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Sample records for dipsacaceae puzzle primary

  1. Towards resolving the Knautia arvensis agg. (Dipsacaceae) puzzle: primary and secondary contact zones and ploidy segregation at landscape and microgeographic scales

    Czech Academy of Sciences Publication Activity Database

    Kolář, F.; Štech, M.; Trávníček, Pavel; Rauchová, Jana; Urfus, Tomáš; Vít, Petr; Kubešová, Magdalena; Suda, Jan

    2009-01-01

    Roč. 103, č. 6 (2009), s. 963-974 ISSN 0305-7364 R&D Projects: GA AV ČR(CZ) KJB601110627 Institutional research plan: CEZ:AV0Z60050516 Keywords : Knautia arvensis * polyploidy * ploidy mixture Subject RIV: EF - Botanics Impact factor: 3.501, year: 2009

  2. Diversification of CYCLOIDEA-like genes in Dipsacaceae (Dipsacales: implications for the evolution of capitulum inflorescences

    Directory of Open Access Journals (Sweden)

    Carlson Sara E

    2011-11-01

    Full Text Available Abstract Background CYCLOIDEA (CYC-like genes have been implicated in the development of capitulum inflorescences (i.e. flowering heads in Asteraceae, where many small flowers (florets are packed tightly into an inflorescence that resembles a single flower. Several rounds of duplication of CYC-like genes have occurred in Asteraceae, and this is hypothesized to be correlated with the evolution of the capitulum, which in turn has been implicated in the evolutionary success of the group. We investigated the evolution of CYC-like genes in Dipsacaceae (Dipsacales, a plant clade in which capitulum inflorescences originated independently of Asteraceae. Two main inflorescence types are present in Dipsacaceae: (1 radiate species contain two kinds of floret within the flowering head (disk and ray, and (2 discoid species contain only disk florets. To test whether a dynamic pattern of gene duplication, similar to that documented in Asteraceae, is present in Dipsacaceae, and whether these patterns are correlated with different inflorescence types, we inferred a CYC-like gene phylogeny for Dipsacaceae based on representative species from the major lineages. Results We recovered within Dipsacaceae the three major forms of CYC-like genes that have been found in most core eudicots, and identified several additional duplications within each of these clades. We found that the number of CYC-like genes in Dipsacaceae is similar to that reported for members of Asteraceae and that the same gene lineages (CYC1-like and CYC2B-like genes have duplicated in a similar fashion independently in both groups. The number of CYC-like genes recovered for radiate versus discoid species differed, with discoid species having fewer copies of CYC1-like and CYC2B-like genes. Conclusions CYC-like genes have undergone extensive duplication in Dipsacaceae, with radiate species having more copies than discoid species, suggesting a potential role for these genes in the evolution of disk and

  3. Puzzling Mechanisms

    Science.gov (United States)

    van Deventer, M. Oskar

    2009-01-01

    The basis of a good mechanical puzzle is often a puzzling mechanism. This article will introduce some new puzzling mechanisms, like two knots that engage like gears, a chain whose links can be interchanged, and flat gears that do not come apart. It illustrates how puzzling mechanisms can be transformed into real mechanical puzzles, e.g., by…

  4. The Puzzle of HCN in Comets: Is it both a Product and a Primary Species?

    Science.gov (United States)

    Mumma, Michael J.; Bonev, Boncho P.; Charnley, Steven B.; Cordiner, Martin A.; DiSanti, Michael A.; Gibb, Erika L.; Magee-Sauer, Karen; Paganini, Lucas; Villanueva, Geronimo L.

    2014-11-01

    Hydrogen cyanide has long been regarded as a primary volatile in comets, stemming from its presence in dense molecular cloud cores and its supposed storage in the cometary nucleus. Here, we examine the observational evidence for and against that hypothesis, and argue that HCN may also result from near-nucleus chemical reactions in the coma. The distinction (product vs. primary species) is important for multiple reasons: 1. HCN is often used as a proxy for water when the dominant species (H2O) is not available for simultaneous measurement, as at radio wavelengths. 2. HCN is one of the few volatile carriers of nitrogen accessible to remote sensing. If HCN is mainly a product species, its precursor becomes the more important metric for compiling a taxonomic classification based on nitrogen chemistry. 3. The stereoisomer HNC is now confirmed as a product species. Could reaction of a primary precursor (X-CN) with a hydrocarbon co-produce both HNC and HCN? 4. The production rate for CN greatly exceeds that of HCN in some comets, demonstrating the presence of another (more important) precursor of CN. Several puzzling lines of evidence raise issues about the origin of HCN: a. The production rates of HCN measured through rotational (radio) and vibrational (infrared) spectroscopy agree in some comets - in others the infrared rate exceeds the radio rate substantially. b. With its strong dipole moment and H-bonding character, HCN should be linked more strongly in the nuclear ice to other molecules with similar properties (H2O, CH3OH), but instead its spatial release in some comets seems strongly coupled to volatiles that lack a dipole moment and thus do not form H-bonds (methane, ethane). c. The nucleus-centered rotational temperatures measured for H2O and other species (C2H6, CH3OH) usually agree within error, but those for HCN are often slightly smaller. d. In comet ISON, ALMA maps of HCN and the dust continuum show a slight displacement 80 km) in the centroids. We will

  5. Bringing together evolution on serpentine and polyploidy: spatiotemporal history of the diploid-tetraploid complex of Knautia arvensis (Dipsacaceae.

    Directory of Open Access Journals (Sweden)

    Filip Kolář

    Full Text Available Polyploidization is one of the leading forces in the evolution of land plants, providing opportunities for instant speciation and rapid gain of evolutionary novelties. Highly selective conditions of serpentine environments act as an important evolutionary trigger that can be involved in various speciation processes. Whereas the significance of both edaphic speciation on serpentine and polyploidy is widely acknowledged in plant evolution, the links between polyploid evolution and serpentine differentiation have not yet been examined. To fill this gap, we investigated the evolutionary history of the perennial herb Knautia arvensis (Dipsacaceae, a diploid-tetraploid complex that exhibits an intriguing pattern of eco-geographic differentiation. Using plastid DNA sequencing and AFLP genotyping of 336 previously cytotyped individuals from 40 populations from central Europe, we unravelled the patterns of genetic variation among the cytotypes and the edaphic types. Diploids showed the highest levels of genetic differentiation, likely as a result of long term persistence of several lineages in ecologically distinct refugia and/or independent immigration. Recurrent polyploidization, recorded in one serpentine island, seems to have opened new possibilities for the local serpentine genotype. Unlike diploids, the serpentine tetraploids were able to escape from the serpentine refugium and spread further; this was also attributable to hybridization with the neighbouring non-serpentine tetraploid lineages. The spatiotemporal history of K. arvensis allows tracing the interplay of polyploid evolution and ecological divergence on serpentine, resulting in a complex evolutionary pattern. Isolated serpentine outcrops can act as evolutionary capacitors, preserving distinct karyological and genetic diversity. The serpentine lineages, however, may not represent evolutionary 'dead-ends' but rather dynamic systems with a potential to further influence the surrounding

  6. Phthalate Puzzle

    Indian Academy of Sciences (India)

    Abstract. The most common plasticizer, phthalates, are facing stricterregulations due to their omnipresence and possible effects onhuman health, and environment. But high cost, lack of applicationrange, and unknown long-term effects of non-phthalatealternatives make the scenario puzzling.

  7. Idea Puzzle

    OpenAIRE

    Parente, C.; Ferro, L.

    2016-01-01

    WOS:000387124100017 (Nº de Acesso Web of Science) The Idea Puzzle is a software application created in 2007. It is a support tool to assist PhD students and researchers in the process of designing research projects through a focus on three central dimensions of research that are collectively represented by a triangle. Each side of the Idea Puzzle triangle corresponds to one of the three dimensions that every empirical research project should ideally include: ontology (data), epistemology (...

  8. Malaysian primary care doctors' views on men's health: an unresolved jigsaw puzzle.

    Science.gov (United States)

    Tong, Seng Fah; Low, Wah Yun; Ismail, Shaiful Bahari; Trevena, Lyndal; Willcock, Simon

    2011-05-12

    Men have been noted to utilise health care services less readily then women. Primary care settings provide an opportunity to engage men in health care activities because of close proximity to the target group (men in the community). Understanding attitudes towards men's health among Malaysian primary care doctors is important for the effective delivery of health services to men. We aimed to explore the opinions and attitudes of primary care doctors (PCDs) relating to men's health and help-seeking behaviour. A qualitative approach to explore the opinions of 52 PCDs was employed, using fourteen in-depth interviews and eight focus group discussions in public and private settings. Purposive sampling of PCDs was done to ensure maximum variation in the PCD sample. Interviews were recorded and transcribed verbatim for analysis. Open coding with thematic analysis was used to identify key issues raised in the interview. The understanding of the concept of men's health among PCDs was fragmented. Although many PCDs were already managing health conditions relevant and common to men, they were not viewed by PCDs as "men's health". Less attention was paid to men's help-seeking behaviour and their gender roles as a potential determinant of the poor health status of men. There were opposing views about whether men's health should focus on men's overall health or a more focused approach to sexual health. There was also disagreement about whether special attention was warranted for men's health services. Some doctors would prioritise more common conditions such as hypertension, diabetes and hypercholesterolaemia. The concept of men's health was new to PCDs in Malaysia. There was wide variation in understanding and opposing attitudes towards men's health among primary care doctors. Creating awareness and having a systematic approach would facilitate PCDs in delivering health service to men.

  9. Malaysian primary care doctors' views on men's health: an unresolved jigsaw puzzle

    Directory of Open Access Journals (Sweden)

    Ismail Shaiful

    2011-05-01

    Full Text Available Abstract Background Men have been noted to utilise health care services less readily then women. Primary care settings provide an opportunity to engage men in health care activities because of close proximity to the target group (men in the community. Understanding attitudes towards men's health among Malaysian primary care doctors is important for the effective delivery of health services to men. We aimed to explore the opinions and attitudes of primary care doctors (PCDs relating to men's health and help-seeking behaviour. Methods A qualitative approach to explore the opinions of 52 PCDs was employed, using fourteen in-depth interviews and eight focus group discussions in public and private settings. Purposive sampling of PCDs was done to ensure maximum variation in the PCD sample. Interviews were recorded and transcribed verbatim for analysis. Open coding with thematic analysis was used to identify key issues raised in the interview. Results The understanding of the concept of men's health among PCDs was fragmented. Although many PCDs were already managing health conditions relevant and common to men, they were not viewed by PCDs as "men's health". Less attention was paid to men's help-seeking behaviour and their gender roles as a potential determinant of the poor health status of men. There were opposing views about whether men's health should focus on men's overall health or a more focused approach to sexual health. There was also disagreement about whether special attention was warranted for men's health services. Some doctors would prioritise more common conditions such as hypertension, diabetes and hypercholesterolaemia. Conclusions The concept of men's health was new to PCDs in Malaysia. There was wide variation in understanding and opposing attitudes towards men's health among primary care doctors. Creating awareness and having a systematic approach would facilitate PCDs in delivering health service to men.

  10. Deductive Puzzling

    Science.gov (United States)

    Wanko, Jeffrey J.

    2010-01-01

    To help fifth- through eighth-grade students develop their deductive reasoning skills, the author used a ten-week supplementary curriculum so that students could answer logic questions. The curriculum, a series of lessons built around language-independent logic puzzles, has been used in classrooms of fifth through eighth grades. In most cases,…

  11. Incomplete Puzzle

    Science.gov (United States)

    2006-01-01

    15 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a mid-summer view of a portion of the south polar residual cap of Mars. The large, relatively flat-lying, puzzle-like pieces in this scene are mesas composed largely of solid carbon dioxide. Location near: 85.5oS, 76.8oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

  12. Isotope puzzle in sputtering

    International Nuclear Information System (INIS)

    Zheng Liping

    1998-01-01

    Mechanisms affecting multicomponent material sputtering are complex. Isotope sputtering is the simplest in the multicomponent materials sputtering. Although only mass effect plays a dominant role in the isotope sputtering, there is still an isotope puzzle in sputtering by ion bombardment. The major arguments are as follows: (1) At the zero fluence, is the isotope enrichment ejection-angle-independent or ejection-angle-dependent? (2) Is the isotope angular effect the primary or the secondary sputter effect? (3) How to understand the action of momentum asymmetry in collision cascade on the isotope sputtering?

  13. Solving a binary puzzle

    NARCIS (Netherlands)

    Utomo, P.H.; Makarim, R.H.

    2017-01-01

    A Binary puzzle is a Sudoku-like puzzle with values in each cell taken from the set {0,1} {0,1}. Let n≥4 be an even integer, a solved binary puzzle is an n×n binary array that satisfies the following conditions: (1) no three consecutive ones and no three consecutive zeros in each row and each

  14. Tangrams: Puzzles of Art

    Science.gov (United States)

    Fee, Brenda

    2009-01-01

    Challenging one's brain is the beginning of making great art. Tangrams are a great way to keep students thinking about their latest art project long after leaving the classroom. A tangram is a Chinese puzzle. The earliest known reference to tangrams appears in a Chinese book dated 1813, but the puzzles existed long before that date. The puzzle…

  15. The Anatomy Puzzle Book.

    Science.gov (United States)

    Jacob, Willis H.; Carter, Robert, III

    This document features review questions, crossword puzzles, and word search puzzles on human anatomy. Topics include: (1) Anatomical Terminology; (2) The Skeletal System and Joints; (3) The Muscular System; (4) The Nervous System; (5) The Eye and Ear; (6) The Circulatory System and Blood; (7) The Respiratory System; (8) The Urinary System; (9) The…

  16. New Sliding Puzzle with Neighbors Swap Motion

    OpenAIRE

    Prihardono, Ariyanto; Kawagoe, Kenichi

    2015-01-01

    The sliding puzzles (15-puzzle, 8-puzzle, 5-puzzle) are known to have 2 kind of puz-zle: solvable puzzle and unsolvable puzzle. In this thesis, we make a new puzzle with only 1 kind of it, solvable puzzle. This new puzzle is made by adopting sliding puzzle with several additional rules from M13 puzzle; the puzzle that is formed form The Mathieu group M13. This puzzle has a movement that called a neighbors swap motion, a rule of movement that enables every neighboring points to swap. This extr...

  17. Blood Type Puzzle.

    Science.gov (United States)

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  18. The Entrepreneurial Earnings Puzzle

    DEFF Research Database (Denmark)

    Chen, Jing; Åstebro, Thomas

    2014-01-01

    A review of recent evidence on relative earnings from entrepreneurship versus wage work presents a puzzle: why do individuals become entrepreneurs when entrepreneurs on average apparently earn less than employees? After considering several potential explanations, we empirically analyze one: income...

  19. The PPP Puzzle

    DEFF Research Database (Denmark)

    Juselius, Katarina

    The persistent movements away from long-run benchmark values in real exchange rates, dubbed the PPP puzzle, observed in many real exchange rates during periods of currency float have been subject to much empirical research without resolving the puzzle. The paper demonstrates how the cointegrated...... VAR approach by grouping together components of similar persistence can be used to uncover structures in the data that ultimately may help to explain theoretically the forces underlying such puzzling movements. The charaterization of the data into components which are empirically I(0), I(1), and I(2......) is shown to be a powerful organizing principle allowing us to structure the data in long-run, medium-run, and short-run behavior. Its main advantage is the ability to associate persistent movements away from fundamental benchmark values in one variable/relation with similar persistent movements somewhere...

  20. On IBM's Millennial Puzzle

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 10. On IBM's Millennial Puzzle. A Sarangarajan. Classroom Volume 5 Issue 10 October 2000 pp 81-89. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/005/10/0081-0089. Author Affiliations.

  1. Idiosyncratic Volatility Puzzle

    DEFF Research Database (Denmark)

    Aslanidis, Nektarios; Christiansen, Charlotte; Lambertides, Neophytos

    from a large pool of macroeconomic and Önancial variables. Cleaning for macro-Önance e§ects reverses the puzzling negative relation between returns and idiosyncratic volatility documented previously. Portfolio analysis shows that the e§ects from macro-Önance factors are economically strong...

  2. Puzzles in B physics

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 67; Issue 5. Puzzles in physics. Hsiang-Nan Li ... Author Affiliations. Hsiang-Nan Li1 2. Institute of Physics, Academia Sinica, Taipei, Taiwan 115, Republic of China; Department of Physics, National Cheng-Kung University, Tainan, Taiwan 701, Republic of China ...

  3. La Francophonie. Puzzle Corner.

    Science.gov (United States)

    Andrews, Ian A.

    2000-01-01

    Discusses the organization La Francophonie, which is an international community of people who speak French and convene to address issues. Presents a crossword puzzle that introduces readers to some of the nations involved in La Francophonie. Provides the across and down clues, a word list, and answer key. (CMK)

  4. Nature's Greatest Puzzles

    International Nuclear Information System (INIS)

    Quigg, Chris

    2005-01-01

    It is a pleasure to be part of the SLAC Summer Institute again, not simply because it is one of the great traditions in our field, but because this is a moment of great promise for particle physics. I look forward to exploring many opportunities with you over the course of our two weeks together. My first task in talking about Nature's Greatest Puzzles, the title of this year's Summer Institute, is to deconstruct the premise a little bit

  5. Solving the BM Camelopardalis puzzle

    Science.gov (United States)

    Teke, Mathias; Busby, Michael R.; Hall, Douglas S.

    1989-01-01

    BM Camelopardalis (=12 Cam) is a chromospherically active binary star with a relatively large orbital eccentricity. Systems with large eccentricities usually rotate pseudosynchronously. However, BM Cam has been a puzzle since its observed rotation rate is virtually equal to its orbital period indicating synchronization. All available photometry data for BM Cam have been collected and analyzed. Two models of modulated ellipticity effect are proposed, one based on equilibrium tidal deformation of the primary star and the other on a dynamical tidal effect. When the starspot variability is removed from the data, the dynamical tidal model was the better approximation to the real physical situation. The analysis indicates that BM Cam is not rotating pseudosynchronously but rotating in virtual synchronism after all.

  6. The infinity puzzle

    CERN Document Server

    Close, Frank

    2011-01-01

    We are living in a Golden Age of Physics. Forty or so years ago, three brilliant, yet little-known scientists - an American, a Dutchman, and an Englishman - made breakthroughs which later inspired the construction of the Large Hadron Collider at CERN in Geneva: a 27 kilometer-long machine which has already costs ten billion dollars, taken twenty years to build, and now promises to reveal how the universe itself came to be. The Infinity Puzzle is the inside story of those forty years of research, breakthrough, and endeavour. Peter Higgs, Gerard 't Hooft and James Bjorken, were the three scienti

  7. Musings on the puzzle piece.

    Science.gov (United States)

    Goin-Kochel, Robin P

    2016-02-01

    Following is a brief musing on Roy Grinker's discussion of what the puzzle piece symbolizes for autism during his presentation at the 2015 International Meeting for Autism Research. In his words, "The puzzle piece is ubiquitous." It likely holds a different meaning for each of us, and this is how one autism researcher sees it. © The Author(s) 2015.

  8. Basic Functional Analysis Puzzles of Spectral Flow

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm

    2011-01-01

    We explain an array of basic functional analysis puzzles on the way to general spectral flow formulae and indicate a direction of future topological research for dealing with these puzzles.......We explain an array of basic functional analysis puzzles on the way to general spectral flow formulae and indicate a direction of future topological research for dealing with these puzzles....

  9. The proton radius puzzle

    Science.gov (United States)

    Bonesini, Maurizio

    2017-12-01

    The FAMU (Fisica degli Atomi Muonici) experiment has the goal to measure precisely the proton Zemach radius, thus contributing to the solution of the so-called proton radius "puzzle". To this aim, it makes use of a high-intensity pulsed muon beam at RIKEN-RAL impinging on a cryogenic hydrogen target with an high-Z gas admixture and a tunable mid-IR high power laser, to measure the hyperfine (HFS) splitting of the 1S state of the muonic hydrogen. From the value of the exciting laser frequency, the energy of the HFS transition may be derived with high precision ( 10-5) and thus, via QED calculations, the Zemach radius of the proton. The experimental apparatus includes a precise fiber-SiPMT beam hodoscope and a crown of eight LaBr3 crystals and a few HPGe detectors for detection of the emitted characteristic X-rays. Preliminary runs to optimize the gas target filling and its operating conditions have been taken in 2014 and 2015-2016. The final run, with the pump laser to drive the HFS transition, is expected in 2018.

  10. The birth order puzzle.

    Science.gov (United States)

    Zajonc, R B; Markus, H; Markus, G B

    1979-08-01

    Studies relating intellectual performance to birth order report conflicting results, some finding intellectual scores to increase, others to decrease with birth order. In contrast, the relationship between intellectual performance and family size is stable and consistently replicable. Why do these two highly related variables generate such divergent results? This birth order puzzle is resolved by means of the confluence model that quantifies the influences upon intellectual growth arising within the family context. At the time of a new birth, two opposing influences act upon intellectual growth of the elder sibling: (a) his or her intellectual environment is "diluted" and (b) he or she loses the "last-born's handicap" and begins serving as an intellectual resource to the younger sibling. Since these opposite effects are not equal in magnitude, the differences in intellectual performance among birth ranks are shown to be age dependent. While elder children may surpass their younger siblings in intellectual performance at some ages, they may be overtaken by them at others. Thus when age is taken into consideration, the birth order literature loses its chaotic character and an orderly pattern of results emerges.

  11. Current puzzles in nuclear physics

    International Nuclear Information System (INIS)

    1985-01-01

    A meeting on ''Current puzzles in nuclear physics'' was held at Research Center for Nuclear Physics, Osaka University, on June 27 - 28, 1984. The meeting put emphasis on several puzzles which have not been solved for a long time in nuclear physics, and also on the puzzles. This collective report is composed of following eleven papers presented at the meeting. Almost all the papers are witten in English : (1) M1, GT excitations and configuration mixing (in Japanese). (2) Hadronic excitation of pionic states. (3) Microscopic analyses of 28 Si(α,α') 28 Si scattering and single particle strength in A = 29 nuclei. (4) Few-body physics and its incentives to nuclear physics. (5) Is it necessary to introduce three body interactions ? (in Japanese). (6) Puzzles in the neutron-deuteron elastic scattering. (7) Puzzles in NN, NΔ, πN and Nanti N interactions. (8) Problems in Hadron-Nucleus interaction. (9) Unified approach to the meson- and quark- theory of nuclear forces and currents. (10) Pion photoproduction in two Chiral bag models. (11) The dynamic bag model : The electromagnetic properties of nucleon. (Aoki, K.)

  12. Astroparticle physics: puzzles and discoveries

    International Nuclear Information System (INIS)

    Berezinsky, V

    2008-01-01

    Puzzles often give birth to the great discoveries, the false discoveries sometimes stimulate the exiting ideas in theoretical physics. The historical examples of both are described in Introduction and in section 'Cosmological Puzzles'. From existing puzzles most attention is given to Ultra High Energy Cosmic Ray (UHECR) puzzle and to cosmological constant problem. The 40-years old UHECR problem consisted in absence of the sharp steepening in spectrum of extragalactic cosmic rays caused by interaction with CMB radiation. This steepening is known as Greisen-Zatsepin-Kuzmin (GZK) cutoff. It is demonstrated here that the features of interaction of cosmic ray protons with CMB are seen now in the spectrum in the form of the dip and beginning of the GZK cutoff. The most serious cosmological problem is caused by large vacuum energy of the known elementary-particle fields which exceeds at least by 45 orders of magnitude the cosmological vacuum energy. The various ideas put forward to solve this problem during last 40 years, have weaknesses and cannot be accepted as the final solution of this puzzle. The anthropic approach is discussed

  13. Children's Task Engagement during Challenging Puzzle Tasks

    Science.gov (United States)

    Wang, Feihong; Algina, James; Snyder, Patricia; Cox, Martha

    2017-01-01

    We examined children's task engagement during a challenging puzzle task in the presence of their primary caregivers by using a representative sample of rural children from six high-poverty counties across two states. Weighted longitudinal confirmatory factor analysis and structural equation modeling were used to identify a task engagement factor…

  14. Imaginary Cubes and Their Puzzles

    Directory of Open Access Journals (Sweden)

    Hideki Tsuiki

    2012-05-01

    Full Text Available Imaginary cubes are three dimensional objects which have square silhouette projections in three orthogonal ways just as a cube has. In this paper, we study imaginary cubes and present assembly puzzles based on them. We show that there are 16 equivalence classes of minimal convex imaginary cubes, among whose representatives are a hexagonal bipyramid imaginary cube and a triangular antiprism imaginary cube. Our main puzzle is to put three of the former and six of the latter pieces into a cube-box with an edge length of twice the size of the original cube. Solutions of this puzzle are based on remarkable properties of these two imaginary cubes, in particular, the possibility of tiling 3D Euclidean space.

  15. Famous puzzles of great mathematicians

    CERN Document Server

    Petković, Miodrag S

    2009-01-01

    This entertaining book presents a collection of 180 famous mathematical puzzles and intriguing elementary problems that great mathematicians have posed, discussed, and/or solved. The selected problems do not require advanced mathematics, making this book accessible to a variety of readers. Mathematical recreations offer a rich playground for both amateur and professional mathematicians. Believing that creative stimuli and aesthetic considerations are closely related, great mathematicians from ancient times to the present have always taken an interest in puzzles and diversions. The goal of this

  16. Sleep for Kids: Games and Puzzles

    Science.gov (United States)

    ... and puzzles can help you learn more about sleep! Learn about sleep with this fun crossword puzzle! Test your memory and learn how to get better sleep! Find the hidden sleep words! Avoid things that ...

  17. Do Puzzle Pieces and Autism Puzzle Piece Logos Evoke Negative Associations?

    Science.gov (United States)

    Gernsbacher, Morton Ann; Raimond, Adam R.; Stevenson, Jennifer L.; Boston, Jilana S.; Harp, Bev

    2018-01-01

    Puzzle pieces have become ubiquitous symbols for autism. However, puzzle-piece imagery stirs debate between those who support and those who object to its use because they believe puzzle-piece imagery evokes negative associations. Our study empirically investigated whether puzzle pieces evoke negative associations in the general public.…

  18. À chacun son puzzle

    Directory of Open Access Journals (Sweden)

    Jean-Noël Ferrié

    2012-05-01

    Full Text Available Le texte soutient que le « tournant naturaliste » que l’on nous invite à négocier ne donne aucun moyen supplémentaire pour parvenir à une description perspicace de ce que les gens font dans des circonstances précises, l’existence humaine pouvant être considérée comme une collection de circonstances précises. Sans doute le naturalisme nous permet-il de comprendre comment certaines actions humaines sont possibles, mais cela ne nous dit pas pourquoi et comment elles font sens pour tout un chacun. La méthodologie nécessaire pour éclaircir le premier point obscurcit généralement le second. Le mieux est donc de considérer que les deux approches ne vont pas de pair. Ce point de vue est soutenu à partir d’exemple tirés de l’anthropologie de la religion.To each one his puzzle. For a serene methodological pluralismThe text argues that the « naturalistic turn » that we are invited to negotiate does not give any additional means to achieve an insightful description of what people do in specific circumstances, and human existence can be considered as a collection of specific circumstances. Probably naturalism allows us to understand how some human actions are possible, but that does not tell us why and how they make sense for everyone. The methodology needed to clarify the first point usually obscures the second one. The best way is to consider that the two approaches do not go together. The text supports this view from an example drawn from the anthropology of religion.A cada uno su rompecabezas. En favor de un pluralismo metodológico serenoEl texto argumenta que la inflexión naturalista a la que se nos invita a participar no proporciona ningún medio suplementario que desemboque en una descripción perspicaz de lo que la gente hace en circunstancias concretas ya que la existencia humana puede ser considerada como una concatenación de circunstancias concretas. Sin duda el naturalismo nos permite comprender como son

  19. Teaching Inductive Reasoning with Puzzles

    Science.gov (United States)

    Wanko, Jeffrey J.

    2017-01-01

    Working with language-independent logic structures can help students develop both inductive and deductive reasoning skills. The Japanese publisher Nikoli (with resources available both in print and online) produces a treasure trove of language-independent logic puzzles. The Nikoli print resources are mostly in Japanese, creating the extra…

  20. The Puzzle of Coherence

    DEFF Research Database (Denmark)

    Andersen, Anne Bendix; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    Background During the past decade, politicians and healthcare providers have strived to create a coherent healthcare system across primary and secondary healthcare sectors in Denmark. Nevertheless, elderly patients with chronic diseases (EPCD) continue to report experiences of poor-quality care a...

  1. The Puzzle of Coherence

    DEFF Research Database (Denmark)

    Andersen, Anne Bendix; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    During the past decade, politicians and health care providers have strived to create a coherent health care system across primary and secondary health care systems in Denmark. Nevertheless, elderly patients with chronic diseases (EPCD) continue to report experiences of poor-quality care and lack ...... both nationally and internationally in preparation of health agreements, implementation of new collaboration forms among health care providers, and in improvement of delegation and transfer of information and assignments across sectors in health care....

  2. Current puzzles and future possibilities

    International Nuclear Information System (INIS)

    Nagamiya, S.

    1982-02-01

    Four current puzzles and several future experimental possibilities in high-energy nuclear collision research are discussed. These puzzles are (1) entropy, (2) hydrodynamic flow, (3) anomalon, and (4) particle emission at backward angles in proton-nucleus collisions. The last one seems not to be directly related to the subject of the present school. But it is, because particle emission into the region far beyond the nucleon-nucleon kinematical limit is an interesting subject common for both proton-nucleus and nucleus-nucleus collisions, and the basic mechanism involved is strongly related in these two cases. Future experimental possibilities are described which include: (1) possibilities of studying multibaryonic excited states, (2) applications of neutron-rich isotopes, and (3) other needed experimental tasks. 72 references

  3. Neutron star news and puzzles

    International Nuclear Information System (INIS)

    Prakash, Madappa

    2014-01-01

    Gerry Brown has had the most influence on my career in Physics, and my life after graduate studies. This article gives a brief account of some of the many ways in which Gerry shaped my research. Focus is placed on the significant strides on neutron star research made by the group at Stony Brook, which Gerry built from scratch. Selected puzzles about neutron stars that remain to be solved are noted

  4. Construction-Paper Puzzle Masterpieces

    Science.gov (United States)

    Vance, Shelly

    2010-01-01

    Creating an appreciation of art history in her junior-high students has always been one of the author's greatest challenges as an art teacher. In this article, the author describes how her eighth-grade students re-created a famous work of art--piece by piece, like a puzzle or a stained-glass window--out of construction paper. (Contains 1 resource.)

  5. Puzzles of large scale structure and gravitation

    International Nuclear Information System (INIS)

    Sidharth, B.G.

    2006-01-01

    We consider the puzzle of cosmic voids bounded by two-dimensional structures of galactic clusters as also a puzzle pointed out by Weinberg: How can the mass of a typical elementary particle depend on a cosmic parameter like the Hubble constant? An answer to the first puzzle is proposed in terms of 'Scaled' Quantum Mechanical like behaviour which appears at large scales. The second puzzle can be answered by showing that the gravitational mass of an elementary particle has a Machian character (see Ahmed N. Cantorian small worked, Mach's principle and the universal mass network. Chaos, Solitons and Fractals 2004;21(4))

  6. The puzzle of neutron lifetime

    International Nuclear Information System (INIS)

    Paul, Stephan

    2009-01-01

    In this paper we review the role of the neutron lifetime and discuss the present status of measurements. In view of the large discrepancy observed by the two most precise individual measurements so far we describe the different techniques and point out the principle strengths and weaknesses. In particular we discuss the estimation of systematic uncertainties and its correlation to the statistical ones. In order to solve the present puzzle, many new experiments are either ongoing or being proposed. An overview on their possible contribution to this field will be given.

  7. The Magnets Puzzle is NP-Complete

    DEFF Research Database (Denmark)

    Kölker, Jonas

    2012-01-01

    In a Magnets puzzle, one must pack magnets in a box subjet to polarity and numeric constraints. We show that solvability of Magnets instances is NP-complete.......In a Magnets puzzle, one must pack magnets in a box subjet to polarity and numeric constraints. We show that solvability of Magnets instances is NP-complete....

  8. Hadronic decay puzzle in charmonium physics

    International Nuclear Information System (INIS)

    Gu Yifan

    1996-01-01

    Recent experimental results obtained at Beijing Electron-proton Collider sensitivity level the crisply defined nature of the hadronic decay puzzle in charmonium physics. Discovery of new anomalous decay modes breaks with the previously established pattern of the puzzle, and poses new challenges for its theoretical understanding

  9. The RPA Atomization Energy Puzzle.

    Science.gov (United States)

    Ruzsinszky, Adrienn; Perdew, John P; Csonka, Gábor I

    2010-01-12

    There is current interest in the random phase approximation (RPA), a "fifth-rung" density functional for the exchange-correlation energy. RPA has full exact exchange and constructs the correlation with the help of the unoccupied Kohn-Sham orbitals. In many cases (uniform electron gas, jellium surface, and free atom), the correction to RPA is a short-ranged effect that is captured by a local spin density approximation (LSDA) or a generalized gradient approximation (GGA). Nonempirical density functionals for the correction to RPA were constructed earlier at the LSDA and GGA levels (RPA+), but they are constructed here at the fully nonlocal level (RPA++), using the van der Waals density functional (vdW-DF) of Langreth, Lundqvist, and collaborators. While they make important and helpful corrections to RPA total and ionization energies of free atoms, they correct the RPA atomization energies of molecules by only about 1 kcal/mol. Thus, it is puzzling that RPA atomization energies are, on average, about 10 kcal/mol lower than those of accurate values from experiment. We find here that a hybrid of 50% Perdew-Burke-Ernzerhof GGA with 50% RPA+ yields atomization energies much more accurate than either one does alone. This suggests a solution to the puzzle: While the proper correction to RPA is short-ranged in some systems, its contribution to the correlation hole can spread out in a molecule with multiple atomic centers, canceling part of the spread of the exact exchange hole (more so than in RPA or RPA+), making the true exchange-correlation hole more localized than in RPA or RPA+. This effect is not captured even by the vdW-DF nonlocality, but it requires the different kind of full nonlocality present in a hybrid functional.

  10. PSQP: Puzzle Solving by Quadratic Programming.

    Science.gov (United States)

    Andalo, Fernanda A; Taubin, Gabriel; Goldenstein, Siome

    2017-02-01

    In this article we present the first effective method based on global optimization for the reconstruction of image puzzles comprising rectangle pieces-Puzzle Solving by Quadratic Programming (PSQP). The proposed novel mathematical formulation reduces the problem to the maximization of a constrained quadratic function, which is solved via a gradient ascent approach. The proposed method is deterministic and can deal with arbitrary identical rectangular pieces. We provide experimental results showing its effectiveness when compared to state-of-the-art approaches. Although the method was developed to solve image puzzles, we also show how to apply it to the reconstruction of simulated strip-shredded documents, broadening its applicability.

  11. The Puzzle of Male Chronophilias.

    Science.gov (United States)

    Seto, Michael C

    2017-01-01

    In this article, I return to the idea that pedophilia, a sexual interest in prepubescent children, can be considered a sexual orientation for age, in conjunction with the much more widely acknowledged and discussed sexual orientation for gender. Here, I broaden the scope to consider other chronophilias, referring to paraphilias for age/maturity categories other than young sexually mature adults. The puzzle of chronophilias includes questions about etiology and course, how chronophilias are related to each other, and what they can tell us about how human (male) sexuality is organized. In this article, I briefly review research on nepiophilia (infant/toddlers), pedophilia (prepubescent children), hebephilia (pubescent children), ephebophilia (postpubescent, sexually maturing adolescents), teleiophilia (young sexually mature adults, typically 20s and 30s), mesophilia (middle-aged adults, typically 40s and 50s), and gerontophilia (elderly adults, typically 60s and older) in the context of a multidimensional sexual orientations framework. Relevant research, limitations, and testable hypotheses for future work are identified.

  12. Multiple sclerosis pathogenesis: missing pieces of an old puzzle.

    Science.gov (United States)

    Rahmanzadeh, Reza; Brück, Wolfgang; Minagar, Alireza; Sahraian, Mohammad Ali

    2018-06-08

    Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studies of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include the following: a primary degenerative process (e.g. oligodendroglial pathology), generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells. Here, we review these findings and discuss their implications in MS pathogenesis.

  13. The Role of Inhibitory Control in Children's Cooperative Behaviors during a Structured Puzzle Task

    Science.gov (United States)

    Giannotta, Fabrizia; Burk, William J.; Ciairano, Silvia

    2011-01-01

    This study examined the role of inhibitory control (measured by Stroop interference) in children's cooperative behaviors during a structured puzzle task. The sample consisted of 250 8-, 10-, and 12-year-olds (117 girls and 133 boys) attending classrooms in three primary schools in Northern Italy. Children individually completed an elaborated…

  14. Modular Extracellular Matrices: Solutions for the Puzzle

    Science.gov (United States)

    Serban, Monica A.; Prestwich, Glenn D.

    2008-01-01

    The common technique of growing cells in two-dimensions (2-D) is gradually being replaced by culturing cells on matrices with more appropriate composition and stiffness, or by encapsulation of cells in three-dimensions (3-D). The universal acceptance of the new 3-D paradigm has been constrained by the absence of a commercially available, biocompatible material that offers ease of use, experimental flexibility, and a seamless transition from in vitro to in vivo applications. The challenge – the puzzle that needs a solution – is to replicate the complexity of the native extracellular matrix (ECM) environment with the minimum number of components necessary to allow cells to rebuild and replicate a given tissue. For use in drug discovery, toxicology, cell banking, and ultimately in reparative medicine, the ideal matrix would therefore need to be highly reproducible, manufacturable, approvable, and affordable. Herein we describe the development of a set of modular components that can be assembled into biomimetic materials that meet these requirements. These semi-synthetic ECMs, or sECMs, are based on hyaluronan derivatives that form covalently crosslinked, biodegradable hydrogels suitable for 3-D culture of primary and stem cells in vitro, and for tissue formation in vivo. The sECMs can be engineered to provide appropriate biological cues needed to recapitulate the complexity of a given ECM environment. Specific applications for different sECM compositions include stem cell expansion with control of differentiation, scar-free wound healing, growth factor delivery, cell delivery for osteochondral defect and liver repair, and development of vascularized tumor xenografts for personalized chemotherapy. PMID:18442709

  15. Status of particle physics solutions to the UHECR puzzle

    International Nuclear Information System (INIS)

    Kachelrieb, M.

    2004-01-01

    The status of solutions to the ultra-high energy cosmic ray (UHECR) puzzle that involve particle physics beyond the standard model is reviewed. Signatures and experimental constraints are discussed for most proposals such as the Z burst model and topological defects (both allowed only as sub-dominant contributions), supermassive dark matter (no positive evidence from its key signatures galactic anisotropy and photon dominance), strongly interacting neutrinos or new primaries (no viable models known), and violation of Lorentz invariance (viable). Lorentz invariance violation should be considered seriously as an explanation for the UHECR puzzle, if there is not a considerable fraction of photon primaries at the highest energies, correlations with sources at cosmological distance can be established, and the spectrum extends well beyond the GZK (Greisen-Zatsepin-Kuzmin) cutoff. If only the two first conditions are found to be true, and the UHECR spectrum is close to the one measured in the HiRes experiment, then bottom-up scenarios are a sufficient explanation for the data

  16. Lepton mixing and the ''solar neutrino puzzle''

    International Nuclear Information System (INIS)

    Bilenky, S.M.; Pontecorvo, B.

    1977-01-01

    The results of the well known solar neutrino experiment of Davis et al. are discussed, in which the Cl-Ar method is used. The result of the experiment, a too small neutrino signal (the so-called ''solar neutrino puzzle'), has been tentatively accounted for in a number of quite exotic explanations. It appears that the explanation in terms of lepton mixing and neutrino sterility is quite attractive from the point of view of present day elementary particle physics and is much more natural than the other explanations of the ''puzzle''

  17. Difficult Sudoku Puzzles Created by Replica Exchange Monte Carlo Method

    OpenAIRE

    Watanabe, Hiroshi

    2013-01-01

    An algorithm to create difficult Sudoku puzzles is proposed. An Ising spin-glass like Hamiltonian describing difficulty of puzzles is defined, and difficult puzzles are created by minimizing the energy of the Hamiltonian. We adopt the replica exchange Monte Carlo method with simultaneous temperature adjustments to search lower energy states efficiently, and we succeed in creating a puzzle which is the world hardest ever created in our definition, to our best knowledge. (Added on Mar. 11, the ...

  18. Puzzle Pedagogy: A Use of Riddles in Mathematics Education

    Science.gov (United States)

    Farnell, Elin

    2017-01-01

    In this article, I present a collection of puzzles appropriate for use in a variety of undergraduate courses, along with suggestions for relevant discussion. Logic puzzles and riddles have long been sources of amusement for mathematicians and the general public alike. I describe the use of puzzles in a classroom setting, and argue for their use as…

  19. Algorithmic Puzzles: History, Taxonomies, and Applications in Human Problem Solving

    Science.gov (United States)

    Levitin, Anany

    2017-01-01

    The paper concerns an important but underappreciated genre of algorithmic puzzles, explaining what these puzzles are, reviewing milestones in their long history, and giving two different ways to classify them. Also covered are major applications of algorithmic puzzles in cognitive science research, with an emphasis on insight problem solving, and…

  20. A Puzzle Guide to Gödel

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 7. Forever Undecided: A Puzzle Guide to Gödel. R Ramanujam. Book Review Volume 6 Issue 7 July 2001 pp 97-98. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/006/07/0097-0098 ...

  1. Solving jigsaw puzzles using image features

    DEFF Research Database (Denmark)

    Nielsen, Ture R.; Drewsen, Peter; Hansen, Klaus

    2008-01-01

    In this article, we describe a method for automatic solving of the jigsaw puzzle problem based on using image features instead of the shape of the pieces. The image features are used for obtaining an accurate measure for edge similarity to be used in a new edge matching algorithm. The algorithm i...

  2. New data and an old puzzle

    DEFF Research Database (Denmark)

    Lee, S Hong; Byrne, Enda M; Hultman, Christina M

    2015-01-01

    BACKGROUND: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one...

  3. A generalization of the Pasadena puzzle

    NARCIS (Netherlands)

    Peterson, M.B.

    2013-01-01

    By generalizing the Pasadena puzzle introduced by Nover and Hájek (2004) we show that the sum total of value produced by an act can be made to converge to any real number by applying the Riemann rearrangement theorem, even if the scenario faced by the decision maker is non-probabilistic and fully

  4. Puzzles in studies of quantum chaos

    International Nuclear Information System (INIS)

    Xu Gongou

    1994-01-01

    Puzzles in studies of quantum chaos are discussed. From the view of global properties of quantum states, it is clarified that quantum chaos originates from the break-down of invariant properties of quantum canonical transformations. There exist precise correspondences between quantum and classical chaos

  5. The Crossword Puzzle as a Teaching Tool.

    Science.gov (United States)

    Crossman, Edward K.

    1983-01-01

    In courses such as the history of psychology, it is necessary to learn a variety of relationships, events, and sequences, in addition to the task of having to pair certain key concepts with related names, e.g., phrenology--Hall. One tool useful in this type of learning is the crossword puzzle. (RM)

  6. Mathematical History: Activities, Puzzles, Stories, and Games.

    Science.gov (United States)

    Mitchell, Merle

    Based on the history of mathematics, these materials have been planned to enrich the teaching of mathematics in grades four, five, and six. Puzzles and games are based on stories about topics such as famous mathematicians, numerals of ancient peoples, and numerology. The sheets are arranged by grade level and are designed for easy duplication.…

  7. Peelle's pertinent puzzle: Way of solution

    International Nuclear Information System (INIS)

    Pronyaev, V.G.

    2003-01-01

    The effect of evident bias of evaluated data below the majority of experimental data observed in general least-squares model fitting of these data is called as Peelle's Pertinent Puzzle (PPP). Since the transformation of the central values is trivial, the solution by transformation of covariance matrices is deducted

  8. Bullet-Block Science Video Puzzle

    Science.gov (United States)

    Shakur, Asif

    2015-01-01

    A science video blog, which has gone viral, shows a wooden block shot by a vertically aimed rifle. The video shows that the block hit dead center goes exactly as high as the one shot off-center. (Fig. 1). The puzzle is that the block shot off-center carries rotational kinetic energy in addition to the gravitational potential energy. This leads a…

  9. Lepton mixing and the 'solar neutrino puzzle'

    International Nuclear Information System (INIS)

    Bilenky, S.M.; Pontecorvo, B.

    1977-01-01

    The results of the well-known solar neutrino experiments in which the Cl-Ar method was employed are discussed; the results of this experiment gave a too-small neutrino signal and were referred to as the 'solar neutrino puzzle'. A number of explanations have been offered to account for the results, but it is stated that the explanation in terms of lepton mixing and neutrino sterility is attractive in terms of present day elementary particle physics and much more natural than the other explanations offered. Headings are as follows: neutrino oscillations and lepton charge, oscillations and solar neutrino experiments, lepton mixing according to old and present ideas, neutrino oscillations and the 'solar neutrino puzzle'. (U.K.)

  10. Mankiw's Puzzle on Consumer Durables: A Misspecification

    OpenAIRE

    Tam Bang Vu

    2005-01-01

    Mankiw (1982) shows that consumer durables expenditures should follow a linear ARMA(1,1) process, but the data analyzed supports an AR(1) process instead; thus, a puzzle. In this paper, we employ a more general utility function than Mankiw's quadratic one. Further, the disturbance and depreciation rate are respecified, respectively, as multiplicative and stochastic. The analytical consequence is a nonlinear ARMA(infinity,1) process, which implies that the linear ARMA(1,1) is a misspecificatio...

  11. Social Security and the Equity Premium Puzzle

    OpenAIRE

    Olovsson, Conny

    2004-01-01

    This paper shows that social security may be an important factor in explaining the equity premium puzzle. In the absence of shortselling constraints, the young shortsell bonds to the middle-aged and buy equity. Social security reduces the bond demand of the middle-aged, thereby restricting the possibilities of the young to finance their equity purchases. Their equity demand increases as does the average return to equity. Social security also increases the covariance between future consumption...

  12. The Ay puzzle and the nuclear force

    International Nuclear Information System (INIS)

    Hueber, D.

    1999-01-01

    The nucleon-deuteron analyzing power A y in elastic nucleon-deuteron scattering poses a longstanding puzzle. At energies E lab below approximately 30 MeV, A y cannot be described by any realistic NN force. The inclusion of existing three-nucleon forces does not improve the situation. Because of recent questions about the 3 P J NN phases, we examine whether reasonable changes in the NN force can resolve the puzzle. In order to do this, we investigate the effect on the 3 P J waves produced by changes in different parts of the potential (viz., the central force, tensor force, etc.), as well as on the 2-body observables and on A y . We find that it is not possible with reasonable changes in the NN potential to increase the 3-body A y , and at the same time to keep the 2-body observables unchanged. We therefore conclude that the A y puzzle is likely to be solved by new three-nucleon forces, such as those of spin-orbit type, which have not yet been taken into account. Refs. 7, tab. 1 (author)

  13. Dissolving the Puzzle of Resultant Moral Luck.

    Science.gov (United States)

    Levy, Neil

    The puzzle of resultant moral luck arises when we are disposed to think that an agent who caused a harm deserves to be blamed more than an otherwise identical agent who did not. One popular (but controversial) perspective on resultant moral luck explains our dispositions to produce different judgments with regard to the agents who feature in these cases as a product not of what they genuinely deserve but of our epistemic situation. On this account, there is no genuine resultant moral luck; there is only luck in what evidence becomes available to observers. In this paper, I develop an evolutionary account of our inclination to take the results of actions as evidence for the mental states of agents, thereby explaining why the resulting intuitions are recalcitrant to correction. The account explains why the puzzle of resultant moral luck arises: because our disposition to take the harms agents cause as evidence of their mental states can produce intuitions which conflict with those that arise when we examine agents' mental states without reference to the results of their actions. The account also helps to solve the puzzle of resultant moral luck, by providing a strong reason to ignore the intuitions caused by our disposition to regard actual harms as evidence of mental states. Since these intuitions arise using an unreliable proxy for agents' mental states, they ought to be trumped by more reliable evidence.

  14. The Ay puzzle and the nuclear force

    International Nuclear Information System (INIS)

    Hueber, D.; Friar, J.L.

    1998-01-01

    The nucleon-deuteron analyzing power A y in elastic nucleon-deuteron scattering poses a longstanding puzzle. At energies E lab below approximately 30 MeV A y cannot be described by any realistic nucleon-nucleon (NN) force. The inclusion of existing three-nucleon forces does not improve the situation. Because of recent questions about the 3 P J NN phases, we examine whether reasonable changes in the NN force can resolve the puzzle. In order to do this we investigate the effect on the 3 P J waves produced by changes in different parts of the potential (viz., the central force, tensor force, etc.), as well as on the two-body observables and on A y . We find that it is not possible with reasonable changes in the NN potential to increase the three-body A y and at the same time to keep the two-body observables unchanged. We therefore conclude that the A y puzzle is likely to be solved by new three-nucleon forces, such as those of the spin-orbit type, which have not yet been taken into account. copyright 1998 The American Physical Society

  15. Early puzzle play: a predictor of preschoolers' spatial transformation skill.

    Science.gov (United States)

    Levine, Susan C; Ratliff, Kristin R; Huttenlocher, Janellen; Cannon, Joanna

    2012-03-01

    Individual differences in spatial skill emerge prior to kindergarten entry. However, little is known about the early experiences that may contribute to these differences. The current study examined the relation between children's early puzzle play and their spatial skill. Children and parents (n = 53) were observed at home for 90 min every 4 months (6 times) between 2 and 4 years of age (26 to 46 months). When children were 4 years 6 months old, they completed a spatial task involving mental transformations of 2-dimensional shapes. Children who were observed playing with puzzles performed better on this task than those who did not, controlling for parent education, income, and overall parent word types. Moreover, among those children who played with puzzles, frequency of puzzle play predicted performance on the spatial transformation task. Although the frequency of puzzle play did not differ for boys and girls, the quality of puzzle play (a composite of puzzle difficulty, parent engagement, and parent spatial language) was higher for boys than for girls. In addition, variation in puzzle play quality predicted performance on the spatial transformation task for girls but not for boys. Implications of these findings as well as future directions for research on the role of puzzle play in the development of spatial skill are discussed. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  16. Early Puzzle Play: A predictor of preschoolers’ spatial transformation skill

    Science.gov (United States)

    Levine, S.C.; Ratliff, K.R.; Huttenlocher, J.; Cannon, J.

    2011-01-01

    Individual differences in spatial skill emerge prior to kindergarten entry. However, little is known about the early experiences that may contribute to these differences. The current study examines the relation between children’s early puzzle play and their spatial skill. Children and parents (n = 53) were observed at home for 90 minutes every four months (six times) between 2 and 4 years of age (26 to 46 months). When children were 4 years 6 months old, they completed a spatial task involving mental transformations of 2D shapes. Children who were observed playing with puzzles performed better on this task than those who did not, controlling for parent education, income, and overall parent word types. Moreover, among those children who played with puzzles, frequency of puzzle play predicted performance on the spatial transformation task. Although the frequency of puzzle play did not differ for boys and girls, the quality of puzzle play (a composite of puzzle difficulty, parent engagement, and parent spatial language) was higher for boys than girls. In addition, variation in puzzle play quality predicted performance on the spatial transformation task for girls but not boys. Implications of these findings as well as future directions for research on the role of the role of puzzle play in the development of spatial skill are discussed. PMID:22040312

  17. Nuclear clustering and the electron screening puzzle

    Science.gov (United States)

    Bertulani, C. A.; Spitaleri, C.

    2018-01-01

    Electron screening changes appreciably the magnitude of astrophysical nuclear reactions within stars. This effect is also observed in laboratory experiments on Earth, where atomic electrons are present in the nuclear targets. Theoretical models were developed over the past 30 years and experimental measurements have been carried out to study electron screening in thermonuclear reactions. None of the theoretical models were able to explain the high values of the experimentally determined screening potentials. We explore the possibility that the "electron screening puzzle" is due to nuclear clusterization and polarization e_ects in the fusion reactions. We will discuss the supporting arguments for this scenario.

  18. Nature's Greatest Puzzles

    Energy Technology Data Exchange (ETDEWEB)

    Quigg, Chris; /Fermilab

    2005-02-01

    It is a pleasure to be part of the SLAC Summer Institute again, not simply because it is one of the great traditions in our field, but because this is a moment of great promise for particle physics. I look forward to exploring many opportunities with you over the course of our two weeks together. My first task in talking about Nature's Greatest Puzzles, the title of this year's Summer Institute, is to deconstruct the premise a little bit.

  19. Last piece of the puzzle for ATLAS

    CERN Multimedia

    Clare Ryan

    At around 15.40 on Friday 29th February the ATLAS collaboration cracked open the champagne as the second of the small wheels was lowered into the cavern. Each of ATLAS' small wheels are 9.3 metres in diameter and weigh 100 tonnes including the massive shielding elements. They are the final parts of ATLAS' muon spectrometer. The first piece of ATLAS was installed in 2003 and since then many detector elements have journeyed down the 100 metre shaft into the ATLAS underground cavern. This last piece completes this gigantic puzzle.

  20. Sampling Random Bioinformatics Puzzles using Adaptive Probability Distributions

    DEFF Research Database (Denmark)

    Have, Christian Theil; Appel, Emil Vincent; Bork-Jensen, Jette

    2016-01-01

    We present a probabilistic logic program to generate an educational puzzle that introduces the basic principles of next generation sequencing, gene finding and the translation of genes to proteins following the central dogma in biology. In the puzzle, a secret "protein word" must be found by asse...

  1. Decoding Codewords: Statistical Analysis of a Newspaper Puzzle

    Science.gov (United States)

    Meacock, Susan; Meacock, Geoff

    2012-01-01

    In recent years English newspapers have started featuring a number of puzzles other than the ubiquitous crossword. Many of the puzzles are of Japanese origin such as Sudoku, Kakuro or Hidato. However, one recent one is very English and is called variously Cross-code, Alphapuzzle or some other name. In this article, it will be known as Codeword.…

  2. A Puzzle Used to Teach the Cardiac Cycle

    Science.gov (United States)

    Marcondes, Fernanda K.; Moura, Maria J. C. S.; Sanches, Andrea; Costa, Rafaela; Oliveira de Lima, Patricia; Groppo, Francisco Carlos; Amaral, Maria E. C.; Zeni, Paula; Gaviao, Kelly Cristina; Montrezor, Luís H.

    2015-01-01

    The aim of the present article is to describe a puzzle developed for use in teaching cardiac physiology classes. The puzzle presents figures of phases of the cardiac cycle and a table with five columns: phases of cardiac cycle, atrial state, ventricular state, state of atrioventricular valves, and pulmonary and aortic valves. Chips are provided…

  3. The Clock Is Ticking: Library Orientation as Puzzle Room

    Science.gov (United States)

    Reade, Tripp

    2017-01-01

    Tripp Reade is the school librarian at Cardinal Gibbons High School in Raleigh, North Carolina. This article describes how he redesigned his school's library orientation program after learning about escape rooms and a variant known as puzzle rooms. Puzzle rooms present players with a set of challenges to solve; they require "teamwork,…

  4. Crossword Puzzles as Learning Tools in Introductory Soil Science

    Science.gov (United States)

    Barbarick, K. A.

    2010-01-01

    Students in introductory courses generally respond favorably to novel approaches to learning. To this end, I developed and used three crossword puzzles in spring and fall 2009 semesters in Introductory Soil Science Laboratory at Colorado State University. The first hypothesis was that crossword puzzles would improve introductory soil science…

  5. The Puzzle of Visual Development: Behavior and Neural Limits.

    Science.gov (United States)

    Kiorpes, Lynne

    2016-11-09

    The development of visual function takes place over many months or years in primate infants. Visual sensitivity is very poor near birth and improves over different times courses for different visual functions. The neural mechanisms that underlie these processes are not well understood despite many decades of research. The puzzle arises because research into the factors that limit visual function in infants has found surprisingly mature neural organization and adult-like receptive field properties in very young infants. The high degree of visual plasticity that has been documented during the sensitive period in young children and animals leaves the brain vulnerable to abnormal visual experience. Abnormal visual experience during the sensitive period can lead to amblyopia, a developmental disorder of vision affecting ∼3% of children. This review provides a historical perspective on research into visual development and the disorder amblyopia. The mismatch between the status of the primary visual cortex and visual behavior, both during visual development and in amblyopia, is discussed, and several potential resolutions are considered. It seems likely that extrastriate visual areas further along the visual pathways may set important limits on visual function and show greater vulnerability to abnormal visual experience. Analyses based on multiunit, population activity may provide useful representations of the information being fed forward from primary visual cortex to extrastriate processing areas and to the motor output. Copyright © 2016 the authors 0270-6474/16/3611384-10$15.00/0.

  6. Jigsaw Puzzles As Cognitive Enrichment (PACE) - the effect of solving jigsaw puzzles on global visuospatial cognition in adults 50 years of age and older: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Fissler, Patrick; Küster, Olivia C; Loy, Laura S; Laptinskaya, Daria; Rosenfelder, Martin J; von Arnim, Christine A F; Kolassa, Iris-Tatjana

    2017-09-06

    Neurocognitive disorders are an important societal challenge and the need for early prevention is increasingly recognized. Meta-analyses show beneficial effects of cognitive activities on cognition. However, high financial costs, low intrinsic motivation, logistic challenges of group-based activities, or the need to operate digital devices prevent their widespread application in clinical practice. Solving jigsaw puzzles is a cognitive activity without these hindering characteristics, but cognitive effects have not been investigated yet. With this study, we aim to evaluate the effect of solving jigsaw puzzles on visuospatial cognition, daily functioning, and psychological outcomes. The pre-posttest, assessor-blinded study will include 100 cognitively healthy adults 50 years of age or older, who will be randomly assigned to a jigsaw puzzle group or a cognitive health counseling group. Within the 5-week intervention period, participants in the jigsaw puzzle group will engage in 30 days of solving jigsaw puzzles for at least 1 h per day and additionally receive cognitive health counseling. The cognitive health counseling group will receive the same counseling intervention but no jigsaw puzzles. The primary outcome, global visuospatial cognition, will depict the average of the z-standardized performance scores in visuospatial tests of perception, constructional praxis, mental rotation, processing speed, flexibility, working memory, reasoning, and episodic memory. As secondary outcomes, we will assess the eight cognitive abilities, objective and subjective visuospatial daily functioning, psychological well-being, general self-efficacy, and perceived stress. The primary data analysis will be based on mixed-effects models in an intention-to-treat approach. Solving jigsaw puzzles is a low-cost, intrinsically motivating, cognitive leisure activity, which can be executed alone or with others and without the need to operate a digital device. In the case of positive results

  7. Matter-antimatter puzzle: LHCb improves resolution

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In 2010, Fermilab’s DØ experiment reported a one percent difference in the properties of matter and antimatter in decays of B mesons (that is, particles containing beauty quarks) to muons. Saturday, at the ICHEP Conference in Melbourne, the LHCb experiment at CERN presents new results, which do not confirm this anomaly and are consistent with the Standard Model predictions. The same experiment has also presented the first evidence of asymmetry arising in other decays of the same family of mesons. The image becomes clearer but the puzzle has not yet been solved.   Inside the LHCb detector. The matter-antimatter imbalance in the Universe is a very hot topic in physics. The conundrum arises from the fact that, although objects made of antimatter are not observed in the Universe, theory predicts that matter and antimatter be created equally in particle interactions and in the Big Bang. Only small deviations from this very symmetric behaviour are incorporated in the theory. E...

  8. A new piece of the puzzle

    CERN Multimedia

    2005-01-01

    The team responsible for the installation of the hadronic calorimeter's central barrel after completion of the assembly work. Assembly of the great ATLAS puzzle continues underground. On 10 December, the final module of the central barrel of the tile hadronic calorimeter was assembled. This piece of the tile calorimeter had already been assembled above ground during a "dress rehearsal" in 2003 (see Bulletin no 46/2003, 10 November 2003). The hadronic calorimeter's two other barrels, the so-called "extended barrels", remain to be assembled with this first central barrel, which now surrounds the electromagnetic calorimeter barrel that was lowered into the cavern at the end of October. At the end of November, the second of the eight barrel toroid coils was also installed.

  9. Heavy quarkonium: progress, puzzles, and opportunities

    CERN Document Server

    Brambilla, N; Heltsley, B K; Vogt, R; Bodwin, G T; Eichten, E; Frawley, A D; Meyer, A B; Mitchell, R E; Papadimitriou, V; Petreczky, P; Petrov, A A; Robbe, P; Vairo, A; Andronic, A; Arnaldi, R; Artoisenet, P; Bali, G; Bertolin, A; Bettoni, D; Brodzicka, J; Bruno, G E; Caldwell, A; Catmore, J; Chang, C H; Chao, K T; Chudakov, E; Cortese, P; Crochet, P; Drutskoy, A; Ellwanger, U; Faccioli, P; Gabareen Mokhtar, A; Garcia i Tormo, X; Hanhart, C; Harris, F A; Kaplan, D M; Klein, S R; Kowalski, H; Lansberg, J P; Levichev, E; Lombardo, V; Lourenco, C; Maltoni, F; Mocsy, A; Mussa, R; Navarra, F S; Negrini, M; Nielsen, M; Olsen, S L; Pakhlov, P; Pakhlova, G; Peters, K; Polosa, A D; Qian, W; Qiu, J W; Rong, G; Sanchis-Lozano, M A; Scomparin, E; Senger, P; Simon, F; Stracka, S; Sumino, Y; Voloshin, M; Weiss, C; Wohri, H K; Yuan, C Z

    2011-01-01

    A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA, JLab, and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing ...

  10. The Eco-Efficiency Premium Puzzle

    International Nuclear Information System (INIS)

    Guenster, N.; Derwall, J.; Bauer, R.; Koedijk, K.

    2004-09-01

    Conventional investment theory suggests that socially responsible investing (SRI) leads to inferior, rather than superior, portfolio performance. Using Innovest's well-established corporate eco-efficiency scores, we provide evidence supporting the contrary. We compose two equity portfolios that differ in ecoefficiency characteristics and find that our high-ranked portfolio provided substantially higher average returns compared to its low-ranked counterpart over the period 1995-2003. Using a wide range of performance attribution techniques to address common methodological concerns, we show that this performance differential cannot be explained by differences in market sensitivity, investment style, or industry-specific components. We finally investigate whether this ecoefficiency premium puzzle withstands the inclusion of transaction costs scenarios, and evaluate how excess returns can be earned in a practical setting via a best-in-class stock selection strategy. The results remain significant under all levels of transactions costs, thus suggesting that the incremental benefits of SRI can be substantial

  11. SOLVING THE PUZZLE OF SUBHALO SPINS

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yang; Lin, Weipeng [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Shanghai 200030 (China); Pearce, Frazer R.; Lux, Hanni; Onions, Julian [School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD (United Kingdom); Muldrew, Stuart I., E-mail: wangyang@shao.ac.cn, E-mail: linwp@shao.ac.cn [Department of Physics and Astronomy, University of Leicester, University Road, Leicester, LE1 7RH (United Kingdom)

    2015-03-10

    Investigating the spin parameter distribution of subhalos in two high-resolution isolated halo simulations, recent work by Onions et al. suggested that typical subhalo spins are consistently lower than the spin distribution found for field halos. To further examine this puzzle, we have analyzed simulations of a cosmological volume with sufficient resolution to resolve a significant subhalo population. We confirm the result of Onions et al. and show that the typical spin of a subhalo decreases with decreasing mass and increasing proximity to the host halo center. We interpret this as the growing influence of tidal stripping in removing the outer layers, and hence the higher angular momentum particles, of the subhalos as they move within the host potential. Investigating the redshift dependence of this effect, we find that the typical subhalo spin is smaller with decreasing redshift. This indicates a temporal evolution, as expected in the tidal stripping scenario.

  12. Solar Twins and the Barium Puzzle

    International Nuclear Information System (INIS)

    Reddy, Arumalla B. S.; Lambert, David L.

    2017-01-01

    Several abundance analyses of Galactic open clusters (OCs) have shown a tendency for Ba but not for other heavy elements (La−Sm) to increase sharply with decreasing age such that Ba was claimed to reach [Ba/Fe] ≃ +0.6 in the youngest clusters (ages < 100 Myr) rising from [Ba/Fe] = 0.00 dex in solar-age clusters. Within the formulation of the s -process, the difficulty to replicate higher Ba abundance and normal La−Sm abundances in young clusters is known as the barium puzzle. Here, we investigate the barium puzzle using extremely high-resolution and high signal-to-noise spectra of 24 solar twins and measured the heavy elements Ba, La, Ce, Nd, and Sm with a precision of 0.03 dex. We demonstrate that the enhanced Ba ii relative to La−Sm seen among solar twins, stellar associations, and OCs at young ages (<100 Myr) is unrelated to aspects of stellar nucleosynthesis but has resulted from overestimation of Ba by standard methods of LTE abundance analysis in which the microturbulence derived from the Fe lines formed deep in the photosphere is insufficient to represent the true line broadening imposed on Ba ii lines by the upper photospheric layers from where the Ba ii lines emerge. Because the young stars have relatively active photospheres, Ba overabundances most likely result from the adoption of a too low value of microturbulence in the spectrum synthesis of the strong Ba ii lines but the change of microturbulence in the upper photosphere has only a minor affect on La−Sm abundances measured from the weak lines.

  13. Exfoliation syndrome: assembling the puzzle pieces.

    Science.gov (United States)

    Pasquale, Louis R; Borrás, Terete; Fingert, John H; Wiggs, Janey L; Ritch, Robert

    2016-09-01

    To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19-20, 2014. The highlights of three categories of talks on cutting edge research in the field were summarized. Exfoliation syndrome (XFS) is a systemic disorder with a substantial ocular burden, including high rates of cataract, cataract surgery complications, glaucoma and retinal vein occlusion. New information about XFS is akin to puzzle pieces that do not quite join together to reveal a clear picture regarding how exfoliation material (XFM) forms. Meeting participants concluded that it is unclear how the mild homocysteinemia seen in XFS might contribute to the disarrayed extracellular aggregates characteristic of this syndrome. Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear. Variants in a new genomic region, CACNA1A associated with XFS, may alter calcium concentrations at the cell surface and facilitate XFM formation but much more work is needed before we can place this new finding in proper context. It is hoped that various animal model and ex vivo systems will emerge that will allow for proper assembly of the puzzle pieces into a coherent picture of XFS pathogenesis. A clear understanding of XFS pathogenesis may lead to 'upstream solutions' to reduce the ocular morbidity produced by XFS. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  14. Solar Twins and the Barium Puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Arumalla B. S.; Lambert, David L., E-mail: bala@astro.as.utexas.edu [W.J. McDonald Observatory and Department of Astronomy, The University of Texas at Austin, Austin, TX 78712-1205 (United States)

    2017-08-20

    Several abundance analyses of Galactic open clusters (OCs) have shown a tendency for Ba but not for other heavy elements (La−Sm) to increase sharply with decreasing age such that Ba was claimed to reach [Ba/Fe] ≃ +0.6 in the youngest clusters (ages < 100 Myr) rising from [Ba/Fe] = 0.00 dex in solar-age clusters. Within the formulation of the s -process, the difficulty to replicate higher Ba abundance and normal La−Sm abundances in young clusters is known as the barium puzzle. Here, we investigate the barium puzzle using extremely high-resolution and high signal-to-noise spectra of 24 solar twins and measured the heavy elements Ba, La, Ce, Nd, and Sm with a precision of 0.03 dex. We demonstrate that the enhanced Ba ii relative to La−Sm seen among solar twins, stellar associations, and OCs at young ages (<100 Myr) is unrelated to aspects of stellar nucleosynthesis but has resulted from overestimation of Ba by standard methods of LTE abundance analysis in which the microturbulence derived from the Fe lines formed deep in the photosphere is insufficient to represent the true line broadening imposed on Ba ii lines by the upper photospheric layers from where the Ba ii lines emerge. Because the young stars have relatively active photospheres, Ba overabundances most likely result from the adoption of a too low value of microturbulence in the spectrum synthesis of the strong Ba ii lines but the change of microturbulence in the upper photosphere has only a minor affect on La−Sm abundances measured from the weak lines.

  15. A Resolution of the Purchasing Power Parity Puzzle

    DEFF Research Database (Denmark)

    Frydman, Roman; Goldberg, Michael D.; Johansen, Søren

    Asset prices undergo long swings that revolve around benchmark levels. In currency markets, fluctuations involve real exchange rates that are highly persistent and that move in near-parallel fashion with nominal rates. The inability to explain these two regularities with one model has been called...... the "Purchasing Power Parity puzzle". In this paper, we trace the puzzle to exchange rate modelers' use of the "Rational Expectations Hypothesis". We show that once imperfect knowledge is recognized, a monetary model is able to account for the puzzle, as well as other salient features of the data, including...

  16. Real exchange rate persistence and the excess return puzzle

    DEFF Research Database (Denmark)

    Juselius, Katarina; Assenmacher, Katrin

    2017-01-01

    The PPP puzzle refers to the wide swings of nominal exchange rates around their long-run equilibrium values whereas the excess return puzzle represents the persistent deviation of the domestic-foreign interest rate differential from the expected change in the nominal exchange rate. Using the I(2......) cointegrated VAR model, much of the excess return puzzle disappears when an uncertainty premium in the foreign exchange market, proxied by the persistent PPP gap, is introduced. Self-reinforcing feedback mechanisms seem to cause the persistence in the Swiss-US parity conditions. These results support imperfect...

  17. Teaching the Blue-Eyed Islanders Puzzle in a Liberal Arts Mathematics Course

    Science.gov (United States)

    Shea, Stephen

    2012-01-01

    The blue-eyed islanders puzzle is an old and challenging logic puzzle. This is a narrative of an experience introducing a variation of this puzzle on the first day of classes in a liberal arts mathematics course for non-majors. I describe an exercise that was used to facilitate the class's understanding of the puzzle.

  18. Puzzling through General Chemistry: A Light-Hearted Approach to Engaging Students with Chemistry Content

    Science.gov (United States)

    Boyd, Susan L.

    2007-01-01

    Several puzzles are designed to be used by chemistry students as learning tools and teach them basic chemical concepts. The topics of the puzzles are based on the chapters from Chemistry, The Central Science used in general chemistry course and the puzzles are in various forms like crosswords, word searches, number searches, puzzles based on…

  19. Formative Assessment Probes: Mountaintop Fossil: A Puzzling Phenomenon

    Science.gov (United States)

    Keeley, Page

    2015-01-01

    This column focuses on promoting learning through assessment. This month's issue describes using formative assessment probes to uncover several ways of thinking about the puzzling discovery of a marine fossil on top of a mountain.

  20. Stateless Puzzles for Real Time Online Fraud Preemption

    OpenAIRE

    Rahman, Mizanur; Recabarren, Ruben; Carbunar, Bogdan; Lee, Dongwon

    2017-01-01

    The profitability of fraud in online systems such as app markets and social networks marks the failure of existing defense mechanisms. In this paper, we propose FraudSys, a real-time fraud preemption approach that imposes Bitcoin-inspired computational puzzles on the devices that post online system activities, such as reviews and likes. We introduce and leverage several novel concepts that include (i) stateless, verifiable computational puzzles, that impose minimal performance overhead, but e...

  1. The Puzzle of the Scandinavian Welfare State and Social Trust

    DEFF Research Database (Denmark)

    Svendsen, Gunnar Lind Haase; Svendsen, Gert Tinggaard

    2015-01-01

    The Scandinavian welfare model is a puzzle to economists: It works economically, even though free-riding should prevail with its explosive cocktail of high taxation and high social benefits. One overlooked solution to the puzzle could be the unique stock of social trust present in Scandinavia. Here......, the four Scandinavian countries (Norway, Denmark, Sweden, and Finland) form the top three with scores above 60 percent social trust on a ranking that covers 94 countries from all over the world....

  2. CROSSWORD PUZZLE INCREASE ATTENTION OF CHILDREN WITH ADHD

    Directory of Open Access Journals (Sweden)

    Ah. Yusuf

    2017-07-01

    Full Text Available Introduction: Attention deficit is one of three main problems of children with Attention Deficit Hyperactivity Disorder (ADHD. Children experience difficulty of paying attention and concentrating to one or more things or objects. As a results these children cannot perform the task well. Crossword puzzle is one of games that may increase attention and concentration. The aim of this study was to analyze the effect of crossword puzzle to increase attention of children with ADHD. Method: Pre-experimental design was employed in this study. The population was ADHD students in Cakra Autisme Therapy. Seven students were recruited by means of purposive sampling. The independent variable was crossword puzzle and the dependent variable was the increase of attention. Data were collected using observation sheet and analyzed using Wilcoxon Signed Rank Test with level of significance of α≤ 0.05. Result: Result showed that crossword puzzle could increase attention. Respondent’s attention improved from less to good attention, particularly in playing activities (p=0.014. Analysis: This finding suggests that there was differences of attention between pre and post-test. It can be concluded that crossword puzzle can increase attention of the students with ADHD. Discussion: It is recommended for teachers and parents of ADHD children to give them crossword puzzle game everyday at school or at home. Further studies should involve larger sample size and employs another game not only to increase attention, but also reduce hyperactivity and impulsivity of ADHD child.

  3. LEARNING VOCABULARY THROUGH COLOURFUL PUZZLE GAME

    Directory of Open Access Journals (Sweden)

    Risca Dwiaryanti

    2014-05-01

    Full Text Available Vocabulary plays an important role because it links to the four skills of listening, speaking, reading, and writing. Those aspects should be integrated in teaching and learning process of English. However, the students must be able to know the meaning of each word or vocabulary of English in order to master the four skills. It is as a mean to create a sentence in daily communication to show someone’s feeling, opinion, idea, desire, etc. So that, both speakers understand what the other speaker mean. However, English as a second language in Indonesia seems very hard for the students to master vocabulary of English. It makes them not easy to be understood directly and speak fluently. The students, sometimes, get difficulties in understanding, memorizing the meaning of the vocabulary, and getting confused in using the new words. There must be an effective strategy to attract students’ interest, break the boredom, and make the class more lively. Based on the writer experience, Colourful Puzzle Game is able to make the students learn vocabulary quickly. It needs teacher’s creativity to create the materials of this game based on the class condition. The teacher just need a game board made from colourful papers, write any command and prohibition words on it. A dice is a tool to decide where the player should stop based on the number. Some pins as counter as sign of each player.

  4. Heavy quarkonium: progress, puzzles, and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Brambilla, N; Heltsley, B K; Vogt, R; Bodwin, G T; Eichten, E; Frawley, A D; Meyer, A B; Mitchell, R E; Papdimitriou, V; Petreczky, P; Petrov, A A; Robbe, P; Vairo, A; Andronic, A; Arnaldi, R; Artoisenet, P; Bali, G; Bertolin, A; Bettoni, D; Brodzicka, J; Bruno, G E; Caldwell, A; Catmore, J; Chang, C -H; Chao, K -T; Chudakov, E; Cortese, P; Crochet, P; Drutskoy, A; Ellwanger, U; Faccioli, P; Gabareen Mokhtar, A; Garcia i Tormo, X; Hanhart, C; Harris, F A; Kaplan, D M; Klein, S R; Kowalski, H; Lansberg, J -P; Levichev, E; Lombardo, V; Loureno, C; Maltoni, F; Mocsy, A; Mussa, R; Navarra, F S; Negrini, M; Nielsen, M; Olsen, S L; Pakhlov, P; Pakhlova, G; Peters, K; Polosa, A D; Qian, W; Qiu, J -W; Rong, G; Sanchis-Lozano, M A; Scomparin, E; Senger, P; Simon, F; Stracka, S; Sumino, Y; Voloshin, M; Weiss, C; Wohri, H K; Yuan, C -Z

    2011-02-01

    A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA, JLab, and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\\bar{c}, b\\bar{b}, and b\\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.

  5. Evaluation of the three-nucleon analyzing power puzzle

    International Nuclear Information System (INIS)

    Tornow, W.; Witala, H.

    1998-01-01

    The current status of the three-nucleon analyzing power puzzle is reviewed. Applying tight constraints on the allowed deviations between calculated predictions and accepted values for relevant nucleon-nucleon observables reveals that energy independent correction factors applied to the 3 P j nucleon-nucleon interactions can not solve the puzzle. Furthermore, using the same constraints, charge-independence breaking in the 3 P j nucleon-nucleon interactions can be ruled out as a possible tool to improve the agreement between three-nucleon calculations and data. The study of the energy dependence of the three-nucleon analyzing power puzzle gives clear evidence that the 3 P j nucleon-nucleon interaction obtained from phase-shift analyses and used in potential models are correct above about 25 MeV, i.e., the 3 P j nucleon-nucleon interactions have to be modified only at lower energies in order to solve the three-nucleon analyzing power puzzle, unless new three-nucleon forces can be found that account for the three-nucleon analyzing power puzzle without destroying the beautiful agreement between rigorous three-nucleon calculations and a large body of accurate three-nucleon data. (orig.)

  6. Three Modes of Hydrogeophysical Investigation: Puzzles, Mysteries, and Conundrums

    Science.gov (United States)

    Ferre, P. A.

    2011-12-01

    In an article in the New Yorker in 2007, Malcolm Gladwell discussed the distinction that national security expert Gregory Treverton has made between puzzles and mysteries. Specifically, puzzles are problems that we understand and that will eventually be solved when we amass enough information. (Think crossword puzzles.) Mysteries are problems for which we have the necessary information, but it is often overwhelmed by irrelevant or misleading input. To solve a mystery, we require improved analysis. (Think find-a-word.) Gladwell goes on to explain that, in the national security realm, the Cold War was a puzzle while the current national security condition is a mystery. I will discuss the past, current, and future trajectories of hydrogeophysics in terms of puzzles and mysteries. I will also add a third class of problem: conundrums - those for which we lack sufficient information about their structure to know how to solve them. A conundrum is a mystery with an unexpected twist. I hope to make the case that the future growth of hydrogeophysics lies in our ability to address this more challenging and more interesting class of problem.

  7. Evaluation of the three-nucleon analyzing power puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Tornow, W. [Duke Univ., Durham, NC (United States). Dept. of Physics]|[Triangle Univ. Nuclear Lab., Durham, NC (United States); Witala, H. [Uniwersytet Jagiellonski, Cracow (Poland). Inst. Fizyki

    1998-07-20

    The current status of the three-nucleon analyzing power puzzle is reviewed. Applying tight constraints on the allowed deviations between calculated predictions and accepted values for relevant nucleon-nucleon observables reveals that energy independent correction factors applied to the {sup 3}P{sub j} nucleon-nucleon interactions can not solve the puzzle. Furthermore, using the same constraints, charge-independence breaking in the {sup 3}P{sub j} nucleon-nucleon interactions can be ruled out as a possible tool to improve the agreement between three-nucleon calculations and data. The study of the energy dependence of the three-nucleon analyzing power puzzle gives clear evidence that the {sup 3}P{sub j} nucleon-nucleon interaction obtained from phase-shift analyses and used in potential models are correct above about 25 MeV, i.e., the {sup 3}P{sub j} nucleon-nucleon interactions have to be modified only at lower energies in order to solve the three-nucleon analyzing power puzzle, unless new three-nucleon forces can be found that account for the three-nucleon analyzing power puzzle without destroying the beautiful agreement between rigorous three-nucleon calculations and a large body of accurate three-nucleon data. (orig.) 18 refs.

  8. On puzzles and non-puzzles in B→ππ,πK decays

    International Nuclear Information System (INIS)

    Fleischer, R.; Recksiegel, S.; Schwab, F.

    2007-01-01

    Recently, we have seen interesting progress in the exploration of CP violation in B d 0 →π + π - : the measurements of mixing-induced CP violation by the BaBar and Belle collaborations are now in good agreement with each other, whereas the picture of direct CP violation is still unclear. Using the branching ratio and direct CP asymmetry of B d 0 →π - K + , this situation can be clarified. We predict A CP dir (B d →π + π - )=-0.24±0.04, which favours the BaBar result, and we extract γ=(70.0 -4.3 +3.8 ) , which agrees with the unitarity triangle fits. Extending our analysis to other B→πK modes and B s 0 →K + K - with the help of the SU(3) flavour symmetry and plausible dynamical assumptions, we find that all observables with colour-suppressed electroweak penguin contributions are measured to be in excellent agreement with the standard model. As far as the ratios R c,n of the charged and neutral B→πK branching ratios are concerned, which are sizeably affected by electroweak penguin contributions, our standard-model predictions have almost unchanged central values but significantly reduced errors. Since the new data have moved quite a bit towards these results, the ''B→πK puzzle'' for the CP conserving quantities has been significantly reduced. However, the mixing-induced CP violation of B d 0 →π 0 K S does look puzzling; if confirmed by future measurements, this effect could be accommodated through a modified electroweak penguin sector with a large CP violating new-physics phase. Finally, we point out that the established difference between the direct CP asymmetries of B ± →π 0 K ± and B d →π -+ K ± appears to be generated by hadronic and not by new physics. (orig.)

  9. Distress risk and leverage puzzles: Evidence from Taiwan

    Directory of Open Access Journals (Sweden)

    Kung-Cheng Ho

    2016-05-01

    Full Text Available Financial distress has been invoked in the asset pricing literature to explain the anomalous patterns in the cross-section of stock returns. The risk of financial distress can be measured using indexes. George and Hwang (2010 suggest that leverage can explain the distress risk puzzle and that firms with high costs choose low leverage to reduce distress intensities and earn high returns. This study investigates whether this relationship exists in the Taiwan market. When examined separately, distress intensity is found to be negatively related to stock returns, but leverage is found to not be significantly related to stock returns. The results are the same when distress intensity and leverage are examined simultaneously. After assessing the robustness by using O-scores, distress risk puzzle is found to exist in the Taiwan market, but the leverage puzzle is not

  10. International trade network: fractal properties and globalization puzzle.

    Science.gov (United States)

    Karpiarz, Mariusz; Fronczak, Piotr; Fronczak, Agata

    2014-12-12

    Globalization is one of the central concepts of our age. The common perception of the process is that, due to declining communication and transport costs, distance becomes less and less important. However, the distance coefficient in the gravity model of trade, which grows in time, indicates that the role of distance increases rather than decreases. This, in essence, captures the notion of the globalization puzzle. Here, we show that the fractality of the international trade system (ITS) provides a simple solution for the puzzle. We argue that the distance coefficient corresponds to the fractal dimension of ITS. We provide two independent methods, the box counting method and spatial choice model, which confirm this statement. Our results allow us to conclude that the previous approaches to solving the puzzle misinterpreted the meaning of the distance coefficient in the gravity model of trade.

  11. The B→πK puzzle and supersymmetry

    International Nuclear Information System (INIS)

    Imbeault, Maxime; Baek, Seungwon; London, David

    2008-01-01

    At present, there are discrepancies between the measurements of several observables in B→πK decays and the predictions of the Standard Model (the 'B→πK puzzle'). Although the effect is not yet statistically significant-it is at the level of ≥3σ-it does hint at the presence of new physics. In this Letter, we explore whether supersymmetry (SUSY) can explain the B→πK puzzle. In particular, we consider the SUSY model of Grossman, Neubert and Kagan (GNK). We find that it is extremely unlikely that GNK explains the B→πK data. We also find a similar conclusion in many other models of SUSY. And there are serious criticisms of the two SUSY models that do reproduce the B→πK data. If the B→πK puzzle remains, it could pose a problem for SUSY models

  12. THE EQUITY PREMIUM PUZZLE AND EMOTIONAL ASSET PRICING

    OpenAIRE

    MARC GÜRTLER; NORA HARTMANN

    2007-01-01

    "Since the equity premium as well as the risk-free rate puzzle question the concepts central to financial and economic modeling, we apply behavioral decision theory to asset pricing in view of solving these puzzles. U.S. stock market data for the period 1960-2003 and German stock market data for the period 1977-2003 show that emotional investors who act in accordance to Bell's (1985) disappointment theory -a special case of prospect theory- and additionally administer mental accounts demand a...

  13. An overview of heavy quark energy loss puzzle at RHIC

    International Nuclear Information System (INIS)

    Djordjevic, Magdalena

    2006-01-01

    We give a theoretical overview of the heavy quark tomography puzzle posed by recent non-photonic single electron data from central Au+Au collisions at √s = 200A GeV. We show that radiative energy loss mechanisms alone are not able to explain large single electron suppression data, as long as realistic parameter values are assumed. We argue that a combined collisional and radiative pQCD approach can solve a substantial part of the non-photonic single electron puzzle

  14. The Meissner effect puzzle and the quantum force in superconductor

    International Nuclear Information System (INIS)

    Nikulov, A.V.

    2012-01-01

    The puzzle of the acceleration of the mobile charge carriers and the ions in the superconductor in direction opposite to the electromagnetic force revealed formerly in the Meissner effect is considered in the case of the transition of a narrow ring from normal to superconducting state. It is elucidated that the azimuthal quantum force was deduced eleven years ago from the experimental evidence of this acceleration but it cannot solve this puzzle. This quantum force explains other paradoxical phenomena connected with reiterated switching of the ring between normal and superconducting states.

  15. The Closed-End Funds Puzzle: A Survey Review

    Directory of Open Access Journals (Sweden)

    Marta Charrón

    2009-09-01

    Full Text Available The main objective of this paper is to explore the most salient research aimed at explaining the closed-end fund puzzle from both the traditional and behavioral finance perspectives. It provides a better understanding of closed-end fund behavior and motivates further research of closed-end funds, market efficiency, asset pricing and the traditional and behavioral finance paradigms. So far, none of the possible explanations from either traditional finance or behavioral finance have been able to fully account for the occurrence of the puzzle. It continues to be an important issue in the long standing debate between traditional finance and behavioral finance.

  16. NICHD Research Networks Help Piece Together the Puzzle of Polycystic Ovary Syndrome

    Science.gov (United States)

    ... Print NICHD research networks help piece together the puzzle of polycystic ovary syndrome Many people think that ... more like putting together a thousand-piece jigsaw puzzle. Except that you can’t check the cover ...

  17. Freestyle multiple propeller flap reconstruction (jigsaw puzzle approach) for complicated back defects.

    Science.gov (United States)

    Park, Sung Woo; Oh, Tae Suk; Eom, Jin Sup; Sun, Yoon Chi; Suh, Hyun Suk; Hong, Joon Pio

    2015-05-01

    The reconstruction of the posterior trunk remains to be a challenge as defects can be extensive, with deep dead space, and fixation devices exposed. Our goal was to achieve a tension-free closure for complex defects on the posterior trunk. From August 2006 to May 2013, 18 cases were reconstructed with multiple flaps combining perforator(s) and local skin flaps. The reconstructions were performed using freestyle approach. Starting with propeller flap(s) in single or multilobed design and sequentially in conjunction with adjacent random pattern flaps such as fitting puzzle. All defects achieved tensionless primary closure. The final appearance resembled a jigsaw puzzle-like appearance. The average size of defect was 139.6 cm(2) (range, 36-345 cm(2)). A total of 26 perforator flaps were used in addition to 19 random pattern flaps for 18 cases. In all cases, a single perforator was used for each propeller flap. The defect and the donor site all achieved tension-free closure. The reconstruction was 100% successful without flap loss. One case of late infection was noted at 12 months after surgery. Using multiple lobe designed propeller flaps in conjunction with random pattern flaps in a freestyle approach, resembling putting a jigsaw puzzle together, we can achieve a tension-free closure by distributing the tension to multiple flaps, supplying sufficient volume to obliterate dead space, and have reliable vascularity as the flaps do not need to be oversized. This can be a viable approach to reconstruct extensive defects on the posterior trunk. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  18. Puzzles in modern biology. I. Male sterility, failure reveals design [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Steven A. Frank

    2016-09-01

    Full Text Available Many human males produce dysfunctional sperm. Various plants frequently abort pollen. Hybrid matings often produce sterile males. Widespread male sterility is puzzling. Natural selection prunes reproductive failure. Puzzling failure implies something that we do not understand about how organisms are designed. Solving the puzzle reveals the hidden processes of design.

  19. The Effect of Monetary Policy on Exchange Rates : How to Solve the Puzzles

    NARCIS (Netherlands)

    Kumah, F.Y.

    1996-01-01

    Recent empirical research on the effects of monetary policy shocks on exchange rate fluctuations have encountered the exchange rate puzzle and th e forward discount bias puzzle.The exchange rate puzzle is the tendency of the domestic currency (of non-US G-7 countries) to depreciate against the US

  20. Teaching Proofs and Algorithms in Discrete Mathematics with Online Visual Logic Puzzles

    Science.gov (United States)

    Cigas, John; Hsin, Wen-Jung

    2005-01-01

    Visual logic puzzles provide a fertile environment for teaching multiple topics in discrete mathematics. Many puzzles can be solved by the repeated application of a small, finite set of strategies. Explicitly reasoning from a strategy to a new puzzle state illustrates theorems, proofs, and logic principles. These provide valuable, concrete…

  1. Games and puzzles for English as a second language

    CERN Document Server

    Fremont, Victoria

    2011-01-01

    Students can hone their verbal and grammatical skills with this entertaining workbook. Search-a-words, crossword puzzles, anagrams, and other challenges build vocabulary and spelling skills. They also help students understand and identify idioms, irregular past tenses and participles, and other linguistic stumbling blocks. Perfect for individual study or as a course supplement.

  2. Towards a security model for computational puzzle schemes

    NARCIS (Netherlands)

    Tang, Qiang; Jeckmans, Arjan

    2011-01-01

    In the literature, computational puzzle schemes have been considered as a useful tool for a number of applications, such as constructing timed cryptography, fighting junk emails, and protecting critical infrastructure from denial-of-service attacks. However, there is a lack of a general security

  3. General intelligence is an emerging property, not an evolutionary puzzle.

    Science.gov (United States)

    Ramus, Franck

    2017-01-01

    Burkart et al. contend that general intelligence poses a major evolutionary puzzle. This assertion presupposes a reification of general intelligence - that is, assuming that it is one "thing" that must have been selected as such. However, viewing general intelligence as an emerging property of multiple cognitive abilities (each with their own selective advantage) requires no additional evolutionary explanation.

  4. Pedagogy Corner: The Architect's Puzzle

    Science.gov (United States)

    Lovitt, Charles

    2017-01-01

    Some years back, the author found the following problem in a spatial puzzle book: how many ways can you put four blocks together, face to face (with no vertical rotation symmetry)? He gave each student just four blocks and they collectively tried combinations to eventually agree on the answer of 15. He used to think it was a halfway decent task,…

  5. Asset pricing puzzles explained by incomplete Brownian equilibria

    DEFF Research Database (Denmark)

    Christensen, Peter Ove; Larsen, Kasper

    We examine a class of Brownian based models which produce tractable incomplete equilibria. The models are based on finitely many investors with heterogeneous exponential utilities over intermediate consumption who receive partially unspanned income. The investors can trade continuously on a finit...... markets. Consequently, our model can simultaneously help explaining the risk-free rate and equity premium puzzles....

  6. What do we learn from the ρ-π puzzle

    International Nuclear Information System (INIS)

    Li Xueqian

    2010-01-01

    The experimental observation indicates that the branching ratio of ψ' →ρπ is very small while the ρ-π channel is a main one in J/ψ decays. To understand the puzzle, various interpretations have been proposed. Meanwhile according to the hadronic helicity selection rule, this decay mode should be suppressed. Numerical calculations are needed to determine how it is suppressed.We calculate the branching ratios of J/ψ→ρπ and ππ in the framework of QCD. The results show that the branching ratios are proportional to [(m u +m d )/(M J/ψ )] 2 for the ρπ mode and [(m u -m d )/(m J/ψ )] 2 for the ππ mode which is isospin violated. The theoretical prediction of the ratio of J/ψ → ρπ is smaller than data, but not too small to invoke a completely new mechanism. Thus the puzzle is still standing even though we learn much knowledge towards the puzzle and this will help to finally interpret the puzzle and then gain a deeper insight to the heavy quarkonia. (author)

  7. Crossword Puzzles as a Learning Tool for Vocabulary Development

    Science.gov (United States)

    Orawiwatnakul, Wiwat

    2013-01-01

    Introduction: Since vocabulary is a key basis on which reading achievement depends, various vocabulary acquisition techniques have become pivotal. Among the many teaching approaches, traditional or otherwise, the use of crossword puzzles seems to offer potential and a solution for the problem of learning vocabulary. Method: This study was…

  8. Adding a Piece to the Leaf Epidermal Cell Shape Puzzle.

    Science.gov (United States)

    von Wangenheim, Daniel; Wells, Darren M; Bennett, Malcolm J

    2017-11-06

    The jigsaw puzzle-shaped pavement cells in the leaf epidermis collectively function as a load-bearing tissue that controls organ growth. In this issue of Developmental Cell, Majda et al. (2017) shed light on how the jigsaw shape can arise from localized variations in wall stiffness between adjacent epidermal cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Unraveling "Braid": Puzzle Games and Storytelling in the Imperative Mood

    Science.gov (United States)

    Arnott, Luke

    2012-01-01

    "Unraveling Braid" analyzes how unconventional, non-linear narrative fiction can help explain the ways in which video games signify. Specifically, this essay looks at the links between the semiotic features of Jonathan Blow's 2008 puzzle-platform video game Braid and similar elements in Georges Perec's 1978 novel "Life A User's Manual," as well as…

  10. The Potential of Crossword Puzzles in Aiding English Language Learners

    Science.gov (United States)

    Merkel, Warren

    2016-01-01

    In an academic environment, teachers utilize crossword puzzles to help students learn or remember terminology. Outside the classroom, typically in daily newspapers, crosswords aid in vocabulary development, used as a learning tool, a leisure activity, or both. However, both the content and the grid structure of the crosswords in these two…

  11. Experimental status of the E/ι puzzle

    International Nuclear Information System (INIS)

    Lanaro, A.

    1996-11-01

    Despite the prolonged experimental effort devoted to the spectroscopy of the E/ι mesons, and the intense theoretical debate around this subject, many puzzling issues still prevent from a full understanding of the true scenario. The advent of new and more precise experimental measurements motivates a review on this topic

  12. Puzzling with potential : dynamic testing of analogical reasoning in children

    NARCIS (Netherlands)

    Stevenson, Claire Elisabeth

    2012-01-01

    Assessment procedures are frequent in children's school careers; however, measuring potential for learning has remained a puzzle. Dynamic testing is a method to assess cognitive potential that includes training in the assessment process. The goal of this thesis project was to develop a new dynamic

  13. The magic circle and the puzzle piece

    OpenAIRE

    Juul, Jesper

    2008-01-01

    In a common description, to play a game is to step inside a concrete or metaphorical magic circle where special rules apply. In video game studies, this description has received an inordinate amount of criticism which the paper argues has two primary sources: 1. a misreading of the basic concept of the magic circle and 2. a somewhat rushed application of traditional theoretical concerns onto games. The paper argues that games studies must move beyond conventional criticisms of binary distinct...

  14. Meson spectroscopy experiment at KEK - E/iota puzzle

    International Nuclear Information System (INIS)

    Tsuru, Tsuneaki

    1985-01-01

    Physics interests at the KEK (National Laboratory for High Energy Physics) are (1) search for exotic mesons such as glueballs (gg), meiktons (q anti q g) and multiquark states (q sup(2 - )q 2 ), (2) search for missing ordinary mesons (q anti q) and confirmation of unestablished mesons, and (3) new informations of quark contents of mesons, mixing angles of SU(3) singlet-octet and tests of conservations law. Special interest is in search for exotics such as glueballs and meiktons. (2) is a so-called meson spectroscopy experiment. This is important not only in itself but also in identifying newly discovered states as exotics because exotics have often same quantum numbers as ordinary mesons. Contents are the following: glueballs and E/iota puzzles, spectrometer system, experiments, performance of the spectrometer, physics outputs, E/iota puzzles and πI experiment, future plans. (Mori, K.)

  15. Spectroscopy of muonic atoms and the proton radius puzzle

    Science.gov (United States)

    Antognini, Aldo

    2017-09-01

    We have measured several 2 S -2 P transitions in muonic hydrogen (μp), muonic deuterium (μd) and muonic helium ions (μ3He, μ4He). From muonic hydrogen we extracted a proton charge radius 20 times more precise than obtained from electron-proton scattering and hydrogen high-precision laser spectroscopy but at a variance of 7 σ from these values. This discrepancy is nowadays referred to as the proton radius puzzle. New insight has been recently provided by the first determination of the deuteron charge radius from laser spectroscopy of μd. The status of the proton charge radius puzzle including the new insights obtained by μd spectroscopy will be discussed. Work supported by the Swiss National Science Foundation SNF-200021-165854 and the ERC CoG. #725039.

  16. The puzzle of the ultra-high energy cosmic rays

    CERN Document Server

    Tkachev, I I

    2003-01-01

    In early years the cosmic ray studies were ahead of accelerator research, starting from the discovery of positrons, through muons, to that of pions and strange particles. Today we are facing the situation that the puzzling saga of cosmic rays of the highest energies may again unfold in the discovery of new physics, now beyond the Standard Model; or it may bring to life an "extreme" astrophysics. After a short review of the Greisen-Zatsepin-Kuzmin puzzle, I discuss different models which were suggested for its resolution. Are there any hints pointing to the correct model? I argue that the small-scale clustering of arrival directions of cosmic rays gives a clue, and BL Lacs are the probable sources of the observed events. (58 refs).

  17. The Monotonicity Puzzle: An Experimental Investigation of Incentive Structures

    Directory of Open Access Journals (Sweden)

    Jeannette Brosig

    2010-05-01

    Full Text Available Non-monotone incentive structures, which - according to theory - are able to induce optimal behavior, are often regarded as empirically less relevant for labor relationships. We compare the performance of a theoretically optimal non-monotone contract with a monotone one under controlled laboratory conditions. Implementing some features relevant to real-world employment relationships, our paper demonstrates that, in fact, the frequency of income-maximizing decisions made by agents is higher under the monotone contract. Although this observed behavior does not change the superiority of the non-monotone contract for principals, they do not choose this contract type in a significant way. This is what we call the monotonicity puzzle. Detailed investigations of decisions provide a clue for solving the puzzle and a possible explanation for the popularity of monotone contracts.

  18. Does Intrinsic Habit Formation Actually Resolve the Equity Premium Puzzle?

    OpenAIRE

    David A. Chapman

    2002-01-01

    Constantinides (1990) describes a simple model of intrinsic habit formation that appears to resolve the "equity premium puzzle" of Mehra and Prescott (1985). This finding is particularly important, since it has motivated a broader consideration of the implications of habit formation preferences in dynamic equilibrium models. However, consumption growth actually behaves very differently pre- and post-1948, and the explanatory power of the habit formation model is driven by the pre-1948 data. U...

  19. Can Equity Volatility Explain the Global Loan Pricing Puzzle?

    OpenAIRE

    Lewis Gaul; Pinar Uysal

    2013-01-01

    This paper examines whether unobservable differences in firm volatility are responsible for the global loan pricing puzzle, which is the observation that corporate loan interest rates appear to be lower in Europe than in the United States. We analyze whether equity volatility, an error prone measure of firm volatility, can explain this difference in loan spreads. We show that using equity volatility in OLS regressions will result in biased and inconsistent estimates of the difference in U.S. ...

  20. Can the magnetic moment contribution explain the Ay puzzle?

    International Nuclear Information System (INIS)

    Stoks, V.G.

    1998-01-01

    We evaluate the full one-photon-exchange Born amplitude for Nd scattering. We include the contributions due to the magnetic moment of the proton or neutron, and the magnetic moment and quadrupole moment of the deuteron. It is found that the inclusion of the magnetic-moment interaction in the theoretical description of the Nd scattering observables cannot resolve the long-standing A y puzzle. copyright 1998 The American Physical Society

  1. The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?

    Science.gov (United States)

    Deponte, Marcel

    2017-11-20

    Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids, and iron-sulfur clusters. In addition, glutathione affects oxidative protein folding and redox signaling. Here, I try to provide an overview on the relevance of glutathione-dependent pathways with an emphasis on quantitative data. Recent Advances: Intracellular redox measurements reveal that the cytosol, the nucleus, and mitochondria contain very little glutathione disulfide and that oxidative challenges are rapidly counterbalanced. Genetic approaches suggest that iron metabolism is the centerpiece of the glutathione puzzle in yeast. Furthermore, recent biochemical studies provide novel insights on glutathione transport processes and uncoupling mechanisms. Which parts of the glutathione puzzle are most relevant? Does this explain the high intracellular concentrations of reduced glutathione? How can iron-sulfur cluster biogenesis, oxidative protein folding, or redox signaling occur at high glutathione concentrations? Answers to these questions not only seem to depend on the organism, cell type, and subcellular compartment but also on different ideologies among researchers. A rational approach to compare the relevance of glutathione-dependent pathways is to combine genetic and quantitative kinetic data. However, there are still many missing pieces and too little is known about the compartment-specific repertoire and concentration of numerous metabolites, substrates, enzymes, and transporters as well as rate constants and enzyme kinetic patterns. Gathering this information might require the development of novel tools but is crucial to address potential kinetic competitions and to decipher uncoupling mechanisms to solve the glutathione puzzle. Antioxid. Redox Signal

  2. Puzzling with potential: dynamic testing of analogical reasoning in children

    OpenAIRE

    Stevenson, Claire Elisabeth

    2012-01-01

    Assessment procedures are frequent in children's school careers; however, measuring potential for learning has remained a puzzle. Dynamic testing is a method to assess cognitive potential that includes training in the assessment process. The goal of this thesis project was to develop a new dynamic test of analogical reasoning for school children. The main aims were to (1) investigate factors that influence children’s differences in performance and change during dynamic testing and (2) examine...

  3. PUZZLES – A CREATIVE WAY OF DEVELOPMENT OF LOGICAL THINKING

    Directory of Open Access Journals (Sweden)

    Milková, Eva

    2011-12-01

    Full Text Available Logical thinking of students should be enhanced at all levels of their studies. There are many possibilities how to achieve it. In the paper one possible way within the subjects “Discrete Mathematics” and “Discrete Methods and Optimization” dealing with graph theory and combinatorial optimization will be presented. These mathematical disciplines are powerful tools for teachers allowing them to develop logical thinking of students, increase their imagination and make them familiar with solutions to various problems. Thanks the knowledge gained within the subjects students should be able to describe various practical situations with the aid of graphs, solve the given problem expressed by the graph, and translate the solution back into the initial situation. Student engagement is crucial for successful education. Practical tasks and puzzles attract students to know more about the explained subject matter and to apply gained knowledge. There are an endless number of enjoyable tasks, puzzles and logic problems in books like “Mathematics is Fun”, in riddles magazines and on the Internet. In the paper, as an inspiration, four puzzles developing logical thinking appropriate to be solved using graph theory and combinatorial optimization will be introduced. On these puzzles of different level of difficulty the students’ ability to find out the appropriate graph-representation of the given task and solve it will be discussed as well. The author of the paper has been prepared with her students various multimedia applications dealing with objects appropriate to subject matter for more than 15 years. In the paper we also discuss a benefit of multimedia applications used as a support of subjects “Discrete Mathematics” and “Discrete Methods and Optimization”.

  4. Understanding the Puzzling Risk-Return Relationship for Housing

    OpenAIRE

    Lu Han

    2013-01-01

    Standard theory predicts a positive relationship between risk and return, yet recent data show that housing returns vary positively with risk in some markets but negatively in others. This paper rationalizes these cross-market differences in the risk-return relationship for housing, and in so doing, explains the puzzling negative relationship. The paper shows that when the current house provides a hedge against the risk associated with the future housing consumption, households are willing to...

  5. Puzzles, paradoxes, and problem solving an introduction to mathematical thinking

    CERN Document Server

    Reba, Marilyn A

    2014-01-01

    Graphs: Puzzles and Optimization Graphical Representation and Search Greedy Algorithms and Dynamic Programming Shortest Paths, DNA Sequences, and GPS Systems Routing Problems and Optimal Circuits Traveling Salesmen and Optimal Orderings Vertex Colorings and Edge Matchings Logic: Rational Inference and Computer Circuits Inductive and Deductive Arguments Deductive Arguments and Truth-Tables Deductive Arguments and Derivations Deductive Logic and Equivalence Modeling Using Deductive Logic Probability: Predictions and Expectations Probability and Counting Counting and Unordered Outcomes Independen

  6. Supersymmetry, the flavour puzzle and rare B decays

    Energy Technology Data Exchange (ETDEWEB)

    Straub, David Michael

    2010-07-14

    The gauge hierarchy problem and the flavour puzzle belong to the most pressing open questions in the Standard Model of particle physics. Supersymmetry is arguably the most popular framework of physics beyond the Standard Model and provides an elegant solution to the gauge hierarchy problem; however, it aggravates the flavour puzzle. In the first part of this thesis, I discuss several approaches to address the flavour puzzle in the minimal supersymmetric extension of the Standard Model and experimental tests thereof: supersymmetric grand unified theories with a unification of Yukawa couplings at high energies, theories with minimal flavour violation and additional sources of CP violation and theories with gauge mediation of supersymmetry breaking and a large ratio of Higgs vacuum expectation values. In the second part of the thesis, I discuss the phenomenology of two rare B meson decay modes which are promising probes of physics beyond the Standard Model: The exclusive B {yields} K{sup *}l{sup +}l{sup -} decay, whose angular decay distribution will be studied at LHC and gives access to a large number of observables and the b{yields}s{nu}anti {nu} decays, which are in the focus of planned high-luminosity Super B factories. I discuss the predictions for these observables in the Standard Model and their sensitivity to New Physics. (orig.)

  7. Food puzzles for cats: Feeding for physical and emotional wellbeing.

    Science.gov (United States)

    Dantas, Leticia Ms; Delgado, Mikel M; Johnson, Ingrid; Buffington, Ca Tony

    2016-09-01

    Many pet cats are kept indoors for a variety of reasons (eg, safety, health, avoidance of wildlife predation) in conditions that are perhaps the least natural to them. Indoor housing has been associated with health issues, such as chronic lower urinary tract signs, and development of problem behaviors, which can cause weakening of the human-animal bond and lead to euthanasia of the cat. Environmental enrichment may mitigate the effects of these problems and one approach is to take advantage of cats' natural instinct to work for their food. In this article we aim to equip veterinary professionals with the tools to assist clients in the use of food puzzles for their cats as a way to support feline physical health and emotional wellbeing. We outline different types of food puzzles, and explain how to introduce them to cats and how to troubleshoot challenges with their use. The effect of food puzzles on cats is a relatively new area of study, so as well as reviewing the existing empirical evidence, we provide case studies from our veterinary and behavioral practices showing health and behavioral benefits resulting from their use. © The Author(s) 2016.

  8. Decodoku: Quantum error rorrection as a simple puzzle game

    Science.gov (United States)

    Wootton, James

    To build quantum computers, we need to detect and manage any noise that occurs. This will be done using quantum error correction. At the hardware level, QEC is a multipartite system that stores information non-locally. Certain measurements are made which do not disturb the stored information, but which do allow signatures of errors to be detected. Then there is a software problem. How to take these measurement outcomes and determine: a) The errors that caused them, and (b) how to remove their effects. For qubit error correction, the algorithms required to do this are well known. For qudits, however, current methods are far from optimal. We consider the error correction problem of qubit surface codes. At the most basic level, this is a problem that can be expressed in terms of a grid of numbers. Using this fact, we take the inherent problem at the heart of quantum error correction, remove it from its quantum context, and presented in terms of simple grid based puzzle games. We have developed three versions of these puzzle games, focussing on different aspects of the required algorithms. These have been presented and iOS and Android apps, allowing the public to try their hand at developing good algorithms to solve the puzzles. For more information, see www.decodoku.com. Funding from the NCCR QSIT.

  9. Learning structural bioinformatics and evolution with a snake puzzle

    Directory of Open Access Journals (Sweden)

    Gonzalo S. Nido

    2016-12-01

    Full Text Available We propose here a working unit for teaching basic concepts of structural bioinformatics and evolution through the example of a wooden snake puzzle, strikingly similar to toy models widely used in the literature of protein folding. In our experience, developed at a Master’s course at the Universidad Autónoma de Madrid (Spain, the concreteness of this example helps to overcome difficulties caused by the interdisciplinary nature of this field and its high level of abstraction, in particular for students coming from traditional disciplines. The puzzle will allow us discussing a simple algorithm for finding folded solutions, through which we will introduce the concept of the configuration space and the contact matrix representation. This is a central tool for comparing protein structures, for studying simple models of protein energetics, and even for a qualitative discussion of folding kinetics, through the concept of the Contact Order. It also allows a simple representation of misfolded conformations and their free energy. These concepts will motivate evolutionary questions, which we will address by simulating a structurally constrained model of protein evolution, again modelled on the snake puzzle. In this way, we can discuss the analogy between evolutionary concepts and statistical mechanics that facilitates the understanding of both concepts. The proposed examples and literature are accessible, and we provide supplementary material (see ‘Data Availability’ to reproduce the numerical experiments. We also suggest possible directions to expand the unit. We hope that this work will further stimulate the adoption of games in teaching practice.

  10. Supersymmetry, the flavour puzzle and rare B decays

    International Nuclear Information System (INIS)

    Straub, David Michael

    2010-01-01

    The gauge hierarchy problem and the flavour puzzle belong to the most pressing open questions in the Standard Model of particle physics. Supersymmetry is arguably the most popular framework of physics beyond the Standard Model and provides an elegant solution to the gauge hierarchy problem; however, it aggravates the flavour puzzle. In the first part of this thesis, I discuss several approaches to address the flavour puzzle in the minimal supersymmetric extension of the Standard Model and experimental tests thereof: supersymmetric grand unified theories with a unification of Yukawa couplings at high energies, theories with minimal flavour violation and additional sources of CP violation and theories with gauge mediation of supersymmetry breaking and a large ratio of Higgs vacuum expectation values. In the second part of the thesis, I discuss the phenomenology of two rare B meson decay modes which are promising probes of physics beyond the Standard Model: The exclusive B → K * l + l - decay, whose angular decay distribution will be studied at LHC and gives access to a large number of observables and the b→sνanti ν decays, which are in the focus of planned high-luminosity Super B factories. I discuss the predictions for these observables in the Standard Model and their sensitivity to New Physics. (orig.)

  11. A possible explanation of the 'exchange rate disconnect puzzle': A common solution to three major macroeconomic puzzles?

    OpenAIRE

    Horioka, Charles Yuji; Ford, Nicholas

    2016-01-01

    Meese and Rogoff (1983) and subsequent studies find that economic fundamentals are apparently not able to explain exchange rate movements, but we argue that this so-called "Exchange Rate Disconnect Puzzle" arose because researchers such as Meese and Rogoff (1983) did not use the right fundamentals and because they did not allow for the forward-looking nature of exchange rate determination. Further, because they apparently were not aware that financial markets by themselves could not equalise ...

  12. 3D satellite puzzles for young and old kids

    Science.gov (United States)

    Biondi, Riccardo; Galoforo, Germana

    2017-04-01

    The Italian Space Agency (ASI) is active in outreach willing to increase the interest of young generations and general public toward the space activities. ASI proposes educational programmes for supporting and encouraging the development of European society based on knowledge, inspiring and motivating the young generations. One of the initiatives promoted by ASI on this regards is the 3D satellite puzzles. The idea was born in 2007 from the will to conceive an educational product for promoting and explaining to students the small all-Italian mission AGILE (Astrorivelatore Gamma ad Immagini ultra Leggero) thought as a tool for students aged 8-13. Working with this slot of students is very productive in terms of the imprints left on the kids, in fact it is useful to produce things they can use, touch and play with, with an active approach instead of a passive one. Therefore it was decided to produce something that kids could build and use at home with their parents or friends, or all together at school with teachers and mates. Other puzzles followed AGILE, one about the COSMO-SkyMED satellites about Earth Observation and also a broader one of the International Space Station. During these 10 years the puzzles were mostly used as outreach tools for school children, but they surprisingly received a great success also within older generations. So far the 3D puzzles have been printed in more than 10 thousand copies and distributed for free to students of hundreds of schools in Italy, and to the general public through science associations, planetaria and museums. Recently they have been used also during special events such as the international Geoscience Communication School (as best practice outreach tool), the EXPO 2015 and the European Researcheŕs Night at the Parlamentarium in Brussels 2016. While the students are building the puzzles, the tutor explains them the different components that they are assembling, what the importance of the satellite is and how it works

  13. Europe vs. the U.S. A New Look at the Syndicated Loan Pricing Puzzle

    OpenAIRE

    Burietz, Aurore; Oosterlinck, Kim; Szafarz, Ariane

    2017-01-01

    According to the syndicated loan pricing puzzle (Carey and Nini, Journal of Finance, 2007) interest rates charged to corporate borrowers are lower in Europe than in the U.S. Our investigation suggests that controlling for region-specific credit ratings makes the Europe-U.S. gap insignificant, and solves the puzzle. We speculate that the puzzle originates from the lack of uniformity of accounting standards.

  14. Nursing education: current themes, puzzles and paradoxes.

    Science.gov (United States)

    Tanner, Christine A

    2007-01-01

    have been tremendously changed, with an emphasis on case-based instruction, integrating distance delivery technologies, and using simulation, drawing on best practices in the development of these approaches (Billings, et al., 2001; Issenberg, et al .2005; Jeffries, 2005). OCNE leaders obtained funding from Kaiser Permanente Northwest to begin the long, collaborative, consensus building process to transform clinical education. Evaluation has and will continue to be an integral part of this work, with an eye to adding to our collective knowledge of best practices in nursing education. We see evidence of similar efforts, mostly state or regional, in order to build on prior alliances, acknowledge geographic particularities, and respond to local needs in many other parts of the country, from Hawaii to New Jersey, Texas to Montana. The nursing shortage has been a primary catalyst. It has captured the interest of potential funders, individual donors, foundations to the Federal government. The keys are collaboration and a collective voice for nursing, a willingness to work through long-standing and divisive issues, and most importantly, a moral commitment to the populations we serve.

  15. Robust Sex Differences in Jigsaw Puzzle Solving-Are Boys Really Better in Most Visuospatial Tasks?

    Science.gov (United States)

    Kocijan, Vid; Horvat, Marina; Majdic, Gregor

    2017-01-01

    Sex differences are consistently reported in different visuospatial tasks with men usually performing better in mental rotation tests while women are better on tests for memory of object locations. In the present study, we investigated sex differences in solving jigsaw puzzles in children. In total 22 boys and 24 girls were tested using custom build tablet application representing a jigsaw puzzle consisting of 25 pieces and featuring three different pictures. Girls outperformed boys in solving jigsaw puzzles regardless of the picture. Girls were faster than boys in solving the puzzle, made less incorrect moves with the pieces of the puzzle, and spent less time moving the pieces around the tablet. It appears that the strategy of solving the jigsaw puzzle was the main factor affecting differences in success, as girls tend to solve the puzzle more systematically while boys performed more trial and error attempts, thus having more incorrect moves with the puzzle pieces. Results of this study suggest a very robust sex difference in solving the jigsaw puzzle with girls outperforming boys by a large margin.

  16. Robust Sex Differences in Jigsaw Puzzle Solving—Are Boys Really Better in Most Visuospatial Tasks?

    Science.gov (United States)

    Kocijan, Vid; Horvat, Marina; Majdic, Gregor

    2017-01-01

    Sex differences are consistently reported in different visuospatial tasks with men usually performing better in mental rotation tests while women are better on tests for memory of object locations. In the present study, we investigated sex differences in solving jigsaw puzzles in children. In total 22 boys and 24 girls were tested using custom build tablet application representing a jigsaw puzzle consisting of 25 pieces and featuring three different pictures. Girls outperformed boys in solving jigsaw puzzles regardless of the picture. Girls were faster than boys in solving the puzzle, made less incorrect moves with the pieces of the puzzle, and spent less time moving the pieces around the tablet. It appears that the strategy of solving the jigsaw puzzle was the main factor affecting differences in success, as girls tend to solve the puzzle more systematically while boys performed more trial and error attempts, thus having more incorrect moves with the puzzle pieces. Results of this study suggest a very robust sex difference in solving the jigsaw puzzle with girls outperforming boys by a large margin. PMID:29109682

  17. The Hiroshima neutron dosimetry enigma: Missing puzzle piece No. 6

    International Nuclear Information System (INIS)

    Gold, Raymond

    1999-01-01

    More than a decade has elapsed since the serious nature of the discrepancy between neutron dosimetry experiments (E) and neutron transport calculations (C) for the Hiroshima site was identified. Since that time extensive efforts to resolve this Hiroshima neutron dosimetry enigma have not only failed, but now demonstrate that the magnitude of this discrepancy is much greater than initially estimated. The currently evaluated E/C ratio for thermal neutron fluence at the Hiroshima site increases rapidly with increasing slant range from the epicenter. In the slant range region beyond 1000 m, E/C exceeds unity by one to two orders of magnitude depending on the specific dosimetry data that are utilized. Principal features that characterize the Hiroshima neutron dosimetry enigma are summarized. Puzzle Piece No. 6: In-situ production and Prompt fallout of radionuclides from Little Boy is advanced as a possible contributory phenomenon to this enigma. (The atom bomb detonated over Hiroshima was called Little Boy.) Measurements of 60 Co and 152 Eu specific activity at the Hiroshima site are used to obtain order of magnitude numerical estimates that show this conjecture is plausible. Comparison of different 60 Co measurements at the Hiroshima site reveals that the variation of E/C with slant range depends on the method used to quantify 60 Co specific activity as well as the type of dosimetry samples that are employed. These 60 Co comparisons lend additional qualitative credence to this conjecture. Within the limits of presently available data, these assessments show that Puzzle Piece No. 6 qualitatively satisfies the principal features that characterize the Hiroshima neutron dosimetry enigma. Nevertheless, current lack of data prevent this conjecture from being conclusively confirmed or refuted. Consequently, specific recommendations are advanced to resolve the Hiroshima neutron dosimetry enigma with emphasis on experimental tests that can quantitatively evaluate Puzzle Piece

  18. ysteries, Puzzles, and Paradoxes in Quantum Mechanics. Proceedings

    International Nuclear Information System (INIS)

    Rodolfo, B.

    1999-01-01

    These proceedings represent papers presented at the Mysteries, Puzzles, and Paradoxes in Quantum Mechanics Workshop held in Italy, in August 1998. The Workshop was devoted to recent experimental and theoretical advances such as new interference, effects, the quantum eraser, non-disturbing and Schroedinger-cat-like states, experiments, EPR correlations, teleportation, superluminal effects, quantum information and computing, locality and causality, decoherence and measurement theory. Tachyonic information transfer was also discussed. There were 45 papers presented at the conference,out of which 2 have been abstracted for the Energy, Science and Technology database

  19. Precautionary Borrowing and the Credit Card Debt Puzzle

    DEFF Research Database (Denmark)

    Druedahl, Jeppe; Jørgensen, Casper Nordal

    2015-01-01

    This paper addresses the credit card debt puzzle using a generalization of the buffer-stock consumption model with long-term revolving debt contracts. Closely resembling actual US credit card law, we assume that card issuers can always deny their cardholders access to new debt, but that they cannot...... to simultaneously hold positive gross debt and positive gross assets even though the interest rate on the debt is much higher than the return rate on the assets. Including a risk of being excluded from new borrowing which is positively correlated with unemployment, we are able to simultaneously explain...

  20. The Puzzle of a Marble in a Spinning Pipe

    Science.gov (United States)

    2015-05-01

    MAY 2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE The Puzzle of a Marble in a Spinning Pipe 5a. CONTRACT...Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT What trajectory does a marble follow if it is held...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Physics Education 50 (3) 279 1. Problem statement A marble is placed one-third of the length along a

  1. Hybrid Charmonium and the p-n Puzzle

    International Nuclear Information System (INIS)

    Kisslinger, L.S.; Parno, D.; Riordan, S.

    2008-01-01

    Using the method of QCD sum rules, we estimate the energy of the lowest hybrid charmonium state, and find it to be at the energy of the Ψ (2S) state, about 600 MeV above the J/Ψ(1S) state. Since our solution is not consistent with a pure hybrid at this energy, we conclude that the Ψ (2S) state is probably an admixed cc - and hybrid cc - g state. From this conjecture, we find a possible explanation of the famous ρ-p puzzle.

  2. The Puzzle of Non-proliferation and Disarmament (Part II)

    International Nuclear Information System (INIS)

    Ponga, J. de

    2011-01-01

    Since, in 1945, the World was aware of the devastating power of nuclear weapons there have been many initiatives at international level to avoid nuclear weapon proliferation: the foundation of the IAEA, the NPT, the Safeguards Agreements, the Nuclear Weapon Free Zones, the treaties banning nuclear tests or the export control regime of the NSG, among others. This article aims to offer a general picture of all of them as pieces of a puzzle the purpose of which is not to allow gaps to non pacific uses of nuclear energy. (Author)

  3. Tiny bubbles challenge giant turbines: Three Gorges puzzle.

    Science.gov (United States)

    Li, Shengcai

    2015-10-06

    Since the birth of the first prototype of the modern reaction turbine, cavitation as conjectured by Euler in 1754 always presents as a challenge. Following his theory, the evolution of modern reaction (Francis and Kaplan) turbines has been completed by adding the final piece of the element 'draft-tube' that enables turbines to explore water energy at efficiencies of almost 100%. However, during the last two and a half centuries, with increasing unit capacity and specific speed, the problem of cavitation has been manifested and complicated by the draft-tube surges rather than being solved. Particularly, during the last 20 years, the fierce competition in the international market for extremely large turbines with compact design has encouraged the development of giant Francis turbines of 700-1000 MW. The first group (24 units) of such giant turbines of 700 MW each was installed in the Three Gorges project. Immediately after commission, a strange erosion phenomenon appeared on the guide vane of the machines that has puzzled professionals. From a multi-disciplinary analysis, this Three Gorges puzzle could reflect an unknown type of cavitation inception presumably triggered by turbulence production from the boundary-layer streak transitional process. It thus presents a fresh challenge not only to this old turbine industry, but also to the fundamental sciences.

  4. Yet another possible explanation of the solar-neutrino puzzle

    International Nuclear Information System (INIS)

    Kolb, E.W.; Turner, M.S.; Walker, T.P.

    1986-01-01

    Mikheyev and Smirnov have shown that the interactions of neutrinos with matter can result in the conversion of electron neutrinos produced in the center of the sun to muon neutrinos. Bethe has exploited this and has pointed out that the solar-neutrino puzzle can be resolved if the mass difference squared of the two neutrinos is m 2 2 -m 2 1 approx.=6x10 -5 eV 2 , and the mixing angle satisfies sin THETAsub(v)>0.0065. We discuss a qualitatively different solution to the solar-neutrino puzzle which requires 1.0x10 -8 2 2 -m 2 1 )(sin 2 2THETAsub(v)/cos2THETAsub(v)) -8 eV 2 . Our solutions result in a much smaller flux of neutrinos from the p-p process than predicted by standard solar models, while Bethe's solution results in a flux of neutrinos from the p-p process that is about the same as standard solar models. (orig.)

  5. May heavy neutrinos solve underground and cosmic-ray puzzles?

    International Nuclear Information System (INIS)

    Belotsky, K. M.; Fargion, D.; Khlopov, M. Yu.; Konoplich, R. V.

    2008-01-01

    Primordial heavy neutrinos of the fourth generation might explain different astrophysical puzzles. The simplest fourth-neutrino scenario is consistent with known fourth-neutrino physics, cosmic ray antimatter, cosmic gamma fluxes, and positive signals in underground detectors for a very narrow neutrino mass window (46–47 GeV). However, accounting for the constraint of underground experiment CDMS prohibits solution of cosmic-ray puzzles in this scenario. We have analyzed extended heavy-neutrino models related to the clumpiness of neutrino density, new interactions in heavy-neutrino annihilation, neutrino asymmetry, and neutrino decay. We found that, in these models, the cosmic-ray imprint may fit the positive underground signals in DAMA/Nal experiment in the entire mass range 46–70 GeV allowed from uncertainties of electroweak parameters, while satisfaction of the CDMS constraint reduces the mass range to around 50 GeV, where all data can come to consent in the framework of the considered hypothesis.

  6. May heavy neutrinos solve underground and cosmic-ray puzzles?

    International Nuclear Information System (INIS)

    Belotsky, K. M.; Fargion, D.; Khlopov, M. Yu.; Konoplich, R. V.

    2008-01-01

    Primordial heavy neutrinos of the fourth generation might explain different astrophysical puzzles. The simplest fourth-neutrino scenario is consistent with known fourth-neutrino physics, cosmic ray antimatter, cosmic gamma fluxes, and positive signals in underground detectors for a very narrow neutrino mass window (46-47 GeV). However, accounting for the constraint of underground experiment CDMS prohibits solution of cosmic-ray puzzles in this scenario. We have analyzed extended heavy-neutrino models related to the clumpiness of neutrino density, new interactions in heavy-neutrino annihilation, neutrino asymmetry, and neutrino decay. We found that, in these models, the cosmic-ray imprint may fit the positive underground signals in DAMA/Nal experiment in the entire mass range 46-70 GeV allowed from uncertainties of electroweak parameters, while satisfaction of the CDMS constraint reduces the mass range to around 50 GeV, where all data can come to consent in the framework of the considered hypothesis

  7. The puzzling unsolved mysteries of liquid water: Some recent progress

    Science.gov (United States)

    Stanley, H. E.; Kumar, P.; Xu, L.; Yan, Z.; Mazza, M. G.; Buldyrev, S. V.; Chen, S.-H.; Mallamace, F.

    2007-12-01

    Water is perhaps the most ubiquitous, and the most essential, of any molecule on earth. Indeed, it defies the imagination of even the most creative science fiction writer to picture what life would be like without water. Despite decades of research, however, water's puzzling properties are not understood and 63 anomalies that distinguish water from other liquids remain unsolved. We introduce some of these unsolved mysteries, and demonstrate recent progress in solving them. We present evidence from experiments and computer simulations supporting the hypothesis that water displays a special transition point (which is not unlike the “tipping point” immortalized by Malcolm Gladwell). The general idea is that when the liquid is near this “tipping point,” it suddenly separates into two distinct liquid phases. This concept of a new critical point is finding application to other liquids as well as water, such as silicon and silica. We also discuss related puzzles, such as the mysterious behavior of water near a protein.

  8. Yet another possible explanation of the solar-neutrino puzzle

    International Nuclear Information System (INIS)

    Kolb, E.W.; Turner, M.S.; Walker, T.P.

    1986-04-01

    Mikheyev and Smirnov have shown that the interactions of neutrinos with matter can result in the conversion of electron neutrinos produced in the center of the sun to muon neutrinos. Bethe has exploited this and has pointed out that the solar-neutrino puzzle can be resolved if the mass difference squared of the two neutrinos is m 2 2 - m 1 2 approx. = 6 x 10 -5 eV 2 , and the mixing angle satisfies sin theta/sub v/ > 0.0065. We discuss a qualitatively different solution to the solar-neutrino puzzle which requires 1.0 x 10 -8 2 2 - m 1 2 ) (sin 2 2theta/sub v//cos 2theta/sub v/) -8 eV 2 . Our solutions result in a much smaller flux of neutrinos from the p - p process than predicted by standard solar models, while Bethe's solution results in a flux of neutrinos from the p - process that is about the same as standard solar models

  9. Simultaneous explanation of the RK and R (D (*)) puzzles

    Science.gov (United States)

    Bhattacharya, Bhubanjyoti; Datta, Alakabha; London, David; Shivashankara, Shanmuka

    2015-03-01

    At present, there are several hints of lepton flavor non-universality. The LHCb Collaboration has measured RK ≡ B (B+ →K+μ+μ-) / B (B+ →K+e+e-), and the BaBar Collaboration has measured R (D (*)) ≡ B (B bar →D (*) +τ-νbarτ) / B (B bar →D (*) +ℓ-νbarℓ) (ℓ = e , μ). In all cases, the experimental results differ from the standard model predictions by 2- 3 σ. Recently, an explanation of the RK puzzle was proposed in which new physics (NP) generates a neutral-current operator involving only third-generation particles. Now, assuming the scale of NP is much larger than the weak scale, this NP operator must be made invariant under the full SU (3)C × SU (2)L × U(1)Y gauge group. In this Letter, we note that, when this is done, a new charged-current operator can appear, and this can explain the R (D (*)) puzzle. A more precise measurement of the double ratio R (D) / R (D*) can rule out this model.

  10. Application-Based Crossword Puzzles: Players’ Perception and Vocabulary Retention

    Directory of Open Access Journals (Sweden)

    Dzulfikri Dzulfikri

    2016-09-01

    Full Text Available This study investigates the perceptions of students towards Application-Based Crossword Puzzles and how playing this game can affect the development of vocabulary amongst students. Drawing on Vygostky’s Socio-Cultural Theory which states that the human mind is mediated by cultural artifacts, the nature of this game poses challenges and builds curiosity, allowing players to pay more attention to the words to fill in the boxes which subsequently enhances their retention of vocabulary. This game has very good potential to build positive perceptions and to develop cognition in the linguistic domain of players, i.e. the amount of their vocabulary. In this study, the researcher conducted interviews with eligible or selected student players to find out their perceptions toward this game and administered a vocabulary test to find out how this game had added to the retention in memory of new words acquired by the players from the game. The study findings showed that the participants perceive this game positively and it affects the players’ vocabulary retention positively as indicated by their test results. It is recommended that English teachers consider using Application-Based Crossword Puzzles to help students build their vocabularies especially as part of extracurricular activities.

  11. Using the Tower of Hanoi Puzzle to Infuse Your Mathematics Classroom with Computer Science Concepts

    Science.gov (United States)

    Marzocchi, Alison S.

    2016-01-01

    This article suggests that logic puzzles, such as the well-known Tower of Hanoi puzzle, can be used to introduce computer science concepts to mathematics students of all ages. Mathematics teachers introduce their students to computer science concepts that are enacted spontaneously and subconsciously throughout the solution to the Tower of Hanoi…

  12. An Alternative Evaluation: Online Puzzle as a Course-End Activity

    Science.gov (United States)

    Genç, Zülfü; Aydemir, Emrah

    2015-01-01

    Purpose: The purpose of this study is to determine whether the use of online puzzles in the instructional process has an effect on student achievement and learning retention. This study examined students ' perception and experiences on use of puzzle as an alternative evaluation tool. To achieve this aim, the following hypotheses were tested: using…

  13. Studying the proton 'radius' puzzle with μp elastic scattering

    International Nuclear Information System (INIS)

    Gilman, R.

    2013-01-01

    The disagreement between the proton radius determined from muonic hydrogen and from electronic measurements is called the proton radius puzzle. The resolution of the puzzle remains unclear and appears to require new experimental results. An experiment to measure muon-proton elastic scattering is presented here

  14. Crossword Puzzle Makes It Fun: Introduce Green Manufacturing in Wood Technology Courses

    Science.gov (United States)

    Iley, John L.; Hague, Doug

    2012-01-01

    Sustainable, or "green," manufacturing and its practices are becoming more and more a part of today's industry, including wood product manufacturing. This article provides introductory information on green manufacturing in wood technology and a crossword puzzle based on green manufacturing terms. The authors use the puzzle at the college level to…

  15. The King and Prisoner Puzzle: A Way of Introducing the Components of Logical Structures

    Science.gov (United States)

    Roh, Kyeong Hah; Lee, Yong Hah; Tanner, Austin

    2016-01-01

    The purpose of this paper is to provide issues related to student understanding of logical components that arise when solving word problems. We designed a logic problem called the King and Prisoner Puzzle--a linguistically simple, yet logically challenging problem. In this paper, we describe various student solutions to the puzzle and discuss the…

  16. Puzzle-Based Learning in Engineering Mathematics: Students' Attitudes

    Science.gov (United States)

    Klymchuk, Sergiy

    2017-01-01

    The article reports on the results of two case studies on the impact of the regular use of puzzles as a pedagogical strategy in the teaching and learning of engineering mathematics. The intention of using puzzles is to engage students' emotions, creativity and curiosity and also to enhance their generic thinking skills and lateral thinking…

  17. What Puzzles Teachers in Rio de janeiro, and What Keeps Them Going?

    Science.gov (United States)

    Lyra, Isolina; Fish, Solange; Braga, Walewska Gomes

    2003-01-01

    Focuses on the key mechanism of "puzzling" in Exploratory Practice (EP), a form of practitioner research, and the critical issue of sustainability in the context of volunteer teacher development work in Rio de Janeiro, Brazil. Investigated puzzles (concerns) of language teachers and grouped them into six categories; motivation, anxiety,…

  18. On Non-Parallelizable Deterministic Client Puzzle Scheme with Batch Verification Modes

    NARCIS (Netherlands)

    Tang, Qiang; Jeckmans, Arjan

    A (computational) client puzzle scheme enables a client to prove to a server that a certain amount of computing resources (CPU cycles and/or Memory look-ups) has been dedicated to solve a puzzle. Researchers have identified a number of potential applications, such as constructing timed cryptography,

  19. Making Peer-Assisted Content Distribution Robust to Collusion Using Bandwidth Puzzles

    Science.gov (United States)

    Reiter, Michael K.; Sekar, Vyas; Spensky, Chad; Zhang, Zhenghao

    Many peer-assisted content-distribution systems reward a peer based on the amount of data that this peer serves to others. However, validating that a peer did so is, to our knowledge, an open problem; e.g., a group of colluding attackers can earn rewards by claiming to have served content to one another, when they have not. We propose a puzzle mechanism to make contribution-aware peer-assisted content distribution robust to such collusion. Our construction ties solving the puzzle to possession of specific content and, by issuing puzzle challenges simultaneously to all parties claiming to have that content, our mechanism prevents one content-holder from solving many others' puzzles. We prove (in the random oracle model) the security of our scheme, describe our integration of bandwidth puzzles into a media streaming system, and demonstrate the resulting attack resilience via simulations.

  20. An Empirical Evaluation of Puzzle-Based Learning as an Interest Approach for Teaching Introductory Computer Science

    Science.gov (United States)

    Merrick, K. E.

    2010-01-01

    This correspondence describes an adaptation of puzzle-based learning to teaching an introductory computer programming course. Students from two offerings of the course--with and without the puzzle-based learning--were surveyed over a two-year period. Empirical results show that the synthesis of puzzle-based learning concepts with existing course…

  1. Gamma-ray bursts, a puzzle being resolved

    CERN Multimedia

    Piran, T

    1999-01-01

    Gamma Ray Bursts (GRBs), short and intense bursts of Gamma-Rays, have puzzled astrophysicists since their accidental discovery in the seventies. BATSE, launched in 1991, has established the cosmological origin of GRBs and has shown that they involve energies much higher than previously expected, corresponding to the most powerful explosions known in the Universe. The fireball model, which has been developed during the last ten years, explains most of the observed features of GRBs . According to this model, GRBs are produced in internal collisions of ejected matter flowing at ultra-relativistic energy. This ultra-relativistic motion reaches Lorentz factors of order 100 or more, higher than seen elsewhere in the Universe. The GRB afterglow was discovered in 1997. It was predicted by this model and it takes place when this relativistic flow is slowed down by the surrounding material. This model was confirmed recently with the discovery last January of the predicted prompt optical emission from GRB 990123. Unfort...

  2. The puzzling resilience of transnational organized criminal networks

    DEFF Research Database (Denmark)

    Leuprecht, Christian; Aulthouse, Andrew; Walther, Olivier

    2016-01-01

    international organized crime syndicate based in Jamaica, whose resilience proves particularly puzzling. We were curious to know whether there is any evidence that international borders have an effect on the structure of illicit networks that cross them. It turns out that transnational drug distribution......Why is transnational organized crime so difficult to dismantle? While organized crime networks within states have received some attention, actual transnational operations have not. In this article, we study the transnational drug and gun trafficking operations of the Shower Posse, a violent...... networks such as the Shower Posse rely on a small number of brokers whose role is to connect otherwise distinct domestic markets. Due to the high transaction costs associated with developing and maintaining transnational movement, the role of such brokers appears particularly important in facilitating...

  3. Interfacial depinning transitions in disordered media: revisiting an old puzzle

    International Nuclear Information System (INIS)

    Moglia, Belén; Albano, Ezequiel V; Villegas, Pablo; Muñoz, Miguel A

    2014-01-01

    Interfaces advancing through random media represent a number of different problems in physics, biology and other disciplines. Here, we study the pinning/depinning transition of the prototypical non-equilibrium interfacial model, i.e. the Kardar–Parisi–Zhang equation, advancing in a disordered medium. We will separately analyze the cases of positive and negative non-linearity coefficients, which are believed to exhibit qualitatively different behavior: the positive case shows a continuous transition that can be related to directed-percolation-depinning, while in the negative case there is a discontinuous transition and faceted interfaces appear. Some studies have argued from different perspectives that both cases share the same universal behavior. By using a number of computational and scaling techniques we will shed light on this puzzling situation and conclude that the two cases are intrinsically different. (paper)

  4. 'Super' Japanese site gears up to sole neutrino puzzle

    International Nuclear Information System (INIS)

    Normile, D.

    1995-01-01

    Ever since Wolfgang Pauli proposed the existence of neutrinos in 1930 to explain some puzzling features of the radioactive decay of certain atoms, expermentalists have labored hard to detect enough of the elusive particles to determine their properties. It took 26 years to prove that Pauli's particle even exits-a feat for which Frederick Reines of the University of California (UC), Irvine, won the Nobel Prize last month. Soon, however, physicists will be capturing neutrinos in unprecedented numbers in a 50,000-metric-ton tank that will fill with water starting next month. Researchers hope that this colossal waterbath will yield an answer to one of the most pressing questions is cosmology and high-energy physics: Do neutrinos have mass?The $100 million experiment, called Super-Kamiokande, in located in a lead mine west of Tokyo. This article describes the work to be conducted

  5. Ambiguity aversion and household portfolio choice puzzles: Empirical evidence.

    Science.gov (United States)

    Dimmock, Stephen G; Kouwenberg, Roy; Mitchell, Olivia S; Peijnenburg, Kim

    2016-03-01

    We test the relation between ambiguity aversion and five household portfolio choice puzzles: nonparticipation in equities, low allocations to equity, home-bias, own-company stock ownership, and portfolio under-diversification. In a representative US household survey, we measure ambiguity preferences using custom-designed questions based on Ellsberg urns. As theory predicts, ambiguity aversion is negatively associated with stock market participation, the fraction of financial assets in stocks, and foreign stock ownership, but it is positively related to own-company stock ownership. Conditional on stock ownership, ambiguity aversion is related to portfolio under-diversification, and during the financial crisis, ambiguity-averse respondents were more likely to sell stocks.

  6. Ambiguity aversion and household portfolio choice puzzles: Empirical evidence*

    Science.gov (United States)

    Dimmock, Stephen G.; Kouwenberg, Roy; Mitchell, Olivia S.; Peijnenburg, Kim

    2017-01-01

    We test the relation between ambiguity aversion and five household portfolio choice puzzles: nonparticipation in equities, low allocations to equity, home-bias, own-company stock ownership, and portfolio under-diversification. In a representative US household survey, we measure ambiguity preferences using custom-designed questions based on Ellsberg urns. As theory predicts, ambiguity aversion is negatively associated with stock market participation, the fraction of financial assets in stocks, and foreign stock ownership, but it is positively related to own-company stock ownership. Conditional on stock ownership, ambiguity aversion is related to portfolio under-diversification, and during the financial crisis, ambiguity-averse respondents were more likely to sell stocks. PMID:28458446

  7. THE PUZZLE TECHNIQUE, COOPERATIVE LEARNING STRATEGY TO IMPROVE ACADEMIC PERFORMANCE

    Directory of Open Access Journals (Sweden)

    M.ª José Mayorga Fernández

    2012-04-01

    Full Text Available This  article  presents  an  innovative  experience  carried  out  in  the  subject Pedagogical Bases of Special Education, a 4.5 credit core subject taught at the second year of the Degree in Physical Education Teacher Training (to be extinguish, based on the use of a methodological strategic in accordance with the new demands of the EEES. With the experience we pursue a double purpose: firstly, to present the technique of jigsaw or puzzle as a useful methodological strategy for university learning and, on the other hand, to show whether this strategy improves students results. Comparing the results with students previous year results shows that the performance of students who participated in the innovative experience has improved considerably, increasing their motivation and involvement towards the task.

  8. Diagnosing the Cause of Scientific Standstill, Unravelling the Needham Puzzle

    Institute of Scientific and Technical Information of China (English)

    刘迎秋; 刘春江

    2007-01-01

    There are diverse opinions about how to solve the Needham Puzzle. Such opinions or schools of thought can be roughly classified into three theories of a) geographical conditions, b) empirical trial and error, and c) private property rights. Although each school of thought makes sense, they all fail to fully uncover the main reason why, in modern history, China lagged behind western countries in the development of science and technology. In our opinion, the correct solution is to draw on historical experiences, integrate all schools of thought, proceed with an emphasis on the definition and protection of property rights, boost government investment in basic scientific research, strengthen government service functionality, actively develop NGOs, and open more widely to the outside world, with a view of pushing forward China’s scientific and technological innovation and accelerating the pace of China’s modernization.

  9. Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the Puzzle.

    Science.gov (United States)

    Trenti, Annalisa; Tedesco, Serena; Boscaro, Carlotta; Trevisi, Lucia; Bolego, Chiara; Cignarella, Andrea

    2018-03-15

    Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection, including endothelial healing in case of arterial injury and collateral vessel formation in ischemic tissue. Estrogen can exert potent modulation effects at all levels of the innate and adaptive immune systems. Their action is mediated by interaction with classical estrogen receptors (ERs), ERα and ERβ, as well as the more recently identified G-protein coupled receptor 30/G-protein estrogen receptor 1 (GPER1), via both genomic and non-genomic mechanisms. Emerging data from the literature suggest that estrogen deficiency in menopause is associated with an increased potential for an unresolved inflammatory status. In this review, we provide an overview through the puzzle pieces of how 17β-estradiol can influence the cardiovascular and immune systems.

  10. Why plants make puzzle cells, and how their shape emerges.

    Science.gov (United States)

    Sapala, Aleksandra; Runions, Adam; Routier-Kierzkowska, Anne-Lise; Das Gupta, Mainak; Hong, Lilan; Hofhuis, Hugo; Verger, Stéphane; Mosca, Gabriella; Li, Chun-Biu; Hay, Angela; Hamant, Olivier; Roeder, Adrienne Hk; Tsiantis, Miltos; Prusinkiewicz, Przemyslaw; Smith, Richard S

    2018-02-27

    The shape and function of plant cells are often highly interdependent. The puzzle-shaped cells that appear in the epidermis of many plants are a striking example of a complex cell shape, however their functional benefit has remained elusive. We propose that these intricate forms provide an effective strategy to reduce mechanical stress in the cell wall of the epidermis. When tissue-level growth is isotropic, we hypothesize that lobes emerge at the cellular level to prevent formation of large isodiametric cells that would bulge under the stress produced by turgor pressure. Data from various plant organs and species support the relationship between lobes and growth isotropy, which we test with mutants where growth direction is perturbed. Using simulation models we show that a mechanism actively regulating cellular stress plausibly reproduces the development of epidermal cell shape. Together, our results suggest that mechanical stress is a key driver of cell-shape morphogenesis. © 2018, Sapala et al.

  11. The orthopositronium lifetime puzzle and its final solution

    International Nuclear Information System (INIS)

    Liu Feng; Wu Jianda; Zhan Liang; Ye Bangjiao

    2004-01-01

    The ortho-positronium (o-Ps), which consists of an electron and positron, is a pure lepton bound system. The o-Ps lifetime can be calculated accurately by quantum electrodynamics, but there is a long-standing discrepancy between the theoretical calculations and the experimental results. Theoretical and experimental physicists have worked hard for a long time to solve the problem, and recently finally solved this lifetime puzzle. The authors briefly outline the discrepancy between the theoretical calculations of the o-Ps annihilation decay rate and some of the experimental measurements, as well as recent developments of experimental techniques, and its final solution. In particular, the final results of the Tokyo and michigan groups are discussed

  12. Gaia's view of the λ Boo star puzzle

    Science.gov (United States)

    Murphy, Simon J.; Paunzen, Ernst

    2017-04-01

    The evolutionary status of the chemically peculiar class of λ Boo stars has been intensely debated. It is now agreed that the λ Boo phenomenon affects A stars of all ages, from star formation to the terminal age main sequence, but the cause of the chemical peculiarity is still a puzzle. We revisit the debate of their ages and temperatures in order to shed light on the phenomenon, using the new parallaxes in Gaia Data Release 1 with existing Hipparcos parallaxes and multicolour photometry. We find that no single formation mechanism is able to explain all the observations, and suggest that there are multiple channels producing λ Boo spectra. The relative importance of these channels varies with age, temperature and environment.

  13. 200 more puzzling physics problems with hints and solutions

    CERN Document Server

    Gnädig, Péter; Vigh, Máté

    2016-01-01

    Like its predecessor, 200 Puzzling Physics Problems, this book is aimed at strengthening students' grasp of the laws of physics by applying them to situations that are practical, and to problems that yield more easily to intuitive insight than to brute-force methods and complex mathematics. The problems are chosen almost exclusively from classical, non-quantum physics, but are no easier for that. They are intriguingly posed in accessible non-technical language, and require readers to select an appropriate analysis framework and decide which branches of physics are involved. The general level of sophistication needed is that of the exceptional school student, the good undergraduate, or the competent graduate student; some physics professors may find some of the more difficult questions challenging. By contrast, the mathematical demands are relatively minimal, and seldom go beyond elementary calculus. This further book of physics problems is not only instructive and challenging, but also enjoyable.

  14. Lambda-nuclear interactions and hyperon puzzle in neutron stars

    Energy Technology Data Exchange (ETDEWEB)

    Haidenbauer, J. [Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik and Juelich Center for Hadron Physics, Juelich (Germany); Universitaet Bonn, Helmholtz Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics, Bonn (Germany); Meissner, U.G. [Universitaet Bonn, Helmholtz Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics, Bonn (Germany); Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik and Juelich Center for Hadron Physics, Juelich (Germany); Kaiser, N.; Weise, W. [Technische Universitaet Muenchen, Physik Department, Garching (Germany)

    2017-06-15

    Brueckner theory is used to investigate the in-medium properties of a Λ-hyperon in nuclear and neutron matter, based on hyperon-nucleon interactions derived within SU(3) chiral effective field theory (EFT). It is shown that the resulting Λ single-particle potential U{sub Λ}(p{sub Λ} = 0, ρ) becomes strongly repulsive for densities ρ of two-to-three times that of normal nuclear matter. Adding a density-dependent effective ΛN-interaction constructed from chiral ΛNN three-body forces increases the repulsion further. Consequences of these findings for neutron stars are discussed. It is argued that for hyperon-nuclear interactions with properties such as those deduced from the SU(3) EFT potentials, the onset for hyperon formation in the core of neutron stars could be shifted to much higher density which, in turn, could pave the way for resolving the so-called hyperon puzzle. (orig.)

  15. Clarifying some remaining questions in the anomaly puzzle

    International Nuclear Information System (INIS)

    Huang, Xing; Parker, Leonard

    2011-01-01

    We discuss several points that may help to clarify some questions that remain about the anomaly puzzle in supersymmetric theories. In particular, we consider a general N=1 supersymmetric Yang-Mills theory. The anomaly puzzle concerns the question of whether there is a consistent way in the quantized theory to put the R-current and the stress tensor in a single supermultiplet called the supercurrent, even though in the classical theory they are in the same supermultiplet. It was proposed that the classically conserved supercurrent bifurcates into two supercurrents having different anomalies in the quantum regime. The most interesting result we obtain is an explicit expression for the lowest component of one of the two supercurrents in 4-dimensional spacetime, namely the supercurrent that has the energy-momentum tensor as one of its components. This expression for the lowest component is an energy-dependent linear combination of two chiral currents, which itself does not correspond to a classically conserved chiral current. The lowest component of the other supercurrent, namely, the R-current, satisfies the Adler-Bardeen theorem. The lowest component of the first supercurrent has an anomaly, which we show is consistent with the anomaly of the trace of the energy-momentum tensor. Therefore, we conclude that there is no consistent way to construct a single supercurrent multiplet that contains the R-current and the stress tensor in the straightforward way originally proposed. We also discuss and try to clarify some technical points in the derivations of the two supercurrents in the literature. These latter points concern the significance of infrared contributions to the NSVZ β-function and the role of the equations of motion in deriving the two supercurrents. (orig.)

  16. Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students--a pilot study.

    Science.gov (United States)

    Rubinstein, Jack; Dhoble, Abhijeet; Ferenchick, Gary

    2009-01-13

    Most medical professionals are expected to possess basic electrocardiogram (EKG) interpretation skills. But, published data suggests that residents' and physicians' EKG interpretation skills are suboptimal. Learning styles differ among medical students; individualization of teaching methods has been shown to be viable and may result in improved learning. Puzzles have been shown to facilitate learning in a relaxed environment. The objective of this study was to assess efficacy of teaching puzzle in EKG interpretation skills among medical students. This is a reader blinded crossover trial. Third year medical students from College of Human Medicine, Michigan State University participated in this study. Two groups (n = 9) received two traditional EKG interpretation skills lectures followed by a standardized exam and two extra sessions with the teaching puzzle and a different exam. Two other groups (n = 6) received identical courses and exams with the puzzle session first followed by the traditional teaching. EKG interpretation scores on final test were used as main outcome measure. The average score after only traditional teaching was 4.07 +/- 2.08 while after only the puzzle session was 4.04 +/- 2.36 (p = 0.97). The average improvement after the traditional session was followed up with a puzzle session was 2.53 +/- 1.94 while the average improvement after the puzzle session was followed with the traditional session was 2.08 +/- 1.73 (p = 0.67). The final EKG exam score for this cohort (n = 15) was 84.1 compared to 86.6 (p = 0.22) for a comparable sample of medical students (n = 15) at a different campus. Teaching EKG interpretation with puzzles is comparable to traditional teaching and may be particularly useful for certain subgroups of students. Puzzle session are more interactive and relaxing, and warrant further investigations on larger scale.

  17. Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students – a pilot study

    Science.gov (United States)

    Rubinstein, Jack; Dhoble, Abhijeet; Ferenchick, Gary

    2009-01-01

    Background Most medical professionals are expected to possess basic electrocardiogram (EKG) interpretation skills. But, published data suggests that residents' and physicians' EKG interpretation skills are suboptimal. Learning styles differ among medical students; individualization of teaching methods has been shown to be viable and may result in improved learning. Puzzles have been shown to facilitate learning in a relaxed environment. The objective of this study was to assess efficacy of teaching puzzle in EKG interpretation skills among medical students. Methods This is a reader blinded crossover trial. Third year medical students from College of Human Medicine, Michigan State University participated in this study. Two groups (n = 9) received two traditional EKG interpretation skills lectures followed by a standardized exam and two extra sessions with the teaching puzzle and a different exam. Two other groups (n = 6) received identical courses and exams with the puzzle session first followed by the traditional teaching. EKG interpretation scores on final test were used as main outcome measure. Results The average score after only traditional teaching was 4.07 ± 2.08 while after only the puzzle session was 4.04 ± 2.36 (p = 0.97). The average improvement after the traditional session was followed up with a puzzle session was 2.53 ± 1.94 while the average improvement after the puzzle session was followed with the traditional session was 2.08 ± 1.73 (p = 0.67). The final EKG exam score for this cohort (n = 15) was 84.1 compared to 86.6 (p = 0.22) for a comparable sample of medical students (n = 15) at a different campus. Conclusion Teaching EKG interpretation with puzzles is comparable to traditional teaching and may be particularly useful for certain subgroups of students. Puzzle session are more interactive and relaxing, and warrant further investigations on larger scale. PMID:19144134

  18. Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students – a pilot study

    Directory of Open Access Journals (Sweden)

    Dhoble Abhijeet

    2009-01-01

    Full Text Available Abstract Background Most medical professionals are expected to possess basic electrocardiogram (EKG interpretation skills. But, published data suggests that residents' and physicians' EKG interpretation skills are suboptimal. Learning styles differ among medical students; individualization of teaching methods has been shown to be viable and may result in improved learning. Puzzles have been shown to facilitate learning in a relaxed environment. The objective of this study was to assess efficacy of teaching puzzle in EKG interpretation skills among medical students. Methods This is a reader blinded crossover trial. Third year medical students from College of Human Medicine, Michigan State University participated in this study. Two groups (n = 9 received two traditional EKG interpretation skills lectures followed by a standardized exam and two extra sessions with the teaching puzzle and a different exam. Two other groups (n = 6 received identical courses and exams with the puzzle session first followed by the traditional teaching. EKG interpretation scores on final test were used as main outcome measure. Results The average score after only traditional teaching was 4.07 ± 2.08 while after only the puzzle session was 4.04 ± 2.36 (p = 0.97. The average improvement after the traditional session was followed up with a puzzle session was 2.53 ± 1.94 while the average improvement after the puzzle session was followed with the traditional session was 2.08 ± 1.73 (p = 0.67. The final EKG exam score for this cohort (n = 15 was 84.1 compared to 86.6 (p = 0.22 for a comparable sample of medical students (n = 15 at a different campus. Conclusion Teaching EKG interpretation with puzzles is comparable to traditional teaching and may be particularly useful for certain subgroups of students. Puzzle session are more interactive and relaxing, and warrant further investigations on larger scale.

  19. The impact of memory load and perceptual cues on puzzle learning by 24-month olds.

    Science.gov (United States)

    Barr, Rachel; Moser, Alecia; Rusnak, Sylvia; Zimmermann, Laura; Dickerson, Kelly; Lee, Herietta; Gerhardstein, Peter

    2016-11-01

    Early childhood is characterized by memory capacity limitations and rapid perceptual and motor development [Rovee-Collier (1996). Infant Behavior & Development, 19, 385-400]. The present study examined 2-year olds' reproduction of a sliding action to complete an abstract fish puzzle under different levels of memory load and perceptual feature support. Experimental groups were compared to baseline controls to assess spontaneous rates of production of the target actions; baseline production was low across all experiments. Memory load was manipulated in Exp. 1 by adding pieces to the puzzle, increasing sequence length from 2 to 3 items, and to 3 items plus a distractor. Although memory load did not influence how toddlers learned to manipulate the puzzle pieces, it did influence toddlers' achievement of the goal-constructing the fish. Overall, girls were better at constructing the puzzle than boys. In Exp. 2, the perceptual features of the puzzle were altered by changing shape boundaries to create a two-piece horizontally cut puzzle (displaying bilateral symmetry), and by adding a semantically supportive context to the vertically cut puzzle (iconic). Toddlers were able to achieve the goal of building the fish equally well across the 2-item puzzle types (bilateral symmetry, vertical, iconic), but how they learned to manipulate the puzzle pieces varied as a function of the perceptual features. Here, as in Exp. 1, girls showed a different pattern of performance from the boys. This study demonstrates that changes in memory capacity and perceptual processing influence both goal-directed imitation learning and motoric performance. © 2016 Wiley Periodicals, Inc.

  20. A Resolution of the Purchasing Power Parity Puzzle: Imperfect Knowledge and Long Swings

    DEFF Research Database (Denmark)

    Frydman, Roman; Goldberg, Michael D.; Johansen, Søren

    2009-01-01

    Asset prices undergo long swings that revolve around benchmark levels. In currency markets, fluctuations involve real exchange rates that are highly persistent and that move in near-parallel fashion with nominal rates. The inability to explain these two regularities with one model has been called...... the "purchasing power parity puzzle." In this paper, we trace the puzzle to exchange rate modelers' use of the "Rational Expectations Hypothesis." We show that once imperfect knowledge is recognized, a monetary model is able to account for the puzzle, as well as other salient features of the data, including...

  1. The 20th anniversary of the three-nucleon analyzing power puzzle - a personal recollection

    International Nuclear Information System (INIS)

    Tornow, W. . Author

    2008-01-01

    The history of the three-nucleon analyzing power puzzle is described by an experimentalist who has been collaborating with few-body theoreticians in trying to unravel the physics of this long-standing phenomenon. Although surprising effects have been discovered along the way, the puzzle is still unexplained. Hopefully, some of the long-range three-nucleon force terms predicted by chiral effective field theory in N 3 LO will eventually solve the puzzle. Presented at the 20th Few-Body Conference, Pisa, Italy, 10-14 September 2007. (author)

  2. The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

    Science.gov (United States)

    O'Connor, Angela M.; Burton, Thomas J.; Leamey, Catherine A.; Sawatari, Atomu

    2014-01-01

    Environmental enrichment can dramatically influence the development and function of neural circuits. Further, enrichment has been shown to successfully delay the onset of symptoms in models of Huntington’s disease 1-4, suggesting environmental factors can evoke a neuroprotective effect against the progressive, cellular level damage observed in neurodegenerative disorders. The ways in which an animal can be environmentally enriched, however, can vary considerably. Further, there is no straightforward manner in which the effects of environmental enrichment can be assessed: most methods require either fairly complicated behavioral paradigms and/or postmortem anatomical/physiological analyses. This protocol describes the use of a simple and inexpensive behavioral assay, the Puzzle Box 5-7 as a robust means of determining the efficacy of increased social, sensory and motor stimulation on mice compared to cohorts raised in standard laboratory conditions. This simple problem solving task takes advantage of a rodent’s innate desire to avoid open enclosures by seeking shelter. Cognitive ability is assessed by adding increasingly complex impediments to the shelter’s entrance. The time a given subject takes to successfully remove the obstructions and enter the shelter serves as the primary metric for task performance. This method could provide a reliable means of rapidly assessing the efficacy of different enrichment protocols on cognitive function, thus paving the way for systematically determining the role specific environmental factors play in delaying the onset of neurodevelopmental and neurodegenerative disease. PMID:25590345

  3. Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.

    Science.gov (United States)

    Rutsch, Frank; Nitschke, Yvonne; Terkeltaub, Robert

    2011-08-19

    Artery calcification reflects an admixture of factors such as ectopic osteochondral differentiation with primary host pathological conditions. We review how genetic factors, as identified by human genome-wide association studies, and incomplete correlations with various mouse studies, including knockout and strain analyses, fit into "pieces of the puzzle" in intimal calcification in human atherosclerosis, and artery tunica media calcification in aging, diabetes mellitus, and chronic kidney disease. We also describe in sharp contrast how ENPP1, CD73, and ABCC6 serve as "cogs in a wheel" of arterial calcification. Specifically, each is a minor component in the function of a much larger network of factors that exert balanced effects to promote and suppress arterial calcification. For the network to normally suppress spontaneous arterial calcification, the "cogs" ENPP1, CD73, and ABCC6 must be present and in working order. Monogenic ENPP1, CD73, and ABCC6 deficiencies each drive a molecular pathophysiology of closely related but phenotypically different diseases (generalized arterial calcification of infancy (GACI), pseudoxanthoma elasticum (PXE) and arterial calcification caused by CD73 deficiency (ACDC)), in which premature onset arterial calcification is a prominent but not the sole feature.

  4. Family caregivers of palliative cancer patients at home: the puzzle of pain management.

    Science.gov (United States)

    Mehta, Anita; Cohen, S Robin; Carnevale, Franco A; Ezer, Hélène; Ducharme, Francine

    2010-01-01

    The purpose of this grounded theory study was to understand the processes used by family caregivers to manage the pain of cancer patients at home. A total of 24 family caregivers participated. They were recruited using purposeful then theoretical sampling. The data sources were taped, transcribed (semi-structured) interviews and field notes. Data analysis was based on Strauss and Corbin's (1998) requirements for open, axial, and selective coding. The result was an explanatory model titled "the puzzle of pain management," which includes four main processes: "drawing on past experiences"; "strategizing a game plan"; "striving to respond to pain"; and "gauging the best fit," a decision-making process that joins the puzzle pieces. Understanding how family caregivers assemble their puzzle pieces can help health care professionals make decisions related to the care plans they create for pain control and help them to recognize the importance of providing information as part of resolving the puzzle of pain management.

  5. The Retrofit Puzzle Extended: Optimal Fleet Owner Behavior over Multiple Time Periods

    Science.gov (United States)

    2009-08-04

    In "The Retrofit Puzzle: Optimal Fleet Owner Behavior in the Context of Diesel Retrofit Incentive Programs" (1) an integer program was developed to model profit-maximizing diesel fleet owner behavior when selecting pollution reduction retrofits. Flee...

  6. Well-Defined Cyclic Triblock Terpolymers: A Missing Piece of the Morphology Puzzle

    KAUST Repository

    Polymeropoulos, George; Bilalis, Panayiotis; Hadjichristidis, Nikolaos

    2016-01-01

    Two well-defined cyclic triblock terpolymers, missing pieces of the terpolymer morphology puzzle, consisting of poly(isoprene), polystyrene, and poly(2-vinylpyridine), were synthesized by combining the Glaser coupling reaction with anionic

  7. A Play on Words: Using Cognitive Computing as a Basis for AI Solvers in Word Puzzles

    Science.gov (United States)

    Manzini, Thomas; Ellis, Simon; Hendler, James

    2015-12-01

    In this paper we offer a model, drawing inspiration from human cognition and based upon the pipeline developed for IBM's Watson, which solves clues in a type of word puzzle called syllacrostics. We briefly discuss its situation with respect to the greater field of artificial general intelligence (AGI) and how this process and model might be applied to other types of word puzzles. We present an overview of a system that has been developed to solve syllacrostics.

  8. The Forward-Bias Puzzle: A Solution Based on Covered Interest Parity

    OpenAIRE

    Pippenger, John

    2009-01-01

    The forward-bias puzzle is probably the most important puzzle in international macroeconomics. After more than 20 years, there is no accepted solution. My solution is based on covered interest parity (CIP). CIP implies: (1) Forward rates are not rational expectations of future spot rates. Those expectations depend on future spot rates and interest rate differentials. (2) The forward bias is the result of a specification error, replacing future forward exchange rates with current forward ...

  9. The π+-emission puzzle in 4ΛHe decay

    International Nuclear Information System (INIS)

    Gibson, B.F.; Timmermans, R.G.E.

    1998-01-01

    We re-examine the puzzling π + emission from the weak decay of 4 Λ He and propose an explanation in terms of a three-body decay of the virtual Σ + . Such a resolution of the π + decay puzzle is consistent with the calculated Σ + probability in light Λ hypernuclei as well as the experimentally observed π + energy spectrum and s-wave angular distribution. (orig.)

  10. A Hierarchical Interface Design of a Puzzle Game for Elementary Education

    OpenAIRE

    Eun-Young Park; Young-Ho Park

    2010-01-01

    A basic instinct of humans for perfect completion usually drives us happy. Basically, humans purchase a certain complete match for scattered facts. The satisfaction of completing the scattered pieces gives us great pleasure. Thus many people put in their time and effort in the puzzle, and they gain strong satisfaction. The paper solves the importance of the general effects of a puzzle in building the edu-game design. Legacy online education has following problems. First, educational effects b...

  11. JIGSAW PUZZLE IMPROVE FINE MOTOR ABILITIES OF UPPER EXTREMITIES IN POST-STROKE ISCHEMIC CLIENTS

    Directory of Open Access Journals (Sweden)

    Kusnanto Kusnanto

    2017-06-01

    Full Text Available Introduction: Ischemic stroke is a disease caused by focal cerebral ischemia, where is a decline in blood flow that needed for neuronal metabolism, leading to neurologic deficit include motor deficit such as fine motor skills impairment. Therapy of fine motor skills disorders is to improve motor function, prevent contractures and complications. These study aimed to identify the effect of playing Jigsaw Puzzle on muscle strength, extensive motion, and upper extremity fine motor skills in patients with ischemic stroke at Dr. Moewardi Hospital, Surakarta. Methods: Experimental Quasi pre-posttest one group control. The number of samples were 34 respondents selected using purposive sampling technique. The samples were divided into intervention and control groups. The intervention group was 17 respondents who were given standard treatment hospital and played Jigsaw Puzzle 2 times a day for six days. Control group is one respondent given by hospital standard therapy without given additional Jigsaw Puzzle game. Evaluation of these research is done on the first and seventh day for those groups. Result: The results showed that muscle strength, the range of joint motion and fine motor skills of upper extremities increased (p = 0.001 significantly after being given the Jigsaw Puzzle games. These means playing Jigsaw Puzzle increase muscle strength, the range of joint motion and upper extremity fine motor skill of ischemic stroke patients. Discussion and conclusion: Jigsaw puzzle game administration as additional rehabilitation therapy in upper extremity fine motor to minimize the occurrence of contractures and motor disorders in patients with ischemic stroke. Jigsaw puzzle game therapy capable of creating repetitive motion as a key of neurological rehabilitation in Ischemic Stroke. This study recommends using jigsaw puzzle game as one of intervention in the nursing care of Ischemic Stroke patients.

  12. Association of Crossword Puzzle Participation with Memory Decline in Persons Who Develop Dementia

    Science.gov (United States)

    Pillai, Jagan A.; Hall, Charles B.; Dickson, Dennis W.; Buschke, Herman; Lipton, Richard B.; Verghese, Joe

    2013-01-01

    Participation in cognitively stimulating leisure activities such as crossword puzzles may delay onset of the memory decline in the preclinical stages of dementia, possibly via its effect on improving cognitive reserve. We followed 488 initially cognitively intact community residing individuals with clinical and cognitive assessments every 12–18 months in the Bronx Aging Study. We assessed the influence of crossword puzzle participation on the onset of accelerated memory decline as measured by the Buschke Selective Reminding Test in 101 individuals who developed incident dementia using a change point model. Crossword puzzle participation at baseline delayed onset of accelerated memory decline by 2.54 years. Inclusion of education or participation in other cognitively stimulating activities did not significantly add to the fit of the model beyond the effect of puzzles. Our findings show that late life crossword puzzle participation, independent of education, was associated with delayed onset of memory decline in persons who developed dementia. Given the wide availability and accessibility of crossword puzzles, their role in preventing cognitive decline should be validated in future clinical trials. PMID:22040899

  13. PENERAPAN JIGSAW PUZZLE COMPETITION DALAM PEMBELAJARAN KONTEKSTUAL UNTUK MENINGKATKAN MINAT DAN HASIL BELAJAR FISIKA SISWA SMP

    Directory of Open Access Journals (Sweden)

    D. Yulianti

    2012-01-01

    Full Text Available Untuk mengatasi kurangnya minat dan hasil belajar fisika siswa dilakukan penelitian melalui kegiatan pembelajaran fisikakontekstual berbantuan jigsaw puzzle competititon. Subjek penelitian ini adalah siswa kelas VII H SMP Negeri 18 Semarang.Penelitian ini telah dilakukan pembelajaran dengan pendekatan kontekstual berbantuan jigsaw puzzle competition. Hasilpenelitian menunjukkan bahwa pembelajaran kontekstual berbantuan jigsaw puzzle competition mampu meningkatan minat danhasil belajar siswa kelas VII H SMPNegeri 18 Semarang tahun pelajaran 2008/2009 secara signifikan. Agar lebih efektif sebaiknyadikembangkan pembelajaran kontekstual dengan metode lain agar diperoleh peningkatan minat dan hasil belajar Model ini perludiaplikasikan dalam pembelajaran fisika untuk materi yang lain. To overcome the problem of lack of students' interest as well as their achievements a Jigsaw Puzzle Competition in physicscontextual learning process was done. The students from VIIHclass of Junior High School 18 Semarang academic year 2008/2009were chosen as the subjects. The result of this research shows that contextual teaching and learning using Jigsaw PuzzleCompetition approach was not only increase the students' interest but also improve their achievements. In order to get moreeffective result, it is necessary to develop contextual teaching and learning by combining them with other method. Because of thegreat benefit of this model, it is necessary to apply this model to other physics learning concepts.Keywords: Jigsaw Puzzle Competition, contextual, interest;

  14. Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle

    Science.gov (United States)

    Kaddar, Tagrid; Carreau, Madeleine

    2012-01-01

    In recent years, Fanconi anemia (FA) has been the subject of intense investigations, primarily in the DNA repair research field. Many discoveries have led to the notion of a canonical pathway, termed the FA pathway, where all FA proteins function sequentially in different protein complexes to repair DNA cross-link damages. Although a detailed architecture of this DNA cross-link repair pathway is emerging, the question of how a defective DNA cross-link repair process translates into the disease phenotype is unresolved. Other areas of research including oxidative metabolism, cell cycle progression, apoptosis, and transcriptional regulation have been studied in the context of FA, and some of these areas were investigated before the fervent enthusiasm in the DNA repair field. These other molecular mechanisms may also play an important role in the pathogenesis of this disease. In addition, several FA-interacting proteins have been identified with roles in these “other” nonrepair molecular functions. Thus, the goal of this paper is to revisit old ideas and to discuss protein-protein interactions related to other FA-related molecular functions to try to give the reader a wider perspective of the FA molecular puzzle. PMID:22737580

  15. Hyperon puzzle of neutron stars with Skyrme force models

    International Nuclear Information System (INIS)

    Lim, Yeunhwan; Hyun, Chang Ho; Kwak, Kyujin; Lee, Chang-Hwan

    2015-01-01

    We consider the so-called hyperon puzzle of neutron star (NS). We employ Skyrme force models for the description of in-medium nucleon–nucleon (NN), nucleon–Lambda hyperon (NΛ) and Lambda–Lambda (ΛΛ) interactions. A phenomenological finite-range force (FRF) for the ΛΛ interaction is considered as well. Equation of state (EoS) of NS matter is obtained in the framework of density functional theory, and Tolman–Oppenheimer–Volkoff (TOV) equations are solved to obtain the mass-radius relations of NSs. It has been generally known that the existence of hyperons in the NS matter is not well supported by the recent discovery of large-mass NSs (M ≃ 2M⊙) since hyperons make the EoS softer than the one without them. For the selected interaction models, NΛ interactions reduce the maximum mass of NS by about 30%, while ΛΛ interactions can give about 10% enhancement. Consequently, we find that some Skyrme force models predict the maximum mass of NS consistent with the observation of 2M ⊙ NSs, and at the same time satisfy observationally constrained mass-radius relations. (author)

  16. Cohabitants' perspective on housing adaptations: a piece of the puzzle.

    Science.gov (United States)

    Granbom, Marianne; Taei, Afsaneh; Ekstam, Lisa

    2017-12-01

    As part of the Swedish state-funded healthcare system, housing adaptations are used to promote safe and independent living for disabled people in ordinary housing through the elimination of physical environmental barriers in the home. The aim of this study was to describe the cohabitants' expectations and experiences of how a housing adaptation, intended for the partner, would impact their everyday life. In-depth interviews were conducted with cohabitants of nine people applying for a housing adaptation, initially at the time of the application and then again 3 months after the housing adaptation was installed. A longitudinal analysis was performed including analysis procedures from Grounded Theory. The findings revealed the expectations and experiences in four categories: partners' activities and independence; cohabitants' everyday activities and caregiving; couples' shared recreational/leisure activities; and housing decisions. A core category putting the intervention into perspective was called 'Housing adaptations - A piece of the puzzle'. From the cohabitants' perspective, new insights on housing adaptations emerged, which are important to consider when planning and carrying out successful housing adaptations. © 2017 Nordic College of Caring Science.

  17. Puzzling Two-Proton Decay of 67Kr

    Science.gov (United States)

    Wang, S. M.; Nazarewicz, W.

    2018-05-01

    Ground-state two-proton (2 p ) radioactivity is a rare decay mode found in a few very proton-rich isotopes. The 2 p decay lifetime and properties of emitted protons carry invaluable information on nuclear structure in the presence of a low-lying proton continuum. The recently measured 2 p decay of 67Kr turned out to be unexpectedly fast. Since 67Kr is expected to be a deformed system, we investigate the impact of deformation effects on the 2 p radioactivity. We apply the recently developed Gamow coupled-channel framework, which allows for a precise description of three-body systems in the presence of rotational and vibrational couplings. This is the first application of a three-body approach to a two-nucleon decay from a deformed nucleus. We show that deformation couplings significantly increase the 2 p decay width of 67Kr; this finding explains the puzzling experimental data. The calculated angular proton-proton correlations reflect a competition between 1 p and 2 p decay modes in this nucleus.

  18. Induced Hyperon-Nucleon-Nucleon Interactions and the Hyperon Puzzle.

    Science.gov (United States)

    Wirth, Roland; Roth, Robert

    2016-10-28

    We present the first ab initio calculations for p-shell hypernuclei including hyperon-nucleon-nucleon (YNN) contributions induced by a similarity renormalization group transformation of the initial hyperon-nucleon interaction. The transformation including the YNN terms conserves the spectrum of the Hamiltonian while drastically improving model-space convergence of the importance-truncated no-core model, allowing a precise extraction of binding and excitation energies. Results using a hyperon-nucleon interaction at leading order in chiral effective field theory for lower- to mid-p-shell hypernuclei show a good reproduction of experimental excitation energies while hyperon separation energies are typically overestimated. The induced YNN contributions are strongly repulsive and we show that they are related to a decoupling of the Σ hyperons from the hypernuclear system, i.e., a suppression of the Λ-Σ conversion terms in the Hamiltonian. This is linked to the so-called hyperon puzzle in neutron-star physics and provides a basic mechanism for the explanation of strong ΛNN three-baryon forces.

  19. Is the proton radius puzzle evidence of extra dimensions?

    Energy Technology Data Exchange (ETDEWEB)

    Dahia, F.; Lemos, A.S. [Universidade Federal da Paraiba, Department of Physics, Joao Pessoa, PB (Brazil)

    2016-08-15

    The proton charge radius inferred from muonic hydrogen spectroscopy is not compatible with the previous value given by CODATA-2010, which, on its turn, essentially relies on measurements of the electron-proton interaction. The proton's new size was extracted from the 2S-2P Lamb shift in the muonic hydrogen, which showed an energy excess of 0.3 meV in comparison to the theoretical prediction, evaluated with the CODATA radius. Higher-dimensional gravity is a candidate to explain this discrepancy, since the muon-proton gravitational interaction is stronger than the electron-proton interaction and, in the context of braneworld models, the gravitational potential can be hugely amplified in short distances when compared to the Newtonian potential. Motivated by these ideas, we study a muonic hydrogen confined in a thick brane. We show that the muon-proton gravitational interaction modified by extra dimensions can provide the additional separation of 0.3 meV between the 2S and 2P states. In this scenario, the gravitational energy depends on the higher-dimensional Planck mass and indirectly on the brane thickness. Studying the behavior of the gravitational energy with respect to the brane thickness in a realistic range, we find constraints for the fundamental Planck mass that solve the proton radius puzzle and are consistent with previous experimental bounds. (orig.)

  20. Global climate change and the equity-efficiency puzzle

    International Nuclear Information System (INIS)

    Manne, Alan S.; Stephan, Gunter

    2005-01-01

    There is a broad consensus that the costs of abatement of global climate change can be reduced efficiently through the assignment of quota rights and through international trade in these rights. There is, however, no consensus on whether the initial assignment of emissions permits can affect the Pareto-optimal global level of abatement. This paper provides some insight into the equity-efficiency puzzle. Qualitative results are obtained from a small-scale model; then quantitative evidence of separability is obtained from MERGE, a multiregion integrated assessment model. It is shown that if all the costs of climate change can be expressed in terms of GDP losses, Pareto-efficient abatement strategies are independent of the initial allocation of emissions rights. This is the case sometimes described as 'market damages'. If, however, different regions assign different values to nonmarket damages such as species losses, different sharing rules may affect the Pareto-optimal level of greenhouse gas abatement. Separability may then be demonstrated only in specific cases (e.g. identical welfare functions or quasi-linearity of preferences or small shares of wealth devoted to abatement)

  1. Brodmann area 12: an historical puzzle relevant to FTLD.

    Science.gov (United States)

    Kawamura, M; Miller, M W; Ichikawa, H; Ishihara, K; Sugimoto, A

    2011-05-03

    Brodmann brain maps, assembled in 1909, are still in use, but understanding of their animal-human homology is uncertain. Furthermore, in 1909, Brodmann did not identify human area 12 (BA12), a location now important to understanding of frontotemporal lobar degeneration (FTLD). We re-examined Brodmann's areas, both animal and human, in his 1909 monograph and other literature, both historical and contemporary, and projected BA12 onto the medial surface of a fixed human brain to show its location. We found Brodmann did identify human BA12 in later maps (1910 and 1914), but that his brain areas, contrary to his own aims as a comparative anatomist, are now used as physiologic loci in human brain. Because of its current link with frontotemporal dementia, BA12's transition from animal (1909) to human (1910 and 1914) is not only an historical puzzle. It impacts how Brodmann's areas, based on comparative animal-human cytoarchitecture, are widely used in current research as functional loci in human brain.

  2. Induced hyperon-nucleon-nucleon interactions and the hyperon puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Wirth, Roland; Roth, Robert [Institut fuer Kernphysik, TU Darmstadt (Germany)

    2016-07-01

    There is a strong experimental and theoretical interest in determining the structure of hypernuclei and the effect of strangeness in strongly interacting many-body systems. Recently, we presented the first calculations of hypernuclei in the p shell from first principles. However, these calculations showed either slow convergence with respect to model-space size or, when the hyperon-nucleon potential is transformed via the Similarity Renormalization Group, strong induced three-body terms. By including these induced hyperon-nucleon-nucleon (YNN) terms explicitly, we get precise binding and excitation energies. We present first results for p-shell hypernuclei and discuss the origin of the YNN terms, which are mainly driven by the evolution of the Λ-Σ conversion terms. We find that they are tightly connected to the hyperon puzzle, a long-standing issue where the appearance of hyperons in models of neutron star matter lowers the predicted maximum neutron star mass below the bound set by the heaviest observed objects.

  3. METODE BERMAIN PUZZLE BERPENGARUH PADA PERKEMBANGAN MOTORIK HALUS ANAK USIA PRASEKOLAH

    Directory of Open Access Journals (Sweden)

    Lilis Maghfuroh

    2018-03-01

    Full Text Available Pre-school is a period to increase fine motor development of children. This research aims to determine the increasing of fine motor development using the puzzle for preschoolers. his research is using one-group pre-post test design without control and procedures for statistical analysis through Wilcoxon Sign Rank Test with a confidence level of 95% and α: 5%. The subjects of this study were 40 children. The results of the analysis showed that there was effect of the intervention method by playing puzzle through the development of fine motor skills at pre-school children in mind that the value of Z sign p = 0.001 where significant value of p <0.05. Puzzle play method can improve child language development. The results of this research can be used as the basic for doing the puzzles therapy in children because it can improve fine motor skills development of children. Masa prasekolah merupakan masa peningkatan perkembangan motorik halus. Motorik halus adalah gerakan yang dilakukan oleh sekelompok otot-otot kecil seperti jari-jemari. Pada survey awal hampir sebagian anak mengalami perkembangan motorik suspek. Penelitian ini untuk mengetahui pengaruh metode puzzle terhadap perkembangan motorik halus anak pra sekolah. Penelitian ini menggunakan one-group pra-post test design tanpa control dan analisis statistik menggunakan Uji Wilcoxon Sign Rank Test dengan tingkat  kepercayaan 95% dan α : 5%. Populasi penelitian 50 anak dan sample 40 anak dengan tehnik Simple Random Sampling. Setelah data terkumpul dengan menggunakan DDST selanjutnya dianalisa. Hasil penelitian ini menunjukkan ada pengaruh metode bermain puzzle terhadap perkembangan motorik halus diketahui p sign = 0,001 dimana nilai signifikan p < 0,05. Hasil penelitian ini dapat dijadikan dasar untuk melakukan terapi puzzle pada anak untuk meningkatkan perkembangan motorik halus anak.

  4. Electron-muon puzzle and the electromagnetic coupling constant

    International Nuclear Information System (INIS)

    Jehle, H.

    1977-01-01

    On the basis of a heuristic model we argued in an earlier paper (paper C of this series) electric field (and of course the magnetic field, too) of a lepton or of a quark may be formulated in terms of a closed loop of quantized magnetic flux whose alternative forms (''loopforms'') are superposed with probability amplitudes so as to represent the electromagnetic field of that lepton or quark. The Zitterbewegung of a single stationary (''elementary'') particle suggests a kind of quasiextension, which is assumed, in the present theory, to permit concepts of structuralization of the electromagnetic field even for leptons. Mesons and baryons may be represented by linked quantized flux loops, i.e., quark loops (as in paper B). The central problem now (in this paper D) is to formulate those probability-amplitude distributions in terms of wave functions to characterize the internal structure of the lepton or quark in question. As probability-amplitude functions one may choose bases of irreducible representations of the group with respect to which the model is to be invariant. It is seen that this implies the SO(4) group. As both the electron-muon mass ratio and the electromagnetic coupling constant depend, in this flux-quantization model, on the correct formulation of the structuralization of probability-amplitude distributions, we should expect to get an insight into both these puzzles from finding the right probability-amplitude wave functions. Furthermore, it is seen that this same structuralization of probability-amplitude distributions also permits one to estimate the rate of weak interactions, thus relating them to electromagnetic interactions

  5. HIV in Japan: Epidemiologic puzzles and ethnographic explanations

    Directory of Open Access Journals (Sweden)

    Anthony S. DiStefano

    2016-12-01

    Full Text Available Japan is widely perceived to have a low level of HIV occurrence; however, its HIV epidemics also have been the subject of considerable misunderstanding globally. I used a ground truthing conceptual framework to meet two aims: first, to determine how accurately official surveillance data represented Japan's two largest epidemics (urban Kansai and Tokyo as understood and experienced on the ground; and second, to identify explanations for why the HIV epidemics were unfolding as officially reported. I used primarily ethnographic methods while drawing upon epidemiology, and compared government surveillance data to observations at community and institutional sites (459 pages of field notes; 175 persons observed, qualitative interviews with stakeholders in local HIV epidemics (n = 32, and document research (n = 116. This revealed seven epidemiologic puzzles involving officially reported trends and conspicuously missing information. Ethnographically grounded explanations are presented for each. These included factors driving the epidemics, which ranged from waning government and public attention to HIV, to gaps in sex education and disruptive leadership changes in public institutions approximately every two years. Factors constraining the epidemics also contributed to explanations. These ranged from subsidized medical treatment for most people living with HIV, to strong partnerships between government and a well-developed, non-governmental sector of HIV interventionists, and protective norms and built environments in the sex industry. Local and regional HIV epidemics were experienced and understood as worse than government reports indicated, and ground-level data often contradicted official knowledge. Results thus call into question epidemiologic trends, including recent stabilization of the national epidemic, and suggest the need for revisions to the surveillance system and strategies that address factors driving and constraining the epidemics. Based

  6. Hyperon puzzle, hadron-quark crossover and massive neutron stars

    International Nuclear Information System (INIS)

    Masuda, Kota; Hatsuda, Tetsuo; Takatsuka, Tatsuyuki

    2016-01-01

    Bulk properties of cold and hot neutron stars are studied on the basis of the hadron-quark crossover picture where a smooth transition from the hadronic phase to the quark phase takes place at finite baryon density. By using a phenomenological equation of state (EOS) ''CRover'', which interpolates the two phases at around 3 times the nuclear matter density (ρ 0 ), it is found that the cold NSs with the gravitational mass larger than 2M CircleDot can be sustained. This is in sharp contrast to the case of the first-order hadron-quark transition. The radii of the cold NSs with the CRover EOS are in the narrow range (12.5 ± 0.5) km which is insensitive to the NS masses. Due to the stiffening of the EOS induced by the hadron-quark crossover, the central density of the NSs is at most 4 ρ 0 and the hyperon-mixing barely occurs inside the NS core. This constitutes a solution of the long-standing hyperon puzzle. The effect of color superconductivity (CSC) on the NS structures is also examined with the hadron-quark crossover. For the typical strength of the diquark attraction, a slight softening of the EOS due to two-flavor CSC (2SC) takes place and the maximum mass is reduced by about 0.2M CircleDot . The CRover EOS is generalized to the supernova matter at finite temperature to describe the hot NSs at birth. The hadron-quark crossover is found to decrease the central temperature of the hot NSs under isentropic condition. The gravitational energy release and the spin-up rate during the contraction from the hot NS to the cold NS are also estimated. (orig.)

  7. Desiccation tolerance of Sphagnum revisited: a puzzle resolved.

    Science.gov (United States)

    Hájek, T; Vicherová, E

    2014-07-01

    As ecosystem engineers, Sphagnum mosses control their surroundings through water retention, acidification and peat accumulation. Because water retention avoids desiccation, sphagna are generally intolerant to drought; however, the literature on Sphagnum desiccation tolerance (DT) provides puzzling results, indicating the inducible nature of their DT. To test this, various Sphagnum species and other mesic bryophytes were hardened to drought by (i) slow drying; (ii) ABA application and (iii) chilling or frost. DT tolerance was assessed as recovery of chlorophyll fluorescence parameters after severe desiccation. We monitored the seasonal course of DT in bog bryophytes. Under laboratory conditions, following initial de-hardening, untreated Sphagnum shoots lacked DT; however, DT was induced by all hardening treatments except chilling, notably by slow drying, and in Sphagnum species of the section Cuspidata. In the field, sphagna in hollows and lawns developed DT several times during the growing season, responding to reduced precipitation and a lowered water table. Hummock and aquatic species developed DT only in late autumn, probably as a response to frost. Sphagnum protonemata failed to develop DT; hence, desiccation may limit Sphagnum establishment in drier habitats with suitable substrate chemistry. Desiccation avoiders among sphagna form compact hummocks or live submerged; thus, they do not develop DT in the field, lacking the initial desiccation experience, which is frequent in hollow and lawn habitats. We confirmed the morpho-physiological trade-off: in contrast to typical hollow sphagna, hummock species invest more resources in water retention (desiccation avoidance), while they have a lower ability to develop physiological DT. © 2013 German Botanical Society and The Royal Botanical Society of the Netherlands.

  8. Hyperon puzzle, hadron-quark crossover and massive neutron stars

    Energy Technology Data Exchange (ETDEWEB)

    Masuda, Kota [The University of Tokyo, Department of Physics, Tokyo (Japan); Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan); Hatsuda, Tetsuo [Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan); The University of Tokyo, Kavli IPMU (WPI), Chiba (Japan); Takatsuka, Tatsuyuki [Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan)

    2016-03-15

    Bulk properties of cold and hot neutron stars are studied on the basis of the hadron-quark crossover picture where a smooth transition from the hadronic phase to the quark phase takes place at finite baryon density. By using a phenomenological equation of state (EOS) ''CRover'', which interpolates the two phases at around 3 times the nuclear matter density (ρ{sub 0}), it is found that the cold NSs with the gravitational mass larger than 2M {sub CircleDot} can be sustained. This is in sharp contrast to the case of the first-order hadron-quark transition. The radii of the cold NSs with the CRover EOS are in the narrow range (12.5 ± 0.5) km which is insensitive to the NS masses. Due to the stiffening of the EOS induced by the hadron-quark crossover, the central density of the NSs is at most 4 ρ{sub 0} and the hyperon-mixing barely occurs inside the NS core. This constitutes a solution of the long-standing hyperon puzzle. The effect of color superconductivity (CSC) on the NS structures is also examined with the hadron-quark crossover. For the typical strength of the diquark attraction, a slight softening of the EOS due to two-flavor CSC (2SC) takes place and the maximum mass is reduced by about 0.2M {sub CircleDot}. The CRover EOS is generalized to the supernova matter at finite temperature to describe the hot NSs at birth. The hadron-quark crossover is found to decrease the central temperature of the hot NSs under isentropic condition. The gravitational energy release and the spin-up rate during the contraction from the hot NS to the cold NS are also estimated. (orig.)

  9. The puzzle of immune phenotypes of childhood asthma.

    Science.gov (United States)

    Landgraf-Rauf, Katja; Anselm, Bettina; Schaub, Bianca

    2016-12-01

    new immunological molecules, the complex puzzle of childhood asthma is still far from being completed. Addressing the current challenges of distinct clinical asthma and wheeze phenotypes, including their stability and underlying endotypes, involves addressing the interplay of innate and adaptive immune regulatory mechanisms in large, interdisciplinary cohorts.

  10. Emergence of Life on Earth: A Physicochemical Jigsaw Puzzle.

    Science.gov (United States)

    Spitzer, Jan

    2017-01-01

    We review physicochemical factors and processes that describe how cellular life can emerge from prebiotic chemical matter; they are: (1) prebiotic Earth is a multicomponent and multiphase reservoir of chemical compounds, to which (2) Earth-Moon rotations deliver two kinds of regular cycling energies: diurnal electromagnetic radiation and seawater tides. (3) Emerging colloidal phases cyclically nucleate and agglomerate in seawater and consolidate as geochemical sediments in tidal zones, creating a matrix of microspaces. (4) Some microspaces persist and retain memory from past cycles, and others re-dissolve and re-disperse back into the Earth's chemical reservoir. (5) Proto-metabolites and proto-biopolymers coevolve with and within persisting microspaces, where (6) Macromolecular crowding and other non-covalent molecular forces govern the evolution of hydrophilic, hydrophobic, and charged molecular surfaces. (7) The matrices of microspaces evolve into proto-biofilms of progenotes with rudimentary but evolving replication, transcription, and translation, enclosed in unstable cell envelopes. (8) Stabilization of cell envelopes 'crystallizes' bacteria-like genetics and metabolism with low horizontal gene transfer-life 'as we know it.' These factors and processes constitute the 'working pieces' of the jigsaw puzzle of life's emergence. They extend the concept of progenotes as the first proto-cellular life, connected backward in time to the cycling chemistries of the Earth-Moon planetary system, and forward to the ancient cell cycle of first bacteria-like organisms. Supra-macromolecular models of 'compartments first' are preferred: they facilitate macromolecular crowding-a key abiotic/biotic transition toward living states. Evolutionary models of metabolism or genetics 'first' could not have evolved in unconfined and uncrowded environments because of the diffusional drift to disorder mandated by the second law of thermodynamics.

  11. KEEFEKTIFAN MODEL PEMBELAJARAN WORD SQUARE BERBANTU MEDIA PUZZLE PADA MATA PELAJARAN IPS SD

    Directory of Open Access Journals (Sweden)

    IBNATUL IZZATI

    2018-01-01

    Full Text Available Abstract                The problems of this research was: how the effectiveness of Word Square learning model supported by Puzzle media to improve learning outcome of Social subject of third grade at Public Elementary School of Wonopringgo 01 (SDN 01 Wonopringgo? The type of this research was True Experiment Design with type of pretest-posttest control group design one kind of treatment. The samples were taken from students of the third grade of A SDN 01 Wonopringgo in the academic year 2016/2017. The data in this study was obtained through tests and documentation. Experimental research on the third grade of A which was given Word Square learning model supported by Puzzle media and the third grade of B was not given Word Square learning model supported by Puzzle media. Posttest results showed that the percentage of posttest grade of the experimental class was 95% of students expressed thoroughly, while the control class is 70%, and based on t test one-party analysis obtained ttest > ttable = 3,100816112> 1.72. Thus, it could be concluded that the learning with Word Square model supported by Puzzle media was effective against student learning outcomes in Social subjects (IPS the third grade at SDN 01 Wonopringgo Pekalongan. Keywords : effectiveness, word square, puzzle

  12. Collecting the Puzzle Pieces: Completing HST's UV+NIR Survey of the TRAPPIST-1 System ahead of JWST

    Science.gov (United States)

    de Wit, Julien

    2017-08-01

    Using the Spitzer Space Telescope, our team has discovered 7 Earth-sized planets around the nearby Ultra-cool dwarf star TRAPPIST-1. These planets are the first to be simultaneously Earth-sized, temperate, and amenable for in-depth atmospheric studies with space-based observatories (notably, JWST). TRAPPIST-1's system thus provides us with the first opportunity to probe the atmospheres of Earth-sized exoplanets and search for signs of habitability beyond our solar system, which will require spectral information from the UV to the IR to complete their atmospheric puzzles.We request 114 HST orbits to complete the UV+NIR survey of the 7 planets in preparation for their in-depth followup with JWST. The suggested low-density of the planets combined with their complex orbital resonance chain indicate that they migrated inward to their current positions and may harbor large water rich reservoir or leftover primordial H2 atmospheres. We have already ruled out the presence of clear H2 atmospheres for the 5 innermost planets using WFC3 and are requesting 16 WFC3 orbits to complete the TRAPPIST-1 NIR reconnaissance survey. Our primary request consists in 98 STIS orbits to complete the survey for extended H-exospheres around each of the planets. H-exospheres are the most accessible observables for volatile reservoirs, which have not been ruled out by our WFC3 observations. Exosphere detection is only amenable using HST unique capabilities in the UV and are pivotal to guide JWST's in-depth followup. The combined information from HST's UV and NIR observations will allow us put the first critical pieces of the atmospheric puzzle in place for these temperate earth-sized worlds.

  13. The puzzling role of CXCR4 in human immunodeficiency virus infection.

    Science.gov (United States)

    Vicenzi, Elisa; Liò, Pietro; Poli, Guido

    2013-01-01

    The human immunodeficiency virus type-1 (HIV-1) is the etiological agent of the acquired immunodeficiency syndrome (AIDS), a disease highly lethal in the absence of combination antiretroviral therapy. HIV infects CD4(+) cells of the immune system (T cells, monocyte-macrophages and dendritic cells) via interaction with a universal primary receptor, the CD4 molecule, followed by a mandatory interaction with a second receptor (co-receptor) belonging to the chemokine receptor family. Apart from some rare cases, two chemokine receptors have been evolutionarily selected to accomplish this need for HIV-1: CCR5 and CXCR4. Yet, usage of these two receptors appears to be neither casual nor simply explained by their levels of cell surface expression. While CCR5 use is the universal rule at the start of every infection regardless of the transmission route (blood-related, sexual or mother to child), CXCR4 utilization emerges later in disease coinciding with the immunological deficient phase of infection. Moreover, in most instances CXCR4 use as viral entry co-receptor is associated with maintenance of CCR5 use. Since antiviral agents preventing CCR5 utilization by the virus are already in use, while others targeting either CCR5 or CXCR4 (or both) are under investigation, understanding the biological correlates of this "asymmetrical" utilization of HIV entry co-receptors bears relevance for the clinical choice of which therapeutics should be administered to infected individuals. We will here summarize the basic knowledge and the hypotheses underlying the puzzling and yet unequivocal role of CXCR4 in HIV-1 infection.

  14. Cryptographic Puzzles and Game Theory against DoS and DDoS attacks in Networks

    DEFF Research Database (Denmark)

    Mikalas, Antonis; Komninos, Nikos; Prasad, Neeli R.

    2008-01-01

    In this chapter, we present techniques to defeat Denial of Service (DoS) and Distributed Denial of Service (DDoS) attacks. In the _rst part, we describe client puzzle techniques that are based on the idea of computationally exhausting a malicious user when he attempts to launch an attack. In the ......In this chapter, we present techniques to defeat Denial of Service (DoS) and Distributed Denial of Service (DDoS) attacks. In the _rst part, we describe client puzzle techniques that are based on the idea of computationally exhausting a malicious user when he attempts to launch an attack....... In the second part we are introducing some basic principles of game theory and we discuss how game theoretical frameworks can protect computer networks. Finally, we show techniques that combine client puzzles with game theory in order to provide DoS and DDoS resilience....

  15. Piecing It Together: The Effect of Background Music on Children's Puzzle Assembly.

    Science.gov (United States)

    Koolidge, Louis; Holmes, Robyn M

    2018-04-01

    This study explored the effects of background music on cognitive (puzzle assembly) task performance in young children. Participants were 87 primarily European-American children (38 boys, 49 girls; mean age = 4.77 years) enrolled in early childhood classes in the northeastern United States. Children were given one minute to complete a 12-piece puzzle task in one of three background music conditions: music with lyrics, music without lyrics, and no music. The music selection was "You're Welcome" from the Disney movie "Moana." Results revealed that children who heard the music without lyrics completed more puzzle pieces than children in either the music with lyrics or no music condition. Background music without distracting lyrics may be beneficial and superior to background music with lyrics for young children's cognitive performance even when they are engaged independently in a nonverbal task.

  16. A puzzling aspect of the effect of advance notice on unemployment

    DEFF Research Database (Denmark)

    Addision, John; Blackburn, McKinley L.

    1995-01-01

    Displaced male workers with generous periods of advance notice tend to move directly into reemployment faster than their non-notified counterparts but once unemployed tend to escape from unemployment much more slowly. We examine three potential explanations for this puzzle associated with unemplo......Displaced male workers with generous periods of advance notice tend to move directly into reemployment faster than their non-notified counterparts but once unemployed tend to escape from unemployment much more slowly. We examine three potential explanations for this puzzle associated...... with unemployment insurance, the endogeneity of notice, and differential search intensity. Of these alternatives, the evidence suggests that it is the additional but less productive search time during the notice interval that creates the appearance of a puzzle....

  17. The DS86 neutron dosimetry enigma: Some missing pieces to the puzzle

    International Nuclear Information System (INIS)

    Gold, R.

    1994-01-01

    International programs have been conducted over the last four decades to quantify the exposure of atom bomb survivors from Hiroshima and Nagasaki. Unfortunately, the quest for accurate gamma-ray and neutron exposure doses of atom bomb survivors has proven illusive. Efforts in the most recent of these programs, designated as Dosimetry System 1986 (DS86), have revealed a serious and persistent discrepancy between neutron transport calculations and thermal neutron activation measurements at the Hiroshima site, which will be called the DS86 neutron dosimetry enigma. It is established that this enigma is a complex puzzle that precludes simple solutions. This conclusion is deduced through the identification of a number of missing pieces to the puzzle. Implications and conclusions that can be inferred from these missing puzzle pieces are advanced

  18. Puzzle Imaging: Using Large-Scale Dimensionality Reduction Algorithms for Localization.

    Science.gov (United States)

    Glaser, Joshua I; Zamft, Bradley M; Church, George M; Kording, Konrad P

    2015-01-01

    Current high-resolution imaging techniques require an intact sample that preserves spatial relationships. We here present a novel approach, "puzzle imaging," that allows imaging a spatially scrambled sample. This technique takes many spatially disordered samples, and then pieces them back together using local properties embedded within the sample. We show that puzzle imaging can efficiently produce high-resolution images using dimensionality reduction algorithms. We demonstrate the theoretical capabilities of puzzle imaging in three biological scenarios, showing that (1) relatively precise 3-dimensional brain imaging is possible; (2) the physical structure of a neural network can often be recovered based only on the neural connectivity matrix; and (3) a chemical map could be reproduced using bacteria with chemosensitive DNA and conjugative transfer. The ability to reconstruct scrambled images promises to enable imaging based on DNA sequencing of homogenized tissue samples.

  19. Penyelesaian Masalah 8-Puzzle dengan Algoritma Steepest-Ascent Hill Climbing

    Directory of Open Access Journals (Sweden)

    David Abraham

    2016-03-01

    Full Text Available 8 puzzle merupakan salah satu implementasi dari Artificial Intelegence. Dalam proses penyelesaiannya banyak terdapat algoritma-algoritma pencarian yang dapat diterapkan. Solusi 8 puzzle akan lebih cepat diperoleh jika digunakan prinsip array dengan variasi algoritma Steepest-Ascent Hill Climbing (Hill Climbing dengan memilih kemiringan yang paling tajam / curam dengan parameter heuristik posisi yang benar dan heuristik jarak serta dikombinasikan dengan LogList sebagai penyimpanan state state yang pernah dilalui untuk menanggulangi permasalah pada algoritma hill climbing itu sendiri dan terhindar dari looping state yang pernah dilalui. Metode-metode yang termasuk ke dalam teknik pencarian yang berdasarkan pada fungsi heuristik salah satu diantaranya adalah Hill Climbing, Best First Search, A* (A Bintang. Loglist merupakan tempat penyimpanan setiap kunjungan dari state-state puzzle yang telah dilakukan untuk menghindari looping atau pengulangan terhadap state yang pernah dilalui. Untuk menanggulangi permasalahan pada SteepestAscent Hill Climbing.

  20. The Simple Past Puzzle. A Study of Some Aspects of the Syntax and Semantics of Tense

    Directory of Open Access Journals (Sweden)

    Nino Gulli

    2014-05-01

    Full Text Available In this paper, I claim that the so-called present perfect puzzle is, in reality, a puzzle about the simple past. It is the latter, I argue, that shows a puzzling behavior, given that it can be used not only in definite contexts but also in seemingly indefinite ones. I employ the notions of time frame and specifiability to show how the obvious distinction between the two tenses in terms of temporal logic can be accounted for. I also propose that the past morpheme -ed be considered a kind of verb determiner which selects a temporal XP as a complement. Such complement can be (and usually is expressed either in the sentence or in the larger discourse; however, it can also remain implicit, or covert.

  1. Effect of a puzzle on the process of students' learning about cardiac physiology.

    Science.gov (United States)

    Cardozo, Lais Tono; Miranda, Aline Soares; Moura, Maria José Costa Sampaio; Marcondes, Fernanda Klein

    2016-09-01

    The aim of the present study was to evaluate the effects of using a puzzle to learn about cardiac physiology. Students were divided into control and game groups. In class 1, the control group had a 2-h theoretical class about cardiac physiology, including a detailed description of the phases of the cardiac cycle, whereas the game group had a 50-min theoretical class without the description of the cardiac cycle. In class 2, the control group did an assessment exercise before an activity with the cardiac puzzle and the game group answered questions after the above-mentioned activity. While solving the puzzle, the students had to describe the cardiac cycle by relating the concepts of heart morphology and physiology. To evaluate short-term learning, the number of wrong answers and grades in the assessment exercise were compared between the control and game groups. To evaluate medium-term learning, we compared the grades obtained by students of the control and game groups in questions about cardiac physiology that formed part of the academic exam. In the assessment exercise, the game group presented a lower number of errors and higher score compared with the control group. In the academic exam, applied after both groups had used the puzzle, there was no difference in the scores obtained by the control and game groups in questions about cardiac physiology. These results showed a positive effect of the puzzle on students' learning about cardiac physiology compared with those not using the puzzle. Copyright © 2016 The American Physiological Society.

  2. Jigsaw puzzle metasurface for multiple functions: polarization conversion, anomalous reflection and diffusion.

    Science.gov (United States)

    Zhao, Yi; Cao, Xiangyu; Gao, Jun; Liu, Xiao; Li, Sijia

    2016-05-16

    We demonstrate a simple reconfigurable metasurface with multiple functions. Anisotropic tiles are investigated and manufactured as fundamental elements. Then, the tiles are combined in a certain sequence to construct a metasurface. Each of the tiles can be adjusted independently which is like a jigsaw puzzle and the whole metasurface can achieve diverse functions by different layouts. For demonstration purposes, we realize polarization conversion, anomalous reflection and diffusion by a jigsaw puzzle metasurface with 6 × 6 pieces of anisotropic tile. Simulated and measured results prove that our method offers a simple and effective strategy for metasurface design.

  3. PuzzleArt Therapy: Connecting the Pieces in Search of Answers

    Directory of Open Access Journals (Sweden)

    Jennifer Fortuna

    2016-10-01

    Full Text Available Alli Berman, a New York based artist, provided the cover art for the Fall 2016 issue of The Open Journal of Occupational Therapy (OJOT. “Sunlight Underwater” is a 12 piece PuzzleArt painting made from acrylic on American maple that measures 22x30. The PuzzleArt concept began as a simple exercise that evolved into a therapeutic modality. When a sudden stroke impacted Berman’s well-being and quality of life, it was art that helped her to make connections during recovery.

  4. An Easy & Fun Way to Teach about How Science "Works": Popularizing Haack's Crossword-Puzzle Analogy

    Science.gov (United States)

    Pavlova, Iglika V.; Lewis, Kayla C.

    2013-01-01

    Science is a complex process, and we must not teach our students overly simplified versions of "the" scientific method. We propose that students can uncover the complex realities of scientific thinking by exploring the similarities and differences between solving the familiar crossword puzzles and scientific "puzzles."…

  5. Having Fun and Accepting Challenges Are Natural Instincts: Jigsaw Puzzles to Challenge Students and Test Their Abilities While Having Fun!

    Science.gov (United States)

    Rodenbaugh, Hanna R.; Lujan, Heidi L.; Rodenbaugh, David W.; DiCarlo, Stephen E.

    2014-01-01

    Because jigsaw puzzles are fun, and challenging, students will endure and discover that persistence and grit are rewarded. Importantly, play and fun have a biological place just like sleep and dreams. Students also feel a sense of accomplishment when they have completed a puzzle. Importantly, the reward of mastering a challenge builds confidence…

  6. Instructional Media Production for Early Childhood Education: A. B. C. Jig-Saw Puzzle, a Model

    Science.gov (United States)

    Yusuf, Mudashiru Olalere; Olanrewaju, Olatayo Solomon; Soetan, Aderonke K.

    2015-01-01

    In this paper, a. b. c. jig-saw puzzle was produced for early childhood education using local materials. This study was a production based type of research, to serve as a supplemental or total learning resource. Its production followed four phases of development referred to as information, design, production and evaluation. The storyboard cards,…

  7. Gardner's Two Children Problems and Variations: Puzzles with Conditional Probability and Sample Spaces

    Science.gov (United States)

    Taylor, Wendy; Stacey, Kaye

    2014-01-01

    This article presents "The Two Children Problem," published by Martin Gardner, who wrote a famous and widely-read math puzzle column in the magazine "Scientific American," and a problem presented by puzzler Gary Foshee. This paper explains the paradox of Problems 2 and 3 and many other variations of the theme. Then the authors…

  8. Resolutions of Several Puzzles at Intermediate pT and Recent Developments in Correlation

    International Nuclear Information System (INIS)

    Hwa, Rudolph C.

    2006-01-01

    Some of the puzzles on hadron production at intermediate p T found at RHIC are explained as natural consequences of parton recombination. In that framework for hadronization the correlation among hadrons produced in jets can be calculated. Some new results on both near-side and away-side jet structures are presented

  9. High-mass twins & resolution of the reconfinement, masquerade and hyperon puzzles of compact star interiors

    International Nuclear Information System (INIS)

    Blaschke, David; Alvarez-Castillo, David E.

    2016-01-01

    We aim at contributing to the resolution of three of the fundamental puzzles related to the still unsolved problem of the structure of the dense core of compact stars (CS): (i) the hyperon puzzle: how to reconcile pulsar masses of 2 M ⊙ with the hyperon softening of the equation of state (EoS); (ii) the masquerade problem: modern EoS for cold, high density hadronic and quark matter are almost identical; and (iii) the reconfinement puzzle: what to do when after a deconfinement transition the hadronic EoS becomes favorable again? We show that taking into account the compositeness of baryons (by excluded volume and/or quark Pauli blocking) on the hadronic side and confining and stiffening effects on the quark matter side results in an early phase transition to quark matter with sufficient stiffening at high densities which removes all three present-day puzzles of CS interiors. Moreover, in this new class of EoS for hybrid CS falls the interesting case of a strong first order phase transition which results in the observable high mass twin star phenomenon, an astrophysical observation of a critical endpoint in the QCD phase diagram

  10. Free-style puzzle flap: the concept of recycling a perforator flap.

    Science.gov (United States)

    Feng, Kuan-Ming; Hsieh, Ching-Hua; Jeng, Seng-Feng

    2013-02-01

    Theoretically, a flap can be supplied by any perforator based on the angiosome theory. In this study, the technique of free-style perforator flap dissection was used to harvest a pedicled or free skin flap from a previous free flap for a second difficult reconstruction. The authors call this a free-style puzzle flap. For the past 3 years, the authors treated 13 patients in whom 12 pedicled free-style puzzle flaps were harvested from previous redundant free flaps and recycled to reconstruct soft-tissue defects at various anatomical locations. One free-style free puzzle flap was harvested from a previous anterolateral thigh flap for buccal cancer to reconstruct a foot defect. Total flap survival was attained in 12 of 13 flaps. One transferred flap failed completely. This patient had received postoperative radiotherapy after the initial cancer ablation and free anterolateral thigh flap reconstruction. Another free flap was used to close and reconstruct the wound. All the donor sites could be closed primarily. The free-style puzzle flap, harvested from a previous redundant free flap and used as a perforator flap to reconstruct a new defect, has proven to be versatile and reliable. When indicated, it is an alternative donor site for further reconstruction of soft-tissue defects.

  11. Enhancing the Understanding of Government and Nonprofit Accounting with THE PUZZLE GAME: A Pilot Study

    Science.gov (United States)

    Elson, Raymond J.; Ostapski, S. Andrew; O'Callaghan, Susanne; Walker, John P.

    2012-01-01

    Nontraditional teaching aids such as crossword puzzles have been successfully used in the classroom to enhance student learning. Government and nonprofit accounting is a confusing course for students since it has strange terminologies and contradicts the accounting concepts learned in other courses. As such, it is an ideal course for a…

  12. Precedents, Patterns and Puzzles: Feminist Reflections on the First Women Lawyers

    Directory of Open Access Journals (Sweden)

    Mary Jane Mossman

    2016-10-01

    Full Text Available This paper initially examines the historical precedents established by some of the first women who entered the “gentleman’s profession” of law in different jurisdictions, as well as the biographical patterns that shaped some women’s ambitions to enter the legal professions. The paper then uses feminist methods and theories to interpret “puzzles that remain unsolved” about early women lawyers, focusing especially on two issues. One puzzle is the repeated claims on the part of many of these early women lawyers that they were “lawyers”, and not “women lawyers”, even as they experienced exclusionary practices and discrimination on the part of male lawyers and judges—a puzzle that suggests how professional culture required women lawyers to conform to existing patterns in order to succeed. A second puzzle relates to the public voices of early women lawyers, which tended to suppress disappointments, difficulties and discriminatory practices. In this context, feminist theories suggest a need to be attentive to the “silences” in women’s stories, including the stories of the lives of early women lawyers. Moreover, these insights may have continuing relevance for contemporary women lawyers because it is at least arguable that, while there have been changes in women’s experiences, there has been very little transformation in their work status in relation to men.

  13. Chinese American and Caucasian American Family Interaction Patterns in Spatial Rotation Puzzle Solutions.

    Science.gov (United States)

    Hutsinger, Carol S.; Jose, Paul E.

    1995-01-01

    Examined sociocultural influences on mathematics achievement. First generation Chinese American and Caucasian American mother-father-daughter triads were audiotaped as the fifth- and sixth-grade girls solved a spatial puzzle. Chinese American triads were quieter, more respectful, more serious, and more orderly, whereas Caucasian American triads…

  14. Box-Cox transformation for resolving the Peelle's Pertinent Puzzle in a curve fitting

    International Nuclear Information System (INIS)

    Oh, S. Y.; Seo, C. G.

    2004-01-01

    Incorporating the Box-Cox transformation into a curve fitting is presented as one of methods for resolving an anomaly known as the Peelle's Pertinent Puzzle in the nuclear data community. The Box-Cox transformation is a strategy to make non-normal distribution data resemble normal distribution data. The proposed method consists of the following steps: transform the raw data to be fitted with the optimized Box-Cox transformation parameter, fit the transformed data using a conventional curve fitting tool, the least-squares method in this study, then inverse-transform the fitted results to the final estimates. Covariance matrices are correspondingly transformed and inverse-transformed with the aid of the law of error propagation. In addition to a sensible answer to the Puzzle, the proposed method resulted in reasonable estimates for a test evaluation with pseudo-experimental 6 Li(n, t) cross sections in several to 800 keV energy region, while the GMA code resulted in systematic underestimates that characterize the Puzzle. Meanwhile, it is observed that the present method and the Chiba-Smith method yield almost the same estimates for the test evaluation on 6 Li(n, t). Conceptually, however, two methods are very different from each other and further discussions are needed for a consensus on the issue of how to resolve the Puzzle. (authors)

  15. The Quark Puzzle: A Novel Approach to Visualizing the Color Symmetries of Quarks

    Science.gov (United States)

    Gettrust, Eric

    2010-01-01

    This paper describes a simple hands-on and visual-method designed to introduce physics students of many age groups to the topic of quarks and their role in forming composite particles (baryons and mesons). A set of puzzle pieces representing individual quarks that fit together in ways consistent with known restrictions of flavor, color, and charge…

  16. (Mis)perception of Sleep in Insomnia: A Puzzle and a Resolution

    Science.gov (United States)

    Harvey, Allison G.; Tang, Nicole K. Y.

    2012-01-01

    Insomnia is prevalent, causing severe distress and impairment. This review focuses on illuminating the puzzling finding that many insomnia patients misperceive their sleep. They overestimate their sleep onset latency (SOL) and underestimate their total sleep time (TST), relative to objective measures. This tendency is ubiquitous (although not…

  17. Geoscience Data Puzzles: Developing Students' Ability to Make Meaning from Data

    Science.gov (United States)

    Kastens, K. A.; Turrin, M.

    2010-12-01

    One of the most fundamental aspects of geoscience expertise is the ability to extract insights from observational earth data. Where an expert might see trends, patterns, processes, and candidate causal relationships, a novice could look at the same data representation and see dots, wiggles and blotches of color. The problem is compounded when the student was not personally involved in collecting the data or samples and thus has no experiential knowledge of the Earth setting that the data represent. In other words, the problem is especially severe when students tap into the vast archives of professionally-collected data that the geoscience community has worked so hard to make available for instructional use over the internet. Moreover, most high school and middle school teachers did not themselves learn Earth Science through analyzing data, and they may lack skills and/or confidence needed to scaffold students through the process of learning to interpret realistically-complex data sets. We have developed “Geoscience Data Puzzles” with the paired goals of (a) helping students learn about the earth from data, and (b) helping teachers learn to teach with data. Geoscience Data Puzzles are data-using activities that purposefully present a low barrier-to-entry for teachers and a high ratio of insight-to-effort for students. Each Puzzle uses authentic geoscience data, but the data are carefully pre-selected in order to illuminate a fundamental Earth process within tractable snippets of data. Every Puzzle offers "Aha" moments, when the connection between data and process comes clear in a rewarding burst of insight. Every Puzzle is accompanied by a Pedagogical Content Knowledge (PCK) guide, which explicates the chain of reasoning by which the puzzle-solver can use the evidence provided by the data to construct scientific claims. Four types of reasoning are stressed: spatial reasoning, in which students make inferences from observations about location, orientation, shape

  18. EZ Pegasi - The last pieces of the puzzle

    Science.gov (United States)

    Howell, S. B.; Williams, W. M.; Barden, S. C.; Bopp, B. W.

    1986-01-01

    Based on UBV differential photometric observations carried out at the Braeside Observatory between October 19, 1984 and January 11, 1985, it is shown that EZ Peg is in synchronous rotation with a photometric period of 11.6626 days. The orbital solution of Griffin (1985) is in good agreement with the present results, and it is employed to analyze the emission properties of the Ca II and H-alpha emission in the system. It is suggested that the emission of the system is almost entirely associated with the primary component, and the two stars appear to be similar in size and luminosity.

  19. Action and puzzle video games prime different speed/accuracy tradeoffs.

    Science.gov (United States)

    Nelson, Rolf A; Strachan, Ian

    2009-01-01

    To understand the way in which video-game play affects subsequent perception and cognitive strategy, two experiments were performed in which participants played either a fast-action game or a puzzle-solving game. Before and after video-game play, participants performed a task in which both speed and accuracy were emphasized. In experiment 1 participants engaged in a location task in which they clicked a mouse on the spot where a target had appeared, and in experiment 2 they were asked to judge which of four shapes was most similar to a target shape. In both experiments, participants were much faster but less accurate after playing the action game, while they were slower but more accurate after playing the puzzle game. Results are discussed in terms of a taxonomy of video games by their cognitive and perceptual demands.

  20. Puzzle of the particles and the universe. The inner life of the elementary particles IX d

    International Nuclear Information System (INIS)

    Geitner, Uwe W.

    2013-01-01

    The series The Inner Life of the Elementary Particles attempts to develop the elementary particles along of a genealogical tree, which begins before the ''big bang''. The simple presentation without mathematics opens also for the interested layman a plastic understanding. Volume IX discusses the known puzzles of particle physics and cosmology and offers for many of them explanation models. Explanation approaches are among others the ''DNA'' of the elementary particles and the interpretation of the quanta and the spin.

  1. The Loss Aversion / Narrow Framing Approach to the Equity Premium Puzzle

    OpenAIRE

    Nicholas Barberis; Ming Huang

    2006-01-01

    We review a recent approach to understanding the equity premium puzzle. The key elements of this approach are loss aversion and narrow framing, two well-known features of decision-making under risk in experimental settings. In equilibrium, models that incorporate these ideas can generate a large equity premium and a low and stable risk-free rate, even when consumption growth is smooth and only weakly correlated with the stock market. Moreover, they can do so for parameter values that correspo...

  2. Review of Experimental and Theoretical Status of the Proton Radius Puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Richard J. [TRIUMF

    2017-01-01

    The discrepancy between the measured Lamb shift in muonic hydrogen and expectations from electron-proton scattering and regular hydrogen spectroscopy has become known as the proton radius puzzle, whose most “mundane” resolution requires a > 5σ shift in the value of the fundamental Rydberg constant. I briefly review the status of spectroscopic and scattering measurements, recent theoretical developments, and implications for fundamental physics.

  3. The height of Tennessee convicts: another piece of the "antebellum puzzle".

    Science.gov (United States)

    Sunder, Marco

    2004-03-01

    Average height of the free population in the United States born in the mid-1830s began to decline despite growing per capita incomes. Explanations for this "antebellum puzzle" revolve around a possibly deteriorating disease environment promoted by urban agglomeration and increases in the relative price of protein-rich foods. However, several groups were immune to the effect, including members of the middle class, whose income was high enough, and increased enough to overcome the adverse developments and maintain their nutritional status. Although at the opposite end of the social spectrum, the height of male slaves also increased, as it was in their owners' interest to raise their slaves' food allotments. The height of Tennessee convicts, analyzed in this article, also increased in the late-1830s, being the third exception to the "antebellum puzzle." Mid-19th century Tennessee was integrated into interstate commerce in cotton and tobacco and experienced considerable movement of people who would have brought with them diseases from elsewhere, hence, it would have been integrated into the US disease pool, and the fact that heights did not decline in the 1830s is therefore an indication that the antebellum puzzle cannot be explained exclusively by the spread of diseases. Yet, Tennessee's economy was quite different to that of the rest of the country. Although it did export live swine to the South, these exports did not increase during the antebellum decades. Hence, Tennessee remained self-sufficient in pork, and consumption of pork did not decline. Thus, the evidence presented here is consistent with the economic interpretation of the "antebellum puzzle": self-sufficiency in protein production protected even the members of the lower-classes of Tennessee from the negative externalities associated with the onset of industrialization.

  4. The puzzle of new etiological agents in the Americas: Punta del Toro virus another piece?

    Directory of Open Access Journals (Sweden)

    Salim Mattar V

    2017-01-01

    Full Text Available In a recent study of undifferentiated tropical fevers in an endemic area of Colombia, it was shown that not all acute fevers are caused by the dengue virus (1. The complex clinical-epidemiological panorama of tropical fevers has become a puzzle of difficult resolution due to the appearance of new etiological agents in the Americas such as Chikungunya and Zika. For the differential diagnosis Hantavirus, Arenavirus, Orupuche, tick thrombocytopenic virus, Heartland virus, leptospira and malaria should be considered.

  5. (Mis)perception of sleep in insomnia: a puzzle and a resolution.

    Science.gov (United States)

    Harvey, Allison G; Tang, Nicole K Y

    2012-01-01

    Insomnia is prevalent, causing severe distress and impairment. This review focuses on illuminating the puzzling finding that many insomnia patients misperceive their sleep. They overestimate their sleep onset latency (SOL) and underestimate their total sleep time (TST), relative to objective measures. This tendency is ubiquitous (although not universal). Resolving this puzzle has clinical, theoretical, and public health importance. There are implications for assessment, definition, and treatment. Moreover, solving the puzzle creates an opportunity for real-world applications of theories from clinical, perceptual, and social psychology as well as neuroscience. Herein we evaluate 13 possible resolutions to the puzzle. Specifically, we consider the possible contribution, to misperception, of (1) features inherent to the context of sleep (e.g., darkness); (2) the definition of sleep onset, which may lack sensitivity for insomnia patients; (3) insomnia being an exaggerated sleep complaint; (4) psychological distress causing magnification; (5) a deficit in time estimation ability; (6) sleep being misperceived as wake; (7) worry and selective attention toward sleep-related threats; (8) a memory bias influenced by current symptoms and emotions, a confirmation bias/belief bias, or a recall bias linked to the intensity/recency of symptoms; (9) heightened physiological arousal; (10) elevated cortical arousal; (11) the presence of brief awakenings; (12) a fault in neuronal circuitry; and (13) there being 2 insomnia subtypes (one with and one without misperception). The best supported resolutions were misperception of sleep as wake, worry, and brief awakenings. A deficit in time estimation ability was not supported. We conclude by proposing several integrative solutions.

  6. Black-hole information puzzle: a generic string-inspired approach

    International Nuclear Information System (INIS)

    Nikolic, H.

    2008-01-01

    Given the insight stemming from string theory, the origin of the black-hole (BH) information puzzle is traced back to the assumption that it is physically meaningful to trace out the density matrix over negative-frequency Hawking particles. Instead, treating them as virtual particles necessarily absorbed by the BH in a manner consistent with the laws of BH thermodynamics, and tracing out the density matrix only over physical BH states, complete evaporation becomes compatible with unitarity. (orig.)

  7. An Analysis of Closed-end Fund Puzzle for Emerging Capital Markets

    Directory of Open Access Journals (Sweden)

    Victor Dragota

    2008-10-01

    Full Text Available This paper analyzes the closed-end fund puzzle for an emerging capital market, respectively the Romanian one. Comparatively to more developed markets, as long as small markets are often very illiquid, it has to be used some specific valuation techniques in order to estimate the market values for closed-end funds. Also, one problem is this estimation can be made only in some (punctual moments.

  8. The Puzzle of Democratic Monopolies: Single Party Dominance and Decline in India

    OpenAIRE

    Dasgupta, Aditya

    2016-01-01

    How to explain political monopolies in democratic institutional settings? Dominant parties in countries with robust formal democratic institutions are surprisingly frequent, yet poorly understood. Existing theories explain away the puzzle by characterizing dominant parties as `catch-all' parties that survive on the basis of historically imbued mass voter legitimacy. This dissertation develops a theory of how dominant parties in fact routinely win free and fair elections despite counter-majori...

  9. Understanding the proton radius puzzle: Nuclear structure effects in light muonic atoms

    Directory of Open Access Journals (Sweden)

    Ji Chen

    2016-01-01

    Full Text Available We present calculations of nuclear structure effects to the Lamb shift in light muonic atoms. We adopt a modern ab-initio approach by combining state-of-the-art nuclear potentials with the hyperspherical harmonics method. Our calculations are instrumental to the determination of nuclear charge radii in the Lamb shift measurements, which will shed light on the proton radius puzzle.

  10. Puzzling the Jesus of the Parables: A response to Ruben Zimmermann

    Directory of Open Access Journals (Sweden)

    Llewellyn Howes

    2017-07-01

    Full Text Available This article responds to Ruben Zimmermann’s latest book, Puzzling the Parables of Jesus (2015. In particular, one aspect of his proposed method is challenged, namely, his conscious attempt to do away with considerations of the pre-Easter context when interpreting the parables. The article finishes by proposing a variant methodology of parable interpretation, featuring the parable of the Good Samaritan as a working example.

  11. International Evidence on the Role of Monetary Policy in the Uncovered Interest Rate Parity Puzzle

    OpenAIRE

    Alfred V Guender

    2015-01-01

    CPI inflation targeting necessitates a flexible exchange rate regime. This paper embeds an endogenous target rule into a simple open economy macro model to explain the UIP puzzle. The model predicts that the change in the exchange rate is inversely related to the lagged interest rate differential. Openness and aversion to inflation variability determine the strength of this linkage. Foreign inflation and the foreign interest rate also affect exchange rate changes. This hypothesis is tested on...

  12. A solution to B→ππ puzzle and B→KK

    International Nuclear Information System (INIS)

    Baek, Seungwon

    2008-01-01

    The large ratio of color-suppressed tree amplitude to color-allowed one in B→ππ decays is difficult to understand within the Standard Model, which is known as the 'B→ππ puzzle'. The two tree diagrams contain the up- and charm-quark component of penguin amplitude, P uc , which cannot be separated by measuring B→ππ decays alone. We show that the measurements of the branching ratio and direct CP asymmetry of B + →K + K 0 -bar decay enable one to disentangle the P uc with two-fold ambiguity. One of the two degenerate solutions of the P uc can solve the B→ππ puzzle by giving |C/T|∼0.3 which is consistent with the expectation in the Standard Model. We also show that the two solutions can be discriminated by the measurement of the indirect CP asymmetry of B 0 →K 0 K 0 -bar. We point out that the corresponding puzzle in B→πK decays is not solved in this way

  13. Right frontal gamma and beta band enhancement while solving a spatial puzzle with insight.

    Science.gov (United States)

    Rosen, A; Reiner, M

    2017-12-01

    Solving a problem with an "a-ha" effect is known as insight. Unlike incremental problem solving, insight is sudden and unique, and the question about its distinct brain activity, intrigues many researchers. In this study, electroencephalogram signals were recorded from 12 right handed, human participants before (baseline) and while they solved a spatial puzzle known as the '10 coin puzzle' that could be solved incrementally or by insight. Participants responded as soon as they reached a solution and reported whether the process was incremental or by sudden insight. EEG activity was recorded from 19 scalp locations. We found significant differences between insight and incremental solvers in the Gamma and Beta 2 bands in frontal areas (F8) and in the alpha band in right temporal areas (T6). The right-frontal gamma indicates a process of restructuring which leads to an insight solution, in spatial problems, further suggesting a universal role of gamma in restructuring. These results further suggest that solving a spatial puzzle via insight requires exclusive brain areas and neurological-cognitive processes which may be important for meta-cognitive components of insight solutions, including attention and monitoring of the solution. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. A puzzle assembly strategy for fabrication of large engineered cartilage tissue constructs.

    Science.gov (United States)

    Nover, Adam B; Jones, Brian K; Yu, William T; Donovan, Daniel S; Podolnick, Jeremy D; Cook, James L; Ateshian, Gerard A; Hung, Clark T

    2016-03-21

    Engineering of large articular cartilage tissue constructs remains a challenge as tissue growth is limited by nutrient diffusion. Here, a novel strategy is investigated, generating large constructs through the assembly of individually cultured, interlocking, smaller puzzle-shaped subunits. These constructs can be engineered consistently with more desirable mechanical and biochemical properties than larger constructs (~4-fold greater Young׳s modulus). A failure testing technique was developed to evaluate the physiologic functionality of constructs, which were cultured as individual subunits for 28 days, then assembled and cultured for an additional 21-35 days. Assembled puzzle constructs withstood large deformations (40-50% compressive strain) prior to failure. Their ability to withstand physiologic loads may be enhanced by increases in subunit strength and assembled culture time. A nude mouse model was utilized to show biocompatibility and fusion of assembled puzzle pieces in vivo. Overall, the technique offers a novel, effective approach to scaling up engineered tissues and may be combined with other techniques and/or applied to the engineering of other tissues. Future studies will aim to optimize this system in an effort to engineer and integrate robust subunits to fill large defects. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Padrão dos fluxos de capitais: teoria, evidência e puzzle

    Directory of Open Access Journals (Sweden)

    Aderbal Oliveira Damasceno

    2014-04-01

    Full Text Available Este trabalho desenvolve uma análise teórica e empírica sobre o padrão de longo prazo dos fluxos de capitais. Com uma amostra de 105 países e dados para o período 1980-2004, a metodologia econométrica abrange modelos para cross-section e para dados em painel. Os resultados apresentados sugerem: i incoerência entre as previsões do modelo neoclássico e o padrão observado dos fluxos de capitais, o que caracteriza o puzzle ; ii no âmbito da abordagem convencional, as explicações para o puzzle são diferenças de fundamentos entre países e imperfeições no mercado financeiro; iii não há evidências de que diferenças entre os países relativas ao ambiente institucional, estoque de capital humano, integração financeira, política macroeconòmica e desenvolvimento financeiro expliquem o puzzle. Considerando os resultados apresentados, esboça-se uma explicação alternativa de inspiração heterodoxa para o padrão dos fluxos de capitais.

  16. An Interactive 3D Virtual Anatomy Puzzle for Learning and Simulation - Initial Demonstration and Evaluation.

    Science.gov (United States)

    Messier, Erik; Wilcox, Jascha; Dawson-Elli, Alexander; Diaz, Gabriel; Linte, Cristian A

    2016-01-01

    To inspire young students (grades 6-12) to become medical practitioners and biomedical engineers, it is necessary to expose them to key concepts of the field in a way that is both exciting and informative. Recent advances in medical image acquisition, manipulation, processing, visualization, and display have revolutionized the approach in which the human body and internal anatomy can be seen and studied. It is now possible to collect 3D, 4D, and 5D medical images of patient specific data, and display that data to the end user using consumer level 3D stereoscopic display technology. Despite such advancements, traditional 2D modes of content presentation such as textbooks and slides are still the standard didactic equipment used to teach young students anatomy. More sophisticated methods of display can help to elucidate the complex 3D relationships between structures that are so often missed when viewing only 2D media, and can instill in students an appreciation for the interconnection between medicine and technology. Here we describe the design, implementation, and preliminary evaluation of a 3D virtual anatomy puzzle dedicated to helping users learn the anatomy of various organs and systems by manipulating 3D virtual data. The puzzle currently comprises several components of the human anatomy and can be easily extended to include additional organs and systems. The 3D virtual anatomy puzzle game was implemented and piloted using three display paradigms - a traditional 2D monitor, a 3D TV with active shutter glass, and the DK2 version Oculus Rift, as well as two different user interaction devices - a space mouse and traditional keyboard controls.

  17. "It's like a puzzle": Pregnant women's perceptions of professional support in midwifery care.

    Science.gov (United States)

    Bäckström, Caroline A; Mårtensson, Lena B; Golsäter, Marie H; Thorstensson, Stina A

    2016-12-01

    Pregnant women are not always satisfied with the professional support they receive during their midwifery care. More knowledge is needed to understand what professional support pregnant women need for childbirth and parenting. Childbearing and the transition to becoming a parent is a sensitive period in one's life during which one should have the opportunity to receive professional support. Professional support does not always correspond to pregnant women's needs. To understand pregnant women's needs for professional support within midwifery care, it is crucial to further illuminate women's experiences of this support. To explore pregnant women's perceptions of professional support in midwifery care. A qualitative study using semi-structured interviews. Fifteen women were interviewed during gestational weeks 36-38. Data was analysed using phenomenography. The women perceived professional support in midwifery care to be reassuring and emotional, to consist of reliable information, and to be mediated with pedagogical creativity. The professional support facilitated new social contacts, partner involvement and contributed to mental preparedness. The findings of the study were presented in six categories and the category Professional support contributes to mental preparedness was influenced by the five other categories. Pregnant women prepare for childbirth and parenting by using several different types of professional support in midwifery care: a strategy that could be described as piecing together a puzzle. When the women put the puzzle together, each type of professional support works as a valuable piece in the whole puzzle. Through this, professional support could contribute to women's mental preparedness for childbirth and parenting. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  18. Exchange rate regimes, saving glut and the Feldstein Horioka puzzle: The East Asian experience

    Science.gov (United States)

    Kaya-Bahçe, Seçil; Özmen, Erdal

    2008-04-01

    This paper investigates whether the recent experience of the emerging East Asian countries with current account surpluses is consistent with the “saving glut” hypothesis and the Feldstein and Horioka puzzle. The evidence suggests that the saving retention coefficients declined substantially in most of the countries after an endogenous break date coinciding with a major exchange rate regime change with the 1997-1998 crisis. Exchange rate flexibility appears to be enhancing financial integration. The results are consistent with an “investment slump” explanation rather than the “saving glut” postulation.

  19. Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: piece by piece.

    Science.gov (United States)

    Lundy, David J; Lee, Desy S; Hsieh, Patrick C H

    2017-03-01

    There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al ., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.

  20. The Puzzle of Simultaneous Anti-Dumping and Anti-Subsidy Measures

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Ulff-Møller; Hansen, Jørgen Drud

    be a surprise, as the same total level of protection may be obtained by using the anti-dumping procedure exclusively. When calculating the two duties in the EU the outcome depends on whether the subsidies are export subsidies or domestic subsidies and this may also cause surprise. This paper addresses...... these puzzles in a theoretical analysis based on a duopoly model for a horizontally differentiated product. We argue that the procedures of two investigations leading to a two-component duty may be rational because it provides an incentive for the offending country and companies to terminate their ‘unfair...

  1. Effects of age and type of picture on visuospatial working memory assessed with a computerized jigsaw-puzzle task.

    Science.gov (United States)

    Toril, Pilar; Reales, José M; Mayas, Julia; Ballesteros, Soledad

    2017-09-15

    We investigated the effect of age and color in a computerized version of the jigsaw-puzzle task. In Experiment 1, young and older adults were presented with puzzles in color and black-and-white line drawings, varying in difficulty from 4 to 9 pieces. Older adults performed the task better with the black-and-white stimuli and younger adults performed better with the color ones. In Experiment 2, new older and young adults identified the same fragmented pictures as fast and accurately as possible. The older group identified the black-and-white stimuli faster than those presented in color, while the younger adults identified both similarly. In Experiment 3A, new older and young groups performed the puzzle task with the same color pictures and their monochrome versions. In Experiment 3B, participants performed a speeded identification task with the two sets. The findings of these experiments showed that older adults have a memory not a perceptual difficulty.

  2. Puzzling antimatter

    CERN Multimedia

    Francesco Poppi

    2010-01-01

    For many years, the absence of antimatter in the Universe has tantalised particle physicists and cosmologists: while the Big Bang should have created equal amounts of matter and antimatter, we do not observe any primordial antimatter today. Where has it gone? The LHC experiments have the potential to unveil natural processes that could hold the key to solving this paradox.   Every time that matter is created from pure energy, equal amounts of particles and antiparticles are generated. Conversely, when matter and antimatter meet, they annihilate and produce light. Antimatter is produced routinely when cosmic rays hit the Earth's atmosphere, and the annihilations of matter and antimatter are observed during physics experiments in particle accelerators. If the Universe contained antimatter regions, we would be able to observe intense fluxes of photons at the boundaries of the matter/antimatter regions. “Experiments measuring the diffuse gamma-ray background in the Universe would be able...

  3. Phthalate Puzzle

    Indian Academy of Sciences (India)

    difficulties in working with it and thereby limited its applicability. Plasticized PVC, a ... performance rather than physical properties as its incorporation increases ... Adult women had higher levels of urinary metabolites than men as phthalates ...

  4. Puzzling asymmetries

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In a recently published paper, the LHCb collaboration reported on a possible deviation from the Standard Model. Theorists are now working to calculate precisely this effect and to evaluate the implications that such an unexpected result could have on the established theory.   The Standard Model is able to predict the decay rates of particles with high precision. In most cases, experimentalists confirm the value predicted by theory and the figure is added to the official publications. However, this time, things seem to have taken a different route. Studying data collected in 2011, the LHCb collaboration found that in a specific decay – a B particle transforming into a K particle plus two charged muons (B -> Kμ-μ+) – the branching ratio of the neutral B in the corresponding decay (i.e. B0 -> K0μ-μ+) was different it that of the positively charged B (i.e. B+ -> K+μ-μ+). Such an “isospin asymmetry”...

  5. Puzzling asymmetries

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    In a recently published paper, the LHCb Collaboration has reported on a possible deviation from the Standard Model. Theorists are now working to calculate precisely this effect and to evaluate the implications that such unexpected result could have on the established theory.   The Standard Model is able to predict the decay rates of particles with high precision. In most cases, experimentalists confirm the value predicted by theory and the figure is added to the official publications. However, this time, things seem to have taken a different route. Studying data collected in 2011, the LHCb Collaboration found that in a specific decay – a B particle transforming into a K particle plus two charged muons (B -> Kμ-μ+) – the branching ratio of the neutral B in the corresponding decay (i.e. B0 -> K0μ-μ+) is different from that of the positively charged B (i.e. B+ -> K+μ-μ+). Such an “isospin asymmetry&rdquo...

  6. A comparative study of the A* heuristic search algorithm used to solve efficiently a puzzle game

    Science.gov (United States)

    Iordan, A. E.

    2018-01-01

    The puzzle game presented in this paper consists in polyhedra (prisms, pyramids or pyramidal frustums) which can be moved using the free available spaces. The problem requires to be found the minimum number of movements in order the game reaches to a goal configuration starting from an initial configuration. Because the problem is enough complex, the principal difficulty in solving it is given by dimension of search space, that leads to necessity of a heuristic search. The improving of the search method consists into determination of a strong estimation by the heuristic function which will guide the search process to the most promising side of the search tree. The comparative study is realized among Manhattan heuristic and the Hamming heuristic using A* search algorithm implemented in Java. This paper also presents the necessary stages in object oriented development of a software used to solve efficiently this puzzle game. The modelling of the software is achieved through specific UML diagrams representing the phases of analysis, design and implementation, the system thus being described in a clear and practical manner. With the purpose to confirm the theoretical results which demonstrates that Manhattan heuristic is more efficient was used space complexity criterion. The space complexity was measured by the number of generated nodes from the search tree, by the number of the expanded nodes and by the effective branching factor. From the experimental results obtained by using the Manhattan heuristic, improvements were observed regarding space complexity of A* algorithm versus Hamming heuristic.

  7. The Equity Premium Puzzle: Analysis in Brazil after the Real Plan

    Directory of Open Access Journals (Sweden)

    Fábio Augusto Reis Gomes

    2013-04-01

    Full Text Available Our paper investigates whether there is evidence of an Equity Premium Puzzle (EPP in Brazil, applying two different methodologies. The EPP was identified by Mehra and Prescott (1985 since the Consumption Capital Asset Pricing Model (CCAPM, when calibrated with reasonable preference parameters, could not explain high historical average risk premiums in the United States. In our first approach, we consider Mehra’s (2003 model and calibrate the coefficient of risk aversion, using 1995:2-2012:1 quarterly data. The Ibovespa index was used as a measure of the market return, whereas the risk-free rate was proxied by the Selic interbank rate and by the savings account rate. In our second approach, we propose a new method to test the puzzle. We jointly estimate, via generalized method of moments, the parameters of interest using a moment condition that has not been previously explored, as far as we are aware of. The two approaches produced a high risk aversion coefficient, however the second approach indicated that we cannot reject the hypothesis of the risk aversion coefficient being statistically equal to zero. A possible explanation for this result might be that in Brazil the equity premium is not statistically different from zero. Therefore there is no evidence of EPP in Brazil for the studied period.

  8. Quantum top secret. The solution of the quantum puzzle. Metamorphosis of a picture of world

    International Nuclear Information System (INIS)

    Wingert, M.

    2008-01-01

    Many physicists believe that because of unexplained causes, which must anyway be concerned with the quantum puzzle and the mysterious consciousness, it would be no more possible to understand the real structure of the reality - this subtle smiling of the nature, which irritates the physicists since 100 years and the disturbed the theoretical physics so much that they threw the towel. Since nature is considered as absurd, strange, and crazy - and quantum theory as very complicated. But in reality the basic experiments are of a touching simplicity, which seems only completely unintelligible in the picture of world of mechanics. For these experiments show that the concept of body of mechanics and the body conceptions of the thinking cannot at all match the structure of nature. If this is objectively taken notice of without doubting on the existence of a reality, the experiments show the real, unveiled face of the nature. Light and matter must then consist of fields, which can themselves divide by non-mechanical way, so with wholeness, comparable only with cell division and branching processes in biology. Either it is completely crazy - or the only logic interpretation, which hitherto only no physicist risked to think. For these experiments disprove the atom and elementary-particle hypothesis, the picture of world of mechanics, and also the quantum-mechanical interpretation - and indeed uniquely. This knowledge could break the Gordian knot, solve the quantum puzzle, and also give away the secret of the thinking spirit

  9. New Nuclear Magnetic Moment of 209Bi: Resolving the Bismuth Hyperfine Puzzle

    Science.gov (United States)

    Skripnikov, Leonid V.; Schmidt, Stefan; Ullmann, Johannes; Geppert, Christopher; Kraus, Florian; Kresse, Benjamin; Nörtershäuser, Wilfried; Privalov, Alexei F.; Scheibe, Benjamin; Shabaev, Vladimir M.; Vogel, Michael; Volotka, Andrey V.

    2018-03-01

    A recent measurement of the hyperfine splitting in the ground state of Li-like 80+208Bi has established a "hyperfine puzzle"—the experimental result exhibits a 7 σ deviation from the theoretical prediction [J. Ullmann et al., Nat. Commun. 8, 15484 (2017), 10.1038/ncomms15484; J. P. Karr, Nat. Phys. 13, 533 (2017), 10.1038/nphys4159]. We provide evidence that the discrepancy is caused by an inaccurate value of the tabulated nuclear magnetic moment (μI) of 209Bi. We perform relativistic density functional theory and relativistic coupled cluster calculations of the shielding constant that should be used to extract the value of μI(209ipts>) and combine it with nuclear magnetic resonance measurements of Bi (NO3 )3 in nitric acid solutions and of the hexafluoridobismuthate(V) BiF6- ion in acetonitrile. The result clearly reveals that μI(209Bi) is much smaller than the tabulated value used previously. Applying the new magnetic moment shifts the theoretical prediction into agreement with experiment and resolves the hyperfine puzzle.

  10. A Hybrid alldifferent-Tabu Search Algorithm for Solving Sudoku Puzzles

    Directory of Open Access Journals (Sweden)

    Ricardo Soto

    2015-01-01

    Full Text Available The Sudoku problem is a well-known logic-based puzzle of combinatorial number-placement. It consists in filling a n2 × n2 grid, composed of n columns, n rows, and n subgrids, each one containing distinct integers from 1 to n2. Such a puzzle belongs to the NP-complete collection of problems, to which there exist diverse exact and approximate methods able to solve it. In this paper, we propose a new hybrid algorithm that smartly combines a classic tabu search procedure with the alldifferent global constraint from the constraint programming world. The alldifferent constraint is known to be efficient for domain filtering in the presence of constraints that must be pairwise different, which are exactly the kind of constraints that Sudokus own. This ability clearly alleviates the work of the tabu search, resulting in a faster and more robust approach for solving Sudokus. We illustrate interesting experimental results where our proposed algorithm outperforms the best results previously reported by hybrids and approximate methods.

  11. A resolution of the inclusive flavor-breaking τ |Vus| puzzle

    Science.gov (United States)

    Hudspith, Renwick J.; Lewis, Randy; Maltman, Kim; Zanotti, James

    2018-06-01

    We revisit the puzzle of |Vus | values obtained from the conventional implementation of hadronic-τ- decay-based flavor-breaking finite-energy sum rules lying > 3 σ below the expectations of three-family unitarity. Significant unphysical dependences of |Vus | on the choice of weight, w, and upper limit, s0, of the experimental spectral integrals entering the analysis are confirmed, and a breakdown of assumptions made in estimating higher dimension, D > 4, OPE contributions identified as the main source of these problems. A combination of continuum and lattice results is shown to suggest a new implementation of the flavor-breaking sum rule approach in which not only |Vus |, but also D > 4 effective condensates, are fit to data. Lattice results are also used to clarify how to reliably treat the slowly converging D = 2 OPE series. The new sum rule implementation is shown to cure the problems of the unphysical w- and s0-dependence of |Vus | and to produce results ∼0.0020 higher than those of the conventional implementation employing the same data. With B-factory input, and using, in addition, dispersively constrained results for the Kπ branching fractions, we find |Vus | = 0.2231(27)exp(4)th, in excellent agreement with the result from Kℓ3, and compatible within errors with the expectations of three-family unitarity, thus resolving the long-standing inclusive τ |Vus | puzzle.

  12. New Nuclear Magnetic Moment of ^{209}Bi: Resolving the Bismuth Hyperfine Puzzle.

    Science.gov (United States)

    Skripnikov, Leonid V; Schmidt, Stefan; Ullmann, Johannes; Geppert, Christopher; Kraus, Florian; Kresse, Benjamin; Nörtershäuser, Wilfried; Privalov, Alexei F; Scheibe, Benjamin; Shabaev, Vladimir M; Vogel, Michael; Volotka, Andrey V

    2018-03-02

    A recent measurement of the hyperfine splitting in the ground state of Li-like ^{208}Bi^{80+} has established a "hyperfine puzzle"-the experimental result exhibits a 7σ deviation from the theoretical prediction [J. Ullmann et al., Nat. Commun. 8, 15484 (2017)NCAOBW2041-172310.1038/ncomms15484; J. P. Karr, Nat. Phys. 13, 533 (2017)NPAHAX1745-247310.1038/nphys4159]. We provide evidence that the discrepancy is caused by an inaccurate value of the tabulated nuclear magnetic moment (μ_{I}) of ^{209}Bi. We perform relativistic density functional theory and relativistic coupled cluster calculations of the shielding constant that should be used to extract the value of μ_{I}(^{209}Bi) and combine it with nuclear magnetic resonance measurements of Bi(NO_{3})_{3} in nitric acid solutions and of the hexafluoridobismuthate(V) BiF_{6}^{-} ion in acetonitrile. The result clearly reveals that μ_{I}(^{209}Bi) is much smaller than the tabulated value used previously. Applying the new magnetic moment shifts the theoretical prediction into agreement with experiment and resolves the hyperfine puzzle.

  13. A Computational/Experimental Platform for Investigating Three-Dimensional Puzzle Solving of Comminuted Articular Fractures

    Science.gov (United States)

    Thomas, Thaddeus P.; Anderson, Donald D.; Willis, Andrew R.; Liu, Pengcheng; Frank, Matthew C.; Marsh, J. Lawrence; Brown, Thomas D.

    2011-01-01

    Reconstructing highly comminuted articular fractures poses a difficult surgical challenge, akin to solving a complicated three-dimensional (3D) puzzle. Pre-operative planning using CT is critically important, given the desirability of less invasive surgical approaches. The goal of this work is to advance 3D puzzle solving methods toward use as a pre-operative tool for reconstructing these complex fractures. Methodology for generating typical fragmentation/dispersal patterns was developed. Five identical replicas of human distal tibia anatomy, were machined from blocks of high-density polyetherurethane foam (bone fragmentation surrogate), and were fractured using an instrumented drop tower. Pre- and post-fracture geometries were obtained using laser scans and CT. A semi-automatic virtual reconstruction computer program aligned fragment native (non-fracture) surfaces to a pre-fracture template. The tibias were precisely reconstructed with alignment accuracies ranging from 0.03-0.4mm. This novel technology has potential to significantly enhance surgical techniques for reconstructing comminuted intra-articular fractures, as illustrated for a representative clinical case. PMID:20924863

  14. Puzzle of magnetic moments of Ni clusters revisited using quantum Monte Carlo method.

    Science.gov (United States)

    Lee, Hung-Wen; Chang, Chun-Ming; Hsing, Cheng-Rong

    2017-02-28

    The puzzle of the magnetic moments of small nickel clusters arises from the discrepancy between values predicted using density functional theory (DFT) and experimental measurements. Traditional DFT approaches underestimate the magnetic moments of nickel clusters. Two fundamental problems are associated with this puzzle, namely, calculating the exchange-correlation interaction accurately and determining the global minimum structures of the clusters. Theoretically, the two problems can be solved using quantum Monte Carlo (QMC) calculations and the ab initio random structure searching (AIRSS) method correspondingly. Therefore, we combined the fixed-moment AIRSS and QMC methods to investigate the magnetic properties of Ni n (n = 5-9) clusters. The spin moments of the diffusion Monte Carlo (DMC) ground states are higher than those of the Perdew-Burke-Ernzerhof ground states and, in the case of Ni 8-9 , two new ground-state structures have been discovered using the DMC calculations. The predicted results are closer to the experimental findings, unlike the results predicted in previous standard DFT studies.

  15. Toward a solution to the RAA and v2 puzzle for heavy quarks

    Directory of Open Access Journals (Sweden)

    Santosh K. Das

    2015-07-01

    Full Text Available The heavy quarks constitute a unique probe of the quark–gluon plasma properties. A puzzling relation between the nuclear modification factor RAA(pT and the elliptic flow v2(pT has been observed both at RHIC and LHC energies. Predicting correctly both observables has been a challenge to all existing models, especially for D mesons. We discuss how the temperature dependence of the heavy quark drag coefficient is responsible for a large part of such a puzzle. In particular, we have considered four different models to evaluate the temperature dependence of drag and diffusion coefficients propagating through a quark gluon plasma (QGP. All the four different models are set to reproduce the same RAA(pT observed in experiments at RHIC and LHC energy. We point out that for the same RAA(pT one can generate 2–3 times more v2 depending on the temperature dependence of the heavy quark drag coefficient. A non-decreasing drag coefficient as T→Tc is a major ingredient for a simultaneous description of RAA(pT and v2(pT.

  16. The puzzle of the 6Li quadrupole moment: steps toward the solution

    International Nuclear Information System (INIS)

    Blokhintsev, L.D.; Kukulin, V.I.; Pomerantsev, V.N.

    2005-01-01

    The problem of origin of the ground-state 6 Li quadrupole deformation has been investigated with account of the three-deuteron component of this nucleus wave function. two long-standing puzzles related to the tensor interaction in 6 Li are known. The first one lies in the anomalously small value of the 6 Li quadrupole moment which, being negative, is in absolute magnitude smaller by the factor of 5 than that of 6 Li. The second puzzle consists in the anomalous behavior of the tensor analyzing power T 2q in scattering of polarized 6 Li nuclei from various targets. It is shown that the large (in absolute magnitude) negative contribution to the 6 Li quadrupole moment resulting from the three-deuteron configuration cancels almost completely the direct positive contribution due to the folding αd-potential. As a result, the total quadrupole moment turns out to be close to zero and highly sensitive to fine details of the tensor NN interaction and of the 4 He wave function [ru

  17. Heavy flavor puzzle at LHC: a serendipitous interplay of jet suppression and fragmentation.

    Science.gov (United States)

    Djordjevic, Magdalena

    2014-01-31

    Both charged hadrons and D mesons are considered to be excellent probes of QCD matter created in ultrarelativistic heavy ion collisions. Surprisingly, recent experimental observations at LHC show the same jet suppression for these two probes, which--contrary to pQCD expectations--may suggest similar energy losses for light quarks and gluons in the QCD medium. We here use our recently developed energy loss formalism in a finite-size dynamical QCD medium to analyze this phenomenon that we denote as the "heavy flavor puzzle at LHC." We show that this puzzle is a consequence of an unusual combination of the suppression and fragmentation patterns and, in fact, does not require invoking the same energy loss for light partons. Furthermore, we show that this combination leads to a simple relationship between the suppressions of charged hadrons and D mesons and the corresponding bare quark suppressions. Consequently, a coincidental matching of jet suppression and fragmentation allows considerably simplifying the interpretation of the corresponding experimental data.

  18. Interference between a fast-paced spatial puzzle task and verbal memory demands.

    Science.gov (United States)

    Epling, Samantha L; Blakely, Megan J; Russell, Paul N; Helton, William S

    2017-06-01

    Research continues to provide evidence that people are poor multi-taskers. Cognitive resource theory is a common explanation for the inability to efficiently perform multiple tasks at the same time. This theory proposes that one's limited supply of cognitive resources can be utilized faster than it is replenished, which results in a performance decline, particularly when these limited resources must be allocated among multiple tasks. Researchers have proposed both domain-specific, for example, spatial versus verbal processing resources, and domain general cognitive resources. In the present research, we investigated whether a spatial puzzle task performed simultaneously with a verbal recall task would impair performance in either task or both tasks, compared to performance on the tasks individually. As hypothesized, a reduction in word recall was found when dual-tasking, though performance on the puzzle task did not significantly differ between the single- and dual-task conditions. This is consistent, in part, with both a general resource theory and a Multiple Resource Theory, but further work is required to better understand the cognitive processing system. The employment of the recall task in the dual-task paradigm with a variety of secondary tasks will help to continue mapping out the specificity (or lack thereof) of cognitive resources utilized in various mental and physical tasks.

  19. Amenorrhea - primary

    Science.gov (United States)

    ... of periods - primary Images Primary amenorrhea Normal uterine anatomy (cut section) Absence of menstruation (amenorrhea) References Bulun SE. The physiology and pathology of the female reproductive axis. In: ...

  20. A puzzle form of a non-verbal intelligence test gives significantly higher performance measures in children with severe intellectual disability.

    Science.gov (United States)

    Bello, Katrina D; Goharpey, Nahal; Crewther, Sheila G; Crewther, David P

    2008-08-01

    Assessment of 'potential intellectual ability' of children with severe intellectual disability (ID) is limited, as current tests designed for normal children do not maintain their interest. Thus a manual puzzle version of the Raven's Coloured Progressive Matrices (RCPM) was devised to appeal to the attentional and sensory preferences and language limitations of children with ID. It was hypothesized that performance on the book and manual puzzle forms would not differ for typically developing children but that children with ID would perform better on the puzzle form. The first study assessed the validity of this puzzle form of the RCPM for 76 typically developing children in a test-retest crossover design, with a 3 week interval between tests. A second study tested performance and completion rate for the puzzle form compared to the book form in a sample of 164 children with ID. In the first study, no significant difference was found between performance on the puzzle and book forms in typically developing children, irrespective of the order of completion. The second study demonstrated a significantly higher performance and completion rate for the puzzle form compared to the book form in the ID population. Similar performance on book and puzzle forms of the RCPM by typically developing children suggests that both forms measure the same construct. These findings suggest that the puzzle form does not require greater cognitive ability but demands sensory-motor attention and limits distraction in children with severe ID. Thus, we suggest the puzzle form of the RCPM is a more reliable measure of the non-verbal mentation of children with severe ID than the book form.

  1. Mobile Technologies in the Service of Students' Learning of Mathematics: The Example of Game Application A.L.E.X. in the Context of a Primary School in Cyprus

    Science.gov (United States)

    Kyriakides, Andreas O.; Meletiou-Mavrotheris, Maria; Prodromou, Theodosia

    2016-01-01

    This article reports on the main experiences gained from a 2-year study which incorporated A.L.E.X., an educational puzzle game available on iPad or Android tablet devices, within the primary school mathematics curriculum. The study took place in a public primary school, located in a rural area of Cyprus. The majority of its students come from low…

  2. An Effective Method of Introducing the Periodic Table as a Crossword Puzzle at the High School Level

    Science.gov (United States)

    Joag, Sushama D.

    2014-01-01

    A simple method to introduce the modern periodic table of elements at the high school level as a game of solving a crossword puzzle is presented here. A survey to test the effectiveness of this new method relative to the conventional method, involving use of a wall-mounted chart of the periodic table, was conducted on a convenience sample. This…

  3. Immature stages and phylogenetic importance of Astrapaeus, a rove beetle genus of puzzling systematic position (Coleoptera, Staphylinidae, Staphylinini)

    NARCIS (Netherlands)

    Pietrykowska-Tudruj, E.; Staniec, B.; Wojas, T.; Alexey, A.

    2014-01-01

    For the first time eggs, larvae and pupae obtained by rearing are described for Astrapaeus, a monotypic West Palearctic rove beetle genus of a puzzling phylogenetic position within the megadiverse tribe Staphylinini. Morphology of the immature stages of Astrapaeus ulmi is compared to that of other

  4. Pengaruh Model Pembelajaran Kooperatif Tipe Time Token Berbantu Puzzle Terhadap Kemampuan Berpikir Kritis Peserta Didik Kelas X Pada Materi Gelombang

    Directory of Open Access Journals (Sweden)

    Sri Latifah

    2015-04-01

    Full Text Available The purpose in this research is to know the influence of cooperative Learning Models Time Type Token with puzzle toward critical thought abilityof the students grade X on Wave material at MA Al Hikmah Bandar Lampung year2014/2015 This research is quantitative with quasi experiment. Reasearch design that used is Nonequivalent Control Group Design with the population of all the students in grade X semestre even at MA Al Hikmah, Bandar Lampung year 2014/2015. The Sample of this research are used 2 classes; experiment and control class, where as experiment class (XA used cooperative time type token model with puzzle and control class (XB used cooperative learning model with pictures as media. Data colecting is using test (pretest and posttest, observation and documentation. After the data test collected, then it is analyzed by using normality test of statistic analysis, homoginity test and test-t. According to the result, it can be concluded that time type token with puzzle application influence significantly ttoward the ability of critical thinking of the students on Wave material at MA Al Hikmah Bandar Lampung year 2014/2015. Tujuan penelitian ini adalah untuk mengetahui pengaruh model pembelajaran kooperatif tipe time token berbantu puzzle terhadap kemampuan berpikir kritis peserta didik kelas X pada materi Gelombang di MA Al Hikmah Bandar Lampung Tahun Pelajaran 2014/2015 .Penelitian ini termasuk kedalam penelitian kuantitatif dengan jenis penelitian Quasi Eksperimen. Desain penelitian ini menggunakan Nonequivalent Control Group Design dengan populasi yaitu seluruh peserta didik kelas X semester genap di MA Al Hikmah Bandar Lampung T.P 2014/2015. Sampel penelitian ini menggunakan 2 kelas yaitu kelas eksperimen dan kontrol, dimana kelas eksperimen (XA menggunakan model kooperatif tipe time token berbantu puzzle dan kelas kontrol (XB menggunakan model pembelajaran kooperatif media gambar. Teknik pengambilan data menggunakan test (pretest dan

  5. Future strategy and puzzles of heavy ion beam mediated technique in genetic improvement of biological bodies

    International Nuclear Information System (INIS)

    Huang Qunce

    2007-01-01

    The 7 research puzzles in the genetic improvement of biological bodies made by ion beam mediated technique, are worth noticed. The technical ideas, including one mediated technique in physics, 2 significant subjects, 3 effective changes, the mediated evidences of 4 aspects and 5 biological characteristics, were particularly put forward according to the existing states in the field. The 2 significant subjects consist of the mechanics of the allogenetic materials entering into the acceptor and they being to be recombined. The 3 effective changes include from studying morphology to genetic laws, from researching M1 generation to the next generations, from determining the single character to the synthetic traits. The mediated evidences of 4 aspects come from morphology, physiology and biochemistry, molecule biology. The 5 biological characteristics are mainly reproduction, development, photosynthesis, bad condition-resistant and quality. (authors)

  6. Well-Defined Cyclic Triblock Terpolymers: A Missing Piece of the Morphology Puzzle

    KAUST Repository

    Polymeropoulos, George

    2016-10-27

    Two well-defined cyclic triblock terpolymers, missing pieces of the terpolymer morphology puzzle, consisting of poly(isoprene), polystyrene, and poly(2-vinylpyridine), were synthesized by combining the Glaser coupling reaction with anionic polymerization. An α,ω-dihydroxy linear triblock terpolymer (OH-PI1,4-b-PS-b-P2VP-OH) was first synthesized followed by transformation of the OH to alkyne groups by esterification with pentynoic acid and cyclization by Glaser coupling. The size exclusion chromatography (SEC) trace of the linear terpolymer precursor was shifted to lower elution time after cyclization, indicating the successful synthesis of the cyclic terpolymer. Additionally, the SEC trace of the cyclic terpolymer produced, after cleavage of the ester groups, shifted again practically to the position corresponding to the linear precursor. The first exploratory results on morphology showed the tremendous influence of the cyclic structure on the morphology of terpolymers. © 2016 American Chemical Society.

  7. Gold-nanoparticle-mediated jigsaw-puzzle-like assembly of supersized plasmonic DNA origami.

    Science.gov (United States)

    Yao, Guangbao; Li, Jiang; Chao, Jie; Pei, Hao; Liu, Huajie; Zhao, Yun; Shi, Jiye; Huang, Qing; Wang, Lianhui; Huang, Wei; Fan, Chunhai

    2015-03-02

    DNA origami has rapidly emerged as a powerful and programmable method to construct functional nanostructures. However, the size limitation of approximately 100 nm in classic DNA origami hampers its plasmonic applications. Herein, we report a jigsaw-puzzle-like assembly strategy mediated by gold nanoparticles (AuNPs) to break the size limitation of DNA origami. We demonstrated that oligonucleotide-functionalized AuNPs function as universal joint units for the one-pot assembly of parent DNA origami of triangular shape to form sub-microscale super-origami nanostructures. AuNPs anchored at predefined positions of the super-origami exhibited strong interparticle plasmonic coupling. This AuNP-mediated strategy offers new opportunities to drive macroscopic self-assembly and to fabricate well-defined nanophotonic materials and devices. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Simon`s Puzzle: Heuristics in the Process of Making Political Choices

    Directory of Open Access Journals (Sweden)

    Mateusz Wajzer

    2014-07-01

    Full Text Available In this article we analyse one of the most fascinating paradoxes of mass politics. Based on the data from the studies of neurobiologists, neurologists, social psychology, cognitive and evolution studies we answer the question specified in literature as the Simon’s puzzle: How is it possible that citizens have their opinions about politics, if they know so little about it? We began our analysis from the criticism of the economic rationality approach. To do this, we referred to the Allais paradox, cognitive dissonance theory, Ellsberg paradox, the concept of bounded rationality, conjunction fallacy and prospect theory. Next, we described the evolutionary processes shaping the minds of Homo sapiens and characterised cognitive mechanisms, thanks to which people can make political choices, especially in view of the shortage of time and information. The following heuristics are referred to herein: affect, recognition, judgment and imitation.

  9. A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells.

    Science.gov (United States)

    Higaki, Takumi; Kutsuna, Natsumaro; Akita, Kae; Takigawa-Imamura, Hisako; Yoshimura, Kenji; Miura, Takashi

    2016-04-01

    Plant leaf epidermal cells exhibit a jigsaw puzzle-like pattern that is generated by interdigitation of the cell wall during leaf development. The contribution of two ROP GTPases, ROP2 and ROP6, to the cytoskeletal dynamics that regulate epidermal cell wall interdigitation has already been examined; however, how interactions between these molecules result in pattern formation remains to be elucidated. Here, we propose a simple interface equation model that incorporates both the cell wall remodeling activity of ROP GTPases and the diffusible signaling molecules by which they are regulated. This model successfully reproduces pattern formation observed in vivo, and explains the counterintuitive experimental results of decreased cellulose production and increased thickness. Our model also reproduces the dynamics of three-way cell wall junctions. Therefore, this model provides a possible mechanism for cell wall interdigitation formation in vivo.

  10. Puzzle test: A tool for non-analytical clinical reasoning assessment.

    Science.gov (United States)

    Monajemi, Alireza; Yaghmaei, Minoo

    2016-01-01

    Most contemporary clinical reasoning tests typically assess non-automatic thinking. Therefore, a test is needed to measure automatic reasoning or pattern recognition, which has been largely neglected in clinical reasoning tests. The Puzzle Test (PT) is dedicated to assess automatic clinical reasoning in routine situations. This test has been introduced first in 2009 by Monajemi et al in the Olympiad for Medical Sciences Students.PT is an item format that has gained acceptance in medical education, but no detailed guidelines exist for this test's format, construction and scoring. In this article, a format is described and the steps to prepare and administer valid and reliable PTs are presented. PT examines a specific clinical reasoning task: Pattern recognition. PT does not replace other clinical reasoning assessment tools. However, it complements them in strategies for assessing comprehensive clinical reasoning.

  11. Shared Environment Estimates for Educational Attainment: A Puzzle and Possible Solutions.

    Science.gov (United States)

    Freese, Jeremy; Jao, Yu-Han

    2017-02-01

    Classical behavioral genetics models for twin and other family designs decompose traits into heritability, shared environment, and nonshared environment components. Estimates of heritability of adult traits are pervasively observed to be far higher than those of shared environment, which has been used to make broad claims about the impotence of upbringing. However, the most commonly studied nondemographic variable in many areas of social science, educational attainment, exhibits robustly high estimates both for heritability and for shared environment. When previously noticed, the usual explanation has emphasized family resources, but evidence suggests this is unlikely to explain the anomalous high estimates for shared environment of educational attainment. We articulate eight potential complementary explanations and discuss evidence of their prospective contributions to resolving the puzzle. In so doing, we hope to further consideration of how behavioral genetics findings may advance studies of social stratification beyond the effort to articulate specific genetic influences. © 2015 Wiley Periodicals, Inc.

  12. The deuteron-radius puzzle is alive: A new analysis of nuclear structure uncertainties

    Science.gov (United States)

    Hernandez, O. J.; Ekström, A.; Nevo Dinur, N.; Ji, C.; Bacca, S.; Barnea, N.

    2018-03-01

    To shed light on the deuteron radius puzzle we analyze the theoretical uncertainties of the nuclear structure corrections to the Lamb shift in muonic deuterium. We find that the discrepancy between the calculated two-photon exchange correction and the corresponding experimentally inferred value by Pohl et al. [1] remain. The present result is consistent with our previous estimate, although the discrepancy is reduced from 2.6 σ to about 2 σ. The error analysis includes statistic as well as systematic uncertainties stemming from the use of nucleon-nucleon interactions derived from chiral effective field theory at various orders. We therefore conclude that nuclear theory uncertainty is more likely not the source of the discrepancy.

  13. Refraining from terror: the puzzle of non violence in Western Sahara

    Directory of Open Access Journals (Sweden)

    Matthew Porges

    2018-02-01

    Full Text Available In Western Sahara, the former Spanish colony occupied by Morocco since 1975, virtually no violent resistance has been mounted by the indigenous Sahrawi people since the end of the 1975-1991 war between Morocco and the pro-independence Polisario Front. This absence of violence is puzzling in the light of several factors: the widespread public support for independence; the social and economic disparities between Moroccan and Sahrawi inhabitants of the territory; and Morocco’s brutal repression of Sahrawi culture, resistance, and expressions of proindependence feeling. This article examines the logic of violence (and its absence and of resistance, and draws lessons from Western Sahara. As well as advancing theoretical development, the article makes a methodological contribution to the study of resistance, and improves our understanding of the Western Sahara conflict through fieldwork, including around 60 interviews with Sahrawi activists conducted in the summer of 2014.

  14. From near to eternity: Spin-glass planting, tiling puzzles, and constraint-satisfaction problems

    Science.gov (United States)

    Hamze, Firas; Jacob, Darryl C.; Ochoa, Andrew J.; Perera, Dilina; Wang, Wenlong; Katzgraber, Helmut G.

    2018-04-01

    We present a methodology for generating Ising Hamiltonians of tunable complexity and with a priori known ground states based on a decomposition of the model graph into edge-disjoint subgraphs. The idea is illustrated with a spin-glass model defined on a cubic lattice, where subproblems, whose couplers are restricted to the two values {-1 ,+1 } , are specified on unit cubes and are parametrized by their local degeneracy. The construction is shown to be equivalent to a type of three-dimensional constraint-satisfaction problem known as the tiling puzzle. By varying the proportions of subproblem types, the Hamiltonian can span a dramatic range of typical computational complexity, from fairly easy to many orders of magnitude more difficult than prototypical bimodal and Gaussian spin glasses in three space dimensions. We corroborate this behavior via experiments with different algorithms and discuss generalizations and extensions to different types of graphs.

  15. The puzzling assembly of the Milky Way halo – contributions from dwarf Spheroidals and globular clusters

    Directory of Open Access Journals (Sweden)

    Lépine S.

    2012-02-01

    Full Text Available While recent sky surveys have uncovered large numbers of ever fainter Milky Way satellites, their classification as star clusters, low-luminosity galaxies, or tidal overdensities remains often unclear. Likewise, their contributions to the build-up of the halo is yet debated. In this contribution we will discuss the current knowledge of the stellar populations and chemo-dynamics in these puzzling satellites, with a particular focus on dwarf spheroidal galaxies and the globular clusters in the outer Galactic halo. Also the question of whether some of the outermost halo objects are dynamically associated with the (Milky Way halo at all is addressed in terms of proper measurements in the remote Leo I and II dwarf galaxies.

  16. Flaxion: a minimal extension to solve puzzles in the standard model

    Energy Technology Data Exchange (ETDEWEB)

    Ema, Yohei [Department of Physics,The University of Tokyo, Tokyo 133-0033 (Japan); Hamaguchi, Koichi; Moroi, Takeo; Nakayama, Kazunori [Department of Physics,The University of Tokyo, Tokyo 133-0033 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU),University of Tokyo, Kashiwa 277-8583 (Japan)

    2017-01-23

    We propose a minimal extension of the standard model which includes only one additional complex scalar field, flavon, with flavor-dependent global U(1) symmetry. It not only explains the hierarchical flavor structure in the quark and lepton sector (including neutrino sector), but also solves the strong CP problem by identifying the CP-odd component of the flavon as the QCD axion, which we call flaxion. Furthermore, the flaxion model solves the cosmological puzzles in the standard model, i.e., origin of dark matter, baryon asymmetry of the universe, and inflation. We show that the radial component of the flavon can play the role of inflaton without isocurvature nor domain wall problems. The dark matter abundance can be explained by the flaxion coherent oscillation, while the baryon asymmetry of the universe is generated through leptogenesis.

  17. Towards a solution of the puzzle posed by superconducting SrTiO3

    Science.gov (United States)

    Malik, G. P.

    2015-09-01

    Suitably doped SrTiO3 was found in 1964 to undergo a superconducting transition below 1 K with a dome-like Tc versus n (electron concentration) plot. The apex of the dome — a point of inflection — corresponds to the point (n≈9 ×1019cm-3, Tc≈0.30 K). On either side of it, Tc goes down to ≈0.1 K for the extreme values between which n was varied. A single value of Tc is thus observed for two different values of n. The puzzle for the theory has been to explain this result. Treating the problem in all its generality, we present here three equations: the μ1-incorporated BCS equation for Tc, the μ0-incorporated equation for the T = 0 gap Δ0, where μ1 and μ0 are the chemical potentials at T = Tc and T = 0 respectively, and an equation that relates the interaction parameters λ1 and λ0 at these temperatures. Because there are five unknowns in the problem, we tackle these equations via an approximation scheme that includes setting μ1 = μ0 and λ1 = λ0. The latter of these is factually a basic tenet of the BCS theory. Salient features of our findings are: (i) the solutions for Tc and Δ0 on the RHS (LHS) of the dome correspond to μ> kBθD(μ LHS the limits of the integrals in the equations need to be curtailed to obtain real solutions and (iii) the point μ = kBθD is a point of inflection in the Tc versus μ plot. Since the puzzle has remained unsolved for a long time, we also offer here a purely mathematical model for λ(μ) — sans physical justification — which leads to a Tc versus μ plot qualitatively in agreement with experiment.

  18. Box-Cox transformation for resolving Peelle's Pertinent Puzzle in curve fitting

    International Nuclear Information System (INIS)

    Oh, Soo-Youl

    2003-01-01

    Incorporating the Box-Cox transformation into a least-squares method is presented as one of resolutions of an anomaly known as Peelle's Pertinent Puzzle. The transformation is a strategy to make non-normal distribution data resemble normal data. A procedure is proposed: transform the measured raw data with an optimized Box-Cox transformation parameter, fit the transformed data using a usual curve fitting method, then inverse-transform the fitted results to final estimates. The generalized least-squares method utilized in GMA is adopted as the curve fitting tool for the test of proposed procedure. In the procedure, covariance matrices are correspondingly transformed and inverse-transformed with the aid of error propagation law. In addition to a sensible answer to the Peelle's problem itself, the procedure resulted in reasonable estimates of 6 Li(n,t) cross sections in several to 800 keV energy region. Meanwhile, comparisons of the present procedure with that of Chiba and Smith show that both procedures yield estimates so close each other for the sample evaluation on 6 Li(n,t) above as well as for the Peelle's problem. Two procedures, however, are conceptually very different and further discussions would be needed for a consensus on this issue of resolving the Puzzle. It is also pointed out that the transformation is applicable not only to a least-squares method but also to other parameter estimation method such as a usual Bayesian approach formulated with an assumption of normality of the probability density function. (author)

  19. Desain Pembelajaran Bangun Datar Menggunakan Fable “Dog Catches Cat” And Puzzle Tangram Di Kelas II SD

    Directory of Open Access Journals (Sweden)

    Lisnani Lisnani

    2013-06-01

    Full Text Available Tujuan penelitian ini adalah mengembangkan kemampuan berpikir kreatif matematis siswa dalam pengenalan dan pengelompokkan bangun datar melalui fable “dog catches cat”, puzzle tangram, dan kreasi origami. Metode yang digunakan adalah design research terdiri dari tiga tahap, yaitu: preliminary, design experiment (pilot experiment dan teaching experiment, dan analysis retrospective.  Penelitian ini mengembangkan hasil pembelajaran tentang bangun datar melalui serangkaian aktivitas, prosedur, dan strategi bagi siswa dalam menemukan kemampuan berpikir kreatif melalui Pendekatan Pendidikan Matematika Realistik Indonesia (PMRI melalui konteks tangram melalui fable “dog catches cat”. Puzzle tangram, dan kreasi origami menjadi starting point materi pengenalan dan pengelompokkan bangun datar. Hasil dari penelitian ini berupa learning trajectory pada masing-masing aktivitas yaitu: 1 Aktivitas 1, siswa mengenal berbagai bentuk bangun datar melalui penggunaan fable. 2 Aktivitas 2, siswa mampu menyebutkan dan mengelompokkan berbagai bangun datar melalui puzzle tangram. 3 Aktivitas 3, membentuk dan mengelompokkan bangun datar dan terbentuk suatu kreasi baru berupa kucing, anjing, dan lainnya.The purpose of this research is to develop mathematical creative thinking abilities and grouping students in the introduction of a flat wake through the fable “dog catches paint " , tangram puzzles, and origami creations. The method used is the research design consists of three stages: preliminary, design of experiments (pilot experiments and teaching experiments, and a retrospective analysis. This study develops learning outcomes on a flat wake through a series of activities, procedures, and strategies for students in finding creative thinking abilities through Realistic Mathematics Education Approach Indonesia (PMRI through tangram context through fable “dog catches the paint “. Tangram puzzles, and origami creations become the starting point and the

  20. Cles: Etes-vous bon detective?; Enigmes grammaticales; Problemes policiers; Kidnapping (Keys: Are You a Good Detective?; Grammatical Puzzles; Detective Mysteries; Kidnapping).

    Science.gov (United States)

    Debyser, Francis; And Others

    1984-01-01

    Four sets of French classroom activities are presented: a mystery whose clues include two postcard messages; three puzzles with grammar-related clues; a mystery contained in three comic strip frames; and the solving of a kidnapping mystery. (MSE)

  1. A solution to the rho-π puzzle: Spontaneously broken symmetries of the quark model

    International Nuclear Information System (INIS)

    Caldi, D.G.; Pagels, H.

    1976-01-01

    This article proposes a solution to the long-standing rho-π puzzle: How can the rho and π be members of a quark model U(6) 36 and the π be a Nambu-Goldstone boson satisfying partial conservation of the axial-vector current (PCAC) Our solution to the puzzle requires a revision of conventional concepts regarding the vector mesons rho, ω, K*, and phi. Just as the π is a Goldstone state, a collective excitation of the Nambu--Jona-Lasinio type, transforming as a member of the (3, 3) + (3, 3) representation of the chiral SU(3) x SU(3) group, so also the rho transforms like (3, 3) + (3, 3) and is also a collective state, a ''dormant'' Goldstone boson that is a true Goldstone boson in the static chiral U(6) x U(6) limit. The static chiral U(6) x U(6) is to be spontaneously broken to static U(6) in the vacuum. Relativisitc effects provide for U(6) breaking and a massive rho. This viewpoint has many consequences. Vector-meson dominance is a consequence of spontaneously broken chiral symmetry: the mechanism that couples the axial-vector current to the π couples the vector current to the rho. The transition rate is calculated as γ/sub rho/ -1 = f/sub pi//m/sub rho/ in rough agreement with experiment. This picture requires soft rho's to decouple. The chiral partner of the rho is not the A 1 but the B (1235). The experimental absence of the A 1 is no longer a theoretical embarrassment in this scheme. As the analog of PCAC for the pion we establish a tensor-field identity for the rho meson in which the rho is interpreted as a dormant Goldstone state. The decays delta → eta + π, B → ω + π, epsilon → 2π are estimated and are found to be in agreement with the observed rates. A static U(6) x U(6) generalization of the Σ model is presented with the π, rho, sigma, B in the (6, 6) + (6, 6) representation. The rho emerges as a dormant Goldstone boson in this model

  2. The B→πK puzzle and its relation to rare B and K decays

    International Nuclear Information System (INIS)

    Buras, A.J.; Recksiegel, S.; Fleischer, R.; Schwab, F.

    2003-01-01

    The standard-model interpretation of the ratios of charged and neutral B→πK rates, R c and R n , respectively, points towards a puzzling picture. Since these observables are affected significantly by colour-allowed electroweak (EW) penguins, this ''B→πK puzzle'' could be a manifestation of new physics in the EW penguin sector. Performing the analysis in the R n - R c plane, which is very suitable for monitoring various effects, we demonstrate that we may, in fact, move straightforwardly to the experimental region in this plane through an enhancement of the relevant EW penguin parameter q. We derive analytical bounds for q in terms of a quantity L, which measures the violation of the Lipkin sum rule, and point out that strong phases around 90 circle are favoured by the data, in contrast to QCD factorisation. The B→πK modes imply a correlation between q and the angle γ that, in the limit of negligible rescattering effects and colour-suppressed EW penguins, depends only on the value of L. Concentrating on a minimal flavour-violating new-physics scenario with enhanced Z 0 penguins, we find that the current experimental values on B→X s μ + μ - require roughly L≤1.8. As the B→πK data give L = 5.7±2.4, L has either to move to smaller values once the B→πK data improve or new sources of flavour and CP violation are needed. In turn, the enhanced values of L seen in the B→πK data could be accompanied by enhanced branching ratios for the rare decays K + →π + νanti ν, K L →π 0 e + e - , B→X s νanti ν and B s,d →μ + μ - . Most interesting turns out to be the correlation between the B→πK modes and BR (K + →π + νanti ν), with the latter depending approximately on a single ''scaling'' variable anti L = L.(vertical stroke V ub /V cb vertical stroke /0.086) 2.3 . (orig.)

  3. Two approaches towards the flavour puzzle. Dynamical minimal flavour violation and warped extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Michaela E.

    2010-08-16

    The minimal-flavour-violating (MFV) hypothesis considers the Standard Model (SM) Yukawa matrices as the only source of flavour violation. In this work, we promote their entries to dynamical scalar spurion fields, using an effective field theory approach, such that the maximal flavour symmetry (FS) of the SM gauge sector is formally restored at high energy scales. The non-vanishing vacuum expectation values of the spurions induce a sequence of FS breaking and generate the observed hierarchy in the SM quark masses and mixings. The fact that there exists no explanation for it in the SM is known as the flavour puzzle. Gauging the non-abelian subgroup of the spontaneously broken FS, we interpret the associated Goldstone bosons as the longitudinal degrees of freedom of the corresponding massive gauge bosons. Integrating out the heavy Higgs modes in the Yukawa spurions leads directly to flavour-changing neutral currents (FCNCs) at tree level. The coefficients of the effective four-quark operators, resulting from the exchange of heavy flavoured gauge bosons, strictly follow the MFV principle. On the other hand, the Goldstone bosons associated with the global abelian symmetry group behave as weakly coupled axions which can be used to solve the strong CP problem within a modified Peccei-Quinn formalism. Models with a warped fifth dimension contain five-dimensional (5D) fermion bulk mass matrices in addition to their 5D Yukawa matrices, which thus represent an additional source of flavour violation beyond MFV. They can address the flavour puzzle since their eigenvalues allow for a different localisation of the fermion zero mode profiles along the extra dimension which leads to a hierarchy in the effective four-dimensional (4D) Yukawa matrices. At the same time, the fermion splitting introduces non-universal fermion couplings to Kaluza-Klein (KK) gauge boson modes, inducing tree-level FCNCs. Within a Randall-Sundrum model with custodial protection (RSc model) we carefully work

  4. Two approaches towards the flavour puzzle. Dynamical minimal flavour violation and warped extra dimensions

    International Nuclear Information System (INIS)

    Albrecht, Michaela E.

    2010-01-01

    The minimal-flavour-violating (MFV) hypothesis considers the Standard Model (SM) Yukawa matrices as the only source of flavour violation. In this work, we promote their entries to dynamical scalar spurion fields, using an effective field theory approach, such that the maximal flavour symmetry (FS) of the SM gauge sector is formally restored at high energy scales. The non-vanishing vacuum expectation values of the spurions induce a sequence of FS breaking and generate the observed hierarchy in the SM quark masses and mixings. The fact that there exists no explanation for it in the SM is known as the flavour puzzle. Gauging the non-abelian subgroup of the spontaneously broken FS, we interpret the associated Goldstone bosons as the longitudinal degrees of freedom of the corresponding massive gauge bosons. Integrating out the heavy Higgs modes in the Yukawa spurions leads directly to flavour-changing neutral currents (FCNCs) at tree level. The coefficients of the effective four-quark operators, resulting from the exchange of heavy flavoured gauge bosons, strictly follow the MFV principle. On the other hand, the Goldstone bosons associated with the global abelian symmetry group behave as weakly coupled axions which can be used to solve the strong CP problem within a modified Peccei-Quinn formalism. Models with a warped fifth dimension contain five-dimensional (5D) fermion bulk mass matrices in addition to their 5D Yukawa matrices, which thus represent an additional source of flavour violation beyond MFV. They can address the flavour puzzle since their eigenvalues allow for a different localisation of the fermion zero mode profiles along the extra dimension which leads to a hierarchy in the effective four-dimensional (4D) Yukawa matrices. At the same time, the fermion splitting introduces non-universal fermion couplings to Kaluza-Klein (KK) gauge boson modes, inducing tree-level FCNCs. Within a Randall-Sundrum model with custodial protection (RSc model) we carefully work

  5. 15C-15F Charge Symmetry and the 14C(n,γ)15C Reaction Puzzle

    International Nuclear Information System (INIS)

    Timofeyuk, N.K.; Thompson, I.J.; Baye, D.; Descouvemont, P.; Kamouni, R.

    2006-01-01

    The low-energy reaction 14 C(n,γ) 15 C provides a rare opportunity to test indirect methods for the determination of neutron capture cross sections by radioactive isotopes versus direct measurements. It is also important for various astrophysical scenarios. Currently, puzzling disagreements exist between the 14 C(n,γ) 15 C cross sections measured directly, determined indirectly, and calculated theoretically. To solve this puzzle, we offer a strong test based on a novel idea that the amplitudes for the virtual 15 C→ 14 C+n and the real 15 F→ 14 O+p decays are related. Our study of this relation, performed in a microscopic model, shows that existing direct and some indirect measurements strongly contradict charge symmetry in the 15 C and 15 F mirror pair. This brings into question the experimental determinations of the astrophysically important (n,γ) cross sections for short-lived radioactive targets

  6. Penerapan Model Aktive Learning dengan Metode Crossword Puzzle dalam Pembelajaran Ekonomi Kelas X pada Sman 10 Pontianak

    OpenAIRE

    Susiana, Elis

    2017-01-01

    The purpose of this study is to determine the effectiveness of the implementation of Active Learning model with Crossword Puzzle method in the learning of class X economics at SMAN 10 Pontianak. The method used in this research is the experimental method with the experimental quasi-experimental design with the design of time series research design. The subjects in this study are students of class XE SMAN 10 Pontianak with 39 students. Data collection techniques used are direct observation tec...

  7. Primary explosives

    Energy Technology Data Exchange (ETDEWEB)

    Matyas, Robert; Pachman, Jiri [Pardubice Univ. (Czech Republic). Faculty of Chemical Technology

    2013-06-01

    The first chapter provides background such as the basics of initiation and differences between requirements on primary explosives used in detonators and igniters. The authors then clarify the influence of physical characteristics on explosive properties, focusing on those properties required for primary explosives. Furthermore, the issue of sensitivity is discussed. All the chapters on particular groups of primary explosives are structured in the same way, including introduction, physical and chemical properties, explosive properties, preparation and documented use.

  8. Changes in food intake and abnormal behavior using a puzzle feeder in newly acquired sub-adult rhesus monkeys (Macaca mulatta): a short term study.

    Science.gov (United States)

    Lee, Jae-Il; Lee, Chi-Woo; Kwon, Hyouk-Sang; Kim, Young-Tae; Park, Chung-Gyu; Kim, Sang-Joon; Kang, Byeong-Cheol

    2008-10-01

    The majority of newly acquired nonhuman primates encounter serious problems adapting themselves to new environments or facilities. In particular, loss of appetite and abnormal behavior can occur in response to environmental stresses. These adaptation abnormalities can ultimately have an affect on the animal's growth and well-being. In this study, we evaluated the affects of a puzzle feeder on the food intake and abnormal behavior of newly acquired rhesus monkeys for a short period. The puzzle feeder was applied to 47- to 58-month-old animals that had never previously encountered one. We found that there was no difference in the change of food intake between the bucket condition and the puzzle feeder condition. In contrast, the time spent for consumption of food was three times longer in the puzzle feeder condition than in the bucket condition. Two monkeys initially exhibited stereotypic behavior. One showed a decreasing, and the other an increasing pattern of abnormal behavior after introduction of the puzzle feeder. In conclusion, this result suggests that over a short period, the puzzle feeder can only affect the time for food consumption since it failed to affect the food intake and did not consistently influence stereotypic behaviors in newly acquired rhesus monkeys.

  9. Ratio of hadronic decay rates of J/ψ and ψ(2S) and the ρπ puzzle

    International Nuclear Information System (INIS)

    Gu, Y. F.; Li, X. H.

    2001-01-01

    The so-called ρπ puzzle of J/ψ and ψ(2S) decays is examined using the experimental data available to date. Two different approaches were taken to estimate the ratio of J/ψ and ψ(2S) hadronic decay rates. While one of the estimates could not yield the exact ratio of ψ(2S) to J/ψ inclusive hadronic decay rates, the other, based on a computation of the inclusive ggg decay rate for ψ(2S)(J/ψ) by subtracting other decay rates from the total decay rate, differs by two standard deviations from the naive prediction of perturbative QCD, even though its central value is nearly twice as large as what was naively expected. A comparison between this ratio, upon making corrections for specific exclusive two-body decay modes, and the corresponding experimental data confirms the puzzles in J/ψ and ψ(2S) decays. We find from our analysis that the exclusively reconstructed hadronic decays of the ψ(2S) account for only a small fraction of its total decays, and a ratio exceeding the above estimate should be expected to occur for a considerable number of the remaining decay channels. We also show that the recent new results from the BES experiment provide crucial tests of various theoretical models proposed to explain the puzzle

  10. Primary fibromyalgia

    DEFF Research Database (Denmark)

    Jacobsen, S; Jensen, L T; Foldager, M

    1990-01-01

    Serum concentrations of procollagen type III aminoterminal peptide have previously been reported to be low in some patients with primary fibromyalgia and the aim of this study was to determine if such patients differ clinically from primary fibromyalgia patients with normal levels of procollagen...... type III aminoterminal peptide. Subjective symptoms, tender points and dynamic muscle strength in 45 women with primary fibromyalgia were related to serum concentrations of procollagen type III aminoterminal peptide. Patients with low serum concentrations of procollagen type III aminoterminal peptide...... concentrations of procollagen type III aminoterminal peptide of primary fibromyalgia patients are connected to the disease impact....

  11. Learning and Memory Processes Following Cochlear Implantation:The Missing Piece of the Puzzle

    Directory of Open Access Journals (Sweden)

    David B. Pisoni

    2016-04-01

    Full Text Available At the present time, there is no question that cochlear implants work and often work very well in quiet listening conditions for many profoundly deaf children and adults. The speech and language outcomes data published over the last two decades document quite extensively the clinically significant benefits of cochlear implants. Although there now is a large body of evidence supporting the efficacy of cochlear implants as a medical intervention for profound hearing loss in both children and adults, there still remain a number of challenging unresolved clinical and theoretical issues that deal with the effectiveness of cochlear implants in individual patients that have not yet been successfully resolved. In this paper, we review recent findings on learning and memory, two central topics in the field of cognition that have been seriously neglected in research on cochlear implants. Our research findings on sequence learning, memory and organization processes, and retrieval strategies used in verbal learning and memory of categorized word lists suggests that basic domain-general learning abilities may be the missing piece of the puzzle in terms of understanding the cognitive factors that underlie the enormous individual differences and variability routinely observed in speech and language outcomes following cochlear implantation.

  12. Physics and financial economics (1776-2014): puzzles, Ising and agent-based models

    Science.gov (United States)

    Sornette, Didier

    2014-06-01

    This short review presents a selected history of the mutual fertilization between physics and economics—from Isaac Newton and Adam Smith to the present. The fundamentally different perspectives embraced in theories developed in financial economics compared with physics are dissected with the examples of the volatility smile and of the excess volatility puzzle. The role of the Ising model of phase transitions to model social and financial systems is reviewed, with the concepts of random utilities and the logit model as the analog of the Boltzmann factor in statistical physics. Recent extensions in terms of quantum decision theory are also covered. A wealth of models are discussed briefly that build on the Ising model and generalize it to account for the many stylized facts of financial markets. A summary of the relevance of the Ising model and its extensions is provided to account for financial bubbles and crashes. The review would be incomplete if it did not cover the dynamical field of agent-based models (ABMs), also known as computational economic models, of which the Ising-type models are just special ABM implementations. We formulate the ‘Emerging Intelligence Market Hypothesis’ to reconcile the pervasive presence of ‘noise traders’ with the near efficiency of financial markets. Finally, we note that evolutionary biology, more than physics, is now playing a growing role to inspire models of financial markets.

  13. Physics and financial economics (1776–2014): puzzles, Ising and agent-based models

    International Nuclear Information System (INIS)

    Sornette, Didier

    2014-01-01

    This short review presents a selected history of the mutual fertilization between physics and economics—from Isaac Newton and Adam Smith to the present. The fundamentally different perspectives embraced in theories developed in financial economics compared with physics are dissected with the examples of the volatility smile and of the excess volatility puzzle. The role of the Ising model of phase transitions to model social and financial systems is reviewed, with the concepts of random utilities and the logit model as the analog of the Boltzmann factor in statistical physics. Recent extensions in terms of quantum decision theory are also covered. A wealth of models are discussed briefly that build on the Ising model and generalize it to account for the many stylized facts of financial markets. A summary of the relevance of the Ising model and its extensions is provided to account for financial bubbles and crashes. The review would be incomplete if it did not cover the dynamical field of agent-based models (ABMs), also known as computational economic models, of which the Ising-type models are just special ABM implementations. We formulate the ‘Emerging Intelligence Market Hypothesis’ to reconcile the pervasive presence of ‘noise traders’ with the near efficiency of financial markets. Finally, we note that evolutionary biology, more than physics, is now playing a growing role to inspire models of financial markets. (key issues reviews)

  14. The grand unified link between the Peccei-Quinn mechanism and the generation puzzle

    International Nuclear Information System (INIS)

    Davidson, A.; Wali, K.C.

    1982-03-01

    The essential ingredients of the Peccei-Quinn mechanism are shown to be dictated by a proper choice of a grand unification scheme. The presence of U(1)sub(PQ) gives rise to the possibility that the same physics which resolves the strong CP-violation problem may decode the generation puzzle with no extra cost. Multigenerational signatures of the invisible axion scenario, such as the canonical fermion mass matrix, are discussed. The uniqueness and the special values of the quantized PQ-assignments, namely 1,-3,5-7,... for successive generations, acquire an automatic explanation once the idea of ''horizontal compositeness'' is invoked. A characteristic feature then is that the muon appears to have a less complicated structure than the electron. Furthermore, U(1)sub(PQ) chooses SO(10) to be its only tenable gauge symmetry partner, and at the same time crucially restricts the associated Higgs system. All this finally results in a consistent fermion mass hierarchy with log m, to the crudest estimation, varying linearly with respect to the generation index. (author)

  15. Antarctic Temperature Extremes from MODIS Land Surface Temperatures: New Processing Methods Reveal Data Quality Puzzles

    Science.gov (United States)

    Grant, G.; Gallaher, D. W.

    2017-12-01

    New methods for processing massive remotely sensed datasets are used to evaluate Antarctic land surface temperature (LST) extremes. Data from the MODIS/Terra sensor (Collection 6) provides a twice-daily look at Antarctic LSTs over a 17 year period, at a higher spatiotemporal resolution than past studies. Using a data condensation process that creates databases of anomalous values, our processes create statistical images of Antarctic LSTs. In general, the results find few significant trends in extremes; however, they do reveal a puzzling picture of inconsistent cloud detection and possible systemic errors, perhaps due to viewing geometry. Cloud discrimination shows a distinct jump in clear-sky detections starting in 2011, and LSTs around the South Pole exhibit a circular cooling pattern, which may also be related to cloud contamination. Possible root causes are discussed. Ongoing investigations seek to determine whether the results are a natural phenomenon or, as seems likely, the results of sensor degradation or processing artefacts. If the unusual LST patterns or cloud detection discontinuities are natural, they point to new, interesting processes on the Antarctic continent. If the data artefacts are artificial, MODIS LST users should be alerted to the potential issues.

  16. Low-voltage puzzle-like fractal microelectromechanial system variable capacitor suppressing pull-in

    KAUST Repository

    Elshurafa, Amro M.

    2012-10-01

    This Letter introduces an electrostatically actuated fractal MEMS variable capacitor that, by utilising the substrate, extends the tuning range (TR) beyond the theoretical limit of 1.5 as dictated by the pull-in phenomenon. The backbone concept behind the fractal varactor is to create a suspended movable plate possessing a specific fractal geometry, and to simultaneously create a bottom fixed plate complementary in shape to the top plate. Thus, when the top plate is actuated, it moves towards the bottom plate and fills the void present within the bottom plate without touching it akin to how puzzle pieces are assembled. Further, a reasonable horizontal separation is maintained between both the plates to avoid shorting. The electrostatic forces come from the capacitance formed between the top plate and bottom plate, and from the capacitance formed between the top plate and the doped substrate. The variable capacitor was fabricated in the PolyMUMPS process and provided a TR of 4.1 at 6 V, and its resonant frequency was in excess of 40 GHz.

  17. Exosome-Mediated Genetic Information Transfer, a Missing Piece of Osteoblast-Osteoclast Communication Puzzle.

    Science.gov (United States)

    Yin, Pengbin; Lv, Houchen; Li, Yi; Deng, Yuan; Zhang, Licheng; Tang, Peifu

    2017-01-01

    The skeletal system functions and maintains itself based on communication between cells of diverse origins, especially between osteoblasts (OBs) and osteoclasts (OCs), accounting for bone formation and resorption, respectively. Previously, protein-level information exchange has been the research focus, and this has been discussed in detail. The regulative effects of microRNAs (miRNAs) on OB and OC ignite the question as to whether genetic information could be transferred between bone cells. Exosomes, extracellular membrane vesicles 30-100 nm in diameter, have recently been demonstrated to transfer functional proteins, mRNAs, and miRNAs, and serve as mediators of intercellular communication. By reviewing the distinguishing features of exosomes, a hypothesis was formulated and evaluated in this article that exosome-mediated genetic information transfer may represent a novel strategy for OB-OC communication. The exosomes may coordinately regulate these two cells under certain physiological conditions by transferring genetic information. Further research in exosome-shuttered miRNAs in OB-OC communication may add a missing piece to the bone cells communication "puzzle."

  18. The High-Density Lipoprotein Puzzle: Why Classic Epidemiology, Genetic Epidemiology, and Clinical Trials Conflict?

    Science.gov (United States)

    Rosenson, Robert S

    2016-05-01

    Classical epidemiology has established the incremental contribution of the high-density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; yet, genetic epidemiology does not support a causal relationship between HDL cholesterol and the future risk of myocardial infarction. Therapeutic interventions directed toward cholesterol loading of the HDL particle have been based on epidemiological studies that have established HDL cholesterol as a biomarker of atherosclerotic cardiovascular risk. However, therapeutic interventions such as niacin, cholesteryl ester transfer protein inhibitors increase HDL cholesterol in patients treated with statins, but have repeatedly failed to reduce cardiovascular events. Statin therapy interferes with ATP-binding cassette transporter-mediated macrophage cholesterol efflux via miR33 and thus may diminish certain HDL functional properties. Unraveling the HDL puzzle will require continued technical advances in the characterization and quantification of multiple HDL subclasses and their functional properties. Key mechanistic criteria for clinical outcomes trials with HDL-based therapies include formation of HDL subclasses that improve the efficiency of macrophage cholesterol efflux and compositional changes in the proteome and lipidome of the HDL particle that are associated with improved antioxidant and anti-inflammatory properties. These measures require validation in genetic studies and clinical trials of HDL-based therapies on the background of statins. © 2016 American Heart Association, Inc.

  19. Orbital Wall Reconstruction with Two-Piece Puzzle 3D Printed Implants: Technical Note

    Science.gov (United States)

    Mommaerts, Maurice Y.; Büttner, Michael; Vercruysse, Herman; Wauters, Lauri; Beerens, Maikel

    2015-01-01

    The purpose of this article is to describe a technique for secondary reconstruction of traumatic orbital wall defects using titanium implants that act as three-dimensional (3D) puzzle pieces. We present three cases of large defect reconstruction using implants produced by Xilloc Medical B.V. (Maastricht, the Netherlands) with a 3D printer manufactured by LayerWise (3D Systems; Heverlee, Belgium), and designed using the biomedical engineering software programs ProPlan and 3-Matic (Materialise, Heverlee, Belgium). The smaller size of the implants allowed sequential implantation for the reconstruction of extensive two-wall defects via a limited transconjunctival incision. The precise fit of the implants with regard to the surrounding ledges and each other was confirmed by intraoperative 3D imaging (Mobile C-arm Systems B.V. Pulsera, Philips Medical Systems, Eindhoven, the Netherlands). The patients showed near-complete restoration of orbital volume and ocular motility. However, challenges remain, including traumatic fat atrophy and fibrosis. PMID:26889349

  20. Genome puzzle master (GPM): an integrated pipeline for building and editing pseudomolecules from fragmented sequences.

    Science.gov (United States)

    Zhang, Jianwei; Kudrna, Dave; Mu, Ting; Li, Weiming; Copetti, Dario; Yu, Yeisoo; Goicoechea, Jose Luis; Lei, Yang; Wing, Rod A

    2016-10-15

    Next generation sequencing technologies have revolutionized our ability to rapidly and affordably generate vast quantities of sequence data. Once generated, raw sequences are assembled into contigs or scaffolds. However, these assemblies are mostly fragmented and inaccurate at the whole genome scale, largely due to the inability to integrate additional informative datasets (e.g. physical, optical and genetic maps). To address this problem, we developed a semi-automated software tool-Genome Puzzle Master (GPM)-that enables the integration of additional genomic signposts to edit and build 'new-gen-assemblies' that result in high-quality 'annotation-ready' pseudomolecules. With GPM, loaded datasets can be connected to each other via their logical relationships which accomplishes tasks to 'group,' 'merge,' 'order and orient' sequences in a draft assembly. Manual editing can also be performed with a user-friendly graphical interface. Final pseudomolecules reflect a user's total data package and are available for long-term project management. GPM is a web-based pipeline and an important part of a Laboratory Information Management System (LIMS) which can be easily deployed on local servers for any genome research laboratory. The GPM (with LIMS) package is available at https://github.com/Jianwei-Zhang/LIMS CONTACTS: jzhang@mail.hzau.edu.cn or rwing@mail.arizona.eduSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

  1. Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle of motor neuron degeneration.

    Science.gov (United States)

    Castanedo-Vazquez, David; Bosque-Varela, Pilar; Sainz-Pelayo, Arancha; Riancho, Javier

    2018-05-29

    Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons (MN). This fatal disease is characterized by progressive muscle wasting and lacks an effective treatment. ALS pathogenesis has not been elucidated yet. In a small proportion of ALS patients, the disease has a familial origin, related to mutations in specific genes, which directly result in MN degeneration. By contrast, the vast majority of cases are though to be sporadic, in which genes and environment interact leading to disease in genetically predisposed individuals. Lately, the role of the environment has gained relevance in this field and an extensive list of environmental conditions have been postulated to be involved in ALS. Among them, infectious agents, particularly viruses, have been suggested to play an important role in the pathogenesis of the disease. These agents could act by interacting with some crucial pathways in MN degeneration, such as gene processing, oxidative stress or neuroinflammation. In this article, we will review the main studies about the involvement of microorganisms in ALS, subsequently discussing their potential pathogenic effect and integrating them as another piece in the puzzle of ALS pathogenesis.

  2. The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle.

    Science.gov (United States)

    Mitta, G; Gourbal, B; Grunau, C; Knight, M; Bridger, J M; Théron, A

    2017-01-01

    This review reexamines the results obtained in recent decades regarding the compatibility polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma mansoni, which is one of the agents responsible for human schistosomiasis. Some results point to the snail's resistance as explaining the incompatibility, while others support a "matching hypothesis" between the snail's immune receptors and the schistosome's antigens. We propose here that the two hypotheses are not exclusive, and that the compatible/incompatible status of a particular host/parasite couple probably reflects the balance of multiple molecular determinants that support one hypothesis or the other. Because these genes are involved in a coevolutionary arms race, we also propose that the underlying mechanisms can vary. Finally, some recent results show that environmental factors could influence compatibility. Together, these results make the compatibility between B. glabrata and S. mansoni an increasingly complex puzzle. We need to develop more integrative approaches in order to find targets that could potentially be manipulated to control the transmission of schistosomiasis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Learning and Memory Processes Following Cochlear Implantation: The Missing Piece of the Puzzle.

    Science.gov (United States)

    Pisoni, David B; Kronenberger, William G; Chandramouli, Suyog H; Conway, Christopher M

    2016-01-01

    At the present time, there is no question that cochlear implants (CIs) work and often work very well in quiet listening conditions for many profoundly deaf children and adults. The speech and language outcomes data published over the last two decades document quite extensively the clinically significant benefits of CIs. Although there now is a large body of evidence supporting the "efficacy" of CIs as a medical intervention for profound hearing loss in both children and adults, there still remain a number of challenging unresolved clinical and theoretical issues that deal with the "effectiveness" of CIs in individual patients that have not yet been successfully resolved. In this paper, we review recent findings on learning and memory, two central topics in the field of cognition that have been seriously neglected in research on CIs. Our research findings on sequence learning, memory and organization processes, and retrieval strategies used in verbal learning and memory of categorized word lists suggests that basic domain-general learning abilities may be the missing piece of the puzzle in terms of understanding the cognitive factors that underlie the enormous individual differences and variability routinely observed in speech and language outcomes following cochlear implantation.

  4. Low level radioactive waste management in New York State all the pieces of the puzzle, but

    International Nuclear Information System (INIS)

    Gerber, C.A.

    1995-01-01

    Unlike many other states and compacts, New York not only has a volunteer community, but that community has over three thousand acres of state owned land that was intended for commercial nuclear use. A poll conducted by the Siting Commission indicates that the citizens of New York understand the need for a central monitored disposal facility for LLRW. Hundreds of widely dispersed storage sites are unacceptable to the majority of New Yorkers. New York State has a law requiring the siting and construction of a facility for the permanent disposal of LLRW. The regulations are in place and the Siting Commission has gone through the siting process forward, and should be about finished doing it backwards as the amended state law required. The State Health Department has authorized a $800,000 contract to the National Academy of Science to review the process. The representatives of the Cortland County opponents went on record and already stated that the NAS Study is unacceptable. After fifty million dollars the results are catastrophic. The generators in the state will be forced to store their waste because of the failure by the state to obey it's own law. According to the law, the facility was to be in operation no later than January 1, 1993. While New York State has all the pieces of the LLRW management puzzle on the table, there are many people with political and social agendas ready to knock the pieces onto the floor

  5. The mechanism of collagen cross-linking in diabetes: a puzzle nearing resolution.

    Science.gov (United States)

    Monnier, V M; Glomb, M; Elgawish, A; Sell, D R

    1996-07-01

    Considerable interest has been focused in recent years on the mechanism of collagen cross-linking by high glucose in vitro and in vivo. Experiments in both diabetic humans and in animals have shown that over time collagen becomes less soluble, less digestible by collagenase, more stable to heat-induced denaturation, and more glycated. In addition, collagen becomes more modified by advanced products of the Maillard reaction, i.e., immunoreactive advanced glycation end products and the glycoxidation markers carboxymethyllysine and pentosidine. Mechanistic studies have shown that collagen cross-linking in vitro can be uncoupled from glycation by the use of antioxidants and chelating agents. Experiments in the authors' laboratory revealed that approximately 50% of carboxymethyllysine formed in vitro originates from pathways other than oxidation of Amadori products, i.e., most likely the oxidation of Schiff base-linked glucose. In addition, the increase in thermal stability of rat tail tendons exposed to high glucose in vitro or in vivo was found to strongly depend on H2O2 formation. The final missing piece of the puzzle is that of the structure of the major cross-link. We speculate that it is a nonfluorescent nonultraviolet active cross-link between two lysine residues, which includes a fragmentation product of glucose linked in a nonreducible bond labile to both strong acids and bases.

  6. Puzzles in modern biology. IV. Neurodegeneration, localized origin and widespread decay [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Steven A. Frank

    2016-10-01

    Full Text Available The motor neuron disease amyotrophic lateral sclerosis (ALS typically begins with localized muscle weakness. Progressive, widespread paralysis often follows over a few years. Does the disease begin with local changes in a small piece of neural tissue and then spread? Or does neural decay happen independently across diverse spatial locations? The distinction matters, because local initiation may arise by local changes in a tissue microenvironment, by somatic mutation, or by various epigenetic or regulatory fluctuations in a few cells. A local trigger must be coupled with a mechanism for spread. By contrast, independent decay across spatial locations cannot begin by a local change, but must depend on some global predisposition or spatially distributed change that leads to approximately synchronous decay. This article outlines the conceptual frame by which one contrasts local triggers and spread versus parallel spatially distributed decay. Various neurodegenerative diseases differ in their mechanistic details, but all can usefully be understood as falling along a continuum of interacting local and global processes. Cancer provides an example of disease progression by local triggers and spatial spread, setting a conceptual basis for clarifying puzzles in neurodegeneration. Heart disease also has crucial interactions between global processes, such as circulating lipid levels, and local processes in the development of atherosclerotic plaques. The distinction between local and global processes helps to understand these various age-related diseases.

  7. Geneva University - Measurement of the Lamb shift in muonic hydrogen: the proton radius puzzle

    CERN Multimedia

    2010-01-01

    GENEVA UNIVERSITY École de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENEVA 4 Tel: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 12 May 2010 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Measurement of the Lamb shift in muonic hydrogen: the proton radius puzzle Dr Aldo Antogninia , CREMA Collaboration, Max Planck Institute, Germany At the Paul Scherrer Institut, Switzerland, we have measured several 2S-2P transition frequencies in muonic hydrogen (µp) and deuterium (µd) by means of laser spectroscopy. This results in an order of magnitude improvement on the rms charge radius values of the proton and the deuteron. Additionally the Zemach radii and the deuteron polarizability are also inferred. The new proton radius value is deduced with a relative accuracy of 0.1% but strongly disagrees from CODATA. The origin of this discrepancy is not yet known. It may come from theo...

  8. Learning and Memory Processes Following Cochlear Implantation: The Missing Piece of the Puzzle

    Science.gov (United States)

    Pisoni, David B.; Kronenberger, William G.; Chandramouli, Suyog H.; Conway, Christopher M.

    2016-01-01

    At the present time, there is no question that cochlear implants (CIs) work and often work very well in quiet listening conditions for many profoundly deaf children and adults. The speech and language outcomes data published over the last two decades document quite extensively the clinically significant benefits of CIs. Although there now is a large body of evidence supporting the “efficacy” of CIs as a medical intervention for profound hearing loss in both children and adults, there still remain a number of challenging unresolved clinical and theoretical issues that deal with the “effectiveness” of CIs in individual patients that have not yet been successfully resolved. In this paper, we review recent findings on learning and memory, two central topics in the field of cognition that have been seriously neglected in research on CIs. Our research findings on sequence learning, memory and organization processes, and retrieval strategies used in verbal learning and memory of categorized word lists suggests that basic domain-general learning abilities may be the missing piece of the puzzle in terms of understanding the cognitive factors that underlie the enormous individual differences and variability routinely observed in speech and language outcomes following cochlear implantation. PMID:27092098

  9. Puzzle of the 6Li Quadrupole Moment: Steps toward Solving It

    International Nuclear Information System (INIS)

    Blokhintsev, L.D.; Kukulin, V.I.; Pomerantsev, V.N.

    2005-01-01

    The problem of the origin of the quadrupole deformation in the 6 Li ground state is investigated with allowance for the three-deuteron component of the 6 Li wave function. Two long-standing puzzles related to the tensor interaction in the 6 Li nucleus are known: that of an anomalous smallness of the 6 Li quadrupole moment (being negative, it is smaller in magnitude than the 7 Li quadrupole moment by a factor of 5) and that of an anomalous behavior of the tensor analyzing power T 2q in the scattering of polarized 6 Li nuclei on various targets. It is shown that a large (in magnitude) negative exchange contribution to the 6 Li quadrupole moment from the three-deuteron configuration cancels almost completely the 'direct' positive contribution due to the αd folding potential. As a result, the total quadrupole moment proves to be close to zero and highly sensitive to fine details of the tensor nucleon-nucleon interaction in the 4 He nucleus and of its wave function

  10. Physics and financial economics (1776-2014): puzzles, Ising and agent-based models.

    Science.gov (United States)

    Sornette, Didier

    2014-06-01

    This short review presents a selected history of the mutual fertilization between physics and economics--from Isaac Newton and Adam Smith to the present. The fundamentally different perspectives embraced in theories developed in financial economics compared with physics are dissected with the examples of the volatility smile and of the excess volatility puzzle. The role of the Ising model of phase transitions to model social and financial systems is reviewed, with the concepts of random utilities and the logit model as the analog of the Boltzmann factor in statistical physics. Recent extensions in terms of quantum decision theory are also covered. A wealth of models are discussed briefly that build on the Ising model and generalize it to account for the many stylized facts of financial markets. A summary of the relevance of the Ising model and its extensions is provided to account for financial bubbles and crashes. The review would be incomplete if it did not cover the dynamical field of agent-based models (ABMs), also known as computational economic models, of which the Ising-type models are just special ABM implementations. We formulate the 'Emerging Intelligence Market Hypothesis' to reconcile the pervasive presence of 'noise traders' with the near efficiency of financial markets. Finally, we note that evolutionary biology, more than physics, is now playing a growing role to inspire models of financial markets.

  11. Gravity does not exist a puzzle for the 21st century

    CERN Document Server

    Icke, Vincent

    2014-01-01

    Every scientific fact begins as an opinion about the unknown—a theory—that becomes fact as evidence piles up to support it. But what if two theories exist that correspond perfectly to observed phenomena and they cannot be reconciled with each other? Can theory become fact? Such is the dilemma in contemporary physics. In seeking to understand the mechanisms of the universe, physicists have arrived at two conflicting theories: one explains the mystery of gravity through a precise model of space and time, and the other explains the mystery of matter via the behavior of quantum particles. Each theory reigns in its own domain. But 13.8 billion years ago, when the universe first came into being, gravity and matter belonged to a single realm. Can these theories be united, and if so, what facts will be revealed? This, contends Vincent Icke, is the central puzzle facing physics in our century. Combining Icke’s expertise with a robust argument and intellectual playfulness, Gravity Does Not Exist makes a notorious...

  12. Low-voltage puzzle-like fractal microelectromechanial system variable capacitor suppressing pull-in

    KAUST Repository

    Elshurafa, Amro M.; Ho, P.H.; Ouda, Mahmoud H.; Radwan, Ahmed Gomaa; Salama, Khaled N.

    2012-01-01

    This Letter introduces an electrostatically actuated fractal MEMS variable capacitor that, by utilising the substrate, extends the tuning range (TR) beyond the theoretical limit of 1.5 as dictated by the pull-in phenomenon. The backbone concept behind the fractal varactor is to create a suspended movable plate possessing a specific fractal geometry, and to simultaneously create a bottom fixed plate complementary in shape to the top plate. Thus, when the top plate is actuated, it moves towards the bottom plate and fills the void present within the bottom plate without touching it akin to how puzzle pieces are assembled. Further, a reasonable horizontal separation is maintained between both the plates to avoid shorting. The electrostatic forces come from the capacitance formed between the top plate and bottom plate, and from the capacitance formed between the top plate and the doped substrate. The variable capacitor was fabricated in the PolyMUMPS process and provided a TR of 4.1 at 6 V, and its resonant frequency was in excess of 40 GHz.

  13. The π+-emission puzzle in 4 over Lambda He decay

    International Nuclear Information System (INIS)

    Gibson, B.F.; Timmermans, R.

    1997-10-01

    The observed π + emission from the weak decay of 4 over Λ He has long been an intriguing puzzle. Experimentally, the π + to π - ratio for 4 over Λ He decay is about 5%. Because mesonic decay modes of the free Λ (→ p + π - , n + π 0 ) produce no π + s, more complicated mechanisms must be responsible for the π + decay of 4 over Λ He. Dalitz and von Hippel explored two-body decay processes of the type: (1) Λ → π 0 + n decay followed by a π 0 + p → π + + n charge-exchange reaction, and (2) Σ + → π + + n decay following a Λ + p → Σ + + n conversion. They concluded that neither process could account for even a 1% π + + n decay as a p-wave process ruled out the promising explanation coming from von Hippel's calculations, which had found that s-wave Σ + decay might yield a sufficiently high rate. Cieply and Gal re-examined the charge-exchange contribution and concluded that, although up-to-date input parameters yield a 1.2% branching ratio, the charge-exchange mechanism cannot account for the experimental value of about 5%

  14. Natural killer cells: the journey from puzzles in biology to treatment of cancer.

    Science.gov (United States)

    Bodduluru, Lakshmi Narendra; Kasala, Eshvendar Reddy; Madhana, Rajaram Mohan Rao; Sriram, Chandra Shaker

    2015-02-28

    Natural Killer (NK) cells are innate immune effectors that are primarily involved in immunosurveillance to spontaneously eliminate malignantly transformed and virally infected cells without prior sensitization. NK cells trigger targeted attack through release of cytotoxic granules, and secrete various cytokines and chemokines to promote subsequent adaptive immune responses. NK cells selectively attack target cells with diminished major histocompatibility complex (MHC) class I expression. This "Missing-self" recognition by NK cells at first puzzled researchers in the early 1990s, and the mystery was solved with the discovery of germ line encoded killer immunoglobulin receptors that recognize MHC-I molecules. This review summarizes the biology of NK cells detailing the phenotypes, receptors and functions; interactions of NK cells with dendritic cells (DCs), macrophages and T cells. Further we discuss the various strategies to modulate NK cell activity and the practice of NK cells in cancer immunotherapy employing NK cell lines, autologous, allogeneic and genetically engineered cell populations. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  15. Barriers to Implementation of Primary Percutaneous Coronary Intervention in Europe

    DEFF Research Database (Denmark)

    Laut, Kristina Grønborg; Pedersen, Alma Becic; Lash, Timothy

    2011-01-01

    Primary percutaneous coronary intervention (PPCI) is the recommended treatment for patients with acute ST-segment elevation myocardial infarction (STEMI). Despite substantial evidence of its effectiveness, only 40–45% of European STEMI patients are currently treated with PPCI and there are large ...... is needed. Keywords Primary percutaneous coronary intervention, acute ST-elevation myocardial infarction, implementation, practice variation, registry data......Primary percutaneous coronary intervention (PPCI) is the recommended treatment for patients with acute ST-segment elevation myocardial infarction (STEMI). Despite substantial evidence of its effectiveness, only 40–45% of European STEMI patients are currently treated with PPCI and there are large...... the diffusion of PPCI in Europe. The lack of complete implementation and large national and regional differences arise from the interplay between technology, patients, policy makers, culture and resources. Explanations for the variation in treatment access still remain a puzzle and access to valid data...

  16. Primary productivity

    Digital Repository Service at National Institute of Oceanography (India)

    Verlecar, X.N.; Parulekar, A.H.

    Photosynthetic production in the oceans in relation to light, nutrients and mixing processes is discussed. Primary productivity in the estuarine region is reported to be high in comparison to coastal and oceanic waters. Upwelling phenomenon...

  17. Primary Hyperparathyroidism

    Science.gov (United States)

    ... Neoplasia Type 1 Thyroid Disease & Pregnancy Primary Hyperparathyroidism Prolactinoma National Hormone and Pituitary Program (NHPP): Information for ... qualified health care provider nearby. Eating, Diet, and Nutrition Eating, diet, and nutrition have not been shown ...

  18. Primary Myelofibrosis

    Science.gov (United States)

    ... attack is higher. Patients also have an increased risk of acute myeloid leukemia or primary myelofibrosis . Symptoms of polycythemia vera include headaches and a feeling of fullness below the ribs on the left ...

  19. Animal egg as evolutionary innovation: a solution to the "embryonic hourglass" puzzle.

    Science.gov (United States)

    Newman, Stuart A

    2011-11-15

    mechanisms operate. Finally, I describe how this new perspective provides a resolution to the embryonic hourglass puzzle. Copyright © 2011 Wiley Periodicals, Inc.

  20. Neural bases for basic processes in heuristic problem solving: Take solving Sudoku puzzles as an example.

    Science.gov (United States)

    Qin, Yulin; Xiang, Jie; Wang, Rifeng; Zhou, Haiyan; Li, Kuncheng; Zhong, Ning

    2012-12-01

    Newell and Simon postulated that the basic steps in human problem-solving involve iteratively applying operators to transform the state of the problem to eventually achieve a goal. To check the neural basis of this framework, the present study focused on the basic processes in human heuristic problem-solving that the participants identified the current problem state and then recalled and applied the corresponding heuristic rules to change the problem state. A new paradigm, solving simplified Sudoku puzzles, was developed for an event-related functional magnetic resonance imaging (fMRI) study in problem solving. Regions of interest (ROIs), including the left prefrontal cortex, the bilateral posterior parietal cortex, the anterior cingulated cortex, the bilateral caudate nuclei, the bilateral fusiform, as well as the bilateral frontal eye fields, were found to be involved in the task. To obtain convergent evidence, in addition to traditional statistical analysis, we used the multivariate voxel classification method to check the accuracy of the predictions for the condition of the task from the blood oxygen level dependent (BOLD) response of the ROIs, using a new classifier developed in this study for fMRI data. To reveal the roles that the ROIs play in problem solving, we developed an ACT-R computational model of the information-processing processes in human problem solving, and tried to predict the BOLD response of the ROIs from the task. Advances in human problem-solving research after Newell and Simon are then briefly discussed. © 2012 The Institute of Psychology, Chinese Academy of Sciences and Blackwell Publishing Asia Pty Ltd.

  1. Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle.

    Science.gov (United States)

    Rech, Monika; Barandiarán Aizpurua, Arantxa; van Empel, Vanessa; van Bilsen, Marc; Schroen, Blanche

    2018-05-01

    Half of all heart failure patients have preserved ejection fraction (HFpEF). Comorbidities associated with and contributing to HFpEF include obesity, diabetes and hypertension. Still, the underlying pathophysiological mechanisms of HFpEF are unknown. A preliminary consensus proposes that the multi-morbidity triggers a state of systemic, chronic low-grade inflammation, and microvascular dysfunction, causing reduced nitric oxide bioavailability to adjacent cardiomyocytes. As a result, the cardiomyocyte remodels its contractile elements and fails to relax properly, causing diastolic dysfunction, and eventually HFpEF. HFpEF is a complex syndrome for which currently no efficient therapies exist. This is notably due to the current one-size-fits-all therapy approach that ignores individual patient differences. MicroRNAs have been studied in relation to pathophysiological mechanisms and comorbidities underlying and contributing to HFpEF. As regulators of gene expression, microRNAs may contribute to the pathophysiology of HFpEF. In addition, secreted circulating microRNAs are potential biomarkers and as such, they could help stratify the HFpEF population and open new ways for individualized therapies. In this review, we provide an overview of the ever-expanding world of non-coding RNAs and their contribution to the molecular mechanisms underlying HFpEF. We propose prospects for microRNAs in stratifying the HFpEF population. MicroRNAs add a new level of complexity to the regulatory network controlling cardiac function and hence the understanding of gene regulation becomes a fundamental piece in solving the HFpEF puzzle.

  2. Lifetime of (e+e-) puzzle's composite particle: No valid limits yet

    International Nuclear Information System (INIS)

    Griffin, J.J.

    1993-01-01

    Several recent articles assert that the increasingly precise null results of Bhabha scattering imply ''model-independent'' increasing lower bounds upon the lifetime of any neutral particle whose decay is hypothesized to yield the sharp lines of the GSI ''(e + e-) puzzle.'' We discuss here reasons why such conclusions must be considered as artifacts of the assumptions made in the analysis, and not as valid scientific deductions from the data alone. Furthermore, we show that when such data are combined with additional assumptions sufficient to allow an inference about the lifetime, then the conclusion is inevitably dependent explicitly or implicitly upon the model assumed for the particle decay. In addition, we discuss why the limits asserted upon the lifetime of such a particle from the high precision agreement for g e -2 between experiment and theoretical quantum electrodynamics apply only to an elementary particle, but not to a composite particle, and especially not to a leptonic composite. In the end, no valid limits upon the composite particle lifetime seems to exist at present. We also consider, in the context of the general partial width data problem, the additional experimental data which could suffice to sustain a purely empirical limit upon the lifetime, and observe that all of the present data are consistent with a composite particle with a significant amplitude in the four lepton (e + e+e-e-) ''quadronium'' sector. Finally, it is shown that recent preliminary Bhabha inelastic (e + e+γ) data, if confirmed, would imply the crude but genuinely empirical upper bound upon the resonance lifetime of about τ max ∼2x10 -11 sec≥τ

  3. A dialog with a puzzled profile: Poetry of an old pedological discussion

    Science.gov (United States)

    Itkin, Danny

    2017-04-01

    Defining and classifying are fundamental needs in the everyday life of humans. Among quite a few relevant examples in pedology, stands the question of whether soils and some types of sediments should or can be distinct. This issue is as old as soil science itself and is possibly very much related to the never ending debate regarding "the definition of soil". As is the case in many fields, the necessity of humans to create and keep a uniform common language might collide with different cultural and/or scientific perspectives. Such is the case with the wide variety of soil classifications found throughout the world. One can easily note this diversity when reading publications that address two similar regolith profiles from different locations round the globe. In some cases it would be impossible to correlate two comparable profiles when using different classification systems. This contradictory situation is one of the most challenging topics in pedology. This whole background gave the inspiration for the following poem, titled "A dialog with a puzzled profile": Are you a soil or a sediment? Ask the oak, see if he knows. Ask him whether these are peds Or maybe a bedrock under his toes. And if you're a soil, what are you? It depends on the viewpoint, you see: Some define me with Soil Taxonomy, While others with WRB. For Hutton and Lyell I'm a weathered rock, Yet Hilgard and Dokuchaev dispute. If you ask me, well I'm a 'pedosediment', I couldn't care less for the suit. If it helps you I'll be whatever it takes,
Making sure that no one will lose. I know it depends very much on the platform Where experts are setting the rules.

  4. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

    Science.gov (United States)

    Lee, S Hong; Byrne, Enda M; Hultman, Christina M; Kähler, Anna; Vinkhuyzen, Anna A E; Ripke, Stephan; Andreassen, Ole A; Frisell, Thomas; Gusev, Alexander; Hu, Xinli; Karlsson, Robert; Mantzioris, Vasilis X; McGrath, John J; Mehta, Divya; Stahl, Eli A; Zhao, Qiongyi; Kendler, Kenneth S; Sullivan, Patrick F; Price, Alkes L; O'Donovan, Michael; Okada, Yukinori; Mowry, Bryan J; Raychaudhuri, Soumya; Wray, Naomi R; Byerley, William; Cahn, Wiepke; Cantor, Rita M; Cichon, Sven; Cormican, Paul; Curtis, David; Djurovic, Srdjan; Escott-Price, Valentina; Gejman, Pablo V; Georgieva, Lyudmila; Giegling, Ina; Hansen, Thomas F; Ingason, Andrés; Kim, Yunjung; Konte, Bettina; Lee, Phil H; McIntosh, Andrew; McQuillin, Andrew; Morris, Derek W; Nöthen, Markus M; O'Dushlaine, Colm; Olincy, Ann; Olsen, Line; Pato, Carlos N; Pato, Michele T; Pickard, Benjamin S; Posthuma, Danielle; Rasmussen, Henrik B; Rietschel, Marcella; Rujescu, Dan; Schulze, Thomas G; Silverman, Jeremy M; Thirumalai, Srinivasa; Werge, Thomas; Agartz, Ingrid; Amin, Farooq; Azevedo, Maria H; Bass, Nicholas; Black, Donald W; Blackwood, Douglas H R; Bruggeman, Richard; Buccola, Nancy G; Choudhury, Khalid; Cloninger, Robert C; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J; Datta, Susmita; Donohoe, Gary J; Duan, Jubao; Dudbridge, Frank; Fanous, Ayman; Freedman, Robert; Freimer, Nelson B; Friedl, Marion; Gill, Michael; Gurling, Hugh; De Haan, Lieuwe; Hamshere, Marian L; Hartmann, Annette M; Holmans, Peter A; Kahn, René S; Keller, Matthew C; Kenny, Elaine; Kirov, George K; Krabbendam, Lydia; Krasucki, Robert; Lawrence, Jacob; Lencz, Todd; Levinson, Douglas F; Lieberman, Jeffrey A; Lin, Dan-Yu; Linszen, Don H; Magnusson, Patrik K E; Maier, Wolfgang; Malhotra, Anil K; Mattheisen, Manuel; Mattingsdal, Morten; McCarroll, Steven A; Medeiros, Helena; Melle, Ingrid; Milanova, Vihra; Myin-Germeys, Inez; Neale, Benjamin M; Ophoff, Roel A; Owen, Michael J; Pimm, Jonathan; Purcell, Shaun M; Puri, Vinay; Quested, Digby J; Rossin, Lizzy; Ruderfer, Douglas; Sanders, Alan R; Shi, Jianxin; Sklar, Pamela; St Clair, David; Stroup, T Scott; Van Os, Jim; Visscher, Peter M; Wiersma, Durk; Zammit, Stanley; Bridges, S Louis; Choi, Hyon K; Coenen, Marieke J H; de Vries, Niek; Dieud, Philippe; Greenberg, Jeffrey D; Huizinga, Tom W J; Padyukov, Leonid; Siminovitch, Katherine A; Tak, Paul P; Worthington, Jane; De Jager, Philip L; Denny, Joshua C; Gregersen, Peter K; Klareskog, Lars; Mariette, Xavier; Plenge, Robert M; van Laar, Mart; van Riel, Piet

    2015-10-01

    A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship between two uncommon disorders. We use genome-wide common single nucleotide polymorphism (SNP) data from independently collected SZ and RA case-control cohorts to estimate the SNP correlation between the disorders. We test a genotype X environment (GxE) hypothesis for SZ with environment defined as winter- vs summer-born. We estimate a small but significant negative SNP-genetic correlation between SZ and RA (-0.046, s.e. 0.026, P = 0.036). The negative correlation was stronger for the SNP set attributed to coding or regulatory regions (-0.174, s.e. 0.071, P = 0.0075). Our analyses led us to hypothesize a gene-environment interaction for SZ in the form of immune challenge. We used month of birth as a proxy for environmental immune challenge and estimated the genetic correlation between winter-born and non-winter born SZ to be significantly less than 1 for coding/regulatory region SNPs (0.56, s.e. 0.14, P = 0.00090). Our results are consistent with epidemiological observations of a negative relationship between SZ and RA reflecting, at least in part, genetic factors. Results of the month of birth analysis are consistent with pleiotropic effects of genetic variants dependent on environmental context.

  5. The puzzle of the ankle in the Ultrahigh Energy Cosmic Ray Spectrum, and composition indicators

    Science.gov (United States)

    Farrar, Glennys

    2015-08-01

    The sharp change in slope of the ultra-high energy cosmic ray spectrum around 10^18.6 eV (the ankle), combined with evidence of a light but extragalactic component near and below the ankle and intermediate composition above, has proved exceedingly challenging to understand theoretically. In this talk I discuss two possible solutions to the puzzle and how they can be (in)validated.First, I present a new mechanism whereby photo-disintegration of ultra-high energy nuclei in the region surrounding a UHECR accelerator naturally accounts for the observed spectrum and inferred composition (using LHC-tuned models extrapolated to UHE) at Earth. We discuss the conditions required to reproduce the spectrum above 10^17.5 eV and the composition, which -- in our model -- consists below the ankle of extragalactic protons and the high energy tail of Galactic Cosmic Rays, and above the ankle of surviving nuclei from the extended source. Predictions for the spectrum and flavors of neutrinos resulting from this process will be presented, and also implications for candidate sources.The other possible explanation is that in actuality UHECRs are entirely or almost entirely protons, and the cross-section for p-Air scattering increases more rapidly above center-of-mass energy of 70 TeV (10 times the current LHC cm energy) than predicted in conventional models. This gives an equally good fit to the depth-of-shower maximum behavior obverved by Auger, while being an intriguing sign of new state in QCD at extremely high energy density.

  6. Root sprouting in Knautia arvensis (Dipsacaceae): effects of polyploidy, soil origin and nutrient availability

    Czech Academy of Sciences Publication Activity Database

    Martínková, Jana; Klimešová, Jitka; Doležal, Jiří; Kolář, Filip

    2015-01-01

    Roč. 216, č. 6 (2015), s. 901-911 ISSN 1385-0237 R&D Projects: GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : root-sprouting * ploidy * Knautia arvensis Subject RIV: EF - Botanics Impact factor: 1.490, year: 2015

  7. Larvicidal efficacy of Scabiosa arenaria Forssk. (Dipsacaceae organs extracts against Culex pipiens L.

    Directory of Open Access Journals (Sweden)

    Malek Besbes Hlila

    2017-11-01

    Full Text Available Objective: To determine the larvicidal activity of sixteen extracts of Scabiosa arenaria Forssk. (S. arenaria against the third instar larvae of Culex pipiens L. (C. pipiens. Methods: Larvicidal activity of S. arenaria extracts was determined according to World Health Organization. Twenty third instars of the C. pipiens were exposed to different concentrations (15 µg/mL to 60 µg/mL of extracts. Mortality was recorded after 24 h of exposure. Results: The roots ethyl acetate fraction of S. arenaria had a significant toxic effect on larvae of C. pipiens, with high mortality percentage (100.0% ± 2.2% at 60 µg/mL, and 50% lethal concentration value of LC50 = (15.00 ± 0.09 µg/mL. Conclusions: Results show that roots ethyl acetate could be used for the production of natural bio-pesticides which could decrease our dependence on chemical pesticides.

  8. Piecing together the puzzle: Improving event content coverage for real-time sub-event detection using adaptive microblog crawling.

    Directory of Open Access Journals (Sweden)

    Laurissa Tokarchuk

    Full Text Available In an age when people are predisposed to report real-world events through their social media accounts, many researchers value the benefits of mining user generated content from social media. Compared with the traditional news media, social media services, such as Twitter, can provide more complete and timely information about the real-world events. However events are often like a puzzle and in order to solve the puzzle/understand the event, we must identify all the sub-events or pieces. Existing Twitter event monitoring systems for sub-event detection and summarization currently typically analyse events based on partial data as conventional data collection methodologies are unable to collect comprehensive event data. This results in existing systems often being unable to report sub-events in real-time and often in completely missing sub-events or pieces in the broader event puzzle. This paper proposes a Sub-event detection by real-TIme Microblog monitoring (STRIM framework that leverages the temporal feature of an expanded set of news-worthy event content. In order to more comprehensively and accurately identify sub-events this framework first proposes the use of adaptive microblog crawling. Our adaptive microblog crawler is capable of increasing the coverage of events while minimizing the amount of non-relevant content. We then propose a stream division methodology that can be accomplished in real time so that the temporal features of the expanded event streams can be analysed by a burst detection algorithm. In the final steps of the framework, the content features are extracted from each divided stream and recombined to provide a final summarization of the sub-events. The proposed framework is evaluated against traditional event detection using event recall and event precision metrics. Results show that improving the quality and coverage of event contents contribute to better event detection by identifying additional valid sub-events. The

  9. New Measurement of the 1 S -3 S Transition Frequency of Hydrogen: Contribution to the Proton Charge Radius Puzzle

    Science.gov (United States)

    Fleurbaey, Hélène; Galtier, Sandrine; Thomas, Simon; Bonnaud, Marie; Julien, Lucile; Biraben, François; Nez, François; Abgrall, Michel; Guéna, Jocelyne

    2018-05-01

    We present a new measurement of the 1 S -3 S two-photon transition frequency of hydrogen, realized with a continuous-wave excitation laser at 205 nm on a room-temperature atomic beam, with a relative uncertainty of 9 ×10-13. The proton charge radius deduced from this measurement, rp=0.877 (13 ) fm , is in very good agreement with the current CODATA-recommended value. This result contributes to the ongoing search to solve the proton charge radius puzzle, which arose from a discrepancy between the CODATA value and a more precise determination of rp from muonic hydrogen spectroscopy.

  10. Definition of a visuospatial dimension as a step forward in the diagnostic puzzle of nonverbal learning disability.

    Science.gov (United States)

    Poletti, Michele

    2017-01-01

    Although clinically recognized for almost 50 years, the categorical distinction of specific learning disabilities due to an impairment of the nonverbal domain (nonverbal learning disability [NLD]) is still debated and controversial. Unsolved issues involve theoretical models, diagnostic criteria, rehabilitative interventions, and moderator factors. These issues are briefly overviewed to sustain the need for a shift toward dimensional approaches, as suggested by research domain criteria, as a step forward in the diagnostic puzzle of NLD. With this aim, a visuospatial dimension, or spectrum, is proposed, and then clinical conditions that may fit with its impaired side are systemized, while specifying in which conditions a visuospatial impairment may be considered an NLD.

  11. Piecing together the puzzle: Improving event content coverage for real-time sub-event detection using adaptive microblog crawling.

    Science.gov (United States)

    Tokarchuk, Laurissa; Wang, Xinyue; Poslad, Stefan

    2017-01-01

    In an age when people are predisposed to report real-world events through their social media accounts, many researchers value the benefits of mining user generated content from social media. Compared with the traditional news media, social media services, such as Twitter, can provide more complete and timely information about the real-world events. However events are often like a puzzle and in order to solve the puzzle/understand the event, we must identify all the sub-events or pieces. Existing Twitter event monitoring systems for sub-event detection and summarization currently typically analyse events based on partial data as conventional data collection methodologies are unable to collect comprehensive event data. This results in existing systems often being unable to report sub-events in real-time and often in completely missing sub-events or pieces in the broader event puzzle. This paper proposes a Sub-event detection by real-TIme Microblog monitoring (STRIM) framework that leverages the temporal feature of an expanded set of news-worthy event content. In order to more comprehensively and accurately identify sub-events this framework first proposes the use of adaptive microblog crawling. Our adaptive microblog crawler is capable of increasing the coverage of events while minimizing the amount of non-relevant content. We then propose a stream division methodology that can be accomplished in real time so that the temporal features of the expanded event streams can be analysed by a burst detection algorithm. In the final steps of the framework, the content features are extracted from each divided stream and recombined to provide a final summarization of the sub-events. The proposed framework is evaluated against traditional event detection using event recall and event precision metrics. Results show that improving the quality and coverage of event contents contribute to better event detection by identifying additional valid sub-events. The novel combination of

  12. On the reversibility of the Meissner effect and the angular momentum puzzle

    International Nuclear Information System (INIS)

    Hirsch, J.E.

    2016-01-01

    suppress Foucault currents, charge has to flow in direction perpendicular to the phase boundary. • The charge carriers have to be holes. • This solves also the angular momentum puzzle associated with the Meissner effect.

  13. There and back again: Two views on the protein folding puzzle.

    Science.gov (United States)

    Finkelstein, Alexei V; Badretdin, Azat J; Galzitskaya, Oxana V; Ivankov, Dmitry N; Bogatyreva, Natalya S; Garbuzynskiy, Sergiy O

    2017-07-01

    The ability of protein chains to spontaneously form their spatial structures is a long-standing puzzle in molecular biology. Experimentally measured folding times of single-domain globular proteins range from microseconds to hours: the difference (10-11 orders of magnitude) is the same as that between the life span of a mosquito and the age of the universe. This review describes physical theories of rates of overcoming the free-energy barrier separating the natively folded (N) and unfolded (U) states of protein chains in both directions: "U-to-N" and "N-to-U". In the theory of protein folding rates a special role is played by the point of thermodynamic (and kinetic) equilibrium between the native and unfolded state of the chain; here, the theory obtains the simplest form. Paradoxically, a theoretical estimate of the folding time is easier to get from consideration of protein unfolding (the "N-to-U" transition) rather than folding, because it is easier to outline a good unfolding pathway of any structure than a good folding pathway that leads to the stable fold, which is yet unknown to the folding protein chain. And since the rates of direct and reverse reactions are equal at the equilibrium point (as follows from the physical "detailed balance" principle), the estimated folding time can be derived from the estimated unfolding time. Theoretical analysis of the "N-to-U" transition outlines the range of protein folding rates in a good agreement with experiment. Theoretical analysis of folding (the "U-to-N" transition), performed at the level of formation and assembly of protein secondary structures, outlines the upper limit of protein folding times (i.e., of the time of search for the most stable fold). Both theories come to essentially the same results; this is not a surprise, because they describe overcoming one and the same free-energy barrier, although the way to the top of this barrier from the side of the unfolded state is very different from the way from the

  14. On the reversibility of the Meissner effect and the angular momentum puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Hirsch, J.E., E-mail: jhirsch@ucsd.edu

    2016-10-15

    suppress Foucault currents, charge has to flow in direction perpendicular to the phase boundary. • The charge carriers have to be holes. • This solves also the angular momentum puzzle associated with the Meissner effect.

  15. Juggling the life-puzzle with Geosciences: personal experience and strategies from a female leader

    Science.gov (United States)

    Arheimer, Berit

    2017-04-01

    recommendations from being a single-mother with scientific and international ambitions, working in an operational environment, on how to juggle the dynamic life puzzle.

  16. William Wales and the 1769 transit of Venus: puzzle solving and the determination of the astronomical unit

    Science.gov (United States)

    Metz, Don

    2009-05-01

    According to Thomas Kuhn, a significant part of “normal science” is the fact gathering, empirical work which is intended to illustrate an existing paradigm. Some of this effort focuses on the determination of physical constants such as the astronomical unit (AU). For Kuhn, normal science is also what prepares students for membership in a particular scientific community and is embodied in some form in our science textbooks. However, neither Kuhn nor the textbook says much about the individuals who practice normal science, especially those who had been relegated to the “hack” duties of long and arduous measurement and calculation. In this paper, to provide a context for students of astronomy, I will outline the story of the determination of the AU and in particular the contribution of William Wales, an obscure British astronomer. Wales, toiling in the shadow of Halley (of Halley’s comet fame), Mason and Dixon (of Mason and Dixon line fame) and the infamous Captain Cook endured a brutal winter in northern Canada for a brief glimpse of the 1769 transit of Venus. In the end, Wales supplied one small piece of the puzzle in the determination of the AU and he exemplified the human spirit and persistence of a Kuhnian “puzzle solver”.

  17. DNA is structured as a linear "jigsaw puzzle" in the genomes of Arabidopsis, rice, and budding yeast.

    Science.gov (United States)

    Liu, Yun-Hua; Zhang, Meiping; Wu, Chengcang; Huang, James J; Zhang, Hong-Bin

    2014-01-01

    Knowledge of how a genome is structured and organized from its constituent elements is crucial to understanding its biology and evolution. Here, we report the genome structuring and organization pattern as revealed by systems analysis of the sequences of three model species, Arabidopsis, rice and yeast, at the whole-genome and chromosome levels. We found that all fundamental function elements (FFE) constituting the genomes, including genes (GEN), DNA transposable elements (DTE), retrotransposable elements (RTE), simple sequence repeats (SSR), and (or) low complexity repeats (LCR), are structured in a nonrandom and correlative manner, thus leading to a hypothesis that the DNA of the species is structured as a linear "jigsaw puzzle". Furthermore, we showed that different FFE differ in their importance in the formation and evolution of the DNA jigsaw puzzle structure between species. DTE and RTE play more important roles than GEN, LCR, and SSR in Arabidopsis, whereas GEN and RTE play more important roles than LCR, SSR, and DTE in rice. The genes having multiple recognized functions play more important roles than those having single functions. These results provide useful knowledge necessary for better understanding genome biology and evolution of the species and for effective molecular breeding of rice.

  18. Can the consumption-free nonexpected utility model solve the risk premium puzzle? An empirical study of the Japanese stock market

    OpenAIRE

    Kang, Myong-Il

    2010-01-01

    This paper investigates whether the consumption-free two-beta intertemporal capital asset-pricing model developed by Campbell and Vuolteenaho (2004) is able to solve the risk premium puzzle in the Japanese stock market over the period 1984-2002. Using the cash flow and discount rate betas as risk factors, the model is able to explain about half of the market returns by selection of suitable vector autoregression variables. On this basis, the model proposed solves the risk premium puzzle in Ja...

  19. [Hypertension: once primary, always primary?

    NARCIS (Netherlands)

    Braam, R.L.; Pieters, G.F.F.M.; Thien, Th.

    2002-01-01

    Three patients diagnosed with primary hypertension suddenly developed hard-to-treat blood pressure after several years of stable blood pressure. One patient, a man aged 48 years, had developed a renal artery stenosis, which had not been present five years earlier. The other two patients, a man aged

  20. Hyperthyroidism (primary)

    OpenAIRE

    Nygaard, Birte

    2010-01-01

    Hyperthyroidism is characterised by high levels of serum thyroxine and triiodothyronine, and low levels of thyroid-stimulating hormone (TSH). Thyrotoxicosis is the clinical effect of high levels of thyroid hormones, whether or not the thyroid gland is the primary source.The main causes of hyperthyroidism are Graves' disease, toxic multinodular goitre, and toxic adenoma.About 20 times more women than men have hyperthyroidism.

  1. The concepts of asymmetric and symmetric power can help resolve the puzzle of altruistic and cooperative behaviour.

    Science.gov (United States)

    Phillips, Tim

    2018-02-01

    Evolutionary theory predicts competition in nature yet altruistic and cooperative behaviour appears to reduce the ability to compete in order to help others compete better. This evolutionary puzzle is usually explained by kin selection where close relatives perform altruistic and cooperative acts to help each other and by reciprocity theory (i.e. direct, indirect and generalized reciprocity) among non-kin. Here, it is proposed that the concepts of asymmetry and symmetry in power and dominance are critical if we are ever to resolve the puzzle of altruism and cooperation towards non-kin. Asymmetry in power and dominance is likely to emerge under competition in nature as individuals strive to gain greater access to the scarce resources needed to survive and reproduce successfully. Yet asymmetric power presents serious problems for reciprocity theory in that a dominant individual faces a temptation to cheat in interactions with subordinates that is likely to far outweigh any individual selective benefits gained through reciprocal mechanisms. Furthermore, action taken by subordinates to deter non-reciprocation by dominants is likely to prove prohibitively costly to their fitness, making successful enforcement of reciprocal mechanisms unlikely. It is also argued here that many apparently puzzling forms of cooperation observed in nature (e.g. cooperative breeding in which unrelated subordinates help dominants to breed) might be best explained by asymmetry in power and dominance. Once it is recognized that individuals in these cooperative interactions are subject to the constraints and opportunities imposed on them by asymmetric power then they can be seen as pursuing a 'least bad' strategy to promote individual fitness - one that is nevertheless consistent with evolutionary theory. The concept of symmetric power also provides important insights. It can inhibit reciprocal mechanisms in the sense that symmetric power makes it easier for a cheat to appropriate common

  2. The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia.

    Science.gov (United States)

    Ben Abdallah, Nada M-B; Fuss, Johannes; Trusel, Massimo; Galsworthy, Michael J; Bobsin, Kristin; Colacicco, Giovanni; Deacon, Robert M J; Riva, Marco A; Kellendonk, Christoph; Sprengel, Rolf; Lipp, Hans-Peter; Gass, Peter

    2011-01-01

    Deficits in executive functions are key features of schizophrenia. Rodent behavioral paradigms used so far to find animal correlates of such deficits require extensive effort and time. The puzzle box is a problem-solving test in which mice are required to complete escape tasks of increasing difficulty within a limited amount of time. Previous data have indicated that it is a quick but highly reliable test of higher-order cognitive functioning. We evaluated the use of the puzzle box to explore executive functioning in five different mouse models of schizophrenia: mice with prefrontal cortex and hippocampus lesions, mice treated sub-chronically with the NMDA-receptor antagonist MK-801, mice constitutively lacking the GluA1 subunit of AMPA-receptors, and mice over-expressing dopamine D2 receptors in the striatum. All mice displayed altered executive functions in the puzzle box, although the nature and extent of the deficits varied between the different models. Deficits were strongest in hippocampus-lesioned and GluA1 knockout mice, while more subtle deficits but specific to problem solving were found in the medial prefrontal-lesioned mice, MK-801-treated mice, and in mice with striatal overexpression of D2 receptors. Data from this study demonstrate the utility of the puzzle box as an effective screening tool for executive functions in general and for schizophrenia mouse models in particular. Published by Elsevier Inc.

  3. A note on the puzzling spindown behavior of the Galactic center magnetar SGR J1745–2900

    International Nuclear Information System (INIS)

    Tong, Hao

    2015-01-01

    SGR J1745–2900 is a magnetar near the Galactic center. X-ray observations of this source found a decreasing X-ray luminosity accompanied by an enhanced spindown rate. This negative correlation between X-ray luminosity and spindown rate is hard to understand. The wind braking model of magnetars is employed to explain this puzzling spindown behavior. During the release of magnetic energy of magnetars, a system of particles may be generated. Some of these particles remain trapped in the magnetosphere and may contribute to the X-ray luminosity. The rest of the particles can flow out and take away the rotational energy of the central neutron star. A smaller polar cap angle will cause the decrease of X-ray luminosity and enhanced spindown rate of SGR J1745–2900. This magnetar is shortly expected to have a maximum spindown rate. (paper)

  4. Double-Pionic Fusion of Nuclear Systems and the ''ABC'' Effect: Approaching a Puzzle by Exclusive and Kinematically Complete Measurements

    International Nuclear Information System (INIS)

    Bashkanov, M.; Clement, H.; Doroshkevich, E.; Khakimova, O.; Kren, F.; Meier, R.; Pricking, A.; Skorodko, T.; Wagner, G. J.; Bargholtz, C.; Geren, L.; Lindberg, K.; Tegner, P.-E.; Zartova, I.; Berlowski, M.; Stepaniak, J.; Bogoslawsky, D.; Ivanov, G.; Jiganov, E.; Morosov, B.

    2009-01-01

    The ABC effect--a puzzling low-mass enhancement in the ππ invariant mass spectrum, first observed by Abashian, Booth, and Crowe--is well known from inclusive measurements of two-pion production in nuclear fusion reactions. Here we report on the first exclusive and kinematically complete measurements of the most basic double-pionic fusion reaction pn→dπ 0 π 0 at beam energies of 1.03 and 1.35 GeV. The measurements, which have been carried out at CELSIUS-WASA, reveal the ABC effect to be a (ππ) I=L=0 channel phenomenon associated with both a resonancelike energy dependence in the integral cross section and the formation of a ΔΔ system in the intermediate state. A corresponding simple s-channel resonance ansatz provides a surprisingly good description of the data

  5. Puzzle-based versus traditional lecture: comparing the effects of pedagogy on academic performance in an undergraduate human anatomy and physiology II lab.

    Science.gov (United States)

    Stetzik, Lucas; Deeter, Anthony; Parker, Jamie; Yukech, Christine

    2015-06-23

    A traditional lecture-based pedagogy conveys information and content while lacking sufficient development of critical thinking skills and problem solving. A puzzle-based pedagogy creates a broader contextual framework, and fosters critical thinking as well as logical reasoning skills that can then be used to improve a student's performance on content specific assessments. This paper describes a pedagogical comparison of traditional lecture-based teaching and puzzle-based teaching in a Human Anatomy and Physiology II Lab. Using a single subject/cross-over design half of the students from seven sections of the course were taught using one type of pedagogy for the first half of the semester, and then taught with a different pedagogy for the second half of the semester. The other half of the students were taught the same material but with the order of the pedagogies reversed. Students' performance on quizzes and exams specific to the course, and in-class assignments specific to this study were assessed for: learning outcomes (the ability to form the correct conclusion or recall specific information), and authentic academic performance as described by (Am J Educ 104:280-312, 1996). Our findings suggest a significant improvement in students' performance on standard course specific assessments using a puzzle-based pedagogy versus a traditional lecture-based teaching style. Quiz and test scores for students improved by 2.1 and 0.4% respectively in the puzzle-based pedagogy, versus the traditional lecture-based teaching. Additionally, the assessments of authentic academic performance may only effectively measure a broader conceptual understanding in a limited set of contexts, and not in the context of a Human Anatomy and Physiology II Lab. In conclusion, a puzzle-based pedagogy, when compared to traditional lecture-based teaching, can effectively enhance the performance of students on standard course specific assessments, even when the assessments only test a limited

  6. The role of helioseismology in the knowledge of the solar interior dynamics and in the solar neutrino puzzle

    International Nuclear Information System (INIS)

    Couvidat, Sebastien

    2002-01-01

    This dissertation focuses on the solar interior dynamics and the neutrino puzzle, using helioseismology and more specifically the SoHO/GOLF data as a tool to probe the radiative interior of the Sun. We show how helioseismology gives us a direct access to the deep-layer dynamics through the solar rotation profile. Our data favor a decrease of the rotation velocity near the nuclear core. This can be used to constrain the angular momentum distribution processes, and to set an upper bound on the intensity of the magnetic field in this part of the Sun. The search for gravity modes with an original method is another topic of this dissertation. Several candidates are detected that need now to be confirmed. Gravity modes will give us a precious insight into the solar core structure and dynamics. We also use the stellar evolution code CESAM. By combining seismic data and solar modelling, we produce solar seismic models. The neutrino flux predictions from these models are partly derived on an observational basis. The comparison of these fluxes with the SNO results gives the solution to the solar neutrino puzzle: neutrinos have masses and they oscillate between different lepton flavors. This explains the deficit of detections observed since the sixties. We also work on the internal magnetic fields that take part to the dynamic processes. In particular, we start to study the impact of these fields on the neutrino production and transport. Finally, we reach the limits of the 1D stellar codes: they cannot take into account the dynamic processes efficiently. This justifies the current development of 2D or 3D codes. (author) [fr

  7. RED DWARF DYNAMO RAISES PUZZLE OVER INTERIORS OF LOWEST-MASS STARS

    Science.gov (United States)

    2002-01-01

    -years away in the constellation Aquila. Gliese 752A is a red dwarf that is one-third the mass of the Sun and slightly more than half its diameter. By contrast, VB10 is physically smaller than the planet Jupiter and only about nine percent the mass of our Sun. This very faint star is near the threshold of the lowest possible mass for a true star (.08 solar masses), below which nuclear fusion processes cannot take place according to current models. A team led by Linsky used Hubble's Goddard High Resolution Spectrograph (GHRS) to make a one-hour long exposure of VB10 on October 12, 1994. No detectable ultraviolet emission was seen until the last five minutes, when bright emission was detected in a flare. Though the star's normal surface temperature is 4,500 degrees Fahrenheit, Hubble's GHRS detected a sudden burst of 270,000 degrees Fahrenheit in the star's outer atmosphere. Linsky attributes this rapid heating to the presence of an intense, but unstable, magnetic field. THE INTERIOR WORKINGS OF A STELLAR DYNAMO Before the Hubble observation, astronomers thought magnetic fields in stars required the same dynamo process which creates magnetic fields on the Sun. In the classic solar model, heat generated by nuclear fusion reactions at the star's center escapes through a radiative zone just outside the core. The heat travels from the radiative core to the star's surface through a convection zone. In this region, heat bubbles to the surface by motions similar to boiling in a pot of water. Dynamos, which accelerate electrons to create magnetic forces, operate when the interior of a star rotates faster than the surface. Recent studies of the Sun indicate its convective zone rotates at nearly the same rate at all depths. This means the solar dynamo must operate in the more rapidly rotating radiative core just below the convective zone. The puzzle is that stars below 20 percent the mass of our Sun do not have radiative cores, but instead transport heat from their core through

  8. The Puzzling Role of CXCR4 in Human Immunodeficiency Virus Infection

    OpenAIRE

    Elisa Vicenzi, Pietro Liò, Guido Poli

    2013-01-01

    The human immunodeficiency virus type-1 (HIV-1) is the etiological agent of the acquired immunodeficiency syndrome (AIDS), a disease highly lethal in the absence of combination antiretroviral therapy. HIV infects CD4+ cells of the immune system (T cells, monocyte-macrophages and dendritic cells) via interaction with a universal primary receptor, the CD4 molecule, followed by a mandatory interaction with a second receptor (co-receptor) belonging to the chemokine receptor family. Apart from som...

  9. ESA's Rosetta mission and the puzzles that Hale-Bopp left behind

    Science.gov (United States)

    1997-04-01

    kilometres with a set of remote-sensing instruments. As the spacecraft moves around the nucleus at a very leisurely walking pace, other onboard instruments will analyse the dust and vapours, which will emanate from Comet Wirtanen with ever-increasing vigour as the Sun's rays warm it. Rosetta will drop a lander on to the comet's surface, for close inspection of its physical condition and chemical composition. The lander is a venture led by Germany, France and Italy, with participation from Austria, Finland, Hungary, Poland and the UK. As a box packed with scientific instruments and standing on three legs, the lander will be capable of anchoring itself to one spot and drilling into the surface. It may also be able to hop like a flea to visit another part of the nucleus. A combination of solar energy and electric batteries will enable operations to last for several months. "The combination of Rosetta in orbit around the comet and the lander on its surface is very powerful from a scientific point of view," says Gerhard Schwehm, ESA's project scientist for Rosetta. "We shall watch Comet Wirtanen brewing up like a volcano as it feels the heat of the Sun. In place of hazy impressions of the nucleus of a comet half hidden by its dust clouds, we shall see all the details with unprecedented clarity." Unanswered questions During and after the 1986 appearance of Halley's Comet, comet science made great progress. More recent comets have revealed important secrets to ESA's Infrared Space Observatory and to other space telescopes examining them at wavelengths unobservable from the Earth. Yet basic questions about comets remain unanswered. Just as the Rosetta Stone was the key that unlocked the meaning of Egyptian hieroglyphs, so the Rosetta spacecraft is intended to decipher the meaning of comets and their role in the origin and history of the Solar System. Here are a few of the main puzzles. * What does a comet weigh? Guesses about the density of cometary material vary widely, and only an

  10. The Annuity Puzzle Remains a Puzzle

    NARCIS (Netherlands)

    Peijnenburg, J.M.J.; Werker, Bas; Nijman, Theo

    We examine incomplete annuity menus and background risk as possible drivers of divergence from full annuitization. Contrary to what is often suggested in the literature, we find that full annuitization remains optimal if saving is possible after retirement. This holds irrespective of whether real or

  11. Puzzling out the proton radius puzzle

    Directory of Open Access Journals (Sweden)

    Mihovilovič Miha

    2014-01-01

    Full Text Available The discrepancy between the proton charge radius extracted from the muonic hydrogen Lamb shift measurement and the best present value obtained from the elastic scattering experiments, remains unexplained and represents a burning problem of today’s nuclear physics: after more than 50 years of research the radius of a basic constituent of matter is still not understood. This paper presents a summary of the best existing proton radius measurements, followed by an overview of the possible explanations for the observed inconsistency between the hydrogen and the muonic-hydrogen data. In the last part the upcoming experiments, dedicated to remeasuring the proton radius, are described.

  12. Puzzling out the proton radius puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Mihovilovič, M.; Merkel, H.; Weber, A. [Institut für Kernphysik, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 45, 55128 Mainz (Germany)

    2016-01-22

    The discrepancy between the proton charge radius extracted from the muonic hydrogen Lamb shift measurement and the best present value obtained from the elastic scattering experiments, remains unexplained and represents a burning problem of today’s nuclear physics: after more than 50 years of research the radius of a basic constituent of matter is still not understood. This paper presents a summary of the best existing proton radius measurements, followed by an overview of the possible explanations for the observed inconsistency between the hydrogen and the muonic-hydrogen data. In the last part the upcoming experiments, dedicated to remeasuring the proton radius, are described.

  13. THE PUZZLING MUTUAL ORBIT OF THE BINARY TROJAN ASTEROID (624) HEKTOR

    Energy Technology Data Exchange (ETDEWEB)

    Marchis, F.; Cuk, M. [Carl Sagan Center at the SETI Institute, Mountain View, CA 94043 (United States); Durech, J. [Astronomical Institute, Faculty of Mathematics and Physics, Charles University, Prague (Czech Republic); Castillo-Rogez, J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Vachier, F.; Berthier, J. [IMCCE-Obs de Paris, F-75014 Paris (France); Wong, M. H.; Kalas, P.; Duchene, G. [Department of Astronomy, University of California at Berkeley, Berkeley, CA 94720 (United States); Van Dam, M. A. [Flat Wavefronts, Christchurch 8140 (New Zealand); Hamanowa, H. [Hamanowa Observatory, Motomiya, Fukushima 969-1204 (Japan); Viikinkoski, M., E-mail: fmarchis@seti.org [Tampere University of Technology, FI-33101 Tampere (Finland)

    2014-03-10

    Asteroids with satellites are natural laboratories to constrain the formation and evolution of our solar system. The binary Trojan asteroid (624) Hektor is the only known Trojan asteroid to possess a small satellite. Based on W. M. Keck adaptive optics observations, we found a unique and stable orbital solution, which is uncommon in comparison to the orbits of other large multiple asteroid systems studied so far. From lightcurve observations recorded since 1957, we showed that because the large Req = 125 km primary may be made of two joint lobes, the moon could be ejecta of the low-velocity encounter, which formed the system. The inferred density of Hektor's system is comparable to the L5 Trojan doublet (617) Patroclus but due to their difference in physical properties and in reflectance spectra, both captured Trojan asteroids could have a different composition and origin.

  14. THE PUZZLING MUTUAL ORBIT OF THE BINARY TROJAN ASTEROID (624) HEKTOR

    International Nuclear Information System (INIS)

    Marchis, F.; Cuk, M.; Durech, J.; Castillo-Rogez, J.; Vachier, F.; Berthier, J.; Wong, M. H.; Kalas, P.; Duchene, G.; Van Dam, M. A.; Hamanowa, H.; Viikinkoski, M.

    2014-01-01

    Asteroids with satellites are natural laboratories to constrain the formation and evolution of our solar system. The binary Trojan asteroid (624) Hektor is the only known Trojan asteroid to possess a small satellite. Based on W. M. Keck adaptive optics observations, we found a unique and stable orbital solution, which is uncommon in comparison to the orbits of other large multiple asteroid systems studied so far. From lightcurve observations recorded since 1957, we showed that because the large Req = 125 km primary may be made of two joint lobes, the moon could be ejecta of the low-velocity encounter, which formed the system. The inferred density of Hektor's system is comparable to the L5 Trojan doublet (617) Patroclus but due to their difference in physical properties and in reflectance spectra, both captured Trojan asteroids could have a different composition and origin

  15. A picture tells 1000 words: learning teamwork in primary care.

    Science.gov (United States)

    Kelly, Martina; Bennett, Deirdre; O'Flynn, Siun; Foley, Tony

    2013-04-01

    Teamwork and patient centredness are frequently articulated concepts in medical education, but are not always explicit in the curriculum. In Ireland, recent government policy emphasises the importance of a primary care team approach to health care. We report on an appraisal of a newly introduced community-based student attachment, which focused on teamwork. To review students' experience of teamwork following a community clinical placement by examining student assignments: essays, poetry, music and art. Year-2 graduate-entry students (n = 45) spent 2 weeks with a primary care team. Attachments comprised placements with members of the primary care team, emphasising team dynamics, at the end of which students submitted a representative piece of work, which captured their learning. Essays (n = 22) were analysed using a thematic content analysis. Artwork consisted of painting, collage, photography, poetry and original music (n = 23). These were analysed using Gardner's entry points. Three core themes emerged in both written and visual work: patient centredness; communication; and an improved appreciation of the skills of other health care professionals. Students identified optimal team communication occurring when patient outcomes were prioritised. Metaphors relating to puzzles, hands and inter-connectedness feature strongly. The poems and artwork had a high impact when they were presented to tutors. Primary care team placements focus student attention on teamwork and patient centredness. Student artwork shows potential as a tool to evaluate student learning in medical education. © Blackwell Publishing Ltd 2013.

  16. Deciphering the Role of Desert Dust in the Climate Puzzle: The Mediterranean Israeli Dust Experiment (MEIDEX)

    Science.gov (United States)

    Levin, Zev; Joseph, Joachim; Mekler, Yuri; Israelevich, Peter; Ganor, Eli; Hilsenrath, Ernest; Janz, Scott

    2002-01-01

    Numerous studies have shown that aerosol particles may be one of the primary agents that can offset the climate warming induced by the increase in the amount of atmospheric greenhouse gases. Desert aerosols are probably the most abundant and massive type of aerosol particles that are present in the atmosphere worldwide. These aerosols are carried over large distances and have various global impacts. They interact with clouds, impact the efficiency of their rain production and change their optical properties. They constitute one of the primary sources of minerals for oceanic life and influence the health of coral reefs. They have direct effects on human health, especially by inducing breathing difficulties in children. It was lately discovered that desert particles carry pathogens from the Sahara desert over the Atlantic Ocean, a fact that may explain the migration of certain types of diseases. Aerosols not only absorb solar radiation but also scatter it, so that their climatic effect is influenced not only by their physical properties and height distribution but also by the reflectivity of the underlying surface. This latter property changes greatly over land and is low over ocean surfaces. Aerosol plumes are emitted from discrete, sporadic sources in the desert areas of the world and are transported worldwide by the atmosphere's wind systems. For example, Saharan dust reaches Mexico City, Florida, Ireland, Switzerland and the Mediterranean region, while Asian dust reaches Alaska, Hawaii and the continental United States. This means that in order to assess its global effects, one must observe dust from space. The Space Shuttle is a unique platform, because it flies over the major deserts of our planet, enabling measurements and remote sensing of the aerosols as they travel from source to sink regions. Such efforts must always be accompanied by in-situ data for validation and calibration, with direct sampling of the airborne particles. MEIDEX is a joint project of

  17. What cognitive strategies do orangutans (Pongo pygmaeus) use to solve a trial-unique puzzle-tube task incorporating multiple obstacles?

    Science.gov (United States)

    Tecwyn, Emma C; Thorpe, Susannah K S; Chappell, Jackie

    2012-01-01

    Apparently sophisticated behaviour during problem-solving is often the product of simple underlying mechanisms, such as associative learning or the use of procedural rules. These and other more parsimonious explanations need to be eliminated before higher-level cognitive processes such as causal reasoning or planning can be inferred. We presented three Bornean orangutans with 64 trial-unique configurations of a puzzle-tube to investigate whether they were able to consider multiple obstacles in two alternative paths, and subsequently choose the correct direction in which to move a reward in order to retrieve it. We were particularly interested in how subjects attempted to solve the task, namely which behavioural strategies they could have been using, as this is how we may begin to elucidate the cognitive mechanisms underpinning their choices. To explore this, we simulated performance outcomes across the 64 trials for various procedural rules and rule combinations that subjects may have been using based on the configuration of different obstacles. Two of the three subjects solved the task, suggesting that they were able to consider at least some of the obstacles in the puzzle-tube before executing action to retrieve the reward. This is impressive compared with the past performances of great apes on similar, arguably less complex tasks. Successful subjects may have been using a heuristic rule combination based on what they deemed to be the most relevant cue (the configuration of the puzzle-tube ends), which may be a cognitively economical strategy.

  18. Visual Puzzles, Figure Weights, and Cancellation: Some Preliminary Hypotheses on the Functional and Neural Substrates of These Three New WAIS-IV Subtests

    Science.gov (United States)

    McCrea, Simon M.; Robinson, Thomas P.

    2011-01-01

    In this study, five consecutive patients with focal strokes and/or cortical excisions were examined with the Wechsler Adult Intelligence Scale and Wechsler Memory Scale—Fourth Editions along with a comprehensive battery of other neuropsychological tasks. All five of the lesions were large and typically involved frontal, temporal, and/or parietal lobes and were lateralized to one hemisphere. The clinical case method was used to determine the cognitive neuropsychological correlates of mental rotation (Visual Puzzles), Piagetian balance beam (Figure Weights), and visual search (Cancellation) tasks. The pattern of results on Visual Puzzles and Figure Weights suggested that both subtests involve predominately right frontoparietal networks involved in visual working memory. It appeared that Visual Puzzles could also critically rely on the integrity of the left temporoparietal junction. The left temporoparietal junction could be involved in temporal ordering and integration of local elements into a nonverbal gestalt. In contrast, the Figure Weights task appears to critically involve the right temporoparietal junction involved in numerical magnitude estimation. Cancellation was sensitive to left frontotemporal lesions and not right posterior parietal lesions typical of other visual search tasks. In addition, the Cancellation subtest was sensitive to verbal search strategies and perhaps object-based attention demands, thereby constituting a unique task in comparison with previous visual search tasks. PMID:22389807

  19. Recovering the Genetic Identity of an Extinct-in-the-Wild Species: The Puzzling Case of the Alagoas Curassow.

    Science.gov (United States)

    Costa, Mariellen C; Oliveira, Paulo R R; Davanço, Paulo V; Camargo, Crisley de; Laganaro, Natasha M; Azeredo, Roberto A; Simpson, James; Silveira, Luis F; Francisco, Mercival R

    2017-01-01

    The conservation of many endangered taxa relies on hybrid identification, and when hybrids become morphologically indistinguishable from the parental species, the use of molecular markers can assign individual admixture levels. Here, we present the puzzling case of the extinct in the wild Alagoas Curassow (Pauxi mitu), whose captive population descends from only three individuals. Hybridization with the Razor-billed Curassow (P. tuberosa) began more than eight generations ago, and admixture uncertainty affects the whole population. We applied an analysis framework that combined morphological diagnostic traits, Bayesian clustering analyses using 14 microsatellite loci, and mtDNA haplotypes to assess the ancestry of all individuals that were alive from 2008 to 2012. Simulated data revealed that our microsatellites could accurately assign an individual a hybrid origin until the second backcross generation, which permitted us to identify a pure group among the older, but still reproductive animals. No wild species has ever survived such a severe bottleneck, followed by hybridization, and studying the recovery capability of the selected pure Alagoas Curassow group might provide valuable insights into biological conservation theory.

  20. Recovering the Genetic Identity of an Extinct-in-the-Wild Species: The Puzzling Case of the Alagoas Curassow.

    Directory of Open Access Journals (Sweden)

    Mariellen C Costa

    Full Text Available The conservation of many endangered taxa relies on hybrid identification, and when hybrids become morphologically indistinguishable from the parental species, the use of molecular markers can assign individual admixture levels. Here, we present the puzzling case of the extinct in the wild Alagoas Curassow (Pauxi mitu, whose captive population descends from only three individuals. Hybridization with the Razor-billed Curassow (P. tuberosa began more than eight generations ago, and admixture uncertainty affects the whole population. We applied an analysis framework that combined morphological diagnostic traits, Bayesian clustering analyses using 14 microsatellite loci, and mtDNA haplotypes to assess the ancestry of all individuals that were alive from 2008 to 2012. Simulated data revealed that our microsatellites could accurately assign an individual a hybrid origin until the second backcross generation, which permitted us to identify a pure group among the older, but still reproductive animals. No wild species has ever survived such a severe bottleneck, followed by hybridization, and studying the recovery capability of the selected pure Alagoas Curassow group might provide valuable insights into biological conservation theory.

  1. Event-by-Event Hydrodynamics+Jet Energy Loss: A Solution to the R_{AA}⊗v_{2} Puzzle.

    Science.gov (United States)

    Noronha-Hostler, Jacquelyn; Betz, Barbara; Noronha, Jorge; Gyulassy, Miklos

    2016-06-24

    High p_{T}>10  GeV elliptic flow, which is experimentally measured via the correlation between soft and hard hadrons, receives competing contributions from event-by-event fluctuations of the low-p_{T} elliptic flow and event-plane angle fluctuations in the soft sector. In this Letter, a proper account of these event-by-event fluctuations in the soft sector, modeled via viscous hydrodynamics, is combined with a jet-energy-loss model to reveal that the positive contribution from low-p_{T} v_{2} fluctuations overwhelms the negative contributions from event-plane fluctuations. This leads to an enhancement of high-p_{T}>10  GeV elliptic flow in comparison to previous calculations and provides a natural solution to the decade-long high-p_{T} R_{AA}⊗v_{2} puzzle. We also present the first theoretical calculation of high-p_{T} v_{3}, which is shown to be compatible with current LHC data. Furthermore, we discuss how short-wavelength jet-medium physics can be deconvoluted from the physics of soft, bulk event-by-event flow observables using event-shape engineering techniques.

  2. The puzzle of the 1996 Bárdarbunga, Iceland, earthquake: no volumetric component in the source mechanism

    Science.gov (United States)

    Tkalcic, Hrvoje; Dreger, Douglas S.; Foulger, Gillian R.; Julian, Bruce R.

    2009-01-01

    A volcanic earthquake with Mw 5.6 occurred beneath the Bárdarbunga caldera in Iceland on 29 September 1996. This earthquake is one of a decade-long sequence of  events at Bárdarbunga with non-double-couple mechanisms in the Global Centroid Moment Tensor catalog. Fortunately, it was recorded well by the regional-scale Iceland Hotspot Project seismic experiment. We investigated the event with a complete moment tensor inversion method using regional long-period seismic waveforms and a composite structural model. The moment tensor inversion using data from stations of the Iceland Hotspot Project yields a non-double-couple solution with a 67% vertically oriented compensated linear vector dipole component, a 32% double-couple component, and a statistically insignificant (2%) volumetric (isotropic) contraction. This indicates the absence of a net volumetric component, which is puzzling in the case of a large volcanic earthquake that apparently is not explained by shear slip on a planar fault. A possible volcanic mechanism that can produce an earthquake without a volumetric component involves two offset sources with similar but opposite volume changes. We show that although such a model cannot be ruled out, the circumstances under which it could happen are rare.

  3. The puzzle of Italian rice origin and evolution: determining genetic divergence and affinity of rice germplasm from Italy and Asia.

    Directory of Open Access Journals (Sweden)

    Xingxing Cai

    Full Text Available The characterization of genetic divergence and relationships of a set of germplasm is essential for its efficient applications in crop breeding and understanding of the origin/evolution of crop varieties from a given geographical region. As the largest rice producing country in Europe, Italy holds rice germplasm with abundant genetic diversity. Although Italian rice varieties and the traditional ones in particular have played important roles in rice production and breeding, knowledge concerning the origin and evolution of Italian traditional varieties is still limited. To solve the puzzle of Italian rice origin, we characterized genetic divergence and relationships of 348 rice varieties from Italy and Asia based on the polymorphisms of microsatellite fingerprints. We also included common wild rice O. rufipogon as a reference in the characterization. Results indicated relatively rich genetic diversity (H(e = 0.63-0.65 in Italian rice varieties. Further analyses revealed a close genetic relationship of the Italian traditional varieties with those from northern China, which provides strong genetic evidence for tracing the possible origin of early established rice varieties in Italy. These findings have significant implications for the rice breeding programs, in which appropriate germplasm can be selected from a given region and utilized for transferring unique genetic traits based on its genetic diversity and evolutionary relationships.

  4. A novel edge based embedding in medical images based on unique key generated using sudoku puzzle design.

    Science.gov (United States)

    Santhi, B; Dheeptha, B

    2016-01-01

    The field of telemedicine has gained immense momentum, owing to the need for transmitting patients' information securely. This paper puts forth a unique method for embedding data in medical images. It is based on edge based embedding and XOR coding. The algorithm proposes a novel key generation technique by utilizing the design of a sudoku puzzle to enhance the security of the transmitted message. The edge blocks of the cover image alone, are utilized to embed the payloads. The least significant bit of the pixel values are changed by XOR coding depending on the data to be embedded and the key generated. Hence the distortion in the stego image is minimized and the information is retrieved accurately. Data is embedded in the RGB planes of the cover image, thus increasing its embedding capacity. Several measures including peak signal noise ratio (PSNR), mean square error (MSE), universal image quality index (UIQI) and correlation coefficient (R) are the image quality measures that have been used to analyze the quality of the stego image. It is evident from the results that the proposed technique outperforms the former methodologies.

  5. Sc2C2@D3h(14246)-C74: A Missing Piece of the Clusterfullerene Puzzle.

    Science.gov (United States)

    Wang, Yaofeng; Tang, Qiangqiang; Feng, Lai; Chen, Ning

    2017-02-20

    Clusterfullerenes with variable carbon cages have been extensively studied in recent years. However, despite all these efforts, C 74 cage-based clusterfullerene remains a missing piece of the puzzle. Herein, we show that single-crystal X-ray crystallographic analysis unambiguously assigns the previously reported dimetallofullerene Sc 2 @C 76 to a novel carbide clusterfullerene, Sc 2 C 2 @D 3h (14246)-C 74 , the first experimentally proven clusterfullerene with a C 74 cage. In addition, Sc 2 C 2 @D 3h (14246)-C 74 was charaterized by mass spectrometry, ultraviolet-visible-near-infrared absorption spectroscopy, 45 Sc nuclear magnetic resonance, and cyclic voltammetry. Comparative studies of the motion of the carbide cluster in Sc 2 C 2 @D 3h (14246)-C 74 and Sc 2 C 2 @C 2n (n = 40-44) revealed that a combination of factors, involving both the shape and size of the cage, is crucial in dictating the cluster motion. Moreover, structural studies of D 3h (14246)-C 74 revealed that it can be easily converted to C s (10528)-C 72 and T d (19151)-C 76 cages via C 2 desertion/insertion and Stone-Wales transformation. This suggests that D 3h (14246)-C 74 might play an important role in the growth pathway of clusterfullerenes.

  6. Solving the "Personhood Jigsaw Puzzle" in Residential Care Homes for the Elderly in the Hong Kong Chinese Context.

    Science.gov (United States)

    Kong, Sui-Ting; Fang, Christine Meng-Sang; Lou, Vivian W Q

    2017-02-01

    End-of-life care studies on the nature of personhood are bourgeoning; however, the practices utilized for achieving personhood in end-of-life care, particularly in a cultural context in which interdependent being and collectivism prevail, remain underexplored. This study seeks to examine and conceptualize good practices for achieving the personhood of the dying elderly in residential care homes in a Chinese context. Twelve interviews were conducted with both medical and social care practitioners in four care homes to collect narratives of practitioners' practices. Those narratives were utilized to develop an "end-of-life case graph." Constant comparative analysis led to an understanding of the practice processes, giving rise to a process model of "solving the personhood jigsaw puzzle" that includes "understanding the person-in-relationship and person-in-time," "identifying the personhood-inhibiting experiences," and "enabling personalized care for enhanced psychosocial outcomes." Findings show how the "relational personhood" of the elderly can be maintained when physical deterioration and even death are inevitable.

  7. Two-fluid limits on stellarator performance: Explanation of three stellarator puzzles and comparison to axisymmetric plasmas

    International Nuclear Information System (INIS)

    Sugiyama, L.E.; Strauss, H.R.; Park, W.; Fu, G.Y.; Breslau, J.A.; Chen, J.

    2005-01-01

    The basic two-fluid processes, those related to the nonlinearly self-consistent diamagnetic drifts of the electrons and ions, are shown to have fundamentally different effects on the steady state and beta limits of stellarator configurations, compared to MHD predictions. Nonlinear numerical simulation shows that the ideal MHD ballooning modes and the resistive MHD ballooning and interchange modes at relatively high mode numbers, that set the most severe theoretical limits on beta in stellarators with fixed boundary, are easily stabilized by two-fluid effects at realistic parameters, including finite Larmor radius effects related to the ion diamagnetic drift. Magnetic reconnection at low-order rational magnetic surfaces, on the other hand, is enhanced through the parallel component of the two-fluid electron pressure gradient in Ohm's law. The accelerated reconnection rates may impose the true intrinsic limit on beta in stellarators, as a 'soft' or confinement mediated limit in β e , due to steady confinement degradation in the presence of large magnetic islands. Study of the corresponding axisymmetric configurations shows that the helical component of the stellarator configuration provides an important amplifying factor for these effects. The two-fluid results may explain several previously puzzling experimental observations on stellarator behavior. (author)

  8. The conundrum of Greece and the Eurozone: Puzzles, paradoxes and contradictions

    Directory of Open Access Journals (Sweden)

    Kitromilides Yiannis

    2016-01-01

    Full Text Available This paper examines three questions regarding the controversial relationship between Greece and the eurozone during the current crisis. First, why was Greece “bailed-out” in 2010? Second, why the Greek economy collapsed despite the largest “bail-out” in global financial history? Third, was the electoral mandate of the Syriza government for ending austerity while remaining in the eurozone contradictory? There are conflicting answers to all three questions and the paper compares the answers of the so called “dominant narrative” to those provided by the “counter-narrative” of the eurozone crisis. The paper reaches the following conclusions. First, the primary motivation for the “bail-out” of Greece was the maintenance of European and global financial stability. Second, although programme implementation was less successful in Greece than in other “programme” countries the catastrophic collapse of the Greek economy had more to do with the programme itself than its implementation. Third, the meaning of democratic decision-making in the Euro-group needs re-appraisal and must go beyond seeing the Greek demand of a policy reversal in the eurozone as simply a clash of democratic mandates in a 19 member monetary union. Political unity will not only improve efficiency but also democracy and accountability in eurozone policymaking.

  9. The Puzzle of Neuroimaging and Psychiatric Diagnosis: Technology and Nosology in an Evolving Discipline.

    Science.gov (United States)

    Farah, Martha J; Gillihan, Seth J

    2012-10-01

    Brain imaging provides ever more sensitive measures of structure and function relevant to human psychology and has revealed correlates for virtually every psychiatric disorder. Yet it plays no accepted role in psychiatric diagnosis beyond ruling out medical factors such as tumors or traumatic brain injuries. Why is brain imaging not used in the diagnosis of primary psychiatric disorders, such as depression, bipolar disease, schizophrenia, and ADHD? The present article addresses this question. It reviews the state of the art in psychiatric imaging, including diagnostic and other applications, and explains the nonutility of diagnostic imaging in terms of aspects of both the current state of imaging and the current nature of psychiatric nosology. The likely future path by which imaging-based diagnoses will be incorporated into psychiatry is also discussed. By reviewing one well-known attempt to use SPECT-scanning in psychiatric diagnosis, the article examines a real-world practice that illustrates several related points: the appeal of the idea of image-assisted diagnosis for physicians, patients and families, despite a lack of proven effectiveness, and the mismatch between the categories and dimensions of current nosology and those suggested by imaging.

  10. Solving the puzzle of an isolated high-Alpine drumlin: Hornkees, Austria

    Science.gov (United States)

    Lukas, Sven; Busfield, Marie

    2017-04-01

    Larger streamlined landforms, in particular drumlins, are frequently found in lowland environments where they attest to fast ice flow; they are comparatively rare in upland environments where smaller streamlined landforms (i.e. flutes) and erosional landforms (e.g. ice-moulded bedrock) are found much more prominent. We here report geomorphological and sedimentological field observations from a small drumlin formed during the last c. 200 years in the foreland of Hornkees, a small valley glacier in the Eastern Alps. This drumlin is located in the middle of the valley floor, upvalley of a bedrock obstacle, and consists of overridden and glaciotectonised outwash overlain by subglacial traction till of varying consistency. Using lithofacies analysis, clast fabric and clast shape data as well as structural measurements (e.g. of shear planes and fold axes) and in-situ soil penetrometer measurements we demonstrate that this drumlin is likely to represent one of the rare cases in upland environments where the primary mechanisms of fast flow and subglacial sediment deformation have been preserved and can thus be studied in detail. We present our dataset with the aim of generating discussion of these mechanisms and outline the significance of such rare cases as modern analogues not just for palaeo-studies, but also for our understanding of material properties from an engineering-geological standpoint.

  11. Hydroxymethylated Dioxobilins in Senescent Arabidopsis thaliana Leaves: Sign of a Puzzling Biosynthetic Intermezzo of Chlorophyll Breakdown.

    Science.gov (United States)

    Süssenbacher, Iris; Kreutz, Christoph R; Christ, Bastien; Hörtensteiner, Stefan; Kräutler, Bernhard

    2015-08-10

    1-Formyl-19-oxobilin-type tetrapyrroles are characteristic, abundant products of chlorophyll breakdown in senescent leaves. However, in some leaves, 1,19-dioxobilin-type chlorophyll catabolites (DCCs) lacking the formyl group accumulate instead. A P450 enzyme was identified in in vitro studies that removed the formyl group of a primary fluorescent chlorophyll catabolite (pFCC) and generated fluorescent DCCs. These DCCs are precursors of isomeric nonfluorescent DCCs (NDCCs). Here, we report a structural investigation of the NDCCs in senescent leaves of wild-type Arabidopsis thaliana. Four new NDCCs were characterized, two of which carried a stereoselectively added hydroxymethyl group. Such formal DCC hydroxymethylations were previously found in DCCs in leaves of a mutant of A. thaliana. They are now indicated to be a feature of chlorophyll breakdown in A. thaliana, associated with the specific in vivo deformylation of pFCC en route to NDCCs. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. INVESTIGATION OF THE PUZZLING ABUNDANCE PATTERN IN THE STARS OF THE FORNAX DWARF SPHEROIDAL GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Li Hongjie; Cui Wenyuan; Zhang Bo, E-mail: zhangbo@mail.hebtu.edu.cn [Department of Physics, Hebei Normal University, No. 20 East of South 2nd Ring Road, Shijiazhuang 050024 (China)

    2013-09-20

    Many works have found unusual characteristics of elemental abundances in nearby dwarf galaxies. This implies that there is a key factor of galactic evolution that is different from that of the Milky Way (MW). The chemical abundances of the stars in the Fornax dwarf spheroidal galaxy (Fornax dSph) provide excellent information for setting constraints on the models of galactic chemical evolution. In this work, adopting the five-component approach, we fit the abundances of the Fornax dSph stars, including {alpha} elements, iron group elements, and neutron-capture elements. For most sample stars, the relative contributions from the various processes to the elemental abundances are not usually in the MW proportions. We find that the contributions from massive stars to the primary {alpha} elements and iron group elements increase monotonically with increasing [Fe/H]. This means that the effect of the galactic wind is not strong enough to halt star formation and the contributions from the massive stars to {alpha} elements did not halt for [Fe/H] {approx}< -0.5. The average contribution ratios of various processes between the dSph stars and the MW stars monotonically decrease with increasing progenitor mass. This is important evidence of a bottom-heavy initial mass function (IMF) for the Fornax dSph, compared to the MW. Considering a bottom-heavy IMF for the dSph, the observed relations of [{alpha}/Fe] versus [Fe/H], [iron group/Fe] versus [Fe/H], and [neutron-capture/Fe] versus [Fe/H] for the dSph stars can be explained.

  13. Sacubitril/valsartan: An important piece in the therapeutic puzzle of heart failure.

    Science.gov (United States)

    Marques da Silva, Pedro; Aguiar, Carlos

    2017-09-01

    Sacubitril/valsartan (LCZ696), a supramolecular sodium salt complex of the neprilysin inhibitor prodrug sacubitril and the angiotensin receptor blocker (ARB) valsartan, was recently approved in the EU and the USA for the treatment of chronic heart failure (HF) with reduced ejection fraction (HFrEF) (NYHA class II-IV). Inhibition of chronically activated neurohormonal pathways (the renin-angiotensin-aldosterone system [RAAS] and sympathetic nervous system [SNS]) is central to the treatment of chronic HFrEF. Furthermore, enhancement of the natriuretic peptide (NP) system, with favorable cardiovascular (CV) and renal effects in HF, is a desirable therapeutic goal to complement RAAS and SNS blockade. Sacubitril/valsartan represents a novel pharmacological approach that acts by enhancing the NP system via inhibition of neprilysin (an enzyme that degrades NPs) and by suppressing the RAAS via AT1 receptor blockade, thereby producing more effective neurohormonal modulation than can be achieved with RAAS inhibition alone. In the large, randomized, double-blind PARADIGM-HF trial, replacement of an angiotensin-converting enzyme inhibitor (ACEI) (enalapril) with sacubitril/valsartan resulted in a significant improvement in morbidity and mortality in patients with HFrEF. Sacubitril/valsartan was superior to enalapril in reducing the risk of CV death or HF hospitalization (composite primary endpoint) and all-cause death, and in limiting progression of HF. Sacubitril/valsartan was generally well tolerated, with a comparable safety profile to enalapril; symptomatic hypotension was more common with sacubitril/valsartan, whereas renal dysfunction, hyperkalemia and cough were less common compared with enalapril. In summary, sacubitril/valsartan is a superior alternative to ACEIs/ARBs in the treatment of HFrEF, a recommendation that is reflected in many HF guidelines. Copyright © 2017 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. Key new pieces of the HIMU puzzle from olivines and diamond inclusions.

    Science.gov (United States)

    Weiss, Yaakov; Class, Cornelia; Goldstein, Steven L; Hanyu, Takeshi

    2016-09-29

    Mantle melting, which leads to the formation of oceanic and continental crust, together with crust recycling through plate tectonics, are the primary processes that drive the chemical differentiation of the silicate Earth. The present-day mantle, as sampled by oceanic basalts, shows large chemical and isotopic variability bounded by a few end-member compositions. Among these, the HIMU end-member (having a high U/Pb ratio, μ) has been generally considered to represent subducted/recycled basaltic oceanic crust. However, this concept has been challenged by recent studies of the mantle source of HIMU magmas. For example, analyses of olivine phenocrysts in HIMU lavas indicate derivation from the partial melting of peridotite, rather than from the pyroxenitic remnants of recycled oceanic basalt. Here we report data that elucidate the source of these lavas: high-precision trace-element analyses of olivine phenocrysts point to peridotite that has been metasomatized by carbonatite fluids. Moreover, similarities in the trace-element patterns of carbonatitic melt inclusions in diamonds and HIMU lavas indicate that the metasomatism occurred in the subcontinental lithospheric mantle, fused to the base of the continental crust and isolated from mantle convection. Taking into account evidence from sulfur isotope data for Archean to early Proterozoic surface material in the deep HIMU mantle source, a multi-stage evolution is revealed for the HIMU end-member, spanning more than half of Earth's history. Before entrainment in the convecting mantle, storage in a boundary layer, upwelling as a mantle plume and partial melting to become ocean island basalt, the HIMU source formed as Archean-early Proterozoic subduction-related carbonatite-metasomatized subcontinental lithospheric mantle.

  15. What would 5-HT do? Regional diversity of 5-HT1 receptor modulation of primary afferent neurotransmission

    OpenAIRE

    Connor, Mark

    2012-01-01

    5-HT (serotonin) is a significant modulator of sensory input to the CNS, but the only analgesics that selectively target G-protein-coupled 5-HT receptors are highly specific for treatment of headache. Two recent papers in BJP shed light on this puzzling situation by showing that primary afferent neurotransmission to the superficial layers of the spinal and trigeminal dorsal is inhibited by different subtypes of the 5-HT1 receptor – 5-HT1B(and 1D) in the trigeminal dorsal horn and 5-HT1A in th...

  16. PENGEMBANGAN PENCEGAHAN SERANGAN DISTRIBUTED DENIAL OF SERVICE (DDOS PADA SUMBER DAYA JARINGAN DENGAN INTEGRASI NETWORK BEHAVIOR ANALYSIS DAN CLIENT PUZZLE

    Directory of Open Access Journals (Sweden)

    Septian Geges

    2015-01-01

    Full Text Available Denial of Service (DoS merupakan permasalahan keamanan jaringan yang sampai saat ini terus berkembang secara dinamis. Semakin tinggi kemampuan komputasi suatu komputer penyerang, serangan DoS yang dapat dihasilkan juga semakin membahayakan. Serangan ini dapat mengakibatkan ketidakmampuan server untuk melayani service request yang sah. Karena itu serangan DoS sangat merugikan dan perlu diberikan pencegahan yang efektif. Ancaman berikutnya yang juga sangat membahayakan adalah Distributed Denial of Service (DDoS, dimana serangan ini memanfaatkan sejumlah besar komputer untuk menjalankan serangan DoS kepada server, web service, atau sumber daya jaringan lain. Mengingat resiko besar yang diakibatkan serangan DDoS ini, banyak peneliti yang terdorong untuk merancang mekanisme penga-manan sumber daya jaringan. Pada penelitian ini, penulis mengkhususkan pokok permasalahan pada pengamanan web service. Penulis mengemuka-kan sebuah mekanisme untuk mengamankan web service dengan cara melakukan filtrasi dan validasi permintaan yang diterima untuk mengakses sumber daya jaringan. Filtrasi dan validasi ini dilakukan dengan gabungan metode Network Behavior Analysis (NBA dan Client Puzzle (CP. Metode NBA menjadi lapisan pertahanan pertama untuk mendeteksi apakah sedang terjadi serangan DDoS dengan mengukur tingkat kepadatan jaringan/Network density. Dari metode NBA, didapatkan IP Address yang perlu divalidasi dengan metode CP sebagai lapisan pertahanan kedua. Apabila suatu service request sudah berhasil melewati proses filtrasi dan validasi ini, maka service request ini baru akan dilayani. Dari hasil percobaan, terbukti metode ini dapat mendeteksi serangan DDoS sekaligus menjamin bahwa service request yang sah mendapat pelayanan yang seharusnya sehingga server dapat melayani service request dengan baik.

  17. APRENDER JUGANDO CON "TEJIDOS PRECOLOMBINOS" MEDIANTE ROMPECABEZAS VIRTUALES LEARN BY PLAYING WITH "PRE-COLUMBIAN TEXTILES" THROUGH VIRTUAL PUZZLES

    Directory of Open Access Journals (Sweden)

    Diego Aracena Pizarro

    2008-09-01

    Full Text Available Este trabajo presenta un ambiente multimedia de rompecabezas sobre tejidos precolombinos de gran complejidad ornamental, expuestos en el Museo Arqueológico San Miguel de Azapa, Arica-Chile. El rompecabezas permite interaccionar de manera más entretenida y didáctica, con el objetivo de que la facilidad del uso del software permita aprender jugando, observando los intrincados símbolos y signos precolombinos que de otra manera pasan desapercibidos por no formar parte del ideario de los estudiantes actuales. El software se evaluó con alumnos de enseñanza básica y media de establecimientos educacionales de la ciudad, con el objetivo de complementar sus estudios a las asignaturas de historia que contienen temática prehispánica. Esta representación educacional fue implementada con herramienta Flash multimedia, con el propósito de estimular la parte creativa de los estudiantes y de abrir un mundo de juegos complementarios referentes al mismo tema, con la filosofía de aprender jugando.This paper presents a multimedia environment puzzle about Pre-Columbian textiles exhibiting ornamental complexities, found in the Archeological Museum San Miguel de Azapa, Arica-Chile. The software allow for an enjoyable and didactic interactive way of learning by playing, giving the users the opportunity of identifying intricate pre-Columbian symbols and signals, that otherwise would be unnoticed. The software was tested with schoolboys of ages 12 to 16 years old, from schools in Arica, with the purpose of complementing their studies in History courses containing Pre-hispanic topics. This educational software was implemented with Multimedia Flash Tool, so as to stimulate the creativity of the students, opening a world of complementary games with the philosophy of "learning by playing".

  18. Computer Games and Their Impact on Creativity of Primary Level Students in Tehran

    Directory of Open Access Journals (Sweden)

    Tahereh Mokhtari

    2016-09-01

    Full Text Available Creativity is about being sensitive to dilemmas, losses, problems, and existing errors, making propositions about and examining such issues, which finally leads to innovative findings. On the other hand, it seems that games are important in this process; since they can improve creativity of the individuals. Thus, this research pays attention to the question that whether computer games affect creativity of students at primary level in schools or not? Moreover, in this study, students of 3 main districts of Tehran municipality were studied. Based on the available data of the ministry, there were 51740 students studying in these three districts. Thus, 381 students were randomly selected as the research sample. Findings revealed that all computer games, i.e. puzzle, intellectual, and enigma, affect creativity of students at primary level in schools to different extents.

  19. PENINGKATAN KEMAMPUAN MEMBACA PETA DUNIA MENGGUNAKAN MEDIA PUZZLE BAGI SISWA KELAS VI SDN PEDALANGAN 02 KOTA SEMARANG TAHUN PELAJARAN 2014/2015

    Directory of Open Access Journals (Sweden)

    Turasmi Turasmi

    2014-06-01

    Full Text Available Action researchinthe classroomVI SDN Pedalangan 02 Semarang year 2014/2015 by using the media puzzle aimed to improve students' ability to read the world map. The way the data was collected through  observation, questionnaires, documentation of activities for students to learn and teachers through the use of game media, and students' work to determine student understanding through assessment/ evaluation. The results of prior research by the number of 38 students, who have reached the KKM (> 7 had 11 students (28.90%, while the remaining 27 (71.10% students are not yet Media puzzles, learning base map complete. Student activity in learning is also very low, with only 12 students indicated that attention well, 4 active child asks, while the other passive. Seeing this fact then do the research and show improved results in reading maps world blind. Evidenced by tests in cycle 1, indicating as many as 22 students (57.90% has reached mastery learning (> 7, while 16 students (42.10% was not finished. Increased student activity shown by 31 (81.60% students actively asked, 34 students are actively trying / learning media responds. With the results of tests on the first cycle has been no increase in yield, but not maximized. 2 Cycle to be done to improve the learning process in the first cycle and showed maximum improvement, from 38 students who have reached the KKM 35 students (92.1%, while the remaining try students (7.90% was not finished. All students (100% going to try to respond to the media or the media. Thus declared a class action meets the criteria expected in the second cycle. Suggested for educators in teaching and learning aids or media is very important, to planting concept on students. Media Puzzle is ideal to use in maps.

  20. Patient-specific puzzle implant preformed with 3D-printed rapid prototype model for combined orbital floor and medial wall fracture.

    Science.gov (United States)

    Kim, Young Chul; Min, Kyung Hyun; Choi, Jong Woo; Koh, Kyung S; Oh, Tae Suk; Jeong, Woo Shik

    2018-04-01

    The management of combined orbital floor and medial wall fractures involving the inferomedial strut is challenging due to absence of stable cornerstone. In this article, we proposed surgical strategies using customized 3D puzzle implant preformed with Rapid Prototype (RP) skull model. Retrospective review was done in 28 patients diagnosed with combined orbital floor and medial wall fracture. Using preoperative CT scans, original and mirror-imaged RP skull models for each patient were prepared and sterilized. In all patients, porous polyethylene-coated titanium mesh was premolded onto RP skull model in two ways; Customized 3D jigsaw puzzle technique was used in 15 patients with comminuted inferomedial strut, whereas individual 3D implant technique was used in each fracture for 13 patients with intact inferomedial strut. Outcomes including enophthalmos, visual acuity, and presence of diplopia were assessed and orbital volume was measured using OsiriX software preoperatively and postoperatively. Satisfactory results were achieved in both groups in terms of clinical improvements. Of 10 patients with preoperative diplopia, 9 improved in 6 months, except one with persistent symptom who underwent extraocular muscle rupture. 18 patients who had moderate to severe enophthalmos preoperatively improved, and one remained with mild degree. Orbital volume ratio, defined as volumetric ratio between affected and control orbit, decreased from 127.6% to 99.79% (p puzzle and individual reconstruction technique provide accurate restoration of combined orbital floor and medial wall fractures. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  1. The Infinity Puzzle - The story of the Higgs Boson:From QED to the LHC via Higgs and the Gang of Six

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    Rutherford and Bohr discovered the nuclear atom 100 years ago. Roughly 50 years ago a theory of this basic structure of matter was inspired by the work of Peter Higgs and others. In July 2012 the discovery "beyond reasonable doubt" of Higgs's boson, and the experimental proof of the theory, was announced and speculations about Nobel prizes mushroomed. The Economist said of Frank Close's book, The Infinity Puzzle (OUP,2012): "The Nobel Committee would be well advised to read Mr Close’s book before making their decision." This pedagogic talk reviews the ideas and the history, and assesses how the credits should be shared. The conclusions may not be what you anticipate

  2. Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects.

    Science.gov (United States)

    Chen, Wei; Qu, Mingbo; Zhou, Yong; Yang, Qing

    2018-02-23

    Chitin is a linear homopolymer of N -acetyl-β-d-glucosamines and a major structural component of insect cuticles. Chitin hydrolysis involves glycoside hydrolase family 18 (GH18) chitinases. In insects, chitin hydrolysis is essential for periodic shedding of the old cuticle ecdysis and proceeds via a pathway different from that in the well studied bacterial chitinolytic system. Group II chitinase (ChtII) is a widespread chitinolytic enzyme in insects and contains the greatest number of catalytic domains and chitin-binding domains among chitinases. In Lepidopterans, ChtII and two other chitinases, ChtI and Chi-h, are essential for chitin hydrolysis. Although ChtI and Chi-h have been well studied, the role of ChtII remains elusive. Here, we investigated the structure and enzymology of Of ChtII, a ChtII derived from the insect pest Ostrinia furnacalis We present the crystal structures of two catalytically active domains of Of ChtII, Of ChtII-C1 and Of ChtII-C2, both in unliganded form and complexed with chitooligosaccharide substrates. We found that Of ChtII-C1 and Of ChtII-C2 both possess long, deep substrate-binding clefts with endochitinase activities. Of ChtII exhibited structural characteristics within the substrate-binding cleft similar to those in Of Chi-h and Of ChtI. However, Of ChtII lacked structural elements favoring substrate binding beyond the active sites, including an extra wall structure present in Of Chi-h. Nevertheless, the numerous domains in Of ChtII may compensate for this difference; a truncation containing one catalytic domain and three chitin-binding modules ( Of ChtII-B4C1) displayed activity toward insoluble polymeric substrates that was higher than those of Of Chi-h and Of ChtI. Our observations provide the last piece of the puzzle of chitin hydrolysis in insects. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. Designing Math Trails for Enhanced by Mobile Learning Realistic Mathematics Education in Primary Education

    Directory of Open Access Journals (Sweden)

    Georgios Fesakis

    2018-05-01

    Full Text Available Seeking a systematic combination of the pedagogical model of m-learning with the Realistic Mathematics Education (RME approach, this study concerns the use of math trail as a learning activity model that can take the advantages of mobile computing devices for the design of effective learning experiences in an authentic context. The paper presents the design and the case study of the first pilot implementation of a math trail, using mobile devices for primary school students. In this math trail, the students are guided, through a digital map, to a sequence of preselected sites of a park where they solve specially designed math problems using data from the environmental context. The students measure real objects’ dimensions either with conventional instruments or by measurement applications of their tablet. According to the findings of the study, students solved the puzzles by applying mathematical knowledge, discussion and collaboration. The students applied and reinforced their knowledge through an effective and engaging learning activity. Moreover, the students were puzzled about the differences of the measurements by conventional and digital instruments and this confusion triggered social negotiation. Further research is needed for a grounded theory development about m-learning design for RME.

  4. Understanding the primary care paradigm: an experiential learning focus of the early veterinary graduate.

    Science.gov (United States)

    Dixon, William H R; Kinnison, Tierney; May, Stephen A

    2017-11-01

    At a time where high levels of stress are reported in the veterinary profession, this study explores the challenges that veterinary graduates encounter when they enter general (first opinion) practice. Participants had written reflective accounts of their 'Most Puzzling Cases' for the postgraduate Professional Key Skills module of the Certificate in Advanced Veterinary Practice, offered by the Royal Veterinary College. Reasons that a case was puzzling, or became challenging, were thematically analysed. Fifteen summaries were analysed. Three core themes were identified: 'clinical reasoning', centred on the limitations of pattern recognition and the methods used to overcome this; the 'veterinary healthcare system', focusing on the need for continuity of care, time pressure and support in the transition to practice; and the 'owner', looking at the broader clinical skills needed to succeed in general practice. Clinical reasoning was raised as an issue; discussion of when pattern recognition is not appropriate and what to do in these cases was common. A lack of experience in general practice case types, and how to best operate in the resource-constrained environment in which they present, is the likely cause of this, suggesting that a greater focus on the primary care paradigm is needed within veterinary education. © British Veterinary Association (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  5. Bringing Together Evolution on Serpentine and Polyploidy: Spatiotemporal History of the Diploid-Tetraploid Complex of Knautia arvensis (Dipsacaceae)

    Czech Academy of Sciences Publication Activity Database

    Kolář, Filip; Fér, T.; Štech, M.; Trávníček, Pavel; Dušková, E.; Schönswetter, P.; Suda, Jan

    2012-01-01

    Roč. 7, č. 7 (2012), e39988 E-ISSN 1932-6203 R&D Projects: GA AV ČR KJB600050812; GA AV ČR(CZ) KJB601110627 Institutional research plan: CEZ:AV0Z6005908 Institutional support: RVO:67985939 Keywords : serpentine spetiation * Knautia arvensis * polyploidy Subject RIV: EF - Botanics Impact factor: 3.730, year: 2012

  6. Hypernuclear weak decay puzzle

    International Nuclear Information System (INIS)

    Barbero, C.; Horvat, D.; Narancic, Z.; Krmpotic, F.; Kuo, T.T.S.; Tadic, D.

    2002-01-01

    A general shell model formalism for the nonmesonic weak decay of the hypernuclei has been developed. It involves a partial wave expansion of the emitted nucleon waves, preserves naturally the antisymmetrization between the escaping particles and the residual core, and contains as a particular case the weak Λ-core coupling formalism. The extreme particle-hole model and the quasiparticle Tamm-Dancoff approximation are explicitly worked out. It is shown that the nuclear structure manifests itself basically through the Pauli principle, and a very simple expression is derived for the neutron- and proton-induced decays rates Γ n and Γ p , which does not involve the spectroscopic factors. We use the standard strangeness-changing weak ΛN→NN transition potential which comprises the exchange of the complete pseudoscalar and vector meson octets (π,η,K,ρ,ω,K * ), taking into account some important parity-violating transition operators that are systematically omitted in the literature. The interplay between different mesons in the decay of Λ 12 C is carefully analyzed. With the commonly used parametrization in the one-meson-exchange model (OMEM), the calculated rate Γ NM =Γ n +Γ p is of the order of the free Λ decay rate Γ 0 (Γ NM th congruent with Γ 0 ) and is consistent with experiments. Yet the measurements of Γ n/p =Γ n /Γ p and of Γ p are not well accounted for by the theory (Γ n/p th p th > or approx. 0.60Γ 0 ). It is suggested that, unless additional degrees of freedom are incorporated, the OMEM parameters should be radically modified

  7. The Format Puzzle

    DEFF Research Database (Denmark)

    Knudsen, Bo Nissen

    The first volume in the printed place-name series Danmarks Stednavne (Place-names of Denmark) was published in 1922 – 12 years after the establishment of Stednavneudvalget (the Place-Name Commission) in 1910. In 2013 volume 26 is due to be published, and still only about 2/3 of the area of Denmar...

  8. Pebble Puzzle Solved

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Figure 1 In the quest to determine if a pebble was jamming the rock abrasion tool on NASA's Mars Exploration Rover Opportunity, scientists and engineers examined this up-close, approximate true-color image of the tool. The picture was taken by the rover's panoramic camera, using filters centered at 601, 535, and 482 nanometers, at 12:47 local solar time on sol 200 (August 16, 2004). Colored spots have been drawn on this image corresponding to regions where panoramic camera reflectance spectra were acquired (see chart in Figure 1). Those regions are: the grinding wheel heads (yellow); the rock abrasion tool magnets (green); the supposed pebble (red); a sunlit portion of the aluminum rock abrasion tool housing (purple); and a shadowed portion of the rock abrasion tool housing (brown). These spectra demonstrated that the composition of the supposed pebble was clearly different from that of the sunlit and shadowed portions of the rock abrasion tool, while similar to that of the dust-coated rock abrasion tool magnets and grinding heads. This led the team to conclude that the object disabling the rock abrasion tool was indeed a martian pebble.

  9. The puzzle of Chernobyl

    International Nuclear Information System (INIS)

    Fischetti, M.A.

    1986-01-01

    News of the event itself-the world's worst nuclear reactor accident-emerged in an agonizing trickle. Answers about the cause of the explosion at Chernobyl and what can be done to prevent similar catastrophes in the electric utility industry may be even slower in coming. But already top nuclear experts in the United States and Europe have put forth plausible hypotheses. The scenarios note that the accident occurred in an inherently hazardous type of reactor, little used in any country but the Soviet Union. Yet the incident has raised questions about safety measures in all reactors. As for the long-range health damage from radioactive iodine, cesium, and other products released by the Chernobyl meltdown, there is little precise knowledge. Some scientists have predicted an increase in the incidence of cancer and premature deaths in the Soviet Union and Eastern Europe in the years ahead, but they concede their estimates are only tentative. This article presents an analysis of the accident as known at the time of publication

  10. The carbon market puzzle

    International Nuclear Information System (INIS)

    Perthuis, Ch. de

    2008-01-01

    The kyoto protocol forces the developed countries which ratify it to reduce their greenhouse effect gases emissions. The reductions cost is decreased by the clean development mechanisms: the carbon markets. That is why the protocol implementation will not have a major effect on the evolution of the greenhouse effect gases for 2012. The author presents the situation and discusses the economic tools of the Kyoto protocol, the european system of quotas, the clean development mechanisms and the impacts on a future and more ambitious climatic agreement. (A.L.B.)

  11. The puzzle of homeopathy.

    Science.gov (United States)

    Reilly, D

    2001-01-01

    Homeopathy is a branch of Western medicine that has mostly been rejected by Western orthodoxy for the last 200 years because of conceptual and scientific clashes. Homeopathy uses microdoses of potential toxins to provoke defense and self-regulatory responses, rather than the more orthodox approach of blocking body reactions. This approach hints at its clinical scope: it can help, at times resolve, conditions that are intrinsically reversible rather than mechanical problems, deficiencies, or irreversible breakdowns in body functions where it is only palliative. In recent years, there has been a renaissance of interest. Public demand has soared, and with it professional interest. Approximately 20% of Scotland's general practitioners have completed basic training. This is partly occasioned by public interest in complementary medicine and a sympathy with the more mind-body approach of homeopathy, and partly by recent scientific evidence. Some homeopathic dilutions are so extreme they are dismissed by critics as only placebo. Yet trials and meta-analyses of controlled trials are pointing toward real effects, mechanism of action unknown. Clinical outcome studies suggest useful clinical impact and excellent safety. There seems to be a potential to enhance patient care by integrating the two systems.

  12. Das DNA-Puzzle

    Science.gov (United States)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsäure) beschrieben, welche das Erbgut jedes Lebewesens enthält. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es möglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  13. Amino Acid Crossword Puzzle

    Science.gov (United States)

    Sims, Paul A.

    2011-01-01

    Learning the 20 standard amino acids is an essential component of an introductory course in biochemistry. Later in the course, the students study metabolism and learn about various catabolic and anabolic pathways involving amino acids. Learning new material or concepts often is easier if one can connect the new material to what one already knows;…

  14. Spin puzzle in nucleon

    International Nuclear Information System (INIS)

    Ramachandran, R.

    1994-09-01

    The object of this brief review is to reconcile different points of view on how the spin of proton is made up from its constituents. On the basis of naive quark model with flavour symmetry such as isospin or SU(3) one finds a static description. On the contrary the local SU(3) colour symmetry gives a dynamical view. Both these views are contrasted and the role of U(1) axial anomaly and the ambiguity for the measurable spin content is discussed. (author). 16 refs, 1 fig

  15. The Birth Order Puzzle.

    Science.gov (United States)

    Zajonc, R. B.; And Others

    1979-01-01

    Discusses the controversy of the relationship between birth order and intellectual performance through a detailed evaluation of the confluence model which assumes that the rate of intellectual growth is a function of the intellectual environment within the family and associated with the special circumstances of last children. (CM)

  16. Quantum top secret. The solution of the quantum puzzle. Metamorphosis of a picture of world; Quantum top secret. Die Loesung des Quantenraetsels. Metamorphose eines Weltbildes

    Energy Technology Data Exchange (ETDEWEB)

    Wingert, M.

    2008-07-01

    Many physicists believe that because of unexplained causes, which must anyway be concerned with the quantum puzzle and the mysterious consciousness, it would be no more possible to understand the real structure of the reality - this subtle smiling of the nature, which irritates the physicists since 100 years and the disturbed the theoretical physics so much that they threw the towel. Since nature is considered as absurd, strange, and crazy - and quantum theory as very complicated. But in reality the basic experiments are of a touching simplicity, which seems only completely unintelligible in the picture of world of mechanics. For these experiments show that the concept of body of mechanics and the body conceptions of the thinking cannot at all match the structure of nature. If this is objectively taken notice of without doubting on the existence of a reality, the experiments show the real, unveiled face of the nature. Light and matter must then consist of fields, which can themselves divide by non-mechanical way, so with wholeness, comparable only with cell division and branching processes in biology. Either it is completely crazy - or the only logic interpretation, which hitherto only no physicist risked to think. For these experiments disprove the atom and elementary-particle hypothesis, the picture of world of mechanics, and also the quantum-mechanical interpretation - and indeed uniquely. This knowledge could break the Gordian knot, solve the quantum puzzle, and also give away the secret of the thinking spirit.

  17. Primary Progressive Aphasia

    Science.gov (United States)

    ... which cause different symptoms. Semantic variant primary progressive aphasia Symptoms include these difficulties: Comprehending spoken or written ... word meanings Naming objects Logopenic variant primary progressive aphasia Symptoms include: Having difficulty retrieving words Frequently pausing ...

  18. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  19. Primary ovarian malignant melanoma

    Directory of Open Access Journals (Sweden)

    Kostov Miloš

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  20. Investigating Primary Source Literacy

    Science.gov (United States)

    Archer, Joanne; Hanlon, Ann M.; Levine, Jennie A.

    2009-01-01

    Primary source research requires students to acquire specialized research skills. This paper presents results from a user study testing the effectiveness of a Web guide designed to convey the concepts behind "primary source literacy". The study also evaluated students' strengths and weaknesses when conducting primary source research. (Contains 3…

  1. Primary Hyperparathyroidism: An Overview

    Directory of Open Access Journals (Sweden)

    Jessica MacKenzie-Feder

    2011-01-01

    Full Text Available Primary hyperparathyroidism is a common condition that affects 0.3% of the general population. Primary and tertiary care specialists can encounter patients with primary hyperparathyroidism, and prompt recognition and treatment can greatly reduce morbidity and mortality from this disease. In this paper we will review the basic physiology of calcium homeostasis and then consider genetic associations as well as common etiologies and presentations of primary hyperparathyroidism. We will consider emerging trends in detection and measurement of parathyroid hormone as well as available imaging modalities for the parathyroid glands. Surgical indications and approach will be reviewed as well as medical management of primary hyperparathyroidism with bisphosphonates and calcimimetics.

  2. Normocalcemic Primary Hyperparathyroidism

    Science.gov (United States)

    Cusano, Natalie E.; Silverberg, Shonni J.; Bilezikian, John P.

    2013-01-01

    Primary hyperparathyroidism, a common endocrine disorder, is traditionally defined by hypercalcemia and elevated levels of parathyroid hormone (PTH). A newer presentation of primary hyperparathyroidism has been described over the past decade, in which PTH is elevated but serum calcium is consistently normal, in the absence of secondary causes of hyperparathyroidism, such as renal disease or vitamin D deficiency. Recognition of this phenotype of primary hyperparathyroidism, normocalcemic primary hyperparathyroidism, supports a biphasic chronological time course in some individuals in which PTH levels are first elevated but serum calcium is normal, followed by the development of frank hypercalcemia. This review focuses on the available literature regarding this newly described phenotype of primary hyperparathyroidism. PMID:23374739

  3. Worry about racial discrimination: A missing piece of the puzzle of Black-White disparities in preterm birth?

    Directory of Open Access Journals (Sweden)

    Paula Braveman

    adjustment for chronic worry (PR 1.30, 95% CI 0.93-1.81; it appeared further attenuated after adding the covariates (PR 1.17, 95% CI 0.85-1.63.Chronic worry about racial discrimination may play an important role in Black-White disparities in PTB and may help explain the puzzling and repeatedly observed greater PTB disparities among more socioeconomically-advantaged women. Although the single measure of experiences of racial discrimination used in this study precluded examination of the role of other experiences of racial discrimination, such as overt incidents, it is likely that our findings reflect an association between one or more experiences of racial discrimination and PTB. Further research should examine a range of experiences of racial discrimination, including not only chronic worry but other psychological and emotional states and both subtle and overt incidents as well. These dramatic results from a large statewide-representative study add to a growing-but not widely known-literature linking racism-related stress with physical health in general, and shed light on the links between racism-related stress and PTB specifically. Without being causally definitive, this study's findings should stimulate further research and heighten awareness of the potential role of unmeasured social variables, such as diverse experiences of racial discrimination, in racial disparities in health.

  4. Worry about racial discrimination: A missing piece of the puzzle of Black-White disparities in preterm birth?

    Science.gov (United States)

    Braveman, Paula; Heck, Katherine; Egerter, Susan; Dominguez, Tyan Parker; Rinki, Christine; Marchi, Kristen S; Curtis, Michael

    2017-01-01

    chronic worry (PR 1.30, 95% CI 0.93-1.81); it appeared further attenuated after adding the covariates (PR 1.17, 95% CI 0.85-1.63). Chronic worry about racial discrimination may play an important role in Black-White disparities in PTB and may help explain the puzzling and repeatedly observed greater PTB disparities among more socioeconomically-advantaged women. Although the single measure of experiences of racial discrimination used in this study precluded examination of the role of other experiences of racial discrimination, such as overt incidents, it is likely that our findings reflect an association between one or more experiences of racial discrimination and PTB. Further research should examine a range of experiences of racial discrimination, including not only chronic worry but other psychological and emotional states and both subtle and overt incidents as well. These dramatic results from a large statewide-representative study add to a growing-but not widely known-literature linking racism-related stress with physical health in general, and shed light on the links between racism-related stress and PTB specifically. Without being causally definitive, this study's findings should stimulate further research and heighten awareness of the potential role of unmeasured social variables, such as diverse experiences of racial discrimination, in racial disparities in health.

  5. Multiple primary cancer

    International Nuclear Information System (INIS)

    Jung, Gyu Sik; Lee, Ouk; Kim, So Sun; Kim, Ho Joon; Chun, Byung Hee; Joh, Young Duck

    1989-01-01

    It is rare for one human being to be afflicted with more than one cancer. However with further advances in therapeutic regimens, histopathologic observation, diagnostic modalities, and increased curiosity, there are increasing number of case reports of multiple primary cancer. The present study evaluates 25 histologically confirmed cases of multiple primary cancer from 1974 to 1988 at Kosin Medical Center. The most frequent site of the first primary cancer in male was stomach and in female, uterine cervix. The first primary cancer in female occurred in endocrine-related organs (breast, uterus and thyroid) in 63.6 percent. Synchronous cancers are diagnosed simultaneously or within an interval of about six months and synchronous cancers were 16 out of 25 cases. Metachronous cancers are diagnosed at interval of more than six months. There were 9 metachronous cancers and average interval between the first and second primary cancer was 22.8 months. The incidence of multiple primary cancer was 0.11 percent. The average age was 51.9 years at the time of the first primary cancer (53.1 years in male and 50.3 years in female). CT scan was most helpful in early detection of multiple primary cancers facilitating biopsy and surgery. Multiple primary cancers are beyond the medical curiosity. Early diagnosis of the disease and careful follow-up study, based on an awareness of the possibility of second cancers, will substantially increase the survival of these patients

  6. Putting the Whole Grain Puzzle Together: Health Benefits Associated with Whole Grains—Summary of American Society for Nutrition 2010 Satellite Symposium123

    Science.gov (United States)

    Jonnalagadda, Satya S.; Harnack, Lisa; Hai Liu, Rui; McKeown, Nicola; Seal, Chris; Liu, Simin; Fahey, George C.

    2011-01-01

    The symposium “Putting the Whole Grain Puzzle Together: Health Benefits Associated with Whole Grains” sponsored by the ASN brought together researchers to review the evidence regarding the health benefits associated with whole grains. Current scientific evidence indicates that whole grains play an important role in lowering the risk of chronic diseases, such as coronary heart disease, diabetes, and cancer, and also contribute to body weight management and gastrointestinal health. The essential macro- and micronutrients, along with the phytonutrients present in whole grains, synergistically contribute to their beneficial effects. Current evidence lends credence to the recommendations to incorporate whole grain foods into a healthy diet and lifestyle program. The symposium also highlighted the need for further research to examine the role of whole grain foods in disease prevention and management to gain a better understanding of their mechanisms of action. PMID:21451131

  7. Using Primary Source Documents.

    Science.gov (United States)

    Mintz, Steven

    2003-01-01

    Explores the use of primary sources when teaching about U.S. slavery. Includes primary sources from the Gilder Lehrman Documents Collection (New York Historical Society) to teach about the role of slaves in the Revolutionary War, such as a proclamation from Lord Dunmore offering freedom to slaves who joined his army. (CMK)

  8. Medics in Primary School

    Science.gov (United States)

    Press, Colin

    2003-01-01

    Some time ago a flyer on "Medics in Primary School" came the author's way. It described a programme for making placements in primary schools available to medical students. The benefits of the program to medical students and participating schools were highlighted, including opportunities to develop communication skills and demystify…

  9. Primary Sclerosing Cholangitis (PSC)

    Science.gov (United States)

    ... Legacy Society Make Gifts of Stock Donate Your Car Personal Fundraising Partnership & Support Share Your Story Spread the Word Give While You Shop Contact Us Donate Now Primary Sclerosing Cholangitis Back ...

  10. Primary cultures of astrocytes

    DEFF Research Database (Denmark)

    Lange, Sofie C; Bak, Lasse Kristoffer; Waagepetersen, Helle S

    2012-01-01

    During the past few decades of astrocyte research it has become increasingly clear that astrocytes have taken a central position in all central nervous system activities. Much of our new understanding of astrocytes has been derived from studies conducted with primary cultures of astrocytes...... subsequently found in vivo. Nevertheless, primary cultures of astrocytes are an in vitro model that does not fully mimic the complex events occurring in vivo. Here we present an overview of the numerous contributions generated by the use of primary astrocyte cultures to uncover the diverse functions...... of astrocytes. Many of these discoveries would not have been possible to achieve without the use of astrocyte cultures. Additionally, we address and discuss the concerns that have been raised regarding the use of primary cultures of astrocytes as an experimental model system....

  11. Primary Meningeal Rhabdomyosarcoma

    Science.gov (United States)

    Palta, Manisha; Riedel, Richard F.; Vredenburgh, James J.; Cummings, Thomas J.; Green, Scott; Chang, Zheng; Kirkpatrick, John P.

    2011-01-01

    Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI) demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13). Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC) systemic therapy. PMID:21772793

  12. Primary Meningeal Rhabdomyosarcoma

    Directory of Open Access Journals (Sweden)

    Manisha Palta

    2011-01-01

    Full Text Available Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13. Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC systemic therapy.

  13. Primary meningeal rhabdomyosarcoma.

    Science.gov (United States)

    Palta, Manisha; Riedel, Richard F; Vredenburgh, James J; Cummings, Thomas J; Green, Scott; Chang, Zheng; Kirkpatrick, John P

    2011-01-01

    Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI) demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13). Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC) systemic therapy.

  14. Primary Nurse - Role Evolution

    Science.gov (United States)

    Mundinger, Mary O'Neil

    1973-01-01

    Primary nursing means that each patient has an individual nurse who is responsible for assessing his nursing needs and planning and evaluating his nursing care. The article describes the advantages and problems connected with this approach to patient care. (AG)

  15. Multiple Primary Tumors

    African Journals Online (AJOL)

    2017-12-05

    Dec 5, 2017 ... Multiple primary tumors occur in clinical practice causing diagnostic dilemma. It is not very .... was estrogen receptor negative, progesterone receptor negative, and ... cervical, ovarian, and urinary bladder cancers. Multiple.

  16. Primary infertility (image)

    Science.gov (United States)

    Primary infertility is a term used to describe a couple that has never been able to conceive a pregnancy ... to do so through unprotected intercourse. Causes of infertility include a wide range of physical as well ...

  17. Unilateral exophthalmos in primary hyperthyroidism

    International Nuclear Information System (INIS)

    Park, C. Y.; Kim, Y. J.; Choi, K. O.

    1980-01-01

    The exophthalmos of Graves' disease remains a pathophysiologic and therapeutic puzzle. Its relation to the hyperthyroidism of Grave's disease is far from clarified. It is a common clinical observation that exophthalmos does not often relate temporally with the onset of hyperthyroidism. Furthermore, exophthalmos may occur in patients who have no evidence of thyroid disease. Pathologically, exophthalmos is characterized by marked lymphocytic infiltration of the retro-orbital muscles, with edema and mucopolysaccharide deposition. Recently, cellular immunity in response to retro-orbital antigens and abnormal humoral immunity are suggested for the pathogenesis of exophthalmos. We experienced 2 patients with hyperthyroidism and unilateral exophthalmos. The clinical and laboratory features of the patients are presented with review of articles, with emphasis on pathogenesis.

  18. Primary Intraorbital Ectopic Meningioma

    Science.gov (United States)

    Yokoyama, Tetsuo; Nishizawa, Shigeru; Sugiyama, Kenji; Yokota, Noki; Ohta, Seiji; Uemura, Kenichi; Hinokuma, Kaoru; Inenaga, Chikanori

    1999-01-01

    We report a case of intraorbital meningioma. Operative findings and histopathological examination revealed the tumoc to be meningothelial meningloma and to be located entirely outside the optic dura. This case demonstrates the occurrence of primary intraorbital ectopic meningioma, and the tumor was removed through a modified Dolenc approach. The primary intraorbital ectopic meningioma is discussed and the surgical approach to the orbital apex region is reviewed. ImagesFigure 1Figure 2Figure 4Figure 5 PMID:17171081

  19. Primary leiomyosarcoma of epididymis

    Directory of Open Access Journals (Sweden)

    Dillip Kumar Muduly

    2012-01-01

    Full Text Available Primary leiomyosarcomas rarely arise from epididymis. But they are the most common histopathological types of sarcoma arising from the epididymis. Primary epididymal leiomyosarcoma occurs usually in older patients. We report a young patient of 35 years presenting with leiomyosarcoma of left epididymis. He did not have any metastasis and underwent left high inguinal orchiectomy. He is on regular follow-up and disease free for last two years.

  20. Primary care ... where?

    Science.gov (United States)

    Adcock, G B

    1999-07-01

    Corporate-based nurse managed centers are not the national norm. More prevalent is the use of an occupational health or physician-directed medical model of care. The author describes how a 14-year-old primary care center at a North Carolina computer software company is just "business as usual" when viewed in the context of the company's philosophy, goals, and culture. Included are considerations for nurse practitioners interested in the successful transplantation of this primary care model to other settings.

  1. Other primary headaches

    Directory of Open Access Journals (Sweden)

    Anish Bahra

    2012-01-01

    Full Text Available The ′Other Primary Headaches′ include eight recognised benign headache disorders. Primary stabbing headache is a generally benign disorder which often co-exists with other primary headache disorders such as migraine and cluster headache. Primary cough headache is headache precipitated by valsalva; secondary cough has been reported particularly in association with posterior fossa pathology. Primary exertional headache can occur with sudden or gradual onset during, or immediately after, exercise. Similarly headache associated with sexual activity can occur with gradual evolution or sudden onset. Secondary headache is more likely with both exertional and sexual headache of sudden onset. Sudden onset headache, with maximum intensity reached within a minute, is termed thunderclap headache. A benign form of thunderclap headache exists. However, isolated primary and secondary thunderclap headache cannot be clinically differentiated. Therefore all headache of thunderclap onset should be investigated. The primary forms of the aforementioned paroxysmal headaches appear to be Indomethacin sensitive disorders. Hypnic headache is a rare disorder which is termed ′alarm clock headache′, exclusively waking patients from sleep. The disorder can be Indomethacin responsive, but can also respond to Lithium and caffeine. New daily persistent headache is a rare and often intractable headache which starts one day and persists daily thereafter for at least 3 months. The clinical syndrome more often has migrainous features or is otherwise has a chronic tension-type headache phenotype. Management is that of the clinical syndrome. Hemicrania continua straddles the disorders of migraine and the trigeminal autonomic cephalalgias and is not dealt with in this review.

  2. Proceedings of High Energy Physics Workshop ''Scalar Mesons: An Interesting Puzzle for QCD'' held at SUNY Institute of Technology, May 16-18, 2003 Published by the American Institute of Physics AIP Conference Proceedings 688 Editor: Amir H. Fariborz

    International Nuclear Information System (INIS)

    Fariborz, Amir H.

    2003-01-01

    The proceedings of the workshop: ''Scalar Mesons: An Interesting Puzzle for QCD'' contains papers that were presented at the workshop by a number of experts from around the world. It includes three main categories of Theoretical, Computational and Experimental works. The topics that are presented in this proceedings are of interest to senior and junior investigators in high energy physics, nuclear physics and computational physics, and provide most recent ideas, techniques, and directions for future research in these fields

  3. Primary Ectopic Ethmoidal Craniopharyngioma.

    Science.gov (United States)

    Preti, Andrea; Karligkiotis, Apostolos; Facco, Carla; Ottini, Giorgia; Volpi, Luca; Castelnuovo, Paolo

    2017-06-01

    Craniopharyngiomas are benign but aggressive epithelial tumors usually originating in the anterior lobe of the pituitary gland from squamous remnants of an incompletely involuted craniopharingeal duct developing from the Rathke pouch. To the authors' knowledge only 1 patient of a primary isolated ethmoidal craniopharyngioma has been reported in the literature.The authors report the case of a 17-year-old boy with a primary extracranial ethmoidal craniopharyngioma. An endoscopic endonasal approach was employed to resect the tumor. After 2 years of clinical and radiological follow-up no recurrence of disease was observed.Primary ethmoidal craniopharyngiomas are rare entities and biopsy is necessary for diagnosis. However, a preoperative assessment by means of nasal endoscopy, computed tomography scan, and enhanced magnetic resonance imaging is mandatory to better evaluate the extension and characteristics of the tumor. The endoscopic endonasal technique is a safe and effective approach for the treatment of these lesions.

  4. Primary renal synovial sarcoma

    Directory of Open Access Journals (Sweden)

    Girish D. Bakhshi

    2012-03-01

    Full Text Available Primary Renal Sarcoma is rare tumor comprising only 1% of all renal tumours. Synovial sarcomas are generally deep-seated tumors arising in the proximity of large joints of adolescents and young adults and account for 5-10% of all soft tissue tumours. Primary synovial sarcoma of kidney is rare and has poor prognosis. It can only be diagnosed by immunohistochemistry. It should be considered as a differential in sarcomatoid and spindle cell tumours. We present a case of 33-year-old female, who underwent left sided radical nephrectomy for renal tumour. Histopathology and genetic analysis diagnosed it to be primary renal synovial sarcoma. Patient underwent radiation therapy and 2 years follow up is uneventful. A brief case report with review of literature is presented.

  5. Primary headaches in children

    Directory of Open Access Journals (Sweden)

    Ajay Kumar Pan

    2015-01-01

    Full Text Available Headache is a widespread clinical problem; the prevalence is high in all age groups, from which children and teenagers are not spared. It has been reported that, as many as 75% of school-age children may experience headache infrequently, among them 10% have recurrent headaches. [1],[2] The vast majority of headaches are primary and classified as migraine, tension-type headache (TTH, cluster headache, and other trigeminal autonomic cephalgias. The type of primary headaches could usually be diagnosed by a thorough and careful history taking, and physical examination. Once the diagnosis of migraine is established and appropriate reassurance provided, a balanced and individually tailored treatment plan can be instituted. The goal of treatment includes abortive or acute pain treatment, preventive long-term treatment, and biobehavioral therapy. Knowledge of precise impact of primary headaches on child′s quality of life helps to design a proper comprehensive treatment plan.

  6. Normocalcemic primary hyperparathyroidism

    Science.gov (United States)

    Bilezikian, John P.; Silverberg, Shonni J.

    2011-01-01

    SUMMARY Primary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. The historical view of this disease describes two distinct entities marked by two eras. When primary hyperparathyroidism was first discovered about 80 years ago, it was always symptomatic with kidney stones, bone disease and marked hypercalcemia. With the advent of the multichannel autoanalyzer about 40 years ago, the clinical phenotype changed to a disorder characterized by mild hypercalcemia and the absence of classical other features of the disease. We may now be entering a 3rd era in the history of this disease in which patients are being discovered with normal total and ionized serum calcium concentrations but with parathyroid hormone levels that are consistently elevated. In this article, we describe this new entity, normocalcemic primary hyperparathyroidism, a forme fruste of the disease. PMID:20485897

  7. [Primary care in Ireland].

    Science.gov (United States)

    Sánchez-Sagrado, T

    Spanish doctors are still leaving the country to look for quality work. Ireland is not a country with many Spanish professionals but it is interesting to know its particular Health care system. Ireland is one of the countries with a national health care system, although it has a mixture of private health care insurance schemes. People have a right to health care if they have been living in Ireland at least for a year. Access to the primary care health system depends on age and income: free of charge for Category 1 and co-payments for the rest. This division generates great inequalities among the population. Primary Care doctors are self-employed, and they work independently. However, since 2001 they have tended to work in multidisciplinary teams in order to strengthen the Primary Care practice. Salary is gained from a combination of public and private incomes which are not differentiated. The role of the General Practitioner consists in the treatment of acute and chronic diseases, minor surgery, child care, etc. There is no coordination between Primary and Secondary care. Access to specialised medicine is regulated by the price of consultation. Primary Care doctors are not gatekeepers. To be able to work here, doctors must have three years of training after medical school. After that, Continuing Medical Education is compulsory, and the college of general practitioners monitors it annually. The Irish health care system does not fit into the European model. Lack of a clear separation between public and private health care generates great inequalities. The non-existence of coordination between primary and specialised care leads to inefficiencies, which Ireland cannot allow itself after a decade of economic crisis. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Thoughts on primary care.

    Science.gov (United States)

    Raskin, Lynne

    2010-01-01

    The uptake of family health teams in Ontario has been tremendous. And the creation of group practices in primary care has taken root in other provinces as well. For many people, being involved with something new is exciting. At the same time, once they are committed, they discover the challenges that can be simultaneously exhilarating and frustrating. This issue of Healthcare Quarterly offers two articles that provide interesting reflections on what has been learned so far from the perspectives of both team leadership and the team members themselves within a transforming primary care system.

  9. Primary lymphoma of the brain

    Science.gov (United States)

    Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; Lymphoma - brain ... The cause of primary brain lymphoma is not known. People with a weakened immune system are at high risk for primary lymphoma of the brain. ...

  10. anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV decays in QCD factorization and possible puzzles

    International Nuclear Information System (INIS)

    Chang, Qin; Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling

    2016-01-01

    Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B_d_,_s → D"*_d_,_sV decays, the tensions between theoretical results and experimental measurements, i.e. the ''R_d_s"V puzzle'' and ''D*V (or R_V_/_l _a_n_t_i _ν__l_) puzzle'', are presented after detailed analyses. For the anti B"*_d_,_s → D_d_,_sV decays, they have relatively large branching fractions of the order >or similar O(10"-"9) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R_d_s"'"V and R"'_V_/_l _a_n_t_i _ν__l_. More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

  11. Neutron-deuteron analyzing power data at En = 21 MeV and the energy dependence of the three-nucleon analyzing power puzzle

    Science.gov (United States)

    Weisel, G. J.; Tornow, W.; Esterline, J. H.

    2015-08-01

    We present measurements of n-d analyzing power, {A}y(θ ), at En = 21.0 MeV. The experiment produces neutrons via the 2H(d, n)3He reaction and uses a deuterated liquid-scintillator center detector and six pairs of liquid-scintillator neutron side detectors. Elastic neutron scattering events are identified by using time-of-flight techniques and by setting a gate in the center-detector pulse-height spectrum. Beam polarization is monitored by using a high-pressure helium gas scintillator. The n-d {A}y(θ ) data at 21.0 MeV show a significant discrepancy with the results of rigorous three-body calculations and are consistent with data taken previously by us at 19.0 and 22.5 MeV. We review the overall energy dependence of the three-nucleon analyzing power puzzle in neutron-deuteron elastic scattering, using the best data available. We find that the relative difference between calculations and data is nearly constant at 25% up to En = 22.5 MeV.

  12. The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process.

    Science.gov (United States)

    Hashem, Yaser; Frank, Joachim

    2018-03-01

    Translation initiation in eukaryotes is a highly regulated and rate-limiting process. It results in the assembly and disassembly of numerous transient and intermediate complexes involving over a dozen eukaryotic initiation factors (eIFs). This process culminates in the accommodation of a start codon marking the beginning of an open reading frame at the appropriate ribosomal site. Although this process has been extensively studied by hundreds of groups for nearly half a century, it has been only recently, especially during the last decade, that we have gained deeper insight into the mechanics of the eukaryotic translation initiation process. This advance in knowledge is due in part to the contributions of structural biology, which have shed light on the molecular mechanics underlying the different functions of various eukaryotic initiation factors. In this review, we focus exclusively on the contribution of structural biology to the understanding of the eukaryotic initiation process, a long-standing jigsaw puzzle that is just starting to yield the bigger picture. Expected final online publication date for the Annual Review of Biophysics Volume 47 is May 20, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

  13. Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential.

    Science.gov (United States)

    de Matos, Ana Marta; de Macedo, Maria Paula; Rauter, Amélia Pilar

    2018-01-01

    Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two age-related amyloid diseases that affect millions of people worldwide. Broadly supported by epidemiological data, the higher incidence of AD among type 2 diabetic patients led to the recognition of T2D as a tangible risk factor for the development of AD. Indeed, there is now growing evidence on brain structural and functional abnormalities arising from brain insulin resistance and deficiency, ultimately highlighting the need for new approaches capable of preventing the development of AD in type 2 diabetic patients. This review provides an update on overlapping pathophysiological mechanisms and pathways in T2D and AD, such as amyloidogenic events, oxidative stress, endothelial dysfunction, aberrant enzymatic activity, and even shared genetic background. These events will be presented as puzzle pieces put together, thus establishing potential therapeutic targets for drug discovery and development against T2D and diabetes-induced cognitive decline-a heavyweight contributor to the increasing incidence of dementia in developed countries. Hoping to pave the way in this direction, we will present some of the most promising and well-studied drug leads with potential against both pathologies, including their respective bioactivity reports, mechanisms of action, and structure-activity relationships. © 2017 Wiley Periodicals, Inc.

  14. Improved proton-deuteron phase-shift analysis above the deuteron breakup threshold and the three-nucleon analyzing-power puzzle

    International Nuclear Information System (INIS)

    Tornow, W.; Kievsky, A.; Witala, H.

    2002-01-01

    Using the existing high-accuracy data for proton-deuteron and deuteron-proton elastic scattering, a phase-shift analysis has been performed in the laboratory proton energy range from E p = 4 to 10 MeV The AV 18-based proton-deuteron phase shifts were used as starting values in the phase-shift search procedure. The low-partial wave phase shifts, especially the 4 P j phase shifts have been determined very precisely, thus providing valuable guidance for theoretical approaches to tackle the quest for a successful description of three-nucleon bound-state and continuum observables in a more efficient and consistent way. Furthermore, it was found that the 4 P 1/2 phase shift and the mixing parameter ε 3/2 - determined in the present analysis cannot be generated by 3 P j nucleon-nucleon interactions which are consistent with two-nucleon analyzing power data. Therefore, three-nucleon forces must play an essential role in resolving the long-standing three-nucleon analyzing-power puzzle. Refs. 44 (author)

  15. Surgery of Primary Melanomas

    Directory of Open Access Journals (Sweden)

    Piotr Rutkowski

    2010-05-01

    Full Text Available Surgery remains the mainstay of melanoma therapy, regardless of the tumor site. Only the early diagnosis combined with proper surgical therapy currently gives patients affected by this malignancy the chance for a full cure. The main goal of surgical therapy is to provide the local control of the disease and to secure long-term survival of the patient without reasonable functional and esthetic impairment. The recommended method of biopsy—excisional biopsy, as an initial diagnostic and, to some extent, therapeutic procedure—is performed under local anesthesia as an elliptical incision with visual clear margins of 1–3 mm and with some mm of subcutaneous tissue. The extent of radical excision of the primary tumor (or scar after excisional biopsy is based on the histopathologic characteristics of the primary tumor and usually consists of 1–2 cm margins with primary closure. The philosophy behind conducted randomized clinical trials has been to find the most conservative surgical approach that is able to guarantee the same results as more demolitive treatment. This has been the background of the trials designed to define the correct margins of excision around a primary cutaneous melanoma. Much less definition can be dedicated to the surgical management of patients with non-cutaneous melanomas.

  16. Surgery of Primary Melanomas

    Energy Technology Data Exchange (ETDEWEB)

    Rutkowski, Piotr, E-mail: rutkowskip@coi.waw.pl; Zdzienicki, Marcin; Nowecki, Zbigniew I. [Soft Tissue/Bone Sarcoma and Melanoma Department, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland); Akkooi, Alexander C. J. van [Erasmus University Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2010-05-11

    Surgery remains the mainstay of melanoma therapy, regardless of the tumor site. Only the early diagnosis combined with proper surgical therapy currently gives patients affected by this malignancy the chance for a full cure. The main goal of surgical therapy is to provide the local control of the disease and to secure long-term survival of the patient without reasonable functional and esthetic impairment. The recommended method of biopsy—excisional biopsy, as an initial diagnostic and, to some extent, therapeutic procedure—is performed under local anesthesia as an elliptical incision with visual clear margins of 1–3 mm and with some mm of subcutaneous tissue. The extent of radical excision of the primary tumor (or scar after excisional biopsy) is based on the histopathologic characteristics of the primary tumor and usually consists of 1–2 cm margins with primary closure. The philosophy behind conducted randomized clinical trials has been to find the most conservative surgical approach that is able to guarantee the same results as more demolitive treatment. This has been the background of the trials designed to define the correct margins of excision around a primary cutaneous melanoma. Much less definition can be dedicated to the surgical management of patients with non-cutaneous melanomas.

  17. Surgery of Primary Melanomas

    International Nuclear Information System (INIS)

    Rutkowski, Piotr; Zdzienicki, Marcin; Nowecki, Zbigniew I.; Akkooi, Alexander C. J. van

    2010-01-01

    Surgery remains the mainstay of melanoma therapy, regardless of the tumor site. Only the early diagnosis combined with proper surgical therapy currently gives patients affected by this malignancy the chance for a full cure. The main goal of surgical therapy is to provide the local control of the disease and to secure long-term survival of the patient without reasonable functional and esthetic impairment. The recommended method of biopsy—excisional biopsy, as an initial diagnostic and, to some extent, therapeutic procedure—is performed under local anesthesia as an elliptical incision with visual clear margins of 1–3 mm and with some mm of subcutaneous tissue. The extent of radical excision of the primary tumor (or scar after excisional biopsy) is based on the histopathologic characteristics of the primary tumor and usually consists of 1–2 cm margins with primary closure. The philosophy behind conducted randomized clinical trials has been to find the most conservative surgical approach that is able to guarantee the same results as more demolitive treatment. This has been the background of the trials designed to define the correct margins of excision around a primary cutaneous melanoma. Much less definition can be dedicated to the surgical management of patients with non-cutaneous melanomas

  18. Primary intestinal lymphangiectasia.

    Science.gov (United States)

    Suresh, N; Ganesh, R; Sankar, Janani; Sathiyasekaran, Malathi

    2009-10-01

    Primary intestinal lymphangiectasia (PIL) is a rare disease of intestinal lymphatics presenting with hypoproteinemia, bilateral lower limb edema, ascites, and protein losing enteropathy. We report a series of 4 children from Chennai, India presenting with anasarca, recurrent diarrhea, hypoproteinemia and confirmatory features of PIL on endoscopy and histopathology.

  19. Healthcare is primary

    Directory of Open Access Journals (Sweden)

    Raman Kumar

    2015-01-01

    Full Text Available India is undergoing a rapid transformation in terms of governance, administrative reforms, newer policy develoment, and social movements. India is also considered one of the most vibrant economies in the world. The current discourse in public space is dominated by issues such as economic development, security, corruption free governance, gender equity, and women safety. Healthcare though remains a pressing need of population; seems to have taken a backseat. In the era of decreasing subsidies and cautious investment in social sectors, the 2 nd National Conference on Family Medicine and Primary Care 2015 (FMPC brought a focus on "healthcare" in India. The theme of this conference was "Healthcare is Primary." The conference participants discussed on the theme of why healthcare should be a national priority and why strong primary care should remain at the center of healthcare delivery system. The experts recommended that India needs to strengthen the "general health system" instead of focusing on disease based vertical programs. Public health system should have capacity and skill pool to be able to deliver person centered comprehensive health services to the community. Proactive implementation of policies towards human resource in health is the need of the hour. As the draft National Health Policy 2015 is being debated, "family medicine" (academic primary care, the unfinished agenda of National Health Policy 2002, remains a priority area of implementation.

  20. Multiple Primary Tumors

    African Journals Online (AJOL)

    2018-02-07

    Feb 7, 2018 ... breast and ascending colon. KEYWORDS: Carcinoid, colorectal cancer, metachronous, synchronous. Multiple Primary Tumors. MA Adeyanju, AA Ilori. Address for correspondence: Dr. MA Adeyanju,. Department of Surgery, Federal Medical Centre, Ebute Metta,. Lagos, Nigeria. E-mail: mbadeyanju@yahoo.

  1. Primary malignant intramedullary lymphoma

    International Nuclear Information System (INIS)

    Orrego P, E.; Heinicke Y, H.; Arbaiza A, D.; Yepez R, V.

    1999-01-01

    A case of primary malignant intramedullary lymphoma, localized in the dorsal part of the spinal cord is presented. The clinical symptoms were associated with motor and sensitive deficit. Clinical investigations excluded the presence of lymphoma in other locations in the central nervous system and the extra neural organs. Postoperative radiotherapy and chemotherapy improved relict neurological symptoms. (authors)

  2. Primary black holes

    International Nuclear Information System (INIS)

    Novikov, I.; Polnarev, A.

    1981-01-01

    Proves are searched for of the formation of the so-called primary black holes at the very origin of the universe. The black holes would weigh less than 10 13 kg. The formation of a primary black hole is conditional on strong fluctuations of the gravitational field corresponding roughly to a half of the fluctuation maximally permissible by the general relativity theory. Only big fluctuations of the gravitational field can overcome the forces of the hot gas pressure and compress the originally expanding matter into a black hole. Low-mass black holes have a temperature exceeding that of the black holes formed from stars. A quantum process of particle formation, the so-called evaporation takes place in the strong gravitational field of a black hole. The lower the mass of the black hole, the shorter the evaporation time. The analyses of processes taking place during the evaporation of low-mass primary black holes show that only a very small proportion of the total mass of the matter in the universe could turn into primary black holes. (M.D.)

  3. Familial primary hyperparathyroidism

    International Nuclear Information System (INIS)

    Iqbal, P.; Javed, R.

    2007-01-01

    A case of primary hyperparathyroidism in a 17 years old female is described. Patient presented with severe abdominal and pelvic pains associate with discomfort. Diagnostic testing revealed multiple upper and lower limb fractures and renal stones. Case was self limiting. Patient's condition resolved on parathyroidectomy for adenoma and partial thyroidectomy. Follow-up showed familial links. (author)

  4. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  5. Primary cosmic ray flux

    Energy Technology Data Exchange (ETDEWEB)

    Stanev, Todor

    2001-05-01

    We discuss the primary cosmic ray flux from the point of view of particle interactions and production of atmospheric neutrinos. The overall normalization of the cosmic ray flux and its time variations and site dependence are major ingredients of the atmospheric neutrino predictions and the basis for the derivation of the neutrino oscillation parameters.

  6. in primary care

    African Journals Online (AJOL)

    Claire van Deventer

    Keywords: child HIV, doctor involvement, primary health care, quality improvement ... expertise increased, PHC facilities are now expected to be able to .... organised patient documentation were revisited. .... Review: what can we learn from quality ... South Pacific: Review of evidence and lessons from an innovative.

  7. [Primary and secondary encopresis].

    Science.gov (United States)

    Lang-Langer, Ellen

    2007-01-01

    While the difficulty of the child to part with its faeces in primary encopresis is linked to the incapability to experience the object as separated and independent from himself, secondary encopresis is a progressed psychical state of development. In this case we have to deal with regression caused by conflict. Two case-studies show clearly the differences.

  8. Spirometry in primary care

    Science.gov (United States)

    Coates, Allan L; Graham, Brian L; McFadden, Robin G; McParland, Colm; Moosa, Dilshad; Provencher, Steeve; Road, Jeremy

    2013-01-01

    Canadian Thoracic Society (CTS) clinical guidelines for asthma and chronic obstructive pulmonary disease (COPD) specify that spirometry should be used to diagnose these diseases. Given the burden of asthma and COPD, most people with these diseases will be diagnosed in the primary care setting. The present CTS position statement was developed to provide guidance on key factors affecting the quality of spirometry testing in the primary care setting. The present statement may also be used to inform and guide the accreditation process for spirometry in each province. Although many of the principles discussed are equally applicable to pulmonary function laboratories and interpretation of tests by respirologists, they are held to a higher standard and are outside the scope of the present statement. PMID:23457669

  9. Cancer of unknown primary

    DEFF Research Database (Denmark)

    Dyrvig, Anne-Kirstine; Yderstræde, Knud Bonnet; Gerke, Oke

    2017-01-01

    210 (38.7%) had a CUP diagnosis confirmed. Within the cohort, 347 patients (64.0%) had a registration in CR matching with the NPR registration. Exposure to diagnostic procedures included biopsy (n = 439, 81.0%) and image modalities (n = 532, 98.2%). Survival was poor with 67 (12.4%) individuals alive...... after 4 years.The validity of a CUP diagnosis in NPR was low when using data from CR as reference. More than half the suspected CUP patients had a previous cancer diagnosis with CUP being the most frequent. Patients were diagnosed in compliance with guidelines indicating high external validity, but less...... than 1 quarter had their primary identified and the 1-year survival was approximately 20%. Research is needed to develop efficacious methods for primary detection....

  10. Primary omental pregnancy

    International Nuclear Information System (INIS)

    Yildizhan, R.; Kurdoglu, M.; Kolusari, A.; Erten, R.

    2008-01-01

    Omental pregnancy is a rare form of ectopic pregnancy and can be seen primarily or secondary to a tubal pregnancy. A 25-yeal-old woman presented with abdominal distention with pain and anemia without vaginal bleeding. After a provisional diagnosis of ruptured ectopic pregnancy, laparotomy was performed. On surgical exploration, the bilateral tubes and ovaries were intact, however, an omental pregnancy was detected as the cause of hemoperitoneum. Partial omentectomy was performed. Although most cases are secondary, presented here is an additional case of primary omental pregnancy at 12 weeks according to Studdiford's criteria. Histological evidence of neovascularization into the supporting tissue confirmed our diagnosis. A primary omental pregnancy should always be considered as a possible explanation for severe hemoperitoneum in ectopic pregnancies presenting with acute abdomen and with intact adnexes on surgical exploration. (author)

  11. Basics of primary immunodeficiencies

    Directory of Open Access Journals (Sweden)

    Claudia Hernández-Martínez

    2016-05-01

    Full Text Available Primary immunodeficiencies (PID are a heterogeneous group of inherited disorders, the etiology are the defects in the development or function of the immune system. The principal PID manifestations are the infections in early age, malignancy and diseases of immune dysregulation as autoimmunity and allergy. PIDs are genetics disorders and most of them are inherited as autosomal recessive, also this group of diseases is more prevalent in males and in childhood. The antibody immunodeficiency is the PID more common in adults. The more frequent disorders are the infections in the respiratory tract, abscesses, candidiasis, diarrhea, BCGosis etc. Initial approach included a complete blood count and quantification of immunoglobulins. The delay in diagnosis could be explained due to a perception that the recurrent infections are normal process or think that they are exclusively of childhood. The early diagnosis of PID by primary care physicians is important to opportune treatment and better prognosis.

  12. [Primary care in France].

    Science.gov (United States)

    Sánchez-Sagrado, T

    2016-01-01

    The poor planning of health care professionals in Spain has led to an exodus of doctors leaving the country. France is one of the chosen countries for Spanish doctors to develop their professional career. The French health care system belongs to the Bismarck model. In this model, health care system is financed jointly by workers and employers through payroll deduction. The right to health care is linked to the job, and provision of services is done by sickness-funds controlled by the Government. Primary care in France is quite different from Spanish primary care. General practitioners are independent workers who have the right to set up a practice anywhere in France. This lack of regulation has generated a great problem of "medical desertification" with problems of health care access and inequalities in health. French doctors do not want to work in rural areas or outside cities because "they are not value for money". Medical salary is linked to professional activity. The role of doctors is to give punctual care. Team work team does not exist, and coordination between primary and secondary care is lacking. Access to diagnostic tests, hospitals and specialists is unlimited. Duplicity of services, adverse events and inefficiencies are the norm. Patients can freely choose their doctor, and they have a co-payment for visits and hospital care settings. Two years training is required to become a general practitioner. After that, continuing medical education is compulsory, but it is not regulated. Although the French medical Health System was named by the WHO in 2000 as the best health care system in the world, is it not that good. While primary care in Spain has room for improvement, there is a long way for France to be like Spain. Copyright © 2015 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  13. [Primary care in Italy].

    Science.gov (United States)

    Sánchez-Sagrado, T

    Italy is not a country where Spanish doctors emigrate, as there is an over-supply of health care professionals. The Italian Servizio Sanitario Nazionale has some differences compared to the Spanish National Health System. The Servizio Sanitario Nazionale is financed by national and regional taxes and co-payments. There are taxes earmarked for health, and Primary Care receives 50% of the total funds. Italian citizens and residents in Italy have the right to free health cover. However, there are co-payments for laboratory and imaging tests, pharmaceuticals, specialist ambulatory services, and emergencies. Co-payments vary in the different regions. The provision of services is regional, and thus fragmentation and major inequities are the norm. Doctors in Primary Care are self-employed and from 2000 onwards, there are incentives to work in multidisciplinary teams. Salary is regulated by a national contract and it is the sum of per-capita payments and extra resources for specific activities. Responsibilities are similar to those of Spanish professionals. However, medical care is more personal. Relationships between Primary Care and specialised care depend on the doctors' relationships. Primary Care doctors are gatekeepers for specialised care, except for gynaecology, obstetrics and paediatrics. Specialised training is compulsory in order to work as general practitioner. The Italian Health Care System is a national health system like the Spanish one. However, health care professionals are self-employed, and there are co-payments. In spite of co-payments, Italians have one of the highest average life expectancy, and they support a universal and publicly funded health-care system. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  14. Primary Tunnel Junction Thermometry

    International Nuclear Information System (INIS)

    Pekola, Jukka P.; Holmqvist, Tommy; Meschke, Matthias

    2008-01-01

    We describe the concept and experimental demonstration of primary thermometry based on a four-probe measurement of a single tunnel junction embedded within four arrays of junctions. We show that in this configuration random sample specific and environment-related errors can be avoided. This method relates temperature directly to Boltzmann constant, which will form the basis of the definition of temperature and realization of official temperature scales in the future

  15. Primary stabbing headache.

    Science.gov (United States)

    Pareja, Juan A; Sjaastad, Ottar

    2010-01-01

    Primary stabbing headache is characterized by transient, cephalic ultrashort stabs of pain. It is a frequent complaint with a prevalence of 35.2%, a female preponderance, and a mean age of onset of 28 years (Vågå study). Attacks are generally characterized by moderate to severe, jabbing or stabbing pain, lasting from a fraction of a second to 3s. Attack frequency is generally low, with one or a few attacks per day. The paroxysms generally occur spontaneously, during daytime. Most patients exhibit a sporadic pattern, with an erratic, unpredictable alternation between symptomatic and non-symptomatic periods. Paroxysms are almost invariably unilateral. Temporal and fronto-ocular areas are most frequently affected. Attacks tend to move from one area to another, in either the same or the opposite hemicranium. Jabs may be accompanied by a shock-like feeling and even by head movement - "jolts" -or vocalization. On rare occasions, conjunctival hemorrhage and monocular vision loss have been described as associated features. Primary stabbing headache may concur, synchronously or independently, with other primary headaches. In contrast to what is the case in adults, in childhood it is not usually associated with other headaches. Treatment is rarely necessary. Indomethacin, 75-150 mg daily, may seem to be of some avail. Celecoxib, nifedipine, melatonin, and gabapentin have been reported to be effective in isolated cases and small series of patients. The drug studies need corroboration. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. [Primary headache and depression].

    Science.gov (United States)

    Gesztelyi, Gyöngyi

    2004-11-28

    Primary headaches--mainly tension-type headache and migraine--affect a significant portion of the population. Depression is also highly prevalent. The co-existence of a primary headache and depression in the same patient therefore might be a coincidence due to the high prevalence of these conditions, but there might be a causal relationship between them, or headaches and depression might have a common background. This review of the literature summarizes the features of the relationship between primary headaches and depression. Depression is more prevalent in headache patients than in the headache-free population. Prospective epidemiological studies suggest a common genetic, biochemical or environmental background behind primary headaches and depression. This theory is supported by the role of the same neurotransmitter systems (mostly serotonin and dopamine) in headaches as well as in depression. Comorbid depression is associated with female gender, higher age, and higher frequency of headaches. Most depression inventories--questionnaires used to screen for the severity of depressive symptoms--contain transdiagnostic items, therefore their use in their original form is limited in organic diseases: due to the somatic items they might overestimate the severity of depression. When examining a headache patient special attention should be paid to the recognition of comorbid depression. The diagnosis of suspected mood disorder could be supported by using simple screening methods, such as the original or the abbreviated versions of standard depression inventories, but the final diagnosis of major depression needs psychiatric evaluation. Quality of life of the headache patient is affected not only by the characteristics of pain (frequency, duration, severity) but also by the disability caused by headache and the associating mood disorder. Recognizing coexisting mood disorder and disability helps to make the best treatment choice for the acute and preventive treatment of

  17. A new theory of cryptogenic stroke and its relationship to patent foramen ovale; or, the puzzle of the missing extra risk.

    Science.gov (United States)

    Eggers, Arnold E

    2006-01-01

    Cryptogenic stroke (or stroke of undetermined cause) is a common cause of stroke and is statistically associated with patent foramen ovale (PFO). The largest study of cryptogenic stroke is the Homma study, which is a sub-study of the WARSS trial; it produced the following data: cryptogenic stroke patients with and without PFO, when treated with either aspirin or warfarin, all had identical recurrence rates. This is puzzling because it seems as though there ought to have been some extra risk in one of the two groups under one of the two treatments. How could everything come out the same? A review of the epidemiology of cryptogenic stroke shows that, compared to patients with stroke of determined cause, cryptogenic stroke patients are a little younger and have lower doses of the usual risk factors (hypertension and diabetes mellitus) but more PFO. Cryptogenic strokes appear to be embolic strokes from an unknown source. A previously published article setting forth a hypothetical theory of stress-induced stroke was used to analyze these data. It is suggested that stress can induce episodic systemic platelet activation and hypercoagulability, which causes transient thrombus formation and subsequent embolization on both the arterial and venous sides of the circulation; the latter requires a PFO to cause a stroke (paradoxical embolism). The sum of these two mechanisms explains cryptogenic stroke. The PFO subset of cryptogenic stroke includes patients with both early and late stage disease who have an aggregate risk approximately equal to that of patients without PFO. Cryptogenic stroke is part of the disease of stress-induced cerebrovascular disease. Aspirin and warfarin have already been shown to be equally effective in secondary prevention of ischemic stroke.

  18. Simultaneous explanation of the R{sub K} and R{sub D{sup (}{sup ∗}{sup )}} puzzles: a model analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Bhubanjyoti [Physique des Particules, Université de Montréal,C.P. 6128, succ. centre-ville, Montréal, QC, H3C 3J7 (Canada); Department of Physics and Astronomy, Wayne State University,Detroit, MI 48201 (United States); Datta, Alakabha [Department of Physics and Astronomy, University of Mississippi,108 Lewis Hall, Oxford, MS 38677-1848 (United States); Guévin, Jean-Pascal; London, David [Physique des Particules, Université de Montréal,C.P. 6128, succ. centre-ville, Montréal, QC, H3C 3J7 (Canada); Watanabe, Ryoutaro [Physique des Particules, Université de Montréal,C.P. 6128, succ. centre-ville, Montréal, QC, H3C 3J7 (Canada); Center for Theoretical Physics of the Universe, Institute for Basic Science (IBS),Daejeon 305-811 (Korea, Republic of)

    2017-01-04

    R{sub K} and R{sub D{sup (}{sup ∗}{sup )}} are two B-decay measurements that presently exhibit discrepancies with the SM. Recently, using an effective field theory approach, it was demonstrated that a new-physics model can simultaneously explain both the R{sub K} and R{sub D{sup (}{sup ∗}{sup )}} puzzles. There are two UV completions that can give rise to the effective Lagrangian: (i) VB: a vector boson that transforms as an SU(2){sub L} triplet, as in the SM, (ii) U{sub 1}: an SU(2){sub L}-singlet vector leptoquark. In this paper, we examine these models individually. A key point is that VB contributes to B{sub s}{sup 0}-B̄{sub s}{sup 0} mixing and τ→3μ, while U{sub 1} does not. We show that, when constraints from these processes are taken into account, the VB model is just barely viable. It predicts B(τ{sup −}→μ{sup −}μ{sup +}μ{sup −})≃2.1×10{sup −8}. This is measurable at Belle II and LHCb, and therefore constitutes a smoking-gun signal of VB. For U{sub 1}, there are several observables that may point to this model. Perhaps the most interesting is the lepton-flavor-violating decay υ(3S)→μτ, which has previously been overlooked in the literature. U{sub 1} predicts B(υ(3S)→μτ)|{sub max}=8.0×10{sup −7}. Thus, if a large value of B(υ(3S)→μτ) is observed — and this should be measurable at Belle II — the U{sub 1} model would be indicated.

  19. Protein folding: Over half a century lasting quest. Comment on "There and back again: Two views on the protein folding puzzle" by Alexei V. Finkelstein et al.

    Science.gov (United States)

    Krokhotin, Andrey; Dokholyan, Nikolay V.

    2017-07-01

    Most proteins fold into unique three-dimensional (3D) structures that determine their biological functions, such as catalytic activity or macromolecular binding. Misfolded proteins can pose a threat through aberrant interactions with other proteins leading to a number of diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis [1,2]. What does determine 3D structure of proteins? The first clue to this question came more than fifty years ago when Anfinsen demonstrated that unfolded proteins can spontaneously fold to their native 3D structures [3,4]. Anfinsen's experiments lead to the conclusion that proteins fold to unique native structure corresponding to the stable and kinetically accessible free energy minimum, and protein native structure is solely determined by its amino acid sequence. The question of how exactly proteins find their free energy minimum proved to be a difficult problem. One of the puzzles, initially pointed out by Levinthal, was an inconsistency between observed protein folding times and theoretical estimates. A self-avoiding polymer model of a globular protein of 100-residues length on a cubic lattice can sample at least 1047 states. Based on the assumption that conformational sampling occurs at the highest vibrational mode of proteins (∼picoseconds), predicted folding time by searching among all the possible conformations leads to ∼1027 years (much larger than the age of the universe) [5]. In contrast, observed protein folding time range from microseconds to minutes. Due to tremendous theoretical progress in protein folding field that has been achieved in past decades, the source of this inconsistency is currently understood that is thoroughly described in the review by Finkelstein et al. [6].

  20. Localization of primary aldosteronism

    International Nuclear Information System (INIS)

    Pagny, J.Y.; Chatellier, G.; Raynaud, A.; Plouin, P.F.; Corvol, P.

    1988-01-01

    After diagnosis of primary aldosteronism on the basis of biochemical evidence, the detection of the tumour is of crucial importance in the management of the disease. The efficacy of CT-Scan, Iodo-Cholesterol Scintigraphy, digitalized phlebography, adrenal vein sampling for steroid measurements (AVS), and Nuclear Magnetic Resonance (NMR) in 160 hypertensive patients with primary aldosteronism was reviewed. Diagnosis of Conn's adenoma (n=96) or Adrenal Hyperplasia (n=40) was confirmed by surgery or at least two concordant tumour localization tests. Scintigraphy gave a correct diagnosis in 53% of the 51 exams, CT-Scan in 82% of the 85 exams, and phlebography in 79% of 61 exams. Plasma Aldosterone/ Cortisol ratio was 5 times higher on the side of adenoma in 55% of the 47 cases but this ratio was also present in 23% of 22 patients with adrenal hyperplasia. Each procedure exhibited few false positive and false negative cases. NMR performed in 15 patients with Conn's adenoma identified all the cases. But tumours displayed a signal close to the liver signal and identical to the normal adrenal. These results and the risk of invasive procedure (failure of catheterization of the right adrenal vein (n=6) and adrenal haematoma (n=2) lead to propose a schema of exploration of patients with primary aldosteronism. The CT-Scan could be performed at the first step once the biological diagnosis confirmed. Phlebography and AVS will be performed only if tumour was less than 1 cm at the CT-Scan despite important biological abnormalities. This schema requires to be validated by a prospective evaluation [fr