the models developed would be of prohibitively large order, non-linear and of complex structure not readily amenable for control studies. Moreover, the existence of simultaneously occurring dynamic variations at different speeds makes the mathematical model susceptible to numerical ill-conditioning, inhibiting direct application of standard control techniques. This monograph introduces a technique for mathematical modeling of large nuclear reactors in the framework of multi-point kinetics, to obtain a comparatively smaller order model in standard state space form thus overcoming these difficulties. It further brings in innovative methods for controller design for systems exhibiting multi-time-scale property, with emphasis on three-time-scale systems.

Vibration amplitude rule study for rotor under large time scale

International Nuclear Information System (INIS)

Yang Xuan; Zuo Jianli; Duan Changcheng

2014-01-01

The rotor is an important part of the rotating machinery; its vibration performance is one of the important factors affecting the service life. This paper presents both theoretical analyses and experimental demonstrations of the vibration rule of the rotor under large time scales. The rule can be used for the service life estimation of the rotor. (authors)

Non-Abelian Kubo formula and the multiple time-scale method

International Nuclear Information System (INIS)

Zhang, X.; Li, J.

1996-01-01

The non-Abelian Kubo formula is derived from the kinetic theory. That expression is compared with the one obtained using the eikonal for a Chern endash Simons theory. The multiple time-scale method is used to study the non-Abelian Kubo formula, and the damping rate for longitudinal color waves is computed. copyright 1996 Academic Press, Inc

Transport on intermediate time scales in flows with cat's eye patterns

Science.gov (United States)

Pöschke, Patrick; Sokolov, Igor M.; Zaks, Michael A.; Nepomnyashchy, Alexander A.

2017-12-01

We consider the advection-diffusion transport of tracers in a one-parameter family of plane periodic flows where the patterns of streamlines feature regions of confined circulation in the shape of "cat's eyes," separated by meandering jets with ballistic motion inside them. By varying the parameter, we proceed from the regular two-dimensional lattice of eddies without jets to the sinusoidally modulated shear flow without eddies. When a weak thermal noise is added, i.e., at large Péclet numbers, several intermediate time scales arise, with qualitatively and quantitatively different transport properties: depending on the parameter of the flow, the initial position of a tracer, and the aging time, motion of the tracers ranges from subdiffusive to superballistic. We report on results of extensive numerical simulations of the mean-squared displacement for different initial conditions in ordinary and aged situations. These results are compared with a theory based on a Lévy walk that describes the intermediate-time ballistic regime and gives a reasonable description of the behavior for a certain class of initial conditions. The interplay of the walk process with internal circulation dynamics in the trapped state results at intermediate time scales in nonmonotonic characteristics of aging not captured by the Lévy walk model.

Multidimensional scaling analysis of financial time series based on modified cross-sample entropy methods

Science.gov (United States)

He, Jiayi; Shang, Pengjian; Xiong, Hui

2018-06-01

Stocks, as the concrete manifestation of financial time series with plenty of potential information, are often used in the study of financial time series. In this paper, we utilize the stock data to recognize their patterns through out the dissimilarity matrix based on modified cross-sample entropy, then three-dimensional perceptual maps of the results are provided through multidimensional scaling method. Two modified multidimensional scaling methods are proposed in this paper, that is, multidimensional scaling based on Kronecker-delta cross-sample entropy (MDS-KCSE) and multidimensional scaling based on permutation cross-sample entropy (MDS-PCSE). These two methods use Kronecker-delta based cross-sample entropy and permutation based cross-sample entropy to replace the distance or dissimilarity measurement in classical multidimensional scaling (MDS). Multidimensional scaling based on Chebyshev distance (MDSC) is employed to provide a reference for comparisons. Our analysis reveals a clear clustering both in synthetic data and 18 indices from diverse stock markets. It implies that time series generated by the same model are easier to have similar irregularity than others, and the difference in the stock index, which is caused by the country or region and the different financial policies, can reflect the irregularity in the data. In the synthetic data experiments, not only the time series generated by different models can be distinguished, the one generated under different parameters of the same model can also be detected. In the financial data experiment, the stock indices are clearly divided into five groups. Through analysis, we find that they correspond to five regions, respectively, that is, Europe, North America, South America, Asian-Pacific (with the exception of mainland China), mainland China and Russia. The results also demonstrate that MDS-KCSE and MDS-PCSE provide more effective divisions in experiments than MDSC.

Scaling in Free-Swimming Fish and Implications for Measuring Size-at-Time in the Wild

Science.gov (United States)

Broell, Franziska; Taggart, Christopher T.

2015-01-01

This study was motivated by the need to measure size-at-age, and thus growth rate, in fish in the wild. We postulated that this could be achieved using accelerometer tags based first on early isometric scaling models that hypothesize that similar animals should move at the same speed with a stroke frequency that scales with length-1, and second on observations that the speed of primarily air-breathing free-swimming animals, presumably swimming ‘efficiently’, is independent of size, confirming that stroke frequency scales as length-1. However, such scaling relations between size and swimming parameters for fish remain mostly theoretical. Based on free-swimming saithe and sturgeon tagged with accelerometers, we introduce a species-specific scaling relationship between dominant tail beat frequency (TBF) and fork length. Dominant TBF was proportional to length-1 (r2 = 0.73, n = 40), and estimated swimming speed within species was independent of length. Similar scaling relations accrued in relation to body mass-0.29. We demonstrate that the dominant TBF can be used to estimate size-at-time and that accelerometer tags with onboard processing may be able to provide size-at-time estimates among free-swimming fish and thus the estimation of growth rate (change in size-at-time) in the wild. PMID:26673777

Scaling in Free-Swimming Fish and Implications for Measuring Size-at-Time in the Wild.

Directory of Open Access Journals (Sweden)

Franziska Broell

Full Text Available This study was motivated by the need to measure size-at-age, and thus growth rate, in fish in the wild. We postulated that this could be achieved using accelerometer tags based first on early isometric scaling models that hypothesize that similar animals should move at the same speed with a stroke frequency that scales with length-1, and second on observations that the speed of primarily air-breathing free-swimming animals, presumably swimming 'efficiently', is independent of size, confirming that stroke frequency scales as length-1. However, such scaling relations between size and swimming parameters for fish remain mostly theoretical. Based on free-swimming saithe and sturgeon tagged with accelerometers, we introduce a species-specific scaling relationship between dominant tail beat frequency (TBF and fork length. Dominant TBF was proportional to length-1 (r2 = 0.73, n = 40, and estimated swimming speed within species was independent of length. Similar scaling relations accrued in relation to body mass-0.29. We demonstrate that the dominant TBF can be used to estimate size-at-time and that accelerometer tags with onboard processing may be able to provide size-at-time estimates among free-swimming fish and thus the estimation of growth rate (change in size-at-time in the wild.

US stock market efficiency over weekly, monthly, quarterly and yearly time scales

Science.gov (United States)

Rodriguez, E.; Aguilar-Cornejo, M.; Femat, R.; Alvarez-Ramirez, J.

2014-11-01

In financial markets, the weak form of the efficient market hypothesis implies that price returns are serially uncorrelated sequences. In other words, prices should follow a random walk behavior. Recent developments in evolutionary economic theory (Lo, 2004) have tailored the concept of adaptive market hypothesis (AMH) by proposing that market efficiency is not an all-or-none concept, but rather market efficiency is a characteristic that varies continuously over time and across markets. Within the AMH framework, this work considers the Dow Jones Index Average (DJIA) for studying the deviations from the random walk behavior over time. It is found that the market efficiency also varies over different time scales, from weeks to years. The well-known detrended fluctuation analysis was used for the characterization of the serial correlations of the return sequences. The results from the empirical showed that interday and intraday returns are more serially correlated than overnight returns. Also, some insights in the presence of business cycles (e.g., Juglar and Kuznets) are provided in terms of time variations of the scaling exponent.

Effects of forcing time scale on the simulated turbulent flows and turbulent collision statistics of inertial particles

International Nuclear Information System (INIS)

Rosa, B.; Parishani, H.; Ayala, O.; Wang, L.-P.

2015-01-01

In this paper, we study systematically the effects of forcing time scale in the large-scale stochastic forcing scheme of Eswaran and Pope [“An examination of forcing in direct numerical simulations of turbulence,” Comput. Fluids 16, 257 (1988)] on the simulated flow structures and statistics of forced turbulence. Using direct numerical simulations, we find that the forcing time scale affects the flow dissipation rate and flow Reynolds number. Other flow statistics can be predicted using the altered flow dissipation rate and flow Reynolds number, except when the forcing time scale is made unrealistically large to yield a Taylor microscale flow Reynolds number of 30 and less. We then study the effects of forcing time scale on the kinematic collision statistics of inertial particles. We show that the radial distribution function and the radial relative velocity may depend on the forcing time scale when it becomes comparable to the eddy turnover time. This dependence, however, can be largely explained in terms of altered flow Reynolds number and the changing range of flow length scales present in the turbulent flow. We argue that removing this dependence is important when studying the Reynolds number dependence of the turbulent collision statistics. The results are also compared to those based on a deterministic forcing scheme to better understand the role of large-scale forcing, relative to that of the small-scale turbulence, on turbulent collision of inertial particles. To further elucidate the correlation between the altered flow structures and dynamics of inertial particles, a conditional analysis has been performed, showing that the regions of higher collision rate of inertial particles are well correlated with the regions of lower vorticity. Regions of higher concentration of pairs at contact are found to be highly correlated with the region of high energy dissipation rate

Time-resolved transglottal pressure measurements in a scaled up vocal fold model

Science.gov (United States)

Ringenberg, Hunter; Krane, Michael; Rogers, Dylan; Misfeldt, Mitchel; Wei, Timothy

2016-11-01

Experimental measurements of flow through a scaled up dynamic human vocal fold model are presented. The simplified 10x scale vocal fold model from Krane, et al. (2007) was used to examine fundamental features of vocal fold oscillatory motion. Of particular interest was the temporal variation of transglottal pressure multiplied by the volume flow rate through the glottis throughout an oscillation cycle. Experiments were dynamically scaled to examine a range of frequencies, 100 - 200 Hz, corresponding to the male and female voice. By using water as the working fluid, very high resolution, both spatial and temporal resolution, was achieved. Time resolved movies of flow through symmetrically oscillating vocal folds will be presented. Both individual realizations as well as phase-averaged data will be shown. Key features, such as randomness and development time of the Coanda effect, vortex shedding, and volume flow rate data have been presented in previous APS-DFD meetings. This talk will focus more on the relation between the flow and aeroacoustics associated with vocal fold oscillations. Supported by the NIH.

Scaling of water vapor in the meso-gamma (2-20km) and lower meso-beta (20-50km) scales from tall tower time series

Science.gov (United States)

Pressel, K. G.; Collins, W.; Desai, A. R.

2011-12-01

Deficiencies in the parameterization of boundary layer clouds in global climate models (GCMs) remains one of the greatest sources of uncertainty in climate change predictions. Many GCM cloud parameterizations, which seek to include some representation of subgrid-scale cloud variability, do so by making assumptions regarding the subgrid-scale spatial probability density function (PDF) of total water content. Properly specifying the form and parameters of the total water PDF is an essential step in the formulation of PDF based cloud parameterizations. In the cloud free boundary layer, the PDF of total water mixing ratio is equivalent to the PDF of water vapor mixing ratio. Understanding the PDF of water vapor mixing ratio in the cloud free atmosphere is a necessary step towards understanding the PDF of water vapor in the cloudy atmosphere. A primary challenge in empirically constraining the PDF of water vapor mixing ratio is a distinct lack of a spatially distributed observational dataset at or near cloud scale. However, at meso-beta (20-50km) and larger scales, there is a wealth of information on the spatial distribution of water vapor contained in the physically retrieved water vapor profiles from the Atmospheric Infrared Sounder onboard NASA`s Aqua satellite. The scaling (scale-invariance) of the observed water vapor field has been suggested as means of using observations at satellite observed (meso-beta) scales to derive information about cloud scale PDFs. However, doing so requires the derivation of a robust climatology of water vapor scaling from in-situ observations across the meso- gamma (2-20km) and meso-beta scales. In this work, we present the results of the scaling of high frequency (10Hz) time series of water vapor mixing ratio as observed from the 447m WLEF tower located near Park Falls, Wisconsin. Observations from a tall tower offer an ideal set of observations with which to investigate scaling at meso-gamma and meso-beta scales requiring only the

Chaos anticontrol and synchronization of three time scales brushless DC motor system

International Nuclear Information System (INIS)

Ge Zhengming; Cheng Juiwen; Chen Yensheng

2004-01-01

Chaos anticontrol of three time scale brushless dc motors and chaos synchronization of different order systems are studied. Nondimensional dynamic equations of three time scale brushless DC motor system are presented. Using numerical results, such as phase diagram, bifurcation diagram, and Lyapunov exponent, periodic and chaotic motions can be observed. By adding constant term, periodic square wave, the periodic triangle wave, the periodic sawtooth wave, and kx vertical bar x vertical bar term, to achieve anticontrol of chaotic or periodic systems, it is found that more chaotic phenomena of the system can be observed. Then, by coupled terms and linearization of error dynamics, we obtain the partial synchronization of two different order systems, i.e. brushless DC motor system and rate gyroscope system

Evaluation of real-time operating system for small-scale embedded systems

International Nuclear Information System (INIS)

Dayang Norhayati Abang Jawawi; Rosbi Mamat

1999-01-01

In this paper, the performance of some real-time operating systems for small-scale embedded systems are evaluated based on some criteria. The evaluation is performed qualitatively and quantitatively. The evaluation results based on a case study on an engineering application will be presented. (author)

Correlated continuous time random walks: combining scale-invariance with long-range memory for spatial and temporal dynamics

International Nuclear Information System (INIS)

Schulz, Johannes H P; Chechkin, Aleksei V; Metzler, Ralf

2013-01-01

Standard continuous time random walk (CTRW) models are renewal processes in the sense that at each jump a new, independent pair of jump length and waiting time are chosen. Globally, anomalous diffusion emerges through scale-free forms of the jump length and/or waiting time distributions by virtue of the generalized central limit theorem. Here we present a modified version of recently proposed correlated CTRW processes, where we incorporate a power-law correlated noise on the level of both jump length and waiting time dynamics. We obtain a very general stochastic model, that encompasses key features of several paradigmatic models of anomalous diffusion: discontinuous, scale-free displacements as in Lévy flights, scale-free waiting times as in subdiffusive CTRWs, and the long-range temporal correlations of fractional Brownian motion (FBM). We derive the exact solutions for the single-time probability density functions and extract the scaling behaviours. Interestingly, we find that different combinations of the model parameters lead to indistinguishable shapes of the emerging probability density functions and identical scaling laws. Our model will be useful for describing recent experimental single particle tracking data that feature a combination of CTRW and FBM properties. (paper)

Mixing and flushing time scales in the Azhikode Estuary, southwest coast of India

Digital Repository Service at National Institute of Oceanography (India)

Revichandran, C.; Pylee, A.

Flushing time scales of the Azhikode Estuary, Kerala, India showed pronounced dry season and wet season signals as well as large inter-annual variation. Cumulative flushing time of the estuary varies from 4.8 tide cycles in April to 1.22 tide cycles...

Spatiotemporal patterns of drought at various time scales in Shandong Province of Eastern China

Science.gov (United States)

Zuo, Depeng; Cai, Siyang; Xu, Zongxue; Li, Fulin; Sun, Wenchao; Yang, Xiaojing; Kan, Guangyuan; Liu, Pin

2018-01-01

The temporal variations and spatial patterns of drought in Shandong Province of Eastern China were investigated by calculating the standardized precipitation evapotranspiration index (SPEI) at 1-, 3-, 6-, 12-, and 24-month time scales. Monthly precipitation and air temperature time series during the period 1960-2012 were collected at 23 meteorological stations uniformly distributed over the region. The non-parametric Mann-Kendall test was used to explore the temporal trends of precipitation, air temperature, and the SPEI drought index. S-mode principal component analysis (PCA) was applied to identify the spatial patterns of drought. The results showed that an insignificant decreasing trend in annual total precipitation was detected at most stations, a significant increase of annual average air temperature occurred at all the 23 stations, and a significant decreasing trend in the SPEI was mainly detected at the coastal stations for all the time scales. The frequency of occurrence of extreme and severe drought at different time scales generally increased with decades; higher frequency and larger affected area of extreme and severe droughts occurred as the time scale increased, especially for the northwest of Shandong Province and Jiaodong peninsular. The spatial pattern of drought for SPEI-1 contains three regions: eastern Jiaodong Peninsular and northwestern and southern Shandong. As the time scale increased to 3, 6, and 12 months, the order of the three regions was transformed into another as northwestern Shandong, eastern Jiaodong Peninsular, and southern Shandong. For SPEI-24, the location identified by REOF1 was slightly shifted from northwestern Shandong to western Shandong, and REOF2 and REOF3 identified another two weak patterns in the south edge and north edge of Jiaodong Peninsular, respectively. The potential causes of drought and the impact of drought on agriculture in the study area have also been discussed. The temporal variations and spatial patterns

Model based analysis of the time scales associated to pump start-ups

Energy Technology Data Exchange (ETDEWEB)

Dazin, Antoine, E-mail: antoine.dazin@lille.ensam.fr [Arts et métiers ParisTech/LML Laboratory UMR CNRS 8107, 8 bld Louis XIV, 59046 Lille cedex (France); Caignaert, Guy [Arts et métiers ParisTech/LML Laboratory UMR CNRS 8107, 8 bld Louis XIV, 59046 Lille cedex (France); Dauphin-Tanguy, Geneviève, E-mail: genevieve.dauphin-tanguy@ec-lille.fr [Univ Lille Nord de France, Ecole Centrale de Lille/CRISTAL UMR CNRS 9189, BP 48, 59651, Villeneuve d’Ascq cedex F 59000 (France)

2015-11-15

Highlights: • A dynamic model of a hydraulic system has been built. • Three periods in a pump start-up have been identified. • The time scales of each period have been estimated. • The parameters affecting the rapidity of a pump start-up have been explored. - Abstract: The paper refers to a non dimensional analysis of the behaviour of a hydraulic system during pump fast start-ups. The system is composed of a radial flow pump and its suction and delivery pipes. It is modelled using the bond graph methodology. The prediction of the model is validated by comparison to experimental results. An analysis of the time evolution of the terms acting on the total pump pressure is proposed. It allows for a decomposition of the start-up into three consecutive periods. The time scales associated with these periods are estimated. The effects of parameters (angular acceleration, final rotation speed, pipe length and resistance) affecting the start-up rapidity are then explored.

Intra- and inter-basin mercury comparisons: Importance of basin scale and time-weighted methylmercury estimates

International Nuclear Information System (INIS)

Bradley, Paul M.; Journey, Celeste A.; Brigham, Mark E.; Burns, Douglas A.; Button, Daniel T.; Riva-Murray, Karen

2013-01-01

To assess inter-comparability of fluvial mercury (Hg) observations at substantially different scales, Hg concentrations, yields, and bivariate-relations were evaluated at nested-basin locations in the Edisto River, South Carolina and Hudson River, New York. Differences between scales were observed for filtered methylmercury (FMeHg) in the Edisto (attributed to wetland coverage differences) but not in the Hudson. Total mercury (THg) concentrations and bivariate-relationships did not vary substantially with scale in either basin. Combining results of this and a previously published multi-basin study, fish Hg correlated strongly with sampled water FMeHg concentration (ρ = 0.78; p = 0.003) and annual FMeHg basin yield (ρ = 0.66; p = 0.026). Improved correlation (ρ = 0.88; p < 0.0001) was achieved with time-weighted mean annual FMeHg concentrations estimated from basin-specific LOADEST models and daily streamflow. Results suggest reasonable scalability and inter-comparability for different basin sizes if wetland area or related MeHg-source-area metrics are considered. - Highlights: ► National scale mercury assessments integrate small scale study results. ► Basin scale differences and representativeness of fluvial mercury samples are concerns. ► Wetland area, not basin size, predicts inter-basin methylmercury variability. ► Time-weighted methylmercury estimates improve the prediction of mercury in basin fish. - Fluvial methylmercury concentration correlates with wetland area not basin scale and time-weighted estimates better predict basin top predator mercury than discrete sample estimates.

Time scale defined by the fractal structure of the price fluctuations in foreign exchange markets

Science.gov (United States)

Kumagai, Yoshiaki

2010-04-01

In this contribution, a new time scale named C-fluctuation time is defined by price fluctuations observed at a given resolution. The intraday fractal structures and the relations of the three time scales: real time (physical time), tick time and C-fluctuation time, in foreign exchange markets are analyzed. The data set used is trading prices of foreign exchange rates; US dollar (USD)/Japanese yen (JPY), USD/Euro (EUR), and EUR/JPY. The accuracy of the data is one minute and data within a minute are recorded in order of transaction. The series of instantaneous velocity of C-fluctuation time flowing are exponentially distributed for small C when they are measured by real time and for tiny C when they are measured by tick time. When the market is volatile, for larger C, the series of instantaneous velocity are exponentially distributed.

A new time-space accounting scheme to predict stream water residence time and hydrograph source components at the watershed scale

Science.gov (United States)

Takahiro Sayama; Jeffrey J. McDonnell

2009-01-01

Hydrograph source components and stream water residence time are fundamental behavioral descriptors of watersheds but, as yet, are poorly represented in most rainfall-runoff models. We present a new time-space accounting scheme (T-SAS) to simulate the pre-event and event water fractions, mean residence time, and spatial source of streamflow at the watershed scale. We...

Multi-time-scale X-ray reverberation mapping of accreting black holes

Science.gov (United States)

Mastroserio, Guglielmo; Ingram, Adam; van der Klis, Michiel

2018-04-01

Accreting black holes show characteristic reflection features in their X-ray spectrum, including an iron Kα line, resulting from hard X-ray continuum photons illuminating the accretion disc. The reverberation lag resulting from the path-length difference between direct and reflected emission provides a powerful tool to probe the innermost regions around both stellar-mass and supermassive black holes. Here, we present for the first time a reverberation mapping formalism that enables modelling of energy-dependent time lags and variability amplitude for a wide range of variability time-scales, taking the complete information of the cross-spectrum into account. We use a pivoting power-law model to account for the spectral variability of the continuum that dominates over the reverberation lags for longer time-scale variability. We use an analytic approximation to self-consistently account for the non-linear effects caused by this continuum spectral variability, which have been ignored by all previous reverberation studies. We find that ignoring these non-linear effects can bias measurements of the reverberation lags, particularly at low frequencies. Since our model is analytic, we are able to fit simultaneously for a wide range of Fourier frequencies without prohibitive computational expense. We also introduce a formalism of fitting to real and imaginary parts of our cross-spectrum statistic, which naturally avoids some mistakes/inaccuracies previously common in the literature. We perform proof-of-principle fits to Rossi X-ray Timing Explorer data of Cygnus X-1.

Time delay effects on large-scale MR damper based semi-active control strategies

International Nuclear Information System (INIS)

Cha, Y-J; Agrawal, A K; Dyke, S J

2013-01-01

This paper presents a detailed investigation on the robustness of large-scale 200 kN MR damper based semi-active control strategies in the presence of time delays in the control system. Although the effects of time delay on stability and performance degradation of an actively controlled system have been investigated extensively by many researchers, degradation in the performance of semi-active systems due to time delay has yet to be investigated. Since semi-active systems are inherently stable, instability problems due to time delay are unlikely to arise. This paper investigates the effects of time delay on the performance of a building with a large-scale MR damper, using numerical simulations of near- and far-field earthquakes. The MR damper is considered to be controlled by four different semi-active control algorithms, namely (i) clipped-optimal control (COC), (ii) decentralized output feedback polynomial control (DOFPC), (iii) Lyapunov control, and (iv) simple-passive control (SPC). It is observed that all controllers except for the COC are significantly robust with respect to time delay. On the other hand, the clipped-optimal controller should be integrated with a compensator to improve the performance in the presence of time delay. (paper)

Incipient multiple fault diagnosis in real time with applications to large-scale systems

International Nuclear Information System (INIS)

Chung, H.Y.; Bien, Z.; Park, J.H.; Seon, P.H.

1994-01-01

By using a modified signed directed graph (SDG) together with the distributed artificial neutral networks and a knowledge-based system, a method of incipient multi-fault diagnosis is presented for large-scale physical systems with complex pipes and instrumentations such as valves, actuators, sensors, and controllers. The proposed method is designed so as to (1) make a real-time incipient fault diagnosis possible for large-scale systems, (2) perform the fault diagnosis not only in the steady-state case but also in the transient case as well by using a concept of fault propagation time, which is newly adopted in the SDG model, (3) provide with highly reliable diagnosis results and explanation capability of faults diagnosed as in an expert system, and (4) diagnose the pipe damage such as leaking, break, or throttling. This method is applied for diagnosis of a pressurizer in the Kori Nuclear Power Plant (NPP) unit 2 in Korea under a transient condition, and its result is reported to show satisfactory performance of the method for the incipient multi-fault diagnosis of such a large-scale system in a real-time manner

Analytical Solutions for Multi-Time Scale Fractional Stochastic Differential Equations Driven by Fractional Brownian Motion and Their Applications

OpenAIRE

Xiao-Li Ding; Juan J. Nieto

2018-01-01

In this paper, we investigate analytical solutions of multi-time scale fractional stochastic differential equations driven by fractional Brownian motions. We firstly decompose homogeneous multi-time scale fractional stochastic differential equations driven by fractional Brownian motions into independent differential subequations, and give their analytical solutions. Then, we use the variation of constant parameters to obtain the solutions of nonhomogeneous multi-time scale fractional stochast...

Decay of surface nanostructures via long-time-scale dynamics

International Nuclear Information System (INIS)

Voter, A.F.; Stanciu, N.

1998-01-01

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors have developed a new approach for extending the time scale of molecular dynamics simulations. For infrequent-event systems, the category that includes most diffusive events in the solid phase, this hyperdynamics method can extend the simulation time by a few orders of magnitude compared to direct molecular dynamics. The trajectory is run on a potential surface that has been biased to raise the energy in the potential basins without affecting the transition state region. The method is described and applied to surface and bulk diffusion processes, achieving microsecond and millisecond simulation times. The authors have also developed a new parallel computing method that is efficient for small system sizes. The combination of the hyperdynamics with this parallel replica dynamics looks promising as a general materials simulation tool

The Space-Time Conservative Schemes for Large-Scale, Time-Accurate Flow Simulations with Tetrahedral Meshes

Science.gov (United States)

Venkatachari, Balaji Shankar; Streett, Craig L.; Chang, Chau-Lyan; Friedlander, David J.; Wang, Xiao-Yen; Chang, Sin-Chung

2016-01-01

Despite decades of development of unstructured mesh methods, high-fidelity time-accurate simulations are still predominantly carried out on structured, or unstructured hexahedral meshes by using high-order finite-difference, weighted essentially non-oscillatory (WENO), or hybrid schemes formed by their combinations. In this work, the space-time conservation element solution element (CESE) method is used to simulate several flow problems including supersonic jet/shock interaction and its impact on launch vehicle acoustics, and direct numerical simulations of turbulent flows using tetrahedral meshes. This paper provides a status report for the continuing development of the space-time conservation element solution element (CESE) numerical and software framework under the Revolutionary Computational Aerosciences (RCA) project. Solution accuracy and large-scale parallel performance of the numerical framework is assessed with the goal of providing a viable paradigm for future high-fidelity flow physics simulations.

Cosmological special relativity the large scale structure of space, time and velocity

CERN Document Server

Carmeli, Moshe

1997-01-01

This book deals with special relativity theory and its application to cosmology. It presents Einstein's theory of space and time in detail, and describes the large scale structure of space, time and velocity as a new cosmological special relativity. A cosmological Lorentz-like transformation, which relates events at different cosmic times, is derived and applied. A new law of addition of cosmic times is obtained, and the inflation of the space at the early universe is derived, both from the cosmological transformation. The book will be of interest to cosmologists, astrophysicists, theoretical

Cosmological special relativity the large scale structure of space, time and velocity

CERN Document Server

Carmeli, Moshe

2002-01-01

This book presents Einstein's theory of space and time in detail, and describes the large-scale structure of space, time and velocity as a new cosmological special relativity. A cosmological Lorentz-like transformation, which relates events at different cosmic times, is derived and applied. A new law of addition of cosmic times is obtained, and the inflation of the space at the early universe is derived, both from the cosmological transformation. The relationship between cosmic velocity, acceleration and distances is given. In the appendices gravitation is added in the form of a cosmological g

Time scales for spinodal decomposition in nuclear matter with pseudoparticle models

International Nuclear Information System (INIS)

Idier, D.; Benhassine, B.; Farine, M.; Remaud, B.; Sebille, F.

1993-01-01

Dynamical instabilities arising from fluctuations in the spinodal zone for nuclear matter are studied using a large variety of zero range interactions in the frame of a pseudoparticle model. Scale times for spinodal decomposition are extracted and a possible link with decomposition in real heavy-ion collisions is discussed

Time scales for spinodal decomposition in nuclear matter with pseudoparticle models

Energy Technology Data Exchange (ETDEWEB)

Idier, D.; Benhassine, B.; Farine, M.; Remaud, B.; Sebille, F. (Laboratoire de Physique Nucleaire CNRS/IN2P3, Universite de Nantes, 2, rue de la Houssiniere, 44072 Nantes (France))

1993-08-01

Dynamical instabilities arising from fluctuations in the spinodal zone for nuclear matter are studied using a large variety of zero range interactions in the frame of a pseudoparticle model. Scale times for spinodal decomposition are extracted and a possible link with decomposition in real heavy-ion collisions is discussed.

Consensus for linear multi-agent system with intermittent information transmissions using the time-scale theory

Science.gov (United States)

Taousser, Fatima; Defoort, Michael; Djemai, Mohamed

2016-01-01

This paper investigates the consensus problem for linear multi-agent system with fixed communication topology in the presence of intermittent communication using the time-scale theory. Since each agent can only obtain relative local information intermittently, the proposed consensus algorithm is based on a discontinuous local interaction rule. The interaction among agents happens at a disjoint set of continuous-time intervals. The closed-loop multi-agent system can be represented using mixed linear continuous-time and linear discrete-time models due to intermittent information transmissions. The time-scale theory provides a powerful tool to combine continuous-time and discrete-time cases and study the consensus protocol under a unified framework. Using this theory, some conditions are derived to achieve exponential consensus under intermittent information transmissions. Simulations are performed to validate the theoretical results.

Multiple Positive Symmetric Solutions to p-Laplacian Dynamic Equations on Time Scales

Directory of Open Access Journals (Sweden)

You-Hui Su

2009-01-01

two examples are given to illustrate the main results and their differences. These results are even new for the special cases of continuous and discrete equations, as well as in the general time-scale setting.

Stepwise integral scaling method for severe accident analysis and its application to corium dispersion in direct containment heating

International Nuclear Information System (INIS)

Ishii, M.; Zhang, G.; No, H. C.; Eltwila, F.

1994-01-01

Accident sequences which lead to severe core damage and to possible radioactive fission products into the environment have a very low probability. However, the interest in this area increased significantly due to the occurrence of the small break loss-of-coolant accident at TMI-2 which led to partial core damage, and of the Chernobyl accident in the former USSR which led to extensive core disassembly and significant release of fission products over several countries. In particular, the latter accident raised the international concern over the potential consequences of severe accidents in nuclear reactor systems. One of the significant shortcomings in the analyses of severe accidents is the lack of well-established and reliable scaling criteria for various multiphase flow phenomena. However, the scaling criteria are essential to the severe accident, because the full scale tests are basically impossible to perform. They are required for (1) designing scaled down or simulation experiments, (2) evaluating data and extrapolating the data to prototypic conditions, and (3) developing correctly scaled physical models and correlations. In view of this, a new scaling method is developed for the analysis of severe accidents. Its approach is quite different from the conventional methods. In order to demonstrate its applicability, this new stepwise integral scaling method has been applied to the analysis of the corium dispersion problem in the direct containment heating. ((orig.))

Scaling of the first-passage time of biased diffusion on hierarchical comb structures

International Nuclear Information System (INIS)

Lin Zhifang; Tao Ruibao.

1989-12-01

Biased diffusion on hierarchical comb structures is studied within an exact renormalization group scheme. The scaling exponents of the moments of the first-passage time for random walks are obtained. It is found that the scaling properties of the diffusion depend only on the direction of bias. In this particular case, the presence of bias may give rise to a new multifractality. (author). 7 refs, 2 figs

Correcting Spatial Variance of RCM for GEO SAR Imaging Based on Time-Frequency Scaling

Science.gov (United States)

Yu, Ze; Lin, Peng; Xiao, Peng; Kang, Lihong; Li, Chunsheng

2016-01-01

Compared with low-Earth orbit synthetic aperture radar (SAR), a geosynchronous (GEO) SAR can have a shorter revisit period and vaster coverage. However, relative motion between this SAR and targets is more complicated, which makes range cell migration (RCM) spatially variant along both range and azimuth. As a result, efficient and precise imaging becomes difficult. This paper analyzes and models spatial variance for GEO SAR in the time and frequency domains. A novel algorithm for GEO SAR imaging with a resolution of 2 m in both the ground cross-range and range directions is proposed, which is composed of five steps. The first is to eliminate linear azimuth variance through the first azimuth time scaling. The second is to achieve RCM correction and range compression. The third is to correct residual azimuth variance by the second azimuth time-frequency scaling. The fourth and final steps are to accomplish azimuth focusing and correct geometric distortion. The most important innovation of this algorithm is implementation of the time-frequency scaling to correct high-order azimuth variance. As demonstrated by simulation results, this algorithm can accomplish GEO SAR imaging with good and uniform imaging quality over the entire swath. PMID:27428974

Climatic changes on orbital and sub-orbital time scale recorded by the Guliya ice core in Tibetan Plateau

Institute of Scientific and Technical Information of China (English)

姚檀栋; 徐柏青; 蒲健辰

2001-01-01

Based on ice core records in the Tibetan Plateau and Greenland, the features and possible causes of climatic changes on orbital and sub-orbital time scale were discussed. Orbital time scale climatic change recorded in ice core from the Tibetan Plateau is typically ahead of that from polar regions, which indicates that climatic change in the Tibetan Plateau might be earlier than polar regions. The solar radiation change is a major factor that dominates the climatic change on orbital time scale. However, climatic events on sub-orbital time scale occurred later in the Tibetan Plateau than in the Arctic Region, indicating a different mechanism. For example, the Younger Dryas and Heinrich events took place earlier in Greenland ice core record than in Guliya ice core record. It is reasonable to propose the hypothesis that these climatic events were affected possibly by the Laurentide Ice Sheet. Therefore, ice sheet is critically important to climatic change on sub-orbital time scale in some ice ages.

Sensitivity of the breastfeeding motivational measurement scale: a known group analysis of first time mothers.

Science.gov (United States)

Stockdale, Janine; Sinclair, Marlene; Kernohan, George; McCrum-Gardner, Evie; Keller, John

2013-01-01

Breastfeeding has immense public health value for mothers, babies, and society. But there is an undesirably large gap between the number of new mothers who undertake and persist in breastfeeding compared to what would be a preferred level of accomplishment. This gap is a reflection of the many obstacles, both physical and psychological, that confront new mothers. Previous research has illuminated many of these concerns, but research on this problem is limited in part by the unavailability of a research instrument that can measure the key differences between first-time mothers and experienced mothers, with regard to the challenges they face when breastfeeding and the instructional advice they require. An instrument was designed to measure motivational complexity associated with sustained breast feeding behaviour; the Breastfeeding Motivational Measurement Scale. It contains 51 self-report items (7 point Likert scale) that cluster into four categories related to perceived value of breast-feeding, confidence to succeed, factors that influence success or failure, and strength of intentions, or goal. However, this scale has not been validated in terms of its sensitivity to profile the motivation of new mothers and experienced mothers. This issue was investigated by having 202 breastfeeding mothers (100 first time mothers) fill out the scale. The analysis reported in this paper is a three factor solution consisting of value, midwife support, and expectancies for success that explained the characteristics of first time mothers as a known group. These results support the validity of the BMM scale as a diagnostic tool for research on first time mothers who are learning to breastfeed. Further research studies are required to further test the validity of the scale in additional subgroups.

A limit set trichotomy for order-preserving systems on time scales

Directory of Open Access Journals (Sweden)

Christian Poetzsche

2004-04-01

Full Text Available In this paper we derive a limit set trichotomy for abstract order-preserving 2-parameter semiflows in normal cones of strongly ordered Banach spaces. Additionally, to provide an example, Muller's theorem is generalized to dynamic equations on arbitrary time scales and applied to a model from population dynamics.

How the constants in Hille-Nehari theorems depend on time scales

Czech Academy of Sciences Publication Activity Database

Řehák, Pavel

2006-01-01

Roč. 2006, - (2006), s. 1-15 ISSN 1687-1839 R&D Pro jects: GA ČR(CZ) GA201/01/0079; GA ČR(CZ) GP201/01/P041 Institutional research plan: CEZ:AV0Z10190503 Keywords : dynamic equation * time scales * oscillation criteria Subject RIV: BA - General Mathematics

Multi-scale simulations of droplets in generic time-dependent flows

Science.gov (United States)

Milan, Felix; Biferale, Luca; Sbragaglia, Mauro; Toschi, Federico

2017-11-01

We study the deformation and dynamics of droplets in time-dependent flows using a diffuse interface model for two immiscible fluids. The numerical simulations are at first benchmarked against analytical results of steady droplet deformation, and further extended to the more interesting case of time-dependent flows. The results of these time-dependent numerical simulations are compared against analytical models available in the literature, which assume the droplet shape to be an ellipsoid at all times, with time-dependent major and minor axis. In particular we investigate the time-dependent deformation of a confined droplet in an oscillating Couette flow for the entire capillary range until droplet break-up. In this way these multi component simulations prove to be a useful tool to establish from ``first principles'' the dynamics of droplets in complex flows involving multiple scales. European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No 642069. & European Research Council under the European Community's Seventh Framework Program, ERC Grant Agreement No 339032.

OSCILLATION CRITERIA FOR A FOURTH ORDER SUBLINEAR DYNAMIC EQUATION ON TIME SCALE

Institute of Scientific and Technical Information of China (English)

无

2011-01-01

Some new criteria for the oscillation of a fourth order sublinear and/or linear dynamic equation on time scale are established. Our results are new for the corresponding fourth order differential equations as well as difference equations.

Time-scales for runoff and erosion estimates, with implications for spatial scaling

Science.gov (United States)

Kirkby, M. J.; Irvine, B. J.; Dalen, E. N.

2009-04-01

Using rainfall data at high temporal resolution, runoff may be estimated for every bucket-tip, or for aggregated hourly or daily periods. Although there is no doubt that finer resolution gives substantially better estimates, many models make use of coarser time steps because these data are more widely available. This paper makes comparisons between runoff estimates based on infiltration measurements used with high resolution rainfall data for SE Spain and theoretical work on improving the time resolution in the PESERA model from daily to hourly values, for areas where these are available. For a small plot at fine temporal scale, runoff responds to bursts of intense rainfall which, for the Guadalentin catchment, typically lasts for about 30 minutes. However, when a larger area is considered, the large and unstructured variability in infiltration capacity produces an aggregate runoff that differs substantially from estimates using average infiltration parameters (in the Green-Ampt equation). When these estimates are compared with estimates based on rainfall for aggregated hourly or daily periods, using a simpler infiltration model, it can be seen that there a substantial scatter, as expected, but that suitable parameterisation can provide reasonable average estimates. Similar conclusions may be drawn for erosion estimates, assuming that sediment transport is proportional to a power of runoff discharge.. The spatial implications of these estimates can be made explicit with fine time resolution, showing that, with observed low overland flow velocities, only a small fraction of the hillside is generally able to deliver runoff to the nearest channel before rainfall intensity drops and runoff re-infiltrates. For coarser time resolutions, this has to be parameterised as a delivery ratio, and we show that how this ratio can be rationally estimated from rainfall characteristics.

Tracking and visualization of space-time activities for a micro-scale flu transmission study.

Science.gov (United States)

Qi, Feng; Du, Fei

2013-02-07

Infectious diseases pose increasing threats to public health with increasing population density and more and more sophisticated social networks. While efforts continue in studying the large scale dissemination of contagious diseases, individual-based activity and behaviour study benefits not only disease transmission modelling but also the control, containment, and prevention decision making at the local scale. The potential for using tracking technologies to capture detailed space-time trajectories and model individual behaviour is increasing rapidly, as technological advances enable the manufacture of small, lightweight, highly sensitive, and affordable receivers and the routine use of location-aware devices has become widespread (e.g., smart cellular phones). The use of low-cost tracking devices in medical research has also been proved effective by more and more studies. This study describes the use of tracking devices to collect data of space-time trajectories and the spatiotemporal processing of such data to facilitate micro-scale flu transmission study. We also reports preliminary findings on activity patterns related to chances of influenza infection in a pilot study. Specifically, this study employed A-GPS tracking devices to collect data on a university campus. Spatiotemporal processing was conducted for data cleaning and segmentation. Processed data was validated with traditional activity diaries. The A-GPS data set was then used for visual explorations including density surface visualization and connection analysis to examine space-time activity patterns in relation to chances of influenza infection. When compared to diary data, the segmented tracking data demonstrated to be an effective alternative and showed greater accuracies in time as well as the details of routes taken by participants. A comparison of space-time activity patterns between participants who caught seasonal influenza and those who did not revealed interesting patterns. This study

Study of fission time scale from measurement of pre-scission light particle and γ-ray multiplicities

International Nuclear Information System (INIS)

Ramachandran, K.; Chatterjee, A.; Navin, A.

2014-01-01

This work presents the result of a simultaneous measurement of pre-scission multiplicities and analysis using the statistical model code JOANNE2 which includes deformation effects. Evaporation residue cross-sections has also been measured for the same system and analyzed in a consistent manner. The neutron, charged particle, GDR γ-ray and ER data could be explained consistently. The emission of neutrons seems to be favored towards larger deformation as compared to charged particles. The pre-scission time scale is deduced as 0-2 x 10 -21 s whereas the saddle-to-scission time scale is 36-39 x 10 -21 s. The total fission time scale is deduced as 36-41 x 10 -21 s

Attractors of relaxation discrete-time systems with chaotic dynamics on a fast time scale

International Nuclear Information System (INIS)

Maslennikov, Oleg V.; Nekorkin, Vladimir I.

2016-01-01

In this work, a new type of relaxation systems is considered. Their prominent feature is that they comprise two distinct epochs, one is slow regular motion and another is fast chaotic motion. Unlike traditionally studied slow-fast systems that have smooth manifolds of slow motions in the phase space and fast trajectories between them, in this new type one observes, apart the same geometric objects, areas of transient chaos. Alternating periods of slow regular motions and fast chaotic ones as well as transitions between them result in a specific chaotic attractor with chaos on a fast time scale. We formulate basic properties of such attractors in the framework of discrete-time systems and consider several examples. Finally, we provide an important application of such systems, the neuronal electrical activity in the form of chaotic spike-burst oscillations.

Correlated continuous-time random walks—scaling limits and Langevin picture

International Nuclear Information System (INIS)

Magdziarz, Marcin; Metzler, Ralf; Szczotka, Wladyslaw; Zebrowski, Piotr

2012-01-01

In this paper we analyze correlated continuous-time random walks introduced recently by Tejedor and Metzler (2010 J. Phys. A: Math. Theor. 43 082002). We obtain the Langevin equations associated with this process and the corresponding scaling limits of their solutions. We prove that the limit processes are self-similar and display anomalous dynamics. Moreover, we extend the model to include external forces. Our results are confirmed by Monte Carlo simulations

Analysis of passive scalar advection in parallel shear flows: Sorting of modes at intermediate time scales

Science.gov (United States)

Camassa, Roberto; McLaughlin, Richard M.; Viotti, Claudio

2010-11-01

The time evolution of a passive scalar advected by parallel shear flows is studied for a class of rapidly varying initial data. Such situations are of practical importance in a wide range of applications from microfluidics to geophysics. In these contexts, it is well-known that the long-time evolution of the tracer concentration is governed by Taylor's asymptotic theory of dispersion. In contrast, we focus here on the evolution of the tracer at intermediate time scales. We show how intermediate regimes can be identified before Taylor's, and in particular, how the Taylor regime can be delayed indefinitely by properly manufactured initial data. A complete characterization of the sorting of these time scales and their associated spatial structures is presented. These analytical predictions are compared with highly resolved numerical simulations. Specifically, this comparison is carried out for the case of periodic variations in the streamwise direction on the short scale with envelope modulations on the long scales, and show how this structure can lead to "anomalously" diffusive transients in the evolution of the scalar onto the ultimate regime governed by Taylor dispersion. Mathematically, the occurrence of these transients can be viewed as a competition in the asymptotic dominance between large Péclet (Pe) numbers and the long/short scale aspect ratios (LVel/LTracer≡k), two independent nondimensional parameters of the problem. We provide analytical predictions of the associated time scales by a modal analysis of the eigenvalue problem arising in the separation of variables of the governing advection-diffusion equation. The anomalous time scale in the asymptotic limit of large k Pe is derived for the short scale periodic structure of the scalar's initial data, for both exactly solvable cases and in general with WKBJ analysis. In particular, the exactly solvable sawtooth flow is especially important in that it provides a short cut to the exact solution to the

Real-Time Monitoring System for a Utility-Scale Photovoltaic Power Plant.

Science.gov (United States)

Moreno-Garcia, Isabel M; Palacios-Garcia, Emilio J; Pallares-Lopez, Victor; Santiago, Isabel; Gonzalez-Redondo, Miguel J; Varo-Martinez, Marta; Real-Calvo, Rafael J

2016-05-26

There is, at present, considerable interest in the storage and dispatchability of photovoltaic (PV) energy, together with the need to manage power flows in real-time. This paper presents a new system, PV-on time, which has been developed to supervise the operating mode of a Grid-Connected Utility-Scale PV Power Plant in order to ensure the reliability and continuity of its supply. This system presents an architecture of acquisition devices, including wireless sensors distributed around the plant, which measure the required information. It is also equipped with a high-precision protocol for synchronizing all data acquisition equipment, something that is necessary for correctly establishing relationships among events in the plant. Moreover, a system for monitoring and supervising all of the distributed devices, as well as for the real-time treatment of all the registered information, is presented. Performances were analyzed in a 400 kW transformation center belonging to a 6.1 MW Utility-Scale PV Power Plant. In addition to monitoring the performance of all of the PV plant's components and detecting any failures or deviations in production, this system enables users to control the power quality of the signal injected and the influence of the installation on the distribution grid.

Real-Time Monitoring System for a Utility-Scale Photovoltaic Power Plant

Science.gov (United States)

Moreno-Garcia, Isabel M.; Palacios-Garcia, Emilio J.; Pallares-Lopez, Victor; Santiago, Isabel; Gonzalez-Redondo, Miguel J.; Varo-Martinez, Marta; Real-Calvo, Rafael J.

2016-01-01

There is, at present, considerable interest in the storage and dispatchability of photovoltaic (PV) energy, together with the need to manage power flows in real-time. This paper presents a new system, PV-on time, which has been developed to supervise the operating mode of a Grid-Connected Utility-Scale PV Power Plant in order to ensure the reliability and continuity of its supply. This system presents an architecture of acquisition devices, including wireless sensors distributed around the plant, which measure the required information. It is also equipped with a high-precision protocol for synchronizing all data acquisition equipment, something that is necessary for correctly establishing relationships among events in the plant. Moreover, a system for monitoring and supervising all of the distributed devices, as well as for the real-time treatment of all the registered information, is presented. Performances were analyzed in a 400 kW transformation center belonging to a 6.1 MW Utility-Scale PV Power Plant. In addition to monitoring the performance of all of the PV plant’s components and detecting any failures or deviations in production, this system enables users to control the power quality of the signal injected and the influence of the installation on the distribution grid. PMID:27240365

Real-Time Monitoring System for a Utility-Scale Photovoltaic Power Plant

Directory of Open Access Journals (Sweden)

Isabel M. Moreno-Garcia

2016-05-01

Full Text Available There is, at present, considerable interest in the storage and dispatchability of photovoltaic (PV energy, together with the need to manage power flows in real-time. This paper presents a new system, PV-on time, which has been developed to supervise the operating mode of a Grid-Connected Utility-Scale PV Power Plant in order to ensure the reliability and continuity of its supply. This system presents an architecture of acquisition devices, including wireless sensors distributed around the plant, which measure the required information. It is also equipped with a high-precision protocol for synchronizing all data acquisition equipment, something that is necessary for correctly establishing relationships among events in the plant. Moreover, a system for monitoring and supervising all of the distributed devices, as well as for the real-time treatment of all the registered information, is presented. Performances were analyzed in a 400 kW transformation center belonging to a 6.1 MW Utility-Scale PV Power Plant. In addition to monitoring the performance of all of the PV plant’s components and detecting any failures or deviations in production, this system enables users to control the power quality of the signal injected and the influence of the installation on the distribution grid.

Development and Preliminary Validation of the Time Management for Exercise Scale

Science.gov (United States)

Hellsten, Laurie-ann M.; Rogers, W. Todd

2009-01-01

The purpose of this study was to collect preliminary validity evidence for a time management scale for exercise. An initial pool of 91 items was developed from existing literature. Ten exercise/health psychologists evaluated each of the items in terms of relevance and representativeness. Forty-nine items met all criteria. Exploratory factor…

Multiple time-scale methods in particle simulations of plasmas

International Nuclear Information System (INIS)

Cohen, B.I.

1985-01-01

This paper surveys recent advances in the application of multiple time-scale methods to particle simulation of collective phenomena in plasmas. These methods dramatically improve the efficiency of simulating low-frequency kinetic behavior by allowing the use of a large timestep, while retaining accuracy. The numerical schemes surveyed provide selective damping of unwanted high-frequency waves and preserve numerical stability in a variety of physics models: electrostatic, magneto-inductive, Darwin and fully electromagnetic. The paper reviews hybrid simulation models, the implicitmoment-equation method, the direct implicit method, orbit averaging, and subcycling

Modes of correlated angular motion in live cells across three distinct time scales

International Nuclear Information System (INIS)

Harrison, Andrew W; Kenwright, David A; Woodman, Philip G; Allan, Victoria J; Waigh, Thomas A

2013-01-01

Particle tracking experiments with high speed digital microscopy yield the positions and trajectories of lipid droplets inside living cells. Angular correlation analysis shows that the lipid droplets have uncorrelated motion at short time scales (τ 10 ms, becomes persistent, indicating directed movement. The motion at all time scales is associated with the lipid droplets being tethered to and driven along the microtubule network. The point at which the angular correlation changes from anti-persistent to persistent motion corresponds to the cross over between sub-diffusive and super diffusive motion, as observed by mean square displacement analysis. Correct analysis of the angular correlations of the detector noise is found to be crucial in modelling the observed phenomena. (paper)

Linking Time and Space Scales in Distributed Hydrological Modelling - a case study for the VIC model

Science.gov (United States)

Melsen, Lieke; Teuling, Adriaan; Torfs, Paul; Zappa, Massimiliano; Mizukami, Naoki; Clark, Martyn; Uijlenhoet, Remko

2015-04-01

One of the famous paradoxes of the Greek philosopher Zeno of Elea (~450 BC) is the one with the arrow: If one shoots an arrow, and cuts its motion into such small time steps that at every step the arrow is standing still, the arrow is motionless, because a concatenation of non-moving parts does not create motion. Nowadays, this reasoning can be refuted easily, because we know that motion is a change in space over time, which thus by definition depends on both time and space. If one disregards time by cutting it into infinite small steps, motion is also excluded. This example shows that time and space are linked and therefore hard to evaluate separately. As hydrologists we want to understand and predict the motion of water, which means we have to look both in space and in time. In hydrological models we can account for space by using spatially explicit models. With increasing computational power and increased data availability from e.g. satellites, it has become easier to apply models at a higher spatial resolution. Increasing the resolution of hydrological models is also labelled as one of the 'Grand Challenges' in hydrology by Wood et al. (2011) and Bierkens et al. (2014), who call for global modelling at hyperresolution (~1 km and smaller). A literature survey on 242 peer-viewed articles in which the Variable Infiltration Capacity (VIC) model was used, showed that the spatial resolution at which the model is applied has decreased over the past 17 years: From 0.5 to 2 degrees when the model was just developed, to 1/8 and even 1/32 degree nowadays. On the other hand the literature survey showed that the time step at which the model is calibrated and/or validated remained the same over the last 17 years; mainly daily or monthly. Klemeš (1983) stresses the fact that space and time scales are connected, and therefore downscaling the spatial scale would also imply downscaling of the temporal scale. Is it worth the effort of downscaling your model from 1 degree to 1

A rainfall disaggregation scheme for sub-hourly time scales: Coupling a Bartlett-Lewis based model with adjusting procedures

Science.gov (United States)

Kossieris, Panagiotis; Makropoulos, Christos; Onof, Christian; Koutsoyiannis, Demetris

2018-01-01

Many hydrological applications, such as flood studies, require the use of long rainfall data at fine time scales varying from daily down to 1 min time step. However, in the real world there is limited availability of data at sub-hourly scales. To cope with this issue, stochastic disaggregation techniques are typically employed to produce possible, statistically consistent, rainfall events that aggregate up to the field data collected at coarser scales. A methodology for the stochastic disaggregation of rainfall at fine time scales was recently introduced, combining the Bartlett-Lewis process to generate rainfall events along with adjusting procedures to modify the lower-level variables (i.e., hourly) so as to be consistent with the higher-level one (i.e., daily). In the present paper, we extend the aforementioned scheme, initially designed and tested for the disaggregation of daily rainfall into hourly depths, for any sub-hourly time scale. In addition, we take advantage of the recent developments in Poisson-cluster processes incorporating in the methodology a Bartlett-Lewis model variant that introduces dependence between cell intensity and duration in order to capture the variability of rainfall at sub-hourly time scales. The disaggregation scheme is implemented in an R package, named HyetosMinute, to support disaggregation from daily down to 1-min time scale. The applicability of the methodology was assessed on a 5-min rainfall records collected in Bochum, Germany, comparing the performance of the above mentioned model variant against the original Bartlett-Lewis process (non-random with 5 parameters). The analysis shows that the disaggregation process reproduces adequately the most important statistical characteristics of rainfall at wide range of time scales, while the introduction of the model with dependent intensity-duration results in a better performance in terms of skewness, rainfall extremes and dry proportions.

Measuring parent time scarcity and fatigue as barriers to meal planning and preparation: quantitative scale development.

Science.gov (United States)

Storfer-Isser, Amy; Musher-Eizenman, Dara

2013-03-01

To examine the psychometric properties of 9 quantitative items that assess time scarcity and fatigue as parent barriers to planning and preparing meals for their children. A convenience sample of 342 parents of children aged 2-6 years completed a 20-minute online survey. Exploratory factor analysis was used to examine the factor structure and create summary scales. Internal consistency reliability and measures of construct and concurrent validity were assessed. Two scales were created based on the factor analysis: time and energy for meals and meal planning. Preliminary evidence suggests that both scales are reliable and valid. The time and energy for meals and meal planning scales can be completed quickly by busy and tired parents. As many children do not eat nutritious diets, a better understanding of the barriers that parents face is critical and may help inform interventions tailored to the needs of tired, busy parents. Copyright © 2013 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

In-silico experiments on characteristic time scale at a shear-free gas-liquid interface in fully developed turbulence

International Nuclear Information System (INIS)

Nagaosa, Ryuichi; Handler, Robert A

2011-01-01

The purpose of this study is to model scalar transfer mechanisms in a fully developed turbulence for accurate predictions of the turbulent scalar flux across a shear-free gas-liquid interface. The concept of the surface-renewal approximation (Dankwerts, 1951) is introduced in this study to establish the predictive models for the interfacial scalar flux. Turbulent flow realizations obtained by a direct numerical simulation technique are employed to prepare details of three-dimensional information on turbulence in the region very close to the interface. Two characteristic time scales at the interface have been examined for exact prediction of the scalar transfer flux. One is the time scale which is reciprocal of the root-mean-square surface divergence, T γ = (γγ) −1/2 , where γ is the surface divergence. The other time scale to be examined is T S = Λ/V, where Λ is the zero-correlation length of the surface divergence as the interfacial length scale, and V is the root-mean-square velocity fluctuation in the streamwise direction as the interfacial velocity scale. The results of this study suggests that T γ is slightly unsatisfactory to correlate the turbulent scalar flux at the gas-liquid interface based on the surface-renewal approximation. It is also found that the proportionality constant appear to be 0.19, which is different with that observed in the laboratory experiments, 0.34 (Komori, Murakami, and Ueda, 1989). It is concluded that the time scale, T γ , is considered a different kind of the time scale observed in the laboratory experiments. On the other hand, the present in-silico experiments indicate that T s predicts the turbulent scalar flux based on the surface-renewal approximation in a satisfactory manner. It is also elucidated that the proportionality constant for T s is approximately 0.36, which is very close to that found by the laboratory experiments. This fact shows that the time scale T s appears to be essentially the same as the time scale

In-silico experiments on characteristic time scale at a shear-free gas-liquid interface in fully developed turbulence

Energy Technology Data Exchange (ETDEWEB)

Nagaosa, Ryuichi [Research Center for Compact Chemical System (CCS), AIST, 4-2-1 Nigatake, Miyagino, Sendai 983-8551 (Japan); Handler, Robert A, E-mail: ryuichi.nagaosa@aist.go.jp [Department of Mechanical Engineering, Texas A and M University, College Station, TX 77843-3123 (United States)

2011-12-22

The purpose of this study is to model scalar transfer mechanisms in a fully developed turbulence for accurate predictions of the turbulent scalar flux across a shear-free gas-liquid interface. The concept of the surface-renewal approximation (Dankwerts, 1951) is introduced in this study to establish the predictive models for the interfacial scalar flux. Turbulent flow realizations obtained by a direct numerical simulation technique are employed to prepare details of three-dimensional information on turbulence in the region very close to the interface. Two characteristic time scales at the interface have been examined for exact prediction of the scalar transfer flux. One is the time scale which is reciprocal of the root-mean-square surface divergence, T{sub {gamma}} = ({gamma}{gamma}){sup -1/2}, where {gamma} is the surface divergence. The other time scale to be examined is T{sub S} = {Lambda}/V, where {Lambda} is the zero-correlation length of the surface divergence as the interfacial length scale, and V is the root-mean-square velocity fluctuation in the streamwise direction as the interfacial velocity scale. The results of this study suggests that T{sub {gamma}} is slightly unsatisfactory to correlate the turbulent scalar flux at the gas-liquid interface based on the surface-renewal approximation. It is also found that the proportionality constant appear to be 0.19, which is different with that observed in the laboratory experiments, 0.34 (Komori, Murakami, and Ueda, 1989). It is concluded that the time scale, T{sub {gamma}}, is considered a different kind of the time scale observed in the laboratory experiments. On the other hand, the present in-silico experiments indicate that T{sub s} predicts the turbulent scalar flux based on the surface-renewal approximation in a satisfactory manner. It is also elucidated that the proportionality constant for T{sub s} is approximately 0.36, which is very close to that found by the laboratory experiments. This fact shows

Time-scale and extent at which large-scale circulation modes determine the wind and solar potential in the Iberian Peninsula

International Nuclear Information System (INIS)

Jerez, Sonia; Trigo, Ricardo M

2013-01-01

The North Atlantic Oscillation (NAO), the East Atlantic (EA) and the Scandinavian (SCAND) modes are the three main large-scale circulation patterns driving the climate variability of the Iberian Peninsula. This study assesses their influence in terms of solar (photovoltaic) and wind power generation potential (SP and WP) and evaluates their skill as predictors. For that we use a hindcast regional climate simulation to retrieve the primary meteorological variables involved, surface solar radiation and wind speed. First we identify that the maximum influence of the various modes occurs on the interannual variations of the monthly mean SP and WP series, being generally more relevant in winter. Second we find that in this time-scale and season, SP (WP) varies up to 30% (40%) with respect to the mean climatology between years with opposite phases of the modes, although the strength and the spatial distribution of the signals differ from one month to another. Last, the skill of a multi-linear regression model (MLRM), built using the NAO, EA and SCAND indices, to reconstruct the original wintertime monthly series of SP and WP was investigated. The reconstructed series (when the MLRM is calibrated for each month individually) correlate with the original ones up to 0.8 at the interannual time-scale. Besides, when the modeled series for each individual month are merged to construct an October-to-March monthly series, and after removing the annual cycle in order to account for monthly anomalies, these correlate 0.65 (0.55) with the original SP (WP) series in average. These values remain fairly stable when the calibration and reconstruction periods differ, thus supporting up to a point the predictive potential of the method at the time-scale assessed here. (letter)

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.

Science.gov (United States)

Hanna, Michael G; Block, Samuel; Frankel, E B; Hou, Feng; Johnson, Adam; Yuan, Lin; Knight, Gavin; Moresco, James J; Yates, John R; Ashton, Randolph; Schekman, Randy; Tong, Yufeng; Audhya, Anjon

2017-09-12

The conserved coat protein complex II (COPII) mediates the initial steps of secretory protein trafficking by assembling onto subdomains of the endoplasmic reticulum (ER) in two layers to generate cargo-laden transport carriers that ultimately fuse with an adjacent ER-Golgi intermediate compartment (ERGIC). Here, we demonstrate that Trk-fused gene (TFG) binds directly to the inner layer of the COPII coat. Specifically, the TFG C terminus interacts with Sec23 through a shared interface with the outer COPII coat and the cargo receptor Tango1/cTAGE5. Our findings indicate that TFG binding to Sec23 outcompetes these other associations in a concentration-dependent manner and ultimately promotes outer coat dissociation. Additionally, we demonstrate that TFG tethers vesicles harboring the inner COPII coat, which contributes to their clustering between the ER and ERGIC in cells. Together, our studies define a mechanism by which COPII transport carriers are retained locally at the ER/ERGIC interface after outer coat disassembly, which is a prerequisite for fusion with ERGIC membranes.

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

Directory of Open Access Journals (Sweden)

Lynsey Vaughan

2015-01-01

Full Text Available The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM1 ubiquitylation and degradation predominantly at cell-cell adhesions, facilitating junction disassembly, migration, and invasion. Depleting HUWE1 or mutating the TIAM1 ubiquitylation site prevents TIAM1 degradation, antagonizing scattering, and invasion. Moreover, simultaneous depletion of TIAM1 restores migration and invasion in HUWE1-depleted cells. Significantly, we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 stability. Finally, we demonstrate that HUWE1 and TIAM1 protein levels are inversely correlated in human lung carcinomas. Thus, we elucidate a critical role for HUWE1 in regulating epithelial cell-cell adhesion and provide additional evidence that ubiquitylation contributes to spatiotemporal control of RAC.

Time scaling internal state predictive control of a solar plant

Energy Technology Data Exchange (ETDEWEB)

Silva, R.N. [DEE-FCT/UNL, Caparica (Portugal); Rato, L.M. [INESC-ID/University, Evora (Portugal); Lemos, J.M. [INESC-ID/IST, Lisboa (Portugal)

2003-12-01

The control of a distributed collector solar field is addressed in this work, exploiting the plant's transport characteristic. The plant is modeled by a hyperbolic type partial differential equation (PDE) where the transport speed is the manipulated flow, i.e. the controller output. The model has an external distributed source, which is the solar radiation captured along the collector, approximated to depend only of time. From the solution of the PDE, a linear discrete state space model is obtained by using time-scaling and the redefinition of the control input. This method allows overcoming the dependency of the time constants with the operating point. A model-based predictive adaptive controller is derived with the internal temperature distribution estimated with a state observer. Experimental results at the solar power plant are presented, illustrating the advantages of the approach under consideration. (author)

New Bounds of Ostrowski–Gruss Type Inequality for (k + 1 Points on Time Scales

Directory of Open Access Journals (Sweden)

Eze R. Nwaeze

2017-11-01

Full Text Available The aim of this paper is to present three new bounds of the Ostrowski--Gr\\"uss type inequality for points $x_0,x_1,x_2,\\cdots,x_k$ on time scales. Our results generalize result of Ng\\^o and Liu, and extend results of Ujevi\\'c to time scales with $(k+1$ points. We apply our results to the continuous, discrete, and quantum calculus to obtain many new interesting inequalities. An example is also considered. The estimates obtained in this paper will be very useful in numerical integration especially for the continuous case.

Statistical analysis of error rate of large-scale single flux quantum logic circuit by considering fluctuation of timing parameters

International Nuclear Information System (INIS)

Yamanashi, Yuki; Masubuchi, Kota; Yoshikawa, Nobuyuki

2016-01-01

The relationship between the timing margin and the error rate of the large-scale single flux quantum logic circuits is quantitatively investigated to establish a timing design guideline. We observed that the fluctuation in the set-up/hold time of single flux quantum logic gates caused by thermal noises is the most probable origin of the logical error of the large-scale single flux quantum circuit. The appropriate timing margin for stable operation of the large-scale logic circuit is discussed by taking the fluctuation of setup/hold time and the timing jitter in the single flux quantum circuits. As a case study, the dependence of the error rate of the 1-million-bit single flux quantum shift register on the timing margin is statistically analyzed. The result indicates that adjustment of timing margin and the bias voltage is important for stable operation of a large-scale SFQ logic circuit.

Statistical analysis of error rate of large-scale single flux quantum logic circuit by considering fluctuation of timing parameters

Energy Technology Data Exchange (ETDEWEB)

Yamanashi, Yuki, E-mail: yamanasi@ynu.ac.jp [Department of Electrical and Computer Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya-ku, Yokohama 240-8501 (Japan); Masubuchi, Kota; Yoshikawa, Nobuyuki [Department of Electrical and Computer Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya-ku, Yokohama 240-8501 (Japan)

2016-11-15

The relationship between the timing margin and the error rate of the large-scale single flux quantum logic circuits is quantitatively investigated to establish a timing design guideline. We observed that the fluctuation in the set-up/hold time of single flux quantum logic gates caused by thermal noises is the most probable origin of the logical error of the large-scale single flux quantum circuit. The appropriate timing margin for stable operation of the large-scale logic circuit is discussed by taking the fluctuation of setup/hold time and the timing jitter in the single flux quantum circuits. As a case study, the dependence of the error rate of the 1-million-bit single flux quantum shift register on the timing margin is statistically analyzed. The result indicates that adjustment of timing margin and the bias voltage is important for stable operation of a large-scale SFQ logic circuit.

Anti-control of chaos of single time-scale brushless DC motor.

Science.gov (United States)

Ge, Zheng-Ming; Chang, Ching-Ming; Chen, Yen-Sheng

2006-09-15

Anti-control of chaos of single time-scale brushless DC motors is studied in this paper. In order to analyse a variety of periodic and chaotic phenomena, we employ several numerical techniques such as phase portraits, bifurcation diagrams and Lyapunov exponents. Anti-control of chaos can be achieved by adding an external constant term or an external periodic term.

Atomistic simulations of materials: Methods for accurate potentials and realistic time scales

Science.gov (United States)

Tiwary, Pratyush

This thesis deals with achieving more realistic atomistic simulations of materials, by developing accurate and robust force-fields, and algorithms for practical time scales. I develop a formalism for generating interatomic potentials for simulating atomistic phenomena occurring at energy scales ranging from lattice vibrations to crystal defects to high-energy collisions. This is done by fitting against an extensive database of ab initio results, as well as to experimental measurements for mixed oxide nuclear fuels. The applicability of these interactions to a variety of mixed environments beyond the fitting domain is also assessed. The employed formalism makes these potentials applicable across all interatomic distances without the need for any ambiguous splining to the well-established short-range Ziegler-Biersack-Littmark universal pair potential. We expect these to be reliable potentials for carrying out damage simulations (and molecular dynamics simulations in general) in nuclear fuels of varying compositions for all relevant atomic collision energies. A hybrid stochastic and deterministic algorithm is proposed that while maintaining fully atomistic resolution, allows one to achieve milliseconds and longer time scales for several thousands of atoms. The method exploits the rare event nature of the dynamics like other such methods, but goes beyond them by (i) not having to pick a scheme for biasing the energy landscape, (ii) providing control on the accuracy of the boosted time scale, (iii) not assuming any harmonic transition state theory (HTST), and (iv) not having to identify collective coordinates or interesting degrees of freedom. The method is validated by calculating diffusion constants for vacancy-mediated diffusion in iron metal at low temperatures, and comparing against brute-force high temperature molecular dynamics. We also calculate diffusion constants for vacancy diffusion in tantalum metal, where we compare against low-temperature HTST as well

Analytical Solutions for Multi-Time Scale Fractional Stochastic Differential Equations Driven by Fractional Brownian Motion and Their Applications

Directory of Open Access Journals (Sweden)

Xiao-Li Ding

2018-01-01

Full Text Available In this paper, we investigate analytical solutions of multi-time scale fractional stochastic differential equations driven by fractional Brownian motions. We firstly decompose homogeneous multi-time scale fractional stochastic differential equations driven by fractional Brownian motions into independent differential subequations, and give their analytical solutions. Then, we use the variation of constant parameters to obtain the solutions of nonhomogeneous multi-time scale fractional stochastic differential equations driven by fractional Brownian motions. Finally, we give three examples to demonstrate the applicability of our obtained results.

Residence time distribution measurements in a pilot-scale poison tank using radiotracer technique.

Science.gov (United States)

Pant, H J; Goswami, Sunil; Samantray, J S; Sharma, V K; Maheshwari, N K

2015-09-01

Various types of systems are used to control the reactivity and shutting down of a nuclear reactor during emergency and routine shutdown operations. Injection of boron solution (borated water) into the core of a reactor is one of the commonly used methods during emergency operation. A pilot-scale poison tank was designed and fabricated to simulate injection of boron poison into the core of a reactor along with coolant water. In order to design a full-scale poison tank, it was desired to characterize flow of liquid from the tank. Residence time distribution (RTD) measurement and analysis was adopted to characterize the flow dynamics. Radiotracer technique was applied to measure RTD of aqueous phase in the tank using Bromine-82 as a radiotracer. RTD measurements were carried out with two different modes of operation of the tank and at different flow rates. In Mode-1, the radiotracer was instantaneously injected at the inlet and monitored at the outlet, whereas in Mode-2, the tank was filled with radiotracer and its concentration was measured at the outlet. From the measured RTD curves, mean residence times (MRTs), dead volume and fraction of liquid pumped in with time were determined. The treated RTD curves were modeled using suitable mathematical models. An axial dispersion model with high degree of backmixing was found suitable to describe flow when operated in Mode-1, whereas a tanks-in-series model with backmixing was found suitable to describe flow of the poison in the tank when operated in Mode-2. The results were utilized to scale-up and design a full-scale poison tank for a nuclear reactor. Copyright © 2015 Elsevier Ltd. All rights reserved.

Scaling relation between earthquake magnitude and the departure time from P wave similar growth

Science.gov (United States)

Noda, Shunta; Ellsworth, William L.

2016-01-01

We introduce a new scaling relation between earthquake magnitude (M) and a characteristic of initial P wave displacement. By examining Japanese K-NET data averaged in bins partitioned by Mw and hypocentral distance, we demonstrate that the P wave displacement briefly displays similar growth at the onset of rupture and that the departure time (Tdp), which is defined as the time of departure from similarity of the absolute displacement after applying a band-pass filter, correlates with the final M in a range of 4.5 ≤ Mw ≤ 7. The scaling relation between Mw and Tdp implies that useful information on the final M can be derived while the event is still in progress because Tdp occurs before the completion of rupture. We conclude that the scaling relation is important not only for earthquake early warning but also for the source physics of earthquakes.

Broadband Structural Dynamics: Understanding the Impulse-Response of Structures Across Multiple Length and Time Scales

Science.gov (United States)

2010-08-18

Spectral domain response calculated • Time domain response obtained through inverse transform Approach 4: WASABI Wavelet Analysis of Structural Anomalies...differences at unity scale! Time Function Transform Apply Spectral Domain Transfer Function Time Function Inverse Transform Transform Transform  mtP

Evaluation of statistical methods for quantifying fractal scaling in water-quality time series with irregular sampling

Science.gov (United States)

Zhang, Qian; Harman, Ciaran J.; Kirchner, James W.

2018-02-01

River water-quality time series often exhibit fractal scaling, which here refers to autocorrelation that decays as a power law over some range of scales. Fractal scaling presents challenges to the identification of deterministic trends because (1) fractal scaling has the potential to lead to false inference about the statistical significance of trends and (2) the abundance of irregularly spaced data in water-quality monitoring networks complicates efforts to quantify fractal scaling. Traditional methods for estimating fractal scaling - in the form of spectral slope (β) or other equivalent scaling parameters (e.g., Hurst exponent) - are generally inapplicable to irregularly sampled data. Here we consider two types of estimation approaches for irregularly sampled data and evaluate their performance using synthetic time series. These time series were generated such that (1) they exhibit a wide range of prescribed fractal scaling behaviors, ranging from white noise (β = 0) to Brown noise (β = 2) and (2) their sampling gap intervals mimic the sampling irregularity (as quantified by both the skewness and mean of gap-interval lengths) in real water-quality data. The results suggest that none of the existing methods fully account for the effects of sampling irregularity on β estimation. First, the results illustrate the danger of using interpolation for gap filling when examining autocorrelation, as the interpolation methods consistently underestimate or overestimate β under a wide range of prescribed β values and gap distributions. Second, the widely used Lomb-Scargle spectral method also consistently underestimates β. A previously published modified form, using only the lowest 5 % of the frequencies for spectral slope estimation, has very poor precision, although the overall bias is small. Third, a recent wavelet-based method, coupled with an aliasing filter, generally has the smallest bias and root-mean-squared error among all methods for a wide range of

A Review of Time-Scale Modification of Music Signals

Directory of Open Access Journals (Sweden)

Jonathan Driedger

2016-02-01

Full Text Available Time-scale modification (TSM is the task of speeding up or slowing down an audio signal’s playback speed without changing its pitch. In digital music production, TSM has become an indispensable tool, which is nowadays integrated in a wide range of music production software. Music signals are diverse—they comprise harmonic, percussive, and transient components, among others. Because of this wide range of acoustic and musical characteristics, there is no single TSM method that can cope with all kinds of audio signals equally well. Our main objective is to foster a better understanding of the capabilities and limitations of TSM procedures. To this end, we review fundamental TSM methods, discuss typical challenges, and indicate potential solutions that combine different strategies. In particular, we discuss a fusion approach that involves recent techniques for harmonic-percussive separation along with time-domain and frequency-domain TSM procedures.

Low-power operation using self-timed circuits and adaptive scaling of the supply voltage

DEFF Research Database (Denmark)

Nielsen, Lars Skovby; Niessen, C.; Sparsø, Jens

1994-01-01

Recent research has demonstrated that for certain types of applications like sampled audio systems, self-timed circuits can achieve very low power consumption, because unused circuit parts automatically turn into a stand-by mode. Additional savings may be obtained by combining the self......-timed circuits with a mechanism that adaptively adjusts the supply voltage to the smallest possible, while maintaining the performance requirements. This paper describes such a mechanism, analyzes the possible power savings, and presents a demonstrator chip that has been fabricated and tested. The idea...... of voltage scaling has been used previously in synchronous circuits, and the contributions of the present paper are: 1) the combination of supply scaling and self-timed circuitry which has some unique advantages, and 2) the thorough analysis of the power savings that are possible using this technique.>...

Time-Sliced Perturbation Theory for Large Scale Structure I: General Formalism

CERN Document Server

Blas, Diego; Ivanov, Mikhail M.; Sibiryakov, Sergey

2016-01-01

We present a new analytic approach to describe large scale structure formation in the mildly non-linear regime. The central object of the method is the time-dependent probability distribution function generating correlators of the cosmological observables at a given moment of time. Expanding the distribution function around the Gaussian weight we formulate a perturbative technique to calculate non-linear corrections to cosmological correlators, similar to the diagrammatic expansion in a three-dimensional Euclidean quantum field theory, with time playing the role of an external parameter. For the physically relevant case of cold dark matter in an Einstein--de Sitter universe, the time evolution of the distribution function can be found exactly and is encapsulated by a time-dependent coupling constant controlling the perturbative expansion. We show that all building blocks of the expansion are free from spurious infrared enhanced contributions that plague the standard cosmological perturbation theory. This pave...

ELT-scale Adaptive Optics real-time control with thes Intel Xeon Phi Many Integrated Core Architecture

Science.gov (United States)

Jenkins, David R.; Basden, Alastair; Myers, Richard M.

2018-05-01

We propose a solution to the increased computational demands of Extremely Large Telescope (ELT) scale adaptive optics (AO) real-time control with the Intel Xeon Phi Knights Landing (KNL) Many Integrated Core (MIC) Architecture. The computational demands of an AO real-time controller (RTC) scale with the fourth power of telescope diameter and so the next generation ELTs require orders of magnitude more processing power for the RTC pipeline than existing systems. The Xeon Phi contains a large number (≥64) of low power x86 CPU cores and high bandwidth memory integrated into a single socketed server CPU package. The increased parallelism and memory bandwidth are crucial to providing the performance for reconstructing wavefronts with the required precision for ELT scale AO. Here, we demonstrate that the Xeon Phi KNL is capable of performing ELT scale single conjugate AO real-time control computation at over 1.0kHz with less than 20μs RMS jitter. We have also shown that with a wavefront sensor camera attached the KNL can process the real-time control loop at up to 966Hz, the maximum frame-rate of the camera, with jitter remaining below 20μs RMS. Future studies will involve exploring the use of a cluster of Xeon Phis for the real-time control of the MCAO and MOAO regimes of AO. We find that the Xeon Phi is highly suitable for ELT AO real time control.

Multiple time scale analysis of sediment and runoff changes in the Lower Yellow River

Directory of Open Access Journals (Sweden)

K. Chi

2018-06-01

Full Text Available Sediment and runoff changes of seven hydrological stations along the Lower Yellow River (LYR (Huayuankou Station, Jiahetan Station, Gaocun Station, Sunkou Station, Ai Shan Station, Qikou Station and Lijin Station from 1980 to 2003 were alanyzed at multiple time scale. The maximum value of monthly, daily and hourly sediment load and runoff conservations were also analyzed with the annually mean value. Mann–Kendall non-parametric mathematics correlation test and Hurst coefficient method were adopted in the study. Research results indicate that (1 the runoff of seven hydrological stations was significantly reduced in the study period at different time scales. However, the trends of sediment load in these stations were not obvious. The sediment load of Huayuankou, Jiahetan and Aishan stations even slightly increased with the runoff decrease. (2 The trends of the sediment load with different time scale showed differences at Luokou and Lijin stations. Although the annually and monthly sediment load were broadly flat, the maximum hourly sediment load showed decrease trend. (3 According to the Hurst coefficients, the trend of sediment and runoff will be continue without taking measures, which proved the necessary of runoff-sediment regulation scheme.

A new approach to motion control of torque-constrained manipulators by using time-scaling of reference trajectories

Energy Technology Data Exchange (ETDEWEB)

Moreno-Valenzuela, Javier; Orozco-Manriquez, Ernesto [Digital del IPN, CITEDI-IPN, Tijuana, (Mexico)

2009-12-15

We introduce a control scheme based on using a trajectory tracking controller and an algorithm for on-line time scaling of the reference trajectories. The reference trajectories are time-scaled according to the measured tracking errors and the detected torque/acceleration saturation. Experiments are presented to illustrate the advantages of the proposed approach

A new approach to motion control of torque-constrained manipulators by using time-scaling of reference trajectories

International Nuclear Information System (INIS)

Moreno-Valenzuela, Javier; Orozco-Manriquez, Ernesto

2009-01-01

We introduce a control scheme based on using a trajectory tracking controller and an algorithm for on-line time scaling of the reference trajectories. The reference trajectories are time-scaled according to the measured tracking errors and the detected torque/acceleration saturation. Experiments are presented to illustrate the advantages of the proposed approach

Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 113: Reactor Maintenance, Assembly, and Disassembly Building Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

J. L. Smith

2001-01-01

This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the action necessary for the closure in place of Corrective Action Unit (CAU) 113 Area 25 Reactor Maintenance, Assembly, and Disassembly Facility (R-MAD). CAU 113 is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO) (NDEP, 1996). The CAU is located in Area 25 of the Nevada Test Site (NTS) and consists of Corrective Action Site (CAS) 25-04-01, R-MAD Facility (Figures 1-2). This plan provides the methodology for closure in place of CAU 113. The site contains radiologically impacted and hazardous material. Based on preassessment field work, there is sufficient process knowledge to close in place CAU 113 using the SAFER process. At a future date when funding becomes available, the R-MAD Building (25-3110) will be demolished and inaccessible radiologic waste will be properly disposed in the Area 3 Radiological Waste Management Site (RWMS).

Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 113: Reactor Maintenance, Assembly, and Disassembly Building Nevada Test Site, Nevada

International Nuclear Information System (INIS)

Smith, J. L.

2001-01-01

This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the action necessary for the closure in place of Corrective Action Unit (CAU) 113 Area 25 Reactor Maintenance, Assembly, and Disassembly Facility (R-MAD). CAU 113 is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO) (NDEP, 1996). The CAU is located in Area 25 of the Nevada Test Site (NTS) and consists of Corrective Action Site (CAS) 25-04-01, R-MAD Facility (Figures 1-2). This plan provides the methodology for closure in place of CAU 113. The site contains radiologically impacted and hazardous material. Based on preassessment field work, there is sufficient process knowledge to close in place CAU 113 using the SAFER process. At a future date when funding becomes available, the R-MAD Building (25-3110) will be demolished and inaccessible radiologic waste will be properly disposed in the Area 3 Radiological Waste Management Site (RWMS)

Wood cell-wall structure requires local 2D-microtubule disassembly by a novel plasma membrane-anchored protein.

Science.gov (United States)

Oda, Yoshihisa; Iida, Yuki; Kondo, Yuki; Fukuda, Hiroo

2010-07-13

Plant cells have evolved cortical microtubules, in a two-dimensional space beneath the plasma membrane, that regulate patterning of cellulose deposition. Although recent studies have revealed that several microtubule-associated proteins facilitate self-organization of transverse cortical microtubules, it is still unknown how diverse patterns of cortical microtubules are organized in different xylem cells, which are the major components of wood. Using our newly established in vitro xylem cell differentiation system, we found that a novel microtubule end-tracking protein, microtubule depletion domain 1 (MIDD1), was anchored to distinct plasma membrane domains and promoted local microtubule disassembly, resulting in pits on xylem cell walls. The introduction of RNA interference for MIDD1 resulted in the failure of local microtubule depletion and the formation of secondary walls without pits. Conversely, the overexpression of MIDD1 reduced microtubule density. MIDD1 has two coiled-coil domains for the binding to microtubules and for the anchorage to plasma membrane domains, respectively. Combination of the two coils caused end tracking of microtubules during shrinkage and suppressed their rescue events. Our results indicate that MIDD1 integrates spatial information in the plasma membrane with cortical microtubule dynamics for determining xylem cell wall pattern. Copyright 2010 Elsevier Ltd. All rights reserved.

Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling.

Science.gov (United States)

Pakhomov, Andrei G; Xiao, Shu; Pakhomova, Olga N; Semenov, Iurii; Kuipers, Marjorie A; Ibey, Bennett L

2014-12-01

Disruption of the actin cytoskeleton structures was reported as one of the characteristic effects of nanosecond-duration pulsed electric field (nsPEF) in both mammalian and plant cells. We utilized CHO cells that expressed the monomeric fluorescent protein (mApple) tagged to actin to test if nsPEF modifies the cell actin directly or as a consequence of cell membrane permeabilization. A train of four 600-ns pulses at 19.2 kV/cm (2 Hz) caused immediate cell membrane poration manifested by YO-PRO-1 dye uptake, gradual cell rounding and swelling. Concurrently, bright actin features were replaced by dimmer and uniform fluorescence of diffuse actin. To block the nsPEF-induced swelling, the bath buffer was isoosmotically supplemented with an electropore-impermeable solute (sucrose). A similar addition of a smaller, electropore-permeable solute (adonitol) served as a control. We demonstrated that sucrose efficiently blocked disassembly of actin features by nsPEF, whereas adonitol did not. Sucrose also attenuated bleaching of mApple-tagged actin in nsPEF-treated cells (as integrated over the cell volume), although did not fully prevent it. We conclude that disintegration of the actin cytoskeleton was a result of cell swelling, which, in turn, was caused by cell permeabilization by nsPEF and transmembrane diffusion of solutes which led to the osmotic imbalance. Copyright © 2014 Elsevier B.V. All rights reserved.

Superconducting fluctuations and characteristic time scales in amorphous WSi

Science.gov (United States)

Zhang, Xiaofu; Lita, Adriana E.; Sidorova, Mariia; Verma, Varun B.; Wang, Qiang; Nam, Sae Woo; Semenov, Alexei; Schilling, Andreas

2018-05-01

We study magnitudes and temperature dependencies of the electron-electron and electron-phonon interaction times which play the dominant role in the formation and relaxation of photon-induced hotspots in two-dimensional amorphous WSi films. The time constants are obtained through magnetoconductance measurements in a perpendicular magnetic field in the superconducting fluctuation regime and through time-resolved photoresponse to optical pulses. The excess magnetoconductivity is interpreted in terms of the weak-localization effect and superconducting fluctuations. Aslamazov-Larkin and Maki-Thompson superconducting fluctuations alone fail to reproduce the magnetic field dependence in the relatively high magnetic field range when the temperature is rather close to Tc because the suppression of the electronic density of states due to the formation of short-lifetime Cooper pairs needs to be considered. The time scale τi of inelastic scattering is ascribed to a combination of electron-electron (τe -e) and electron-phonon (τe -p h) interaction times, and a characteristic electron-fluctuation time (τe -f l) , which makes it possible to extract their magnitudes and temperature dependencies from the measured τi. The ratio of phonon-electron (τp h -e) and electron-phonon interaction times is obtained via measurements of the optical photoresponse of WSi microbridges. Relatively large τe -p h/τp h -e and τe -p h/τe -e ratios ensure that in WSi the photon energy is more efficiently confined in the electron subsystem than in other materials commonly used in the technology of superconducting nanowire single-photon detectors (SNSPDs). We discuss the impact of interaction times on the hotspot dynamics and compare relevant metrics of SNSPDs from different materials.