WorldWideScience

Sample records for direction amount timing

  1. Amount of Postcue Encoding Predicts Amount of Directed Forgetting

    Science.gov (United States)

    Pastotter, Bernhard; Bauml, Karl-Heinz

    2010-01-01

    In list-method directed forgetting, participants are cued to intentionally forget a previously studied list (List 1) before encoding a subsequently presented list (List 2). Compared with remember-cued participants, forget-cued participants typically show impaired recall of List 1 and improved recall of List 2, referred to as List 1 forgetting and…

  2. The direction of time

    CERN Document Server

    Reichenbach, Hans

    1999-01-01

    Ever a source of philosophical conjecture and debate, the concept of time represents the beating heart of physics. This final work by the distinguished physicist Hans Reichenbach represents the culmination and integration of a lifetime's philosophical contributions and inquiries into the analysis of time. The result is an outstanding overview of such qualitative, or topological, attributes of time as order and direction.Beginning with a discussion of the emotive significance of time, Reichenbach turns to an examination of the time order of mechanics, the time direction of thermodynamics and m

  3. 29 CFR 4206.7 - Amount of credit in plans using the direct attribution method.

    Science.gov (United States)

    2010-07-01

    ... TO A PARTIAL WITHDRAWAL § 4206.7 Amount of credit in plans using the direct attribution method. In a plan that uses the direct attribution allocation method described in section 4211(c)(4) of ERISA, the... 29 Labor 9 2010-07-01 2010-07-01 false Amount of credit in plans using the direct attribution...

  4. The suprachiasmatic nucleus regulates sleep timing and amount in mice

    NARCIS (Netherlands)

    Easton, Amy; Meerlo, Peter; Bergmann, Bernard; Turek, Fred W.

    2004-01-01

    Context: Sleep is regulated by circadian and homeostatic processes. The circadian pacemaker, located in the suprachiasmatic nuclei (SCN), regulates the timing and consolidation of the sleep-wake cycle, while a homeostatic mechanism governs the accumulation of sleep debt and sleep, recovery. Recent

  5. Measurements of Nitrogen Dioxide Total Column Amounts using a Brewer Double Spectrophotometer in Direct Sun Mode

    Science.gov (United States)

    Cede, Alexander; Herman, Jay; Richter, Andreas; Krotkov, Nickolay; Burrows, John

    2006-01-01

    NO2 column amounts were measured for the past 2 years at Goddard Space Flight Center, Greenbelt, Maryland, using a Brewer spectrometer in direct Sun mode. A new bootstrap method to calibrate the instrument is introduced and described. This technique selects the cleanest days from the database to obtain the solar reference spectrum. The main advantage for direct Sun measurements is that the conversion uncertainty from slant column to vertical column is negligible compared to the standard scattered light observations where it is typically on the order of 100% (2sigma) at polluted sites. The total 2sigma errors of the direct Sun retrieved column amounts decrease with solar zenith angle and are estimated at 0.2 to 0.6 Dobson units (DU, 1 DU approx. equal to 2.7 10(exp 16) molecules cm(exp -2)), which is more accurate than scattered light measurements for high NO2 amounts. Measured NO2 column amounts, ranging from 0 to 3 DU with a mean of 0.7 DU, show a pronounced daily course and a strong variability from day to day. The NO2 concentration typically increases from sunrise to noon. In the afternoon it decreases in summer and stays constant in winter. As expected from the anthropogenic nature of its source, NO2 amounts on weekends are significantly reduced. The measurements were compared to satellite retrievals from Scanning Image Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY). Satellite data give the same average NO2 column and show a seasonal cycle that is similar to the ground data in the afternoon. We show that NO2 must be considered when retrieving aerosol absorption properties, especially for situations with low aerosol optical depth.

  6. The Amount of Time Dilation for Visual Flickers Corresponds to the Amount of Neural Entrainments Measured by EEG.

    Science.gov (United States)

    Hashimoto, Yuki; Yotsumoto, Yuko

    2018-01-01

    The neural basis of time perception has long attracted the interests of researchers. Recently, a conceptual model consisting of neural oscillators was proposed and validated by behavioral experiments that measured the dilated duration in perception of a flickering stimulus (Hashimoto and Yotsumoto, 2015). The model proposed that flickering stimuli cause neural entrainment of oscillators, resulting in dilated time perception. In this study, we examined the oscillator-based model of time perception, by collecting electroencephalography (EEG) data during an interval-timing task. Initially, subjects observed a stimulus, either flickering at 10-Hz or constantly illuminated. The subjects then reproduced the duration of the stimulus by pressing a button. As reported in previous studies, the subjects reproduced 1.22 times longer durations for flickering stimuli than for continuously illuminated stimuli. The event-related potential (ERP) during the observation of a flicker oscillated at 10 Hz, reflecting the 10-Hz neural activity phase-locked to the flicker. Importantly, the longer reproduced duration was associated with a larger amplitude of the 10-Hz ERP component during the inter-stimulus interval, as well as during the presentation of the flicker. The correlation between the reproduced duration and the 10-Hz oscillation during the inter-stimulus interval suggested that the flicker-induced neural entrainment affected time dilation. While the 10-Hz flickering stimuli induced phase-locked entrainments at 10 Hz, we also observed event-related desynchronizations of spontaneous neural oscillations in the alpha-frequency range. These could be attributed to the activation of excitatory neurons while observing the flicker stimuli. In addition, neural activity at approximately the alpha frequency increased during the reproduction phase, indicating that flicker-induced neural entrainment persisted even after the offset of the flicker. In summary, our results suggest that the

  7. Possible chaoticity for the time series of the amount of nuclear information released by the newsmedia

    International Nuclear Information System (INIS)

    Ohnishi, T.

    1995-01-01

    The amount of information concerning nuclear problems was time analysed which has been released by three types of the newsmedia in Japan, the press, television and magazines during the past 20 years. The time series of the logarithmic value of the amount released by some of the newsmedia was found to be possibly chaotic, or at least to be non-stochastic. Such a characteristic of time series can be interpreted as a result of the exertion of a certain sort of selection process in the interior of the newsmedia in deciding an event as news to be released. (author)

  8. Modelling financial markets with agents competing on different time scales and with different amount of information

    Science.gov (United States)

    Wohlmuth, Johannes; Andersen, Jørgen Vitting

    2006-05-01

    We use agent-based models to study the competition among investors who use trading strategies with different amount of information and with different time scales. We find that mixing agents that trade on the same time scale but with different amount of information has a stabilizing impact on the large and extreme fluctuations of the market. Traders with the most information are found to be more likely to arbitrage traders who use less information in the decision making. On the other hand, introducing investors who act on two different time scales has a destabilizing effect on the large and extreme price movements, increasing the volatility of the market. Closeness in time scale used in the decision making is found to facilitate the creation of local trends. The larger the overlap in commonly shared information the more the traders in a mixed system with different time scales are found to profit from the presence of traders acting at another time scale than themselves.

  9. Simplified assessment of segmental gastrointestinal transit time with orally small amount of barium

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Weitang; Zhang, Zhiyong; Liu, Jinbo; Li, Zhen; Song, Junmin; Wu, Changcai [Department of Colorectal Surgery, The First Affiliated Hospital and Institute of Clinical Medicine, Zhengzhou University, 450052 Zhengzhou (China); Wang, Guixian, E-mail: guixianwang@hotmail.com [Department of Colorectal Surgery, The First Affiliated Hospital and Institute of Clinical Medicine, Zhengzhou University, 450052 Zhengzhou (China)

    2012-09-15

    Objective: To determine the effectiveness and advantage of small amount of barium in the measurement of gastrointestinal transmission function in comparison with radio-opaque pallets. Methods: Protocal 1: 8 healthy volunteers (male 6, female 2) with average age 40 ± 6.1 were subjected to the examination of radio-opaque pellets and small amount of barium with the interval of 1 week. Protocol 2: 30 healthy volunteers in group 1 (male 8, female 22) with average age 42.5 ± 8.1 and 50 patients with chronic functional constipation in group 2 (male 11, female 39) with average age 45.7 ± 7.8 were subjected to the small amount of barium examination. The small amount of barium was made by 30 g barium dissolved in 200 ml breakfast. After taking breakfast which contains barium, objectives were followed with abdominal X-ray at 4, 8, 12, 24, 48, 72, 96 h until the barium was evacuated totally. Results: Small amount of barium presented actual chyme or stool transit. The transit time of radio-opaque pallets through the whole gastrointestinal tract was significantly shorter than that of barium (37 ± 8 h vs. 47 ± 10 h, P < 0.05) in healthy people. The transit times of barium in constipation patients were markedly prolonged in colon (61.1 ± 22 vs. 37.3 ± 11, P < 0.01) and rectum (10.8 ± 3.7 vs. 2.3 ± 0.8 h, P < 0.01) compared with unconstipated volunteers. Transit times in individual gastrointestinal segments were also recorded by using small amount of barium, which allowed identifying the subtypes of constipation. Conclusion: The small amount barium examination is a convenient and low cost method to provide the most useful and reliable information on the transmission function of different gastrointestinal segments and able to classify the subtypes of slow transit constipation.

  10. Simplified assessment of segmental gastrointestinal transit time with orally small amount of barium

    International Nuclear Information System (INIS)

    Yuan, Weitang; Zhang, Zhiyong; Liu, Jinbo; Li, Zhen; Song, Junmin; Wu, Changcai; Wang, Guixian

    2012-01-01

    Objective: To determine the effectiveness and advantage of small amount of barium in the measurement of gastrointestinal transmission function in comparison with radio-opaque pallets. Methods: Protocal 1: 8 healthy volunteers (male 6, female 2) with average age 40 ± 6.1 were subjected to the examination of radio-opaque pellets and small amount of barium with the interval of 1 week. Protocol 2: 30 healthy volunteers in group 1 (male 8, female 22) with average age 42.5 ± 8.1 and 50 patients with chronic functional constipation in group 2 (male 11, female 39) with average age 45.7 ± 7.8 were subjected to the small amount of barium examination. The small amount of barium was made by 30 g barium dissolved in 200 ml breakfast. After taking breakfast which contains barium, objectives were followed with abdominal X-ray at 4, 8, 12, 24, 48, 72, 96 h until the barium was evacuated totally. Results: Small amount of barium presented actual chyme or stool transit. The transit time of radio-opaque pallets through the whole gastrointestinal tract was significantly shorter than that of barium (37 ± 8 h vs. 47 ± 10 h, P < 0.05) in healthy people. The transit times of barium in constipation patients were markedly prolonged in colon (61.1 ± 22 vs. 37.3 ± 11, P < 0.01) and rectum (10.8 ± 3.7 vs. 2.3 ± 0.8 h, P < 0.01) compared with unconstipated volunteers. Transit times in individual gastrointestinal segments were also recorded by using small amount of barium, which allowed identifying the subtypes of constipation. Conclusion: The small amount barium examination is a convenient and low cost method to provide the most useful and reliable information on the transmission function of different gastrointestinal segments and able to classify the subtypes of slow transit constipation

  11. The impact of tuition fees amount on mental health over time in British students.

    Science.gov (United States)

    Richardson, T; Elliott, P; Roberts, R

    2015-09-01

    Previous studies have shown a relationship between debt and mental health problems in students. This study aimed to examine the effect of differences in tuition fees amount on changes in mental health over time. A prospective cohort study followed 390 first-year British students who differed on their tuition fees level at 4 time points across their first 2 years at university. Participants completed measures of global mental health, depression, anxiety, stress, alcohol-related problems at up to four time points in their first two years at university. Mixed-factorial ANOVAs were used to assess the impact of tuition fees amount on changes in scores over time. There was no difference based on fees at Time 1 for anxiety, stress, depression and global mental health. At Time 2, those charged £0-2.9k or £3-4k improved while those charged £8-9k stayed the same. However, this trend reversed by Times 3 and 4. Undergraduates mental health is partially affected by the level of tuition fees; however, the recent increase in tuition fees does not appear to have had a lasting impact at present. © The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. Dependence of the amount of open magnetic flux on the direction of the interplanetary magnetic field

    International Nuclear Information System (INIS)

    Akasofu, S.I.; Ahn, B.H.

    1980-01-01

    The power generated by the solar wind-magnetosphere dynamo is proportional to the amount of the open magnetic flux phi. It is difficult to use this fact in determining observationally the dependence of phi on the orientation of the interplanetary magnetic field vector. It is shown that, for a simple vacuum superposition of the earth's dipole field and a uniform magnetic field, PHI is very closely proportional to sin(theta/2) for a wide range of the intensity of the uniform field, where theta denotes the polar angle of the interplanetary magnetic field vector in the Y-Z plane of solar-magnetospheric coordinates. (author)

  13. Factors Influencing Amount of Weekly Exercise Time in Colorectal Cancer Survivors.

    Science.gov (United States)

    Chou, Yun-Jen; Lai, Yeur-Hur; Lin, Been-Ren; Liang, Jin-Tung; Shun, Shiow-Ching

    Performing regular exercise of at least 150 minutes weekly has benefits for colorectal cancer survivors. However, barriers inhibit these survivors from performing regular exercise. The aim of this study was to explore exercise behaviors and significant factors influencing weekly exercise time of more than 150 minutes in colorectal cancer survivors. A cross-sectional study design was used to recruit participants in Taiwan. Guided by the ecological model of health behavior, exercise barriers were assessed including intrapersonal, interpersonal, and environment-related barriers. A multiple logistic regression was used to explore the factors associated with the amount of weekly exercise. Among 321 survivors, 57.0% of them had weekly exercise times of more than 150 minutes. The results identified multiple levels of significant factors related to weekly exercise times including intrapersonal factors (occupational status, functional status, pain, interest in exercise, and beliefs about the importance of exercise) and exercise barriers related to environmental factors (lack of time and bad weather). No interpersonal factors were found to be significant. Colorectal cancer survivors experienced low levels of physical and psychological distress. Multiple levels of significant factors related to exercise time including intrapersonal factors as well as exercise barriers related to environmental factors should be considered. Healthcare providers should discuss with their patients how to perform exercise programs; the discussion should address multiple levels of the ecological model such as any pain problems, functional status, employment status, and time limitations, as well as community environment.

  14. Is direct measurement of time possible?

    Science.gov (United States)

    Reynolds, Thomas

    2017-08-01

    Is direct measurement of time possible? The answer to this question may depend upon how one understands time. Is time an essential constituent of physical reality? Or is what scientists are talking about when they use the symbol ‘t’ or the word ‘time’ an human cultural construct, as the Chief of the USA NIST Divisions of Time and Frequency and of Quantum Physics has suggested. Few aspects of physics do not reference activity to time, but many discussions within either view of time seem to use one same, largely traditional, language of time. Briefly considering the question of measurement, including from a formal measure-theoretic point of view, clarifies the situation.

  15. Dynamics of Choice: Relative Rate and Amount Affect Local Preference at Three Different Time Scales

    Science.gov (United States)

    Aparicio, Carlos F.; Baum, William M.

    2009-01-01

    To examine extended control over local choice, the present study investigated preference in transition as food-rate ratio provided by two levers changed across seven components within daily sessions, and food-amount ratio changed across phases. Phase 1 arranged a food-amount ratio of 4:1 (i.e., the left lever delivered four pellets and the right…

  16. Association between Activated Partial Thromboplastin Time and the Amount of Infused Heparin at Bone Marrow Transplantation.

    Science.gov (United States)

    Kusuda, Machiko; Kimura, Shun-Ichi; Misaki, Yukiko; Yoshimura, Kazuki; Gomyo, Ayumi; Hayakawa, Jin; Tamaki, Masaharu; Akahoshi, Yu; Ugai, Tomotaka; Kameda, Kazuaki; Wada, Hidenori; Ishihara, Yuko; Kawamura, Koji; Sakamoto, Kana; Sato, Miki; Terasako-Saito, Kiriko; Kikuchi, Misato; Nakasone, Hideki; Kako, Shinichi; Tanihara, Aki; Kanda, Yoshinobu

    2018-03-27

    The actual heparin concentration of harvested allogeneic bone marrow varies among harvest centers. We monitor the activated partial thromboplastin time (APTT) of the patient during bone marrow infusion and administer prophylactic protamine according to the APTT. We retrospectively reviewed the charts of consecutive patients who underwent bone marrow transplantation without bone marrow processing at our center between April 2007 and March 2016 (n = 94). APTT was monitored during marrow transfusion in 52 patients. We analyzed the relationship between the APTT ratio and several parameters related to heparin administration. As a result, the weight-based heparin administration rate (U/kg/hour) seemed to be more closely related to the APTT ratio (r = .38, P = .005) than to the total amount of heparin. There was no significant correlation between the APTT ratio and renal or liver function. Bleeding complications during and early after infusion were seen in 3 of 52 patients, and included intracranial, nasal, and punctured-skin bleeding. The APTT ratio during transfusion was over 5.88 in the former 2 patients and 2.14 in the latter. All of these patients recovered without sequelae. In conclusion, slow bone marrow infusion is recommended to decrease the weight-based heparin administration rate when the heparin concentration per patient body weight is high. Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  17. Optimization of the integration time of pulse shape analysis for dual-layer GSO detector with different amount of Ce

    International Nuclear Information System (INIS)

    Yamamoto, Seiichi

    2008-01-01

    For a multi-layer depth-of-interaction (DOI) detector using different decay times, pulse shape analysis based on two different integration times is often used to distinguish scintillators in DOI direction. This method measures a partial integration and a full integration, and calculates the ratio of these two to obtain the pulse shape distribution. The full integration time is usually set to integrate full width of the scintillation pulse. However, the optimum partial integration time is not obvious for obtaining the best separation of the pulse shape distribution. To make it clear, a theoretical analysis and experiments were conducted for pulse shape analysis by changing the partial integration time using a scintillation detector of GSOs with different amount of Ce. A scintillation detector with 1-in. round photomultiplier tube (PMT) optically coupled GSO of 1.5 mol% (decay time: 35 ns) and that of 0.5 mol% (decay time: 60 ns) was used for the experiments. The signal from PMT was digitally integrated with partial (50-150 ns) and full (160 ns) integration times and ratio of these two was calculated to obtain the pulse shape distribution. In the theoretical analysis, partial integration time of 50 ns showed largest distance between two peaks of the pulse shape distribution. In the experiments, it showed maximum at 70-80 ns of partial integration time. The peak to valley ratio showed the maximum at 120-130 ns. Because the separation of two peaks is determined by the peak to valley ratio, we conclude the optimum partial integration time for these combinations of GSOs is around 120-130 ns, relatively longer than the expected value

  18. Univariate time series modeling and an application to future claims amount in SOCSO's invalidity pension scheme

    Science.gov (United States)

    Chek, Mohd Zaki Awang; Ahmad, Abu Bakar; Ridzwan, Ahmad Nur Azam Ahmad; Jelas, Imran Md.; Jamal, Nur Faezah; Ismail, Isma Liana; Zulkifli, Faiz; Noor, Syamsul Ikram Mohd

    2012-09-01

    The main objective of this study is to forecast the future claims amount of Invalidity Pension Scheme (IPS). All data were derived from SOCSO annual reports from year 1972 - 2010. These claims consist of all claims amount from 7 benefits offered by SOCSO such as Invalidity Pension, Invalidity Grant, Survivors Pension, Constant Attendance Allowance, Rehabilitation, Funeral and Education. Prediction of future claims of Invalidity Pension Scheme will be made using Univariate Forecasting Models to predict the future claims among workforce in Malaysia.

  19. Exposure amount and timing of solar irradiation during pregnancy and the risk of sensitization in children.

    Science.gov (United States)

    Koh, Hyun Yong; Cho, Eunhae; Lee, So-Yeon; Kim, Woo Kyung; Park, Yong Mean; Kim, Jihyun; Ahn, Kangmo; Lee, Seung Won; Kim, Mi Ae; Hahm, Myung-Il; Chae, Yoomi; Lee, Kee-Jae; Kwon, Ho-Jang; Han, Man Yong

    2018-04-01

    Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. This population-based cross-sectional study involved 7301 aged 6 years and aged 12 years children. Maternal exposure to solar irradiation during pregnancy was evaluated using data from weather stations closest to each child's birthplace. Monthly average solar irradiation during the second and third trimesters was calculated with rank by quartiles. Risks of allergic sensitization and allergic disease were estimated. Relative to the first (lowest) quartile, the adjusted odds ratio (aOR) for allergic sensitization in the fourth (highest) quartile was lowest within solar irradiation during pregnancy months 5-6 (aOR = 0.823, 95% CI 0.720-0.942, p solar irradiation (aOR = 1.167, 95% CI 1.022-1.333, p solar irradiation was analyzed as a continuous variable during months 5 (aOR = 0.975, 95% CI 0.962-0.989, p solar irradiation during months 7-8 increased the risk of asthma (aOR = 1.309, 95% CI 1.024-1.674, p = 0.032). Maternal exposure to solar irradiation during the second trimester of pregnancy associated with reduced aeroallergen sensitization, whereas solar irradiation during the third trimester was related to increased sensitization to aeroallergens. Copyright © 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.

  20. Explaining the amount of care needed by hospitalised surgical patients: a prospective time and motion study

    NARCIS (Netherlands)

    van Oostveen, Catharina J.; Vermeulen, Hester; Gouma, Dirk J.; Bakker, Piet J.; Ubbink, Dirk T.

    2013-01-01

    Hospitals provide care for patients with a variety of diseases, co-morbidities and complications. The actual amount of care these patients need is unclear. Given the recent developments such as ageing, multi-morbidity and budgetary restraints, a practical explanatory model would avail healthcare

  1. The Origin and Time Dependence of the Amount and Composition of Non-Constituent Gases Present in Crystal Growth Systems

    Science.gov (United States)

    Palosz, Witold

    1998-01-01

    Presence of different, non-constituent gases may be a critical factor in crystal growth systems. In Physical Vapor Transport processes the cras(es) can be used intentionally (to prevent excessively high, unstable growth conditions), or can evolve unintentionally during the course of the process (which may lead to undesired reduction in the -rowth rate). In melt growth, particularly under low gravity conditions (reduced hydrostatic pressure) the gas present in the system may contribute to formation of voids in the growing crystals and even to a separation of the crystal and the liquid phase [1]. On the other hand, some amount of gas may facilitate 'contactless' crystal growth particularly under reduced gravity conditions [2 - 6]. Different non-constituent gases may be present in growth ampoules, and their amount and composition may change during the crystallization process. Some gases can appear even in empty ampoules sealed originally under high vacuum: they may diffuse in from the outside, and/or desorb from the ampoule walls. Residual gases can also be generated by the source materials: even very high purity commercial elements and compounds may contain trace amounts of impurities, particularly oxides. The oxides may have low volatilities themselves but their reaction with other species, particularly carbon and hydrogen, may produce volatile compounds like water or carbon oxides. The non-constituent gases, either added initially to the system or evolved during the material processing, may diffuse out of the ampoule during the course of the experiment. Gases present outside (e.g. as a protective atmosphere or thermal conductor) may diffuse into the ampoule. In either case the growth conditions and the quality of the crystals may be affected. The problem is of a particular importance in sealed systems where the amount of the gases cannot be directly controlled. Therefore a reasonable knowledge and understanding of the origin, composition, magnitude, and change with

  2. Amount of prenatal visual stimulation alters incubation times and postnatal preferences in leopard geckos (Eublepharis macularius).

    Science.gov (United States)

    Sleigh, M J; Birchard, G F

    2001-09-01

    The authors exposed gecko (Eublepharis macularius) embryos to patterned visual stimulation beginning at either 1 week or 2 weeks prior to hatching. Embryos exposed to the substantially augmented amount of prenatal visual stimulation hatched significantly earlier than the embryos either exposed to the moderately augmented prenatal visual stimulation or not exposed to any prenatal visual stimulation (p geckos in all conditions failed to exhibit a preference for either stimulus.

  3. Statistical analysis of hydrological response in urbanising catchments based on adaptive sampling using inter-amount times

    Science.gov (United States)

    ten Veldhuis, Marie-Claire; Schleiss, Marc

    2017-04-01

    Urban catchments are typically characterised by a more flashy nature of the hydrological response compared to natural catchments. Predicting flow changes associated with urbanisation is not straightforward, as they are influenced by interactions between impervious cover, basin size, drainage connectivity and stormwater management infrastructure. In this study, we present an alternative approach to statistical analysis of hydrological response variability and basin flashiness, based on the distribution of inter-amount times. We analyse inter-amount time distributions of high-resolution streamflow time series for 17 (semi-)urbanised basins in North Carolina, USA, ranging from 13 to 238 km2 in size. We show that in the inter-amount-time framework, sampling frequency is tuned to the local variability of the flow pattern, resulting in a different representation and weighting of high and low flow periods in the statistical distribution. This leads to important differences in the way the distribution quantiles, mean, coefficient of variation and skewness vary across scales and results in lower mean intermittency and improved scaling. Moreover, we show that inter-amount-time distributions can be used to detect regulation effects on flow patterns, identify critical sampling scales and characterise flashiness of hydrological response. The possibility to use both the classical approach and the inter-amount-time framework to identify minimum observable scales and analyse flow data opens up interesting areas for future research.

  4. Boreal Forests Sequester Large Amounts of Mercury over Millennial Time Scales in the Absence of Wildfire.

    Science.gov (United States)

    Giesler, Reiner; Clemmensen, Karina E; Wardle, David A; Klaminder, Jonatan; Bindler, Richard

    2017-03-07

    Alterations in fire activity due to climate change and fire suppression may have profound effects on the balance between storage and release of carbon (C) and associated volatile elements. Stored soil mercury (Hg) is known to volatilize due to wildfires and this could substantially affect the land-air exchange of Hg; conversely the absence of fires and human disturbance may increase the time period over which Hg is sequestered. Here we show for a wildfire chronosequence spanning over more than 5000 years in boreal forest in northern Sweden that belowground inventories of total Hg are strongly related to soil humus C accumulation (R 2 = 0.94, p millennial time scales in the prolonged absence of fire.

  5. A study of the predictive model on the user reaction time using the information amount and its similarity

    International Nuclear Information System (INIS)

    Lee, Sung Jin; Heo, Gyun Young; Chang, Soon Heung

    2004-01-01

    There are lots of studies on the user interface evaluation since it started. Recent studies focus on the contextual information of the user interface. We knew that the user reaction time increases as the amount of information increases. But, the relation between the contextual information and the user reaction time may be unknown. In this study, we proposed the similarity as one of the contextual information. We can expect that the similarity decreases the user reaction time. The goal of this study is to find some correlation about the user reaction time with both the information amount and the similarity. The experiment was performed with 20 participants. The results of experiment demonstrated our proposals

  6. Amount and timing of permafrost carbon release in response to climate warming

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, Kevin; Zhang, Tingjun; Barrett, Andrew P. (National Snow and Ice Data Center, Cooperative Inst. for Research in Environmental Sciences, Univ. of Colorado at Boulder, Boulder (United States)), e-mail: kevin.schaefer@nsidc.org; Bruhwiler, Lori (National Oceanic and Atmospheric Administration, Earth System Research Laboratory, Boulder (United States))

    2011-04-15

    The thaw and release of carbon currently frozen in permafrost will increase atmospheric CO{sub 2} concentrations and amplify surface warming to initiate a positive permafrost carbon feedback (PCF) on climate.We use surface weather from three global climate models based on the moderate warming, A1B Intergovernmental Panel on Climate Change emissions scenario and the SiBCASA land surface model to estimate the strength and timing of the PCF and associated uncertainty. By 2200, we predict a 29-59% decrease in permafrost area and a 53-97 cm increase in active layer thickness. By 2200, the PCF strength in terms of cumulative permafrost carbon flux to the atmosphere is 190 +- 64 Gt C. This estimate may be low because it does not account for amplified surface warming due to the PCF itself and excludes some discontinuous permafrost regions where SiBCASA did not simulate permafrost. We predict that the PCF will change the arctic from a carbon sink to a source after the mid-2020s and is strong enough to cancel 42-88% of the total global land sink. The thaw and decay of permafrost carbon is irreversible and accounting for the PCF will require larger reductions in fossil fuel emissions to reach a target atmospheric CO{sub 2} concentration

  7. Real-time directional wave data collection

    Digital Repository Service at National Institute of Oceanography (India)

    AshokKumar, K.; Diwan, S.G.; Pednekar, P.S.

    The wave measurements carried out along the east and west coasts off India at 13 locations using the directional waverider buoys are referred in this paper. The total number of buoy days are 4501 and out of which the data collected are 4218 days...

  8. Research Directions in Real-Time Systems.

    Science.gov (United States)

    1996-09-01

    This report summarizes a survey of published research in real time systems . Material is presented that provides an overview of the topic, focusing on...communications protocols and scheduling techniques. It is noted that real - time systems deserve special attention separate from other areas because of...formal tools for design and analysis of real - time systems . The early work on applications as well as notable theoretical advances are summarized

  9. Influence of the timing of cardiac catheterization and amount of contrast media on acute renal failure after cardiac surgery.

    Science.gov (United States)

    Sadeghi, Mohsen Mirmohammad; Gharipour, Mojgan; Nilforoush, Peiman; Shamsolkotabi, Hamid; Sadeghi, Hamid Mirmohammad; Kiani, Amjad; Sadeghi, Pouya Mirmohammad; Farahmand, Niloufar

    2011-04-01

    There is limited data about the influence of timing of cardiac surgery in relation to diagnostic angiography and/or the impact of the amount of contrast media used during angiography on the occurance of acute renal failure (ARF). Therefore, in the present study the effect of the time interval between diagnostic angiography and cardiac surgery and also the amount of contrast media used during the diagnostic procedure on the incidence of ARF after cardiac surgery was investigated. Data of 1177 patients who underwent different types of cardiac surgeries after cardiac catheterization were prospectively examined. The influence of time interval between cardiac catheterization and surgery as well as the amount of contrast agent on postoperative ARF were assessed using multivariable logistic regression. The patients who progressed to ARF were more likely to have received a higher dose of contrast agent compared to the mean dose. However, the time interval between cardiac surgery and last catheterization was not significantly different between the patients with and without ARF (p = 0.05). Overall, postoperative peak creatinine was highest on day 0, then decreased and remained significantly unchanged after this period. Overall prevalence of acute renal failure during follow-up period had a changeable trend and had the highest rates in days 1 (53.57%) and 6 (52.17%) after surgery. Combined coronary bypass and valve surgery were the strongest predictor of postoperative ARF (OR: 4.976, CI = 1.613-15.355 and p = 0.002), followed by intra-aortic balloon pump insertion (OR: 6.890, CI = 1.482-32.032 and p = 0.009) and usage of higher doses of contrast media agent (OR: 1.446, CI = 1.033-2.025 and p = 0.031). Minimizing the amount of contrast agent has a potential role in reducing the incidence of postoperative ARF in patients undergoing cardiac surgery, but delaying cardiac surgery after exposure to these agents might not have this protective effect.

  10. Comparison of the Amount of Time Spent on Computer Games and Aggressive Behavior in Male Middle School Students of Tehran

    OpenAIRE

    Mehrangiz Shoaa Kazemi; Zahra Shahabinezhad

    2016-01-01

    Background and Objectives: Modern technologies have a prominent role in adolescent's daily life. These technologies include specific cultural and moral patterns, which could be highly effective on adolescents. This research aimed at comparing the amount of time spent on computer games and aggressive behavior in male middle school students of Tehran. Materials and Methods: This study had a descriptive design. The study population included all male students of middle school of Tehran, and th...

  11. Effect of increased exposure times on amount of residual monomer released from single-step self-etch adhesives.

    Science.gov (United States)

    Altunsoy, Mustafa; Botsali, Murat Selim; Tosun, Gonca; Yasar, Ahmet

    2015-10-16

    The aim of this study was to evaluate the effect of increased exposure times on the amount of residual Bis-GMA, TEGDMA, HEMA and UDMA released from single-step self-etch adhesive systems. Two adhesive systems were used. The adhesives were applied to bovine dentin surface according to the manufacturer's instructions and were polymerized using an LED curing unit for 10, 20 and 40 seconds (n = 5). After polymerization, the specimens were stored in 75% ethanol-water solution (6 mL). Residual monomers (Bis-GMA, TEGDMA, UDMA and HEMA) that were eluted from the adhesives (after 10 minutes, 1 hour, 1 day, 7 days and 30 days) were analyzed by high-performance liquid chromatography (HPLC). The data were analyzed using 1-way analysis of variance and Tukey HSD tests. Among the time periods, the highest amount of released residual monomers from adhesives was observed in the 10th minute. There were statistically significant differences regarding released Bis-GMA, UDMA, HEMA and TEGDMA between the adhesive systems (p<0.05). There were no significant differences among the 10, 20 and 40 second polymerization times according to their effect on residual monomer release from adhesives (p>0.05). Increasing the polymerization time did not have an effect on residual monomer release from single-step self-etch adhesives.

  12. Highly Sensitive GMO Detection Using Real-Time PCR with a Large Amount of DNA Template: Single-Laboratory Validation.

    Science.gov (United States)

    Mano, Junichi; Hatano, Shuko; Nagatomi, Yasuaki; Futo, Satoshi; Takabatake, Reona; Kitta, Kazumi

    2018-03-01

    Current genetically modified organism (GMO) detection methods allow for sensitive detection. However, a further increase in sensitivity will enable more efficient testing for large grain samples and reliable testing for processed foods. In this study, we investigated real-time PCR-based GMO detection methods using a large amount of DNA template. We selected target sequences that are commonly introduced into many kinds of GM crops, i.e., 35S promoter and nopaline synthase (NOS) terminator. This makes the newly developed method applicable to a wide range of GMOs, including some unauthorized ones. The estimated LOD of the new method was 0.005% of GM maize events; to the best of our knowledge, this method is the most sensitive among the GM maize detection methods for which the LOD was evaluated in terms of GMO content. A 10-fold increase in the DNA amount as compared with the amount used under common testing conditions gave an approximately 10-fold reduction in the LOD without PCR inhibition. Our method is applicable to various analytical samples, including processed foods. The use of other primers and fluorescence probes would permit highly sensitive detection of various recombinant DNA sequences besides the 35S promoter and NOS terminator.

  13. A study on the quantitative model of human response time using the amount and the similarity of information

    International Nuclear Information System (INIS)

    Lee, Sung Jin

    2006-02-01

    The mental capacity to retain or recall information, or memory is related to human performance during processing of information. Although a large number of studies have been carried out on human performance, little is known about the similarity effect. The purpose of this study was to propose and validate a quantitative and predictive model on human response time in the user interface with the basic concepts of information amount, similarity and degree of practice. It was difficult to explain human performance by only similarity or information amount. There were two difficulties: constructing a quantitative model on human response time and validating the proposed model by experimental work. A quantitative model based on the Hick's law, the law of practice and similarity theory was developed. The model was validated under various experimental conditions by measuring the participants' response time in the environment of a computer-based display. Human performance was improved by degree of similarity and practice in the user interface. Also we found the age-related human performance which was degraded as he or she was more elder. The proposed model may be useful for training operators who will handle some interfaces and predicting human performance by changing system design

  14. Influence of the timing of cardiac catheterization and amount of contrast media on acute renal failure after cardiac surgery

    Directory of Open Access Journals (Sweden)

    Mohsen Mirmohammad Sadeghi

    2011-01-01

    Full Text Available Background: There is limited data about the influence of timing of cardiac surgery in relation to diagnostic angiography and/or the impact of the amount of contrast media used during angiography on the occurance of acute renal failure (ARF. Therefore, in the present study the effect of the time interval between diagnostic angiography and cardiac surgery and also the amount of contrast media used during the diagnostic procedure on the incidence of ARF after cardiac surgery was investigated. Methods: Data of 1177 patients who underwent different types of cardiac surgeries after cardiac catheterization were prospectively examined. The influence of time interval between cardiac catheterization and surgery as well as the amount of contrast agent on postoperative ARF were assessed using multivariable logistic regression. Results: The patients who progressed to ARF were more likely to have received a higher dose of contrast agent compared to the mean dose. However, the time interval between cardiac surgery and last catheterization was not significantly different between the patients with and without ARF (p = 0.05. Overall, postoperative peak creatinine was highest on day 0, then decreased and remained significantly unchanged after this period. Overall prevalence of acute renal failure during follow-up period had a changeable trend and had the highest rates in days 1 (53.57% and 6 (52.17% after surgery. Combined coronary bypass and valve surgery were the strongest predictor of postoperative ARF (OR: 4.976, CI = 1.613-15.355 and p = 0.002, followed by intra-aortic balloon pump insertion (OR: 6.890, CI = 1.482-32.032 and p = 0.009 and usage of higher doses of contrast media agent (OR: 1.446, CI = 1.033-2.025 and p = 0.031. Conclusions: Minimizing the amount of contrast agent has a potential role in reducing the incidence of postoperative ARF in patients undergoing cardiac surgery, but delaying cardiac surgery after exposure to these agents might not have

  15. A study of the predictive model on the user reaction time using the information amount and similarity

    International Nuclear Information System (INIS)

    Lee, Sungjin; Heo, Gyunyoung; Chang, S.H.

    2004-01-01

    Human operations through a user interface are divided into two types. The one is the single operation that is performed on a static interface. The other is the sequential operation that achieves a goal by handling several displays through operator's navigation in the crt-based console. Sequential operation has similar meaning with continuous task. Most operations in recently developed computer applications correspond to the sequential operation, and the single operation can be considered as a part of the sequential operation. In the area of HCI (human computer interaction) evaluation, the Hick-Hyman law counts as the most powerful theory. The most important factor in the equation of Hick-Hyman law about choice reaction time is the quantified amount of information conveyed by a statement, stimulus, or event. Generally, we can expect that if there are some similarities between a series of interfaces, human operator is able to use his attention resource effectively. That is the performance of human operator is increased by the similarity. The similarity may be able to affect the allocation of attention resource based on separate STSS (short-term sensory store) and long-term memory. There are theories related with this concept, which are task switching paradigm and the law of practice. However, it is not easy to explain the human operator performance with only the similarity or the information amount. There are few theories to explain the performance with the combination of the similarity and the information amount. The objective of this paper is to purpose and validate the quantitative and predictive model on the user reaction time in CRT-based displays. Another objective is to validate various theories related with human cognition and perception, which are Hick-Hyman law and the law of practice as representative theories. (author)

  16. Time, Temperature and Amount of Distilled Water Effects on the Purity and Yield of Bis(2-hydroxyethyl Terephthalate Purification System

    Directory of Open Access Journals (Sweden)

    H.W. Goh

    2015-07-01

    Full Text Available Polyethylene terephthalate (PET bottle is one of the common plastic wastes existed in the municipal solid waste in Malaysia. One alternative to solve the abundant of PET wastes is chemical recycling of the wastes to produce a value added product. This technology not only can decrease the PET wastes in landfill sites but also can produce many useful recycled PET products. Bis(2-hydroxyethyl terephthalate (BHET obtained from glycolysis reaction of PET waste was purified using crystallization process. The hot distilled water was added to glycolysis product followed by cooling and filtration to extract BHET in white solid form from the product. The effect of three operating conditions namely crystallization time, crystallization temperatures and amount of distilled water used to the yield of crystallization process were investigated. The purity of crystallization products were analyzed using HPLC and DSC. The optimum conditions of 3 hours crystallization time, 2 °C crystallization temperature and 5:1 mass ratio of distilled water used to glycolize solid gave the highest yield and purity of the crystallization process. © 2015 BCREC UNDIP. All rights reservedReceived: 12nd August 2014; Revised: 4th February 2015; Accepted: 5th February 2015How to Cite: Goh, H.W., Salmiaton, A., Abdullah, N., Idris, A. (2015. Time, Temperature and Amount of Distilled Water Effects on the Purity and Yield of Bis(2-hydroxyethyl Terephthalate Purification System. Bulletin of Chemical Reaction Engineering & Catalysis, 10 (2: 143-154. (doi:10.9767/bcrec.10.2.7195.143-154 Permalink/DOI: http://dx.doi.org/10.9767/bcrec.10.2.7195.143-154  

  17. Comparison of the Amount of Time Spent on Computer Games and Aggressive Behavior in Male Middle School Students of Tehran

    Directory of Open Access Journals (Sweden)

    Mehrangiz Shoaa Kazemi

    2016-12-01

    Full Text Available Background and Objectives: Modern technologies have a prominent role in adolescent's daily life. These technologies include specific cultural and moral patterns, which could be highly effective on adolescents. This research aimed at comparing the amount of time spent on computer games and aggressive behavior in male middle school students of Tehran. Materials and Methods: This study had a descriptive design. The study population included all male students of middle school of Tehran, and the sample included 120 male students, of which 60 were dependent on computer games with aggressive behavior and 60 were non-dependent on computer games with normal behavior; the sample was randomly selected from Tehran regions (south, north, west, and east regions with random multi-stage sampling. Data were gathered using questionnaires, including Aggressive Questionnaire (AGQ and a researcher-made questionnaire consisting of 10 multiple questions that measure the use or non-use of computer games. Data were analyzed using SPSS-19 statistical software. For data analysis, Pearson correlation and t test were used. Results: The results showed that there was a meaningful relationship between computer gaming and aggressive behavior and also between duration of using computer games and aggressive behaviors (P <0.05. Conclusions: According to the results, it seems that children could be kept safe from the adverse effects of computer games by controlling the duration and the type of the games that they play.

  18. Real-Time Multi-Directional Equipment Site

    Data.gov (United States)

    Federal Laboratory Consortium — As part of the George E. Brown, Jr. Network for Earthquake Engineering Simulation (NEES) Program, Lehigh University has established the Real-Time Multi-Directional...

  19. Direct time-domain techniques for transient radiation and scattering

    International Nuclear Information System (INIS)

    Miller, E.K.; Landt, J.A.

    1976-01-01

    A tutorial introduction to transient electromagnetics, focusing on direct time-domain techniques, is presented. Physical, mathematical, numerical, and experimental aspects of time-domain methods, with emphasis on wire objects excited as antennas or scatters are examined. Numerous computed examples illustrate the characteristics of direct time-domain procedures, especially where they may offer advantages over procedures in the more familiar frequency domain. These advantages include greater solution efficiency for many types of problems, the ability to handle nonlinearities, improved physical insight and interpretability, availability of wide-band information from a single calculation, and the possibility of isolating interactions among various parts of an object using time-range gating

  20. Direct Characterization of Ultrafast Energy-Time Entangled Photon Pairs.

    Science.gov (United States)

    MacLean, Jean-Philippe W; Donohue, John M; Resch, Kevin J

    2018-02-02

    Energy-time entangled photons are critical in many quantum optical phenomena and have emerged as important elements in quantum information protocols. Entanglement in this degree of freedom often manifests itself on ultrafast time scales, making it very difficult to detect, whether one employs direct or interferometric techniques, as photon-counting detectors have insufficient time resolution. Here, we implement ultrafast photon counters based on nonlinear interactions and strong femtosecond laser pulses to probe energy-time entanglement in this important regime. Using this technique and single-photon spectrometers, we characterize all the spectral and temporal correlations of two entangled photons with femtosecond resolution. This enables the witnessing of energy-time entanglement using uncertainty relations and the direct observation of nonlocal dispersion cancellation on ultrafast time scales. These techniques are essential to understand and control the energy-time degree of freedom of light for ultrafast quantum optics.

  1. A direct electron detector for time-resolved MeV electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Vecchione, T.; Denes, P.; Jobe, R. K.; Johnson, I. J.; Joseph, J. M.; Li, R. K.; Perazzo, A.; Shen, X.; Wang, X. J.; Weathersby, S. P.; Yang, J.; Zhang, D.

    2017-03-01

    The introduction of direct electron detectors enabled the structural biology revolution of cryogenic electron microscopy. Direct electron detectors are now expected to have a similarly dramatic impact on time-resolved MeV electron microscopy, particularly by enabling both spatial and temporal jitter correction. Here we report on the commissioning of a direct electron detector for time-resolved MeV electron microscopy. The direct electron detector demonstrated MeV single electron sensitivity and is capable of recording megapixel images at 180 Hz. The detector has a 15-bit dynamic range, better than 30-μmμm spatial resolution and less than 20 analogue-to-digital converter count RMS pixel noise. The unique capabilities of the direct electron detector and the data analysis required to take advantage of these capabilities are presented. The technical challenges associated with generating and processing large amounts of data are also discussed.

  2. Shadow Education in Malaysia: Identifying the Determinants of Spending and Amount of Time Attending Private Supplementary Tutoring of Upper Secondary School Students

    Directory of Open Access Journals (Sweden)

    Chang Da Wan

    2017-10-01

    Full Text Available This paper examines the determinants of spending and the amount of time attending private supplementary tutoring, or commonly known as private tuition, in Malaysia. Based on 343 self-reported questionnaires with upper secondary students across three states in Malaysia and using multiple regression analysis, we identified ethnicity, father’s level of education and past academic performance as significant determinants of spending and amount of time attending private tuition. However, interestingly, we found that while geographical location and participation in internal tuition in schools were also determinants of spending, these two were not significant in determining the amount of time attending private supplementary tutoring. The identification of determinants of spending and amount of time, and in addition, the differences between these two illustrates the economic and educational dimensions of shadow education. More importantly, the insight also contributes to the formulation of possible interventions that can improve quality and reduce inequality in the mainstream education system.

  3. Shadow Education in Malaysia: Identifying the Determinants of Spending and Amount of Time Attending Private Supplementary Tutoring of Upper Secondary School Students

    OpenAIRE

    Chang Da Wan; Benedict Weerasena

    2017-01-01

    This paper examines the determinants of spending and the amount of time attending private supplementary tutoring, or commonly known as private tuition, in Malaysia. Based on 343 self-reported questionnaires with upper secondary students across three states in Malaysia and using multiple regression analysis, we identified ethnicity, father’s level of education and past academic performance as significant determinants of spending and amount of time attending private tuition. However, interestin...

  4. Direct output feedback control of discrete-time systems

    International Nuclear Information System (INIS)

    Lin, C.C.; Chung, L.L.; Lu, K.H.

    1993-01-01

    An optimal direct output feedback control algorithm is developed for discrete-time systems with the consideration of time delay in control force action. Optimal constant output feedback gains are obtained through variational process such that certain prescribed quadratic performance index is minimized. Discrete-time control forces are then calculated from the multiplication of output measurements by these pre-calculated feedback gains. According to the proposed algorithm, structural system is assured to remain stable even in the presence of time delay. The number of sensors and controllers may be very small as compared with the dimension of states. Numerical results show that direct velocity feedback control is more sensitive to time delay than state feedback but, is still quite effective in reducing the dynamic responses under earthquake excitation. (author)

  5. Dual-directional regulation of drug permeating amount by combining the technique of ion-pair complexation with chemical enhancers for the synchronous permeation of indapamide and bisoprolol in their compound patch through rabbit skin.

    Science.gov (United States)

    Song, Wenting; Cun, Dongmei; Quan, Peng; Liu, Nannan; Chen, Yang; Cui, Hongxia; Xiang, Rongwu; Fang, Liang

    2015-04-01

    To achieve the synchronous skin permeation of indapamide (IND) and bisoprolol (BSP) in their compound patch, the techniques of ion-pair complexation and chemical enhancers were combined to dual-directionally regulate drug permeating amounts. Ion-pair complexes of BSP and various organic acids were formed by the technique of ion-pair complexation. Among the complexes formed, bisoprolol tartrate (BSP.T) down-regulated the permeating amount of BSP to the same extent as that of IND. Then, to simultaneously up-regulate the amounts of the two drugs, an enhancer combination of 15.8% Span80 (SP), 6.0% Azone (AZ) and 2.2% N-methyl pyrrolidone (NMP) was obtained by central composite design and exhibited an outstanding and simultaneous enhancement on IND and BSP with enhancing ratio (ER) of 4.52 and 3.49, respectively. The effect of the dual-directional regulation was evaluated by in vitro permeation experiments and in vivo pharmacokinetic studies. For IND and BSP, their observed permeation profiles were comparable and their MAT (mean absorption time) showed no significant difference, which both demonstrated these two drugs achieved the synchronous skin permeation in their compound patch by the dual-directional regulation strategy of combining the technique of ion-pair complexation with chemical enhancers. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Maximizing time from the constraining European Working Time Directive (EWTD): The Heidelberg New Working Time Model.

    Science.gov (United States)

    Schimmack, Simon; Hinz, Ulf; Wagner, Andreas; Schmidt, Thomas; Strothmann, Hendrik; Büchler, Markus W; Schmitz-Winnenthal, Hubertus

    2014-01-01

    The introduction of the European Working Time Directive (EWTD) has greatly reduced training hours of surgical residents, which translates into 30% less surgical and clinical experience. Such a dramatic drop in attendance has serious implications such compromised quality of medical care. As the surgical department of the University of Heidelberg, our goal was to establish a model that was compliant with the EWTD while avoiding reduction in quality of patient care and surgical training. We first performed workload analyses and performance statistics for all working areas of our department (operation theater, emergency room, specialized consultations, surgical wards and on-call duties) using personal interviews, time cards, medical documentation software as well as data of the financial- and personnel-controlling sector of our administration. Using that information, we specifically designed an EWTD-compatible work model and implemented it. Surgical wards and operating rooms (ORs) were not compliant with the EWTD. Between 5 pm and 8 pm, three ORs were still operating two-thirds of the time. By creating an extended work shift (7:30 am-7:30 pm), we effectively reduced the workload to less than 49% from 4 pm and 8 am, allowing the combination of an eight-hour working day with a 16-hour on call duty; thus, maximizing surgical resident training and ensuring patient continuity of care while maintaining EDTW guidelines. A precise workload analysis is the key to success. The Heidelberg New Working Time Model provides a legal model, which, by avoiding rotating work shifts, assures quality of patient care and surgical training.

  7. A simple and fast determination of microgram thorium in organic solution containing several hundreds times amount of uranium

    International Nuclear Information System (INIS)

    Yin Duanzhi; Cao Benhong; Yang Jinfeng

    1991-01-01

    Using spectrophotometric method, microgram thorium in 30% TBP-kerosene system containing large amount of uranium was successfully determined after one-step back-extraction with hydrochloric acid. The recovery of thorium is more than 98%, and the separation factor α U/Th is over 1 x 10 3 . Being reliable, simple and fast, the recommended method has been used in the research on spent fuel reprocessing and is expected applicable to other neutral phosphate extraction systems such as TOPO and DMHMP

  8. Financial Time Series Forecasting Using Directed-Weighted Chunking SVMs

    Directory of Open Access Journals (Sweden)

    Yongming Cai

    2014-01-01

    Full Text Available Support vector machines (SVMs are a promising alternative to traditional regression estimation approaches. But, when dealing with massive-scale data set, there exist many problems, such as the long training time and excessive demand of memory space. So, the SVMs algorithm is not suitable to deal with financial time series data. In order to solve these problems, directed-weighted chunking SVMs algorithm is proposed. In this algorithm, the whole training data set is split into several chunks, and then the support vectors are obtained on each subset. Furthermore, the weighted support vector regressions are calculated to obtain the forecast model on the new working data set. Our directed-weighted chunking algorithm provides a new method of support vectors decomposing and combining according to the importance of chunks, which can improve the operation speed without reducing prediction accuracy. Finally, IBM stock daily close prices data are used to verify the validity of the proposed algorithm.

  9. European Working Time Directive: implications for surgical training.

    LENUS (Irish Health Repository)

    Donohoe, C L

    2010-02-01

    The forthcoming implementation of the European Working Time Directive (EWTD) for non-consultant hospital doctors (NCHDs) poses a number of challenges in the areas of patient care, training, service provision and quality of life for workers. Surgery, as a craft-based speciality, will face a greater impact on training of future surgeons as operating time could be lost to service provision. The EWTD acts a stimulus for reform of current working practices and re-configuration of services. It will necessitate transformation of the way in which surgeons are trained, if current standards are to be maintained.

  10. Influence of ripening time on the amount of certain biogenic amines in rind and core of cow milk Livno cheese

    Directory of Open Access Journals (Sweden)

    Antonela Marijan

    2014-09-01

    Full Text Available Determining the levels of biogenic amines in cheese except that it has significance for determining the nutritional value and hygienic accuracy, cheese as food can be used as a parameter to evaluate the conditions of production and/or ripening of products, and particularly in the selection of bacterial cultures. The purpose of this paper was to determine the effect of the ripening process on the amount of biogenic amines in cheese. For this purpose were conducted physico-chemical analysis, determination of biogenic amines and microbiological analysis. During the process of ripening Livno cheese from three different batches was taken one cheese from prime day and 9th, 20th, 29th, 50th, 60th and 105th day. From each cheese two samples were taken, one from the middle and one from the cheese rind. During 105th day of ripening Livno cheese, the presence of triptamin, ß-feniletlamine, putrescine, cadaverine, histamine, tyramine, spermine and spermidine were determinated. The maximum total values of searched biogenic amines were found 105th day, in the middle 184.13 mg/kg and 76.26 mg/kg in the rind of cheese. With an indication that the largest share of value rep¬resent histamine with 43.9 % and tyramine with 38.2 % in the middle, respectively histamine with 31.6 % and tyramine with 31.5 % in the rind of cheese. The values of putrescine and spermine were in small ranges and they are not identified in all samples. The values of histamine and tyramine are almost a third more at 105th than 60th day. There was a significant difference between the middle and the rind of cheese in the values of biogenic amines. Correlation between biogenic amines and microorganisms has not been determined.

  11. Versatile directional searches for gravitational waves with Pulsar Timing Arrays

    Science.gov (United States)

    Madison, D. R.; Zhu, X.-J.; Hobbs, G.; Coles, W.; Shannon, R. M.; Wang, J. B.; Tiburzi, C.; Manchester, R. N.; Bailes, M.; Bhat, N. D. R.; Burke-Spolaor, S.; Dai, S.; Dempsey, J.; Keith, M.; Kerr, M.; Lasky, P.; Levin, Y.; Osłowski, S.; Ravi, V.; Reardon, D.; Rosado, P.; Spiewak, R.; van Straten, W.; Toomey, L.; Wen, L.; You, X.

    2016-02-01

    By regularly monitoring the most stable millisecond pulsars over many years, pulsar timing arrays (PTAs) are positioned to detect and study correlations in the timing behaviour of those pulsars. Gravitational waves (GWs) from supermassive black hole binaries (SMBHBs) are an exciting potentially detectable source of such correlations. We describe a straightforward technique by which a PTA can be `phased-up' to form time series of the two polarization modes of GWs coming from a particular direction of the sky. Our technique requires no assumptions regarding the time-domain behaviour of a GW signal. This method has already been used to place stringent bounds on GWs from individual SMBHBs in circular orbits. Here, we describe the methodology and demonstrate the versatility of the technique in searches for a wide variety of GW signals including bursts with unmodelled waveforms. Using the first six years of data from the Parkes Pulsar Timing Array, we conduct an all-sky search for a detectable excess of GW power from any direction. For the lines of sight to several nearby massive galaxy clusters, we carry out a more detailed search for GW bursts with memory, which are distinct signatures of SMBHB mergers. In all cases, we find that the data are consistent with noise.

  12. Relations between Age, Autism Severity, Behavioral Treatment and the Amount of Time in Regular Education Classrooms among Students with Autism

    Science.gov (United States)

    Talib, Tasneem L.

    2012-01-01

    Under federal law, students with disabilities have the right to be educated in classrooms with students without disabilities. For students with autism, social, communication, and behavioral deficits make inclusion difficult. The severity of deficits change over time, and therefore, so too do the effects of these deficits upon inclusion. Although…

  13. Road transport working time directive: self-employed and night time provision

    NARCIS (Netherlands)

    Goudswaard, A.; Kuipsers, B.; Schoenmaker, N.; Houtman, I.L.D.; Jettinghoff, K.; Ruijs, P.A.J.; Savenije, W.M.; Osinga, D.S.C.; Koomen, M.

    2006-01-01

    On 23 March 2005, Directive 2002/15/EC concerning the organization of working time of persons performing mobile road transport activities came into force for mobile workers. Self-employed are temporally excluded from the scope of this Directive. Firstly, this report describes the implementation of

  14. Magnetosheath Propagation Time of Solar Wind Directional Discontinuities

    Science.gov (United States)

    Samsonov, A. A.; Sibeck, D. G.; Dmitrieva, N. P.; Semenov, V. S.; Slivka, K. Yu.; Å afránkova, J.; Němeček, Z.

    2018-05-01

    Observed delays in the ground response to solar wind directional discontinuities have been explained as the result of larger than expected magnetosheath propagation times. Recently, Samsonov et al. (2017, https://doi.org/10.1002/2017GL075020) showed that the typical time for a southward interplanetary magnetic field (IMF) turning to propagate across the magnetosheath is 14 min. Here by using a combination of magnetohydrodynamic simulations, spacecraft observations, and analytic calculations, we study the dependence of the propagation time on solar wind parameters and near-magnetopause cutoff speed. Increases in the solar wind speed result in greater magnetosheath plasma flow velocities, decreases in the magnetosheath thickness and, as a result, decreases in the propagation time. Increases in the IMF strength result in increases in the magnetosheath thickness and increases in the propagation time. Both magnetohydrodynamic simulations and observations suggest that propagation times are slightly smaller for northward IMF turnings. Magnetosheath flow deceleration must be taken into account when predicting the arrival times of solar wind structures at the dayside magnetopause.

  15. Energy expended and knee joint load accumulated when walking, running, or standing for the same amount of time.

    Science.gov (United States)

    Miller, Ross H; Edwards, W Brent; Deluzio, Kevin J

    2015-01-01

    Evidence suggests prolonged bouts of sitting are unhealthy, and some public health messages have recently recommended replacing sitting with more standing. However, the relative benefits of replacing sitting with standing compared to locomotion are not known. Specifically, the biomechanical consequences of standing compared to other sitting-alternatives like walking and running are not well known and are usually not considered in studies on sitting. We compared the total knee joint load accumulated (TKJLA) and the total energy expended (TEE) when performing either walking, running, or standing for a common exercise bout duration (30 min). Walking and running both (unsurprisingly) had much more TEE than standing (+300% and +1100%, respectively). TKJLA was similar between walking and standing and 74% greater in running. The results suggest that standing is a poor replacement for walking and running if one wishes to increases energy expenditure, and may be particularly questionable for use in individuals at-risk for knee osteoarthritis due to its surprisingly high TKJLA (just as high as walking, 56% of the load in running) and the type of loading (continuous compression) it places on cartilage. However, standing has health benefits as an "inactivity interrupter" that extend beyond its direct energy expenditure. We suggest that future studies on standing as an inactivity intervention consider the potential biomechanical consequences of standing more often throughout the day, particularly in the case of prolonged bouts of standing. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Relationship between Amount of Exited Blood During Wet-cupping with Patient’s Individual Conditions and the Time of Doing it

    Directory of Open Access Journals (Sweden)

    Ghazanfari M

    2017-12-01

    Full Text Available Aims Wet-cupping as a therapeutic method has been recommended to be done on certain days based on authentic sources of traditional medicine in Iran. The purpose of this study was to determine the relationship between amount of exited blood during wet-cupping with patient’s individual conditions and the time it was performed. Instruments & Methods In this descriptive cross-sectional study, 391 men who were referred to a cupping center in Saveh city in the spring of 2016, were selected by simple sampling and wet-cupping in the position between the two scapula was performed. The research instrument was a questionnaire including demographic characteristics, date of reference (day, month and year, age, height, weight and amount of exited blood during the wet-cupping in gram. Data were analyzed by SPSS 16 software and using chi-square test, paired t test and one-way analysis of variance. Findings The means of age, weight and body mass index were significantly related to the mean of amount of exited blood during wet-cupping (p0.05, but the amount of exited blood was higher in people with previous history of wet-cupping than those without previous history (p<0.001. Also, in people with hypertension, the amount of exited blood was higher than other treatment groups (p<0.05. Conclusion Individual characteristics such as age, weight, body mass index, cause of referral and previous history of wet-cupping affect the amount of exited blood during wet-cupping, but the time of wet-cupping (day and month does not affect the amount of exited blood.

  17. Minor amounts of plasma medium-chain fatty acids and no improved time trial performance after consuming lipids

    DEFF Research Database (Denmark)

    Vistisen, Bodil; Nybo, L.; Xu, Xuebing

    2003-01-01

    after consumption of specific structured triacylglycerol, consisting of a mixture of medium-chain fatty acids and long-chain fatty acids, to prevent the adverse effects observed by MCT (pure medium-chain fatty acids) regarding gastrointestinal distress. Seven well-trained subjects cycled 3 h at 55......% of maximum 02 uptake during which they ingested CHO or CHO plus specific structured triacylglycerols. Immediately after the constant-load cycling, the subjects performed a time trial of similar to50-min duration. Breath and blood samples were obtained regularly during the experiment. Fatty acid composition...... of plasma triacylglycerols, fatty acids, and phospholipids was determined. Performance was similar after administration of CHO plus specific structured triacylglycerol [medium-, long-, and medium-chain fatty acid (MLM)] compared with CHO (50.0 +/- 1.8 and 50.8 +/- 3.6 min, respectively). No plasma 8...

  18. Directional short-time Fourier transform of distributions

    Directory of Open Access Journals (Sweden)

    Katerina Hadzi-Velkova Saneva

    2016-04-01

    Full Text Available Abstract In this paper we consider the directional short-time Fourier transform (DSTFT that was introduced and investigated in (Giv in J. Math. Anal. Appl. 399:100-107, 2013. We analyze the DSTFT and its transpose on test function spaces S ( R n $\\mathcal {S}(\\mathbb {R}^{n}$ and S ( Y 2 n $\\mathcal {S}(\\mathbb {Y}^{2n}$ , respectively, and prove the continuity theorems on these spaces. Then the obtained results are used to extend the DSTFT to spaces of distributions.

  19. THE MAXIMUM AMOUNTS OF RAINFALL FALLEN IN SHORT PERIODS OF TIME IN THE HILLY AREA OF CLUJ COUNTY - GENESIS, DISTRIBUTION AND PROBABILITY OF OCCURRENCE

    Directory of Open Access Journals (Sweden)

    BLAGA IRINA

    2014-03-01

    Full Text Available The maximum amounts of rainfall are usually characterized by high intensity, and their effects on the substrate are revealed, at slope level, by the deepening of the existing forms of torrential erosion and also by the formation of new ones, and by landslide processes. For the 1971-2000 period, for the weather stations in the hilly area of Cluj County: Cluj- Napoca, Dej, Huedin and Turda the highest values of rainfall amounts fallen in 24, 48 and 72 hours were analyzed and extracted, based on which the variation and the spatial and temporal distribution of the precipitation were analyzed. The annual probability of exceedance of maximum rainfall amounts fallen in short time intervals (24, 48 and 72 hours, based on thresholds and class values was determined, using climatological practices and the Hyfran program facilities.

  20. Contrast enhancement technique in brain 3D-CTA studies. Optimizing the amount of contrast medium according to scan time based on TDC

    International Nuclear Information System (INIS)

    Terasawa, Kazuaki; Hatcho, Atsushi

    2008-01-01

    In three-dimensional CT angiography (3D-CTA), good reproducibility can be obtained by maintaining the maximum CT numbers (HU) at a specified level. However, the correlation between the scan time and the injection time showed that the maximum CT numbers increased and varied due to the additional contrast enhancement effect from recirculation of the injected contrast medium for longer injection times when the dose of iodinated contrast medium per unit time (mgI/s) was maintained at a specified level based on the time-density curve (TDC) of the phantom. The amount of contrast medium employed at our hospital has been optimized based on an iodinated contrast medium dose per unit time providing a contrast enhancement effect of 300 HU in the middle cerebral artery. Using this standard, a TDC phantom was employed to obtain an iodinated contrast medium dose per unit time, permitting equivalent maximum CT values (used as standard values) to be obtained by changing the injection time. A contrast-enhancement technique that accounts for the variation in the scan time was evaluated. Strong correlations were observed between the scan time and the injection time (R 2 =0.969) and between the injection time and the dose of iodinated contrast medium per unit body weight (R 2 =0.994). We conclude that adjusting the dose of iodinated contrast medium per unit body weight per unit time according to the scan time permits optimization of the contrast-enhancement technique. (author)

  1. Interarrival times of message propagation on directed networks

    Science.gov (United States)

    Mihaljev, Tamara; de Arcangelis, Lucilla; Herrmann, Hans J.

    2011-08-01

    One of the challenges in fighting cybercrime is to understand the dynamics of message propagation on botnets, networks of infected computers used to send viruses, unsolicited commercial emails (SPAM) or denial of service attacks. We map this problem to the propagation of multiple random walkers on directed networks and we evaluate the interarrival time distribution between successive walkers arriving at a target. We show that the temporal organization of this process, which models information propagation on unstructured peer to peer networks, has the same features as SPAM reaching a single user. We study the behavior of the message interarrival time distribution on three different network topologies using two different rules for sending messages. In all networks the propagation is not a pure Poisson process. It shows universal features on Poissonian networks and a more complex behavior on scale free networks. Results open the possibility to indirectly learn about the process of sending messages on networks with unknown topologies, by studying interarrival times at any node of the network.

  2. A real-time monitoring and assessment method for calculation of total amounts of indoor air pollutants emitted in subway stations.

    Science.gov (United States)

    Oh, TaeSeok; Kim, MinJeong; Lim, JungJin; Kang, OnYu; Shetty, K Vidya; SankaraRao, B; Yoo, ChangKyoo; Park, Jae Hyung; Kim, Jeong Tai

    2012-05-01

    Subway systems are considered as main public transportation facility in developed countries. Time spent by people in indoors, such as underground spaces, subway stations, and indoor buildings, has gradually increased in the recent past. Especially, operators or old persons who stay in indoor environments more than 15 hr per day usually influenced a greater extent by indoor air pollutants. Hence, regulations on indoor air pollutants are needed to ensure good health of people. Therefore, in this study, a new cumulative calculation method for the estimation of total amounts of indoor air pollutants emitted inside the subway station is proposed by taking cumulative amounts of indoor air pollutants based on integration concept. Minimum concentration of individual air pollutants which naturally exist in indoor space is referred as base concentration of air pollutants and can be found from the data collected. After subtracting the value of base concentration from data point of each data set of indoor air pollutant, the primary quantity of emitted air pollutant is calculated. After integration is carried out with these values, adding the base concentration to the integration quantity gives the total amount of indoor air pollutant emitted. Moreover the values of new index for cumulative indoor air quality obtained for 1 day are calculated using the values of cumulative air quality index (CAI). Cumulative comprehensive indoor air quality index (CCIAI) is also proposed to compare the values of cumulative concentrations of indoor air pollutants. From the results, it is clear that the cumulative assessment approach of indoor air quality (IAQ) is useful for monitoring the values of total amounts of indoor air pollutants emitted, in case of exposure to indoor air pollutants for a long time. Also, the values of CCIAI are influenced more by the values of concentration of NO2, which is released due to the use of air conditioners and combustion of the fuel. The results obtained in

  3. Petroleomics by Direct Analysis in Real Time-Mass Spectrometry.

    Science.gov (United States)

    Romão, Wanderson; Tose, Lilian V; Vaz, Boniek G; Sama, Sara G; Lobinski, Ryszard; Giusti, Pierre; Carrier, Hervé; Bouyssiere, Brice

    2016-01-01

    The analysis of crude oil and its fractions by applying ambient ionization techniques remains underexplored in mass spectrometry (MS). Direct analysis in real time (DART) in the positive-ion mode was coupled to a linear quadrupole ion trap Orbitrap mass spectrometer (LTQ Orbitrap) to analyze crude oil, paraffin samples, and porphyrin standard compounds. The ionization parameters of DART-MS were optimized for crude oil analysis. DART-MS rendered the optimum conditions of the operation using paper as the substrate, T = 400°C, helium as the carrier gas, and a sample concentration ≥6 mg mL(-1). In the crude oils analysis, the DART(+)-Orbitrap mass spectra detected the typical N, NO, and O-containing compounds. In the paraffin samples, oxidized hydrocarbon species (Ox classes, where x = 1-4) with double-bond equivalent of 1-4 were detected, and their structures and connectivity were confirmed by collision-induced dissociation (CID) experiments. DART(+)-MS has identified the porphyrin standard compounds as [M + H](+) ions of m/z 615.2502 and 680.1763, where M = C44H30N4 and C44H28N4OV, respectively, based on the formula assignment and by phenyl losses observed on CID experiments.

  4. First direct observation of time-reversal violation

    International Nuclear Information System (INIS)

    Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Bertin, V.; Ealet, A.; Henry-Couannier, F.; Le Gac, R.; Montanet, F.; Touchard, F.; Backenstoss, G.; Benelli, A.; Kokkas, P.; Leimgruber, F.; Pavlopoulos, P.; Polivka, G.; Rickenbach, R.; Schietinger, T.; Tauscher, L.; Vlachos, S.; Bargassa, P.

    2000-01-01

    Using its unique capability of strangeness tagging at K 0 production in pp-bar→K ± π ± K 0 (K-bar) 0 ) and at decay with the lepton charge in semileptonic decays CPLEAR measured the semileptonic decay-rate asymmetry (R(K-bar) 0 →e + π - ν)-R(K 0 →e - π + ν-bar)/R(K-bar) 0 →e + π - ν)+R(K 0 →e - π + ν-bar). The asymmetry, fitted over the eigentime interval 1-20 τ S , yielded a non-zero result of (6.6±1.3 stat ±1.1 syst )x10 -3 . A thorough phenomenological analysis identifies T violation in K 0 mixing and/or CPT violation in semileptonic decays as possible interpretations. A confrontation with world data on neutral kaon decays, however, excludes the latter with sufficient precision to establish the result as the first direct observation of time reversal non-invariance

  5. BOOK REVIEW: The Physical Basis of the Direction of Time

    Science.gov (United States)

    Giulini, Domenico

    2008-10-01

    This is the fifth edition of H Dieter Zeh's classic text on the physical foundations of time-irreversibility in the phenomena. A forerunner of this book was the 1984 German text 'Die Physik der Zeitrichtung' of about 80 pages, which appeared as volume 200 in the Springer series Lecture Notes in Physics. It was soon followed by a largely revised and extended English edition of about twice the length. Since then each new edition has been thoroughly revised and, edition by edition, new topics and chapters have been added. As the author says in the introduction: 'The prime intention of this book is to discuss the relations between various arrows of time, and to search for a universal master arrow'. Correspondingly, after a short chapter on 'the physical concept of time', the author systematically discusses in the remaining five chapters the time arrows in electromagnetic radiation theory, in thermodynamics, in quantum mechanics, in black-hole physics and cosmology, and in quantum cosmology. The chapters on thermodynamics and quantum mechanics slightly outweigh the others in terms of length. The fifth edition now includes two new section on 'cosmic probabilities and history' and 'quantum computers', and the section on the 'expansion of the universe' has been restructured and extended. Other changes concentrate on the sections on radiation damping, decoherence, interpretation of quantum theory, and quantum cosmology. It should also be mentioned that the author maintains a regularly updated website for the book at www.time-direction.de. The reading is always highly stimulating and uses results and ideas from a very broad range of physics, with interspersed historical and philosophical comments. Somehow outstanding and of particular interest is the chapter on quantum cosmology, which raises novel interpretational issues that cannot be found in any other textbook I know of on time asymmetry. As regards the mathematical prerequisites, the reader is assumed to have some

  6. The Amount of Time to Eat Lunch is Associated with Children’s Selection and Consumption of School Meal Entrée, Fruits, Vegetable, and Milk

    Science.gov (United States)

    Cohen, Juliana F.W.; Jahn, Jaquelyn L.; Richardson, Scott; Cluggish, Sarah A.; Parker, Ellen; Rimm, Eric B.

    2015-01-01

    Background There are currently no national standards for school lunch period lengths and little is known about the association between the amount of time students have to eat and school food selection and consumption. Objectives To examine plate waste measurements from students in the control arm from the MEALS study (2011-2012 school year) for the association of the amount of time to eat with school meal selection and consumption. Design Prospective study using up to six repeated measures among students over the school year. Participants/Setting 1001 students in grades 3-8 attending 6 participating elementary/middle schools in an urban, low-income school district where lunch period lengths varied from 20-30 minutes. Main Outcome Measures School food selection and consumption were collected using plate waste methodology. Statistical Analyses Performed Logistic regression and mixed-model ANOVA was used to examine food selection and consumption. Results Compared with meal component selection when students had at least 25 minutes to eat, students were significantly less likely to select a fruit (44% vs. 57%; p=0.0001) compared with when students had fewer than 20 minutes to eat. There were no significant differences in entrée, milk, or vegetable selection. Among those who selected a meal component, students with fewer than 20 minutes to eat consumed 13% less of their entrée (peat. Conclusions Over the school year, a substantial number of students had insufficient time to eat, which was associated with significantly decreased entrée, milk, and vegetable consumption compared with students who had more time to eat. School policies that encourage lunches with at least 25 minutes of seated time may reduce food waste and improve dietary intake. PMID:26372337

  7. Amount of Time to Eat Lunch Is Associated with Children's Selection and Consumption of School Meal Entrée, Fruits, Vegetables, and Milk.

    Science.gov (United States)

    Cohen, Juliana F W; Jahn, Jaquelyn L; Richardson, Scott; Cluggish, Sarah A; Parker, Ellen; Rimm, Eric B

    2016-01-01

    There are currently no national standards for school lunch period length and little is known about the association between the amount of time students have to eat and school food selection and consumption. Our aim was to examine plate-waste measurements from students in the control arm of the Modifying Eating and Lifestyles at School study (2011 to 2012 school year) to determine the association between amount of time to eat and school meal selection and consumption. We used a prospective study design using up to six repeated measures among students during the school year. One thousand and one students in grades 3 to 8 attending six participating elementary and middle schools in an urban, low-income school district where lunch period lengths varied from 20 to 30 minutes were included. School food selection and consumption were collected using plate-waste methodology. Logistic regression and mixed-model analysis of variance was used to examine food selection and consumption. Compared with meal-component selection when students had at least 25 minutes to eat, students were significantly less likely to select a fruit (44% vs 57%; Peat. There were no significant differences in entrée, milk, or vegetable selections. Among those who selected a meal component, students with eat consumed 13% less of their entrée (Peat. During the school year, a substantial number of students had insufficient time to eat, which was associated with significantly decreased entrée, milk, and vegetable consumption compared with students who had more time to eat. School policies that encourage lunches with at least 25 minutes of seated time might reduce food waste and improve dietary intake. Copyright © 2016 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  8. Preoperative management of surgical patients by "shortened fasting time": a study on the amount of total body water by multi-frequency impedance method.

    Science.gov (United States)

    Taniguchi, Hideki; Sasaki, Toshio; Fujita, Hisae

    2012-01-01

    Preoperative fasting is an established procedure to be practiced for patients before surgery, but optimal preoperative fasting time still remains controversial. The aim of this study was to investigate the effect of "shortened preoperative fasting time" on the change in the amount of total body water (TBW) in elective surgical patients. TBW was measured by multi-frequency impedance method. The patients, who were scheduled to undergo surgery for stomach cancer, were divided into two groups of 15 patients each. Before surgery, patients in the control group were managed with conventional preoperative fasting time, while patients in the "enhanced recovery after surgery (ERAS)" group were managed with "shortened preoperative fasting time" and "reduced laxative medication." TBW was measured on the day before surgery and the day of surgery before entering the operating room. Defecation times and anesthesia-related vomiting and aspiration were monitored. TBW values on the day of surgery showed changes in both groups as compared with those on the day before surgery, but the rate of change was smaller in the ERAS group than in the control group (2.4±6.8% [12 patients] vs. -10.6±4.6% [14 patients], pfasting time" and "reduced administration of laxatives" is effective in the maintenance of TBW in elective surgical patients.

  9. Circadian-Time Sickness: Time-of-Day Cue-Conflicts Directly Affect Health.

    Science.gov (United States)

    van Ee, Raymond; Van de Cruys, Sander; Schlangen, Luc J M; Vlaskamp, Björn N S

    2016-11-01

    A daily rhythm that is not in synchrony with the environmental light-dark cycle (as in jetlag and shift work) is known to affect mood and health through an as yet unresolved neural mechanism. Here, we combine Bayesian probabilistic 'cue-conflict' theory with known physiology of the biological clock of the brain, entailing the insight that, for a functional pacemaker, it is sufficient to have two interacting units (reflecting environmental and internal time-of-day cues), without the need for an extra homuncular directing unit. Unnatural light-dark cycles cause a time-of-day cue-conflict that is reflected by a desynchronization between the ventral (environmental) and dorsal (internal) pacemaking signals of the pacemaker. We argue that this desynchronization, in-and-of-itself, produces health issues that we designate as 'circadian-time sickness', analogous to 'motion sickness'. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Direct hospital marketing: an idea whose time has come.

    Science.gov (United States)

    Dodson, D C; Dotson, M J; Cussimanio, L

    1990-01-01

    Health care marketing has arrived swiftly and with significant impact upon the hospital scene. From the early days of rejection and suspicion of only a few years ago, it has now taken its place with other hospital management functions. Still, however, hospitals have not yet reached the degree of expertise that exists in other sectors. One of the reasons why hospitals have not fully emerged to the level of marketing expertise as many of their traditional business counterparts is that many of the areas of both the science and art of marketing have not been fully developed. One such area is direct mail marketing. Presented here is an overview of the advantages and functions of hospital direct mail marketing. A variety of examples are given with a more thorough case example being provided by Lee's Summit Community Hospital in Lee's Summit, Missouri. The successful direct mail marketing campaign there should be both an inspiration and a model for success for other hospitals. Space limitations prevent the authors from some of the more exacting details of mail marketing and, of course, successful campaigns do not happen by magic. They take careful planning, strategy, and execution. They also require a coordinated organizational and human effort to be successful. But direct mail marketing does offer a potentially new arena of marketing for most hospitals. The expertise, skill, knowledge, and technology are in place. All that is really needed is the commitment on the part of the hospital leadership.

  11. Effect of Timing and Amount of Irrigation Water on Bean Yield and Water Use Efficiency in Arid and Semi-arid Conditions

    Directory of Open Access Journals (Sweden)

    S.S. Nurbakhsh

    2016-02-01

    Full Text Available Introduction: Nowadays, due to lack of water resources and increasing demand for water, agricultural water planning issues need further consideration. With proper planning and determination of irrigation depth and time, the effects of stress and yield loss on the plants are reduced. Irrigation scheduling is one of the most important factors in crop’s quality and quantity. The main objective of irrigation scheduling is to control crop’s water conditions in order to achieve its optimum yield level. So irrigation timing is the vital factor on which crop water stress and eventually yield's level are dependent upon. Moreover, irrigation timing is used in irrigation scheduling. The aim of this study was to evaluate the effect of irrigation time on water consumption, water use efficiency and yield of beans. Materials and Methods: In order to observe the effect of the amount and the time of the irrigation on water consumption, yields rate and water use efficiency, the current research was carried out at the University of Shahrekord during the summer of 2012. The experiment was done as a completely randomized design with 4 repetitions consisting of irrigation time and the amount of irrigation in 4 and 2 levels (at 6, 8, 14 and 18 and (deficit irrigation, full irrigation, respectively. Beans seeds were planted in 32 similar vases with a diameter of 45 cm and height of 60 cm, in each experiment. Treatments were begun after 37 days from planting. Treatments were irrigated when the average moisture in the root zone was equal to the lower border of readily available water of full irrigation. At the end of the experiments, plants were completely harvested. Then the plant’s height, number of branches, numbers of pods per plant, pod and seed weight were measured. Results and Discussion: Results showed that irrigating at different times during the day influenced water use efficiency, water consumption, seeds yield and number of pods in the bush. The water

  12. Directional Networking in GPS Denied Environments - Time Synchronization

    Science.gov (United States)

    2016-03-14

    RF-based measurements to synchronize time and measure node range.  Satellite Doppler: Using Doppler measurements from multiple satellites along...with satellite catalog data to determine time and position.  LTE : Use existing LTE base-stations for time and position.  Differential GPS: A...Opportunistic Signals: Opportunistically take advantage of existing RF signals (i.e., FM radio, DTV, LTE , etc.) transmitted from known locations

  13. Effects of amount and timing of nitrogen application and weed density on wild mustard (Sinapis arvensis seed production in winter wheat

    Directory of Open Access Journals (Sweden)

    mehdi rastgoo

    2009-06-01

    Full Text Available In order to study the effects of amount and timing of nitrogen application and weed density on wild mustard (Sinapis arvensis seed production in winter wheat, an experiment was conducted in 2001 at Research station of college of agriculture, Ferdowsi University of Mashhad. A Split plot design with three replications were used with factorial combination of weed density (0, 8, 16, and 32 plant/m2 and nitrogen (low=100, optimum= 150, and high= 225 Kg/ha as main plots.The sub plot factor included nitrogen splitting pattern (P1=1/3 at planting time+2/3 at tillering, P2= 1/3 at planting time + 1/3 at tillering + 1/3 at shooting. According to the results, wild mustard seed production increased with increasing wild mustard density and nitrogen rates, due to high wild mustard biomass production. Seed production of wild mustard was 161, 311, and 488 million/ha in low, optimum and high nitrogen rates, respectively. In the other hand, density and nitrogen rates had a significant effect on wild mustard fecundity. However, nitrogen splitting pattern showed no significant effect on wild mustard seed production.

  14. The Relationship of Amount of Resection and Time for Recovery of Bell’s Phenomenon after Levator Resection in Congenital Ptosis

    Science.gov (United States)

    Goel, Ruchi; Kishore, Divya; Nagpal, Smriti; Jain, Sparshi; Agarwal, Tushar

    2017-01-01

    Background: Recovery of Bell`s phenomenon after levator resection is unpredicatable. Delayed recovery can result in vision threatening corneal complications. Aim: To study the variability of Bell’s phenomenon and time taken for its recovery following levator resection for blepharoptosis and to correlate it with the amount of resection. Methods: A prospective observational study was conducted on 32 eyes of 32 patients diagnosed as unilateral simple congenital blepharoptosis who underwent levator resection at a tertiary care center between July 2013 and May 2015. Patients were followed up for 5 months and correction of ptosis, type of Bell`s, duration of Bell`s recovery and complications were noted. Results: The study group ranged from 16-25 years with 15:17 male: female ratio. There were 9 mild, 16 moderate and 7 severe ptosis. Satisfactory correction was achieved in all cases. Good Bell`s recovery occurred in 13 eyes on first post-op day, in 2-14 days in 19 eyes and 28 days in 1 eye. Inverse Bell`s was noted along with lid oedema and ecchymosis in 2 patients. Large resections (23-26mm) were associated with poor Bell`s on the first postoperative day (p=0.027, Fisher`s exact test). However, the duration required for recovery of Bell`s phenomenon did not show any significant difference with the amount of resection. (p=0.248, Mann Whitney test). Larger resections resulted in greater lagophthalmos (correlation=0.830, p<0.0001). Patients with recovery of Bell`s delayed for more than 7 days were associated with greater number of complications (p=0.001 Fisher`s Exact Test). Conclusion: Close monitoring for Bell`s recovery is required following levator resection. PMID:28584563

  15. Direct Measurements of Smartphone Screen-Time: Relationships with Demographics and Sleep.

    Science.gov (United States)

    Christensen, Matthew A; Bettencourt, Laura; Kaye, Leanne; Moturu, Sai T; Nguyen, Kaylin T; Olgin, Jeffrey E; Pletcher, Mark J; Marcus, Gregory M

    2016-01-01

    Smartphones are increasingly integrated into everyday life, but frequency of use has not yet been objectively measured and compared to demographics, health information, and in particular, sleep quality. The aim of this study was to characterize smartphone use by measuring screen-time directly, determine factors that are associated with increased screen-time, and to test the hypothesis that increased screen-time is associated with poor sleep. We performed a cross-sectional analysis in a subset of 653 participants enrolled in the Health eHeart Study, an internet-based longitudinal cohort study open to any interested adult (≥ 18 years). Smartphone screen-time (the number of minutes in each hour the screen was on) was measured continuously via smartphone application. For each participant, total and average screen-time were computed over 30-day windows. Average screen-time specifically during self-reported bedtime hours and sleeping period was also computed. Demographics, medical information, and sleep habits (Pittsburgh Sleep Quality Index-PSQI) were obtained by survey. Linear regression was used to obtain effect estimates. Total screen-time over 30 days was a median 38.4 hours (IQR 21.4 to 61.3) and average screen-time over 30 days was a median 3.7 minutes per hour (IQR 2.2 to 5.5). Younger age, self-reported race/ethnicity of Black and "Other" were associated with longer average screen-time after adjustment for potential confounders. Longer average screen-time was associated with shorter sleep duration and worse sleep-efficiency. Longer average screen-times during bedtime and the sleeping period were associated with poor sleep quality, decreased sleep efficiency, and longer sleep onset latency. These findings on actual smartphone screen-time build upon prior work based on self-report and confirm that adults spend a substantial amount of time using their smartphones. Screen-time differs across age and race, but is similar across socio-economic strata suggesting that

  16. Direct Measurements of Smartphone Screen-Time: Relationships with Demographics and Sleep.

    Directory of Open Access Journals (Sweden)

    Matthew A Christensen

    Full Text Available Smartphones are increasingly integrated into everyday life, but frequency of use has not yet been objectively measured and compared to demographics, health information, and in particular, sleep quality.The aim of this study was to characterize smartphone use by measuring screen-time directly, determine factors that are associated with increased screen-time, and to test the hypothesis that increased screen-time is associated with poor sleep.We performed a cross-sectional analysis in a subset of 653 participants enrolled in the Health eHeart Study, an internet-based longitudinal cohort study open to any interested adult (≥ 18 years. Smartphone screen-time (the number of minutes in each hour the screen was on was measured continuously via smartphone application. For each participant, total and average screen-time were computed over 30-day windows. Average screen-time specifically during self-reported bedtime hours and sleeping period was also computed. Demographics, medical information, and sleep habits (Pittsburgh Sleep Quality Index-PSQI were obtained by survey. Linear regression was used to obtain effect estimates.Total screen-time over 30 days was a median 38.4 hours (IQR 21.4 to 61.3 and average screen-time over 30 days was a median 3.7 minutes per hour (IQR 2.2 to 5.5. Younger age, self-reported race/ethnicity of Black and "Other" were associated with longer average screen-time after adjustment for potential confounders. Longer average screen-time was associated with shorter sleep duration and worse sleep-efficiency. Longer average screen-times during bedtime and the sleeping period were associated with poor sleep quality, decreased sleep efficiency, and longer sleep onset latency.These findings on actual smartphone screen-time build upon prior work based on self-report and confirm that adults spend a substantial amount of time using their smartphones. Screen-time differs across age and race, but is similar across socio-economic strata

  17. Prospects for direct measurement of time-integrated Bs mixing

    International Nuclear Information System (INIS)

    Siccama, I.

    1994-01-01

    This note investigates the prospects of measuring time-integrated B s mixing. Three inclusive decay modes of the B s meson are discussed. For each reconstruction mode, the expected number of events and the different background channels are discussed. Estimates are given for the uncertainty on the mixing parameter χ s . (orig.)

  18. 5 CFR 330.504 - Special restrictions after appointment under Part-time Direct Hire Program.

    Science.gov (United States)

    2010-01-01

    ... under Part-time Direct Hire Program. 330.504 Section 330.504 Administrative Personnel OFFICE OF... To Protect Competitive Principles § 330.504 Special restrictions after appointment under Part-time Direct Hire Program. (a) A person hired under the Part-time Direct Hire Program may not be changed to...

  19. Time of default in tuberculosis patients on directly observed treatment.

    Science.gov (United States)

    Pardeshi, Geeta S

    2010-09-01

    Default remains an important challenge for the Revised National Tuberculosis Control Programme, which has achieved improved cure rates. This study describes the pattern of time of default in patients on DOTS. Tuberculosis Unit in District Tuberculosis Centre, Yavatmal, India; Retrospective cohort study. This analysis was done among the cohort of patients of registered at the Tuberculosis Unit during the year 2004. The time of default was assessed from the tuberculosis register. The sputum smear conversion and treatment outcome were also assessed. Kaplan-Meier plots and log rank tests. Overall, the default rate amongst the 716 patients registered at the Tuberculosis Unit was 10.33%. There was a significant difference in the default rate over time between the three DOTS categories (log rank statistic= 15.49, P=0.0004). Amongst the 331 smear-positive patients, the cumulative default rates at the end of intensive phase were 4% and 16%; while by end of treatment period, the default rates were 6% and 31% in category I and category II, respectively. A majority of the smear-positive patients in category II belonged to the group 'treatment after default' (56/95), and 30% of them defaulted during re-treatment. The sputum smear conversion rate at the end of intensive phase was 84%. Amongst 36 patients without smear conversion at the end of intensive phase, 55% had treatment failure. Patients defaulting in intensive phase of treatment and without smear conversion at the end of intensive phase should be retrieved on a priority basis. Default constitutes not only a major reason for patients needing re-treatment but also a risk for repeated default.

  20. Effects of sample injection amount and time-of-flight mass spectrometric detection dynamic range on metabolome analysis by high-performance chemical isotope labeling LC-MS.

    Science.gov (United States)

    Zhou, Ruokun; Li, Liang

    2015-04-06

    The effect of sample injection amount on metabolome analysis in a chemical isotope labeling (CIL) liquid chromatography-mass spectrometry (LC-MS) platform was investigated. The performance of time-of-flight (TOF) mass spectrometers with and without a high-dynamic-range (HD) detection system was compared in the analysis of (12)C2/(13)C2-dansyl labeled human urine samples. An average of 1635 ± 21 (n = 3) peak pairs or putative metabolites was detected using the HD-TOF-MS, compared to 1429 ± 37 peak pairs from a conventional or non-HD TOF-MS. In both instruments, signal saturation was observed. However, in the HD-TOF-MS, signal saturation was mainly caused by the ionization process, while in the non-HD TOF-MS, it was caused by the detection process. To extend the MS detection range in the non-HD TOF-MS, an automated switching from using (12)C to (13)C-natural abundance peaks for peak ratio calculation when the (12)C peaks are saturated has been implemented in IsoMS, a software tool for processing CIL LC-MS data. This work illustrates that injecting an optimal sample amount is important to maximize the metabolome coverage while avoiding the sample carryover problem often associated with over-injection. A TOF mass spectrometer with an enhanced detection dynamic range can also significantly increase the number of peak pairs detected. In chemical isotope labeling (CIL) LC-MS, relative metabolite quantification is done by measuring the peak ratio of a (13)C2-/(12)C2-labeled peak pair for a given metabolite present in two comparative samples. The dynamic range of peak ratio measurement does not need to be very large, as only subtle changes of metabolite concentrations are encountered in most metabolomic studies where relative metabolome quantification of different groups of samples is performed. However, the absolute concentrations of different metabolites can be very different, requiring a technique to provide a wide detection dynamic range to allow the detection of as

  1. Growth and N-uptake in sorghum plants manured with different amounts of Leucaena Leucocephala shoots as affected by time of application

    International Nuclear Information System (INIS)

    Kurdali, F.; Al-Shamma'a, M.

    2007-01-01

    A pot experiment was conducted throughout two successive years to determine the impact of adding four rates of nitrogen (0, 60, 120 and 180 kg N/ha) in the form of Leucaena leucocephala (lam.) de Wit green manure as affected by different time (T0, T15 and T30) of application (just before sowing, 15 and 30 days before sowing, respectively) on the performance of sorghum (Sorghum bicolor L.) using the indirect N-15 isotopic dilution technique. Results showed that leucaena leaves, used as a green manure, significantly increased dry matter production and N yield of sorghum. The effect was more pronounced in panicles than shoots. In the first year, N recoveries in sorghum of the total N contained in leucaena green manure ranged between 17-24% in T0, 14-24% in T15 and 15-19% in T30. The highest N recovery value was obtained in lowest rate of n treatment (N60). Moreover, soil incorporated with leucaena green manure one month before planting enhanced both soil and mineral N fertilizer in sorghum plants. In the second year, total N uptake in sorghum (eg., panicles and the entire plant) increased with increasing amounts of N added as a leucaena green manure. N recoveries in sorghum ranged between 26-47% in T0, about 24% in T15 and 23-325 in T30 of the total N contained in leucaena green manure (LGM). As shown in the first year, the highest value of N recovery was obtained in lowest rate of N treatment. The beneficial effects of leucaena green manure on dry matter and N yield in sorghum was attributed not only to the additional N availability to the plant, but also to effects on the enhancement of soil N uptake, particularly when the incorporation was made before a sufficient time from sowing. The beneficial effect of green manuring with leucaena leaves at T15 and T30 was mainly resulted from enhancement of N uptake from this added material, as well as from soil and fertilizer N. Whereas, it was only attributed to N uptake from green manure in the T0 treatment. Incorporation

  2. Growth and N-uptake in sorghum plants manured with different amounts of Leucaena Leucocephala shoots as affected by time of application

    International Nuclear Information System (INIS)

    Kurdali, F.; Al-Shamma'a, M.

    2006-08-01

    A pot experiment was conducted throughout two successive years to determine the impact of adding four rates of nitrogen (0, 60, 120 and 180 kg N/ha) in the form of Leucaena leucocephala (lam.) de Wit green manure as affected by different time (T0, T15 and T30) of application (just before sowing, 15 and 30 days before sowing, respectively) on the performance of sorghum (Sorghum bicolor L.) using the indirect N-15 isotopic dilution technique. Results showed that leucaena leaves, used as a green manure, significantly increased dry matter production and N yield of sorghum. The effect was more pronounced in panicles than shoots. In the first year, N recoveries in sorghum of the total N contained in leucaena green manure ranged between 17-24% in T0, 14-24% in T15 and 15-19% in T30. The highest N recovery value was obtained in lowest rate of n treatment (N 60 ). Moreover, soil incorporated with leucaena green manure one month before planting enhanced both soil and mineral N fertilizer in sorghum plants. In the second year, total N uptake in sorghum (eg., panicles and the entire plant) increased with increasing amounts of N added as a leucaena green manure. N recoveries in sorghum ranged between 26-47% in T0, about 24% in T15 and 23-325 in T30 of the total N contained in leucaena green manure (LGM). As shown in the first year, the highest value of N recovery was obtained in lowest rate of N treatment. The beneficial effects of leucaena green manure on dry matter and N yield in sorghum was attributed not only to the additional N availability to the plant, but also to effects on the enhancement of soil N uptake, particularly when the incorporation was made before a sufficient time from sowing. The beneficial effect of green manuring with leucaena leaves at T15 and T30 was mainly resulted from enhancement of N uptake from this added material, as well as from soil and fertilizer N; whereas, it was only attributed to N uptake from green manure in the T0 treatment. Incorporation

  3. Direct-to-physician and direct-to-consumer advertising: Time to have stringent regulations.

    Science.gov (United States)

    Kannan, S; Gowri, S; Tyagi, V; Kohli, S; Jain, R; Kapil, P; Bhardwaj, A

    2015-01-01

    Direct to physician advertisements and direct to consumer advertisement (DTCA) is a well-known marketing strategy of pharmaceutical companies. Studies from the West and also from the Indian sub-continent revealed several lacunae in such advertisements. The present study was carried out to understand the international and national scenario regarding the lacunae in drug advertisements and the opinion of both physicians and patients regarding DTCA. The present study was conducted after obtaining approval from the institutional ethics committee. Warning letters (WLs) issued to pharmaceutical companies by United States Food and Drug Administration (USFDA) and Therapeutic Goods Administration (TGA) due to discrepancies in the advertisements were analyzed for reasons that were grouped into one of the following categories: overstatement of efficacy; unapproved indication; lack of adequate directions to use; omission of adverse effects; misleading claims; advertisement made for an unapproved drug (investigational new product). Drug advertisements in Current Index of Medical Specialties (CIMS) April-July 2014 issue was also analyzed for lacunae depending on categories as mentioned above. Physicians and patients in a tertiary care medical college and hospital were administered a validated questionnaire exploring their views about crucial aspects of DTCA. Descriptive statistics was used for each of the categories. A total of 93 WLs issued by USFDA and 36 by TGA were assessed. Majority of the WLs by USFDA were issued for omission of adverse effects (61/93, 65.6%) followed by misleading claims (54/93, 58.1%). Similarly, WLs by TGA were also mainly issued for the presence of misleading claims (35/36, 97.2%) followed by overstatement of efficacy (26/36, 72.2%) and CIMS evaluation had revealed that 78/92 (84.8%) advertisements omitted adverse effects, 20/92 (21.7%) had misleading claims, 9/92 (9.8%) had unapproved indications and 7/92 (7.6%) overstated the efficacy. With regard to

  4. Immune responses in Eimeria acervulina infected one-day-old broilers compared to amount of Eimeria in the duodenum, measured by real-time PCR

    NARCIS (Netherlands)

    Swinkels, W.J.C.; Post, J.; Cornelissen, J.B.W.J.; Engel, B.; Boerma, S.; Rebel, J.M.J.

    2006-01-01

    T-cell responses are supposed to be the major immune reactions in broilers infected with Eimeria. The nature of such T-cell responses is influenced by the species of Eimeria involved, age of the host, amount of parasites and the preceding infection history. In young chicks the intestine is still

  5. Effects of direct injection timing and blending ratio on RCCI combustion with different low reactivity fuels

    International Nuclear Information System (INIS)

    Benajes, Jesús; Molina, Santiago; García, Antonio; Monsalve-Serrano, Javier

    2015-01-01

    Highlights: • E85 requires notable lower premixed energy ratios to achieve a stable combustion. • E10-95 leads to shorter and advanced combustion with higher maximum RoHR peaks. • E20-95, E10-98 and E10-95 reach EURO VI NOx and soot levels for all the engine loads. • E10-95 allows a significant reduction in HC and CO emissions. - Abstract: This work investigates the effects of the direct injection timing and blending ratio on RCCI performance and engine-out emissions at different engine loads using four low reactivity fuels: E10-95, E10-98, E20-95 and E85 (port fuel injected) and keeping constant the same high reactivity fuel: diesel B7 (direct injected). The experiments were conducted using a heavy-duty single-cylinder research diesel engine adapted for dual-fuel operation. All the tests were carried out at 1200 rpm. To assess the blending ratio effect, the total energy delivered to the cylinder coming from the low reactivity fuel was kept constant for the different fuel blends investigated by adjusting the low reactivity fuel mass as required in each case. In addition, a detailed analysis of the air/fuel mixing process has been developed by means of a 1-D in-house developed spray model. Results suggest that notable higher diesel amount is required to achieve a stable combustion using E85. This fact leads to higher NOx levels and unacceptable ringing intensity. By contrast, EURO VI NOx and soot levels are fulfilled with E20-95, E10-98 and E10-95. Finally, the higher reactivity of E10-95 results in a significant reduction in CO and HC emissions, mainly at low load

  6. Directional spectrum of ocean waves from array measurements using phase/time/path difference methods

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, A.A.; Sarma, Y.V.B.; Menon, H.B.

    Wave direction has for the first time been consistently, accurately and unambiguously evaluated from array measurements using the phase/time/path difference (PTPD) methods of Esteva in case of polygonal arrays and Borgman in case of linear arrays...

  7. Real-time aircraft continuous descent trajectory optimization with ATC time constraints using direct collocation methods.

    OpenAIRE

    Verhoeven, Ronald; Dalmau Codina, Ramon; Prats Menéndez, Xavier; de Gelder, Nico

    2014-01-01

    1 Abstract In this paper an initial implementation of a real - time aircraft trajectory optimization algorithm is presented . The aircraft trajectory for descent and approach is computed for minimum use of thrust and speed brake in support of a “green” continuous descent and approach flight operation, while complying with ATC time constraints for maintaining runway throughput and co...

  8. Analysis on the time/activity curve of salivary gland scintigraphy in salivary gland diseases; The correlation between the pattern of time/activity curve and the amount of saliva

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Kazufumi; Hosokawa, Yoichiro; Kaneko, Masanori; Ohmori, Keiichi; Minowa, Kazuyuki; Fukuda, Hiroshi; Yamasaki, Michio (Hokkaido Univ., Sapporo (Japan). School of Dentistry)

    1992-04-01

    Salivary gland scintigraphy with {sup 99m}TcO{sub 4}{sup -} is a simple method to evaluate salivary gland function and has been available as a technique using a time/activity curve for a number of years. But, there were few reports on the relationship between the various patterns of the time/activity curves and the salivary flow rate from the gland. This presents correlation between the time/activity curve pattern and the salivary flow rate from the parotid gland. Sixty-five patients complaining of xerostomia were examined. Sixty-two were female and 3 male (average age 45.6 years, range 17-69 years). Their diagnosis were 26 Sjoegren Syndrome, 28 suspicion of Sjoegren Syndrome and 11 parotiditis. The salivary flow rate from parotid gland was measured by stimulation with 10% citric acid using modified Carlson crittenden cup every 10 seconds for 5 min. 185 MBq {sup 99m}TcO{sub 4}{sup -} was injected intravenously and sequential scintigraphy was performed. Time/activity curves were recorded on film. Six kinds of basic patterns were as follows: normal pattern, median pattern, flat pattern and sloped pattern (Mita et al 1981), reaccumulation flat pattern and poor secretion (Stimulant secretory ratio: less than 70%) pattern by us. The amount of saliva was as follows: normal pattern (n=31), 5.4+0.4 ml; reaccumulation flat pattern (n=3), 4.2+0.6 ml; poor secretion pattern (n=18), 4.1+0.5 ml; median pattern (n=20), 3.5+0.5 ml; flat pattern (n=11), 2.6+0.5 ml and sloped pattern (n=1), 1.5 ml. Normal pattern versus poor secretion pattern, median pattern and flat pattern in the salivary flow rate were statistically significant as determined by Students' t-test. We assessed the correlation between the pattern of time/activity curve in the salivary gland scintigraphy and the amount of saliva. (author).

  9. Borehole radar directionality in the time domain in small aperture antennas

    CSIR Research Space (South Africa)

    Vogt, DR

    2008-06-01

    Full Text Available by interpolation. Initial tests show that mutual coupling between the antenna elements does affect the relative timing, but does not prevent the extraction of usable directional data. Experimental data from a test tank confirms that estimates of reflector... the phase differ- ences at each antenna. They showed that mutual cou- pling was tolerable. In a related paper [9] they presented an algorithm to recover direction that performed well. II. SYSTEM DESCRIPTION In this paper, a directional antenna...

  10. Determination of the response time of pressure transducers using the direct method

    International Nuclear Information System (INIS)

    Perillo, S.R.P.

    1994-01-01

    The available methods to determine the response time of nuclear safety related pressure transducers are discussed, with emphasis to the direct method. In order to perform the experiments, a Hydraulic Ramp Generator was built. The equipment produces ramp pressure transients simultaneously to a reference transducer and to the transducer under test. The time lag between the output of the two transducers, when they reach a predetermined setpoint, is measured as the time delay of the transducer under test. Some results using the direct method to determine the time delay of pressure transducers (1 E Class Conventional) are presented. (author). 18 refs, 35 figs, 12 tabs

  11. Quantification of Endogenous Cholesterol in Human Serum on Paper Using Direct Analysis in Real Time Mass Spectrometry.

    Science.gov (United States)

    Hsieh, Hua-Yi; Li, Li-Hua; Hsu, Ren-Yu; Kao, Wei-Fong; Huang, Ying-Chen; Hsu, Cheng-Chih

    2017-06-06

    Blood testing for endogenous small metabolites to determine physiological and biochemical states is routine for laboratory analysis. Here we demonstrate that by combining the commercial direct analysis in real time (DART) ion source with an ion trap mass spectrometer, native cholesterol in its free alcohol form is readily detected from a few hundred nanoliters of human serum loaded onto chromatography paper. Deuterium-labeled cholesterol was used as the internal standard to obtain the absolute quantity of the endogenous cholesterol. The amount of the cholesterol measured by this paper-loaded DART mass spectrometry (pDART-MS) is statistically comparable with that obtained by using commercially available fluorometric-enzymatic assay and liquid chromatography/mass spectrometry. Furthermore, sera from 21 participants at three different time points in an ultramarathon were collected to obtain their cholesterol levels. The test requires only very minimal sample preparation, and the concentrations of cholesterol in each sample were acquired within a minute.

  12. Hopf bifurcation analysis of Chen circuit with direct time delay feedback

    International Nuclear Information System (INIS)

    Hai-Peng, Ren; Wen-Chao, Li; Ding, Liu

    2010-01-01

    Direct time delay feedback can make non-chaotic Chen circuit chaotic. The chaotic Chen circuit with direct time delay feedback possesses rich and complex dynamical behaviours. To reach a deep and clear understanding of the dynamics of such circuits described by delay differential equations, Hopf bifurcation in the circuit is analysed using the Hopf bifurcation theory and the central manifold theorem in this paper. Bifurcation points and bifurcation directions are derived in detail, which prove to be consistent with the previous bifurcation diagram. Numerical simulations and experimental results are given to verify the theoretical analysis. Hopf bifurcation analysis can explain and predict the periodical orbit (oscillation) in Chen circuit with direct time delay feedback. Bifurcation boundaries are derived using the Hopf bifurcation analysis, which will be helpful for determining the parameters in the stabilisation of the originally chaotic circuit

  13. You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists.

    Science.gov (United States)

    Baladi, Michelle G; Daws, Lynette C; France, Charles P

    2012-07-01

    The important role of dopamine (DA) in mediating feeding behavior and the positive reinforcing effects of some drugs is well recognized. Less widely studied is how feeding conditions might impact the sensitivity of drugs acting on DA systems. Food restriction, for example, has often been the focus of aging and longevity studies; however, other studies have demonstrated that mild food restriction markedly increases sensitivity to direct- and indirect-acting DA receptor agonists. Moreover, it is becoming clear that not only the amount of food, but the type of food, is an important factor in modifying the effects of drugs. Given the increased consumption of high fat and sugary foods, studies are exploring how consumption of highly palatable food impacts DA neurochemistry and the effects of drugs acting on these systems. For example, eating high fat chow increases sensitivity to some behavioral effects of direct- as well as indirect-acting DA receptor agonists. A compelling mechanistic possibility is that central DA pathways that mediate the effects of some drugs are regulated by one or more of the endocrine hormones (e.g. insulin) that undergo marked changes during food restriction or after consuming high fat or sugary foods. Although traditionally recognized as an important signaling molecule in regulating energy homeostasis, insulin can also regulate DA neurochemistry. Because direct- and indirect-acting DA receptor drugs are used therapeutically and some are abused, a better understanding of how food intake impacts response to these drugs would likely facilitate improved treatment of clinical disorders and provide information that would be relevant to the causes of vulnerability to abuse drugs. This article is part of a Special Issue entitled 'Central Control of Food Intake'. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. European social citizenship and gender: the part-time work directive

    NARCIS (Netherlands)

    Bleijenbergh, I.L.; de Bruijn, J.G.M.; Bussemaker, M.

    2004-01-01

    This article considers whether the development of European rights for workers implies a European social citizenship. It analyses the debate during the preparation and adoption of the EU Directive on part-time work in 1997, which guarantees part-time workers (who are primarily women) the same pay and

  15. A rapid and direct real time PCR-based method for identification of Salmonella spp

    DEFF Research Database (Denmark)

    Rodriguez-Lazaro, D.; Hernández, Marta; Esteve, T.

    2003-01-01

    The aim of this work was the validation of a rapid, real-time PCR assay based on TaqMan((R)) technology for the unequivocal identification of Salmonella spp. to be used directly on an agar-grown colony. A real-time PCR system targeting at the Salmonella spp. invA gene was optimized and validated ...

  16. Confirming therapeutic target of protopine using immobilized β2 -adrenoceptor coupled with site-directed molecular docking and the target-drug interaction by frontal analysis and injection amount-dependent method.

    Science.gov (United States)

    Liu, Guangxin; Wang, Pei; Li, Chan; Wang, Jing; Sun, Zhenyu; Zhao, Xinfeng; Zheng, Xiaohui

    2017-07-01

    Drug-protein interaction analysis is pregnant in designing new leads during drug discovery. We prepared the stationary phase containing immobilized β 2 -adrenoceptor (β 2 -AR) by linkage of the receptor on macroporous silica gel surface through N,N'-carbonyldiimidazole method. The stationary phase was applied in identifying antiasthmatic target of protopine guided by the prediction of site-directed molecular docking. Subsequent application of immobilized β 2 -AR in exploring the binding of protopine to the receptor was realized by frontal analysis and injection amount-dependent method. The association constants of protopine to β 2 -AR by the 2 methods were (1.00 ± 0.06) × 10 5 M -1 and (1.52 ± 0.14) × 10 4 M -1 . The numbers of binding sites were (1.23 ± 0.07) × 10 -7 M and (9.09 ± 0.06) × 10 -7 M, respectively. These results indicated that β 2 -AR is the specific target for therapeutic action of protopine in vivo. The target-drug binding occurred on Ser 169 in crystal structure of the receptor. Compared with frontal analysis, injection amount-dependent method is advantageous to drug saving, improvement of sampling efficiency, and performing speed. It has grave potential in high-throughput drug-receptor interaction analysis. Copyright © 2017 John Wiley & Sons, Ltd.

  17. What aspects of rehabilitation provision contribute to self-reported met needs for rehabilitation one year after stroke--amount, place, operator or timing?

    DEFF Research Database (Denmark)

    Tistad, Malin; von Koch, Lena; Sjöstrand, Christina

    2013-01-01

    BACKGROUND AND OBJECTIVE: To a large extent, people who have suffered a stroke report unmet needs for rehabilitation. The purpose of this study was to explore aspects of rehabilitation provision that potentially contribute to self-reported met needs for rehabilitation 12 months after stroke...... with consideration also to severity of stroke. METHODS: The participants (n = 173) received care at the stroke units at the Karolinska University Hospital, Sweden. Using a questionnaire, the dependent variable, self-reported met needs for rehabilitation, was collected at 12 months after stroke. The independent...... therapist, speech therapist) and time after stroke onset. Multivariate logistic regression analyses regarding the aspects of rehabilitation were performed for the participants who were divided into three groups based on stroke severity at onset. RESULTS: Participants with moderate/severe stroke who had seen...

  18. Direct Measurements of Smartphone Screen-Time: Relationships with Demographics and Sleep

    OpenAIRE

    Christensen, Matthew A.; Bettencourt, Laura; Kaye, Leanne; Moturu, Sai T.; Nguyen, Kaylin T.; Olgin, Jeffrey E.; Pletcher, Mark J.; Marcus, Gregory M.

    2016-01-01

    Background Smartphones are increasingly integrated into everyday life, but frequency of use has not yet been objectively measured and compared to demographics, health information, and in particular, sleep quality. Aims The aim of this study was to characterize smartphone use by measuring screen-time directly, determine factors that are associated with increased screen-time, and to test the hypothesis that increased screen-time is associated with poor sleep. Methods We performed a cross-sectio...

  19. Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis.

    Science.gov (United States)

    Voelkl, Bernhard; Portugal, Steven J; Unsöld, Markus; Usherwood, James R; Wilson, Alan M; Fritz, Johannes

    2015-02-17

    One conspicuous feature of several larger bird species is their annual migration in V-shaped or echelon formation. When birds are flying in these formations, energy savings can be achieved by using the aerodynamic up-wash produced by the preceding bird. As the leading bird in a formation cannot profit from this up-wash, a social dilemma arises around the question of who is going to fly in front? To investigate how this dilemma is solved, we studied the flight behavior of a flock of juvenile Northern bald ibis (Geronticus eremita) during a human-guided autumn migration. We could show that the amount of time a bird is leading a formation is strongly correlated with the time it can itself profit from flying in the wake of another bird. On the dyadic level, birds match the time they spend in the wake of each other by frequent pairwise switches of the leading position. Taken together, these results suggest that bald ibis cooperate by directly taking turns in leading a formation. On the proximate level, we propose that it is mainly the high number of iterations and the immediacy of reciprocation opportunities that favor direct reciprocation. Finally, we found evidence that the animals' propensity to reciprocate in leading has a substantial influence on the size and cohesion of the flight formations.

  20. Less-structured time in children's daily lives predicts self-directed executive functioning.

    Science.gov (United States)

    Barker, Jane E; Semenov, Andrei D; Michaelson, Laura; Provan, Lindsay S; Snyder, Hannah R; Munakata, Yuko

    2014-01-01

    Executive functions (EFs) in childhood predict important life outcomes. Thus, there is great interest in attempts to improve EFs early in life. Many interventions are led by trained adults, including structured training activities in the lab, and less-structured activities implemented in schools. Such programs have yielded gains in children's externally-driven executive functioning, where they are instructed on what goal-directed actions to carry out and when. However, it is less clear how children's experiences relate to their development of self-directed executive functioning, where they must determine on their own what goal-directed actions to carry out and when. We hypothesized that time spent in less-structured activities would give children opportunities to practice self-directed executive functioning, and lead to benefits. To investigate this possibility, we collected information from parents about their 6-7 year-old children's daily, annual, and typical schedules. We categorized children's activities as "structured" or "less-structured" based on categorization schemes from prior studies on child leisure time use. We assessed children's self-directed executive functioning using a well-established verbal fluency task, in which children generate members of a category and can decide on their own when to switch from one subcategory to another. The more time that children spent in less-structured activities, the better their self-directed executive functioning. The opposite was true of structured activities, which predicted poorer self-directed executive functioning. These relationships were robust (holding across increasingly strict classifications of structured and less-structured time) and specific (time use did not predict externally-driven executive functioning). We discuss implications, caveats, and ways in which potential interpretations can be distinguished in future work, to advance an understanding of this fundamental aspect of growing up.

  1. The relationship between health locus of control, depression, and sociodemographic factors and amount of time breast cancer patients wait before seeking diagnosis and treatment.

    Science.gov (United States)

    Marijanović, Inga; Pavleković, Gordana; Buhovac, Teo; Martinac, Marko

    2017-09-01

    In the Federation of Bosnia and Herzegovina, the prevalence and incidence of breast cancer has been increasing, and the national programme of early prevention, administered locally, is sporadic and without quality assurance. While many factors may influence women's decision to adopt prevention-oriented behaviours regarding breast cancer, this study has emphasised the importance of sociodemographic factors, psychological factors and mental wellbeing. Participants in the study were all patients who, during one year, were admitted for the first time for diagnosis and treatment in the biggest Clinical hospitals of the Herzegovina-Neretva region Patients were divided into two groups based on their TNM classification: "early stage" and "late stage". Three instruments were used in this study: an individual questionnaire about demographic and socioeconomic characteristics of the woman, the Multidimensional Health Locus of Control scales, and the Hamilton Depression Rating Scale. The majority of patients diagnosed with advanced disease were admitted to hospital in the late/advanced stages of the disease. Multi-variant analysis showed that the most statistically significant positive predictor for early admittance in hospital is living with family and marital status while religiosity has a negative predictive value. The results indicate that 59.7% of respondents do not have depression, while the remainder do have some degree of depression. There was no statistically significant difference in the degree of depression between women who were diagnosed and treated early and those who were not. The employment status of the respondents was the only significant factor related to degree of depression. Although health locus of control and depression are not statistically significant predictors of early hospital treatment, the recommendation is that further studies focus on the implementation of MHLC and HDRS scales within the community. This could be useful in planning appropriate and

  2. Offset-Free Direct Power Control of DFIG Under Continuous-Time Model Predictive Control

    DEFF Research Database (Denmark)

    Errouissi, Rachid; Al-Durra, Ahmed; Muyeen, S.M.

    2017-01-01

    This paper presents a robust continuous-time model predictive direct power control for doubly fed induction generator (DFIG). The proposed approach uses Taylor series expansion to predict the stator current in the synchronous reference frame over a finite time horizon. The predicted stator current...... is directly used to compute the required rotor voltage in order to minimize the difference between the actual stator currents and their references over the predictive time. However, as the proposed strategy is sensitive to parameter variations and external disturbances, a disturbance observer is embedded...... into the control loop to remove the steady-state error of the stator current. It turns out that the steady-state and the transient performances can be identified by simple design parameters. In this paper, the reference of the stator current is directly calculated from the desired stator active and reactive powers...

  3. Dimension reduction of frequency-based direct Granger causality measures on short time series.

    Science.gov (United States)

    Siggiridou, Elsa; Kimiskidis, Vasilios K; Kugiumtzis, Dimitris

    2017-09-01

    The mainstream in the estimation of effective brain connectivity relies on Granger causality measures in the frequency domain. If the measure is meant to capture direct causal effects accounting for the presence of other observed variables, as in multi-channel electroencephalograms (EEG), typically the fit of a vector autoregressive (VAR) model on the multivariate time series is required. For short time series of many variables, the estimation of VAR may not be stable requiring dimension reduction resulting in restricted or sparse VAR models. The restricted VAR obtained by the modified backward-in-time selection method (mBTS) is adapted to the generalized partial directed coherence (GPDC), termed restricted GPDC (RGPDC). Dimension reduction on other frequency based measures, such the direct directed transfer function (dDTF), is straightforward. First, a simulation study using linear stochastic multivariate systems is conducted and RGPDC is favorably compared to GPDC on short time series in terms of sensitivity and specificity. Then the two measures are tested for their ability to detect changes in brain connectivity during an epileptiform discharge (ED) from multi-channel scalp EEG. It is shown that RGPDC identifies better than GPDC the connectivity structure of the simulated systems, as well as changes in the brain connectivity, and is less dependent on the free parameter of VAR order. The proposed dimension reduction in frequency measures based on VAR constitutes an appropriate strategy to estimate reliably brain networks within short-time windows. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. 42 CFR 493.649 - Methodology for determining fee amount.

    Science.gov (United States)

    2010-10-01

    ... fringe benefit costs to support the required number of State inspectors, management and direct support... full time equivalent employee. Included in this cost are salary and fringe benefit costs, necessary... 42 Public Health 5 2010-10-01 2010-10-01 false Methodology for determining fee amount. 493.649...

  5. Performing T-tests to Compare Autocorrelated Time Series Data Collected from Direct-Reading Instruments.

    Science.gov (United States)

    O'Shaughnessy, Patrick; Cavanaugh, Joseph E

    2015-01-01

    Industrial hygienists now commonly use direct-reading instruments to evaluate hazards in the workplace. The stored values over time from these instruments constitute a time series of measurements that are often autocorrelated. Given the need to statistically compare two occupational scenarios using values from a direct-reading instrument, a t-test must consider measurement autocorrelation or the resulting test will have a largely inflated type-1 error probability (false rejection of the null hypothesis). A method is described for both the one-sample and two-sample cases which properly adjusts for autocorrelation. This method involves the computation of an "equivalent sample size" that effectively decreases the actual sample size when determining the standard error of the mean for the time series. An example is provided for the one-sample case, and an example is given where a two-sample t-test is conducted for two autocorrelated time series comprised of lognormally distributed measurements.

  6. Strong normalization by type-directed partial evaluation and run-time code generation

    DEFF Research Database (Denmark)

    Balat, Vincent; Danvy, Olivier

    1998-01-01

    We investigate the synergy between type-directed partial evaluation and run-time code generation for the Caml dialect of ML. Type-directed partial evaluation maps simply typed, closed Caml values to a representation of their long βη-normal form. Caml uses a virtual machine and has the capability...... to load byte code at run time. Representing the long βη-normal forms as byte code gives us the ability to strongly normalize higher-order values (i.e., weak head normal forms in ML), to compile the resulting strong normal forms into byte code, and to load this byte code all in one go, at run time. We...... conclude this note with a preview of our current work on scaling up strong normalization by run-time code generation to the Caml module language....

  7. Strong Normalization by Type-Directed Partial Evaluation and Run-Time Code Generation

    DEFF Research Database (Denmark)

    Balat, Vincent; Danvy, Olivier

    1997-01-01

    We investigate the synergy between type-directed partial evaluation and run-time code generation for the Caml dialect of ML. Type-directed partial evaluation maps simply typed, closed Caml values to a representation of their long βη-normal form. Caml uses a virtual machine and has the capability...... to load byte code at run time. Representing the long βη-normal forms as byte code gives us the ability to strongly normalize higher-order values (i.e., weak head normal forms in ML), to compile the resulting strong normal forms into byte code, and to load this byte code all in one go, at run time. We...... conclude this note with a preview of our current work on scaling up strong normalization by run-time code generation to the Caml module language....

  8. Continuous-Time Classical and Quantum Random Walk on Direct Product of Cayley Graphs

    International Nuclear Information System (INIS)

    Salimi, S.; Jafarizadeh, M. A.

    2009-01-01

    In this paper we define direct product of graphs and give a recipe for obtaining probability of observing particle on vertices in the continuous-time classical and quantum random walk. In the recipe, the probability of observing particle on direct product of graph is obtained by multiplication of probability on the corresponding to sub-graphs, where this method is useful to determining probability of walk on complicated graphs. Using this method, we calculate the probability of continuous-time classical and quantum random walks on many of finite direct product Cayley graphs (complete cycle, complete K n , charter and n-cube). Also, we inquire that the classical state the stationary uniform distribution is reached as t → ∞ but for quantum state is not always satisfied. (general)

  9. Direct determination of scattering time delays using the R-matrix propagation method

    International Nuclear Information System (INIS)

    Walker, R.B.; Hayes, E.F.

    1989-01-01

    A direct method for determining time delays for scattering processes is developed using the R-matrix propagation method. The procedure involves the simultaneous generation of the global R matrix and its energy derivative. The necessary expressions to obtain the energy derivative of the S matrix are relatively simple and involve many of the same matrix elements required for the R-matrix propagation method. This method is applied to a simple model for a chemical reaction that displays sharp resonance features. The test results of the direct method are shown to be in excellent agreement with the traditional numerical differentiation method for scattering energies near the resonance energy. However, for sharp resonances the numerical differentiation method requires calculation of the S-matrix elements at many closely spaced energies. Since the direct method presented here involves calculations at only a single energy, one is able to generate accurate energy derivatives and time delays much more efficiently and reliably

  10. Generate tri-directional spectra-compatible time histories using HHT method

    International Nuclear Information System (INIS)

    Li, Bo; Xie, Wei-Chau; Pandey, Mahesh D.

    2016-01-01

    Highlights: • Hilbert–Huang Transform are applied to modify real earthquake records. • Generate tri-directional time histories compatible with target spectra. • Both GRS and FRS are considered as target spectra. • Target spectra with multiple damping ratios are considered. - Abstract: This paper proposes two algorithms to generate spectrum-compatible time histories based on two approaches recommended by USNRC Standard Review Plan 3.7.1. Hilbert–Huang Transform technique is used to analyze frequency contents and amplitudes of seed motions. Through adjusting the frequency contents and amplitudes of seed motions, spectrum-compatible time histories are obtained. The first algorithm is to generate tri-directional time histories compatible with multi-damping target design spectra (ground response spectra or floor response spectra). The second algorithm is to generate tri-directional time histories compatible with single-damping target design spectra. Examples are presented to demonstrate versatility of these two proposed algorithms to generate spectra-compatible time histories.

  11. Generate tri-directional spectra-compatible time histories using HHT method

    Energy Technology Data Exchange (ETDEWEB)

    Li, Bo; Xie, Wei-Chau, E-mail: xie@uwaterloo.ca; Pandey, Mahesh D.

    2016-11-15

    Highlights: • Hilbert–Huang Transform are applied to modify real earthquake records. • Generate tri-directional time histories compatible with target spectra. • Both GRS and FRS are considered as target spectra. • Target spectra with multiple damping ratios are considered. - Abstract: This paper proposes two algorithms to generate spectrum-compatible time histories based on two approaches recommended by USNRC Standard Review Plan 3.7.1. Hilbert–Huang Transform technique is used to analyze frequency contents and amplitudes of seed motions. Through adjusting the frequency contents and amplitudes of seed motions, spectrum-compatible time histories are obtained. The first algorithm is to generate tri-directional time histories compatible with multi-damping target design spectra (ground response spectra or floor response spectra). The second algorithm is to generate tri-directional time histories compatible with single-damping target design spectra. Examples are presented to demonstrate versatility of these two proposed algorithms to generate spectra-compatible time histories.

  12. Quantum and classical strong direct product theorems and optimal time-space tradeoffs

    NARCIS (Netherlands)

    H. Klauck (Hartmut); R. Spalek (Robert); R. M. de Wolf (Ronald)

    2007-01-01

    textabstractA strong direct product theorem says that if we want to compute $k$ independent instances of a function, using less than $k$ times the resources needed for one instance, then our overall success probability will be exponentially small in $k$. We establish such theorems for the

  13. Sports Direct to appoint full-time nurse after inquiry into employment practices.

    Science.gov (United States)

    2016-09-14

    Retailer Sports Direct is to appoint a full-time nurse at its vast warehouse in response to concerns about health and safety. The firm was the subject of a House of Commons business, innovation and skills select committee inquiry into its employment practices.

  14. Direct Adaptive Control of a Class of Nonlinear Discrete-Time Systems

    DEFF Research Database (Denmark)

    Bendtsen, Jan Dimon

    2004-01-01

    In this paper we deal with direct adaptive control of a specific class of discrete-time SISO systems, where the nonlinearities are convex and an upper bound is known. We use a control law based on a linear combination of a set of globally uniformly bounded basis functions with compact support, wh...

  15. [Meeting the needs of the European working time directive in german medical profession].

    Science.gov (United States)

    Friedrich, M; Popov, A F; Schmitto, J D; Bireta, C; Emmert, A; Tirilomis, T

    2011-06-01

    The legal obligation of the European Working Time Directive with its implementation into a German Working Hours Act requires German hospitals to give up old structures and requires the implementation of new working time models. The failure of the revision of the European Working Time Directive in April 2009 prevented that any changes of status quo might happen in the near future. Fundamental terms of the working law for the medical area have been elucidated and have been implemented into concrete calculation formulas. The planned working time has been clearly determined. Particularly, on-call duties and a signed "OptOut-declaration" have huge effects on the upper limit of the working time that is to be determined. Shift duty leads to the greatest limitations of the upper limit of the working time. The Working Hours Act defines the maximal, available, individual working time budget and thus the working time budget of a hospital and it limits the maximal availability of the service providers of a hospital as well as defining the maximal personnel costs. Transparency in this area lays the foundation for an effective time management and the creation of new working time models in accordance with the European Working Time Directive as well as the Working Hours Act and the "TVÄ" (labour contract for doctors at municipal hospitals). It is possible, with the knowledge of the maximal working time budget and the thereof resulting personnel costs, to calculate the economical revenues better. The reallocation of the working time of doctors enables efficiency enhancement. It is necessary to demand a clear definition of the tasks of doctors with the consequential discharge of tasks that should not/do not belong to the responsibilities of a doctor. This would lead to a more attractive working environment for doctors at hospitals and thus to an improvement of the care of the patients. The implementation of the European Time Directive is not to be seen as unrealizable, as has been

  16. Real-time generation of kd-trees for ray tracing using DirectX 11

    OpenAIRE

    Säll, Martin; Cronqvist, Fredrik

    2017-01-01

    Context. Ray tracing has always been a simple but effective way to create a photorealistic scene but at a greater cost when expanding the scene. Recent improvements in GPU and CPU hardware have made ray tracing faster, making more complex scenes possible with the same amount of time needed to process the scene. Despite the improvements in hardware ray tracing is still rarely run at a interactive speed. Objectives. The aim of this experiment was to implement a new kdtree generation algorithm us...

  17. Direct Observation of Heavy-Tailed Storage Times of Bed Load Tracer Particles Causing Anomalous Superdiffusion

    Science.gov (United States)

    Bradley, D. Nathan

    2017-12-01

    A consensus has formed that the step length distribution of fluvial bed load is thin tailed and that the observed anomalous superdiffusion of bed load tracer particles must arise from heavy-tailed resting times. However, heavy-tailed resting times have never been directly observed in the field over multiple floods. Using 9 years of data from a large bed load tracer experiment, I show that the spatial variance of the tracer plume scales faster than linearly with integrated excess stream power, indicating anomalous superdiffusion. The superdiffusion is caused by a heavy-tailed distribution of observed storage times that is fit with a truncated Pareto distribution with a tail parameter that is predicted by anomalous diffusion theory. The heavy-tailed distribution of storage times causes the tracer virtual velocity to slow over time, indicated by a sublinear increase in the mean displacement that is predicted by the storage time distribution tail parameter.

  18. Participant observation of time allocation, direct patient contact and simultaneous activities in hospital physicians

    Directory of Open Access Journals (Sweden)

    Zupanc Andrea

    2009-06-01

    Full Text Available Abstract Background Hospital physicians' time is a critical resource in medical care. Two aspects are of interest. First, the time spent in direct patient contact – a key principle of effective medical care. Second, simultaneous task performance ('multitasking' which may contribute to medical error, impaired safety behaviour, and stress. There is a call for instruments to assess these aspects. A preliminary study to gain insight into activity patterns, time allocation and simultaneous activities of hospital physicians was carried out. Therefore an observation instrument for time-motion-studies in hospital settings was developed and tested. Methods 35 participant observations of internists and surgeons of a German municipal 300-bed hospital were conducted. Complete day shifts of hospital physicians on wards, emergency ward, intensive care unit, and operating room were continuously observed. Assessed variables of interest were time allocation, share of direct patient contact, and simultaneous activities. Inter-rater agreement of Kappa = .71 points to good reliability of the instrument. Results Hospital physicians spent 25.5% of their time at work in direct contact with patients. Most time was allocated to documentation and conversation with colleagues and nursing staff. Physicians performed parallel simultaneous activities for 17–20% of their work time. Communication with patients, documentation, and conversation with colleagues and nursing staff were the most frequently observed simultaneous activities. Applying logit-linear analyses, specific primary activities increase the probability of particular simultaneous activities. Conclusion Patient-related working time in hospitals is limited. The potential detrimental effects of frequently observed simultaneous activities on performance outcomes need further consideration.

  19. Fabrication of MEA based on optimum amount of Co in PdxCo/C alloy nanoparticles as a new cathode for oxygen reduction reaction in passive direct methanol fuel cells

    International Nuclear Information System (INIS)

    Gharibi, Hussein; Golmohammadi, Farhad; Kheirmand, Mehdi

    2013-01-01

    Highlights: ► The optimal amount of Pd/Co in the catalyst layer reduces the polarization resistance in comparison with Pd alone. ► The Pd/Co in catalyst layer increases the Pd utilization in the ORR. ► The DMFC test results indicate that the MEA prepared from Pd 3 Co/C cathode exhibits best performance. -- Abstract: Carbon supported Pd and Pd x Co alloy electrocatalysts of different Pd x Co atomic ratios (x = 1, 2, 3 and 10) were prepared by the impregnation synthesis method at room temperature without heat treatment by ethylene glycol (EG) reduction. As prepared Pd x Co bimetallic nanoparticles show a single-phase face-centered-cubic (fcc) disordered structure. The performance of these electrodes in the ORR was measured with cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), inductive coupled plasma (ICP), X-ray diffraction (XRD); scanning electron microscopy coupled to energy dispersive X-ray (SEM–EDX) and transmission electron microscope (TEM). For synthesized Pd x Co/C electrocatalysts, the highest catalytic activity for the ORR, was found for a Pd:Co atomic ratio of 3:1 in acid media at the presence and absence of methanol with optimal Pd–Pd bond distance (0.2729 nm). Since the Pd x Co/C alloy electrocatalysts are inactive for the adsorption and oxidation of methanol, it can act as a methanol-tolerant ORR catalyst in a direct methanol fuel cell (DMFC). A membrane-electrode assembly (MEA) has been prepared by employing of the Pd 3 Co/C as a cathode for passive direct methanol fuel cell and characterized by polarization curves and impedance diagrams. The DMFC test results indicate that the MEA prepared from Pd 3 Co/C cathode exhibits better performance compared to the MEA prepared from Pt/C (Electrochem) and an in-house Pd/C catalyst synthesized, in terms of maximum power density and minimum charge transfer resistance

  20. Characterizing system dynamics with a weighted and directed network constructed from time series data

    International Nuclear Information System (INIS)

    Sun, Xiaoran; Small, Michael; Zhao, Yi; Xue, Xiaoping

    2014-01-01

    In this work, we propose a novel method to transform a time series into a weighted and directed network. For a given time series, we first generate a set of segments via a sliding window, and then use a doubly symbolic scheme to characterize every windowed segment by combining absolute amplitude information with an ordinal pattern characterization. Based on this construction, a network can be directly constructed from the given time series: segments corresponding to different symbol-pairs are mapped to network nodes and the temporal succession between nodes is represented by directed links. With this conversion, dynamics underlying the time series has been encoded into the network structure. We illustrate the potential of our networks with a well-studied dynamical model as a benchmark example. Results show that network measures for characterizing global properties can detect the dynamical transitions in the underlying system. Moreover, we employ a random walk algorithm to sample loops in our networks, and find that time series with different dynamics exhibits distinct cycle structure. That is, the relative prevalence of loops with different lengths can be used to identify the underlying dynamics

  1. Characterizing system dynamics with a weighted and directed network constructed from time series data

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Xiaoran, E-mail: sxr0806@gmail.com [Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen 518055 (China); School of Mathematics and Statistics, The University of Western Australia, Crawley WA 6009 (Australia); Small, Michael, E-mail: michael.small@uwa.edu.au [School of Mathematics and Statistics, The University of Western Australia, Crawley WA 6009 (Australia); Zhao, Yi [Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen 518055 (China); Xue, Xiaoping [Department of Mathematics, Harbin Institute of Technology, Harbin 150025 (China)

    2014-06-15

    In this work, we propose a novel method to transform a time series into a weighted and directed network. For a given time series, we first generate a set of segments via a sliding window, and then use a doubly symbolic scheme to characterize every windowed segment by combining absolute amplitude information with an ordinal pattern characterization. Based on this construction, a network can be directly constructed from the given time series: segments corresponding to different symbol-pairs are mapped to network nodes and the temporal succession between nodes is represented by directed links. With this conversion, dynamics underlying the time series has been encoded into the network structure. We illustrate the potential of our networks with a well-studied dynamical model as a benchmark example. Results show that network measures for characterizing global properties can detect the dynamical transitions in the underlying system. Moreover, we employ a random walk algorithm to sample loops in our networks, and find that time series with different dynamics exhibits distinct cycle structure. That is, the relative prevalence of loops with different lengths can be used to identify the underlying dynamics.

  2. Foreign Remittances, Foreign Direct Investment, Foreign Imports and Economic Growth in Pakistan: A Time Series Analysis

    Directory of Open Access Journals (Sweden)

    Muhammad Tahir

    2015-10-01

    Full Text Available This empirical research paper focuses on establishing a relationship between external determinants and economic growth of Pakistan economy. Empirical analyses are carried out with time series econometric techniques using data over the period of 1977-2013. The main finding is that external determinants such as foreign remittances, foreign direct investment, and foreign imports matter from a growth perspective. Foreign remittances and foreign direct investment have a significant positive role in the growth process of Pakistan economy. Furthermore, it is found that foreign imports have adversely influenced the economic growth of Pakistan. The study recommends that policy makers shall take appropriate steps to increase the inflow of both foreign remittances and foreign direct investment in order to achieve the long run economic growth.

  3. Effects of pilot injection timing and EGR on a modern V6 common rail direct injection diesel engine

    Science.gov (United States)

    Rosli Abdullah, Nik; Mamat, Rizalman; Wyszynski, Miroslaw L.; Tsolakis, Anthanasios; Xu, Hongming

    2013-12-01

    Nitric oxide and smoke emissions in diesel engine can be controlled by optimising the air/fuel mixture. Early injection produces premixed charge resulted in simultaneous NOx and smoke emissions reduction. However, there could be an increase in hydrocarbons and CO emissions due to fuel impinged to the cylinder wall. The focus of the present work is to investigate the effects of a variation of pilot injection timing with EGR to NOx and smoke level on a modern V6 common rail direct injection. This study is carried out at two different engine load conditions of 30 Nm and 55 Nm, at constant engine speed of 2000 rpm. The results show that the early pilot injection timing contributed to the lower smoke level and higher NOx emissions. The higher level of NOx is due to higher combustion temperatures resulting from the complete combustion. Meanwhile, the lower smoke level is due to complete fuel combustion and soot oxidation. The early pilot injection timing produces an intermediate main ignition delay which also contributed to complete combustion. The formation of smoke is higher at a high engine load compared with low engine load due to the higher amount of fuel being injected.

  4. Time-resolved studies of direct effects of radiation on DNA

    International Nuclear Information System (INIS)

    Fielden, E.M.; O'Neill, P.; Al-Kazwini, A.

    1987-01-01

    The biological changes induced by ionising radiation are a consequence of radiation-induced chemical events taking place at times <1s. These events are strongly influenced by the presence of chemical modifiers. Since DNA is a principle target for radiation-induced cell killing, DNA-free radicals are generated by direct ionisation of DNA moieties (direct effect) and by reaction with hydroxyl radicals formed by radiolysis of the water which is in the vicinity of the DNA (indirect effect). In order to study the 'direct' effects of radiation on DNA the following model approaches are discussed:- 1) Use of the technique of pulse radiolysis to investigate in aqueous solution the interactions of deoxynucleosides with SO/sub 4//sup .-/ whereby one-electron oxidised species of the bases are generated; and 2) time resolved, radiation-induced changes to solid DNA and related macromolecules (e.g. radiation-induced luminescence) in order to obtain an understanding of charge/energy migration as a result of ionisation of DNA. The influence of chemical modifiers and of environment is discussed in terms of the properties of the radiation-induced species produced. Since the properties of base radicals produced by SO/sub 4//sup .-/ are similar to those of the base OH-adducts oxidising properties, potential similarities between the 'direct' and 'indirect' effects of radiation are presented

  5. Influence of Short-time Oxidation on Corrosion Properties of Directionally Solidified Superalloys with Different Orientations

    Directory of Open Access Journals (Sweden)

    MA Luo-ning

    2016-07-01

    Full Text Available In order to investigate the corrosion performance on intersecting and longitudinal surfaces of unoxidized and oxidized directionally solidified superalloys, Ni-base directionally solidified superalloy DZ125 and Co-base directionally solidified superalloy DZ40M were selected. Oxidation behavior on both alloys with different orientations was investigated at 1050℃ at different times, simulating the oxidation process of vanes or blades in service; subsequent electrochemical performance in 3.5%NaCl aqueous solution was studied on two orientations of unoxidized and oxidized alloys, simulating the corrosion process of superalloy during downtime. The results show that grain boundaries and sub-boundaries of directionally solidified superalloys are susceptible to corrosion and thus longitudinal surface with lower area fraction of grain boundaries has higher corrosion resistance. Compared to intersecting surface of alloys, the structure of grain boundaries of longitudinal surface is less conducive to diffusion and thus the oxidation rate on longitudinal surface is lower. Formation of oxide layers on alloys after short-time oxidation provides protective effect and enhances the corrosion resistance.

  6. Future mission studies: Forecasting solar flux directly from its chaotic time series

    Science.gov (United States)

    Ashrafi, S.

    1991-01-01

    The mathematical structure of the programs written to construct a nonlinear predictive model to forecast solar flux directly from its time series without reference to any underlying solar physics is presented. This method and the programs are written so that one could apply the same technique to forecast other chaotic time series, such as geomagnetic data, attitude and orbit data, and even financial indexes and stock market data. Perhaps the most important application of this technique to flight dynamics is to model Goddard Trajectory Determination System (GTDS) output of residues between observed position of spacecraft and calculated position with no drag (drag flag = off). This would result in a new model of drag working directly from observed data.

  7. Direct modulation of aberrant brain network connectivity through real-time NeuroFeedback.

    Science.gov (United States)

    Ramot, Michal; Kimmich, Sara; Gonzalez-Castillo, Javier; Roopchansingh, Vinai; Popal, Haroon; White, Emily; Gotts, Stephen J; Martin, Alex

    2017-09-16

    The existence of abnormal connectivity patterns between resting state networks in neuropsychiatric disorders, including Autism Spectrum Disorder (ASD), has been well established. Traditional treatment methods in ASD are limited, and do not address the aberrant network structure. Using real-time fMRI neurofeedback, we directly trained three brain nodes in participants with ASD, in which the aberrant connectivity has been shown to correlate with symptom severity. Desired network connectivity patterns were reinforced in real-time, without participants' awareness of the training taking place. This training regimen produced large, significant long-term changes in correlations at the network level, and whole brain analysis revealed that the greatest changes were focused on the areas being trained. These changes were not found in the control group. Moreover, changes in ASD resting state connectivity following the training were correlated to changes in behavior, suggesting that neurofeedback can be used to directly alter complex, clinically relevant network connectivity patterns.

  8. Direct modulation of aberrant brain network connectivity through real-time NeuroFeedback

    Science.gov (United States)

    Kimmich, Sara; Gonzalez-Castillo, Javier; Roopchansingh, Vinai; Popal, Haroon; White, Emily; Gotts, Stephen J; Martin, Alex

    2017-01-01

    The existence of abnormal connectivity patterns between resting state networks in neuropsychiatric disorders, including Autism Spectrum Disorder (ASD), has been well established. Traditional treatment methods in ASD are limited, and do not address the aberrant network structure. Using real-time fMRI neurofeedback, we directly trained three brain nodes in participants with ASD, in which the aberrant connectivity has been shown to correlate with symptom severity. Desired network connectivity patterns were reinforced in real-time, without participants’ awareness of the training taking place. This training regimen produced large, significant long-term changes in correlations at the network level, and whole brain analysis revealed that the greatest changes were focused on the areas being trained. These changes were not found in the control group. Moreover, changes in ASD resting state connectivity following the training were correlated to changes in behavior, suggesting that neurofeedback can be used to directly alter complex, clinically relevant network connectivity patterns. PMID:28917059

  9. Direct and inverse problems in dispersive time-of-flight photocurrent revisited

    Science.gov (United States)

    Sagues, Francesc; Sokolov, Igor M.

    2017-10-01

    Using the fact that the continuous time random walk (CTRW) scheme is a random process subordinated to a simple random walk under the operational time given by the number of steps taken by the walker up to a given time, we revisit the problem of strongly dispersive transport in disordered media, which first lead Scher and Montroll to introducing the power law waiting time distributions. Using a subordination approach permits to disentangle the complexity of the problem, separating the solution of the boundary value problem (which is solved on the level of normal diffusive transport) from the influence of the waiting times, which allows for the solution of the direct problem in the whole time domain (including short times, out of reach of the initial approach), and simplifying strongly the analysis of the inverse problem. This analysis shows that the current traces do not contain information sufficient for unique restoration of the waiting time probability densities, but define a single-parametric family of functions that can be restored, all leading to the same photocurrent forms. The members of the family have the power-law tails which differ only by a prefactor, but may look astonishingly different at their body. The same applies to the multiple trapping model, mathematically equivalent to a special limiting case of CTRW. Contribution to the Topical Issue "Continuous Time Random Walk Still Trendy: Fifty-year History, Current State and Outlook", edited by Ryszard Kutner and Jaume Masoliver.

  10. Explaining Direct Care Resource Use of Nursing Home Residents: Findings from Time Studies in Four States

    Science.gov (United States)

    Arling, Greg; Kane, Robert L; Mueller, Christine; Lewis, Teresa

    2007-01-01

    Objective To explain variation in direct care resource use (RU) of nursing home residents based on the Resource Utilization Groups III (RUG-III) classification system and other resident- and unit-level explanatory variables. Data Sources/Study Setting Primary data were collected on 5,314 nursing home residents in 156 nursing units in 105 facilities from four states (CO, IN, MN, MS) from 1998 to 2004. Study Design Nurses and other direct care staff recorded resident-specific and other time caring for all residents on sampled nursing units. Care time was linked to resident data from the Minimum Data Set assessment instrument. Major variables were: RUG-III group (34-group), other health and functional conditions, licensed and other professional minutes per day, unlicensed minutes per day, and direct care RU (wage-weighted minutes). Resident- and unit-level relationships were examined through hierarchical linear modeling. Data Collection/Extraction Methods Time study data were recorded with hand-held computers, verified for accuracy by project staff at the data collection sites and then merged into resident and unit-level data sets. Principal Findings Resident care time and RU varied between and within nursing units. RUG-III group was related to RU; variables such as length of stay and unit percentage of high acuity residents also were significantly related. Case-mix indices (CMIs) constructed from study data displayed much less variation across RUG-III groups than CMIs from earlier time studies. Conclusions Results from earlier time studies may not be representative of care patterns of Medicaid and private pay residents. New RUG-III CMIs should be developed to better reflect the relative costs of caring for these residents. PMID:17362220

  11. Nonlinear techniques for forecasting solar activity directly from its time series

    Science.gov (United States)

    Ashrafi, S.; Roszman, L.; Cooley, J.

    1993-01-01

    This paper presents numerical techniques for constructing nonlinear predictive models to forecast solar flux directly from its time series. This approach makes it possible to extract dynamical in variants of our system without reference to any underlying solar physics. We consider the dynamical evolution of solar activity in a reconstructed phase space that captures the attractor (strange), give a procedure for constructing a predictor of future solar activity, and discuss extraction of dynamical invariants such as Lyapunov exponents and attractor dimension.

  12. Chaotification of Quasi-zero Stiffness System Via Direct Time-delay Feedback

    Directory of Open Access Journals (Sweden)

    Shuyong Liu

    2013-03-01

    Full Text Available This paper presents a chaotification method based on direct time-delay feedback control for a quasi-zero-stiffness isolation system. An analytical function of time-delay feedback control is derived based on differential-geometry control theory. Furthermore, the feasibility and effectiveness of this method was verified by numerical simulations. Numerical simulations show that this method holds the favorable aspects including the advantage of using tiny control gain, the capability of chaotifying across a large range of parametric domain and the high feasibility of the control implement.

  13. IOS APPLICATION FOR FINDING HALAL FOOD, MOSQUE, QIBLA DIRECTION AND PRAYER TIME

    Directory of Open Access Journals (Sweden)

    Febria Roosita Dwi

    2015-01-01

    Full Text Available Muslim sometimes has trouble when they travel to a new place for find where the location of the halal food and mosque near their location is. Other things that Muslim will have difficulty when they travel in to a new place are find the Qibla direction, pray time in local time and the mosque location near their location. From that problem MLH (Muslim Little Helper want to help them to solve their problem. The process is carried out as follows: The app get the user location, send the location to the YELP API server and muslimshalat.com API to get the location of halal food, and mosque (using YELP and for find the direction of Qibla and the prayer schedule (by using muslimshalat.com API. After the system get the data, then it will show on the Map (using apple map inside the app and put the data as marker. For the Qibla direction and prayer time, it will show in arrow image and listview. This app will be use Swift for the development language. The test result shows that the YELP API can be use only in USA, and internet play as the main rule in this app, because to create connection to the server to pull the data, the system need internet to pass all the data to server.

  14. Outcome and periprocedural time management in referred versus directly admitted stroke patients treated with thrombectomy.

    Science.gov (United States)

    Weber, Ralph; Reimann, Gernot; Weimar, Christian; Winkler, Angela; Berger, Klaus; Nordmeyer, Hannes; Hadisurya, Jeffrie; Brassel, Friedhelm; Kitzrow, Martin; Krogias, Christos; Weber, Werner; Busch, Elmar W; Eyding, Jens

    2016-03-01

    After thrombectomy has shown to be effective in acute stroke patients with large vessel occlusion, the potential benefit of secondary referral for such an intervention needs to be validated. We aimed to compare consecutive stoke patients directly admitted and treated with thrombectomy at a neurointerventional centre with patients secondarily referred for such a procedure from hospitals with a stroke unit. Periprocedure times and mortality in 300 patients primarily treated in eight neurointerventional centres were compared with 343 patients referred from nine other hospitals in a prospective multicentre study of a German neurovascular network. Data on functional outcome at 3 months was available in 430 (76.4%) patients. In-hospital mortality (14.8% versus 11.7%, p = 0.26) and 3 months mortality (21.9% versus 24.1%, p = 0.53) were not statistically different in both patient groups despite a significant shorter symptom to groin puncture time in directly admitted patients, which was mainly caused by a longer interfacility transfer time. We found a nonsignificant trend for better functional outcome at 3 months in directly admitted patients (modified Rankin Scale 0-2, 44.0% versus 35.7%, p = 0.08). Our results show that a drip-and-ship thrombectomy concept can be effectively organized in a metropolitan stroke network. Every effort should be made to speed up the emergency interfacility transfer to a neurointerventional centre in stroke patients eligible for thrombectomy after initial brain imaging.

  15. Rapid, Time-Division Multiplexed, Direct Absorption- and Wavelength Modulation-Spectroscopy

    Directory of Open Access Journals (Sweden)

    Alexander Klein

    2014-11-01

    Full Text Available We present a tunable diode laser spectrometer with a novel, rapid time multiplexed direct absorption- and wavelength modulation-spectroscopy operation mode. The new technique allows enhancing the precision and dynamic range of a tunable diode laser absorption spectrometer without sacrificing accuracy. The spectroscopic technique combines the benefits of absolute concentration measurements using calibration-free direct tunable diode laser absorption spectroscopy (dTDLAS with the enhanced noise rejection of wavelength modulation spectroscopy (WMS. In this work we demonstrate for the first time a 125 Hz time division multiplexed (TDM-dTDLAS-WMS spectroscopic scheme by alternating the modulation of a DFB-laser between a triangle-ramp (dTDLAS and an additional 20 kHz sinusoidal modulation (WMS. The absolute concentration measurement via the dTDLAS-technique allows one to simultaneously calibrate the normalized 2f/1f-signal of the WMS-technique. A dTDLAS/WMS-spectrometer at 1.37 µm for H2O detection was built for experimental validation of the multiplexing scheme over a concentration range from 50 to 3000 ppmV (0.1 MPa, 293 K. A precision of 190 ppbV was achieved with an absorption length of 12.7 cm and an averaging time of two seconds. Our results show a five-fold improvement in precision over the entire concentration range and a significantly decreased averaging time of the spectrometer.

  16. Asymptotic analysis of blood flow in stented arteries: time dependency and direct simulations***

    Directory of Open Access Journals (Sweden)

    Pichon Gostaf Kirill

    2010-12-01

    Full Text Available This work aims to extend in two distinct directions results recently obtained in [10]. In a first step we focus on the possible extension of our results to the time dependent case. Whereas in the second part some preliminary numerical simulations aim to give orders of magnitudes in terms of numerical costs of direct 3D simulations. We consider, in the first part, the time dependent rough problem for a simplified heat equation in a straight channel that mimics the axial velocity under an oscillating pressure gradient. We derive first order approximations with respect to ϵ, the size of the roughness. In order to understand the problem and set up correct boundary layer approximations, we perform a time periodic fourier analysis and check that no frequency can interact with the roughness. We show rigorously on this toy problem that the boundary layers remain stationary in time (independent on the frequency number. Finally we perform numerical tests validating our theoretical approach. In the second part, we determine actual limits, when running three-dimensional blood flow simulations of the non-homogenized stented arteries. We solve the stationary Stokes equations for an artery containing a saccular aneurysm. Consecutive levels of uniform mesh refinement, serve to relate spatial resolution, problem scale, and required computation time. Test computations are presented for femoral side aneurysm, where a simplified ten-wire stent model was placed across the aneurysm throat. We advocate the proposed stent homogenization model, by concluding that an actual computation power is not sufficient to run accurate, direct simulations of a pulsatile flow in stented vessels.

  17. How many or how much? Testing the relative influence of the number of social network risks versus the amount of time exposed to social network risks on post-treatment substance use.

    Science.gov (United States)

    Eddie, David; Kelly, John F

    2017-06-01

    Having high-risk, substance-using friends is associated with young adult substance use disorder (SUD) relapse. It is unclear, however, whether it is the total number of high-risk friends, or the amount of time spent with high-risk friends that leads to relapse. Unclear also, is to what extent low-risk friends buffer risk. This study examined the influence of number of high-risk and low-risk friends, and the amount time spent with these friends on post-treatment percent days abstinent (PDA). Young adult inpatients (N=302) were assessed at intake, and 3, 6, and 12 months on social network measures and PDA. Mixed models tested for effects of number of high- and low-risk friends, and time spent with these friends on PDA, and for net-risk friend effects to test whether low-risk friends offset risk. Within and across assessments, number of, and time spent with high-risk friends was negatively associated with PDA, while the inverse was true for low-risk friends. Early post-treatment, time spent with friends more strongly predicted PDA than number of friends. Participants were more deleteriously affected by time with high-risk friends the longer they were out of treatment, while contemporaneously protection conferred by low-risk friends increased. This interaction effect, however, was not observed with number of high- or low-risk friends, or number of friends net-risk. Young adult SUD patients struggling to break ties with high-risk friends should be encouraged to minimize time with them. Clinicians should also encourage patients to grow their social network of low-risk friends. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Comparative study on direct and indirect bracket bonding techniques regarding time length and bracket detachment

    Directory of Open Access Journals (Sweden)

    Jefferson Vinicius Bozelli

    2013-12-01

    Full Text Available OBJECTIVE: The aim of this study was to assess the time spent for direct (DBB - direct bracket bonding and indirect (IBB - indirect bracket bonding bracket bonding techniques. The time length of laboratorial (IBB and clinical steps (DBB and IBB as well as the prevalence of loose bracket after a 24-week follow-up were evaluated. METHODS: Seventeen patients (7 men and 10 women with a mean age of 21 years, requiring orthodontic treatment were selected for this study. A total of 304 brackets were used (151 DBB and 153 IBB. The same bracket type and bonding material were used in both groups. Data were submitted to statistical analysis by Wilcoxon non-parametric test at 5% level of significance. RESULTS: Considering the total time length, the IBB technique was more time-consuming than the DBB (p < 0.001. However, considering only the clinical phase, the IBB took less time than the DBB (p < 0.001. There was no significant difference (p = 0.910 for the time spent during laboratorial positioning of the brackets and clinical session for IBB in comparison to the clinical procedure for DBB. Additionally, no difference was found as for the prevalence of loose bracket between both groups. CONCLUSION: the IBB can be suggested as a valid clinical procedure since the clinical session was faster and the total time spent for laboratorial positioning of the brackets and clinical procedure was similar to that of DBB. In addition, both approaches resulted in similar frequency of loose bracket.

  19. Quantification and determinants of the amount of respiratory syncytial virus (RSV shed using real time PCR data from a longitudinal household study [version 2; referees: 2 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Miriam Wathuo

    2017-03-01

    Full Text Available Background A better understanding of respiratory syncytial virus (RSV epidemiology requires realistic estimates of RSV shedding patterns, quantities shed, and identification of the related underlying factors. Methods RSV infection data arise from a cohort study of 47 households with 493 occupants, in coastal Kenya, during the 2009/2010 RSV season. Nasopharyngeal swabs were taken every 3 to 4 days and screened for RSV using a real time polymerase chain reaction (PCR assay. The amount of virus shed was quantified by calculating the ‘area under the curve’ using the trapezoidal rule applied to rescaled PCR cycle threshold output. Multivariable linear regression was used to identify correlates of amount of virus shed. Results The median quantity of virus shed per infection episode was 29.4 (95% CI: 15.2, 54.2 log10 ribonucleic acid (RNA copies * days. Young age (<1 year, presence of upper respiratory symptoms, intra-household acquisition of infection, an individual’s first infection episode in the RSV season, and having a co-infection of RSV group A and B were associated with increased amount of virus shed. Conclusions The findings provide insight into which groups of individuals have higher potential for transmission, information which may be useful in designing RSV prevention strategies.

  20. Chemical discrimination of lubricant marketing types using direct analysis in real time time-of-flight mass spectrometry.

    Science.gov (United States)

    Maric, Mark; Harvey, Lauren; Tomcsak, Maren; Solano, Angelique; Bridge, Candice

    2017-06-30

    In comparison to other violent crimes, sexual assaults suffer from very low prosecution and conviction rates especially in the absence of DNA evidence. As a result, the forensic community needs to utilize other forms of trace contact evidence, like lubricant evidence, in order to provide a link between the victim and the assailant. In this study, 90 personal bottled and condom lubricants from the three main marketing types, silicone-based, water-based and condoms, were characterized by direct analysis in real time time of flight mass spectrometry (DART-TOFMS). The instrumental data was analyzed by multivariate statistics including hierarchal cluster analysis, principal component analysis, and linear discriminant analysis. By interpreting the mass spectral data with multivariate statistics, 12 discrete groupings were identified, indicating inherent chemical diversity not only between but within the three main marketing groups. A number of unique chemical markers, both major and minor, were identified, other than the three main chemical components (i.e. PEG, PDMS and nonoxynol-9) currently used for lubricant classification. The data was validated by a stratified 20% withheld cross-validation which demonstrated that there was minimal overlap between the groupings. Based on the groupings identified and unique features of each group, a highly discriminating statistical model was then developed that aims to provide the foundation for the development of a forensic lubricant database that may eventually be applied to casework. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  1. A combination of HARMONIE short time direct normal irradiance forecasts and machine learning: The #hashtdim procedure

    Science.gov (United States)

    Gastón, Martín; Fernández-Peruchena, Carlos; Körnich, Heiner; Landelius, Tomas

    2017-06-01

    The present work describes the first approach of a new procedure to forecast Direct Normal Irradiance (DNI): the #hashtdim that treats to combine ground information and Numerical Weather Predictions. The system is centered in generate predictions for the very short time. It combines the outputs from the Numerical Weather Prediction Model HARMONIE with an adaptive methodology based on Machine Learning. The DNI predictions are generated with 15-minute and hourly temporal resolutions and presents 3-hourly updates. Each update offers forecasts to the next 12 hours, the first nine hours are generated with 15-minute temporal resolution meanwhile the last three hours present hourly temporal resolution. The system is proved over a Spanish emplacement with BSRN operative station in south of Spain (PSA station). The #hashtdim has been implemented in the framework of the Direct Normal Irradiance Nowcasting methods for optimized operation of concentrating solar technologies (DNICast) project, under the European Union's Seventh Programme for research, technological development and demonstration framework.

  2. Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.

    Directory of Open Access Journals (Sweden)

    Michael C Weiger

    Full Text Available Cancer cells alter their migratory properties during tumor progression to invade surrounding tissues and metastasize to distant sites. However, it remains unclear how migratory behaviors differ between tumor cells of different malignancy and whether these migratory behaviors can be utilized to assess the malignant potential of tumor cells. Here, we analyzed the migratory behaviors of cell lines representing different stages of breast cancer progression using conventional migration assays or time-lapse imaging and particle image velocimetry (PIV to capture migration dynamics. We find that the number of migrating cells in transwell assays, and the distance and speed of migration in unconstrained 2D assays, show no correlation with malignant potential. However, the directionality of cell motion during 2D migration nicely distinguishes benign and tumorigenic cell lines, with tumorigenic cell lines harboring less directed, more random motion. Furthermore, the migratory behaviors of epithelial sheets observed under basal conditions and in response to stimulation with epidermal growth factor (EGF or lysophosphatitic acid (LPA are distinct for each cell line with regard to cell speed, directionality, and spatiotemporal motion patterns. Surprisingly, treatment with LPA promotes a more cohesive, directional sheet movement in lung colony forming MCF10CA1a cells compared to basal conditions or EGF stimulation, implying that the LPA signaling pathway may alter the invasive potential of MCF10CA1a cells. Together, our findings identify cell directionality as a promising indicator for assessing the tumorigenic potential of breast cancer cell lines and show that LPA induces more cohesive motility in a subset of metastatic breast cancer cells.

  3. Fiber-reinforced concretes with a high fiber volume fraction — a look in future. Can a design determine the fiber amount in concrete in real time in every part of a structure in production?

    Science.gov (United States)

    Tepfers, R.

    2010-09-01

    In near future, when the control of the load-bearing capacity of fiber-only-reinforced concrete members will be safely guaranteed, the deletion of the ordinary continuous steel reinforcing bars might be possible. For the time being, it is difficult to change the fiber amount during the casting with today's techniques. Therefore, the fiber concentration has to be determined by the maximum tensile stress in concrete structural members, resulting in an unnecessary fiber addition in compressed zones. However, if the right amount of fibers could be regulated and added to concrete in real time at the pump outlet, a future vision could be to design and produce a structure by using FEM-controlled equipment. The signals from calculation results could be transmitted to a concrete casting system for addition of a necessary amount of fibers to take care of the actual tensile stresses in the right position in the structure. The casting location could be determined by using a GPS for positioning the pump outlet for targeting the casting location horizontally and a laser vertically. The addition of fibers to concrete at the outlet of a concrete pump and proportioning them there according to the actual needs of the stress situation in a structure, given by a FEM analysis in real time, is a future challenge. The FEM analysis has to be based on material properties of fiber-only-reinforced concrete. This means that the resistance and stiffness of different-strength concrete members with a varying fiber content has to be determined in tests and conveyed to the FEM analysis. The FEM analysis has to be completed before the casting and controlled. Then it can be used as the base for adding a correct amount of fibers to concrete in every part of the structure. Thus, a system for introducing a correct amount of fibers into concrete has to be developed. The fibers have to be added at the outlet of concrete pump. Maybe a system to shotcrete concrete with electronically controlled fiber

  4. Real-time decreased sensitivity to an audio-visual illusion during goal-directed reaching.

    Directory of Open Access Journals (Sweden)

    Luc Tremblay

    Full Text Available In humans, sensory afferences are combined and integrated by the central nervous system (Ernst MO, Bülthoff HH (2004 Trends Cogn. Sci. 8: 162-169 and appear to provide a holistic representation of the environment. Empirical studies have repeatedly shown that vision dominates the other senses, especially for tasks with spatial demands. In contrast, it has also been observed that sound can strongly alter the perception of visual events. For example, when presented with 2 flashes and 1 beep in a very brief period of time, humans often report seeing 1 flash (i.e. fusion illusion, Andersen TS, Tiippana K, Sams M (2004 Brain Res. Cogn. Brain Res. 21: 301-308. However, it is not known how an unfolding movement modulates the contribution of vision to perception. Here, we used the audio-visual illusion to demonstrate that goal-directed movements can alter visual information processing in real-time. Specifically, the fusion illusion was linearly reduced as a function of limb velocity. These results suggest that cue combination and integration can be modulated in real-time by goal-directed behaviors; perhaps through sensory gating (Chapman CE, Beauchamp E (2006 J. Neurophysiol. 96: 1664-1675 and/or altered sensory noise (Ernst MO, Bülthoff HH (2004 Trends Cogn. Sci. 8: 162-169 during limb movements.

  5. The European Working Time Directive: a practical review for surgical trainees.

    Science.gov (United States)

    Fitzgerald, J E F; Caesar, B C

    2012-01-01

    The European Working Time Directive (EWTD) 2003/88/EC is a Union Directive laying down minimum health and safety requirements for the organisation of working time. Originally primarily intended as labour law, its progressive introduction up to full implementation for doctors-in-training in August 2009 has substantially reduced duty-hours and caused widespread concern in surgery. Detrimental effects on the continuity of patient care, reduced availability of medical staff with associated rota difficulties, and the reduction in time for training junior doctors have been widely cited. Craft-specialities such as surgery and those providing an acute service have faced particular challenges. This review offers a practical guide for surgical trainees, explaining the European regulations in the context of current terms and conditions of doctor's employment in the UK. Information is provided on protecting training, opting-out, seeking remuneration for this, and ensuring doctors and patients are protected with appropriate medical indemnity cover in place. Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  6. Effect of parameter calculation in direct estimation of the Lyapunov exponent in short time series

    Directory of Open Access Journals (Sweden)

    A. M. López Jiménez

    2002-01-01

    Full Text Available The literature about non-linear dynamics offers a few recommendations, which sometimes are divergent, about the criteria to be used in order to select the optimal calculus parameters in the estimation of Lyapunov exponents by direct methods. These few recommendations are circumscribed to the analysis of chaotic systems. We have found no recommendation for the estimation of λ starting from the time series of classic systems. The reason for this is the interest in distinguishing variability due to a chaotic behavior of determinist dynamic systems of variability caused by white noise or linear stochastic processes, and less in the identification of non-linear terms from the analysis of time series. In this study we have centered in the dependence of the Lyapunov exponent, obtained by means of direct estimation, of the initial distance and the time evolution. We have used generated series of chaotic systems and generated series of classic systems with varying complexity. To generate the series we have used the logistic map.

  7. Automated and angular time-synchronized directional gamma-ray scintillation sensor

    International Nuclear Information System (INIS)

    Kronenberg, S.; Brucker, G.J.

    1998-01-01

    The authors' previous research resulted in directional sensors for gamma rays and X rays that have a 4π solid angle of acceptance and, at the same time, a high angular resolution that is limited only by their ability to measure small angles. Angular resolution of ∼1 s of arc was achieved. These sensors are capable of operating and accurately detecting high and very low intensity radiation patterns. Such a system can also be used to image broad area sources and their scattering patterns. The principle of operation and design of directional sensors used in this study was described elsewhere; however, for convenience, a part of that text is repeated here. It was shown analytically that the angular distribution of radiation incident on the sensor is proportional to the first derivative of the scan data, that is, of the events' count rate versus orientation of the detector. The previously published results were obtained with a annual operating system. The detector assembly was set at a specific angle, and a pulse rate count was made. This was repeated at numerous other angles of orientation, a time-consuming and labor-intensive process. Recently, the authors automated this system, which is based on the detection of scintillations. The detector, which consists of a stack of plates of Lucite, plastic scintillator, and lead foils, rotates by means of a motor in front of a stationary photomultiplier tube (PMT). One revolution per second was chosen for the motor. At time zero, a trigger indicates that a revolution has started. The angle of orientation of the detector in the laboratory system is proportional to the time during one revolution. The process repeats itself a desired number of times. The trigger signal initiates a scan of a multichannel scalar (MCS). The detector assembly is allowed to rotate in the radiation field, and the MCS scans are repeated in an accumulated mode of operation until enough events are collected for the location of the radiation source to be

  8. Re-inventing electromagnetics - Supercomputing solution of Maxwell's equations via direct time integration on space grids

    International Nuclear Information System (INIS)

    Taflove, A.

    1992-01-01

    This paper summarizes the present state and future directions of applying finite-difference and finite-volume time-domain techniques for Maxwell's equations on supercomputers to model complex electromagnetic wave interactions with structures. Applications so far have been dominated by radar cross section technology, but by no means are limited to this area. In fact, the gains we have made place us on the threshold of being able to make tremendous contributions to non-defense electronics and optical technology. Some of the most interesting research in these commercial areas is summarized. 47 refs

  9. Generalized direct Lyapunov method for the analysis of stability and attraction in general time systems

    International Nuclear Information System (INIS)

    Druzhinina, O V; Shestakov, A A

    2002-01-01

    A generalized direct Lyapunov method is put forward for the study of stability and attraction in general time systems of the following types: the classical dynamical system in the sense of Birkhoff, the general system in the sense of Zubov, the general system in the sense of Seibert, the general system with delay, and the general 'input-output' system. For such systems, with the help of generalized Lyapunov functions with respect to two filters, two quasifilters, or two filter bases, necessary and sufficient conditions for stability and attraction are obtained under minimal assumptions about the mathematical structure of the general system

  10. Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Rimmerman, Dolev [Department; Leshchev, Denis [Department; Hsu, Darren J. [Department; Hong, Jiyun [Department; Kosheleva, Irina [Center; Chen, Lin X. [Department; Chemical

    2017-09-05

    Biological functions frequently require protein-protein interactions that involve secondary and tertiary structural perturbation. Here we study protein-protein dissociation and reassociation dynamics in insulin, a model system for protein oligomerization. Insulin dimer dissociation into monomers was induced by a nanosecond temperature-jump (T-jump) of ~8 °C in aqueous solution, and the resulting protein and solvent dynamics were tracked by time-resolved X-ray solution scattering (TRXSS) on time scales of 10 ns to 100 ms. The protein scattering signals revealed the formation of five distinguishable transient species during the association process that deviate from simple two state kinetics. Our results show that the combination of T-jump pump coupled to TRXSS probe allows for direct tracking of structural dynamics in nonphotoactive proteins.

  11. Validation of the direct analysis in real time source for use in forensic drug screening.

    Science.gov (United States)

    Steiner, Robert R; Larson, Robyn L

    2009-05-01

    The Direct Analysis in Real Time (DART) ion source is a relatively new mass spectrometry technique that is seeing widespread use in chemical analyses world-wide. DART studies include such diverse topics as analysis of flavors and fragrances, melamine in contaminated dog food, differentiation of writing inks, characterization of solid counterfeit drugs, and as a detector for planar chromatography. Validation of this new technique for the rapid screening of forensic evidence for drugs of abuse, utilizing the DART source coupled to an accurate mass time-of-flight mass spectrometer, was conducted. The study consisted of the determination of the lower limit of detection for the method, determination of selectivity and a comparison of this technique to established analytical protocols. Examples of DART spectra are included. The results of this study have allowed the Virginia Department of Forensic Science to incorporate this new technique into their analysis scheme for the screening of solid dosage forms of drugs of abuse.

  12. Direct and real time probe of photoinduced structure transition in colossal magnetoresistive material

    Energy Technology Data Exchange (ETDEWEB)

    Li, Junjie [Physics Department, Florida State University, Tallahassee, Florida 32310 (United States); National High Magnetic Field Laboratory, Tallahassee, Florida 32310 (United States); Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Wang, Xuan [Institute of physics, Chinese Academy of Sciences, P.O. Box 603, Beijing 100190 (China); Zhou, Haidong [National High Magnetic Field Laboratory, Tallahassee, Florida 32310 (United States); Zhou, Jun; Cao, Jianming, E-mail: jcao@magnet.fsu.edu [Physics Department, Florida State University, Tallahassee, Florida 32310 (United States); National High Magnetic Field Laboratory, Tallahassee, Florida 32310 (United States); Cheng, J. G. [Texas Materials Institute, University of Texas at Austin, Austin, Texas 78712 (United States)

    2016-07-25

    We report a direct and real time measurement of photoinduced structure phase transition in single crystal La{sub 0.84}Sr{sub 0.16}MnO{sub 3} using femtosecond electron diffraction. The melting of orthorhombic lattice ordering under femtosecond optical excitation is found involving two distinct processes with different time scales, an initial fast melting of orthorhombic phase in about 4 ps and a subsequent slower transformation in 90 ps and longer timescales. The fast process is designated as the initial melting of orthorhombic phase induced by the Mn-O bond change that is most likely driven by the quenching of the dynamic Jahn-Teller distortion following the photo-excitation. The slow process is attributed to the growing of newly formed structure domain from the photo-excited sites to the neighboring non-excited orthorhombic sites.

  13. Determinants Of Foreign Direct Investment In Mauritius Evidence From Time Series Data

    Directory of Open Access Journals (Sweden)

    Medha Kisto

    2017-08-01

    Full Text Available Over the last two decades Foreign Direct Investment FDI claimed an impressive economic record as it enables economy to transit from an agrarian to knowledge based economy. This paper focuses on the determinants and impact of FDI in Mauritius using annual time series data from 1975 through 2015. The Vector Error Correction Model VECM analysis reveals that macroeconomic variables namely inflation rates and exchange rate are among the major and important factor that affect FDI in Mauritius over this period of time. Exchange rate exhibited negative significant influence on FDI while interest rate affects FDI positively. The study therefore recommends that government should continue to diversify the export and tourism markets ensure stable macroeconomic policies implement reforms on doing business increase its expenditure in the area of infrastructural development and redirect FDI in productive sector of the economy as ways to accelerate the growth of Mauritian economy.

  14. Real-time dynamic analysis for complete loop of direct steam generation solar trough collector

    International Nuclear Information System (INIS)

    Guo, Su; Liu, Deyou; Chu, Yinghao; Chen, Xingying; Shen, Bingbing; Xu, Chang; Zhou, Ling; Wang, Pei

    2016-01-01

    Highlights: • A nonlinear distribution parameter dynamic model has been developed. • Real-time local heat transfer coefficient and friction coefficient are adopted. • The dynamic behavior of the solar trough collector loop are simulated. • High-frequency chattering of outlet fluid flow are analyzed and modeled. • Irradiance disturbance at subcooled water region generates larger influence. - Abstract: Direct steam generation is a potential approach to further reduce the levelized electricity cost of solar trough. Dynamic modeling of the collector loop is essential for operation and control of direct steam generation solar trough. However, the dynamic behavior of fluid based on direct steam generation is complex because of the two-phase flow in the pipeline. In this work, a nonlinear distribution parameter model has been developed to model the dynamic behaviors of direct steam generation parabolic trough collector loops under either full or partial solar irradiance disturbance. Compared with available dynamic model, the proposed model possesses two advantages: (1) real-time local values of heat transfer coefficient and friction resistance coefficient, and (2) considering of the complete loop of collectors, including subcooled water region, two-phase flow region and superheated steam region. The proposed model has shown superior performance, particularly in case of sensitivity study of fluid parameters when the pipe is partially shaded. The proposed model has been validated using experimental data from Solar Thermal Energy Laboratory of University of New South Wales, with an outlet fluid temperature relative error of only 1.91%. The validation results show that: (1) The proposed model successfully outperforms two reference models in predicting the behavior of direct steam generation solar trough. (2) The model theoretically predicts that, during solar irradiance disturbance, the discontinuities of fluid physical property parameters and the moving back and

  15. Impact of the European Working Time Directive (EWTD) on the operative experience of surgery residents.

    Science.gov (United States)

    Hopmans, Cornelis J; den Hoed, Pieter T; van der Laan, Lijckle; van der Harst, Erwin; van der Elst, Maarten; Mannaerts, Guido H H; Dawson, Imro; Timman, Reinier; Wijnhoven, Bas P L; IJzermans, Jan N M

    2015-04-01

    In Europe and the United States, work hour restrictions are considered to be particularly burdensome for residents in surgery specialties. The aim of this study was to examine whether reduction of the work week to 48 hours resulting from the implementation of the European Working Time Directive has affected the operative experience of surgery residents. This study was conducted in a general surgery training region in the Netherlands, consisting of 1 university hospital and 6 district training hospitals. Operating records summarizing the surgical procedures performed as "primary surgeon" in the operating theater for different grades of surgeons were retrospectively analyzed for the period 2005-2012 by the use of linear regression models. Operative procedures performed by residents were considered the main outcome measure. In total, 235,357 operative procedures were performed, including 47,458 (20.2%) in the university hospital and 187,899 (79.8%) in the district training hospitals (n = 5). For residents in the university hospital, the mean number of operative procedures performed per 1.0 full-time equivalent increased from 128 operations in 2005 to 204 operations in 2012 (P = .001), whereas for residents in district training hospitals, no substantial differences were found over time. The mean (±SD) operative caseload of 64 residents who completed the 6-year training program between 2005 and 2012 was 1,391 ± 226 (range, 768-1856). A comparison of the operative caseload according to year of board-certification showed no difference. Implementation of the European Working Time Directive has not affected adversely the number of surgical procedures performed by residents within a general surgical training region in the Netherlands. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Just-in-Time Video Laryngoscopy Versus Direct Laryngoscopy for Neonatal Intubation.

    Science.gov (United States)

    Grgurich, Erin; Arnemann, Cynthia; Amon, Kim; Horton, Rose; Carlson, Jestin N

    As neonatal endotracheal intubation (ETI) is a low-frequency, high-consequence event, it is essential that providers have access to resources to aid in ETI. We sought to determine the impact of video laryngoscopy (VL) with just-in-time training on intubation outcomes over direct laryngoscopy (DL) when performed by neonatal nurses. We conducted a prospective, randomized, crossover study with neonatal nurses employed at a level 2 neonatal intensive care unit (NICU). Nurses performed both DL and VL on a neonatal mannequin using a CMAC (Karl Storz Corp, Tuttlingen, Germany) either with the assistance of the screen (VL) or without (DL). Before performing the intubation, providers were given a just-in-time, brief education presentation and allowed to practice with the device. Each ETI attempt was reviewed to obtain the percentage of glottic opening (POGO) score, time to intubation (TTI, time from insertion of the blade into the mouth until the first breath was delivered), and time from blade insertion until the best POGO score. We enrolled 19 participants, with a median (interquartile range) of 20 (9-26) years of experience and having a median of 2 (1-3) intubations within the past year. None had used VL in the NICU previously. Median TTI did not differ between DL and VL: 19.9 (15.3-41.5) vs 20.3 (17.9-24.4) (P = 1). POGO scores and the number of attempts also did not differ between DL and VL. In our simulated setting, just-in-time VL training provided similar intubation outcomes compared with DL in ETI performed by neonatal nurses. Just-in-time VL education may be an alternative to traditional DL for neonatal intubations.

  17. Using linear time-invariant system theory to estimate kinetic parameters directly from projection measurements

    International Nuclear Information System (INIS)

    Zeng, G.L.; Gullberg, G.T.

    1995-01-01

    It is common practice to estimate kinetic parameters from dynamically acquired tomographic data by first reconstructing a dynamic sequence of three-dimensional reconstructions and then fitting the parameters to time activity curves generated from the time-varying reconstructed images. However, in SPECT, the pharmaceutical distribution can change during the acquisition of a complete tomographic data set, which can bias the estimated kinetic parameters. It is hypothesized that more accurate estimates of the kinetic parameters can be obtained by fitting to the projection measurements instead of the reconstructed time sequence. Estimation from projections requires the knowledge of their relationship between the tissue regions of interest or voxels with particular kinetic parameters and the project measurements, which results in a complicated nonlinear estimation problem with a series of exponential factors with multiplicative coefficients. A technique is presented in this paper where the exponential decay parameters are estimated separately using linear time-invariant system theory. Once the exponential factors are known, the coefficients of the exponentials can be estimated using linear estimation techniques. Computer simulations demonstrate that estimation of the kinetic parameters directly from the projections is more accurate than the estimation from the reconstructed images

  18. Early years neurosurgical training in the era of the European Working Time Directive.

    Science.gov (United States)

    Kirkman, Matthew A; Watkins, Laurence D; Kitchen, Neil D; Sethi, Huma

    2013-10-01

    The past decade has seen significant changes to the face of neurosurgical training in the United Kingdom, driven in part by an increasing focus on patient safety and the introduction of Modernising Medical Careers and the European Working Time Directive (EWTD). Recent reforms to neurosurgical training over the past few years have resulted in creation of an 8-year 'run-through' training programme. In this programme, early years (ST1 and ST2) trainees often lack dedicated time for elective theatre lists and outpatient clinics. Further, any time spent in theatre and clinics is often with different teams. Here we describe a training model for early years trainees at the National Hospital for Neurology and Neurosurgery, who are given the responsibilities traditionally associated with a more senior trainee including dedicated weekly theatre and clinic time under the supervision of a single consultant, in addition to out of hours experience. The advantages and considerations for implementing this model are discussed, including the benefit of guidance under a single consultant in the early stages of training, along with key educational concepts necessary for understanding its utility. We feel that this is an effective model for junior neurosurgical training in the EWTD era, expediting the trainee's development of key technical and non-technical skills, with potentially significant rewards for patient, trainee and trainer. National implementation of this model should be considered.

  19. CMOS direct time interval measurement of long-lived luminescence lifetimes.

    Science.gov (United States)

    Yao, Lei; Yung, Ka Yi; Cheung, Maurice C; Chodavarapu, Vamsy P; Bright, Frank V

    2011-01-01

    We describe a Complementary Metal-Oxide Semiconductor (CMOS) Direct Time Interval Measurement (DTIM) Integrated Circuit (IC) to detect the decay (fall) time of the luminescence emission when analyte-sensitive luminophores are excited with an optical pulse. The CMOS DTIM IC includes 14 × 14 phototransistor array, transimpedance amplifier, regulated gain amplifier, fall time detector, and time-to-digital convertor. We examined the DTIM system to measure the emission lifetime of oxygen-sensitive luminophores tris(4,7-diphenyl-1, 10-phenanthroline) ruthenium(II) ([Ru(dpp)(3)](2+)) encapsulated in sol-gel derived xerogel thin-films. The DTIM system fabricated using TSMC 0.35 μm process functions to detect lifetimes from 4 μs to 14.4 μs but can be tuned to detect longer lifetimes. The system provides 8-bit digital output proportional to lifetimes and consumes 4.5 mW of power with 3.3 V DC supply. The CMOS system provides a useful platform for the development of reliable, robust, and miniaturized optical chemical sensors.

  20. Timing-Constrained FPGA Placement: A Force-Directed Formulation and Its Performance Evaluation

    Directory of Open Access Journals (Sweden)

    Srilata Raman

    1996-01-01

    Full Text Available In this paper we present a simple but efficient timing-driven placement algorithm for FPGAs. The algorithm computes forces acting on a logic block in the FPGA to determine its relative location with respect to other blocks. The forces depend on the criticality of nets shared between the two blocks. Unlike other net-based approaches, timing constraints are incorporated directly into the force equations to guide the placement. Slot assignment is then used to move the blocks into valid slot locations on the FPGA chip. The assignment algorithm also makes use of the delay information of nets so that the final placement is able to meet the timing criteria specified for the circuit. The novelty of the approach lies in the formulation of the force equations and the manner in which weights of the nets are dynamically altered to influence the placement. Experiments conducted on industrial test circuits and MCNC circuits give very promising results and indicate that the algorithm succeeds in significantly reducing the maximum delay in the circuit. In addition, routability is not adversely affected and running time is low.

  1. Real-time ultrasound image classification for spine anesthesia using local directional Hadamard features.

    Science.gov (United States)

    Pesteie, Mehran; Abolmaesumi, Purang; Ashab, Hussam Al-Deen; Lessoway, Victoria A; Massey, Simon; Gunka, Vit; Rohling, Robert N

    2015-06-01

    Injection therapy is a commonly used solution for back pain management. This procedure typically involves percutaneous insertion of a needle between or around the vertebrae, to deliver anesthetics near nerve bundles. Most frequently, spinal injections are performed either blindly using palpation or under the guidance of fluoroscopy or computed tomography. Recently, due to the drawbacks of the ionizing radiation of such imaging modalities, there has been a growing interest in using ultrasound imaging as an alternative. However, the complex spinal anatomy with different wave-like structures, affected by speckle noise, makes the accurate identification of the appropriate injection plane difficult. The aim of this study was to propose an automated system that can identify the optimal plane for epidural steroid injections and facet joint injections. A multi-scale and multi-directional feature extraction system to provide automated identification of the appropriate plane is proposed. Local Hadamard coefficients are obtained using the sequency-ordered Hadamard transform at multiple scales. Directional features are extracted from local coefficients which correspond to different regions in the ultrasound images. An artificial neural network is trained based on the local directional Hadamard features for classification. The proposed method yields distinctive features for classification which successfully classified 1032 images out of 1090 for epidural steroid injection and 990 images out of 1052 for facet joint injection. In order to validate the proposed method, a leave-one-out cross-validation was performed. The average classification accuracy for leave-one-out validation was 94 % for epidural and 90 % for facet joint targets. Also, the feature extraction time for the proposed method was 20 ms for a native 2D ultrasound image. A real-time machine learning system based on the local directional Hadamard features extracted by the sequency-ordered Hadamard transform for

  2. Biomechanical factors associated with time to complete a change of direction cutting maneuver.

    Science.gov (United States)

    Marshall, Brendan M; Franklyn-Miller, Andrew D; King, Enda A; Moran, Kieran A; Strike, Siobhán C; Falvey, Éanna C

    2014-10-01

    Cutting ability is an important aspect of many team sports, however, the biomechanical determinants of cutting performance are not well understood. This study aimed to address this issue by identifying the kinetic and kinematic factors correlated with the time to complete a cutting maneuver. In addition, an analysis of the test-retest reliability of all biomechanical measures was performed. Fifteen (n = 15) elite multidirectional sports players (Gaelic hurling) were recruited, and a 3-dimensional motion capture analysis of a 75° cut was undertaken. The factors associated with cutting time were determined using bivariate Pearson's correlations. Intraclass correlation coefficients (ICCs) were used to examine the test-retest reliability of biomechanical measures. Five biomechanical factors were associated with cutting time (2.28 ± 0.11 seconds): peak ankle power (r = 0.77), peak ankle plantar flexor moment (r = 0.65), range of pelvis lateral tilt (r = -0.54), maximum thorax lateral rotation angle (r = 0.51), and total ground contact time (r = -0.48). Intraclass correlation coefficient scores for these 5 factors, and indeed for the majority of the other biomechanical measures, ranged from good to excellent (ICC >0.60). Explosive force production about the ankle, pelvic control during single-limb support, and torso rotation toward the desired direction of travel were all key factors associated with cutting time. These findings should assist in the development of more effective training programs aimed at improving similar cutting performances. In addition, test-retest reliability scores were generally strong, therefore, motion capture techniques seem well placed to further investigate the determinants of cutting ability.

  3. Algorithm for determining two-periodic steady-states in AC machines directly in time domain

    Directory of Open Access Journals (Sweden)

    Sobczyk Tadeusz J.

    2016-09-01

    Full Text Available This paper describes an algorithm for finding steady states in AC machines for the cases of their two-periodic nature. The algorithm enables to specify the steady-state solution identified directly in time domain despite of the fact that two-periodic waveforms are not repeated in any finite time interval. The basis for such an algorithm is a discrete differential operator that specifies the temporary values of the derivative of the two-periodic function in the selected set of points on the basis of the values of that function in the same set of points. It allows to develop algebraic equations defining the steady state solution reached in a chosen point set for the nonlinear differential equations describing the AC machines when electrical and mechanical equations should be solved together. That set of those values allows determining the steady state solution at any time instant up to infinity. The algorithm described in this paper is competitive with respect to the one known in literature an approach based on the harmonic balance method operated in frequency domain.

  4. One Improvement Method of Reducing Duration Directly to Solve Time-Cost Tradeoff Problem

    Science.gov (United States)

    Jian-xun, Qi; Dedong, Sun

    Time and cost are two of the most important factors for project plan and schedule management, and specially, time-cost tradeoff problem is one classical problem in project scheduling, which is also a difficult problem. Methods of solving the problem mainly contain method of network flow and method of mending the minimal cost. Thereinto, for the method of mending the minimal cost is intuitionistic, convenient and lesser computation, these advantages make the method being used widely in practice. But disadvantage of the method is that the result of each step is optimal but the terminal result maybe not optimal. In this paper, firstly, method of confirming the maximal effective quantity of reducing duration is designed; secondly, on the basis of above method and the method of mending the minimal cost, the main method of reducing duration directly is designed to solve time-cost tradeoff problem, and by analyzing validity of the method, the method could obtain more optimal result for the problem.

  5. Detection of Low Molecular Weight Adulterants in Beverages by Direct Analysis in Real Time Mass Spectrometry.

    Science.gov (United States)

    Sisco, Edward; Dake, Jeffrey

    2016-04-14

    Direct Analysis in Real Time Mass Spectrometry (DART-MS) has been used to detect the presence of non-narcotic adulterants in beverages. The non-narcotic adulterants that were examined in this work incorporated a number low molecular weight alcohols, acetone, ammonium hydroxide, and sodium hypochlorite. Analysis of the adulterants was completed by pipetting 1 µL deposits onto glass microcapillaries along with an appropriate dopant species followed by introduction into the DART gas stream. It was found that detection of these compounds in the complex matrices of common beverages (soda, energy drinks, etc.) was simplified through the use of a dopant species to allow for adduct formation with the desired compound(s) of interest. Other parameters that were investigated included DART gas stream temperature, in source collision induced dissociation, ion polarity, and DART needle voltage. Sensitivities of the technique were found to range from 0.001 % volume fraction to 0.1 % volume fraction, comparable to traditional analyses completed using headspace gas chromatography mass spectrometry (HS-GC/MS). Once a method was established using aqueous solutions, , fifteen beverages were spiked with each of the nine adulterants, to simulate real world detection, and in nearly all cases the adulterant could be detected either in pure form, or complexed with the added dopant species. This technique provides a rapid way to directly analyze beverages believed to be contaminated with non-narcotic adulterants at sensitivities similar to or exceeding those of traditional confirmatory analyses.

  6. Experimental search for a time-modulated muon flux from the direction of Cygnus X-3

    International Nuclear Information System (INIS)

    Worstell, W.A.

    1986-01-01

    Two underground experiments have recently reported detection of an anomalously large muon flux from the direction of the binary X-ray source cygnus X-3, with the 4.8-hour period characteristic of this source. A muon flux of the claimed magnitude, combined with constraints from surface observations, is inconsistent with the production of these muons by photons from Cygnus X-3 in normal air showers. This flux would require either unexpected photon interactions at very high energy (>5 TeV)( or a new type of neutral particle in the flux from Cygnus X-3. This thesis documents measurements with the HPW (Harvard-Purdue-Wisconsin) large underground water Cerenkov detector which do not confirm the claimed muon flux. The author places an upper limit on the flux of time-modulated muons from the direction of Cygnus X-3 of 5 x 10 -11 muons-cm -2 sec -1 at a vertical depth of 1450 MWE meters of water equivalent, with 90% confidence. This upper limit may be compared with the flux of 7 x 10 -11 muons-cm 2 sec -1 at a vertical depth of 1800 MWE which was claimed by another experiment. The HPW measurements are consistent with no anomalous muon flux from Cygnus X-3

  7. Direct prediction of spatially and temporally varying physical properties from time-lapse electrical resistance data

    Science.gov (United States)

    Hermans, Thomas; Oware, Erasmus; Caers, Jef

    2016-09-01

    Time-lapse applications of electrical methods have grown significantly over the last decade. However, the quantitative interpretation of tomograms in terms of physical properties, such as salinity, temperature or saturation, remains difficult. In many applications, geophysical models are transformed into hydrological models, but this transformation suffers from spatially and temporally varying resolution resulting from the regularization used by the deterministic inversion. In this study, we investigate a prediction-focused approach (PFA) to directly estimate subsurface physical properties with electrical resistance data, circumventing the need for classic tomographic inversions. First, we generate a prior set of resistance data and physical property forecast through hydrogeological and geophysical simulations mimicking the field experiment. We reduce the dimension of both the data and the forecast through principal component analysis in order to keep the most informative part of both sets in a reduced dimension space. Then, we apply canonical correlation analysis to explore the relationship between the data and the forecast in their reduced dimension space. If a linear relationship can be established, the posterior distribution of the forecast can be directly sampled using a Gaussian process regression where the field data scores are the conditioning data. In this paper, we demonstrate PFA for various physical property distributions. We also develop a framework to propagate the estimated noise level in the reduced dimension space. We validate the results by a Monte Carlo study on the posterior distribution and demonstrate that PFA yields accurate uncertainty for the cases studied.

  8. European Working Time Directive: Implementation across -Europe and consequences upon training in obstetrics and -gynaecology.

    Science.gov (United States)

    Pärgmäe, P; Martins, N; Rodríguez, D; Christopoulos, P; Werner, H M J

    2011-01-01

    To review the compliance of the European Working Time Directive (EWTD) in different teaching hospitals across Europe and its consequences upon training. It is an observational, descriptive, cross-sectional study. The sample is constituted by the answers from trainees selected by the representatives of 29 European Network of Trainees in Ob/Gyn (ENTOG) member countries to a survey designed by ENTOG Executive. The survey content was based on a joint survey by the Royal College of Obstetricians and Gynaecologists (RCOG) and the Royal College for Paediatrics (RCP), carried out in 2008, but adapted for use on a European level. An answer rate of 75% was obtained. Only 5 countries out of 29 were compliant with EWTD two months before the compulsory adherence. Countries needed to introduce 1 to 4 changes to the system to make the rotas -compliant. Positive effect on work and private life balance was noticed in 87% from all responses. Trainees notice the need to further improve training programmes in order to have the same quality of training and continuous care of patients. Steps forward to implement EWTD are being made. Trainees should be involved with the introduction to optimize training conditions under the EWTD. Countries that still struggle to introduce the directive may learn from countries that already are compliant. It is suggested to organize a survey on senior society level to gain additional information to further investigate the effects on training quality and patient care.

  9. Direct look from a predator shortens the risk-assessment time by prey.

    Directory of Open Access Journals (Sweden)

    Sang-im Lee

    Full Text Available Decision making process is an important component of information use by animals and has already been studied in natural situations. Decision making takes time, which is expressed as a cost in evolutionary explanations of decision making abilities of animals. However, the duration of information assessment and decision making process has not been measured in a natural situation. Here, we use responses of wild magpies (Pica pica to predictably approaching humans to demonstrate that, regardless of whether the bird perceived high (decided to fly away or low (resumed foraging threat level, the bird assessed the situation faster when approaching humans looked directly at it than when the humans were not directly looking at it. This indicates that prey is able to extract more information about the predator's intentions and to respond sooner when the predator is continuously ("intently" looking at the prey. The results generally illustrate how an increase of information available to an individual leads to a shorter assessment and decision making process, confirming one of central tenets of psychology of information use in a wild bird species in its natural habitat.

  10. Directional absorption by phased arrays of plasmonic nanoantennae probed with time-reversed Fourier microscopy

    International Nuclear Information System (INIS)

    Lozano, Gabriel; Barten, Tommy; Grzela, Grzegorz; Rivas, Jaime Gómez

    2014-01-01

    We demonstrate that an ordered array of aluminum nanopyramids, behaving as a phased array of optical antennae, strongly modifies light absorption in thin layers of dye molecules. Photoluminescence measurements as a function of the illumination angle are performed using a time-reversed Fourier microscope. This technique enables a variable-angle plane-wave illumination of nanostructures in a microscope-based setup. Our measurements reveal an enhancement of the light conversion in certain directions of illumination, which indicate the efficient diffractive coupling between the free space radiation and the surface plasmons. Numerical simulations confirm that surface modes supported by the periodic array enhance the intensity of the pump field in the space between particles, where the dye molecules are located, yielding a directional plasmonic-mediated enhancement of the optical absorption. This combined experimental and numerical characterization of the angular dependence of light absorption in nanostructures can be beneficial for the design and optimization of devices in which the harvesting of light plays a major role. (paper)

  11. The effects of the European Working Time Directive on surgical training: the basic surgical trainee's perspective.

    LENUS (Irish Health Repository)

    Kelly, B D

    2012-01-31

    BACKGROUND: On the 1 August 2009, the implementation of European Working Time Directive became European law and was implemented in Galway University Hospital (GUH). AIMS: The aim of the study is to ascertain the opinion of the 25 surgical SHOs in GUH on the effect of the implementation of an EWTD compliant roster had on the quality of their training. METHODS: A questionnaire was circulated to all 25 surgical SHOs. RESULTS: Twenty-two (88%) SHOs report a reduction in the quality of their training. 18 (72%) report a reduction in the development of their operative skills. The SHOs believed the EWTD Rotas would encourage Irish graduates to train abroad. CONCLUSIONS: Surgical training faces a challenge with the implementation of EWTD Rotas. Major changes need to be made to the surgical training structure to train surgeons to the highest standard and to retain Irish-trained surgeons in the Irish healthcare system.

  12. Profiling of Piper betle Linn. cultivars by direct analysis in real time mass spectrometric technique.

    Science.gov (United States)

    Bajpai, Vikas; Sharma, Deepty; Kumar, Brijesh; Madhusudanan, K P

    2010-12-01

    Piper betle Linn. is a traditional plant associated with the Asian and southeast Asian cultures. Its use is also recorded in folk medicines in these regions. Several of its medicinal properties have recently been proven. Phytochemical analysis showed the presence of mainly terpenes and phenols in betel leaves. These constituents vary in the different cultivars of Piper betle. In this paper we have attempted to profile eight locally available betel cultivars using the recently developed mass spectral ionization technique of direct analysis in real time (DART). Principal component analysis has also been employed to analyze the DART MS data of these betel cultivars. The results show that the cultivars of Piper betle could be differentiated using DART MS data. Copyright © 2010 John Wiley & Sons, Ltd.

  13. Real time optimization of solar powered direct contact membrane distillation based on multivariable extremum seeking

    KAUST Repository

    Karam, Ayman M.; Laleg-Kirati, Taous-Meriem

    2015-01-01

    This paper presents a real time optimization scheme for a solar powered direct contact membrane distillation (DCMD) water desalination system. The sun and weather conditions vary and are inconsistent throughout the day. Therefore, the solar powered DCMD feed inlet temperature is never constant, which influences the distilled water flux. The problem of DCMD process optimization has not been studied enough. In this work, the response of the process under various feed inlet temperatures is investigated, which demonstrates the need for an optimal controller. To address this issue, we propose a multivariable Newton-based extremum seeking controller which optimizes the inlet feed and permeate mass flow rates as the feed inlet temperature varies. Results are presented and discussed for a realistic temperature profile.

  14. Bi-Directional Brillouin Optical Time Domain Analyzer System for Long Range Distributed Sensing.

    Science.gov (United States)

    Guo, Nan; Wang, Liang; Wang, Jie; Jin, Chao; Tam, Hwa-Yaw; Zhang, A Ping; Lu, Chao

    2016-12-16

    We propose and experimentally demonstrate a novel scheme of bi-directional Brillouin time domain analyzer (BD-BOTDA) to extend the sensing range. By deploying two pump-probe pairs at two different wavelengths, the Brillouin frequency shift (BFS) distribution over each half of the whole fiber can be obtained with the simultaneous detection of Brillouin signals in both channels. Compared to the conventional unidirectional BOTDA system of the same sensing range, the proposed BD-BOTDA scheme enables distributed sensing with a performance level comparable to the conventional one with half of the sensing range and a spatial resolution of 2 m, while maintaining the Brillouin signal-to-noise ratio (SNR) and the BFS uncertainty. Based on this technique, we have achieved distributed temperature sensing with a measurement range of 81.9 km fiber at a spatial resolution of 2 m and BFS uncertainty of ~0.44 MHz without introducing any complicated components or schemes.

  15. Surgical training and the European Working Time Directive: The role of informal workplace learning.

    Science.gov (United States)

    Giles, James A

    2010-01-01

    The introduction of European Working Time Directive, limiting doctors' working hours to 48 per week, has caused recent controversy within the profession. The Royal College of Surgeons of England in particular has been one of the loudest critics of the legislation. One of the main concerns is regarding the negative impact on training hours for those embarking on surgical careers. Simulation technology has been suggested as a method to overcome this reduction in hospital training hours, and research suggests that this is a good substitute for operative training in a theatre. However, modern educational theory emphasises the power of informal workplace learning in postgraduate education, and the essential role of experience in training future surgeons. Copyright 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  16. Action Video Games Improve Direction Discrimination of Parafoveal Translational Global Motion but Not Reaction Times.

    Science.gov (United States)

    Pavan, Andrea; Boyce, Matthew; Ghin, Filippo

    2016-10-01

    Playing action video games enhances visual motion perception. However, there is psychophysical evidence that action video games do not improve motion sensitivity for translational global moving patterns presented in fovea. This study investigates global motion perception in action video game players and compares their performance to that of non-action video game players and non-video game players. Stimuli were random dot kinematograms presented in the parafovea. Observers discriminated the motion direction of a target random dot kinematogram presented in one of the four visual quadrants. Action video game players showed lower motion coherence thresholds than the other groups. However, when the task was performed at threshold, we did not find differences between groups in terms of distributions of reaction times. These results suggest that action video games improve visual motion sensitivity in the near periphery of the visual field, rather than speed response. © The Author(s) 2016.

  17. Bi-Directional Brillouin Optical Time Domain Analyzer System for Long Range Distributed Sensing

    Science.gov (United States)

    Guo, Nan; Wang, Liang; Wang, Jie; Jin, Chao; Tam, Hwa-Yaw; Zhang, A. Ping; Lu, Chao

    2016-01-01

    We propose and experimentally demonstrate a novel scheme of bi-directional Brillouin time domain analyzer (BD-BOTDA) to extend the sensing range. By deploying two pump-probe pairs at two different wavelengths, the Brillouin frequency shift (BFS) distribution over each half of the whole fiber can be obtained with the simultaneous detection of Brillouin signals in both channels. Compared to the conventional unidirectional BOTDA system of the same sensing range, the proposed BD-BOTDA scheme enables distributed sensing with a performance level comparable to the conventional one with half of the sensing range and a spatial resolution of 2 m, while maintaining the Brillouin signal-to-noise ratio (SNR) and the BFS uncertainty. Based on this technique, we have achieved distributed temperature sensing with a measurement range of 81.9 km fiber at a spatial resolution of 2 m and BFS uncertainty of ~0.44 MHz without introducing any complicated components or schemes. PMID:27999250

  18. Exhaust gas concentration of CNG fuelled direct injection engine at MBT timing

    International Nuclear Information System (INIS)

    Hassan, M.K.; Aris, I.; Mahmod, S.; Sidek, R.

    2009-01-01

    Full text: This paper presents an experimental result of exhaust gas concentration of high compression engine fuelled with compressed natural gas (CNG) at maximum brake torque (MBT). The engine uses central direct injection (DI) technique to inject the CNG into the cylinder. The engine geometry bases on gasoline engine with 14:1 compression ratio and called CNGDI engine. The injectors are positioned within a certain degrees of spark plug location. The objective of the experiment is to study the influence and significant of MBT timing in CNGDI engine towards exhaust gases. The experimental tests were carried out using computer-controlled eddy-current dynamometer, which measures the CNGDI engine performance. At MBT region, exhaust gas concentration as such CO, HC, NO x , O 2 and CO 2 , were recorded and analyzed during the test using the Horiba analyzer. A closed loop wide band lambda sensor has been mounted at the exhaust manifold to indicate the oxygen level during the exercise. (author)

  19. Real time optimization of solar powered direct contact membrane distillation based on multivariable extremum seeking

    KAUST Repository

    Karam, Ayman M.

    2015-09-21

    This paper presents a real time optimization scheme for a solar powered direct contact membrane distillation (DCMD) water desalination system. The sun and weather conditions vary and are inconsistent throughout the day. Therefore, the solar powered DCMD feed inlet temperature is never constant, which influences the distilled water flux. The problem of DCMD process optimization has not been studied enough. In this work, the response of the process under various feed inlet temperatures is investigated, which demonstrates the need for an optimal controller. To address this issue, we propose a multivariable Newton-based extremum seeking controller which optimizes the inlet feed and permeate mass flow rates as the feed inlet temperature varies. Results are presented and discussed for a realistic temperature profile.

  20. Two-dimensional time-resolved X-ray diffraction study of directional solidification in steels

    International Nuclear Information System (INIS)

    Yonemura, Mitsuharu

    2009-01-01

    Full text: The high intensity heat source used for fusion welding creates steep thermal gradients of 100 degree C/s from 1800 degree Celsius. Further, the influence of a preferred orientation is serious for observation of a directional solidification that follows the dendrite growth along the direction toward the moving heat source. Therefore, we observed the rapid solidification of weld metal at a time resolution of 0.01∼0.1seconds by the Two-Dimensional Time-Resolved X-ray Diffraction (2DTRXRD) system for real welding. The diffraction ring was dynamically observed by 2DTRXRD during arc-passing over the irradiation area of X-ray with synchrotron energy of 18 KeV. The arc power output was 10 V - 150 A, and a scan speed of the arc was 1.0 mm/s. The temperature rise of instruments was suppressed by the water-cooled copper plate under the sample. Further, the temperature distribution of the weld metal was measured by the thermocouple and related to the diffraction patterns. Consequently, solidification and solid phase transformation of low carbon steels and stainless steels were observed during rapid cooling by 2DTRXRD. In the low-carbon steel, the microstructure is formed in the 2 step process; (i) formation of crystallites and (ii) increase of crystallinity. In the stainless steel, the irregular interface layer of σ/y in the quenched metal after solidification is expected that it is easy for dendrites to move at the lower temperature. In the carbide precipitation stainless steel, it is easy for NbC to grow on σ phase with a little under cooling. Further, a mist-like pattern, which differs from the halo-pattern, in the fusion zone gave some indication of the possibilities to observe the nucleation and the early solidification by 2DTRXRD. (author)

  1. A qualitative investigation of Foundation Year 2 doctors' views on the European Working Time Directive.

    Science.gov (United States)

    Duncan, Myanna; Haslam, Cheryl

    2015-01-01

    PURPOSE - The purpose of this paper is to examine the personal views and experiences of Foundation Year 2 doctors operating under the European Working Time Directive (EWTD). DESIGN/METHODOLOGY/APPROACH - In total, 36 Foundation Year 2 doctors from a single UK-based Deanery participated in this semistructured interview study. FINDINGS - Findings indicated that Foundation doctors typically welcomed a regulation of working hours, but reported frustration at the manner in which the Directive had been implemented. Participants reported concerns at reducing hours by removing out-of-hours working in order to meet EWTD requirements. Out-of-hours shifts were highly valued owing to their increased opportunities for autonomous clinical decision making. By contrast, day-shifts were regarded as heavily administrative in nature and were perceived as service provision. Foundation doctors discussed the unique nature of the out-of-hours working period which appeared to provide specific learning opportunities as doctors draw on time management and prioritisation skills. ORIGINALITY/VALUE - Given the challenges the EWTD presents, careful rota planning is essential. First, the authors would encourage the restructuring of day-shift work to provide a greater emphasis on hands-on skills experience in a supportive, supervised environment. Second, where possible, Foundation doctors might benefit from the opportunity to engage in some out-of-hours working, such as with multi-professional "Hospital at Night" teams. Third, the authors would encourage junior doctor involvement in rota design and planning which may increase their perceived autonomy and therefore buy-in of working practices.

  2. Transfer Entropy Estimation and Directional Coupling Change Detection in Biomedical Time Series

    Directory of Open Access Journals (Sweden)

    Lee Joon

    2012-04-01

    Full Text Available Abstract Background The detection of change in magnitude of directional coupling between two non-linear time series is a common subject of interest in the biomedical domain, including studies involving the respiratory chemoreflex system. Although transfer entropy is a useful tool in this avenue, no study to date has investigated how different transfer entropy estimation methods perform in typical biomedical applications featuring small sample size and presence of outliers. Methods With respect to detection of increased coupling strength, we compared three transfer entropy estimation techniques using both simulated time series and respiratory recordings from lambs. The following estimation methods were analyzed: fixed-binning with ranking, kernel density estimation (KDE, and the Darbellay-Vajda (D-V adaptive partitioning algorithm extended to three dimensions. In the simulated experiment, sample size was varied from 50 to 200, while coupling strength was increased. In order to introduce outliers, the heavy-tailed Laplace distribution was utilized. In the lamb experiment, the objective was to detect increased respiratory-related chemosensitivity to O2 and CO2 induced by a drug, domperidone. Specifically, the separate influence of end-tidal PO2 and PCO2 on minute ventilation (V˙E before and after administration of domperidone was analyzed. Results In the simulation, KDE detected increased coupling strength at the lowest SNR among the three methods. In the lamb experiment, D-V partitioning resulted in the statistically strongest increase in transfer entropy post-domperidone for PO2→V˙E. In addition, D-V partitioning was the only method that could detect an increase in transfer entropy for PCO2→V˙E, in agreement with experimental findings. Conclusions Transfer entropy is capable of detecting directional coupling changes in non-linear biomedical time series analysis featuring a small number of observations and presence of outliers. The results

  3. Extended causal modeling to assess Partial Directed Coherence in multiple time series with significant instantaneous interactions.

    Science.gov (United States)

    Faes, Luca; Nollo, Giandomenico

    2010-11-01

    The Partial Directed Coherence (PDC) and its generalized formulation (gPDC) are popular tools for investigating, in the frequency domain, the concept of Granger causality among multivariate (MV) time series. PDC and gPDC are formalized in terms of the coefficients of an MV autoregressive (MVAR) model which describes only the lagged effects among the time series and forsakes instantaneous effects. However, instantaneous effects are known to affect linear parametric modeling, and are likely to occur in experimental time series. In this study, we investigate the impact on the assessment of frequency domain causality of excluding instantaneous effects from the model underlying PDC evaluation. Moreover, we propose the utilization of an extended MVAR model including both instantaneous and lagged effects. This model is used to assess PDC either in accordance with the definition of Granger causality when considering only lagged effects (iPDC), or with an extended form of causality, when we consider both instantaneous and lagged effects (ePDC). The approach is first evaluated on three theoretical examples of MVAR processes, which show that the presence of instantaneous correlations may produce misleading profiles of PDC and gPDC, while ePDC and iPDC derived from the extended model provide here a correct interpretation of extended and lagged causality. It is then applied to representative examples of cardiorespiratory and EEG MV time series. They suggest that ePDC and iPDC are better interpretable than PDC and gPDC in terms of the known cardiovascular and neural physiologies.

  4. Characteristics of a direct methanol fuel cell system with the time shared fuel supplying approach

    International Nuclear Information System (INIS)

    Na, Youngseung; Kwon, Jungmin; Kim, Hyun; Cho, Hyejung; Song, Inseob

    2013-01-01

    DMFC (direct methanol fuel cell) systems usually employ two pumps for supplying the methanol solution. The conventional system configuration, however, may bring about free flow from the methanol reservoir and malfunctions in the self-priming of the pumps. When instruments such as check valves and pressure regulators are applied, they result in excessive weight and control system malfunctions. In this paper, a light and robust DMFC system is proposed. By using the time sharing approach to supply fuel with a 3-way valve, free flow does not occur because only one inlet is opened at one time which means that both the circulation flow from gas liquid separator and the fuel flow from the methanol cartridge are not allowed to be opened at same time. As a result, back flow and self-priming problems do not occur. This makes the system stable and robust due to the removal of both the check valves and the fluctuation from unstable back pressure. Stabilized system doesn't need excessive battery buffering and recycling water any more, which are responsible for the heavy system. The proposed system performs the same level of power and efficiency with the conventional system. Adaptability is also carried out in various environmental temperature conditions. - Highlights: ►A light and robust DMFC system is proposed. ► The circulation pump is able to self-prime by itself after long term storage. ► The time sharing approach to supply fuel enables to control the methanol concentration precisely. ► The methanol concentration is controlled without free flow and the back flow from the fuel feeding pump. ► The excessive buffer of the batteries and the recycling water level are reduced

  5. Sample introduction systems for reversed phase LC-ICP-MS of selenium using large amounts of methanol - comparison of systems based on membrane desolvation, a spray chamber and direct injection

    DEFF Research Database (Denmark)

    Bendahl, L.; Gammelgaard, Bente

    2005-01-01

    nebuliser (MCN) in combination with a membrane desolvator ( MD), a MCN in combination with a cyclonic spray chamber ( CS) and a direct injection nebuliser ( DIN), respectively. Thirteen selenium standards diluted in 50% methanol were introduced in each system at a flow rate of 50 mu l min(-1). Except...

  6. A centrifugal direct recombinase polymerase amplification (direct-RPA) microdevice for multiplex and real-time identification of food poisoning bacteria.

    Science.gov (United States)

    Choi, Goro; Jung, Jae Hwan; Park, Byung Hyun; Oh, Seung Jun; Seo, Ji Hyun; Choi, Jong Seob; Kim, Do Hyun; Seo, Tae Seok

    2016-06-21

    In this study, we developed a centrifugal direct recombinase polymerase amplification (direct-RPA) microdevice for multiplex and real-time identification of food poisoning bacteria contaminated milk samples. The microdevice was designed to contain identical triplicate functional units and each unit has four reaction chambers, thereby making it possible to perform twelve direct-RPA reactions simultaneously. The integrated microdevice consisted of two layers: RPA reagents were injected in the top layer, while spiked milk samples with food poisoning bacteria were loaded into sample reservoirs in the bottom layer. For multiplex bacterial detection, the target gene-specific primers and probes were dried in each reaction chamber. The introduced samples and reagents could be equally aliquoted and dispensed into each reaction chamber by centrifugal force, and then the multiplex direct-RPA reaction was executed. The target genes of bacteria spiked in milk could be amplified at 39 °C without a DNA extraction step by using the direct-RPA cocktails, which were a combination of a direct PCR buffer and RPA enzymes. As the target gene amplification proceeded, the increased fluorescence signals coming from the reaction chambers were recorded in real-time at an interval of 2 min. The entire process, including the sample distribution, the direct-RPA reaction, and the real-time analysis, was accomplished with a custom-made portable genetic analyzer and a miniaturized optical detector. Monoplex, duplex, and triplex food poisoning bacteria (Salmonella enterica, Escherichia coli O157:H7, and Vibrio parahaemolyticus) detection was successfully performed with a detection sensitivity of 4 cells per 3.2 μL of milk samples within 30 min. By implementing the direct-PRA on the miniaturized centrifugal microsystem, the on-site food poisoning bacteria analysis would be feasible with high speed, sensitivity, and multiplicity.

  7. Monitoring transcranial direct current stimulation induced changes in cortical excitability during the serial reaction time task.

    Science.gov (United States)

    Ambrus, Géza Gergely; Chaieb, Leila; Stilling, Roman; Rothkegel, Holger; Antal, Andrea; Paulus, Walter

    2016-03-11

    The measurement of the motor evoked potential (MEP) amplitudes using single pulse transcranial magnetic stimulation (TMS) is a common method to observe changes in motor cortical excitability. The level of cortical excitability has been shown to change during motor learning. Conversely, motor learning can be improved by using anodal transcranial direct current stimulation (tDCS). In the present study, we aimed to monitor cortical excitability changes during an implicit motor learning paradigm, a version of the serial reaction time task (SRTT). Responses from the first dorsal interosseous (FDI) and forearm flexor (FLEX) muscles were recorded before, during and after the performance of the SRTT. Online measurements were combined with anodal, cathodal or sham tDCS for the duration of the SRTT. Negative correlations between the amplitude of online FDI MEPs and SRTT reaction times (RTs) were observed across the learning blocks in the cathodal condition (higher average MEP amplitudes associated with lower RTs) but no significant differences in the anodal and sham conditions. tDCS did not have an impact on SRTT performance, as would be predicted based on previous studies. The offline before-after SRTT MEP amplitudes showed an increase after anodal and a tendency to decrease after cathodal stimulation, but these changes were not significant. The combination of different interventions during tDCS might result in reduced efficacy of the stimulation that in future studies need further attention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  8. Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Zhu, Hongbin; Wang, Chunyan; Qi, Yao; Song, Fengrui; Liu, Zhiqiang; Liu, Shuying

    2012-11-08

    This study presents a novel and rapid method to identify chemical markers for the quality control of Radix Aconiti Preparata, a world widely used traditional herbal medicine. In the method, the samples with a fast extraction procedure were analyzed using direct analysis in real time mass spectrometry (DART MS) combined with multivariate data analysis. At present, the quality assessment approach of Radix Aconiti Preparata was based on the two processing methods recorded in Chinese Pharmacopoeia for the purpose of reducing the toxicity of Radix Aconiti and ensuring its clinical therapeutic efficacy. In order to ensure the safety and effectivity in clinical use, the processing degree of Radix Aconiti should be well controlled and assessed. In the paper, hierarchical cluster analysis and principal component analysis were performed to evaluate the DART MS data of Radix Aconiti Preparata samples in different processing times. The results showed that the well processed Radix Aconiti Preparata, unqualified processed and the raw Radix Aconiti could be clustered reasonably corresponding to their constituents. The loading plot shows that the main chemical markers having the most influence on the discrimination amongst the qualified and unqualified samples were mainly some monoester diterpenoid aconitines and diester diterpenoid aconitines, i.e. benzoylmesaconine, hypaconitine, mesaconitine, neoline, benzoylhypaconine, benzoylaconine, fuziline, aconitine and 10-OH-mesaconitine. The established DART MS approach in combination with multivariate data analysis provides a very flexible and reliable method for quality assessment of toxic herbal medicine. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. Analysis of writing inks on paper using direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Jones, Roger W; McClelland, John F

    2013-09-10

    Ink analysis is central to questioned document examination. We applied direct analysis in real time mass spectrometry (DART MS) to ballpoint, gel, and fluid writing ink analysis. DART MS acquires the mass spectrum of an ink while it is still on a document without altering the appearance of the document. Spectra were acquired from ink on a variety of papers, and the spectrum of the blank paper could be subtracted out to produce a cleanly isolated ink spectrum in most cases. Only certain heavy or heavily processed papers interfered. The time since an ink is written on paper has a large effect on its spectrum. DART spectra change radically during the first few months after an ink is written as the more volatile components evaporate, but the spectra stabilize after that. A library-search study involving 166 well-aged inks assessed the ability to identify inks from their DART spectra. The aggregate success rate was 92%. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  10. Time-variant partial directed coherence in analysis of the cardiovascular system. A methodological study

    International Nuclear Information System (INIS)

    Milde, T; Schwab, K; Walther, M; Eiselt, M; Witte, H; Schelenz, C; Voss, A

    2011-01-01

    Time-variant partial directed coherence (tvPDC) is used for the first time in a multivariate analysis of heart rate variability (HRV), respiratory movements (RMs) and (systolic) arterial blood pressure. It is shown that respiration-related HRV components which also occur at other frequencies besides the RM frequency (= respiratory sinus arrhythmia, RSA) can be identified. These additional components are known to be an effect of the 'half-the-mean-heart-rate-dilemma' ('cardiac aliasing' CA). These CA components may contaminate the entire frequency range of HRV and can lead to misinterpretation of the RSA analysis. TvPDC analysis of simulated and clinical data (full-term neonates and sedated patients) reveals these contamination effects and, in addition, the respiration-related CA components can be separated from the RSA component and the Traube–Hering–Mayer wave. It can be concluded that tvPDC can be beneficially applied to avoid misinterpretations in HRV analyses as well as to quantify partial correlative interaction properties between RM and RSA

  11. Divergence times in Caenorhabditis and Drosophila inferred from direct estimates of the neutral mutation rate.

    Science.gov (United States)

    Cutter, Asher D

    2008-04-01

    Accurate inference of the dates of common ancestry among species forms a central problem in understanding the evolutionary history of organisms. Molecular estimates of divergence time rely on the molecular evolutionary prediction that neutral mutations and substitutions occur at the same constant rate in genomes of related species. This underlies the notion of a molecular clock. Most implementations of this idea depend on paleontological calibration to infer dates of common ancestry, but taxa with poor fossil records must rely on external, potentially inappropriate, calibration with distantly related species. The classic biological models Caenorhabditis and Drosophila are examples of such problem taxa. Here, I illustrate internal calibration in these groups with direct estimates of the mutation rate from contemporary populations that are corrected for interfering effects of selection on the assumption of neutrality of substitutions. Divergence times are inferred among 6 species each of Caenorhabditis and Drosophila, based on thousands of orthologous groups of genes. I propose that the 2 closest known species of Caenorhabditis shared a common ancestor <24 MYA (Caenorhabditis briggsae and Caenorhabditis sp. 5) and that Caenorhabditis elegans diverged from its closest known relatives <30 MYA, assuming that these species pass through at least 6 generations per year; these estimates are much more recent than reported previously with molecular clock calibrations from non-nematode phyla. Dates inferred for the common ancestor of Drosophila melanogaster and Drosophila simulans are roughly concordant with previous studies. These revised dates have important implications for rates of genome evolution and the origin of self-fertilization in Caenorhabditis.

  12. Separating Direct and Indirect Turbofan Engine Combustion Noise While Estimating Post-Combustion (Post-Flame) Residence Time Using the Correlation Function

    Science.gov (United States)

    Miles, Jeffrey Hilton

    2011-01-01

    A previous investigation on the presence of direct and indirect combustion noise for a full-scale turbofan engine using a far-field microphone at 130 is extended by also examining signals obtained at two additional downstream directions using far-field microphones at 110 deg and 160 deg. A generalized cross-correlation function technique is used to study the change in propagation time to the far field of the combined direct and indirect combustion noise signal as a sequence of low-pass filters are applied. The filtering procedure used produces no phase distortion. As the low-pass filter frequency is decreased, the travel time increases because the relative amount of direct combustion noise is reduced. The indirect combustion noise signal travels more slowly because in the combustor entropy fluctuations move with the flow velocity, which is slow compared to the local speed of sound. The indirect combustion noise signal travels at acoustic velocities after reaching the turbine and being converted into an acoustic signal. The direct combustion noise is always propagating at acoustic velocities. The results show that the estimated indirect combustion noise time delay values (post-combustion residence times) measured at each angle are fairly consistent with one another for a relevant range of operating conditions and demonstrate source separation of a mixture of direct and indirect combustion noise. The results may lead to a better idea about the acoustics in the combustor and may help develop and validate improved reduced-order physics-based methods for predicting turbofan engine core noise.

  13. Investigating the Relationship Between Self-Directed Learning Readiness and Time Management Skills in Turkish Undergraduate Nursing Students.

    Science.gov (United States)

    Ertuğ, Nurcan; Faydali, Saide

    The aims of this study were to determine self-directed learning and time management skills of undergraduate nursing students and to investigate the relationship between the concepts. The use of self-directed learning has increased as an educational strategy in recent years. This descriptive and correlational study was conducted with 383 undergraduate nursing students in Turkey. Data were collected using a sociodemographic questionnaire, the Self-Directed Learning Readiness Scale, and Time Management Questionnaire. Mean scores were as follows: self-directed learning readiness, 159.12 (SD = 20.8); time management, 87.75 (SD = 12.1). A moderate positive correlation was found between self-directed learning readiness and time management values. Time management scores were 78.42 when self-directed learning readiness was ≤149 and 90.82 when self-directed learning readiness was ≥ 150, with a statistically significant difference (p = .000). Level of self-directed learning and academic achievement were higher in students who managed their time well.

  14. Time-dependent changes in extra-domain A-fibronectin concentration and relative amounts of fibronectin-fibrin complexes in plasma of patients with peripheral arterial disease after endovascular revascularisation.

    Science.gov (United States)

    Pupek, Małgorzata; Krzyżanowska-Gołąb, Dorota; Kotschy, Daniel; Witkiewicz, Wojciech; Kwiatkowska, Wiesława; Kotschy, Maria; Kątnik-Prastowska, Iwona

    2018-03-13

    Fibronectin (FN) may be involved in time- and stage-dependent and inter-related controlled processes of inflammation, coagulation, and wound healing accompanying peripheral arterial disease (PAD). In the present study, FN and FN-containing extra-domain A (EDA-FN), macromolecular FN-fibrin complexes, and FN monomer were analysed in the plasma of 142 PAD patients, including 37 patients with restenosis, for 37 months after revascularisation. FN concentration increased significantly in the plasma of PAD patients within 7 to 12 months after revascularisation, whereas the high concentration of EDA-FN was maintained up to 24 months, significantly higher in the group 7 to 12 months after revascularisation with recurrence of stenosis and lower in the PAD groups 1 to 3 months and 4 to 6 months after revascularisation with comorbid diabetes and ulceration, respectively. The relative amounts of FN-fibrin complexes up to 1600 kDa and FN monomer were significantly higher, within intervals of 4 to 24 months and 4 to 6 months after revascularisation, respectively. Moreover, the relative amounts of 750 to 1600 kDa FN-fibrin complexes within 13 to 24 months after revascularisation were higher in comparison with those in the group without restenosis. In conclusion, high levels of EDA-FN and FN-fibrin complexes could have potential diagnostic value in the management of PAD patients after revascularisation, predicting restenosis risk. © 2018 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  15. Current neurosurgical trainees' perception of the European Working Time Directive and shift work.

    Science.gov (United States)

    Tait, M J; Fellows, G A; Pushpananthan, S; Sergides, Y; Papadopoulos, M C; Bell, B A

    2008-02-01

    The introduction of the shift system in response to the European Working Time Directive has had an enormous impact on the running of neurosurgical units in the UK. This study seeks to establish what provisions are currently in place for out of hours cover and what has been the effect of the introduction of shifts in three main areas: patient safety, training and 'work/life balance'. The on-call registrar at each UK neurosurgical unit was contacted by telephone. Data regarding current emergency provision were sought. Registrars who had worked both on-calls and the shift system during their career as a neurosurgical registrar were asked to make a comparison. Data were collected from all 33 UK units. Twenty-two still use a traditional 24-h on-call system. Twenty-one on-call rotas were classed as non-resident although 12/21 of those officially on non-resident rotas were in fact resident whilst on call. Twenty-two registrars had worked both systems as a neurosurgical registrar. Twenty-one (95.45%) felt that traditional on-calls gave better clinical exposure. Twenty-one (95.45%) felt that on-calls allowed the provision of better patient care. Nineteen (86.36%) felt that on-calls were safer. Thirteen (59.09%) reported that they were more tired when doing shift work than on-calls. Fourteen (63.63%) found that the on-call system gives more useful spare time and more time to deal with family commitments. Current neurosurgery registrars feel the shift system is less safe, harmful to training and worse in terms of work/life balance. More than one-third of units are claiming to have non-resident on-call systems in order to appear compliant with EWTD when registrars are in fact resident.

  16. Experience of plastic surgery registrars in a European Working Time Directive compliant rota.

    Science.gov (United States)

    de Blacam, Catherine; Tierney, Sean; Shelley, Odhran

    2017-08-01

    Surgical training requires exposure to clinical decision-making and operative experience in a supervised environment. It is recognised that learning ability is compromised when fatigued. The European Working Time Directive requires a decrease in working hours, but compliance reduces trainees' clinical exposure, which has profound implications for plastic surgery training. The aim of this study was to evaluate plastic surgery registrars' experience of an EWTD-compliant rota, and to examine its impact on patient care, education, and logbook activity. An electronic survey was distributed to plastic surgery registrars in a university teaching hospital. Registrars were asked to rate 31 items on a five-point Likert scale, including statements on patient care, clinical and operative duties, training, and quality-of-life. Interquartile deviations explored consensus among responses. Operative caseload was objectively evaluated using eLogbook data to compare activity at equal time points before and after implementation of the EWTD rota. Highest levels of consensus among respondents were found in positive statements addressing alertness and preparation for theatre, as well as time to read and study for exams. Registrars agreed that EWTD compliance improved their quality-of-life. However, it was felt that continuity of patient care was compromised by work hours restriction. Registrars were concerned about their operative experience. eLogbook data confirmed a fall-off in mean caseload of 31.8% compared to activity prior to EWTD rota implementation. While EWTD compliant rotas promote trainee quality-of-life and satisfaction with training, attention needs to be paid to optimising operative opportunities.

  17. Homicides with direct and indirect links to the night-time economy.

    Science.gov (United States)

    Tomsen, Stephen

    2018-06-11

    Alcohol use and homicide are a wide community concern with particular interest in understanding and preventing attacks (e.g. 'one punch' male on male attacks) in commercial nightlife settings with high levels of collective drinking. There is insufficient knowledge of the long-term patterns in this violence or the relationship between public drinking and flow on violence in other social settings. Alcohol-related homicides were those in which alcohol consumption was a contributing factor. Those also linked to purchase or consumption in locations where alcohol is sold after dark were classified as night-time economy related. The study comprised a first-hand analysis of files in the archive of the Australian National Homicide Monitoring Program in 2 years with a decade gap (1998/1999-2007/2008), and it classified 73 of all 238 alcohol-related incidents by direct or indirect relation to public nightlife settings. Related homicides in these years were not highly concentrated in developed night-time economies, but more spread outside major nightlife zones. Indirectly related killings were even more dispersed and included more women victims killed in domestic settings. There is a consistent though dispersed relationship between heavy public drinking at night and homicide. Concerns about homicide and night-time drinking leisure with mostly male victims attacked in well-known areas of busy city nightlife, must also consider the broader gendered patterns of 'flow on' nightlife-related incidents, including fatal semi-private and domestic violence that is indirectly but importantly related to drinking and alcohol purchase in public commercial nightlife. © 2018 Australasian Professional Society on Alcohol and other Drugs.

  18. Circadian clock gene LATE ELONGATED HYPOCOTYL directly regulates the timing of floral scent emission in Petunia.

    Science.gov (United States)

    Fenske, Myles P; Hewett Hazelton, Kristen D; Hempton, Andrew K; Shim, Jae Sung; Yamamoto, Breanne M; Riffell, Jeffrey A; Imaizumi, Takato

    2015-08-04

    Flowers present a complex display of signals to attract pollinators, including the emission of floral volatiles. Volatile emission is highly regulated, and many species restrict emissions to specific times of the day. This rhythmic emission of scent is regulated by the circadian clock; however, the mechanisms have remained unknown. In Petunia hybrida, volatile emissions are dominated by products of the floral volatile benzenoid/phenylpropanoid (FVBP) metabolic pathway. Here we demonstrate that the circadian clock gene P. hybrida LATE ELONGATED HYPOCOTYL (LHY; PhLHY) regulates the daily expression patterns of the FVBP pathway genes and floral volatile production. PhLHY expression peaks in the morning, antiphasic to the expression of P. hybrida GIGANTEA (PhGI), the master scent regulator ODORANT1 (ODO1), and many other evening-expressed FVBP genes. Overexpression phenotypes of PhLHY in Arabidopsis caused an arrhythmic clock phenotype, which resembles those of LHY overexpressors. In Petunia, constitutive expression of PhLHY depressed the expression levels of PhGI, ODO1, evening-expressed FVBP pathway genes, and FVBP emission in flowers. Additionally, in the Petunia lines in which PhLHY expression was reduced, the timing of peak expression of PhGI, ODO1, and the FVBP pathway genes advanced to the morning. Moreover, PhLHY protein binds to cis-regulatory elements called evening elements that exist in promoters of ODO1 and other FVBP genes. Thus, our results imply that PhLHY directly sets the timing of floral volatile emission by restricting the expression of ODO1 and other FVBP genes to the evening in Petunia.

  19. CURRENT DIRECTION, cloud amount/frequency and other data from unknown platforms in the NW Pacific from 1981-08-07 to 1983-02-23 (NODC Accession 8400332)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Format and other information for these data may only be available in analog form at this time. Please contact Services.NODC@noaa.gov for additional information.

  20. Analysis of Silicones Released from Household Items and Baby Articles by Direct Analysis in Real Time-Mass Spectrometry

    Science.gov (United States)

    Gross, Jürgen H.

    2015-03-01

    Direct analysis in real time-mass spectrometry (DART-MS) enables screening of articles of daily use made of polydimethylsiloxanes (PDMS), commonly known as silicone rubber, to assess their tendency to release low molecular weight silicone oligomers. DART-MS analyses were performed on a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Flexible silicone baking molds, a watch band, and a dough scraper, as baby articles different brands of pacifiers, nipples, and a teething ring have been examined. While somewhat arbitrarily chosen, the set can be regarded as representative of household items, baby articles, and other objects made of silicone rubber. For comparison, two brands of silicone septa and as blanks a glass slide and a latex pacifier were included. Differences between the objects were mainly observed in terms of molecular weight distribution and occasional release of other compounds in addition to PDMS. Other than that, all objects made of silicone rubber released significant amounts of PDMS during DART analysis. To provide a coarse quantification, a calibration based on silicone oil was established, which delivered PDMS losses from 20 μg to >100 μg during the 16-s period per measurement. Also, the extraction of baking molds in rapeseed oil demonstrated a PDMS release at the level of 1 μg mg-1. These findings indicate a potential health hazard from frequent or long-term use of such items. This work does not intend to blame certain brands of such articles. Nonetheless, a higher level of awareness of this source of daily silicone intake is suggested.

  1. Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Hongbin; Wang Chunyan; Qi Yao [Changchun Center of Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Song Fengrui, E-mail: songfr@ciac.jl.cn [Changchun Center of Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Liu Zhiqiang; Liu Shuying [Changchun Center of Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)

    2012-11-08

    Highlights: Black-Right-Pointing-Pointer DART MS combined with PCA and HCA was used to rapidly identify markers of Radix Aconiti. Black-Right-Pointing-Pointer The DART MS behavior of six aconitine-type alkaloids was investigated. Black-Right-Pointing-Pointer Chemical markers were recognized between the qualified and unqualified samples. Black-Right-Pointing-Pointer DART MS was shown to be an effective tool for quality control of Radix Aconiti Preparata. - Abstract: This study presents a novel and rapid method to identify chemical markers for the quality control of Radix Aconiti Preparata, a world widely used traditional herbal medicine. In the method, the samples with a fast extraction procedure were analyzed using direct analysis in real time mass spectrometry (DART MS) combined with multivariate data analysis. At present, the quality assessment approach of Radix Aconiti Preparata was based on the two processing methods recorded in Chinese Pharmacopoeia for the purpose of reducing the toxicity of Radix Aconiti and ensuring its clinical therapeutic efficacy. In order to ensure the safety and effectivity in clinical use, the processing degree of Radix Aconiti should be well controlled and assessed. In the paper, hierarchical cluster analysis and principal component analysis were performed to evaluate the DART MS data of Radix Aconiti Preparata samples in different processing times. The results showed that the well processed Radix Aconiti Preparata, unqualified processed and the raw Radix Aconiti could be clustered reasonably corresponding to their constituents. The loading plot shows that the main chemical markers having the most influence on the discrimination amongst the qualified and unqualified samples were mainly some monoester diterpenoid aconitines and diester diterpenoid aconitines, i.e. benzoylmesaconine, hypaconitine, mesaconitine, neoline, benzoylhypaconine, benzoylaconine, fuziline, aconitine and 10-OH-mesaconitine. The established DART MS approach in

  2. Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry

    International Nuclear Information System (INIS)

    Zhu Hongbin; Wang Chunyan; Qi Yao; Song Fengrui; Liu Zhiqiang; Liu Shuying

    2012-01-01

    Highlights: ► DART MS combined with PCA and HCA was used to rapidly identify markers of Radix Aconiti. ► The DART MS behavior of six aconitine-type alkaloids was investigated. ► Chemical markers were recognized between the qualified and unqualified samples. ► DART MS was shown to be an effective tool for quality control of Radix Aconiti Preparata. - Abstract: This study presents a novel and rapid method to identify chemical markers for the quality control of Radix Aconiti Preparata, a world widely used traditional herbal medicine. In the method, the samples with a fast extraction procedure were analyzed using direct analysis in real time mass spectrometry (DART MS) combined with multivariate data analysis. At present, the quality assessment approach of Radix Aconiti Preparata was based on the two processing methods recorded in Chinese Pharmacopoeia for the purpose of reducing the toxicity of Radix Aconiti and ensuring its clinical therapeutic efficacy. In order to ensure the safety and effectivity in clinical use, the processing degree of Radix Aconiti should be well controlled and assessed. In the paper, hierarchical cluster analysis and principal component analysis were performed to evaluate the DART MS data of Radix Aconiti Preparata samples in different processing times. The results showed that the well processed Radix Aconiti Preparata, unqualified processed and the raw Radix Aconiti could be clustered reasonably corresponding to their constituents. The loading plot shows that the main chemical markers having the most influence on the discrimination amongst the qualified and unqualified samples were mainly some monoester diterpenoid aconitines and diester diterpenoid aconitines, i.e. benzoylmesaconine, hypaconitine, mesaconitine, neoline, benzoylhypaconine, benzoylaconine, fuziline, aconitine and 10-OH-mesaconitine. The established DART MS approach in combination with multivariate data analysis provides a very flexible and reliable method for quality

  3. Modulation of Total Sleep Time by Transcranial Direct Current Stimulation (tDCS).

    Science.gov (United States)

    Frase, Lukas; Piosczyk, Hannah; Zittel, Sulamith; Jahn, Friederike; Selhausen, Peter; Krone, Lukas; Feige, Bernd; Mainberger, Florian; Maier, Jonathan G; Kuhn, Marion; Klöppel, Stefan; Normann, Claus; Sterr, Annette; Spiegelhalder, Kai; Riemann, Dieter; Nitsche, Michael A; Nissen, Christoph

    2016-09-01

    Arousal and sleep are fundamental physiological processes, and their modulation is of high clinical significance. This study tested the hypothesis that total sleep time (TST) in humans can be modulated by the non-invasive brain stimulation technique transcranial direct current stimulation (tDCS) targeting a 'top-down' cortico-thalamic pathway of sleep-wake regulation. Nineteen healthy participants underwent a within-subject, repeated-measures protocol across five nights in the sleep laboratory with polysomnographic monitoring (adaptation, baseline, three experimental nights). tDCS was delivered via bi-frontal target electrodes and bi-parietal return electrodes before sleep (anodal 'activation', cathodal 'deactivation', and sham stimulation). Bi-frontal anodal stimulation significantly decreased TST, compared with cathodal and sham stimulation. This effect was location specific. Bi-frontal cathodal stimulation did not significantly increase TST, potentially due to ceiling effects in good sleepers. Exploratory resting-state EEG analyses before and after the tDCS protocols were consistent with the notion of increased cortical arousal after anodal stimulation and decreased cortical arousal after cathodal stimulation. The study provides proof-of-concept that TST can be decreased by non-invasive bi-frontal anodal tDCS in healthy humans. Further elucidating the 'top-down' pathway of sleep-wake regulation is expected to increase knowledge on the fundamentals of sleep-wake regulation and to contribute to the development of novel treatments for clinical conditions of disturbed arousal and sleep.

  4. Direct analysis in real time-Mass spectrometry (DART-MS) in forensic and security applications.

    Science.gov (United States)

    Pavlovich, Matthew J; Musselman, Brian; Hall, Adam B

    2018-03-01

    Over the last decade, direct analysis in real time (DART) has emerged as a viable method for fast, easy, and reliable "ambient ionization" for forensic analysis. The ability of DART to generate ions from chemicals that might be present at the scene of a criminal activity, whether they are in the gas, liquid, or solid phase, with limited sample preparation has made the technology a useful analytical tool in numerous forensic applications. This review paper summarizes many of those applications, ranging from the analysis of trace evidence to security applications, with a focus on providing the forensic scientist with a resource for developing their own applications. The most common uses for DART in forensics are in studying seized drugs, drugs of abuse and their metabolites, bulk and detonated explosives, toxic chemicals, chemical warfare agents, inks and dyes, and commercial plant and animal products that have been adulterated for economic gain. This review is meant to complement recent reviews that have described the fundamentals of the ionization mechanism and the general use of DART. We describe a wide range of forensic applications beyond the field of analyzing drugs of abuse, which dominates the literature, including common experimental and data analysis methods. © 2016 Wiley Periodicals, Inc. Mass Spec Rev 37:171-187, 2018. © 2016 Wiley Periodicals, Inc.

  5. Burnout syndrome during residency in internal medicine and pediatrics in a country without working time directive.

    Science.gov (United States)

    Aksoy, Duygu Yazgan; Durusu Tanriover, Mine; Unal, Sule; Dizdar, Omer; Kalyoncu, Umut; Karakaya, Jale; Unal, Serhat; Kale, Gulsev

    2014-01-01

    The purpose of this paper is to demonstrate burnout syndrome among internal medicine and pediatrics residents in a country that does not have the working time directive (WTD) and also to determine the risk factors and consequent impact on efficient functioning in clinical areas. A 57-item questionnaire was given to internal medicine and pediatrics residents. Responses from 22 pediatrics and 33 internal medicine residents were evaluated. Demographic findings, burnout scores, having hobbies, social activities and reading books unrelated to medicine were similar between the two groups. Six pediatrics residents (27.3 per cent) and 11 (33.3 per cent) internal medicine residents met the criteria for clinically significant burnout. Personal accomplishment scores and reading books unrelated to medicine were found to be related to burnout. Burnout is a syndrome characterized by depersonalization, emotional exhaustion and a low sense of personal accomplishment. It is important to document burnout in countries where WTDs are not implemented. Further studies might demonstrate burnout's effect on patient safety, service quality and physician's performance.

  6. European Working Time Directive and the use of simulators and models in Irish orthopaedics.

    LENUS (Irish Health Repository)

    Egan, C

    2011-09-07

    OBJECTIVE: To report on the perceptions of a group of orthopaedic trainees and trainers on perceived effects of the proposed introduction of European Working Time Directive (EWTD) restrictions into Ireland and on the use of simulators in training orthopaedic skills. METHODS: A structured questionnaire was developed to evaluate the opinions of a group of orthopaedic surgeons and trainees at the annual national orthopaedic conference. RESULTS: There were 44 participants [12 consultants, 32 trainees (15 specialist registrars, 8 registrars, 9 senior house officers)]. Seventy-five percent of participants felt that both the quality of patient care and training would be negatively affected. A higher proportion of consultants than trainees felt that quality of life would be affected. A high proportion of participants (81.8%) had used a simulator or model to learn a surgical skill and 100% would consider using them again. CONCLUSIONS: While we wait for the full introduction of the EWTD hours the perception is that both quality of patient care and training will be affected. Models and simulators are well perceived as a method of training.

  7. European Working Time Directive and the use of simulators and models in Irish orthopaedics.

    Science.gov (United States)

    Egan, C; Elliott, R; Fleming, P

    2012-03-01

    To report on the perceptions of a group of orthopaedic trainees and trainers on perceived effects of the proposed introduction of European Working Time Directive (EWTD) restrictions into Ireland and on the use of simulators in training orthopaedic skills. A structured questionnaire was developed to evaluate the opinions of a group of orthopaedic surgeons and trainees at the annual national orthopaedic conference. There were 44 participants [12 consultants, 32 trainees (15 specialist registrars, 8 registrars, 9 senior house officers)]. Seventy-five percent of participants felt that both the quality of patient care and training would be negatively affected. A higher proportion of consultants than trainees felt that quality of life would be affected. A high proportion of participants (81.8%) had used a simulator or model to learn a surgical skill and 100% would consider using them again. While we wait for the full introduction of the EWTD hours the perception is that both quality of patient care and training will be affected. Models and simulators are well perceived as a method of training.

  8. Direct Analysis in Real Time Mass Spectrometry for Characterization of Large Saccharides.

    Science.gov (United States)

    Ma, Huiying; Jiang, Qing; Dai, Diya; Li, Hongli; Bi, Wentao; Da Yong Chen, David

    2018-03-06

    Polysaccharide characterization posts the most difficult challenge to available analytical technologies compared to other types of biomolecules. Plant polysaccharides are reported to have numerous medicinal values, but their effect can be different based on the types of plants, and even regions of productions and conditions of cultivation. However, the molecular basis of the differences of these polysaccharides is largely unknown. In this study, direct analysis in real time mass spectrometry (DART-MS) was used to generate polysaccharide fingerprints. Large saccharides can break down into characteristic small fragments in the DART source via pyrolysis, and the products are then detected by high resolution MS. Temperature was shown to be a crucial parameter for the decomposition of large polysaccharide. The general behavior of carbohydrates in DART-MS was also studied through the investigation of a number of mono- and oligosaccharide standards. The chemical formula and putative ionic forms of the fragments were proposed based on accurate mass with less than 10 ppm mass errors. Multivariate data analysis shows the clear differentiation of different plant species. Intensities of marker ions compared among samples also showed obvious differences. The combination of DART-MS analysis and mechanochemical extraction method used in this work demonstrates a simple, fast, and high throughput analytical protocol for the efficient evaluation of molecular features in plant polysaccharides.

  9. On a random area variable arising in discrete-time queues and compact directed percolation

    International Nuclear Information System (INIS)

    Kearney, Michael J

    2004-01-01

    A well-known discrete-time, single-server queueing system with mean arrival rate λ and mean departure rate μ is considered from the perspective of the area, A, swept out by the queue occupation process during a busy period. We determine the exact form of the tail of the distribution, Pr(A > x); in particular, we show that Pr(A > x) ∼ Cx -1/4 exp(-Dx 1/2 ) for all ρ ≠ 1, where ρ ≡ λ/μ, and expressions for C and D are given. For the critical case ρ = 1 we show that Pr(A > x) ∼ C'x -1/3 , with C' also given. A simple mapping, used in the derivation, establishes a connection with compact directed percolation on a square lattice. As a corollary, therefore, we are also able to specify the large-area asymptotic behaviour of this model at all points in the phase diagram. This extends previous scaling results, which are only valid close to the percolation threshold

  10. Direct real-time neural evidence for task-set inertia.

    Science.gov (United States)

    Evans, Lisa H; Herron, Jane E; Wilding, Edward L

    2015-03-01

    One influential explanation for the costs incurred when switching between tasks is that they reflect interference arising from completing the previous task-known as task-set inertia. We report a novel approach for assessing task-set inertia in a memory experiment using event-related potentials (ERPs). After a study phase, participants completed a test block in which they switched between a memory task (retrieving information from the study phase) and a perceptual task. These tasks alternated every two trials. An ERP index of the retrieval of study information was evident in the memory task. It was also present on the first trial of the perceptual task but was markedly attenuated on the second. Moreover, this task-irrelevant ERP activity was positively correlated with a behavioral cost associated with switching between tasks. This real-time measure of neural activity thus provides direct evidence of task-set inertia, its duration, and the functional role it plays in switch costs. © The Author(s) 2015.

  11. A direct solution procedure for calculating time-varying stresses in structural systems by the principles of variational calculus

    International Nuclear Information System (INIS)

    Stefanou, G.D.

    1975-01-01

    The calculation of time-dependent stresses in structural systems operating at elevated temperatures with temperature gradients is discussed. The proposed method described in this report is of a direct formulation technique and

  12. Experimentally achieving borehole antenna radar directivity in the time domain in the presence of strong mutual coupling

    CSIR Research Space (South Africa)

    Vogt, D

    2008-06-01

    Full Text Available published borehole radar antennas have achieved directivity by post processing data received in the frequency domain, or by constructing an aperture antenna, where borehole dimensions allowed this. In this paper, a time-domain technique is investigated...

  13. Reply to 'Comment on 'Secure direct communication with a quantum one-time-pad''

    International Nuclear Information System (INIS)

    Deng Fuguo; Long Guilu

    2005-01-01

    We reply to the preceding comment which focused on whether there exists a quantum privacy amplification technique for purifying the unknown single-photon states transmitted. In this Reply, we will show that quantum privacy amplification is principally possible, and a specific scheme for direct communication protocol based on single photons has been constructed and will be published elsewhere. Then the secure direct quantum communication is secure against the attack strategy in the preceding comment by using quantum privacy amplification directly

  14. Control of Strobilurin Fungicides in Wheat Using Direct Analysis in Real Time Accurate Time-of-Flight and Desorption Electrospray Ionization Linear Ion Trap Mass Spectrometry

    NARCIS (Netherlands)

    Schurek, J.; Vaclavik, L.; Hooijerink, H.; Lacina, O.; Poustka, J.; Sharman, M.; Caldow, M.; Nielen, M.W.F.; Hajslova, J.

    2008-01-01

    Ambient mass spectrometry has been used for the analysis of strobilurin residues in wheat. The use of this novel, challenging technique, employing a direct analysis in a real time (DART) ion-source coupled with a time-of-flight mass spectrometer (TOF MS) and a desorption electrospray ionization

  15. Cluster Analysis of Time-Dependent Crystallographic Data: Direct Identification of Time-Independent Structural Intermediates

    Science.gov (United States)

    Kostov, Konstantin S.; Moffat, Keith

    2011-01-01

    The initial output of a time-resolved macromolecular crystallography experiment is a time-dependent series of difference electron density maps that displays the time-dependent changes in underlying structure as a reaction progresses. The goal is to interpret such data in terms of a small number of crystallographically refinable, time-independent structures, each associated with a reaction intermediate; to establish the pathways and rate coefficients by which these intermediates interconvert; and thereby to elucidate a chemical kinetic mechanism. One strategy toward achieving this goal is to use cluster analysis, a statistical method that groups objects based on their similarity. If the difference electron density at a particular voxel in the time-dependent difference electron density (TDED) maps is sensitive to the presence of one and only one intermediate, then its temporal evolution will exactly parallel the concentration profile of that intermediate with time. The rationale is therefore to cluster voxels with respect to the shapes of their TDEDs, so that each group or cluster of voxels corresponds to one structural intermediate. Clusters of voxels whose TDEDs reflect the presence of two or more specific intermediates can also be identified. From such groupings one can then infer the number of intermediates, obtain their time-independent difference density characteristics, and refine the structure of each intermediate. We review the principles of cluster analysis and clustering algorithms in a crystallographic context, and describe the application of the method to simulated and experimental time-resolved crystallographic data for the photocycle of photoactive yellow protein. PMID:21244840

  16. European Working Time Directive and doctors' health: a systematic review of the available epidemiological evidence.

    Science.gov (United States)

    Rodriguez-Jareño, Maria Cruz; Demou, Evangelia; Vargas-Prada, Sergio; Sanati, Kaveh A; Skerjanc, Alenka; Reis, Pedro G; Helimäki-Aro, Ritva; Macdonald, Ewan B; Serra, Consol

    2014-07-07

    To summarise the available scientific evidence on the health effects of exposure to working beyond the limit number of hours established by the European Working Time Directive (EWTD) on physicians. A systematic literature search was conducted in PubMed and EMBASE. Study selection, quality appraisal and data extraction were carried out by independent pairs of researchers using pre-established criteria. Physicians of any medical, surgical or community specialty, working in any possible setting (hospitals, primary healthcare, etc), as well as trainees, residents, junior house officers or postgraduate interns, were included. The total number of participants was 14 338. Health effects classified under the International Classification of Diseases (ICD-10). Over 3000 citations and 110 full articles were reviewed. From these, 11 studies of high or intermediate quality carried out in North America, Europe and Japan met the inclusion criteria. Six studies included medical residents, junior doctors or house officers and the five others included medical specialists or consultants, medical, dental, and general practitioners and hospital physicians. Evidence of an association was found between percutaneous injuries and road traffic accidents with extended long working hours (LWH)/days or very LWH/weeks. The evidence was insufficient for mood disorders and general health. No studies on other health outcomes were identified. LWH could increase the risk of percutaneous injuries and road traffic accidents, and possibly other incidents at work through the same pathway. While associations are clear, the existing evidence does not allow for an established causal or 'dose-response' relationship between LWH and incidents at work, or for a threshold number of extended hours above which there is a significantly higher risk and the hours physicians could work and remain safe and healthy. Policymakers should consider safety issues when working on relaxing EWTD for doctors. Published by the

  17. Chemometric brand differentiation of commercial spices using direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Pavlovich, Matthew J; Dunn, Emily E; Hall, Adam B

    2016-05-15

    Commercial spices represent an emerging class of fuels for improvised explosives. Being able to classify such spices not only by type but also by brand would represent an important step in developing methods to analytically investigate these explosive compositions. Therefore, a combined ambient mass spectrometric/chemometric approach was developed to quickly and accurately classify commercial spices by brand. Direct analysis in real time mass spectrometry (DART-MS) was used to generate mass spectra for samples of black pepper, cayenne pepper, and turmeric, along with four different brands of cinnamon, all dissolved in methanol. Unsupervised learning techniques showed that the cinnamon samples clustered according to brand. Then, we used supervised machine learning algorithms to build chemometric models with a known training set and classified the brands of an unknown testing set of cinnamon samples. Ten independent runs of five-fold cross-validation showed that the training set error for the best-performing models (i.e., the linear discriminant and neural network models) was lower than 2%. The false-positive percentages for these models were 3% or lower, and the false-negative percentages were lower than 10%. In particular, the linear discriminant model perfectly classified the testing set with 0% error. Repeated iterations of training and testing gave similar results, demonstrating the reproducibility of these models. Chemometric models were able to classify the DART mass spectra of commercial cinnamon samples according to brand, with high specificity and low classification error. This method could easily be generalized to other classes of spices, and it could be applied to authenticating questioned commercial samples of spices or to examining evidence from improvised explosives. Copyright © 2016 John Wiley & Sons, Ltd.

  18. European Working Time Directive and doctors’ health: a systematic review of the available epidemiological evidence

    Science.gov (United States)

    Rodriguez-Jareño, Maria Cruz; Demou, Evangelia; Vargas-Prada, Sergio; Sanati, Kaveh A; Škerjanc, Alenka; Reis, Pedro G; Helimäki-Aro, Ritva; Macdonald, Ewan B; Serra, Consol

    2014-01-01

    Objective To summarise the available scientific evidence on the health effects of exposure to working beyond the limit number of hours established by the European Working Time Directive (EWTD) on physicians. Design A systematic literature search was conducted in PubMed and EMBASE. Study selection, quality appraisal and data extraction were carried out by independent pairs of researchers using pre-established criteria. Setting Physicians of any medical, surgical or community specialty, working in any possible setting (hospitals, primary healthcare, etc), as well as trainees, residents, junior house officers or postgraduate interns, were included. Participants The total number of participants was 14 338. Primary and secondary outcome measures Health effects classified under the International Classification of Diseases (ICD-10). Results Over 3000 citations and 110 full articles were reviewed. From these, 11 studies of high or intermediate quality carried out in North America, Europe and Japan met the inclusion criteria. Six studies included medical residents, junior doctors or house officers and the five others included medical specialists or consultants, medical, dental, and general practitioners and hospital physicians. Evidence of an association was found between percutaneous injuries and road traffic accidents with extended long working hours (LWH)/days or very LWH/weeks. The evidence was insufficient for mood disorders and general health. No studies on other health outcomes were identified. Conclusions LWH could increase the risk of percutaneous injuries and road traffic accidents, and possibly other incidents at work through the same pathway. While associations are clear, the existing evidence does not allow for an established causal or ‘dose–response’ relationship between LWH and incidents at work, or for a threshold number of extended hours above which there is a significantly higher risk and the hours physicians could work and remain safe and healthy

  19. Direct analysis in real time mass spectrometry for analysis of sexual assault evidence.

    Science.gov (United States)

    Musah, Rabi A; Cody, Robert B; Dane, A John; Vuong, Angela L; Shepard, Jason R E

    2012-05-15

    Sexual assault crimes are vastly underreported and suffer from alarmingly low prosecution and conviction rates. The key scientific method to aid in prosecution of such cases is forensic DNA analysis, where biological evidence such as semen collected using a rape test kit is used to determine a suspect's DNA profile. However, the growing awareness by criminals of the importance of DNA in the prosecution of sexual assaults has resulted in increased condom use by assailants as a means to avoid leaving behind their DNA. Thus, other types of trace evidence are important to help corroborate victims' accounts, exonerate the innocent, link suspects to the crime, or confirm penetration. Direct Analysis in Real Time Mass Spectrometry (DART-MS) was employed for the comprehensive characterization of non-DNA trace evidence associated with sexual assault. The ambient ionization method associated with DART-MS is extremely rapid and samples are processed instantaneously, without the need for extraction, sample preparation, or other means that might compromise forensic evidence for future analyses. In a single assay, we demonstrated the ability to identify lubricant formulations associated with sexual assault, such as the spermicide nonoxynol-9, compounds used in condom manufacture, and numerous other trace components as probative evidence. In addition, the method can also serve to identify compounds within trace biological residues, such as fatty acids commonly identified in latent fingerprints. Characterization of lubricant residues as probative evidence serves to establish a connection between the victim and the perpetrator, and the availability of these details may lead to higher rates of prosecution and conviction, as well as more severe penalties. The methodology described here opens the way for the adoption of a comprehensive, rapid, and sensitive analysis for use in crime labs, while providing knowledge that can inform and guide criminal justice policy and practice

  20. Unifying Pore Network Modeling, Continuous Time Random Walk Theory and Experiment - Accomplishments and Future Directions

    Science.gov (United States)

    Bijeljic, B.

    2008-05-01

    This talk will describe and highlight the advantages offered by a methodology that unifies pore network modeling, CTRW theory and experiment in description of solute dispersion in porous media. Solute transport in a porous medium is characterized by the interplay of advection and diffusion (described by Peclet number, Pe) that cause spreading of solute particles. This spreading is traditionally described by dispersion coefficients, D, defined by σ 2 = 2Dt, where σ 2 is the variance of the solute position and t is the time. Using a pore-scale network model based on particle tracking, the rich Peclet- number dependence of dispersion coefficient is predicted from first principles and is shown to compare well with experimental data for restricted diffusion, transition, power-law and mechanical dispersion regimes in the asymptotic limit. In the asymptotic limit D is constant and can be used in an averaged advection-dispersion equation. However, it is highly important to recognize that, until the velocity field is fully sampled, the particle transport is non-Gaussian and D possesses temporal or spatial variation. Furthermore, temporal probability density functions (PDF) of tracer particles are studied in pore networks and an excellent agreement for the spectrum of transition times for particles from pore to pore is obtained between network model results and CTRW theory. Based on the truncated power-law interpretation of PDF-s, the physical origin of the power-law scaling of dispersion coefficient vs. Peclet number has been explained for unconsolidated porous media, sands and a number of sandstones, arriving at the same conclusion from numerical network modelling, analytic CTRW theory and experiment. Future directions for further applications of the methodology presented are discussed in relation to the scale- dependent solute dispersion and reactive transport. Significance of pre-asymptotic dispersion in porous media is addressed from pore-scale upwards and the impact

  1. An investigation into how the European Working Time Directive has affected anaesthetic training

    Directory of Open Access Journals (Sweden)

    Bowhay Andrew R

    2008-08-01

    Full Text Available Abstract Background The European Working Time Directive (EWTD became law in 1993 but only applied to doctors in training in the United Kingdom in 2004. The trainees have in consequence had a reduction in their working hours but also a change to a shift pattern of working. For craft specialities, such as anaesthesia, there are concerns that a reduction in working hours has also led to a reduction in the time available for learning and that ultimately this may affect patient care. However, there is scant research on the perceptions of trainees concerning the impact of the EWTD on their training and working lives. This study investigated what the anaesthetic Specialist Registrars (SpRs on the Mersey Deanery SpR rotation perceived to be training and also what effect the EWTD has had on that training and their quality of life, both within and outside work. Methods The project was a cross sectional survey, using a quantitative questionnaire with qualitative free text comments which were aggregated into overarching themes and sub themes. Results 117 SpRs were sent questionnaires in April 2005; 73 completed questionnaires were returned (response rate 62.4%. Hierarchies of training opportunities emerged with training by consultants being most valued. 71.8% (95% CI 60.7 – 81.3 of trainees believed the EWTD has had a deleterious effect on their training and experience and 74.3% (95% CI 63.2 – 83.4 thought that they will be less prepared for a consultant post. 69.9% (95% CI 58.7 – 79.5 considered that their quality of life outside work had deteriorated, with only 15% (95% CI 8.3 – 24.6 finding improvement. 38.6% (95% CI 27.8 – 50.3 felt that they were not functioning as well as doctors, only 14.3% (95% CI 7.6 – 23.9 noting improvement. The trainees were still positive about anaesthesia and 73.2% (95% CI 62.2 – 82.5 would recommend this specialty to a student. Conclusion The majority of anaesthetic SpRs in the Mersey Deanery have not welcomed

  2. An investigation into how the European Working Time Directive has affected anaesthetic training.

    Science.gov (United States)

    Bowhay, Andrew R

    2008-08-12

    The European Working Time Directive (EWTD) became law in 1993 but only applied to doctors in training in the United Kingdom in 2004. The trainees have in consequence had a reduction in their working hours but also a change to a shift pattern of working. For craft specialities, such as anaesthesia, there are concerns that a reduction in working hours has also led to a reduction in the time available for learning and that ultimately this may affect patient care. However, there is scant research on the perceptions of trainees concerning the impact of the EWTD on their training and working lives. This study investigated what the anaesthetic Specialist Registrars (SpRs) on the Mersey Deanery SpR rotation perceived to be training and also what effect the EWTD has had on that training and their quality of life, both within and outside work. The project was a cross sectional survey, using a quantitative questionnaire with qualitative free text comments which were aggregated into overarching themes and sub themes. 117 SpRs were sent questionnaires in April 2005; 73 completed questionnaires were returned (response rate 62.4%). Hierarchies of training opportunities emerged with training by consultants being most valued. 71.8% (95% CI 60.7-81.3) of trainees believed the EWTD has had a deleterious effect on their training and experience and 74.3% (95% CI 63.2-83.4) thought that they will be less prepared for a consultant post. 69.9% (95% CI 58.7-79.5) considered that their quality of life outside work had deteriorated, with only 15% (95% CI 8.3-24.6) finding improvement. 38.6% (95% CI 27.8-50.3) felt that they were not functioning as well as doctors, only 14.3% (95% CI 7.6-23.9) noting improvement. The trainees were still positive about anaesthesia and 73.2% (95% CI 62.2-82.5) would recommend this specialty to a student. The majority of anaesthetic SpRs in the Mersey Deanery have not welcomed the changes brought by the EWTD to their training, experience and quality of life

  3. Inhomogeneities detection in annual precipitation time series in Portugal using direct sequential simulation

    Science.gov (United States)

    Caineta, Júlio; Ribeiro, Sara; Costa, Ana Cristina; Henriques, Roberto; Soares, Amílcar

    2014-05-01

    Climate data homogenisation is of major importance in monitoring climate change, the validation of weather forecasting, general circulation and regional atmospheric models, modelling of erosion, drought monitoring, among other studies of hydrological and environmental impacts. This happens because non-climate factors can cause time series discontinuities which may hide the true climatic signal and patterns, thus potentially bias the conclusions of those studies. In the last two decades, many methods have been developed to identify and remove these inhomogeneities. One of those is based on geostatistical simulation (DSS - direct sequential simulation), where local probability density functions (pdf) are calculated at candidate monitoring stations, using spatial and temporal neighbouring observations, and then are used for detection of inhomogeneities. This approach has been previously applied to detect inhomogeneities in four precipitation series (wet day count) from a network with 66 monitoring stations located in the southern region of Portugal (1980-2001). This study revealed promising results and the potential advantages of geostatistical techniques for inhomogeneities detection in climate time series. This work extends the case study presented before and investigates the application of the geostatistical stochastic approach to ten precipitation series that were previously classified as inhomogeneous by one of six absolute homogeneity tests (Mann-Kendall test, Wald-Wolfowitz runs test, Von Neumann ratio test, Standard normal homogeneity test (SNHT) for a single break, Pettit test, and Buishand range test). Moreover, a sensibility analysis is implemented to investigate the number of simulated realisations that should be used to accurately infer the local pdfs. Accordingly, the number of simulations per iteration is increased from 50 to 500, which resulted in a more representative local pdf. A set of default and recommended settings is provided, which will help

  4. Why hasn’t Macedonia succeeded for a long time in absorbing Foreign Direct Investment

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Nasir Selimi

    2015-06-01

    Full Text Available Recently almost all countries of the world without exception developed countries or the developing countries are attracting foreign direct investments. The reason is that there is no dilemma that benefits of foreign direct investments in the host countries as well as domestic countries are greater than the damage that can have. Western Balkan countries also follow this trend for attracting foreign direct investment. Some of them have achieved notable successes, while the others have achieved less success.  Macedonia is a country that during the last two decades ranks among the countries with smaller foreign direct investments. In the paper which I have chosen to analyze, in the start I gave a general overview of the meaning, role and importance of foreign direct investments for economic development of a country.  Later I have analyzed the trend of foreign direct investments in the region, and especially in Macedonia. At the end sought and given reasons of locking foreign direct investment in Macedonia and recommendations to overcome such a situation.

  5. When do gamblers help themselves? Self-discontinuity increases self-directed change over time.

    Science.gov (United States)

    Kim, Hyoun S; Wohl, Michael J A; Salmon, Melissa; Santesso, Diane

    2017-01-01

    Most disordered gamblers fail to take the necessary action to change their behavior. When action is taken, it is typically done under self-direction. Yet, little is known about what motivates gamblers to engage in self-directed change as researchers have focused almost exclusively on barriers to treatment seeking. Herein, we tested whether self-discontinuity (i.e., the notion that the self has undergone fundamental changes as a result of one's gambling) predicts self-directed change among gamblers experiencing sub-clinical levels of disordered gambling. Further, we tested whether this relationship would hold when controlling for feelings of shame and guilt about one's gambling as well as self-stigma as a disordered gambler (i.e., known barriers to change). To this end, 195 gamblers from the community completed a questionnaire battery that contained the variables of interest. Six months later, participants were re-contacted to assess whether they engaged in self-directed change. As hypothesized, the likelihood that self-directed change was attempted increased to the extent participants reported feeling self-discontinuous - an effect that remained significant when controlling for shame, guilt, and self-stigma. Results suggest that heightening the awareness that the gambling has fundamentally changed the self increases the likelihood of gamblers taking action to change their disordered gambling behaviors. Copyright © 2016. Published by Elsevier Ltd.

  6. Get a Life? The Impact of the European Working Time Directive: The Case of UK Senior Doctors.

    Science.gov (United States)

    Dolton, Peter J; Kidd, Michael P; Fooken, Jonas

    2015-10-01

    This paper seeks to identify the effect of the implementation of the European Working Time Directive on the working hours of UK doctors. The Labour Force Survey is used to compare the working hours of doctors with a variety of control groups before and after the implementation of the directive. The controls include those unconstrained by the directive and doctor counterparts working in Europe. We use differences-in-differences and matching methods to estimate the impact of this natural experiment, distinguishing between the anticipation and enactment of the European Working Time Directive. We find that the legislation reduced the hours of senior doctors by around 8 hours in total including the component attributable to anticipation effects and allowing for (exogenously set) rising wages. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.

  7. Freehand direct arthrography of the shoulder using near real-time guidance in an open 1.0-T MRI scanner

    Energy Technology Data Exchange (ETDEWEB)

    Wybranski, Christian [University Hospital of Cologne, Institute of Diagnostic and Interventional Radiology, Cologne (Germany); Adamchic, Ilya; Ricke, Jens; Fischbach, Frank; Fischbach, Katharina [Otto-von-Guericke University Medical School, Department of Radiology and Nuclear Medicine, Magdeburg (Germany); Roehl, Friedrich-Wilhelm [Otto-von-Guericke University Medical School, Institute of Biometry and Medical Informatics, Magdeburg (Germany)

    2017-01-15

    To assess the technical success and duration of magnetic resonance imaging (MRI)-guided freehand direct shoulder arthrography (FDSA) with near real-time imaging implemented in a routine shoulder MRI examination on an open 1.0-T MRI scanner, and to assess the learning curve of residents new to this technique. An experienced MRI interventionalist (the expert) performed 125 MRI-guided FDSA procedures, and 75 patients were treated by one of three residents without previous experience in MRI-guided FDSA. Technical success rate and duration of MRI-guided FDSA of the expert and the residents were compared. The residents' learning curves were assessed. The occurrence of extra-articular deposition and leakage of contrast media from the puncture site and the subsequent impairment of image interpretation were retrospectively analyzed. Overall technical success was 97.5 %. The expert needed overall fewer puncture needle readjustments and was faster at puncture needle positioning (p < 0.01). The learning curve of the residents, however, was steep. They leveled with the performance of the expert after ∼ 15 interventions. With a minimal amount of training all steps of MRI-guided FDSA can be performed in ≤10 min. Magnetic resonance-guided FDSA in an open 1.0-T MRI scanner can be performed with high technical success in a reasonably short amount of time. Only a short learning curve is necessary to achieve expert level. (orig.)

  8. Mapping geological structures in bedrock via large-scale direct current resistivity and time-domain induced polarization tomography

    DEFF Research Database (Denmark)

    Rossi, Matteo; Olsson, Per-Ivar; Johansson, Sara

    2017-01-01

    -current resistivity distribution of the subsoil and the phase of the complex conductivity using a constant-phase angle model. The joint interpretation of electrical resistivity and induced-polarization models leads to a better understanding of complex three-dimensional subsoil geometries. The results have been......An investigation of geological conditions is always a key point for planning infrastructure constructions. Bedrock surface and rock quality must be estimated carefully in the designing process of infrastructures. A large direct-current resistivity and time-domain induced-polarization survey has......, there are northwest-trending Permian dolerite dykes that are less deformed. Four 2D direct-current resistivity and time-domain induced-polarization profiles of about 1-km length have been carefully pre-processed to retrieve time-domain induced polarization responses and inverted to obtain the direct...

  9. Efficient accurate syntactic direct translation models: one tree at a time

    NARCIS (Netherlands)

    Hassan, H.; Sima'an, K.; Way, A.

    2011-01-01

    A challenging aspect of Statistical Machine Translation from Arabic to English lies in bringing the Arabic source morpho-syntax to bear on the lexical as well as word-order choices of the English target string. In this article, we extend the feature-rich discriminative Direct Translation Model 2

  10. Direct imaging of turbid media using long-time back-scattered photons, a numerical study

    International Nuclear Information System (INIS)

    Boulanger, Joan; Liu, Fengshan; El Akel, Azad; Charette, Andre

    2006-01-01

    Direct imaging is a convenient way to obtain information on the interior of a semi-transparent turbid material by non-invasive probing using laser beams. The major difficulty is linked to scattering which scrambles the directional information coming from the laser beam. It is found in this paper that the long-term multiple-scattered reflected photons may provide structural information on the inside of a material, which offers an interesting alternative to using information only from un-scattered or least-scattered photons as obtained from current direct imaging set-ups for thin media. Based on some observations on a non-homogeneous three layered 1-D slab irradiated by a laser pulse, a direct probing methodology making use of the long-term back-scattered photons is illustrated to recover inclusions positions in a turbid 2-D medium. First, the numerical model is presented. Second, an extended parametrical study is conducted on 1-D homogeneous and non-homogeneous slabs with different laser pulse durations. It is found that the reflected asymptotic logarithmic slope carries information about the presence of the inclusion and that short laser pulses are not necessary since only the decaying parts of the remanent optical signature is important. Longer laser pulses allow a higher level of energy injection and signal to noise ratio. Third, those observations are used for the probing of a 2-D non-homogeneous phantom. (author)

  11. Dependence of Excited State Potential Energy Surfaces on the Spatial Overlap of the Kohn-Sham Orbitals and the Amount of Nonlocal Hartree-Fock Exchange in Time-Dependent Density Functional Theory.

    Science.gov (United States)

    Plötner, Jürgen; Tozer, David J; Dreuw, Andreas

    2010-08-10

    Time-dependent density functional theory (TDDFT) with standard GGA or hybrid exchange-correlation functionals is not capable of describing the potential energy surface of the S1 state of Pigment Yellow 101 correctly; an additional local minimum is observed at a twisted geometry with substantial charge transfer (CT) character. To investigate the influence of nonlocal exact orbital (Hartree-Fock) exchange on the shape of the potential energy surface of the S1 state in detail, it has been computed along the twisting coordinate employing the standard BP86, B3LYP, and BHLYP xc-functionals as well as the long-range separated (LRS) exchange-correlation (xc)-functionals LC-BOP, ωB97X, ωPBE, and CAM-B3LYP and compared to RI-CC2 benchmark results. Additionally, a recently suggested Λ-parameter has been employed that measures the amount of CT in an excited state by calculating the spatial overlap of the occupied and virtual molecular orbitals involved in the transition. Here, the error in the calculated S1 potential energy curves at BP86, B3LYP, and BHLYP can be clearly related to the Λ-parameter, i.e., to the extent of charge transfer. Additionally, it is demonstrated that the CT problem is largely alleviated when the BHLYP xc-functional is employed, although it still exhibits a weak tendency to underestimate the energy of CT states. The situation improves drastically when LRS-functionals are employed within TDDFT excited state calculations. All tested LRS-functionals give qualitatively the correct potential energy curves of the energetically lowest excited states of P. Y. 101 along the twisting coordinate. While LC-BOP and ωB97X overcorrect the CT problem and now tend to give too large excitation energies compared to other non-CT states, ωPBE and CAM-B3LYP are in excellent agreement with the RI-CC2 results, with respect to both the correct shape of the potential energy curve as well as the absolute values of the calculated excitation energies.

  12. Comparison of direct and geodetic mass balances on a multi-annual time scale

    Directory of Open Access Journals (Sweden)

    A. Fischer

    2011-02-01

    Full Text Available The geodetic mass balances of six Austrian glaciers over 19 periods between 1953 and 2006 are compared to the direct mass balances over the same periods. For two glaciers, Hintereisferner and Kesselwandferner, case studies showing possible reasons for discrepancies between the geodetic and the direct mass balance are presented. The mean annual geodetic mass balance for all periods is −0.5 m w.e. a−1, the mean annual direct mass balance −0.4 m w.e. a−1. The mean cumulative difference is −0.6 m w.e., the minimum −7.3 m w.e., and the maximum 5.6 m w.e. The accuracy of geodetic mass balance may depend on the accuracy of the DEMs, which ranges from 2 m w.e. for photogrammetric data to 0.02 m w.e. for airborne laser scanning (LiDAR data. Basal melt, seasonal snow cover, and density changes of the surface layer also contribute up to 0.7 m w.e. to the difference between the two methods over the investigated period of 10 yr. On Hintereisferner, the fraction of area covered by snow or firn has been changing within 1953–2006. The accumulation area is not identical with the firn area, and both are not coincident with areas of volume gain. Longer periods between the acquisition of the DEMs do not necessarily result in a higher accuracy of the geodetic mass balance. Trends in the difference between the direct and the geodetic data vary from glacier to glacier and can differ systematically for specific glaciers under specific types of climate forcing. Ultimately, geodetic and direct mass balance data are complementary, and great care must be taken when attempting to combine them.

  13. Effects of timing of signal indicating jump directions on knee biomechanics in jump-landing-jump tasks.

    Science.gov (United States)

    Stephenson, Mitchell L; Hinshaw, Taylour J; Wadley, Haley A; Zhu, Qin; Wilson, Margaret A; Byra, Mark; Dai, Boyi

    2018-03-01

    A variety of the available time to react (ATR) has been utilised to study knee biomechanics during reactive jump-landing tasks. The purpose was to quantify knee kinematics and kinetics during a jump-land-jump task of three possible directions as the ATR was reduced. Thirty-four recreational athletes performed 45 trials of a jump-land-jump task, during which the direction of the second jump (lateral, medial or vertical) was indicated before they initiated the first jump, the instant they initiated the first jump, 300 ms before landing, 150 ms before landing or at the instant of landing. Knee joint angles and moments close to the instant of landing were significantly different when the ATR was equal to or more than 300 ms before landing, but became similar when the ATR was 150 ms or 0 ms before landing. As the ATR was decreased, knee moments decreased for the medial jump direction, but increased for the lateral jump direction. When the ATR is shorter than an individual's reaction time, the movement pattern cannot be pre-planned before landing. Knee biomechanics are dependent on the timing of the signal and the subsequent jump direction. Precise control of timing and screening athletes with low ATR are suggested.

  14. The Effect of the Rolling Direction, Temperature, and Etching Time on the Photochemical Machining of Monel 400 Microchannels

    Directory of Open Access Journals (Sweden)

    Deepakkumar H. Patil

    2016-01-01

    Full Text Available The present paper describes the effect of the rolling direction on the quality of microchannels manufactured using photochemical machining (PCM of Monel 400. Experiments were carried out to fabricate microchannels along and across the rolling direction to investigate the effect of the grain orientation on microchannel etching. The input parameters considered were channel width and rolling direction, whereas the depth of etch was the response parameters. Different channels of widths of 60, 100, 150, 200, and 250 μm were etched. The effects of the etching time and temperature of the etchant solution on the undercut and depth of the microchannels were studied. For good quality microchannels, the effects of spinning time, spinning speed, exposure time, and photoresist film strength were also taken into consideration. Optimized values of the above were used for the experimentation. The results show that the depth of etch of the microchannel increases more along the rolling direction than across the rolling direction. The channel width and depth are significantly affected by the etching time and temperature. The proposed study reports an improvement in the quality of microchannels produced using PCM.

  15. It’s Time to Shine the Light on Direct-to-Consumer Advertising

    Science.gov (United States)

    Mackey, Tim K.; Liang, Bryan A.

    2015-01-01

    Pharmaceutical marketing is undergoing a transition as the business, delivery, and consumption of health care have increasingly become part of a growing digital landscape. Changes in pharmaceutical promotion also coincide with federal “sunshine” regulations newly implemented under the Affordable Care Act that require disclosure of certain marketing and industry payments to physicians. Collectively, these trends could lead to fundamental shifts in physician-directed and direct-to-consumer advertising (DTCA) that have yet to be adequately identified or explored. In response, we advocate for greater DTCA transparency, especially in the emerging digital forms of DTCA, to complement forthcoming sunshine transparency data. This will allow more robust study and understanding of changes in overall pharmaceutical marketing trends and their impact on health care consumption and behavior. This can also lead to more targeted state and federal policy interventions leveraging existing federal transparency regulations to ensure appropriate marketing, sales, and consumption of pharmaceutical products. PMID:25583897

  16. It's time to shine the light on direct-to-consumer advertising.

    Science.gov (United States)

    Mackey, Tim K; Liang, Bryan A

    2015-01-01

    Pharmaceutical marketing is undergoing a transition as the business, delivery, and consumption of health care have increasingly become part of a growing digital landscape. Changes in pharmaceutical promotion also coincide with federal "sunshine" regulations newly implemented under the Affordable Care Act that require disclosure of certain marketing and industry payments to physicians. Collectively, these trends could lead to fundamental shifts in physician-directed and direct-to-consumer advertising (DTCA) that have yet to be adequately identified or explored. In response, we advocate for greater DTCA transparency, especially in the emerging digital forms of DTCA, to complement forthcoming sunshine transparency data. This will allow more robust study and understanding of changes in overall pharmaceutical marketing trends and their impact on health care consumption and behavior. This can also lead to more targeted state and federal policy interventions leveraging existing federal transparency regulations to ensure appropriate marketing, sales, and consumption of pharmaceutical products. © 2015 Annals of Family Medicine, Inc.

  17. The Anesthesia Preoperative Evaluation Clinic (APEC): a prospective randomized controlled trial assessing impact on consultation time, direct costs, patient education and satisfaction with anesthesia care.

    Science.gov (United States)

    Schiff, J H; Frankenhauser, S; Pritsch, M; Fornaschon, S A; Snyder-Ramos, S A; Heal, C; Schmidt, K; Martin, E; Böttiger, B W; Motsch, J

    2010-07-01

    Anesthetic preoperative evaluation clinics (APECs) are relatively new institutions. Although cost effective, APECs have not been universally adopted in Europe. The aim of this study was to compare preoperative anesthetic assessment in wards with an APEC, assessing time, information gain, patient satisfaction and secondary costs. Two hundred and seven inpatients were randomized to be assessed at the APEC or on the ward by the same two senior anesthetists. The outcomes measured were the length of time for each consultation, the amount of information passed on to patients and the level of patient satisfaction. The consultation time was used to calculate impact on direct costs. A multivariate analysis was conducted to detect confounding variables. Ninety-four patients were seen in the APEC, and 78 were seen on the ward. The total time for the consultation was shorter for the APEC (mean 8.4 minutes [Plocation of the consultation. Gain in information was significantly influenced by age, education and the location of the visit. The APEC reduced consultation times and costs and had a positive impact on patient education. The cost savings are related to personnel costs and, therefore, are independent of other potential savings of an APEC, whereas global patient satisfaction remains unaltered.

  18. Governance of EU labour law: implementation of the EU Working Time Directive in the Netherlands

    NARCIS (Netherlands)

    Sol, E.; Ramos Martín, N.; Barbier, J.-C.; Rogowski, R.; Colomb, F.

    2015-01-01

    This chapter deals with the challenges that European law poses for national legislation and practices regarding working time. The regulation of working time is situated at the crossroads of health and safety regulations and employment protection. The European Union has acknowledged the need to

  19. The space-time evolution of an electrical discharge directed by a laser spark

    International Nuclear Information System (INIS)

    Asinovskii, E.I.; Vasilyak, L.M.; Unkovskii, S.Yu.

    1992-01-01

    The study of electrical discharges directed by a laser spark has been made necessary by the creation of new types of switches, plasma antennas, and lightning rods, channels for the transport of charged particle beams in inertial thermonuclear fusion devices, and also for modeling the processes in streak lightning. For the most part, previous studies have explored the feasibility of creating such discharges, depending on experimental conditions, and proposed possible mechanisms for the development of discharges, e.g., the stepwise nature of its propagation. A model was proposed in which the discharge front propagates as an ionization wave. This model was based on measurements of the electric potential along the trajectory of a directed discharge. To construct a model and obtain directed discharges with prescribed parameters, one must know the mechanisms of discharge development. In this work, the authors report the results of an electrooptical study of the origin and motion of luminous fronts of ionization waves in an electrical discharge during its initiation, both for a single breakdown site and for a long laser spark with a large number of laser breakdown sites. Results are presented of our study of the stability of a discharge for a current flow of long duration

  20. Distributed Adaptive Finite-Time Approach for Formation-Containment Control of Networked Nonlinear Systems Under Directed Topology.

    Science.gov (United States)

    Wang, Yujuan; Song, Yongduan; Ren, Wei

    2017-07-06

    This paper presents a distributed adaptive finite-time control solution to the formation-containment problem for multiple networked systems with uncertain nonlinear dynamics and directed communication constraints. By integrating the special topology feature of the new constructed symmetrical matrix, the technical difficulty in finite-time formation-containment control arising from the asymmetrical Laplacian matrix under single-way directed communication is circumvented. Based upon fractional power feedback of the local error, an adaptive distributed control scheme is established to drive the leaders into the prespecified formation configuration in finite time. Meanwhile, a distributed adaptive control scheme, independent of the unavailable inputs of the leaders, is designed to keep the followers within a bounded distance from the moving leaders and then to make the followers enter the convex hull shaped by the formation of the leaders in finite time. The effectiveness of the proposed control scheme is confirmed by the simulation.

  1. Direct measurement of time dependent diffusion for Ag and Au under ambient conditions

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Pil Sun; Jo, Han Yeol; Kim, Tae Kyeong [Hankuk University of Foreign Studies, Yongin (Korea, Republic of)

    2014-12-15

    Time-dependent diffusion for Ag and Au metal atoms was measured using the scanning tunneling microscope break-junction technique in ambient conditions. We observed that Ag contacts do not form long single-atomic chains compared to Au contacts during the elongation of each metal electrode, and Ag atoms diffuse more quickly than Au atoms after metal contact rupture. This is consistent with previous results of molecular dynamic simulations. Further, we found a correlation between diffusion length and the evolution time on an atomic scale to reveal the time-dependent diffusion for Ag and Au metal atoms.

  2. Direct Analysis in Real Time Mass Spectrometry of Potential By-Products from Homemade Nitrate Ester Explosive Synthesis

    OpenAIRE

    Sisco, Edward; Forbes, Thomas P.

    2015-01-01

    This work demonstrates the coupling of direct analysis in real time (DART) ionization with time-of-flight mass spectrometry (MS) in an off-axis configuration for the trace detection and analysis of potential partially nitrated and dimerized by-products of homemade nitrate ester explosive synthesis. Five compounds relating to the synthesis of nitroglycerin (NG) and pentaerythritol tetranitrate (PETN) were examined. Deprotonated ions and adducts with molecular oxygen, nitrite, and nitrate were ...

  3. Self-Regulation of the Primary Auditory Cortex Attention Via Directed Attention Mediated By Real Time fMRI Neurofeedback

    Science.gov (United States)

    2017-05-05

    NELSON FROM: 59 MDW /SGYU SUBJECT: Professional Presentation Approval 1. Your paper, entitled Self - regulation of the Primary Auditory Cortex Attention via...DATE Sherwood - p.1 Self - regulation of the primary auditory cortex attention via directed attention mediated by real-time fMRI neurofeedback M S...auditory cortex hyperactivity by self - regulation of the primary auditory cortex (A 1) based on real-time functional magnetic resonance imaging neurofeedback

  4. Real-time positioning technology in horizontal directional drilling based on magnetic gradient tensor measurement

    Science.gov (United States)

    Deng, Guoqing; Yao, Aiguo

    2017-04-01

    Horizontal directional drilling (HDD) technology has been widely used in Civil Engineering. The dynamic position of the drill bit during construction is one of significant facts determining the accuracy of the trajectory of HDD. A new method now has been proposed to detecting the position of drill bit by measuring the magnetic gradient tensor of the ground solenoid magnetic beacon. Compared with traditional HDD positioning technologies, this new model is much easier to apply with lower request for construction sites and higher positioning efficiency. A direct current (DC) solenoid as a magnetic dipole is placed on ground near the drill bit, and related sensors array which contains four Micro-electromechanical Systems (MEMS ) tri-axial magnetometers, one MEMS tri-axial accelerometer and one MEMS tri-axial gyroscope is set up for measuring the magnetic gradient tensor of the magnetic dipole. The related HDD positioning model has been established and simulation experiments have been carried out to verify the feasibility and reliability of the proposed method. The experiments show that this method has good positioning accuracy in horizontal and vertical direction, and totally avoid the impact of the environmental magnetic field. It can be found that the posture of the magnetic beacon will impact the remote positioning precision within valid positioning range, and the positioning accuracy is higher with longer baseline for limited space in drilling tools. The results prove that the relative error can be limited in 2% by adjusting position of the magnetic beacon, the layers of the enameled coil, the sensitive of magnetometers and the baseline distance. Conclusion can be made that this new method can be applied in HDD positioning with better effect and wider application range than traditional method.

  5. Spectrum, time structure and direction of incidence of the August 16, 1976 gamma ray burst

    International Nuclear Information System (INIS)

    Sommer, H.; Mueller, D.; Horstman, H.; Bassani, L.

    1977-01-01

    Two major bursts of energetic photons have been recorded with a new balloon-borne instrument during the second transatlantic flight in 1976: One in coincidence with a type III solar radio burst on August 16 and a very energetic gamma ray burst of non-solar origin starting at 16:15.5 UT of August 16. Spectral information of the gamma ray burst has been obtained up to 2 MeV. A crude position of the burst source has been derived from data of a directional detector array after correcting for absorption and scattering in the earth's atmosphere. (author)

  6. Time-resolved cathodoluminescence microscopy with sub-nanosecond beam blanking for direct evaluation of the local density of states

    NARCIS (Netherlands)

    Moerland, R.J.; Weppelman, I.G.C.; Garming, M.W.H.; Kruit, P.; Hoogenboom, J.P.

    2016-01-01

    We show cathodoluminescence-based time-resolved electron beam spectroscopy in order to directly probe the spontaneous emission decay rate that is modified by the local density of states in a nanoscale environment. In contrast to dedicated laser-triggered electron-microscopy setups, we use commercial

  7. Use of time and materials and cost reimbursement subcontracts for remedial actions under the alternative remedial contracting strategy contracts. Directive

    International Nuclear Information System (INIS)

    1992-01-01

    The directive is intended to establish agency guidance on the use of time and materials and cost reimbursement contracts for remedial actions in general and to provide specific instruction regarding the use of these approaches in subcontracting under the Alternative Remedial Contracting Strategy (ARCS) contracts

  8. Differential Timing of Spider Mite-Induced Direct and Indirect Defenses in Tomato Plants1[w

    Science.gov (United States)

    Kant, Merijn R.; Ament, Kai; Sabelis, Maurice W.; Haring, Michel A.; Schuurink, Robert C.

    2004-01-01

    Through a combined metabolomics and transcriptomics approach we analyzed the events that took place during the first 5 d of infesting intact tomato (Lycopersicon esculentum) plants with spider mites (Tetranychus urticae). Although the spider mites had caused little visible damage to the leaves after 1 d, they had already induced direct defense responses. For example, proteinase inhibitor activity had doubled and the transcription of genes involved in jasmonate-, salicylate-, and ethylene-regulated defenses had been activated. On day four, proteinase inhibitor activity and particularly transcript levels of salicylate-regulated genes were still maintained. In addition, genes involved in phospholipid metabolism were up-regulated on day one and those in the secondary metabolism on day four. Although transcriptional up-regulation of the enzymes involved in the biosynthesis of monoterpenes and diterpenes already occurred on day one, a significant increase in the emission of volatile terpenoids was delayed until day four. This increase in volatile production coincided with the increased olfactory preference of predatory mites (Phytoseiulus persimilis) for infested plants. Our results indicate that tomato activates its indirect defenses (volatile production) to complement the direct defense response against spider mites. PMID:15122016

  9. First direct observation of time-reversal non-invariance in the neutral-kaon system

    CERN Document Server

    Angelopoulos, Angelos; Aslanides, Elie; Backenstoss, Gerhard; Bargassa, P; Behnke, O; Benelli, A; Bertin, V; Blanc, F; Bloch, P; Carlson, P J; Carroll, M; Cawley, E; Chertok, M B; Danielsson, M; Dejardin, M; Derré, J; Ealet, A; Eleftheriadis, C; Faravel, L; Fetscher, W; Fidecaro, Maria; Filipcic, A; Francis, D; Fry, J; Gabathuler, Erwin; Gamet, R; Gerber, H J; Go, A; Haselden, A; Hayman, P J; Henry-Coüannier, F; Hollander, R W; Jon-And, K; Kettle, P R; Kokkas, P; Kreuger, R; Le Gac, R; Leimgruber, F; Mandic, I; Manthos, N; Marel, Gérard; Mikuz, M; Miller, J; Montanet, François; Müller, A; Nakada, Tatsuya; Pagels, B; Papadopoulos, I M; Pavlopoulos, P; Polivka, G; Rickenbach, R; Roberts, B L; Ruf, T; Santoni, C; Schäfer, M; Schaller, L A; Schietinger, T; Schopper, A; Tauscher, Ludwig; Thibault, C; Touchard, F; Touramanis, C; van Eijk, C W E; Vlachos, S; Weber, P; Wigger, O; Wolter, M; Zavrtanik, D; Zimmerman, D

    1998-01-01

    We report on the first observation of time-reversal symmetry violation through a comparison of the probabilities of $\\bar{K}^0$ transforming into $K^0$ and $K^0$ into $\\bar{K}^0$ as a function of the neutral-kaon eigentime $t$. The comparison is based on the analysis of the neutral-kaon semileptonic decays recorded in the CPLEAR experiment. There, the strangeness of the neutral kaon at time $t=0$ was tagged by the kaon charge in the reaction $p\\bar{p} \\rightarrow K^{\\pm} \\pi^{\\mp} K^0(\\bar{K}^0)$ at rest, whereas the strangeness of the kaon at the decay time $t=\\tau$ was tagged by the lepton charge in the final state. An average decay-rate asymmetry \\begin{equation*} \\langle^{R(\\bar{K}^0_{t=0} \\to e^+\\pi^-\

  10. Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.

    Science.gov (United States)

    Zuccaro, Laura; Tesauro, Cinzia; Kurkina, Tetiana; Fiorani, Paola; Yu, Hak Ki; Knudsen, Birgitta R; Kern, Klaus; Desideri, Alessandro; Balasubramanian, Kannan

    2015-11-24

    Monolayer graphene field-effect sensors operating in liquid have been widely deployed for detecting a range of analyte species often under equilibrium conditions. Here we report on the real-time detection of the binding kinetics of the essential human enzyme, topoisomerase I interacting with substrate molecules (DNA probes) that are immobilized electrochemically on to monolayer graphene strips. By monitoring the field-effect characteristics of the graphene biosensor in real-time during the enzyme-substrate interactions, we are able to decipher the surface binding constant for the cleavage reaction step of topoisomerase I activity in a label-free manner. Moreover, an appropriate design of the capture probes allows us to distinctly follow the cleavage step of topoisomerase I functioning in real-time down to picomolar concentrations. The presented results are promising for future rapid screening of drugs that are being evaluated for regulating enzyme activity.

  11. A polynomial time algorithm for solving the maximum flow problem in directed networks

    International Nuclear Information System (INIS)

    Tlas, M.

    2015-01-01

    An efficient polynomial time algorithm for solving maximum flow problems has been proposed in this paper. The algorithm is basically based on the binary representation of capacities; it solves the maximum flow problem as a sequence of O(m) shortest path problems on residual networks with nodes and m arcs. It runs in O(m"2r) time, where is the smallest integer greater than or equal to log B , and B is the largest arc capacity of the network. A numerical example has been illustrated using this proposed algorithm.(author)

  12. Monitoring Distributed Real-Time Systems: A Survey and Future Directions

    Science.gov (United States)

    Goodloe, Alwyn E.; Pike, Lee

    2010-01-01

    Runtime monitors have been proposed as a means to increase the reliability of safety-critical systems. In particular, this report addresses runtime monitors for distributed hard real-time systems. This class of systems has had little attention from the monitoring community. The need for monitors is shown by discussing examples of avionic systems failure. We survey related work in the field of runtime monitoring. Several potential monitoring architectures for distributed real-time systems are presented along with a discussion of how they might be used to monitor properties of interest.

  13. A Robust Real Time Direction-of-Arrival Estimation Method for Sequential Movement Events of Vehicles.

    Science.gov (United States)

    Liu, Huawei; Li, Baoqing; Yuan, Xiaobing; Zhou, Qianwei; Huang, Jingchang

    2018-03-27

    Parameters estimation of sequential movement events of vehicles is facing the challenges of noise interferences and the demands of portable implementation. In this paper, we propose a robust direction-of-arrival (DOA) estimation method for the sequential movement events of vehicles based on a small Micro-Electro-Mechanical System (MEMS) microphone array system. Inspired by the incoherent signal-subspace method (ISM), the method that is proposed in this work employs multiple sub-bands, which are selected from the wideband signals with high magnitude-squared coherence to track moving vehicles in the presence of wind noise. The field test results demonstrate that the proposed method has a better performance in emulating the DOA of a moving vehicle even in the case of severe wind interference than the narrowband multiple signal classification (MUSIC) method, the sub-band DOA estimation method, and the classical two-sided correlation transformation (TCT) method.

  14. Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes

    DEFF Research Database (Denmark)

    Persson, F; Rossing, P; Schjoedt, K J

    2008-01-01

    Inhibition of renin with an active site inhibitor, aliskiren, lowers blood pressure (BP) in diabetic patients. Here, we studied the time course of the antihypertensive and antiproteinuric effect of renin inhibition in 15 patients with type 2 diabetes and elevated urinary albumin/creatinine ratios...

  15. Direct quantification of fungal DNA from soil substrate using real-time PCR.

    Science.gov (United States)

    Filion, Martin; St-Arnaud, Marc; Jabaji-Hare, Suha H

    2003-04-01

    Detection and quantification of genomic DNA from two ecologically different fungi, the plant pathogen Fusarium solani f. sp. phaseoli and the arbuscular mycorrhizal fungus Glomus intraradices, was achieved from soil substrate. Specific primers targeting a 362-bp fragment from the SSU rRNA gene region of G. intraradices and a 562-bp fragment from the F. solani f. sp. phaseoli translation elongation factor 1 alpha gene were used in real-time polymerase chain reaction (PCR) assays conjugated with the fluorescent SYBR(R) Green I dye. Standard curves showed a linear relation (r(2)=0.999) between log values of fungal genomic DNA of each species and real-time PCR threshold cycles and were quantitative over 4-5 orders of magnitude. Real-time PCR assays were applied to in vitro-produced fungal structures and sterile and non-sterile soil substrate seeded with known propagule numbers of either fungi. Detection and genomic DNA quantification was obtained from the different treatments, while no amplicon was detected from non-seeded non-sterile soil samples, confirming the absence of cross-reactivity with the soil microflora DNA. A significant correlation (Pgenomic DNA of F. solani f. sp. phaseoli or G. intraradices detected and the number of fungal propagules present in seeded soil substrate. The DNA extraction protocol and real-time PCR quantification assay can be performed in less than 2 h and is adaptable to detect and quantify genomic DNA from other soilborne fungi.

  16. Emergency department physicians spend only 25% of their working time on direct patient care

    DEFF Research Database (Denmark)

    Füchtbauer, Laila Maria; Nørgaard, Birgitte; Mogensen, Christian Backer

    2013-01-01

    In modern hospital medicine, there is a growing awareness of the need for efficient and secure -patient care. Authorities seek to improve this by adding requirements for documentation, administrative tasks and standardized patient programmes. However, it is rarely investigated how much time...

  17. Body temperature predicts the direction of internal desynchronization in humans isolated from time cues

    NARCIS (Netherlands)

    Daan, Serge; Honma, Sato; Honma, Ken-ichi

    2013-01-01

    This publication presents a new analysis of experiments that were carried out in human subjects in isolation from time cues, under supervision of Jurgen Aschoff and Rutger Wever at the Max Planck Institute for Behavioural Physiology (Erling-Andechs, Germany, 1964-1974). Mean rectal temperatures

  18. Direct measurements of relaxation times of phosphorus metabolites in the human myocardium

    International Nuclear Information System (INIS)

    Schindler, R.; Krahe, T.; Neubauer, S.; Hillenbrand, H.; Entzeroth, C.; Horn, M.; Lackner, K.; Ertl, G.

    1992-01-01

    The T 1 relaxation times of the phosphorus metabolites in human heart muscle measurable by 31 P-MR spectra were determined in 12 individuals using a 1.5 Tesla system. Several spectra were recorded consecutively with a pulse repetition time of 1.6s to 24 s. The T 1 times of creatine phosphate (CP), of γ-, α-, β-adenosintriphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) together with anorganic phosphate) and phosphodiester (PDE) showed mean measurements of 6.1±0.5, 5.4±0.5, 5.0±0.5, 5.8±1.0, 7.6±1.0, and 5.0±1.0s (M±SE). The accuracy of the ISIS technique was tested with a special phantom. T 1 times were also measured in standard solutions (20mM CP, 10mM ATP); CP was 8.7±0.2s and γ-ATP was 9.9±0.7s. Corrections for partially saturated 31 P-MR spectra - at least for CP/ATP ratios - are relatively small. (orig.) [de

  19. Scalability of Direct Solver for Non-stationary Cahn-Hilliard Simulations with Linearized time Integration Scheme

    KAUST Repository

    Woźniak, M.

    2016-06-02

    We study the features of a new mixed integration scheme dedicated to solving the non-stationary variational problems. The scheme is composed of the FEM approximation with respect to the space variable coupled with a 3-leveled time integration scheme with a linearized right-hand side operator. It was applied in solving the Cahn-Hilliard parabolic equation with a nonlinear, fourth-order elliptic part. The second order of the approximation along the time variable was proven. Moreover, the good scalability of the software based on this scheme was confirmed during simulations. We verify the proposed time integration scheme by monitoring the Ginzburg-Landau free energy. The numerical simulations are performed by using a parallel multi-frontal direct solver executed over STAMPEDE Linux cluster. Its scalability was compared to the results of the three direct solvers, including MUMPS, SuperLU and PaSTiX.

  20. Long Spin-Relaxation Times in a Transition-Metal Atom in Direct Contact to a Metal Substrate.

    Science.gov (United States)

    Hermenau, Jan; Ternes, Markus; Steinbrecher, Manuel; Wiesendanger, Roland; Wiebe, Jens

    2018-03-14

    Long spin-relaxation times are a prerequisite for the use of spins in data storage or nanospintronics technologies. An atomic-scale solid-state realization of such a system is the spin of a transition-metal atom adsorbed on a suitable substrate. For the case of a metallic substrate, which enables the direct addressing of the spin by conduction electrons, the experimentally measured lifetimes reported to date are on the order of only hundreds of femtoseconds. Here, we show that the spin states of iron atoms adsorbed directly on a conductive platinum substrate have a surprisingly long spin-relaxation time in the nanosecond regime, which is comparable to that of a transition metal atom decoupled from the substrate electrons by a thin decoupling layer. The combination of long spin-relaxation times and strong coupling to conduction electrons implies the possibility to use flexible coupling schemes to process the spin information.

  1. A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry.

    Directory of Open Access Journals (Sweden)

    Bárbara Angulo

    Full Text Available The objective of this study is to compare two EGFR testing methodologies (a commercial real-time PCR kit and a specific EGFR mutant immunohistochemistry, with direct sequencing and to investigate the limit of detection (LOD of both PCR-based methods. We identified EGFR mutations in 21 (16% of the 136 tumours analyzed by direct sequencing. Interestingly, the Therascreen EGFR Mutation Test kit was able to characterize as wild-type one tumour that could not be analyzed by direct sequencing of the PCR product. We then compared the LOD of the kit and that of direct sequencing using the available mutant tumours. The kit was able to detect the presence of a mutation in a 1% dilution of the total DNA in nine of the 18 tumours (50%, which tested positive with the real-time quantitative PCR method. In all cases, EGFR mutation was identified at a dilution of 5%. Where the mutant DNA represented 30% of the total DNA, sequencing was able to detect mutations in 12 out of 19 cases (63%. Additional experiments with genetically defined standards (EGFR ΔE746-A750/+ and EGFR L858R/+ yielded similar results. Immunohistochemistry (IHC staining with exon 19-specific antibody was seen in eight out of nine cases with E746-A750del detected by direct sequencing. Neither of the two tumours with complex deletions were positive. Of the five L858R-mutated tumours detected by the PCR methods, only two were positive for the exon 21-specific antibody. The specificity was 100% for both antibodies. The LOD of the real-time PCR method was lower than that of direct sequencing. The mutation specific IHC produced excellent specificity.

  2. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia.

    Directory of Open Access Journals (Sweden)

    Anne L M Vlek

    Full Text Available Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS allows the identification of microorganisms directly from positive blood culture broths. Use of the MALDI-TOF MS for rapid identification of microorganisms from blood culture broths can reduce the turnaround time to identification and may lead to earlier appropriate treatment of bacteremia. During February and April 2010, direct MALDI-TOF MS was routinely performed on all positive blood cultures. During December 2009 and March 2010 no direct MALDI-TOF MS was used. Information on antibiotic therapy was collected from the hospital and intensive care units' information systems from all positive blood cultures during the study period. In total, 253 episodes of bacteremia were included of which 89 during the intervention period and 164 during the control period. Direct performance of MALDI-TOF MS on positive blood culture broths reduced the time till species identification by 28.8-h and was associated with an 11.3% increase in the proportion of patients receiving appropriate antibiotic treatment 24 hours after blood culture positivity (64.0% in the control period versus 75.3% in the intervention period (p0.01. Routine implementation of this technique increased the proportion of patients on adequate antimicrobial treatment within 24 hours.

  3. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia.

    Science.gov (United States)

    Vlek, Anne L M; Bonten, Marc J M; Boel, C H Edwin

    2012-01-01

    Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) allows the identification of microorganisms directly from positive blood culture broths. Use of the MALDI-TOF MS for rapid identification of microorganisms from blood culture broths can reduce the turnaround time to identification and may lead to earlier appropriate treatment of bacteremia. During February and April 2010, direct MALDI-TOF MS was routinely performed on all positive blood cultures. During December 2009 and March 2010 no direct MALDI-TOF MS was used. Information on antibiotic therapy was collected from the hospital and intensive care units' information systems from all positive blood cultures during the study period. In total, 253 episodes of bacteremia were included of which 89 during the intervention period and 164 during the control period. Direct performance of MALDI-TOF MS on positive blood culture broths reduced the time till species identification by 28.8-h and was associated with an 11.3% increase in the proportion of patients receiving appropriate antibiotic treatment 24 hours after blood culture positivity (64.0% in the control period versus 75.3% in the intervention period (p0.01)). Routine implementation of this technique increased the proportion of patients on adequate antimicrobial treatment within 24 hours.

  4. Direct time integration of Maxwell's equations in linear dispersive media with absorption for scattering and propagation of femtosecond electromagnetic pulses

    Science.gov (United States)

    Joseph, Rose M.; Hagness, Susan C.; Taflove, Allen

    1991-01-01

    The initial results for femtosecond pulse propagation and scattering interactions for a Lorentz medium obtained by a direct time integration of Maxwell's equations are reported. The computational approach provides reflection coefficients accurate to better than 6 parts in 10,000 over the frequency range of dc to 3 x 10 to the 16th Hz for a single 0.2-fs Gaussian pulse incident upon a Lorentz-medium half-space. New results for Sommerfeld and Brillouin precursors are shown and compared with previous analyses. The present approach is robust and permits 2D and 3D electromagnetic pulse propagation directly from the full-vector Maxwell's equations.

  5. Standard deviation of wind direction as a function of time; three hours to five hundred seventy-six hours

    International Nuclear Information System (INIS)

    Culkowski, W.M.

    1976-01-01

    The standard deviation of horizontal wind direction sigma/sub theta/ increases with time of averaging up to a maximum value of 104 0 . The average standard deviation of horizontal wind directions averaged over periods of 3, 5, 10, 16, 24, 36, 48, 72, 144, 288, and 576 hours were calculated from wind data obtained from a 100 meter tower in the Oak Ridge area. For periods up to 100 hours, sigma/sub theta/ varies as t/sup .28/; after 100 hours sigma/sub theta/ varies as 6.5 ln t

  6. Direct observation of ultrafast atomic motion using time-resolved X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Shymanovich, U.

    2007-11-13

    This thesis is dedicated to the study of the atomic motion in laser irradiated solids on a picosecond to subpicosecond time-scale using the time-resolved X-ray diffraction technique. In the second chapter, the laser system, the laser-plasma based X-ray source and the experimental setup for optical pump / X-ray probe measurements were presented. Chapter 3 is devoted to the characterization and comparison of different types of X-ray optics. Chapter 4 presented the time-resolved X-ray diffraction experiments performed for this thesis. The first two sections of this chapter discuss the measurements of initially unexpected strain-induced transient changes of the integrated reflectivity of the X-ray probe beam. The elimination of the strain-induced transient changes of the integrated reflectivity represented an important prerequisite to perform the study of lattice heating in Germanium after femtosecond optical excitation by measuring the transient Debye-Waller effect. The third section describes the investigations of acoustic waves upon ultrafast optical excitation and discusses the two different pressure contributions driving them: the thermal and the electronic ones. (orig.)

  7. Direct observation of ultrafast atomic motion using time-resolved X-ray diffraction

    International Nuclear Information System (INIS)

    Shymanovich, U.

    2007-01-01

    This thesis is dedicated to the study of the atomic motion in laser irradiated solids on a picosecond to subpicosecond time-scale using the time-resolved X-ray diffraction technique. In the second chapter, the laser system, the laser-plasma based X-ray source and the experimental setup for optical pump / X-ray probe measurements were presented. Chapter 3 is devoted to the characterization and comparison of different types of X-ray optics. Chapter 4 presented the time-resolved X-ray diffraction experiments performed for this thesis. The first two sections of this chapter discuss the measurements of initially unexpected strain-induced transient changes of the integrated reflectivity of the X-ray probe beam. The elimination of the strain-induced transient changes of the integrated reflectivity represented an important prerequisite to perform the study of lattice heating in Germanium after femtosecond optical excitation by measuring the transient Debye-Waller effect. The third section describes the investigations of acoustic waves upon ultrafast optical excitation and discusses the two different pressure contributions driving them: the thermal and the electronic ones. (orig.)

  8. Has the impact of the working time regulations changed neurosurgical trainees' attitudes towards the European working time directive 5 years on?

    Science.gov (United States)

    Cowie, Christopher J A; Pešić-Smith, Jonathan D; Boukas, Alexandros; Nelson, Richard J

    2013-10-01

    We report the results from a survey of the British Neurosurgical Trainees' Association which aimed to assess current rota patterns and their compliance with the government's working time regulations. The survey questioned whether trainees felt that shift working, imposed as a result of the European working time directive, is continuing to impact on patient care and training opportunities in neurosurgery. The responses to this survey indicate that neurosurgical trainees remain concerned with the impact that the current working time regulations have on all facets of their work: training, work- life balance, and the provision of patient care. The survey comments show that the majority would support a change in legislation to allow greater flexibility in the working time regulations.

  9. A methodology for the stochastic generation of hourly synthetic direct normal irradiation time series

    Science.gov (United States)

    Larrañeta, M.; Moreno-Tejera, S.; Lillo-Bravo, I.; Silva-Pérez, M. A.

    2018-02-01

    Many of the available solar radiation databases only provide global horizontal irradiance (GHI) while there is a growing need of extensive databases of direct normal radiation (DNI) mainly for the development of concentrated solar power and concentrated photovoltaic technologies. In the present work, we propose a methodology for the generation of synthetic DNI hourly data from the hourly average GHI values by dividing the irradiance into a deterministic and stochastic component intending to emulate the dynamics of the solar radiation. The deterministic component is modeled through a simple classical model. The stochastic component is fitted to measured data in order to maintain the consistency of the synthetic data with the state of the sky, generating statistically significant DNI data with a cumulative frequency distribution very similar to the measured data. The adaptation and application of the model to the location of Seville shows significant improvements in terms of frequency distribution over the classical models. The proposed methodology applied to other locations with different climatological characteristics better results than the classical models in terms of frequency distribution reaching a reduction of the 50% in the Finkelstein-Schafer (FS) and Kolmogorov-Smirnov test integral (KSI) statistics.

  10. Intake flow and time step analysis in the modeling of a direct injection Diesel engine

    Energy Technology Data Exchange (ETDEWEB)

    Zancanaro Junior, Flavio V.; Vielmo, Horacio A. [Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Mechanical Engineering Dept.], E-mails: zancanaro@mecanica.ufrgs.br, vielmoh@mecanica.ufrgs.br

    2010-07-01

    This paper discusses the effects of the time step on turbulence flow structure in the intake and in-cylinder systems of a Diesel engine during the intake process, under the motored condition. The three-dimensional modeling of a reciprocating engine geometry comprising a bowl-in-piston combustion chamber, intake port of shallow ramp helical type and exhaust port of conventional type. The equations are numerically solved, including a transient analysis, valves and piston movements, for engine speed of 1500 rpm, using a commercial Finite Volumes CFD code. A parallel computation is employed. For the purpose of examining the in-cylinder turbulence characteristics two parameters are observed: the discharge coefficient and swirl ratio. This two parameters quantify the fluid flow characteristics inside cylinder in the intake stroke, therefore, it is very important their study and understanding. Additionally, the evolution of the discharge coefficient and swirl ratio, along crank angle, are correlated and compared, with the objective of clarifying the physical mechanisms. Regarding the turbulence, computations are performed with the Eddy Viscosity Model k-u SST, in its Low-Reynolds approaches, with standard near wall treatment. The system of partial differential equations to be solved consists of the Reynolds-averaged compressible Navier-Stokes equations with the constitutive relations for an ideal gas, and using a segregated solution algorithm. The enthalpy equation is also solved. A moving hexahedral trimmed mesh independence study is presented. In the same way many convergence tests are performed, and a secure criterion established. The results of the pressure fields are shown in relation to vertical plane that passes through the valves. Areas of low pressure can be seen in the valve curtain region, due to strong jet flows. Also, it is possible to note divergences between the time steps, mainly for the smaller time step. (author)

  11. Decoding face information in time, frequency and space from direct intracranial recordings of the human brain.

    Directory of Open Access Journals (Sweden)

    Naotsugu Tsuchiya

    Full Text Available Faces are processed by a neural system with distributed anatomical components, but the roles of these components remain unclear. A dominant theory of face perception postulates independent representations of invariant aspects of faces (e.g., identity in ventral temporal cortex including the fusiform gyrus, and changeable aspects of faces (e.g., emotion in lateral temporal cortex including the superior temporal sulcus. Here we recorded neuronal activity directly from the cortical surface in 9 neurosurgical subjects undergoing epilepsy monitoring while they viewed static and dynamic facial expressions. Applying novel decoding analyses to the power spectrogram of electrocorticograms (ECoG from over 100 contacts in ventral and lateral temporal cortex, we found better representation of both invariant and changeable aspects of faces in ventral than lateral temporal cortex. Critical information for discriminating faces from geometric patterns was carried by power modulations between 50 to 150 Hz. For both static and dynamic face stimuli, we obtained a higher decoding performance in ventral than lateral temporal cortex. For discriminating fearful from happy expressions, critical information was carried by power modulation between 60-150 Hz and below 30 Hz, and again better decoded in ventral than lateral temporal cortex. Task-relevant attention improved decoding accuracy more than 10% across a wide frequency range in ventral but not at all in lateral temporal cortex. Spatial searchlight decoding showed that decoding performance was highest around the middle fusiform gyrus. Finally, we found that the right hemisphere, in general, showed superior decoding to the left hemisphere. Taken together, our results challenge the dominant model for independent face representation of invariant and changeable aspects: information about both face attributes was better decoded from a single region in the middle fusiform gyrus.

  12. Delivering "Just-In-Time" Smoking Cessation Support Via Mobile Phones: Current Knowledge and Future Directions.

    Science.gov (United States)

    Naughton, Felix

    2016-05-28

    Smoking lapses early on during a quit attempt are highly predictive of failing to quit. A large proportion of these lapses are driven by cravings brought about by situational and environmental cues. Use of cognitive-behavioral lapse prevention strategies to combat cue-induced cravings is associated with a reduced risk of lapse, but evidence is lacking in how these strategies can be effectively promoted. Unlike most traditional methods of delivering behavioral support, mobile phones can in principle deliver automated support, including lapse prevention strategy recommendations, Just-In-Time (JIT) for when a smoker is most vulnerable, and prevent early lapse. JIT support can be activated by smokers themselves (user-triggered), by prespecified rules (server-triggered) or through sensors that dynamically monitor a smoker's context and trigger support when a high risk environment is sensed (context-triggered), also known as a Just-In-Time Adaptive Intervention (JITAI). However, research suggests that user-triggered JIT cessation support is seldom used and existing server-triggered JIT support is likely to lack sufficient accuracy to effectively target high-risk situations in real time. Evaluations of mobile phone cessation interventions that include user and/or server-triggered JIT support have yet to adequately assess whether this improves management of high risk situations. While context-triggered systems have the greatest potential to deliver JIT support, there are, as yet, no impact evaluations of such systems. Although it may soon be feasible to learn about and monitor a smoker's context unobtrusively using their smartphone without burdensome data entry, there are several potential advantages to involving the smoker in data collection. This commentary describes the current knowledge on the potential for mobile phones to deliver automated support to help smokers manage or cope with high risk environments or situations for smoking, known as JIT support. The article

  13. The Timing and Direction of Statutory Tax Rate Changes by the Canadian Provinces

    Directory of Open Access Journals (Sweden)

    Ergete Ferede

    2013-11-01

    Full Text Available Tax rate changes are some of the most significant and far-reaching decisions a government can take. A good understanding of the odds of any such changes is essential for any business debating the timing and location of investments. This paper investigates the factors that affect the timing of statutory tax rate changes by Canadian provincial governments. The authors develop a simple theoretical model to explain the “stickiness” of tax rates — the factors that lead a province to decide against tinkering with the tax system — based on the presence of fixed costs of adjusting tax rates. The results indicate that if the current rate falls within a range of tax rates bracketing the optimal rate, then the government will not adjust its tax rate because the cost of the reform outweighs the potential benefits. To build up a body of evidence, this paper employs a multinomial logit model to examine the likelihood of changes to personal income tax (PIT, corporate income tax (CIT, and provincial sales tax (PST rates by provincial governments over the period 1973-2010. Regression results indicate that provincial governments that start with higher tax rates are more likely to cut, and less likely to raise, their tax rates. A higher provincial budget deficit reduces the probability of a CIT rate cut and raises the probability of a PST rate increase. Party ideology seems to matter. Provinces with leftleaning governments are less likely to cut PIT and PST rates, and more likely to raise PIT rates compared to non-left-leaning governments. The authors also find that a federal PIT rate cut raises the probability of a provincial PIT rate increase, whereas a federal CIT rate cut raises the probability of a provincial CIT rate reduction.

  14. Direct simulation of groundwater transit-time distributions using the reservoir theory

    Science.gov (United States)

    Etcheverry, David; Perrochet, Pierre

    Groundwater transit times are of interest for the management of water resources, assessment of pollution from non-point sources, and quantitative dating of groundwaters by the use of environmental isotopes. The age of water is the time water has spent in an aquifer since it has entered the system, whereas the transit time is the age of water as it exits the system. Water at the outlet of an aquifer is a mixture of water elements with different transit times, as a consequence of the different flow-line lengths. In this paper, transit-time distributions are calculated by coupling two existing methods, the reservoir theory and a recent age-simulation method. Based on the derivation of the cumulative age distribution over the whole domain, the approach accounts for the whole hydrogeological framework. The method is tested using an analytical example and its applicability illustrated for a regional layered aquifer. Results show the asymmetry and multimodality of the transit-time distribution even in advection-only conditions, due to the aquifer geometry and to the velocity-field heterogeneity. Résumé Les temps de transit des eaux souterraines sont intéressants à connaître pour gérer l'évaluation des ressources en eau dans le cas de pollution à partir de sources non ponctuelles, et aussi pour dater quantitativement les eaux souterraines au moyen des isotopes du milieu. L'âge de l'eau est le temps qu'elle a passé dans un aquifère depuis qu'elle est entrée dans le système, alors que le temps de transit est l'âge de l'eau au moment où elle quitte le système. L'eau à la sortie d'un aquifère est un mélange d'eaux possédant différents temps de transit, du fait des longueurs différentes des lignes de courant suivies. Dans ce papier, les distributions des temps de transit sont calculées en couplant deux méthodes, la théorie du réservoir et une méthode récente de simulation des âges. Basée sur la dérivation de la distribution cumulées des âges sur

  15. Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Chernetsova, Elena S; Morlock, Gertrud E

    2011-01-01

    Direct analysis in real time (DART), a relatively new ionization source for mass spectrometry, ionizes small-molecule components from different kinds of samples without any sample preparation and chromatographic separation. The current paper reviews the published data available on the determination of drugs and drug-like compounds in different matrices with DART-MS, including identification and quantitation issues. Parameters that affect ionization efficiency and mass spectra composition are also discussed. Copyright © 2011 Wiley Periodicals, Inc.

  16. Experimental Results for Minimum-Time Trajectory Tracking of a Direct-Drive Three-Link Planar Arm

    Energy Technology Data Exchange (ETDEWEB)

    DRIESSEN,BRIAN; PARKER,GORDON G.

    1999-09-01

    This work is an experimental investigation of the ability of a real three-link direct-drive arm to track model-based minimum-time trajectories that have been found off-line. Sufficiently large velocity gains in the computed torque control law were not achievable with the velocity sensors described herein. This indicates the critical importance of the velocity sensing when attempting to track trajectories that push the envelope of the system's torque capabilities.

  17. Software for real-time localization of baleen whale calls using directional sonobuoys: A case study on Antarctic blue whales.

    Science.gov (United States)

    Miller, Brian S; Calderan, Susannah; Gillespie, Douglas; Weatherup, Graham; Leaper, Russell; Collins, Kym; Double, Michael C

    2016-03-01

    Directional frequency analysis and recording (DIFAR) sonobuoys can allow real-time acoustic localization of baleen whales for underwater tracking and remote sensing, but limited availability of hardware and software has prevented wider usage. These software limitations were addressed by developing a module in the open-source software PAMGuard. A case study is presented demonstrating that this software provides greater efficiency and accessibility than previous methods for detecting, localizing, and tracking Antarctic blue whales in real time. Additionally, this software can easily be extended to track other low and mid frequency sounds including those from other cetaceans, pinnipeds, icebergs, shipping, and seismic airguns.

  18. Separation of time scales in one-dimensional directed nucleation-growth processes

    Science.gov (United States)

    Pierobon, Paolo; Miné-Hattab, Judith; Cappello, Giovanni; Viovy, Jean-Louis; Lagomarsino, Marco Cosentino

    2010-12-01

    Proteins involved in homologous recombination such as RecA and hRad51 polymerize on single- and double-stranded DNA according to a nucleation-growth kinetics, which can be monitored by single-molecule in vitro assays. The basic models currently used to extract biochemical rates rely on ensemble averages and are typically based on an underlying process of bidirectional polymerization, in contrast with the often observed anisotropic polymerization of similar proteins. For these reasons, if one considers single-molecule experiments, the available models are useful to understand observations only in some regimes. In particular, recent experiments have highlighted a steplike polymerization kinetics. The classical model of one-dimensional nucleation growth, the Kolmogorov-Avrami-Mehl-Johnson (KAMJ) model, predicts the correct polymerization kinetics only in some regimes and fails to predict the steplike behavior. This work illustrates by simulations and analytical arguments the limitation of applicability of the KAMJ description and proposes a minimal model for the statistics of the steps based on the so-called stick-breaking stochastic process. We argue that this insight might be useful to extract information on the time and length scales involved in the polymerization kinetics.

  19. Anticipation of direction and time of perturbation modulates the onset latency of trunk muscle responses during sitting perturbations.

    Science.gov (United States)

    Milosevic, Matija; Shinya, Masahiro; Masani, Kei; Patel, Kramay; McConville, Kristiina M V; Nakazawa, Kimitaka; Popovic, Milos R

    2016-02-01

    Trunk muscles are responsible for maintaining trunk stability during sitting. However, the effects of anticipation of perturbation on trunk muscle responses are not well understood. The objectives of this study were to identify the responses of trunk muscles to sudden support surface translations and quantify the effects of anticipation of direction and time of perturbation on the trunk neuromuscular responses. Twelve able-bodied individuals participated in the study. Participants were seated on a kneeling chair and support surface translations were applied in the forward and backward directions with and without direction and time of perturbation cues. The trunk started moving on average approximately 40ms after the perturbation. During unanticipated perturbations, average latencies of the trunk muscle contractions were in the range between 103.4 and 117.4ms. When participants anticipated the perturbations, trunk muscle latencies were reduced by 16.8±10.0ms and the time it took the trunk to reach maximum velocity was also reduced, suggesting a biomechanical advantage caused by faster muscle responses. These results suggested that trunk muscles have medium latency responses and use reflexive mechanisms. Moreover, anticipation of perturbation decreased trunk muscles latencies, suggesting that the central nervous system modulated readiness of the trunk based on anticipatory information. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Saving time and energy with oversubscription and semi-direct Møller-Plesset second order perturbation methods.

    Science.gov (United States)

    Fought, Ellie L; Sundriyal, Vaibhav; Sosonkina, Masha; Windus, Theresa L

    2017-04-30

    In this work, the effect of oversubscription is evaluated, via calling 2n, 3n, or 4n processes for n physical cores, on semi-direct MP2 energy and gradient calculations and RI-MP2 energy calculations with the cc-pVTZ basis using NWChem. Results indicate that on both Intel and AMD platforms, oversubscription reduces total time to solution on average for semi-direct MP2 energy calculations by 25-45% and reduces total energy consumed by the CPU and DRAM on average by 10-15% on the Intel platform. Semi-direct gradient time to solution is shortened on average by 8-15% and energy consumption is decreased by 5-10%. Linear regression analysis shows a strong correlation between time to solution and total energy consumed. Oversubscribing during RI-MP2 calculations results in performance degradations of 30-50% at the 4n level. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  1. In-situ, real-time, studies of film growth processes using ion scattering and direct recoil spectroscopy techniques.

    Energy Technology Data Exchange (ETDEWEB)

    Smentkowski, V. S.

    1999-04-22

    Time-of-flight ion scattering and recoil spectroscopy (TOF-ISARS) enables the characterization of the composition and structure of surfaces with 1-2 monolayer specificity. It will be shown that surface analysis is possible at ambient pressures greater than 3 mTorr using TOF-ISARS techniques; allowing for real-time, in situ studies of film growth processes. TOF-ISARS comprises three analytical techniques: ion scattering spectroscopy (ISS), which detects the backscattered primary ion beam; direct recoil spectroscopy (DRS), which detects the surface species recoiled into the forward scattering direction; and mass spectroscopy of recoiled ions (MSRI), which is 3 variant of DRS capable of isotopic resolution for all surface species--including H and He. The advantages and limitations of each of these techniques will be discussed. The use of the three TOF-ISARS methods for real-time, in situ film growth studies at high ambient pressures will be illustrated. It will be shown that MSRI analysis is possible during sputter deposition. It will be also be demonstrated that the analyzer used for MSRI can also be used for time of flight secondary ion mass spectroscopy (TOF-SIMS) under high vacuum conditions. The use of a single analyzer to perform the complimentary surface analytical techniques of MSRI and SIMS is unique. The dwd functionality of the MSRI analyzer provides surface information not obtained when either MSRI or SIMS is used independently.

  2. Training for the future NHS: training junior doctors in the United Kingdom within the 48-hour European working time directive.

    Science.gov (United States)

    Datta, Shreelatta T; Davies, Sally J

    2014-01-01

    Since August 2009, the National Health Service of the United Kingdom has faced the challenge of delivering training for junior doctors within a 48-hour working week, as stipulated by the European Working Time Directive and legislated in the UK by the Working Time Regulations 1998. Since that time, widespread concern has been expressed about the impact of restricted duty hours on the quality of postgraduate medical training in the UK, particularly in the "craft" specialties--that is, those disciplines in which trainees develop practical skills that are best learned through direct experience with patients. At the same time, specialist training in the UK has experienced considerable change since 2007 with the introduction of competency-based specialty curricula, workplace-based assessment, and the annual review of competency progression. The challenges presented by the reduction of duty hours include increased pressure on doctors-in-training to provide service during evening and overnight hours, reduced interaction with supervisors, and reduced opportunities for learning. This paper explores these challenges and proposes potential responses with respect to the reorganization of training and service provision.

  3. Temperature-dependent release of volatile organic compounds of eucalypts by direct analysis in real time (DART) mass spectrometry.

    Science.gov (United States)

    Maleknia, Simin D; Vail, Teresa M; Cody, Robert B; Sparkman, David O; Bell, Tina L; Adams, Mark A

    2009-08-01

    A method is described for the rapid identification of biogenic, volatile organic compounds (VOCs) emitted by plants, including the analysis of the temperature dependence of those emissions. Direct analysis in real time (DART) enabled ionization of VOCs from stem and leaf of several eucalyptus species including E. cinerea, E. citriodora, E. nicholii and E. sideroxylon. Plant tissues were placed directly in the gap between the DART ionization source skimmer and the capillary inlet of the time-of-flight (TOF) mass spectrometer. Temperature-dependent emission of VOCs was achieved by adjusting the temperature of the helium gas into the DART ionization source at 50, 100, 200 and 300 degrees C, which enabled direct evaporation of compounds, up to the onset of pyrolysis of plant fibres (i.e. cellulose and lignin). Accurate mass measurements facilitated by TOF mass spectrometry provided elemental compositions for the VOCs. A wide range of compounds was detected from simple organic compounds (i.e. methanol and acetone) to a series of monoterpenes (i.e. pinene, camphene, cymene, eucalyptol) common to many plant species, as well as several less abundant sesquiterpenes and flavonoids (i.e. naringenin, spathulenol, eucalyptin) with antioxidant and antimicrobial properties. The leaf and stem tissues for all four eucalypt species showed similar compounds. The relative abundances of methanol and ethanol were greater in stem wood than in leaf tissue suggesting that DART could be used to investigate the tissue-specific transport and emissions of VOCs. Copyright (c) 2009 John Wiley & Sons, Ltd.

  4. Evaluation of the foetal time to death in mice after application of direct and indirect euthanasia methods.

    Science.gov (United States)

    Muñoz-Mediavilla, C; Cámara, J A; Salazar, S; Segui, B; Sanguino, D; Mulero, F; de la Cueva, E; Blanco, I

    2016-04-01

    Directive 2010/63/EU on the protection of animals used for scientific purposes requires that the killing of mammal foetuses during the last third of their gestational period should be accomplished through effective and humane methods. The fact that murine foetuses are resistant to hypoxia-mediated euthanasia renders the current euthanasia methods ineffective or humane for the foetuses when these methods are applied to pregnant female mice. We have assessed the time to death of foetuses after performing either indirect (dam euthanasia) or direct (via intraplacental injection--a new approach to euthanasia) euthanasia methods in order to determine a euthanasia method that is appropriate, ethical and efficient for the killing of mouse foetuses. The respective times to death of foetuses after performing the three most commonly used euthanasia methods (namely cervical dislocation, CO2inhalation and intraperitoneal sodium pentobarbital administration) were recorded. Absence of foetal heartbeat was monitored via ultrasound. We consider that the most effective and humane method of foetal euthanasia was the one able to achieve foetal death within the shortest possible period of time. Among the indirect euthanasia methods assessed, the administration of a sodium pentobarbital overdose to pregnant female mice was found to be the fastest for foetuses, with an average post-treatment foetal death of approximately 29.8 min. As for the direct euthanasia method assessed, foetal time to death after intraplacental injection of sodium pentobarbital was approximately 14 min. Significant differences among the different mouse strains employed were found. Based on the results obtained in our study, we consider that the administration of a sodium pentobarbital overdose by intraplacental injection to be an effective euthanasia method for murine foetuses. © The Author(s) 2015.

  5. An experimentally verified model for estimating the distance resolution capability of direct time of flight 3D optical imaging systems

    International Nuclear Information System (INIS)

    Nguyen, K Q K; Fisher, E M D; Walton, A J; Underwood, I

    2013-01-01

    This report introduces a new statistical model for time-resolved photon detection in a generic single-photon-sensitive sensor array. The model is validated by comparing modelled data with experimental data collected on a single-photon avalanche diode sensor array. Data produced by the model are used alongside corresponding experimental data to calculate, for the first time, the effective distance resolution of a pulsed direct time of flight 3D optical imaging system over a range of conditions using four peak-detection algorithms. The relative performance of the algorithms is compared. The model can be used to improve the system design process and inform selection of the optimal peak-detection algorithm. (paper)

  6. Barriers to Real-Time Medical Direction via Cellular Communication for Prehospital Emergency Care Providers in Gujarat, India.

    Science.gov (United States)

    Lindquist, Benjamin; Strehlow, Matthew C; Rao, G V Ramana; Newberry, Jennifer A

    2016-07-08

    Many low- and middle-income countries depend on emergency medical technicians (EMTs), nurses, midwives, and layperson community health workers with limited training to provide a majority of emergency medical, trauma, and obstetric care in the prehospital setting. To improve timely patient care and expand provider scope of practice, nations leverage cellular phones and call centers for real-time online medical direction. However, there exist several barriers to adequate communication that impact the provision of emergency care. We sought to identify obstacles in the cellular communication process among GVK Emergency Management and Research Institute (GVK EMRI) EMTs in Gujarat, India. A convenience sample of practicing EMTs in Gujarat, India were surveyed regarding the barriers to call initiation and completion. 108 EMTs completed the survey. Overall, ninety-seven (89.8%) EMTs responded that the most common reason they did not initiate a call with the call center physician was insufficient time. Forty-six (42%) EMTs reported that they were unable to call the physician one or more times during a typical workweek (approximately 5-6 twelve-hour shifts/week) due to their hands being occupied performing direct patient care. Fifty-eight (54%) EMTs reported that they were unable to reach the call center physician, despite attempts, at least once a week. This study identified multiple barriers to communication, including insufficient time to call for advice and inability to reach call center physicians. Identification of simple interventions and best practices may improve communication and ensure timely and appropriate prehospital care.

  7. Real-time direct cell concentration and viability determination using a fully automated microfluidic platform for standalone process monitoring

    DEFF Research Database (Denmark)

    Rodrigues de Sousa Nunes, Pedro André; Kjaerulff, S.; Dufva, Martin

    2015-01-01

    system performance by monitoring in real time the cell concentration and viability of yeast extracted directly from an in-house made bioreactor. This is the first demonstration of using the Dean drag force, generated due to the implementation of a curved microchannel geometry in conjunction with high...... flow rates, to promote passive mixing of cell samples and thus homogenization of the diluted cell plug. The autonomous operation of the fluidics furthermore allows implementation of intelligent protocols for administering air bubbles from the bioreactor in the microfluidic system, so...... and thereby ensure optimal cell production, by prolonging the fermentation cycle and increasing the bioreactor output. In this work, we report on the development of a fully automated microfluidic system capable of extracting samples directly from a bioreactor, diluting the sample, staining the cells...

  8. A mathematical model for the control of carrier-dependent infectious diseases with direct transmission and time delay

    International Nuclear Information System (INIS)

    Misra, A.K.; Mishra, S.N.; Pathak, A.L.; Srivastava, P.K.; Chandra, Peeyush

    2013-01-01

    In this paper, a non-linear delay mathematical model for the control of carrier-dependent infectious diseases through insecticides is proposed and analyzed. In the modeling process, it is assumed that disease spreads due to direct contact between susceptibles and infectives as well as through carriers (indirect contact). Further, it is assumed that insecticides are used to kill carriers and the rate of introduction of insecticides is proportional to the density of carriers with some time lag. The model analysis suggests that as delay in using insecticides exceeds some critical value, the system loses its stability and Hopf-bifurcation occurs. The direction, stability and period of the bifurcating periodic solutions arising through Hopf-bifurcation are also analyzed using normal form concept and center manifold theory. Numerical simulation is carried out to confirm the obtained analytical results

  9. A direct indication of plasma potential diagnostic with fast time response and high accuracy based on a differential emissive probe

    International Nuclear Information System (INIS)

    Yao, W.E.; Hershkowitz; Intrator, T.

    1985-01-01

    The floating potential of the emissive probe has been used to directly measure the plasma potential. The authors have recently presented another method for directly indicating the plasma potential with a differential emissive probe. In this paper they describe the effects of probe size, plasma density and plasma potential fluctuation on plasma potential measurements and give methods for reducing errors. A control system with fast time response (α 20 μs) and high accuracy (the order of the probe temperature T/sub w//e) for maintaining a differential emissive probe at plasma potential has been developed. It can be operated in pulsed discharge plasma to measure plasma potential dynamic characteristics. A solid state optical coupler is employed to improve circuit performance. This system was tested experimentally by measuring the plasma potential in an argon plasma device an on the Phaedrus tandem mirror

  10. A direct indication of plasma potential diagnostic with fast time response and high accuracy based on a differential emissive probe

    International Nuclear Information System (INIS)

    Yao, W.E.; Hershkowitz, N.; Intrator, T.

    1985-01-01

    The floating potential of the emissive probe has been used to directly measure the plasma potential. The authors have recently presented another method for directly indicating the plasma potential with a differential emissive probe. In this paper they describe the effects of probe size, plasma density and plasma potential fluctuation on plasma potential measurements and give methods for reducing errors. A control system with fast time response (≅ 20 μs) and high accuracy (the order of the probe temperature T/sub w//e) for maintaining a differential emissive probe at plasma potential has been developed. It can be operated in pulsed discharge plasma to measure plasma potential dynamic characteristics. A solid state optical coupler is employed to improve circuit performance. This system was tested experimentally by measuring the plasma potential in an argon plasma device and on the Phaedrus tandem mirror

  11. Finding NEMO (novel electromaterial muscle oscillator): a polypyrrole powered robotic fish with real-time wireless speed and directional control

    International Nuclear Information System (INIS)

    McGovern, Scott; Alici, Gursel; Spinks, Geoffrey; Truong, Van-Tan

    2009-01-01

    This paper presents the development of an autonomously powered and controlled robotic fish that incorporates an active flexural joint tail fin, activated through conducting polymer actuators based on polypyrrole (PPy). The novel electromaterial muscle oscillator (NEMO) tail fin assembly on the fish could be controlled wirelessly in real time by varying the frequency and duty cycle of the voltage signal supplied to the PPy bending-type actuators. Directional control was achieved by altering the duty cycle of the voltage input to the NEMO tail fin, which shifted the axis of oscillation and enabled turning of the robotic fish. At low speeds, the robotic fish had a turning circle as small as 15 cm (or 1.1 body lengths) in radius. The highest speed of the fish robot was estimated to be approximately 33 mm s −1 (or 0.25 body lengths s −1 ) and was achieved with a flapping frequency of 0.6–0.8 Hz which also corresponded with the most hydrodynamically efficient mode for tail fin operation. This speed is approximately ten times faster than those for any previously reported artificial muscle based device that also offers real-time speed and directional control. This study contributes to previously published studies on bio-inspired functional devices, demonstrating that electroactive polymer actuators can be real alternatives to conventional means of actuation such as electric motors

  12. Finding NEMO (novel electromaterial muscle oscillator): a polypyrrole powered robotic fish with real-time wireless speed and directional control

    Science.gov (United States)

    McGovern, Scott; Alici, Gursel; Truong, Van-Tan; Spinks, Geoffrey

    2009-09-01

    This paper presents the development of an autonomously powered and controlled robotic fish that incorporates an active flexural joint tail fin, activated through conducting polymer actuators based on polypyrrole (PPy). The novel electromaterial muscle oscillator (NEMO) tail fin assembly on the fish could be controlled wirelessly in real time by varying the frequency and duty cycle of the voltage signal supplied to the PPy bending-type actuators. Directional control was achieved by altering the duty cycle of the voltage input to the NEMO tail fin, which shifted the axis of oscillation and enabled turning of the robotic fish. At low speeds, the robotic fish had a turning circle as small as 15 cm (or 1.1 body lengths) in radius. The highest speed of the fish robot was estimated to be approximately 33 mm s-1 (or 0.25 body lengths s-1) and was achieved with a flapping frequency of 0.6-0.8 Hz which also corresponded with the most hydrodynamically efficient mode for tail fin operation. This speed is approximately ten times faster than those for any previously reported artificial muscle based device that also offers real-time speed and directional control. This study contributes to previously published studies on bio-inspired functional devices, demonstrating that electroactive polymer actuators can be real alternatives to conventional means of actuation such as electric motors.

  13. Micromachined silicon acoustic delay line with improved structural stability and acoustic directivity for real-time photoacoustic tomography

    Science.gov (United States)

    Cho, Young; Kumar, Akhil; Xu, Song; Zou, Jun

    2017-03-01

    Recent studies have shown that micromachined silicon acoustic delay lines can provide a promising solution to achieve real-time photoacoustic tomography without the need for complex transducer arrays and data acquisition electronics. However, as its length increases to provide longer delay time, the delay line becomes more vulnerable to structural instability due to reduced mechanical stiffness. In addition, the small cross-section area of the delay line results in a large acoustic acceptance angle and therefore poor directivity. To address these two issues, this paper reports the design, fabrication, and testing of a new silicon acoustic delay line enhanced with 3D printed polymer micro linker structures. First, mechanical deformation of the silicon acoustic delay line (with and without linker structures) under gravity was simulated by using finite element method. Second, the acoustic crosstalk and acoustic attenuation caused by the polymer micro linker structures were evaluated with both numerical simulation and ultrasound transmission testing. The result shows that the use of the polymer micro linker structures significantly improves the structural stability of the silicon acoustic delay lines without creating additional acoustic attenuation and crosstalk. In addition, a new tapered design for the input terminal of the delay line was also investigate to improve its acoustic directivity by reducing the acoustic acceptance angle. These two improvements are expected to provide an effective solution to eliminate current limitations on the achievable acoustic delay time and out-of-plane imaging resolution of micromachined silicon acoustic delay line arrays.

  14. Rapid analysis of Δ-9-tetrahydrocannabinol in hair using direct analysis in real time ambient ionization orbitrap mass spectrometry.

    Science.gov (United States)

    Duvivier, Wilco F; van Beek, Teris A; Pennings, Ed J M; Nielen, Michel W F

    2014-04-15

    Forensic hair analysis methods are laborious, time-consuming and provide only a rough retrospective estimate of the time of drug intake. Recently, hair imaging methods using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) were reported, but these methods require the application of MALDI matrix and are performed under vacuum. Direct analysis of entire locks of hair without any sample pretreatment and with improved spatial resolution would thus address a need. Hair samples were attached to stainless steel mesh screens and scanned in the X-direction using direct analysis in real time (DART) ambient ionization orbitrap MS. The DART gas temperature and the accuracy of the probed hair zone were optimized using Δ-9-tetrahydrocannabinol (THC) as a model compound. Since external contamination is a major issue in forensic hair analysis, sub-samples were measured before and after dichloromethane decontamination. The relative intensity of the THC signal in spiked blank hair versus that of quinine as the internal standard showed good reproducibility (26% RSD) and linearity of the method (R(2)  = 0.991). With the DART hair scan THC could be detected in hair samples from different chronic cannabis users. The presence of THC was confirmed by quantitative liquid chromatography/tandem mass spectrometry. Zones with different THC content could be clearly distinguished, indicating that the method might be used for retrospective timeline assessments. Detection of THC in decontaminated drug user hair showed that the DART hair scan not only probes THC on the surface of hair, but penetrates deeply enough to measure incorporated THC. A new approach in forensic hair analysis has been developed by probing complete locks of hair using DART-MS. Longitudinal scanning enables detection of incorporated compounds and can be used as pre-screening for THC without sample preparation. The method could also be adjusted for the analysis of other drugs of abuse. Copyright

  15. An analysis of periodic solutions of bi-directional associative memory networks with time-varying delays

    International Nuclear Information System (INIS)

    Cao Jinde; Jiang Qiuhao

    2004-01-01

    In this Letter, several sufficient conditions are derived for the existence and uniqueness of periodic oscillatory solution for bi-directional associative memory (BAM) networks with time-varying delays by employing a new Lyapunov functional and an elementary inequality, and all other solutions of the BAM networks converge exponentially to the unique periodic solution. These criteria are presented in terms of system parameters and have important leading significance in the design and applications of periodic neural circuits for delayed BAM. As an illustration, two numerical examples are worked out using the results obtained

  16. Time-dependent wave-packet study of the direct low-energy dissociative recombination of HD+

    International Nuclear Information System (INIS)

    Orel, A. E.

    2000-01-01

    Wave-packet methods involving the numerical solution of the time-dependent Schroedinger equation have been used with great success in the calculation of cross sections for dissociative recombination of molecular ions by electron impact in the high energy region where the ''boomerang'' model [L. Dube and A. Herzenberg, Phys. Rev. A 11, 1314 (1975)] is valid. We extend this method to study low-energy dissociative recombination where this approximation is no longer appropriate. We apply the method to the ''direct'' low-energy dissociative recombination of HD + . Our results are in excellent agreement with calculations using the multichannel quantum defect method. (c) 2000 The American Physical Society

  17. Alternating-direction implicit numerical solution of the time-dependent, three-dimensional, single fluid, resistive magnetohydrodynamic equations

    Energy Technology Data Exchange (ETDEWEB)

    Finan, C.H. III

    1980-12-01

    Resistive magnetohydrodynamics (MHD) is described by a set of eight coupled, nonlinear, three-dimensional, time-dependent, partial differential equations. A computer code, IMP (Implicit MHD Program), has been developed to solve these equations numerically by the method of finite differences on an Eulerian mesh. In this model, the equations are expressed in orthogonal curvilinear coordinates, making the code applicable to a variety of coordinate systems. The Douglas-Gunn algorithm for Alternating-Direction Implicit (ADI) temporal advancement is used to avoid the limitations in timestep size imposed by explicit methods. The equations are solved simultaneously to avoid syncronization errors.

  18. REGIONAL DIFFERENCES IN THE AMOUNTS OF SINGLE AREA PAYMENT SCHEME IN AGRICULTURE

    Directory of Open Access Journals (Sweden)

    Hanna Teszbir

    2014-09-01

    Full Text Available The article discusses the causes of regional variation in the direct payments. The publication data has been used from ARiMR, publications which spans the time included the amount of subsidies paid throughout the post-accession period. Both at national and regional level, the total amount of payments increased from year to year, average 10%, which was connected to the principle phasing in. The amount of aid received by individual regions and individual farms varied widely, which had a direct relationship with the agrarian structure and the average total area of farms in these areas. The bigger number of small farms, as well as the smaller average total surface area of a single voivodeship, the lower sum of the payments.

  19. Real-time measurement of plutonium in air by direct-inlet surface ionization mass spectrometry. Status report

    International Nuclear Information System (INIS)

    Stoffels, J.J.

    1980-04-01

    A new technique is being developed for monitoring low-level airborne plutonium on a real-time basis. The technique is based on surface ionization mass spectrometry of airborne particles. It will be capable of measuring plutonium concentrations below the maximum permissible concentration (MPC) level. A complete mass spectrometer was designed and constructed for this purpose. Major components which were developed and made operational for the instrument include an efficient inlet for directly sampling particles in air, a wide dynamic range ion detector and a minicomputer-based ion-burst measurement system. Calibration of the direct-inlet mass spectrometer (DIMS) was initiated to establish the instrument's response to plutonium dioxide as a function of concentration and particle size. This work revealed an important problem - bouncing of particles upon impact with the ionizing filament. Particle bounce results in a significant loss of measurement sensitivity. The feasibility of using an oven ionizer to overcome the particle bounce problem has been demonstrated. A rhenium oven ionizer was designed and constructed for the purpose of trapping particles which enter via the direct inlet. High-speed particles were trapped in the oven yielding a measurement sensitivity comparable to that for particles which are preloaded. Development of the Pu DIMS can now be completed by optimizing the oven design and calibrating the instrument's performance with UO 2 and CeO 2 particles as analogs to PuO 2 particles

  20. Direct mass measurements in the light neutron-rich region using a combined energy and time-of-flight technique

    International Nuclear Information System (INIS)

    Pillai, C.; Swenson, L.W.; Vieira, D.J.; Butler, G.W.; Wouters, J.M.; Rokni, S.H.; Vaziri, K.; Remsberg, L.P.

    1985-01-01

    This experiment has demonstrated that direct mass measurements can be performed (albeit of low precision in this first attempt) using the M proportional to ET 2 method. This technique has the advantage that many particle-bound nuclei, produced in fragmentation reactions can be measured simultaneously, independent of their N or Z. The main disadvantage of this approach is that both energy and time-of-flight must be measured precisely on an absolute scale. Although some mass walk with N and Z was observed in this experiment, these uncertainties were largely removed by extrapolating the smooth dependence observed for known nuclei which lie closer to the valley of β-stability. Mass measurements for several neutron-rich light nuclei ranging from 17 C to 26 Ne have been performed. In all cases these measurements agree with the latest mass compilation of Wapstra and Audi. The masses of 20 N and 24 F have been determined for the first time

  1. First Direct Mass Measurements of Nuclides around Z =100 with a Multireflection Time-of-Flight Mass Spectrograph

    Science.gov (United States)

    Ito, Y.; Schury, P.; Wada, M.; Arai, F.; Haba, H.; Hirayama, Y.; Ishizawa, S.; Kaji, D.; Kimura, S.; Koura, H.; MacCormick, M.; Miyatake, H.; Moon, J. Y.; Morimoto, K.; Morita, K.; Mukai, M.; Murray, I.; Niwase, T.; Okada, K.; Ozawa, A.; Rosenbusch, M.; Takamine, A.; Tanaka, T.; Watanabe, Y. X.; Wollnik, H.; Yamaki, S.

    2018-04-01

    The masses of 246Es, 251Fm, and the transfermium nuclei Md-252249 and 254No, produced by hot- and cold-fusion reactions, in the vicinity of the deformed N =152 neutron shell closure, have been directly measured using a multireflection time-of-flight mass spectrograph. The masses of 246Es and 249,250,252Md were measured for the first time. Using the masses of Md,250249 as anchor points for α decay chains, the masses of heavier nuclei, up to 261Bh and 266Mt, were determined. These new masses were compared with theoretical global mass models and demonstrated to be in good agreement with macroscopic-microscopic models in this region. The empirical shell gap parameter δ2 n derived from three isotopic masses was updated with the new masses and corroborates the existence of the deformed N =152 neutron shell closure for Md and Lr.

  2. Inferring Weighted Directed Association Networks from Multivariate Time Series with the Small-Shuffle Symbolic Transfer Entropy Spectrum Method

    Directory of Open Access Journals (Sweden)

    Yanzhu Hu

    2016-09-01

    Full Text Available Complex network methodology is very useful for complex system exploration. However, the relationships among variables in complex systems are usually not clear. Therefore, inferring association networks among variables from their observed data has been a popular research topic. We propose a method, named small-shuffle symbolic transfer entropy spectrum (SSSTES, for inferring association networks from multivariate time series. The method can solve four problems for inferring association networks, i.e., strong correlation identification, correlation quantification, direction identification and temporal relation identification. The method can be divided into four layers. The first layer is the so-called data layer. Data input and processing are the things to do in this layer. In the second layer, we symbolize the model data, original data and shuffled data, from the previous layer and calculate circularly transfer entropy with different time lags for each pair of time series variables. Thirdly, we compose transfer entropy spectrums for pairwise time series with the previous layer’s output, a list of transfer entropy matrix. We also identify the correlation level between variables in this layer. In the last layer, we build a weighted adjacency matrix, the value of each entry representing the correlation level between pairwise variables, and then get the weighted directed association network. Three sets of numerical simulated data from a linear system, a nonlinear system and a coupled Rossler system are used to show how the proposed approach works. Finally, we apply SSSTES to a real industrial system and get a better result than with two other methods.

  3. Statistical characteristic in time-domain of direct current corona-generated audible noise from conductor in corona cage

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xuebao, E-mail: lxb08357x@ncepu.edu.cn; Cui, Xiang, E-mail: x.cui@ncepu.edu.cn; Ma, Wenzuo; Bian, Xingming; Wang, Donglai [State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources, North China Electric Power University, Beijing 102206 (China); Lu, Tiebing, E-mail: tiebinglu@ncepu.edu.cn [Beijing Key Laboratory of High Voltage and EMC, North China Electric Power University, Beijing 102206 (China); Hiziroglu, Huseyin [Department of Electrical and Computer Engineering, Kettering University, Flint, Michigan 48504 (United States)

    2016-03-15

    The corona-generated audible noise (AN) has become one of decisive factors in the design of high voltage direct current (HVDC) transmission lines. The AN from transmission lines can be attributed to sound pressure pulses which are generated by the multiple corona sources formed on the conductor, i.e., transmission lines. In this paper, a detailed time-domain characteristics of the sound pressure pulses, which are generated by the DC corona discharges formed over the surfaces of a stranded conductors, are investigated systematically in a laboratory settings using a corona cage structure. The amplitude of sound pressure pulse and its time intervals are extracted by observing a direct correlation between corona current pulses and corona-generated sound pressure pulses. Based on the statistical characteristics, a stochastic model is presented for simulating the sound pressure pulses due to DC corona discharges occurring on conductors. The proposed stochastic model is validated by comparing the calculated and measured A-weighted sound pressure level (SPL). The proposed model is then used to analyze the influence of the pulse amplitudes and pulse rate on the SPL. Furthermore, a mathematical relationship is found between the SPL and conductor diameter, electric field, and radial distance.

  4. A New Real Time Lyapunov Based Controller for Power Quality Improvement in Unified Power Flow Controllers Using Direct Matrix Converters

    Directory of Open Access Journals (Sweden)

    Joaquim Monteiro

    2017-06-01

    Full Text Available This paper proposes a Direct Matrix Converter operating as a Unified Power Flow Controller (DMC-UPFC with an advanced control method for UPFC, based on the Lyapunov direct method, presenting good results in power quality assessment. This control method is used for real-time calculation of the appropriate matrix switching state, determining which switching state should be applied in the following sampling period. The control strategy takes into account active and reactive power flow references to choose the vector converter closest to the optimum. Theoretical principles for this new real-time vector modulation and control applied to the DMC-UPFC with input filter are established. The method needs DMC-UPFC dynamic equations to be solved just once in each control cycle, to find the required optimum vector, in contrast to similar control methods that need 27 vector estimations per control cycle. The designed controller’s performance was evaluated using Matlab/Simulink software. Controllers were also implemented using a digital signal processing (DSP system and matrix hardware. Simulation and experimental results show decoupled transmission line active (P and reactive (Q power control with zero theoretical error tracking and fast response. Output currents and voltages show small ripple and low harmonic content.

  5. Rapid determination of ginkgolic acids in Ginkgo biloba kernels and leaves by direct analysis in real time-mass spectrometry.

    Science.gov (United States)

    Huang, Zhongping; Xu, Yueting; Huang, Yilei; Liu, Charles; Jiang, Kezhi; Wang, Lili

    2017-12-01

    A novel method based on direct analysis in real time integrated with mass spectrometry was established and applied into rapid determination of ginkgolic acids in Ginkgo biloba kernels and leaves. Instrument parameter settings were optimized to obtain the sensitive and accurate determination of ginkgolic acids. At the sample introduction speed of 0.2 mm/s, high intensity of [M-H] - ions for ginkgolic acids were observed in the negative ion mode by utilization of high-purity helium gas at 450°C. Two microliters of methanol extract of G. biloba kernels or leaves dropped on the surface of Quick-Strip module was analyzed after solvent evaporated to dryness. A series of standard solutions of ginkgolic acid 13:0 in the range of 2-50 mg/L were analyzed with a correlation coefficient r = 0.9981 and relative standard deviation (n = 5) from 12.5 to 13.7%. The limit of detection was 0.5 mg/L. The results of direct analysis in real time-mass spectrometry were in agreement with those observed by thermochemolysis gas chromatography. The proposed method demonstrated significant potential in the application of the high-throughput screening and rapid analysis for ginkgolic acids in dietary supplements. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Direct Analysis in Real Time Mass Spectrometry for the Nondestructive Investigation of Conservation Treatments of Cultural Heritage

    Directory of Open Access Journals (Sweden)

    Marcello Manfredi

    2016-01-01

    Full Text Available Today the long-term conservation of cultural heritage is a big challenge: often the artworks were subjected to unknown interventions, which eventually were found to be harmful. The noninvasive investigation of the conservation treatments to which they were subjected to is a crucial step in order to undertake the best conservation strategies. We describe here the preliminary results on a quick and direct method for the nondestructive identification of the various interventions of parchment by means of direct analysis in real time (DART ionization and high-resolution time-of-flight mass spectrometry and chemometrics. The method has been developed for the noninvasive analysis of the Dead Sea Scrolls, one of the most important archaeological discoveries of the 20th century. In this study castor oil and glycerol parchment treatments, prepared on new parchment specimens, were investigated in order to evaluate two different types of operations. The method was able to identify both treatments. In order to investigate the effect of the ion source temperature on the mass spectra, the DART-MS analysis was also carried out at several temperatures. Due to the high sensitivity, simplicity, and no sample preparation requirement, the proposed analytical methodology could help conservators in the challenging analysis of unknown treatments in cultural heritage.

  7. Statistical characteristic in time-domain of direct current corona-generated audible noise from conductor in corona cage

    Science.gov (United States)

    Li, Xuebao; Cui, Xiang; Lu, Tiebing; Ma, Wenzuo; Bian, Xingming; Wang, Donglai; Hiziroglu, Huseyin

    2016-03-01

    The corona-generated audible noise (AN) has become one of decisive factors in the design of high voltage direct current (HVDC) transmission lines. The AN from transmission lines can be attributed to sound pressure pulses which are generated by the multiple corona sources formed on the conductor, i.e., transmission lines. In this paper, a detailed time-domain characteristics of the sound pressure pulses, which are generated by the DC corona discharges formed over the surfaces of a stranded conductors, are investigated systematically in a laboratory settings using a corona cage structure. The amplitude of sound pressure pulse and its time intervals are extracted by observing a direct correlation between corona current pulses and corona-generated sound pressure pulses. Based on the statistical characteristics, a stochastic model is presented for simulating the sound pressure pulses due to DC corona discharges occurring on conductors. The proposed stochastic model is validated by comparing the calculated and measured A-weighted sound pressure level (SPL). The proposed model is then used to analyze the influence of the pulse amplitudes and pulse rate on the SPL. Furthermore, a mathematical relationship is found between the SPL and conductor diameter, electric field, and radial distance.

  8. Microorganisms direct identification from blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

    Science.gov (United States)

    Ferreira, L; Sánchez-Juanes, F; Porras-Guerra, I; García-García, M I; García-Sánchez, J E; González-Buitrago, J M; Muñoz-Bellido, J L

    2011-04-01

    Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) allows a fast and reliable bacterial identification from culture plates. Direct analysis of clinical samples may increase its usefulness in samples in which a fast identification of microorganisms can guide empirical treatment, such as blood cultures (BC). Three hundred and thirty BC, reported as positive by the automated BC incubation device, were processed by conventional methods for BC processing, and by a fast method based on direct MALDI-TOF MS. Three hundred and eighteen of them yield growth on culture plates, and 12 were false positive. The MALDI-TOF MS-based method reported that no peaks were found, or the absence of a reliable identification profile, in all these false positive BC. No mixed cultures were found. Among these 318 BC, we isolated 61 Gram-negatives (GN), 239 Gram-positives (GP) and 18 fungi. Microorganism identifications in GN were coincident with conventional identification, at the species level, in 83.3% of BC and, at the genus level, in 96.6%. In GP, identifications were coincident with conventional identification in 31.8% of BC at the species level, and in 64.8% at the genus level. Fungaemia was not reliably detected by MALDI-TOF. In 18 BC positive for Candida species (eight C. albicans, nine C. parapsilosis and one C. tropicalis), no microorganisms were identified at the species level, and only one (5.6%) was detected at the genus level. The results of the present study show that this fast, MALDI-TOF MS-based method allows bacterial identification directly from presumptively positive BC in a short time (<30 min), with a high accuracy, especially when GN bacteria are involved. © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.

  9. The use of direct analysis in real time (DART) to assess the levels of inhibitors co-extracted with DNA and the associated impact in quantification and amplification.

    Science.gov (United States)

    Moreno, Lilliana I; McCord, Bruce R

    2016-10-01

    The measure of quality in DNA sample processing starts with an effective nucleic acid isolation procedure. Most problems with DNA sample typing can be attributed to low quantity DNA and/or to the presence of inhibitors in the sample. Therefore, establishing which isolation method is best at removing potential inhibitors may help overcome some of the problems analysts encounter by providing useful information in the determination of the optimal approach for any given sample. Direct analysis in real time (DART) mass spectrometry was used in this study to investigate the ability of different extraction methods to remove PCR inhibitors. Methods investigated included both liquid/liquid (phenol-chloroform) and solid phase based robotic procedures, (PrepFiler™ and EZ1 chemistries). Following extraction, samples were analyzed by DART in order to determine the level of remaining inhibitors and then quantified and amplified to determine the effect any remaining inhibitor had on the overall results. The data suggests that organic extraction methods result in detrimental amounts of phenol carryover while automated methods may produce carry-over of bile salts and other chemicals that preferentially bind the solid phase matrix. Both of these effects can have a negative impact in downstream sample processing and genotyping by PCR. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Direct Time Domain Numerical Analysis of Transient Behavior of a VLFS during Unsteady External Loads in Wave Condition

    Directory of Open Access Journals (Sweden)

    Yong Cheng

    2014-01-01

    Full Text Available The transient response of the VLFS subjected to arbitrary external load is systematically investigated by a direct time domain modal expansion method, in which the BEM solutions based on time domain Kelvin sources are used for hydrodynamic forces. In the analysis, the time domain free-surface Green functions with sufficient accuracy are rapidly evaluated in finite water depth by the interpolation-tabulation method, and the boundary integral equation with a quarter VLFS model is established taking advantage of symmetry of flow field and structure. The validity of the present method is verified by comparing with the time histories of vertical displacements of the VLFS during a mass drop and airplane landing and takeoff in still water conditions, respectively. Then the developed numerical scheme is used in wave conditions to study the combined action taking into account the mass drop/airplane landing/takeoff loads as well as incident wave action. It is found that the elevation of structural waves due to mass drop load can be significantly changed near the impact region, while the vertical motion of runway in wave conditions is dominant as compared with that only generated by airplane.

  11. Theoretical quantification of shock-timing sensitivities for direct-drive inertial confinement fusion implosions on OMEGA

    Science.gov (United States)

    Cao, D.; Boehly, T. R.; Gregor, M. C.; Polsin, D. N.; Davis, A. K.; Radha, P. B.; Regan, S. P.; Goncharov, V. N.

    2018-05-01

    Using temporally shaped laser pulses, multiple shocks can be launched in direct-drive inertial confinement fusion implosion experiments to set the shell on a desired isentrope or adiabat. The velocity of the first shock and the times at which subsequent shocks catch up to it are measured through the velocity interferometry system for any reflector diagnostic [T. R. Boehly et al., Phys. Plasmas 18, 092706 (2011)] on OMEGA [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)]. Simulations reproduce these velocity and shock-merger time measurements when using laser pulses designed for setting mid-adiabat (α ˜ 3) implosions, but agreement degrades for lower-adiabat (α ˜ 1) designs. Simulation results indicate that the shock timing discrepancy is most sensitive to details of the density and temperature profiles in the coronal plasma, which influences the laser energy coupled into the target, and only marginally sensitive to the target offset and beam power imbalance. To aid in verifying the coronal profile's influence, a new technique under development to infer coronal profiles using x-ray self-emission imaging [A. K. Davis et al., Bull. Am. Phys. Soc. 61, BAPS.2016.DPP.NO8.7 (2016)] can be applied to the pulse shapes used in shock-timing experiments.

  12. Path integration of head direction: updating a packet of neural activity at the correct speed using neuronal time constants.

    Science.gov (United States)

    Walters, D M; Stringer, S M

    2010-07-01

    A key question in understanding the neural basis of path integration is how individual, spatially responsive, neurons may self-organize into networks that can, through learning, integrate velocity signals to update a continuous representation of location within an environment. It is of vital importance that this internal representation of position is updated at the correct speed, and in real time, to accurately reflect the motion of the animal. In this article, we present a biologically plausible model of velocity path integration of head direction that can solve this problem using neuronal time constants to effect natural time delays, over which associations can be learned through associative Hebbian learning rules. The model comprises a linked continuous attractor network and competitive network. In simulation, we show that the same model is able to learn two different speeds of rotation when implemented with two different values for the time constant, and without the need to alter any other model parameters. The proposed model could be extended to path integration of place in the environment, and path integration of spatial view.

  13. EFFECTS OF POLISHING TIME AND THERMALCYCLINGON THE MICROLEAKAGE OF FOUR TOOTH –COLOURED DIRECT RESTORATIVE MATERIALS

    Directory of Open Access Journals (Sweden)

    V MORTAZAVI

    2002-09-01

    Full Text Available Introdaction. Microleakage has been recognized as a major clinical problem with direct filled dental restorations.The purpose of this study was to investigate and to compare the microleakage of four direct filled tooth-coloured materials, evaluation the effects of polishing time and thermocycling on the microleakage of these materials. Methods. Wedge-shaped class V cavities were prepared on buccal and lingual surfaces of 96 intact extracted human molar teeth. The teeth were randomly divided into three treatment groups and four subgroups. The cavities of each subgroup were filled using one of these materials: a conventional glass ionomer; a resin modified glass ionomer; a composite resin and a compomer. Polishing in the teeth of group 1 was done immediately after placement of restorations and in group 2 one week later. In group 3 delayed polishing and thermocycling (X100 was done. All of the teeth were stored in distilled water for one week and then stained with dye, sectioned, and scored for microleakage on occlusal and cervical edges. Results were statistically analyzed by Kruskal wallis and Mann whitney tests. Results. There was a statistically difference between the microleakage scores of four materials (P < 0.001. Immediately polished glass ionomer and compomer groups have significantly more microleakage than delayed polished groups (P < 0.001. Thermocycting could infulence the microleakage of composite on cervical edges (P < 0.05. Discussion. The precense of differences between the nature of materials and also the surface treatment such as primer or etchant application could influence the microleakage. The prescence of differences in reaction rate between the materials and the time that they reach to their adequate mechanical strength and adhesive bond strength lead to presence of differences between the effect of polishing time on the microleakage scores of materials.

  14. Analysis of select Dalbergia and trade timber using direct analysis in real time and time-of-flight mass spectrometry for CITES enforcement.

    Science.gov (United States)

    Lancaster, Cady; Espinoza, Edgard

    2012-05-15

    International trade of several Dalbergia wood species is regulated by The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). In order to supplement morphological identification of these species, a rapid chemical method of analysis was developed. Using Direct Analysis in Real Time (DART) ionization coupled with Time-of-Flight (TOF) Mass Spectrometry (MS), selected Dalbergia and common trade species were analyzed. Each of the 13 wood species was classified using principal component analysis and linear discriminant analysis (LDA). These statistical data clusters served as reliable anchors for species identification of unknowns. Analysis of 20 or more samples from the 13 species studied in this research indicates that the DART-TOFMS results are reproducible. Statistical analysis of the most abundant ions gave good classifications that were useful for identifying unknown wood samples. DART-TOFMS and LDA analysis of 13 species of selected timber samples and the statistical classification allowed for the correct assignment of unknown wood samples. This method is rapid and can be useful when anatomical identification is difficult but needed in order to support CITES enforcement. Published 2012. This article is a US Government work and is in the public domain in the USA.

  15. Working hours and all-cause mortality in relation to the EU Working Time Directive: a Danish cohort study.

    Science.gov (United States)

    Hannerz, Harald; Soll-Johanning, Helle

    2018-03-12

    In keeping with the need to protect the safety and health of workers, the EU Working Time Directive stipulates that a worker's average working time for each 7-day period, including overtime, does not exceed 48 h. It has, however, not been settled whether or not the threshold at 48 working hours a week is low enough to protect against excess mortality from long work weeks. The aim of the present study was to examine all-cause mortality in relation to weekly working hours among employees in the general population of Denmark. A special attention was given to mortality rates among employees with moderately long work weeks, 41-48 h. Interview data from cohorts of 20-64 year-old employees were drawn from the Danish Labour Force Survey. The participants (N = 159 933) were followed through national registers from the end of the calendar year of the interview (1999-2013) until the end of 2014. Rate ratios (RRs) for all-cause mortality were estimated as a function of weekly working hours while controlling for age, sex, social class, night-time work and calendar year. We found 3374 deaths during an average follow-up time of 7.7 years. With 32-40 working hours a week as reference, the RRs for all-cause mortality were 0.75 (95% CI: 0.66-0.85) for 41-48 and 0.92 (0.80-1.05) for >48 h. Mortality rates in Denmark are significantly lower among employees with moderately long work weeks than they are among full-time employees without overtime work.

  16. Incorporating fault zone head wave and direct wave secondary arrival times into seismic tomography: Application at Parkfield, California

    Science.gov (United States)

    Bennington, Ninfa L.; Thurber, Clifford; Peng, Zhigang; Zhang, Haijiang; Zhao, Peng

    2013-03-01

    We present a three-dimensional (3D) P wave velocity (Vp) model of the Parkfield region that utilizes existing P wave arrival time data, including fault zone head waves (FZHWs), and data from direct wave secondary arrivals (DWSAs). The first-arrival and DWSA travel times are obtained as the global- and local-minimum travel time paths, respectively. The inclusion of FZHWs and DWSAs results in as much as a 5% and a 10% increase in the across-fault velocity contrast, respectively, for the Vp model at Parkfield relative to that of Thurber et al. [2006]. Viewed along strike, three pronounced velocity contrast regions are observed: a pair of strong positive velocity contrasts (SW fast), one NW of the 1966 Parkfield earthquake hypocenter and the other SE of the 2004 Parkfield earthquake hypocenter, and a strong negative velocity contrast (NE fast) between the two hypocenters. The negative velocity contrast partially to entirely encompasses peak coseismic slip estimated in several slip models for the 2004 earthquake, suggesting that the negative velocity contrast played a part in defining the rupture patch of the 2004 Parkfield earthquake. Following Ampuero and Ben-Zion (2008), the pattern of velocity contrasts is consistent with the observed bilateral rupture propagation for the 2004 Parkfield earthquake. Although the velocity contrasts also suggest bilateral rupture propagation for the 1966 Parkfield earthquake, the fault is creeping to the NW here, i.e., exhibiting velocity-strengthening behavior. Thus, it is not surprising that rupture propagated only SE during this event.

  17. Dormancy release and flowering time in Ziziphus jujuba Mill., a "direct flowering" fruit tree, has a facultative requirement for chilling.

    Science.gov (United States)

    Meir, Michal; Ransbotyn, Vanessa; Raveh, Eran; Barak, Simon; Tel-Zur, Noemi; Zaccai, Michele

    2016-03-15

    In deciduous fruit trees, the effect of chilling on flowering has mostly been investigated in the "indirect flowering" group, characterized by a period of rest between flower bud formation and blooming. In the present study, we explored the effects of chilling and chilling deprivation on the flowering of Ziziphus jujuba, a temperate deciduous fruit tree belonging to the "direct flowering" group, in which flower bud differentiation, blooming and fruit development occur after dormancy release, during a single growing season. Dormancy release, vegetative growth and flowering time in Z. jujuba cv. Ben-Li were assessed following several treatments of chilling. Chilling treatments quantitatively decreased the timing of vegetative bud dormancy release, thereby accelerating flowering, but had no effect on the time from dormancy release to flowering. Trees grown at a constant temperature of 25°C, without chilling, broke dormancy and flowered, indicating the facultative character of chilling in this species. We measured the expression of Z. jujuba LFY and AP1 homologues (ZjLFY and ZjAP1). Chilling decreased ZjLFY expression in dormant vegetative buds but had no effect on ZjAP1expression, which reached peak expression before dormancy release and at anthesis. In conclusion, chilling is not obligatory for dormancy release of Z. jujuba cv. Ben-Li vegetative buds. However, the exposure to chilling during dormancy does accelerate vegetative bud dormancy release and flowering. Copyright © 2016 Elsevier GmbH. All rights reserved.

  18. Determination of Exterior Orientation Parameters Through Direct Geo-Referencing in a Real-Time Aerial Monitoring System

    Science.gov (United States)

    Kim, H.; Lee, J.; Choi, K.; Lee, I.

    2012-07-01

    Rapid responses for emergency situations such as natural disasters or accidents often require geo-spatial information describing the on-going status of the affected area. Such geo-spatial information can be promptly acquired by a manned or unmanned aerial vehicle based multi-sensor system that can monitor the emergent situations in near real-time from the air using several kinds of sensors. Thus, we are in progress of developing such a real-time aerial monitoring system (RAMS) consisting of both aerial and ground segments. The aerial segment acquires the sensory data about the target areas by a low-altitude helicopter system equipped with sensors such as a digital camera and a GPS/IMU system and transmits them to the ground segment through a RF link in real-time. The ground segment, which is a deployable ground station installed on a truck, receives the sensory data and rapidly processes them to generate ortho-images, DEMs, etc. In order to generate geo-spatial information, in this system, exterior orientation parameters (EOP) of the acquired images are obtained through direct geo-referencing because it is difficult to acquire coordinates of ground points in disaster area. The main process, since the data acquisition stage until the measurement of EOP, is discussed as follows. First, at the time of data acquisition, image acquisition time synchronized by GPS time is recorded as part of image file name. Second, the acquired data are then transmitted to the ground segment in real-time. Third, by processing software for ground segment, positions/attitudes of acquired images are calculated through a linear interpolation using the GPS time of the received position/attitude data and images. Finally, the EOPs of images are obtained from position/attitude data by deriving the relationships between a camera coordinate system and a GPS/IMU coordinate system. In this study, we evaluated the accuracy of the EOP decided by direct geo-referencing in our system. To perform this

  19. DETERMINATION OF EXTERIOR ORIENTATION PARAMETERS THROUGH DIRECT GEO-REFERENCING IN A REAL-TIME AERIAL MONITORING SYSTEM

    Directory of Open Access Journals (Sweden)

    H. Kim

    2012-07-01

    Full Text Available Rapid responses for emergency situations such as natural disasters or accidents often require geo-spatial information describing the on-going status of the affected area. Such geo-spatial information can be promptly acquired by a manned or unmanned aerial vehicle based multi-sensor system that can monitor the emergent situations in near real-time from the air using several kinds of sensors. Thus, we are in progress of developing such a real-time aerial monitoring system (RAMS consisting of both aerial and ground segments. The aerial segment acquires the sensory data about the target areas by a low-altitude helicopter system equipped with sensors such as a digital camera and a GPS/IMU system and transmits them to the ground segment through a RF link in real-time. The ground segment, which is a deployable ground station installed on a truck, receives the sensory data and rapidly processes them to generate ortho-images, DEMs, etc. In order to generate geo-spatial information, in this system, exterior orientation parameters (EOP of the acquired images are obtained through direct geo-referencing because it is difficult to acquire coordinates of ground points in disaster area. The main process, since the data acquisition stage until the measurement of EOP, is discussed as follows. First, at the time of data acquisition, image acquisition time synchronized by GPS time is recorded as part of image file name. Second, the acquired data are then transmitted to the ground segment in real-time. Third, by processing software for ground segment, positions/attitudes of acquired images are calculated through a linear interpolation using the GPS time of the received position/attitude data and images. Finally, the EOPs of images are obtained from position/attitude data by deriving the relationships between a camera coordinate system and a GPS/IMU coordinate system. In this study, we evaluated the accuracy of the EOP decided by direct geo-referencing in our system

  20. Remote Sensing Time Series to Evaluate Direct Land Use Change of Recent Expanded Sugarcane Crop in Brazil

    Directory of Open Access Journals (Sweden)

    Marcio Pupin Mello

    2012-04-01

    Full Text Available The use of biofuels to mitigate global carbon emissions is highly dependent on direct and indirect land use changes (LUC. The direct LUC (dLUC can be accurately evaluated using remote sensing images. In this work we evaluated the dLUC of about 4 million hectares of sugarcane expanded from 2005 to 2010 in the South-central region of Brazil. This region has a favorable climate for rain-fed sugarcane, a great potential for agriculture expansion without deforestation, and is currently responsible for almost 90% of Brazilian’s sugarcane production. An available thematic map of sugarcane along with MODIS and Landast images, acquired from 2000 to 2009, were used to evaluate the land use prior to the conversion to sugarcane. A systematic sampling procedure was adopted and the land use identification prior to sugarcane, for each sample, was performed using a web tool developed to visualize both the MODIS time series and the multitemporal Landsat images. Considering 2000 as reference year, it was observed that sugarcane expanded: 69.7% on pasture land; 25.0% on annual crops; 0.6% on forest; while 3.4% was sugarcane land under crop rotation. The results clearly show that the dLUC of recent sugarcane expansion has occurred on more than 99% of either pasture or agriculture land.

  1. Use of quantitative real-time PCR for direct detection of serratia marcescens in marine and other aquatic environments.

    Science.gov (United States)

    Joyner, Jessica; Wanless, David; Sinigalliano, Christopher D; Lipp, Erin K

    2014-03-01

    Serratia marcescens is the etiological agent of acroporid serratiosis, a distinct form of white pox disease in the threatened coral Acropora palmata. The pathogen is commonly found in untreated human waste in the Florida Keys, which may contaminate both nearshore and offshore waters. Currently there is no direct method for detection of this bacterium in the aquatic or reef environment, and culture-based techniques may underestimate its abundance in marine waters. A quantitative real-time PCR assay was developed to detect S. marcescens directly from environmental samples, including marine water, coral mucus, sponge tissue, and wastewater. The assay targeted the luxS gene and was able to distinguish S. marcescens from other Serratia species with a reliable quantitative limit of detection of 10 cell equivalents (CE) per reaction. The method could routinely discern the presence of S. marcescens for as few as 3 CE per reaction, but it could not be reliably quantified at this level. The assay detected environmental S. marcescens in complex sewage influent samples at up to 761 CE ml(-1) and in septic system-impacted residential canals in the Florida Keys at up to 4.1 CE ml(-1). This detection assay provided rapid quantitative abilities and good sensitivity and specificity, which should offer an important tool for monitoring this ubiquitous pathogen that can potentially impact both human health and coral health.

  2. Direct Analysis in Real-time Mass Spectrometry for Rapid Identification of Traditional Chinese Medicines with Coumarins as Primary Characteristics.

    Science.gov (United States)

    Chen, Zhiyong; Yang, Yuanyuan; Tao, Hongxun; Liao, Liping; Li, Ye; Zhang, Zijia

    2017-05-01

    The increasing popularity of traditional Chinese medicines (TCMs) necessitates rapid and reliable methods for controlling their quality. Direct analysis in real-time mass spectrometry (DART-MS) represents a novel approach to analysing TCMs. To develop a quick and reliable method of identifying TCMs with coumarins as primary characteristics. DART-MS coupled with ion trap mass spectrometry was employed to rapidly identify TCMs with coumarins as primary characteristics and to explore the ionisation mechanisms of simple coumarins, furocoumarins and pyranocoumarins in detail. With minimal sample pretreatment, mass spectra of Fraxini Cortex, Angelicae Pubescentis Radix, Peucedani Radix and Psoraleae Fructus samples were obtained within seconds. The operating parameters of the DART ion source (e.g. grid electrode voltage and ionisation gas temperature) were carefully investigated to obtain high-quality mass spectra. The mass spectra of samples and DART-MS/MS spectra of marker compounds were used to identify sample materials. Successful authentication was achieved by analysing the same materials of different origins. Some simple coumarins, furocoumarins and pyranocoumarins can be directly detected by DART-MS as marker compounds. Our results demonstrated that DART-MS can provide a rapid and reliable method for the identification of TCMs containing different configurations of coumarins; the method may also be applicable to other plants. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Real time analysis of brain tissue by direct combination of ultrasonic surgical aspiration and sonic spray mass spectrometry.

    Science.gov (United States)

    Schäfer, Karl-Christian; Balog, Júlia; Szaniszló, Tamás; Szalay, Dániel; Mezey, Géza; Dénes, Júlia; Bognár, László; Oertel, Matthias; Takáts, Zoltán

    2011-10-15

    Direct combination of cavitron ultrasonic surgical aspirator (CUSA) and sonic spray ionization mass spectrometry is presented. A commercially available ultrasonic surgical device was coupled to a Venturi easy ambient sonic-spray ionization (V-EASI) source by directly introducing liquified tissue debris into the Venturi air jet pump. The Venturi air jet pump was found to efficiently nebulize the suspended tissue material for gas phase ion production. The ionization mechanism involving solely pneumatic spraying was associated with that of sonic spray ionization. Positive and negative ionization spectra were obtained from brain and liver samples reflecting the primary application areas of the surgical device. Mass spectra were found to feature predominantly complex lipid-type constituents of tissues in both ion polarity modes. Multiply charged peptide anions were also detected. The influence of instrumental settings was characterized in detail. Venturi pump geometry and flow parameters were found to be critically important in ionization efficiency. Standard solutions of phospholipids and peptides were analyzed in order to test the dynamic range, sensitivity, and suppression effects. The spectra of the intact tissue specimens were found to be highly specific to the histological tissue type. The principal component analysis (PCA) and linear discriminant analysis (LDA) based data analysis method was developed for real-time tissue identification in a surgical environment. The method has been successfully tested on post-mortem and ex vivo human samples including astrocytomas, meningeomas, metastatic brain tumors, and healthy brain tissue. © 2011 American Chemical Society

  4. Delay-dependent exponential stability analysis of bi-directional associative memory neural networks with time delay: an LMI approach

    International Nuclear Information System (INIS)

    Li Chuandong; Liao Xiaofeng; Zhang Rong

    2005-01-01

    For bi-directional associative memory (BAM) neural networks (NNs) with different constant or time-varying delays, the problems of determining the exponential stability and estimating the exponential convergence rate are investigated in this paper. An approach combining the Lyapunov-Krasovskii functional with the linear matrix inequality (LMI) is taken to study the problems, which provide bounds on the interconnection matrix and the activation functions, so as to guarantee the system's exponential stability. Some criteria for the exponential stability, which give information on the delay-dependent property, are derived. The results obtained in this paper provide one more set of easily verified guidelines for determining the exponential stability of delayed BAM (DBAM) neural networks, which are less conservative and less restrictive than the ones reported so far in the literature. Some typical examples are presented to show the application of the criteria obtained in this paper

  5. Analysis of hairy root culture of Rauvolfia serpentina using direct analysis in real time mass spectrometric technique.

    Science.gov (United States)

    Madhusudanan, K P; Banerjee, Suchitra; Khanuja, Suman P S; Chattopadhyay, Sunil K

    2008-06-01

    The applicability of a new mass spectrometric technique, DART (direct analysis in real time) has been studied in the analysis of the hairy root culture of Rauvolfia serpentina. The intact hairy roots were analyzed by holding them in the gap between the DART source and the mass spectrometer for measurements. Two nitrogen-containing compounds, vomilenine and reserpine, were characterized from the analysis of the hairy roots almost instantaneously. The confirmation of the structures of the identified compounds was made through their accurate molecular formula determinations. This is the first report of the application of DART technique for the characterization of compounds that are expressed in the hairy root cultures of Rauvolfia serpentina. Moreover, this also constitutes the first report of expression of reserpine in the hairy root culture of Rauvolfia serpentina. Copyright (c) 2008 John Wiley & Sons, Ltd.

  6. Direct Structural and Chemical Characterization of the Photolytic Intermediates of Methylcobalamin Using Time-Resolved X-ray Absorption Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Subramanian, Ganesh; Zhang, Xiaoyi; Kodis, Gerdenis; Kong, Qingyu; Liu, Cunming; Chizmeshya, Andrew; Weierstall, Uwe; Spence, John

    2018-04-05

    Cobalt−carbon bond cleavage is crucial to most natural and synthetic applications of the cobalamin class of compounds, and here we present the first direct electronic and geometric structural characteristics of intermediates formed following photoexcitation of methylcobalamin (MeCbl) using time-resolved X-ray absorption spectroscopy (XAS). We catch transients corresponding to two intermediates, in the hundreds of picoseconds and a few microseconds. Highlights of the picosecond intermediate, which is reduced in comparison to the ground state, are elongation of the upper axial Co−C bond and relaxation of the corrin ring. This is not so with the recombining photocleaved products captured at a few microseconds, where the Co−C bond almost (yet not entirely) reverts to its ground state configuration and a substantially elongated lower axial Co−NIm bond is observed. The reduced cobalt site here confirms formation of methyl radical as the photoproduct.

  7. Implementation of the European Working Time Directive in an NHS trust: impact on patient care and junior doctor welfare.

    Science.gov (United States)

    McIntyre, Hugh F; Winfield, Sarah; Te, Hui Sen; Crook, David

    2010-04-01

    To comply with the European Working Time Directive (EWTD), from 1 August 2009, junior doctors are required to work no more than 48 hours per week. In accordance with this, East Sussex Hospitals Trust introduced changes to working practice in August 2007. To assess the impact upon patient care and junior doctor welfare a retrospective observational survey comparing data from the year prior to and the year following August 2007 was conducted. No impact on the standard of patient care, as measured by length of stay, death during admission or readmission was found. However, there was a notable increase in episodes of sick leave among junior doctors. Implementation of the EWTD may maintain standards of patient care but may be detrimental to the welfare of doctors in training.

  8. Detection of nicotine as an indicator of tobacco smoke by direct analysis in real time (DART) tandem mass spectrometry

    Science.gov (United States)

    Kuki, Ákos; Nagy, Lajos; Nagy, Tibor; Zsuga, Miklós; Kéki, Sándor

    2015-01-01

    The residual tobacco smoke contamination (thirdhand smoke, THS) on the clothes of a smoker was examined by direct analysis in real time (DART) mass spectrometry. DART-MS enabled sensitive and selective analysis of nicotine as the indicator of tobacco smoke pollution. Tandem mass spectrometric (MS/MS) experiments were also performed to confirm the identification of nicotine. Transferred thirdhand smoke originated from the fingers of a smoker onto other objects was also detected by DART mass spectrometry. DART-MS/MS was utilized for monitoring the secondhand tobacco smoke (SHS) in the air of the laboratory using nicotine as an indicator. To the best of our knowledge, this is the first report on the application of DART-MS and DART-MS/MS to the detection of thirdhand smoke and to the monitoring of secondhand smoke.

  9. Connecting speeds, directions and arrival times of 22 coronal mass ejections from the sun to 1 AU

    Energy Technology Data Exchange (ETDEWEB)

    Möstl, C.; Veronig, A. M.; Rollett, T.; Temmer, M.; Peinhart, V. [Kanzelhöhe Observatory-IGAM, Institute of Physics, University of Graz (Austria); Amla, K.; Hall, J. R.; Liewer, P. C.; De Jong, E. M. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA (United States); Colaninno, R. C. [Space Sciences Division, Naval Research Laboratory, Washington, DC (United States); Davies, J. A.; Harrison, R. A. [RAL Space, Harwell Oxford, Didcot (United Kingdom); Lugaz, N.; Farrugia, C. J.; Galvin, A. B. [Space Science Center and Department of Physics, University of New Hampshire, Durham, NH (United States); Liu, Y. D. [State Key Laboratory of Space Weather, National Space Science Center, Chinese Academy of Sciences, Beijing (China); Luhmann, J. G. [Space Science Laboratory, University of California, Berkeley, CA (United States); Vršnak, B., E-mail: christian.moestl@uni-graz.at [Hvar Observatory, Faculty of Geodesy, University of Zagreb, Kačićeva 26, HR-10000, Zagreb (Croatia)

    2014-06-01

    Forecasting the in situ properties of coronal mass ejections (CMEs) from remote images is expected to strongly enhance predictions of space weather and is of general interest for studying the interaction of CMEs with planetary environments. We study the feasibility of using a single heliospheric imager (HI) instrument, imaging the solar wind density from the Sun to 1 AU, for connecting remote images to in situ observations of CMEs. We compare the predictions of speed and arrival time for 22 CMEs (in 2008-2012) to the corresponding interplanetary coronal mass ejection (ICME) parameters at in situ observatories (STEREO PLASTIC/IMPACT, Wind SWE/MFI). The list consists of front- and backsided, slow and fast CMEs (up to 2700 km s{sup –1}). We track the CMEs to 34.9 ± 7.1 deg elongation from the Sun with J maps constructed using the SATPLOT tool, resulting in prediction lead times of –26.4 ± 15.3 hr. The geometrical models we use assume different CME front shapes (fixed-Φ, harmonic mean, self-similar expansion) and constant CME speed and direction. We find no significant superiority in the predictive capability of any of the three methods. The absolute difference between predicted and observed ICME arrival times is 8.1 ± 6.3 hr (rms value of 10.9 hr). Speeds are consistent to within 284 ± 288 km s{sup –1}. Empirical corrections to the predictions enhance their performance for the arrival times to 6.1 ± 5.0 hr (rms value of 7.9 hr), and for the speeds to 53 ± 50 km s{sup –1}. These results are important for Solar Orbiter and a space weather mission positioned away from the Sun-Earth line.

  10. Authentication of animal fats using direct analysis in real time (DART) ionization-mass spectrometry and chemometric tools.

    Science.gov (United States)

    Vaclavik, Lukas; Hrbek, Vojtech; Cajka, Tomas; Rohlik, Bo-Anne; Pipek, Petr; Hajslova, Jana

    2011-06-08

    A combination of direct analysis in real time (DART) ionization coupled to time-of-flight mass spectrometry (TOFMS) and chemometrics was used for animal fat (lard and beef tallow) authentication. This novel instrumentation was employed for rapid profiling of triacylglycerols (TAGs) and polar compounds present in fat samples and their mixtures. Additionally, fat isolated from pork, beef, and pork/beef admixtures was analyzed. Mass spectral records were processed by principal component analysis (PCA) and stepwise linear discriminant analysis (LDA). DART-TOFMS profiles of TAGs were found to be more suitable for the purpose of discrimination among the examined fat types as compared to profiles of polar compounds. The LDA model developed using TAG data enabled not only reliable classification of samples representing neat fats but also detection of admixed lard and tallow at adulteration levels of 5 and 10% (w/w), respectively. The presented approach was also successfully applied to minced meat prepared from pork and beef with comparable fat content. Using the DART-TOFMS TAG profiles of fat isolated from meat mixtures, detection of 10% pork added to beef and vice versa was possible.

  11. Direct measurements of multi-photon induced nonlinear lattice dynamics in semiconductors via time-resolved x-ray scattering.

    Science.gov (United States)

    Williams, G Jackson; Lee, Sooheyong; Walko, Donald A; Watson, Michael A; Jo, Wonhuyk; Lee, Dong Ryeol; Landahl, Eric C

    2016-12-22

    Nonlinear optical phenomena in semiconductors present several fundamental problems in modern optics that are of great importance for the development of optoelectronic devices. In particular, the details of photo-induced lattice dynamics at early time-scales prior to carrier recombination remain poorly understood. We demonstrate the first integrated measurements of both optical and structural, material-dependent quantities while also inferring the bulk impulsive strain profile by using high spatial-resolution time-resolved x-ray scattering (TRXS) on bulk crystalline gallium arsenide. Our findings reveal distinctive laser-fluence dependent crystal lattice responses, which are not described by previous TRXS experiments or models. The initial linear expansion of the crystal upon laser excitation stagnates at a laser fluence corresponding to the saturation of the free carrier density before resuming expansion in a third regime at higher fluences where two-photon absorption becomes dominant. Our interpretations of the lattice dynamics as nonlinear optical effects are confirmed by numerical simulations and by additional measurements in an n-type semiconductor that allows higher-order nonlinear optical processes to be directly observed as modulations of x-ray diffraction lineshapes.

  12. Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool.

    Science.gov (United States)

    Yan, Binjun; Chen, Teng; Xu, Zhilin; Qu, Haibin

    2014-06-01

    The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process development method, which used direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool for studying the chromatographic process of Ginkgo biloba L., as an example. The breakthrough curves were fast determined by DART-MS at-line. A high correlation coefficient of 0.9520 was found between the concentrations of ginkgolide A determined by DART-MS and HPLC. Based on the PAT tool, the impacts of process parameters on the adsorption capacity were discovered rapidly, which showed a decreased adsorption capacity with the increase of the flow rate. This work has shown the feasibility and advantages of integrating PAT into QbD implementation for rapid process development. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Ambient mass spectrometry employing direct analysis in real time (DART) ion source for olive oil quality and authenticity assessment

    International Nuclear Information System (INIS)

    Vaclavik, Lukas; Cajka, Tomas; Hrbek, Vojtech; Hajslova, Jana

    2009-01-01

    A novel approach for the authentication of olive oil samples representing different quality grades has been developed. A new type of ion source, direct analysis in real time (DART), coupled to a high-resolution time-of-flight mass spectrometer (TOFMS) was employed for the comprehensive profiling of triacylglycerols (TAGs) and/or polar compounds extracted with a methanol-water mixture. The main parameters influencing the ionization efficiency of TAGs were the type of sample solvent, degree of sample dilution, ion beam temperature, and presence of a dopant (ammonia vapors). The ionization yield of polar compounds depended mainly on a content of water in the extract and ion beam temperature. Using DART-TOFMS, not only differentiation among extra virgin olive oil (EVOO), olive pomace oil (OPO) and olive oil (OO) could be easily achieved, but also EVOO adulteration with commonly used adulterant, hazelnut oil (HO), was feasible. Based on the linear discriminant analysis (LDA), the introduced method allowed detection of HO addition of 6 and 15% (v/v) when assessing DART-TOFMS mass profiles of polar compounds and TAGs, respectively.

  14. Ambient mass spectrometry employing direct analysis in real time (DART) ion source for olive oil quality and authenticity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Vaclavik, Lukas; Cajka, Tomas; Hrbek, Vojtech [Institute of Chemical Technology Prague, Faculty of Food and Biochemical Technology, Department of Food Chemistry and Analysis, Technicka 5, 166 28 Prague 6 (Czech Republic); Hajslova, Jana, E-mail: jana.hajslova@vscht.cz [Institute of Chemical Technology Prague, Faculty of Food and Biochemical Technology, Department of Food Chemistry and Analysis, Technicka 5, 166 28 Prague 6 (Czech Republic)

    2009-07-10

    A novel approach for the authentication of olive oil samples representing different quality grades has been developed. A new type of ion source, direct analysis in real time (DART), coupled to a high-resolution time-of-flight mass spectrometer (TOFMS) was employed for the comprehensive profiling of triacylglycerols (TAGs) and/or polar compounds extracted with a methanol-water mixture. The main parameters influencing the ionization efficiency of TAGs were the type of sample solvent, degree of sample dilution, ion beam temperature, and presence of a dopant (ammonia vapors). The ionization yield of polar compounds depended mainly on a content of water in the extract and ion beam temperature. Using DART-TOFMS, not only differentiation among extra virgin olive oil (EVOO), olive pomace oil (OPO) and olive oil (OO) could be easily achieved, but also EVOO adulteration with commonly used adulterant, hazelnut oil (HO), was feasible. Based on the linear discriminant analysis (LDA), the introduced method allowed detection of HO addition of 6 and 15% (v/v) when assessing DART-TOFMS mass profiles of polar compounds and TAGs, respectively.

  15. Direct analysis in real time mass spectrometry of potential by-products from homemade nitrate ester explosive synthesis.

    Science.gov (United States)

    Sisco, Edward; Forbes, Thomas P

    2016-04-01

    This work demonstrates the coupling of direct analysis in real time (DART) ionization with time-of-flight mass spectrometry (MS) in an off-axis configuration for the trace detection and analysis of potential partially nitrated and dimerized by-products of homemade nitrate ester explosive synthesis. Five compounds relating to the synthesis of nitroglycerin (NG) and pentaerythritol tetranitrate (PETN) were examined. Deprotonated ions and adducts with molecular oxygen, nitrite, and nitrate were observed in the mass spectral responses of these compounds. A global optimum temperature of 350 °C for the by-products investigated here enabled single nanogram to sub nanogram trace detection. Matrix effects were examined through a series of mixtures containing one or more compounds (sugar alcohol precursors, by-products, and/or explosives) across a range of mass loadings. The explosives MS responses experienced competitive ionization in the presence of all by-products. The magnitude of this influence corresponded to both the degree of by-product nitration and the relative mass loading of the by-product to the explosive. This work provides a characterization of potential by-products from homemade nitrate ester synthesis, including matrix effects and potential challenges that might arise from the trace detection of homemade explosives (HMEs) containing impurities. Detection and understanding of HME impurities and complex mixtures may provide valuable information for the screening and sourcing of homemade nitrate ester explosives. Published by Elsevier B.V.

  16. Student Self-Assessment of Operative Dentistry Experiences: A Time-Dependent Exercise in Self-Directed Learning.

    Science.gov (United States)

    Metz, Michael J; Durski, Marcelo T; O'Malley DeGaris, Megan; Daugherty, Timothy C; Vaught, Randall L; Cornelius, Celine Joyce; Mayfield, Theresa G

    2017-05-01

    The aim of this study was to evaluate the process of student self-assessment on operative dentistry skills across four years at the University of Louisville School of Dentistry. First, a retrospective analysis of the Class of 2016 students' self-assessment and faculty assessment grade sheets was conducted to determine mean differences and correlations across time. Both preclinical (D2: n=120) and clinical (D3: n=120; D4: n=120) grade sheets were evaluated. Second, 25 students from each of the D1, D2, D3, and D4 classes in 2016 were asked to evaluate dentoform work, and 25 operative calibrated faculty members graded the same two dentoforms. The results of the retrospective analysis were that the D2 students' self-assessment scores were significantly higher than the faculty scores (t-test; pself-assessment scores were also significantly higher than the faculty scores (t-test; pself-assessment scores were not significantly different from the faculty scores (t-test; p>0.05), and there was a positive correlation (r=0.408). In the prospective analysis, the D1, D2, and D3 students graded the dentoforms significantly higher (ANOVA; pself-assessment is a learned process through experiential and continual encounters across time. The summative goal for all dental schools is to provide students with the skills and knowledge to critically evaluate their work for self-directed learning.

  17. Direct analysis in real time mass spectrometry, a process analytical technology tool for real-time process monitoring in botanical drug manufacturing.

    Science.gov (United States)

    Wang, Lu; Zeng, Shanshan; Chen, Teng; Qu, Haibin

    2014-03-01

    A promising process analytical technology (PAT) tool has been introduced for batch processes monitoring. Direct analysis in real time mass spectrometry (DART-MS), a means of rapid fingerprint analysis, was applied to a percolation process with multi-constituent substances for an anti-cancer botanical preparation. Fifteen batches were carried out, including ten normal operations and five abnormal batches with artificial variations. The obtained multivariate data were analyzed by a multi-way partial least squares (MPLS) model. Control trajectories were derived from eight normal batches, and the qualification was tested by R(2) and Q(2). Accuracy and diagnosis capability of the batch model were then validated by the remaining batches. Assisted with high performance liquid chromatography (HPLC) determination, process faults were explained by corresponding variable contributions. Furthermore, a batch level model was developed to compare and assess the model performance. The present study has demonstrated that DART-MS is very promising in process monitoring in botanical manufacturing. Compared with general PAT tools, DART-MS offers a particular account on effective compositions and can be potentially used to improve batch quality and process consistency of samples in complex matrices. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. 46 CFR 308.403 - Insured amounts.

    Science.gov (United States)

    2010-10-01

    ... total amount of war risk insurance obtainable from companies authorized to do an insurance business in a... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Builder's Risk Insurance § 308.403 Insured amounts. (a) Prelaunching period. The amount insured during...

  19. 13 CFR 400.202 - Loan amount.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan amount. 400.202 Section 400.202 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.202 Loan amount. (a) The aggregate amount of loan principal guaranteed...

  20. 13 CFR 500.202 - Loan amount.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan amount. 500.202 Section 500.202 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL AND GAS GUARANTEED LOAN PROGRAM Oil and Gas Guaranteed Loans § 500.202 Loan amount. The aggregate amount of loan...

  1. 45 CFR 32.8 - Amounts withheld.

    Science.gov (United States)

    2010-10-01

    ...) of this section, or (ii) An amount equal to 25% of the debtor's disposable pay less the amount(s... first pay day after the employer receives the order. However, if the first pay day is within 10 days after receipt of the order, the employer may begin deductions on the second pay day. (k) An employer may...

  2. 31 CFR 235.5 - Reclamation amounts.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Reclamation amounts. 235.5 Section 235.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... ON DESIGNATED DEPOSITARIES § 235.5 Reclamation amounts. Amounts received by way of reclamation on...

  3. In-cylinder pressure-based direct techniques and time frequency analysis for combustion diagnostics in IC engines

    International Nuclear Information System (INIS)

    D’Ambrosio, S.; Ferrari, A.; Galleani, L.

    2015-01-01

    Highlights: • Direct pressure-based techniques have been applied successfully to spark-ignition engines. • The burned mass fraction of pressure-based techniques has been compared with that of 2- and 3-zone combustion models. • The time frequency analysis has been employed to simulate complex diesel combustion events. - Abstract: In-cylinder pressure measurement and analysis has historically been a key tool for off-line combustion diagnosis in internal combustion engines, but online applications for real-time condition monitoring and combustion management have recently become popular. The present investigation presents and compares different low computing-cost in-cylinder pressure based methods for the analyses of the main features of combustion, that is, the start of combustion, the end of combustion and the crankshaft angle that responds to half of the overall burned mass. The instantaneous pressure in the combustion chamber has been used as an input datum for the described analytical procedures and it has been measured by means of a standard piezoelectric transducer. Traditional pressure-based techniques have been shown to be able to predict the burned mass fraction time history more accurately in spark ignition engines than in diesel engines. The most suitable pressure-based techniques for both spark ignition and compression ignition engines have been chosen on the basis of the available experimental data. Time–frequency analysis has also been applied to the analysis of diesel combustion, which is richer in events than spark ignited combustion. Time frequency algorithms for the calculation of the mean instantaneous frequency are computationally efficient, allow the main events of the diesel combustion to be identified and provide the greatest benefits in the presence of multiple injection events. These algorithms can be optimized and applied to onboard diagnostics tools designed for real control, but can also be used as an advanced validation tool for

  4. Temporal and bi-directional associations between sleep duration and physical activity/sedentary time in children: An international comparison.

    Science.gov (United States)

    Lin, Yingyi; Tremblay, Mark S; Katzmarzyk, Peter T; Fogelholm, Mikael; Hu, Gang; Lambert, Estelle V; Maher, Carol; Maia, Jose; Olds, Timothy; Sarmiento, Olga L; Standage, Martyn; Tudor-Locke, Catrine; Chaput, Jean-Philippe

    2018-06-01

    The purpose of this multinational and cross-sectional study was to investigate whether nighttime sleep duration was associated with physical activity (PA) and sedentary time (SED) the following day, whether daytime PA/SED were associated with sleep duration the subsequent night, and whether the associations were modified by sex and study sites. Data from 5779 children aged 9-11years were analyzed. A waist-worn Actigraph GT3X+ accelerometer was used to assess children's 24-h movement behaviours for 7days, i.e. sleep duration, total SED, light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA). Multilevel linear regression models were used to account for the repeated measures nested within participants (there were up to 7 sleep→PA/SED and PA/SED→sleep pairings per participant) and schools, and adjusted for covariates. To facilitate interpretation, all sleep and PA/SED variables were standardized. Results showed that the relationship between sleep and PA/SED is bi-directional in this international sample of children. Specifically, for each one standard deviation (SD) unit increase in sleep duration, SED the following day decreased by 0.04 SD units, while LPA and MVPA increased by 0.04 and 0.02 SD units, respectively. Sleep duration decreased by 0.02 SD units and increased by 0.04 SD units for each one SD unit increase in SED and MVPA, respectively. Sleep duration was not affected by changes in LPA. These associations differed across sex and study sites in both directions. However, since the observed effect sizes are subtle, public health initiatives should consider the clinical and practical relevance of these findings. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. A DTN-ready application for the real-time dissemination of Earth Observation data received by Direct Readout stations

    Science.gov (United States)

    Paronis, Dimitris; Daglis, Ioannis A.; Diamantopoulos, Sotirios; Tsaoussidis, Vassilis; Tsigkanos, Antonis; Ghita, Bogdan; Evans, Michael

    2014-05-01

    The majority of Earth observation satellites operate in low Earth sun-synchronous orbit and transmit data captured by a variety of sensors. The effective dissemination of satellite data in real-time is a crucial parameter for disaster monitoring in particular. Generally, a spacecraft collects data and then stores it on-board until it passes over dedicated ground stations to transmit the data. Additionally, some satellites (e.g. Terra, Aqua, Suomi-NPP, NOAA series satellites) have the so-called Direct Broadcast (DB) capability, which is based on a real-time data transmission sub-system. Compatible Direct Readout (DR) stations in direct line of sight are able to receive these transmissions. To date data exchange between DR stations have not been fully exploited for real-time data dissemination. Stations around the world store data locally, which is then disseminated on demand via Internet gateways based on the standard TCP-IP protocols. On the other hand, Delay Tolerant Networks (DTNs), which deliver data by enabling store-and-forward transmission in order to cope with link failures, service disruptions and network congestion, could prove as an alternative/complementary transmission mechanism for the efficient dissemination of data. The DTN architecture allows for efficient utilization of the network, using in-network storage and taking advantage of the network availability among the interconnected nodes. Although DTNs were originally developed for high-propagation delay, challenged connectivity environments such as deep space, the broader research community has investigated possible architectural enhancements for various emerging applications (e.g., terrestrial infrastructure, ground-to-air communications, content retrieval and dissemination). In this paper, a scheme for the effective dissemination of DB data is conceptualized, designed and implemented based on store-and-forward transmission capabilities provided by DTNs. For demonstration purposes, a set-up has

  6. A methodology for direct quantification of over-ranging length in helical computed tomography with real-time dosimetry.

    Science.gov (United States)

    Tien, Christopher J; Winslow, James F; Hintenlang, David E

    2011-01-31

    In helical computed tomography (CT), reconstruction information from volumes adjacent to the clinical volume of interest (VOI) is required for proper reconstruction. Previous studies have relied upon either operator console readings or indirect extrapolation of measurements in order to determine the over-ranging length of a scan. This paper presents a methodology for the direct quantification of over-ranging dose contributions using real-time dosimetry. A Siemens SOMATOM Sensation 16 multislice helical CT scanner is used with a novel real-time "point" fiber-optic dosimeter system with 10 ms temporal resolution to measure over-ranging length, which is also expressed in dose-length-product (DLP). Film was used to benchmark the exact length of over-ranging. Over-ranging length varied from 4.38 cm at pitch of 0.5 to 6.72 cm at a pitch of 1.5, which corresponds to DLP of 131 to 202 mGy-cm. The dose-extrapolation method of Van der Molen et al. yielded results within 3%, while the console reading method of Tzedakis et al. yielded consistently larger over-ranging lengths. From film measurements, it was determined that Tzedakis et al. overestimated over-ranging lengths by one-half of beam collimation width. Over-ranging length measured as a function of reconstruction slice thicknesses produced two linear regions similar to previous publications. Over-ranging is quantified with both absolute length and DLP, which contributes about 60 mGy-cm or about 10% of DLP for a routine abdominal scan. This paper presents a direct physical measurement of over-ranging length within 10% of previous methodologies. Current uncertainties are less than 1%, in comparison with 5% in other methodologies. Clinical implantation can be increased by using only one dosimeter if codependence with console readings is acceptable, with an uncertainty of 1.1% This methodology will be applied to different vendors, models, and postprocessing methods--which have been shown to produce over-ranging lengths

  7. Direct determination of acrylamide in food by gas chromatography-high-resolution time-of-flight mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Dunovska, Lenka [Institute of Chemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6 (Czech Republic); Cajka, Tomas [Institute of Chemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6 (Czech Republic); Hajslova, Jana [Institute of Chemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6 (Czech Republic)]. E-mail: jana.hajslova@vscht.cz; Holadova, Katerina [Institute of Chemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6 (Czech Republic)

    2006-09-25

    Simple and rapid gas chromatographic (GC) method employing a high-resolution time-of-flight mass analyzer that enables direct analysis (no derivatization) of acrylamide in various heat-processed foodstuffs has been developed and validated. Co-isolation of acrylamide precursors such as sugars and asparagine, constituting the risk of results overestimation due to additional formation of analyte in hot GC injector, is avoided by the extraction with n-propanol followed by solvent exchange to acetonitrile (MeCN). Introduction of a novel purification strategy, dispersive solid phase extraction, based on addition of primary-secondary amine (PSA) sorbent into deffated extract in MeCN, provides a significant reduction of some abundant matrix co-extracts (mainly free fatty acids). Isotope dilution technique (d{sub 3}-acrylamide as an internal standard) is employed for compensation of potential target analyte losses and/or matrix-inducted chromatographic response enhancement. Limits of quantifications (LOQs) ranged between 15 and 40 {mu}g kg{sup -1} and recoveries were between 97 and 108% depending on the examined food matrix. The repeatability of measurements (expressed as relative standard deviation, R.S.D.) was as low as 1.9% for potato crisps containing acrylamide at a level of 1 mg kg{sup -1}. Slightly higher values (R.S.D. < 4.0%) were achieved for breakfast cereals and crisp bread with approximately 10 times lower content of this processing contaminant. Trueness of results generated by this new method was demonstrated via FAPAS[reg] (Food Analysis Performance Assessment Scheme) interlaboratory proficiency tests.

  8. Argon direct analysis in real time mass spectrometry in conjunction with makeup solvents: a method for analysis of labile compounds.

    Science.gov (United States)

    Yang, Hongmei; Wan, Debin; Song, Fengrui; Liu, Zhiqiang; Liu, Shuying

    2013-02-05

    Helium direct analysis in real time (He-DART) mass spectrometry (MS) analysis of labile compounds usually tends to be challenging because of the occurrence of prominent fragmentation, which obscures the assigning of an ion to an independent species or merely a fragment in a mixture. In the present work, argon DART (Ar-DART) MS in conjunction with makeup solvents has been demonstrated to analyze a variety of labile compounds including nucleosides, alkaloids, glucose, and other small molecules. The results presented here confirm that Ar-DART can generate significantly less energetic ions than conventional He-DART and is able to produce the intact molecular ions with little or no fragmentation in both positive and negative ion modes. Adding a makeup solvent (absolute ethyl alcohol, methanol, fluorobenzene, or acetone) to the argon gas stream at the exit of the DART ion source can result in 1-2 orders of magnitude increase in detection signals. The sensitivity attainable by Ar-DART was found to be comparable to that by He-DART. The investigation of influence of solvents improves our understanding of the fundamental desorption and ionization processes in DART. The practical application of this rapid and high throughput method is demonstrated by the successful analysis of a natural product (Crude Kusnezoff Monkshood) extract, demonstrating the great potential in mixture research.

  9. Some new features of Direct Analysis in Real Time mass spectrometry utilizing the desorption at an angle option.

    Science.gov (United States)

    Chernetsova, Elena S; Revelsky, Alexander I; Morlock, Gertrud E

    2011-08-30

    The present study is a first step towards the unexplored capabilities of Direct Analysis in Real Time (DART) mass spectrometry (MS) arising from the possibility of the desorption at an angle: scanning analysis of surfaces, including the coupling of thin-layer chromatography (TLC) with DART-MS, and a more sensitive analysis due to the preliminary concentration of analytes dissolved in large volumes of liquids on glass surfaces. In order to select the most favorable conditions for DART-MS analysis, proper positioning of samples is important. Therefore, a simple and cheap technique for the visualization of the impact region of the DART gas stream onto a substrate was developed. A filter paper or TLC plate, previously loaded with the analyte, was immersed in a derivatization solution. On this substrate, owing to the impact of the hot DART gas, reaction of the analyte to a colored product occurred. An improved capability of detection of DART-MS for the analysis of liquids was demonstrated by applying large volumes of model solutions of coumaphos into small glass vessels and drying these solutions prior to DART-MS analysis under ambient conditions. This allowed the introduction of, by up to more than two orders of magnitude, increased quantities of analyte compared with the conventional DART-MS analysis of liquids. Through this improved detectability, the capabilities of DART-MS in trace analysis could be strengthened. Copyright © 2011 John Wiley & Sons, Ltd.

  10. UK doctors’ views on the implementation of the European Working Time Directive as applied to medical practice: a qualitative analysis

    Science.gov (United States)

    Clarke, Rachel T; Pitcher, Alex; Lambert, Trevor W; Goldacre, Michael J

    2014-01-01

    Objectives To report on what doctors at very different levels of seniority wrote, in their own words, about their concerns about the European Working Time Directive (EWTD) and its implementation in the National Health Service (NHS). Design All medical school graduates from 1993, 2005 and 2009 were surveyed by post and email in 2010. Setting The UK. Methods Using qualitative methods, we analysed free-text responses made in 2010, towards the end of the first year of full EWTD implementation, of three cohorts of the UK medical graduates (graduates of 1993, 2005 and 2009), surveyed as part of the UK Medical Careers Research Group's schedule of multipurpose longitudinal surveys of doctors. Results Of 2459 respondents who gave free-text comments, 279 (11%) made unprompted reference to the EWTD; 270 of the 279 comments were broadly critical. Key themes to emerge included frequent dissociation between rotas and actual hours worked, adverse effects on training opportunities and quality, concerns about patient safety, lowering of morale and job satisfaction, and attempts reportedly made in some hospitals to persuade junior doctors to collude in the inaccurate reporting of compliance. Conclusions Further work is needed to determine whether problems perceived with the EWTD, when they occur, are attributable to the EWTD itself, and shortened working hours, or to the way that it has been implemented in some hospitals. PMID:24503304

  11. UK doctors' views on the implementation of the European Working Time Directive as applied to medical practice: a qualitative analysis.

    Science.gov (United States)

    Clarke, Rachel T; Pitcher, Alex; Lambert, Trevor W; Goldacre, Michael J

    2014-02-06

    To report on what doctors at very different levels of seniority wrote, in their own words, about their concerns about the European Working Time Directive (EWTD) and its implementation in the National Health Service (NHS). All medical school graduates from 1993, 2005 and 2009 were surveyed by post and email in 2010. The UK. Using qualitative methods, we analysed free-text responses made in 2010, towards the end of the first year of full EWTD implementation, of three cohorts of the UK medical graduates (graduates of 1993, 2005 and 2009), surveyed as part of the UK Medical Careers Research Group's schedule of multipurpose longitudinal surveys of doctors. Of 2459 respondents who gave free-text comments, 279 (11%) made unprompted reference to the EWTD; 270 of the 279 comments were broadly critical. Key themes to emerge included frequent dissociation between rotas and actual hours worked, adverse effects on training opportunities and quality, concerns about patient safety, lowering of morale and job satisfaction, and attempts reportedly made in some hospitals to persuade junior doctors to collude in the inaccurate reporting of compliance. Further work is needed to determine whether problems perceived with the EWTD, when they occur, are attributable to the EWTD itself, and shortened working hours, or to the way that it has been implemented in some hospitals.

  12. Training and the European Working Time Directive: a 7 year review of paediatric anaesthetic trainee caseload data.

    Science.gov (United States)

    Fernandez, E; Williams, D G

    2009-10-01

    The implementation of the European Working Time Directive (WTD) has reduced the hours worked by trainees in the UK to a maximum of 56 h per week. With a further and final reduction to 48 h per week scheduled for August 2009, there is concern amongst doctors about the impact on training and on patient care. Paediatric anaesthesia is one of the specialist areas of anaesthesia for which the Royal College of Anaesthetists (RCoA) recommends a minimum caseload during the period of advanced training. We conducted a retrospective analysis of theatre logbook data from 62 Specialist Registrars (SpRs) who had completed a 12 month period of advanced training in paediatric anaesthesia in our institution between 2000 and 2007. After the implementation of the WTD 56 h week in 2004, the mean total number of cases performed by SpRs per year decreased from 441 to 336, a 24% reduction. We found a statistically significant reduction across all age groups with the largest reduction in the under 1 month of age group. The post-WTD group did not meet the RCoA recommended total minimum caseload or the minimum number of cases of <1 yr of age. Since the implementation of the WTD, there has been a significant reduction in the number of cases performed by SpRs in paediatric anaesthesia and they are no longer achieving the RCoA recommended minimum numbers for advanced training.

  13. Direct night-time ejection of particle-phase reduced biogenic sulfur compounds from the ocean to the atmosphere.

    Science.gov (United States)

    Gaston, Cassandra J; Furutani, Hiroshi; Guazzotti, Sergio A; Coffee, Keith R; Jung, Jinyoung; Uematsu, Mitsuo; Prather, Kimberly A

    2015-04-21

    The influence of oceanic biological activity on sea spray aerosol composition, clouds, and climate remains poorly understood. The emission of organic material and gaseous dimethyl sulfide (DMS) from the ocean represents well-documented biogenic processes that influence particle chemistry in marine environments. However, the direct emission of particle-phase biogenic sulfur from the ocean remains largely unexplored. Here we present measurements of ocean-derived particles containing reduced sulfur, detected as elemental sulfur ions (e.g., (32)S(+), (64)S2(+)), in seven different marine environments using real-time, single particle mass spectrometry; these particles have not been detected outside of the marine environment. These reduced sulfur compounds were associated with primary marine particle types and wind speeds typically between 5 and 10 m/s suggesting that these particles themselves are a primary emission. In studies with measurements of seawater properties, chlorophyll-a and atmospheric DMS concentrations were typically elevated in these same locations suggesting a biogenic source for these sulfur-containing particles. Interestingly, these sulfur-containing particles only appeared at night, likely due to rapid photochemical destruction during the daytime, and comprised up to ∼67% of the aerosol number fraction, particularly in the supermicrometer size range. These sulfur-containing particles were detected along the California coast, across the Pacific Ocean, and in the southern Indian Ocean suggesting that these particles represent a globally significant biogenic contribution to the marine aerosol burden.

  14. Rapid detection of sugar alcohol precursors and corresponding nitrate ester explosives using direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Sisco, Edward; Forbes, Thomas P

    2015-04-21

    This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstration of the effect of various parameters, such as ion polarity and in-source collision induced dissociation (CID) on the detection of these compounds is presented. Sensitivity of sugar alcohols and nitrate ester explosives was found to be greatest in negative ion mode with sensitivities ranging from hundreds of picograms to hundreds of nanograms, depending on the characteristics of the particular molecule. Altering the in-source CID potential allowed for acquisition of characteristic molecular ion spectra as well as fragmentation spectra. Additional studies were completed to identify the role of different experimental parameters on the sensitivity for these compounds. Variables that were examined included the DART gas stream temperature, the presence of a related compound (i.e., the effect of a precursor on the detection of a nitrate ester explosive), incorporation of dopant species and the role of the analysis surface. It was determined that each variable affected the response and detection of both sugar alcohols and the corresponding nitrate ester explosives. From this work, a rapid and sensitive method for the detection of individual sugar alcohols and corresponding nitrate ester explosives, or mixtures of the two, has been developed, providing a useful tool in the real-world identification of homemade explosives.

  15. Real-Time Pricing for Demand Response in Smart Grid Based on Alternating Direction Method of Multipliers

    Directory of Open Access Journals (Sweden)

    Hongbo Zhu

    2018-01-01

    Full Text Available The real-time pricing (RTP scheme is an ideal method to adjust the power balance between supply and demand in smart grid systems. This scheme has a profound impact on users’ behavior, system operation, and overall grid management in the electricity industry. In this research, we conduct an extended discussion of a RTP optimization model and give a theoretical analysis of the existence and uniqueness of the Lagrangian multiplier. A distributed optimization method based on the alternating direction method of multipliers (ADMM algorithm with Gaussian back substitution (GBS is proposed in this study. On the one hand, the proposed algorithm takes abundant advantage of the separability among variables in the model. On the other hand, the proposed algorithm can not only speed up the convergence rate to enhance the efficiency of computing, but also overcome the deficiency of the distributed dual subgradient algorithm, the possibility of nonconvergence in the iteration process. In addition, we give the theoretical proof of the convergence of the proposed algorithm. Furthermore, the interdependent relationship between variables has been discussed in depth during numerical simulations in the study. Compared with the dual subgradient method, the simulation results validate that the proposed algorithm has a higher convergence speed and better implementation effect.

  16. The impact of the European Working Time Directive 10 years on: views of the UK medical graduates of 2002 surveyed in 2013-2014.

    Science.gov (United States)

    Lambert, Trevor W; Smith, Fay; Goldacre, Michael J

    2016-03-01

    To report doctors' views about the European Working Time Directive ('the Directive'). Survey of the medical graduates of 2002 (surveyed in 2013-2014). Medical graduates. UK. Questions on views about the Directive. The response rate was 64% (2056/3196). Twelve per cent of respondents agreed that the Directive had benefited senior doctors, 39% that it benefited junior doctors, and 17% that it had benefited the NHS. More women (41%) than men (35%) agreed that the Directive had benefited junior doctors. Surgeons (6%) and adult medical specialists (8%) were least likely to agree that the Directive had benefited senior doctors. Surgeons (20%) were less likely than others to agree that the Directive had benefited junior doctors, whilst specialists in emergency medicine (57%) and psychiatry (52%) were more likely to agree. Surgeons (7%) were least likely to agree that the Directive had benefited the NHS. Most respondents (62%) reported a positive effect upon work-life balance. With regard to quality of patient care, 45% reported a neutral effect, 40% reported a negative effect, and 15% a positive effect. Most respondents (71%) reported a negative effect of the Directive on continuity of patient care, and 71% felt that the Directive had a negative effect upon junior doctors' training opportunities. Fifty-two per cent reported a negative effect on efficiency in managing patient care. Senior doctors agreed that the Directive benefited doctors' work-life balance. In other respects, they were more negative about it. Surgeons were the least positive about aspects of the Directive.

  17. Directing students to profound open-book test preparation : The relationship between deep learning and open-book test time

    NARCIS (Netherlands)

    Heijne-Penninga, M.; Kuks, J.B.; Hofman, W.H.; Cohen-Schotanus, J.

    2011-01-01

    Background: Considering the growing amount of medical knowledge and the focus of medical education on acquiring competences, using open-book tests seems inevitable. A possible disadvantage of these tests is that students underestimate test preparation. Aims: We examined whether students who used a

  18. Determination of the response time of pressure transducers using the direct method; Determinacao do tempo de resposta de transdutores de pressao utilizando o metodo de medida direta

    Energy Technology Data Exchange (ETDEWEB)

    Perillo, S R.P.

    1994-12-31

    The available methods to determine the response time of nuclear safety related pressure transducers are discussed, with emphasis to the direct method. In order to perform the experiments, a Hydraulic Ramp Generator was built. The equipment produces ramp pressure transients simultaneously to a reference transducer and to the transducer under test. The time lag between the output of the two transducers, when they reach a predetermined setpoint, is measured as the time delay of the transducer under test. Some results using the direct method to determine the time delay of pressure transducers (1 E Class Conventional) are presented. (author). 18 refs, 35 figs, 12 tabs.

  19. Direct Detection and Differentiation of Pathogenic Leptospira Species Using a Multi-Gene Targeted Real Time PCR Approach

    Science.gov (United States)

    Ferreira, Ana Sofia; Costa, Pedro; Rocha, Teresa; Amaro, Ana; Vieira, Maria Luísa; Ahmed, Ahmed; Thompson, Gertrude; Hartskeerl, Rudy A.; Inácio, João

    2014-01-01

    Leptospirosis is a growing public and veterinary health concern caused by pathogenic species of Leptospira. Rapid and reliable laboratory tests for the direct detection of leptospiral infections in animals are in high demand not only to improve diagnosis but also for understanding the epidemiology of the disease. In this work we describe a novel and simple TaqMan-based multi-gene targeted real-time PCR approach able to detect and differentiate Leptospira interrogans, L. kirschneri, L. borgpeteresenii and L. noguchii, which constitute the veterinary most relevant pathogenic species of Leptospira. The method uses sets of species-specific probes, and respective flanking primers, designed from ompL1 and secY gene sequences. To monitor the presence of inhibitors, a duplex amplification assay targeting both the mammal β-actin and the leptospiral lipL32 genes was implemented. The analytical sensitivity of all primer and probe sets was estimated to be <10 genome equivalents (GE) in the reaction mixture. Application of the amplification reactions on genomic DNA from a variety of pathogenic and non-pathogenic Leptospira strains and other non-related bacteria revealed a 100% analytical specificity. Additionally, pathogenic leptospires were successfully detected in five out of 29 tissue samples from animals (Mus spp., Rattus spp., Dolichotis patagonum and Sus domesticus). Two samples were infected with L. borgpetersenii, two with L. interrogans and one with L. kirschneri. The possibility to detect and identify these pathogenic agents to the species level in domestic and wildlife animals reinforces the diagnostic information and will enhance our understanding of the epidemiology of leptopirosis. PMID:25398140

  20. UK doctors' views on the implementation of the European Working Time Directive as applied to medical practice: a quantitative analysis.

    Science.gov (United States)

    Maisonneuve, Jenny J; Lambert, Trevor W; Goldacre, Michael J

    2014-02-06

    To report on doctors' views, from all specialty backgrounds, about the European Working Time Directive (EWTD) and its impact on the National Health Service (NHS), senior doctors and junior doctors. All medical school graduates from 1999 to 2000 were surveyed by post and email in 2012. The UK. Among other questions, in a multipurpose survey on medical careers and career intentions, doctors were asked to respond to three statements about the EWTD on a five-point scale (from strongly agree to strongly disagree): 'The implementation of the EWTD has benefited the NHS', 'The implementation of the EWTD has benefited senior doctors' and 'The implementation of the EWTD has benefited junior doctors'. The response rate was 54.4% overall (4486/8252), 55.8% (2256/4042) of the 1999 cohort and 53% (2230/4210) of the 2000 cohort. 54.1% (2427) of all respondents were women. Only 12% (498/4136 doctors) agreed that the EWTD has benefited the NHS, 9% (377) that it has benefited senior doctors and 31% (1289) that it has benefited junior doctors. Doctors' views on EWTD differed significantly by specialty groups: 'craft' specialties such as surgery, requiring extensive experience in performing operations, were particularly critical. These cohorts have experience of working in the NHS before and after the implementation of EWTD. Their lack of support for the EWTD 4 years after its implementation should be a concern. However, it is unclear whether problems rest with the current ceiling on hours worked or with the ways in which EWTD has been implemented.

  1. Characterisation of dispersion mechanisms in an urban catchment using a deterministic spatially distributed direct hydrograph travel time model

    Science.gov (United States)

    Rossel, F.; Gironas, J. A.

    2012-12-01

    The link between stream network structure and hydrologic response for natural basins has been extensively studied. It is well known that stream network organization and flow dynamics in the reaches combine to shape the hydrologic response of natural basins. Geomorphologic dispersion and hydrodynamic dispersion along with hillslope processes control to a large extent the overall variance of the hydrograph, particularly under the assumption of constant celerity throughout the basin. In addition, a third mechanism referred as to kinematic dispersion becomes relevant when considering spatial variations of celerity. On contrary, the link between the drainage network structure and overall urban terrain, and the hydrologic response in urban catchments has been much less studied. In particular, the characterization of the different dispersion mechanisms within urban areas remains to be better understood. In such areas artificial elements are expected to contribute to the total dispersion due to the variety of geometries and the spatial distribution of imperviousness. This work quantifies the different dispersion mechanisms in an urban catchment, focusing on their relevance and the spatial scales involved. For this purpose we use the Urban Morpho-climatic Instantaneous Unit Hydrograph model, a deterministic spatially distributed direct hydrograph travel time model, which computes travel times in hillslope, pipe, street and channel cells using formulations derived from kinematic wave theory. The model was applied to the Aubeniere catchment, located in Nantes, France. Unlike stochastic models, this deterministic model allows the quantification of dispersion mechanism at the local scale (i.e. the grid-cell). We found that kinematic dispersion is more relevant for small storm events, whereas geomorphologic dispersion becomes more significant for larger storms, as the mean celerity within the catchment increases. In addition, the total dispersion relates to the drainage area in

  2. Effect of the full implementation of the European Working Time Directive on operative training in adult cardiac surgery.

    Science.gov (United States)

    Mahesh, Balakrishnan; Sharples, Linda; Codispoti, Massimiliano

    2014-01-01

    Surgical specialties rely on practice and apprenticeship to acquire technical skills. In 2009, the final reduction in working hours to 48 per week, in accordance with the European Working Time Directive (EWTD), has also led to an expansion in the number of trainees. We examined the effect of these changes on operative training in a single high-volume [>1500 procedures/year] adult cardiac surgical center. Setting: A single high-volume [>1500 procedures/year] adult cardiac surgical center. Design: Consecutive data were prospectively collected into a database and retrospectively analyzed. Procedures and Main Outcome Measures: Between January 2006 and August 2010, 6688 consecutive adult cardiac surgical procedures were analyzed. The proportion of cases offered for surgical training were compared for 2 non-overlapping consecutive time periods: 4504 procedures were performed before the final implementation of the EWTD (Phase 1: January 2006-December 2008) and 2184 procedures after the final implementation of the EWTD (Phase 2: January 2009-August 2010). Other predictors of training considered in the analysis were grade of trainee, logistic European system for cardiac operative risk evaluation (EuroSCORE), type of surgical procedure, weekend or late procedure, and consultant. Logistic regression analysis was used to determine the predictors of training cases (procedure performed by trainee) and to evaluate the effect of the EWTD on operative surgical training after correcting for confounding factors. Proportion of training cases rose from 34.6% (1558/4504) during Phase 1 to 43.6% (953/2184) in Phase 2 (p hours [153 (3.4) during Phase 1 vs 116 (5.3) during Phase 2, p hours' procedures, and surgery other than coronary artery bypass grafts. Implementation of the final phase of EWTD has not decreased training in a high-volume center. The positive adjustment of trainers' attitudes and efforts to match trainees' needs allow maintenance of adequate training, despite reduction in

  3. Long hours and stress in the UK's IT profession: has the European Union's Working Time Directive offered relief?

    OpenAIRE

    Martin, I

    2005-01-01

    Only a small amount of research thus far has investigated the relationship between the working conditions of those employed in technical professions, such as Information Technology (IT), and the implications for their well being (Sonnetag et al., 1994). In particular the IT profession in the UK appears to be at risk from a culture characterised by long working hours (Kodz, 2003). In addition to the established links between long-term computer use and upper extremity musculoskeletal disorders ...

  4. 24 CFR 201.10 - Loan amounts.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Loan amounts. 201.10 Section 201.10... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES TITLE I PROPERTY IMPROVEMENT AND MANUFACTURED HOME LOANS Loan and Note Provisions § 201.10 Loan amounts. (a) Property...

  5. Charge-Domain Signal Processing of Direct RF Sampling Mixer with Discrete-Time Filters in Bluetooth and GSM Receivers

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available RF circuits for multi-GHz frequencies have recently migrated to low-cost digital deep-submicron CMOS processes. Unfortunately, this process environment, which is optimized only for digital logic and SRAM memory, is extremely unfriendly for conventional analog and RF designs. We present fundamental techniques recently developed that transform the RF and analog circuit design complexity to digitally intensive domain for a wireless RF transceiver, so that it enjoys benefits of digital and switched-capacitor approaches. Direct RF sampling techniques allow great flexibility in reconfigurable radio design. Digital signal processing concepts are used to help relieve analog design complexity, allowing one to reduce cost and power consumption in a reconfigurable design environment. The ideas presented have been used in Texas Instruments to develop two generations of commercial digital RF processors: a single-chip Bluetooth radio and a single-chip GSM radio. We further present details of the RF receiver front end for a GSM radio realized in a 90-nm digital CMOS technology. The circuit consisting of low-noise amplifier, transconductance amplifier, and switching mixer offers 32.5 dB dynamic range with digitally configurable voltage gain of 40 dB down to 7.5 dB. A series of decimation and discrete-time filtering follows the mixer and performs a highly linear second-order lowpass filtering to reject close-in interferers. The front-end gains can be configured with an automatic gain control to select an optimal setting to form a trade-off between noise figure and linearity and to compensate the process and temperature variations. Even under the digital switching activity, noise figure at the 40 dB maximum gain is 1.8 dB and +50 dBm IIP2 at the 34 dB gain. The variation of the input matching versus multiple gains is less than 1 dB. The circuit in total occupies 3.1 mm 2 . The LNA, TA, and mixer consume less than 15.3 mA at a supply voltage of 1.4 V.

  6. Charge-Domain Signal Processing of Direct RF Sampling Mixer with Discrete-Time Filters in Bluetooth and GSM Receivers

    Directory of Open Access Journals (Sweden)

    Ho Yo-Chuol

    2006-01-01

    Full Text Available RF circuits for multi-GHz frequencies have recently migrated to low-cost digital deep-submicron CMOS processes. Unfortunately, this process environment, which is optimized only for digital logic and SRAM memory, is extremely unfriendly for conventional analog and RF designs. We present fundamental techniques recently developed that transform the RF and analog circuit design complexity to digitally intensive domain for a wireless RF transceiver, so that it enjoys benefits of digital and switched-capacitor approaches. Direct RF sampling techniques allow great flexibility in reconfigurable radio design. Digital signal processing concepts are used to help relieve analog design complexity, allowing one to reduce cost and power consumption in a reconfigurable design environment. The ideas presented have been used in Texas Instruments to develop two generations of commercial digital RF processors: a single-chip Bluetooth radio and a single-chip GSM radio. We further present details of the RF receiver front end for a GSM radio realized in a 90-nm digital CMOS technology. The circuit consisting of low-noise amplifier, transconductance amplifier, and switching mixer offers dB dynamic range with digitally configurable voltage gain of 40 dB down to dB. A series of decimation and discrete-time filtering follows the mixer and performs a highly linear second-order lowpass filtering to reject close-in interferers. The front-end gains can be configured with an automatic gain control to select an optimal setting to form a trade-off between noise figure and linearity and to compensate the process and temperature variations. Even under the digital switching activity, noise figure at the 40 dB maximum gain is 1.8 dB and dBm IIP2 at the 34 dB gain. The variation of the input matching versus multiple gains is less than 1 dB. The circuit in total occupies 3.1 . The LNA, TA, and mixer consume less than mA at a supply voltage of 1.4 V.

  7. The impact of a Critical Care Information System (CCIS) on time spent charting and in direct patient care by staff in the ICU: a review of the literature.

    Science.gov (United States)

    Mador, Rebecca L; Shaw, Nicola T

    2009-07-01

    The introduction of a Critical Care Information System (CCIS) into an intensive care unit (ICU) is purported to reduce the time health care providers (HCP) spend on documentation and increase the time available for direct patient care. However, there is a paucity of rigorous empirical research that has investigated these assertions. Moreover, those studies that have sought to elucidate the relationship between the introduction of a CCIS and the time spent by staff on in/direct patient care activities have published contradictory findings. The objective of this literature review is to establish the impact of a CCIS on time spent documenting and in direct patient care by staff in the ICU. Five electronic databases were searched including PubMed Central, EMBASE, CINAHL, IEEE Xplore, and the Cochrane Database of Systematic Reviews. Reference lists of all published papers were hand searched, and citations reviewed to identify extra papers. We included studies that were empirical articles, published in English, and provided original data on the impact of a CCIS on time spent documenting and in direct patient care by staff in the ICU. In total, 12 articles met the inclusion criteria. Workflow analysis (66%) and time-and-motion analysis (25%) were the most common forms of data collection. Three (25%) studies found an increase in time spent charting, five (42%) found no difference, and four (33%) studies reported a decrease. Results on the impact of a CCIS on direct patient care were similarly inconclusive. Due to the discrepant findings and several key methodological issues, the impact of a CCIS on time spent charting and in direct patient care remains unclear. This review highlights the need for an increase in rigorous empirical research in this area and provides recommendations for the design and implementation of future studies.

  8. Leisure-time physical activity and direct cost of short-term sickness absence among Finnish municipal employees.

    Science.gov (United States)

    Tolonen, Anu; Rahkonen, Ossi; Lahti, Jouni

    2017-03-04

    We aimed to examine the direct costs of short-term (1-14 days) sickness absence and the effect of employees' physical activity on the costs. The Finnish Helsinki Health Study survey (2007) was used in the analysis (n = 3,935). Physical activity was classified into inactive, moderately active, and vigorously active. Sickness absence (3 years follow-up) and salary data were derived from the employer's registers. On average, an employee was absent 6 days a year due to short-term sickness absence, with a production loss of 2,350 EUR during the 3 years. The vigorously active had less sickness absence than those less active. The direct cost of sickness absence of a vigorously active employee was 404 EUR less than that of an inactive employee. Promoting physical activity among employees may decrease direct cost of short-term sickness absence.

  9. Sensitivity of the activated partial thromboplastin time, the dilute Russell's viper venom time, and the kaolin clotting time for the detection of the lupus anticoagulant: a direct comparison using plasma dilutions.

    Science.gov (United States)

    Martin, B A; Branch, D W; Rodgers, G M

    1996-01-01

    Increasing dilutions of lupus anticoagulant (LA) plasmas from twelve patients were used to directly compare the sensitivity of four tests for LA. The tests evaluated were the modified Bell and Alton activated partial thromboplastin time (APTT), an APTT using a commercially prepared partial thromboplastin (Platelin LS APTT), a modified dilute Russell's viper venom time (DRVVT), and a modified kaolin clotting time (KCT). LAs were detected in all twelve plasmas by each of three tests and eleven of twelve plasmas in a fourth test when undiluted patient plasma was used. Repeating the tests after diluting the LA plasmas with normal platelet-free plasma (PFP) showed that the KCT was the most sensitive test for LA, detecting eleven of twelve LAs at a dilution of 10% patient plasma and ten of twelve LAs at a dilution of 5% patient plasma. The modified Bell and Alton APTT and the modified DRVVT had similar sensitivities at a patient plasma concentration of 10%, detecting seven of twelve and eight of twelve LAs, respectively. The Platelin LS APTT detected only four of twelve LAs at a patient plasma concentration of 10%. Our results indicate that the modified KCT is a sensitive method for the detection of LAs. The modified Bell and Alton APTT and the DRVVT were less sensitive.

  10. Trace amount analysis using spark mass spectrometry

    International Nuclear Information System (INIS)

    Stefani, Rene

    1975-01-01

    Characteristics of spark mass spectrometers (ion source, properties of the ion beam, ion optics, and performance) and their use in qualitative and quantitative analysis are described. This technique is very interesting for the semi-quantitative analysis of trace amounts, down to 10 -8 atoms. Examples of applications such as the analysis of high purity materials and non-conducting mineral samples, and determination of carbon and gas trace amounts are presented. (50 references) [fr

  11. Extended Fitts' model of pointing time in eye-gaze input system - Incorporating effects of target shape and movement direction into modeling.

    Science.gov (United States)

    Murata, Atsuo; Fukunaga, Daichi

    2018-04-01

    This study attempted to investigate the effects of the target shape and the movement direction on the pointing time using an eye-gaze input system and extend Fitts' model so that these factors are incorporated into the model and the predictive power of Fitts' model is enhanced. The target shape, the target size, the movement distance, and the direction of target presentation were set as within-subject experimental variables. The target shape included: a circle, and rectangles with an aspect ratio of 1:1, 1:2, 1:3, and 1:4. The movement direction included eight directions: upper, lower, left, right, upper left, upper right, lower left, and lower right. On the basis of the data for identifying the effects of the target shape and the movement direction on the pointing time, an attempt was made to develop a generalized and extended Fitts' model that took into account the movement direction and the target shape. As a result, the generalized and extended model was found to fit better to the experimental data, and be more effective for predicting the pointing time for a variety of human-computer interaction (HCI) task using an eye-gaze input system. Copyright © 2017. Published by Elsevier Ltd.

  12. Analysis of carbohydrates in Fusarium verticillioides using size-exclusion HPLC – DRI and direct analysis in real time ionization – time-of-flight – mass spectrometry (DART-MS)

    Science.gov (United States)

    Direct analysis in real time ionization – time-of-flight – mass spectrometry (DART-MS) and size-exclusion HPLC – DRI are used, respectively, to qualitatively and quantitatively determine the carbohydrates extracted from the corn rot fungus Fusarium verticillioides. In situ permethylation in the DART...

  13. Comments on a direct approach to finding exact invariants for one-dimensional time-dependent classical hamiltonian

    International Nuclear Information System (INIS)

    Castro Moreira, I. de.

    1983-01-01

    A method introduced by Lewis and Leach for the obtention of exact invariants of the form I = Σ p sup(n) F sub(n) (q,t) for hamiltonian systems, is generalized and applied directly on the equations of motion. It gives us a general procedure to generates exact invariants also for non hamiltonian systems. (Author) [pt

  14. Soft ionization of saturated hydrocarbons, alcohols and nonpolar compounds by negative-ion direct analysis in real-time mass spectrometry.

    Science.gov (United States)

    Cody, Robert B; Dane, A John

    2013-03-01

    Large polarizable n-alkanes (approximately C18 and larger), alcohols, and other nonpolar compounds can be detected as negative ions when sample solutions are injected directly into the sampling orifice of the atmospheric pressure interface of the time-of-flight mass spectrometer with the direct analysis in real time (DART) ion source operating in negative-ion mode. The mass spectra are dominated by peaks corresponding to [M + O2]‾(•). No fragmentation is observed, making this a very soft ionization technique for samples that are otherwise difficult to analyze by DART. Detection limits for cholesterol were determined to be in the low nanogram range.

  15. Analysis and Design of Bi-Directional DC-DC Converter in the Extended Run Time DC UPS System Based on Fuel Cell and Supercapacitor

    DEFF Research Database (Denmark)

    Zhang, Zhe; Thomsen, Ole Cornelius; Andersen, Michael A. E.

    2009-01-01

    Abstract-In this paper, an extended run time DC UPS system structure with fuel cell and supercapacitor is investigated. A wide input range bi-directional dc-dc converter is described along with the phase-shift modulation scheme and phase-shift with duty cycle control, in different modes. The deli......Abstract-In this paper, an extended run time DC UPS system structure with fuel cell and supercapacitor is investigated. A wide input range bi-directional dc-dc converter is described along with the phase-shift modulation scheme and phase-shift with duty cycle control, in different modes...

  16. Effects over time of self-reported direct and vicarious racial discrimination on depressive symptoms and loneliness among Australian school students.

    Science.gov (United States)

    Priest, Naomi; Perry, Ryan; Ferdinand, Angeline; Kelaher, Margaret; Paradies, Yin

    2017-02-03

    Racism and racial discrimination are increasingly acknowledged as a critical determinant of health and health inequalities. However, patterns and impacts of racial discrimination among children and adolescents remain under-investigated, including how different experiences of racial discrimination co-occur and influence health and development over time. This study examines associations between self-reported direct and vicarious racial discrimination experiences and loneliness and depressive symptoms over time among Australian school students. Across seven schools, 142 students (54.2% female), age at T1 from 8 to 15 years old (M = 11.14, SD = 2.2), and from diverse racial/ethnic and migration backgrounds (37.3% born in English-speaking countries as were one or both parents) self-reported racial discrimination experiences (direct and vicarious) and mental health (depressive symptoms and loneliness) at baseline and 9 months later at follow up. A full cross-lagged panel design was modelled using MPLUS v.7 with all variables included at both time points. A cross-lagged effect of perceived direct racial discrimination on later depressive symptoms and on later loneliness was found. As expected, the effect of direct discrimination on both health outcomes was unidirectional as mental health did not reciprocally influence reported racism. There was no evidence that vicarious racial discrimination influenced either depressive symptoms or loneliness beyond the effect of direct racial discrimination. Findings suggest direct racial discrimination has a persistent effect on depressive symptoms and loneliness among school students over time. Future work to explore associations between direct and vicarious discrimination is required.

  17. Direct measurement of strontium-90 and uranium-238 in soils on a real-time basis: 1994 summary report

    International Nuclear Information System (INIS)

    Schilk, A.J.; Hubbard, C.W.; Knopf, M.A.; Thompson, R.C.

    1995-04-01

    Traditional methodologies for quantitative characterization of radionuclide-contaminated soils over extended areas are often tedious, costly, and non-representative. A rapid characterization methodology was designed that provides reliable output with spatial resolution on the order of a few meters or less. It incorporates an innovative sensor of square plastic scintillating fibers that has been designed to be placed directly on or above a contaminated soil to detect and quantify high-energy beta particles associated with the decay chains of uranium and/or strontium. Under the direction and auspices of the DOE's Characterization, Monitoring, and Sensor Technology Integrated Program, Pacific Northwest Laboratory (PNL) constructed a high-energy beta scintillation sensor that was optimized for the detection and quantification of uranium and strontium contamination in surface soils (in the presence of potentially interfering natural and anthropogenic radionuclides), demonstrated and evaluated this detector in various field and laboratory scenarios, and provides this document in completion of the aforementioned requirements

  18. 29 CFR 4219.14 - Amount of liability for 20-year-limitation amounts.

    Science.gov (United States)

    2010-07-01

    ... amount equal to the present value of all initial withdrawal liability payments for which the employer was not liable pursuant to section 4219(c)(1)(B) of ERISA. The present value of such payments shall be... 29 Labor 9 2010-07-01 2010-07-01 false Amount of liability for 20-year-limitation amounts. 4219.14...

  19. A Study of Nuclear Recoils in Liquid Argon Time Projection Chamber for the Direct Detection of WIMP Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Huajie [Princeton Univ., NJ (United States)

    2014-11-01

    Robust results of WIMP direct detection experiments depend on rm understandings of nuclear recoils in the detector media. This thesis documents the most comprehensive study to date on nuclear recoils in liquid argon - a strong candidate for the next generation multi-ton scale WIMP detectors. This study investigates both the energy partition from nuclear recoil energy to secondary modes (scintillation and ionization) and the pulse shape characteristics of scintillation from nuclear recoils.

  20. How restrained eaters perceive the amount they eat.

    Science.gov (United States)

    Jansen, A

    1996-09-01

    The cognitive model of binge eating states that it is the awareness of a broken diet that disinhibits the restrained eater. It is, according to that model, the perception of having overeaten that triggers disinhibited eating. However, although the perception of the amount eaten plays a central role in cognitive restraint theory, it has never directly been tested how restrained subjects perceive the amount of food they eat. In the present studies, participants were given ad libitum access to large amounts of palatable food and both their perception of the amount eaten and their estimated caloric intake were compared with the amount they actually ate. The restrained participants in these studies ate more than the unrestrained participants. In the first and second studies, the restrained participants consumed 571 and 372 'forbidden' calories respectively, without having the feeling that they had eaten very much, let alone too much. Moreover in both studies, the restrained eaters underestimated their caloric intake, whereas unrestrained eaters estimated their caloric intake quite well. The potential implications of the present findings for the cognitive restraint model are discussed.

  1. Effect of injection timing on combustion and performance of a direct injection diesel engine running on Jatropha methyl ester

    Energy Technology Data Exchange (ETDEWEB)

    Jindal, S. [Mechanical Engineering Department, College of Technology & Engineering, Maharana Pratap University of Agriculture and Technology, Udaipur 313001 (India)

    2011-07-01

    The present study aims at evaluation of effect of injection timing on the combustion, performance and emissions of a small power diesel engine, commonly used for agriculture purpose, running on pure biodiesel, prepared from Jatropha (Jatropha curcas) vegetable oil. The effect of varying injection timing was evaluated in terms of thermal efficiency, specific fuel consumption, power and mean effective pressure, exhaust temperature, cylinder pressure, rate of pressure rise and the heat release rate. It was found that retarding the injection timing by 3 degrees enhances the thermal efficiency by about 8 percent.

  2. Applications of alternating direction methods to the solution of the time-dependent heat conduction equation with source and in transients stage

    International Nuclear Information System (INIS)

    Gebrin, A.N.

    1981-10-01

    Various types and also some variants of alternating direction methods, (A.D.M.), were applied to the solution of the time-dependent heat conduction equation, with source, in region with axial symetry. The results shown that some of the variants perform consistently better than the Classical Cranck-Nicolson method. Having in mind a combination of accuracy, ability to support larg time steps and computational efficiency, the 'alternating direction explicit', (A.D.E.) method appears as the best choice, being the 'alternating direction checkerboard', (A.D.C), method the second best. Additional operations like the exponential transformation or the truncation pos-correction don't seem to be worth, excect for some special cases. (Author) [pt

  3. Characterization of olive oil volatiles by multi-step direct thermal desorption-comprehensive gas chromatography-time-of-flight mass spectrometry using a programmed temperature vaporizing injector

    NARCIS (Netherlands)

    de Koning, S.; Kaal, E.; Janssen, H.-G.; van Platerink, C.; Brinkman, U.A.Th.

    2008-01-01

    The feasibility of a versatile system for multi-step direct thermal desorption (DTD) coupled to comprehensive gas chromatography (GC × GC) with time-of-flight mass spectrometric (TOF-MS) detection is studied. As an application the system is used for the characterization of fresh versus aged olive

  4. Prediction of acrylamide formation in biscuits based on fingerprint data generated by ambient ionization mass spectrometry employing direct analysis in real time (DART) ion source

    NARCIS (Netherlands)

    Vaclavik, Lukas; Capuano, Edoardo; Gökmen, Vural; Hajslova, Jana

    2015-01-01

    The objective of this study is the evaluation of the potential of high-throughput direct analysis in real time-high resolution mass spectrometry (DART-HRMS) fingerprinting and multivariate regression analysis in prediction of the extent of acrylamide formation in biscuit samples prepared by

  5. Directionality of auditory nerve fiber responses to pure tone stimuli in the grassfrog, Rana temporaria. II. Spike timing

    DEFF Research Database (Denmark)

    Jørgensen, M B; Christensen-Dalsgaard, J

    1997-01-01

    We studied the directionality of spike timing in the responses of single auditory nerve fibers of the grass frog, Rana temporaria, to tone burst stimulation. Both the latency of the first spike after stimulus onset and the preferred firing phase during the stimulus were studied. In addition, the ...

  6. Influencing Work-Related Learning: The Role of Job Characteristics and Self-Directed Learning Orientation in Part-Time Vocational Education

    Science.gov (United States)

    Gijbels, David; Raemdonck, Isabel; Vervecken, Dries

    2010-01-01

    Based on the Demand-Control-Support (DCS) model, the present paper aims to investigate the influence of job characteristics such as job demands, job control, social support at work and self-directed learning orientation on the work-related learning behaviour of workers. The present study was conducted in a centre for part-time vocational education…

  7. Determination of trace amount of formaldehyde base on a bromate-Malachite Green system.

    Science.gov (United States)

    Tang, Yufang; Chen, Hao; Weng, Chao; Tang, Xiaohui; Zhang, Miaoling; Hu, Tao

    2015-01-25

    A novel catalytic kinetic spectrophotometric method for determination of trace amount of formaldehyde (FA) has been established, based on catalytic effect of trace amount of FA on the oxidation of Malachite Green (MG) by potassium bromate in presence of sulfuric acid medium, and was reported for the first time. The method was monitored by measuring the decrease in absorbance of MG at 617 nm and allowed a precise determination of FA in the range of 0.003-0.08 μg mL(-1), with a limit of detection down to 1 ng mL(-1). The relative standard deviation of 10 replicate measurements was 1.63%. The method developed was approved to be sensitive, selective and accurate, and adopted to determinate free FA in samples directly with good accuracy and reproducibility. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Exploring the Amount and Type of Writing Instruction during Language Arts Instruction in Kindergarten Classrooms.

    Science.gov (United States)

    Puranik, Cynthia S; Al Otaiba, Stephanie; Sidler, Jessica Folsom; Greulich, Luana

    2014-02-01

    The objective of this exploratory investigation was to examine the nature of writing instruction in kindergarten classrooms and to describe student writing outcomes at the end of the school year. Participants for this study included 21 teachers and 238 kindergarten children from nine schools. Classroom teachers were videotaped once each in the fall and winter during the 90 minute instructional block for reading and language arts to examine time allocation and the types of writing instructional practices taking place in the kindergarten classrooms. Classroom observation of writing was divided into student-practice variables (activities in which students were observed practicing writing or writing independently) and teacher-instruction variables (activities in which the teacher was observed providing direct writing instruction). In addition, participants completed handwriting fluency, spelling, and writing tasks. Large variability was observed in the amount of writing instruction occurring in the classroom, the amount of time kindergarten teachers spent on writing and in the amount of time students spent writing. Marked variability was also observed in classroom practices both within and across schools and this fact was reflected in the large variability noted in kindergartners' writing performance.

  9. Exploring the Amount and Type of Writing Instruction during Language Arts Instruction in Kindergarten Classrooms

    Science.gov (United States)

    Puranik, Cynthia S.; Al Otaiba, Stephanie; Sidler, Jessica Folsom; Greulich, Luana

    2014-01-01

    The objective of this exploratory investigation was to examine the nature of writing instruction in kindergarten classrooms and to describe student writing outcomes at the end of the school year. Participants for this study included 21 teachers and 238 kindergarten children from nine schools. Classroom teachers were videotaped once each in the fall and winter during the 90 minute instructional block for reading and language arts to examine time allocation and the types of writing instructional practices taking place in the kindergarten classrooms. Classroom observation of writing was divided into student-practice variables (activities in which students were observed practicing writing or writing independently) and teacher-instruction variables (activities in which the teacher was observed providing direct writing instruction). In addition, participants completed handwriting fluency, spelling, and writing tasks. Large variability was observed in the amount of writing instruction occurring in the classroom, the amount of time kindergarten teachers spent on writing and in the amount of time students spent writing. Marked variability was also observed in classroom practices both within and across schools and this fact was reflected in the large variability noted in kindergartners’ writing performance. PMID:24578591

  10. The times they are a-changing: Self-directed long-term services and supports and gerontological social work.

    Science.gov (United States)

    Sciegaj, Mark; Hooyman, Nancy R; Mahoney, Kevin J; DeLuca, Casey

    2018-03-05

    The Partnerships for Person-Centered (PC) and Participant-Directed (PD) Long-Term Services and Supports (LTSS) Project (Partnerships Project) was a three-year effort funded by the New York Community Trust to develop and implement social work curriculum that would better prepare students for the changing practice demands of the aging and disability services network for self-directed LTSS (SD-LTSS). This article first describes the growth of SD-LTSS and the need for trained social workers on this service delivery model. The paper then describes the Partnerships Project that involved schools of social work along and aging and disability network organization partners in nine states. This description includes the major activities of the project including the creation of SD-LTSS competencies for social work education, the infusion of these competencies in beginning and advanced social work classes, and student assessment of their attainment of these competencies. This article then discusses the challenges to institutionalizing such curricular changes within social work programs and the need for a national strategy to train social workers for the demands of SD-LTSS.

  11. Direct determination of recoil ion detection efficiency for coincidence time-of-flight studies of molecular fragmentation

    International Nuclear Information System (INIS)

    Ben-Itzhak, I.; Carnes, K.D.; Ginther, S.G.; Johnson, D.T.; Norris, P.J.; Weaver, O.L.

    1993-01-01

    Molecular fragmentation of diatomic and small polyatomic molecules caused by fast ion impact has been studied. The evaluation of the cross sections of the different fragmentation channels depends strongly on the recoil ion detection efficiency, ε r (single ions proportional to ε r , and ion pairs to ε 2 r , etc.). A method is suggested for the direct determination of this detection efficiency. This method is based on the fact that fast H + + CH 4 collisions produce C 2+ fragments only in coincidence with H + and H + 2 fragments, that is, there is a negligible number of C 2+ singles, if any. The measured yield of C 2+ singles is therefore due to events in which the H + m of the H + m + C 2+ ion pair was not detected and thus is proportional to 1 - ε r . Methane fragmentation caused by 1 MeV proton impact is used to evaluate directly the recoil ion detection efficiency and to demonstrate the method of deriving the cross sections of all breakup channels. (orig.)

  12. 13 CFR 120.930 - Amount.

    Science.gov (United States)

    2010-01-01

    ... percent of total Project cost plus 100 percent of eligible administrative costs. For good cause shown, SBA... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amount. 120.930 Section 120.930 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan...

  13. 33 CFR 135.203 - Amount required.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Amount required. 135.203 Section 135.203 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

  14. Physician Fee Schedule National Payment Amount File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The significant size of the Physician Fee Schedule Payment Amount File-National requires that database programs (e.g., Access, dBase, FoxPro, etc.) be used to read...

  15. 42 CFR 422.382 - Minimum net worth amount.

    Science.gov (United States)

    2010-10-01

    ... that CMS considers appropriate to reduce, control or eliminate start-up administrative costs. (b) After... section. (c) Calculation of the minimum net worth amount—(1) Cash requirement. (i) At the time of application, the organization must maintain at least $750,000 of the minimum net worth amount in cash or cash...

  16. Directional errors of movements and their correction in a discrete tracking task. [pilot reaction time and sensorimotor performance

    Science.gov (United States)

    Jaeger, R. J.; Agarwal, G. C.; Gottlieb, G. L.

    1978-01-01

    Subjects can correct their own errors of movement more quickly than they can react to external stimuli by using three general categories of feedback: (1) knowledge of results, primarily visually mediated; (2) proprioceptive or kinaesthetic such as from muscle spindles and joint receptors, and (3) corollary discharge or efference copy within the central nervous system. The effects of these feedbacks on simple reaction time, choice reaction time, and error correction time were studied in four normal human subjects. The movement used was plantarflexion and dorsiflexion of the ankle joint. The feedback loops were modified, by changing the sign of the visual display to alter the subject's perception of results, and by applying vibration at 100 Hz simultaneously to both the agonist and antagonist muscles of the ankle joint. The central processing was interfered with when the subjects were given moderate doses of alcohol (blood alcohol concentration levels of up to 0.07%). Vibration and alcohol increase both the simple and choice reaction times but not the error correction time.

  17. Direct Imaging of Transient Fano Resonances in N_{2} Using Time-, Energy-, and Angular-Resolved Photoelectron Spectroscopy.

    Science.gov (United States)

    Eckstein, Martin; Yang, Chung-Hsin; Frassetto, Fabio; Poletto, Luca; Sansone, Giuseppe; Vrakking, Marc J J; Kornilov, Oleg

    2016-04-22

    Autoionizing Rydberg states of molecular N_{2} are studied using time-, energy-, and angular-resolved photoelectron spectroscopy. A femtosecond extreme ultraviolet pulse with a photon energy of 17.5 eV excites the resonance and a subsequent IR pulse ionizes the molecule before the autoionization takes place. The angular-resolved photoelectron spectra depend on pump-probe time delay and allow for the distinguishing of two electronic states contributing to the resonance. The lifetime of one of the contributions is determined to be 14±1  fs, while the lifetime of the other appears to be significantly shorter than the time resolution of the experiment. These observations suggest that the Rydberg states in this energy region are influenced by the effect of interference stabilization and merge into a complex resonance.

  18. Real-Time Evaluation of 26-GBaud PAM-4 Intensity Modulation and Direct Detection Systems for Data-Center Interconnects

    DEFF Research Database (Denmark)

    Eiselt, Nicklas; Griesser, Helmut; Wei, Jinlong

    2016-01-01

    Real-time transmission with 26-GBaud PAM-4 as a promising modulation format for data-center interconnects with operation in C-band is evaluated. For an OSNR penalty below 2 dB a dispersion tolerance of up to 10 km of SSMF is achieved......Real-time transmission with 26-GBaud PAM-4 as a promising modulation format for data-center interconnects with operation in C-band is evaluated. For an OSNR penalty below 2 dB a dispersion tolerance of up to 10 km of SSMF is achieved...

  19. Teacher Directed Design: Content Knowledge, Pedagogy and Assessment under the Nevada K-12 Real-Time Seismic Network

    Science.gov (United States)

    Cantrell, P.; Ewing-Taylor, J.; Crippen, K. J.; Smith, K. D.; Snelson, C. M.

    2004-12-01

    Education professionals and seismologists under the emerging SUN (Shaking Up Nevada) program are leveraging the existing infrastructure of the real-time Nevada K-12 Seismic Network to provide a unique inquiry based science experience for teachers. The concept and effort are driven by teacher needs and emphasize rigorous content knowledge acquisition coupled with the translation of that knowledge into an integrated seismology based earth sciences curriculum development process. We are developing a pedagogical framework, graduate level coursework, and materials to initiate the SUN model for teacher professional development in an effort to integrate the research benefits of real-time seismic data with science education needs in Nevada. A component of SUN is to evaluate teacher acquisition of qualified seismological and earth science information and pedagogy both in workshops and in the classroom and to assess the impact on student achievement. SUN's mission is to positively impact earth science education practices. With the upcoming EarthScope initiative, the program is timely and will incorporate EarthScope real-time seismic data (USArray) and educational materials in graduate course materials and teacher development programs. A number of schools in Nevada are contributing real-time data from both inexpensive and high-quality seismographs that are integrated with Nevada regional seismic network operations as well as the IRIS DMC. A powerful and unique component of the Nevada technology model is that schools can receive "stable" continuous live data feeds from 100's seismograph stations in Nevada, California and world (including live data from Earthworm systems and the IRIS DMC BUD - Buffer of Uniform Data). Students and teachers see their own networked seismograph station within a global context, as participants in regional and global monitoring. The robust real-time Internet communications protocols invoked in the Nevada network provide for local data acquisition

  20. Conditional Dependence between Response Time and Accuracy: An Overview of its Possible Sources and Directions for Distinguishing between Them

    Science.gov (United States)

    Bolsinova, Maria; Tijmstra, Jesper; Molenaar, Dylan; De Boeck, Paul

    2017-01-01

    With the widespread use of computerized tests in educational measurement and cognitive psychology, registration of response times has become feasible in many applications. Considering these response times helps provide a more complete picture of the performance and characteristics of persons beyond what is available based on response accuracy alone. Statistical models such as the hierarchical model (van der Linden, 2007) have been proposed that jointly model response time and accuracy. However, these models make restrictive assumptions about the response processes (RPs) that may not be realistic in practice, such as the assumption that the association between response time and accuracy is fully explained by taking speed and ability into account (conditional independence). Assuming conditional independence forces one to ignore that many relevant individual differences may play a role in the RPs beyond overall speed and ability. In this paper, we critically consider the assumption of conditional independence and the important ways in which it may be violated in practice from a substantive perspective. We consider both conditional dependences that may arise when all persons attempt to solve the items in similar ways (homogeneous RPs) and those that may be due to persons differing in fundamental ways in how they deal with the items (heterogeneous processes). The paper provides an overview of what we can learn from observed conditional dependences. We argue that explaining and modeling these differences in the RPs is crucial to increase both the validity of measurement and our understanding of the relevant RPs. PMID:28261136

  1. Reverse transcriptase real-time PCR for detection and quantification of viable Campylobacter jejuni directly from poultry faecal samples

    DEFF Research Database (Denmark)

    Bui, Thanh Xuan; Wolff, Anders; Madsen, Mogens

    2012-01-01

    Campylobacter spp. is the most common cause of bacterial diarrhoea in humans worldwide. Therefore, rapid and reliable methods fordetection and quantification of this pathogen are required. In this study, we have developed a reverse transcription quantitative real-time PCR(RT-qPCR) for detection a...

  2. Micromechanical Time-Lapse X-ray CT Study of Fatigue Damage in Uni-Directional Fibre Composites

    DEFF Research Database (Denmark)

    Jespersen, Kristine Munk; Lowe, Tristan; Withers, Philip J.

    2015-01-01

    . The geometry of the cut-out is similar to that which will be used in the time-lapse study. As the micro-mechanical damage mechanisms are small features, it is necessary to obtain a high scan resolution which sets a limit to how large the field of view can be. Therefore, it is necessary to perform several scans...

  3. Scalability of Direct Solver for Non-stationary Cahn-Hilliard Simulations with Linearized time Integration Scheme

    KAUST Repository

    Woźniak, M.; Smołka, M.; Cortes, Adriano Mauricio; Paszyński, M.; Schaefer, R.

    2016-01-01

    We study the features of a new mixed integration scheme dedicated to solving the non-stationary variational problems. The scheme is composed of the FEM approximation with respect to the space variable coupled with a 3-leveled time integration scheme

  4. Influence of dwell times on the thermomechanical fatigue behavior of a directionally solidified Ni-base superalloy

    Czech Academy of Sciences Publication Activity Database

    Guth, S.; Petráš, Roman; Škorík, Viktor; Kruml, Tomáš; Man, Jiří; Lang, K. H.; Polák, Jaroslav

    2015-01-01

    Roč. 80, NOV (2015), s. 426-433 ISSN 0142-1123 R&D Projects: GA MŠk(CZ) EE2.3.30.0063 Institutional support: RVO:68081723 Keywords : Nickel base superalloy * Thermomechanical fatigue * Dwell time * Lifetime behavior * Damage mechanisms Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 2.162, year: 2015

  5. The role and timing of palliative medicine consultation for women with gynecologic malignancies: association with end of life interventions and direct hospital costs.

    Science.gov (United States)

    Nevadunsky, Nicole S; Gordon, Sharon; Spoozak, Lori; Van Arsdale, Anne; Hou, Yijuan; Klobocista, Merieme; Eti, Serife; Rapkin, Bruce; Goldberg, Gary L

    2014-01-01

    Aggressive care interventions at the end of life (ACE) are reported metrics of sub-optimal quality of end of life care that are modifiable by palliative medicine consultation. Our objective was to evaluate the association of inpatient palliative medicine consultation with ACE scores and direct inpatient hospital costs of patients with gynecologic malignancies. A retrospective review of medical records of the past 100 consecutive patients who died from their primary gynecologic malignancies at a single institution was performed. Timely palliative medicine consultation was defined as exposure to inpatient consultation ≥ 30 days before death. Metrics utilized to tabulate ACE scores were ICU admission, hospital admission, emergency room visit, death in an acute care setting, chemotherapy at the end of life, and hospice admission Whitney U, Kaplan-Meier, and Student's T testing. 49% of patients had a palliative medicine consultation and 18% had timely consultation. Median ACE score for patients with timely palliative medicine consultation was 0 (range 0-3) versus 2 (range 0-6) p=0.025 for patients with untimely/no consultation. Median inpatient direct costs for the last 30 days of life were lower for patients with timely consultation, $0 (range 0-28,019) versus untimely, $7729 (0-52,720), p=0.01. Timely palliative medicine consultation was associated with lower ACE scores and direct hospital costs. Prospective evaluation is needed to validate the impact of palliative medicine consultation on quality of life and healthcare costs. © 2013. Published by Elsevier Inc. All rights reserved.

  6. Device for the acquisition and visualization in real time of the velocity and direction of wind in a radiological post stage

    International Nuclear Information System (INIS)

    Ledo P, L.M.; Guibert G, R.; Dominguez L, O.; Alonso A, D.; Ramos V, E.O.

    2006-01-01

    The work shows the development, construction and post stage of a device dedicated to the acquisition and transmission in real time of the information on the behavior of the meteorological variables: velocity and wind direction. It is introduced for the first time in an observation position the automatic monitoring, in real time, using the tools that it offers the digitalisation of the information and the computation. The obtained data are registered in a PC, its are visualized appropriately and can be objects of later analysis. It was developed the application program Autoclima for such purpose. (Author)

  7. Identification of Blood Culture Isolates Directly from Positive Blood Cultures by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and a Commercial Extraction System: Analysis of Performance, Cost, and Turnaround Time

    OpenAIRE

    Lagacé-Wiens, Philippe R. S.; Adam, Heather J.; Karlowsky, James A.; Nichol, Kimberly A.; Pang, Paulette F.; Guenther, Jodi; Webb, Amanda A.; Miller, Crystal; Alfa, Michelle J.

    2012-01-01

    Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry represents a revolution in the rapid identification of bacterial and fungal pathogens in the clinical microbiology laboratory. Recently, MALDI-TOF has been applied directly to positive blood culture bottles for the rapid identification of pathogens, leading to reductions in turnaround time and potentially beneficial patient impacts. The development of a commercially available extraction kit (Bruker Sepsit...

  8. Direct Heat

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P J

    1990-01-01

    Potential resources and applications of earth heat in the form of geothermal energy are large. United States direct uses amount to 2,100 MWt thermal and worldwide 8,850 MWt above a reference temperature of 35 degrees Celsius. Space and district heating are the major direct uses of geothermal energy. Equipment employed in direct use projects is of standard manufacture and includes downhole and circulation pumps, transmission and distribution pipelines, heat exchangers and convectors, heat pumps and chillers. Direct uses of earth heat discussed are space and district heating, greenhouse heating and fish farming, process and industrial applications. The economic feasibility of direct use projects is governed by site specific factors such as location of user and resource, resource quality, system load factor and load density, as well as financing. Examples are presented of district heating in Klamath Falls, and Elko. Further developments of direct uses of geothermal energy will depend on matching user needs to the resource, and improving load factors and load density.

  9. Radiculography with reduced amounts of contrast medium

    International Nuclear Information System (INIS)

    Signorini, E.; Caputo, N.; Chiurulla, C.; Ciorba, E.; Pelliccioli, G.P.; Cianciulli, E.

    1984-01-01

    Because of the frequency and seriousness of side effects observed after radiculography, due to, among the other things, the amount of contrast medium, the authors describe a method that gives diagnostically satisfactory results using a low dose of contrast and a tangent-beam technique. Among 106 patients undergoing radiculography with a tangent-beam technique and Iopamidol, only 4 developed mild side effects, namely headache in three cases and headache with nausea in one. (Author)

  10. Type of oral solid medication packaging and medication preparation time in nursing homes: A direct observation study.

    Science.gov (United States)

    Cready, C M; Hudson, C; Dreyer, K

    2017-12-01

    Medication administration is a substantial portion of the workday in nursing homes, with the medication preparation step being the most time-consuming. However, little is known about how medication preparation time is affected by the type of packaging used for oral solid medications (ie, tablets/capsules). We examined the effects of two types of packaging. As fewer steps are associated with strip packaging compared to bingo card packaging, we hypothesized that the increase in medication preparation seconds per resident with each additional oral solid medication would be smaller when strip packaging was used. A total of 430 medication preparations conducted by eight nurses during the regularly scheduled morning medication administration period in two nursing homes-using strip packaging and bingo card packaging, respectively-were observed. Each medication preparation observation was matched to its corresponding medication administration record and observations averaged across resident. Using the resident sample (N=149), we estimated three regression models (adjusting the standard errors for the clustering of resident by nurse). The first model regressed medication preparation seconds on the number of oral solid medications. The second model added the type of packaging used and the control variables (type of unit [long-term care, post-acute care], the number of one-half pills and the dosage form diversity in the preparation). To test our hypothesis, the third model added an interaction term between the number of oral solid medications and the type of packaging used. As hypothesized, all else equal, the number of oral solid medications tended to increase medication preparation time per resident in both nursing homes, but the increase was smaller in the strip packaging nursing home (Ppackaging nursing home increased medication preparation by an average of 13 seconds (b=13.077), whereas each oral solid medication administered in the strip packaging nursing home

  11. Amount of trace elements in marine cephalopods

    International Nuclear Information System (INIS)

    Ueda, Taiji; Nakahara, Motokazu; Ishii, Toshiaki; Suzuki, Yuzuru; Suzuki, Hamaji.

    1979-01-01

    For the estimation of internal radiation to human beings, the amounts of Mn, Fe, Cu, Zn, Co and Cs in 5 species of marine cephalopods were determined by atomic absorption spectrophotometry and neutron activation analysis, and then the concentration factors were calculated. The average amount and the concentration factor of the elements in the edible parts (mantle, arms and tentacles) of cephalopods are as follows: 0.14 mg, 2 x 10 2 for Mn, 1.8 mg, 2 x 10 2 for Fe, 2.0 mg, 7 x 10 2 for Cu, 12.2 mg, 1 x 10 3 for Zn, 5.3 μg, 6 x 10 1 for Co and 3.4 μg, 7 for Cs. The amounts of Fe, Co, Cu and Zn in the liver and the branchial heart were much higher than those in the edible parts, although those of Cs and Mn were almost the same. The Co content in the visceral organs of O. Vulgaris showed extremely high value, particularly in the branchial heart. (author)

  12. Stability of formation control using a consensus protocol under directed communications with two time delays and delay scheduling

    Science.gov (United States)

    Cepeda-Gomez, Rudy; Olgac, Nejat

    2016-01-01

    We consider a linear algorithm to achieve formation control in a group of agents which are driven by second-order dynamics and affected by two rationally independent delays. One of the delays is in the position and the other in the velocity information channels. These delays are taken as constant and uniform throughout the system. The communication topology is assumed to be directed and fixed. The formation is attained by adding a supplementary control term to the stabilising consensus protocol. In preparation for the formation control logic, we first study the stability of the consensus, using the recent cluster treatment of characteristic roots (CTCR) paradigm. This effort results in a unique depiction of the non-conservative stability boundaries in the domain of the delays. However, CTCR requires the knowledge of the potential stability switching loci exhaustively within this domain. The creation of these loci is done in a new surrogate coordinate system, called the 'spectral delay space (SDS)'. The relative stability is also investigated, which has to do with the speed of reaching consensus. This step leads to a paradoxical control design concept, called the 'delay scheduling', which highlights the fact that the group behaviour may be enhanced by increasing the delays. These steps lead to a control strategy to establish a desired group formation that guarantees spacing among the agents. Example case studies are presented to validate the underlying analytical derivations.

  13. Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry.

    Science.gov (United States)

    Li, Xianjiang; Wang, Xin; Ma, Wen; Ai, Wanpeng; Bai, Yu; Ding, Li; Liu, Huwei

    2017-04-01

    Glycosides are a kind of highly important natural aromatic precursors in tobacco leaves. In this study, a novel HKUST-1-coated monolith dip-it sampler was designed for the fast and sensitive analysis of trace glycosides using direct analysis in real-time mass spectrometry. This device was prepared in two steps: in situ polymerization of monolith in a glass capillary of dip-it and layer-by-layer growth of HKUST-1 on the surface of monolith. Sufficient extraction was realized by immersing the tip to solution and in situ desorption was carried out by plasma direct analysis in real time. Compared with traditional solid-phase microextraction protocols, sample desorption was not needed anymore, and only extraction conditions were needed to be optimized in this method, including the gas temperature of direct analysis in real time, extraction time, and CH 3 COONH 4 additive concentration. This method enabled the simultaneous detection of six kinds of glycosides with the limits of detection of 0.02-0.05 μg/mL and the linear ranges covering two orders of magnitude with the limits of quantitation of 0.05-0.1 μg/mL. Moreover, the developed method was applied for the glycosides analysis of three tobacco samples, which only took about 2 s for every sample. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. The investigation and implementation of real-time face pose and direction estimation on mobile computing devices

    Science.gov (United States)

    Fu, Deqian; Gao, Lisheng; Jhang, Seong Tae

    2012-04-01

    The mobile computing device has many limitations, such as relative small user interface and slow computing speed. Usually, augmented reality requires face pose estimation can be used as a HCI and entertainment tool. As far as the realtime implementation of head pose estimation on relatively resource limited mobile platforms is concerned, it is required to face different constraints while leaving enough face pose estimation accuracy. The proposed face pose estimation method met this objective. Experimental results running on a testing Android mobile device delivered satisfactory performing results in the real-time and accurately.

  15. Characterization of cryogenic direct-drive ICF targets during layering studies and just prior to shot time

    Energy Technology Data Exchange (ETDEWEB)

    Edgell, D.H.; Seka, W.; Craxton, R.S.; Elasky, L.M.; Harding, D.R.; Keck, R.L.; Lund, L.D.; Wittman, M.D. [Rochester Univ., Lab. for Laser Energetics, NY (United States)

    2006-06-15

    The characterization of OMEGA cryogenic targets is based on shadow-graphs obtained from multiple angular views taken with the target in the layering sphere. The D{sub 2} ice has been observed to re-layer during slow rotations, leading to procedural changes that avoid re-layering thus ensuring high-quality, spherical-harmonic, 3-dimensional ice layer reconstructions. Shadow-grams taken inside the target chamber within 20 ms of shot time have verified that the ice layers remain preserved during the transport. (authors)

  16. Identification of blood culture isolates directly from positive blood cultures by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and a commercial extraction system: analysis of performance, cost, and turnaround time.

    Science.gov (United States)

    Lagacé-Wiens, Philippe R S; Adam, Heather J; Karlowsky, James A; Nichol, Kimberly A; Pang, Paulette F; Guenther, Jodi; Webb, Amanda A; Miller, Crystal; Alfa, Michelle J

    2012-10-01

    Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry represents a revolution in the rapid identification of bacterial and fungal pathogens in the clinical microbiology laboratory. Recently, MALDI-TOF has been applied directly to positive blood culture bottles for the rapid identification of pathogens, leading to reductions in turnaround time and potentially beneficial patient impacts. The development of a commercially available extraction kit (Bruker Sepsityper) for use with the Bruker MALDI BioTyper has facilitated the processing required for identification of pathogens directly from positive from blood cultures. We report the results of an evaluation of the accuracy, cost, and turnaround time of this method for 61 positive monomicrobial and 2 polymicrobial cultures representing 26 species. The Bruker MALDI BioTyper with the Sepsityper gave a valid (score, >1.7) identification for 85.2% of positive blood cultures with no misidentifications. The mean reduction in turnaround time to identification was 34.3 h (P MALDI-TOF was used for all blood cultures and 26.5 h in a more practical setting where conventional identification or identification from subcultures was required for isolates that could not be directly identified by MALDI-TOF. Implementation of a MALDI-TOF-based identification system for direct identification of pathogens from blood cultures is expected to be associated with a marginal increase in operating costs for most laboratories. However, the use of MALDI-TOF for direct identification is accurate and should result in reduced turnaround time to identification.

  17. Characterization of Leucaena (Leucaena leucephala) oil by direct analysis in real time (DART) ion source and gas chromatography

    International Nuclear Information System (INIS)

    Alam, M.; Alandis, N.M.; Sharmin, E.; Ahmad, N.; Alrayes, B.F.; Ali, D.

    2017-01-01

    For the first time, we report the characterization of triacylglycerols and fatty acids in Leucaena (Leucaena leucephala) oil [LUCO], an unexplored nontraditional non-medicinal plant belonging to the family Fabaceae. LUCO was converted to fatty acid methyl esters (FAMEs). We analyzed the triacylglycerols (TAGs) of pure LUCO and their FAMEs by time-of-flight mass spectrometry (TOF-MS) followed by multivariate analysis for discrimination among the FAMEs. Our investigations for the analysis of LUCO samples represent noble features of glycerides. A new type of ion source, coupled with high-resolution TOF-MS was applied for the comprehensive analysis of triacylglycerols. The composition of fatty acid based LUCO oil was studied using Gas Chromatography (GC-FID). The major fatty acid components of LUCO oil are linoleic acid (52.08%) oleic acid (21.26%), palmitic acid (7.91%) and stearic acid (6.01%). A metal analysis in LUCO was done by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The structural elucidation and thermal stability of LUCO were studied by FT-IR, 1H NMR, 13C NMR spectroscopic techniques and TGA-DSC, respectively. We also measured the cytotoxicity of LUCO [es

  18. Experimental investigation of timed manifold injection of acetylene in direct injection diesel engine in dual fuel mode

    International Nuclear Information System (INIS)

    Lakshmanan, T.; Nagarajan, G.

    2010-01-01

    The increase in demand and decrease in availability of fossil fuels with more stringent emission norms have led to research in finding an alternative fuel for internal combustion (IC) engines. Among the alternative fuels, gaseous fuels find a great potential. The gaseous fuel taken up for the present study is acetylene, which possesses excellent combustion properties. Preignition is the major problem with this fuel. In the present study, timed manifold injection technique is adopted to induct the fuel into the IC engine. A four-stroke, 4.4 kW diesel engine is selected, with slight modification in intake manifold for holding the gas injector, which is controlled by an electronic control unit (ECU). By using an ECU, an optimized injection timing of 10 o after top dead center and 90 o crank angle duration are arrived. At this condition, experiments were conducted for the various gas flow rates of 110 g/s, 180 g/s and 240 g/s. The performance was nearer to diesel at full load. Oxides of nitrogen, hydrocarbon and carbon monoxide emission decreased due to lean operation with marginal increase in smoke emission. To conclude, a safe operation of acetylene replacement up to 24% was possible with reduction in emission parameters.

  19. Direct atomic fabrication and dopant positioning in Si using electron beams with active real-time image-based feedback

    Science.gov (United States)

    Jesse, Stephen; Hudak, Bethany M.; Zarkadoula, Eva; Song, Jiaming; Maksov, Artem; Fuentes-Cabrera, Miguel; Ganesh, Panchapakesan; Kravchenko, Ivan; Snijders, Panchapakesan C.; Lupini, Andrew R.; Borisevich, Albina Y.; Kalinin, Sergei V.

    2018-06-01

    Semiconductor fabrication is a mainstay of modern civilization, enabling the myriad applications and technologies that underpin everyday life. However, while sub-10 nanometer devices are already entering the mainstream, the end of the Moore’s law roadmap still lacks tools capable of bulk semiconductor fabrication on sub-nanometer and atomic levels, with probe-based manipulation being explored as the only known pathway. Here we demonstrate that the atomic-sized focused beam of a scanning transmission electron microscope can be used to manipulate semiconductors such as Si on the atomic level, inducing growth of crystalline Si from the amorphous phase, reentrant amorphization, milling, and dopant front motion. These phenomena are visualized in real-time with atomic resolution. We further implement active feedback control based on real-time image analytics to automatically control the e-beam motion, enabling shape control and providing a pathway for atom-by-atom correction of fabricated structures in the near future. These observations open a new epoch for atom-by-atom manufacturing in bulk, the long-held dream of nanotechnology.

  20. Direct Observation of Long-Range Transport Using Continuously Sounding Balloons and Near-Real-Time Trajectory Modeling

    Science.gov (United States)

    Voss, P. B.; Zaveri, R. A.; Berkowitz, C. M.

    2009-12-01

    Controlled Meteorological (CMET) balloons have been used in several recent studies to measure long-range transport over periods as long as 30 hours and distances up to 1000 kilometers. By repeatedly performing shallow soundings as they drift, CMET balloons can quantify evolving atmospheric structure, mixing events, shear advection, and dispersion during transport. In addition, the quasi-Lagrangian wind profiles can be used to drive a multi-layer trajectory model in which the advected air parcels follow the underlying terrain, or are constrained by altitude, potential temperature, or tracer concentration. Data from a coordinated balloon-aircraft study of long range transport over Texas (SETTS 2005) show that the reconstructed trajectories accurately track residual-layer urban outflow (and at times even its fine-scale structure) over distances of many hundreds of kilometers. The reconstructed trajectories and evolving profile visualizations are increasingly being made available in near-real time during balloon flights, supporting data-driven flight planning and sophisticated process studies relevant to atmospheric chemistry and climate. Multilayer trajectories (black grids) derived from CMET balloon flight paths (grey lines) for a transport event across Texas in 2005.

  1. Direct atomic fabrication and dopant positioning in Si using electron beams with active real-time image-based feedback.

    Science.gov (United States)

    Jesse, Stephen; Hudak, Bethany M; Zarkadoula, Eva; Song, Jiaming; Maksov, Artem; Fuentes-Cabrera, Miguel; Ganesh, Panchapakesan; Kravchenko, Ivan; Snijders, Panchapakesan C; Lupini, Andrew R; Borisevich, Albina Y; Kalinin, Sergei V

    2018-06-22

    Semiconductor fabrication is a mainstay of modern civilization, enabling the myriad applications and technologies that underpin everyday life. However, while sub-10 nanometer devices are already entering the mainstream, the end of the Moore's law roadmap still lacks tools capable of bulk semiconductor fabrication on sub-nanometer and atomic levels, with probe-based manipulation being explored as the only known pathway. Here we demonstrate that the atomic-sized focused beam of a scanning transmission electron microscope can be used to manipulate semiconductors such as Si on the atomic level, inducing growth of crystalline Si from the amorphous phase, reentrant amorphization, milling, and dopant front motion. These phenomena are visualized in real-time with atomic resolution. We further implement active feedback control based on real-time image analytics to automatically control the e-beam motion, enabling shape control and providing a pathway for atom-by-atom correction of fabricated structures in the near future. These observations open a new epoch for atom-by-atom manufacturing in bulk, the long-held dream of nanotechnology.

  2. A novel method for sampling the suspended sediment load in the tidal environment using bi-directional time-integrated mass-flux sediment (TIMS) samplers

    Science.gov (United States)

    Elliott, Emily A.; Monbureau, Elaine; Walters, Glenn W.; Elliott, Mark A.; McKee, Brent A.; Rodriguez, Antonio B.

    2017-12-01

    Identifying the source and abundance of sediment transported within tidal creeks is essential for studying the connectivity between coastal watersheds and estuaries. The fine-grained suspended sediment load (SSL) makes up a substantial portion of the total sediment load carried within an estuarine system and efficient sampling of the SSL is critical to our understanding of nutrient and contaminant transport, anthropogenic influence, and the effects of climate. Unfortunately, traditional methods of sampling the SSL, including instantaneous measurements and automatic samplers, can be labor intensive, expensive and often yield insufficient mass for comprehensive geochemical analysis. In estuaries this issue is even more pronounced due to bi-directional tidal flow. This study tests the efficacy of a time-integrated mass sediment sampler (TIMS) design, originally developed for uni-directional flow within the fluvial environment, modified in this work for implementation the tidal environment under bi-directional flow conditions. Our new TIMS design utilizes an 'L' shaped outflow tube to prevent backflow, and when deployed in mirrored pairs, each sampler collects sediment uniquely in one direction of tidal flow. Laboratory flume experiments using dye and particle image velocimetry (PIV) were used to characterize the flow within the sampler, specifically, to quantify the settling velocities and identify stagnation points. Further laboratory tests of sediment indicate that bidirectional TIMS capture up to 96% of incoming SSL across a range of flow velocities (0.3-0.6 m s-1). The modified TIMS design was tested in the field at two distinct sampling locations within the tidal zone. Single-time point suspended sediment samples were collected at high and low tide and compared to time-integrated suspended sediment samples collected by the bi-directional TIMS over the same four-day period. Particle-size composition from the bi-directional TIMS were representative of the array of

  3. The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile Hormone Signaling

    Science.gov (United States)

    Chaieb, Leila; Koyama, Takashi; Sarwar, Prioty; Mirth, Christen K.; Smith, Wendy A.; Suzuki, Yuichiro

    2014-01-01

    Although endocrine changes are known to modulate the timing of major developmental transitions, the genetic mechanisms underlying these changes remain poorly understood. In insects, two developmental hormones, juvenile hormone (JH) and ecdysteroids, are coordinated with each other to induce developmental changes associated with metamorphosis. However, the regulation underlying the coordination of JH and ecdysteroid synthesis remains elusive. Here, we examined the function of a homolog of the vertebrate POU domain protein, Ventral veins lacking (Vvl)/Drifter, in regulating both of these hormonal pathways in the red flour beetle, Tribolium castaneum (Tenebrionidae). RNA interference-mediated silencing of vvl expression led to both precocious metamorphosis and inhibition of molting in the larva. Ectopic application of a JH analog on vvl knockdown larvae delayed the onset of metamorphosis and led to a prolonged larval stage, indicating that Vvl acts upstream of JH signaling. Accordingly, vvl knockdown also reduced the expression of a JH biosynthesis gene, JH acid methyltransferase 3 (jhamt3). In addition, ecdysone titer and the expression of the ecdysone response gene, hormone receptor 3 (HR3), were reduced in vvl knockdown larvae. The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources. Injection of 20-hydroxyecdysone (20E) into vvl knockdown larvae could restore the expression of HR3 although molting was never restored. These findings suggest that Vvl coordinates both JH and ecdysteroid biosynthesis as well as molting behavior to influence molting and the timing of metamorphosis. Thus, in both vertebrates and insects, POU factors modulate the production of major neuroendocrine regulators during sexual maturation. PMID:24945490

  4. Gigahertz repetition rate, sub-femtosecond timing jitter optical pulse train directly generated from a mode-locked Yb:KYW laser.

    Science.gov (United States)

    Yang, Heewon; Kim, Hyoji; Shin, Junho; Kim, Chur; Choi, Sun Young; Kim, Guang-Hoon; Rotermund, Fabian; Kim, Jungwon

    2014-01-01

    We show that a 1.13 GHz repetition rate optical pulse train with 0.70 fs high-frequency timing jitter (integration bandwidth of 17.5 kHz-10 MHz, where the measurement instrument-limited noise floor contributes 0.41 fs in 10 MHz bandwidth) can be directly generated from a free-running, single-mode diode-pumped Yb:KYW laser mode-locked by single-wall carbon nanotube-coated mirrors. To our knowledge, this is the lowest-timing-jitter optical pulse train with gigahertz repetition rate ever measured. If this pulse train is used for direct sampling of 565 MHz signals (Nyquist frequency of the pulse train), the jitter level demonstrated would correspond to the projected effective-number-of-bit of 17.8, which is much higher than the thermal noise limit of 50 Ω load resistance (~14 bits).

  5. 2D time-of-flight MR angiography using concatenated saturation bands for determining direction of flow in the intracranial vessels

    International Nuclear Information System (INIS)

    Nesbit, G.M.; DeMarco, J.K.

    1997-01-01

    We prospectively studied 15 patients to assess 2D time-of-flight (TOF) magnetic resonance angiography (MRA) with concatenated saturation bands for determining the direction of intracranial blood flow. This MRA sequence was compared to T2-weighted spin-echo MRI, 3D-TOF MRA, and intra-arterial angiography (IAA) as regards demonstration of vessels and determination of the direction of flow in the circle of Willis and its branches. The 2D-TOF MRA sequence demonstrated flow in 98.5 % vessel segments identified on IAA, 3D-TOF demonstrating 92 % and spin-echo images 77 %. The direction of flow shown on the 2D-TOF sequence was correct in 94 % when compared to conventional angiography, the remaining six segments not demonstrating flow. In ten patients, the flow abnormalities demonstrated by this MRA technique provided clinical information similar to that of conventional angiography in nine, but it was incomplete in three, and misleading in one. Slow retrograde flow in ophthalmic artery collaterals and differentiation of arteries and veins presented some problems. 2D-TOF MRA with concatenated saturation bands provides flow direction information using widely available, easily applicable TOF techniques, and can be a useful adjunct to MRI and MRA if information on flow direction is needed. (orig.). With 5 figs., 3 tabs

  6. A real-time comparison between direct control, sequential pattern recognition control and simultaneous pattern recognition control using a Fitts' law style assessment procedure.

    Science.gov (United States)

    Wurth, Sophie M; Hargrove, Levi J

    2014-05-30

    Pattern recognition (PR) based strategies for the control of myoelectric upper limb prostheses are generally evaluated through offline classification accuracy, which is an admittedly useful metric, but insufficient to discuss functional performance in real time. Existing functional tests are extensive to set up and most fail to provide a challenging, objective framework to assess the strategy performance in real time. Nine able-bodied and two amputee subjects gave informed consent and participated in the local Institutional Review Board approved study. We designed a two-dimensional target acquisition task, based on the principles of Fitts' law for human motor control. Subjects were prompted to steer a cursor from the screen center of into a series of subsequently appearing targets of different difficulties. Three cursor control systems were tested, corresponding to three electromyography-based prosthetic control strategies: 1) amplitude-based direct control (the clinical standard of care), 2) sequential PR control, and 3) simultaneous PR control, allowing for a concurrent activation of two degrees of freedom (DOF). We computed throughput (bits/second), path efficiency (%), reaction time (second), and overshoot (%)) and used general linear models to assess significant differences between the strategies for each metric. We validated the proposed methodology by achieving very high coefficients of determination for Fitts' law. Both PR strategies significantly outperformed direct control in two-DOF targets and were more intuitive to operate. In one-DOF targets, the simultaneous approach was the least precise. The direct control was efficient in one-DOF targets but cumbersome to operate in two-DOF targets through a switch-depended sequential cursor control. We designed a test, capable of comprehensively describing prosthetic control strategies in real time. When implemented on control subjects, the test was able to capture statistically significant differences (p

  7. Optimizing a neutron-beam focusing device for the direct geometry time-of-flight spectrometer TOFTOF at the FRM II reactor source

    DEFF Research Database (Denmark)

    Rasmussen, N. G.; Simeoni, G. G.; Lefmann, K.

    2016-01-01

    A dedicated beam-focusing device has been designed for the direct geometry thermal-cold neutron time-of-flight spectrometer TOFTOF at the neutron facility FRM II (Garching, Germany). The prototype, based on the compressed Archimedes' mirror concept, benefits from the adaptive-optics technology (a...... than 3.5 would have only marginal influence on the optimal behaviour, whereas comparable spectrometers could take advantage of longer focusing segments, with particular impact for the thermal region of the neutron spectrum....

  8. Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Direct Bacterial Identification from Positive Blood Culture Pellets ▿

    OpenAIRE

    Prod'hom, Guy; Bizzini, Alain; Durussel, Christian; Bille, Jacques; Greub, Gilbert

    2010-01-01

    An ammonium chloride erythrocyte-lysing procedure was used to prepare a bacterial pellet from positive blood cultures for direct matrix-assisted laser desorption-ionization time of flight (MALDI-TOF) mass spectrometry analysis. Identification was obtained for 78.7% of the pellets tested. Moreover, 99% of the MALDI-TOF identifications were congruent at the species level when considering valid scores. This fast and accurate method is promising.

  9. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for direct bacterial identification from positive blood culture pellets.

    Science.gov (United States)

    Prod'hom, Guy; Bizzini, Alain; Durussel, Christian; Bille, Jacques; Greub, Gilbert

    2010-04-01

    An ammonium chloride erythrocyte-lysing procedure was used to prepare a bacterial pellet from positive blood cultures for direct matrix-assisted laser desorption-ionization time of flight (MALDI-TOF) mass spectrometry analysis. Identification was obtained for 78.7% of the pellets tested. Moreover, 99% of the MALDI-TOF identifications were congruent at the species level when considering valid scores. This fast and accurate method is promising.

  10. Comparing fixed-amount and progressive-amount DRO Schedules for tic suppression in youth with chronic tic disorders.

    Science.gov (United States)

    Capriotti, Matthew R; Turkel, Jennifer E; Johnson, Rachel A; Espil, Flint M; Woods, Douglas W

    2017-01-01

    Chronic tic disorders (CTDs) involve motor and/or vocal tics that often cause substantial distress and impairment. Differential reinforcement of other behavior (DRO) schedules of reinforcement produce robust, but incomplete, reductions in tic frequency in youth with CTDs; however, a more robust reduction may be needed to affect durable clinical change. Standard, fixed-amount DRO schedules have not commonly yielded such reductions, so we evaluated a novel, progressive-amount DRO schedule, based on its ability to facilitate sustained abstinence from functionally similar behaviors. Five youth with CTDs were exposed to periods of baseline, fixed-amount DRO (DRO-F), and progressive-amount DRO (DRO-P). Both DRO schedules produced decreases in tic rate and increases in intertic interval duration, but no systematic differences were seen between the two schedules on any dimension of tic occurrence. The DRO-F schedule was generally preferred to the DRO-P schedule. Possible procedural improvements and other future directions are discussed. © 2016 Society for the Experimental Analysis of Behavior.

  11. Plant traits correlated with generation time directly affect inbreeding depression and mating system and indirectly genetic structure

    Directory of Open Access Journals (Sweden)

    Hardy Olivier J

    2009-07-01

    differences in stature, as proposed earlier, but rather to differences in generation time. Conclusion Plant traits correlated with generation time affect both inbreeding depression and mating system. These in turn modify genetic drift and gene flow and ultimately genetic structure.

  12. Direct Observations of Parenting and Real-time Negative Affect among Adolescent Smokers and Non-Smokers

    Science.gov (United States)

    Richmond, Melanie J.; Mermelstein, Robin J.; Wakschlag, Lauren S.

    2012-01-01

    Objective This longitudinal study examined how observations of parental general communication style and control with their adolescents predicted changes in negative affect over time for adolescent smokers and non-smokers. Method Participants were 9th and 10th grade adolescents (N = 111; 56.8% female) who had all experimented with cigarettes and were thus at risk for continued smoking and escalation; 36% of these adolescents (n = 40) had smoked in the past month at baseline and were considered smokers in the present analyses. Adolescents participated separately with mothers and fathers in observed parent-adolescent problem-solving discussions to assess parenting at baseline. Adolescent negative affect was assessed at baseline, 6- and 24-months via ecological momentary assessment. Results Among both smoking and non-smoking adolescents, escalating negative affect significantly increased risk for future smoking. Higher quality maternal and paternal communication predicted a decline in negative affect over 1.5 years for adolescent smokers but was not related to negative affect for non-smokers. Controlling maternal, but not paternal, parenting predicted escalation in negative affect for all adolescents. Conclusions Findings suggest that reducing negative affect among experimenting youth can reduce risk for smoking escalation. Therefore, family-based prevention efforts for adolescent smoking escalation might consider parental general communication style and control as intervention targets. However, adolescent smoking status and parent gender may moderate these effects. PMID:23153193

  13. On the effect of injection timing on the ignition of lean PRF/air/EGR mixtures under direct dual fuel stratification conditions

    KAUST Repository

    Luong, Minh Bau; Sankaran, Ramanan; Yu, Gwang Hyeon; Chung, Suk-Ho; Yoo, Chun Sang

    2017-01-01

    The ignition characteristics of lean primary reference fuel (PRF)/air/exhaust gas recirculation (EGR) mixture under reactivity-controlled compression ignition (RCCI) and direct duel fuel stratification (DDFS) conditions are investigated by 2-D direct numerical simulations (DNSs) with a 116-species reduced chemistry of the PRF oxidation. The 2-D DNSs of the DDFS combustion are performed by varying the injection timing of iso-octane (i-C8H18) with a pseudo-iso-octane (PC8H18) model together with a novel compression heating model to account for the compression heating and expansion cooling effects of the piston motion in an engine cylinder. The PC8H18 model is newly developed to mimic the timing, duration, and cooling effects of the direct injection of i-C8H18 onto a premixed background charge of PRF/air/EGR mixture with composition inhomogeneities. It is found that the RCCI combustion exhibits a very high peak heat release rate (HRR) with a short combustion duration due to the predominance of the spontaneous ignition mode of combustion. However, the DDFS combustion has much lower peak HRR and longer combustion duration regardless of the fuel injection timing compared to those of the RCCI combustion, which is primarily attributed to the sequential injection of i-C8H18. It is also found that the ignition delay of the DDFS combustion features a non-monotonic behavior with increasing fuel-injection timing due to the different effect of fuel evaporation on the low-, intermediate-, and high-temperature chemistry of the PRF oxidation. The budget and Damköhler number analyses verify that although a mixed combustion mode of deflagration and spontaneous ignition exists during the early phase of the DDFS combustion, the spontaneous ignition becomes predominant during the main combustion, and hence, the spread-out of heat release rate in the DDFS combustion is mainly governed by the direct injection process of i-C8H18. Finally, a misfire is observed for the DDFS combustion when

  14. On the effect of injection timing on the ignition of lean PRF/air/EGR mixtures under direct dual fuel stratification conditions

    KAUST Repository

    Luong, Minh Bau

    2017-06-10

    The ignition characteristics of lean primary reference fuel (PRF)/air/exhaust gas recirculation (EGR) mixture under reactivity-controlled compression ignition (RCCI) and direct duel fuel stratification (DDFS) conditions are investigated by 2-D direct numerical simulations (DNSs) with a 116-species reduced chemistry of the PRF oxidation. The 2-D DNSs of the DDFS combustion are performed by varying the injection timing of iso-octane (i-C8H18) with a pseudo-iso-octane (PC8H18) model together with a novel compression heating model to account for the compression heating and expansion cooling effects of the piston motion in an engine cylinder. The PC8H18 model is newly developed to mimic the timing, duration, and cooling effects of the direct injection of i-C8H18 onto a premixed background charge of PRF/air/EGR mixture with composition inhomogeneities. It is found that the RCCI combustion exhibits a very high peak heat release rate (HRR) with a short combustion duration due to the predominance of the spontaneous ignition mode of combustion. However, the DDFS combustion has much lower peak HRR and longer combustion duration regardless of the fuel injection timing compared to those of the RCCI combustion, which is primarily attributed to the sequential injection of i-C8H18. It is also found that the ignition delay of the DDFS combustion features a non-monotonic behavior with increasing fuel-injection timing due to the different effect of fuel evaporation on the low-, intermediate-, and high-temperature chemistry of the PRF oxidation. The budget and Damköhler number analyses verify that although a mixed combustion mode of deflagration and spontaneous ignition exists during the early phase of the DDFS combustion, the spontaneous ignition becomes predominant during the main combustion, and hence, the spread-out of heat release rate in the DDFS combustion is mainly governed by the direct injection process of i-C8H18. Finally, a misfire is observed for the DDFS combustion when

  15. Can the Earth’s harmonic spectrum be derived directly from the stochastic inversion of global travel-time data?

    Directory of Open Access Journals (Sweden)

    Steve Della Mora

    2015-03-01

    Full Text Available A set of seismic observations which all sample the same structure in the same way should have zero variance. This is naturally the case if all sources are in the same place, and the data are recorded by the same station. If sources and/or receivers are not in the same place, but close to one another, variance will generally be nonzero, but small. Variance might become large if the sampled region of the Earth contains heterogeneities whose spatial wavelength is comparable to the distances between sources and between receivers (and thus between the corresponding ray paths. The travel-time variance of a “bundle” of seismic rays thus reflects the degree of complexity of the sampled region of the medium. We apply this simple principle to real seismic databases, attempting to constrain the spherical harmonic spectrum of Earth’s structure without having to derive a tomographic model. This results in a reduction of the dimensionality of the solution space, and hence of computational costs. This approach allows to constrain the statistical properties, rather than exact geographic locations of structural features; knowing the statistics of Earth’s structure is most valuable for many fundamental geodynamic questions. We follow an earlier study by Gudmundsson et al. [1990] to find an approximate analytical relationship between averaged variance and harmonic spectrum; this allows us to determine the latter from a measurement of the former via a linear least squares inversion. Our analysis shows that the variance of ray bundles associated with large geographic extent of source/receiver bins is sensitive to low-degree spectral power, and vice-versa for small bins/high harmonic degrees. The method is accordingly ineffective at very low harmonic degrees, associated with an inherently limited number of source-receiver bins. We conduct a suite of inversions of both real and synthetic seismic data sets to evaluate the resolving power of our algorithm, and

  16. Quantitative approaches for profit maximization in direct marketing

    NARCIS (Netherlands)

    van der Scheer, H.R.

    1998-01-01

    An effective direct marketing campaign aims at selecting those targets, offer and communication elements - at the right time - that maximize the net profits. The list of individuals to be mailed, i.e. the targets, is considered to be the most important component. Therefore, a large amount of direct

  17. Dual Mode NOx Sensor: Measuring Both the Accumulated Amount and Instantaneous Level at Low Concentrations

    Directory of Open Access Journals (Sweden)

    Jaco H. Visser

    2012-03-01

    Full Text Available The accumulating-type (or integrating-type NOx sensor principle offers two operation modes to measure low levels of NOx: The direct signal gives the total amount dosed over a time interval and its derivative the instantaneous concentration. With a linear sensor response, no baseline drift, and both response times and recovery times in the range of the gas exchange time of the test bench (5 to 7 s, the integrating sensor is well suited to reliably detect low levels of NOx. Experimental results are presented demonstrating the sensor’s integrating properties for the total amount detection and its sensitivity to both NO and to NO2. We also show the correlation between the derivative of the sensor signal and the known gas concentration. The long-term detection of NOx in the sub-ppm range (e.g., for air quality measurements is discussed. Additionally, a self-adaption of the measurement range taking advantage of the temperature dependency of the sensitivity is addressed.

  18. 76 FR 42038 - Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit

    Science.gov (United States)

    2011-07-18

    ... investment condition''). The direct investment condition requires that the U.S. party's share of the foreign...) of this section if the foreign payment were an amount of tax paid. (3) Direct investment. The U.S... claim direct and indirect foreign tax credits. DATES: Effective Date: These regulations are effective on...

  19. Polarographic determination of trace amounts of thorium

    Energy Technology Data Exchange (ETDEWEB)

    Zaofan Zhao; Xiaohua Cai; Peibiao Li; Handong Yang

    1986-07-01

    A sensitive linear-sweep polarographic method for the determination of thorium is described. It is based on the thorium complex with Xylidyl Blue I (XBI) in a medium containing ethylenediamine, 1, 10-phenanthroline, oxalic acid and ninhydrin, at pH 10.5-11.5. The complex has been proved to be Th(XBI)/sub 2/, with log ..beta..'=9.6. The method can be used to determine trace amounts of thorium over the range 3.5x10/sup -8/-3x10/sup -6/M. The detection limit is 1x10/sup -8/M. A solvent extraction procedure is necessary to eliminate interference from several cations. The method has been applied to determination of traces of thorium in minerals, with good results.

  20. [Analysis of a Family-centred Care Programme with Follow-up Home-visits in Neonatology - In Times of the Directive from G-BA].

    Science.gov (United States)

    Hüning, B M; Reimann, M; Sahlmen, S; Leibold, S; Nabring, J C; Felderhoff-Müser, U

    2016-07-01

    Marked progress in neonatology changed care of very preterm infants (VLBW) over the last decades - but also the attitude towards family-centred care (FCC). With the directive of the German Federal Joined Committee (G-BA), politicians recognize the necessity of neonatal FCC. To evaluate time and personnel costs necessary at a centre of established FCC. Elternberatung "Frühstart" is a FCC programme for VLBW and seriously ill neonates from preganancy at risk to follow-up home-visits delivered by one interdisciplinary team. Analysis (2011-2014): 1.) Number of cases /participation in programme, 2.) resources of time, 3) and personnel, 4.) funding, 5) economic impact. 1.1.2011-31.12.2014: 441 cases (total cases: 2 212) participated in the programme. Participation of VLBW: mean 92% (86.4-97,2%). Costs of time are highest in neonates with congenital malformations: median 13.8 h, VLBW: median 11,2 h. Transition to home is most time intensive: median 7,3 (0-42.5) h. In average of 3.1 full-time nurses (part-time workers) are able to counsel 48 families/quarter. In severe cases funding is partly provided by health care insurances for social medical aftercare: positive applications: mean 92.7% (79.6-97.7%). Participation in the FCC programme in neonatology is high and costs of time are manageable. © Georg Thieme Verlag KG Stuttgart · New York.

  1. Solid-phase extraction with the metal-organic framework MIL-101(Cr) combined with direct analysis in real time mass spectrometry for the fast analysis of triazine herbicides.

    Science.gov (United States)

    Li, Xianjiang; Xing, Jiawei; Chang, Cuilan; Wang, Xin; Bai, Yu; Yan, Xiuping; Liu, Huwei

    2014-06-01

    MIL-101(Cr) is an excellent metal-organic framework with high surface area and nanoscale cavities, making it promising in solid-phase extraction. Herein, we used MIL-101(Cr) as a solid-phase extraction packing material combined with fast detection of direct analysis in real time mass spectrometry (DART-MS) for the analysis of triazine herbicides. After systematic optimization of the operation parameters, including the gas temperature of DART, the moving speed of the 1D platform, solvent for desorption, amount of MIL-101(Cr) extraction time, eluent volume and salt concentration, this method can realize the simultaneous detection of five kinds of triazine herbicides. The limits of detection were 0.1∼0.2 ng/mL and the linear ranges covered more than two orders of magnitude with the quantitation limits of 0.5∼1 ng/mL. Moreover, the developed method has been applied for the analysis of lake water samples and the recoveries for spiked analytes were in the range of 85∼110%. These results showed that solid-phase extraction with metal-organic frameworks is an efficient sample preparation approach for DART-MS analysis and could find more applications in environmental analysis. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Achieving timely percutaneous reperfusion for rural ST-elevation myocardial infarction patients by direct transport to an urban PCI-hospital.

    Science.gov (United States)

    Bennin, Charles-Lwanga K; Ibrahim, Saif; Al-Saffar, Farah; Box, Lyndon C; Strom, Joel A

    2016-10-01

    ST-elevation myocardial infarction (STEMI) guidelines recommend reperfusion by primary percutaneous coronary intervention (PCI) ≤ 90 min from time of first medical contact (FMC). This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service (EMS) STEMI field triage protocol. Sixty STEMI patients directly transported by EMS from three rural counties (Nassau, Camden and Charlton Counties) within a 50-mile radius of University of Florida Health-Jacksonville (UFHJ) from 01/01/2009 to 12/31/2013 were identified from its PCI registry. The STEMI field triage protocol incorporated three elements: (1) a cooperative agreement between each of the rural emergency medical service (EMS) agency and UFHJ; (2) performance of a pre-hospital ECG to facilitate STEMI identification and laboratory activation; and (3) direct transfer by ground transportation to the UFHJ cardiac catheterization laboratory. FMC-to-device (FMC2D), door-to-device (D2D), and transit times, the day of week, time of day, and EMS shift times were recorded, and odds ratio (OR) of achieving FMC2D times was calculated. FMC2D times were shorter for in-state STEMIs (81 ± 17 vs . 87 ± 19 min), but D2D times were similar (37 ± 18 vs . 39 ± 21 min). FMC2D ≤ 90 min were achieved in 82.7% in-state STEMIs compared to 52.2% for out-of-state STEMIs (OR = 4.4, 95% CI: 1.24-15.57; P = 0.018). FMC2D times were homogenous after adjusting for weekday vs . weekend, EMS shift times. Nine patients did not meet FMC2D ≤ 90 min. Six were within 10 min of target; all patient achieved FMC2D ≤ 120 min. Guideline-compliant FMC2D ≤ 90 min is achievable for rural STEMI patients within a 50 mile radius of a PCI-capable hospital by use of protocol-driven EMS ground

  3. Impact of time-of-flight on indirect 3D and direct 4D parametric image reconstruction in the presence of inconsistent dynamic PET data

    Science.gov (United States)

    Kotasidis, F. A.; Mehranian, A.; Zaidi, H.

    2016-05-01

    Kinetic parameter estimation in dynamic PET suffers from reduced accuracy and precision when parametric maps are estimated using kinetic modelling following image reconstruction of the dynamic data. Direct approaches to parameter estimation attempt to directly estimate the kinetic parameters from the measured dynamic data within a unified framework. Such image reconstruction methods have been shown to generate parametric maps of improved precision and accuracy in dynamic PET. However, due to the interleaving between the tomographic and kinetic modelling steps, any tomographic or kinetic modelling errors in certain regions or frames, tend to spatially or temporally propagate. This results in biased kinetic parameters and thus limits the benefits of such direct methods. Kinetic modelling errors originate from the inability to construct a common single kinetic model for the entire field-of-view, and such errors in erroneously modelled regions could spatially propagate. Adaptive models have been used within 4D image reconstruction to mitigate the problem, though they are complex and difficult to optimize. Tomographic errors in dynamic imaging on the other hand, can originate from involuntary patient motion between dynamic frames, as well as from emission/transmission mismatch. Motion correction schemes can be used, however, if residual errors exist or motion correction is not included in the study protocol, errors in the affected dynamic frames could potentially propagate either temporally, to other frames during the kinetic modelling step or spatially, during the tomographic step. In this work, we demonstrate a new strategy to minimize such error propagation in direct 4D image reconstruction, focusing on the tomographic step rather than the kinetic modelling step, by incorporating time-of-flight (TOF) within a direct 4D reconstruction framework. Using ever improving TOF resolutions (580 ps, 440 ps, 300 ps and 160 ps), we demonstrate that direct 4D TOF image

  4. A depleted ozone layer absorbs less UV-B, cooling the ozone layer, increasing the amount of UV-B observed to reach Earth, heating air by dissociating tropospheric and ground-level ozone, and heating oceans very efficiently by penetrating tens of meters into the mixed layer. UV-B is 48 times more energetic ("hotter") than IR absorbed by greenhouse gases

    Science.gov (United States)

    Ward, P. L.

    2017-12-01

    This new insight into the physics of radiation shows why changes in stratospheric ozone are observed to cause changes in global temperature. By 1970, manufactured CFC gases and ozone depletion began increasing. By 1993, increases in CFCs stopped as mandated by the Montreal Protocol. By 1995, increases in ozone depletion stopped. By 1998, increases in temperature stopped until 2014. Ozone is also depleted by halogen gases emitted from major basaltic lava flows, the largest of which, since 1783, occurred at Bardarbunga in Iceland in 2014, causing 2015 and 2016 to be the hottest years on record. Throughout Earth history, the largest basaltic lava flows were contemporaneous with periods of greatest warming and greatest levels of mass extinctions. Planck's empirical law shows that temperature of matter results from oscillation of all the bonds holding matter together. The higher the temperature, the higher the frequencies and amplitudes of oscillation. Thus, radiation from a nearby hotter body will make the absorbing body hotter than radiation from a cooler body. According to the Planck-Einstein relation, thermal energy (E) in matter and in radiation equals frequency of oscillation (ν) times the Planck constant (h), E=hν—the energy of a frictionless atomic oscillator. Since frequency is observed to be a very broad continuum extending from radio signals through visible light to gamma rays, thermal energy (E=hν) must also be a very broad continuum. Thermal flux cannot be represented properly by a single number of watts per square meter, as commonly assumed throughout the physical sciences, because all frequencies coexist and the number of watts increases with frequency. Thus, UV-B solar radiation is 48 times more energetic than IR terrestrial radiation absorbed by greenhouse gases and can make the absorbing body 48 times hotter. UV-B causes sunburn; no amount of IR can cause sunburn. Furthermore, in a basic experiment, I show that air containing more than 23 times

  5. Liquid-Metal/Water Direct Contact Heat Exchange: Flow Visualization, Flow Stability, and Heat Transfer Using Real-Time X-Ray Imaging

    International Nuclear Information System (INIS)

    Abdulla, Sherif H.; Liu Xin; Anderson, Mark H.; Bonazza, Riccardo; Corradini, Michael L.; Cho, Dae; Page, Richard

    2005-01-01

    Advanced reactor system designs are being considered with liquid-metal cooling connected to a steam power cycle. In addition, current reactor safety systems are considering auxiliary cooling schemes that assure ex-vessel debris coolability utilizing direct water injection into molten material pools to achieve core quenching and eventual coolability. The phenomenon common in both applications is direct contact heat exchange. The current study focuses on detailed measurements of liquid-metal/water direct contact heat exchange that is directly applicable to improvements in effective heat transfer in devices that are being considered for both of these purposes.In this study, a test facility was designed at the University of Wisconsin-Madison to map the operating range of liquid-metal/water direct contact heat exchange. The test section (184-cm height, 45.75-cm width, and 10-cm depth) is a rectangular slice of a larger heat exchange device. This apparatus was used not only to provide measurements of integral thermal performance (i.e., volumetric heat transfer coefficient), but also local heat transfer coefficients in a bubbly flow regime with X-ray imaging based on measured parameters such as bubble formation time, bubble rise velocity, and bubble diameters.To determine these local heat transfer coefficients, a complete methodology of the X-ray radiography for two-phase flow measurement has been developed. With this methodology, a high-energy X-ray imaging system is optimized for our heat exchange experiments. With this real-time, large-area, high-energy X-ray imaging system, the two-phase flow was quantitatively visualized. An efficient image processing strategy was developed by combining several optimal digital image-processing algorithms into a software computational tool written in MATLAB called T-XIP. Time-dependent heat transfer-related variables such as bubble volumes and velocities, were determined. Finally, an error analysis associated with these measurements

  6. Forecasting of Information Security Related Incidents: Amount of Spam Messages as a Case Study

    Science.gov (United States)

    Romanov, Anton; Okamoto, Eiji

    With the increasing demand for services provided by communication networks, quality and reliability of such services as well as confidentiality of data transfer are becoming ones of the highest concerns. At the same time, because of growing hacker's activities, quality of provided content and reliability of its continuous delivery strongly depend on integrity of data transmission and availability of communication infrastructure, thus on information security of a given IT landscape. But, the amount of resources allocated to provide information security (like security staff, technical countermeasures and etc.) must be reasonable from the economic point of view. This fact, in turn, leads to the need to employ a forecasting technique in order to make planning of IT budget and short-term planning of potential bottlenecks. In this paper we present an approach to make such a forecasting for a wide class of information security related incidents (ISRI) — unambiguously detectable ISRI. This approach is based on different auto regression models which are widely used in financial time series analysis but can not be directly applied to ISRI time series due to specifics related to information security. We investigate and address this specifics by proposing rules (special conditions) of collection and storage of ISRI time series, adherence to which improves forecasting in this subject field. We present an application of our approach to one type of unambiguously detectable ISRI — amount of spam messages which, if not mitigated properly, could create additional load on communication infrastructure and consume significant amounts of network capacity. Finally we evaluate our approach by simulation and actual measurement.

  7. Quantitative real-time monitoring of multi-elements in airborne particulates by direct introduction into an inductively coupled plasma mass spectrometer

    International Nuclear Information System (INIS)

    Suzuki, Yoshinari; Sato, Hikaru; Hiyoshi, Katsuhiro; Furuta, Naoki

    2012-01-01

    A new calibration system for real-time determination of trace elements in airborne particulates was developed. Airborne particulates were directly introduced into an inductively coupled plasma mass spectrometer, and the concentrations of 15 trace elements were determined by means of an external calibration method. External standard solutions were nebulized by an ultrasonic nebulizer (USN) coupled with a desolvation system, and the resulting aerosol was introduced into the plasma. The efficiency of sample introduction via the USN was calculated by two methods: (1) the introduction of a Cr standard solution via the USN was compared with introduction of a Cr(CO) 6 standard gas via a standard gas generator and (2) the aerosol generated by the USN was trapped on filters and then analyzed. The Cr introduction efficiencies obtained by the two methods were the same, and the introduction efficiencies of the other elements were equal to the introduction efficiency of Cr. Our results indicated that our calibration method for introduction efficiency worked well for the 15 elements (Ti, V, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Sn, Sb, Ba, Tl and Pb). The real-time data and the filter-collection data agreed well for elements with low-melting oxides (V, Co, As, Mo, Sb, Tl, and Pb). In contrast, the real-time data were smaller than the filter-collection data for elements with high-melting oxides (Ti, Cr, Mn, Ni, Cu, Zn, Sn, and Ba). This result implies that the oxides of these 8 elements were not completely fused, vaporized, atomized, and ionized in the initial radiation zone of the inductively coupled plasma. However, quantitative real-time monitoring can be realized after correction for the element recoveries which can be calculated from the ratio of real-time data/filter-collection data. - Highlights: ► APs were directly introduced into ICP-MS and real-time analysis was performed. ► The real-time data were calibrated by a multi-element standard solution from USN. ► During real-time

  8. Clinical evaluation of the Abbott RealTime MTB Assay for direct detection of Mycobacterium tuberculosis-complex from respiratory and non-respiratory samples.

    Science.gov (United States)

    Hinić, Vladimira; Feuz, Kinga; Turan, Selda; Berini, Andrea; Frei, Reno; Pfeifer, Karin; Goldenberger, Daniel

    2017-05-01

    Rapid and reliable diagnosis is crucial for correct management of tuberculosis. The Abbott RealTime MTB Assay represents a novel qualitative real-time PCR assay for direct detection of M. tuberculosis-complex (MTB) DNA from respiratory samples. The test targets two highly conserved sequences, the multi-copy insertion element IS6110 and the protein antigen B (PAB) gene of MTB, allowing even the detection of IS6610-deficient strains. We evaluated this commercial diagnostic test by analyzing 200 respiratory and, for the first time, 87 non-respiratory clinical specimens from our tertiary care institution and compared its results to our IS6110-based in-house real-time PCR for MTB as well as MTB culture. Overall sensitivity for Abbott RealTime MTB was 100% (19/19) in smear positive and 87.5% (7/8) in smear negative specimens, while the specificity of the assay was 100% (260/260). For both non-respiratory smear positive and smear negative specimens Abbott RealTime MTB tests showed 100% (8/8) sensitivity and 100% (8/8) specificity. Cycle threshold (Ct) value analysis of 16 MTB positive samples showed a slightly higher Ct value of the Abbott RealTime MTB test compared to our in-house MTB assay (mean delta Ct = 2.55). In conclusion, the performance of the new Abbott RealTime MTB Assay was highly similar to culture and in-house MTB PCR. We document successful analysis of 87 non-respiratory samples with the highly automated Abbott RealTime MTB test with no inhibition observed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Direct atmospheric pressure chemical ionization-tandem mass spectrometry for the continuous real-time trace analysis of benzene, toluene, ethylbenzene, and xylenes in ambient air.

    Science.gov (United States)

    Badjagbo, Koffi; Picard, Pierre; Moore, Serge; Sauvé, Sébastien

    2009-05-01

    Real-time monitoring of benzene, toluene, ethylbenzene, and xylenes (BTEX) in ambient air is essential for the early warning detection associated with the release of these hazardous chemicals and in estimating the potential exposure risks to humans and the environment. We have developed a tandem mass spectrometry (MS/MS) method for continuous real-time determination of ambient trace levels of BTEX. The technique is based on the sampling of air via an atmospheric pressure inlet directly into the atmospheric pressure chemical ionization (APCI) source. The method is linear over four orders of magnitude, with correlation coefficients greater than 0.996. Low limits of detection in the range 1-2 microg/m(3) are achieved for BTEX. The reliability of the method was confirmed through the evaluation of quality parameters such as repeatability and reproducibility (relative standard deviation below 8% and 10%, respectively) and accuracy (over 95%). The applicability of this method to real-world samples was evaluated through measurements of BTEX levels in real ambient air samples and results were compared with a reference GC-FID method. This direct APCI-MS/MS method is suitable for real-time analysis of BTEX in ambient air during regulation surveys as well as for the monitoring of industrial processes or emergency situations.

  10. Rapid identification of pathogens directly from blood culture bottles by Bruker matrix-assisted laser desorption laser ionization-time of flight mass spectrometry versus routine methods.

    Science.gov (United States)

    Jamal, Wafaa; Saleem, Rola; Rotimi, Vincent O

    2013-08-01

    The use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification of microorganisms directly from blood culture is an exciting dimension to the microbiologists. We evaluated the performance of Bruker SepsiTyper kit™ (STK) for direct identification of bacteria from positive blood culture. This was done in parallel with conventional methods. Nonrepetitive positive blood cultures from 160 consecutive patients were prospectively evaluated by both methods. Of 160 positive blood cultures, the STK identified 114 (75.6%) isolates and routine conventional method 150 (93%). Thirty-six isolates were misidentified or not identified by the kit. Of these, 5 had score of >2.000 and 31 had an unreliable low score of <1.7. Four of 8 yeasts were identified correctly. The average turnaround time using the STK was 35 min, including extraction steps and 30:12 to 36:12 h with routine method. The STK holds promise for timely management of bacteremic patients. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. Work-Family Conflict: Does Educational Attainment Influence the Amount of Negative Spillover?

    Science.gov (United States)

    Erarslan, Ayse Burcin

    2009-01-01

    Using a data from a purposive sample of 216 women and 218 men in Turkey, the relationship between educational attainment and the amount of negative spillover from job-to-home and home-to-job was examined. It was hypothesized that men and women with higher levels of education have less amount of negative spillover in both directions. Certain work…

  12. DEFERRED TAXES GENERATED BY THE CAPITALIZED INTERESTS IN THE AMOUNT

    Directory of Open Access Journals (Sweden)

    PALIU – POPA LUCIA

    2015-08-01

    Full Text Available According to the General Framework for preparing and presenting the financial statements elaborated by IASB, the utility of information is provided by attributes (qualitative features, such as: intelligibility, relevance, credibility and comparability. For being credible, the financial information shall be erroneous, shall not be biased or deforming the patrimony, and one of the elements representing and defining the information credibility is the prudency. Thus, the prudential accounting treatments affect, on the one hand, the accounting information relevance and credibility, and on the other hand, equally, both the producers as well as the users of the financial information, due to the economic consequences which are generated. From this perspective and considering that the implied economic agents are not neutral in terms of their option concerning the neutral accounting practices, prudent or aggressive, we opined that it is useful to conduct a study aiming the relevance of the accounting information related to the deferred taxes generated by the capitalized interests in the amount of the fix assets, recognizing the value of these taxes having as result the compliance with the principle of prudency within the accountancy. In this context, compared to the dominant accounting systems, respectively the continental system and the Anglo- Saxon system, within which the accounting information is characterized as legal, respectively addressed to the external users, especially to the investors, the conducted study aimed the following directions: the main differences between the provisions of the national, European, Anglo-Saxon accounting regulations and those of the international referential related to the prudency; the occurrence and evolution of the deferred taxes generated by the capitalized interests in the amount of the fix assets; informational benefits of the accounting prudency concerning the reflection of the deferred taxes established by the

  13. Interaction between Gender and Skill on Competitive State Anxiety Using the Time-to-Event Paradigm: What Roles Do Intensity, Direction, and Frequency Dimensions Play?

    Directory of Open Access Journals (Sweden)

    John E. Hagan

    2017-05-01

    Full Text Available Background and purpose: The functional understanding and examination of competitive anxiety responses as temporal events that unfold as time-to-competition moves closer has emerged as a topical research area within the domains of sport psychology. However, little is known from an inclusive and interaction oriented perspective. Using the multidimensional anxiety theory as a framework, the present study examined the temporal patterning of competitive anxiety, focusing on the dimensions of intensity, direction, and frequency of intrusions in athletes across gender and skill level.Methods: Elite and semi-elite table tennis athletes from the Ghanaian league (N = 90 completed a modified version of Competitive State Anxiety Inventory-2 (CSAI-2 with the inclusion of the directional and frequency of intrusion scales at three temporal phases (7 days, 2 days, and 1 h prior to a competitive fixture.Results: Multivariate Analyses of Variance repeated measures with follow-up analyses revealed significant interactions for between-subjects factors on all anxiety dimensions (intensity, direction, and frequency. Notably, elite (international female athletes were less cognitively anxious, showed more facilitative interpretation toward somatic anxiety symptoms and experienced less frequency of somatic anxiety symptoms than their male counterparts. However, both elite groups displayed appreciable level of self-confidence. For time-to-event effects, both cognitive and somatic anxiety intensity fluctuated whereas self-confidence showed a steady rise as competition neared. Somatic anxiety debilitative interpretation slightly improved 1 h before competition whereas cognitive anxiety frequencies also increased progressively during the entire preparatory phase.Conclusion: Findings suggest a more dynamic image of elite athletes’ pre-competitive anxiety responses than suggested by former studies, potentially influenced by cultural differences. The use of psychological

  14. An optimized work-flow to reduce time-to-detection of carbapenemase-producing Enterobacteriaceae (CPE) using direct testing from rectal swabs.

    Science.gov (United States)

    O'Connor, C; Kiernan, M G; Finnegan, C; O'Hara, M; Power, L; O'Connell, N H; Dunne, C P

    2017-05-04

    Rapid detection of patients with carbapenemase-producing Enterobacteriaceae (CPE) is essential for the prevention of nosocomial cross-transmission, allocation of isolation facilities and to protect patient safety. Here, we aimed to design a new laboratory work-flow, utilizing existing laboratory resources, in order to reduce time-to-diagnosis of CPE. A review of the current CPE testing processes and of the literature was performed to identify a real-time commercial polymerase chain reaction (PCR) assay that could facilitate batch testing of CPE clinical specimens, with adequate CPE gene coverage. Stool specimens (210) were collected; CPE-positive inpatients (n = 10) and anonymized community stool specimens (n = 200). Rectal swabs (eSwab™) were inoculated from collected stool specimens and a manual DNA extraction method (QIAamp® DNA Stool Mini Kit) was employed. Extracted DNA was then processed on the Check-Direct CPE® assay. The three step process of making the eSwab™, extracting DNA manually and running the Check-Direct CPE® assay, took method of CPE screening; average time-to-diagnosis of 48/72 h. Utilizing this CPE work-flow would allow a 'same-day' result. Antimicrobial susceptibility testing results, as is current practice, would remain a 'next-day' result. In conclusion, the Check-Direct CPE® assay was easily integrated into a local laboratory work-flow and could facilitate a large volume of CPE screening specimens in a single batch, making it cost-effective and convenient for daily CPE testing.

  15. An Abnormal Increase of Fatigue Life with Dwell Time during Creep-Fatigue Deformation for Directionally Solidified Ni-Based Superalloy DZ445

    Science.gov (United States)

    Ding, Biao; Ren, Weili; Deng, Kang; Li, Haitao; Liang, Yongchun

    2018-03-01

    The paper investigated the creep-fatigue behavior for directionally solidified nickel-based superalloy DZ445 at 900 °C. It is found that the fatigue life shows an abnormal increase when the dwell time exceeds a critical value during creep-fatigue deformation. The area of hysteresis loop and fractograph explain the phenomenon quite well. The shortest life corresponds to the maximal area of hysteresis loop, i. e. the maximum energy to be consumed during the creep-fatigue cycle. The fractographic observation of failed samples further supports the abnormal behavior of fatigue life.

  16. Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process.

    Science.gov (United States)

    Singh, Ravendra; Román-Ospino, Andrés D; Romañach, Rodolfo J; Ierapetritou, Marianthi; Ramachandran, Rohit

    2015-11-10

    The pharmaceutical industry is strictly regulated, where precise and accurate control of the end product quality is necessary to ensure the effectiveness of the drug products. For such control, the process and raw materials variability ideally need to be fed-forward in real time into an automatic control system so that a proactive action can be taken before it can affect the end product quality. Variations in raw material properties (e.g., particle size), feeder hopper level, amount of lubrication, milling and blending action, applied shear in different processing stages can affect the blend density significantly and thereby tablet weight, hardness and dissolution. Therefore, real time monitoring of powder bulk density variability and its incorporation into the automatic control system so that its effect can be mitigated proactively and efficiently is highly desired. However, real time monitoring of powder bulk density is still a challenging task because of different level of complexities. In this work, powder bulk density which has a significant effect on the critical quality attributes (CQA's) has been monitored in real time in a pilot-plant facility, using a NIR sensor. The sensitivity of the powder bulk density on critical process parameters (CPP's) and CQA's has been analyzed and thereby feed-forward controller has been designed. The measured signal can be used for feed-forward control so that the corrective actions on the density variations can be taken before they can influence the product quality. The coupled feed-forward/feed-back control system demonstrates improved control performance and improvements in the final product quality in the presence of process and raw material variations. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Effect of increasing amounts of straw on pigs’ explorative behaviour

    DEFF Research Database (Denmark)

    Jensen, Margit Bak; Herskin, Mette S.; Forkman, Björn

    2015-01-01

    According to European legislation, pigs must have permanent access to sufficient quantity of materialto enable manipulation activities. However, few studies have quantified how much straw is needed tofulfil the requirements of growing pigs. We investigated the effect of increasing amount of straw...... on pigs’manipulation of the straw, and hypothesised that after a certain point increasing straw amount will nolonger increase oral manipulation further. From 30 to 80 kg live weight, pigs were housed in 90 groups of18 pigs in pens (5.48 m × 2.48 m) with partly slatted concrete floor and daily provided...... with the percentage ofpigs manipulating straw simultaneously. This was recorded in three 1-h intervals (1 h before and 1 h afterstraw allocation in the morning, as well as from 17 to 18 h in the afternoon). With increasing quantity ofstraw provided, we found a curvilinear (P increase in the time spent in oral...

  18. Development of Electronic Medical Record-Based "Rounds Report" Results in Improved Resident Efficiency, More Time for Direct Patient Care and Education, and Less Resident Duty Hour Violations.

    Science.gov (United States)

    Ham, Phillip B; Anderton, Toby; Gallaher, Ryan; Hyrman, Mike; Simmerman, Erika; Ramanathan, Annamalai; Fallaw, David; Holsten, Steven; Howell, Charles Gordon

    2016-09-01

    Surgeons frequently report frustration and loss of efficiency with electronic medical record (EMR) systems. Together, surgery residents and a programmer at Augusta University created a rounds report (RR) summarizing 24 hours of vitals, intake/output, labs, and other values for each inpatient that were previously transcribed by hand. The objective of this study was to evaluate the RR's effect on surgery residents. Surgery residents were queried to assess the RR's impact. Outcome measures were time spent preparing for rounds, direct patient care time, educational activity time, rates of incorrect/incomplete data on rounds, and rate of duty hour violations. Hospital wide, 17,200 RRs were generated in the 1-month study. Twenty-three surgery residents participated. Time spent preparing for rounds decreased per floor patient (15.6 ± 3.0 vs 6.0 ± 1.2, P care unit patient (19.9 ± 2.9 vs 7.5 ± 1.2 P care increased from 45.1 ± 5.6 to 54.0 ± 5.7 per cent (P = 0.0044). Educational activity time increased from 35.2 ± 5.4 to 54.7 ± 7.1 minutes per resident per day (P = 0.0004). Reported duty hour violations decreased 58 per cent (P care at academic medical centers.

  19. Direct on-strip analysis of size- and time-resolved aerosol impactor samples using laser induced fluorescence spectra excited at 263 and 351 nm

    International Nuclear Information System (INIS)

    Wang, Chuji; Pan, Yong-Le; James, Deryck; Wetmore, Alan E.; Redding, Brandon

    2014-01-01

    Highlights: • A dual wavelength UV-LIF spectra-rotating drum impactor (RDI) technique was developed. • The technique was demonstrated by direct on-strip analysis of size- and time-resolved LIF spectra of atmospheric aerosol particles. • More than 2000 LIF spectra of atmospheric aerosol particles collected over three weeks in Djibouti were obtained and assigned to various fluorescence clusters. • The LIF spectra showed size- and time-sensitivity behavior with a time resolution of 3.6 h. - Abstract: We report a novel atmospheric aerosol characterization technique, in which dual wavelength UV laser induced fluorescence (LIF) spectrometry marries an eight-stage rotating drum impactor (RDI), namely UV-LIF-RDI, to achieve size- and time-resolved analysis of aerosol particles on-strip. The UV-LIF-RDI technique measured LIF spectra via direct laser beam illumination onto the particles that were impacted on a RDI strip with a spatial resolution of 1.2 mm, equivalent to an averaged time resolution in the aerosol sampling of 3.6 h. Excited by a 263 nm or 351 nm laser, more than 2000 LIF spectra within a 3-week aerosol collection time period were obtained from the eight individual RDI strips that collected particles in eight different sizes ranging from 0.09 to 10 μm in Djibouti. Based on the known fluorescence database from atmospheric aerosols in the US, the LIF spectra obtained from the Djibouti aerosol samples were found to be dominated by fluorescence clusters 2, 5, and 8 (peaked at 330, 370, and 475 nm) when excited at 263 nm and by fluorescence clusters 1, 2, 5, and 6 (peaked at 390 and 460 nm) when excited at 351 nm. Size- and time-dependent variations of the fluorescence spectra revealed some size and time evolution behavior of organic and biological aerosols from the atmosphere in Djibouti. Moreover, this analytical technique could locate the possible sources and chemical compositions contributing to these fluorescence clusters. Advantages, limitations, and

  20. Direct on-strip analysis of size- and time-resolved aerosol impactor samples using laser induced fluorescence spectra excited at 263 and 351 nm

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chuji [U.S. Army Research Laboratory, Adelphi, MD 20783 (United States); Mississippi State University, Starkville, MS, 39759 (United States); Pan, Yong-Le, E-mail: yongle.pan.civ@mail.mil [U.S. Army Research Laboratory, Adelphi, MD 20783 (United States); James, Deryck; Wetmore, Alan E. [U.S. Army Research Laboratory, Adelphi, MD 20783 (United States); Redding, Brandon [Yale University, New Haven, CT 06510 (United States)

    2014-04-01

    Highlights: • A dual wavelength UV-LIF spectra-rotating drum impactor (RDI) technique was developed. • The technique was demonstrated by direct on-strip analysis of size- and time-resolved LIF spectra of atmospheric aerosol particles. • More than 2000 LIF spectra of atmospheric aerosol particles collected over three weeks in Djibouti were obtained and assigned to various fluorescence clusters. • The LIF spectra showed size- and time-sensitivity behavior with a time resolution of 3.6 h. - Abstract: We report a novel atmospheric aerosol characterization technique, in which dual wavelength UV laser induced fluorescence (LIF) spectrometry marries an eight-stage rotating drum impactor (RDI), namely UV-LIF-RDI, to achieve size- and time-resolved analysis of aerosol particles on-strip. The UV-LIF-RDI technique measured LIF spectra via direct laser beam illumination onto the particles that were impacted on a RDI strip with a spatial resolution of 1.2 mm, equivalent to an averaged time resolution in the aerosol sampling of 3.6 h. Excited by a 263 nm or 351 nm laser, more than 2000 LIF spectra within a 3-week aerosol collection time period were obtained from the eight individual RDI strips that collected particles in eight different sizes ranging from 0.09 to 10 μm in Djibouti. Based on the known fluorescence database from atmospheric aerosols in the US, the LIF spectra obtained from the Djibouti aerosol samples were found to be dominated by fluorescence clusters 2, 5, and 8 (peaked at 330, 370, and 475 nm) when excited at 263 nm and by fluorescence clusters 1, 2, 5, and 6 (peaked at 390 and 460 nm) when excited at 351 nm. Size- and time-dependent variations of the fluorescence spectra revealed some size and time evolution behavior of organic and biological aerosols from the atmosphere in Djibouti. Moreover, this analytical technique could locate the possible sources and chemical compositions contributing to these fluorescence clusters. Advantages, limitations, and

  1. Detection of caffeine in tea, instant coffee, green tea beverage, and soft drink by direct analysis in real time (DART) source coupled to single-quadrupole mass spectrometry.

    Science.gov (United States)

    Wang, Lei; Zhao, Pengyue; Zhang, Fengzu; Bai, Aijuan; Pan, Canping

    2013-01-01

    Ambient ionization direct analysis in real time (DART) coupled to single-quadrupole MS (DART-MS) was evaluated for rapid detection of caffeine in commercial samples without chromatographic separation or sample preparation. Four commercial samples were examined: tea, instant coffee, green tea beverage, and soft drink. The response-related parameters were optimized for the DART temperature and MS fragmentor. Under optimal conditions, the molecular ion (M+H)+ was the major ion for identification of caffeine. The results showed that DART-MS is a promising tool for the quick analysis of important marker molecules in commercial samples. Furthermore, this system has demonstrated significant potential for high sample throughput and real-time analysis.

  2. "Soft"or "hard" ionisation? Investigation of metastable gas temperature effect on direct analysis in real-time analysis of Voriconazole.

    Science.gov (United States)

    Lapthorn, Cris; Pullen, Frank

    2009-01-01

    The performance of the direct analysis in real-time (DART) technique was evaluated across a range of metastable gas temperatures for a pharmaceutical compound, Voriconazole, in order to investigate the effect of metastable gas temperature on molecular ion intensity and fragmentation. The DART source has been used to analyse a range of analytes and from a range of matrices including drugs in solid tablet form and preparations, active ingredients in ointment, naturally occurring plant alkaloids, flavours and fragrances, from thin layer chromatography (TLC) plates, melting point tubes and biological matrices including hair, urine and blood. The advantages of this technique include rapid analysis time (as little as 5 s), a reduction in sample preparation requirements, elimination of mobile phase requirement and analysis of samples not typically amenable to atmospheric pressure ionisation (API) techniques. This technology has therefore been proposed as an everyday tool for identification of components in crude organic reaction mixtures.

  3. An Integrated Hot-Stage Microscope-Direct Analysis in Real Time-Mass Spectrometry System for Studying the Thermal Behavior of Materials.

    Science.gov (United States)

    Ashton, Gage P; Harding, Lindsay P; Parkes, Gareth M B

    2017-12-19

    This paper describes a new analytical instrument that combines a precisely temperature-controlled hot-stage with digital microscopy and Direct Analysis in Real Time-mass spectrometry (DART-MS) detection. The novelty of the instrument lies in its ability to monitor processes as a function of temperature through the simultaneous recording of images, quantitative color changes, and mass spectra. The capability of the instrument was demonstrated through successful application to four very varied systems including profiling an organic reaction, decomposition of silicone polymers, and the desorption of rhodamine B from an alumina surface. The multidimensional, real-time analytical data provided by this instrument allow for a much greater insight into thermal processes than could be achieved previously.

  4. Detection of polydimethylsiloxanes transferred from silicone-coated parchment paper to baked goods using direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Jakob, Andreas; Crawford, Elizabeth A; Gross, Jürgen H

    2016-04-01

    The non-stick properties of parchment papers are achieved by polydimethylsiloxane (PDMS) coatings. During baking, PDMS can thus be extracted from the silicone-coated parchment into the baked goods. Positive-ion direct analysis in real time (DART) mass spectrometry (MS) is highly efficient for the analysis of PDMS. A DART-SVP source was coupled to a quadrupole-time-of-flight mass spectrometer to detect PDMS on the contact surface of baked goods after use of silicone-coated parchment papers. DART spectra from the bottom surface of baked cookies and pizzas exhibited signals because of PDMS ions of the general formula [(C2H6SiO)n  + NH4 ](+) in the m/z 800-1900 range. Copyright © 2016 John Wiley & Sons, Ltd.

  5. The incorporation of fault zone head wave and direct wave secondary arrival times and arrival polarizations into seismic tomography: Application to the Parkfield, California area

    Science.gov (United States)

    Bennington, N. L.; Thurber, C. H.; Peng, Z.; Zhao, P.

    2012-12-01

    We present a 3D P-wave velocity (Vp) model of the Parkfield region that utilizes existing P-wave arrival time data, including fault zone head waves (FZHW), plus new data from direct wave secondary arrivals (DWSA). The first-arrival and DWSA travel times are obtained as the global and local minimum travel time paths, respectively. The inclusion of DWSA results in as much as a 10% increase in the across-fault velocity contrast for the Vp model at Parkfield relative to Thurber et al. (2006). Viewed along strike, three pronounced velocity contrast regions are observed: a pair of strong positive velocity contrasts (SW fast), one NW of the 1966 Parkfield hypocenter and the other SE of the 2004 Parkfield hypocenter, and a strong negative velocity contrast (NE fast) between the two hypocenters. The negative velocity contrast partially to entirely encompasses peak coseismic slip estimated in several slip models for the 2004 earthquake, suggesting that the negative velocity contrast played a part in defining the rupture patch of the 2004 Parkfield earthquake. We expand on this work by modifying our seismic tomography algorithm to incorporate arrival polarizations (azimuths). Synthetic tests will be presented to demonstrate the improvements in velocity structure when arrival polarizations are incorporated. These tests will compare the synthetic model recovered when FZHW/DWSA arrivals as well as existing P-wave arrival time data are inverted to that recovered with the same dataset with the inclusion of arrival polarizations. We plan to extend this work to carry out a full scale seismic tomography/relocation inversion at Parkfield, CA utilizing arrival polarizations from all first-P arrivals, and FZHW/DWSA arrivals as well as existing P-wave arrival time data. This effort requires the determination of polarization data for all P-waves and FZHW's at Parkfield. To this end, we use changes in the arrival azimuth from fault normal to source-receiver direction to identify FZHW and

  6. Direct duplex real-time loop mediated isothermal amplification assay for the simultaneous detection of cow and goat species origin of milk and yogurt products for field use.

    Science.gov (United States)

    Kim, Mi-Ju; Kim, Hae-Yeong

    2018-04-25

    A multiple loop-mediated isothermal amplification (LAMP) method was developed to detect cow and goat milk in the field using a portable fluorescence device. For rapid on-site detection, this duplex LAMP assay was used in combination with direct amplification, without DNA extraction. The cow- and goat-specific LAMP primer sets were designed based on the mitochondrial cytochrome b gene, and showed specificity against 13 other animal species in the reactions. The sensitivity of the duplex LAMP assay for cow and goat was 0.1 and 1 pg, respectively. The detection limit for both target species in milk mixtures was 2%. This assay successfully amplified and identified the two target species in 24 samples of commercial milk and yogurt products, with 30 min sampling-to-result analysis time. Therefore, this direct duplex real-time LAMP assay is useful for on-site simultaneous detection of cow and goat milk in commercial products, a capability needed to confirm accurate labeling. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Bolus injections of measured amounts of radioactivity

    International Nuclear Information System (INIS)

    Wesolowski, C.A.; Hogendoorn, P.; Vandierendonck, R.; Driedger, A.A.

    1988-01-01

    Many time-based radionuclide techniques, such as glomerular filtration rate measurement (GFR), require prompt intravenous delivery of and accurately measured tracer bolus with minimal residual tracer retention at the injection site. The quality assurance aspects of two antecubital vein, quantitative injection techniques were investigated. A flush bolus technique using a tuberculin syringe piggybacked onto a 10-ml saline flush was compared to a single blood pressure cuff injection technique. Scintillation camera data for each technique were compared for bolus duration in the abdominal aorta and for residual activity at the injection site at 5 min. Bolus times were measured as the FWHM of the gamma variate fit to the abdominal aortic regional time-activity curves. Relatively little focal activity was seen in the antecubital injection site following the flush bolus: marked residual activity was seen following the blood pressure cuff injections. The injection site/arm background ratios averaged 1.3 for the flush bolus and 30.1 for the cuff technique. Although both methods allowed accurate in vitro determination of administered radioactivity, only the tuberculin syringe flush bolus technique was acceptable for time-based quantitation because of its superior in vivo characteristics

  8. 76 FR 59138 - Medicare Program; Medicare Appeals; Adjustment to the Amount in Controversy Threshold Amounts for...

    Science.gov (United States)

    2011-09-23

    ... Administrative Law Judge (ALJ) hearings and judicial review under the Medicare appeals process. The adjustment to the AIC threshold amounts will be effective for requests for ALJ hearings and judicial review filed on... $1,350 for judicial review. DATES: Effective Date: This notice is effective on January 1, 2012. FOR...

  9. 75 FR 58407 - Medicare Program; Medicare Appeals; Adjustment to the Amount in Controversy Threshold Amounts for...

    Science.gov (United States)

    2010-09-24

    ... Administrative Law Judge (ALJ) hearings and judicial review under the Medicare appeals process. The adjustment to the AIC threshold amounts will be effective for requests for ALJ hearings and judicial review filed on... judicial review. DATES: Effective Date: This notice is effective on January 1, 2011. FOR FURTHER...

  10. 78 FR 59702 - Medicare Program; Medicare Appeals: Adjustment to the Amount in Controversy Threshold Amounts for...

    Science.gov (United States)

    2013-09-27

    ... Administrative Law Judge (ALJ) hearings and judicial review under the Medicare appeals process. The adjustment to the AIC threshold amounts will be effective for requests for ALJ hearings and judicial review filed on... ALJ hearings and $1,430 for judicial review. DATES: This notice is effective on January 1, 2014. FOR...

  11. 77 FR 59618 - Medicare Program; Medicare Appeals; Adjustment to the Amount in Controversy Threshold Amounts for...

    Science.gov (United States)

    2012-09-28

    ... Administrative Law Judge (ALJ) hearings and judicial review under the Medicare appeals process. The adjustment to the AIC threshold amounts will be effective for requests for ALJ hearings and judicial review filed on... $1,400 for judicial review. Effective Date: This notice is effective on January 1, 2013. FOR FURTHER...

  12. Less work: more burnout? A comparison of working conditions and the risk of burnout by German physicians before and after the implementation of the EU Working Time Directive.

    Science.gov (United States)

    Richter, Astrid; Kostova, Petya; Baur, Xaver; Wegner, Ralf

    2014-02-01

    The present study is a 10-year comparison (1997 vs. 2007) of occupational and health aspects before and after the implementation of the European Working Time Directive on German hospital physicians. A major focus is whether the changes in working conditions are accompanied by a lower risk for burnout. Three hundred and twenty-eight physicians from the Medical Register of the city of Hamburg completed the survey in 1997 and 994 physicians in 2007. The response rates were 55.4 and 46.5 %, respectively. All participants filled in a 22-item version of the German translation of the Maslach Burnout Inventory. Results of multivariate covariance analyses are reported. The work of physicians has changed significantly within the 10-year period, for example, work time decreased by 4.5 h on average to 55.8 h per week in 2007. Junior physicians profited more from this development, but on-call duties increased for senior physicians in particular. The reduced hours were at the expense of fewer rests. Junior, as well as senior, physicians reported significantly higher rates on the burnout scale for emotional exhaustion (mean 21.8, SD 10.7) in the latter survey and senior physicians also on the depersonalization scale (mean 9.7, SD 6.3). Changes in working conditions in accordance with the European Working Time Directive are not accompanied by reduced strain and risk of burnout for physicians. Rather, our data argue for greater intensification in work, especially for senior physicians. Further studies are suggested in order to explore interventions for a sustainable improvement in the working conditions of physicians.

  13. SOUFFLE WITH REDUCED AMOUNT OF SUGAR

    Directory of Open Access Journals (Sweden)

    G. O. Magomedov

    2014-01-01

    Full Text Available Summary. Was studied the technology of producing aerated candies "Souffle" with replacement of sugar to molasses with increased shelf life, molded by "jetting" with a vacuum syringe with continuous action, which is used in the meat industry, into metallized film type "flow-pack ". Studied the process of foaming disperse systems. Studied the process of gelation and gelation affected by various factors. To establish a relationship between the effective viscosity and jelly mass of gelation ability of agar were achieved the dependence according to the effective viscosity of the jelly mass shear rate and a shear rate on the shear stress at temperature of 65 ˚C and a mass fraction of solids of 78%. Viscosity reduction has a positive effect on the process of molding molasses candies by the "extrusion". Were definede values of the plastic strength of jelly masses and found that replacing sugar to molasses reduces the plastic strength, but it does not affect a good form-stable ability. Cinnamon was added into the prescription whipped composition to improve the nutritional value of products. Were defined organoleptic, physical and chemical qualities, calculated energy value of the products. High hygroscopic souffle on molasses requires hermetic packaging. Proposed a new progressive method of forming a souffle with a vacuum syringe with continuous action, which is used in the meat industry to form sausages. Curing and structure foarming implemented directly in the shell for 2 h, which is an important advantage of this method. Whipped products on molasses are functional.

  14. A fast direct method for block triangular Toeplitz-like with tri-diagonal block systems from time-fractional partial differential equations

    Science.gov (United States)

    Ke, Rihuan; Ng, Michael K.; Sun, Hai-Wei

    2015-12-01

    In this paper, we study the block lower triangular Toeplitz-like with tri-diagonal blocks system which arises from the time-fractional partial differential equation. Existing fast numerical solver (e.g., fast approximate inversion method) cannot handle such linear system as the main diagonal blocks are different. The main contribution of this paper is to propose a fast direct method for solving this linear system, and to illustrate that the proposed method is much faster than the classical block forward substitution method for solving this linear system. Our idea is based on the divide-and-conquer strategy and together with the fast Fourier transforms for calculating Toeplitz matrix-vector multiplication. The complexity needs O (MNlog2 ⁡ M) arithmetic operations, where M is the number of blocks (the number of time steps) in the system and N is the size (number of spatial grid points) of each block. Numerical examples from the finite difference discretization of time-fractional partial differential equations are also given to demonstrate the efficiency of the proposed method.

  15. Determination of micro amounts of praseodymium by analogue derivative spectrophotometry

    International Nuclear Information System (INIS)

    Ishii, Hajime; Satoh, Katsuhiko.

    1986-01-01

    Derivative spectrophotometry using the analogue differentiation circuit was applied to the determination of praseodymium at the ppm level. By the proposed method, in which the second or fourth derivative spectrum of the characteristic absorption band of praseodymium(III) at 444 nm is measured, as little as 3 ppm of praseodymium can be determined directly and easily even in the presence of large amounts of other rare earths without any prior separation. Interferences from neodymium, samarium, dysprosium, holmium and erbium ions which have characteristic absorption bands around 444 nm can easily be removed by utilizing the isosbestic point in the derivative spectra of praseodymium(III) and the interfering rare earth(III). (author)

  16. Transient Stability Assessment of Power System with Large Amount of Wind Power Penetration

    DEFF Research Database (Denmark)

    Liu, Leo; Chen, Zhe; Bak, Claus Leth

    2012-01-01

    Recently, the security and stability of power system with large amount of wind power are the concerned issues, especially the transient stability. In Denmark, the onshore and offshore wind farms are connected to distribution system and transmission system respectively. The control and protection...... methodologies of onshore and offshore wind farms definitely affect the transient stability of power system. In this paper, the onshore and offshore wind farms are modeled in detail in order to assess the transient stability of western Danish power system. Further, the computation of critical clearing time (CCT...... plants, load consumption level and high voltage direct current (HVDC) transmission links are taken into account. The results presented in this paper are able to provide an early awareness of power system security condition of the western Danish power system....

  17. Limits to preference and the sensitivity of choice to rate and amount of food.

    Science.gov (United States)

    Aparicio, Carlos F; Baum, William M; Hughes, Christine E; Pitts, Raymond C

    2016-03-01

    Studies of choice holding food-amount ratio constant while varying food-rate ratio within sessions showed that local changes in preference depend on relative amount of food. The present study investigated whether sensitivity of choice to food-rate ratio and sensitivity to food-amount ratio are independent of one another when food-rate ratios are varied across sessions and food-amount ratios are varied within sessions. Food deliveries for rats' presses on the left and right levers were scheduled according to three different food-rate ratios of 1:1, 9:1, and 1:9; each food-rate ratio lasted for 106 sessions and was arranged independently of seven food-amount ratios (7:1, 6:2, 5:3, 4:4, 3:5, 2:6, and 1:7 food pellets) occurring within sessions in random sequence. Each amount ratio lasted for 10 food deliveries and was separated from another by a 60-s blackout. Sensitivity to rate ratio was high (1.0) across food deliveries. Sensitivity to amount ratio was low when food rates were equal across alternatives, but was high when rate ratio and amount ratio opposed one another. When rate ratio and amount ratio went in the same direction, choice ratio reached an elevenfold limit which reduced sensitivity to approximately zero. We conclude that three factors affect sensitivity to amount: (1) the limit to preference, (2) the equal effect on preference of amounts greater than four pellets, and (3) the absence of differential effects of switches in amount in the equal-rates (1:1) condition. Taken together, these findings indicate that rate and amount only sometimes combine independently as additive variables to determine preference when amount ratios vary frequently within sessions. © 2016 Society for the Experimental Analysis of Behavior.

  18. Rapid fingerprinting of sterols and related compounds in vegetable and animal oils and phytosterol enriched- margarines by transmission mode direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Alberici, Rosana M; Fernandes, Gabriel D; Porcari, Andréia M; Eberlin, Marcos N; Barrera-Arellano, Daniel; Fernández, Facundo M

    2016-11-15

    Plant-derived sterols, often referred to as phytosterols, are important constituents of plant membranes where they assist in maintaining phospholipid bilayer stability. Consumption of phytosterols has been suggested to positively affect human health by reducing cholesterol levels in blood via inhibition of its absorption in the small intestine, thus protecting against heart attack and stroke. Sterols are challenging analytes for mass spectrometry, since their low polarity makes them difficult to ionize by both electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), typically requiring derivatization steps to overcome their low ionization efficiencies. We present a fast and reliable method to characterize the composition of phytosterols in vegetable oils and enriched margarines. The method requires no derivatization steps or sample extraction procedures thanks to the use of transmission mode direct analysis in real time mass spectrometry (TM-DART-MS). Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. [Rapid screening the alkaloids of poppy shell in hot pot condiment, beef noodle soup and seasoning by direct analysis in real time-tandem mass spectrometry].

    Science.gov (United States)

    Zhang, Baile; Gao, Lihong; Xie, Yingshuang; Zhou, Wei; Chen, Xiaofeng; Lei, Chunni; Zhang, Huan

    2017-07-08

    A direct analysis in real time tandem mass spectrometry (DART-MS/MS) method was established for quickly screening five illegally added alkaloids of poppy shell from the hot pot condiment, beef noodle soup and seasoning. The samples were extracted and purified by acetonitrile, and then injected under the conditions of ionization temperature of 300℃, grid electrode voltage of 150 V and sampling rate of 0.8 mm/s using DART in the positive ion mode. The determination was conducted by tandem mass spectrometry in positive ESI mode under multiple reaction monitoring (MRM) mode. The method is simple and rapid, and can meet the requirement of rapid screening and analysis of large quantities of samples.

  20. Rapid screening and distribution of bioactive compounds in different parts of Berberis petiolaris using direct analysis in real time mass spectrometry

    Directory of Open Access Journals (Sweden)

    Awantika Singh

    2015-10-01

    Full Text Available Berberis petiolaris Wall. ex G. Don, an unexplored medicinal plant belonging to the family Berberidaceae, is a large deciduous shrub found in Western Himalaya between 1800–3000 m. Chemical profiling of fruit, leaf, root and stem was done by direct analysis in real time mass spectrometry followed by multivariate analysis for discrimination among the plant parts. The bioactive compounds, including magnoflorine, berberine, jatrorrhizine, thalifendine/berberrubine, demethyleneberberine, reticuline, 8-oxoberberine, N-methyltetrahydroberberine, tetrahydropalmatine, tetrahydroberberine and palmatine, were identified by their exact mass measurement and the corresponding molecular formula of each compound. A comparative study of distribution pattern for all these bioactive alkaloids showed qualitative and quantitative variations in different parts of B. petiolaris. Principal component analysis clearly discriminated each part of B. petiolaris plant. Keywords: Berberis petiolaris, Alkaloids, Profiling, DART–TOF–MS, Statistical analysis

  1. THE ORIGINS OF THE CASHLESS SOCIETY: CASH DISPENSERS, DIRECT TO ACCOUNT PAYMENTS AND THE DEVELOPMENT OF ON-LINE REAL-TIME NETWORKS, C.1965-1985

    Directory of Open Access Journals (Sweden)

    Bernardo Bátiz-Lazo

    2014-07-01

    Full Text Available This article explores the technological choices made at the dawn of the massification of retail finance. We describe and analyze the early development of electronic banking and the foundations of the cashless society through the experiences of organizations with similar governance in two different competitive environments — Swedish and British savings banks. We document how the adoption of direct-to-account wage deposits and the subsequent deployment of networks of cash dispensers interacted with the adoption of on-line real-time (OLRT computing, and distinguish on- line and OLRT communication as distinct stages in the evolution of computer networks. We emphasize the role of middle managers in the selection of alternative technologies and show how delivering a cashless society proved more difficult than anticipated.

  2. 24 CFR 891.525 - Amount and terms of financing.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Amount and terms of financing. 891... Handicapped-Section 8 Assistance § 891.525 Amount and terms of financing. (a) The amount of financing approved... financing provided shall not exceed the lesser of: (1) The dollar amounts stated in paragraphs (b) through...

  3. 45 CFR 149.100 - Amount of reimbursement.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Amount of reimbursement. 149.100 Section 149.100... REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reinsurance Amounts § 149.100 Amount of reimbursement... reimbursement in the amount of 80 percent of the costs for health benefits (net of negotiated price concessions...

  4. Design and performance testing of a DNA extraction assay for sensitive and reliable quantification of acetic acid bacteria directly in red wine using real time PCR

    Directory of Open Access Journals (Sweden)

    Cédric eLONGIN

    2016-06-01

    Full Text Available Although strategies exist to prevent AAB contamination, the increased interest for wines with low sulfite addition leads to greater AAB spoilage. Hence there is a real need for a rapid, specific, sensitive and reliable method for detecting these spoilage bacteria. All these requirements are met by real time Polymerase Chain Reaction (or quantitative PCR; qPCR. Here, we compare existing methods of isolating DNA and their adaptation to a red wine matrix. Two different protocols for isolating DNA and three PCR mix compositions were tested to select the best method. The addition of insoluble polyvinylpolypyrrolidone (PVPP at 1% (v/v during DNA extraction using a protocol succeeded in eliminating PCR inhibitors from red wine. We developed a bacterial internal control which was efficient in avoiding false negative results due to decreases in the efficiency of DNA isolation and/or amplification. The specificity, linearity, repeatability and reproducibility of the method were evaluated. A standard curve was established for the enumeration of AAB inoculated into red wines. The limit of quantification in red wine was 3.7 log AAB/mL and about 2.8 log AAB/mL when the volume of the samples was increased from 1 mL to 10 mL. Thus the DNA extraction method developed in this paper allows sensitive and reliable AAB quantification without underestimation thanks to the presence of an internal control. Moreover, monitoring of both the AAB population and the amount of acetic acid in ethanol medium and red wine highlighted that a minimum about 6.0 log cells/mL of AAB is needed to significantly increase the production of acetic acid leading to spoilage.

  5. State-to-state time-of-flight measurements of NO scattering from Au(111): direct observation of translation-to-vibration coupling in electronically nonadiabatic energy transfer.

    Science.gov (United States)

    Golibrzuch, Kai; Shirhatti, Pranav R; Altschäffel, Jan; Rahinov, Igor; Auerbach, Daniel J; Wodtke, Alec M; Bartels, Christof

    2013-09-12

    Translational motion is believed to be a spectator degree of freedom in electronically nonadiabatic vibrational energy transfer between molecules and metal surfaces, but the experimental evidence available to support this view is limited. In this work, we have experimentally determined the translational inelasticity in collisions of NO molecules with a single-crystal Au(111) surface-a system with strong electronic nonadiabaticity. State-to-state molecular beam surface scattering was combined with an IR-UV double resonance scheme to obtain high-resolution time-of-flight data. The measurements include vibrationally elastic collisions (v = 3→3, 2→2) as well as collisions where one or two quanta of molecular vibration are excited (2→3, 2→4) or de-excited (2→1, 3→2, 3→1). In addition, we have carried out comprehensive measurements of the effects of rotational excitation on the translational energy of the scattered molecules. We find that under all conditions of this work, the NO molecules lose a large fraction (∼0.45) of their incidence translational energy to the surface. Those molecules that undergo vibrational excitation (relaxation) during the collision recoil slightly slower (faster) than vibrationally elastically scattered molecules. The amount of translational energy change depends on the surface temperature. The translation-to-rotation coupling, which is well-known for v = 0→0 collisions, is found to be significantly weaker for vibrationally inelastic than elastic channels. Our results clearly show that the spectator view of the translational motion in electronically nonadiabatic vibrational energy transfer between NO and Au(111) is only approximately correct.

  6. Direct comparison of {sup 210}Po, {sup 234}Th and POC particle-size distributions and export fluxes at the Bermuda Atlantic Time-series Study (BATS) site

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Gillian, E-mail: gstewart@qc.cuny.ed [Queens College, CUNY Flushing, NY 11367 (United States); Moran, S. Bradley, E-mail: moran@gso.uri.ed [Graduate School of Oceanography, URI Narragansett, RI 02882 (United States); Lomas, Michael W., E-mail: Michael.Lomas@bios.ed [Bermuda Institute for Ocean Sciences, St. George' s, GE01 (Bermuda); Kelly, Roger P., E-mail: rokelly@gso.uri.ed [Graduate School of Oceanography, URI Narragansett, RI 02882 (United States)

    2011-05-15

    Particle-reactive, naturally occurring radionuclides are useful tracers of the sinking flux of organic matter from the surface to the deep ocean. Since the Joint Global Ocean Flux Study (JGOFS) began in 1987, the disequilibrium between {sup 234}Th and its parent {sup 238}U has become widely used as a technique to measure particle export fluxes from surface ocean waters. Another radionuclide pair, {sup 210}Po and {sup 210}Pb, can be used for the same purpose but has not been as widely adopted due to difficulty with accurately constraining the {sup 210}Po/{sup 210}Pb radiochemical balance in the ocean and because of the more time-consuming radiochemical procedures. Direct comparison of particle flux estimated in different ocean regions using these short-lived radionuclides is important in evaluating their utility and accuracy as tracers of particle flux. In this paper, we present paired {sup 234}Th/{sup 238}U and {sup 210}Po/{sup 210}Pb data from oligotrophic surface waters of the subtropical Northwest Atlantic and discuss their advantages and limitations. Vertical profiles of total and particle size-fractionated {sup 210}Po and {sup 234}Th activities, together with particulate organic carbon (POC) concentrations, were measured during three seasons at the Bermuda Atlantic Time-series Study (BATS) site. Both {sup 210}Po and {sup 234}Th reasonably predict sinking POC flux caught in sediment traps, and each tracer provides unique information about the magnitude and efficiency of the ocean's biological pump.

  7. Discrimination of Bacillus anthracis Spores by Direct in-situ Analysis of Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry

    International Nuclear Information System (INIS)

    Jeong, Youngsu; Lee, Jonghee; Kim, Seongsoo

    2013-01-01

    The rapid and accurate identification of biological agents is a critical step in the case of bio-terror and biological warfare attacks. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been widely used for the identification of microorganisms. In this study, we describe a method for the rapid and accurate discrimination of Bacillus anthracis spores using MALDI-TOF MS. Our direct in-situ analysis of MALDI-TOF MS does not involve subsequent high-resolution mass analyses and sample preparation steps. This method allowed the detection of species-specific biomarkers from each Bacillus spores. Especially, B. anthracis spores had specific biomarker peaks at 2503, 3089, 3376, 6684, 6698, 6753, and 6840 m/z. Cluster and PCA analyses of the mass spectra of Bacillus spores revealed distinctively separated clusters and within-groups similarity. Therefore, we believe that this method is effective in the real-time identification of biological warfare agents such as B. anthracis as well as other microorganisms in the field

  8. A novel multivariate approach using science-based calibration for direct coating thickness determination in real-time NIR process monitoring.

    Science.gov (United States)

    Möltgen, C-V; Herdling, T; Reich, G

    2013-11-01

    This study demonstrates an approach, using science-based calibration (SBC), for direct coating thickness determination on heart-shaped tablets in real-time. Near-Infrared (NIR) spectra were collected during four full industrial pan coating operations. The tablets were coated with a thin hydroxypropyl methylcellulose (HPMC) film up to a film thickness of 28 μm. The application of SBC permits the calibration of the NIR spectral data without using costly determined reference values. This is due to the fact that SBC combines classical methods to estimate the coating signal and statistical methods for the noise estimation. The approach enabled the use of NIR for the measurement of the film thickness increase from around 8 to 28 μm of four independent batches in real-time. The developed model provided a spectroscopic limit of detection for the coating thickness of 0.64 ± 0.03 μm root-mean square (RMS). In the commonly used statistical methods for calibration, such as Partial Least Squares (PLS), sufficiently varying reference values are needed for calibration. For thin non-functional coatings this is a challenge because the quality of the model depends on the accuracy of the selected calibration standards. The obvious and simple approach of SBC eliminates many of the problems associated with the conventional statistical methods and offers an alternative for multivariate calibration. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Microneedle pH Sensor: Direct, Label-Free, Real-Time Detection of Cerebrospinal Fluid and Bladder pH.

    Science.gov (United States)

    Mani, Ganesh Kumar; Miyakoda, Kousei; Saito, Asuka; Yasoda, Yutaka; Kajiwara, Kagemasa; Kimura, Minoru; Tsuchiya, Kazuyoshi

    2017-07-05

    Acid-base homeostasis (body pH) inside the body is precisely controlled by the kidneys and lungs and buffer systems, such that even a minor pH change could severely affect many organs. Blood and urine pH tests are common in day-to-day clinical trials and require little effort for diagnosis. There is always a great demand for in vivo testing to understand more about body metabolism and to provide effective diagnosis and therapy. In this article, we report the simple fabrication of microneedle-based direct, label-free, and real-time pH sensors. The reference and working electrodes were Ag/AgCl thick films and ZnO thin films on tungsten (W) microneedles, respectively. The morphological and structural characteristics of microneedles were carefully investigated through various analytical methods. The developed sensor exhibited a Nernstian response of -46 mV/pH. Different conditions were used to test the sensor to confirm their accuracy and stability, such as various buffer solutions, with respect to time, and we compared the reading with commercial pH electrodes. Besides that, the fabricated microneedle sensor ability is proven by in vivo testing in mouse cerebrospinal fluid (CSF) and bladders. The pH sensor procedure reported here is totally reversible, and results were reproducible after several rounds of testing.

  10. Direct identification from positive blood broth culture by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS).

    Science.gov (United States)

    Barberino, Maria Goreth; Silva, Marcio de Oliveira; Arraes, Ana Carolina Palmeiras; Correia, Luís Cláudio; Mendes, Ana Verena

    Bloodstream infections (BSIs) are among the most concerning bacterial infections. They are one of the leading causes of morbidity and mortality, and occur in 30-70% of critical care patients. The prompt identification of the causative microorganism can help choosing the appropriate antimicrobial therapy that will lead to better clinical outcomes. Blood culture is one of the most relevant tests for microbiological diagnosis of bacterial infections. The introduction of the MALDI-TOF microbiological diagnosis significantly decreased the time of identifying microorganisms. However, it depends on the growth on solid culture medium. In this study, 538 bottles of positive blood cultures were evaluated to test the accuracy of an in house modified protocol. The study sample consisted of 198 Gram-negative and 350 Gram-positive bacteria. In all, 460 (83.94%) species were identified based on the direct plate findings. The protocol allowed the identification of 185/198 (93.43%) of the Gram-negative bacteria, including aerobes, anaerobes, and non-fermenters, and 275/350 (78.85%) of the Gram-positive bacteria. The proposed method has the potential to provide accurate results in comparison to the traditional method with the potential to reduce the turnaround time for the results and optimize antimicrobial therapy in BSI. Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  11. Direct identification from positive blood broth culture by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS

    Directory of Open Access Journals (Sweden)

    Maria Goreth Barberino

    2017-05-01

    Full Text Available Bloodstream infections (BSIs are among the most concerning bacterial infections. They are one of the leading causes of morbidity and mortality, and occur in 30–70% of critical care patients. The prompt identification of the causative microorganism can help choosing the appropriate antimicrobial therapy that will lead to better clinical outcomes. Blood culture is one of the most relevant tests for microbiological diagnosis of bacterial infections. The introduction of the MALDI-TOF microbiological diagnosis significantly decreased the time of identifying microorganisms. However, it depends on the growth on solid culture medium. In this study, 538 bottles of positive blood cultures were evaluated to test the accuracy of an in house modified protocol. The study sample consisted of 198 Gram-negative and 350 Gram-positive bacteria. In all, 460 (83.94% species were identified based on the direct plate findings. The protocol allowed the identification of 185/198 (93.43% of the Gram-negative bacteria, including aerobes, anaerobes, and non-fermenters, and 275/350 (78.85% of the Gram-positive bacteria. The proposed method has the potential to provide accurate results in comparison to the traditional method with the potential to reduce the turnaround time for the results and optimize antimicrobial therapy in BSI.

  12. Discrimination of Bacillus anthracis Spores by Direct in-situ Analysis of Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Youngsu; Lee, Jonghee; Kim, Seongsoo [Agency for Defense Development, Daejeon (Korea, Republic of)

    2013-09-15

    The rapid and accurate identification of biological agents is a critical step in the case of bio-terror and biological warfare attacks. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been widely used for the identification of microorganisms. In this study, we describe a method for the rapid and accurate discrimination of Bacillus anthracis spores using MALDI-TOF MS. Our direct in-situ analysis of MALDI-TOF MS does not involve subsequent high-resolution mass analyses and sample preparation steps. This method allowed the detection of species-specific biomarkers from each Bacillus spores. Especially, B. anthracis spores had specific biomarker peaks at 2503, 3089, 3376, 6684, 6698, 6753, and 6840 m/z. Cluster and PCA analyses of the mass spectra of Bacillus spores revealed distinctively separated clusters and within-groups similarity. Therefore, we believe that this method is effective in the real-time identification of biological warfare agents such as B. anthracis as well as other microorganisms in the field.

  13. Implementation of dipolar direct current (DDC) collision-induced dissociation in storage and transmission modes on a quadrupole/time-of-flight tandem mass spectrometer.

    Science.gov (United States)

    Webb, Ian K; Londry, Frank A; McLuckey, Scott A

    2011-09-15

    Means for effecting dipolar direct current collision-induced dissociation (DDC CID) on a quadrupole/time-of-flight in a mass spectrometer have been implemented for the broadband dissociation of a wide range of analyte ions. The DDC fragmentation method in electrodynamic storage and transmission devices provides a means for inducing fragmentation of ions over a large mass-to-charge range simultaneously. It can be effected within an ion storage step in a quadrupole collision cell that is operated as a linear ion trap or as ions are continuously transmitted through the collision cell. A DDC potential is applied across one pair of rods in the quadrupole collision cell of a QqTOF hybrid mass spectrometer to effect fragmentation. In this study, ions derived from a small drug molecule, a model peptide, a small protein, and an oligonucleotide were subjected to the DDC CID method in either an ion trapping or an ion transmission mode (or both). Several key experimental parameters that affect DDC CID results, such as time, voltage, low mass cutoff, and bath gas pressure, are illustrated with protonated leucine enkephalin. The DDC CID dissociation method gives a readily tunable, broadband tool for probing the primary structures of a wide range of analyte ions. The method provides an alternative to the narrow resonance conditions of conventional ion trap CID and it can access more extensive sequential fragmentation, depending upon conditions. The DDC CID approach constitutes a collision analog to infrared multiphoton dissociation (IRMPD). Copyright © 2011 John Wiley & Sons, Ltd.

  14. Nuclear waste in a repository: amount as a factor in risk duration

    International Nuclear Information System (INIS)

    Zen, E.

    1980-01-01

    The relationship between the amount of nuclear waste in a nuclear repository and the safety of the repository is examined. It is shown that the amount of a given hazardous nuclide that is potentially leachable depends on the initial amount of waste in the repository and the time that has elapsed since the repository was put into operation. Nuclear repository safety can be enhanced if repositories are designed as modular units with leach-resistant watertight compartments

  15. Direct blood culturing on solid medium outperforms an automated continuously monitored broth-based blood culture system in terms of time to identification and susceptibility testing

    Directory of Open Access Journals (Sweden)

    E.A. Idelevich

    2016-03-01

    Full Text Available Pathogen identification and antimicrobial susceptibility testing (AST should be available as soon as possible for patients with bloodstream infections. We investigated whether a lysis-centrifugation (LC blood culture (BC method, combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS identification and Vitek 2 AST, provides a time advantage in comparison with the currently used automated broth-based BC system. Seven bacterial reference strains were added each to 10 mL human blood in final concentrations of 100, 10 and 1 CFU/mL. Inoculated blood was added to the Isolator 10 tube and centrifuged at 3000 g for 30 min, then 1.5 mL sediment was distributed onto five 150-mm agar plates. Growth was observed hourly and microcolonies were subjected to MALDI-TOF MS and Vitek 2 as soon as possible. For comparison, seeded blood was introduced into an aerobic BC bottle and incubated in the BACTEC 9240 automated BC system. For all species/concentration combinations except one, successful identification and Vitek 2 inoculation were achieved even before growth detection by BACTEC. The fastest identification and inoculation for AST were achieved with Escherichia coli in concentrations of 100 CFU/mL and 10 CFU/mL (after 7 h each, while BACTEC flagged respective samples positive after 9.5 h and 10 h. Use of the LC-BC method allows skipping of incubation in automated BC systems and, used in combination with rapid diagnostics from microcolonies, provides a considerable advantage in time to result. This suggests that the usefulness of direct BC on solid medium should be re-evaluated in the era of rapid microbiology.

  16. Direct analysis by time-of-flight secondary ion mass spectrometry reveals action of bacterial laccase-mediator systems on both hardwood and softwood samples.

    Science.gov (United States)

    Goacher, Robyn E; Braham, Erick J; Michienzi, Courtney L; Flick, Robert M; Yakunin, Alexander F; Master, Emma R

    2017-12-29

    The modification and degradation of lignin play a vital role in carbon cycling as well as production of biofuels and bioproducts. The possibility of using bacterial laccases for the oxidation of lignin offers a route to utilize existing industrial protein expression techniques. However, bacterial laccases are most frequently studied on small model compounds that do not capture the complexity of lignocellulosic materials. This work studied the action of laccases from Bacillus subtilis and Salmonella typhimurium (EC 1.10.3.2) on ground wood samples from yellow birch (Betula alleghaniensis) and red spruce (Picea rubens). The ability of bacterial laccases to modify wood can be facilitated by small molecule mediators. Herein, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), gallic acid and sinapic acid mediators were tested. Direct analysis of the wood samples was achieved by time-of-flight secondary ion mass spectrometry (ToF-SIMS), a surface sensitive mass spectrometry technique that has characteristic peaks for H, G and S lignin. The action of the bacterial laccases on both wood samples was demonstrated and revealed a strong mediator influence. The ABTS mediator led to delignification, evident in an overall increase of polysaccharide peaks in the residual solid, along with equal loss of G and S-lignin peaks. The gallic acid mediator demonstrated minimal lacc