Synthesis of Taxol-Like Prostate Cancer Chemotherapeutic Agents

National Research Council Canada - National Science Library

Jo, Hyunil

2008-01-01

This report describes the synthetic approaches toward a potent microtubule stabilizing natural product, eleutherobin, utilizing tandem Diels-Alder reaction/Grob-type fragmentation reaction as key steps...

Planning of a small hydroelectric installation project - orientation aids; Vom Plan zum Werk - Orientierungshilfen

Energy Technology Data Exchange (ETDEWEB)

Hutarew, A. [Dr. Hutarew und Partner, Pforzheim (Germany)

1997-12-31

The article informs in concise form on essential elements of the plannning of a small hydro power project. Understanding and considerateness are demanded from all parties concerned when such a joint project is envisaged. Not one-sided interests should be followed; rather, everyone should contribute towards facilitating renewable energy generation. Some negative examples are cited. (orig.) [Deutsch] In der Kuerze der gebotenen Zeit wurde versucht, wesentliche Eckpfeiler in der Entstehung einer Wasserkraftanlage zu skizzieren. Ziel meiner Ausfuehrungen ist es, von allen Beteiligten Verstaendnis abzuverlangen und Ruecksichtnahme zu praktizieren, geht es doch darum, ein gemeinsames Werk entstehen zu lassen. Wir stehen nicht in der Not, einseitige Interessen zu verfechten, sondern gemeinsam an einem Baustein regenerativer Energieerzeugung zu arbeiten. Es sei mir verziehen, wenn durch die Schilderung von Negativ-Beispielen ein eher unueblicher Weg beschritten wurde. (orig.)

Memoization in Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Balat, Vincent; Danvy, Olivier

2002-01-01

We use a code generator—type-directed partial evaluation— to verify conversions between isomorphic types, or more precisely to verify that a composite function is the identity function at some complicated type. A typed functional language such as ML provides a natural support to express the funct......We use a code generator—type-directed partial evaluation— to verify conversions between isomorphic types, or more precisely to verify that a composite function is the identity function at some complicated type. A typed functional language such as ML provides a natural support to express...... originate in the handling of sums, which uses delimited continuations. We successfully eliminate these redundancies by extending type-directed partial evaluation with memoization capabilities. The result only works for pure functional programs, but it provides an unexpected use of code generation...... and it yields orders-of-magnitude improvements both in time and in space for type isomorphisms. Basic Research in Computer Science (www. brics. dk), funded by the Danish National Research Foundation....

Memoization in Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Balat, Vincent; Danvy, Olivier

2002-01-01

the functions and type-directed partial evaluation provides a convenient setting to obtain the normal form of their composition. However, off-the-shelf type-directed partial evaluation turns out to yield gigantic normal forms. We identify that this gigantism is due to redundancies, and that these redundancies...

Memorization in Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Balat, Vincent; Danvy, Olivier

2002-01-01

We use a code generator—type-directed partial evaluation— to verify conversions between isomorphic types, or more precisely to verify that a composite function is the identity function at some complicated type. A typed functional language such as ML provides a natural support to express the funct...

Pragmatics of type-directed partial evaluation

DEFF Research Database (Denmark)

Danvy, Olivier

1996-01-01

Type-directed partial evaluation stems from the residualization of static values in dynamic contexts, given their type and the type of their free variables. Its algorithm coincides with the algorithm for coercing a subtype value into a supertype value, which itself coincides with Berger and Schwi...

Multi-Type Directed Scale-Free Percolation

International Nuclear Information System (INIS)

Shang Yilun

2012-01-01

In this paper, we study a long-range percolation model on the lattice ℤ d with multi-type vertices and directed edges. Each vertex x in ℤ d is independently assigned a non-negative weight W x and a type ψ x , where (W x ) xinℤ d are i.i.d. random variables, and (ψ x ) xinℤ d are also i.i.d. Conditionally on weights and types, and given λ, α > 0, the edges are independent and the probability that there is a directed edge from x to y is given by p xy = 1 - exp(-λφ ψ x ψ y W x W y /|x-y| α ), where φ ij 's are entries from a type matrix Φ. We show that, when the tail of the distribution of W x is regularly varying with exponent τ - 1, the tails of the out/in-degree distributions are both regularly varying with exponent γ = α(τ - 1)/d. We formulate conditions under which there exist critical values λ c WCC in (0, ∞) and λ c SCC in (0, ∞) such that an infinite weak component and an infinite strong component emerge, respectively, when λ exceeds them. A phase transition is established for the shortest path lengths of directed and undirected edges in the infinite component at the point γ = 2, where the out/in-degrees switch from having finite to infinite variances. The random graph model studied here features some structures of multi-type vertices and directed edges which appear naturally in many real-world networks, such as the SNS networks and computer communication networks. (condensed matter: structural, mechanical, and thermal properties)

Comparison of imaging properties of direct-type and indirect-type of flat-panel detector

International Nuclear Information System (INIS)

Matsumoto, Masao; Suekane, Koji; Ichimaru, Yasunobu; Ogata, Yuji; Inamura, Kiyonari; Kanai, Kouzou; Kanamori, Hitoshi

2002-01-01

A Flat-Panel Detector (FPD) has many advantages such as eliminating cassette handling and being able to display a preview image immediately in addition to the digital image processing and the networking. Thus, the FPD has ability to innovate the radiology department. We measured and evaluated the digital and over-all imaging properties (characteristic curves, modulation Transfer Functions, Wiener spectra and Noise Equivalent Quanta (NEQ) for the direct-type and indirect-type of FPD. The pre-sampling and overall NEQ of the indirect-type of FPD were better than the NEQ of the direct-type of FPD at lower spatial frequencies, but were worse at higher spatial frequencies. The FPD can take image data at real-time and be easy to digitalize. From these results, Screen/Film system and Computed Radiography system will be replaced by the FPD system, together with diffusion of CAD, cone beam Computed Tomography (CT) system and open-type Magnetic Resonance Imagining (MRI) system. (T. Tanaka)

Βιβλιοκρισία:P. SCHREINER-E. VOGT(eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011

Directory of Open Access Journals (Sweden)

Walter PUCHNER

2013-04-01

Full Text Available Βιβλιοκρισία: P. Schreiner-E. Vogt (eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011 (Bayerische Akademie der Wissenschaften, Philosophisch-historische Klasse, Sitzungsberichte, Jahrgang 2011, Heft 4, σελ. 147, 5 εικ., ΙSBN 978 3 7696 1569 0.

UBER DEN BEITRITT DER PLURIMODALITÄT DES VERSTEHENS DER NICHTEUROPÄISCHEN TRADITION. DISCOURS ÜBER DISCOURS. (PROBLEMATISIERUNG INITIERT MIT DEM WERK "CARSTVO ZNAKOVA" VON ROLAND BARTHES, AUGUST CESAREC, ZAGREB 1989

Directory of Open Access Journals (Sweden)

Jadran Zalokar

1990-01-01

Full Text Available In diesem Text problematisiert der Verfasser manche grundsätzlicke Fragen des Verstehens nichteuropäischen Traditionen im Ganzen. Dabei analysiert er das Werk von Roland Barthes in Zusammenhang des Verstehens der Beziehung textuallen im Gegensatz zum geistlichen Tradition Japans, gleichzeitig auf die methodologisch wichtige Frage hinweisend. Alles enken und "Schreiben" darüber ist in nuce zweifelhaft. Das Denken des planetaren Polilogen als Multiloge verlangt einen strengen wissenschaftlichen Beitritt, aber auch einen metawissenschaftlichen und metaphilosphischen Einblick in das geistliche Wesen nichteuropäischen Tradition, weil es gleichmäßige Beachtung verschiedensten geistlichen Erfahrungen und Eingenartigkeiten des geistlichen Lebens aller Traditionen nötig ist und nurwissenschaftlicher und nurphilosophischer Beitritt ist nicht genügend.

Direct cycle type nuclear power plant

International Nuclear Information System (INIS)

Tagawa, Hisato; Ibe, Hidefumi.

1990-01-01

In a direct cycle type nuclear power plant such as BWR type reactor, since oxygen atoms in reactor water are actuvated by neutron irradiation in the reactor core, carry over of the thus formed radioactive nitrogen atoms causes increase in the dosage in a turbine system. Since 16 N accompanies in the main steams in the chemical form of 16 NO, it can not effectively be removed in a nitrogen removing device. In view of the above, hydrogen atom concentration is reduced by adding metals having high reaction with hydrogen atoms, for example, silver ions, chromium ions, or ruthenium ions are added to reactor water. Then, equilibrium concentration of 16 NO in water is reduced by suppressing the reaction: 16 NO 2 + H → 16 NO + OH. (T.M.)

A systematic review of the direct economic burden of type 2 diabetes in china.

Science.gov (United States)

Hu, Huimei; Sawhney, Monika; Shi, Lizheng; Duan, Shengnan; Yu, Yunxian; Wu, Zhihong; Qiu, Guixing; Dong, Hengjin

2015-03-01

Type 2 diabetes is associated with acute and chronic complications and poses a large economic, social, and medical burden on patients and their families as well as society. This study aims to evaluate the direct economic burden of type 2 diabetes in China. systematic review on cost of illness, health care costs, direct service costs, drug costs, and health expenditures in relation to type 2 diabetes was conducted up to 2014 using databases such as Pubmed; EBSCO; Elsevier ScienceDirect, Web of Science; and a series of Chinese databases, including Wanfang Data, China National Knowledge Infrastructure (CNKI), and the China Science and Technology Journal Database. Factors influencing hospitalization and drug fees were also identified. (1) estimation of the direct economic burden including hospitalization and outpatient cost of type 2 diabetes patients in China; (2) evaluation of the factors influencing the direct economic burden. Articles only focusing on the cost-effectiveness analysis of diabetes drugs were excluded. The direct economic burden of type 2 diabetes has increased over time in China, and in 2008, the direct medical cost reached $9.1 billion, Both outpatient and inpatient costs have increased. Income level, type of medical insurance, the level of hospital care, and type and number of complications are primary factors influencing diabetes related hospitalization costs. Compared to urban areas, the direct non-medical cost of type 2 diabetes in rural areas is significantly greater. The direct economic burden of type 2 diabetes poses a significant challenge to China. To address the economic burden associated with type 2 diabetes, measures need to be taken to reduce prevalence rate and severity of diabetes and hospitalization cost.

Drie redenen waarom mensen zich zonder betaling ten volle inzetten: opiniërend

NARCIS (Netherlands)

Ridder Schueren van der, M. de; Zwetsloot, G.

2016-01-01

Terwijl betaald werk steeds meer wordt gerationaliseerd en door managers, aangestuurd met veelal primair een financiële doelstelling, ligt dat heel anders bij vrijwillig werk. Bij het verrichten van betaald werk is het genereren van inkomen voor velen essentieel. Vrijwillig werk wordt niet betaald,

Variable type framing in Spanish constructions of directed motion

DEFF Research Database (Denmark)

Pedersen, Johan

2014-01-01

demonstrate in this article that this construction type tends to be acceptable whenever the lexical meaning of the verb implies an element of directed motion. Drawing on Goldberg (2006) and Pedersen (2009, 2013), I suggest that schematicity is a typological parameter, and, more specifically, that the term...... variable type framing may accommodate the case of variation under scrutiny here....

Development of a Single Locus Sequence Typing (SLST) Scheme for Typing Bacterial Species Directly from Complex Communities.

Science.gov (United States)

Scholz, Christian F P; Jensen, Anders

2017-01-01

The protocol describes a computational method to develop a Single Locus Sequence Typing (SLST) scheme for typing bacterial species. The resulting scheme can be used to type bacterial isolates as well as bacterial species directly from complex communities using next-generation sequencing technologies.

Type Directed Partial Evaluation for Level-1 Shift and Reset

Directory of Open Access Journals (Sweden)

Danko Ilik

2013-09-01

Full Text Available We present an implementation in the Coq proof assistant of type directed partial evaluation (TDPE algorithms for call-by-name and call-by-value versions of shift and reset delimited control operators, and in presence of strong sum types. We prove that the algorithm transforms well-typed programs to ones in normal form. These normal forms can not always be arrived at using the so far known equational theories. The typing system does not allow answer-type modification for function types and allows delimiters to be set on at most one atomic type. The semantic domain for evaluation is expressed in Constructive Type Theory as a dependently typed monadic structure combining Kripke models and continuation passing style translations.

78 FR 76050 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

Science.gov (United States)

2013-12-16

... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeron[aacute]uticas, S.A... rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain EADS CASA (Type...., Washington, DC. For EADS-CASA service information identified in this AD, contact EADS-CASA, Military...

Direct stimulation of angiotensin II type 2 receptor enhances spatial memory

DEFF Research Database (Denmark)

Jing, Fei; Mogi, Masaki; Sakata, Akiko

2012-01-01

We examined the possibility that direct stimulation of the angiotensin II type 2 (AT(2)) receptor by a newly generated direct AT(2) receptor agonist, Compound 21 (C21), enhances cognitive function. Treatment with C21 intraperitoneal injection for 2 weeks significantly enhanced cognitive function...

Linear–Quadratic Mean-Field-Type Games: A Direct Method

Directory of Open Access Journals (Sweden)

Tyrone E. Duncan

2018-02-01

Full Text Available In this work, a multi-person mean-field-type game is formulated and solved that is described by a linear jump-diffusion system of mean-field type and a quadratic cost functional involving the second moments, the square of the expected value of the state, and the control actions of all decision-makers. We propose a direct method to solve the game, team, and bargaining problems. This solution approach does not require solving the Bellman–Kolmogorov equations or backward–forward stochastic differential equations of Pontryagin’s type. The proposed method can be easily implemented by beginners and engineers who are new to the emerging field of mean-field-type game theory. The optimal strategies for decision-makers are shown to be in a state-and-mean-field feedback form. The optimal strategies are given explicitly as a sum of the well-known linear state-feedback strategy for the associated deterministic linear–quadratic game problem and a mean-field feedback term. The equilibrium cost of the decision-makers are explicitly derived using a simple direct method. Moreover, the equilibrium cost is a weighted sum of the initial variance and an integral of a weighted variance of the diffusion and the jump process. Finally, the method is used to compute global optimum strategies as well as saddle point strategies and Nash bargaining solution in state-and-mean-field feedback form.

Tree-type values for cycle-free directed graph games

NARCIS (Netherlands)

Khmelnitskaya, Anna Borisovna; Talman, Dolf

2010-01-01

For arbitrary cycle-free directed graph games tree-type values are introduced axiomatically and their explicit formula representation is provided. These values may be considered as natural extensions of the tree and sink values as has been defined correspondingly for rooted and sink forest graph

Evaluation of a new type of direct digital radiography machine ...

African Journals Online (AJOL)

Evaluation of a new type of direct digital radiography machine. ... Ease of use, anatomical coverage and tolerance to patient motion were advantages. ... to that of conventional radiographs, with limited fine detail visibility and penetration.

Dynamics of introduction of type teaching of senior pupils to sporting direction in Ukraine

Directory of Open Access Journals (Sweden)

Voitovych I.N.

2012-07-01

Full Text Available The indexes of dynamics of introduction of sporting direction of the type teaching of senior pupils in Ukraine are resulted. In research is utillized statistical information of different organizations in relation to activity of the type teaching. The percent distributing of students of sporting classes and establishments in which they study on regions is set. The levels of scope of senior pupils this type of studies are selected depending on the region of residence. The tendency of the personal interest of schoolboys a physical culture and sport at type level is marked. Sporting direction of the type teaching is selected, that allows organize professional preparation of students of senior school in industry of physical culture, sport and tourism. It is set that on the whole on Ukraine the middle index of percent of students which wished to visit the type classes of sporting direction hesitated from 2,6% to 3,0%.

An Extended Multilocus Sequence Typing (MLST) Scheme for Rapid Direct Typing of Leptospira from Clinical Samples

OpenAIRE

Weiss, Sabrina; Menezes, Angela; Woods, Kate; Chanthongthip, Anisone; Dittrich, Sabine; Opoku-Boateng, Agatha; Kimuli, Maimuna; Chalker, Victoria

2016-01-01

Background Rapid typing of Leptospira is currently impaired by requiring time consuming culture of leptospires. The objective of this study was to develop an assay that provides multilocus sequence typing (MLST) data direct from patient specimens while minimising costs for subsequent sequencing. Methodology and Findings An existing PCR based MLST scheme was modified by designing nested primers including anchors for facilitated subsequent sequencing. The assay was applied to various specimen t...

[The significance of low-frequency magnetotherapy for local treatment of burns. An experimental comparative approach (author's transl)].

Science.gov (United States)

Sauer, H D; Rudy, D

1980-02-01

Under standardized experimental conditions 3rd degree burns were produced on the neck of 241 Wistar-rats. The process of wound-healing was documented by means of planimetric, histologic and microbiologic methods. In comparison to an untreated control-group the effectiveness of low-frequency magnetotherapy (system magnetodyn 5 by W. Krauss) as well as coagulation of necrosis according to Grob and autologous skin-transplantation were studied. The results obtained indicate that only early debridement of necrosis and subsequent autologous skin-grafting guarantees sufficient acceleration of wound healing. The low-frequency magnetotherapy according to Krauss showed no effect of therapeutic value. With the coagulation of necrosis, as described by Grob, a germfree status under the necrosis was obtained for nearly 2 weeks.

Pupils' Humour Directed at Teachers: Its Types and Functions

Science.gov (United States)

Šedová, Klára

2013-01-01

Based on an analysis of 137 texts written by pupils, this paper examines pupils' humour directed at teachers, its types and social functions. The collected data are divided into three categories that describe different modes of teachers as targets of pupils' humour. The first mode describes teachers as unintentionally comical, the second as duped…

De digitale stresscoach : totale controle over je mentale gezondheid of Big Brother is watching you?

NARCIS (Netherlands)

Lieshout, M. van; Wiezer, N.; Korte, E. de

2014-01-01

Een digitale coach die je helpt stress op je werk te verminderen en meer energie uit je werk te halen klinkt aantrekkelijk. Stress ervaren we immers allemaal. Net zoals we allemaal streven naar werk waar je energie van krijgt. En stress vermijden we liever. Stress is een maatschappelijk probleem en

Strong normalization by type-directed partial evaluation and run-time code generation

DEFF Research Database (Denmark)

Balat, Vincent; Danvy, Olivier

1998-01-01

We investigate the synergy between type-directed partial evaluation and run-time code generation for the Caml dialect of ML. Type-directed partial evaluation maps simply typed, closed Caml values to a representation of their long βη-normal form. Caml uses a virtual machine and has the capability...... to load byte code at run time. Representing the long βη-normal forms as byte code gives us the ability to strongly normalize higher-order values (i.e., weak head normal forms in ML), to compile the resulting strong normal forms into byte code, and to load this byte code all in one go, at run time. We...... conclude this note with a preview of our current work on scaling up strong normalization by run-time code generation to the Caml module language....

Strong Normalization by Type-Directed Partial Evaluation and Run-Time Code Generation

DEFF Research Database (Denmark)

Balat, Vincent; Danvy, Olivier

1997-01-01

We investigate the synergy between type-directed partial evaluation and run-time code generation for the Caml dialect of ML. Type-directed partial evaluation maps simply typed, closed Caml values to a representation of their long βη-normal form. Caml uses a virtual machine and has the capability...... to load byte code at run time. Representing the long βη-normal forms as byte code gives us the ability to strongly normalize higher-order values (i.e., weak head normal forms in ML), to compile the resulting strong normal forms into byte code, and to load this byte code all in one go, at run time. We...... conclude this note with a preview of our current work on scaling up strong normalization by run-time code generation to the Caml module language....

An Extended Multilocus Sequence Typing (MLST Scheme for Rapid Direct Typing of Leptospira from Clinical Samples.

Directory of Open Access Journals (Sweden)

Sabrina Weiss

2016-09-01

Full Text Available Rapid typing of Leptospira is currently impaired by requiring time consuming culture of leptospires. The objective of this study was to develop an assay that provides multilocus sequence typing (MLST data direct from patient specimens while minimising costs for subsequent sequencing.An existing PCR based MLST scheme was modified by designing nested primers including anchors for facilitated subsequent sequencing. The assay was applied to various specimen types from patients diagnosed with leptospirosis between 2014 and 2015 in the United Kingdom (UK and the Lao Peoples Democratic Republic (Lao PDR. Of 44 clinical samples (23 serum, 6 whole blood, 3 buffy coat, 12 urine PCR positive for pathogenic Leptospira spp. at least one allele was amplified in 22 samples (50% and used for phylogenetic inference. Full allelic profiles were obtained from ten specimens, representing all sample types (23%. No nonspecific amplicons were observed in any of the samples. Of twelve PCR positive urine specimens three gave full allelic profiles (25% and two a partial profile. Phylogenetic analysis allowed for species assignment. The predominant species detected was L. interrogans (10/14 and 7/8 from UK and Lao PDR, respectively. All other species were detected in samples from only one country (Lao PDR: L. borgpetersenii [1/8]; UK: L. kirschneri [1/14], L. santarosai [1/14], L. weilii [2/14].Typing information of pathogenic Leptospira spp. was obtained directly from a variety of clinical samples using a modified MLST assay. This assay negates the need for time-consuming culture of Leptospira prior to typing and will be of use both in surveillance, as single alleles enable species determination, and outbreaks for the rapid identification of clusters.

Mathematical model of snake-type multi-directional wave generation

Science.gov (United States)

Muarif; Halfiani, Vera; Rusdiana, Siti; Munzir, Said; Ramli, Marwan

2018-01-01

Research on extreme wave generation is one intensive research on water wave study because the fact that the occurrence of this wave in the ocean can cause serious damage to the ships and offshore structures. One method to be used to generate the wave is self-correcting. This method controls the signal on the wavemakers in a wave tank. Some studies also consider the nonlinear wave generation in a wave tank by using numerical approach. Study on wave generation is essential in the effectiveness and efficiency of offshore structure model testing before it can be operated in the ocean. Generally, there are two types of wavemakers implemented in the hydrodynamic laboratory, piston-type and flap-type. The flap-type is preferred to conduct a testing to a ship in deep water. Single flap wavemaker has been explained in many studies yet snake-type wavemaker (has more than one flap) is still a case needed to be examined. Hence, the formulation in controlling the wavemaker need to be precisely analyzed such that the given input can generate the desired wave in the space-limited wave tank. By applying the same analogy and methodhology as the previous study, this article represents multi-directional wave generation by implementing snake-type wavemakers.

78 FR 11567 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2013-02-19

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39...

76 FR 70040 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

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2011-11-10

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (type certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and... new AD: 2011-23-07 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft...

76 FR 6525 - Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia...

Science.gov (United States)

2011-02-07

... Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia Aircraft... following new AD: 2011-03-04 Cessna Aircraft Company (Type Certificate Previously Held by Columbia Aircraft... the following Cessna Aircraft Company (type certificate previously held by Columbia Aircraft...

The Second Futamura Projection for Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Grobauer, Bernd; Yang, Zhe

2001-01-01

', syntax-directed partial evaluation and TDPE, this derivation involves several conceptual and technical steps. These include a suitable formulation of the second Futamura projection and techniques for using TDPE to specialize type-indexed programs. In the context of the second Futamura projection, we also...... compare and relate TDPE with conventional offline partial evaluation. We demonstrate our technique with several examples, including compiler generation for Tiny, a prototypical imperative language....

Tanne plant - first results of soil treatment according to the anaerobic/aerobic method; Werk Tanne - Erste Ergebnisse der Bodenbehandlung nach dem Anaerob-Aerob-Verfahren

Energy Technology Data Exchange (ETDEWEB)

Fischer, D.; Walter, U. [Umweltschutz Nord GmbH, Ganderkesee (Germany)

1999-02-01

Biological remediation of STV contaminated sites has been a major focus of the promotion activities of the Federal Research and Education Ministry (BMFB) for some years now. For this purpose the BMFB has drawn together diverse integrated research projects to bring a well-coordinated force of activities to bear on this problem in a manner unprecedented in Germany. Its declared aim in doing so is, firstly, to compile a guide on biological remediation and, secondly, to funnel the output of all ongoing German research in this field into the second phase of its research activities at the ''Tanne'' plant in Clausthal-Zellerfeld, which is dedicated to practice-oriented testing of methods for the biological remediation of STV contaminated sites. [German] Die biologische Sanierung von Standorten, welche mit STV kontaminiert sind, ist seit einigen Jahren eines der markanten Ziele der BMBF-Forschungsfoerderungen. Durch die bislang in der bundesweiten Forschung einmalige, Forschungsverbund uebergreifende, koordinierte Buendelung saemtlicher wissenschaftlicher Aktivitaeten ist es erklaertes Ziel, zum einen einen Leitfaden zur biologischen Sanierung herauszuarbeiten, zum anderen, die aktuellen, bundesweiten, wissenschaftlichen Erkenntnisse in die seit Mai 1998 am Standort 'Werk Tanne' in Clausthal-Zellerfeld laufende Phase 2 der BMBF-Forschungsaktivitaeten, naemlich die praxisorientierte Erprobung von Verfahren zur biologischen Sanierung von STV-belasteten Standorten, einzugreifen. (orig.)

77 FR 14316 - Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper...

Science.gov (United States)

2012-03-09

...-0251; Directorate Identifier 2012-CE-002-AD] RIN 2120-AA64 Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper Aircraft Inc.) Airplanes AGENCY: Federal... supersede an existing airworthiness directive (AD) that applies to certain Piper Aircraft, Inc. (type...

Chichibabin-type direct alkylation of pyridyl alcohols with alkyl lithium reagents.

Science.gov (United States)

Jeffrey, Jenna L; Sarpong, Richmond

2012-11-02

Direct C(6) alkylation of pyridyl alcohols can be achieved following an initial deprotonation of the hydroxy group. This transformation, which is believed to occur by a Chichibabin-type alkylation, avoids lateral deprotonation prior to pyridine ring alkylation and gives increased regioselectivity for C(6) over C(4) alkylation.

75 FR 57844 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2010-09-23

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39-16438. Docket No. FAA-2010-0555... (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200...

77 FR 64767 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-10-23

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... airworthiness directive (AD) for certain Gulfstream Aerospace LP (Type Certificate previously held by Israel... Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes...

78 FR 47546 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

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2013-08-06

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model... Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli...

76 FR 53633 - Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by...

Science.gov (United States)

2011-08-29

... Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by Bombardier Inc. and de... superseding an existing airworthiness directive (AD) for all Viking Air Limited (type certificate No. A-815..., contact Viking Air Ltd., 9574 Hampden Road, Sidney, BC Canada V8L 5V5; telephone: (800) 663-8444; Internet...

76 FR 1349 - Airworthiness Directives; Cessna Aircraft Company (Cessna) (Type Certificate A00003SE Previously...

Science.gov (United States)

2011-01-10

... Airworthiness Directives; Cessna Aircraft Company (Cessna) (Type Certificate A00003SE Previously Held by... Company (Type Certificate A00003SE previously held by Columbia Aircraft Manufacturing (previously The... Cessna Aircraft Company (Cessna) (Type Certificate A00003SE previously held by Columbia Aircraft...

75 FR 28485 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2010-05-21

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39... previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100 airplanes; and Model Astra SPX and...

75 FR 36296 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

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2010-06-25

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... contact we receive about this proposed AD. Discussion The Civil Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli Airworthiness Directive 01-10-01-07R1, dated...

77 FR 44113 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-07-27

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... to the manufacturer. This action was prompted by a report from the Civil Aviation Authority of Israel...

On the Directivity of Low-Frequency Type IV Radio Bursts

Science.gov (United States)

Gopalswamy, N.; Akiyama, S.; Makela, P.; Yashiro, S.; Cairns, I. H.

2016-01-01

An intense type IV radio burst was observed by the STEREO Behind (STB) spacecraft located about 144 deg. behind Earth. The burst was associated with a large solar eruption that occurred on the backside of the Sun (N05E151) close to the disk center in the STB view. The eruption was also observed by the STEREO Ahead (STA) spacecraft (located at 149 deg. ahead of Earth) as an eruption close to the west limb (N05W60) in that view. The type IV burst was complete in STB observations in that the envelope reached the lowest frequency and then receded to higher frequencies. The burst was partial viewed from STA, revealing only the edge coming down to the lowest frequency. The type IV burst was not observed at all near Earth because the source was 61 deg. behind the east limb. The eruption was associated with a low-frequency type II burst observed in all three views, although it was not very intense. Solar energetic particles were also observed at both STEREOs and at SOHO, suggesting that the shock was much extended, consistent with the very high speed of the CME (2048 km/s). These observations suggest that the type IV emission is directed along a narrow cone above the flare site. We confirm this result statistically using the type IV bursts of solar cycle 23.

Direct typing of Canine parvovirus (CPV) from infected dog faeces by rapid mini sequencing technique.

Science.gov (United States)

V, Pavana Jyothi; S, Akila; Selvan, Malini K; Naidu, Hariprasad; Raghunathan, Shwethaa; Kota, Sathish; Sundaram, R C Raja; Rana, Samir Kumar; Raj, G Dhinakar; Srinivasan, V A; Mohana Subramanian, B

2016-12-01

Canine parvovirus (CPV) is a non-enveloped single stranded DNA virus with an icosahedral capsid. Mini-sequencing based CPV typing was developed earlier to detect and differentiate all the CPV types and FPV in a single reaction. This technique was further evaluated in the present study by performing the mini-sequencing directly from fecal samples which avoided tedious virus isolation steps by cell culture system. Fecal swab samples were collected from 84 dogs with enteritis symptoms, suggestive of parvoviral infection from different locations across India. Seventy six of these samples were positive by PCR; the subsequent mini-sequencing reaction typed 74 of them as type 2a virus, and 2 samples as type 2b. Additionally, 25 of the positive samples were typed by cycle sequencing of PCR products. Direct CPV typing from fecal samples using mini-sequencing showed 100% correlation with CPV typing by cycle sequencing. Moreover, CPV typing was achieved by mini-sequencing even with faintly positive PCR amplicons which was not possible by cycle sequencing. Therefore, the mini-sequencing technique is recommended for regular epidemiological follow up of CPV types, since the technique is rapid, highly sensitive and high capacity method for CPV typing. Copyright © 2016. Published by Elsevier B.V.

Directing factors affecting the synthesis of a MFI-type zeolite

Energy Technology Data Exchange (ETDEWEB)

Vinaches, P.; Pergher, S.B.C. [Universidade Federal de Rio Grande do Norte (UFRN), RN (Brazil); Lopes, C.W. [Institute of Chemical Technology, Mumbai (India); Gomez-Hortiguela, L. [Instituto de Catalisis y Petroleoquimica, Madrid (Spain); Finger, P.H.; Silva, B.A. da; Dallago, R.M.; Mignoni, M.L. [Universidade Regional Integrada do Alto Uruguai e das Missoes (URI), Erechim, RS (Brazil)

2016-07-01

Full text: Zeolites are crystalline tectosilicates constituted by (TO4) tetrahedra connected through the oxygens of their vertices. The importance of these materials is that their properties differ, due to their variable compositions and structures, leading to the possibility of applying them into different industries, for example, as catalyst in petroleum industry or sensors in quality control. One of the big questions in this area is about the understanding of the chemistry that directs to one or another type of zeolite. Another important question is the search of new zeolitic structures for new applications. One approach to answer both is the study of the structure-directing agents, which are inorganic or organic molecules used in the synthesis of zeolites. New and already-used molecules have been studied within different synthesis conditions and different techniques, as characterization or computational studies. And several attempts of rationalization were and, still, will be performed. In this research, an imidazolium-based compound was studied in hydrothermal zeolite synthesis as organic structure-directing agent (OSDA). The products were obtained with Si/Al or Si/(Al+Zn) compositions, proved by ICP data. X-ray diffractograms showed two different zeolitic types: MFI and TON. It was observed that when Zn was present in the synthesis gel, pure MFI phases were able to appear. But in his absence, the products were all mixtures of MFI and TON zeolites. It was also possible to distinguish both phases by SEM micrographs, as MFI had brick-like shape and TON appeared as needles. The obtained zeolites were stable until 900°C minimum, as tested by a TG/DTG/DSC experiment. To prove that the chosen OSDA directed these structures, a CHN analysis was performed, resulting in integrity of the molecules inside the zeolitic pores and cavities. Finally, a rationale about the location and conformation of the OSDA was needed to understand these experimental results. So, it was

Directing factors affecting the synthesis of a MFI-type zeolite

International Nuclear Information System (INIS)

Vinaches, P.; Pergher, S.B.C.; Lopes, C.W.; Gomez-Hortiguela, L.; Finger, P.H.; Silva, B.A. da; Dallago, R.M.; Mignoni, M.L.

2016-01-01

Full text: Zeolites are crystalline tectosilicates constituted by (TO4) tetrahedra connected through the oxygens of their vertices. The importance of these materials is that their properties differ, due to their variable compositions and structures, leading to the possibility of applying them into different industries, for example, as catalyst in petroleum industry or sensors in quality control. One of the big questions in this area is about the understanding of the chemistry that directs to one or another type of zeolite. Another important question is the search of new zeolitic structures for new applications. One approach to answer both is the study of the structure-directing agents, which are inorganic or organic molecules used in the synthesis of zeolites. New and already-used molecules have been studied within different synthesis conditions and different techniques, as characterization or computational studies. And several attempts of rationalization were and, still, will be performed. In this research, an imidazolium-based compound was studied in hydrothermal zeolite synthesis as organic structure-directing agent (OSDA). The products were obtained with Si/Al or Si/(Al+Zn) compositions, proved by ICP data. X-ray diffractograms showed two different zeolitic types: MFI and TON. It was observed that when Zn was present in the synthesis gel, pure MFI phases were able to appear. But in his absence, the products were all mixtures of MFI and TON zeolites. It was also possible to distinguish both phases by SEM micrographs, as MFI had brick-like shape and TON appeared as needles. The obtained zeolites were stable until 900°C minimum, as tested by a TG/DTG/DSC experiment. To prove that the chosen OSDA directed these structures, a CHN analysis was performed, resulting in integrity of the molecules inside the zeolitic pores and cavities. Finally, a rationale about the location and conformation of the OSDA was needed to understand these experimental results. So, it was

Direct type gerbode defect with cleft in anterior mitral leaflet: A rarest of rare combination

Directory of Open Access Journals (Sweden)

Rakesh Jain

2016-01-01

Full Text Available A 15-year-old boy was evaluated for the new onset of dyspnea. He had no significant medical or surgical history. On echocardiography, he was found to have a direct communication between the left ventricle and the right atrium through the atrioventricular (AV septum (a rare type of Gerbode defect with an associated cleft in the anterior mitral leaflet. The combination of direct type Gerbode defect with the cleft of the anterior mitral leaflet is extremely rare.

Three-party quantum secret sharing of secure direct communication based on χ-type entangled states

International Nuclear Information System (INIS)

Yu-Guang, Yang; Wei-Feng, Cao; Qiao-Yan, Wen

2010-01-01

Based on χ-type entangled states and the two-step protocol [Deng F G, Long G L and Liu X S 2003 Phys. Rev. A 68 042317], a quantum secret sharing protocol of secure direct communication based on χ-type entangled states |χ 00 ) 3214 is proposed. Using some interesting entanglement properties of this state, the agent entirety can directly obtain the secret message from the message sender only if they collaborate together. The security of the scheme is also discussed. (general)

Die kliniese kindersielkundige as diagnostikus1

Directory of Open Access Journals (Sweden)

D. J. W. Strümpfer

1961-03-01

Full Text Available Die benaming „Kliniese Kindersielkunde” is nog onbekend en gevolglik betreklik onbemind. Dit is in 1951 die eerste keer gebruik. Die werk van die Kliniese Kindersielkunde is egter so oud as die werk van die algemene Kliniese Sielkunde, waarvan die geskiedenis gewoonlik teruggevoer word tot die begin van sielkundige toetsing vroeg in die tagtigerjare. Tot ’n aansienlike mate is hierdie vroeë werk op kinders uitgevoer, bv. dié van Galton en later die van Binet en Simon. Witmer het in 1896 die eerste sielkundige kliniek geopen en het ook die term „Kliniese Sielkunde” ingevoer; die meerderheid van sy pasiënte was egter ook kinders. Tot voor die Tweede Wêreldoorlog was klinies-sielkundige werk hoofsaaklik op kinders toegespits. Sedertdien het die kliniese sielkundige tot ’n belangrike mate toegetree tot die gebied van die diagnose en terapie van psigiese afwykings by volwassenes, tot so ’n mate dat in die gedagtes en geskrifte van baie werkers die terrein van die Kliniese Sielkunde byna tot werk met volwassenes beperk word.

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

DEFF Research Database (Denmark)

Chaturvedi, N.; Porta, M.; Klein, R.

2008-01-01

of retinopathy in type 1 diabetes. METHODS: Two randomised, double-blind, parallel-design, placebo-controlled trials were done in 309 centres worldwide. Participants with normotensive, normoalbuminuric type 1 diabetes without retinopathy were recruited to the DIRECT-Prevent 1 trial and those with existing...... retinopathy were recruited to DIRECT-Protect 1, and were assigned to candesartan 16 mg once a day or matching placebo. After 1 month, the dose was doubled to 32 mg. Investigators and participants were unaware of the treatment allocation status. The primary endpoints were incidence and progression......BACKGROUND: Results of previous studies suggest that renin-angiotensin system blockers might reduce the burden of diabetic retinopathy. We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression...

The Hausa Lexicographic Tradition

Directory of Open Access Journals (Sweden)

Roxana Ma Newman

2011-10-01

Full Text Available

Abstract: Hausa, a major language of West Africa, is one of the most widely studied languagesof Sub-Saharan Africa. It has a rich lexicographic tradition dating back some two centuries. Sincethe first major vocabulary published in 1843 up to the present time, almost 60 lexicographic works— dictionaries, vocabularies, glossaries — have been published, in a range of metalanguages, fromEnglish to Hausa itself. This article traces the historical development of the major studies accordingto their type and function as general reference works, specialized works, pedagogical works, andterminological works. For each work, there is a general discussion of its size, accuracy of the phonological,lexical, and grammatical information, and the adequacy of its definitions and illustrativematerial. A complete list of the lexicographic works is included.

Keywords: ARABIC, BILINGUAL LEXICOGRAPHY, DIALECTAL VARIANTS, DICTIONARIES,ENGLISH, ETYMOLOGIES, FRENCH, GERMAN, GLOSSARIES, GRAMMATICALCATEGORIES, HAUSA, LANGUAGE LEARNING, LOANWORDS, NEOLOGISMS, NIGER,NIGERIA, ORTHOGRAPHY, PHONETIC TRANSCRIPTION, PHONOLOGY, RUSSIAN, STANDARDDIALECT, STANDARDIZATION, TERMINOLOGY, VOCABULARIES, WEST AFRICA.

Opsomming: Die leksikografiese tradisie in Hausa. Hausa, 'n belangrike taal vanWes-Afrika, is een van die tale van Afrika suid van die Sahara wat die wydste bestudeer word. Dithet 'n ryk leksikografiese tradisie wat ongeveer twee eeue oud is. Van die eerste groot woordeboekwat in 1843 gepubliseer is tot die hede is ongeveer 60 leksikografiese werke — woordeboeke,naamlyste, woordelyste — gepubliseer in 'n reeks metatale van Engels tot Hausa self. Hierdie artikelgaan die historiese ontwikkeling van die groter studies aan die hand van hulle tipe en funksieas algemene naslaanwerke, gespesialiseerde werke, opvoedkundige werke, en terminologiesewerke na. Vir elke werk is daar 'n algemene bespreking oor sy grootte, akkuraatheid van die fonologiese,leksikale en

Work-Life Balance: A Study In The Petroleum Industry

Directory of Open Access Journals (Sweden)

Judy De Villiers

2003-11-01

’n Kwalitatiewe studie is onderneem om vas te stel hoe die werknemers van ’n maatskappy in die petroleumnywerheid die fenomeen van die werk-lewe ewewig definieer en ervaar, om die werkpleksdeterminante van ’n werk-lewe onewewigtigheid te identifiseer en om sekere oplossings vir die probleem aan die hand te doen. Dit is gevind dat werk-lewe ewewig ’n persoonlike saak is wat oor tyd en omstandighede varieer en die ervaarde onderliggende konflik na roloorladingsrolle en -inmenging verwys. Die mees betekenisvolle werk-lewe konflik tree na vore vanuit komplekse werkplekaangeleenthede, insluitende die bestuur van veranderings, toesighoudende en tegniese vaardighede, leierskap, rolle en aanspreeklikheid, asook kultuur. Oplossings om die werkpleksake aan te spreek, asook die ontwikkeling van individuele vaardighede om ’n ewewig teweeg te bring, word voorgestel.

Fine typing of methicillin-resistant Staphylococcus aureus isolates using direct repeat unit and staphylococcal interspersed repeat unit typing methods.

Science.gov (United States)

Ho, Cheng-Mao; Ho, Mao-Wang; Li, Chi-Yuan; Lu, Jang-Jih

2015-08-01

Methicillin-resistant Staphylococcus aureus (MRSA) typing is an important epidemiologic tool for monitoring trends and preventing outbreaks. However, the efficiency of various MRSA typing methods for each SCCmec MRSA isolate is rarely evaluated. A total of 157 MRSA isolates from four different regions in Taiwan were typed with five different molecular methods, including SCCmec typing, multilocus sequence typing (MLST), spa typing, mec-associated direct repeat unit (dru) copy number determination, and staphylococcal interspersed repeat unit (SIRU) profiling. There were four SCCmec types, eight MLST types, 15 spa types, 11 dru types, and 31 SIRU profiles. The most common type determined by each molecular typing method was SCCmec III (115 isolates, 73.2%), ST239 (99 isolates, 63.1%), t037 (107 isolates, 68.2%), 14 dru copies (76 isolates, 48.4%), and SIRU profile 3013722 (102 isolates, 65%), respectively. When using the combination of MLST, spa typing, and dru copy number, ST5-t002-4 (n = 8), ST239-t037-14 (n = 68), ST59-t437-9 (n = 9), and ST59-t437-11 (n = 6) were found to be the most common types of SCCmec types II (n = 9), III (n = 115), IV (n = 21), and VT (n = 11) isolates, respectively. SCCmec type III isolates were further classified into 11 dru types. Of the 21 SCCmec type IV isolates, 14 SIRU profiles were found. Seven SIRU patterns were observed in the 11 SCCmec type VT isolates. Different typing methods showed a similar Hunter-Gaston discrimination index among the 157 MRSA isolates. However, dru and SIRU typing methods had a better discriminatory power for SCCmec type III and SCCmec types IV and VT isolates, respectively, suggesting that dru and SIRU can be used to further type these isolates. Copyright © 2013. Published by Elsevier B.V.

Naar een dashboard duurzame inzetbaarheid

NARCIS (Netherlands)

Blatter, B.; Dorenbosch, L.; Keijzer, L.

2015-01-01

Vlaanderen kent de Monitor Werkbaar Werk als informatiebron over de kwaliteit van werk voor de Vlaamse Regering, sociale partners, werkgevers en andere arbeidsmarktpartijen. Nederland kent sinds 2010 een soortgelijk instrument: het Dashboard Duurzame Inzetbaarheid. In deze bijdrage zetten we het

Modulation of type I immediate and type IV delayed immunoreactivity using direct suggestion and guided imagery during hypnosis.

Science.gov (United States)

Zachariae, R; Bjerring, P; Arendt-Nielsen, L

1989-11-01

Cutaneous reactivity against histamine skin prick test (Type I) and purified tuberculin protein derivative (Mantoux reaction, Type IV) was studied in eight volunteers under hypnosis. Types I and IV immunoreactivity were modulated by direct suggestion (Type I) and guided imagery (Type IV). The volunteers were highly susceptible subjects, selected by means of the Harvard Group Scale of Hypnotic Susceptibility, Form A. When the volunteers underwent hypnotic suggestion to decrease the cutaneous reaction to histamine prick test, a significant (P less than 0.02) reduction of the flare reaction (area of erythema) was observed compared with control histamine skin prick tests. The wheal reaction did not respond to hypnotic suggestion. Neither wheal nor flare reaction could be increased in size by hypnotic suggestion compared with control histamine skin prick tests. A hypnotic suggestion of increasing the Type IV reaction on one arm and decreasing the reaction on the other revealed a significant difference in both erythema size (P less than 0.02) and palpable induration (P less than 0.01). In two cases the reactions were monitored by laser doppler blood flowmetry and skin thickness measurement by ultrasound. The difference between the suggested increased and decreased reaction was 19% for the laser doppler bloodflow (in favor of the augmented side), and 44% for the dermal infiltrate thickness. This study objectively supports the numerous uncontrolled case reports of modulation of immunoreactivity in allergic diseases involving both Type I and Type IV skin reactions following hypnotic suggestions.

77 FR 5998 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

Science.gov (United States)

2012-02-07

... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A... proposed to correct an unsafe condition for the specified products. The MCAI states: EADS-CASA received... address this condition, EADS-CASA has developed an engine condition control cable P/N 35-56382-0005 with...

Occupational hazard? The relationship between working conditions and fertility

NARCIS (Netherlands)

Begall, Katia Hildegard

2013-01-01

De arbeidsmarktparticipatie van vrouwen en moeders is tegenwoordig maatschappelijk geaccepteerd en vaak ook nodig om te zorgen voor voldoende inkomen. Er zijn veel studies verricht naar welke aspecten van werk bevorderlijk of juist hinderlijk zijn voor combinatie van werk en gezin. Deze studies

Noise, neoliberalism and Iain Sinclair

NARCIS (Netherlands)

Martin, N.

2012-01-01

Niall Martin onderzocht het werk van de Britse schrijver en filmmaker Iain Sinclair. Hij stelt dat het concept van ruis (noise), voortkomend uit de informatietheorie, een verhelderend kader biedt voor onderzoek naar het werk van Sinclair. Sinclair beschreef uitvoerig hoe Londen veranderde van

Oestrogen directly inhibits the cardiovascular L-type Ca2+ channel Cav1.2

International Nuclear Information System (INIS)

Ullrich, Nina D.; Koschak, Alexandra; MacLeod, Kenneth T.

2007-01-01

Oestrogen can modify the contractile function of vascular smooth muscle and cardiomyocytes. The negative inotropic actions of oestrogen on the heart and coronary vasculature appear to be mediated by L-type Ca 2+ channel (Ca v 1.2) inhibition, but the underlying mechanisms remain elusive. We tested the hypothesis that oestrogen directly inhibits the cardiovascular L-type Ca 2+ current, I CaL . The effect of oestrogen on I CaL was measured in Ca v 1.2-transfected HEK-293 cells using the whole-cell patch-clamp technique. The current revealed typical activation and inactivation profiles of nifedipine- and cadmium-sensitive I CaL . Oestrogen (50 μM) rapidly reduced I CaL by 50% and shifted voltage-dependent activation and availability to more negative potentials. Furthermore, oestrogen blocked the Ca 2+ channel in a rate-dependent way, exhibiting higher efficiency of block at higher stimulation frequencies. Our data suggest that oestrogen inhibits I CaL through direct interaction of the steroid with the channel protein

Comorbidity between Type 2 Diabetes and Depression in the Adult Population: Directions of the Association and Its Possible Pathophysiological Mechanisms

Directory of Open Access Journals (Sweden)

Line Iden Berge

2015-01-01

Full Text Available Type 2 diabetes and depression are regarded as comorbid conditions, and three possible directions of the association between the diseases can underlie this observation of comorbidity. First, common etiology can increase a person’s risk of both diseases; second, persons with type 2 diabetes have increased prevalence or risk of future development of depression; or third, persons with depression have increased prevalence or risk of development of type 2 diabetes. This review gives an overview over possible pathophysiological mechanisms for each of the directions of the association between type 2 diabetes and depression and further discusses epigenetics as an additional, direction independent approach. We argue that unspecific pathophysiological mechanisms involved in the stress response might, at least to some extent, explain each of the directions of the association between type 2 diabetes and depression, while changes in brain structure and function among persons with diabetes and possible increased risk of development of type 2 diabetes after use of antidepressant agents could represent more disease specific mechanisms underlying the comorbidity.

STS for minisatellite 33. 1 (D9S49): Direct typing by PCR

Energy Technology Data Exchange (ETDEWEB)

Armour, J.A.L.; Neumann, R.; Jeffreys, A.J. (Univ. of Leicester (United Kingdom))

1991-09-11

The minisatellite locus 33.1 was initially isolated from a human genomic library by hybridization screening with a tandem repeat probe. This locus has since been localized by somatic cell hybrid analysis and linkage mapping to the long arm of chromosome. PCR typing at this minisatellite locus has already been described in which PCR products were detected by hybridization. Here the authors describe the direct typing of this locus by PCR, a process which may also be used to generate a probe for use in Southern blot analysis of genomic DNA.

76 FR 10220 - Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by...

Science.gov (United States)

2011-02-24

... Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by Bombardier Inc. and de...-approved maintenance/inspection program identified in this AD, contact Viking Air Ltd., 9574 Hampden Road... Sec. 39.13 by adding the following new airworthiness directive (AD): 2011-05-02 Viking Air Limited...

75 FR 68185 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

Science.gov (United States)

2010-11-05

... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A...) that were, at that moment, defined in issue C of EADS-CASA document DT-0-C00-05001. That document has... implementation of the revised Fuel Airworthiness Limitations contained in issue D of EADS- CASA document DT-0-C00...

P J Hoedemaker: 'Wat ék bedoel, is die behoud van die kerk'

African Journals Online (AJOL)

Philippus Jacobus Hoedemaker, asoek die werk van W Balke (1985), Gunning en. Hoedemaker: Samen op weg. Gedurende 1989 het daar ook 'n wye reeks tydskrif- artikels oer Hoedemaker verskyn. Daarbenewens het 'n omvattende werk oor. Hoedemaker onder redakteurskap van G Abma en J de Bruijn (1989) verskyn.

Het motorrijwiel : handboek voor motor- en scooterrijders, motor- en scootermonteurs en -technici

NARCIS (Netherlands)

Seyffardt, A.L.W.

1961-01-01

INHOUD: 1. De werking van de motor ; 2. De hoofddelen van de motor ; 3. De kleppen en de klepbeweging ; 4. Balancering, de meercilinder motor ; 5. Bijzonderheden over de werking ; 6. De carburateur ; 7. De smering van de motor ; 8. De tweetaktmotor ; 9. De elektrische installatie ; 10. De

Current limiting characteristics of transformer type SFCL with coupled secondary windings according to its winding direction

Energy Technology Data Exchange (ETDEWEB)

Lim, Sung Hun [Dept. of Electrical Engineering, Soongsil University, Seoul (Korea, Republic of); Han, Tae Hee [Dept. of Aero Materials Engineering, Jungwon University, Goesan (Korea, Republic of)

2017-06-15

In this paper, the current limiting characteristics of the transformer type superconducting fault current limiter (SFCL) with the two coupled secondary windings due to its winding direction were analyzed. To analyze the dependence of transient fault current limiting characteristics on the winding direction of the additional secondary winding, the fault current limiting tests of the SFCL with an additional secondary winding, wound as subtractive polarity winding and additive polarity winding, were carried out. The time interval of quench occurrence between two superconducting elements comprising the transformer type SFCL with the additional secondary winding was confirmed to be affected by the winding direction of the additional secondary winding. In case of the subtractive polarity winding of the additional secondary winding, the time interval of the quench occurrence in two superconducting elements was shorter than the case of the additive polarity winding.

Current limiting characteristics of transformer type SFCL with coupled secondary windings according to its winding direction

International Nuclear Information System (INIS)

Lim, Sung Hun; Han, Tae Hee

2017-01-01

In this paper, the current limiting characteristics of the transformer type superconducting fault current limiter (SFCL) with the two coupled secondary windings due to its winding direction were analyzed. To analyze the dependence of transient fault current limiting characteristics on the winding direction of the additional secondary winding, the fault current limiting tests of the SFCL with an additional secondary winding, wound as subtractive polarity winding and additive polarity winding, were carried out. The time interval of quench occurrence between two superconducting elements comprising the transformer type SFCL with the additional secondary winding was confirmed to be affected by the winding direction of the additional secondary winding. In case of the subtractive polarity winding of the additional secondary winding, the time interval of the quench occurrence in two superconducting elements was shorter than the case of the additive polarity winding

Nonimaging compound parabolic concentrator-type reflectors with variable extreme direction.

Science.gov (United States)

Gordon, J M; Rabl, A

1992-12-01

The properties of nonimaging compound parabolic concentrator (CPC)-type devices are examined in which the extreme direction is not constant but rather is a variable that can change along the reflector. One can then retain the maximal concentration or radiative efficiency of the CPC while the flux map on the absorber or target is modified, depending on whether the device is used for optical concentration or for lighting. Two general classes of reflector are derived, and all the nonimaging devices developed to date are shown to be special cases of the general solution. These two classes are the nonimaging analog of converging and diverging devices of imaging optics.

Invloed van minerale olie op de bestrijding van Phytophthora infestans in pootaardappelen

NARCIS (Netherlands)

Spits, H.G.; Bus, C.B.

2003-01-01

De invloed van toevoeging van olie aan een fungicide op de werking van het fungicide is afhankelijk van het gebruikte fungicide. Gezamenlijk spuiten van olie en Aviso DF, Curzate M en mogelijk ook Acrobat, verhoogt de curatieve werking van deze fungiciden. Gezamenlijk spuiten van olie en Aviso DF,

Actuele en opkomende VGW-problemen in de gezondheidszorg, waaronder thuis- en gemeenschapszorg : Europese waarnemingspost voor risico's

NARCIS (Netherlands)

Jong, T. de; Bos, E.; Pawlowska-Cyprysiak, K.; Hildt-Ciupińska, K.; Malińska, M.; Nicolescu, G.; Trifu, A.

2014-01-01

Deze samenvatting biedt een overzicht van de actuele en opkomende problemen qua veiligheid en gezondheid op het werk (VGW) voor werknemers in de gezondheids- en maatschappelijke zorg en laat zien wat de gevolgen hiervan zijn voor hun veiligheid en gezondheid op het werk en voor de kwaliteit van de

Sharing is Caring

DEFF Research Database (Denmark)

Sanderhoff, Merete

2015-01-01

70 Jahre nach dem Tod eines Urhebers werden dessen Werke zu öffentlichem geistigem Eigentum, sie sind gemeinfrei und gehören somit dem Publikum. Damit sind nicht nur mittelalterliche Texte, sondern auch Bücher und Werke aus dem 20. Jahrhundert frei. Die Digitalisierung hat dem Umgang mit diesen...

77 FR 33622 - Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by...

Science.gov (United States)

2012-06-07

... Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by Alpha Aviation... Aviation Concept Limited Model R2160 Airplanes. This AD results from mandatory continuing airworthiness... condition on an aviation product. The MCAI describes the unsafe condition as oil lines fitted to affected...

Typing DNA profiles from previously enhanced fingerprints using direct PCR.

Science.gov (United States)

Templeton, Jennifer E L; Taylor, Duncan; Handt, Oliva; Linacre, Adrian

2017-07-01

Fingermarks are a source of human identification both through the ridge patterns and DNA profiling. Typing nuclear STR DNA markers from previously enhanced fingermarks provides an alternative method of utilising the limited fingermark deposit that can be left behind during a criminal act. Dusting with fingerprint powders is a standard method used in classical fingermark enhancement and can affect DNA data. The ability to generate informative DNA profiles from powdered fingerprints using direct PCR swabs was investigated. Direct PCR was used as the opportunity to generate usable DNA profiles after performing any of the standard DNA extraction processes is minimal. Omitting the extraction step will, for many samples, be the key to success if there is limited sample DNA. DNA profiles were generated by direct PCR from 160 fingermarks after treatment with one of the following dactyloscopic fingerprint powders: white hadonite; silver aluminium; HiFi Volcano silk black; or black magnetic fingerprint powder. This was achieved by a combination of an optimised double-swabbing technique and swab media, omission of the extraction step to minimise loss of critical low-template DNA, and additional AmpliTaq Gold ® DNA polymerase to boost the PCR. Ninety eight out of 160 samples (61%) were considered 'up-loadable' to the Australian National Criminal Investigation DNA Database (NCIDD). The method described required a minimum of working steps, equipment and reagents, and was completed within 4h. Direct PCR allows the generation of DNA profiles from enhanced prints without the need to increase PCR cycle numbers beyond manufacturer's recommendations. Particular emphasis was placed on preventing contamination by applying strict protocols and avoiding the use of previously used fingerprint brushes. Based on this extensive survey, the data provided indicate minimal effects of any of these four powders on the chance of obtaining DNA profiles from enhanced fingermarks. Copyright © 2017

Anfangen, sich die Welt anders vorzustellen

Directory of Open Access Journals (Sweden)

Sabine Fuchs

2006-11-01

Full Text Available Der Sammelband Butler Matters bezeugt Judith Butlers außerordentliche Bedeutung für feministische und queere Studien und Forschung. In elf Beiträgen wird Butlers (frühes Werk von Gender Trouble und Bodies That Matter über Excitable Speech bis zu The Psychic Life of Power betrachtet und sein weit reichender Einfluss quer durch die wissenschaftlichen Disziplinen nachgewiesen. Dargestellt werden auch die kontroverse Rezeption von Butlers Werk sowie die politischen Wirkungen von Butlers Denken. Besonders anregend ist ein zweiteiliges Interview mit Judith Butler, in dem sie auf ein breites Spektrum von Fragen eingeht, die auch wichtige Themen ihrer aktuelleren Werke betreffen.

34 Resensie Fourie WEB 03.pmd

African Journals Online (AJOL)

Owner

In 2009 verskyn Louise Viljoen se bundel opstelle, Ons ongehoorde soort: Beskouings oor die werk van Antjie Krog. Dié publikasie getuig duidelik van 'n navorser wat 'n lewenslange belangstelling in die werk van een digter noukeurig uitgebou het tot 'n formidabele kritiese beskouing oor een van Afrikaans se veelsydigste ...

77 FR 15980 - Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by...

Science.gov (United States)

2012-03-19

... Concept Limited (Type Certificate Previously Held by Alpha Aviation Design Limited) Airplanes AGENCY... rulemaking (NPRM). SUMMARY: We propose to adopt a new airworthiness directive (AD) for Alpha Aviation Concept... condition on an aviation product. The MCAI describes the unsafe condition as oil lines fitted to affected...

Differential loggerhead by-catch and direct mortality due to surface longlines according to boat strata and gear type

Directory of Open Access Journals (Sweden)

Juan A. Camiñas

2006-12-01

Full Text Available Surface longline gears are used to fish different species, mainly albacore Thunnus alalunga (Bonnaterre, 1788, bluefin tuna Thunnus thynnus (Linnaeus, 1758, and swordfish Xiphias gladius Linnaeus, 1758, and are considered highly dangerous for threatened marine turtles. Loggerheads Caretta caretta (Linnaeus, 1758 can be incidentally captured by surface longlines. A number of captured individuals die during the fishing operation, which we consider direct mortality due to fishing. We analysed the relative loggerhead by-catch and direct mortality associated with each type of boat and gear from April to December during the period 1999-2004 in the Spanish surface longline fleet that fishes in the western Mediterranean Sea, an important fishing area for this fleet. We used different indices to compute the catch per unit effort (CPUE according to the number of hooks and to the number of fishing operations for each type of boat and gear. Both by-catch and direct mortality differed significantly according to the type of boat and gear. With respect to the number of hooks, boats longer than 12 m not using a roller and targeting bluefin tuna captured the highest number of loggerheads, whereas boats longer than 12 m with a roller that targeted swordfish caused the highest direct mortality. With respect to the number of fishing operations, boats longer than 12 m without a roller that targeted albacore captured the highest number of loggerheads; the highest direct mortality was caused by this type of boat and by boats longer than 12 m using a roller and targeting swordfish.

CATS Aerosol Typing and Future Directions

Science.gov (United States)

McGill, Matt; Yorks, John; Scott, Stan; Palm, Stephen; Hlavka, Dennis; Hart, William; Nowottnick, Ed; Selmer, Patrick; Kupchock, Andrew; Midzak, Natalie;

Emission Scenario Document for Biocides Emission scenarios for all 23 product types of the Biocidal Products Directive (EU Directive 98/8/EC)

NARCIS (Netherlands)

Poel P van der; Bakker J; CSR

2002-01-01

This report presents an overview of all available emission scenarios for all 23 product types of biocides according to EU Directive 98/8/EC. The scenarios presented are already present in USES 3.0 or have been reported by RIVM or within the scope of the project "Gathering, review and development of

Resensies/Reviews 294 book without feeling overwhelmed by the ...

African Journals Online (AJOL)

uitgegee word, is om verskeie redes heel gepas. Eerstens is die boek 'n goeie uitdrukking van Brümmer se oevre en werk. Hy beklemtoon deur- gaans hierin die belangrikheid daarvan dat ons met geen ewige, tydlose, gestolde, geslote waarheid werk nie, maar dat ons in 'n dinamiese proses onderweg is om voortdurend ...

Redaksioneel

African Journals Online (AJOL)

LouwnaVanHeerden

daar narratiewe paradigmas na vore gekom het vir die lees van vertel- tekste. Die kritiese paradigma wat ook bekend staan as die meganiese paradigma, opereer deur 'n werk in dele op te breek, kousale en gene- tiese oorspronge daarvan te probeer vasstel en die geskiedenis van die vorming van die werk te probeer ...

as by die huisbesoek. HP WOLMARANS. PROF. DR. SP ...

African Journals Online (AJOL)

Test

van 'n evangeüedienaar wat alles fei! gehad het vir die werk en werk kring waartoe God hom geroep het. Hy is dan ook werklik die eerste grondlegger van die gemeente in Zoutpansberg en die man wat dit opgewerk het. Die geskiedenis van Hofmeyer is die geskiedenis van die kerk- vereniging en die redes waarom die ...

C-type Lectin Receptors for Tumor Eradication: Future Directions

Energy Technology Data Exchange (ETDEWEB)

Streng-Ouwehand, Ingeborg; Unger, Wendy W. J.; Kooyk, Yvette van, E-mail: y.vankooyk@vumc.nl [Department of Molecular Cell Biology and Immunology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam (Netherlands)

2011-08-08

Dendritic cells are key regulators in directing immune responses and therefore are under extensive research for the induction of anti-tumor responses. DCs express a large array of receptors by which they scan their surroundings for recognition and uptake of pathogens. One of the receptor-families is the C-type lectins (CLR), which bind carbohydrate structures and internalize antigens upon recognition. Intracellular routing of antigen through CLR enhances loading and presentation of antigen through MHC class I and II, inducing antigen-specific CD4{sup +} and CD8{sup +} T-cell proliferation and skewing T-helper cells. These characteristics make CLRs very interesting targets for DC-based immunotherapy. Profound research has been done on targeting specific tumor antigens to CLR using either antibodies or the natural ligands such as glycan structures. In this review we will focus on the current data showing the potency of CLR-targeting and discuss improvements that can be achieved to enhance anti-tumor activity in the near future.

Direct Repeat Unit (dru) Typing of Methicillin-Resistant Staphylococcus pseudintermedius from Dogs and Cats.

Science.gov (United States)

Kadlec, Kristina; Schwarz, Stefan; Goering, Richard V; Weese, J Scott

2015-12-01

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged in a remarkable manner as an important problem in dogs and cats. However, limited molecular epidemiological information is available. The aims of this study were to apply direct repeat unit (dru) typing in a large collection of well-characterized MRSP isolates and to use dru typing to analyze a collection of previously uncharacterized MRSP isolates. Two collections of MRSP isolates from dogs and cats were included in this study. The first collection comprised 115 well-characterized MRSP isolates from North America and Europe. The data for these isolates included multilocus sequence typing (MLST) and staphylococcal protein A gene (spa) typing results as well as SmaI macrorestriction patterns after pulsed-field gel electrophoresis (PFGE). The second collection was a convenience sample of 360 isolates from North America. The dru region was amplified by PCR, sequenced, and analyzed. For the first collection, the discriminatory indices of the typing methods were calculated. All isolates were successfully dru typed. The discriminatory power for dru typing (D = 0.423) was comparable to that of spa typing (D = 0.445) and of MLST (D = 0.417) in the first collection. Occasionally, dru typing was able to further discriminate between isolates that shared the same spa type. Among all 475 isolates, 26 different dru types were identified, with 2 predominant types (dt9a and dt11a) among 349 (73.4%) isolates. The results of this study underline that dru typing is a useful tool for MRSP typing, being an objective, standardized, sequence-based method that is relatively cost-efficient and easy to perform. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Synthesis of metalloporphyrin-based conjugated microporous polymer spheres directed by bipyridine-type ligands.

Science.gov (United States)

Ji, Guipeng; Yang, Zhenzhen; Zhao, Yanfei; Zhang, Hongye; Yu, Bo; Xu, Jilei; Xu, Huanjun; Liu, Zhimin

2015-04-30

Zinc porphyrin (TP-Zn)-based conjugated microporous polymer (Zn-CMP) spheres were obtained via Sonagashira-Hagihara cross coupling reactions between 5,10,15,20-tetrakis(4-ethynylphenyl)porphyrin-Zn(II) and brominated monomers directed by bidentate bipyridine (BP)-type ligands for the first time, and the sphere diameters could be adjusted from 320 to 740 nm. The coordination between BP and TP-Zn was proved to be the key to forming spheres.

Inner-Directed and Other-Directed Values of Professional Journalists.

Science.gov (United States)

Schwartz, Stuart H.

1978-01-01

Reports that an analysis of the responses of 35 journalists to 50 value items revealed two types of journalists: the inner-directed high professional and the other-directed low professional. Discusses attitudes and values of the two types. (GT)

Type-Directed Elaboration of Quasiquotations

DEFF Research Database (Denmark)

Christiansen, David Raymond

2014-01-01

Idris's reflection features allow Idris metaprograms to manipulate a representation of Idris's core language as a datatype, but these reflected terms were designed for ease of type checking and are therefore exceedingly verbose and tedious to work with. A simpler notation would make these programs...

Are Participants Aware of the Type and Intensity of Transcranial Direct Current Stimulation?

Directory of Open Access Journals (Sweden)

Matthew F Tang

Full Text Available Transcranial direct current stimulation (tDCS is commonly used to alter cortical excitability but no experimental study has yet determined whether human participants are able to distinguish between the different types (anodal, cathodal, and sham of stimulation. If they can then they are not blind to experimental conditions. We determined whether participants could identify different types of stimulation (anodal, cathodal, and sham and current strengths after experiencing the sensations of stimulation during current onset and offset (which are associated with the most intense sensations in Experiment 1 and also with a prolonged period of stimulation in Experiment 2. We first familiarized participants with anodal, cathodal, and sham stimulation at both 1 and 2 mA over either primary motor or visual cortex while their sensitivity to small changes in visual stimuli was assessed. The different stimulation types were then applied for a short (Experiment 1 or extended (Experiment 2 period with participants indicating the type and strength of the stimulation on the basis of the evoked sensations. Participants were able to identify the intensity of stimulation with shorter, but not longer periods, of stimulation at better than chance levels but identification of the different stimulation types was at chance levels. This result suggests that even after exposing participants to stimulation, and ensuring they are fully aware of the existence of a sham condition, they are unable to identify the type of stimulation from transient changes in stimulation intensity or from more prolonged stimulation. Thus participants are able to identify intensity of stimulation but not the type of stimulation.

Direct Lactamization of Azido Amides via Staudinger-Type Reductive Cyclization

Energy Technology Data Exchange (ETDEWEB)

Heo, In Jung; Lee, Su Jeong; Cho, Chang Woo [Kyungpook National University, Daegu (Korea, Republic of)

2012-01-15

The direct lactamization of 1,3- and 1,4-azido amides has been achieved using triphenylphosphine and water, affording various γ- and δ-lactams in good to excellent yields. The direct lactamization of the azido amides was performed via the Staudinger-type reductive cyclization in which the amide group acts as the electrophile for lactam synthesis. This lactamization provides a mild, functional group tolerant and efficient route for the synthesis of various γ- and δ-lactams found in natural products and pharmaceuticals. Further studies will be conducted to develop new synthetic routes for the synthesis of various lactams. The lactam ring system is one of the most ubiquitous structural motifs found in natural products and pharmaceuticals. Owing to the prevalence of lactams, their synthesis has attracted considerable attention. Lactams are usually prepared by the coupling of activated carboxylic acid derivatives with amines. Alternative routes include the Beckmann rearrangement of oximes, the Schmidt reaction of cyclic ketones and hydrazoic acid, the Kinugasa reaction of nitrones and terminal acetylenes, the Diels-Alder reaction of cyclopentadiene and chlorosulfonyl isocyanate, transition metal catalyzed lactamization of amino alcohols, and iodolactamization of amides and alkenes. In particular, the intramolecular Staudinger ligation of azides and activated carboxy acids, including esters, is well known as an environmentally friendly and mild protocol for lactam synthesis.

Direct Lactamization of Azido Amides via Staudinger-Type Reductive Cyclization

International Nuclear Information System (INIS)

Heo, In Jung; Lee, Su Jeong; Cho, Chang Woo

2012-01-01

The direct lactamization of 1,3- and 1,4-azido amides has been achieved using triphenylphosphine and water, affording various γ- and δ-lactams in good to excellent yields. The direct lactamization of the azido amides was performed via the Staudinger-type reductive cyclization in which the amide group acts as the electrophile for lactam synthesis. This lactamization provides a mild, functional group tolerant and efficient route for the synthesis of various γ- and δ-lactams found in natural products and pharmaceuticals. Further studies will be conducted to develop new synthetic routes for the synthesis of various lactams. The lactam ring system is one of the most ubiquitous structural motifs found in natural products and pharmaceuticals. Owing to the prevalence of lactams, their synthesis has attracted considerable attention. Lactams are usually prepared by the coupling of activated carboxylic acid derivatives with amines. Alternative routes include the Beckmann rearrangement of oximes, the Schmidt reaction of cyclic ketones and hydrazoic acid, the Kinugasa reaction of nitrones and terminal acetylenes, the Diels-Alder reaction of cyclopentadiene and chlorosulfonyl isocyanate, transition metal catalyzed lactamization of amino alcohols, and iodolactamization of amides and alkenes. In particular, the intramolecular Staudinger ligation of azides and activated carboxy acids, including esters, is well known as an environmentally friendly and mild protocol for lactam synthesis

Diffraction by one and two direction periodic antiphase of the AuCu{sub 3} type; Diffraction par les antiphases periodiques a une et deux directions du type AuCu{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Perio, P.; Tournarie, M. [Commissariat a l' energie atomique et aux energies alternatives - CEA, Centre d' Etudes nucleaires de Saclay (France)

1960-07-01

A theory is presented describing the diffraction by periodic antiphase structure in ordered AuCu{sub 3} type alloys. The treatment is rigorous and allows for non-integer periods. The general shape of the amplitude distribution in any 00ι reciprocal plane can be determined without any computation and is given for the six possible configurations of two direction antiphase structures. Reprint of a paper published in Acta Crystallographica, Vol. 12, Part 12, 1959, p. 1032-1038.

Direct medical cost of type 2 diabetes in singapore.

Directory of Open Access Journals (Sweden)

Charmaine Shuyu Ng

Full Text Available Due to the chronic nature of diabetes along with their complications, they have been recognised as a major health issue, which results in significant economic burden. This study aims to estimate the direct medical cost associated with type 2 diabetes mellitus (T2DM in Singapore in 2010 and to examine both the relationship between demographic and clinical state variables with the total estimated expenditure. The National Healthcare Group (NHG Chronic Disease Management System (CDMS database was used to identify patients with T2DM in the year 2010. DM-attributable costs estimated included hospitalisations, accident and emergency (A&E room visits, outpatient physician visits, medications, laboratory tests and allied health services. All charges and unit costs were provided by the NHG. A total of 500 patients with DM were identified for the analyses. The mean annual direct medical cost was found to be $2,034, of which 61% was accounted for by inpatient services, 35% by outpatient services, and 4% by A&E services. Independent determinants of total costs were DM treatments such as the use of insulin only (p<0.001 and the combination of both oral medications and insulin (p=0.047 as well as having complications such as cerebrovascular disease (p<0.001, cardiovascular disease (p=0.002, peripheral vascular disease (p=0.001, and nephropathy (p=0.041. In this study, the cost of DM treatments and DM-related complications were found to be strong determinants of costs. This finding suggests an imperative need to address the economic burden associated with diabetes with urgency and to reorganise resources required to improve healthcare costs.

Direct view panel type X-ray image intensifier tube

International Nuclear Information System (INIS)

Yang, S.-P.; Robbins, C.D.; Merrit, E.

1977-01-01

A panel shaped, proximity type, X-ray image intensifier tube for medical X-ray fluoroscopy use is described. It has all linear components and yet a high brightness gain, in excess of 4,000 cd-sec/m 2 -R, the tube being comprised of a rugged metallic tube envelope, an inwardly concave metallic input window, a directly viewable full size output display screen, and a scintillator-photocathode screen having a thickness of at least 200 microns for a high X-ray photon utilization ability as well as X-ray stopping power, the scintillator-photocathode screen being suspended on insulators within the envelope and in between the input window and the output screen. The scintillator-photocathode screen is spaced from the output screen by at least 8mm to allow the application of a high negative potential at the scintillator-photocathode screen with respect to the output screen for high gain with low field emission, since all of the remaining components within the tube envelope are at neutral potential with respect to the output display screen. (Auth.)

Expertisediversiteit en teaminnovativiteit : De modererende werking van taakafhankelijkheid en taakflexibiliteit

NARCIS (Netherlands)

van der Vegt, G.S.

In this article we examine the joint effects of expertise diversity, task interdependence, and task flexibility on team innovation. We argue that expertise diversity will be unrelated to team innovation when task interdependence is low. When task interdependence is high, the direction of the

COPD en werk.

NARCIS (Netherlands)

Houtum, L. van; Heijmans, M.

2010-01-01

Drie van de vijf mensen met chronisch obstructieve longziekte werkt niet. In veel gevallen is hun longziekte hiervan de oorzaak, zo blijkt uit de Astma-/COPD-monitor. In Nederland hebben 320.000 mensen de diagnose chronisch obstructieve longziekte (COPD). Daarnaast zijn er nog eens zo’n 300.000

Direct diabetes-related costs in young patients with early-onset, long-lasting type 1 diabetes.

Directory of Open Access Journals (Sweden)

Christina Bächle

Full Text Available OBJECTIVE: To estimate diabetes-related direct health care costs in pediatric patients with early-onset type 1 diabetes of long duration in Germany. RESEARCH DESIGN AND METHODS: Data of a population-based cohort of 1,473 subjects with type 1 diabetes onset at 0-4 years of age within the years 1993-1999 were included (mean age 13.9 (SD 2.2 years, mean diabetes duration 10.9 (SD 1.9 years, as of 31.12.2007. Diabetes-related health care services utilized in 2007 were derived from a nationwide prospective documentation system (DPV. Health care utilization was valued in monetary terms based on inpatient and outpatient medical fees and retail prices (perspective of statutory health insurance. Multiple regression models were applied to assess associations between direct diabetes-related health care costs per patient-year and demographic and clinical predictors. RESULTS: Mean direct diabetes-related health care costs per patient-year were €3,745 (inter-quartile range: 1,943-4,881. Costs for glucose self-monitoring were the main cost category (28.5%, followed by costs for continuous subcutaneous insulin infusion (25.0%, diabetes-related hospitalizations (22.1% and insulin (18.4%. Female gender, pubertal age and poor glycemic control were associated with higher and migration background with lower total costs. CONCLUSIONS: Main cost categories in patients with on average 11 years of diabetes duration were costs for glucose self-monitoring, insulin pump therapy, hospitalization and insulin. Optimization of glycemic control in particular in pubertal age through intensified care with improved diabetes education and tailored insulin regimen, can contribute to the reduction of direct diabetes-related costs in this patient group.

‘Das politische Welträtsel’: Ernst Haeckel en het Duitse liberalisme 1859-1900

Directory of Open Access Journals (Sweden)

Daan Wegener

2011-09-01

Full Text Available Het werk van de evolutionair-morfoloog en wetenschapspopularisator Ernst Haeckel is uiterst omstreden. Zijn sociaaldarwinisme is na de Tweede Wereldoorlog om begrijpelijke redenen in een kwaad daglicht komen te staan. De meest expliciete veroordeling van Haeckel is waarschijnlijk Daniel Gasmans The Scientific Origins of National Socialism in Ernst Haeckel. Inmiddels hebben wetenschapshistorici het eenzijdig negatieve beeld genuanceerd. Volgens de standaardkritiek is het anachronistisch om latere ontwikkelingen terug te projecteren op het werk van Haeckel. Zo ziet Robert Richards in Haeckel geen voorloper van het nazisme, maar een late vertegenwoordiger van een Duitse romantische traditie, die teruggaat op Alexander von Humboldt en Goethe. Met andere woorden Richards is meer geïnteresseerd in de intellectuele achtergronden, dan in de politieke en culturele werking van Haeckels denken.

Direct Imaging Discovery of a "Super-Jupiter" around the Late B-type Star κ And

NARCIS (Netherlands)

Carson, J.; et al., [Unknown; Thalmann, C.

2013-01-01

We present the direct imaging discovery of an extrasolar planet, or possible low-mass brown dwarf, at a projected separation of 55 ± 2 AU (1.''058 ± 0.''007) from the B9-type star κ And. The planet was detected with Subaru/HiCIAO during the SEEDS survey and confirmed as a bound companion via common

Clinical evaluation of digital angiographic system equipped with the Safire' flat-panel detector of a direct conversion type

International Nuclear Information System (INIS)

Miura, Yoshiaki; Miura, Yusuke; Goto, Keiichi

2003-01-01

This report presents a report on clinical evaluation of our newly developed flat-panel X-ray detector of a direct conversion type, designed to provide images of a resolution higher than, or at least equal to, that ensured by X-ray photographic films, in clinical digital X-ray cinematography. This new detector was named 'Safire' the acronym of 'Shimadzu advanced flat imaging receptor', emphasizing its high technological level, such as the capability to ensure high quality of images. The clinical evaluation of Shimadzu DIGITEX Premier digital angiography system, equipped with this new flat-panel X-ray detector of a direct conversion type, has been started in March, 2003, at the Kokura Memorial Hospital in Kyushu, Japan. (author)

Type II textured molybdenum disulphide films produced by direct vapour transport and rf-magnetron sputtering

International Nuclear Information System (INIS)

Bohlken, S.F.; Lemon, K.D.; Jakovidis, G.; Taheri, E.H.

1999-01-01

Full text: Molybdenum disulphide (MoS 2 ) is one of the few naturally occurring Layered Transition Metal Dichalcogenides and is the primary source for elemental molybdenum. It displays exceptional lubrication performance in both vacuum and atmospheric conditions over a wide temperature range. An important emerging application of MoS 2 and related materials is photovoltaics. Films of MoS 2 exhibit several morphologies described by the orientation of platelets with respect to the substrate. Films with platelets perpendicular or parallel to the substrate are referred to by their morphology, which is type-I or type-II respectively. Production of exclusive type-II films is highly desirable in applications involving lubrication and photovoltaics. For example, type-II morphology reduces friction and minority carrier recombination centres, thus improving tribological and photovoltaic performance. We have successfully produced type-II films using both direct vapour transport and rf-magnetron sputtering Continuous polycrystalline films (∼ 10 μm thick) grown in our laboratory using vapour transport have typical areas 1000 mm 2 . A novel ejecta filtration technique was applied to rf-magnetron sputtering. Films produced using this approach retain exclusive type-II morphology at thicknesses where type-I would normally be observed (∼ 200nm)

76 FR 62605 - Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes With Supplemental Type...

Science.gov (United States)

2011-10-11

... Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes With Supplemental Type Certificate.... That AD applies to Viking Air Limited Model DHC-3 (Otter) airplanes equipped with a Honeywell TPE331... limitations and marking the airspeed indicator accordingly for Viking Air Limited Model DHC-3 (Otter...

Novel Naphthalene Based Lariat-Type Crown Ethers Using Direct Single Electron Transfer Photochemical Strategy

International Nuclear Information System (INIS)

Park, Hea Jung; Sung, Nam Kyung; Kim, Su Rhan; Kim, Su Rhan; Ahn, So Hyun; Yoon, Ung Chan; Cho, Dae Won; Mariano, Patrick S.

2013-01-01

This study explored a direct SET-photochemical strategy to construct a new family of thioene conjugated-naphthalamide fluorophore based lariat-crown ethers which show strong binding properties towards heavy metal ions. Irradiations of designed nitrogen branched (trimethylsilyl)methylthio-terminated polyethylenoxy-tethered naphthalimides in acidic methanol solutions have led to highly efficient photocyclization reactions to generate naphthalamide based lariat type thiadiazacrown ethers directly in chemo- and regio-selective manners which undergo very facile secondary dehydration reactions during separation processes to produce their corresponding amidoenethio ether cyclic products tethered with electron donating diethyleneoxy- and diethyenethio-side arm chains. Fluorescence and metal cation binding properties of the lariat type enamidothio products were examined. The photocyclized amidoenethio products, thioene conjugated naphthalamide fluorophore containing lariat-thiadiazacrowns exhibited strong fluorescence emissions in region of 330-450 nm along with intramolecular exciplex emissions in region of 450-560 nm with their maxima at 508 nm. Divalent cation Hg 2+ and Pb 2+ showed strong binding to sulfur atom(s) in side arm chain and atoms in enethiadiazacrown ether rings which led to significant enhancement of fluorescence from its chromophore singlet excited state and concomitant quenching of exciplex emission. The dual fluorescence emission responses towards divalent cations might provide a new guide for design and development of fluorescence sensors for detecting those metals

Optimal conditions in direct dimethyl ether synthesis from syngas utilizing a dual-type fluidized bed reactor

International Nuclear Information System (INIS)

Yousefi, Ahmad; Eslamloueyan, Reza; Kazerooni, Nooshin Moradi

2017-01-01

Concerns over environmental pollution and ever-increasing energy demand have urged the global community to tap clean-burning fuels among which dimethyl ether is a promising candidate for contribution in the transportation sector. Direct dimethyl ether synthesis from syngas, in which methanol production and dehydration take place simultaneously, is arguably the preferred route for large scale production. In this study, direct dimethyl ether synthesis is proposed in an industrial dual-type fluidized bed reactor. This configuration involves two fluidized bed reactors operating in different conditions. In the first catalytic reactor (water-cooled reactor), the synthesis gas is partly converted to methanol after being preheated by the reaction heat in the second reactor (gas-cooled reactor). A two-phase generalized comprehensive reactor model, comprised of the flow in three different regimes is applied and a smooth transition between flow regimes is provided based on the probabilistic averaging approach. The optimal operating conditions are sought by employing differential evolution algorithm as a robust optimization strategy. The dimethyl ether mole fraction is considered as the objective function during the optimization. The results show considerable dimethyl ether enhancement by 16% and 14% compared to the conventional direct dimethyl ether synthesis reactor and dual-type fixed bed dimethyl ether reactor arrangements, respectively. - Highlights: • Dual-type catalytic fluidized bed reactors for dimethyl ether synthesis is studied. • A two-phase comprehensive model comprised of flow in three regimes is used. • Probabilistic averaging approach is applied for smooth transitions between regimes. • Differential evolution method is employed to determine optimal operating conditions. • Production capacity is remarkably enhanced compared to conventional reactor.

Sleep duration and subjective psychological well-being in adolescence: a longitudinal study in Switzerland and Norway

OpenAIRE

Brand, Serge; Lemola,Sakari; Holsboer-Trachsler,Edith; Grob,Alexander; Kalak,Nadeem

2014-01-01

Nadeem Kalak,1 Sakari Lemola,2 Serge Brand,1,3 Edith Holsboer–Trachsler,1 Alexander Grob21Center for Affective, Stress and Sleep Disorder, Psychiatric Hospital of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland; 2Department of Psychology, 3Department of Sport and Health Science, Division of Sport Science, University of Basel, Basel, Switzerland Background: Adolescents’ sleep duration and subjective psychological well-being are...

Normzahlen, Toleranzen, Passungen

Science.gov (United States)

Böge, Gert; Böge, Wolfgang

Vor allem wegen der Kosten ist es sinnvoll, sich beim Festlegen von Maßen aller Art auf Vorzugszahlen zu beschränken (Baugrößen, Drehzahlen, Drehmomente, Leistungen, Drücke usw.). Man verwendet dazu eine geometrisch gestufte Zahlenfolge (siehe Teil Mathematik). Abb. 40.1 zeigt, dass bei der geometrischen Stufung die Werte im unteren Bereich fein, im oberen grob gestuft sind. Das ist nicht nur technisch sinnvoll.

76 FR 34011 - Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by...

Science.gov (United States)

2011-06-10

...-0597; Directorate Identifier 2011-CE-019-AD] RIN 2120-AA64 Airworthiness Directives; Viking Air Limited.../inspection program identified in this AD, contact Viking Air Ltd., 9574 Hampden Road, Sidney, BC Canada V8L... 2011-05-02, Amendment 39-16611 (76 FR 10220, February 24, 2011), for certain Viking Air Limited (Type...

76 FR 18033 - Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper...

Science.gov (United States)

2011-04-01

... Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper Aircraft, Inc... applies to certain Piper Aircraft, Inc. Models PA-46-310P and PA- 46-350P airplanes that are equipped with... information identified in this AD, contact Piper Aircraft, Inc., 2926 Piper Drive, Vero Beach, Florida 32960...

Novel Naphthalene Based Lariat-Type Crown Ethers Using Direct Single Electron Transfer Photochemical Strategy

Energy Technology Data Exchange (ETDEWEB)

Park, Hea Jung; Sung, Nam Kyung; Kim, Su Rhan; Kim, Su Rhan; Ahn, So Hyun; Yoon, Ung Chan [Pusan National Univ., Busan (Korea, Republic of); Cho, Dae Won [Yeungnam Univ., Geoungsan (Korea, Republic of); Mariano, Patrick S. [Univ. of New Mexico, Albuquerque (United States)

2013-12-15

This study explored a direct SET-photochemical strategy to construct a new family of thioene conjugated-naphthalamide fluorophore based lariat-crown ethers which show strong binding properties towards heavy metal ions. Irradiations of designed nitrogen branched (trimethylsilyl)methylthio-terminated polyethylenoxy-tethered naphthalimides in acidic methanol solutions have led to highly efficient photocyclization reactions to generate naphthalamide based lariat type thiadiazacrown ethers directly in chemo- and regio-selective manners which undergo very facile secondary dehydration reactions during separation processes to produce their corresponding amidoenethio ether cyclic products tethered with electron donating diethyleneoxy- and diethyenethio-side arm chains. Fluorescence and metal cation binding properties of the lariat type enamidothio products were examined. The photocyclized amidoenethio products, thioene conjugated naphthalamide fluorophore containing lariat-thiadiazacrowns exhibited strong fluorescence emissions in region of 330-450 nm along with intramolecular exciplex emissions in region of 450-560 nm with their maxima at 508 nm. Divalent cation Hg{sup 2+} and Pb{sup 2+} showed strong binding to sulfur atom(s) in side arm chain and atoms in enethiadiazacrown ether rings which led to significant enhancement of fluorescence from its chromophore singlet excited state and concomitant quenching of exciplex emission. The dual fluorescence emission responses towards divalent cations might provide a new guide for design and development of fluorescence sensors for detecting those metals.

Direct Interaction of CaVβ with Actin Up-regulates L-type Calcium Currents in HL-1 Cardiomyocytes*

Science.gov (United States)

Stölting, Gabriel; de Oliveira, Regina Campos; Guzman, Raul E.; Miranda-Laferte, Erick; Conrad, Rachel; Jordan, Nadine; Schmidt, Silke; Hendriks, Johnny; Gensch, Thomas; Hidalgo, Patricia

2015-01-01

Expression of the β-subunit (CaVβ) is required for normal function of cardiac L-type calcium channels, and its up-regulation is associated with heart failure. CaVβ binds to the α1 pore-forming subunit of L-type channels and augments calcium current density by facilitating channel opening and increasing the number of channels in the plasma membrane, by a poorly understood mechanism. Actin, a key component of the intracellular trafficking machinery, interacts with Src homology 3 domains in different proteins. Although CaVβ encompasses a highly conserved Src homology 3 domain, association with actin has not yet been explored. Here, using co-sedimentation assays and FRET experiments, we uncover a direct interaction between CaVβ and actin filaments. Consistently, single-molecule localization analysis reveals streaklike structures composed by CaVβ2 that distribute over several micrometers along actin filaments in HL-1 cardiomyocytes. Overexpression of CaVβ2-N3 in HL-1 cells induces an increase in L-type current without altering voltage-dependent activation, thus reflecting an increased number of channels in the plasma membrane. CaVβ mediated L-type up-regulation, and CaVβ-actin association is prevented by disruption of the actin cytoskeleton with cytochalasin D. Our study reveals for the first time an interacting partner of CaVβ that is directly involved in vesicular trafficking. We propose a model in which CaVβ promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane. PMID:25533460

75 FR 75932 - Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by...

Science.gov (United States)

2010-12-07

... Airworthiness Directives; Viking Air Limited (Type Certificate No. A-815 Formerly Held by Bombardier Inc. and de..., contact Viking Air Ltd., 9574 Hampden Road, Sidney, BC Canada V8L 5V5; telephone: (800) 663-8444; Internet... proposed AD. Discussion Viking Aircraft Limited has issued revisions to the DHC-3 Otter maintenance manual...

Refining types using type guards in TypeScript

NARCIS (Netherlands)

de Wolff, Ivo Gabe; Hage, J.

2017-01-01

We discuss two adaptations of the implementation of type guards and narrowing in the TypeScript compiler. The first is an improvement on the original syntax-directed implementation, and has now replaced the original one in the TypeScript compiler. It is specifically suited for the scenario in which

Semantics-Based Compiling: A Case Study in Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Danvy, Olivier; Vestergaard, René

1996-01-01

in the style of denotational semantics; – the output of the generated compiler is effectively three-address code, in the fashion and efficiency of the Dragon Book; – the generated compiler processes several hundred lines of source code per second. The source language considered in this case study is imperative......, block-structured, higher-order, call-by-value, allows subtyping, and obeys stack discipline. It is bigger than what is usually reported in the literature on semantics-based compiling and partial evaluation. Our compiling technique uses the first Futamura projection, i.e., we compile programs...... by specializing a definitional interpreter with respect to the program. Specialization is carried out using type-directed partial evaluation, which is a mild version of partial evaluation akin to lambda-calculus normalization. Our definitional interpreter follows the format of denotational semantics, with a clear...

75 FR 82329 - Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper...

Science.gov (United States)

2010-12-30

...-1295; Directorate Identifier 2010-CE-060-AD] RIN 2120-AA64 Airworthiness Directives; Piper Aircraft, Inc. (Type Certificate Previously Held by The New Piper Aircraft, Inc.) Models PA-46-310P, PA- 46-350P... applies to certain Piper Aircraft, Inc. Models PA-46-310P and PA-46-350P airplanes that are equipped with...

Effect of Direction Type, Emotional Valence of Words And Gender on Directed Forgetting

OpenAIRE

Sayar, Filiz

2018-01-01

In the present study, the effects of emotional valence of words and gender on directed forgettingwere investigated. The directed forgetting effect was investigated by requiring from participants toforget the words that they have to recall and at the same time, to recall the words that they have toforget. The study was composed of two experiments. In the first experiment, the participants werepresented with a list of words consisting of neutral and emotional words once, while the participantsw...

Mission Command During the War of Movement in World War I Initiative and Synchronization of the German Right Wing in August and Early September 1914

Science.gov (United States)

2014-12-04

höheren Truppenführer vom 24. Juni 1869,” in Moltkes Militärische Werke, Zweiter Theil, Die Tätigkeit als Chef des Generalstabs im Frieden, ed...the command structure with respect to the question of whether the individual instances reflect professional judgment given the information available...22.6.1866” in Moltkes Militärische Werke, Zweiter Theil, Die Tätigkeit als Chef des Generalstabs im Frieden, ed. Preußischer Generalstab (Berlin

Direct interaction of CaVβ with actin up-regulates L-type calcium currents in HL-1 cardiomyocytes.

Science.gov (United States)

Stölting, Gabriel; de Oliveira, Regina Campos; Guzman, Raul E; Miranda-Laferte, Erick; Conrad, Rachel; Jordan, Nadine; Schmidt, Silke; Hendriks, Johnny; Gensch, Thomas; Hidalgo, Patricia

2015-02-20

Expression of the β-subunit (CaVβ) is required for normal function of cardiac L-type calcium channels, and its up-regulation is associated with heart failure. CaVβ binds to the α1 pore-forming subunit of L-type channels and augments calcium current density by facilitating channel opening and increasing the number of channels in the plasma membrane, by a poorly understood mechanism. Actin, a key component of the intracellular trafficking machinery, interacts with Src homology 3 domains in different proteins. Although CaVβ encompasses a highly conserved Src homology 3 domain, association with actin has not yet been explored. Here, using co-sedimentation assays and FRET experiments, we uncover a direct interaction between CaVβ and actin filaments. Consistently, single-molecule localization analysis reveals streaklike structures composed by CaVβ2 that distribute over several micrometers along actin filaments in HL-1 cardiomyocytes. Overexpression of CaVβ2-N3 in HL-1 cells induces an increase in L-type current without altering voltage-dependent activation, thus reflecting an increased number of channels in the plasma membrane. CaVβ mediated L-type up-regulation, and CaVβ-actin association is prevented by disruption of the actin cytoskeleton with cytochalasin D. Our study reveals for the first time an interacting partner of CaVβ that is directly involved in vesicular trafficking. We propose a model in which CaVβ promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Direct band gap electroluminescence from bulk germanium at room temperature using an asymmetric fin type metal/germanium/metal structure

Energy Technology Data Exchange (ETDEWEB)

Wang, Dong, E-mail: wang.dong.539@m.kyushu-u.ac.jp; Maekura, Takayuki; Kamezawa, Sho [Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580 (Japan); Yamamoto, Keisuke; Nakashima, Hiroshi [Art, Science and Technology Center for Cooperative Research, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580 (Japan)

2015-02-16

We demonstrated direct band gap (DBG) electroluminescence (EL) at room temperature from n-type bulk germanium (Ge) using a fin type asymmetric lateral metal/Ge/metal structure with TiN/Ge and HfGe/Ge contacts, which was fabricated using a low temperature (<400 °C) process. Small electron and hole barrier heights were obtained for TiN/Ge and HfGe/Ge contacts, respectively. DBG EL spectrum peaked at 1.55 μm was clearly observed even at a small current density of 2.2 μA/μm. Superlinear increase in EL intensity was also observed with increasing current density, due to superlinear increase in population of elections in direct conduction band. The efficiency of hole injection was also clarified.

Clinical evaluation of digital angiographic system equipped with the Safire' flat-panel detector of a direct conversion type

Energy Technology Data Exchange (ETDEWEB)

Miura, Yoshiaki; Miura, Yusuke; Goto, Keiichi [Shimadzu Corporation, Medical Systems Division, Research and Development, Kyoto (JP)] [and others

2003-06-01

This report presents a report on clinical evaluation of our newly developed flat-panel X-ray detector of a direct conversion type, designed to provide images of a resolution higher than, or at least equal to, that ensured by X-ray photographic films, in clinical digital X-ray cinematography. This new detector was named 'Safire' the acronym of 'Shimadzu advanced flat imaging receptor', emphasizing its high technological level, such as the capability to ensure high quality of images. The clinical evaluation of Shimadzu DIGITEX Premier digital angiography system, equipped with this new flat-panel X-ray detector of a direct conversion type, has been started in March, 2003, at the Kokura Memorial Hospital in Kyushu, Japan. (author)

Certificering in het Hoger Onderwijs: De medewerking van professionals aan kwaliteitscontrole

Directory of Open Access Journals (Sweden)

Everard van Kemenade

2010-06-01

Dit artikel presenteert de resultaten van een onderzoek naar de bereidheid van professionals in Hogescholen in Nederland en Vlaanderen om mee te werken aan het accreditatieproces. Betoogd wordt dat accreditatie eigenlijk een vorm van certificering is. Conclusies zijn dat professionals loyaal zijn naar hun organisatie en bereid zijn verantwoording af te leggen. De nadruk in de certificering zou dan echter moeten liggen op de inhoud van het werk en de beoordeling zou moeten worden gedaan door vakgenoten (peer review. Er treden meer problemen op bij het certificeringproces, als het management de certificering onvoldoende ondersteunt of als de interne kwaliteitszorg onvoldoende op orde is. Er is een risico dat er window dressing optreedt. Uiteindelijk leidt dat tot de conclusie dat controle (door middel van bijvoorbeeld ISO of HKZcertificering gescheiden zou moeten worden van verbetering. Er zijn voldoende overeenkomsten tussen hoger onderwijs en maatschappelijk werk om te bezien of de resultaten ook gelden voor maatschappelijk werk.

Werking van ankerbouten in enkele soorten ondergrond : een simulatie-onderzoek naar verschillen in weerstand en sterkte en de inhoud daarvan op de werking van een barrier.

NARCIS (Netherlands)

Pol, W.H.M. van de

1997-01-01

Simulations were conducted to assess the performance of anchor bolts used in the steel Department of Public Works (RWS) barrier on various road surface types. The study was commissioned in response to doubts raised during the modelling of these bolts for a previous simulation carried out in 1995.

Pyrolysis of D-Glucose to Acrolein

Science.gov (United States)

Shen, Chong; Zhang, Igor Ying; Fu, Gang; Xu, Xin

2011-06-01

Despite of its great importance, the detailed molecular mechanism for carbohydrate pyrolysis remains poorly understood. We perform a density functional study with a newly developed XYG3 functional on the processes for D-glucose pyrolysis to acrolein. The most feasible reaction pathway starts from an isomerization from D-glucose to D-fructose, which then undergoes a cyclic Grob fragmentation, followed by a concerted electrocyclic dehydration to yield acrolein. This mechanism can account for the known experimental results.

Insight into a Pedagogical Sketchbook. Life and work of Eva Eyquem

OpenAIRE

Richter, Sabine

2016-01-01

Die vorliegende Arbeit dokumentiert und kontextualisiert das Werk der französischen Kunstpädagogin und ehemaligen Itten-Schülerin Eva Eyquem, geb. Plaut (1915-2009). Es ist meine Absicht, ihr Werk für Forschung und Lehre zugänglich zu machen und für einen kunstpädagogischen Diskurs zu öffnen, der sich mit Positionen in der Nachfolge der Bauhaus-Pädagogik befasst. Meine Arbeit ist in zwei Teile gegliedert. Sie umfasst eine Monografie zu Eva Eyquem, sowie eine fachwissenschaftliche Reflexion, i...

Casuïstiek van sociaal werkers, schatkamer of trompe-l'oeil?

Directory of Open Access Journals (Sweden)

Hilde Vlaeminck

2005-12-01

Full Text Available Casuïstiek is van oudsher een beproefd leermiddel in de geneeskunde en de moraalwetenschappen maar ook in het maatschappelijk werk. De oudste methodiek in het maatschappelijk werk – niet toevallig Social Casework genoemd – bestudeerde zorgvuldig praktijkgevallen, verteld door maatschappelijk werkers van het eerste uur (Kamphuis, 1971. Men trachtte toen de opgemerkte fenomenen en vastgestelde effecten te beschrijven, te verklaren en te verantwoorden met behulp van beschikbare wetenschappelijke kennis. Een eerste, opmerkelijke stap in een lang proces van professionalisering en kennisontwikkeling.

Remediation of the Lermontov mining site in Russia; Sanierung des Bergbaustandortes Lermontov in Russland

Energy Technology Data Exchange (ETDEWEB)

Krotkov, V.V. [Atomredmetzoloto, Moscow (Russian Federation)

2001-07-01

For 40 years, uranium mines were operated in the direct vicinity of the spas of Mineralnyje Wody, Pjatigorsk, Kislowodsk, Jessentuki and Shelesnowodsk by the Almaz company. Now that the mines have been abandoned, the spa region is surrounded by contaminated land. Remedial measures are projected in accordance with radiation protection standards. [German] 40 Jahre lang wurde Uranerzbergbau und -aufbereitung in unmittelbarer Naehe der Kurorte Mineralnyje Wody, Pjatigorsk, Kislowodsk, Jessentuki und Shelesnowodsk durch das Unternehmen Almaz betrieben. Gegenwaertig sind die Aktivitaeten des Unternehmens vollstaendig eingestellt. Als Folge entstanden im Gebiet der Kaukasischen Mineralbaeder uranhaltige Halden am Berg Beschtau mit einer Flaeche von 36,0 ha und am Berg Byk mit einer Flaeche von 18,4 ha. Im hydrometallurgischen Werk sind 44,5 ha Betriebsgelaende kontaminiert, wo sich Bauten fuer die Grund- und Hilfsproduktion, Erzlager, das werkseigene Chemielabor und das Heizkraftwerk befinden. Die IAA liegt 1,5 km vom Betriebsgelaende des hydrometallurgischen Werks entfernt und besteht aus fuenf Becken, wo von 1954 bis 1991 Rueckstaende der Uranproduktion eingelagert wurden. Seit 1991 gelangte dorthin Phosphorgips als Abprodukt der Verarbeitung von Apatit. Das sechste Becken ist fuer die Aufnahme von Wasser bei Stoerfaellen in den Hauptbecken bestimmt. Die IAA mit den angrenzenden Flaechen soll saniert werden. Vorrangig gilt es, geschaedigte Flaechen wiederherzustellen und die Situation im Bereich der IAA entsprechend den Normen des Strahlenschutzes sicher zu gestalten. Der Massnahmenkomplex fuer die Sanierung des Territoriums beinhaltet - Stillegung der abgearbeiteten Schlammbecken der IAA, - Rekultivierung der geschaedigten Flaechen im Bergbaugebiet, - Dekontamination der anliegenden kontaminierten Flaechen mit Background-{gamma}+20 {mu}R/h, - Schutz der Grundwaesser vor Kontamination durch eingelagerte Tailings des hydrometallurgischen Werks, - gesteurte Ableitung der

Development of a Direct Methanol Fuel Cell with Lightweight Disc Type Current Collectors

Directory of Open Access Journals (Sweden)

Yean-Der Kuan

2014-05-01

Full Text Available The direct methanol fuel cell (DMFC adopts methanol solution as a fuel suitable for low power portable applications. A miniature, lightweight, passive air-breathing design is therefore desired. This paper presents a novel planar disc-type DMFC with multiple cells containing a novel developed lightweight current collector at both the anode and cathode sides. The present lightweight current collector adopts FR4 Glass/Epoxy as the substrate with the current collecting areas located at the corresponding membrane electrolyte assembly (MEA areas. The current collecting areas are fabricated by sequentially coating a corrosion resistant layer and electrical conduction layer via the thermal evaporation technique. The anode current collector has carved flow channels for fuel transport and production. The cathode current collector has drilled holes for passive air breathing. In order to ensure feasibility in the present concept a 3-cell prototype DMFC module with lightweight disc type current collectors is designed and constructed. Experiments were conducted to measure the cell performance. The results show that the highest cell power output is 54.88 mW·cm−2 and successfully demonstrate the feasibility of this novel design.

Studies on the Effect of Radio Frequency Field in a Cusp-Type Charge Separation Device for Direct Energy Conversion

OpenAIRE

HAMABE, Masaki; IZAWA, Hiroaki; TAKENO, Hiromasa; NAKAMOTO, Satoshi; ICHIMURA, Kazuya; NAKASHIMA, Yousuke

2016-01-01

In D-3He fusion power generation, an application of direct energy conversion is expected in which separation of charged particles is necessary. A cusp-type direct energy converter (CuspDEC) was proposed as a charge separation device, but its performance was degraded for a high density plasma. The goal of the present study is to establish an additional method to assist charge separation by using a nonlinear effect of a radio frequency (rf) electric field. Following to the previous study, we ex...

The effects of involvement and ad type on attitudes toward direct-to-consumer advertising of prescription drugs.

Science.gov (United States)

Limbu, Yam; Torres, Ivonne M

2009-01-01

This article examines consumers' attitudes toward Direct-to-Consumer (DTC) advertising of prescription drugs that are influenced by the use different types of DTC ads and product involvement. Our findings suggest that product involvement and the type of DTC ad are significant predictors of consumers' attitudinal responses toward DTC advertising. High involvement consumers have more favorable attitudes toward the drug's price, DTC ad and brand name, and a higher intention to ask a doctor about the advertised drug than low involvement consumers. In contrast to Informational and Reminder DTC ads, Persuasive ads have more favorable effects on consumers' reactions to DTC prescription drug advertising.

Gesammelte Werke / Collected Works

Science.gov (United States)

Schwarzschild, Karl; Voigt, Hans-Heinrich

Der bekannte Astronom Karl Schwarzschild (1873-1916) gilt als der Begründer der Astrophysik und als hervorragender Forscher mit einer erstaunlichen Bandbreite seiner Interessen. Arbeiten zur Himmelsmechanik, Elektrodynamik und Relativitätstheorie weisen ihn als vorzüglichen Mathematiker und Physiker auf der Höhe seiner Zeit aus. Untersuchungen zur Photographischen Photometrie, Optik und Spektroskopie zeigen den versierten Beobachter, der sein Meßinstrumentarium beherrscht, und schließlich arbeitete Schwarzschild als Astrophysiker an Sternatmosphären, Kometen, Struktur und Dynamik von Sternsystemen. Die in seinem kurzen Leben entstandene Fülle an wissenschaftlichen Arbeiten ist in drei Bänden der Gesamtausgabe gesammelt, ergänzt durch biographisches Material, Annotationen von Fachleuten und einen Essay des Nobelpreisträgers S. Chandrasekhar. The well-known astronomer Karl Schwarzschild (1873-1916) is regarded as the founder of astrophysics and as an exceptionally talented researcher whose interests spanned a remarkably broad spectrum. His work on celestial mechanics, electrodynamics, and relativity theory demonstrates his great abilities as a mathematician and physicist who significantly influenced the science of his times. His investigations of photographic photometry, optics, and spectroscopy display his strengths as an observer who knew his instruments. But above all Schwarzschild pursued questions of astrophysics, addressing in particular stellar atmospheres, comets, and the structure and dynamics of stellar systems. The host of scientific works that he authored in his short life is now collected in the form of this three-volume complete works; it is supplemented by biographical material, notes from some of todays experts, and an essay by the Nobel Laureate S. Chandrasekhar.

Beter aan het werk

NARCIS (Netherlands)

Gerda Jehoel-Gijsbers

2007-01-01

Jarenlang was Nederland koploper in Europa in het aantal gevallen van ziekteverzuim en arbeidsongeschiktheid. Om dit probleem tegen te gaan zijn in de afgelopen decennia veel beleidsmaatregelen ontwikkeld en vaak ook weer aangepast. Hebben deze maatregelen tot resultaat geleid? Is het

Werking bodemherbiciden soms overschat

NARCIS (Netherlands)

Zeeland, van M.G.

2007-01-01

De werkingsduur van Goltix en isoproturon wordt in de praktijk overschat, zo blijkt uit onderzoek. De duurwerking kan worden verlengd door vaker te bespuiten in lage dosering. Een verslag over bodemherbiciden en bodemeigenschappen

Ein Nachkömmling Tristans : Warum hat Theodor Storm in seiner Novelle „Späte Rosen" Gottfried von Straßburgs „Tristan und Isolde" erwähnt?

OpenAIRE

田淵, 昌太

2010-01-01

Man hat bisher Theodor Storms Novelle „Späte Rosen" für ein Werk gehalten, das ein friedliches Familienleben beziehungweise das tägliche Zusammenleben eines Ehepaars schildert. Zum Beispiel hat Beate Charlotte Göhler in ihrer umfangreichen Storm-Biografie geschrieben, dass Theodor Storm mit diesem Werk seiner Frau Constanze eine Liebeserklärung machte („Ein Leben für die Graue Stadt" S.198). Wenn man diese Novelle nur oberflächlich liest, ist es eine mögliche Folge, dass man „Späte Rosen"...

Die anderen Ausdrucksweisen: subtile Offensiven Different Modes of Expression: Subtle Offensives

Directory of Open Access Journals (Sweden)

Ella Jasiowka

2002-03-01

Full Text Available Was passiert, wenn der „Herrscher des filmischen Blickes“ eine Frau ist? Anhand zweier jeweils sehr unterschiedlicher Beispiele „weiblicher“ Filmkunst zeigt die Autorin, dass es nötig ist, herkömmliche Interpretationsmuster zu überwinden, um dem Filmschaffen einzelner Künstler und Künstlerinnen auf den Grund zu gehen. Da es nicht die „feministische Kunst“ an sich gibt, muß man für das Werk so unterschiedlicher Künstlerinnen wie Sally Potter und Jane Campion jeweils unterschiedliche Schlüssel suchen, um ihnen gerecht zu werden. Dies tut Radkiewicz in ihrem Werk – aus feministischer Perspektive. Sie holt jeweils verschieden weit aus, wenn es darum geht, künstlerische Herkunft, Biographie, Vorbilder und Ziele der Künstlerinnen zu deren Werk in Bezug zu setzten. Ohne zu bahnbrechend neuen Erkenntnissen zu kommen, gelingt es ihr doch, ein komplexes Bild der von ihr behandelten Filmemacherinnen und den Filmen zu entwerfen, das einen umfassenden Gesamteindruck vermittelt. Die Kürze des Buches bringt dabei eine Konzentration mit sich, die zu einer Weiterbeschäftigung und Vertiefung einlädt.What happens if the filmmaker directing the audience’s gaze is a woman? Radkiewicz uses two very different examples of “female” film art to portray the two directions into which this kind of undertaking can lead. In so doing, she demonstrates that traditional methods of analysis no longer suffice to thoroughly examine the work of an artist. Since there is no neatly defined category of “feminist art,” one has to take into consideration different kinds of approaches in order to do justice to the work of film directors like Jane Campion and Sally Potter. Radkiewicz does exactly that in her work, and thus provides an analysis that is informed by a feminist perspective. She includes the filmmakers’ artistic trajectory, background, biography, and goals into her interpretation of Campion’s and Potter’s films. While Radkiewicz does

Selling Health to the Distracted: Consumer Responses to Source Credibility and Ad Appeal Type in a Direct-to-Consumer Advertisement.

Science.gov (United States)

Lemanski, Jennifer L; Villegas, Jorge

2015-01-01

Since 1997, when the U.S. Food and Drug Administration first allowed prescription drug companies to release ads directly targeting the public, direct-to-consumer (DTC) advertising has become an integral part of the pharmaceutical industry marketing toolkit, reaching over $4 billion in 2005. In an experiment where cognitive load, a task that requires the investment of a subject's memory in an unrelated task; source credibility; and advertising appeal type (affective or cognitive) were manipulated, attitude toward the ad was measured for a print DTC meningitis vaccine ad. Main effect results for source credibility and advertising appeal type on attitude toward the ad were found, and interactions between manipulated variables were apparent when the individual difference variables related to a specific illness (vaccination history, living in a dorm, family members or friends who had suffered the illness) were taken into account.

Targeting GPR30 in Abiraterone and MDV3100 Resistant Prostate Cancer

Science.gov (United States)

2017-12-01

chemotactic cytokines GROa, GROb, and GROg activate human neutrophil and basophil leukocytes. Journal of Biological Chemistry 268 15419–15424. Gregory AD...adenocarcinoma engineered to release IL-2, IL-4, IL-7, IL-10, IFN-a, IFN-g, and TNF-a. Laboratory Investigation 74 146–157. Nelson AW, Tilley WD, Neal...factor-1a (HIF-1a) in breast cancer cells and cardiomyocytes. Journal of Biological Chemistry 286 10773–10782. (doi:10.1074/jbc.M110.172247) Ryckman C

Nanofluid Types, Their Synthesis, Properties and Incorporation in Direct Solar Thermal Collectors: A Review.

Science.gov (United States)

Chamsa-Ard, Wisut; Brundavanam, Sridevi; Fung, Chun Che; Fawcett, Derek; Poinern, Gerrard

2017-05-31

The global demand for energy is increasing and the detrimental consequences of rising greenhouse gas emissions, global warming and environmental degradation present major challenges. Solar energy offers a clean and viable renewable energy source with the potential to alleviate the detrimental consequences normally associated with fossil fuel-based energy generation. However, there are two inherent problems associated with conventional solar thermal energy conversion systems. The first involves low thermal conductivity values of heat transfer fluids, and the second involves the poor optical properties of many absorbers and their coating. Hence, there is an imperative need to improve both thermal and optical properties of current solar conversion systems. Direct solar thermal absorption collectors incorporating a nanofluid offers the opportunity to achieve significant improvements in both optical and thermal performance. Since nanofluids offer much greater heat absorbing and heat transfer properties compared to traditional working fluids. The review summarizes current research in this innovative field. It discusses direct solar absorber collectors and methods for improving their performance. This is followed by a discussion of the various types of nanofluids available and the synthesis techniques used to manufacture them. In closing, a brief discussion of nanofluid property modelling is also presented.

Internationalization of Bachelor’s programmes in Social Work in Europe

Directory of Open Access Journals (Sweden)

Peter Hendriks

2016-03-01

Full Text Available Internationalization of Bachelor’s programmes in Social Work in EuropeThis article presents the results of a survey on the internationalization of Bachelor’s education in social work, which was carried out at 33 schools of social work across Europe. Many universities are seeking to “internationalize” their social work curriculum. However, although many social work educators are convinced of the importance of cross-border exchange, others are sceptical about the added value of internationalization for a professional career in social work. The aim of this study is to contribute to the discussion about the significance of internationalizing the curriculum of Bachelor’s programmes in social work. Since internationalization in itself is an ideological endeavour, educators must reflect on and formulate their own ideological motives and aspirations. To this end, representatives of schools of social work completed a questionnaire concerning the aim of internationalization, the structure of the curriculum, student and staff mobility, international policies and challenges. This study demonstrates that all universities have added an international dimension to their curricula. Many educators believe that internationalizing the social work curriculum contributes to qualitatively better future professionals “at home”. However, most of the respondents are dissatisfied with what has actually been achieved in terms of their universities’ international ambitions. This is due to a lack of language skills and facilities. Above all, we think, that this dissatisfaction is related to the underlying debate on universalism and indigenization in social work practice and education.  SAMENVATTINGDe internationalisering van de bachelors sociaal werk in EuropaIn dit artikel worden de uitkomsten gepresenteerd van een survey naar internationalisering van het sociaal werk bachelor onderwijs, uitgevoerd onder 33 opleidingen sociaal werk, verspreid over Europa

Type Inference for Session Types in the Pi-Calculus

DEFF Research Database (Denmark)

Graversen, Eva Fajstrup; Harbo, Jacob Buchreitz; Huttel, Hans

2014-01-01

In this paper we present a direct algorithm for session type inference for the π-calculus. Type inference for session types has previously been achieved by either imposing limitations and restriction on the π-calculus, or by reducing the type inference problem to that for linear types. Our approach...

Automation of the solution type of intensity modulated radiation therapy with direct planning neoplastic breast lesions

International Nuclear Information System (INIS)

Fuente Rosales, Liset De La; Larrinaga Cortina, Eduardo Francisco

2009-01-01

Breast cancer ranks first among the lesions malignancies involving the Cuban women and the second in mortality only surpassed by lung injury. The breast-conserving surgery is becoming less appeal, with an increase in the choice of radiotherapy to the breast operated, and the surgical bed. Intensity Modulated Radiation Therapy, IMRT has demonstrated better results in the dose distribution for irradiation dimensional treatment breast shaping, 3DCRT. We developed a MATLAB application to obtain the solution type to direct planning IMRT for breast neoplasm. The technique was implemented in the Planning System Treatment Plus Theraplan v3.8 and Precise1 ELEKTA linear accelerator. Static segments are constructed for each portal of incidence and Excel files are exported as the positions of the blades. The technique was validated with a patient, which he performed a radiographic study of computerized axial tomography planning purposes. The standard solution built is consistent with those reported internationally and consists of a segment type and at least two segments of type B. The assignment of the relative weights of the segments is done manually by trial and error procedure, with the general rule of 90% by weight assigned to segment A and the remaining 10% divided equally between B-type segments IMRT breast obtained in a dose 17% homogeneity better than 3DCRT and reduced the average dose in the lung ipsilateral 15%. (author)

The Contribution of F.W. Taylor to Industrial and Organizational Psychology

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E. C. Thomas

1982-11-01

In die artikel word getoon dat F.W. Taylor die erkende "vader van wetenskaplike bestuur" ook erkenning behoort te geniet as grondlegger van die Bedryf en -organisasiesielkunde. Sy werk op die terreine van prestasiemotivering en tevredenheid, opleiding, plasing van werkers, bestuurs- en organisasieontwikkeling en arbeidsverhoudinge het waarskynlik die werk van erkende sielkundiges op hierdie gebiede vooruitgeloop, of grondslag daarvoor gelê. Daar word tot die slotsom gekom dat alhoewel Taylor nie 'n opgeleide sielkundige was nie, hy en sy kollegas erkenning moet kry vir die praktiese implimentering van die beginsels en teorieë van die moderne Bedryf- en Organisasiesielkunde.

DIRECTIVE SPEECH ACTS REALIZATION OF INDONESIAN EFL TEACHER

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Cucu Suhartini

2015-06-01

Full Text Available This research examines the types and functions of directive speech act performed by an Indonesian EFL teacher in one senior high school in Kuningan, Indonesia. This study uses qualitative method. The data of this research were taken from the video transcription which contains directives spoken by the EFL teacher and analyzed based on Kreidler’s (1998 theory. The findings show that there are three types of directives used by the teacher. They are commands, requests, and suggestions. The most frequent type of directives performed is commands with 233 occurrences (94.8%. It was also found that there are five functions seized by the directives, they are elicitation, instruction, advice, threat, and attention-getter. The most frequent function of directives used is elicitation with 108 occurrences (44%. From the findings, it is concluded that the using of commands shows teacher’s dominance. Yet, this type of directives is not easily understood by the students. Therefore, it is suggested that the teacher should use other types of directives more, such as requests and suggestions, to encourage students’ participation.

Directional response of identifier Micro Detective ORTEC, N-type with 15% of detection efficiency

International Nuclear Information System (INIS)

Arbach, Mayara Nascimento; Karam, Rudnei M.; Cardoso, Domingos D.O.; Sant'anna, Viviane C.; Vellozo, Sergio de O.; Gomes, Renato G.; Amorim, Aneuri S. de; Oliveira, Luciano S.R.

2016-01-01

It was characterized the directional response of identifier Micro Detective ORTEC, N-type with 15% of detection efficiency by using sources of Cesium ("1"3"7Cs) with activity of 37,4 kBq and Cobalt ("6"0Co) with an activity of 41 kBq, manufactured on 04/17/2007. The work took place in distances (0,5m, 1,0m, 1,5m e 2,0m) and for the angles (0°, 45°, 60° e 90°), and the measure found in angle 0° of said evaluation was adopted as reference value; this same procedure was adopted for other distances evaluated in this work. The results achieved are provided in charts 1, 2 and 3. (author)

Direct Evidence of Mg Incorporation Pathway in Vapor-Liquid-Solid Grown p-type Nonpolar GaN Nanowires

OpenAIRE

Patsha, Avinash; Amirthapandian, S.; Pandian, Ramanathaswamy; Bera, S.; Bhattacharya, Anirban; Dhara, Sandip

2015-01-01

Doping of III-nitride based compound semiconductor nanowires is still a challenging issue to have a control over the dopant distribution in precise locations of the nanowire optoelectronic devices. Knowledge of the dopant incorporation and its pathways in nanowires for such devices is limited by the growth methods. We report the direct evidence of incorporation pathway for Mg dopants in p-type nonpolar GaN nanowires grown via vapour-liquid-solid (VLS) method in a chemical vapour deposition te...

Five-colour photometry of early-type stars in the direction of galactic X-ray sources

International Nuclear Information System (INIS)

Van Paradijs, J.; Van Amerongen, S.; Damen, E.; Van der Woerd, H.

1986-01-01

We present the results of five-colour photometry of 551 O- and B-type stars located in 17 fields of a few square degrees around galactic X-ray sources. From a comparison of reddening-free combinations of colour indices with theoretical values, calculated for model atmospheres of Kurucz, we derive effective temperature and surface gravity for these stars. In addition we find their absolute magnitude by combining these parameters with the results of evolutionary calculations of massive stars. These effective temperatures are in good agreement with the temperature scale of Bohm-Vitense for stars of luminosity classes II to V. For the supergiants the effective temperatures are about 40% higher. For stars of luminosity classes III to V the absolute magnitudes we find agree well with the results of independent luminosity calibrations of spectral types, but for brighter stars they deviate systematically. We suspect that the origin of these deviations lies in the failure of present low-gravity model atmospheres to represent supergiant atmospheres. We have used the photometric data to study the interstellar reddening in the direction of the X-ray sources

Quantifying the weight of fingerprint evidence through the spatial relationship, directions and types of minutiae observed on fingermarks.

Science.gov (United States)

Neumann, Cedric; Champod, Christophe; Yoo, Mina; Genessay, Thibault; Langenburg, Glenn

2015-03-01

This paper presents a statistical model for the quantification of the weight of fingerprint evidence. Contrarily to previous models (generative and score-based models), our model proposes to estimate the probability distributions of spatial relationships, directions and types of minutiae observed on fingerprints for any given fingermark. Our model is relying on an AFIS algorithm provided by 3M Cogent and on a dataset of more than 4,000,000 fingerprints to represent a sample from a relevant population of potential sources. The performance of our model was tested using several hundreds of minutiae configurations observed on a set of 565 fingermarks. In particular, the effects of various sub-populations of fingers (i.e., finger number, finger general pattern) on the expected evidential value of our test configurations were investigated. The performance of our model indicates that the spatial relationship between minutiae carries more evidential weight than their type or direction. Our results also indicate that the AFIS component of our model directly enables us to assign weight to fingerprint evidence without the need for the additional layer of complex statistical modeling involved by the estimation of the probability distributions of fingerprint features. In fact, it seems that the AFIS component is more sensitive to the sub-population effects than the other components of the model. Overall, the data generated during this research project contributes to support the idea that fingerprint evidence is a valuable forensic tool for the identification of individuals. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Nanofluid Types, Their Synthesis, Properties and Incorporation in Direct Solar Thermal Collectors: A Review

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Wisut Chamsa-ard

2017-05-01

Full Text Available The global demand for energy is increasing and the detrimental consequences of rising greenhouse gas emissions, global warming and environmental degradation present major challenges. Solar energy offers a clean and viable renewable energy source with the potential to alleviate the detrimental consequences normally associated with fossil fuel-based energy generation. However, there are two inherent problems associated with conventional solar thermal energy conversion systems. The first involves low thermal conductivity values of heat transfer fluids, and the second involves the poor optical properties of many absorbers and their coating. Hence, there is an imperative need to improve both thermal and optical properties of current solar conversion systems. Direct solar thermal absorption collectors incorporating a nanofluid offers the opportunity to achieve significant improvements in both optical and thermal performance. Since nanofluids offer much greater heat absorbing and heat transfer properties compared to traditional working fluids. The review summarizes current research in this innovative field. It discusses direct solar absorber collectors and methods for improving their performance. This is followed by a discussion of the various types of nanofluids available and the synthesis techniques used to manufacture them. In closing, a brief discussion of nanofluid property modelling is also presented.

Molecular typing for blood group antigens within 40 minutes by direct PCR from plasma or serum

Science.gov (United States)

Wagner, Franz Friedrich; Flegel, Willy Albert; Bittner, Rita; Döscher, Andrea

2016-01-01

Determining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid-cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fya, Fyb, Jka and Jkb antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false-negative rate. With fast turnaround times, the rapid-cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting. PMID:27991657

Analysis of the Torque Ripples in Designing a Disk Type Brushless Direct Current Motor

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A. V. Stepanov

2015-01-01

Full Text Available This paper investigates the torque ripples of disk-type low-power brushless direct current motor (BDCM with permanent magnets. In spite of numerous studies on designing of valve engines this issue is understudied as yet. The torque ripples cause noise and vibration and can significantly limit accuracy when used in instrumentation, computer technology.We consider a motor that includes a power unit consisting of a rotor and a stator. There are ferrite elements of sensor on the rotor, and the nonmagnetic disk, bonded to it, contains permanent magnets. The rotor is mounted on a rotating shaft. The stator consists of a steel casing and bonded to it non-magnetic, non-conductive disk with holes. In the disk holes from both sides are mounted armature coils. The armature winding consists of two sections each of which has 6 coils. Each adjacent coil in section has an opposite direction of winding. The coils are arranged circumferentially and are shifted relative to each other; the displacement angle between the coils of one section is equal to 2π/6 (rad. Sections are also shifted relative to each other; the angular shift is π/6 (rad. Sections are connected to the output terminals of the electronic switch. Sections of motor windings have the reverse full-wave power.The paper has investigated the steady operation at four-stroke switching and under constant load (torque. In this case, the electromagnetic torque and rotor speed are periodical functions of the rotor rotation angle. The dependencies of the averaged torque on the rotation speed have been obtained. The spectral distribution of the torque ripples at various rotor speeds of rotation has been calculated. The dependencies of the torque on the speed were studied both at constant speed and taking into account the uneven speed. Based on the research findings of disk type BDCM was computed a level of ripples amounted to 0.8 - 5%, which is quite acceptable for use in a drive. The results are useful for

The direct l-type resonance spectrum of CF3CCH in the vibrational state ν 10 = 2

International Nuclear Information System (INIS)

Woetzel, Ulf; Maeder, Heinrich; Harder, Hauke; Pracna, Petr; Sarka, Kamil

2005-01-01

The direct l-type resonance spectrum of CF 3 CCH in the vibrational state ν 10 = 2 has been measured by means of waveguide microwave Fourier transform spectroscopy in the range 8-26 GHz. Two types of direct l-type resonance transitions induced by the (Δk = ±2, Δl = ±2) interaction could be observed: 262 transitions following the ΔJ = 0, Δk = Δl = 2 selection rule covering values of J = 17-64 and G vertical bar k - l vertical bar from 2 to 15, and 75 transitions following the ΔJ = 0, Δk = Δl = 4 selection rule covering values of J = 44-70 and G up to 3. The strong (2, 2) resonance furthermore allowed the observation of A 1 -A 2 splittings of the k = l = ±2 states from J = 63-70. The transitions with G = 3 showed splittings due to the (4, -2) and (0, 6) interactions. The corresponding energy level systems and part of the Hamiltonian matrix are discussed. Strong perturbations due to Δ(k - l) = 3 interactions coupling the states k = ±1, l = ±2 and k = ±4, l ±2 made possible the observation of perturbation-allowed transitions with selection rule k = ±1, l =± 2 ↔ k = 0, l = ±2. Additionally, the J = 2-1 and 3-2 rotational transitions have been measured. A multiple fitting analysis has been performed in which the experimental data have been fitted using five reduced forms of the effective Hamiltonian as proposed by Sarka and Harder [J. Mol. Spectrosc. 197 (1999) 254]. Parameters up to sixth order have been determined including the axial rotational constant A for both values of vertical bar l vertical bar and the unitary equivalence of the determined parameter sets has been demonstrated

Determination of type, magnitude and direction of residual stresses generated in the welding of AISI H-13 steel with the hole drilling method

International Nuclear Information System (INIS)

Mejia; I; Maldonado, C; Bedolla, A; Velez, M; Medina, A; Bejar, L

2006-01-01

AISI H-13 steel is considered to be a highly ultra resistant steel because its resistance to stress surpasses 1380 MPa. This steel is widely used in tools that heavily used, especially under high temperatures, such as: awls, molds for pressing, extrusion dies, extrusion tools from heat impact, tools for producing screws, bolts, rivets and taps, molds for centrifugal smelting, tools for presses with shaped pieces, knives for hot cutting, among others. The weldability of AISI H-13 steel is generally poor, but it is possible if the proper precautions are taken. Cracking is perhaps the factor that most limits the weldability of AISI H-13 steel. The tendency to crack during welding for this type of steel occurs in the base metal and the zone close to the supporting material (cold cracking). The interlayer covering technique is used in the repair, welding and recovery of pieces of high alloy steels in order to avoid cracking and to lower the residual stresses generated by obstructed contraction and martensitic transformation. This work defined the type, magnitude and direction of residual stresses at different distances starting from the center of the welded union on the 25.4 mm thick AISI H-13 steel sheet. The welding was carried out in a test piece with Y-Groove geometry following JIS Z 3158 standard, using the SMAW process and an AISI 312 stainless steel interlayer between the base metal and the supporting metal. The hole-drilling method was used to measure the type, magnitude and direction of residual stresses using extensometric gauge rosette CEA-06-062UM-120 and CEA-06-062RE-120 following the guidelines established by ASTM E 837 standard. Based on the relaxed deformations that were measured, the type, magnitude and direction of residual stresses were determined with the H-DRILL residual stress program for biaxial condition. The results indicate that under these welding conditions the residual strains at different distances from the welded union are from stress and

Stimmen des Leis, schillernde Gewebe / Christoph Schlüren

Index Scriptorium Estoniae

Schlüren, Christoph

1995-01-01

Baltische Werke für Streichorchester: Vol. 1: Balakauskas: Ostrobothnian Symphony, Vasks: Symphonie "Stimmen", Narbutaite: Opus Lugubre; Vol. 2: Kutavicius: Nothern Gates, Vasks: Cantabile, Tüür: Insula Deserta, Rekasius: Music for strings, Werke von Urbaitis und Juozapaitis; Ostrobothnian Chamber Orchestra, Dirigent: Juha Kangas; Finlandia / east-west CD-s 4509-97892-2 und 4509-97893-2. Vasks: Cantabile, Englischhorn-Konzert, Botschaft, Musica dolorosa, Lauda; Riga Philarmonic Orchestra, Dirigent: Kriss Rusmanis; Confer / BMG 75605-51236-2. Eller: Morgenrot, Abendrot, 5 Stücke für Streicher, Geister, Im Schatten und im Sonnenlicht, Elegia; Estonian Symphony Orchestra, Dirigent: Peeter Lilje; Forte FD 0020/2. Tubin: 11. Symphonie, Elegie für Streicher, Raid: 2. Symphonie; Estnisches Staatliches Symphonieorchester, Dirigent: Arvo Volmer; Koch 3-7291-2 H1. Sumera: Symphonien 1-3; Malmö Symphony Orchestra, Dirigent: Paavo Järvi; BIS/Disco-Center 660. Sumera: Klavierkonzert, 4. Symphonie, Musica tenera; Malmö Symphony Orchestra, Dirigent: Paavo Järvi; BIS/Disco-Center 690. Tormis: Werke für Männerchor; Estnischer Nationaler Männerchor, Dirigent: Olev Oja; Forte CDs FD 0011/2 und FD 0019/2 Tutvustatakse uusi heliplaate Baltimaade heliloojate loomingust.

‘Op de wijze van Kavafis’: Die voorbeeld van die digter uit Alexandrië

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Phil van Schalkwyk

2014-12-01

Full Text Available Die Griekse digter K.P. Kavafis (1863–1933 word wêreldwyd deur lesers sowel as skrywers besonder hoog geag. Hy het nie net van die grootste twintigste-eeuse skrywers beïnvloed nie,maar is vanweë die buitengewone vertaalbaarheid van sy werk ook betreklik sterk teenwoordig in die letterkunde van meer tale as slegs Grieks en Engels. Vir baie – veral gay lesers, skrywers en kunstenaars – besit Kavafis ’n voorbeeldstatus, ten opsigte van die letterkunde sowel asdie lewe. W.H. Auden het beweer dat dit wat Kavafis onderskei, sy stemtoon is, een wat ’n persoon met ’n unieke perspektief op die wêreld openbaar. Hierdie bydrae, wat deel is van ’nnavorsingsprojek oor idiolektiese skrywersidentiteit, is daarop gerig om die onderskeidende kenmerke van Kavafis se werk, sowel in terme van vorm as inhoud, opnuut te ondersoek. Dit word gedoen binne die raamwerk van die breë kritiese diskoers oor Kavafis en met verwysing na enkele manifestasies/voorbeelde van Nederlandse en Afrikaanse kritiese en kreatieweperspektiewe op sy poësie, met die doel om spesifiek lig te werp op die besondere soortwysheid wat in Kavafis se werk oorgedra word.

Ingeborg Drewitz im literarischen und politischen Feld Ingeborg Drewitz in the Field of Literature and Politics

Directory of Open Access Journals (Sweden)

Regina Schleicher

2007-03-01

Full Text Available Der aus einer Berliner Tagung im November 2003 hervorgegangene Band „Von der Unzerstörbarkeit des Menschen“ versammelt zahlreiche interessante Beiträge zu Leben und Werk der Autorin Ingeborg Drewitz. Der erste Teil des Bandes ist unter dem Titel „Vita activa“ vor allem dem vielfältigen politischen Engagement der Autorin gewidmet, während „Themen und Schreibweisen“ ihres literarischen Werks in einem sehr umfangreichen zweiten Teil behandelt werden. Insgesamt zeichnen die Texte in dem Band ein sehr differenziertes Bild von Ingeborg Drewitz als engagierter Schriftstellerin und von ihrem Werk.The volume “On Human Indestructibility” (“Von der Unzerstörbarkeit des Menschen“, which is based on a conference held in Berlin in November 2003, contains numerous interesting contributions on the life and work of the author Ingeborg Drewitz. The first part of the volume, which is entitled “Vita activa,” is dedicated to the author’s numerous political engagements, while the expansive second section, “Themes and Syntax,” approaches her literary work. In total, the texts in the volume draw a differentiated image of the politically engaged author Ingeborg Drewitz and of her work.

Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology.

Directory of Open Access Journals (Sweden)

Thomas Rotolo

Full Text Available In mammals, genetically-directed cell labeling technologies have not yet been applied to the morphologic analysis of neurons with very large and complex arbors, an application that requires extremely sparse labeling and that is only rendered practical by limiting the labeled population to one or a few predetermined neuronal subtypes.In the present study we have addressed this application by using CreER technology to non-invasively label very small numbers of neurons so that their morphologies can be fully visualized. Four lines of IRES-CreER knock-in mice were constructed to permit labeling selectively in cholinergic or catecholaminergic neurons [choline acetyltransferase (ChAT-IRES-CreER or tyrosine hydroxylase (TH-IRES-CreER], predominantly in projection neurons [neurofilament light chain (NFL-IRES-CreER], or broadly in neurons and some glia [vesicle-associated membrane protein2 (VAMP2-IRES-CreER]. When crossed to the Z/AP reporter and exposed to 4-hydroxytamoxifen in the early postnatal period, the number of neurons expressing the human placental alkaline phosphatase reporter can be reproducibly lowered to fewer than 50 per brain. Sparse Cre-mediated recombination in ChAT-IRES-CreER;Z/AP mice shows the full axonal and dendritic arbors of individual forebrain cholinergic neurons, the first time that the complete morphologies of these very large neurons have been revealed in any species.Sparse genetically-directed, cell type-specific neuronal labeling with IRES-creER lines should prove useful for studying a wide variety of questions in neuronal development and disease.

Direct-Current Forced Interruption and Breaking Performance of Spiral-Type Contacts in Aero Applications

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Wenlei Huo

2017-05-01

Full Text Available This paper analyses the transient characteristics and breaking performance of direct-current (DC forced-interruption vacuum interrupters in 270 V power-supply systems. Three stages are identified in forced interruption: the DC-arcing stage, current-commutation stage, and voltage-recovery stage. During the current-commutation stage, the reverse peak-current coefficient k, which is a key design factor, is used to calculate the rate of current at zero-crossing (di/dt. MATLAB/Simulink simulation models are established to obtain the transient characteristics influenced by the forced-commutation branch parameters and the coefficient k. To study the breaking performance of spiral-type contacts, experiments are conducted for different contact materials and arcing times for currents less than 3.5 kA. During the DC-arcing stage, a locally intensive burning arc is observed in the CuW80 contact; however, it is not observed in the CuCr50 contact. On examining the re-ignition interruption results of the CuW80 contact, the intensive burning arc is found to be positioned within a possible re-ignition region. When the arcing time is longer than 1 ms, the intensive burning arc occurs and affects the breaking performance of the spiral-type contacts. If the DC-arcing stage is prolonged, the total arcing energy increases, which leads to a lower breaking capacity.

Thoracic type Ia endoleak: direct percutaneous coil embolization of the aortic arch at the blood entry site after TEVAR and double-chimney stent-grafts

Energy Technology Data Exchange (ETDEWEB)

Bangard, Christopher; Franke, Mareike; Maintz, David; Chang, De-Hua [University Hospital, University of Cologne, Department of Radiology, Cologne (Germany); Pfister, Roman [University Hospital, University of Cologne, Department of Internal Medicine III, Cologne (Germany); Deppe, Antje-Christin [University Hospital, University of Cologne, Department of Cardiothoracic Surgery, Cologne (Germany); Matoussevitch, Vladimir [University Hospital, University of Cologne, Department of Vascular Surgery, Cologne (Germany)

2014-06-15

To introduce a novel percutaneous technique to stop blood entry at the lesser aortic arch curvature by coil embolisation in type Ia endoleak after TEVAR. A 61-year-old Marfan patient presented with type Ia endoleak of the aortic arch and a growing aortic arch pseudoaneurysm after TEVAR. Multiple preceding operations and interventions made an endovascular approach unsuccessful. Direct percutaneous puncture of the aneurysmal sac would have cured the sign, but not the cause of blood entry at the lesser curvature of the aortic arch. Direct CT-guided percutaneous puncture of the blood entry site in the aortic arch with fluoroscopically guided coil embolisation using detachable extra-long coils was successfully performed. Three weeks after the intervention, the patient developed fever because of superinfection of the pseudoaneurysm. The blood cultures and CT-guided mediastinal aspirate were sterile. After intravenous administration of antibiotics, the fever disappeared and the patient recovered. Six-month follow-up showed permanent closure of the endoleak and a shrinking aneurysmal sac. Direct percutaneous puncture of the aortic arch at the blood entry site of a thoracic type Ia endoleak after TEVAR and double-chimney stent-grafts with coil embolisation of the wedge-shaped space between the lesser aortic curvature and the stent-graft is possible. (orig.)

Thoracic type Ia endoleak: direct percutaneous coil embolization of the aortic arch at the blood entry site after TEVAR and double-chimney stent-grafts

International Nuclear Information System (INIS)

Bangard, Christopher; Franke, Mareike; Maintz, David; Chang, De-Hua; Pfister, Roman; Deppe, Antje-Christin; Matoussevitch, Vladimir

2014-01-01

To introduce a novel percutaneous technique to stop blood entry at the lesser aortic arch curvature by coil embolisation in type Ia endoleak after TEVAR. A 61-year-old Marfan patient presented with type Ia endoleak of the aortic arch and a growing aortic arch pseudoaneurysm after TEVAR. Multiple preceding operations and interventions made an endovascular approach unsuccessful. Direct percutaneous puncture of the aneurysmal sac would have cured the sign, but not the cause of blood entry at the lesser curvature of the aortic arch. Direct CT-guided percutaneous puncture of the blood entry site in the aortic arch with fluoroscopically guided coil embolisation using detachable extra-long coils was successfully performed. Three weeks after the intervention, the patient developed fever because of superinfection of the pseudoaneurysm. The blood cultures and CT-guided mediastinal aspirate were sterile. After intravenous administration of antibiotics, the fever disappeared and the patient recovered. Six-month follow-up showed permanent closure of the endoleak and a shrinking aneurysmal sac. Direct percutaneous puncture of the aortic arch at the blood entry site of a thoracic type Ia endoleak after TEVAR and double-chimney stent-grafts with coil embolisation of the wedge-shaped space between the lesser aortic curvature and the stent-graft is possible. (orig.)

THE DIRECTIVE SPEECH ACTS USED IN ENGLISH SPEAKING CLASS

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Muhammad Khatib Bayanuddin

2016-12-01

Full Text Available This research discusses about an analysis of the directive speech acts used in english speaking class at the third semester of english speaking class of english study program of IAIN STS Jambi. The aims of this research are to describe the types of directive speech acts and politeness strategies that found in English speaking class. This research used descriptive qualitative method. This method used to describe clearly about the types and politeness strategies of directive speech acts based on the data in English speaking class. The result showed that in English speaking class that there are some types and politeness strategies of directive speech acts, such as: requestives, questions, requirements, prohibitives, permissives, and advisores as types, as well as on-record indirect strategies (prediction statement, strong obligation statement, possibility statement, weaker obligation statement, volitional statement, direct strategies (imperative, performative, and nonsentential strategies as politeness strategies. The achievement of this research are hoped can be additional knowledge about linguistics study, especially in directive speech acts and can be developed for future researches. Key words: directive speech acts, types, politeness strategies.

Direct transformation of xylan-type hemicelluloses to furfural via SnCl₄ catalysts in aqueous and biphasic systems.

Science.gov (United States)

Wang, Wenju; Ren, Junli; Li, Huiling; Deng, Aojie; Sun, Runcang

2015-05-01

Direct catalytic transformation of xylan-type hemicelluloses to furfural in the aqueous system and the biphasic system were comparatively investigated under mild conditions. Screening of several promising chlorides for conversion of beech xylan in the aqueous system revealed the Lewis acid SnCl4 was the most effective catalyst. Comparing to the single aqueous system, the bio-based 2-methyltetrahydrofuran (2-MTHF)/H2O biphasic system was more conducive to the synthesis of furfural, in which the highest furfural yield of 78.1% was achieved by using SnCl4 as catalysts under the optimized reaction conditions (150°C, 120 min). Additionally, the influences of xylan-type hemicelluloses with different chemical and structural features from beech, corncob and bagasse on the furfural production were studied. It was found that furfural yield to some extent was determined by the xylose content in hemicelluloses and also had relationships with the molecular weight of hemicelluloses and the degree of crystallization. Copyright © 2015 Elsevier Ltd. All rights reserved.

Weather Types, temperature and relief relationship in the Iberian Peninsula: A regional adiabatic processes under directional weather types

Science.gov (United States)

Peña Angulo, Dhais; Trigo, Ricardo; Cortesi, Nicola; Gonzalez-Hidalgo, Jose Carlos

2016-04-01

We have analyzed at monthly scale the spatial distribution of Pearson correlation between monthly mean of maximum (Tmax) and minimum (Tmin) temperatures with weather types (WTs) in the Iberian Peninsula (IP), represent them in a high spatial resolution grid (10km x 10km) from MOTEDAS dataset (Gonzalez-Hidalgo et al., 2015a). The WT classification was that developed by Jenkinson and Collison, adapted to the Iberian Peninsula by Trigo and DaCamara, using Sea Level Pressure data from NCAR/NCEP Reanalysis dataset (period 1951-2010). The spatial distribution of Pearson correlations shows a clear zonal gradient in Tmax under the zonal advection produced in westerly (W) and easterly (E) flows, with negative correlation in the coastland where the air mass come from but positive correlation to the inland areas. The same is true under North-West (NW), North-East (NE), South-West (SW) and South-East (SE) WTs. These spatial gradients are coherent with the spatial distribution of the main mountain chain and offer an example of regional adiabatic phenomena that affect the entire IP (Peña-Angulo et al., 2015b). These spatial gradients have not been observed in Tmin. We suggest that Tmin values are less sensitive to changes in Sea Level Pressure and more related to local factors. These directional WT present a monthly frequency over 10 days and could be a valuable tool for downscaling processes. González-Hidalgo J.C., Peña-Angulo D., Brunetti M., Cortesi, C. (2015a): MOTEDAS: a new monthly temperature database for mainland Spain and the trend in temperature (1951-2010). International Journal of Climatology 31, 715-731. DOI: 10.1002/joc.4298 Peña-Angulo, D., Trigo, R., Cortesi, C., González-Hidalgo, J.C. (2015b): The influence of weather types on the monthly average maximum and minimum temperatures in the Iberian Peninsula. Submitted to Hydrology and Earth System Sciences.

Konstruktivisme, konstruksionisme en maatskaplike werk

Directory of Open Access Journals (Sweden)

M.J.M. du Plessis

2000-03-01

Full Text Available Constructivism, constructionism and social workIn this article the constructivistic framework of reasoning is illustrated with reference to the premises of the structure determinism of Maturana, Kelly's personality constructs theory, and the radical constructivism as developed by Von Glasersfeld. Proceeding to the constructivistic frame of thought that reality is created by each individual with reference to particular internal processes (specifically cognitive processes, constructionism indicates, according to the social construct theory, that the interaction between individuals is responsible for the process of reality creation. The core of the frameworks of reasoning involves that reality is not created by the individual or individuals, and that, therefore not only one objective reality exists, but in fact a range of subjective realities - realities that are continually adapted by means of a process of evolution. As the individual is exposed to new experiences, he attaches new unique meanings to it, and this continually creates another reality. This view implies specific implications for the profession of Social Work. For example, final and objective diagnoses about persons, families, groups or communities cannot be made, as such diagnoses are based on a subjective reality created by a social worker in a certain situation. Indeed, there is no objective reality against which those concerned could be measured in order to come to a conclusion. Further, constructivism and constructionism imply that the social worker departs from a position of "not-knowing". He is therefore not the only skilled person, but seeks, together with the client, new realities that could contain the solution of the problems of the client.

Global Ear. Werke 2001 - 2006

Index Scriptorium Estoniae

2006-01-01

Dresdenis muusikafestivalil "Global Ear" 23.3.03 esitusel Eesti heliloojate muusika: Helena Tulve "lumineux/opaque", Jaan Rääts "Meditation", Mirjam Tally "Aura", Mati Kuulberg "Sonate Nr.4", Mari Vihmand "Seitsmele"

Type I Interferons Direct Gammaherpesvirus Host Colonization.

Directory of Open Access Journals (Sweden)

Cindy S E Tan

2016-05-01

Full Text Available Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4 infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization.

Impedance matching of pillbox-type RF windows and direct measurement of the ceramic relative dielectric constant

Energy Technology Data Exchange (ETDEWEB)

Ao, Hiroyuki, E-mail: hiroyuki.ao@j-parc.jp [Japan Atomic Energy Agency (JAEA), J-PARC Center, Accelerator Division, 2-4, Shirakara Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan); Asano, Hiroyuki [Japan Atomic Energy Agency (JAEA), J-PARC Center, Accelerator Division, 2-4, Shirakara Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan); Naito, Fujio [High Energy Accelerator Research Organization (KEK), 1-1, Oho, Tsukuba, Ibaraki 305-0801 (Japan); Ouchi, Nobuo; Tamura, Jun [Japan Atomic Energy Agency (JAEA), J-PARC Center, Accelerator Division, 2-4, Shirakara Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan); Takata, Koji [High Energy Accelerator Research Organization (KEK), 1-1, Oho, Tsukuba, Ibaraki 305-0801 (Japan)

2014-02-11

Impedance matching of RF windows that minimizes the RF reflection is necessary to prevent localized standing waves between an RF window and a cavity, which may cause thermal and/or multipactoring issues. It has been observed that the impedance matching condition of the pillbox-type RF window, checked by voltage standing wave ratio (VSWR) measurement, depends on the manufacturing lot of the window ceramic disk made of 95% purity Al{sub 2}O{sub 3}. The present report proposes new procedures for impedance matching as follows: (i) The relative dielectric constant of the ceramic window is directly measured using the resonant frequency of a cavity made by temporarily combining the pillbox part of the RF window and two short-circuiting plates. (ii) The dimensions of the pillbox section including the ceramic disk are fixed on the basis of the measured relative dielectric constant. To confirm this procedure, three RF windows were fabricated using the same type of ceramic material, and successful impedance matching of these windows was performed (VSWR<1.05). The measured results also suggest that the relative dielectric constant increases linearly with increasing density and that the impedance matching condition is mainly affected by variations of the relative dielectric constant due to shrinkage of the alumina during sintering. -- Highlights: • We measured the relative dielectric constant of an RF window ceramic directly. • We used the circular TE011-mode frequency of the pillbox part of an RF window itself. • The dimensions of the pillbox part were fixed on the basis of the measurement result. • Three RF windows were fabricated, and VSWR <1.05 for these windows was performed. • The relative dielectric constant increases linearly with increasing ceramic density.

Impedance matching of pillbox-type RF windows and direct measurement of the ceramic relative dielectric constant

International Nuclear Information System (INIS)

Ao, Hiroyuki; Asano, Hiroyuki; Naito, Fujio; Ouchi, Nobuo; Tamura, Jun; Takata, Koji

2014-01-01

Impedance matching of RF windows that minimizes the RF reflection is necessary to prevent localized standing waves between an RF window and a cavity, which may cause thermal and/or multipactoring issues. It has been observed that the impedance matching condition of the pillbox-type RF window, checked by voltage standing wave ratio (VSWR) measurement, depends on the manufacturing lot of the window ceramic disk made of 95% purity Al 2 O 3 . The present report proposes new procedures for impedance matching as follows: (i) The relative dielectric constant of the ceramic window is directly measured using the resonant frequency of a cavity made by temporarily combining the pillbox part of the RF window and two short-circuiting plates. (ii) The dimensions of the pillbox section including the ceramic disk are fixed on the basis of the measured relative dielectric constant. To confirm this procedure, three RF windows were fabricated using the same type of ceramic material, and successful impedance matching of these windows was performed (VSWR<1.05). The measured results also suggest that the relative dielectric constant increases linearly with increasing density and that the impedance matching condition is mainly affected by variations of the relative dielectric constant due to shrinkage of the alumina during sintering. -- Highlights: • We measured the relative dielectric constant of an RF window ceramic directly. • We used the circular TE011-mode frequency of the pillbox part of an RF window itself. • The dimensions of the pillbox part were fixed on the basis of the measurement result. • Three RF windows were fabricated, and VSWR <1.05 for these windows was performed. • The relative dielectric constant increases linearly with increasing ceramic density

Oberflächenveränderung verschiedener zahnmedizinischer Werk-stoffe nach in-vitro Alterung

OpenAIRE

Kuster, Daniela

2014-01-01

Susceptibility of different restorative materials to toothbrush abrasion and coffee staining Objective: The aim of this study was to evaluate the susceptibility of different restorative materials to surface alterations after an aging simulation. Methods: Specimens (n=15 per material) of five different restorative materials (CER: ceramic/Vita Mark II; EMP: composite/Empress Direct; LAV: CAD/CAM composite/Lava Ultimate; COM: prefabricated composite/Componeer; VEN: prefabricated composite/...

Anfangen, sich die Welt anders vorzustellen Beginning to Imagine the World Differently

Directory of Open Access Journals (Sweden)

Sabine Fuchs

2006-11-01

Full Text Available Der Sammelband Butler Matters bezeugt Judith Butlers außerordentliche Bedeutung für feministische und queere Studien und Forschung. In elf Beiträgen wird Butlers (frühes Werk von Gender Trouble und Bodies That Matter über Excitable Speech bis zu The Psychic Life of Power betrachtet und sein weit reichender Einfluss quer durch die wissenschaftlichen Disziplinen nachgewiesen. Dargestellt werden auch die kontroverse Rezeption von Butlers Werk sowie die politischen Wirkungen von Butlers Denken. Besonders anregend ist ein zweiteiliges Interview mit Judith Butler, in dem sie auf ein breites Spektrum von Fragen eingeht, die auch wichtige Themen ihrer aktuelleren Werke betreffen.The collected volume Butler Matters testifies to Judith Butler’s extraordinary importance for feminist and queer studies and for gender research. The eleven contributions examine Butler’s (early work—including Gender Trouble, Bodies that Matter, Excitable Speech, and The Psychic Life of Power—and prove its expansive influence across scholarly disciplines. The volume also portrays the controversial reception of Butler’s work as well as the political ramifications of her thinking. A two-part interview with Judith Butler, in which she approaches questions on a broad spectrum including important themes concerning her recent work, is particularly inspiring.

Types of suggestibility: Relationships among compliance, indirect, and direct suggestibility.

Science.gov (United States)

Polczyk, Romuald; Pasek, Tomasz

2006-10-01

It is commonly believed that direct suggestibility, referring to overt influence, and indirect suggestibility, in which the intention to influence is hidden, correlate poorly. This study demonstrates that they are substantially related, provided that they tap similar areas of influence. Test results from 103 students, 55 women and 48 men, were entered into regression analyses. Indirect suggestibility, as measured by the Sensory Suggestibility Scale for Groups, and compliance, measured by the Gudjonsson Compliance Scale, were predictors of direct suggestibility, assessed with the Barber Suggestibility Scale. Spectral analyses showed that indirect suggestibility is more related to difficult tasks on the BSS, but compliance is more related to easy tasks on this scale.

Co-clustering directed graphs to discover asymmetries and directional communities.

Science.gov (United States)

Rohe, Karl; Qin, Tai; Yu, Bin

2016-10-21

In directed graphs, relationships are asymmetric and these asymmetries contain essential structural information about the graph. Directed relationships lead to a new type of clustering that is not feasible in undirected graphs. We propose a spectral co-clustering algorithm called di-sim for asymmetry discovery and directional clustering. A Stochastic co-Blockmodel is introduced to show favorable properties of di-sim To account for the sparse and highly heterogeneous nature of directed networks, di-sim uses the regularized graph Laplacian and projects the rows of the eigenvector matrix onto the sphere. A nodewise asymmetry score and di-sim are used to analyze the clustering asymmetries in the networks of Enron emails, political blogs, and the Caenorhabditis elegans chemical connectome. In each example, a subset of nodes have clustering asymmetries; these nodes send edges to one cluster, but receive edges from another cluster. Such nodes yield insightful information (e.g., communication bottlenecks) about directed networks, but are missed if the analysis ignores edge direction.

Direct costs associated with chronic kidney disease among type 2 diabetic patients in India

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K Satyavani

2014-01-01

Full Text Available The aim of this study was to estimate the direct costs of medical care among hospitalized type 2 diabetic patients with chronic kidney disease (CKD. A total of 209 (M:F, 133:76 patients were divided into groups based on the severity of kidney disease. Group 1 subjects had undergone renal transplantation (n = 12, group 2 was CKD patients on hemodialysis (n = 45, group 3 was patients with CKD, prior to end-stage renal disease (ESRD (n = 66, and group 4 (n = 86 consisted of subjects without any complications. Details about expenditure per hospitalization, length of stay during admission, direct medical and nonmedical cost, expenditure for the previous two years, and source of bearing the expenditure were recorded in a questionnaire. Diabetic patients with CKD prior to ESRD spend more per hospitalization than patients without any complications. [Median ₹ 12,664 vs. 3,214]. The total median cost of CKD patients on hemodialysis was significantly higher than other CKD patients (INR 61,170 vs. 12,664. The median cost involved in kidney transplantation was ₹ 392,920. The total expenditure for hospital admissions in two years was significantly higher for dialysis than transplantation. Patients on hemodialysis or kidney transplantation tend to stay longer as inpatient admissions. The source of funds for the expenditure was mainly personal savings (46%. The expenditure on hospital admissions for CKD was considerably higher, and so, there is a need to develop a protocol on a cost-effective strategy for the treatment of CKD.

The n-type conduction of indium-doped Cu{sub 2}O thin films fabricated by direct current magnetron co-sputtering

Energy Technology Data Exchange (ETDEWEB)

Cai, Xing-Min; Su, Xiao-Qiang; Ye, Fan, E-mail: yefan@szu.edu.cn; Wang, Huan; Tian, Xiao-Qing; Zhang, Dong-Ping; Fan, Ping; Luo, Jing-Ting; Zheng, Zhuang-Hao; Liang, Guang-Xing [Institute of Thin Film Physics and Applications, School of Physical Science and Technology and Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060 (China); Roy, V. A. L. [Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong (China)

2015-08-24

Indium-doped Cu{sub 2}O thin films were fabricated on K9 glass substrates by direct current magnetron co-sputtering in an atmosphere of Ar and O{sub 2}. Metallic copper and indium disks were used as the targets. X-ray diffraction showed that the diffraction peaks could only be indexed to simple cubic Cu{sub 2}O, with no other phases detected. Indium atoms exist as In{sup 3+} in Cu{sub 2}O. Ultraviolet-visible spectroscopy showed that the transmittance of the samples was relatively high and that indium doping increased the optical band gaps. The Hall effect measurement showed that the samples were n-type semiconductors at room temperature. The Seebeck effect test showed that the films were n-type semiconductors near or over room temperature (<400 K), changing to p-type at relatively high temperatures. The conduction by the samples in the temperature range of the n-type was due to thermal band conduction and the donor energy level was estimated to be 620.2–713.8 meV below the conduction band. The theoretical calculation showed that indium doping can raise the Fermi energy level of Cu{sub 2}O and, therefore, lead to n-type conduction.

Digital Transformation Canvas - Übersicht behalten und Handlungsfelder gestalten

Science.gov (United States)

Köster, Michael; Mache, Tobias

Im Beitrag "Digital Transformation Canvas - Übersicht behalten und Handlungsfelder gestalten" wird zunächst grob auf die wesentlichen Herausforderungen, die mit der zunehmenden Digitalisierung einhergehen, eingegangen. Anschließend werden ausgewählte Konzepte des Business Transformation Management vorgestellt, die sich mit der grundlegenden Weiterentwicklung von Organisationen - wie es die Digitalisierung erfordert - auseinandersetzen. Eine detaillierte Einführung in die Methodik des Business Transformation Canvas, der sich mit den unterschiedlichsten Gestaltungsfeldern der Transformation auseinandersetzt und ein Framework für Transformationsprojekte darstellt, rundet den Beitrag ab. Er schließt mit einem Fazit und Ausblick.

The Number of Response Categories and the Reverse Directional Item Problem in Likert-Type Scales: A Study with the Rasch Model

Directory of Open Access Journals (Sweden)

Mustafa İLHAN

2017-09-01

Full Text Available This study addressed reverse directional item and the number of response categories problems in Likert-type scales. The Fear of Negative Evaluation Scale (FNES and the Oxford Happiness Questionnaire (OHQ were used as data collection tools. The data of the study were analyzed according to the Rasch model. The analysis found that the observed and expected test characteristic curves were largely overlapped, each of the three rating scales worked effectively, and the differences between response categories could be distinguished successfully by the participants in straightforward directional items. On the other hand, it was determined that there were significant differences between the observed and expected test characteristic curves in reverse directional items. It was also found that no matter which one of these three, five and seven-point rating scales was used, the participants could not distinguish the response categories of the reverse directional items on the FNES and the OHQ. Afterwards, the reverse directional items were removed from the data file, and the analysis was repeated. The analysis results revealed that item discrimination, reliability coefficients for person facet, separation ratios and Chi square values calculated for the facets of person and items were higher in five-pointed rating compared to three and seven pointed rating.

Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor

DEFF Research Database (Denmark)

Kulahin, Nikolaj; Li, Shizhong; Hinsby, Anders Mørkeberg

2008-01-01

The neuronal cell adhesion molecule (CAM) L1 promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). The present study demonstrates a direct interaction between L1 fibronectin type III (FN3) modules I-V and FGFR1 immunoglobulin (Ig) modules II...

DIRECTIONS OF USING DIRECT PAYMENTS BY THE INDIVIDUAL FARMS LOCATED IN CHOSEN REGIONS

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Arkadiusz Sadowski

2012-01-01

Full Text Available This paper assesses the diversity of directions for use of direct payments in different types of individual farms. The questionnaire surveys were performed on 295 farms located in dif-ferent parts of the country. Analysed farms were divided into groups according to the amount direct support received. Based on the survey concluded that in all analysed groups the largest share of direct payments is spent on the purchase of means of production. The smallest farms also spend to a high extent, the money on household purposes (20.5% and the largest ones to finance the investment (17.7%.

Entrance Counseling Guide for Direct Loan Borrowers

Science.gov (United States)

Federal Student Aid, US Department of Education, 2010

2010-01-01

This guide describes the four types of loans offered by the Direct Loan Program[SM]: (1) Direct Subsidized Loans; (2) Direct Unsubsidized Loans; (3) Direct PLUS Loans; and (4) Direct Consolidation Loans. Among the topics covered in the guide are: Use of Your Loan Money, The Master Promissory Note, How Your Loans Will Be Disbursed (Paid Out),…

Modification of Method for Solution of Direct Kinematic Problem for the Type of Platform Manipulators with Six Degrees of Freedom

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A. L. Lapikov

2014-01-01

Full Text Available This paper considers creation of methods for research of multi-section manipulators of parallel structure. To solve this task it is necessary, firstly, to carry out generalization, systematization, and enhancement of existing models of platform manipulators with six degrees of freedom; secondly, it is necessary to modify previously suggested methods for solving the kinematic tasks for the specified type of manipulation mechanisms. The paper presents detailed domain analysis, describes major issues appearing in the course of research, and suggests basic methods of their solution. The paper demonstrates the necessity for modification of existing models through supplementing new parameters. Modification and generalization of the previously suggested method for solution of direct kinematic problem for the specified type of manipulators were carried out. Method for solution of this problem consists in establishing the dependence of functional relationship of Cartesian coordinates and orientation of the moving platform center on the values of generalized coordinates of manipulator (in case of platform manipulators, these are the lengths of telescopic legs connecting the base and the moving platform of the manipulator. The method is created in such a way that solution of direct kinematic problem results in finding of the analytical equation of the plane where the moving platform lies. The equation of the required plane is described through three points (attachment points of the moving platform joints. To define coordinate values of the joints, the system of nine non-linear equations is generated. It should be noted that the system of equations is composed of one-type equations with the same type of nonlinearity. The physical meaning of all the nine equations of the system is Euclidean distance between the points of the manipulator. The location and orientation of the manipulator are depicted as a homogenous transformation matrix. Vectors of translation

Plaadid / Katrin Malt, Virko Pirrus, Mart Kalvet

Index Scriptorium Estoniae

Malt, Katrin

2008-01-01

Uutest heliplaatidest Atrocity "Werk 80 II", Benighted "Icon", Brain Drill "Apocalyptic Feasting", BrainStorm "Downburst", Diablo Swing Orchestra "The Butcher's Ballroom", Floodstain "Dreams Make Monters", Foxy Shazam "Introducting Foxy Shazam"

Rezension zu: Uta Felten, Tanja Schwan (Hg.: Frida Kahlo. Berlin: edition tranvía – Verlag Walter Frey 2008

Directory of Open Access Journals (Sweden)

Tabea Huth

2009-07-01

Full Text Available Im vorliegenden Sammelband bemühen sich die Autor/-innen um eine Neubewertung des Werks der mexikanischen Künstlerin Frida Kahlo (1907–1954 im Kontext aktueller theoretischer Debatten und stellen die Frage nach der Verortung der Künstlerin in der zeitgenössischen mexikanischen und europäischen Kunstszene. Unter der Verwendung von theoretischen Ansätzen aus der Erforschung von Intermedialität, Gender, Performanz und Hybridität sowie Inspirationen aus der postkolonialen Theorie analysieren die Autoren/-innen das Zusammenspiel von Leben, Werk und Rezeption der Künstlerin. Das Interesse an der Inszenierung des fragmentierten weiblichen Körpers im Kontext kultureller Hybridität verbindet die einzelnen Aufsätze – was leider im Titel des Bandes nicht ganz deutlich wird.

Optimal management of the power distribution network. A novel network information system; Optimale Verwaltung des Versorgungsnetzes. Ein neues Netzinformationssystem

Energy Technology Data Exchange (ETDEWEB)

Kiesel, U. [HEW AG, Hamburg (Germany); Korri, P. [Tekla Qyj, Eschborn (Germany). Energieversorgung

2000-12-01

In June 200, the German electric utility Hamburgische Electricitaets-Werke AG (HEW) has bought and installed a high-performance, PC-based information system for all purposes of distribution network management tasks for their medium and low-voltage grids. The standard software Xpower of the Finnish software house Tekla Oyj has been streamlined with the requirements of the utility and is described with respect to the applications on site. (orig./CB) [German] Mit der Einfuehrung eines Netzinformationssystems (NIS) steht der Hamburgischen Electricitaets-Werke AG (HEW) seit Juni 2000 ein leistungsstarkes PC-basiertes Informationssystem zur Verfuegung, das langfristig die Projektierung und die Betriebsfuehrung der Mittel- und Niederspannungsnetze unterstuetzt und dokumentiert. Die Standardsoftware Xpower des finnischen Spezialisten Tekla Oyj wurde an die Anforderungen der HEW angepasst. (orig./CB)

Leipoldt in 1980*

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H. M. Viljoen

1980-03-01

Full Text Available Oor Leipoldt se veelsydigheid hoef daar nie veel gésê te word nie. Hy was digter, dramaturg, romanskrywer, joemalis, geneesheer, kos- en wynkenner, filantroop, wêreldburger, maar bly tog vir ons in die eerste plek digter. Ons beeld van Leipoldt so oeuvre kan verander - daar is vanjaar al twee “nuwe” werke van hom ontdek - maar as daar iets van Leipoldt behoue sal bly, sal dit eerder sy poësie as sy drama, prosa, joemalistieke werk of kookboeke wees; so lyk dit altans op die oomblik. Daarom beperk ek my to t sy poësie en sal ek nie probeer om u totaalbeeld van sy ryk maar erg ongelyke oeuvre te gee nie.

78 FR 49753 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2013-08-15

... KSTW Holdings, Inc.; Steinway Musical Instruments, Inc.; KSTW Holdings, Inc. 20131063 G Quad-C Partners...; Marketing Werks, Inc.; WP Horizon Topco LLC. 07/23/2013 20131051 G Novo Nordisk Foundation; Ophthotech...

Hans-Heinrich Nolte (Hg.), Klaas Bähre (Red.), Innere Peripherien in Ost und West / [rezensiert von] Helmut Klüter

OpenAIRE

Klüter, Helmut

2008-01-01

Rezensiertes Werk: Innere Peripherien in Ost und West / Hrsg.: Hans-Heinrich Nolte. Red.: Klaas Bähre. - Stuttgart : Steiner, 2001. - 187 S. : Kt. - (Historische Mitteilungen : Beiheft ; 42) ISBN 3-515-07972-6

A tactile P300 brain-computer interface

NARCIS (Netherlands)

Brouwer, A.M.; Erp, J.B.F. van

2010-01-01

De werking van de eerste Brain-Computer-Interface gebaseerd op tactiele EEG response wordt gedemonstreerd en het effect van het aantal gebruikte vibro-tactiele tactoren en stimulus-timing parameters wordt onderzocht

The direct economic impact of alternative types of the rural tourism

Directory of Open Access Journals (Sweden)

Simona Miškolci

2005-01-01

Full Text Available Rural tourism has come to occupy a prominent position in the debate about rural restructuring in all OECD countries, partly because of demand changes which favour rural tourism and partly because rural agencies recognise a need to provide economic activities with potential for growth in a rural economy in which traditional providers of rural employment (such as agriculture have been shedding labour at a rapid rate. Well-designed strategy is essential to its success in impacting on the rural economy. The structures for collaboration and co-operation must be developed and combined with a process of education and training. Co-operative effort must be effective and sustainable. The tourism related businesses should not be isolated from the larger community and its issues.The principal motivation for a community, business or region to serve tourists is generally economic. An individual business is interested primarily in its own revenues and costs, while a community or region is concerned with tourism’s overall contribution to the economy, as well as social, fiscal and environmental impacts. A good understanding of tourism’s economic impacts is therefore important for the tourism industry, government officials, and the community as a whole.The principal objective of the study, that is reported here, was to determine the potential income of farmers from the provision of agro-tourism services. First, the paper reviews selected results of the visitor spending survey in alternative types of rural tourism of the region Southeast (Czech Republic; second the direct economic benefit of the agro-tourism in this region is estimated, and finally, critical factors reducing the effectiveness of agro-tourism as a rural development instrument are drawn.

Studies on the effect of radio frequency field in a cusp-type charge separation device for direct energy conversion

International Nuclear Information System (INIS)

Hamabe, Masaki; Izawa, Hiroaki; Takeno, Hiromasa; Nakamoto, Satoshi; Ichimura, Kazuya; Nakashima, Yousuke

2016-01-01

In D- 3 He fusion power generation, an application of direct energy conversion is expected in which separation of charged particles is necessary. A cusp-type direct energy converter (CuspDEC) was proposed as a charge separation device, but its performance was degraded for a high density plasma. The goal of the present study is to establish an additional method to assist charge separation by using a nonlinear effect of a radio frequency (rf) electric field. Following to the previous study, we experimentally examine the effect of an rf field to electron motion in a CuspDEC device. Two ring electrodes were newly installed in a CuspDEC simulator and the current flowing into the electron collector located in the line cusp region was measured on an rf field application. The significant variation in the current was found, and an improvement of the charge separation can be expected by using the phenomenon appropriately. (author)

Recht autonom

Directory of Open Access Journals (Sweden)

Robert von Friedeburg

2010-01-01

Full Text Available Rezensiertes Werk: Christopher W. Brooks, Law, Politics and Society in Early Modern England, Cambridge [u. a.]: Cambridge University Press 2008, XII, 456 S., ISBN 978-0-521-32391-8

Unglückbringende Sprachen

Directory of Open Access Journals (Sweden)

Gabriele von Olberg-Haverkate

2010-01-01

Full Text Available Rezensiertes Werk: Peter Friedrich, Manfred Schneider (Hg., Fatale Sprachen. Eid und Fluch in Literaturund Rechtsgeschichte, Paderborn, München: Wilhelm Fink 2009, 348 S., ISBN 978-3-7705-4740-1

CO{sub 2} direct cycles suitable for AGR type reactors; Cycles directs de gaz carbonique applicables aux reacteurs du genre AGR

Energy Technology Data Exchange (ETDEWEB)

Maillet, E [Commissariat a l' Energie Atomique. Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1967-10-01

The perspectives given by the gas turbines under pressure, to build simple nuclear power plants and acieving significantly high yield, are specified. The CO{sub 2} is characterised by by good efficiency under moderate temperature (500 to 750 Celsius degrees), compactness and the simpleness of machines and the safe exploitation (supply, storage, relief cooling, thermosyphon). The revision of thermal properties of the CO{sub 2} and loss elements show that several direct cycles would fit in particular to the AGR type reactors. Cycles that would diverge a little from classical models and able to lead to power and heat generation can lead by simple means to the best results. Several satisfying solutions present for the starting up, the power regulation and the stopping. The nuclear power plant components and the functioning safety are equally considered in the present report. The conclusions stimulate the studies and realizations of carbon dioxide gas turbines in when approprite. [French] Les perspectives offertes par la turbine a gaz sous pression, pour construire des centrales nucleaires simples et de rendement progressivement eleve, se precisent actuellement. le CO{sub 2} se distingue par sa bonne efficacite a temperature moderee (500 a 750 degres celsius), la compacite et la simplicite des machines, et la surete qu'il apporte a l'exploitation ( approvisionnement, stockage, refroidissement de secours, thermosiphon). La revision des proprietes thermophysiques du CO{sub 2} et des elements de pertes montre que divers cycles directs conviendraient en particulier aux reacteurs agr ou derives. Des cycles s'ecartant peu des modeles classiques, et se pretant ulterieurement a la production simultanee d'electricite et de chaleur, peuvent conduire par des moyens simples aux meilleurs resultats d'ensemble. Plusieurs solutions satisfaisantes se presentent pour le demarrage, le reglage de la puissance et l'arret. Les composants de la centrale et la surete de fonctionnement sont

Dichtung als Blüte der Wahrheit Fiction as Blossom of Truth

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Susanne Gramatzki

2006-03-01

Full Text Available Kaum eine andere Schriftstellerin hat so konsequent – man ist versucht, zu sagen: so ernsthaft – mit fremden Identitäten gespielt wie Else Lasker-Schüler, die sich selbst als Tino von Bagdad oder Prinz Jussuf von Theben imaginierte und ihren Freunden erfindungsreiche Namen beilegte. Realität und Phantasie flossen in ihrem Leben und Werk stets zusammen. Sigrid Bauschinger, ehemalige Professorin an der University of Massachusetts und bereits 1980 mit einer umfangreichen Studie über Else Lasker-Schüler hervorgetreten (Else Lasker-Schüler. Ihr Werk und ihre Zeit, hat es nun unternommen, auf Grundlage bisher unveröffentlicher Dokumente eine neue Biographie der bedeutenden Wuppertaler Autorin zu verfassen.Almost no other female author has played with foreign identities as consistently—one could almost say as seriously—as Else Lasker-Schüler, who fashioned herself as Tino von Baghdad or Prince Jussuf von Theben and affixed her friends with imaginative names. Reality and fantasy were intertwined in her life and work. Sigrid Bauschinger, formerly professor at the University of Massachusetts, already presented a comprehensive study of Else Lasker-Schüler in 1980 (Else Lasker-Schüler. Ihr Werk und ihre Zeit/Else Lasker-Schüler. Her Work and Her Time. She has now written a new biography of the Wuppertal author based on previously unpublished documents.

Beats on the Table: Beat Writing in the Chicago Review and Big Table

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Jaap van der Bent

2012-07-01

Full Text Available Normal 0 21 false false false NL X-NONE X-NONE MicrosoftInternetExplorer4 Kleine literaire tijdschriften, zogenaamde little magazines, hebben een belangrijke rol gespeeld bij de doorbraak, in de loop van de jaren vijftig, van de Amerikaanse Beat Generation. Aangezien grotere uitgeverijen en de gevestigde tijdschriften lange tijd terugschrokken voor de zowel inhoudelijk als formeel van de norm afwijkende uitingen van de Beats, verscheen hun werk aanvankelijk vooral in kleinere tijdschriften als de twee waaraan in dit artikel aandacht wordt besteed: de Chicago Review en Big Table. Aan de hand van een beschrijving van de inhoud van deze twee tijdschriften wordt geprobeerd duidelijk te maken hoe het werk van de Beat Generation zich in deze tijdschriften gaandeweg een eigen plaats verwierf. Speciale aandacht wordt besteed aan de rol van de redacteuren Irving Rosenthal en Paul Carroll; door zijn uitgekiende strategie om voor het omstreden werk van Beat-auteur William S. Burroughs geleidelijk een steeds grotere plaats in te ruimen, bepaalde vooral Rosenthal het veranderende karakter van de Chicago Review. De veranderingen bij dat tijdschrift verliepen niet zonder slag of stoot en waren voor de eigenaar ervan, de University of Chicago, op een gegeven moment aanleiding om de Chicago Review aan censuur te onderwerpen. Ook deze censuur en de reactie erop, de oprichting van Big Table, worden in het artikel belicht.

Replicative Intermediates of Human Papillomavirus Type 11 in Laryngeal Papillomas: Site of Replication Initiation and Direction of Replication

Science.gov (United States)

Auborn, K. J.; Little, R. D.; Platt, T. H. K.; Vaccariello, M. A.; Schildkraut, C. L.

1994-07-01

We have examined the structures of replication intermediates from the human papillomavirus type 11 genome in DNA extracted from papilloma lesions (laryngeal papillomas). The sites of replication initiation and termination utilized in vivo were mapped by using neutral/neutral and neutral/alkaline two-dimensional agarose gel electrophoresis methods. Initiation of replication was detected in or very close to the upstream regulatory region (URR; the noncoding, regulatory sequences upstream of the open reading frames in the papillomavirus genome). We also show that replication forks proceed bidirectionally from the origin and converge 180circ opposite the URR. These results demonstrate the feasibility of analysis of replication of viral genomes directly from infected tissue.

Everything-as-it-should-be-Blackstone?

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Kent D. Lerch

2010-01-01

Full Text Available Rezensiertes Werk: Wilfrid R. Prest, William Blackstone. Law and Letters in the Eighteenth Century, Oxford [u. a.]: Oxford University Press 2008, XVII, 355 S., ISBN 978-0-19-955029-6

Nicht nur böse Christen

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Andreas Thier

2003-01-01

Full Text Available Rezensiertes Werk: John Witte jr., Law and Protestantism. The Legal Teachings of the Lutheran Reformation, New York, Cambridge: Cambridge University Press 2002, XX, 337 S., ISBN 0-521-78132-9

Second harmonic generation microscopy differentiates collagen type I and type III in COPD

Science.gov (United States)

Suzuki, Masaru; Kayra, Damian; Elliott, W. Mark; Hogg, James C.; Abraham, Thomas

2012-03-01

The structural remodeling of extracellular matrix proteins in peripheral lung region is an important feature in chronic obstructive pulmonary disease (COPD). Multiphoton microscopy is capable of inducing specific second harmonic generation (SHG) signal from non-centrosymmetric structural proteins such as fibrillar collagens. In this study, SHG microscopy was used to examine structural remodeling of the fibrillar collagens in human lungs undergoing emphysematous destruction (n=2). The SHG signals originating from these diseased lung thin sections from base to apex (n=16) were captured simultaneously in both forward and backward directions. We found that the SHG images detected in the forward direction showed well-developed and well-structured thick collagen fibers while the SHG images detected in the backward direction showed striking different morphological features which included the diffused pattern of forward detected structures plus other forms of collagen structures. Comparison of these images with the wellestablished immunohistochemical staining indicated that the structures detected in the forward direction are primarily the thick collagen type I fibers and the structures identified in the backward direction are diffusive structures of forward detected collagen type I plus collagen type III. In conclusion, we here demonstrate the feasibility of SHG microscopy in differentiating fibrillar collagen subtypes and understanding their remodeling in diseased lung tissues.

X-ray-to-current signal conversion characteristics of trench-structured photodiodes for direct-conversion-type silicon X-ray sensor

International Nuclear Information System (INIS)

Ariyoshi, Tetsuya; Funaki, Shota; Sakamoto, Kenji; Baba, Akiyoshi; Arima, Yutaka

2017-01-01

To reduce the radiation dose required in medical X-ray diagnoses, we propose a high-sensitivity direct-conversion-type silicon X-ray sensor that uses trench-structured photodiodes. This sensor is advantageous in terms of its long device lifetime, noise immunity, and low power consumption because of its low bias voltage. With this sensor, it is possible to detect X-rays with almost 100% efficiency; sensitivity can therefore be improved by approximately 10 times when compared with conventional indirect-conversion-type sensors. In this study, a test chip was fabricated using a single-poly single-metal 0.35 μm process. The formed trench photodiodes for the X-ray sensor were approximately 170 and 300 μm deep. At a bias voltage of 25 V, the absorbed X-ray-to-current signal conversion efficiencies were 89.3% (theoretical limit; 96.7%) at a trench depth of 170 μm and 91.1% (theoretical limit; 94.3%) at a trench depth of 300 μm. (author)

Direct Synthesis of Carbon Nanotube Field Emitters on Metal Substrate for Open-Type X-ray Source in Medical Imaging

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Amar Prasad Gupta

2017-07-01

Full Text Available We report the design, fabrication and characterization of a carbon nanotube enabled open-type X-ray system for medical imaging. We directly grew the carbon nanotubes used as electron emitter for electron gun on a non-polished raw metallic rectangular-rounded substrate with an area of 0.1377 cm2 through a plasma enhanced chemical vapor deposition system. The stable field emission properties with triode electrodes after electrical aging treatment showed an anode emission current of 0.63 mA at a gate field of 7.51 V/μm. The 4.5-inch cubic shape open type X-ray system was developed consisting of an X-ray aperture, a vacuum part, an anode high voltage part, and a field emission electron gun including three electrodes with focusing, gate and cathode electrodes. Using this system, we obtained high-resolution X-ray images accelerated at 42–70 kV voltage by digital switching control between emitter and ground electrode.

Direct Synthesis of Carbon Nanotube Field Emitters on Metal Substrate for Open-Type X-ray Source in Medical Imaging.

Science.gov (United States)

Gupta, Amar Prasad; Park, Sangjun; Yeo, Seung Jun; Jung, Jaeik; Cho, Chonggil; Paik, Sang Hyun; Park, Hunkuk; Cho, Young Chul; Kim, Seung Hoon; Shin, Ji Hoon; Ahn, Jeung Sun; Ryu, Jehwang

2017-07-29

We report the design, fabrication and characterization of a carbon nanotube enabled open-type X-ray system for medical imaging. We directly grew the carbon nanotubes used as electron emitter for electron gun on a non-polished raw metallic rectangular-rounded substrate with an area of 0.1377 cm² through a plasma enhanced chemical vapor deposition system. The stable field emission properties with triode electrodes after electrical aging treatment showed an anode emission current of 0.63 mA at a gate field of 7.51 V/μm. The 4.5-inch cubic shape open type X-ray system was developed consisting of an X-ray aperture, a vacuum part, an anode high voltage part, and a field emission electron gun including three electrodes with focusing, gate and cathode electrodes. Using this system, we obtained high-resolution X-ray images accelerated at 42-70 kV voltage by digital switching control between emitter and ground electrode.

Budke, Alexandra; Kanwischer, Detlef; Pott, Andreas (Hg.), Internetgeographien : Beobachtungen zum Verhältnis von Internet, Raum und Gesellschaft / [rezensiert von] Helmut Klüter

OpenAIRE

Klüter, Helmut

2009-01-01

Rezensiertes Werk: Internetgeographien : Beobachtungen zum Verhältnis von Internet, Raum und Gesellschaft / hrsg. von Alexandra Budke ... - Stuttgart : Steiner, 2004. - 192 S. : Ill., graph. Darst., Kt. - (Erdkundliches Wissen ; 136) ISBN 3-515-08506-8

Allwissende Kollegen

Directory of Open Access Journals (Sweden)

Valentin Groebner

2008-01-01

Full Text Available Rezensiertes Werk:Jaana Eichhorn, Geschichtswissenschaft zwischen Tradition und Innovation. Diskurse, Institutionen und Machtstrukturen der bundesdeutschen Frühneuzeitforschung, Göttingen: Vandenhoeck Ruprecht 2006, 476S., ISBN 978-3-89971-294-0

Verlies van (thuis en haard. Het belang van verliesbegeleiding als onderdeel van de maatschappelijke begeleiding binnen het Vluchtelingenwerk, regio Utrecht

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Birgit Hoogenberk

2014-06-01

Full Text Available Loss of home and house. The importance of loss counseling as a part of refugee social supportIn this article it is advocated that it is important that the implementation of loss counseling is part of social support for refugees, also called integrative eclectic working. Social support from VluchtelingenWerk, also known as Refugee Council, is about supporting the client in an effective manner with their personal problems which can hinder their integration. Because the target group of VluchtelingenWerk is a group of people whom have suffered many losses, attention should be brought to this subject. Unfortunately in current work methods there is no room for loss counseling, partly due to the lack of methodological tools. The losses associated with this group have a lot of impact on their daily lives and often are the source of functional limitations. By offering loss counseling and multi-method grief counseling, volunteers and employees are offered tools to make loss more negotiable. In this article different examples will be discussed and the new loss model of Stroebe and Schut will be explained. What will be clarified is the importance of the implementation of loss counseling, for the well-being and the integration process of clients as well as achieving organizational goals.Verlies van (thuis en haard. Het belang van verliesbegeleiding als onderdeel van de maatschappelijke begeleiding binnen het VluchtelingenWerk, regio UtrechtIn dit artikel wordt gepleit voor het implementeren van verliesbegeleiding als onderdeel van de maatschappelijke begeleiding, er is sprake van integratief eclectisch werken. De maatschappelijke begeleiding van het VluchtelingenWerk heeft als taak de cliënt zo goed mogelijk te begeleiden bij persoonlijke problemen die de inburgering kunnen belemmeren. Aangezien de doelgroep van het VluchtelingenWerk bestaat uit mensen die ontzettend veel verliezen hebben geleden dient hier aandacht voor te zijn. Helaas is in de huidige

Healthcare resource use, direct and indirect costs of hypoglycemia in type 1 and type 2 diabetes, and nationwide projections. Results of the HYPOS-1 study.

Science.gov (United States)

Giorda, C B; Rossi, M C; Ozzello, O; Gentile, S; Aglialoro, A; Chiambretti, A; Baccetti, F; Gentile, F M; Romeo, F; Lucisano, G; Nicolucci, A

2017-03-01

To obtain an accurate picture of the total costs of hypoglycemia, including the indirect costs and comparing the differences between type 1 (T1DM) and type 2 diabetes mellitus (T2DM). HYPOS-1 was a multicenter, retrospective cohort study which analyzed the data of 2229 consecutive patients seen at 18 diabetes clinics. Data on healthcare resource use and indirect costs by diabetes type were collected via a questionnaire. The domains of inpatient admission and hospital stay, work days lost, and third-party assistance were also explored. Resource utilization was reported as estimated incidence rates (IRs) of hypoglycemic episodes per 100 person-years and estimated costs as IRs per person-years. For every 100 patients with T1DM, 9 emergency room (ER) visits and 6 emergency medical service calls for hypoglycemia were required per year; for every 100 patients with T2DM, 3 ER visits and 1 inpatient admission were required, with over 3 nights spent in hospital. Hypoglycemia led to 58 work days per 100 person-years lost by the patient or a family member in T1DM versus 19 in T2DM. The costs in T1DM totaled €90.99 per person-year and €62.04 in T2DM. Direct and indirect costs making up the total differed by type of diabetes (60% indirect costs in T1DM versus 43% in T2DM). The total cost associated with hypoglycemia in Italy is estimated to be €107 million per year. Indirect costs meaningfully contribute to the total costs associated with hypoglycemia. As compared with T1DM, T2DM requires fewer ER visits and incurs lower indirect costs but more frequent hospital use. Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Modulation of intracellular Ca2+ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the alpha1-adrenoceptors.

Science.gov (United States)

Bkaily, Ghassan; El-Bizri, Nesrine; Bui, Michel; Sukarieh, Rami; Jacques, Danielle; Fu, Michael L X

2003-03-01

The effects of methoxamine, a selective alpha1-adrenergic receptor agonist, and the autoantibody directed against the second extracellular loop of alpha1-adrenoceptors were studied on intracellular free Ca2+ levels using confocal microscopy and ionic currents using the whole-cell patch clamp technique in single cells of 10-day-old embryonic chick and 20-week-old fetal human hearts. We observed that like methoxamine, the autoantibody directed against the second extracellular loop of alpha1-adrenoreceptors significantly increased the L-type calcium current (I(Ca(L))) but had no effect on the T-type calcium current (I(Ca(T))), the delayed outward potassium current, or the fast sodium current. This effect of the autoantibody was prevented by a prestimulation of the receptors with methoxamine and vice versa. Moreover, treating the cells with prazosin, a selective alpha1-adrenergic receptor antagonist blocked the methoxamine and the autoantibody-induced increase in I(Ca(L)), respectively. In absence of prazosin, both methoxamine and the autoantibody showed a substantial enhancement in the frequency of cell contraction and that of the concomitant cytosolic and nuclear free Ca2+ variations. The subsequent addition of nifedipine, a specific L-type Ca2+ channel blocker, reversed not only the methoxamine or the autoantibody-induced effect but also completely abolished cell contraction. These results demonstrated that functional alpha1-adrenoceptors exist in both 10-day-old embryonic chick and 20-week-old human fetal hearts and that the autoantibody directed against the second extracellular loop of this type of receptors plays an important role in stimulating their activity via activation of L-type calcium channels. This loop seems to have a functional significance by being the target of alpha1-receptor agonists like methoxamine.

49th report of the Arbeitsgemeinschaft Rhein-Wasserwerke e.V.. Annual report 1992

International Nuclear Information System (INIS)

1992-01-01

The annual report of the Arbeitsgemeinschaft Rhein-Wasserwerke (ARW) discusses the following subjects: (1) ARW report on water quality; (2) the problem of herbicides and pesticides; (3) Duesseldorf-Flehe Rhine river monitoring station - construction and performance; (4) observations concerning the aerobic degradation capacity of the river banks as a functional of the seasonal temperature variations of the Rhine; (5) results of Rhine water analyses of GEW-Werke Koeln AG in 1992; (6) statistical methods of generating groundwater levels in ground water aquifers under the influence of outfall ditches. The appendix contains the analyses of the year 1992, the data acquired by GEW-Werke Koeln AG for 1992, the 1993 monitoring programme, and a survey of the organisational structure of the Arbeitsgemeinschaft Rhein-Wasserwerke e.V. (orig./BRR) [de

Besseres Strafrecht?

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Sven Korzilius

2010-01-01

Full Text Available Rezensiertes Werk:Erich Buchholz, Strafrecht im Osten. Ein Abriss über die Geschichte des Strafrechts in der DDR (Edition Zeitgeschichte 37, Berlin: Homilius 2008, 661 S., ISBN 978-3-89706-857-5

Analysis of low-molecular weight radiolysis products in extracts of gamma-irradiated polymers by gas chromatography and high-performance liquid chromatography

International Nuclear Information System (INIS)

Buchalla, Rainer; Begley, Timothy H.; Morehouse, Kim M.

2002-01-01

Estimating exposure to radiolysis products of polymers is an important part of the regulatory evaluation of packaging materials for use in food irradiation. However, as Koni Grob recently put it, the comprehensive analysis of migrants is a challenge. This paper discusses some of the analytical difficulties and presents results obtained with extracts of irradiated polystyrene and polyamide-6. The results indicate that headspace or thermal desorption techniques may, in some instances, lead to an overestimation of radiolysis product concentrations. It is concluded that validated analytical methods and a better understanding of the underlying radiation chemistry would greatly facilitate the safety assessment of irradiated packaging materials

Muentz-Szasz type approximation in direct products of spaces

International Nuclear Information System (INIS)

Sedletskii, A M

2006-01-01

We consider the problem of completeness of the system of exponentials exp{-λ n t}, Re λ n >0, in direct products E=E 1 x E 2 of the spaces E 1 =E 1 (0,1) and E 2 =E 2 (1,∞) of functions defined on (0,1) and (1,∞), respectively. We describe rather broad classes of spaces E 1 and E 2 such that the well-known condition of Szasz is necessary for the completeness of the above system in E and sufficient for this completeness

Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study

DEFF Research Database (Denmark)

Lindhardt, Morten; Persson, Frederik; Zürbig, Petra

2016-01-01

BACKGROUND: Early prevention of diabetic nephropathy is not successful as early interventions have shown conflicting results, partly because of a lack of early and precise indicators of disease development. Urinary proteomics has shown promise in this regard and could identify those at high risk...... who might benefit from treatment. In this study we investigate its utility in a large type 2 diabetic cohort with normoalbuminuria. METHODS: We performed a post hoc analysis in the Diabetic Retinopathy Candesartan Trials (DIRECT-Protect 2 study), a multi centric randomized clinical controlled trial...... = 0.002; cNRI 0.10, P = 0.043). CONCLUSIONS: In this cohort of patients with type 2 diabetes and normoalbuminuria from a large intervention study, the CKD273-classifier was an independent predictor of microalbuminuria. This may help identify high-risk normoalbuminuric patients for preventive...

Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum.

Science.gov (United States)

Wagner, Franz F; Flegel, Willy A; Bittner, Rita; Döscher, Andrea

2017-03-01

Determining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid-cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fy a , Fy b , Jk a and Jk b antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false-negative rate. With fast turnaround times, the rapid-cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting. © 2016 John Wiley & Sons Ltd.

Privacy, werk en internet of things

NARCIS (Netherlands)

Van Der Sype, Yung Shin; Vedder, Anton

2016-01-01

Technologisch zijn ondernemingen nog niet klaar voor 3.0. Hoewel reeds heel wat technische snufjes in de onderneming binnensijpelen, staat de technologie nog niet op punt om al van een Internet of Things te spreken. Dit geeft ons de tijd om ons juridisch voor te bereiden op de opkomende

Veiligheidskleding voor werk op de weg.

NARCIS (Netherlands)

1968-01-01

This report contains a problem-analysis about safety clothes for workers on the road. Some of the results are: (1) The best colour if fluorescing orange. (2) The material must be transporting warmth and moisture. The material which are available today, are not satisfactory.

Hiv-bestrijding begint met GIS-werk

NARCIS (Netherlands)

Op de Coul, E. L. M.; Joore, I. K.; van sighem, A.; Bom, B. C. J.; Hillebregt, M.; Prins, J. M.; Geerlings, S. E.; van Bergen, J. E. A. M.

2017-01-01

To map regions of the Netherlands with high HIV prevalence for surveillance and prevention purposes. Information on numbers of HIV patients receiving clinical care on 31 December 2014 per postcode region was requested from the HIV monitoring foundation (SHM). These details were related to data from

Unverrichteter Sache

Directory of Open Access Journals (Sweden)

Jani Kirov

2007-01-01

Full Text Available Rezensiertes Werk: Adriaan Lanni, Law and Justice in the Courts of Classical Athens, Cambridge: Cambridge University Press 2006, 210 S., ISBN-13 978-0-521-85759-8; ISBN-10 0-521-85759-7

Schattenboxen

Directory of Open Access Journals (Sweden)

Johannes Berchtold

2011-01-01

Full Text Available Rezensiertes Werk: Turan Kayaoğlu, Legal Imperialism. Sovereignty and Extraterritoriality in Japan, the Ottoman Empire, and China, New York: Cambridge University Press 2010, VIII, 237 p., ISBN 978-0-521-76591-6

Keim, Karl-Dieter, Das Fenster zum Raum : Traktat über die Erforschung sozialräumlicher Transformation / [rezensiert von] Helmut Klüter

OpenAIRE

Klüter, Helmut

2009-01-01

Rezensiertes Werk: Keim, Karl-Dieter: Das Fenster zum Raum : Traktat über die Erforschung sozialräumlicher Transformation / Karl-Dieter Keim. - Opladen : Leske + Budrich, 2003. - 171 S. : graph. Darst. - (Lehrtexte : Sozialwissenschaften) ISBN 3-8100-4050-9

Het Vietnam van Viet Thanh Nguyen [Bespreking van: V.T. Nguyen The sympathizer; V.T. Nguyen Nothing ever dies: Vietnam and the memory of war

NARCIS (Netherlands)

Kleinen, J.

2016-01-01

Over geen enkele Amerikaanse oorlog en de gevolgen daarvan zijn meer boeken geschreven dan over de Vietnamoorlog. En toch zijn we er nog lang niet over uitgeschreven. Terecht, getuige het verrassende werk van Viet Thanh Nguyen.

Laser-based direct-write techniques for cell printing

Energy Technology Data Exchange (ETDEWEB)

Schiele, Nathan R; Corr, David T [Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY (United States); Huang Yong [Department of Mechanical Engineering, Clemson University, Clemson, SC (United States); Raof, Nurazhani Abdul; Xie Yubing [College of Nanoscale Science and Engineering, University at Albany, SUNY, Albany, NY (United States); Chrisey, Douglas B, E-mail: schien@rpi.ed, E-mail: chrisd@rpi.ed [Material Science and Engineering Department, Rensselaer Polytechnic Institute, Troy, NY (United States)

2010-09-15

Fabrication of cellular constructs with spatial control of cell location ({+-}5 {mu}m) is essential to the advancement of a wide range of applications including tissue engineering, stem cell and cancer research. Precise cell placement, especially of multiple cell types in co- or multi-cultures and in three dimensions, can enable research possibilities otherwise impossible, such as the cell-by-cell assembly of complex cellular constructs. Laser-based direct writing, a printing technique first utilized in electronics applications, has been adapted to transfer living cells and other biological materials (e.g., enzymes, proteins and bioceramics). Many different cell types have been printed using laser-based direct writing, and this technique offers significant improvements when compared to conventional cell patterning techniques. The predominance of work to date has not been in application of the technique, but rather focused on demonstrating the ability of direct writing to pattern living cells, in a spatially precise manner, while maintaining cellular viability. This paper reviews laser-based additive direct-write techniques for cell printing, and the various cell types successfully laser direct-written that have applications in tissue engineering, stem cell and cancer research are highlighted. A particular focus is paid to process dynamics modeling and process-induced cell injury during laser-based cell direct writing. (topical review)

Laser-based direct-write techniques for cell printing

International Nuclear Information System (INIS)

Schiele, Nathan R; Corr, David T; Huang Yong; Raof, Nurazhani Abdul; Xie Yubing; Chrisey, Douglas B

2010-01-01

Fabrication of cellular constructs with spatial control of cell location (±5 μm) is essential to the advancement of a wide range of applications including tissue engineering, stem cell and cancer research. Precise cell placement, especially of multiple cell types in co- or multi-cultures and in three dimensions, can enable research possibilities otherwise impossible, such as the cell-by-cell assembly of complex cellular constructs. Laser-based direct writing, a printing technique first utilized in electronics applications, has been adapted to transfer living cells and other biological materials (e.g., enzymes, proteins and bioceramics). Many different cell types have been printed using laser-based direct writing, and this technique offers significant improvements when compared to conventional cell patterning techniques. The predominance of work to date has not been in application of the technique, but rather focused on demonstrating the ability of direct writing to pattern living cells, in a spatially precise manner, while maintaining cellular viability. This paper reviews laser-based additive direct-write techniques for cell printing, and the various cell types successfully laser direct-written that have applications in tissue engineering, stem cell and cancer research are highlighted. A particular focus is paid to process dynamics modeling and process-induced cell injury during laser-based cell direct writing. (topical review)

Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors.

Science.gov (United States)

Bhutada, Nilesh S; Rollins, Brent L

2015-01-01

Direct-to-consumer (DTC) advertising is still a controversial topic for pharmaceutical manufacturers' and researchers, and while numerous studies have examined the DTC phenomenon, little research has examined the effect of gender, particularly gender of the endorser and consumer. The objective of this research was to assess the impact of the endorser (celebrity vs. expert vs. non-celebrity) and gender - both gender of the endorser and gender of the consumer - on consumers' attitudes and behaviors in response to a print disease-specific direct-to-consumer advertisement. Using Qualtrics consumer panel, data were obtained for 514 US adults (age 18 years and above) who demonstrated at least minimal symptoms of depression and need for monitoring based on the Patient Health Questionnaire (PHQ) score. Data were analyzed using a 3 (Endorser Type: Celebrity/Expert/Non-Celebrity) × 2 (Endorser Gender: Male/Female) × 2 (Consumer Gender: Male/Female) full factorial between subjects multivariate analysis of variance (MANOVA) and necessary univariate analysis. Only the type of the endorser (celebrity vs. expert vs. non-celebrity) used in the ad had a significant main effect on the dependent variables. Further univariate analyses revealed that, of the several dependent variables, endorser type had a significant influence only on attitude towards the ad, attention paid to the ad, and endorser credibility, with gender being non-significant in all cases. Expert endorser generated significantly more favorable levels of attitude towards the ad, and endorser credibility compared to the non-celebrity endorser. Celebrity endorser attracted more consumer attention towards the ad and generated favorable endorser credibility perceptions compared to the non-celebrity endorser. However, celebrity and expert endorsers did not significantly differ from each other on the abovementioned ad effectiveness variables. Lastly, endorser gender and consumer gender did not have a significant influence

Waarom volwassenen met ADHD vaak te laat komen op afspraken – is het een beperking in de tijdwaarneming of het geheugen?

NARCIS (Netherlands)

Mette, Christian; Zielke, Annika; Groen, Yvonne

Volwassenen met aandachtstekortstoornis met hyperactiviteit (ADHD) hebben vaak moeite met tijdmanagement en het nakomen van afspraken. Een belangrijke functie voor tijdmanagement is tijdwaarneming, die weer samenhangt met de werking van het kortetermijn- en het werkgeheugen. De onderliggende

Absorption of formaldehyde in water

NARCIS (Netherlands)

Winkelman, Jozef Gerhardus Maria

2003-01-01

Deze dissertatie beschrijft theoretisch en experimenteel werk aan de absorptie van formaldehyde in water. Met resultaten hiervan zijn chemisch-technische modellen ontwikkeld voor de beschrijving en optimalisatie van industriële formaldehydeabsorbeurs. Deze samenvatting geeft eerst algemene

Digitalis en atriumfibrilleren anno 1985

NARCIS (Netherlands)

Meijler, F.L.; Tweel, I. van der

1985-01-01

In dit artikel worden enkele fundamentele aspecten van atriumfibrilleren en de rol van het atrioventriculaire geleidingssysteem daarbij besproken die ook van belang kunnen zijn voor de eerstelijnsgezondheidszorg, waarbij tevens aandacht wordt besteed aan de werking van digitalis.

Orienterend onderzoek naar de kwaliteit van champignonconserven

NARCIS (Netherlands)

Worp, van de H.H.M.; Herstel, H.

1981-01-01

Oriënterend onderzoek naar de kwaliteit van champignonconserven in verband met het in werking treden, per 1 januari 1982, van Verordening PGF 1981 Verduurzaamde Groenten. Vijf monsters champignonconserven werden onderzocht op etikettering, bijzondere kwaliteitsvoorschriften, de toevoegingen

en daar ook drie vertaalde gedigte van Giorgos Seferis opgeneem is ...

African Journals Online (AJOL)

waaraan Kavafis sy roem veral te danke het) nie, maar ook uit werk met 'n meer. histories beskoulike strekking (die tweede groot tema by Kavafis), asook gedigte wat nie tot die heel bekendstes van Kavafis behoort nie.

Temporal correlation coefficient for directed networks.

Science.gov (United States)

Büttner, Kathrin; Salau, Jennifer; Krieter, Joachim

2016-01-01

Previous studies dealing with network theory focused mainly on the static aggregation of edges over specific time window lengths. Thus, most of the dynamic information gets lost. To assess the quality of such a static aggregation the temporal correlation coefficient can be calculated. It measures the overall possibility for an edge to persist between two consecutive snapshots. Up to now, this measure is only defined for undirected networks. Therefore, we introduce the adaption of the temporal correlation coefficient to directed networks. This new methodology enables the distinction between ingoing and outgoing edges. Besides a small example network presenting the single calculation steps, we also calculated the proposed measurements for a real pig trade network to emphasize the importance of considering the edge direction. The farm types at the beginning of the pork supply chain showed clearly higher values for the outgoing temporal correlation coefficient compared to the farm types at the end of the pork supply chain. These farm types showed higher values for the ingoing temporal correlation coefficient. The temporal correlation coefficient is a valuable tool to understand the structural dynamics of these systems, as it assesses the consistency of the edge configuration. The adaption of this measure for directed networks may help to preserve meaningful additional information about the investigated network that might get lost if the edge directions are ignored.

Regional impacts of abolishing direct payments

DEFF Research Database (Denmark)

Uthes, Sandra; Priorr, Annette; Zander, Peter

2011-01-01

The direct payment system of the Common Agricultural Policy (CAP) provides income transfers to European farmers. Recently, several countries including England and Sweden have advocated the elimination of direct payments after 2013. The extent to which an elimination of direct payments would affect...... with different production orientations and land management types was modeled under the presence and absence of direct payments using a combination of agent-based and bio-economic modeling. We found that the initial characteristics of the regions, such as the historical farm structure and regional site conditions...

A Comparative Characterization of the HPA-MCM-48 Type Catalysts Produced by the Direct Hydrothermal and Room Temperature Synthesis Methods

International Nuclear Information System (INIS)

Gucbilmez, Y.; Calis, I.; Yargic, A. S.

2012-01-01

MCM-48 type support materials synthesized by the direct hydrothermal synthesis (HTS) and room temperature synthesis (RTS) methods were incorporated with tungstophosphoric acid (TPA) in the range of 10-40 wt% by using a wet impregnation technique in methanol solutions. Resulting HPA-MCM-48 catalysts were characterized by the XRD, Nitrogen Physisorption, SEM, TEM, EDS, and FT-IR methods in order to determine the effects of different initial synthesis conditions on the catalyst properties. RTS samples were found to have better crystalline structures, higher BET surface areas, and higher BJH pore volumes than HTS samples. They also had slightly higher TPA incorporation, except for the 40 wt% samples, as evidenced by the EDS results. Keggin ion structure was preserved, for both methods, even at the highest acid loading of 40 wt%. It was concluded that the simpler and more economical RTS method was more successful than the HTS method for hetero poly acid incorporation into MCM-48 type materials

Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes

DEFF Research Database (Denmark)

Sondergaard, B C; Wulf, H; Henriksen, K

2006-01-01

OBJECTIVE: Calcitonin was recently reported to counter progression of cartilage degradation in an experimental model of osteoarthritis, and the effects were primarily suggested to be mediated by inhibition of subchondral bone resorption. We investigated direct effects of calcitonin on chondrocytes...... by assessing expression of the receptor and pharmacological effects on collagen type II degradation under ex vivo and in vivo conditions. METHODS: Localization of the calcitonin receptor on articular chondrocytes was investigated by immunohistochemistry, and the expression by reverse transcriptase polymerase.......0001-1 microM]. In vivo, cartilage degradation was investigated in ovariectomized (OVX) rats administered with oral calcitonin [2 mg/kg calcitonin] for 9 weeks. RESULTS: The calcitonin receptor was identified in articular chondrocytes by immunohistochemistry and RT-PCR. Calcitonin concentration...

Exercise for type 1 diabetes mellitus management: General considerations and new directions.

Science.gov (United States)

Farinha, Juliano Boufleur; Krause, Maurício; Rodrigues-Krause, Josianne; Reischak-Oliveira, Alvaro

2017-07-01

Type 1 diabetes mellitus (T1DM) is characterized by the loss of insulin secreting cells due to a directed autoimmune process, which is linked to oxidative stress and inflammation. Exercise training is known to induce several benefits by reducing inflammation and improving antioxidant defenses. In this context, exercise training may be considered as an efficient and relatively inexpensive non-pharmacological tool for diabetes treatment, added to the usual insulin administration. Unfortunately, most people with T1DM do not reach the recommended levels of physical activity due to concerns with hypoglycemic episodes. Recent data have demonstrated that exercise sessions composed by strength exercises or high-intensity interval exercise reduce the risk of hypoglycemia during and after the physical effort, when compared with continuous aerobic exercise in insulin-dependent patients. However, no studies have tested the chronic effects of this combination of protocols on health-related markers yet. Herein, we suggest a combination of hypertrophic strength exercises (3 sets at 8-RM) with a high-intensity interval protocol (10×60-s bouts at ∼90% HR max interspersed with 60s recovery) in the same exercise session, three times per week, for T1DM patients free of micro and macrovascular complications. Our hypothesis is that this training protocol may minimize the exercise-associated rapid drop of glucose levels in T1DM, due to glucoregulatory hormones and transient reduction of insulin-mediated glucose uptake. This training is also likely to cover long-term glycaemic, bioenergetic, neuromuscular and cardiorespiratory adaptations, implicating in improved health and decreased risk of micro and macro complications. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evaluation of Impact of Coagulant Type on Operation Parameters in Direct Filtration

Directory of Open Access Journals (Sweden)

Ali Torabian

2007-06-01

Full Text Available Numerous advantages have been reported on PAC (poly aluminum chloride used as a coagulant over other coagulants such as alum and ferric chloride used in conventional water treatment process with medium and high turbidity levels. These include lower amounts of PACL required specially in removing turbidity, larger floc grain formation, reduced floc sedimentation time, lower sludge production, and relaxation of the need for pH adjustment by lime, among others. The present study aims to evaluate the effects of different coagulants such as ferric chloride and PACL on direct filtration and to identify the most effective material based on both turbidity and particle removal efficiencies. A perfectly experimental pilot system, including raw water preparation, coagulation, flocculation, distribution measurement, and filtration units, was designed and used. Raw water turbidity level in the experimental pilot was below 10 NTU. The effects of various parameters such as coagulant type, filtration rate, and coagulant dosage on the performance of the filter were investigated. The results obtained from several filtration cycles under different conditions indicated that average effluent turbidity level, effluent particle numbers, effluent turbidity variation graph, and effluent particle graph were lower throughout the filtration cycle when PACL was used compared to when ferric chloride was used as the coagulant. Increasing filtration rate led to increased turbidity and particle number. Addition of 2 mg/l of PACL (poor coagulation and flocculation scenario was compared with addition of 5 mg/l of ferric chloride (strong coagulation and flocculation scenario. The results indicated that higher average values of turbidity removal but lower turbidity and particle removal efficiencies obtained in the case of the poor coagulation and flocculation scenario.

Muentz-Szasz type approximation in direct products of spaces

Energy Technology Data Exchange (ETDEWEB)

Sedletskii, A M [M.V. Lomonosov Moscow State University, Moscow (Russian Federation)

2006-10-31

We consider the problem of completeness of the system of exponentials exp{l_brace}-{lambda}{sub n}t{r_brace}, Re {lambda}{sub n}>0, in direct products E=E{sub 1} x E{sub 2} of the spaces E{sub 1}=E{sub 1}(0,1) and E{sub 2}=E{sub 2}(1,{infinity}) of functions defined on (0,1) and (1,{infinity}), respectively. We describe rather broad classes of spaces E{sub 1} and E{sub 2} such that the well-known condition of Szasz is necessary for the completeness of the above system in E and sufficient for this completeness.

Een hoge werkdruk sluipt er in

NARCIS (Netherlands)

Hulst, van der M.

2005-01-01

De werkdruk op het melkveebedrijf neemt toe. Boeren raken aan de grenzen van hun kunnen, waardoor de lol in het werk afneemt. Bespreking van de arbeidsinzet op het bedrijf in een studiegroep leidt tot efficiënter werken

Gewenst beleid tegen ongewenst gedrag : onveiligheid binnen de organisatie kan leiden tot ziekteverzuim

NARCIS (Netherlands)

Dalen, E.J. van; Nuyens, M.

2005-01-01

Indimidatie en agressie en geweld op het werk kunnen leiden tot gevoelens van onveiligheid en ziekteverzuim. Bepalingen in de Arbowet hebben onvoldoende effect op beleidsvorming ter voorkoming van ongewenste omgangsvormen. Goede praktijkvoorbeelden van beleid tegen ongewenst gedrag kunnen

kant geveg het) aan sv lesers vaor Ie. Die deel sol" aFgesluit word ...

African Journals Online (AJOL)

Uggla se verslag oor die herdenkingsbveenkomste von die slog von. MogersFontein (Stockholm, 1926). Op p. ix von die publikasie verskvn 'n bibliograFie von bestaande werke in AFrikoons, Engels en. Nederlands wat oandog oan die lotgevalle ...

Medezeggenschap bij DSM: Limburg 1946-2011

NARCIS (Netherlands)

Buitelaar, W.

2011-01-01

"Doing Something Meaningful", zo kenmerkte DSM-bestuursvoorzitter Feike Sijbesma de activiteiten van het concern (NRC, 23 februari 2011). Dat geldt in onderstaande terugblik over de periode 1946-2011 evenzeer voor het werk van de medezeggenschappers van DSM Limburg.

Inverted dipole feature in directional detection of exothermic dark matter

International Nuclear Information System (INIS)

Bozorgnia, Nassim; Gelmini, Graciela B.; Gondolo, Paolo

2017-01-01

Directional dark matter detection attempts to measure the direction of motion of nuclei recoiling after having interacted with dark matter particles in the halo of our Galaxy. Due to Earth's motion with respect to the Galaxy, the dark matter flux is concentrated around a preferential direction. An anisotropy in the recoil direction rate is expected as an unmistakable signature of dark matter. The average nuclear recoil direction is expected to coincide with the average direction of dark matter particles arriving to Earth. Here we point out that for a particular type of dark matter, inelastic exothermic dark matter, the mean recoil direction as well as a secondary feature, a ring of maximum recoil rate around the mean recoil direction, could instead be opposite to the average dark matter arrival direction. Thus, the detection of an average nuclear recoil direction opposite to the usually expected direction would constitute a spectacular experimental confirmation of this type of dark matter.

Neue Klassik-CDs

Index Scriptorium Estoniae

2001-01-01

Firma Antes plaatide seas "Eesti portreed. Werke für Flöte und Gitarre", "Kangro. Klavierkonzert Nr.2"; Deutsche Grammophon'i plaat "Steinberg dir, N. Järvi"; Globe plaat "Tanejev. The Twelve Choruses op. 27", dir. T. Kaljuste

Een empirisch onderzoek naar de rol van de openbare apotheker in de geneesmiddelenvoorziening

NARCIS (Netherlands)

A. Mantel; B. Wierenga (Berend)

1988-01-01

textabstractIn het kader van het in opdracht van het Ministerie van Welzijn, Volksgezondheid en Cultuur verrichte wetenschappelijk onderzoek 'De Nederlandse geneesmiddelenmarkt in observatie' is door een projectgroep een studie verricht naar structuur en werking van de Nederlandse extramurale

Inelastic processes in atomic collisions involving ground state and laser-prepared atoms

NARCIS (Netherlands)

Planje, Willem Gilles

1999-01-01

In dit proefschrift worden experimenten beschreven waarbij ionen of atomen met een bepaalde snelheid op een ensemble van doelwitatomen worden gericht. Wanneer twee deeltjes elkaar voldoende genaderd hebben, vindt er wissel- werking plaats waarbij allerlei processen kunnen optreden. Deze

Official announcement of the directive on protection of nuclear power plant equipped with LWR-type reactors from human intrusion or other interference by third parties. Announcement of BMU (German Federal Ministry Environment), of 6 Dec. 1995 - RS I 3 13151 - 6/14

International Nuclear Information System (INIS)

1996-01-01

An operating permit for a nuclear power plant is to be granted only if the applicant and facility operator presents evidence guaranteeing the legally required physical protection and other security measures for protection from human instrusion and other type of interference. As a basis for review and licensing, the competent authorities in 1987 have issued a directive specifying the requirements to be met for physical protection of nuclear power plant equipped with PWR-type reactors, and in 1994 followed a second, analogous directive relating to nuclear power plant with BWR-type reactors. The directive now announced for physical protection of nuclear power plant equipped with LWR-type reactors combines and replaces the two former ones, and from the date of the announcement is the only applicable directive. The text of the directive is not reproduced for reasons of secrecy protection. (orig./CB) [de

Kansrijk ; verbeteren van Leerlingprestaties door schoolontwikkeling

NARCIS (Netherlands)

Houtveen, A.A.M.; Kuijpers, J.M.; Mijs, T.J.E.

2004-01-01

Zes onderwijskansenscholen zijn onder begeleiding van het Christelijk Pedagogische Studiecentrum (CPS) hard aan het werk om de kwaliteit van hun onderwijs te verbeteren. Er zijn vier hoofdoorzaken aan te wijzen voor het achterblijven van de prestaties op onderwijskansenscholen. Deze zijn: een

Case note: EHRM (Grand Chamber) (zaaknr. 16354/06, LJN BX9103: Mouvement Raëlien Suisse/Zwitserland: verbod verspreiding posters is niet in strijd met de vrijheid van meningsuiting)

NARCIS (Netherlands)

Dommering, E.J.

2014-01-01

Mensenrechten. Vrijheid van meningsuiting. Weigering van vergunning voor het ophangen van posters van organisatie die contact met buitenaardse wezens nastreeft. Uiting is eerder commercieel dan politiek van aard wegens ‘bekerende’ werking. Vanwege vermelding website moet ook inhoud daarvan worden

Over granulosaceltumoren en hun hormonalen invloed op uterus en tuba

NARCIS (Netherlands)

Kleijn, Christiaan Hendrik Frans

1937-01-01

In dit proefschrift is nagegaan de histologie van de granulosacelrumoren en hun hormonale werking. De granulosaceltumoren danken hun naam aan de overeenkomst in vorm en structuur tusschen hun cellen en granulosacellen. Deze overeenkomst gaat zeer ver: aile differentiatiestadia, die de granulosa

Kui suur on maailmakirjandus? / Cornelius Hasselblatt

Index Scriptorium Estoniae

Hasselblatt, Cornelius, 1960-

2015-01-01

Arvustus: Aija Sakova-Merivee. Ausgraben und Erinnern. Denkbilder des Erinnerns und der moralischen Zeugenschaft im Werk von Ene Mihkelson und Christa Wolf. Tartu : University of Tartu Press, c2014. (Dissertationes litterarum et contemplationis comparativae Universitatis Tartuensis, 1406-913X ; 13)

Waar blijven de nieuwe Pythagorassen en Archimedessen? : met potlood, papier, liniaal, passer èn gummetje rechtgeleidingen construeren

NARCIS (Netherlands)

Dijksman, E.A.

1994-01-01

Rekenmachines hebben het werktuigbouwkundig onderwijs zeer nadelig beinvloed. De digitale (algebraische) werking ervan heeft de meetkunde vèr onderuit gehaald. Werktuigbouwkundige studenten weten bijna niets meer af van de eigenschappen van een cirkel, cirkelbundels met een machtlijn, of van Iijnen

Experimental improvisation practise and notation. Addenda 2000-

DEFF Research Database (Denmark)

Bergstrøm-Nielsen, Carl

Addenda to Experimental improvisation practise and notation (please see this title for more information!) Stichwörter: experimentelle Musik, offenes Werk, grafische Notation, musikalische Notation, musikalische Aufführungspraxis, freie Improvisation, Musikpädagogik, Geschichte der Musik, Musikäst...

Nieuws uit het westen : meerouderschap en draagmoederschap in British Columbia

NARCIS (Netherlands)

Vonk, M.J.

2016-01-01

In 2013 is in de Canadese provincie British Columbia nieuwe familierechtwetgeving in werking getreden: de Family Law Act, met daarin een regeling voor draagmoederschap, meerouderschap en meeroudergezag. Gezien de discussie in Nederland over deze onderwerpen en de instelling van de Staatscommissie

Spiegelkunde

Directory of Open Access Journals (Sweden)

Pia Letto-Vanamo

2005-01-01

Full Text Available Rezensiertes Werk:Jørn Øyrehagen Sunde, Speculum legale – rettsspegelen. Ein introduksjon til den norske rettskulturen si historie i eit europeisk perspektiv, Bergen: Fagbokforlaget Vigmostad & Bjørke 2005, 409 S., ISBN 82-450-0090-6

Direct social perception and dual process theories of mindreading.

Science.gov (United States)

Herschbach, Mitchell

2015-11-01

The direct social perception (DSP) thesis claims that we can directly perceive some mental states of other people. The direct perception of mental states has been formulated phenomenologically and psychologically, and typically restricted to the mental state types of intentions and emotions. I will compare DSP to another account of mindreading: dual process accounts that posit a fast, automatic "Type 1" form of mindreading and a slow, effortful "Type 2" form. I will here analyze whether dual process accounts' Type 1 mindreading serves as a rival to DSP or whether some Type 1 mindreading can be perceptual. I will focus on Apperly and Butterfill's dual process account of mindreading epistemic states such as perception, knowledge, and belief. This account posits a minimal form of Type 1 mindreading of belief-like states called registrations. I will argue that general dual process theories fit well with a modular view of perception that is considered a kind of Type 1 process. I will show that this modular view of perception challenges and has significant advantages over DSP's phenomenological and psychological theses. Finally, I will argue that if such a modular view of perception is accepted, there is significant reason for thinking Type 1 mindreading of belief-like states is perceptual in nature. This would mean extending the scope of DSP to at least one type of epistemic state. Copyright © 2015 Elsevier Inc. All rights reserved.

ABOUT DIRECT SALES IN THE WORLD, EUROPE AND ROMANIA

Directory of Open Access Journals (Sweden)

CLAUDIA ISAC

2011-01-01

Full Text Available Direct sale represents a modern product distribution system directly to consumers, generally, directly to their homes, to their workplace or other places, beside retail shops. The best known type of direct sale, the Network Marketing or Multilevel Marketing implies the existence of a network of distributors which earn income from selling on commission, to which they add the trade markup. This paper is based upon the analysis of these types of sales starting with the study of specialized literature especially by foreign authors, mainly Americans, with the analysis of statistical data presented by several organizations such as SELDIA (The European Direct Selling Association, MLM International Romania, ACVD (Association of Direct Selling Companies in Romania, as well as the legal regulations within this field. In conclusion, the paper presents an interesting comparison of the sales and structure volume between the Europe and Romania.

Electrostatic direct energy converter performance and cost scaling laws

International Nuclear Information System (INIS)

Hoffman, M.A.

1977-08-01

This study is concerned with electrostatic type direct energy converters for direct recovery of a large fraction of the plasma ion energy from fusion reactors. Simplified equations are presented for each of the important loss mechanisms in both single-stage direct converters and multistage ''Venetian Blind'' type direct converters. These equations can be used to estimate the efficiency and electric power output of the direct converter subsystem. Scaling relations for the cost of each major component in the direct converter subsystem are also given; these include the vacuum tank, direct converter modules, the DC power conditioning equipment, cryogenic vacuum pumping system and the thermal bottoming plant. The performance and cost scaling laws have been developed primarily for use in overall fusion power plant systems codes. However, to illustrate their utility, cost-effectiveness studies of two specific reference direct converter designs are presented in terms of the specific capital costs (i.e., the capital cost per unit electric power produced) for the Direct Converter Subsystem alone. Some examples of design improvements which can significantly reduce the specific capital costs of the Direct Converter Subsystem are also given

Process evaluation of a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus.

Science.gov (United States)

Odgers-Jewell, Kate; Isenring, Elisabeth; Thomas, Rae; Reidlinger, Dianne P

2017-07-01

The present study developed and evaluated a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus. Two frameworks, the Medical Research Council (MRC) framework for developing and evaluating complex interventions and the RE-AIM framework were followed. Data to develop the intervention were sourced from scoping of the literature and formative evaluation. Program evaluation comprised analysis of primary recruitment of participants through general practitioners, baseline and end-point measures of anthropometry, four validated questionnaires, contemporaneous facilitator notes and telephone interviews with participants. A total of 16 participants enrolled in the intervention. Post-intervention results were obtained from 13 participants, with an estimated mean change from baseline in weight of -0.72 kg (95%CI -1.44 to -0.01), body mass index of -0.25 kg/m 2 (95%CI -0.49 to -0.01) and waist circumference of -1.04 cm (95%CI -4.52 to 2.44). The group education program was acceptable to participants. The results suggest that recruitment through general practitioners is ineffective, and alternative recruitment strategies are required. This patient-centred, patient-directed, group-based intervention for the management of type 2 diabetes mellitus was both feasible and acceptable to patients. Health professionals should consider the combined use of the MRC and RE-AIM frameworks in the development of interventions to ensure a rigorous design process and to enable the evaluation of all phases of the intervention, which will facilitate translation to other settings. Further research with a larger sample trialling additional recruitment strategies, evaluating further measures of effectiveness and utilising lengthier follow-up periods is required. © 2016 Dietitians Association of Australia.

Ambtscriminaliteit aangegeven? : Een onderzoek naar het opvolgen van en kennis over de wettelijke verplichting tot aangifte van artikel 162 Sv misdrijven

NARCIS (Netherlands)

Vries Robbé, E. de; Cornelissens, A.; Ferwerda, H.

2008-01-01

Dit is een onderzoek naar de werking van de aangifteplicht bij ambtscriminaliteit (art 162 Sv). Het gaat dan bijvoorbeeld om het aannemen van steekpenningen en misdrijven waarbij ambtenaren een bijzondere ambtsplicht schenden. De aangifteplicht raakt de klokkenluidersregeling en maakt onderdeel uit

Stapelbouw

NARCIS (Netherlands)

Vissers, M.M.J.; Vlaar, G.J.; Hofkes, xx; Brinksma, xx; Zimmermann, xx; Van Tol, xx; Flapper, xx; Bonebakker, xx

2006-01-01

Men zou kunnen zeggen dat de benaming van een bouwmethode voortkomt uit de verwerkingsvorm van de bouwmaterialen en producten die worden gebruikt voor de hoofddraagstructuur (casco) en vooral daarvan het opgaande werk. Met andere woorden: de wijze waarop de productiemiddelen (materiaal, materieel en

X-ray and neutron diffraction studies of some liquid alkali metals and alloys

NARCIS (Netherlands)

Huijben, Martinus Johannes

1978-01-01

Het in dit proefschrift beschreven onderzoek is een logische consequentie van de probleemstelling die ten grondslag ligt aan het werk binnen de werkgroep "Vloeibare Metalen"van het laboratorium voor Vaste Stof Fysica, nl. de interpretatie van de eigenschappen van eenvoudige vloeibare metalen en

Tuumafüüsik möllab BMW-s nagu jaksab / Toomas Pärna

Index Scriptorium Estoniae

Pärna, Toomas, 1966-

2004-01-01

Bayerische Motoren Werke (BMW) brändi maine kujundamisest, BMW juhi Helmut Panke poolt ärgitatud pidevast tootearendusest ettevõttes ning kiire arenguga seotud võimalikest riskidest. Lisa: BMW-de müük Eestis Vt. samas: BMW luksuskupee müüdud

Social inclusion in diverse work settings

NARCIS (Netherlands)

Jansen, Wiebren

2015-01-01

Het ervaren van sociale inclusie op het werk is essentieel voor het welbevinden en presteren van werknemers. Echter, terwijl inclusie relatief gemakkelijk te bewerkstelligen is wanneer collega’s demografisch gezien op elkaar lijken, is dit moeilijker wanneer collega's sterk van elkaar verschillen.

Optimization of ultrasonic extraction of mycelial polysaccharides ...

African Journals Online (AJOL)

ajl yemi

2011-11-28

Nov 28, 2011 ... air dryer and ground into powder by a muller (A11 basic, ZKA-. WERKE ..... of regression equation were taken and made to be zero. Calculating the .... ia of Dietary Supplements New York: Marcel Dekker. pp. 665-679. Hou XJ ...

Deutsche Fremdwortlexikografie zwischen 1800 und 2007

DEFF Research Database (Denmark)

Heier, Anke

daran, dass in ihnen ein Wortschatzbereich erfasst, beschrieben, kommentiert, zum Teil auch diskutiert wird, der in der Öffentlichkeit bis heute besondere Aufmerksamkeit erfährt. Bisher fokussierten wissenschaftliche Analysen jedoch vor allem auf ältere und puristische Werke. Diese Untersuchung nimmt...

'Je moeder leert je wie je vijanden zijn'

NARCIS (Netherlands)

Makkink, C.; Parmentier, H.K.

2014-01-01

Via de voeding van ouderdieren kan de werking van het immuunsysteem van de nakomelingen worden beïnvloed. Het is een uitdaging om interventies te vinden die het immuunsysteem van landbouwhuisdieren optimaliseren, zo luidde de conclusie tijdens de Feed4Foodure-themamiddag.

De bezielde zakelijkheid van M. Revis : Over het oeuvre van een vergeten auteur

NARCIS (Netherlands)

Anten, J.H.M.

1990-01-01

Feiten, cijfers en beschrijvingen van manoeuvres in de handels- en geldwereld spelen een belangrijke rol in het werk van M. Revis. Zijn fascinatie voor het maatschappelijkeconomisch leven enerzijds, en zijn protest tegen sociale misstanden anderzijds, maken hem tot een opmerkelijk auteur. In dit

Sexual orientation and the workplace experience

NARCIS (Netherlands)

Lisette Kuyper

2013-01-01

Original title: Seksuele oriëntatie en werk Large-scale studies are regularly held in the Netherlands to monitor the employment situation and work experience of employees. However, some groups of employees receive insufficient attention in these studies. The Netherlands Institute for Social

South African Journal of Child Health - Vol 4, No 4 (2010)

African Journals Online (AJOL)

Diffuse bony involvement in disseminated BCG disease in a patient with possible severe combined immune deficiency (SCID) · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. N Khan, I van de Werke, F Ismail, 116-118 ...

Equal Opportunities and Ethnic Inequality in European Labour Markets : Discrimination, Gender and Policies of Diversity

NARCIS (Netherlands)

2009-01-01

De noodzaak om de arbeidsmarkt mechanismen in postindustriële westerse samenlevingen te analyseren is urgent. Ondanks wetten en beleidsmaatregelen die op Europees, nationaal en lokaal niveau worden ontwikkeld, lijdt het zoeken van werk door immigranten en etnische minderheden nog steeds onder

Rollencombinaties

NARCIS (Netherlands)

A.C. Liefbroer (Aart); P.A. Dykstra (Pearl)

2001-01-01

textabstractMannen verdienen het inkomen voor het gezin, vrouwen doen het huishoudelijk werk en verzorgen de kinderen. Dit is het beeld dat bestaat van het standaardgezin. Maar zo traditioneel-eenzijdig hebben de Nederlandse huishoudens de taken niet verdeeld: het standaardgezin past slechts bij

Locus: mede-ontwikkelaar van inclusieve arbeidsorganisaties

NARCIS (Netherlands)

Beukema, Leni; de Lange, Annet; Wielenga-Meijer, Etty; Duijker, Theo; Hanstede, Bram

2018-01-01

in deze bijdrage wordt Locus beschreven, een netwerk waarin publieke partijen en grote, landelijk opererende bedrijven samenwerken om mensen met een afstand tot de arbeidsmarkt duurzaam aan het werk te helpen. Het hoofdstuk start met de ontstaansgeschiedenis en benadering van Locus. Vervolgens wordt

The penicillin-binding protein 4 of Escherichia coli : primary structure, biochemical and genetic studies

NARCIS (Netherlands)

Mottl, Harald

1992-01-01

De ß-lactam antibiotica ("de penicillines") zijn zowel in medisch als ecomisch opzicht de belangrijkste groep antibiotica: De werking van deze antibiotica berust op verstoring van de synthese van de bacteriele celwand. De doeleiwitten van deze antibiotica worden penicillin-binding proteins, kortweg

Type Ia Supernova Cosmology

Science.gov (United States)

Leibundgut, B.; Sullivan, M.

2018-03-01

The primary agent for Type Ia supernova cosmology is the uniformity of their appearance. We present the current status, achievements and uncertainties. The Hubble constant and the expansion history of the universe are key measurements provided by Type Ia supernovae. They were also instrumental in showing time dilation, which is a direct observational signature of expansion. Connections to explosion physics are made in the context of potential improvements of the quality of Type Ia supernovae as distance indicators. The coming years will see large efforts to use Type Ia supernovae to characterise dark energy.

A Randomized Controlled Trial Comparing the Letter Project Advance Directive to Traditional Advance Directive.

Science.gov (United States)

Periyakoil, Vyjeyanthi S; Neri, Eric; Kraemer, Helena

2017-09-01

Simpler alternatives to traditional advance directives that are easy to understand and available in multiple formats and can be initiated by patients and families will help facilitate advance care planning. The goal of this study was to compare the acceptability of the letter advance directive (LAD) to the traditional advance directive (TAD) of the state of California. A web-based, randomized controlled trial was conducted, in which the participants were randomized to one of two types of advance directives (ADs): the LAD (intervention) or the TAD (control). Primary outcomes were participant ratings of the ease, value, and their level of comfort in the AD document they completed. A total of 400 participants completed the study, with 216 randomized to the LAD and 184 to the TAD by a computerized algorithm. Overall, participants preferred the LAD to the TAD (success rate difference [SRD] = 0.46, 95th percentile confidence interval [CI]: 0.36-0.56, p advance directive to be a better alternative to the traditional advance directive form.

75 FR 66009 - Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia...

Science.gov (United States)

2010-10-27

... Company (Type Certificate Previously Held by Columbia Aircraft Manufacturing (Previously the Lancair... Company (Type Certificate Previously Held by Columbia Aircraft Manufacturing (Previously The Lancair...-15895. Applicability (c) This AD applies to the following Cessna Aircraft Company (type certificate...

Sarah Dellmann: Widerspenstige Körper. Körper, Kino, Sprache und Subversion in Tod Brownings FREAKS und Filmen mit Lon Chaney. Marburg: Schüren Verlag 2009.

Directory of Open Access Journals (Sweden)

Fabian Tietke

2010-11-01

Full Text Available Im vorliegenden Band werden Filme des in den 1920er und 1930er Jahren sehr erfolgreichen Regisseurs Tod Browning analysiert, insbesondere sein heute bekanntestes Werk Freaks. Mithilfe historischer Kontextualisierungen und eines filmwissenschaftlichen Instrumentariums untersucht Dellmann die These, dass sich in diesem Werk Spuren eines heute verloren gegangenen Körperverständnisses finden lassen – vor allem andere Repräsentationen von Behinderung und behinderten männlichen Körpern.The present anthology analyzes several movies of the director Tod Browning (who was very successful in the 1920s and 1930s, particularly the movie Freaks which, today, is his most well-known work. Using historical contextualizations and a Film Studies background, Dellmann explores the thesis that this work shows traces of an understanding of the body that today no longer exist, above all the representation of disabilities and disabled male bodies.

Multiparty Asynchronous Session Types

DEFF Research Database (Denmark)

Honda, Kohei; Yoshida, Nobuko; Carbone, Marco

2016-01-01

. This work extends the foregoing theories of binary session types to multiparty, asynchronous sessions, which often arise in practical communication-centered applications. Presented as a typed calculus for mobile processes, the theory introduces a new notion of types in which interactions involving multiple......Communication is a central elements in software development. As a potential typed foundation for structured communication-centered programming, session types have been studied over the past decade for a wide range of process calculi and programming languages, focusing on binary (two-party) sessions...... peers are directly abstracted as a global scenario. Global types retain the friendly type syntax of binary session types while specifying dependencies and capturing complex causal chains of multiparty asynchronous interactions. A global type plays the role of a shared agreement among communication peers...

Direct evidence of fiber type-dependent GLUT-4 expression in human skeletal muscle

DEFF Research Database (Denmark)

Gaster, M; Poulsen, P; Handberg, A

2000-01-01

GLUT-4 expression in individual fibers of human skeletal muscles in younger and older adults was studied. Furthermore, the dependency of insulin-stimulated glucose uptake on fiber type distribution was investigated. Fiber type distribution was determined in cryosections of muscle biopsies from 8...... of slow fibers in the young (r = -0.45, P > 0.25) or in the elderly (r = 0. 11, P > 0.75) subjects. In conclusion, in human skeletal muscle, GLUT-4 expression is fiber type dependent and decreases with age, particularly in fast muscle fibers....

What employers may learn from English higher education institutions: A fortigenic approach to occupational stress

Directory of Open Access Journals (Sweden)

M. Y. Tytherleigh

2003-10-01

Full Text Available Whilst there is no denying that levels of occupational stress in staff working in universities and colleges are increasing, academic staff, in particular, continue to maintain a level of satisfaction from their jobs. A stratified random sample of staff working in 14 higher education institutions in England was used. The results showed that, whilst commitment was lower and levels of occupational stress were significantly higher with regard to work relationships, control and resources and communication, compared to the normative data, staff reported significantly lower levels of stress relating to work-life balance, overload, and job dissatisfaction. Compared to normative data, participants reported significantly lower levels of physical ill-health and psychological outcomes of stress. The results support previous findings identifying a protective effect of job satisfaction against the negative consequences of workplace stress. Opsomming Terwyl dit nie ontken word dat die vlak van werkstres van personeel wat in universiteite en kolleges werk, verhoog nie, ervaar akademiese personeel steeds tevredenheid met hul werk. ’n Gestratifiseerde ewekansige steekproef van personeel wat by 14 hoër opvoedkundige instellings in Engeland werk, is geneem. Die resultate het aangetoon dat hoewel verbondenheid laer en werkstres beduidend hoër was ten opsigte van werksverhoudinge, kontrole en bronne en kommunikasie vergeleke met normatiewe data, personeel beduidend laer vlakke van stres ten opsigte van werklewe balans, oorlading en werkstevredenheid getoon het. Deelnemers het ook beduidend laer vlakke van fisieke ongesondheid en psigologiese uitkomstes van stres gerapporteer. Die resultate ondersteun vorige bevindings wat ’n beskermende effek van werkstevredenheid teen die negatiewe uitkomstes van stres identifiseer.

In vitro cultivation of Cryptosporidium parvum. A literature survey

NARCIS (Netherlands)

Schets FM; Leenen EJTM; MGB

1998-01-01

In vivo en in vitro modellen voor kweek van Cryptosporidium geven informatie over de infectiviteit van oocysten in ruw water en drinkwater en kunnen de identificatie van middelen met een anticryptosporidiele werking vereenvoudigen. In vivo modellen zijn echter duur, onpractisch en niet in elk

3D Printing verbindt Fontys Instituten : De basis voor een verdere samenwerking

NARCIS (Netherlands)

Drs. Ing. Ricardo Abdoel

2015-01-01

De wereld verandert in een razend tempo. Technologische ontwikkelingen hebben een grote impact op mens en maatschappij. Het verandert niet alleen onze manier van werken maar ook onze manier van leven. Steeds meer disciplines hanteren technologie als basis om in een professionele omgeving het werk

Carbohydrates : more than meets the eye

NARCIS (Netherlands)

Lopez-Bautista, Cesar

2012-01-01

Biofysica van koolhydraten op moleculair niveau Het proefschrift van César López Bautista onthult belangrijke aspecten van de biofysica van koolhydraten op moleculair niveau. Zijn werk laat zien hoe ‘state of the art’ moleculaire dynamica benaderingen diepere inzichten kunnen geven in het

How BMW Is Defusing the Demographic Time Bomb

NARCIS (Netherlands)

C.H. Loch (Christoph); F.J. Sting (Fabian); N. Bauer (Nikolaus); H. Mauermann (Helmut)

2010-01-01

textabstractThe article focuses on how the German car manufacturer, Bayerische Motoren Werke AG or BMW, is managing the effects of population aging on the industry. The redesign of BMW's factories to accommodate older workers and increase productivity is mentioned. Research on a pilot production

Insulin sensitivity : modulation by the gut-brain axis

NARCIS (Netherlands)

Heijboer, Annemieke Corine

2006-01-01

Er zijn steeds meer aanwijzingen dat neuropeptiden in de hypothalamus en maagdarmhormonen die hun werking hebben op de hypothalamus en betrokken zijn bij de regulatie van voedselinname, ook betrokken zouden kunnen zijn bij de regulatie van insuline gevoeligheid. Daarom hebben we eerst de effecten

Imidacloprid of niet? (interview met Sjef van der Steen)

NARCIS (Netherlands)

Kleis, R.; Steen, van der J.J.M.

2014-01-01

Is bijensterfte het werk van neonicotinoïden? Ja, zeggen en denken velen. Volgens hen zijn de neo’s rechtstreeks verantwoordelijk voor de hoge sterfte onder bijen. Nee, toont Wagenings onderzoek aan. Intussen lijkt het met de sterfte voorzichtig de goede kant op te gaan.

Adolf Mayer (1843-1942) en zijn betekenis voor de Virologie als wetenschap

NARCIS (Netherlands)

Vlak, J.M.

2007-01-01

In 2007 is het 125 jaar geleden dat Adolf Mayer voor het eerst zijn baanbrekend werk over het besmettelijk karakter van mozaiekziekte van tabak publiceerde (Mayer, 1882). Deze publicatie, in het Nederlands, in het Groningse Tijdschrift voor Landbouwkunde, markeert het begin van de virologie als

A. Feitsma, Tussen Hemsterhuis en Grimm. Joast Hiddes Halbertsma als taalkundige

NARCIS (Netherlands)

van der Geest, E.; van der Kuip, F.J.; Noordegraaf, J.

2012-01-01

Leven en werk van de taalkundige, schrijver en predikant Joast Hiddes Halbertsma 1789-1869) hebben steeds opnieuw de aandacht weten te trekken, zowel in Friesland als daarbuiten. In de jaren 1994-2003 heeft Tony Feitsma (1928-2009) uitgebreid onderzoek verricht naar de veelzijdige Friese

De wereld in 18 lessen: Christopher Williams

NARCIS (Netherlands)

Berrebi, S.

2011-01-01

Hij is een echte artist’s artist, de conceptuele fotograaf Christopher Williams. Sinds hij in Duitsland woont en werkt, vindt zijn afgewogen werk, dat de fotografie tegelijk eert en ondervraagt, steeds makkelijker onderdak in Europese kunstinstituten, zoals dit voorjaar bij Museum Dhondt-Dhaenens in

Burnout : de stand van zaken

NARCIS (Netherlands)

Taris, T.; Houtman, I.L.D.; Schaufeli, W.

2013-01-01

Dit artikel geeft een overzicht van de stand van zaken in het onderzoek naar burnout. Burnout is een syndroom van extreme vermoeidheid (uitputting), afstand nemen van het werk (distantie) en weinig vertrouwen in het eigen kunnen (verminderde competentie), waarbij de oorzaken voor deze aspecten

Verkennende bacteriologische zwemwaterbeoordeling volgens EU richtlijn 2006/7/EG

NARCIS (Netherlands)

Slijkerman, D.M.E.; Heusinkveld, J.H.T.

2007-01-01

Op 24 maart 2006 trad de nieuwe zwemwaterrichtlijn (76/160/EEG) in werking. Deze richt zich op de bescherming van de gezondheid van de zwemmer. De richtlijn toetst op bacteriologische parameters (totaal coliformen en fecale coliformen) ter voorkoming van maag- en darmklachten, maar ook meer

Verandering in ervaren stress en herstel bij teamsporters: gezond vs. geblesseerd

NARCIS (Netherlands)

M.S. Brink; Koen A.P.M. Lemmink; H.T.D. van der Does

2014-01-01

Teamsporters hebben een hoog blessure risico. Verondersteld wordt dat psychosociale stress en herstel bijdragen aan het blessurerisico. Zo zal een sporter die veel stress heeft van werk of studie dezelfde fysieke belasting zwaarder ervaren. Het is daarom belangrijk om inzicht te krijgen in de

Banken horen niet thuis op de beurs

NARCIS (Netherlands)

Romme, A.G.L.

2012-01-01

De zelfregulerende werking van banken is een illusie gebleken. Keer op keer blijken bankiers niet in staat zijn om zelf de gewenste structuurverbeteringen in gang te zetten. De Eindhovense econoom Romme pleit daarom voor een fundamentele transformatie van de bancaire wereld, vanuit het basisidee dat

Een moslim als gemeentelijk bruggenbouwer? Het ontslag van Tariq Ramadan

NARCIS (Netherlands)

Wiegers, G.; van Zessen, N.

2009-01-01

Het ontslag van Tariq Ramadan heeft veel ophef veroorzaakt. De doorslag gaf zijn werk voor Press TV. Gerard Wiegers en Nelleke van Zessen stellen, net zoals Ramadan zelf, dat de controverse rond zijn opvattingen over homoseksualiteit het kernprobleem vormde. Ramadan bleek niet de vrijzinnige moslim

25 jaar (uitsluiting van het) Weens Koopverdrag in Nederland

NARCIS (Netherlands)

Kruisinga, S.A.

Op 1 januari 2017 was het precies 25 jaar geleden dat het Weens Koopverdrag (CISG) in Nederland in werking trad. Partijen bij een internationale koopovereenkomst kunnen de toepassing van dit verdrag geheel of gedeeltelijk uitsluiten (art. 6 CISG). Van deze mogelijkheid wordt in de praktijk

"This one is stronger" : Spotlights on the lifelong learning professional-in-action

NARCIS (Netherlands)

van der Linden, Josje

2016-01-01

Om te kunnen omgaan met de veranderende realiteit in leven en werk, wordt wereldwijd een leven lang leren aangemoedigd. Het vierde duurzame ontwikkelingsdoel, vastgesteld in september 2015, weerspiegelt dit: “het verzekeren van kwalitatief goed onderwijs en het bevorderen van de mogelijkheden om een

Incoterms in de internationale handelspraktijk

NARCIS (Netherlands)

Sonja van Hall

2011-01-01

Op 1 januari 2011 zijn de nieuwe Incoterms 2010 in werking getreden. De benaming Incoterms is een acroniem voor International Commercial Terms, een set handelstermen die wordt beschreven en uitgegeven door de Internationale Kamer van Koophandel te Parijs. Het opstellen van een nieuwe set Incoterms

El empresario agricola en el jugoso negocio de las frutas y hortalizas de Mexico

NARCIS (Netherlands)

Gonzalez Chavez, H.

1994-01-01

Dit werk heeft als doel om het veranderingsproces uit te leggen dat een landbouwstreek heeft ondergaan door de komst van een van oorsprong Noordamerikaanse exportondernemingen van landbouwprodukten. Deze ondernemingen zijn op grote schaal met de verbouw begonnen van groenten en fruit voor de

(Siegfried), Helena Gunter

African Journals Online (AJOL)

Siegfried),. Helena Gunter (Op 'n plaas in Afrika) en verder terug in die tyd: Spoor (Sonja Loots), Kom slag. 'n bees (Izak de Vries) asook werke van Jaco. Botha, Tom Dreyer en andere. In die onlangse verlede was daar ook Maal van Nicole Jaekel ...

Florence voorbij? : over verplegen, passie & wetenschappelijk onderzoek

NARCIS (Netherlands)

Schuurmans, M.J.

2010-01-01

Honderd jaar geleden overleed Florence Nightingale, zonder twijfel de bekendste verpleegkundige ooit. Nightingale wordt vaak geassocieerd met haar roeping voor de zorg. Haar werk in de Krimoorlog leverde haar de bijnaam ‘the lady with the lamp’ op. In verpleegkundige kringen wordt Nightingale tot op

Reductie van complexiteit binnen IFRS: wie is aan zet?

NARCIS (Netherlands)

Brouwer, A.; Tahtah, J.

2012-01-01

IFRS heeft bijgedragen aan de transparantie van financiële verslaggeving en efficiënte werking van kapitaalmarkten. IFRS wordt echter ook regelmatig bekritiseerd vanwege haar complexiteit. Deze complexiteit ondermijnt de begrijpelijkheid van financiële verslaggeving. In dit artikel gaan we in op een

Theoretical models for Type I and Type II supernova

International Nuclear Information System (INIS)

Woosley, S.E.; Weaver, T.A.

1985-01-01

Recent theoretical progress in understanding the origin and nature of Type I and Type II supernovae is discussed. New Type II presupernova models characterized by a variety of iron core masses at the time of collapse are presented and the sensitivity to the reaction rate 12 C(α,γ) 16 O explained. Stars heavier than about 20 M/sub solar/ must explode by a ''delayed'' mechanism not directly related to the hydrodynamical core bounce and a subset is likely to leave black hole remnants. The isotopic nucleosynthesis expected from these massive stellar explosions is in striking agreement with the sun. Type I supernovae result when an accreting white dwarf undergoes a thermonuclear explosion. The critical role of the velocity of the deflagration front in determining the light curve, spectrum, and, especially, isotopic nucleosynthesis in these models is explored. 76 refs., 8 figs

77 FR 52264 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

Science.gov (United States)

2012-08-29

... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... Airworthiness Directive (AD): Hughes Helicopters Inc., and McDonnel Douglas Helicopter Systems (Type Certificate...

Direct and indirect effects of different types of microplastics on freshwater prey (Corbicula fluminea) and their predator (Acipenser transmontanus)

Science.gov (United States)

Parnis, J. Mark; Browne, Mark A.; Serrato, Sebastian; Reiner, Eric J.; Robson, Matthew; Young, Thomas; Diamond, Miriam L.; Teh, Swee J.

2017-01-01

We examined whether environmentally relevant concentrations of different types of microplastics, with or without PCBs, directly affect freshwater prey and indirectly affect their predators. Asian clams (Corbicula fluminea) were exposed to environmentally relevant concentrations of polyethylene terephthalate (PET), polyethylene, polyvinylchloride (PVC) or polystyrene with and without polychlorinated biphenyls (PCBs) for 28 days. Their predators, white sturgeon (Acipenser transmontanus), were exposed to clams from each treatment for 28 days. In both species, we examined bioaccumulation of PCBs and effects (i.e., immunohistochemistry, histology, behavior, condition, mortality) across several levels of biological organization. PCBs were not detected in prey or predator, and thus differences in bioaccumulation of PCBs among polymers and biomagnification in predators could not be measured. One of the main objectives of this study was to test the hypothesis that bioaccumulation of PCBs would differ among polymer types. Because we could not answer this question experimentally, a bioaccumulation model was run and predicted that concentrations of PCBs in clams exposed to polyethylene and polystyrene would be greater than PET and PVC. Observed effects, although subtle, seemed to be due to microplastics rather than PCBs alone. For example, histopathology showed tubular dilation in clams exposed to microplastics with PCBs, with only mild effects in clams exposed to PCBs alone. PMID:29108004

Direct and indirect effects of different types of microplastics on freshwater prey (Corbicula fluminea and their predator (Acipenser transmontanus.

Directory of Open Access Journals (Sweden)

Chelsea M Rochman

Full Text Available We examined whether environmentally relevant concentrations of different types of microplastics, with or without PCBs, directly affect freshwater prey and indirectly affect their predators. Asian clams (Corbicula fluminea were exposed to environmentally relevant concentrations of polyethylene terephthalate (PET, polyethylene, polyvinylchloride (PVC or polystyrene with and without polychlorinated biphenyls (PCBs for 28 days. Their predators, white sturgeon (Acipenser transmontanus, were exposed to clams from each treatment for 28 days. In both species, we examined bioaccumulation of PCBs and effects (i.e., immunohistochemistry, histology, behavior, condition, mortality across several levels of biological organization. PCBs were not detected in prey or predator, and thus differences in bioaccumulation of PCBs among polymers and biomagnification in predators could not be measured. One of the main objectives of this study was to test the hypothesis that bioaccumulation of PCBs would differ among polymer types. Because we could not answer this question experimentally, a bioaccumulation model was run and predicted that concentrations of PCBs in clams exposed to polyethylene and polystyrene would be greater than PET and PVC. Observed effects, although subtle, seemed to be due to microplastics rather than PCBs alone. For example, histopathology showed tubular dilation in clams exposed to microplastics with PCBs, with only mild effects in clams exposed to PCBs alone.

78 FR 7642 - Airworthiness Directives; Piper Aircraft, Inc.

Science.gov (United States)

2013-02-04

... Airworthiness Directives; Piper Aircraft, Inc. AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain Piper Aircraft, Inc. (type certificate previously held by The New Piper Aircraft Inc.) PA-28, PA-32, PA-34, and PA-44...

78 FR 18226 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

Science.gov (United States)

2013-03-26

... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... directive (AD): 2013-05-16 Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type...

Semantics-Based Compiling: A Case Study in Type-Directed Partial Evaluation

DEFF Research Database (Denmark)

Danvy, Olivier; Vestergaard, René

1996-01-01

, block-structured, higher-order, call-by-value, allows subtyping, and obeys stack discipline. It is bigger than what is usually reported in the literature on semantics-based compiling and partial evaluation. Our compiling technique uses the first Futamura projection, i.e., we compile programs......-directed compilation, in the spirit of Scott and Strachey. Our conclusion is that lambda-calculus normalization suffices for compiling by specializing an interpreter....

Semantics-based compiling: A case study in type-directed partial evaluation

DEFF Research Database (Denmark)

Danvy, Olivier; Vestergaard, René

1996-01-01

, block-structured, higher-order, call-by-value, allows subtyping, and obeys stack discipline. It is bigger than what is usually reported in the literature on semantics-based compiling and partial evaluation. Our compiling technique uses the first Futamura projection, i.e., we compile programs......-directed compilation, in the spirit of Scott and Strachey. Our conclusion is that lambda-calculus normalization suffices for compiling by specializing an interpreter....

Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer.

Science.gov (United States)

Richter, Corinna; Dy, Ron L; McKenzie, Rebecca E; Watson, Bridget N J; Taylor, Corinda; Chang, James T; McNeil, Matthew B; Staals, Raymond H J; Fineran, Peter C

2014-07-01

Clustered regularly interspaced short palindromic repeats (CRISPR), in combination with CRISPR associated (cas) genes, constitute CRISPR-Cas bacterial adaptive immune systems. To generate immunity, these systems acquire short sequences of nucleic acids from foreign invaders and incorporate these into their CRISPR arrays as spacers. This adaptation process is the least characterized step in CRISPR-Cas immunity. Here, we used Pectobacterium atrosepticum to investigate adaptation in Type I-F CRISPR-Cas systems. Pre-existing spacers that matched plasmids stimulated hyperactive primed acquisition and resulted in the incorporation of up to nine new spacers across all three native CRISPR arrays. Endogenous expression of the cas genes was sufficient, yet required, for priming. The new spacers inhibited conjugation and transformation, and interference was enhanced with increasing numbers of new spacers. We analyzed ∼ 350 new spacers acquired in priming events and identified a 5'-protospacer-GG-3' protospacer adjacent motif. In contrast to priming in Type I-E systems, new spacers matched either plasmid strand and a biased distribution, including clustering near the primed protospacer, suggested a bi-directional translocation model for the Cas1:Cas2-3 adaptation machinery. Taken together these results indicate priming adaptation occurs in different CRISPR-Cas systems, that it can be highly active in wild-type strains and that the underlying mechanisms vary. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Tactile pavement for guiding walking direction: An assessment of heading direction and gait stability.

Science.gov (United States)

Pluijter, Nanda; de Wit, Lieke P W; Bruijn, Sjoerd M; Plaisier, Myrthe A

2015-10-01

For maintaining heading direction while walking we heavily rely on vision. Therefore, walking in the absence of vision or with visual attention directed elsewhere potentially leads to dangerous situations. Here we investigated whether tactile information from the feet can be used as a (partial) substitute for vision in maintaining a stable heading direction. If so, participants should be better able to keep a constant heading direction on tactile pavement that indicates directionality than on regular flat pavement. However, such a pavement may also be destabilizing. Thus we asked participants to walk straight ahead on regular pavement, and on tactile pavement (tiles with ridges along the walking direction) while varying the amount of vision. We assessed the effects of the type of pavement as well as the amount of vision on the variability of the heading direction as well as gait stability. Both of these measures were calculated from accelerations and angular velocities recorded from a smartphone attached to the participants trunk. Results showed that on tactile pavement participants had a less variations in their heading direction than on regular pavement. The drawback, however, was that the tactile pavement used in this study decreased gait stability. In sum, tactile pavement can be used as a partial substitute for vision in maintaining heading direction, but it can also decrease gait stability. Future work should focus on designing tactile pavement that does provided directional clues, but is less destabilizing. Copyright © 2015 Elsevier B.V. All rights reserved.

NASA directives: Master list and index

Science.gov (United States)

1994-01-01

This Handbook sets forth in two parts the following information for the guidance of users of the NASA Management Directives System. Chapter 1 contains introductory information material on how to use this Handbook. Chapter 2 is a complete master list of Agency-wide management directives, describing each directive by type, number, effective date, expiration date, title, and organization code of the office responsible for the directive. Chapter 3 includes a consolidated numerical list of all delegations of authority and a breakdown of such delegation by the office of Installation to which special authority is assigned. Chapter 4 sets forth a consolidated list of all NASA Handbooks (NHB's) and important footnotes covering the control and ordering of such documents. Chapter 5 is a consolidated list of NASA management directives applicable to the Jet Propulsion Laboratory. Chapter 6 is a consolidated list of NASA management directives published in the code of Federal Regulations. Complementary manuals to the NASA Management Directives System are described in Chapter 7. Part B contains an in-depth alphabetical index to all NASA management directives other than Handbooks.

Functions with non-isolated singularities on singular spaces

NARCIS (Netherlands)

Jiang, Guangfeng

1998-01-01

Dit proefschrift is een studie van functies op complexe singuliere ruimten met waarden in C . In het bijzonder behandelt het functies met niet-ge?soleerde singulariteiten. Het bouwt enerzijds voort op het werk van Dimca, Bruce- Roberts, Wall en Tibar over functies met ge?soleerde singulariteiten

Campagne begonnen: Samen sterk voor preventie

NARCIS (Netherlands)

Crone, A.

2012-01-01

De Europese campagne 'Samen sterk voor preventie', een initiatief van het Europees Agentschap voor veiligheid en gezondheid op het werk (EU-OSHA) in Bilbao, wordt in Nederland gecoördineerd door TNO/NL - Focal Point. Werkgevers- en werknemersorganisaties en de overheid werken hierin samen aan het

Nachruf für Hartmut Schulz : (13. Juli 1939 - 19. Juni 2003)

OpenAIRE

Klee, Rainer; Buttler, Karl Peter; Hodvina, Sylvain

2003-01-01

Am 19. Juni 2003 verstarb Hartmut Schulz, einer der Gründer der BVNH. Leben und Werk werden in einem durch Rainer Klee verfassten Nachruf gewürdigt. Es folgt eine von Karl Peter Buttler und Sylvain Hodvina erstellte Liste der Veröffentlichungen von Hartmut Schulz.

Vertrouwenswerk in de groei : de praktijk van de politie

NARCIS (Netherlands)

Nuyens, M.; Vries, S. de; Bossche, S.N.J. van den

2002-01-01

Het tegengaan van ongewenste omgangsvormen op het werk is al jaren een aandachtspunt binnen de Nederlandse politie. Het aanstellen van vertrouwenspersonen is één van de instrumenten die worden ingezet om ongewenste omgangsvormen tegen te gaan. Het NISSO stelde, op basis van een door hen uitgevoerd

Superplasticiteit bij Cern

NARCIS (Netherlands)

Snippe, Q.H.C.; Snippe, Corijn

2008-01-01

Op CERN, het Europees onderzoekscentrum voor subatomaire fysica in Genève, wordt dit jaar een nieuwe deeltjesversneller, de Large Hadron Collider (LHC), in werking gesteld die nieuwe inzichten moet bieden over hoe de kleinste deeltjes der materie zich gedragen. Om hierachter te komen, is op plaatsen

Consumentenonderzoek in het Restaurant van de Toekomst

NARCIS (Netherlands)

Wijk, de R.A.; Gorselink, M.; Steenbekkers, L.P.A.; Wabeke, M.; Thomasson, T.

2010-01-01

Miljoenen mensen lunchen dagelijks op hun werk. Over bijvoorbeeld motieven bij de keuze van maaltijdcomponenten, de invloed van de inrichting van het restaurant of variaties in het assortiment op dit keuzegedrag is weinig tot niets bekend. In het Restaurant van de Toekomst doet de Consumer Science

De beteekenis van het antivirus van Besredka in de heelkunde. Een klinisch-experimenteele studie

NARCIS (Netherlands)

Klein, Samuel Alexander

1934-01-01

Overzien wij de literatuur, welke naar aanleiding van Besredka's antivirus-theorie is ontstaan, dan treffen wij onder de zeer vele uiteenloopende meeningen en opvattingen één feit aan, waaromtrent het meerendeel van de onderzoekers eenzelfde zienswijze is toegedaan en wel dit feit, dat de werking

Mothers, work and childcare

NARCIS (Netherlands)

Ingrid Ooms; Evelien Eggink; Edwin van Gameren

2007-01-01

Original title: Moeders, werk en kinderopvang in model. The government wants women to go out to work more. The choices made by women between working and looking after children are accordingly receiving a great deal of attention. This report describes which factors influence these choices by

Inzicht in beslisgedrag maakt dat meer burgers meedoen

NARCIS (Netherlands)

Kerstholt, J.H.

2014-01-01

Participatiesamenleving Inzicht in beslisgedrag maakt dat meer burgers meedoen Waar was de bank van de dode buurvrouw? De sekte van de burgerkracht Al het werk is zingevend, ook het vrijwillige De ondernemende burger rukt op, schort het oordeel even op Blij met het luide debat over de

Het hoge woord : Beschouwingen en boutades

NARCIS (Netherlands)

Willemsen, August

2006-01-01

'Het is bij mij begonnen met nieuwsgierigheid', zo verwoordt August Willemsen (1936) zijn levenslange toewijding aan het vertalen, in het bijzonder van Portugese en Braziliaanse literatuur. In Het hoge woord schrijft hij virtuoos over leven en werk van de door hem in Nederland geïntroduceerde

Pyridine alcohols and thiols : Synthesis, properties and applications

NARCIS (Netherlands)

Koning, Bartjan

2000-01-01

Enzymen spelen in het leven van mens, dier en plant een enorm grote rol. Enzymen zijn biologische katalysatoren dwz. versnellers van (bio)chemische processen die zich in levende organismen afspelen. Enzymen zijn eiwitten die opgebouwd zijn uit aminozuren. Om meer inzicht te krijgen in de werking van

Het aanvullen van een leemte in de overeenkomst naar Nederlands en Engels recht

NARCIS (Netherlands)

Hendrikx, A.M.M.; Boom, van W.H.; Breedveld-de, Voogd C.G.; Castermans, A.G.; De, Deugd-Dijkman M.D.R.M.; Hijma, J.

2016-01-01

In deze bijdrage wordt stilgestaan bij de rol van de redelijkheid en billijkheid bij de aanvulling van een leemte in een overeenkomst naar Nederlands recht en de aanvullende werking van implied terms in het Engelse recht, waarbij ook gekeken zal worden naar de verschillen tussen beide

Trends in recent South African linguistic research | van Rooy ...

African Journals Online (AJOL)

Die primêre teoretiese vertrekpunte is die generatiewe paradigma vir werk oor die sintaksis van die Afrikatatale, kognitiewe linguistiek vir studies oor die sematiek in Afrikaans en die Semitiese tale en tipologiese funksionele benaderings en korpuslinguistiek. Nadat die tendense vasgestel is, word aandag gegee aan ...

Waardoor geraakt de Vlaamse werknemer gestresseerd?

NARCIS (Netherlands)

Van Ruysseveldt, Joris

2010-01-01

Op basis van het Job Demands-Resources (JD-R) model wordt gezocht naar een verklaring voor verschillen in niveaus van psychische vermoeidheid en plezier in het werk bij een representatieve steekproef uit de Vlaamse beroepsbevolking (N = 12.095). Het JD-R model veronderstelt dat de aanwezigheid van

Change Management

NARCIS (Netherlands)

Bouwhuijsen, van den W.J.M.J.

2008-01-01

In dit artikel verstaan we onder "CHANGE MANAGEMENT" het managen van wijzigingen en toevoegingen van het te realiseren object gedurende het gehele bouwproces tot de oplevering van het werk, zoals ik deze vanuit mijn ervaringen beleef. Het onderhoud en beheer laten we buiten beschouwing, omdat deze

Working within limits

NARCIS (Netherlands)

Gerda Jehoel-Gijsbers

2010-01-01

Original title: Beperkt aan het werk. For many years, the Netherlands was known as a country with high levels of sickness absenteeism and a large number of incapacity benefit claimants. At European level, this was sometimes referred to as 'the Dutch disease'. Many policy measures later,

Brengt sport mensen in beweging?

NARCIS (Netherlands)

Cremer, R.

2011-01-01

De titel is natuurlijk niet letterlijk bedoeld. De onderliggende vraag is: gaat het in beweging komen dóór sport samen met het in beweging komen voor werk? Uiteenlopende effecten van beweging kunnen in dit verband worden aangehaald, zoals veranderingen in de energiehuishouding, fysieke behendigheid,

Hans Küng: "Projekt Weltethos "

OpenAIRE

Altmanninger, Maria

2002-01-01

Bei dieser Arbeit werde ich mich vor Allem auf zwei Werke beziehen: Küng,Hans:Projekt Weltethos.Piper.München 1990. Küng,Hans;Kuschel,Karl-Josef (Hg.):Weltfrieden durch Religionsfrieden.Die unter Punkt Acht aufgeführte Stellungnahme wurde ausschließlich von mir verfasst.

Deelname aan de samenleving van mensen met een beperking: participatiemonitor 2007.

NARCIS (Netherlands)

Hoogen, P. van den; Cardol, M.; Speet, M.; Spreeuwenberg, P.; Rijken, M.

2008-01-01

Hoe doen mensen met een beperking mee in de maatschappij? Mensen met een lichamelijke beperking wonen en werken meestal net als iedereen, en ook zij zijn niet altijd tevreden met hun werk. Mensen met een verstandelijke beperking wonen en werken vaak in een speciale omgeving. Het overheidsbeleid

Van Homo Ludens naar Homo Turisticus: regressie of stap in de menselijke evolutie?

NARCIS (Netherlands)

Lengkeek, J.

2009-01-01

In zijn afscheidsrede wilde hoogleraar Jaap Lengkeek (Wageningen Universiteit) terugblikken op een idee, een begrip, dat op zijn eigen werk de afgelopen jaren invloed heeft gehad. Het begrip dat hij hiervoor koos is 'Homo Ludens', de spelende mens, dat door de bekende historicus Johan Huizinga in

Particle Discrimination Experiment for Direct Energy Conversion

International Nuclear Information System (INIS)

Yasaka, Y.; Kiriyama, Y.; Yamamoto, S.; Takeno, H.; Ishikawa, M.

2005-01-01

A direct energy conversion system designed for D- 3 He fusion reactor based on a field reversed configuration employs a venetian-blind type converter for thermal ions to produce DC power and a traveling wave type converter for fusion protons to produce RF power. It is therefore necessary to separate, discriminate, and guide the particle species. For this purpose, a cusp magnetic field is proposed, in which the electrons are deflected and guided along the field line to the line cusp, while the ions pass through the point cusp. A small-scale experimental device was used to study the basic characteristics of discrimination of electrons and ions in the cusp magnetic field. Ions separated from electrons are guided to an ion collector, which is operated as a one-stage direct energy converter. The conversion efficiency was measured for cases with different values of mean and spread of ion energy. These experiments successfully demonstrate direct energy conversion from plasma beams using particle discrimination by a cusp magnetic field

A Direction Sensitive Fast Neutron Monitor

Energy Technology Data Exchange (ETDEWEB)

Antolkovic, B; Holmqvist, B; Wiedling, T

1964-06-15

A direction sensitive fast neutron monitor is described and its properties are discussed in some detail. The counter is a modification of the standard long counter of the Hanson and McKibben type. Directional sensitivity is obtained by increasing the shielding of the counter and providing it with a 70 cm long collimator channel. The behaviour of this long counter monitor is compared with that of a standard long counter when both are used in neutron experiments.

Asynchronous machines. Direct torque control; Machines asynchrones. Commande par controle direct de couple

Energy Technology Data Exchange (ETDEWEB)

Fornel, B. de [Institut National Polytechnique, 31 - Toulouse (France)

2006-05-15

The asynchronous machine, with its low cost and robustness, is today the most widely used motor to make speed variators. However, its main drawback is that the same current generates both the magnetic flux and the torque, and thus any torque variation creates a flux variation. Such a coupling gives to the asynchronous machine a nonlinear behaviour which makes its control much more complex. The direct self control (DSC) method has been developed to improve the low efficiency of the scalar control method and for the specific railway drive application. The direct torque control (DTC) method is derived from the DSC method but corresponds to other type of applications. The DSC and DTC algorithms for asynchronous motors are presented in this article: 1 - direct control of the stator flux (DSC): principle, flux control, torque control, switching frequency of the inverter, speed estimation; 2 - direct torque control (DTC): principle, electromagnetic torque derivative, signals shape and switching frequency, some results, DTC speed variator without speed sensor, DTC application to multi-machine multi-converter systems; 3 - conclusion. (J.S.)

Werkboek agressie en pesten op het werk

NARCIS (Netherlands)

Evers, G.; Hubert, A.; Kroft, F. van der; Nuyens, M.; Willemsen, M.; Sluijs, R. van der; Davits, R.; Rijcken, V.

2003-01-01

Sommige gemeentelijke ambtenaren komen in aanraking met agressief gedrag van klanten. De redenen voor dit agressieve gedrag zijn uiteenlopend. Zo wil de ene klant zijn frustratie uiten en wil de ander iets gedaan krijgen van de betrokken werknemer. Zulk gedrag is onacceptabel en gemeentebestuurders

Metageschiedenis in het werk van Peter Blum

African Journals Online (AJOL)

vluchtte de familie voor Hitler, want er zijn aanwijzigingen dat Blum of in elk geval zijn moeder joods was (haar meisjesnaam was Levi). Om vast te stellen of Blum inderdaad joods was, heeft Blums biograaf Kannemeyer zelfs discreet bij een niet nader genoemde getuige geïnformeerd of hij besneden was, hetgeen niet het ...

Sexualität im Werk Arno Schmidts

OpenAIRE

Reischert, Jessica

2006-01-01

Die Sexualität im Frühwerk Arno Schmidts stellt ein umfangreiches und komplexes Thema dar, das dennoch auf gewisse Grundmuster und –vorgänge reduziert werden kann. So haben sich bei der Begegnung von Menschen untereinander klare Linien ergeben, anhand derer viele Gespräche eingeordnet und analysiert werden können. Unterschieden werden können mehrere Gesprächstypen, in denen sich bestimmte Verhaltensweisen der Schmidtschen Protagonisten zeigen: In den geschlechtlich gemischten Gesprächsrunden ...

Bohuslav Martinů – Werk und Wirkung [...

Czech Academy of Sciences Publication Activity Database

Gabrielová, Jarmila

2009-01-01

Roč. 46, č. 4 (2009), s. 429-431 ISSN 0018-7003 Institutional research plan: CEZ:AV0Z90580513 Keywords : Bohuslav Martinů (1890–1959) * selected music ological events 2009 Subject RIV: AL - Art, Architecture, Cultural Heritage

Verkeersonveiligheid bij werk in uitvoering : een literatuurstudie.

NARCIS (Netherlands)

Gent, A.L. van

2007-01-01

This report deals with the results of the first phase of the Road Safety at Roadworks study that CROW has commissioned SWOV to carry out. It consists of a literature study and a review of useful sources for crash data and data of road works. The main goals are (1) increasing insight into the number,

Het juiste werk voor een bijzonder talent?

NARCIS (Netherlands)

Wijn, R.; Kleij, R. van der

2012-01-01

TNO draagt met diverse onderzoeken bij aan het ontwikkelen en toepassen van kennis om de effectiviteit van cameratoezicht te vergroten. Dit artikel beschrijft een onderzoek naar de mogelijkheid om mensen met stoornissen in het autistische spectrum in te zetten in cameratoezichtcentrales.

Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax.

Science.gov (United States)

Jeong, Soo-Jin; Lu, Hanxin; Cho, Won-Kyung; Park, Hyeon Ung; Pise-Masison, Cynthia; Brady, John N

2006-10-01

In this study, we demonstrate that the coactivator-associated arginine methyltransferase 1 (CARM1), which methylates histone H3 and other proteins such as p300/CBP, is positively involved in the regulation of Tax transactivation. First, transfection studies demonstrated that overexpression of CARM1 wild-type protein resulted in increased Tax transactivation of the human T-cell lymphotropic virus type 1 (HTLV-1) long terminal repeat (LTR). In contrast, transfection of a catalytically inactive CARM1 methyltransferase mutant did not enhance Tax transactivation. CARM1 facilitated Tax transactivation of the CREB-dependent cellular GEM promoter. A direct physical interaction between HTLV-1 Tax and CARM1 was demonstrated using in vitro glutathione S-transferase-Tax binding assays, in vivo coimmunoprecipitation, and confocal microscopy experiments. Finally, chromatin immunoprecipitation analysis of the activated HTLV-1 LTR promoter showed the association of CARM1 and methylated histone H3 with the template DNA. In vitro, Tax facilitates the binding of CARM1 to the transcription complex. Together, our data provide evidence that CARM1 enhances Tax transactivation of the HTLV-1 LTR through a direct interaction between CARM1 and Tax and this binding promotes methylation of histone H3 (R2, R17, and R26).

Fabrication of a direct Z-scheme type WO{sub 3}/Ag{sub 3}PO{sub 4} composite photocatalyst with enhanced visible-light photocatalytic performances

Energy Technology Data Exchange (ETDEWEB)

Lu, Jinsuo, E-mail: lujinsuo@xauat.edu.cn [School of Environmental and Municipal Engineering, Xi’an University of Architecture and Technology, Xi’an 710055 (China); Wang, Yujing [School of Materials and Chemical Engineering, Xi’an Technological University, Xi’an, Shaanxi 710032 (China); Liu, Fei [School of Environmental and Municipal Engineering, Xi’an University of Architecture and Technology, Xi’an 710055 (China); Zhang, Liang [College of Sciences, Xi’an University of Architecture and Technology, Xi’an 710055 (China); Chai, Shouning, E-mail: s.n.chai@xauat.edu.cn [College of Sciences, Xi’an University of Architecture and Technology, Xi’an 710055 (China)

2017-01-30

Highlights: • A solid direct Z-scheme type photocatalyst WO{sub 3}/Ag{sub 3}PO{sub 4} was synthesized. • The WO{sub 3}/Ag{sub 3}PO{sub 4} composite showed enhanced photocatalytic activity and stability. • Nearly complete removal of organic dyes was achieved in a short time. • The reasonable Z-scheme mechanism of WO{sub 3}/Ag{sub 3}PO{sub 4} composite was proposed. - Abstract: A direct Z-scheme type photocatalyst WO{sub 3}/Ag{sub 3}PO{sub 4} composite (molar ration 1:1, 1W/1Ag) was prepared by hydrothermal method. The 1W/1Ag was characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD), UV–vis diffuse reflection spectroscopy (DRS), X-ray photoelectron spectroscopy (XPS), and photoluminescence emission spectroscopy (PL) etc. technologies. The photocatalytic performances were evaluated by degradation of methylene blue (MB) and methyl orange (MO), and their removal rates were up to 95% after 60 min and 90% after 180 min, respectively. The prepared 1W/1Ag exhibits a much higher photocatalytic activity than pure Ag{sub 3}PO{sub 4} and pure WO{sub 3} under visible light irradiation. The apparent rate constants of MB and MO degradation on 1W/1Ag are about 2.4 and 2.5 times that of pure Ag{sub 3}PO{sub 4}, respectively. The enhanced performance of the 1W/1Ag is attributed to a synergistic effect including relatively high surface area, strong light absorption, matched energy band structure, and the improved separation of photogenerated charge carriers between the two components. A reasonable Z-scheme mechanism referring to directed migration of photoinduced carriers was proposed. Thus, it can be suggested that the 1W/1Ag can serve as a promising photocatalyst for environmental purification and clean energy utilization.

Chemical compound-based direct reprogramming for future clinical applications

Science.gov (United States)

Takeda, Yukimasa; Harada, Yoshinori; Yoshikawa, Toshikazu; Dai, Ping

2018-01-01

Recent studies have revealed that a combination of chemical compounds enables direct reprogramming from one somatic cell type into another without the use of transgenes by regulating cellular signaling pathways and epigenetic modifications. The generation of induced pluripotent stem (iPS) cells generally requires virus vector-mediated expression of multiple transcription factors, which might disrupt genomic integrity and proper cell functions. The direct reprogramming is a promising alternative to rapidly prepare different cell types by bypassing the pluripotent state. Because the strategy also depends on forced expression of exogenous lineage-specific transcription factors, the direct reprogramming in a chemical compound-based manner is an ideal approach to further reduce the risk for tumorigenesis. So far, a number of reported research efforts have revealed that combinations of chemical compounds and cell-type specific medium transdifferentiate somatic cells into desired cell types including neuronal cells, glial cells, neural stem cells, brown adipocytes, cardiomyocytes, somatic progenitor cells, and pluripotent stem cells. These desired cells rapidly converted from patient-derived autologous fibroblasts can be applied for their own transplantation therapy to avoid immune rejection. However, complete chemical compound-induced conversions remain challenging particularly in adult human-derived fibroblasts compared with mouse embryonic fibroblasts (MEFs). This review summarizes up-to-date progress in each specific cell type and discusses prospects for future clinical application toward cell transplantation therapy. PMID:29739872

Compactly Supported Curvelet-Type Systems

DEFF Research Database (Denmark)

Rasmussen, Kenneth Niemann; Nielsen, Morten

2012-01-01

We study a flexible method for constructing curvelet-type frames. These curvelet-type systems have the same sparse representation properties as curvelets for appropriate classes of smooth functions, and the flexibility of the method allows us to give a constructive description of how to construct...... curvelet-type systems with a prescribed nature such as compact support in direct space. The method consists of using the machinery of almost diagonal matrices to show that a system of curvelet molecules which is sufficiently close to curvelets constitutes a frame for curvelet-type spaces. Such a system...

Visual coding with a population of direction-selective neurons.

Science.gov (United States)

Fiscella, Michele; Franke, Felix; Farrow, Karl; Müller, Jan; Roska, Botond; da Silveira, Rava Azeredo; Hierlemann, Andreas

2015-10-01

The brain decodes the visual scene from the action potentials of ∼20 retinal ganglion cell types. Among the retinal ganglion cells, direction-selective ganglion cells (DSGCs) encode motion direction. Several studies have focused on the encoding or decoding of motion direction by recording multiunit activity, mainly in the visual cortex. In this study, we simultaneously recorded from all four types of ON-OFF DSGCs of the rabbit retina using a microelectronics-based high-density microelectrode array (HDMEA) and decoded their concerted activity using probabilistic and linear decoders. Furthermore, we investigated how the modification of stimulus parameters (velocity, size, angle of moving object) and the use of different tuning curve fits influenced decoding precision. Finally, we simulated ON-OFF DSGC activity, based on real data, in order to understand how tuning curve widths and the angular distribution of the cells' preferred directions influence decoding performance. We found that probabilistic decoding strategies outperformed, on average, linear methods and that decoding precision was robust to changes in stimulus parameters such as velocity. The removal of noise correlations among cells, by random shuffling trials, caused a drop in decoding precision. Moreover, we found that tuning curves are broad in order to minimize large errors at the expense of a higher average error, and that the retinal direction-selective system would not substantially benefit, on average, from having more than four types of ON-OFF DSGCs or from a perfect alignment of the cells' preferred directions. Copyright © 2015 the American Physiological Society.

Neuroblabla

NARCIS (Netherlands)

Delleman, Otto

2012-01-01

De laatste decennia groeit de kennis over de werking van de hersenen explosief. Frank (2010) haalt met instemming de bekende neuroloog Ramachandran aan, die beweert dat we op de drempel van een vijfde revolutie staan. De eerste werd teweeggebracht door Copernicus met zijn claim dat de aarde niet het

Beloken blikvelden in de Lage Landen: Eenentwintigste-eeuwse ...

African Journals Online (AJOL)

De verkennende studies willen vooral van “historisch-documentaire” aard zijn en een beeld construeren waaruit blijkt hoe het vertaalde literaire werk door de. Nederlandse (en Vlaamse) kritiek is gerecipieerd. In hoeverre deze recent (her)- uitgegeven Afrikaanse poëzie ook effectief verweven is geraakt in het Nederlandse.

Het effect van het bijvoeren van tarwe aan vleeskuikens op de slachtrendementen

NARCIS (Netherlands)

Middelkoop, van J.H.; Harn, van J.

1994-01-01

Tarwe bijvoeren aan vleeskuikens staat momenteel volop in de belangstelling. Redenen hiervoor zijn de lage prijs van de tarwe en het positieve effect dat tarwe kan hebben op de resultaten en gezondheid van de koppel. Door het bijvoeren van tarwe wordt de werking van de spiermaag en de ontwikkeling

Het nieuwe Jeruzalem komt uit de hemel : christelijke religie en seculiere utopie

NARCIS (Netherlands)

Verkerk, M.J.

2008-01-01

Nu de ChristenUnie meeregeert zien sommige christenen nieuwe kansen om orde op zaken te stellen op ethisch gebied. Maarten Verkerk wijst aan de hand van het werk van Francis Bacon en van de regering Bush op het grote gevaar om hoge doelen te stellen aan een machtspositie.

Fysieke belasting op acht melkveehouderijbedrijven : netwerkproject Noordoost Groningen

NARCIS (Netherlands)

Roelofs, P.F.M.M.; Kroeze, G.H.; Brandsma, J.H.

2005-01-01

On eight dairy farms, labour demand and labour efficiency were studied. In 2004, labour demand during a year was calculated using the computer model AgroWerk. To obtain detailed input data for this model the farmers recorded labour times, and all farms were visited to collect input data concerning

P. S. D DIE TEOLOGIESE HOOFGEDAGTES IN KIERKEGAARD SE ...

African Journals Online (AJOL)

Test

D.Phil. DIE TEOLOGIESE HOOFGEDAGTES IN KIERKEGAARD SE. STRYD TEEN DIE HEGELSE SISTEEM. A. INLEIDENDE OPMERKING. Ons is van oordeel dat dit ongetwyfeld paslik is om in ons waardering van die persoon en werk van prof. H. P. Wolmarans, oor die Deense denker en digter, Kierkegaard, te skrywe.

Door de ogen van de ander kijken: kunst als veranderkracht

NARCIS (Netherlands)

Smilde, Rineke

2015-01-01

Presentie gehouden bij een besloten expert meeting van de KNAW en de Boekmanstichting in Amsterdam. Door de ogen van de ander kijken: kunst als veranderkracht. Ik maak graag van de gelegenheid gebruik om iets te vertellen vanuit mijn werk als lector aan het PCC van de Hanzehogeschool Groningen.

Verbeelding en principes: Enkele implicaties van Dewey’s moraalfilosofie voor een vernieuwing van de hedendaagse ethiek

NARCIS (Netherlands)

Coeckelbergh, Mark

2007-01-01

In deze presentatie onderzoek ik hoe Dewey’s moraalfilosofie kan bijdragen aan een vernieuwing van de hedendaagse ethiek door te kijken naar de rol die Dewey ziet voor verbeelding en principes in moreel redeneren. Ik toon dat zijn werk kan gebruikt worden om te argumenteren voor een omwenteling in

The seed hunter in het spoor van Vavilov (interview met C. Kik)

NARCIS (Netherlands)

Zanderink, R.; Kik, C.

2013-01-01

Er moet voor een veredelaar een grote variatie aan plantmateriaal aanwezig zijn om uit te kunnen putten zodat onze gewassen, die vaak bestaan uit monoculturen, voor de toekomst veiliggesteld worden. Het vinden van die variatie is het werk van seed hunters of zadenverzamelaars. Eén van die seed

Mislukking en succes bij de ambulante behandeling van dwangneurose

NARCIS (Netherlands)

C.A.L. Hoogduin (Cornelis Antonius Leo)

1985-01-01

textabstractMet het werk van Meyer, Rachman, Foa en Emmelkamp is een belangrijke ontwikkeling op gang gekomen met betrekking tot de behandeling van parienten met een dwangneurose. Maakte het in het verleden niet zoveel uit op welke manier deze parienten behandeld werden, de laatste jaren is het vast

GEBED IN DIE LITURGIE: 'N PRAKTIES-TEOLOGIESE VERKENNING

African Journals Online (AJOL)

die erediens voorkom nie en anders is as vrye gebede wat gelowiges bid, byvoorbeeld tydens persoonlike stiltetyd of 'n sogenaamde “skietgebed” op enige gegewe moment. Oor die laasgenoemde soort liturgiese gebed bestaan baie bronne, byvoorbeeld die bekende werk van Taft (1993)1 in die Rooms-Katolieke tradisie ...

03 Wessels 03.pmd

African Journals Online (AJOL)

Tienie01

12 Jun 2006 ... benadering definieer. Maria Edgeworth (1767-1849) het byvoorbeeld na 'n realistiese uitbeelding van haar samelewing gestreef en word as 'n belangrike invloed op beide Sir Walter Scott se historiese werke en Jane Austen se sosiale romans beskou. (Albei skrywers het haar bewonder en. 03 Wessels 03.

Kein Handbuchwissen

Directory of Open Access Journals (Sweden)

Thomas Wetzstein

2006-01-01

Full Text Available Rezensiertes Werk: Otfried Krafft, Papsturkunde und Heiligsprechung. Die päpstlichen Kanonisationen vom Mittelalter bis zur Reformation. Ein Handbuch (Archiv für Diplomatik, Schriftgeschichte, Siegel- und Wappenkunde, Beiheft 9, Köln, Weimar, Wien: Böhlau 2005, XII, 1247 S., ISBN 3-412-25805-9

03 Rutgers

African Journals Online (AJOL)

Tom

Pa saka kara: (tomo I) historia di literatura Papiamentu. Willemstad: Fundashon Pierre. Lauffer. Claassen, Anton. 1992. De navelstreng van mijn taal; Poesia bibo di Aruba. Haarlem: In de Knipscheer. Debrot, Cola. 1985-1989. Verzameld werk. (zeven delen) Amsterdam: Meulenhoff. ———. 1985a. Naschrift op Dr. David ...

Working with impairments

NARCIS (Netherlands)

Maroesjka Versantvoort; Patricia van Echtelt

2012-01-01

Original title: Belemmerd aan het werk The Netherlands was long known as a country with high sickness absenteeism rates and a burgeoning group of people who were unfit for work. In response to this, many policy measures have been introduced in recent decades which attempt to limit the benefit

Over het belang van Temminck's „Discours préliminaire" voor de zoologische Nomenclatuur

NARCIS (Netherlands)

Mees, G.F.

1957-01-01

Het gewoonlijk als „Discours préliminaire" aangeduide artikel van Temminck heeft nimmer die aandacht van dierkundigen getrokken, die het, wegens zijn systematisch belang, verdient. Ten dele vindt dit stellig zijn oorzaak in de betrekkelijke zeldzaamheid van het werk, ten dele ook in het feit dat het

Hoe kbesp re kill J,tsl Boo kR e~~ie"~s

African Journals Online (AJOL)

en verbly- dend - dat daar nog uitgewers is wat bereid is om goeie boeke te bemark, ongeag die geringe aantallesers van histories-wetenskaplike werke. Kapt A. E. van daarsveldt. MEREDITH, Martin: The past is another country, Rhodesia. 1890-1979 London, Deutsch, 1979. Hierdie boek voorsien in 'n leemte betreffende.

11 TSjoen WEB 02.pmd

African Journals Online (AJOL)

Owner

de tekst. Als Nabokov of Beckett een eerder losgelaten (dat wil zeggen een publiek gemaakte) tekst bewerken voor een volgende uitgave, dan vindt de belangstellende op basis van drukvergelijkend tekstonderzoek indicaties van een bijgestelde visie op het literaire werk zelf. Bekend in het Nederlandse taalgebied en veel ...

14 Van Krevelen 02.pmd

African Journals Online (AJOL)

Owner

23 juni 2009 ... teiten en experimenten benadrukt, maar de publieke en kritische perceptie van zijn werk lijkt de fundamentele samenhang daarvan te miskennen, en reduceert het tot gefragmenteerde, op zichzelf staande aspecten. Poëzie is levenskunst. Als Breyten Breytenbach alleen maar poëzie had geschreven was ...

77 FR 71723 - Airworthiness Directives; The Boeing Company Airplanes

Science.gov (United States)

2012-12-04

... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) that applies to certain The Boeing Company Model 737-200, -200C, - 300, and -400 series... related investigative and corrective actions, and revise certain inspection types. This proposed AD would...

Interspecies radioimmunoassay for the major structural proteins of primate type-D retroviruses

International Nuclear Information System (INIS)

Colcher, D.; Teramoto, Y.A.; Schlom, J.

1977-01-01

A competition radioimmunoassay has been developed in which type-D retroviruses from three primate species compete. The assay utilizes the major structural protein (36,000 daltons) of the endogenous squirrel monkey retrovirus and antisera directed against the major structural protein (27,000 daltons) of the Mason-Pfizer monkey virus isolated from rhesus monkeys. Purified preparations of both viruses grown in heterologous cells, as well as extracts of heterologous cells infected with squirrel monkey retrovirus or Mason-Pfizer monkey virus, compete completely in the assay. Addition of an endogenous virus of the langur monkey also results in complete blocking. No blocking in the assay is observed with type-C baboon viruses, woolly monkey virus, and gibbon virus. Various other type-C and type-B viruses also showed no reactivity. An interspecies assay has thus been developed that recognizes the type-D retroviruses from both Old World monkey (rhesus and langur) and New World monkey (squirrel) species

Verbal directionality and argument alternation in Dinka

DEFF Research Database (Denmark)

Andersen, Torben

2012-01-01

The derivational morphology of verbs in Dinka includes a distinction between direction towards the deictic center (centripetal) and a direction not towards the deictic center (centrifugal). A goal adverbial requires a directional verb, and an object of such a verb refers to something that moves t...... of a simple verb may correspond to, respectively, a goal adverbial and an object of the directional verb. Another type of argument alternation results from the possibility of expressing a goal as an object of an applicative verb with an intransitive or transitive base.......(wards) an explicit or implicit goal. The object of a directional verb may play another role in the event described by the sentence than the object of the corresponding simple (and non-directional) verb. This gives rise to so-called argument alternation, in that, for instance, an object and an instrumental adverbial...

Direct energy conversion system for D-3He fusion

International Nuclear Information System (INIS)

Tomita, Y.; Shu, L.Y.; Momota, H.

1993-11-01

A novel and highly efficient direct energy conversion system is proposed for utilizing D- 3 He fueled fusion. In order to convert kinetic energy of ions, we applied a pair of direct energy conversion systems each of which has a cusp-type DEC and a traveling wave DEC (TWDEC). In a cusp-type DEC, electrons are separated from the escaping ions at the first line-cusp and the energy of thermal ion components is converted at the second cusp DEC. The fusion protons go through the cusp-type DEC and arrive at the TWDEC, which principle is similar to 'LINAC.' The energy of fusion protons is recovered to electricity with an efficiency of more than 70%. These DECs bring about the high efficient fusion plant. (author)

Mechanism and comparison of needle-type non-thermal direct and indirect atmospheric pressure plasma jets on the degradation of dyes

Science.gov (United States)

Attri, Pankaj; Yusupov, Maksudbek; Park, Ji Hoon; Lingamdinne, Lakshmi Prasanna; Koduru, Janardhan Reddy; Shiratani, Masaharu; Choi, Eun Ha; Bogaerts, Annemie

2016-10-01

Purified water supply for human use, agriculture and industry is the major global priority nowadays. The advanced oxidation process based on atmospheric pressure non-thermal plasma (NTP) has been used for purification of wastewater, although the underlying mechanisms of degradation of organic pollutants are still unknown. In this study we employ two needle-type atmospheric pressure non-thermal plasma jets, i.e., indirect (ID-APPJ) and direct (D-APPJ) jets operating at Ar feed gas, for the treatment of methylene blue, methyl orange and congo red dyes, for two different times (i.e., 20 min and 30 min). Specifically, we study the decolorization/degradation of all three dyes using the above mentioned plasma sources, by means of UV-Vis spectroscopy, HPLC and a density meter. We also employ mass spectroscopy to verify whether only decolorization or also degradation takes place after treatment of the dyes by the NTP jets. Additionally, we analyze the interaction of OH radicals with all three dyes using reactive molecular dynamics simulations, based on the density functional-tight binding method. This investigation represents the first report on the degradation of these three different dyes by two types of NTP setups, analyzed by various methods, and based on both experimental and computational studies.

Direct Analysis of Samples of Various Origin and Composition Using Specific Types of Mass Spectrometry.

Science.gov (United States)

Byliński, Hubert; Gębicki, Jacek; Dymerski, Tomasz; Namieśnik, Jacek

2017-07-04

One of the major sources of error that occur during chemical analysis utilizing the more conventional and established analytical techniques is the possibility of losing part of the analytes during the sample preparation stage. Unfortunately, this sample preparation stage is required to improve analytical sensitivity and precision. Direct techniques have helped to shorten or even bypass the sample preparation stage; and in this review, we comment of some of the new direct techniques that are mass-spectrometry based. The study presents information about the measurement techniques using mass spectrometry, which allow direct sample analysis, without sample preparation or limiting some pre-concentration steps. MALDI - MS, PTR - MS, SIFT - MS, DESI - MS techniques are discussed. These solutions have numerous applications in different fields of human activity due to their interesting properties. The advantages and disadvantages of these techniques are presented. The trends in development of direct analysis using the aforementioned techniques are also presented.

77 FR 42455 - Airworthiness Directives; Piper Aircraft, Inc. Airplanes

Science.gov (United States)

2012-07-19

...-0756; Directorate Identifier 2012-CE-012-AD] RIN 2120-AA64 Airworthiness Directives; Piper Aircraft... adopt a new airworthiness directive (AD) for all Piper Aircraft, Inc. (type certificate previously held by The New Piper Aircraft Inc.) Models PA-18 and PA-19 airplanes. This proposed AD was prompted by...

SPARK-UP; Seaweed Production And Refining of Kelp, Ulva and Palmaria

NARCIS (Netherlands)

Wald, J.; Visser, de W.; Brandenburg, W.A.; Jongschaap, R.E.E.; Werf, van der A.K.; Deelman, Berth-Jan; Helmendach-Nieuwenhuize, Carola

2016-01-01

In het SPARK-UP project, waarin de partners Arkema, PRI-WUR en North Seaweed samenwerkten aan de ontwikkeling van toepassing van zeewier in de biobased economy, is de afgelopen jaren veel werk verzet. In een bassin op het terrein van Arkema, heeft PRI een teeltsysteem opgezet en in gebruik genomen,

Gewalt ohne Monopol

Directory of Open Access Journals (Sweden)

Marc Grohmann

2003-01-01

Full Text Available Rezensiertes Werk:Peter Hanser, Trutz von Trotha, Ordnungsformen der Gewalt. Reflexionen über die Grenzen von Recht und Staat an einem einsamen Ort in Papua-Neuguinea (Siegener Beiträge zur Soziologie 3, Köln: Rüdiger Köppe 2002, 448 S., ISBN 3-89645-330-0

Jullie kunnen het Weststellingwerf!

NARCIS (Netherlands)

Heijne, Leo; Pierie, Frank

2017-01-01

Weststellingwerf werkt momenteel aan haar Omgevingsvisie en doet dit samen met de inwoners. Deze visie gaat over de toekomst van de woon-, werk- en leefomgeving van de gemeente Weststellingwerf. De gemeente moedigt in dit kader de inwoners aan om mee te denken en samen te "puzzelen" voor een

GE[)URE~[)E

African Journals Online (AJOL)

liter te orienteer. n. Direktoraat. Openbare. Betrekkinge is onder beheer van die Oorlogskantoor gestig en 'n aantal offisiere is aangestel. Hulle werk was om die Leer te beskrywe en soveel as moontlik in die openbare pers te laat verskyn. Hierdie organisasie het goeie vredestydse diens gelewer, maar sou die oorlogstyd ...

To work or not to work

NARCIS (Netherlands)

Patricia van Echtelt; Stella Hoff

2008-01-01

Original title: Wel of niet aan het werk. 'More people in paid work' is the central policy objective of the Dutch government in relation to employment. In order to achieve this goal, it is necessary to know what prevents non-workers from joining the labour process, and what prevents workers

Benjamin Constant, surveillance en de strijd voor vrijheid en privacy : Vergeten gevoeligheden in een door Jeremy Bentham beïnvloed veiligheidsklimaat

NARCIS (Netherlands)

de Hert, Paul; de Hert, P.; Kinneging, A.; Colette, M.

2015-01-01

In deze bijdrage, concentreer ik me op Benjamin Constants (1767-1830) Principes de politique, een meesterwerk van de liberale theorie. In dit werk uit 1810 geeft Constant zelf op verschillende plaatsen aan dat hij geschiedenis aan het schrijven is. Hij is, zo merkt hij op, de eerste om aandacht te

IN KRITIESE BESKOUING VAN INLEIDING TOT DIE SEMANTIEK

African Journals Online (AJOL)

Dit laat twee interpretasie- moontlikhede oop: "later" kan of beteken "later in Syntactic Structures. (Chomsky 1957)", of "tussen Syntactic Structures en Katz en Fodor (1963) se The Structure of a Semantic Theory". Laasgenoemde werk is naamlik die eerste wat deur De Klerk as deel van die tweede periode, "die aanloop tot.

Deon Meyer

African Journals Online (AJOL)

Owner

of ten minste gekontekstualiseer, word. By die gastehuis, La Petite Margaux, is daar drie lyke met drie perfekte kopskote. Twee van die oorledenes is militêre tipes, oud-SAPD- lyfwagte wat as persoonlike sekuriteitswagte vir Jeanette Louw, besturende direkteur van. Body Armour (soos in Onsigbaar en 7 dae), ge- werk het.

Turgot en Smith; een paar apart

NARCIS (Netherlands)

Hoyng, A.C.

2011-01-01

Anne-Claire Hoyng deed onderzoek naar het boek The Wealth of Nations van Adam Smith (1723-1790). Ze concludeert dat Smith voor het schrijven van zijn boek een werk van de Fransman Anne-Robert Jacques Turgot (1727-1781) als inspiratiebron gebruikte (Réflexions sur la Formation et la distribution des

Competition between informal care and paid work

NARCIS (Netherlands)

Edith Josten; Alice de Boer

2015-01-01

Oringinal title: Concurrentie tussen mantelzorg en betaald werk The Dutch government would like citizens to provide more care to loved ones who need it – perhaps caring for an elderly parent or looking after a partner with a long-term illness. At the same time, the government wishes to raise

RIVM open data

NARCIS (Netherlands)

van Loenen, B.; Welle Donker, F.M.; Ploeger, H.D.

2016-01-01

Onderzoek uitgevoerd in opdracth van RIVM.
Open data is een van de pijlers van onze informatie-economie en van een transparante overheid. Ook de minister van de minister van Volksgezondheid, Welzijn en Sport (VWS) heeft in 2015 aangekondigd werk te gaan maken van open data in de zorg. Naast het

Prestatieladder Socialer Ondernemen Handleiding versie 1.0

NARCIS (Netherlands)

Bongers, P.M.

2012-01-01

De PSO is het eerste objectieve meetinstrument dat de sociale bijdragen van bedrijven in kaart brengt. Aukje Smit, projectleider PSO bij TNO: “Met een PSO-erkenning kunnen de bedrijven die er echt werk van maken zich nu onderscheiden van de concurrent. Voor gemeenten en UWV is de PSO ook interessant

Recht en vrede bij Hans Kelsen : een herwaardering van Kelsens rechtsfilosofie : juridisch pacifisme als stilzwijgende betekenis van zijn Zuivere Rechtsleer

NARCIS (Netherlands)

Notermans, Mathijs Eugène

2016-01-01

Hans Kelsen staat in de wereld van de rechtsfilosofie en –theorie bekend als één van de belangrijkste rechtsgeleerden van de 20ste eeuw en zijn belangrijkste werk dat hem die bekendheid heeft opgeleverd, de Reine Rechtslehre, is dan ook ‘wereldberoemd’. Minder bekendheid geniet hij als juridisch

FORMS AND MOTIVATIONS OF FOREIGN DIRECT INVESTMENT

Directory of Open Access Journals (Sweden)

Maria-Ramona SÂRBU

2014-04-01

Full Text Available This study proposes the identification of forms of Foreign Direct Investment (FDI and analyzes factors influencing FDI motivation. Designing a coherent program to encourage foreign direct investment is based on knowledge of the factors that determine international companies to resort to this type of development: these companies resort to foreign direct investment if they have ownership advantages and internationalization, while another country has locational advantages to the company's home country. Thus, identifying the factors that influence the motivation of FDI is important both at the microeconomic level, local, local authorities and macroeconomic, national, government to develop measures for multiplying FDI .

Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma.

Science.gov (United States)

Jin, D Y; Giordano, V; Kibler, K V; Nakano, H; Jeang, K T

1999-06-18

Mechanisms by which the human T-cell leukemia virus type I Tax oncoprotein activates NF-kappaB remain incompletely understood. Although others have described an interaction between Tax and a holo-IkappaB kinase (IKK) complex, the exact details of protein-protein contact are not fully defined. Here we show that Tax binds to neither IKK-alpha nor IKK-beta but instead complexes directly with IKK-gamma, a newly characterized component of the IKK complex. This direct interaction with IKK-gamma correlates with Tax-induced IkappaB-alpha phosphorylation and NF-kappaB activation. Thus, our findings establish IKK-gamma as a key molecule for adapting an oncoprotein-specific signaling to IKK-alpha and IKK-beta.

Types for DSP Assembler Programs

DEFF Research Database (Denmark)

Larsen, Ken

2006-01-01

for reuse, and a procedure that computes point-wise vector multiplication. The latter uses a common idiom of prefetching memory resulting in out-of-bounds reading from memory. I present two extensions to the baseline type system: The first extension is a simple modification of some type rules to allow out......-ofbounds reading from memory. The second extension is based on two major modifications of the baseline type system: • Abandoning the type-invariance principle of memory locations and using a variation of alias types instead. • Introducing aggregate types, making it possible to have different views of a block...... of memory, thus enabling type checking of programs that directly manage and reuse memory. I show that both the baseline type system and the extended type system can be used to give type annotations to handwritten DSP assembler code, and that these annotations precisely and succinctly describe...

Employee-satisfaction: A triangulation approach

Directory of Open Access Journals (Sweden)

P. J. Visser

1997-06-01

Full Text Available The research on employee-satisfaction was conducted in the manufacturing industry. The sample consisted of 543 employees. The methodology could be described as a "triangulation approach" where a combination of quantitative and qualitative measurements were utilised and the results of both types of measurement integrated in the study of the construct. The research confirms existing findings that although the measurement of dimensions such as equitable rewards, working conditions, supportive colleagues, job content, etc. yield results on the level of employee-satisfaction, a single question, namely, "How satisfied are you with your job?" compares favourably with the general index. The findings also suggest the advantage of complimenting the quantitative data with qualitative information. The conclusions confirm the value of a qualitative method in cross-cultural research in an African environment. Opsomming Die navorsing omtrent werknemerstevredenheid is uitgevoer in die vervaardigingsbedryf. Die steekproef het bestaan uit 543 werknemers. Die metode van ondersoek kan beskryf word as 'n "driekantige benadering" (triangulation approach waar daar van kwantitatiewe en kwalitatiewe meting gebruik gemaak is en die resultate geihtegreer is in die bestudering van die konstruk. Die navorsing bevestig bestaande bevindinge dat die meting van dimensies soos vergelykbare belonings, werkstoestande, ondersteunende kollegas, inhoud van werk, ens. resultate lewer rakende die vlak van werknemerstevredenheid, 'n enkel vraag, naamlik, "Hoe tevrede is jy met jou werk?" gunstig vergelyk met die algemene indeks. Die bevindinge dui ook op die voordele van 'n benadering waar die kwantitatiewe data gekomplimenteer word deur kwalitatiewe inligting soos verkry uit individuele onderhoude. Die gevolgtrekkings bevestig die waarde wat die kwalitatiewe navorsingsmetode inhou vir kruis-kulturele navorsing in 'n Afrika konteks.

Direct Application of Rep-PCR on Type I Sourdough Matrix to Monitor the Dominance and Persistence of a Lactobacillus plantarum Starter Throughout Back-Slopping.

Science.gov (United States)

Dolci, Paola; Cocolin, Luca

2017-08-01

This study describes the optimization and application of repetitive element-PCR (rep-PCR) technique directly on microbial DNA extracted from type I sourdoughs for fast monitoring of a Lb. plantarum starter strain (P1FMC) throughout daily back-slopping. The challenge was to follow and study the performance of a starter culture directly in sourdoughs without cultivation on selective media. The extraction of good quality microbial DNA suitable for amplification from a complex matrix such as dough was the first target. In addition, the objective to obtain a clear rep-PCR profile referable to a specific starter strain among a microbial community was pursued. Co-inoculum trials, in flour matrix, with Lb. plantarum P1FMC and L. lactis LC71 strains and, subsequently, type I sourdough back-slopping trials were performed. The rep-PCR amplification profiles obtained were clearly referable to that of Lb. plantarum P1FMC starter in both co-inoculum trials (also when it was present with one order of magnitude less with respect to L. lactis LC71) and back-slopping trials where it dominated the fermentation process with loads of 10 8 cfu g -1 and prevailed on the autochthonous microbiota. Thus, the approach proposed in this paper could be considered a methodological advancement, based on a culture-independent one-step rep-PCR, suitable for fast monitoring of starter performance. © 2017 Institute of Food Technologists®.

Macrophage galactose-type C-type lectin receptor for DC targeting of antitumor glycopeptide vaccines

DEFF Research Database (Denmark)

Nuti, M; Zizzari, I; Napoletano, C

2011-01-01

e13528 Background: Dendritic cells (DCs) are the most potent antigen presenting cells and are employed in cancer vaccination. Several receptors are being studied in order to identif strategies to increase DCs activating capacity. The C-type lectin macrophage galactose type C-type lectin (MGL...... of IFNg and IL-2 secretion by both CD8 and CD4 T cells. CONCLUSIONS: These results demonstrate that MGL engagement profoundly affects DC plasticity inducing and directing a Th1 immune response. Moreover, MGL receptor expressed on human DC can be targeted by glycopeptide based vaccines with adjuvant...

[Direct costs of medical care for patients with type 2 diabetes mellitus in Mexico micro-costing analysis].

Science.gov (United States)

Rodríguez Bolaños, Rosibel de Los Ángeles; Reynales Shigematsu, Luz Myriam; Jiménez Ruíz, Jorge Alberto; Juárez Márquezy, Sergio Arturo; Hernández Ávila, Mauricio

2010-12-01

Estimate the direct cost of medical care incurred by the Mexican Social Security Institute (IMSS, Instituto Mexicano del Seguro Social) for patients with type 2 diabetes mellitus (DM2). The clinical files of 497 patients who were treated in secondary and tertiary medical care units in 2002-2004 were reviewed. Costs were quantified using a disease costing approach (DCA) from the provider's perspective, a micro-costing technique, and a bottom-up methodology. Average annual costs by diagnosis, complication, and total cost were estimated. Total IMSS DM2 annual costs were US$452 064 988, or 3.1% of operating expenses. The annual average cost per patient was US$3 193.75, with US$2 740.34 per patient without complications and US$3 550.17 per patient with complications. Hospitalization and intensive care bed-days generated the greatest expenses. The high cost of providing medical care to patients with DM2 and its complications represents an economic burden that health institutions should consider in their budgets to enable them to offer quality service that is both adequate and timely. Using the micro-costing methodology allows an approximation to real data on utilization and management of the disease.

Developments of directional detectors with NaI(Tl)/BGO scintillators

International Nuclear Information System (INIS)

Shirakawa, Y.

2004-01-01

This paper describes directional gamma ray detectors with different types of scintillators. The detectors, which positively increase directional sensitivity to incident gamma rays, have been developed to measure directions, energies and counts of gamma rays, and to search for radioactive materials such as orphan radioisotopes or contaminations. Experimental results have shown that proposed directional detectors have a potential for practical use in real fields and will contribute to radiation protection and safety

Design Preliminaries for Direct Drive under Water Wind Turbine Generator

DEFF Research Database (Denmark)

Leban, Krisztina Monika; Ritchie, Ewen; Argeseanu, Alin

2012-01-01

This paper focuses on the preliminary design process of a 20 MW electric generator. The application calls for an offshore, vertical axis, direct drive wind turbine. Arguments for selecting the type of electric machine for the application are presented and discussed. Comparison criteria for deciding...... on a type of machine are listed. Additional constraints emerging from the direct drive, vertical axis concepts are considered. General rules and a preliminary algorithm are discussed for the machine selected to be most suitable for the imposed conditions....

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

DEFF Research Database (Denmark)

Molnos, Sophie; Wahl, Simone; Haid, Mark

2018-01-01

) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes. Methods: We measured the levels of 188 metabolites in plasma samples from 130 healthy members of twin families......Aims/hypothesis: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1...... (from the Netherlands Twin Register) at five time points during a modified 3 h hyperglycaemic clamp with glucose, GLP-1 and arginine stimulation. We validated our results in cohorts with OGTT data (n = 340) and epidemiological case–control studies of prevalent (n = 4925) and incident (n = 4277...

Occupancy of a C2-C2 type 'zinc-finger' protein domain by copper. Direct observation by electrospray ionization mass spectrometry.

Science.gov (United States)

Hutchens, T W; Allen, M H; Li, C M; Yip, T T

1992-09-07

The metal ion specificity of most 'zinc-finger' metal binding domains is unknown. The human estrogen receptor protein contains two different C2-C2 type 'zinc-finger' sequences within its DNA-binding domain (ERDBD). Copper inhibits the function of this protein by mechanisms which remain unclear. We have used electrospray ionization mass spectrometry to evaluate directly the 71-residue ERDBD (K180-M250) in the absence and presence of Cu(II) ions. The ERDBD showed a high affinity for Cu and was completely occupied with 4 Cu bound; each Cu ion was evidently bound to only two ligand residues (net loss of only 2 Da per bound Cu). The Cu binding stoichiometry was confirmed by atomic absorption. These results (i) provide the first direct physical evidence for the ability of the estrogen receptor DNA-binding domain to bind Cu and (ii) document a twofold difference in the Zn- and Cu-binding capacity. Differences in the ERDBD domain structure with bound Zn and Cu are predicted. Given the relative intracellular contents of Zn and Cu, our findings demonstrate the need to investigate further the Cu occupancy of this and other zinc-finger domains both in vitro and in vivo.

Management of mydriasis and pain in cataract and intraocular lens surgery: review of current medications and future directions

Directory of Open Access Journals (Sweden)

Grob SR

2014-07-01

Full Text Available Seanna R Grob,1–3 Luis A Gonzalez-Gonzalez,1–3 Mary K Daly1,2,4 1Department of Ophthalmology, Veterans Administration Boston Healthcare System, Boston, MA, USA; 2Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; 3Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 4Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA Abstract: The maintenance of mydriasis and the control of postoperative pain and ­inflammation are critical to the safety and success of cataract and intraocular lens replacement surgery. Appropriate mydriasis is usually achieved by topical and/or intracameral administration of anticholinergic agents, sympathomimetic agents, or both, with the most commonly used being cyclopentolate, tropicamide, and phenylephrine. Ocular inflammation is common after cataract surgery. Topical steroids and nonsteroidal anti-inflammatory drugs are widely used because they have been proved effective to control postsurgical inflammation and decrease pain. Topical nonsteroidal anti-inflammatory drugs have also been shown to help maintain dilation. However, use of multiple preoperative drops for pupil dilation, inflammation, and pain control have been shown to be time consuming, resulting in delays to the operating room, and they cause dissatisfaction among perioperative personnel; their use can also be associated with systemic side effects. Therefore, ophthalmologists have been in search of new options to streamline this process. This article will review the current medications commonly used for intraoperative mydriasis, as well as pain and inflammation control. In addition, a new combination of ketorolac, an anti-inflammatory agent, and phenylephrine, a mydriatic agent has recently been designed to maintain intraoperative mydriasis and to reduce postoperative pain and irritation from intraocular lens replacement surgery. Two Phase III clinical trials evaluating this

Ueberreste vorweltlicher Proboscidier von Java und Banka

NARCIS (Netherlands)

Martin, K.

1884-01-01

Junghuhn führte in seinem Werke über Java nur einen einzigen Wirbelthierrest, Carcharias megalodon, an (7, IV, pag. 97); es war ihm nicht gelungen bei seinem ersten Aufenthalte auf der Insel Reste von Säugethieren zu finden, so eifrig er auch darnach in den Höhlen des Tertiaergebirges suchte (7, IV,

Bleek planeet

African Journals Online (AJOL)

Owner

king”) en verskynsels soos el niño word be- trek. Aardverwoesting, natuurverskynsels en die geïmpliseerde rol van die mens as (dikwels gefaalde) behoeder van die natuur word in hierdie bundel met deurdagte en suggestie- ryke taal onder woorde gebring. In Bleek planeet werk heelwat van die ge- digte intertekstueel.

Zo moet het gegaan zijn : De noodzaak van alternatieve verklaringen en bekritiseerbare analyses bij zoekzaken binnen de opsporing

NARCIS (Netherlands)

Wisse, B.W.; Gosliga, S.P.; Bijsterbosch, G.

2011-01-01

Recente justitiële dwalingen in onder andere de zaak Ina Post, de Schiedammer parkmoord, de Puttense moordzaak en de zaak Lucia de Berk laten zien dat het werk van een opsporingsteam vatbaar is voor het fenomeen tunnelvisie: het gevaar dat te veel wordt vastgehouden aan één scenario/hypothese. Een

20 Resensies 03 Senekal WEB.pmd

African Journals Online (AJOL)

Owner

'n Nuwe wildernismaak as geheel wel 'n bydrae tot die grensliteratuur, veral omdat dit as een van die meer omvangryke werke van fiksie wat oor hierdie oorlog verskyn het, daartoe in staat is om verskillende nuanses van die oorlog op te roep. So byvoorbeeld kom die be- vraagtekening van die redes waarom die.

De opname van het conflictenrecht in het Nederlandse BW: een analyse van de gevolgen ervan voor de systematiek en de coherentie van het BW in zijn geheel

NARCIS (Netherlands)

Oderkerk, A.E.

2013-01-01

Op 1 januari 2012 is Boek 10 BW in werking getreden. Daarmee is het grootste deel van het Nederlandse conflictenrecht thans in het BW opgenomen. In deze monografie, die een bewerking vormt van de door de auteur op 16 november 2010 gehouden lezing voor de ‘Studiekring Prof.mr. J. Offerhaus’, wordt

Art. 1 Eerste Protocol EVRM

NARCIS (Netherlands)

Poelmann, E.

2014-01-01

Het recht op bezit is niet in het Europees Verdrag ter bescherming van de rechten van de mens en de fundamentele vrijheden (hierna: EVRM) neergelegd, maar in het Eerste Protocol daarbij (hierna: EP), dat in 1954 in werking is getreden. Het is van belang voor ogen te houden dat de Tweede Wereldoorlog

belangstel. AD Pont. S. van der Linde ea, Roeping en Belofte. Ons ...

African Journals Online (AJOL)

Test

Hoogs interessant is die opmerking oor die bybedoelings wat dikwels met die sending saamgegaan het sodat die sending soms tot 'n vervlakte en gesekulariseerde filantropiese besigheid ge vord het. Hoe verwoestend dit werk, het ons hier in Suid-Afrika al meer as een maal ten duurste moes ondervind. Dit doen goed om.

Die gebruik van 'n handpop as mede- terapeut en 'n vyfjarige ...

African Journals Online (AJOL)

p1243322

waarmee Billy Beer werk en elemente soos humor en herhaling word gebruik om ouderdomstoepaslik teenoor haar te reageer en op so manier haar unieke. “taal” te praat. In die res van die artikel word eerstens aandag gegee aan sake van 'n metodologiese aard, insluitende die gebruik van die sentrale metafoor van 'n.

NASA directives master list and index

Science.gov (United States)

1995-01-01

This handbook sets forth in two parts, Master List of Management Directives and Index to NASA Management Directives, the following information for the guidance of users of the NASA Management Directives System. Chapter 1 contains introductory information material on how to use this handbook. Chapter 2 is a complete master list of agencywide management directives, describing each directive by type, number, effective date, expiration date, title, and organization code of the office responsible for the directive. Chapter 3 includes a consolidated numerical list of all delegations of authority and a breakdown of such delegation by the office or center to which special authority is assigned. Chapter 4 sets forth a consolidated list of all NASA handbooks (NHB's) and important footnotes covering the control and ordering of such documents. Chapter 5 is a consolidated list of NASA management directives applicable to the Jet Propulsion Laboratory. Chapter 6 is a consolidated list of NASA regulations published in the Code of Federal Regulations. Chapter 7 is a consolidated list of NASA regulations published in Title 14 of the Code of Federal Regulations. Complementary manuals to the NASA Management Directives System are described in Chapter 8. The second part contains an in depth alphabetical index to all NASA management directives other than handbooks, most of which are indexed by titles only.

Context-dependent impairment of recollection in list-method directed forgetting.

Science.gov (United States)

Hanczakowski, Maciej; Pasek, Tomasz; Zawadzka, Katarzyna

2012-01-01

In list-method directed forgetting, people's ability to forget one of the sets of learned material is examined. Research shows that memory for to-be-forgotten items is impaired when assessed by a recall test and by recognition tests reliant on recollective processes. Retrieval inhibition and context-change mechanisms have been proposed to account for the directed forgetting effects and both of them account for the results obtained with recognition tests. However, the context change account makes a specific prediction that recollection is impaired by directed forgetting only if it makes use of contextual associations. In the present study, directed forgetting was examined with two types of recollection-based tasks making use of different types of associations, namely a list discrimination task utilising contextual associations and an associative recognition task utilising interitem associations. Consistent with the context change account, the costs of directed forgetting were observed in a list discrimination task and were not observed in an associative recognition task. The results indicate that impairment in recollection due to directed forgetting is not general and provide converging evidence to support the context-change account.

Directed forgetting: Comparing pictures and words.

Science.gov (United States)

Quinlan, Chelsea K; Taylor, Tracy L; Fawcett, Jonathan M

2010-03-01

The authors investigated directed forgetting as a function of the stimulus type (picture, word) presented at study and test. In an item-method directed forgetting task, study items were presented 1 at a time, each followed with equal probability by an instruction to remember or forget. Participants exhibited greater yes-no recognition of remember than forget items for each of the 4 study-test conditions (picture-picture, picture-word, word-word, word-picture). However, this difference was significantly smaller when pictures were studied than when words were studied. This finding demonstrates that the magnitude of the directed forgetting effect can be reduced by high item memorability, such as when the picture superiority effect is operating. This suggests caution in using pictures at study when the goal of an experiment is to examine potential group differences in the magnitude of the directed forgetting effect. 2010 APA, all rights reserved.

A Comparison of Y-Type and T-Type Metallic Bilateral Biliary Stents in Patients with Malignant Hilar Biliary Obstruction

International Nuclear Information System (INIS)

Koh, Esther; Jin, Gong Yong; Hwang, Seung Bae; Choi, Eun Jung; Song, Ji Soo; Han, Young Min; Kwon, Keun Sang

2013-01-01

To compare the Y type (side-by-side) and T type (stent-in-stent) bilateral biliary metal stenting in malignant hilar obstruction in terms of treatment outcomes, including post-stenting serum bilirubin level and stent patency. 41 consecutive patients with advanced hilar malignancies who underwent percutaneous placement of bilateral metallic stents - Y (n = 23) and T types (n = 18) - were retrospectively reviewed. We evaluated stent patency after the procedure by cholangiogram and abdominal CT. Pre- and post-stenting serum bilirubin level (total, direct bilirubin) at 1 week and at 1 month were compared. Student t-test and Kaplan-Meier method were used in the statistical analysis. After comparing the median stent patency according to both types, they did not differ significantly (Y: 38 days, T: 61 days; p 0.141). There was a more decrease in the total and direct bilirubin of the T type compared to the Y type after 1 week (p = 0.013, 0.025). However, no significant difference existed between the decreasing bilirubin rates of both types after 1 month (p = 0.923, 0.742). In patients with malignant hilar obstruction, both Y and T type bilateral metallic biliary stents are effective methods. Stent patency and bilirubin decrease rates were not significantly different.

A Comparison of Y-Type and T-Type Metallic Bilateral Biliary Stents in Patients with Malignant Hilar Biliary Obstruction

Energy Technology Data Exchange (ETDEWEB)

Koh, Esther; Jin, Gong Yong; Hwang, Seung Bae; Choi, Eun Jung; Song, Ji Soo; Han, Young Min; Kwon, Keun Sang [Dept. of Chonbuk National University Hospital and Medical School, Jeonju (Korea, Republic of)

2013-04-15

To compare the Y type (side-by-side) and T type (stent-in-stent) bilateral biliary metal stenting in malignant hilar obstruction in terms of treatment outcomes, including post-stenting serum bilirubin level and stent patency. 41 consecutive patients with advanced hilar malignancies who underwent percutaneous placement of bilateral metallic stents - Y (n = 23) and T types (n = 18) - were retrospectively reviewed. We evaluated stent patency after the procedure by cholangiogram and abdominal CT. Pre- and post-stenting serum bilirubin level (total, direct bilirubin) at 1 week and at 1 month were compared. Student t-test and Kaplan-Meier method were used in the statistical analysis. After comparing the median stent patency according to both types, they did not differ significantly (Y: 38 days, T: 61 days; p 0.141). There was a more decrease in the total and direct bilirubin of the T type compared to the Y type after 1 week (p = 0.013, 0.025). However, no significant difference existed between the decreasing bilirubin rates of both types after 1 month (p = 0.923, 0.742). In patients with malignant hilar obstruction, both Y and T type bilateral metallic biliary stents are effective methods. Stent patency and bilirubin decrease rates were not significantly different.

The Direct Methanol Liquid-Feed Fuel Cell

Science.gov (United States)

Halpert, Gerald

1997-01-01

Until the early 1990's the idea of a practical direct methanol fuel cell from transportation and other applications was just that, an idea. Several types of fuel cells that operate under near ambient conditions were under development.

Metabolite ratios as potential biomarkers for type 2 diabetes : a DIRECT study

NARCIS (Netherlands)

Molnos, Sophie; Wahl, Simone; Haid, Mark; Eekhoff, E Marelise W; Pool, René; Floegel, Anna; Deelen, Joris; Much, Daniela; Prehn, Cornelia; Breier, Michaela; Draisma, Harmen H; van Leeuwen, Nienke; Simonis-Bik, Annemarie M C; Jonsson, Anna; Willemsen, Gonneke; Bernigau, Wolfgang; Wang-Sattler, Rui; Suhre, Karsten; Peters, Annette; Thorand, Barbara; Herder, Christian; Rathmann, Wolfgang; Roden, Michael; Gieger, Christian; Kramer, Mark H H; van Heemst, Diana; Pedersen, Helle K; Gudmundsdottir, Valborg; Schulze, Matthias B; Pischon, Tobias; de Geus, Eco J C; Boeing, Heiner; Boomsma, Dorret I; Ziegler, Anette G; Slagboom, P. Eline; Hummel, Sandra; Beekman, Marian; Grallert, Harald; Brunak, Søren; McCarthy, Mark I; Gupta, Ramneek; Pearson, Ewan R; Adamski, Jerzy; 't Hart, Leen M

2018-01-01

AIMS/HYPOTHESIS: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and

Sensing of substratum rigidity and directional migration by fast-crawling cells

Science.gov (United States)

Okimura, Chika; Sakumura, Yuichi; Shimabukuro, Katsuya; Iwadate, Yoshiaki

2018-05-01

Living cells sense the mechanical properties of their surrounding environment and respond accordingly. Crawling cells detect the rigidity of their substratum and migrate in certain directions. They can be classified into two categories: slow-moving and fast-moving cell types. Slow-moving cell types, such as fibroblasts, smooth muscle cells, mesenchymal stem cells, etc., move toward rigid areas on the substratum in response to a rigidity gradient. However, there is not much information on rigidity sensing in fast-moving cell types whose size is ˜10 μ m and migration velocity is ˜10 μ m /min . In this study, we used both isotropic substrata with different rigidities and an anisotropic substratum that is rigid on the x axis but soft on the y axis to demonstrate rigidity sensing by fast-moving Dictyostelium cells and neutrophil-like differentiated HL-60 cells. Dictyostelium cells exerted larger traction forces on a more rigid isotropic substratum. Dictyostelium cells and HL-60 cells migrated in the "soft" direction on the anisotropic substratum, although myosin II-null Dictyostelium cells migrated in random directions, indicating that rigidity sensing of fast-moving cell types differs from that of slow types and is induced by a myosin II-related process.

A Simple Solution to Type Specialization

DEFF Research Database (Denmark)

Danvy, Olivier

1998-01-01

Partial evaluation specializes terms, but traditionally this specialization does not apply to the type of these terms. As a result, specializing, e.g., an interpreter written in a typed language, which requires a “universal” type to encode expressible values, yields residual programs with type tags...... all over. Neil Jones has stated that getting rid of these type tags was an open problem, despite possible solutions such as Torben Mogensen's “constructor specialization.” To solve this problem, John Hughes has proposed a new paradigm for partial evaluation, “Type Specialization”, based on type...... inference instead of being based on symbolic interpretation. Type Specialization is very elegant in principle but it also appears non-trivial in practice. Stating the problem in terms of types instead of in terms of type encodings suggests a very simple type-directed solution, namely, to use a projection...

Method for the determination of natural ester-type gum bases used as food additives via direct analysis of their constituent wax esters using high-temperature GC/MS.

Science.gov (United States)

Tada, Atsuko; Ishizuki, Kyoko; Yamazaki, Takeshi; Sugimoto, Naoki; Akiyama, Hiroshi

2014-07-01

Natural ester-type gum bases, which are used worldwide as food additives, mainly consist of wax esters composed of long-chain fatty acids and long-chain fatty alcohols. There are many varieties of ester-type gum bases, and thus a useful method for their discrimination is needed in order to establish official specifications and manage their quality control. Herein is reported a rapid and simple method for the analysis of different ester-type gum bases used as food additives by high-temperature gas chromatography/mass spectrometry (GC/MS). With this method, the constituent wax esters in ester-type gum bases can be detected without hydrolysis and derivatization. The method was applied to the determination of 10 types of gum bases, including beeswax, carnauba wax, lanolin, and jojoba wax, and it was demonstrated that the gum bases derived from identical origins have specific and characteristic total ion chromatogram (TIC) patterns and ester compositions. Food additive gum bases were thus distinguished from one another based on their TIC patterns and then more clearly discriminated using simultaneous monitoring of the fragment ions corresponding to the fatty acid moieties of the individual molecular species of the wax esters. This direct high-temperature GC/MS method was shown to be very useful for the rapid and simple discrimination of varieties of ester-type gum bases used as food additives.

Method for the determination of natural ester-type gum bases used as food additives via direct analysis of their constituent wax esters using high-temperature GC/MS

Science.gov (United States)

Tada, Atsuko; Ishizuki, Kyoko; Yamazaki, Takeshi; Sugimoto, Naoki; Akiyama, Hiroshi

2014-01-01

Natural ester-type gum bases, which are used worldwide as food additives, mainly consist of wax esters composed of long-chain fatty acids and long-chain fatty alcohols. There are many varieties of ester-type gum bases, and thus a useful method for their discrimination is needed in order to establish official specifications and manage their quality control. Herein is reported a rapid and simple method for the analysis of different ester-type gum bases used as food additives by high-temperature gas chromatography/mass spectrometry (GC/MS). With this method, the constituent wax esters in ester-type gum bases can be detected without hydrolysis and derivatization. The method was applied to the determination of 10 types of gum bases, including beeswax, carnauba wax, lanolin, and jojoba wax, and it was demonstrated that the gum bases derived from identical origins have specific and characteristic total ion chromatogram (TIC) patterns and ester compositions. Food additive gum bases were thus distinguished from one another based on their TIC patterns and then more clearly discriminated using simultaneous monitoring of the fragment ions corresponding to the fatty acid moieties of the individual molecular species of the wax esters. This direct high-temperature GC/MS method was shown to be very useful for the rapid and simple discrimination of varieties of ester-type gum bases used as food additives. PMID:25473499

Yields of base damage products in crystalline DNA produced by the direct-type effect

International Nuclear Information System (INIS)

Gilbert, D.C.; Bernhard, W.A.; Swarts, S.G.

2003-01-01

Our aim is to determine the yields of base damage products due to direct-type effects in well-defined DNA samples. The sample, crystalline d(GCACGCGTGC) 2 , which contains Co(III), has been structurally characterized by others using X-ray crystallography and the free radical yields measured by our laboratory using EPR spectroscopy. Polycrystalline samples were x-irradiated (70 KeV) at room temperature (RT) to doses up to 150 kGy. Following dissolution under air, the base products were identified and quantified using GC-MS. 7,8-dihydro-8-oxoguanine (8-oxo-G) is the primary base damage product found, with a yield of ∼0.09 μmoles/J, whereas 2,6-diamino-4-oxo-5-formamidopyrimidine (FpyG) was below the limits of detection of the GC-MS assay. Radiation yields for 5,6-dihydrothymine (DHT) and 5-hydroxymethyluracil of 0.0017 and 0.0042 μmoles/J, respectively, were also observed. These results differ from those obtained in a previous study of solid-state hydrated DNA irradiated at RT (Swarts et al., Radiat. Res. 145: 304-14, 1996), where the yields of FpyG and DHT were approximately 11% and 20% that of 8-oxo-G, respectively. Our working hypothesis is that Co(III) in crystalline d(GCACGCGTGC) 2 modifies the product distribution. Based on the EPR data, the influence of Co(III) on the initial distribution of radical trapping is negligible. This suggests that electron transfer from the pyrimidines to Co(III) occurs either upon annealing and/or upon solvation, thereby competing with dihydropyrimidine formation. While strand break (sb) yields for d(GCACGCGTGC) 2 are not yet completed, in earlier work on crystals of other oligomers, we obtained sb yields of 0.06-0.16 μmoles/J. We anticipate, therefore, that the stoichiometry between 8-oxo-G and sb formation will be about 1:1

On the nature and properties of appeals used in direct-to-consumer advertising of prescription drugs.

Science.gov (United States)

Pinto, M B

2000-04-01

The past decade has seen a steady rise in expenditures for direct-to-consumer pharmaceutical advertising. While total revenues across all media are approaching the $1 billion dollar mark, surprisingly little is known about the effectiveness of these types of advertisements, including the appropriateness of various forms of emotional and informational appeal. A content analysis of direct-to-consumer advertising in 24 popular magazines shows that these advertisements are found in every category of magazine, the advertisements employ a mix of informational and emotional appeals, all types of emotional appeals are used, and to date, the type of appeal (emotional and/or informational) tends not to be based on the type of drug advertised. Implications of this content analysis are considered and directions for research on appeals used in direct-to-consumer advertising are suggested.

Direct plasma interaction with living tissue

Science.gov (United States)

Fridman, Gregory

For some time, plasma has been used in medicine to cauterize or cut tissue using heat and mechanical energy. In the recent decade, some researchers around the world have started to investigate how gas jets that pass through thermal plasma can be employed in medicine. This thesis presents the first investigation of biomedical uses of non-thermal plasma discharge which comes in direct contact with living tissue. It is demonstrated that the direct application of non-thermal plasma in air can cause rapid deactivation of bacteria on surfaces of tissues without causing any visible tissue damage. Medical need for such a device is discussed. Construction and operation of various types of non-thermal plasma power supplies and many types of treatment electrodes are presented as well. Application of this plasma to living organisms is shown to be safe from both the electrical perspective and from the biological perspective. Biological safety is revealed through a series of differential skin toxicity trials on human cadaver tissue, live hairless mouse skin tissue, live pig skin tissue, and finally in an open wound model on pigs. Direct non-thermal plasma in air is shown to deactivate bacteria about 100 times faster than indirect application using jets. A series of experiments reveal that this effectiveness is due to the ability of direct discharge to bring charges to tissue surfaces. It is demonstrated that neither ultraviolet (UV) radiation nor neutral active species such as hydroxyl radicals or ozone produced in plasma are responsible for the main effect on bacteria. Although much additional work remains on establishing detailed mechanism by which charges from plasma achieve this effect, the work carried out in this thesis clearly demonstrates that direct application of non-thermal plasma in air can be a very useful tool in medicine.

High direct costs of medical care in patients with Type 1 diabetes attending a referral clinic in a government-funded hospital in Northern India.

Science.gov (United States)

Katam, Kishore K; Bhatia, Vijayalakshmi; Dabadghao, Preeti; Bhatia, Eesh

2016-01-01

There is little information regarding costs of managing type 1 diabetes mellitus (T1DM) from low- and middle-income countries. We estimated direct costs of T1DM in patients attending a referral diabetes clinic in a governmentfunded hospital in northern India. We prospectively enrolled 88 consecutive T1DM patients (mean [SD] age 15.3 [8] years) with age at onset clinic of our institution. Data on direct costs were collected for a 12 months-6 months retrospectively followed by 6 months prospectively. Patients belonged predominantly (77%) to the middle socioeconomic strata (SES); 81% had no access to government subsidy or health insurance. The mean direct cost per patient-year of T1DM was `27 915 (inter-quartile range [IQR] `19 852-32 856), which was 18.6% (7.1%-30.1%) of the total family income. A greater proportion of income was spent by families of lower compared to middle SES (32.6% v. 6.6%, p<0.001). The mean out-of-pocket payment for diabetes care ranged from 2% to 100% (mean 87%) of the total costs. The largest expenditure was on home blood glucose monitoring (40%) and insulin (39.5%). On multivariate analysis, total direct cost was associated with annual family income (β=0.223, p=0.033), frequency of home blood glucose monitoring (β=0.249, p=0.016) and use of analogue insulin (β=0.225, p=0.016). Direct costs of T1DM were high; in proportion to their income the costs were greater in the lower SES. The largest expenditure was on home blood glucose monitoring and insulin. Support for insulin and glucose testing strips for T1DM care is urgently required.

Directed self-avoiding walks in random media

International Nuclear Information System (INIS)

Santra, S. B.; Seitz, W. A.; Klein, D. J.

2001-01-01

Two types of directed self-avoiding walks (SAW's), namely, three-choice directed SAW and outwardly directed SAW, have been studied on infinite percolation clusters on the square lattice in two dimensions. The walks on the percolation clusters are generated via a Monte Carlo technique. The longitudinal extension R N and the transverse fluctuation W N have been measured as a function of the number of steps N. Slight swelling is observed in the longitudinal direction on the random lattices. A crossover from shrinking to swelling of the transverse fluctuations is found at a certain length N c of the walks. The exponents related to the transverse fluctuations are seen to be unchanged in the random media even as the percolation threshold is reached. The scaling function form of the extensions are verified

Laser direct joining of metal and plastic

International Nuclear Information System (INIS)

Katayama, Seiji; Kawahito, Yousuke

2008-01-01

We have developed an innovative rapid laser direct joining process of metal and plastic lap plates without adhesives or glues. The joints made between a Type 304 stainless steel plate and a polyethylene terephthalate (PET) plastic sheet of 30 mm width possessed tensile shear loads of about 3000 N. Transmission electron microscope photographs of the joint demonstrated that Type 304 and the PET were bonded on the atomic, molecular or nanostructural level through a Cr oxide film

Wood construction and magnetic characteristics of impregnated type magnetic wood

International Nuclear Information System (INIS)

Oka, Hideo; Hojo, Atsushi; Seki, Kyoushiro; Takashiba, Toshio

2002-01-01

The results of experiments involving the AC and DC magnetic characteristics of impregnated type magnetic wood were studied by taking into consideration the wood construction and fiber direction. The experimental results show that the sufficient amount of impregnated magnetic fluid varies depending on the fiber direction and length, and the grain face of the wood material. The impregnated type magnetic wood sample that is fully impregnated by magnetic fluid has a 60% saturation magnetization compared to the saturation magnetization of magnetic fluid. Samples for which the wood fiber direction was the same as the direction of the magnetic path had a higher magnetization intensity and permeability

Investigation of bending fatigue-life of aluminum sheets based on rolling direction

Directory of Open Access Journals (Sweden)

Raif Sakin

2018-03-01

Full Text Available High-cycle fatigue (HCF and low-cycle fatigue (LCF fatigue lives of rolled AA1100 and AA1050 aluminum sheets along different directions were evaluated at room temperature. Four types of samples denoted as longitudinal (L and transverse (T to the rolling direction were compared because the samples along the two typical directions show an obvious anisotropy. A cantilever plane-bending and multi-type fatigue testing machine was specially designed for this purpose. Deflection-controlled fatigue tests were conducted under fully reversed loading. The longest fatigue lives in the LCF region were obtained for AA1050 (L while AA1100 (L samples had the longest fatigue lives in the HCF region. Keywords: AA1100, AA1050, Aluminum sheet, Bending fatigue life, Rolling direction

The relationship between work-family conflict and central life interests amongst single working mothers

Directory of Open Access Journals (Sweden)

Taryn Wallis

2003-10-01

Full Text Available This study explored the experiences of work-family conflict amongst a group of twenty single working mothers with pre-school age children. Dubin’s (1992 theory of Central Life Interests was utilised to fully understand how the differential importance of the roles played by the women informed the level and nature of the conflict experienced. A two-phase research design was employed in which questionnaire responses from the first phase formed the basis for the second phase of in-depth qualitative interviews. Results indicated that participants viewed motherhood as their Central Life Interest and that this priority could lead them to experience greater conflict between work and family demands. Although work was rated second in importance when compared to family, it was still seen as being of great significance, not only for instrumental reasons, but also for the intellectual stimulation that it provided and opportunities to exercise independence and responsibility. Opsomming Die werk-en-familie konflik-ervarings van twintig werkende enkel-moeders met voorskoolse kinders is ondersoek in hierdie projek. Dubin (1992 se teorie van sentrale lewensbelangstellings is gebruik om te bepaal hoe die belangrikheid van die twee rolle die vlak en aard van die konflik bepaal het. Die navorsing is in twee fases gedoen: ‘n vraelys in die eerste fase, opgevolg deur in-diepte kwalitatiewe onderhoude. Resultate het gewys dat die deelnemers moederskap as hul sentrale lewensbelangstelling beskou het, en dat hierdie prioriteit kon lei tot groter konflik tussen die eise van werk en familie. Alhoewel werk as ondergeskik aan familie beoordeel is, was dit nogtans van groot belang. Aan die een kant was dit vir instrumentele redes, maar dit het ook intellektuele stimulasie verskaf en geleenthede gegee om onafhanklik en verantwoordelik op te tree.

Van die Gasredakteur

African Journals Online (AJOL)

cherish and teach.'1. Die Fakulteit Geneeskunde van die Universiteit van die Oranje-Vrystaat het pragtig gegroei ge- durende die eerste 21 jaar van sy bestaan. Die entoesiasme, doelgerigtheid, harde werk en inisia- tiewe van 'n groot aantal persone was hiervoor verantwoordelik. 'If we see a bit more clearly than they, it is ...

Suid-Afrikaanse romans in Afrikaans sowel as Engels; soms bloot ...

African Journals Online (AJOL)

8 Apr 2016 ... word in sommige van die collages wat elke hoofstuk voorafgaan. Benewens die gesprek met ouer, meer literêre werke, kan Botha se roman ook andersyds beskou word as deel van 'n bepaalde kontemporêre literêre beweging, waar- êre literêre beweging, waar- re literêre beweging, waar- êre beweging ...

Options of ship discharge

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-05-15

Environmental performance is a key design consideration for manufacturers of bulk handling machines, not least ship unloaders, with features being introduced to minimise dust and noise pollution. The article reports on developments in grab unloaders, slewing grabcranes and mobile grabcranes by manufacturers such as Konecrane, EMS-Tech, Liebherr-Werk Nenzing and Gottwald. 2 photos.

Valued Estonian Music CDs

Index Scriptorium Estoniae

2004-01-01

2002. aastal välja antud eesti muusika heliplaatidest Artur Kapp "Symphonische Werke", Eduard Tubin "Symphonies No.9, No.10 and No.11", "Estonian Preludes", "Eesti heliloojad. Hortus Musicus", "Eesti Muusika Päevad", "Tallinn Saxophone Quartet. Estonian Contemporary Music", "Triskele. Kolga-Jaani vaimulikud rahvalaulud", "Helmekaala. Linnupuu Anne", "Modern Fox mängib Raimond Valgret",

Prantsuse maastikuarhitektid Berliinist = French Landscape Architects from Berlin / Katrin Koov

Index Scriptorium Estoniae

Koov, Katrin, 1973-

2003-01-01

Berliinis töötavad prantsuse maastikuarhitektid Veronique Faucheur, Marc Pouzol ja Laurent Dugua büroost le balto kujundavad Tallinnasse "Heliose" kino hoovi valgusaia. Valminud on projekti I etapp, aed valmib 2004. a. kevadeks. Arhitektide loomingust (projekt "Ajutised Aiad" ja Kunst-Werke aed Berliinis, Palais de Tokyo aed Pariisis, Padula kloostri aed Itaalias)

15 Resensie Fourie 03 WEB.pmd

African Journals Online (AJOL)

Owner

regverdige kans te gee en die gaping in die resepsie van sy werk te vul. Teen hierdie agtergrond en die doelstelling van die versameling moet dit egter gestel word dat die mederedakteurskap van Brink se eggenote Szczurek 'n mens ietwat onge- maklik laat voel––juis omdat die bundel uitdruklik ingaan teen die ingeteelde ...

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African Journals Online (AJOL)

Items 51 - 100 of 317 ... Vol 4, No 4 (2010), Diffuse bony involvement in disseminated BCG disease in a patient with possible severe combined immune deficiency (SCID), Abstract PDF. N Khan, I van de Werke, F Ismail. Vol 7, No 3 (2013), Dilemmas of telling bad news: Paediatric palliative care providers' experiences in rural ...

D r . A. S iz oo , Christenen in die Antieke Wereld, JH Kok, Kampen ...

African Journals Online (AJOL)

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Aan die hand van 'n aantal sketse wat deeglik gefundeer is in die oud-christelike bronnemateriaal, bied hierdie bekende skrywer 'n blik in die alledaagse lewe van die vroeë Christendom. Hoewel populêr geskrywe en maklik verstaanbaar vir die nie-teoloog, is die werk in die gebruik van sy bronne en sy gevolgtrekkinge ...

DIE ROL VAN DIE TAALWETENSKAP IN DIE ONTWIKKELING VAN ...

African Journals Online (AJOL)

aanslag op die sogenaamde "Intentional Fallacy", heelwat verder. n. Mens sou hier eintlik ook op die invloed van Lacan se toepassing van. De Sacs sure op Freud moet wys, en op Macherey se Theory of Literary. Production. Barthes is naamlik besig om repressie teen te werk, en die teks as produksieproses in stede van ...

A. S. G O. C ullmann , Der Staat im Neuen Testament. J. C . B. Mohr ...

African Journals Online (AJOL)

Test

Dit is nietemin nie die eerste maal dat Cullmann oor die onderwerp skryf nie. Vroeër het daar reeds van hom verskyn, Konigsherrschaft. Christ und Kirche im Neuen Testament, en effens later, Die ersten christliche. Qlaubensbekenntnisse en betreklik onlangs, Christus und die Zeit. In al hierdie werke raak hy fasette van die ...

The relation between the kink-type solution and the kink-bell-type solution of nonlinear evolution equations

International Nuclear Information System (INIS)

Liu Chunping

2003-01-01

Using a direct algebraic method, more new exact solutions of the Kolmogorov-Petrovskii-Piskunov equation are presented by formula form. Then a theorem concerning the relation between the kink-type solution and the kink-bell-type solution of nonlinear evolution equations is given. Finally, the applications of the theorem to several well-known equations in physics are also discussed

How should we deal with ethics in student supervision?

Directory of Open Access Journals (Sweden)

Ellen Hooyberghs

2012-06-01

Dat supervisie essentieel is binnen het beroep van sociaal werk, daar zijn sociaal werkers het al langer over eens. Supervisie krijgt binnen de opleiding sociaal werk dan ook een belangrijke plaats. In supervisie leren studenten (eerste werkervaringen te analyseren, eigen indrukken en gevoelens te onderzoeken en hun visie op het werkveld te verruimen en dit onder begeleiding van een supervisor. Studenten leren tevens de reeds verworven theorie om te zetten in de praktijk. Voor het merendeel van de studenten is dit geen eenvoudige klus. Zij hebben dan vele morele en ethische vragen over hun handelen. Aangezien de waarden en normen binnen het sociaal werkveld niet statisch en eenduidig zijn, is het soms ook erg verwarrend wat nu juist “juist” handelen is. Binnen een supervisiegroep kunnen hier bij de verschillende studenten en supervisor meerdere meningen over bestaan. Daarom wordt de methodiek “Ethische cirkels in sociaal werk” toegelicht in dit artikel. Deze methode kan een houvast bieden voor studenten en supervisor om aan de slag te gaan met ethische vragen.

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment

International Nuclear Information System (INIS)

Schedlbauer, Andreas; Auer, Renate; Ledolter, Karin; Tollinger, Martin; Kloiber, Karin; Lichtenecker, Roman; Ruedisser, Simon; Hommel, Ulrich; Schmid, Walther; Konrat, Robert; Kontaxis, Georg

2008-01-01

Direct methods in NMR based structure determination start from an unassigned ensemble of unconnected gaseous hydrogen atoms. Under favorable conditions they can produce low resolution structures of proteins. Usually a prohibitively large number of NOEs is required, to solve a protein structure ab-initio, but even with a much smaller set of distance restraints low resolution models can be obtained which resemble a protein fold. One problem is that at such low resolution and in the absence of a force field it is impossible to distinguish the correct protein fold from its mirror image. In a hybrid approach these ambiguous models have the potential to aid in the process of sequential backbone chemical shift assignment when 13 C β and 13 C' shifts are not available for sensitivity reasons. Regardless of the overall fold they enhance the information content of the NOE spectra. These, combined with residue specific labeling and minimal triple-resonance data using 13 C α connectivity can provide almost complete sequential assignment. Strategies for residue type specific labeling with customized isotope labeling patterns are of great advantage in this context. Furthermore, this approach is to some extent error-tolerant with respect to data incompleteness, limited precision of the peak picking, and structural errors caused by misassignment of NOEs

Study of Knowledge and Practice of Patient Self directed Care among Diabetics Patients

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Z. Abedini

2008-07-01

Full Text Available Background and ObjectivesDiabetic patients play the main role in the management of their disease. Adequate knowledge of this disease state and self directed patient care will improve the health of these patients. Some studies have indicated a high prevalence of diabetes complication are due to the lack of knowledge of self directed patient care and practice in diabetic patient group. The objective of this study is to measure the knowledge level of self directed patient care and practice in order to evaluate their effects on improvement of diabetic patients' health in the city of Qom, Iran.MethodsIn this cross sectional study 1004 patients with diabetes participated (During year 2006. Data were collected from patients of General Hospital metabolism and endocrine research center.An interviewing method was used to asses the demographics data, history of disease, and knowledge of self directed patient care in these patients. Data were analyzed using a descriptive statistic, chi-square, and Pearson correlation coefficient, and SPSS software.ResultsOut of 1004 observed case, 154 patients were with Diabetes type I and 850 patients with Diabetes type II. The knowledge of self directed patient care and practice level of with both types of diabetes were determined to be mostly at an intermediate level. In type I diabetic patients there was a significant relation between knowledge level of self directed patient care and gender of the patients (P=0.01. Also, there was a significant correlation between practice and age (P=0.03(, and economical status (P=0.06 of the patients. In type II diabetic patients there was a significant relation between knowledge level of self directed patient care and educational level (P=0.00(, and economical status (P=0.01 of the patients. The practice level of self directed patient care was significantly related to economical status (p=0.03 in this group of patients. ConclusionThese results indicate that an increase in knowledge

Multi-directional random wave interaction with an array of cylinders

DEFF Research Database (Denmark)

Ji, Xinran; Liu, Shuxue; Bingham, Harry B.

2015-01-01

Based on the linear theory of wave interaction with an array of circular bottom-mounted vertical cylinders, systematic calculations are made to investigate the effects of the wave directionality on wave loads in short-crested seas. The multi-directional waves are specified using a discrete form...... of the Mitsuyasu-type spreading function. The time series of multi-directional wave loads, including both the wave run-up and wave force, can be simulated. The effect of wave directionality on the wave run-up and wave loading on the cylinders is investigated. For multi-directional waves, as the distribution...

Immunological properties of inulin-type fructans.

Science.gov (United States)

Vogt, Leonie; Meyer, Diederick; Pullens, Gerdie; Faas, Marijke; Smelt, Maaike; Venema, Koen; Ramasamy, Uttara; Schols, Henk A; De Vos, Paul

2015-01-01

Beneficial effects of inulin-type fructans are discussed in view of studies that applied the oligosaccharides in colon cancer, chronic inflammatory diseases, vaccination efficacy, and prevention of infection and allergy. In the present paper, we discuss their immunomodulating effects. It is suggested that immunomodulation is elicited through indirect and direct mechanisms. Indirect mechanisms encompass stimulation of growth and activity of lactic acid bacteria, but can also be caused by fermentation products of these bacteria, i.e., short chain fatty acids. Evidence for direct effects on the immune system generally remains to be confirmed. It is suggested that inulin-type fructans can be detected by gut dendritic cells (DCs), through receptor ligation of pathogen recognition receptors (PRRs) such as Toll-like receptors, nucleotide oligomerization domain containing proteins (NODs), C-type lectin receptors, and galectins, eventually inducing pro- and anti-inflammatory cytokines. DCs may also exert antigen presenting capacity toward effector cells, such as B cells, T cells, and natural killer cells locally, or in the spleen. Inulin-type fructans may also ligate PRRs expressed on gut epithelium, which could influence its barrier function. Inulin-type fructans are potent immunomodulating food components that hold many promises for prevention of disease. However, more studies into the mechanisms, dose-effect relations, and structure-function studies are required.

Disordered Eating in Girls with Type 1 Diabetes: Examining Directions for Prevention

Science.gov (United States)

Starkey, Karina; Wade, Tracey

2010-01-01

Girls with Type 1 diabetes (insulin-dependent diabetes mellitus [IDDM]) have been identified to be at an increased risk for developing bulimia nervosa (BN) and subthreshold eating disorders. The co-occurrence of these conditions can severely compromise the physical health of these individuals and can even accelerate mortality. The use of a unique…

Successful treatment of direct carotid-cavernous fistula in a patient with Ehlers-Danlos syndrome type IV without arterial puncture: the transvenous triple-overlay embolization (TAILOREd) technique.

Science.gov (United States)

Huynh, Thien J; Morton, Ryan P; Levitt, Michael R; Ghodke, Basavaraj V; Wink, Onno; Hallam, Danial K

2017-08-18

We report successful transvenous treatment of direct carotid-cavernous fistula in a patient with Ehlers-Danlos syndrome type IV using a novel triple-overlay embolization (TAILOREd) technique without the need for arterial puncture, which is known to be highly risky in this patient group. The TAILOREd technique allowed for successful treatment using preoperative MR angiography as a three-dimensional overlay roadmap combined with cone beam CT and live fluoroscopy, precluding the need for an arterial puncture. 2017 BMJ Publishing Group Ltd.

Weather types in the South Shetlands (Antarctica) using a circulation type approach

Science.gov (United States)

Mora, Carla; João Rocha, Maria; Dutra, Emanuel; Trigo, Isabel; Vieira, Gonçalo; Fragoso, Marcelo; Ramos, Miguel

2010-05-01

Weather types in the South Shetlands (Antarctica) were defined using an automated method based on the Lamb Weather Type classification scheme (Jones et al. 1993). This is an objective classification originally developed for the British Isles (Jones et al., 1993) and also applied to southeast (Goodess and Palutikof 1998) and northwest Spain (Lorenzo et al, 2009), Portugal (Trigo and DaCamara 2000) and Greece (Maheras et al. 2004) with good results. Daily atmospheric circulation in the South Shetlands region from 1989 to 2009 was classified using a 16-node grid of sea level pressure data from the ERA Interim. The classification is obtained through the comparison of the magnitudes of the directional and rotational components of the geostrophic flow. Basic circulation types were combined into 10 groups of weather types: four directional types (NW, N, S and SW), three anticyclonic types (A, ASW and ANW), and three cyclonic types (C, CSW and CNW). Westerly flow and cyclonic circulation are the most frequent events throughout the year. The sea level pressure field for each weather type is presented and the synoptic characteristics are described. The analysis is based on ERA-Interim fields, including mean sea level pressure, precipitation, cloud cover, humidity and air temperature. Snow thickess modelled using HTESSEL is also considered. Analysis of variance (anova) and multivariate analysis (principal component analysis) are applied to evaluate the characteristics of each weather type. This circulation-type approach showed good results in the past for the downscaling of precipitation in other regions, and we are interested in evaluating the possibilities that the classification offers for downscaling precipitation, but also for snow and air temperature. For this we will be using observational data at test sites in Livingston and Deception islands. We are also motivated by the possibility of using the circulation-type approach as a predictor in statistical downscaling

The Influence of Direct and Indirect Speech on Source Memory

Directory of Open Access Journals (Sweden)

Anita Eerland

2018-02-01

Full Text Available People perceive the same situation described in direct speech (e.g., John said, “I like the food at this restaurant” as more vivid and perceptually engaging than described in indirect speech (e.g., John said that he likes the food at the restaurant. So, if direct speech enhances the perception of vividness relative to indirect speech, what are the effects of using indirect speech? In four experiments, we examined whether the use of direct and indirect speech influences the comprehender’s memory for the identity of the speaker. Participants read a direct or an indirect speech version of a story and then addressed statements to one of the four protagonists of the story in a memory task. We found better source memory at the level of protagonist gender after indirect than direct speech (Exp. 1–3. When the story was rewritten to make the protagonists more distinctive, we also found an effect of speech type on source memory at the level of the individual, with better memory after indirect than direct speech (Exp. 3–4. Memory for the content of the story, however, was not influenced by speech type (Exp. 4. While previous research showed that direct speech may enhance memory for how something was said, we conclude that indirect speech enhances memory for who said what.

Moderating Effects of Sales Promotion Types

Directory of Open Access Journals (Sweden)

Fernando de Oliveira Santini

2015-04-01

Full Text Available This paper aims to analyze the influence sales promotion types have on the relationship between perception of financial risk and perception of utilitarian and hedonic value on consumer purchase intentions. To this end, an experiment was conducted involving 589 participants divided into two groups defined by distinct scenarios in which the sales promotion type (monetary vs. non-monetary was manipulated. The working hypotheses predicted a direct and positive relationship between the perception of (hedonic and utilitarian consumption value and purchase intention for a promoted product and a negative relationship between the perception of consumption value and the perception of financial risk. In addition, it was supposed that the sales promotion type would moderate these direct relationships and that a monetary promotion would have a stronger effect on the relationship between purchase intention and perceived product utility, whereas a non-monetary promotion would have a stronger effect on the other relationships (hedonic value and financial risk perceptions. Analysis of the outcomes supported the proposed hypotheses.

Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography.

Science.gov (United States)

Shen, T; Morlock, G; Zorn, H

2015-01-01

Fungi of the phylum Basidiomycota are well-known to form a broad spectrum of biologically active secondary metabolites, especially low molecular weight compounds such as terpenoids. Hericium erinaceus produces various cyathane type diterpenoids including erinacines. However, no quantitative data and production kinetics have been reported on the biosynthesis of the erinacines C and P in submerged cultures. In the present study, the production of erinacine C was optimized, and the product formation kinetics as well as the antimicrobial activity were studied by high-performance liquid chromatography (HPLC), high-performance thin-layer chromatography (HPTLC) and direct bioautography. Oatmeal and Edamin ® K were identified to be crucial media components for an efficient production of erinacine C. The highest concentrations of erinacine C were obtained in the optimized culture medium on the 9 th culture day (approximately 260 mg L -1 ). The production of erinacine P was strongly time dependent. The maximum concentration of erinacine P of 184 mg L -1 was observed on the third culture day. Afterwards, the concentrations of erinacine P decreased while the concentrations of erinacine C steadily increased. Comparable results were obtained by HPTLC with UV detection and HPLC with diode-array detection (DAD) analyses. Direct bioautography allowed for an additional analysis of the antimicrobial activity of the secondary metabolites. The C and N sources oatmeal and Edamin ® K induced the formation of erinacine C. Detailed product formation kinetics of the erinacines C and P have been reported for the first time. HPTLC combined with the Aliivibrio fischeri bioassay allowed for an instant detection of cyathane diterpenoids in crude extracts and for an evaluation of the antimicrobial activity of the secondary metabolites directly on the plate.

Corporate income taxation uncertainty and foreign direct investment

OpenAIRE

Zagler, Martin; Zanzottera, Cristiana

2012-01-01

This paper analyzes the effects of legal uncertainty around corporate income taxation on foreign direct investment (FDI). Legal uncertainty can take many forms: double tax agreements, different types of legal systems and corruption. We test the effect of legal uncertainty on foreign direct investment with an international panel. We find that an increase in the ratio of the statutory corporate income tax rate of the destination relative to the source country exhibits a negati...

Direct fluorination? Useful tool to enhance commercial properties of polymer articles

NARCIS (Netherlands)

Kharitonov, A.P.; Taege, R.; Ferrier, G.; Teplyakov, V.V.; Syrtsova, D.A.; Syrtsova, D.A.; Koops, G.H.

2005-01-01

Fundamental features and industrial applications of the direct fluorination of polymers are reviewed. Fundamental features of the direct fluorination of a set of polymers, such as polystyrene, polyethyleneterephthalate, poly(2,6-dimethyl-1,4-phenylene oxide), PMMA, LDPE (two types), HDPE (six

Tobacco industry marketing: an analysis of direct mail coupons and giveaways.

Science.gov (United States)

Brock, Betsy; Schillo, Barbara A; Moilanen, Molly

2015-09-01

Despite marketing prohibitions, tobacco company marketing expenditures in the USA have continued to grow with tobacco companies shifting focus towards point-of-sale-marketing and direct marketing to consumers through the mail and on the web. The purpose of this observational study was to investigate the content of direct marketing sent in response to registrations on select industry websites. An analysis of 659 tobacco company direct mail marketing pieces received between July 2011 and June 2012 was conducted. Mailings were coded for type and value of tobacco coupons, type of tobacco products promoted with coupons and number and type of giveaways offered. The most common type of mailing was tobacco coupon distribution; 86.5% of the mailings contained at least one coupon. Mailings with coupons had an average estimated coupon value of $4.17. The total coupon value of each mailing varied by the type of coupon offer and product promoted. The Camel and Marlboro coupon mailings heavily promoted snus, with over half of Camel coupon mailings (60.9%) and nearly half (44.8%) of Marlboro coupon mailings promoting snus alone. In addition, 47.9% of Marlboro coupon mailings and 11.4% of Camel mailings promoted snus alongside cigarettes. Tobacco companies use direct mail marketing to communicate with consumers and provide valuable tobacco coupons. More research is needed to understand the content of these mailings and how they are used by tobacco consumers in order to develop effective policy solutions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Interspike Interval Based Filtering of Directional Selective Retinal Ganglion Cells Spike Trains

Directory of Open Access Journals (Sweden)

Aurel Vasile Martiniuc

2012-01-01

Full Text Available The information regarding visual stimulus is encoded in spike trains at the output of retina by retinal ganglion cells (RGCs. Among these, the directional selective cells (DSRGC are signaling the direction of stimulus motion. DSRGCs' spike trains show accentuated periods of short interspike intervals (ISIs framed by periods of isolated spikes. Here we use two types of visual stimulus, white noise and drifting bars, and show that short ISI spikes of DSRGCs spike trains are more often correlated to their preferred stimulus feature (that is, the direction of stimulus motion and carry more information than longer ISI spikes. Firstly, our results show that correlation between stimulus and recorded neuronal response is best at short ISI spiking activity and decrease as ISI becomes larger. We then used grating bars stimulus and found that as ISI becomes shorter the directional selectivity is better and information rates are higher. Interestingly, for the less encountered type of DSRGC, known as ON-DSRGC, short ISI distribution and information rates revealed consistent differences when compared with the other directional selective cell type, the ON-OFF DSRGC. However, these findings suggest that ISI-based temporal filtering integrates a mechanism for visual information processing at the output of retina toward higher stages within early visual system.

Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I.

Science.gov (United States)

Huang, Y; Ohtani, K; Iwanaga, R; Matsumura, Y; Nakamura, M

2001-03-01

Cyclins are one of the pivotal determinants regulating cell cycle progression. We previously reported that the trans-activator Tax of human T-cell leukemia virus type I (HTLV-I) induces endogenous cyclin D2 expression along with cell cycle progression in a resting human T-cell line, Kit 225, suggesting a role of cyclin D2 in Tax-mediated cell cycle progression. The cyclin D2 gene has a typical E2F binding element, raising the possibility that induction of cyclin D2 expression is a consequence of cell cycle progression. In this study, we examined the role and molecular mechanism of induction of the endogenous human cyclin D2 gene by Tax. Introduction of p19(INK4d), a cyclin dependent kinase (CDK) inhibitor of the INK4 family specific for D-type CDK, inhibited Tax-mediated activation of E2F, indicating requirement of D-type CDK in Tax-mediated activation of E2F. Previously indicated E2F binding element and two NF-kappaB-like binding elements in the 1.6 kbp cyclin D2 promoter fragment had little, if any, effect on responsiveness to Tax. We found that trans-activation of the cyclin D2 promoter by Tax was mainly mediated by a newly identified NF-kappaB-like element with auxiliary contribution of a CRE-like element residing in sequences downstream of -444 which were by themselves sufficient for trans-activation by Tax. These results indicate that Tax directly trans-activates the cyclin D2 gene, resulting in growth promotion and perhaps leukemogenesis through activation of D-type CDK.

New directions in cognitive educational game design

NARCIS (Netherlands)

Bril, Ivo; Degens, Nick; Braad, Eelco; Allison, Colin; Morgado, Leonel; Pirker, Johanna; Beck, Dennis; Richter, Jonathon; Gütl, Christian

2016-01-01

What makes an educational game good? This paper describes three research directions that could provide insight in the underlying principles of effective educational games. These aspects are 1) The importance of distinguishing between types of to-be-learned knowledge, 2) the need to understand the

Characterizing the Soldering Alloy Type In–Ag–Ti and the Study of Direct Soldering of SiC Ceramics and Copper

Directory of Open Access Journals (Sweden)

Roman Koleňák

2018-04-01

Full Text Available The aim of the research was to characterize the soldering alloy In–Ag–Ti type, and to study the direct soldering of SiC ceramics and copper. The In10Ag4Ti solder has a broad melting interval, which mainly depends on its silver content. The liquid point of the solder is 256.5 °C. The solder microstructure is composed of a matrix with solid solution (In, in which the phases of titanium (Ti3In4 and silver (AgIn2 are mainly segregated. The tensile strength of the solder is approximately 13 MPa. The strength of the solder increased with the addition of Ag and Ti. The solder bonds with SiC ceramics, owing to the interaction between active In metal and silicon infiltrated in the ceramics. XRD analysis has proven the interaction of titanium with ceramic material during the formation of the new minority phases of titanium silicide—SiTi and titanium carbide—C5Ti8. In and Ag also affect bond formation with the copper substrate. Two new phases were also observed in the bond interphase—(CuAg6In5 and (AgCuIn2. The average shear strength of a combined joint of SiC–Cu, fabricated with In10Ag4Ti solder, was 14.5 MPa. The In–Ag–Ti solder type studied possesses excellent solderability with several metallic and ceramic materials.

Die hervertolking van die paradigma in verband met die ...

African Journals Online (AJOL)

Kerkorde van De Mist en die Algemene Reglement van 1816, wat onderskeidelik vir die Kaapse Kerk en die .... Een van die eerstes was Sam Freiherr von Pufendorf (1632-1694) wat in sy werk De habitu religionis ..... Koning was weer aan bewind (vgl Diepenhorst sj:74w; De Visser 1926/1927 lll:202w). 43.1 JD Janssen ...

Die woordeboek vir meganiese ingenieurs: Vorderingsverslag

Directory of Open Access Journals (Sweden)

Editorial Office

1990-07-01

Full Text Available Die komitee van die Nasionale Vakterminologiediens (NVD wat ’n woordeboek vir meganiese ingenieurswese saamstel en in Januarie 1986 met sy werksaamhede begin het, maak goeie vordering. Die dag-tot-dag-werk word deur 'n redaksiekomitee behartig wat twee keer maandeliks vergader en uit verteenwoordigers van universiteite, SAVD, YSKOR, SABS en ander instansies bestaan.

Financial implications for built environment consultants working at ...

African Journals Online (AJOL)

Konsultante in die boubedryf van Suid-Afrika loop finansiële risiko's as gevolg van kliënte se verwagtinge om sekere fases van werk te voltooi teen 'n risiko. Konsultante voltooi dus projekte teen 'n risiko met die hoop op vergoeding in die lang duur. 'n Beskrywende opname is gedoen onder 'n verskeidenheid professionele ...

Optical measurement of surface roughness in manufacturing

Energy Technology Data Exchange (ETDEWEB)

Brodmann, R.

1984-11-01

The measuring system described here is based on the light-scattering method, and was developed by Optische Werke G. Rodenstock, Munich. It is especially useful for rapid non-contact monitoring of surface roughness in production-related areas. This paper outlines the differences between this system and the common stylus instrument, including descriptions of some applications in industry.

Völker strafen

Directory of Open Access Journals (Sweden)

Henning Radtke

2004-01-01

Full Text Available Rezensierte Werke:William A. Schabas, Der Genozid im Völkerrecht, Hamburg: Hamburger Edition HIS 2003, 792 S., ISBN 3-930908-88-3; Gerhard Werle, Völkerstrafrecht (unter Mitarbeit von Florian Jeßberger, Wulf Burchards, Barbara Lüders, Stephan Meseke, Volker Nerlich, Tübingen: Mohr Siebeck 2003, 553 S., ISBN 3-16-148087-2

Missionale kerkwees

African Journals Online (AJOL)

Test

Paul Hooker (2008) werk die begrip soos volg uit: ...... Brunner, E., 1960, Die christliche Lehre von der Kirche, vom Glauben und von ..... P.S., 1960, Images of the church in the New Testament, Westminister John Knox, ... Testament in the Olivétan Bible of 1535', Koers 66(1/2) 1–22. http://dx.doi. .... Harper Collins, New York.

Volkslinguïstiek en dialectlexico¬grafie in de zuidelijke Nederlanden

African Journals Online (AJOL)

Riette Ruthven

mag dat als bewijs gelden dat de notie in het Nederlandse taalgebied zo goed als onbekend is. 'Folk linguistics' is blijkbaar wel bekend in de Angelsaksische wereld, voor een groot deel dank zij het werk van Preston en Niedzielski.2 Met de term wordt het geheel bedoeld van volkse opinies en attitudes tegenover taal; het ...

Differences in maternal responsive and directive behavior during free play with and without aided AAC.

Science.gov (United States)

Medeiros, Kara F; Cress, Cynthia J

2016-06-01

Maternal directive and responsive behaviors were compared for 25 mothers and children with complex communication needs using two types of toys (familiar and unfamiliar toys). Each type of toy play was conducted with and without a single message speech-generating communication device (SGD) programmed to say "more." Rate percentages of coded intervals for maternal directive and responsive behaviors were analyzed using repeated measures ANOVAs. Results indicated that mothers used significantly more responsive behaviors when playing with their own familiar toys than with unfamiliar toys, but no differences in directiveness between types of play. Mothers showed no differences in responsivity or directiveness when the SGD was added to play interactions, indicating that the SGD did not introduce task features that detracted from the mothers' existing levels of responsivity with their children. Clinical implications are discussed.

Direct observations of low-energy solar electrons associated with a type 3 solar radio burst

Science.gov (United States)

Frank, L. A.; Gurnett, D. A.

1972-01-01

On 6 April 1971 a solar X-ray flare and a type 3 solar radio noise burst were observed with instrumentation on the eccentric-orbiting satellite IMP 6. The type 3 solar radio noise burst was detected down to a frequency of 31 kHz. A highly anisotropic packet of low-energy solar electron intensities arrived at the satellite approximately 6000 seconds after the onset of the solar flare. This packet of solar electron intensities was observed for 4200 seconds. Maximum differential intensities of the solar electrons were in the energy range of one to several keV. The frequency drift rate of the type 3 radio noise at frequencies below 178 kHz also indicated an average particle speed corresponding to that of a 3-keV electron. The simultaneous observations of these solar electron intensities and of the type 3 solar radio burst are presented, and their interrelationships are explored.

Direct sequencing of FAH gene in Pakistani tyrosinemia type 1 families reveals a novel mutation.

Science.gov (United States)

Ijaz, Sadaqat; Zahoor, Muhammad Yasir; Imran, Muhammad; Afzal, Sibtain; Bhinder, Munir A; Ullah, Ihsan; Cheema, Huma Arshad; Ramzan, Khushnooda; Shehzad, Wasim

2016-03-01

Hereditary tyrosinemia type 1 (HT1) is a rare inborn error of tyrosine catabolism with a worldwide prevalence of one out of 100,000 live births. HT1 is clinically characterized by hepatic and renal dysfunction resulting from the deficiency of fumarylacetoacetate hydrolase (FAH) enzyme, caused by recessive mutations in the FAH gene. We present here the first report on identification of FAH mutations in HT1 patients from Pakistan with a novel one. Three Pakistani families, each having one child affected with HT1, were enrolled over a period of 1.5 years. Two of the affected children had died as they were presented late with acute form. All regions of the FAH gene spanning exons and splicing sites were amplified by polymerase chain reaction (PCR) and mutation analysis was carried out by direct sequencing. Results of sequencing were confirmed by restriction fragment length polymorphism (PCR-RFLP) analysis. Three different FAH mutations, one in each family, were found to co-segregate with the disease phenotype. Two of these FAH mutations have been known (c.192G>T and c.1062+5G>A [IVS12+5G>A]), while c.67T>C (p.Ser23Pro) was a novel mutation. The novel variant was not detected in any of 120 chromosomes from normal ethnically matched individuals. Most of the HT1 patients die before they present to hospitals in Pakistan, as is indicated by enrollment of only three families in 1.5 years. Most of those with late clinical presentation do not survive due to delayed diagnosis followed by untimely treatment. This tragic condition advocates the establishment of expanded newborn screening program for HT1 within Pakistan.

Filmless radiography - present possibilities and direction of future developing

International Nuclear Information System (INIS)

Wocial, A.; Wojciechowski, Z.A.; Rozenblicki, Z.

2008-01-01

The paper presents introduction for new filmless radiography like CR Computed Radiography and DR Digital Radiography direct and non direct. The main factors are considered, which determine classification to different type of radiography. For each technique authors describe advantages and disadvantages supporting by practice examples. Paper contains a lot of practical information about a most of existing radiographic equipment at the NDT market. (author)

Approximately One In Three US Adults Completes Any Type Of Advance Directive For End-Of-Life Care.

Science.gov (United States)

Yadav, Kuldeep N; Gabler, Nicole B; Cooney, Elizabeth; Kent, Saida; Kim, Jennifer; Herbst, Nicole; Mante, Adjoa; Halpern, Scott D; Courtright, Katherine R

2017-07-01

Efforts to promote the completion of advance directives implicitly assume that completion rates of these documents, which help ensure care consistent with people's preferences in the event of incapacity, are undesirably low. However, data regarding completion of advance directives in the United States are inconsistent and of variable quality. We systematically reviewed studies published in the period 2011-16 to determine the proportion of US adults with a completed living will, health care power of attorney, or both. Among the 795,909 people in the 150 studies we analyzed, 36.7 percent had completed an advance directive, including 29.3 percent with living wills. These proportions were similar across the years reviewed. Similar proportions of patients with chronic illnesses (38.2 percent) and healthy adults (32.7 percent) had completed advance directives. The findings provide benchmarks for gauging future policies and practices designed to motivate completion of advance directives, particularly among those people most likely to benefit from having these documents on record. Project HOPE—The People-to-People Health Foundation, Inc.

Statistical theory of multi-step compound and direct reactions

International Nuclear Information System (INIS)

Feshbach, H.; Kerman, A.; Koonin, S.

1980-01-01

The theory of nuclear reactions is extended so as to include a statistical treatment of multi-step processes. Two types are distinguished, the multi-step compound and the multi-step direct. The wave functions for the system are grouped according to their complexity. The multi-step direct process involves explicitly those states which are open, while the multi-step compound involves those which are bound. In addition to the random phase assumption which is applied differently to the multi-step direct and to the multi-step compound cross-sections, it is assumed that the residual interaction will have non-vanishing matrix elements between states whose complexities differ by at most one unit. This is referred to as the chaining hypothesis. Explicit expressions for the double differential cross-section giving the angular distribution and energy spectrum are obtained for both reaction types. The statistical multi-step compound cross-sections are symmetric about 90 0 . The classical statistical theory of nuclear reactions is a special limiting case. The cross-section for the statistical multi-step direct reaction consists of a set of convolutions of single-step direct cross-sections. For the many step case it is possible to derive a diffusion equation in momentum space. Application is made to the reaction 181 Ta(p,n) 181 W using the statistical multi-step compound formalism

Direct electrochemistry of CueO and its mutants at residues to and near type I Cu for oxygen-reducing biocathode

Energy Technology Data Exchange (ETDEWEB)

Miura, Y.; Kamitaka, Y. [Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku (Japan); Kurose, S.; Kataoka, K.; Sakurai, T. [Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa (Japan); Tsujimura, S.; Kano, K.

2009-02-15

CueO, a multi-copper oxidase (MCO) occurring in Escherichia coli, catalyses a four-electron reduction of O{sub 2} in a direct electron transfer (DET) mechanism with very high electrocatalytic activity on carbon aerogel electrodes. However, the overpotential of CueO is greater than that in other MCOs. By understanding the redox properties of CueO, we attempted to reduce this overpotential. Direct electrochemistry of CueO on carbon aerogel electrodes showed a pair of redox waves derived from the type I (T1) Cu site with a redox potential (E {sup circle} {sup '} atop T1) of 0.28 V versus Ag vertical stroke AgCl at pH 5.0. Dependence of E {sup circle} {sup '} atop T1 on pH suggests the participation of proton transfer and acid-base equilibrium of some amino acid residue. The shape of the catalytic current is consistent with the T1 site being an inlet of electrons in the DET bioelectrocatalysis of O{sub 2}, in which case the overpotential could be reduced by shifting E {sup circle} {sup '} atop T1 towards the positive potential. To achieve this, we created mutants of CueO at M510, which is the axial ligand of the T1 Cu, and at D439, which forms a hydrogen bond with His443 coordinated with the T1 Cu. Two mutants, M510L and D439A, successfully reduced the overpotential. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids.

Science.gov (United States)

Holmes, Megan C; Abrahamsen, Christian T; French, Karen L; Paterson, Janice M; Mullins, John J; Seckl, Jonathan R

2006-04-05

Low birth weight associates with increased susceptibility to adult cardiometabolic and affective disorders spawning the notion of fetal "programming." Prenatal exposure to excess glucocorticoids may be causal. In support, maternal stress or treatment during pregnancy with dexamethasone (which crosses the placenta) or inhibitors of fetoplacental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the physiological "barrier" to maternal glucocorticoids, reduces birth weight and programs permanent offspring hypertension, hyperglycemia, and anxiety behaviors. It remains uncertain whether such effects are mediated indirectly via altered maternal function or directly on the fetus and its placenta. To dissect this critical issue, we mated 11beta-HSD2(+/-) mice such that each pregnant female produces +/+, +/-, and -/- offspring and compared them with offspring of homozygous wild-type and -/- matings. We show that 11beta-HSD2(-/-) offspring of either +/- or -/- mothers have lower birth weight and exhibit greater anxiety than 11beta-HSD2(+/+) littermates. This provides clear evidence for the key role of fetoplacental 11beta-HSD2 in prenatal glucocorticoid programming.

Casing pull tests for directionally drilled environmental wells

International Nuclear Information System (INIS)

Staller, G.E.; Wemple, R.P.; Layne, R.R.

1994-11-01

A series of tests to evaluate several types of environmental well casings have been conducted by Sandia National Laboratories (SNL) and it's industrial partner, The Charles Machine Works, Inc. (CMW). A test bed was constructed at the CMW test range to model a typical shallow, horizontal, directionally drilled wellbore. Four different types of casings were pulled through this test bed. The loads required to pull the casings through the test bed and the condition of the casing material were documented during the pulling operations. An additional test was conducted to make a comparison of test bed vs actual wellbore casing pull loads. A directionally drilled well was emplaced by CMW to closely match the test bed. An instrumented casing was installed in the well and the pull loads recorded. The completed tests are reviewed and the results reported

Casing pull tests for directionally drilled environmental wells

Energy Technology Data Exchange (ETDEWEB)

Staller, G.E.; Wemple, R.P. [Sandia National Labs., Albuquerque, NM (United States); Layne, R.R. [Charles Machine Works, Inc., Perry, OK (United States)

1994-11-01

A series of tests to evaluate several types of environmental well casings have been conducted by Sandia National Laboratories (SNL) and it`s industrial partner, The Charles Machine Works, Inc. (CMW). A test bed was constructed at the CMW test range to model a typical shallow, horizontal, directionally drilled wellbore. Four different types of casings were pulled through this test bed. The loads required to pull the casings through the test bed and the condition of the casing material were documented during the pulling operations. An additional test was conducted to make a comparison of test bed vs actual wellbore casing pull loads. A directionally drilled well was emplaced by CMW to closely match the test bed. An instrumented casing was installed in the well and the pull loads recorded. The completed tests are reviewed and the results reported.

Siglenverzeichnis und Abkürzungen der Werke Wittgensteins

OpenAIRE

2017-01-01

AüL Aufzeichnungen über Logik BB Aufzeichnungen über Logik BGM Bemerkungen über die Grundlagen der Mathematik BLF Bemerkungen über logische Form BPP Bemerkungen über die Philosophie der Psychologie BüF Bemerkungen über die Farben PB Philosophische Bemerkungen PG Philosophische Grammatik PU Philosophische Untersuchungen T Tractatus Logico-philosophicus TB Tagebücher 1914-1916 ÜG Über Gewißheit V&G Vorlesungen und Gespräche über Ästhetik, Psychoanalyse und religiösen Glauben WWK Wittgenstein un...

Titan en Christiaan. Huygens in werk en leven

NARCIS (Netherlands)

Dijksterhuis, Fokko J.

2000-01-01

In three respects Christiaan Huygens (1629-1695) poses a biographical problem. Unlike contemporaries he hardly ever reflected upon what he thought he was doing; his versatility makes it hard to gain a balanced view of what he was doing; his personality seems almost absent from his writings. In the

Language input and acquisition in a Mayan village: how important is directed speech?

Science.gov (United States)

Shneidman, Laura A; Goldin-Meadow, Susan

2012-09-01

Theories of language acquisition have highlighted the importance of adult speakers as active participants in children's language learning. However, in many communities children are reported to be directly engaged by their caregivers only rarely (Lieven, 1994). This observation raises the possibility that these children learn language from observing, rather than participating in, communicative exchanges. In this paper, we quantify naturally occurring language input in one community where directed interaction with children has been reported to be rare (Yucatec Mayan). We compare this input to the input heard by children growing up in large families in the United States, and we consider how directed and overheard input relate to Mayan children's later vocabulary. In Study 1, we demonstrate that 1-year-old Mayan children do indeed hear a smaller proportion of total input in directed speech than children from the US. In Study 2, we show that for Mayan (but not US) children, there are great increases in the proportion of directed input that children receive between 13 and 35 months. In Study 3, we explore the validity of using videotaped data in a Mayan village. In Study 4, we demonstrate that word types directed to Mayan children from adults at 24 months (but not word types overheard by children or word types directed from other children) predict later vocabulary. These findings suggest that adult talk directed to children is important for early word learning, even in communities where much of children's early language input comes from overheard speech. © 2012 Blackwell Publishing Ltd.

Evolution of genetic architecture under directional selection.

Science.gov (United States)

Hansen, Thomas F; Alvarez-Castro, José M; Carter, Ashley J R; Hermisson, Joachim; Wagner, Günter P

2006-08-01

We investigate the multilinear epistatic model under mutation-limited directional selection. We confirm previous results that only directional epistasis, in which genes on average reinforce or diminish each other's effects, contribute to the initial evolution of mutational effects. Thus, either canalization or decanalization can occur under directional selection, depending on whether positive or negative epistasis is prevalent. We then focus on the evolution of the epistatic coefficients themselves. In the absence of higher-order epistasis, positive pairwise epistasis will tend to weaken relative to additive effects, while negative pairwise epistasis will tend to become strengthened. Positive third-order epistasis will counteract these effects, while negative third-order epistasis will reinforce them. More generally, gene interactions of all orders have an inherent tendency for negative changes under directional selection, which can only be modified by higher-order directional epistasis. We identify three types of nonadditive quasi-equilibrium architectures that, although not strictly stable, can be maintained for an extended time: (1) nondirectional epistatic architectures; (2) canalized architectures with strong epistasis; and (3) near-additive architectures in which additive effects keep increasing relative to epistasis.

FOREIGN DIRECT INVESTMENTS DURING FINANCIAL CRISES

Directory of Open Access Journals (Sweden)

VINTILA DENISIA MARIANA

2011-12-01

Full Text Available The fundamental idea of International capital flows is that short-term flows can be easily reversed, while flows on a longer time horizon are more stable. Crises are associated with withdrawals of short-term capital flows and growth of the foreign direct investment flows. The current crisis has meant a major decline of international capital flows, also of the foreign direct investment. The analysis in this article tries to establish if and under which conditions foreign direct investments can bring greater stability during the crisis, comparing the evolution of foreign direct investments in the current crisis with their response in previous crises. We show that during previous crises foreign direct investments were stable, behaving differently from other types of capital. Yet, during the current crisis, foreign direct investments have proven to be not so stable and all the components declined, raising questions about the resumption of the positive trend. The stability of foreign direct investments in the past was given by the increase of mergers and acquisitions during the crisis, reflecting fire-sale FDI. This feature is not found in the current crisis as mergers and acquisitions were severe affected by the crises and recorded a major decline. The current paper is realized in the doctoral program entitled PhD in economics at the standards of European knowledge- DoEsEc, scientific coordinator Prof. PhD Rodica Zaharia, institution The Academy of Economic Studies Bucharest, Faculty of International Business, period of research 2009-2012.

Role of a non-ionic surfactant in direct electron transfer-type bioelectrocatalysis by fructose dehydrogenase

International Nuclear Information System (INIS)

Kawai, Shota; Yakushi, Toshiharu; Matsushita, Kazunobu; Kitazumi, Yuki; Shirai, Osamu; Kano, Kenji

2015-01-01

Highlights: • Addition of Triton ® X-100 (1%) completely quenches the FDH-catalyzed current at hydrophobic electrode, but causes only small competitive effect at hydrophilic electrode. • Quartz crystal microbalance measurements support the adsorption of FDH and Triton ® X-100 on both of the electrodes. • The surfactant forms a monolayer on the hydrophobic electrode and FDH adsorbs on the surfactant monolayer. • The surfactant forms a bilayer on the hydrophilic electrode and FDH is embedded in the bilayer to communicate with the electrode. - ABSTRACT: A heterotrimeric membrane-bound fructose dehydrogenase (FDH) from Gluconobacter japonicus NBRC3260 contains FAD in subunit I and three heme C moieties in subunit II as the redox centers, and is one of the direct electron transfer (DET)-type redox enzymes. FDH-catalyzed current density of fructose oxidation at hydrophilic mercaptoethanol (MEtOH)-modified Au electrode is much larger than that at hydrophobic mercaptoethane (MEtn)-modified Au electrode. Addition of a non-ionic surfactant Triton ® X-100 (1%) completely quenches the catalytic current at the MEtn-modified Au electrode, while only small competitive effect is observed at the MEtOH-modified Au electrode. Quartz crystal microbalance measurements support the adsorption of FDH and Triton ® X-100 on both of the modified electrodes. We propose a model to explain the phenomenon as follows. The surfactant forms a monolayer on the hydrophobic MEtn-modified electrode with strong hydrophobic interaction, and FDH adsorbs on the surface of the surfactant monolayer. The monolayer inhibits the electron transfer from FDH to the electrode. On the other hand, the surfactant forms a bilayer on the hydrophilic MEtOH-modified electrode. The interaction between the surfactant bilayer and the hydrophilic electrode is relatively weak so that FDH replaces the surfactant and is embedded in the bilayer to communicate electrochemically with the hydrophilic electrode

Voorwoord

Directory of Open Access Journals (Sweden)

D.F.M. Strauss

2011-06-01

Full Text Available Om ’n Festschrift ter ere van die akademiese werk van ’n kollega en medewetenskaplike te publiseer, is sekerlik een van die mees lonende intellektuele gebeurtenisse wat so ’n akademikus kan ervaar. Dit is daarom ook ’n besondere voorreg om die taak opgedra te word om ’n Voorwoord vir hierdie Festschrift te skryf.

Gerhard Ebeling oor geloof

African Journals Online (AJOL)

29 Jul 2016 ... oor die saak wat ter tafel is. Polemiek oor ander teoloë se standpunte vorm nie deel van Ebeling se werk nie en direkte teologiese debat met ander is skaars in sy oeuvre. Ebeling dink radikaal krities met 'n fyn hermeneutiese aanvoeling vir die lewe as denkkonteks eerder as dat hy die een of ander sisteem ...

Ek wil hier graag van die geleentheid gebruik maak am die ...

African Journals Online (AJOL)

die wildlewe am van die jagters nie eers mel- ding te maak nie en in Lucas se werk kan hulle ure van genot deurbring. Wat ons veral in Lucas se publikasie interes- seer is sy deelname aan die agste grensoor~' log (1850-1853), sy aantekeninge in verband met die slag by Berea (20 Oesember 1852) en sy indrukke van ...

Die metafoor by Breyten Breytenbach

African Journals Online (AJOL)

Owner

23 Jun 2009 ... metafories, of spesifiek verwysend, te werk gegaan is. Tyd sou mens die hoofmotief van die bundel noem, tyd en geheue wat verbygaan: 1 en 2; en die einde van die storie wat gekom het: “fluit-fluit my storie is uit”. (Die tema van verbygaan word weer opgeneem in 8 en 9: die stories wat nooit meer gehoor ...

Land van skedels. Nicola Hanekom. Pretoria: Protea Boekhuis ...

African Journals Online (AJOL)

tema is, soos te verwagte in 'n stuk wat werk met historiese materiaal, die tema van onthou. Reeds in die “skrywersnota” stel Nicola Hanekom dat “[o]ns moet altyd onthou om te onthou. Ons vergeet dit soms. Ons moet die dier binne ons in toom hou en probeer luister na die engele in die chaos”. Die gevaar van vergeet is.

Change and Continuity in Librarianship: Approaching the Twenty-First Century. Proceedings of the 40th Military Librarians Workshop, 20-22 November 1996, Annapolis, Maryland,

Science.gov (United States)

1996-11-01

Novembecr 1996 Arinarolis, Maryland1 rDIO QUALMTY DZEOTN I VIBYKUTON UrtAIK=yg A Change and Continuity in Librarianship : Approaching the Twenty-first...speakers Walt Crawford (Keynote), speaking on "Millennial Librarianship ;" Dr. Keith Swigger, Dean of the Graduate School of Library and Information...1 --Richard Hume Werking Millennial Librarianship : Maintaining the Mix and Avoiding the Hype .................. 2 --Walt Crawford

78 FR 52870 - Airworthiness Directives; Beechcraft Corporation Airplanes

Science.gov (United States)

2013-08-27

... Airworthiness Directives; Beechcraft Corporation Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for certain Beechcraft Corporation (type certificate previously held by Hawker Beechcraft Corporation) Models 1900, 1900C, and 1900D airplanes. This proposed AD was prompted by reports of cracking in...