Differential flatness properties and multivariable adaptive control of ovarian system dynamics
Rigatos, Gerasimos
2016-12-01
The ovarian system exhibits nonlinear dynamics which is modeled by a set of coupled nonlinear differential equations. The paper proposes adaptive fuzzy control based on differential flatness theory for the complex dynamics of the ovarian system. It is proven that the dynamic model of the ovarian system, having as state variables the LH and the FSH hormones and their derivatives, is a differentially flat one. This means that all its state variables and its control inputs can be described as differential functions of the flat output. By exploiting differential flatness properties the system's dynamic model is written in the multivariable linear canonical (Brunovsky) form, for which the design of a state feedback controller becomes possible. After this transformation, the new control inputs of the system contain unknown nonlinear parts, which are identified with the use of neurofuzzy approximators. The learning procedure for these estimators is determined by the requirement the first derivative of the closed-loop's Lyapunov function to be a negative one. Moreover, Lyapunov stability analysis shows that H-infinity tracking performance is succeeded for the feedback control loop and this assures improved robustness to the aforementioned model uncertainty as well as to external perturbations. The efficiency of the proposed adaptive fuzzy control scheme is confirmed through simulation experiments.
Dynamics of partial differential equations
Wayne, C Eugene
2015-01-01
This book contains two review articles on the dynamics of partial differential equations that deal with closely related topics but can be read independently. Wayne reviews recent results on the global dynamics of the two-dimensional Navier-Stokes equations. This system exhibits stable vortex solutions: the topic of Wayne's contribution is how solutions that start from arbitrary initial conditions evolve towards stable vortices. Weinstein considers the dynamics of localized states in nonlinear Schrodinger and Gross-Pitaevskii equations that describe many optical and quantum systems. In this contribution, Weinstein reviews recent bifurcations results of solitary waves, their linear and nonlinear stability properties, and results about radiation damping where waves lose energy through radiation. The articles, written independently, are combined into one volume to showcase the tools of dynamical systems theory at work in explaining qualitative phenomena associated with two classes of partial differential equ...
Dynamic optimization and differential games
Friesz, Terry L
2010-01-01
Dynamic Optimization and Differential Games has been written to address the increasing number of Operations Research and Management Science problems that involve the explicit consideration of time and of gaming among multiple agents. With end-of-chapter exercises throughout, it is a book that can be used both as a reference and as a textbook. It will be useful as a guide to engineers, operations researchers, applied mathematicians and social scientists whose work involves both the theoretical and computational aspects of dynamic optimization and differential games. Included throughout the text are detailed explanations of several original dynamic and game-theoretic mathematical models which are of particular relevance in today's technologically-driven-global economy: revenue management, oligopoly pricing, production planning, supply chain management, dynamic traffic assignment and dynamic congestion pricing. The book emphasizes deterministic theory, computational tools and applications associated with the stu...
Bernardino de la Serna, Jorge; Orädd, Greger; Bagatolli, Luis
2009-01-01
The composition of pulmonary surfactant membranes and films has evolved to support a complex lateral structure, including segregation of ordered/disordered phases maintained up to physiological temperatures. In this study, we have analyzed the temperature-dependent dynamic properties of native...... surfactant membranes and membranes reconstituted from two surfactant hydrophobic fractions (i.e., all the lipids plus the hydrophobic proteins SP-B and SP-C, or only the total lipid fraction). These preparations show micrometer-sized fluid ordered/disordered phase coexistence, associated with a broad...... from the two types of surfactant hydrophobic extract. These latter results suggest that lipid dynamics are similar in the coexisting fluid phases observed by fluorescence microscopy. Additionally, it is found that surfactant proteins significantly reduce the average intramolecular lipid mobility...
Hybrid Differential Dynamic Programming with Stochastic Search
Aziz, Jonathan; Parker, Jeffrey; Englander, Jacob
2016-01-01
Differential dynamic programming (DDP) has been demonstrated as a viable approach to low-thrust trajectory optimization, namely with the recent success of NASAs Dawn mission. The Dawn trajectory was designed with the DDP-based Static Dynamic Optimal Control algorithm used in the Mystic software. Another recently developed method, Hybrid Differential Dynamic Programming (HDDP) is a variant of the standard DDP formulation that leverages both first-order and second-order state transition matrices in addition to nonlinear programming (NLP) techniques. Areas of improvement over standard DDP include constraint handling, convergence properties, continuous dynamics, and multi-phase capability. DDP is a gradient based method and will converge to a solution nearby an initial guess. In this study, monotonic basin hopping (MBH) is employed as a stochastic search method to overcome this limitation, by augmenting the HDDP algorithm for a wider search of the solution space.
Differential dynamic logics - automated theorem proving for hybrid systems
Platzer, André
2008-01-01
Hybrid systems are models for complex physical systems and are defined as dynamical systems with interacting discrete transitions and continuous evolutions along differential equations. With the goal of developing a theoretical and practical foundation for deductive verification of hybrid systems, we introduce differential dynamic logic as a new logic with which correctness properties of hybrid systems with parameterized system dynamics can be specified and verified naturally. As a verificati...
The Painlevé property for partial differential equations
Weiss, John; Tabor, M.; Carnevale, George
1983-03-01
In this paper we define the Painlevé property for partial differential equations and show how it determines, in a remarkably simple manner, the integrability, the Bäcklund transforms, the linearizing transforms, and the Lax pairs of three well-known partial differential equations (Burgers' equation, KdV equation, and the modified KdV equation). This indicates that the Painlevé property may provide a unified description of integrable behavior in dynamical systems (ordinary and partial differential equations), while, at the same time, providing an efficient method for determining the integrability of particular systems.
Introduction to differential equations with dynamical systems
Campbell, Stephen L
2011-01-01
Many textbooks on differential equations are written to be interesting to the teacher rather than the student. Introduction to Differential Equations with Dynamical Systems is directed toward students. This concise and up-to-date textbook addresses the challenges that undergraduate mathematics, engineering, and science students experience during a first course on differential equations. And, while covering all the standard parts of the subject, the book emphasizes linear constant coefficient equations and applications, including the topics essential to engineering students. Stephen Cam
Dynamic data analysis modeling data with differential equations
Ramsay, James
2017-01-01
This text focuses on the use of smoothing methods for developing and estimating differential equations following recent developments in functional data analysis and building on techniques described in Ramsay and Silverman (2005) Functional Data Analysis. The central concept of a dynamical system as a buffer that translates sudden changes in input into smooth controlled output responses has led to applications of previously analyzed data, opening up entirely new opportunities for dynamical systems. The technical level has been kept low so that those with little or no exposure to differential equations as modeling objects can be brought into this data analysis landscape. There are already many texts on the mathematical properties of ordinary differential equations, or dynamic models, and there is a large literature distributed over many fields on models for real world processes consisting of differential equations. However, a researcher interested in fitting such a model to data, or a statistician interested in...
Cell Division, Differentiation and Dynamic Clustering
Kaneko, K; Kaneko, Kunihiko; Yomo, Tetsuya
1993-01-01
A novel mechanism for cell differentiation is proposed, based on the dynamic clustering in a globally coupled chaotic system. A simple model with metabolic reaction, active transport of chemicals from media, and cell division is found to show three successive stages with the growth of the number of cells; coherent growth, dynamic clustering, and fixed cell differentiation. At the last stage, disparity in activities, germ line segregation, somatic cell differentiation, and homeochaotic stability against external perturbation are found. Our results, in consistency with the experiments of the preceding paper, imply that cell differentiation can occur without a spatial pattern. From dynamical systems viewpoint, the new concept of ``open chaos" is proposed, as a novel and general scenario for systems with growing numbers of elements, also seen in economics and sociology.A
Sparse dynamics for partial differential equations.
Schaeffer, Hayden; Caflisch, Russel; Hauck, Cory D; Osher, Stanley
2013-04-23
We investigate the approximate dynamics of several differential equations when the solutions are restricted to a sparse subset of a given basis. The restriction is enforced at every time step by simply applying soft thresholding to the coefficients of the basis approximation. By reducing or compressing the information needed to represent the solution at every step, only the essential dynamics are represented. In many cases, there are natural bases derived from the differential equations, which promote sparsity. We find that our method successfully reduces the dynamics of convection equations, diffusion equations, weak shocks, and vorticity equations with high-frequency source terms.
Dynamical Properties of Interaction Data
Bramson, Aaron
2015-01-01
Network dynamics are typically presented as a time series of network properties captured at each period. The current approach examines the dynamical properties of transmission via novel measures on an integrated, temporally extended network representation of interaction data across time. Because it encodes time and interactions as network connections, static network measures can be applied to this "temporal web" to reveal features of the dynamics themselves. Here we provide the technical details and apply it to agent-based implementations of the well-known SEIR and SEIS epidemiological models.
The dynamics of crude oil price differentials
Fattouh, Bassam [The Oxford Institute for Energy Studies, 57 Woodstock Road, Oxford OX2 6FA (United Kingdom)
2010-03-15
Crude oil price differentials are modelled as a two-regime threshold autoregressive (TAR) process using the method proposed by Caner and Hansen [Caner, M., Hansen, B.E. Threshold autoregression with a unit root. Econometrica 2001; 69; 1555-1596.]. While standard unit root tests suggest that the prices of crude oil of different varieties move closely together such that their price differential is stationary, the TAR results indicate strong evidence of threshold effects in the adjustment process to the long-run equilibrium. These findings suggest that crude oil prices are linked and thus at the very general level, the oil market is 'one great pool' (Adelman, M.A. International oil agreements. The Energy Journal 1984; 5; 1-9.). However, differences in the dynamics of adjustment suggest that within this one pool, oil markets are not necessarily integrated in every time period and hence the dynamics of crude oil price differentials may not follow a stationary process at all times. Although the development of a liquid futures market around the crude oil benchmarks has helped make some distant markets more unified, arbitrage is not costless or risk-free and temporary breakdowns in the benchmarks can lead to decoupling of crude oil prices. (author)
Properties of dynamical electromagnetic metamaterials
Padilla, Willie J.; Averitt, Richard D.
2017-08-01
Electromagnetic metamaterials consist of two or three dimensional arrays of tailored metallic and/or dielectric inclusions and provide unprecedented sub-wavelength control over light-matter interactions. Metamaterials are fashioned to yield a specific response to the electric and magnetic components of light and may be treated as effective media, described by effective optical constants {μ }{{eff}} and {{ɛ }}{{eff}}, and have realized a multitude of exotic properties difficult to achieve with natural materials. An inductive-capacitive unit cell geometry provides enhanced values of optical constants, as well as the ability to dynamically control the novel responses exhibited by electromagnetic metamaterials. The ability of metamaterials to achieve real-time dynamic properties has realized novel applications and has made them relevant for the next revolution in advanced materials and related devices.
Homogenizing atomic dynamics by fractional differential equations
Tang, Shaoqiang; Ying, Yuping
2017-10-01
In this paper, we propose two ways to construct fractional differential equations (FDE) for approximating atomic chain dynamics. Taking harmonic chain as an example, we add a power function of fractional order to Taylor expansion of the dispersion relation, and determine the parameters by matching two selected wave numbers. This approximate function leads to an FDE after considering both directions for wave propagation. As an alternative, we consider the symbol of the force term, and approximate it by a similar function. It also induces an FDE. Both approaches produce excellent agreement with the harmonic chain dynamics. The accuracy may be improved by optimizing the selected wave numbers, or starting with higher order Taylor expansions. When resolved in the lattice constant, the resulting FDE's faithfully reproduce the lattice dynamics. When resolved in a coarse grid instead, they systematically generate homogenized algorithms. Numerical tests are performed to verify the proposed approaches. Moreover, FDE's are also constructed for diatomic chain and anharmonic lattice, to illustrate the generality of the proposed approaches.
2008-01-01
Using functional derivative technique in quantum field theory, the algebraic dy-namics approach for solution of ordinary differential evolution equations was gen-eralized to treat partial differential evolution equations. The partial differential evo-lution equations were lifted to the corresponding functional partial differential equations in functional space by introducing the time translation operator. The functional partial differential evolution equations were solved by algebraic dynam-ics. The algebraic dynamics solutions are analytical in Taylor series in terms of both initial functions and time. Based on the exact analytical solutions, a new nu-merical algorithm—algebraic dynamics algorithm was proposed for partial differ-ential evolution equations. The difficulty of and the way out for the algorithm were discussed. The application of the approach to and computer numerical experi-ments on the nonlinear Burgers equation and meteorological advection equation indicate that the algebraic dynamics approach and algebraic dynamics algorithm are effective to the solution of nonlinear partial differential evolution equations both analytically and numerically.
Quantitative Map of Proteome Dynamics during Neuronal Differentiation
Frese, Christian K; Mikhaylova, Marina; Stucchi, Riccardo; Gautier, Violette; Liu, Qingyang; Mohammed, Shabaz; Heck, Albert J R; Altelaar, A F Maarten; Hoogenraad, Casper C
2017-01-01
Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth, dendritogenesis, and synapse formation. To systematically profile proteome dynamics throughout neuronal differentiation, we took cultured rat hip
WANG Shundin; ZHANG Hua
2008-01-01
Using functional derivative technique In quantum field theory,the algebraic dy-namics approach for solution of ordinary differential evolution equations was gen-eralized to treat partial differential evolution equations.The partial differential evo-lution equations were lifted to the corresponding functional partial differential equations in functional space by Introducing the time translation operator.The functional partial differential evolution equations were solved by algebraic dynam-ics.The algebraic dynamics solutions are analytical In Taylor series In terms of both initial functions and time.Based on the exact analytical solutions,a new nu-merical algorithm-algebraic dynamics algorithm was proposed for partial differ-ential evolution equations.The difficulty of and the way out for the algorithm were discussed.The application of the approach to and computer numerical experi-ments on the nonlinear Burgers equation and meteorological advection equation indicate that the algebraic dynamics approach and algebraic dynamics algorithm are effective to the solution of nonlinear partial differential evolution equations both analytically and numerically.
Differential Electronic Nose in On-Line Dynamic Measurements
Osowski S.
2014-12-01
Full Text Available The paper presents application of differential electronic nose in the dynamic (on-line volatile measurement. First we compare the classical nose employing only one sensor array and its extension in the differential form containing two sensor arrays working in differential mode. We show that differential nose performs better at changing environmental conditions, especially the temperature, and well performs in the dynamic mode of operation. We show its application in recognition of different brands of tobacco
Dynamic properties of ceramic materials
Grady, D.E. [Sandia National Labs., Albuquerque, NM (United States). Experimental Impact Physics Dept.
1995-02-01
The present study offers new data and analysis on the transient shock strength and equation-of-state properties of ceramics. Various dynamic data on nine high strength ceramics are provided with wave profile measurements, through velocity interferometry techniques, the principal observable. Compressive failure in the shock wave front, with emphasis on brittle versus ductile mechanisms of deformation, is examined in some detail. Extensive spall strength data are provided and related to the theoretical spall strength, and to energy-based theories of the spall process. Failure waves, as a mechanism of deformation in the transient shock process, are examined. Strength and equation-of-state analysis of shock data on silicon carbide, boron carbide, tungsten carbide, silicon dioxide and aluminum nitride is presented with particular emphasis on phase transition properties for the latter two. Wave profile measurements on selected ceramics are investigated for evidence of rate sensitive elastic precursor decay in the shock front failure process.
Differentiable dynamical systems an introduction to structural stability and hyperbolicity
Wen, Lan
2016-01-01
This is a graduate text in differentiable dynamical systems. It focuses on structural stability and hyperbolicity, a topic that is central to the field. Starting with the basic concepts of dynamical systems, analyzing the historic systems of the Smale horseshoe, Anosov toral automorphisms, and the solenoid attractor, the book develops the hyperbolic theory first for hyperbolic fixed points and then for general hyperbolic sets. The problems of stable manifolds, structural stability, and shadowing property are investigated, which lead to a highlight of the book, the \\Omega-stability theorem of Smale. While the content is rather standard, a key objective of the book is to present a thorough treatment for some tough material that has remained an obstacle to teaching and learning the subject matter. The treatment is straightforward and hence could be particularly suitable for self-study. Selected solutions are available electronically for instructors only. Please send email to textbooks@ams.org for more informatio...
First-order partial differential equations in classical dynamics
Smith, B. R.
2009-12-01
Carathèodory's classic work on the calculus of variations explores in depth the connection between ordinary differential equations and first-order partial differential equations. The n second-order ordinary differential equations of a classical dynamical system reduce to a single first-order differential equation in 2n independent variables. The general solution of first-order partial differential equations touches on many concepts central to graduate-level courses in analytical dynamics including the Hamiltonian, Lagrange and Poisson brackets, and the Hamilton-Jacobi equation. For all but the simplest dynamical systems the solution requires one or more of these techniques. Three elementary dynamical problems (uniform acceleration, harmonic motion, and cyclotron motion) can be solved directly from the appropriate first-order partial differential equation without the use of advanced methods. The process offers an unusual perspective on classical dynamics, which is readily accessible to intermediate students who are not yet fully conversant with advanced approaches.
A DYNAMIC EVALUATION MODEL OF MINERAL RESOURCE PROPERTY
芮建伟; 冯志亮
2000-01-01
Based on the value theory of mineral resource, a dynamic evaluation model of mineral resource property is erected, which not only takes the factors of extractions into consideration but also those of explorations. The solution process of the model is described and the differential solution is presented. Then the paper comes to the conclusion that the differential solution is also the optimal depletion path of the resource.
Dynamic properties of composite cemented clay
蔡袁强; 梁旭
2004-01-01
In this work,the dynamic properties of composite cemented clay under a wide range of strains were studied considering the effect of different mixing ratio and the change of confining pressures through dynamic triaxial test. A simple and practical method to estimate the dynamic elastic modulus and damping ratio is proposed in this paper and a related empirical normalized formula is also presented. The results provide useful guidelines for preliminary estimation of cement requirements to improve the dynamic properties of clays.
A theory of differentiation with dynamic clustering
Kaneko, K; Kaneko, Kunihiko; Yomo, Tetsuya
1995-01-01
A novel theory for cell differentiation is proposed, based on simulations with interacting artificial cells which have metabolic networks within, and divide into two when the final product is accumulated. Results of simulations with coupled chemical networks and division process lead to the following scenario of the differentiation: Up to some numbers of cells, divisions bring about almost identical cells with synchronized metabolic oscillations. As the number is increased the oscillations lose the synchrony, leading to groups of cells with different phases of oscillations. At later stage this differentiation is fixed in time, and cells spilt into groups with different chemical constituents spontaneously, which are transmitted to daughter cells by cell divisions. Hierarchical differentiation, origin of stem cells, and anomalous differentiation by transplantations are also discussed with relevance to real biological experimental results. (Keywords: differentiation, metabolic network, cell division, clustering,...
Modeling tree crown dynamics with 3D partial differential equations.
Beyer, Robert; Letort, Véronique; Cournède, Paul-Henry
2014-01-01
We characterize a tree's spatial foliage distribution by the local leaf area density. Considering this spatially continuous variable allows to describe the spatiotemporal evolution of the tree crown by means of 3D partial differential equations. These offer a framework to rigorously take locally and adaptively acting effects into account, notably the growth toward light. Biomass production through photosynthesis and the allocation to foliage and wood are readily included in this model framework. The system of equations stands out due to its inherent dynamic property of self-organization and spontaneous adaptation, generating complex behavior from even only a few parameters. The density-based approach yields spatially structured tree crowns without relying on detailed geometry. We present the methodological fundamentals of such a modeling approach and discuss further prospects and applications.
Modeling Tree Crown Dynamics with 3D Partial Differential Equations
Robert eBeyer
2014-07-01
Full Text Available We characterize a tree's spatial foliage distribution by the local leaf area density. Considering this spatially continuous variable allows to describe the spatiotemporal evolution of the tree crown by means of 3D partial differential equations. These offer a framework to rigorously take locally and adaptively acting effects into account, notably the growth towards light. Biomass production through photosynthesis and the allocation to foliage and wood are readily included in this model framework. The system of equations stands out due to its inherent dynamic property of self-organization and spontaneous adaptation, generating complex behavior from even only a few parameters. The density-based approach yields spatially structured tree crowns without relying on detailed geometry. We present the methodological fundamentals of such a modeling approach and discuss further prospects and applications.
The Incidence of Differential Commercial Property Taxes: Empirical Evidence
Man, Joyce Y.
1995-01-01
Analysis of the effects of property tax differentials on commercial real estate values in and around cities. Examination of sales data from the Phoenix area (1985-88) shows that effective property tax differentials have a significant negative effect on commercial real estate.
WANG Shunjin; ZHANG Hua
2006-01-01
The problem of preserving fidelity in numerical computation of nonlinear ordinary differential equations is studied in terms of preserving local differential structure and approximating global integration structure of the dynamical system.The ordinary differential equations are lifted to the corresponding partial differential equations in the framework of algebraic dynamics,and a new algorithm-algebraic dynamics algorithm is proposed based on the exact analytical solutions of the ordinary differential equations by the algebraic dynamics method.In the new algorithm,the time evolution of the ordinary differential system is described locally by the time translation operator and globally by the time evolution operator.The exact analytical piece-like solution of the ordinary differential equations is expressd in terms of Taylor series with a local convergent radius,and its finite order truncation leads to the new numerical algorithm with a controllable precision better than Runge Kutta Algorithm and Symplectic Geometric Algorithm.
Transcriptome dynamics during human erythroid differentiation and development.
Yang, Yadong; Wang, Hai; Chang, Kai-Hsin; Qu, Hongzhu; Zhang, Zhaojun; Xiong, Qian; Qi, Heyuan; Cui, Peng; Lin, Qiang; Ruan, Xiuyan; Yang, Yaran; Li, Yajuan; Shu, Chang; Li, Quanzhen; Wakeland, Edward K; Yan, Jiangwei; Hu, Songnian; Fang, Xiangdong
2013-01-01
To explore the mechanisms controlling erythroid differentiation and development, we analyzed the genome-wide transcription dynamics occurring during the differentiation of human embryonic stem cells (HESCs) into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencing technology. HESCs and erythroid cells at three developmental stages: ESER (embryonic), FLER (fetal), and PBER (adult) were analyzed. Our findings revealed that the number of expressed genes decreased during differentiation, whereas the total expression intensity increased. At each of the three transitions (HESCs-ESERs, ESERs-FLERs, and FLERs-PBERs), many differentially expressed genes were observed, which were involved in maintaining pluripotency, early erythroid specification, rapid cell growth, and cell-cell adhesion and interaction. We also discovered dynamic networks and their central nodes in each transition. Our study provides a fundamental basis for further investigation of erythroid differentiation and development, and has implications in using ESERs for transfusion product in clinical settings.
Long-Term Dynamics of Autonomous Fractional Differential Equations
Liu, Tao; Xu, Wei; Xu, Yong; Han, Qun
This paper aims to investigate long-term dynamic behaviors of autonomous fractional differential equations with effective numerical method. The long-term dynamic behaviors predict where systems are heading after long-term evolution. We make some modification and transplant cell mapping methods to autonomous fractional differential equations. The mapping time duration of cell mapping is enlarged to deal with the long memory effect. Three illustrative examples, i.e. fractional Lotka-Volterra equation, fractional van der Pol oscillator and fractional Duffing equation, are studied with our revised generalized cell mapping method. We obtain long-term dynamics, such as attractors, basins of attraction, and saddles. Compared with some existing stability and numerical results, the validity of our method is verified. Furthermore, we find that the fractional order has its effect on the long-term dynamics of autonomous fractional differential equations.
Dynamics of intrinsic electrophysiological properties in spinal cord neurones
Russo, R E; Hounsgaard, J
1999-01-01
. The intrinsic response properties of spinal neurones--determined by the particular set and distribution of voltage sensitive channels and their dynamic non-linear interactions--show a high degree of functional specialisation as reflected by the differences of intrinsic response patterns in different cell types....... Specialised, cell specific electrophysiological phenotypes gradually differentiate during development and are continuously adjusted in the adult animal by metabotropic synaptic interactions and activity-dependent plasticity to meet a broad range of functional demands....
Topology in Dynamics, Differential Equations, and Data
Day, Sarah; Vandervorst, Robertus C. A. M.; Wanner, Thomas
2016-11-01
This special issue is devoted to showcasing recent uses of topological methods in the study of dynamical behavior and the analysis of both numerical and experimental data. The twelve original research papers span a wide spectrum of results from abstract index theories, over homology- and persistence-based data analysis techniques, to computer-assisted proof techniques based on topological fixed point arguments.
Categorical properties of topological and differentiable stacks
Carchedi, D.J.
2011-01-01
The focus of this PhD research is on the theory of topological and differentiable stacks. There are two main themes of this research. The first, is the creation of the theory of compactly generated stacks, which solve many categorical shortcomings of the theory of classical topological stacks. In pa
Uncertain dynamical systems: A differential game approach
Gutman, S.
1976-01-01
A class of dynamical systems in a conflict situation is formulated and discussed, and the formulation is applied to the study of an important class of systems in the presence of uncertainty. The uncertainty is deterministic and the only assumption is that its value belongs to a known compact set. Asymptotic stability is fully discussed with application to variable structure and model reference control systems.
Static and dynamic properties of Fibonacci multilayers
Machado, L. D.; Bezerra, C. G.; Correa, M. A.; Chesman, C.; Pearson, J. E.; Hoffmann, A.
2013-05-01
We theoretically investigate static and dynamic properties of quasiperiodic magnetic multilayers. We considered identical ferromagnetic layers separated by non-magnetic spacers with two different thicknesses chosen based on the Fibonacci sequence. Using parameters for Fe/Cr, the minimum energy was determined and the equilibrium magnetization directions found were used to calculate magnetoresistance curves. Regarding dynamic behavior, ferromagnetic resonance (FMR) curves were calculated using an approximation known from the literature. Our numerical results illustrate the effects of quasiperiodicity on the static and dynamic properties of these structures.
Extrapolation methods for dynamic partial differential equations
Turkel, E.
1978-01-01
Several extrapolation procedures are presented for increasing the order of accuracy in time for evolutionary partial differential equations. These formulas are based on finite difference schemes in both the spatial and temporal directions. On practical grounds the methods are restricted to schemes that are fourth order in time and either second, fourth or sixth order in space. For hyperbolic problems the second order in space methods are not useful while the fourth order methods offer no advantage over the Kreiss-Oliger method unless very fine meshes are used. Advantages are first achieved using sixth order methods in space coupled with fourth order accuracy in time. Computational results are presented confirming the analytic discussions.
Dynamics of the skeletal muscle secretome during myoblast differentiation
Henningsen, Jeanette; Rigbolt, Kristoffer T G; Blagoev, Blagoy
2010-01-01
of the intracellular levels of members of the semaphorin family and their corresponding secretion dynamics demonstrated that the release of secreted proteins is tightly regulated by the secretory pathway, the stability of the protein, and/or the processing of secreted proteins. Finally, we provide 299 unique...... proteomics platform to investigate the factors secreted during the differentiation of murine C2C12 skeletal muscle cells. Using triple encoding stable isotope labeling by amino acids in cell culture, we compared the secretomes at three different time points of muscle differentiation and followed the dynamics...
Cellular Proteome Dynamics during Differentiation of Human Primary Myoblasts
Le Bihan, Marie-Catherine; Barrio, Inigo; Mortensen, Tenna Pavia;
2015-01-01
and the complex temporal protein dynamics accompanying the differentiation of primary human muscle cells remain poorly understood. Here, we demonstrate the advantages of applying a MS-based quantitative approach, stable isotope labeling by amino acids in cell culture (SILAC), for studying human myogenesis...... dynamic expression profiles during the course of myogenic differentiation and quantified 2240 proteins, 243 of which were regulated. These changes in protein expression occurred in sequential waves and underlined vast reprogramming in key processes governing cell fate decisions, i.e., cell cycle...
Differential equations, dynamical systems, and an introduction to chaos
Smale, Stephen; Devaney, Robert L
2003-01-01
Thirty years in the making, this revised text by three of the world''s leading mathematicians covers the dynamical aspects of ordinary differential equations. it explores the relations between dynamical systems and certain fields outside pure mathematics, and has become the standard textbook for graduate courses in this area. The Second Edition now brings students to the brink of contemporary research, starting from a background that includes only calculus and elementary linear algebra.The authors are tops in the field of advanced mathematics, including Steve Smale who is a recipient of the Field''s Medal for his work in dynamical systems.* Developed by award-winning researchers and authors* Provides a rigorous yet accessible introduction to differential equations and dynamical systems* Includes bifurcation theory throughout* Contains numerous explorations for students to embark uponNEW IN THIS EDITION* New contemporary material and updated applications* Revisions throughout the text, including simplification...
Fractal differential equations and fractal-time dynamical systems
Abhay Parvate; A D Gangal
2005-03-01
Differential equations and maps are the most frequently studied examples of dynamical systems and may be considered as continuous and discrete time-evolution processes respectively. The processes in which time evolution takes place on Cantor- like fractal subsets of the real line may be termed as fractal-time dynamical systems. Formulation of these systems requires an appropriate framework. A new calculus called -calculus, is a natural calculus on subsets ⊂ R of dimension , 0 < ≤ 1. It involves integral and derivative of order , called -integral and -derivative respectively. The -integral is suitable for integrating functions with fractal support of dimension , while the -derivative enables us to differentiate functions like the Cantor staircase. The functions like the Cantor staircase function occur naturally as solutions of -differential equations. Hence the latter can be used to model fractal-time processes or sublinear dynamical systems. We discuss construction and solutions of some fractal differential equations of the form $$D^{}_{F,t} x = h(x, t),$$ where ℎ is a vector field and $D^{}_{F,t}$ is a fractal differential operator of order in time . We also consider some equations of the form $$D^{}_{F,t} W(x, t) = L[W(x, t)],$$ where is an ordinary differential operator in the real variable , and $(t, x) F × \\mathbf{R}^{n}$ where is a Cantor-like set of dimension . Further, we discuss a method of finding solutions to -differential equations: They can be mapped to ordinary differential equations, and the solutions of the latter can be transformed back to get those of the former. This is illustrated with a couple of examples.
Electrical Property Characterization of Neural Stem Cells in Differentiation.
Yang Zhao
Full Text Available Electrical property characterization of stem cells could be utilized as a potential label-free biophysical approach to evaluate the differentiation process. However, there has been a lack of technology or tools that can quantify the intrinsic cellular electrical markers (e.g., specific membrane capacitance (Cspecific membrane and cytoplasm conductivity (σcytoplasm for a large amount of stem cells or differentiated cells. In this paper, a microfluidic platform enabling the high-throughput quantification of Cspecific membrane and σcytoplasm from hundreds of single neural stem cells undergoing differentiation was developed to explore the feasibility to characterize the neural stem cell differentiation process without biochemical staining. Experimental quantification using biochemical markers (e.g., Nestin, Tubulin and GFAP of neural stem cells confirmed the initiation of the differentiation process featured with gradual loss in cellular stemness and increased cell markers for neurons and glial cells. The recorded electrical properties of neural stem cells undergoing differentiation showed distinctive and unique patterns: 1 in the suspension culture before inducing differentiation, a large distribution and difference in σcytoplasm among individual neural stem cells was noticed, which indicated heterogeneity that may result from the nature of suspension culture of neurospheres; and 2 during the differentiation in adhering monolayer culture, significant changes and a large difference in Cspecific membrane were located indicating different expressions of membrane proteins during the differentiation process, and a small distribution difference in σcytoplasm was less significant that indicated the relatively consistent properties of cytoplasm during the culture. In summary, significant differences in Cspecific membrane and σcytoplasm were observed during the neural stem cell differentiation process, which may potentially be used as label
Dynamic Properties of Impulse Measuring Systems
Pedersen, A.; Lausen, P.
1971-01-01
After some basic considerations the dynamic properties of the measuring system are subjected to a general examination based on a number of responses, characteristic of the system. It is demonstrated that an impulse circuit has an internal impedance different from zero, for which reason the intera......After some basic considerations the dynamic properties of the measuring system are subjected to a general examination based on a number of responses, characteristic of the system. It is demonstrated that an impulse circuit has an internal impedance different from zero, for which reason...
Validation of dynamic risk stratification in pediatric differentiated thyroid cancer.
Sohn, Seo Young; Kim, Young Nam; Kim, Hye In; Kim, Tae Hyuk; Kim, Sun Wook; Chung, Jae Hoon
2017-08-18
There has been increasing interest in a risk-adopted management strategy known as dynamic risk stratification following the revised American Thyroid Association guidelines for differentiated thyroid cancer. We aimed to evaluate the usefulness of dynamic risk stratification for predicting structural disease in pediatric differentiated thyroid cancer patients. We retrospectively reviewed 130 pediatric differentiated thyroid cancer patients (≤19 years) who were treated between 1996 and 2015 at Samsung Medical Center. Patients were stratified according to three American Thyroid Association initial risk group (low, intermediate, or high risk) and four dynamic risk stratification group (excellent, indeterminate, biochemical incomplete, or structural incomplete). Based on dynamic risk stratification strategy, structural disease was identified 3.9% in the excellent group, 9.7% in the indeterminate group, 76.9% in the biochemical incomplete group, and 100% in the structural incomplete group. The hazard ratios of the structural disease were 18.10 (P < 0.001) in the biochemical incomplete group, and 19.583 (P < 0.001) in the structural incomplete group compared to the excellent group. The prevalence of structural disease also increased as American Thyroid Association initial risk classification increased (5.9% in the low-risk group, 13.6% in the intermediate-risk group, and 45% in the high-risk group). The hazard ratios of structural disease in the high-risk group was 10.296 (P < 0.001) in compared to the low-risk group. Dynamic risk stratification based on patient responses to initial therapy was able to effectively predict the risk of structural disease in a pediatric population, and as a follow-up strategy, may work as well in pediatric differentiated thyroid cancer patients as it does in adult differentiated thyroid cancer patients.
Dynamics of five-bar COBOT using differential mechanism
ZHANG Li-xun; LU Dun-min; WANG Lan; SHEN Jin-hua; BERNHARD R.
2003-01-01
COBOT is a new kind of collaborative robot , which can work with people in a shared space. In this paper a new kind of CVT using differential mechanism is introduced, which is major parts of five-bar COBOT and based the feature of nonhlonnmic constraint. The dynamic model of differential mechanism and five-bar architecture COBOT is founded. There are two kinds of coupled mode of two CVT:serial and parallel. In this paper, we present the dynamic model of serial and parallel COBOT take five-bar COBOT as research object. From the dynamic analysis foregoing, both serial and parallel COBOT model are have the feature of nonholonomic constraint. The ending track and moving state are controlled by the force of control motor and operator. The control motor can not control the movement and ending track of COBOT without the cooperation of operator.
Dynamic properties of ultraviolet-exposed polyurea
Youssef, George; Whitten, Ian
2016-11-01
Polyurea is used in military and civilian applications, where exposure to the sun in long durations is imminent. Extended exposure to ultraviolet radiation from the sun can deteriorate its mechanical performance to suboptimal levels. This study reports on the dynamic mechanical properties of polyurea as a function of ultraviolet radiation exposure duration. Six sets of samples were continuously exposed to ultraviolet radiation for different durations up to 18 weeks. Control samples were also tested that did not receive ultraviolet exposure. The dynamic properties were measured using a dynamic mechanical analyzer. Exposed samples exhibited significant color changes from transparent yellow to opaque tan after 18 weeks of exposure. Changes of color were observed as early as 3 weeks of exposure. The dynamic properties showed an initial increase in the dynamic modulus after 3 weeks of exposure, with no further significant change in the stiffness thereafter. The ultraviolet exposure had a significant impact at relatively short loading times or low temperature, for example, up to 6 decades of time. As loading time increases or polyurea operates at high temperature, the effect of ultraviolet exposure and temperature on the performance become highly coupled.
Dynamical topology and statistical properties of spatiotemporal chaos.
Zhuang, Quntao; Gao, Xun; Ouyang, Qi; Wang, Hongli
2012-12-01
For spatiotemporal chaos described by partial differential equations, there are generally locations where the dynamical variable achieves its local extremum or where the time partial derivative of the variable vanishes instantaneously. To a large extent, the location and movement of these topologically special points determine the qualitative structure of the disordered states. We analyze numerically statistical properties of the topologically special points in one-dimensional spatiotemporal chaos. The probability distribution functions for the number of point, the lifespan, and the distance covered during their lifetime are obtained from numerical simulations. Mathematically, we establish a probabilistic model to describe the dynamics of these topologically special points. In spite of the different definitions in different spatiotemporal chaos, the dynamics of these special points can be described in a uniform approach.
Sorting cells by their dynamical properties
Henry, Ewan; Holm, Stefan H.; Zhang, Zunmin; Beech, Jason P.; Tegenfeldt, Jonas O.; Fedosov, Dmitry A.; Gompper, Gerhard
2016-10-01
Recent advances in cell sorting aim at the development of novel methods that are sensitive to various mechanical properties of cells. Microfluidic technologies have a great potential for cell sorting; however, the design of many micro-devices is based on theories developed for rigid spherical particles with size as a separation parameter. Clearly, most bioparticles are non-spherical and deformable and therefore exhibit a much more intricate behavior in fluid flow than rigid spheres. Here, we demonstrate the use of cells’ mechanical and dynamical properties as biomarkers for separation by employing a combination of mesoscale hydrodynamic simulations and microfluidic experiments. The dynamic behavior of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated for different device geometries and viscosity contrasts between the intra-cellular fluid and suspending medium. We find that the viscosity contrast and associated cell dynamics clearly determine the RBC trajectory through a DLD device. Simulation results compare well to experiments and provide new insights into the physical mechanisms which govern the sorting of non-spherical and deformable cells in DLD devices. Finally, we discuss the implications of cell dynamics for sorting schemes based on properties other than cell size, such as mechanics and morphology.
Hydrothermal scheduling via extended differential dynamic programming and mixed coordination
Tang, J. [Alfred Univ., NY (United States). Div. of Electrical Engineering; Luh, P.B. [Univ. of Connecticut, Storrs, CT (United States). Dept. of Electrical and Systems Engineering
1995-11-01
This paper addresses short-term scheduling of hydrothermal systems by using extended differential dynamic programming and mixed coordination. The problem is first decomposed into a thermal subproblem and a hydro subproblem by relaxing the supply-demand constraints. The thermal subproblem is solved analytically. The hydro subproblem is further decomposed into a set of smaller problems that can be solved in parallel. Extended differential dynamic programming and mixed coordination are used to solve the hydro subproblem. Two problems are tested and the results show that the new approach performs well under a simulated parallel processing environment, and high speedup is obtained. The method is then extended to handle unpredictable changes in natural inflow by utilizing the variational feedback nature of the control strategy. A quick estimate on the impact of an unpredictable change on total cost is also obtained. Numerical results show that estimates are accurate, and unpredictable change in natural inflow can be quickly and effectively handled.
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states
Rossi Simona
2010-06-01
Full Text Available Abstract Background The differentiation process, proceeding from stem cells towards the different committed cell types, can be considered as a trajectory towards an attractor of a dynamical process. This view, taking into consideration the transcriptome and miRNome dynamics considered as a whole, instead of looking at few 'master genes' driving the system, offers a novel perspective on this phenomenon. We investigated the 'differentiation trajectories' of the hematopoietic system considering a genome-wide scenario. Results We developed serum-free liquid suspension unilineage cultures of cord blood (CB CD34+ hematopoietic progenitor cells through erythroid (E, megakaryocytic (MK, granulocytic (G and monocytic (Mo pathways. These cultures recapitulate physiological hematopoiesis, allowing the analysis of almost pure unilineage precursors starting from initial differentiation of HPCs until terminal maturation. By analyzing the expression profile of protein coding genes and microRNAs in unilineage CB E, MK, G and Mo cultures, at sequential stages of differentiation and maturation, we observed a coordinated, fully interconnected and scalable character of cell population behaviour in both transcriptome and miRNome spaces reminiscent of an attractor-like dynamics. MiRNome and transcriptome space differed for a still not terminally committed behaviour of microRNAs. Conclusions Consistent with their roles, the transcriptome system can be considered as the state space of a cell population, while the continuously evolving miRNA space corresponds to the tuning system necessary to reach the attractor. The behaviour of miRNA machinery could be of great relevance not only for the promise of reversing the differentiated state but even for tumor biology.
Dynamical properties of the Rabi model
Hu, Binglu; Zhou, Huili; Chen, Shujie; Xianlong, Gao; Wang, Kelin
2017-02-01
We study the dynamical properties of the quantum Rabi model using a systematic expansion method. Based on the observation that the parity symmetry of the Rabi model is kept during evolution of the states, we decompose the initial state and the time-dependent one into positive and negative parity parts expanded by superposition of the coherent states. The evolutions of the corresponding positive and the negative parities are obtained, in which the expansion coefficients in the dynamical equations are known from the derived recurrence relation.
The Electrical and Dynamical Properties of Biomembranes
Mosgaard, Lars Dalskov
of a more general treatment. This purely thermodynamical treatment only describes the equilibrium properties of the membrane, however biological processes are of course dynamical in nature. A clear understanding of the dynamical behavior of lipid membranes is therefore essential when we aim at unraveling...... electrophysiological methods such as \\jump experiments" and impedance spectroscopy performed on lipid membranes. By doing so we observe that a number of non-linear phenomena previously thought to be associated with the presence of proteins embedded in the membrane can just as well be produced by a 'pure' lipid...
Lectures on the theory of group properties of differential equations
Ovsyannikov, LV
2013-01-01
These lecturers provide a clear introduction to Lie group methods for determining and using symmetries of differential equations, a variety of their applications in gas dynamics and other nonlinear models as well as the author's remarkable contribution to this classical subject. It contains material that is useful for students and teachers but cannot be found in modern texts. For example, the theory of partially invariant solutions developed by Ovsyannikov provides a powerful tool for solving systems of nonlinear differential equations and investigating complicated mathematical models. Readers
Multifractal properties of ball milling dynamics
Budroni, M. A., E-mail: mabudroni@uniss.it; Pilosu, V.; Rustici, M. [Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, Sassari 07100 (Italy); Delogu, F. [Dipartimento di Ingegneria Meccanica, Chimica, e dei Materiali, Università degli Studi di Cagliari, via Marengo 2, Cagliari 09123 (Italy)
2014-06-15
This work focuses on the dynamics of a ball inside the reactor of a ball mill. We show that the distribution of collisions at the reactor walls exhibits multifractal properties in a wide region of the parameter space defining the geometrical characteristics of the reactor and the collision elasticity. This feature points to the presence of restricted self-organized zones of the reactor walls where the ball preferentially collides and the mechanical energy is mainly dissipated.
Multifractal properties of ball milling dynamics
Budroni, M. A., E-mail: mabudroni@uniss.it; Pilosu, V.; Rustici, M. [Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, Sassari 07100 (Italy); Delogu, F. [Dipartimento di Ingegneria Meccanica, Chimica, e dei Materiali, Università degli Studi di Cagliari, via Marengo 2, Cagliari 09123 (Italy)
2014-06-15
This work focuses on the dynamics of a ball inside the reactor of a ball mill. We show that the distribution of collisions at the reactor walls exhibits multifractal properties in a wide region of the parameter space defining the geometrical characteristics of the reactor and the collision elasticity. This feature points to the presence of restricted self-organized zones of the reactor walls where the ball preferentially collides and the mechanical energy is mainly dissipated.
Kim, Yung Hae; Larsen, Hjalte List; Rué, Paul
2015-01-01
Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine......, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ductal cells. However, the dynamics of individual progenitors balancing self-renewal and lineage-specific differentiation has never been described. Using three-dimensional live imaging and in vivo...... differentiation process is consistent with a simple model of cell cycle-dependent stochastic priming of progenitors to endocrine fate. The findings provide insights to define control parameters to optimize the generation of β-cells in vitro....
Deterministic Differential Properties of the Compression Function of BMW
Guo, Jian; Thomsen, Søren Steffen
2011-01-01
In this paper, we give some determinstic differential properties for the compression function of SHA-3 candidate Blue Midnight Wish (tweaked version for round 2). The computational complexity is about 20 compression function calls. This applies to security parameters 0/16, 1/15, and 2/14. The eff....../14. The efficient differentials can be used to find pseudo-preimages of the compression function with marginal gain over brute force. However, none of these attacks threaten the security of the BMW hash functions....
Dynamic Properties of Offshore Wind Turbine Foundations
Damgaard, Mads
and material damping in the soil. Modal properties in terms of natural frequencies and corresponding damping ratios of offshore wind turbines are investigated by full-scale modal testing and simple numerical quasi-static simulations. The analyses show distinctly time-varying inherent modal properties that...... of the soil indicates that the modal properties and cross-wind fatigue loads of offshore wind turbines are strongly affected by the interrelation effects between the foundation and subsoil....... with static springs along the foundation and soil damping applied as modal damping. The methods, however, do not account for the dynamic stiffness due to inertia forces, and a welldefined representation of the dissipation effects in the soil is neglected. This in turn forms the basis of the current thesis...
Dynamic molecular crystals with switchable physical properties.
Sato, Osamu
2016-06-21
The development of molecular materials whose physical properties can be controlled by external stimuli - such as light, electric field, temperature, and pressure - has recently attracted much attention owing to their potential applications in molecular devices. There are a number of ways to alter the physical properties of crystalline materials. These include the modulation of the spin and redox states of the crystal's components, or the incorporation within the crystalline lattice of tunable molecules that exhibit stimuli-induced changes in their molecular structure. A switching behaviour can also be induced by changing the molecular orientation of the crystal's components, even in cases where the overall molecular structure is not affected. Controlling intermolecular interactions within a molecular material is also an effective tool to modulate its physical properties. This Review discusses recent advances in the development of such stimuli-responsive, switchable crystalline compounds - referred to here as dynamic molecular crystals - and suggests how different approaches can serve to prepare functional materials.
Dynamic simulation of flash drums using rigorous physical property calculations
F. M. Gonçalves
2007-06-01
Full Text Available The dynamics of flash drums is simulated using a formulation adequate for phase modeling with equations of state (EOS. The energy and mass balances are written as differential equations for the internal energy and the number of moles of each species. The algebraic equations of the model, solved at each time step, are those of a flash with specified internal energy, volume and mole numbers (UVN flash. A new aspect of our dynamic simulations is the use of direct iterations in phase volumes (instead of pressure for solving the algebraic equations. It was also found that an iterative procedure previously suggested in the literature for UVN flashes becomes unreliable close to phase boundaries and a new alternative is proposed. Another unusual aspect of this work is that the model expressions, including the physical properties and their analytical derivatives, were quickly implemented using computer algebra.
Quantitative Map of Proteome Dynamics during Neuronal Differentiation
Christian K. Frese
2017-02-01
Full Text Available Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth, dendritogenesis, and synapse formation. To systematically profile proteome dynamics throughout neuronal differentiation, we took cultured rat hippocampal neurons at different developmental stages and monitored changes in protein abundance using a combination of stable isotope labeling and high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS. Almost one third of all 4,500 proteins quantified underwent a more than 2-fold expression change during neuronal differentiation, indicating extensive remodeling of the neuron proteome. To highlight the strength of our resource, we studied the neural-cell-adhesion molecule 1 (NCAM1 and found that it stimulates dendritic arbor development by promoting actin filament growth at the dendritic growth cone. We anticipate that our quantitative map of neuronal proteome dynamics is a rich resource for further analyses of the many identified proteins in various neurodevelopmental processes.
A dynamic network in a dynamic population: asymptotic properties
Britton, Tom; Turova, Tatyana
2011-01-01
We derive asymptotic properties for a stochastic dynamic network model in a stochastic dynamic population. In the model, nodes give birth to new nodes until they die, each node being equipped with a social index given at birth. During the life of a node it creates edges to other nodes, nodes with high social index at higher rate, and edges disappear randomly in time. For this model we derive criterion for when a giant connected component exists after the process has evolved for a long period of time, assuming the node population grows to infinity. We also obtain an explicit expression for the degree correlation $\\rho$ (of neighbouring nodes) which shows that $\\rho$ is always positive irrespective of parameter values in one of the two treated submodels, and may be either positive or negative in the other model, depending on the parameters.
Structural properties of scaffolds： Crucial parameterstowards stem cells differentiation
2015-01-01
Tissue engineering is a multidisciplinary field thatapplies the principles of engineering and life-sciencesfor regeneration of damaged tissues. Stem cells haveattracted much interest in tissue engineering as a cellsource due to their ability to proliferate in an undifferentiatedstate for prolonged time and capability ofdifferentiating to different cell types after induction.Scaffolds play an important role in tissue engineeringas a substrate that can mimic the native extracellularmatrix and the properties of scaffolds have been shownto affect the cell behavior such as the cell attachment,proliferation and differentiation. Here, we focus on therecent reports that investigated the various aspectsof scaffolds including the materials used for scaffoldfabrication, surface modification of scaffolds, topographyand mechanical properties of scaffolds towards stemcells differentiation effect. We will present a moredetailed overview on the effect of mechanical propertiesof scaffolds on stem cells fate.
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation
Goode, Debbie K.; Obier, Nadine; Vijayabaskar, M.S.; Lie-A-Ling, Michael; Lilly, Andrew J.; Hannah, Rebecca; Lichtinger, Monika; Batta, Kiran; Florkowska, Magdalena; Patel, Rahima; Challinor, Mairi; Wallace, Kirstie; Gilmour, Jane; Assi, Salam A.; Cauchy, Pierre; Hoogenkamp, Maarten; Westhead, David R.; Lacaud, Georges; Kouskoff, Valerie; Göttgens, Berthold; Bonifer, Constanze
2016-01-01
Summary Metazoan development involves the successive activation and silencing of specific gene expression programs and is driven by tissue-specific transcription factors programming the chromatin landscape. To understand how this process executes an entire developmental pathway, we generated global gene expression, chromatin accessibility, histone modification, and transcription factor binding data from purified embryonic stem cell-derived cells representing six sequential stages of hematopoietic specification and differentiation. Our data reveal the nature of regulatory elements driving differential gene expression and inform how transcription factor binding impacts on promoter activity. We present a dynamic core regulatory network model for hematopoietic specification and demonstrate its utility for the design of reprogramming experiments. Functional studies motivated by our genome-wide data uncovered a stage-specific role for TEAD/YAP factors in mammalian hematopoietic specification. Our study presents a powerful resource for studying hematopoiesis and demonstrates how such data advance our understanding of mammalian development. PMID:26923725
Structural and dynamical properties of complex networks
Ghoshal, Gourab
Recent years have witnessed a substantial amount of interest within the physics community in the properties of networks. Techniques from statistical physics coupled with the widespread availability of computing resources have facilitated studies ranging from large scale empirical analysis of the worldwide web, social networks, biological systems, to the development of theoretical models and tools to explore the various properties of these systems. Following these developments, in this dissertation, we present and solve for a diverse set of new problems, investigating the structural and dynamical properties of both model and real world networks. We start by defining a new metric to measure the stability of network structure to disruptions, and then using a combination of theory and simulation study its properties in detail on artificially generated networks; we then compare our results to a selection of networks from the real world and find good agreement in most cases. In the following chapter, we propose a mathematical model that mimics the structure of popular file-sharing websites such as Flickr and CiteULike and demonstrate that many of its properties can solved exactly in the limit of large network size. The remaining part of the dissertation primarily focuses on the dynamical properties of networks. We first formulate a model of a network that evolves under the addition and deletion of vertices and edges, and solve for the equilibrium degree distribution for a variety of cases of interest. We then consider networks whose structure can be manipulated by adjusting the rules by which vertices enter and leave the network. We focus in particular on degree distributions and show that, with some mild constraints, it is possible by a suitable choice of rules to arrange for the network to have any degree distribution we desire. In addition we define a simple local algorithm by which appropriate rules can be implemented in practice. Finally, we conclude our
Differential geometry and topology with a view to dynamical systems
Burns, Keith
2005-01-01
MANIFOLDSIntroductionReview of topological conceptsSmooth manifoldsSmooth mapsTangent vectors and the tangent bundleTangent vectors as derivationsThe derivative of a smooth mapOrientationImmersions, embeddings and submersionsRegular and critical points and valuesManifolds with boundarySard's theoremTransversalityStabilityExercisesVECTOR FIELDS AND DYNAMICAL SYSTEMSIntroductionVector fieldsSmooth dynamical systemsLie derivative, Lie bracketDiscrete dynamical systemsHyperbolic fixed points and periodic orbitsExercisesRIEMANNIAN METRICSIntroductionRiemannian metricsStandard geometries on surfacesExercisesRIEMANNIAN CONNECTIONS AND GEODESICSIntroductionAffine connectionsRiemannian connectionsGeodesicsThe exponential mapMinimizing properties of geodesicsThe Riemannian distanceExercisesCURVATUREIntroductionThe curvature tensorThe second fundamental formSectional and Ricci curvaturesJacobi fieldsManifolds of constant curvatureConjugate pointsHorizontal and vertical sub-bundlesThe geodesic flowExercisesTENSORS AND DI...
Dynamical properties of unconventional magnetic systems
Helgesen, G. [ed.
1997-05-01
The Advanced Study Institute addressed the current experimental and theoretical knowledge of the dynamical properties of unconventional magnetic systems including low-dimensional and mesoscopic magnetism, unconventional ground state, quantum magnets and soft matter. The main approach in this Advanced Study Institute was to obtain basic understanding of co-operative phenomena, fluctuations and excitations in the wide range unconventional magnetic systems now being fabricated or envisioned. The report contains abstracts for lectures, invited seminars and posters, together with a list of the 95 participants from 24 countries with e-mail addresses
Dynamics of Chloroplast Translation during Chloroplast Differentiation in Maize.
Prakitchai Chotewutmontri
2016-07-01
Full Text Available Chloroplast genomes in land plants contain approximately 100 genes, the majority of which reside in polycistronic transcription units derived from cyanobacterial operons. The expression of chloroplast genes is integrated into developmental programs underlying the differentiation of photosynthetic cells from non-photosynthetic progenitors. In C4 plants, the partitioning of photosynthesis between two cell types, bundle sheath and mesophyll, adds an additional layer of complexity. We used ribosome profiling and RNA-seq to generate a comprehensive description of chloroplast gene expression at four stages of chloroplast differentiation, as displayed along the maize seedling leaf blade. The rate of protein output of most genes increases early in development and declines once the photosynthetic apparatus is mature. The developmental dynamics of protein output fall into several patterns. Programmed changes in mRNA abundance make a strong contribution to the developmental shifts in protein output, but output is further adjusted by changes in translational efficiency. RNAs with prioritized translation early in development are largely involved in chloroplast gene expression, whereas those with prioritized translation in photosynthetic tissues are generally involved in photosynthesis. Differential gene expression in bundle sheath and mesophyll chloroplasts results primarily from differences in mRNA abundance, but differences in translational efficiency amplify mRNA-level effects in some instances. In most cases, rates of protein output approximate steady-state protein stoichiometries, implying a limited role for proteolysis in eliminating unassembled or damaged proteins under non-stress conditions. Tuned protein output results from gene-specific trade-offs between translational efficiency and mRNA abundance, both of which span a large dynamic range. Analysis of ribosome footprints at sites of RNA editing showed that the chloroplast translation machinery
Dynamics of Chloroplast Translation during Chloroplast Differentiation in Maize.
Chotewutmontri, Prakitchai; Barkan, Alice
2016-07-01
Chloroplast genomes in land plants contain approximately 100 genes, the majority of which reside in polycistronic transcription units derived from cyanobacterial operons. The expression of chloroplast genes is integrated into developmental programs underlying the differentiation of photosynthetic cells from non-photosynthetic progenitors. In C4 plants, the partitioning of photosynthesis between two cell types, bundle sheath and mesophyll, adds an additional layer of complexity. We used ribosome profiling and RNA-seq to generate a comprehensive description of chloroplast gene expression at four stages of chloroplast differentiation, as displayed along the maize seedling leaf blade. The rate of protein output of most genes increases early in development and declines once the photosynthetic apparatus is mature. The developmental dynamics of protein output fall into several patterns. Programmed changes in mRNA abundance make a strong contribution to the developmental shifts in protein output, but output is further adjusted by changes in translational efficiency. RNAs with prioritized translation early in development are largely involved in chloroplast gene expression, whereas those with prioritized translation in photosynthetic tissues are generally involved in photosynthesis. Differential gene expression in bundle sheath and mesophyll chloroplasts results primarily from differences in mRNA abundance, but differences in translational efficiency amplify mRNA-level effects in some instances. In most cases, rates of protein output approximate steady-state protein stoichiometries, implying a limited role for proteolysis in eliminating unassembled or damaged proteins under non-stress conditions. Tuned protein output results from gene-specific trade-offs between translational efficiency and mRNA abundance, both of which span a large dynamic range. Analysis of ribosome footprints at sites of RNA editing showed that the chloroplast translation machinery does not generally
PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation.
Trujillo, Sara; Lizundia, Erlantz; Vilas, José Luis; Salmeron-Sanchez, Manuel
2016-08-01
This work investigates the effect of the sequential availability of ZnO nanoparticles, (nanorods of ∼40nm) loaded within a degradable poly(lactic acid) (PLLA) matrix, in cell differentiation. The system constitutes a dynamic surface, in which nanoparticles are exposed as the polymer matrix degrades. ZnO nanoparticles were loaded into PLLA and the system was measured at different time points to characterise the time evolution of the physicochemical properties, including wettability and thermal properties. The micro and nanostructure were also investigated using AFM, SEM and TEM images. Cellular experiments with C2C12 myoblasts show that cell differentiation was significantly enhanced on ZnO nanoparticles-loaded PLLA, as the polymer degrades and the availability of nanoparticles become more apparent, whereas the release of zinc within the culture medium was negligible. Our results suggest PLLA/ZnO nanocomposites can be used as a dynamic system where nanoparticles are exposed during degradation, activating the material surface and driving cell differentiation.
Dynamic HMM Model with Estimated Dynamic Property in Continuous Mandarin Speech Recognition
CHENFeili; ZHUJie
2003-01-01
A new dynamic HMM (hiddem Markov model) has been introduced in this paper, which describes the relationship between dynamic property and feature of space. The method to estimate the dynamic property is discussed in this paper, which makes the dynamic HMMmuch more practical in real time speech recognition. Ex-periment on large vocabulary continuous Mandarin speech recognition task has shown that the dynamic HMM model can achieve about 10% of error reduction both for tonal and toneless syllable. Estimated dynamic property can achieve nearly same (even better) performance than using extracted dynamic property.
Relation between observability and differential embeddings for nonlinear dynamics
Letellier, Christophe; Aguirre, Luis A.; Maquet, Jean
2005-06-01
In the analysis of a scalar time series, which lies on an m -dimensional object, a great number of techniques will start by embedding such a time series in a d -dimensional space, with d>m . Therefore there is a coordinate transformation Φs from the original phase space to the embedded one. The embedding space depends on the observable s(t) . In theory, the main results reached are valid regardless of s(t) . In a number of practical situations, however, the choice of the observable does influence our ability to extract dynamical information from the embedded attractor. This may arise in problems in nonlinear dynamics such as model building, control and synchronization. To some degree, ease of success will depend on the choice of the observable simply because it is related to the observability of the dynamics. In this paper the observability matrix for nonlinear systems, which uses Lie derivatives, is revisited. It is shown that such a matrix can be interpreted as the Jacobian matrix of Φs —the map between the original phase space and the differential embedding induced by the observable—thus establishing a link between observability and embedding theory.
Multiscale functions, scale dynamics, and applications to partial differential equations
Cresson, Jacky; Pierret, Frédéric
2016-05-01
Modeling phenomena from experimental data always begins with a choice of hypothesis on the observed dynamics such as determinism, randomness, and differentiability. Depending on these choices, different behaviors can be observed. The natural question associated to the modeling problem is the following: "With a finite set of data concerning a phenomenon, can we recover its underlying nature? From this problem, we introduce in this paper the definition of multi-scale functions, scale calculus, and scale dynamics based on the time scale calculus [see Bohner, M. and Peterson, A., Dynamic Equations on Time Scales: An Introduction with Applications (Springer Science & Business Media, 2001)] which is used to introduce the notion of scale equations. These definitions will be illustrated on the multi-scale Okamoto's functions. Scale equations are analysed using scale regimes and the notion of asymptotic model for a scale equation under a particular scale regime. The introduced formalism explains why a single scale equation can produce distinct continuous models even if the equation is scale invariant. Typical examples of such equations are given by the scale Euler-Lagrange equation. We illustrate our results using the scale Newton's equation which gives rise to a non-linear diffusion equation or a non-linear Schrödinger equation as asymptotic continuous models depending on the particular fractional scale regime which is considered.
Dynamic properties of interfaces in soft matter: Experiments and theory
Sagis, L.M.C.
2011-01-01
The dynamic properties of interfaces often play a crucial role in the macroscopic dynamics of multiphase soft condensed matter systems. These properties affect the dynamics of emulsions, of dispersions of vesicles, of biological fluids, of coatings, of free surface flows, of immiscible polymer
Dynamical Properties of Internal Shocks Revisited
Pe'er, Asaf; Casella, Piergiorgio
2016-01-01
Internal shocks between propagating plasma shells, originally ejected at different times with different velocities are believed to play a major role in dissipating the kinetic energy, thereby explaining the observed lightcurve and spectra in a large range of transient objects. Even if initially the colliding plasmas are cold, following the first collision the plasma shells are substantially heated, implying that in a scenario of multiple collisions, most collisions take place between plasmas of non-zero temperatures. Here, we calculate the dynamical properties of plasmas resulting from collision between arbitrarily hot plasma shells, moving at arbitrary speeds. We provide simple analytical expressions valid for both the ultra-relativistic and Newtonian velocities, for both hot and cold plasmas. We derive the minimum criteria required for the formation of the two-shock wave system, and show that in the relativistic limit, the minimum Lorentz factor is proportional to the square root of the ratio of the initial...
Extending Differential Fault Analysis to Dynamic S-Box Advanced Encryption Standard Implementations
2014-09-18
EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX ADVANCED ENCRYPTION STANDARD IMPLEMENTATIONS THESIS Bradley M. Flamm, Civilian AFIT-ENG-T-14-S...Government and is not subject to copyright protection in the United States. AFIT-ENG-T-14-S-08 EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX...RELEASE; DISTRIBUTION UNLIMITED AFIT-ENG-T-14-S-08 EXTENDING DIFFERENTIAL FAULT ANALYSIS TO DYNAMIC S-BOX ADVANCED ENCRYPTION STANDARD IMPLEMENTATIONS
Dynamic viscoelastic properties of polyvinyl chloride with physical aging
Tian, Fang; Luo, Yingshe; Yin, Shuiping; Wang, Hong; Cao, Chun
2015-11-01
The experimental research of dynamic viscoelastic properties of polyvinyl chloride was conducted by the dynamic mechanical analysis method in this paper. And the fitting equation of dynamic modulus of polymers has been presented. Based on the time-aging time equivalent principle, horizontal shift factor and vertical shift factor of aging time are carried out, which proposes a novel method for the research on time-aging time equivalent analysis of dynamic mechanical properties of polymers during physical aging.
Stability properties of autonomous homogeneous polynomial differential systems
Samardzija, Nikola
A geometrical approach is used to derive a generalized characteristic value problem for dynamic systems described by homogeneous polynomials. It is shown that a nonlinear homogeneous polynomial system possesses eigenvectors and eigenvalues, quantities normally associated with a linear system. These quantities are then employed in studying stability properties. The necessary and sufficient conditions for all forms of stabilities characteristic of a two-dimensional system are provided. This result, together with the classical theorem of Frommer, completes a stability analysis for a two-dimensional homogeneous polynomial system.
HU Yu-jia; ZHU Yuan-yuan; CHENG Chang-jun
2008-01-01
A nonlinear mathematical model for the analysis of large deformation of frame structures with discontinuity conditions and initial displacements,subject to dynamic loads is formulated with arc-coordinates.The differential quadrature element method (DQEM)is then applied to discretize the nonlinear mathematical model in the spatial domain.An effective method is presented to deal with discontinuity conditions of multivariables in the application of DQEM.A set of DQEM discretization equations are obtained,which are a set of nonlinear differential-algebraic equations with singularity in the time domain.This paper also presents a method to solve nonlinear differential-algebra equations.As application,static and dynamical analyses of large deformation of frames and combined frame structures,subjected to concentrated and distributed forces,are presented.The obtained results are compared with those in the literatares.Numerical results show that the proposed method is general,and effective in dealing with discontinuity conditions of multi-variables and solving difierential-algebraic equations.It requires only a small number of nodes and has low computation complexity with high precision and a good convergence property.
Differential surface properties of commercial crystalline telmisartan samples.
Laad, Preksha; Shete, Ganesh; Modi, Sameer R; Bansal, Arvind Kumar
2013-05-13
The aim of the present study was to investigate differences in surface chemistry of commercially available telmisartan (TMS) samples in Indian market and to correlate them to the surface molecular environment. Comprehensive characterization of material properties of four TMS samples from different sources showed that all samples exhibited same polymorphic form, but different particle shape, particle size distribution, surface energetics and surface chemistry. Wettability and surface free energy were determined using sessile drop contact angle technique. TMS samples exhibited significant variations in their wetting behavior. The role of crystal shape, particle size distribution, surface energetics and surface chemistry in controlling TMS powder wettability was collectively explored by contact angle experiments. Evaluation of work of adhesion (Wa), immersion (Wi) and spreading (Ws) indicated that samples had differential wetting behavior. The surface chemistry was elucidated by X-ray photoelectron spectroscopy (XPS). The surface polarity index was determined by XPS and expressed as (oxygen+nitrogen)-to-(carbon) atomic concentration ratio. It was found to be different for all four TMS samples. Crystal morphology of TMS polymorph A was predicted using Bravais-Friedel Donnay-Harker (BFDH) method. Molecular lipophilic surface potential (MLSP) data for TMS showed the varied surface lipophilic environment throughout the molecule. Hence it can be concluded that the differential abundance of surface elements play an important role in controlling the biopharmaceutical performance of TMS powder samples.
Differential area profiles: decomposition properties and efficient computation.
Ouzounis, Georgios K; Pesaresi, Martino; Soille, Pierre
2012-08-01
Differential area profiles (DAPs) are point-based multiscale descriptors used in pattern analysis and image segmentation. They are defined through sets of size-based connected morphological filters that constitute a joint area opening top-hat and area closing bottom-hat scale-space of the input image. The work presented in this paper explores the properties of this image decomposition through sets of area zones. An area zone defines a single plane of the DAP vector field and contains all the peak components of the input image, whose size is between the zone's attribute extrema. Area zones can be computed efficiently from hierarchical image representation structures, in a way similar to regular attribute filters. Operations on the DAP vector field can then be computed without the need for exporting it first, and an example with the leveling-like convex/concave segmentation scheme is given. This is referred to as the one-pass method and it is demonstrated on the Max-Tree structure. Its computational performance is tested and compared against conventional means for computing differential profiles, relying on iterative application of area openings and closings. Applications making use of the area zone decomposition are demonstrated in problems related to remote sensing and medical image analysis.
Dynamic properties of bacterial pili measured by optical tweezers
Fallman, Erik G.; Andersson, Magnus J.; Schedin, Staffan S.; Jass, Jana; Uhlin, Bernt Eric; Axner, Ove
2004-10-01
The ability of uropathogenic Escherichia coli (UPEC) to cause urinary tract infections is dependent on their ability to colonize the uroepithelium. Infecting bacteria ascend the urethra to the bladder and then kidneys by attaching to the uroepithelial cells via the differential expression of adhesins. P pili are associated with pyelonephritis, the more severe infection of the kidneys. In order to find means to treat pyelonephritis, it is therefore of interest to investigate the properties P pili. The mechanical behavior of individual P pili of uropathogenic Escherichia coli has recently been investigated using optical tweezers. P pili, whose main part constitutes the PapA rod, composed of ~1000 PapA subunits in a helical arrangement, are distributed over the bacterial surface and mediate adhesion to host cells. We have earlier studied P pili regarding its stretching/elongation properties where we have found and characterized three different elongation regions, of which one constitute an unfolding of the quaternary (helical) structure of the PapA rod. It was shown that this unfolding takes place at an elongation independent force of 27 +/- 2 pN. We have also recently performed studies on its folding properties and shown that the unfolding/folding of the PapA rod is completely reversible. Here we present a study of the dynamical properties of the PapA rod. We show, among other things, that the unfolding force increases and that the folding force decreases with the speed of unfolding and folding respectively. Moreover, the PapA rod can be folded-unfolded a significant number of times without loosing its characteristics, a phenomenon that is believed to be important for the bacterium to keep close contact to the host tissue and consequently helps the bacterium to colonize the host tissue.
Sharma, Neelesh; Kim, Jeong Hyun; Sodhi, Simrinder Singh; Luong, Do Huynh; Kim, Sung-Woo; Oh, Sung Jong; Jeong, Dong Kee
2015-01-01
The "stem cells" are commonly defined as "cells capable of self-renewal through replication and differentiating into specific lineages". The mammary gland contains functional stem/progenitor cells. The current study was planned with the objectives to study the differentiation dynamics of Korean Holstein mammary epithelial stem cells (KHMESCs) under the optimum culture conditions. Lineage negative KHMESCs isolated from mammary tissue of lactating cows have shown the typical differentiation dynamics with formation of lobulo-alveolar structures in in vitro culture. This suggests the existence of bipotential mammary epithelial stem cells in the mammary gland. The strong mRNA expression of pluripotency factors indicates stemness, whereas expression of milk protein genes and epithelial cell-specific gene indicate their differentiation capabilities. Further, immunostaining results have shown the differentiation capabilities of KHMESCs into both luminal and basal lineages under the extracellular matrix (ECM, matrigel) free environment. However, under matrigel, the differentiation process was comparatively higher than without matrigel. Immunostaining results also suggested that differentiated cells could secrete milk proteins such as β-casein. To our knowledge, these data represent the first report on the differentiation dynamics and establishment of mammary epithelial stem cells from Korean Holstein with typical stemness properties. It was observed that isolated KHMESCs had normal morphology, growth pattern, differentiation ability, cytogenetic and secretory activity even without ECM. Therefore, it is concluded that established KHMESCs could be used for further studies on Korean Holstein dairy cows related to lactation studies, as non-GMO animal bioreactors and stem cell-based management of bovine mastitis including post-mastitis damage.
Thermodynamical and dynamical properties of charged BTZ black holes
Tang, Zi-Yu; Wang, Bin [Shanghai Jiao Tong University, Department of Physics and Astronomy, Center for Astronomy and Astrophysics, Shanghai (China); Zhang, Cheng-Yong [Peking University, Center for High-Energy Physics, Beijing (China); Kord Zangeneh, Mahdi [Shanghai Jiao Tong University, Department of Physics and Astronomy, Center for Astronomy and Astrophysics, Shanghai (China); Shahid Chamran University of Ahvaz, Physics Department, Faculty of Science, Ahvaz (Iran, Islamic Republic of); Research Institute for Astronomy and Astrophysics of Maragha (RIAAM)-Maragha, P. O. Box: 55134-441, Maragha (Iran, Islamic Republic of); Shiraz University, Physics Department and Biruni Observatory, College of Sciences, Shiraz (Iran, Islamic Republic of); Saavedra, Joel [Pontificia Universidad Catolica de Valparaiso, Instituto de Fisica, Valparaiso (Chile)
2017-06-15
We investigate the spacetime properties of BTZ black holes in the presence of the Maxwell field and Born-Infeld field and find rich properties in the spacetime structures when the model parameters are varied. Employing Landau-Lifshitz theory, we examine the thermodynamical phase transition in the charged BTZ black holes. We further study the dynamical perturbation in the background of the charged BTZ black holes and find different properties in the dynamics when the thermodynamical phase transition occurs. (orig.)
Mahesh Wickramasinghe
Full Text Available Dynamical processes in many engineered and living systems take place on complex networks of discrete dynamical units. We present laboratory experiments with a networked chemical system of nickel electrodissolution in which synchronization patterns are recorded in systems with smooth periodic, relaxation periodic, and chaotic oscillators organized in networks composed of up to twenty dynamical units and 140 connections. The reaction system formed domains of synchronization patterns that are strongly affected by the architecture of the network. Spatially organized partial synchronization could be observed either due to densely connected network nodes or through the 'chimera' symmetry breaking mechanism. Relaxation periodic and chaotic oscillators formed structures by dynamical differentiation. We have identified effects of network structure on pattern selection (through permutation symmetry and coupling directness and on formation of hierarchical and 'fuzzy' clusters. With chaotic oscillators we provide experimental evidence that critical coupling strengths at which transition to identical synchronization occurs can be interpreted by experiments with a pair of oscillators and analysis of the eigenvalues of the Laplacian connectivity matrix. The experiments thus provide an insight into the extent of the impact of the architecture of a network on self-organized synchronization patterns.
Frequency-dependent dynamic effective properties of porous materials
Peijun Wei; Zhuping Huang
2005-01-01
The frequency-dependent dynamic effective properties (phase velocity, attenuation and elastic modulus) of porous materials are studied numerically. The coherent plane longitudinal and shear wave equations, which are obtained by averaging on the multiple scattering fields, are used to evaluate the frequency-dependent dynamic effective properties of a porous material. It is found that the prediction of the dynamic effective properties includes the size effects of voids which are not included in most prediction of the traditional static effective properties. The prediction of the dynamic effective elastic modulus at a relatively low frequency range is compared with that of the traditional static effective elastic modulus, and the dynamic effective elastic modulus is found to be very close to the Hashin-Shtrikman upper bound.
ANALYSIS OF REGIONAL ECONOMY GROWTH WITH THE THEORY OF DIFFERENTIAL SYSTEM DYNAMICS
XU Jiuping; LIU Jicheng
2003-01-01
In order to describe the interrelation forces among different regions during the economic growth, this paper introduces and analyzes the dynamical system model with the theory of differential systems dynamics. A practical example based on a simplified model is given to analyze the dynamical process of Sichuan economy growth.
Dynamic Properties of Viscoelastic Open Shallow Shells%粘弹性开敞浅壳的动力学性质
无
2000-01-01
On the basis of the Kármán-Donnell theory of thin shells with large deflections and the Boltzmann laws for linear viscoelastic materials, the mathematical model for viscoelastic open shallow shells was formulated. By using the Galerkin average method, the original integro-partial-differential dynamic system was simplified as a integro-ordinary-differential dynamic system, which can be transformed into a ordinary differential dynamic system by introducing new variables. The dynamical behavior was studied by some classical methods. Dynamical properties, such as, chaos, strange attractor, limit cycle etc., were discovered.
Dynamic damping property of magnetorheological elastomer
李剑锋; 龚兴龙
2008-01-01
Magnetorheological elastomer(MRE) is a new kind of smart materials,its dynamic mechanic performances can be controlled by an applied magnetic field.MRE is usually used as a stiffness-changeable spring in the semi-active vibration absorber.In order to get perfect vibration control effect,low dynamic damping of MRE is need.But the dynamic damping of MRE was not studied deeply in the past.The dynamic damping of MRE was studied and analyzed.The influences of different test conditions including test strain amplitude,test frequency and test magnetic field were deeply studied.MRE sample and pure silicone rubber sample were prepared and tested under different conditions.The test results show that the main source of dynamic damping is the friction between iron particles and rubber matrix.And the friction is mainly influenced by the strain amplitude and test magnetic field.
Certain Ergodic Properties of a Differential System on a Compact Differentiable Manifold
LIAO Shan-tao
2006-01-01
Let Mn be an n-dimensional compact C∞-differentiable manifold,n≥2,and let S be a C1 -differential system on Mn.The system induces a one-parameter C1 transformation group φt(-∞＜t＜∞) over Mn and,thus,naturally induces a one-parameter transformation group of the tangent bundle of Mn.The aim of this paper,in essence,is to study certain ergodic properties of this latter transformation group.Among various results established in the paper,we mention here only the following,which might describe quite well the nature of our study.(A) Let M be the set of regular points in Mn of the differential system S.With respect to a given C∞ Riemannian metric of Mn,we consider the bundle (ζ)# of all (n-2) spheres Qxn-2,x∈M,where Qxn-2 for each x consists of all unit tangent vectors of Mn orthogonal to the trajectory through x.Then,the differential system S gives rise naturally to a one-parameter transformation group Ψt#(-∞＜t＜∞) of (ζ)#.For an l-frame α=(u1,u2,…,ul) of Mn at a point x in M,1 ≥l≥n-1,each ui being in (ζ)#,we shall denote the volume of the parallelotope in the tangent space of Mn at x with edges u1,u2,…,ut by v(α),and let η*α(t)=v(Ψ#t (u1),Ψ#t(u2),…,Ψ#t (ul)).This is a continuous real function of t.Let I*+(α)=-limT→∞1/T∫T0η*α(t)dt,I*-(α)=-limT→-∞1/T∫T0η*α(t)dt.α is said to be positively linearly independent of the mean if I+*(α)＞0.Similarly,α is said to be negatively linearly independent of the mean if I_ *(a)＞0.A point x of M is said to possess positive generic index κ=κ+*(x) if,at x,there is a κ-frame α= (u1,u2,…,Uκ),ui ∈(ζ)#,of Mn having the property of being positively linearly independent in the mean,but at x,every l-frame β=(v1,v2,…,vl),vi ∈(ζ)#,of Mn with l＞κ does not have the same property.Similarly,we define the negative generic index κ_*(x) of x.For a nonempty closed subset F of Mn consisting of regular points of S,invariant under φt(-∞＜t＜∞),let the (positive and
Dynamic Logics of Dynamical Systems
Platzer, André
2012-01-01
We survey dynamic logics for specifying and verifying properties of dynamical systems, including hybrid systems, distributed hybrid systems, and stochastic hybrid systems. A dynamic logic is a first-order modal logic with a pair of parametrized modal operators for each dynamical system to express necessary or possible properties of their transition behavior. Due to their full basis of first-order modal logic operators, dynamic logics can express a rich variety of system properties, including safety, controllability, reactivity, liveness, and quantified parametrized properties, even about relations between multiple dynamical systems. In this survey, we focus on some of the representatives of the family of differential dynamic logics, which share the ability to express properties of dynamical systems having continuous dynamics described by various forms of differential equations. We explain the dynamical system models, dynamic logics of dynamical systems, their semantics, their axiomatizations, and proof calcul...
Dynamic properties of the action potential encoder in an insect mechanosensory neuron.
French, A S
1984-08-01
A variety of sensory receptors show adaptation to dynamic stimuli that can be well characterized as fractional differentiation of the input signal. The cause of this behavior is unknown, but because it can be represented by linear systems theory, it has been assumed to arise during early linear processes of transduction or adaptation, rather than during the nonlinear process of action potential encoding. I measured the action potential encoding properties of an insect mechanoreceptor by direct electrical stimulation of the sensory cell axon and found a dynamic response that is identical to the response given by mechanical stimulation. This indicates that the fractional differentiation is a property of the encoder rather than the transducer.
Analytical properties of a three-compartmental dynamical demographic model
Postnikov, E. B.
2015-07-01
The three-compartmental demographic model by Korotaeyv-Malkov-Khaltourina, connecting population size, economic surplus, and education level, is considered from the point of view of dynamical systems theory. It is shown that there exist two integrals of motion, which enables the system to be reduced to one nonlinear ordinary differential equation. The study of its structure provides analytical criteria for the dominance ranges of the dynamics of Malthus and Kremer. Additionally, the particular ranges of parameters enable the derived general ordinary differential equations to be reduced to the models of Gompertz and Thoularis-Wallace.
PARAMETRIC ANALYSIS OF THE DYNAMIC PROPERTIES OF ...
static and dynamic analysis of structures [2, 3,4]. ... than by the expected complexity of their behavior. This fact has been .... The computational cost of extracting the vibration modes can be reduced by applying one of the condensation.
Jun Shuai
2013-11-01
Full Text Available A new approach using optimization technique for constructing low-dimensional dynamical systems of nonlinear partial differential equations (PDEs is presented. After the spatial basis functions of the nonlinear PDEs are chosen, spatial basis functions expansions combined with weighted residual methods are used for time/space separation and truncation to obtain a high-dimensional dynamical system. Secondly, modes of lower-dimensional dynamical systems are obtained by linear combination from the modes of the high-dimensional dynamical systems (ordinary differential equations of nonlinear PDEs. An error function for matrix of the linear combination coefficients is derived, and a simple algorithm to determine the optimal combination matrix is also introduced. A numerical example shows that the optimal dynamical system can use much smaller number of modes to capture the dynamics of nonlinear partial differential equations.
Dynamic and kinetic properties of Al-Li melts
Kiselev, A. I.
2008-12-01
The dynamic and kinetic properties of Al-Li melts are calculated. The liquid phase of this system is shown to be characterized by three states with different ion distributions and different degrees of electron localization.
Veli B SHAKHMUROV
2008-01-01
The unique continuation theorems for the anisotropic partial differential-operator equations with variable coefficients in Banach-valued Lp-spaces are studied. To obtain the uniform maximal regularity and the Carleman type estimates for parameter depended differential-operator equations, the sufficient conditions are founded. By using these facts, the unique continuation properties are established. In the application part, the unique continuation properties and Carleman estimates for finite or infinite systems of quasielliptic partial differential equations are studied.
Interfacial Properties of an Ionic Liquid by Molecular Dynamics
Heggen, B.; Zhao, W.; Leroy, F.; Dammers, A.T.; Müller-Plathe, F.
2010-01-01
We studied the influence of a liquid-vapor interface on dynamic properties like reorientation and diffusion as well as the surface tension of the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) by molecular dynamics simulations. In the interfacial region, reorientation of
Interfacial Properties of an Ionic Liquid by Molecular Dynamics
Heggen, B.; Zhao, W.; Leroy, F.; Dammers, A.T.; Müller-Plathe, F.
2010-01-01
We studied the influence of a liquid-vapor interface on dynamic properties like reorientation and diffusion as well as the surface tension of the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) by molecular dynamics simulations. In the interfacial region, reorientation of
D. Bahuguna
2005-01-01
Full Text Available We consider a retarded differential equation with applications to population dynamics. We establish the convergence of a finite-dimensional approximations of a unique solution, the existence and uniqueness of which are also proved in the process.
Dynamic Properties of Offshore Wind Turbine Foundations
Damgaard, Mads
with static springs along the foundation and soil damping applied as modal damping. The methods, however, do not account for the dynamic stiffness due to inertia forces, and a welldefined representation of the dissipation effects in the soil is neglected. This in turn forms the basis of the current thesis...... that capture the most important effects of the dynamic wind turbine response. To overcome this, sequential or fully coupled aero-hydro-elastic simulations are often conducted where the soil–structure interaction is incorporated via the principle of an equivalent fixity depth or by a so-called Winkler approach...
Implications of the Hopf algebra properties of noncommutative differential calculi
1996-01-01
We define a noncommutative algebra of four basic objects within a differential calculus on quantum groups: functions, 1-forms, Lie derivatives and inner derivations, as the cross-product algebra associated with Woronowicz's (differential) algebra of functions and forms. This definition properly takes into account the Hopf algebra structure of the Woronowicz calculus. It also provides a direct proof of the Cartan identity.
Implications of the Hopf algebra properties of noncommutative differential calculi
Vladimirov, A.A.
1996-01-01
We define a noncommutative algebra of four basic objects within a differential calculus on quantum groups: functions, 1-forms, Lie derivatives and inner derivations, as the cross-product algebra associated with Woronowicz's (differential) algebra of functions and forms. This definition properly takes into account the Hopf algebra structure of the Woronowicz calculus. It also provides a direct proof of the Cartan identity.
SOME DYNAMICAL PROPERTIES OF QUADRATIC RATIONAL MAPS
YINYONGCHENG
1994-01-01
This paper studies the dynamics of the analytic family z+1/z+b and describes the topology of the parameter space, structural stability and J-stability. The mapping class group of almost all maps of the above family is determined.
Material properties under intensive dynamic loading
Cherne, Frank J; Zhernokletov, Mikhail V; Glushak, B L; Zocher, Marvin A
2007-01-01
Understanding the physical and thermomechanical response of materials subjected to intensive dynamic loading is a challenge of great significance in engineering today. This volume assumes the task of gathering both experimental and diagnostic methods in one place, since not much information has been previously disseminated in the scientific literature.
Group Dynamics and Individual Roles: A Differentiated Approach to Social-Emotional Learning
Dugas, Daryl
2017-01-01
Differentiated instruction is a set of strategies to help teachers meet each child where he or she is in order to improve students' engagement, lead them to do their best work, and maximize their success. This article describes a differentiated classroom management approach based in group dynamics which focuses on the development of group norms…
Group Dynamics and Individual Roles: A Differentiated Approach to Social-Emotional Learning
Dugas, Daryl
2017-01-01
Differentiated instruction is a set of strategies to help teachers meet each child where he or she is in order to improve students' engagement, lead them to do their best work, and maximize their success. This article describes a differentiated classroom management approach based in group dynamics which focuses on the development of group norms…
Barbu, Viorel; Bonaccorsi, Stefano; Tubaro, Luciano
2015-01-01
This work is concerned with existence of weak solutions to discon- tinuous stochastic differential equations driven by multiplicative Gaus- sian noise and sliding mode control dynamics generated by stochastic differential equations with variable structure, that is with jump nonlin- earity. The treatment covers the finite dimensional stochastic systems and the stochastic diffusion equation with multiplicative noise.
The Electrical and Dynamical Properties of Biomembranes
Mosgaard, Lars Dalskov
into account the coupling between thermodynamical uctuations and the available heat reservoir. The next step is to combine the knowledge on lipid membranes subjected to an electrical eld with the knowledge on their relaxation behavior and use our understanding to attempt to re-evaluate the results of common......-dimensional layers are literally vital for the cell, as membranes work as catalysts for some of the main chemical reactions involved in cell survival and homeostasis and govern all communication between a cell and its surroundings. The focus of the work presented in this thesis is to understand how...... the physical properties of lipid membranes relate to the behavior and functional properties of biological membranes, with special attention to the role of biological membranes in nerve signal propagation. We start by exploring the properties of polar lipid membranes in order to tackle the problem...
Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles.
Ollila, Samuli; Hyvönen, Marja T; Vattulainen, Ilpo
2007-03-29
We elucidate the influence of unsaturation on single-component membrane properties, focusing on their dynamical aspects and lateral pressure profiles across the membrane. To this end, we employ atomistic molecular dynamics simulations to study five different membrane systems with varying degrees of unsaturation, starting from saturated membranes and systematically increasing the level of unsaturation, ending up with a bilayer of phospholipids containing the docosahexaenoic acid. For an increasing level of unsaturation, we find considerable effects on dynamical properties, such as accelerated dynamics of the phosphocholine head groups and glycerol backbones and speeded up rotational dynamics of the lipid molecules. The lateral pressure profile is found to be altered by the degree of unsaturation. For an increasing number of double bonds, the peak in the middle of the bilayer decreases. This is compensated for by changes in the membrane-water interface region in terms of increasing peak heights of the lateral pressure profile. Implications of the findings are briefly discussed.
Dynamic properties of network motifs contribute to biological network organization.
Robert J Prill
2005-11-01
Full Text Available Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of biological networks can be enhanced by embracing the notion that there is a deep interplay between network structure and system dynamics. Recently, many structural characteristics of these non-random networks have been identified, but dynamical implications of the features have not been explored comprehensively. We demonstrate by exhaustive computational analysis that a dynamical property--stability or robustness to small perturbations--is highly correlated with the relative abundance of small subnetworks (network motifs in several previously determined biological networks. We propose that robust dynamical stability is an influential property that can determine the non-random structure of biological networks.
Dynamical Mechanical Properties for AD90 Alumina
REN Hui-lan; NING Jian-guo; LI Ping
2007-01-01
The dynamic response of polycrystalline alumina was investigated in the pressure range of 0 -13 GPa by planar impact experiments.Velocity interferometer system for any reflector(VISAR) was used to obtain free surface velocity profile and determine the Hugoniot elastic limit,and manganin gauges were employed to obtain the stress-time histories and determine Hugoniot curve.Both the free surface particle velocity profiles and Hugoniot curves indicate the dispersion of the "plastic" wave for alumina.With the measured stress histories,the complete histories of strain,particle velocity,specific volume and specific internal energy are gained by using path line principle of Lagrange analysis.The dynamic mechanical behaviors for alumina under impact loading are analyzed,such as nonlinear characteristic,strain rate dependence,dispersion and declination of shock wave in the material.
Dynamical properties of the Lorentz gas
Sharma, K. C.; Ranganathan, S.; Egelstaff, P. A.; Soper, A. K.
1987-07-01
A Lorentz gas interacting with a Lennard-Jones (LJ) potential and obeying classical equations of motion has been simulated by the molecular-dynamics method. A system of 255 Ar particles and one H2 molecule at a reduced Ar density 0.413 and temperature 2.475 is simplified by allowing the ``argon'' to have infinite mass, and the hydrogen molecule interacts with Ar atoms via the LJ potential. The simulated incoherent dynamic structure factor Ss(Q,ω) for the hydrogen molecule, which is corrected for the rotational states, is found to be in reasonable agreement with the experimental data of Egelstaff et al. (unpublished). One-parameter phenomenological model calculations are also compared to these data.
Lee, Jin-Ho; Park, Hun-Kuk; Kim, Kyung Sook
2016-05-06
Diverse intrinsic and extrinsic mechanical factors have a strong influence on the regulation of stem cell fate. In this work, we examined recent literature on the effects of mechanical environments on stem cells, especially on differentiation of mesenchymal stem cells (MSCs). We provide a brief review of intrinsic mechanical properties of single MSC and examined the correlation between the intrinsic mechanical property of MSC and the differentiation ability. The effects of extrinsic mechanical factors relevant to the differentiation of MSCs were considered separately. The effect of nanostructure and elasticity of the matrix on the differentiation of MSCs were summarized. Finally, we consider how the extrinsic mechanical properties transfer to MSCs and then how the effects on the intrinsic mechanical properties affect stem cell differentiation.
Structural dynamic responses analysis applying differential quadrature method
PU Jun-ping; ZHENG Jian-jun
2006-01-01
Unconditionally stable higher-order accurate time step integration algorithms based on the differential quadrature method (DQM) for second-order initial value problems were applied and the quadrature rules of DQM, computing of the weighting coefficients and choices of sampling grid points were discussed. Some numerical examples dealing with the heat transfer problem, the second-order differential equation of imposed vibration of linear single-degree-of-freedom systems and double-degree-of-freedom systems, the nonlinear move differential equation and a beam forced by a changing load were computed,respectively. The results indicated that the algorithm can produce highly accurate solutions with minimal time consumption, and that the system total energy can remain conservative in the numerical computation.
Dynamic Deformation Properties of Energetic Composite Materials
2005-04-01
properties are close to that of pure beryllium ( Silversmith and Averbach 1970), but as far as we know no-one has acted on this suggestion. According to...J.L. (1998) "Analysis of load oscillations in instrumented impact testing" Engng Fract. Mech. 60 437-446 Silversmith , D.J. and Averbach, B.L. (1970
Spatial Differentiation in Industrial Dynamics. The Case of the Netherlands (1994–2005)
Capasso, Marco; Cefis, Elena; Frenken, Koen
2016-01-01
We compare the industrial dynamics in the core, semi-periphery and periphery in the Netherlands in terms of firm entry-exit, size, growth and location patterns. The contribution of our work is to provide the first comprehensive study on spatial differentiation in industrial dynamics for all firm
Taylor, Lawrence W., Jr.; Rajiyah, H.
1991-01-01
Partial differential equations for modeling the structural dynamics and control systems of flexible spacecraft are applied here in order to facilitate systems analysis and optimization of these spacecraft. Example applications are given, including the structural dynamics of SCOLE, the Solar Array Flight Experiment, the Mini-MAST truss, and the LACE satellite. The development of related software is briefly addressed.
Taylor, Lawrence W., Jr.; Rajiyah, H.
Partial differential equations for modeling the structural dynamics and control systems of flexible spacecraft are applied here in order to facilitate systems analysis and optimization of these spacecraft. Example applications are given, including the structural dynamics of SCOLE, the Solar Array Flight Experiment, the Mini-MAST truss, and the LACE satellite. The development of related software is briefly addressed.
Assessment of dynamic properties and stiffness of composite bridges with pavement defects
Kartopol'tsev, Vladimir; Kartopol'tsev, Andrei; Kolmakov, Boris
2017-01-01
This paper is aimed at assessing the dynamic properties and stiffness of the reinforced concrete roadway slab under live loads that impact composite bridge girders considering pavement defects. A special attention is paid to the reinforced concrete roadway slab as a transfer member of forced oscillations. The test results obtained for bridges with different spans ranging from 24 to 110 m are presented to assess the behavior of the reinforced concrete roadway slab and the dynamic stiffness of bridge span allowed for the pavement defects. Dynamic tests are carried out under controlled and random loads that simulate live load interaction with the span and the pavement with defects. The differential equations are presented for vertical oscillations of spans, pavement defect parameter, Eigen frequency and others. As a result of the experimental research the equation is derived to ascertain the dynamic stiffness of the vehicle-span system.
Phosphorylation dynamics during early differentiation of human embryonic stem cells
van Hoof, D.; Munoz, J.; Braam, S.R.; Pinkse, M.W.H.; Linding, R.; Heck, A.J.R.; Mummery, C.L.; Krijgsveld, J.
2009-01-01
Pluripotent stem cells self-renew indefinitely and possess characteristic protein-protein networks that remodel during differentiation. How this occurs is poorly understood. Using quantitative mass spectrometry, we analyzed the (phospho)proteome of human embryonic stem cells (hESCs) during
Differential quadrature time element method for structural dynamics
Yu-Feng Xing; Jing Guo
2012-01-01
An accurate and efficient differential quadrature time element method (DQTEM) is proposed for solving ordinary differential equations (ODEs),the numerical dissipation and dispersion of DQTEM is much smaller than that of the direct integration method of single/multi steps.Two methods of imposing initial conditions are given,which avoids the tediousness when derivative initial conditions are imposed,and the numerical comparisons indicate that the first method,in which the analog equations of initial displacements and velocities are used to directly replace the differential quadrature (DQ) analog equations of ODEs at the first and the last sampling points,respectively,is much more accurate than the second method,in which the DQ analog equations of initial conditions are used to directly replace the DQ analog equations of ODEs at the first two sampling points.On the contrary to the conventional step-by-step direct integration schemes,the solutions at all sampling points can be obtained simultaneously by DQTEM,and generally,one differential quadrature time element may be enough for the whole time domain.Extensive numerical comparisons validate the efficiency and accuracy of the proposed method.
Phosphorylation dynamics during early differentiation of human embryonic stem cells
van Hoof, D.; Munoz, J.; Braam, S.R.; Pinkse, M.W.H.; Linding, R.; Heck, A.J.R.; Mummery, C.L.; Krijgsveld, J.
2009-01-01
Pluripotent stem cells self-renew indefinitely and possess characteristic protein-protein networks that remodel during differentiation. How this occurs is poorly understood. Using quantitative mass spectrometry, we analyzed the (phospho)proteome of human embryonic stem cells (hESCs) during different
Phosphorylation dynamics during early differentiation of human embryonic stem cells
Van Hoof, Dennis; Muñoz, Javier; Braam, Stefan R
2009-01-01
Pluripotent stem cells self-renew indefinitely and possess characteristic protein-protein networks that remodel during differentiation. How this occurs is poorly understood. Using quantitative mass spectrometry, we analyzed the (phospho)proteome of human embryonic stem cells (hESCs) during...
Dynamic properties of liquid Ni revisited
del Rio B. G.
2017-01-01
Full Text Available Liquid Ni has previously been studied by different approaches such as molecular dynamics simulations and experimental techniques including inelastic neutron and X-ray scattering. Although some puzzling results, such as the shape of the sound dispersion curve for q ≤ 1.0 Å−1, have already been sorted out, there still persist some discrepancies, among different studies, for greater q-values. We have performed ab initio simulation calculations which show how those differences can be reconciled. Moreover, we have found that the transverse current spectral functions have some features which, so far, had previously been shown by high pressure liquid metals.
Dynamic Properties of Human Bronchial Airway Tissues
Wang, Jau-Yi; Pallai, Prathap; Corrigan, Chris J; Lee, Tak H
2011-01-01
Young's Modulus and dynamic force moduli were measured on human bronchial airway tissues by compression. A simple and low-cost system for measuring the tensile-strengh of soft bio-materials has been built for this study. The force-distance measurements were undertaken on the dissected bronchial airway walls, cartilages and mucosa from the surgery-removed lungs donated by lung cancer patients with COPD. Young's modulus is estimated from the initial slope of unloading force-displacement curve and the dynamic force moduli (storage and loss) are measured at low frequency (from 3 to 45 Hz). All the samples were preserved in the PBS solution at room temperature and the measurements were perfomed within 4 hours after surgery. Young's modulus of the human bronchial airway walls are fond ranged between 0.17 and 1.65 MPa, ranged between 0.25 to 1.96 MPa for cartilages, and between 0.02 to 0.28 MPa for mucosa. The storage modulus are found varying 0.10 MPa with frequency while the loss modulus are found increasing from ...
The numerical dynamic for highly nonlinear partial differential equations
Lafon, A.; Yee, H. C.
1992-01-01
Problems associated with the numerical computation of highly nonlinear equations in computational fluid dynamics are set forth and analyzed in terms of the potential ranges of spurious behaviors. A reaction-convection equation with a nonlinear source term is employed to evaluate the effects related to spatial and temporal discretizations. The discretization of the source term is described according to several methods, and the various techniques are shown to have a significant effect on the stability of the spurious solutions. Traditional linearized stability analyses cannot provide the level of confidence required for accurate fluid dynamics computations, and the incorporation of nonlinear analysis is proposed. Nonlinear analysis based on nonlinear dynamical systems complements the conventional linear approach and is valuable in the analysis of hypersonic aerodynamics and combustion phenomena.
Xu, Huidong
Negative differential conductivity (NDC) is a nonlinear property of electronic transport for high electric field strength found in materials and devices such as semiconductor superlattices, bulk GaAs and Gunn diodes. In spatially extended systems, NDC can cause rich dynamics such as static and mobile field domains and moving charge fronts. In this thesis, these phenomena are studied theoretically and numerically for semiconductor superlattices. Two classes of models are considered: a discrete model based on sequential resonant tunneling between neighboring quantum wells is used to described charge transport in weakly-coupled superlattices, and a continuum model based on the miniband transport is used to describe charge transport strongly-coupled superlattices. The superlattice is a spatially extended nonlinear system consisting a periodic arrangement of quantum wells (e.g., GaAs) and barriers (e.g., AlAs). Using a discrete model and only considering one spatial dimension, we find that the boundary condition at the injecting contact has a great influence on the dynamical behavior for both fixed voltage and transient response. Static or moving field domains are usually inevitable in this system. In order to suppress field domains, we add a side shunting layer parallel to the growth direction of the superlattice. In this case, the model includes both vertical and lateral spatial degrees of freedom. We first study a shunted weakly-coupled superlattice for a wide range of material parameters. The field domains are found to be suppressed for superlattices with small lateral size and good connection between the shunt and the quantum wells of the superlattice. As the lateral size of the superlattice increases, the uniform field configuration loses its stability to either static or dynamic field domains, regardless of shunt properties. A lower quality shunt generally leads to regular and chaotic current oscillations and complex spatio-temporal dynamics in the field profile
Dynamic properties of power MOS transistors
Belabadia, Mohammed
Power MOSFET's were modeled in dynamic high frequency and switching regimes, based on a theoretical analysis of the active region, taking into account the short channel effects and those related to structural configuration elements. The theoretical synthesis of intrinsic and parasitic elements leads to a complete nonlinear physical model compatible with electric simulators. The model is used for simulation and computer aided design of electric circuits which use power MOSFET's such as RF amplifiers, and frequency doublers. For the switching regime, a hierarchy of models for power V.DMOS transistors is developed. Two compact models consistent with SPICE-2 program and well suited for study and characterization of power V.DMOSFET, in switching condition under resistive and inductive loads, are proposed. They can describe low, medium, and high voltage structures.
Dynamic mechanical properties of an inlay composite.
Dionysopoulos, P; Watts, D C
1989-06-01
A visible light-cured composite resin (Brilliant DI) has been studied over a wide range of temperature and frequency by a dynamic mechanical flexural method. The derived data of logarithmic modulus and loss tangent (tan delta) show considerable changes following a secondary-cure process applied to the material. This involved the application of heat and intense light with temperatures rising to 120 degrees C in 7 min. Following this oven-cure the resin phase exhibited enhanced stiffness with the activation-energy barrier for molecular motion at the glass-transition rising from 220 to 291 kJ/mol. This study clarifies the nature and extent of the internal molecular changes which may be produced in the fabrication of a composite inlay.
Dynamic Properties of Fiber Reinforced Cement Mortar
唐志平; 徐松林; 胡晓军; 廖香丽; 蔡建
2004-01-01
Based on the shear wave tracing(SWT) technique proposed by Tang Z P, particle velocity gauge and the dual internal measurement for pressure and shear waves (IMPS) system are applied to investigate the responses of fiber reinforced cement subjected to impact loading. Series of experiments are conducted. The results show that there exist four critical points, A, B, C, D, in p-V Hugoniot curves. They correspond to the Hugoniot elastic limit (HEL) of the material, the critical point for shear strength limit and transition from damage state to failure state, void collapse, and solid compression, respectively. The critical point B is difficult to be aware of and never reported. However, it can be clearly disclosed with SWT method. Based on the analyses of shear strength, it can be concluded that the transversal wave, especially the unloading transversal wave, is especially important for the dynamic damage investigation of brittle materials.
Peculiar dynamical properties of plutonium hydrides
无
2006-01-01
In the present work, the structure and spectra of PuH and PuH2 are defined by B3LYP/SDD method, from which the analytic potential energy function of PuH2 is derived. The analysis of quasi-classical molecular reaction dynamics is performed to study the state-state process of pu(7Fg) + H2(X1∑+g ). It is found that the reaction pu(7Fg) + H2(X1∑+g )→PuH2(X7B1) has no threshold. The simultaneous hydrogenation process of plutonium with the main product of PuH2 is theoretically proved for the first time.
Diversity and non-integer differentiation for system dynamics
Oustaloup, Alain
2014-01-01
Based on a structured approach to diversity, notably inspired by various forms of diversity of natural origins, Diversity and Non-integer Derivation Applied to System Dynamics provides a study framework to the introduction of the non-integer derivative as a modeling tool. Modeling tools that highlight unsuspected dynamical performances (notably damping performances) in an ""integer"" approach of mechanics and automation are also included. Written to enable a two-tier reading, this is an essential resource for scientists, researchers, and industrial engineers interested in this subject area. Ta
Differential representations of dynamical oscillator symmetries in discrete Hilbert space
Andreas Ruffing
2000-01-01
Full Text Available As a very important example for dynamical symmetries in the context of q-generalized quantum mechanics the algebra aa†−q−2a†a=1 is investigated. It represents the oscillator symmetry SUq(1,1 and is regarded as a commutation phenomenon of the q-Heisenberg algebra which provides a discrete spectrum of momentum and space, i.e., a discrete Hilbert space structure. Generalized q-Hermite functions and systems of creation and annihilation operators are derived. The classical limit q→1 is investigated. Finally the SUq(1,1 algebra is represented by the dynamical variables of the q-Heisenberg algebra.
Structural and dynamic properties of LiNO3 + Al2O3 nanocomposites
Gafurov, M. M.; Rabadanov, K. Sh.; Ataev, M. B.; Amirov, A. M.; Kubataev, Z. Yu.; Kakagasanov, M. G.
2015-10-01
The structural and dynamic properties of lithium nitrate LiNO3 and its heterogeneous composites with a nanopowder of aluminum oxide Al2O3 at different temperatures, phase states, and concentrations of the Al2O3 nanopowder have been investigated using Raman scattering, differential thermal analysis, and X-ray diffraction. It has been shown that, in the (1- x)LiNO3 + xAl2O3 composites, an amorphous phase (for x ≥ 0.5) is formed, whose thermal effect is observed at 185°C. The calculations of the dynamic characteristics of vibrations of the nitrate ion, as well as the differential thermal and X-ray diffraction analyses, have demonstrated that the nanocomposite can be represented as a highly disordered "quasilattice" in which "sites" are occupied by nanoparticles with amorphous lithium nitrate shells and spaces between them (conventionally "interstitial sites") become channels of a facilitated flow of the ion current.
Molecular Dynamics Simulation on thermodynamic Properties and Transport Coefficients
D.X.Xiong
1996-01-01
Moecular dynamics simulation (MDS) is used to study the thermodynamic properties and transport coefficients of an argon system with Lennend-Jones potential.The results on the velocity distribution,mean free path,mean collison time,specific heat and self0diffusion coefficient agree well with the existing theoretical /experimental data,It shows that molecular dynamics method is another bridge to connect microworld and macreoworld.
Asymptotic stability properties of θ-methods for delay differential equations
无
2001-01-01
Deals with the asymptotic stability properties of θ- methods for the pantograph equation and the linear delay differential-algebraic equation with emphasis on the linear θ- methods with variable stepsize schemes for the pantograph equation, proves that asymptotic stability is obtained if and only if θ ＞ 1/2, and studies further the one-leg θ- method for the linear delay differential-algebraic equation and establishes the sufficient asymptotic-ally differential-algebraic stable condition θ = 1.
Properties of Differential Scattering Section Based on Multi-photon Nonlinear Compton Effect
无
2002-01-01
Properties of damping electrons in collision with photons based on multi-photon nonlinear Compton effect are investigated. The expressions of the differential scattering section are derived. Several useful conclusions are drawn.
The Symmetry of Singular Hamiltonian Differential Operators and Properties of Deficiency Indices
Jian Gang QI
2006-01-01
The symmetry of singular Hamiltonian differential operators is proved under the standard "definiteness condition", which is strictly weaker than the densely definite condition used by A. M.Krall. Meanwhile, some properties of deficiency indices are given.
SPECTRAL PROPERTIES OF SECOND ORDER DIFFERENTIAL OPERATORS ON TWO-STEP NILPOTENT LIE GROUPS
Niu Pengcheng
2000-01-01
In this paper, spectral properties of certain left invariant differential operators on two-step nilpotent Lie groups are completely described by using the theory of unitary irreducible representations and the Plancherel formulae on nilpotent Lie groups.
Some Properties of Stochastic Differential Equations Driven by the G-Brownian Motion
Qian LIN
2013-01-01
In this paper,we study the property of continuous dependence on the parameters of stochastic integrals and solutions of stochastic differential equations driven by the G-Brownian motion.In addition,the uniqueness and comparison theorems for those stochastic differential equations with non-Lipschitz coefficients are obtained.
Some analytical properties of solutions of differential equations of noninteger order
S. M. Momani
2004-01-01
Full Text Available The analytical properties of solutions of the nonlinear differential equations x(α(t=f(t,x, α∈ℝ, 0<α≤1 of noninteger order have been investigated. We obtained two results concerning the frame curves of solutions. Moreover, we proved a result on differential inequality with fractional derivatives.
OPTICAL AND DYNAMIC PROPERTIES OF UNDOPED AND DOPED SEMICONDUCTOR NANOSTRUCTURES
Grant, C D; Zhang, J Z
2007-09-28
This chapter provides an overview of some recent research activities on the study of optical and dynamic properties of semiconductor nanomaterials. The emphasis is on unique aspects of these properties in nanostructures as compared to bulk materials. Linear, including absorption and luminescence, and nonlinear optical as well as dynamic properties of semiconductor nanoparticles are discussed with focus on their dependence on particle size, shape, and surface characteristics. Both doped and undoped semiconductor nanomaterials are highlighted and contrasted to illustrate the use of doping to effectively alter and probe nanomaterial properties. Some emerging applications of optical nanomaterials are discussed towards the end of the chapter, including solar energy conversion, optical sensing of chemicals and biochemicals, solid state lighting, photocatalysis, and photoelectrochemistry.
Automatic differentiation tools in the dynamic simulation of chemical engineering processes
Castro M.C.
2000-01-01
Full Text Available Automatic Differentiation is a relatively recent technique developed for the differentiation of functions applicable directly to the source code to compute the function written in standard programming languages. That technique permits the automatization of the differentiation step, crucial for dynamic simulation and optimization of processes. The values for the derivatives obtained with AD are exact (to roundoff. The theoretical exactness of the AD comes from the fact that it uses the same rules of differentiation as in differential calculus, but these rules are applied to an algorithmic specification of the function rather than to a formula. The main purpose of this contribution is to discuss the impact of Automatic Differentiation in the field of dynamic simulation of chemical engineering processes. The influence of the differentiation technique on the behavior of the integration code, the performance of the generated code and the incorporation of AD tools in consistent initialization tools are discussed from the viewpoint of dynamic simulation of typical models in chemical engineering.
Faraday resonance in dynamical bar instability of differentially rotating stars
Saijo, Motoyuki
2008-01-01
We investigate the nonlinear behaviour of the dynamically unstable rotating star for the bar mode by three-dimensional hydrodynamics in Newtonian gravity. We find that an oscillation along the rotation axis is induced throughout the growth of the unstable bar mode, and that its characteristic frequency is twice as that of the bar mode, which oscillates mainly along the equatorial plane. A possibility to observe Faraday resonance in gravitational waves is demonstrated and discussed.
Dynamic properties of the posterior cricoarytenoid muscle.
Cooper, D S; Shindo, M; Sinha, U; Hast, M H; Rice, D H
1994-12-01
The aim of this research was to investigate the contractile properties of the posterior cricoarytenoid (PCA) muscle. Simultaneous measurements were made of the isometric force, temperature, and electromyographic activity of the dorsal cricoarytenoid muscle of anesthetized dogs during supramaximal stimulation of the recurrent laryngeal nerve for twitch and tetanic contraction. The conduction delay between stimulation of the recurrent nerve at the level of the larynx and the onset of the muscle action potential averaged 2.0 +/- 0.2 milliseconds (ms), and the latent period between the onset of electrical activity of the muscle and the onset of contraction had a mean duration of 3.3 +/- 0.8 ms. The mean of isometric contraction times found was 33.3 +/- 2.0 ms, shorter than most previous studies of canine PCA muscle. Tetanic frequency defined as smooth contraction was higher than previous estimates. Considerations of scaling of physiological time based on animal mass were applied to analysis of the experimental findings to make possible systematic comparison of previous findings across species and animal size.
Morphology, crystallization and dynamic mechanical properties of PA66/nano-SiO2 composites
Huimin Lu; Xiangmin Xu; Xiaohong Li; Zhijun Zhang
2006-10-01
This article addresses the effect of nano-SiO2 on the morphology, crystallization and dynamic mechanical properties of polyamide 66. The influence of nano-SiO2 on the tensile fracture morphology of the nanocomposites was studied by scanning electron microscopy (SEM), which suggested that the nanocomposites revealed an extensive plastic stretch of the matrix polymer. The crystallization behaviour of polyamide 66 and its nanocomposites were studied by differential scanning calorimetry (DSC). DSC nonisothermal curves showed an increase in the crystallization temperature along with increasing degree of crystallinity. Dynamic mechanical properties (DMA) indicated significant improvement in the storage modulus and loss modulus compared with neat polyamide 66. The tan ä peak signifying the glass-transition temperature of nanocomposites shifted to higher temperature.
Veli; B; SHAKHMUROV
2008-01-01
The unique continuation theorems for the anisotropic partial differential-operator equations with variable coeffcients in Banach-valued Lp-spaces are studied.To obtain the uniform maximal regularity and the Carleman type estimates for parameter depended differential-operator equations,the suffcient conditions are founded.By using these facts,the unique continuation properties are established.In the application part,the unique continuation properties and Carleman estimates for finite or infinite systems of quasielliptic partial differential equations are studied.
Quantified Differential Dynamic Logic for Distributed Hybrid Systems
2010-05-01
manual semantic reasoning. Other process- algebraic approaches, like χ [23], have been developed for modeling and sim- ulation. Verification is still...f(~s) using vectorial notation and we use ~s = ~t for element-wise equality. Formulas The formulas of QdL are defined as in first-order dynamic logic...like a Kleene algebra with tests [14]. QHPs are defined by the following grammar (α, β are QHPs, θ a term, i a variable of sort C, f is a function symbol
Theory of static and dynamic properties of Gd
Lindgård, Per-Anker
1986-01-01
Gadolinium is a Heisenberg magnet intermediate between the localized EuO and the itinerant Fe and Ni. The authors develop a correlation theory for Gd and calculate self-consistently both static and dynamic properties. One finds that the high frequency spin waves persist for T>Tc. The static...
Multiscale functions, Scale dynamics and Applications to partial differential equations
Cresson, Jacky
2015-01-01
Modeling phenomena from experimental data, always begin with a \\emph{choice of hypothesis} on the observed dynamics such as \\emph{determinism}, \\emph{randomness}, \\emph{derivability} etc. Depending on these choices, different behaviors can be observed. The natural question associated to the modeling problem is the following : \\emph{"With a finite set of data concerning a phenomenon, can we recover its underlying nature ?} From this problem, we introduce in this paper the definition of \\emph{multi-scale functions}, \\emph{scale calculus} and \\emph{scale dynamics} based on the \\emph{time-scale calculus} (see \\cite{bohn}). These definitions will be illustrated on the \\emph{multi-scale Okamoto's functions}. The introduced formalism explains why there exists different continuous models associated to an equation with different \\emph{scale regimes} whereas the equation is \\emph{scale invariant}. A typical example of such an equation, is the \\emph{Euler-Lagrange equation} and particularly the \\emph{Newton's equation} ...
Viscoelastic and dynamic properties of embryonic stem cells
Ritter, Christine
ofthe cells themselves. In this thesis, the viscoelastic properties of mouse embryonic stem cells primedeither toward the epiblast (Epi) or the primitive endoderm (PrE) lineage were investigated.Optical tweezers were used to measure the fluctuations of endogenous lipid granules and therebydraw......Stem cells are often referred to as the ‘holy grail’ of regenerative medicine, because they possessthe ability to develop into any cell type. The use of stem cells within medicine is currently limited bythe effectivity of differentiation and cell reprogramming protocols, making it therefore...... imperative tounderstand stem cells’ differentiation mechanisms better. Studies have shown that mechanical cuescan have an influence on stem cell fate decision. However, in order to understand the reaction of stemcells to mechanical input, one should first investigate and understand the mechanical properties...
Viscoelastic and dynamic properties of embryonic stem cells
Ritter, Christine
Stem cells are often referred to as the ‘holy grail’ of regenerative medicine, because they possessthe ability to develop into any cell type. The use of stem cells within medicine is currently limited bythe effectivity of differentiation and cell reprogramming protocols, making it therefore...... imperative tounderstand stem cells’ differentiation mechanisms better. Studies have shown that mechanical cuescan have an influence on stem cell fate decision. However, in order to understand the reaction of stemcells to mechanical input, one should first investigate and understand the mechanical properties...... ofthe cells themselves. In this thesis, the viscoelastic properties of mouse embryonic stem cells primedeither toward the epiblast (Epi) or the primitive endoderm (PrE) lineage were investigated.Optical tweezers were used to measure the fluctuations of endogenous lipid granules and therebydraw...
Emergent Properties in Natural and Artificial Dynamical Systems
Aziz-Alaoui, M.A
2006-01-01
An important part of the science of complexity is the study of emergent properties arising through dynamical processes in various types of natural and artificial systems. This is the aim of this book, which is the outcome of a discussion meeting within the first European conference on complex systems. It presents multidisciplinary approaches for getting representations of complex systems and using different methods to extract emergent structures. This carefully edited book studies emergent features such as self organization, synchronization, opening on stability and robustness properties. Invariant techniques are presented which can express global emergent properties in dynamical and in temporal evolution systems. This book demonstrates how artificial systems such as a distributed platform can be used for simulation used to search emergent placement during simulation execution.
Analysis of planetary evolution with emphasis on differentiation and dynamics
Kaula, William M.; Newman, William I.
1987-01-01
In order to address the early stages of nebula evolution, a three-dimensional collapse code which includes not only hydrodynamics and radiative transfer, but also the effects of ionization and, possibly, magnetic fields is being addressed. As part of the examination of solar system evolution, an N-body code was developed which describes the latter stages of planet formation from the accretion of planetesimals. To test the code for accuracy and run-time efficiency, and to develop a stronger theoretical foundation, problems were studied in orbital dynamics. A regional analysis of the correlation in the gravity and topography fields of Venus was performed in order to determine the small and intermediate scale subsurface structure.
Sperm competition dynamics: ejaculate fertilising efficiency changes differentially with time
Burke Terry
2008-12-01
Full Text Available Abstract Background A fundamental challenge in evolutionary biology is to resolve the mechanisms that maintain paternity a hypervariable fitness component. Because females are often sexually promiscuous, this challenge hinges on establishing the mechanisms through which the ejaculates of different males compete for fertilisation (sperm competition. The competitive quality of an ejaculate is mediated by the relative number of live sperm and their motile performance. The differential rate at which rival ejaculates lose their fertilising efficiency over time is therefore expected to influence the outcome of sperm competition. Results Here, we artificially inseminated into sets of replicate domestic hens, Gallus gallus domesticus, experimentally engineered heterospermic ejaculates containing a large number of low-quality sperm from one male, and a lower number of high-quality sperm from another male. Large, low-quality ejaculates fertilised the first eggs produced after insemination, but small, high-quality ejaculates prevailed in the long run despite their numerical disadvantage. Conclusion Together, these results provide the first experimental demonstration that the relative competitive value of an ejaculate changes drastically over the time during which competing ejaculates are stored within the reproductive tract of a female, resulting in a marked temporal pattern of variation in paternity. A high level of replication makes these results robust. However, our study was restricted to few males of a well characterised study population, and future work should explore the generality of these results.
Sperm competition dynamics: ejaculate fertilising efficiency changes differentially with time
2008-01-01
Background A fundamental challenge in evolutionary biology is to resolve the mechanisms that maintain paternity a hypervariable fitness component. Because females are often sexually promiscuous, this challenge hinges on establishing the mechanisms through which the ejaculates of different males compete for fertilisation (sperm competition). The competitive quality of an ejaculate is mediated by the relative number of live sperm and their motile performance. The differential rate at which rival ejaculates lose their fertilising efficiency over time is therefore expected to influence the outcome of sperm competition. Results Here, we artificially inseminated into sets of replicate domestic hens, Gallus gallus domesticus, experimentally engineered heterospermic ejaculates containing a large number of low-quality sperm from one male, and a lower number of high-quality sperm from another male. Large, low-quality ejaculates fertilised the first eggs produced after insemination, but small, high-quality ejaculates prevailed in the long run despite their numerical disadvantage. Conclusion Together, these results provide the first experimental demonstration that the relative competitive value of an ejaculate changes drastically over the time during which competing ejaculates are stored within the reproductive tract of a female, resulting in a marked temporal pattern of variation in paternity. A high level of replication makes these results robust. However, our study was restricted to few males of a well characterised study population, and future work should explore the generality of these results. PMID:19087292
Effect of roscovitine on intracellular calcium dynamics: differential enantioselective responses.
Tamma, Grazia; Ranieri, Marianna; Di Mise, Annarita; Spirlì, Alessia; Russo, Annamaria; Svelto, Maria; Valenti, Giovanna
2013-12-02
Cyclin-dependent kinases (CDKs) inhibitors have emerged as interesting therapeutic candidates. Of these, (S)-roscovitine has been proposed as potential neuroprotective molecule for stroke while (R)-roscovitine is currently entering phase II clinical trials against cancers and phase I clinical tests against glomerulonephritis. In addition, (R)-roscovitine has been suggested as potential antihypertensive and anti-inflammatory drug. Dysfunction of intracellular calcium balance is a common denominator of these diseases, and the two roscovitine enantiomers (S and R) are known to modulate calcium voltage channel activity differentially. Here, we provide a detailed description of short- and long-term responses of roscovitine on intracellular calcium handling in renal epithelial cells. Short-term exposure to (S)-roscovitine induced a cytosolic calcium peak, which was abolished after stores depletion with cyclopiazonic acid (CPA). Instead, (R)-roscovitine caused a calcium peak followed by a small calcium plateau. Cytosolic calcium response was prevented after stores depletion. Bafilomycin, a selective vacuolar H(+)-ATPase inhibitor, abolished the small calcium plateau. Long-term exposure to (R)-roscovitine significantly reduced the basal calcium level compared to control and (S)-roscovitine treated cells. However, both enantiomers increased calcium accumulation in the endoplasmic reticulum (ER). Consistently, cells treated with (R)-roscovitine showed a significant increase in SERCA activity, whereas (S)-roscovitine incubation resulted in a reduced PMCA expression. We also found a tonic decreased ability to release calcium from the ER, likely via IP3 signaling, under treatment with (S)- or (R)-roscovitine. Together our data revealed that (S)-roscovitine and (R)-roscovitine exert distinct enantiospecific effects on intracellular calcium signaling in renal epithelial cells. This distinct pharmacological profile can be relevant for roscovitine clinical use.
Proteome Dynamics during Plastid Differentiation in Rice1[W
Kleffmann, Torsten; von Zychlinski, Anne; Russenberger, Doris; Hirsch-Hoffmann, Matthias; Gehrig, Peter; Gruissem, Wilhelm; Baginsky, Sacha
2007-01-01
We have analyzed proteome dynamics during light-induced development of rice (Oryza sativa) chloroplasts from etioplasts using quantitative two-dimensional gel electrophoresis and tandem mass spectrometry protein identification. In the dark, the etioplast allocates the main proportion of total protein mass to carbohydrate and amino acid metabolism and a surprisingly high number of proteins to the regulation and expression of plastid genes. Chaperones, proteins for photosynthetic energy metabolism, and enzymes of the tetrapyrrole pathway were identified among the most abundant etioplast proteins. The detection of 13 N-terminal acetylated peptides allowed us to map the exact localization of the transit peptide cleavage site, demonstrating good agreement with the prediction for most proteins. Based on the quantitative etioplast proteome map, we examined early light-induced changes during chloroplast development. The transition from heterotrophic metabolism to photosynthesis-supported autotrophic metabolism was already detectable 2 h after illumination and affected most essential metabolic modules. Enzymes in carbohydrate metabolism, photosynthesis, and gene expression were up-regulated, whereas enzymes in amino acid and fatty acid metabolism were significantly decreased in relative abundance. Enzymes involved in nucleotide metabolism, tetrapyrrole biosynthesis, and redox regulation remained unchanged. Phosphoprotein-specific staining at different time points during chloroplast development revealed light-induced phosphorylation of a nuclear-encoded plastid RNA-binding protein, consistent with changes in plastid RNA metabolism. Quantitative information about all identified proteins and their regulation by light is available in plprot, the plastid proteome database (http://www.plprot.ethz.ch). PMID:17189339
Differential Colonization Dynamics of Cucurbit Hosts by Erwinia tracheiphila.
Vrisman, Cláudio M; Deblais, Loïc; Rajashekara, Gireesh; Miller, Sally A
2016-07-01
Bacterial wilt is one of the most destructive diseases of cucurbits in the Midwestern and Northeastern United States. Although the disease has been studied since 1900, host colonization dynamics remain unclear. Cucumis- and Cucurbita-derived strains exhibit host preference for the cucurbit genus from which they were isolated. We constructed a bioluminescent strain of Erwinia tracheiphila (TedCu10-BL#9) and colonization of different cucurbit hosts was monitored. At the second-true-leaf stage, Cucumis melo plants were inoculated with TedCu10-BL#9 via wounded leaves, stems, and roots. Daily monitoring of colonization showed bioluminescent bacteria in the inoculated leaf and petiole beginning 1 day postinoculation (DPI). The bacteria spread to roots via the stem by 2 DPI, reached the plant extremities 4 DPI, and the plant wilted 6 DPI. However, Cucurbita plants inoculated with TedCu10-BL#9 did not wilt, even at 35 DPI. Bioluminescent bacteria were detected 6 DPI in the main stem of squash and pumpkin plants, which harbored approximately 10(4) and 10(1) CFU/g, respectively, of TedCu10-BL#9 without symptoms. Although significantly less systemic plant colonization was observed in nonpreferred host Cucurbita plants compared with preferred hosts, the mechanism of tolerance of Cucurbita plants to E. tracheiphila strains from Cucumis remains unknown.
Effects of Fibers on the Dynamic Properties of Asphalt Mixtures
无
2007-01-01
The dynamic characteristics of fiber-modified asphalt mixture were investigated. Cellulose fiber, polyester fiber and mineral fiber were used as additives for asphalt mixture, and the dosage was 0.3%, 0.3%,0.4%, respectively. Dynamic modulus test using SuperPave simple performance tester (SPT) was conducted to study the dynamic modulus (E*) and phase angle (δ) for the control asphalt mixture and fiber-modified ones at various temperatures and frequencies. Experimental results show that all fiber-modified asphalt mixtures have higher dynamic modulus compared with control mixture. The dynamic modulus master curves of each type of asphalt mixtures are determined based on nonlinear least square regression in accordance with the timetemperature superposition theory at a control temperature (21.1 ℃). The fatigue parameter E*×sinδ and rutting parameter E*/sinδ of asphalt mixture are adopted to study the fatigue and rutting-resistance properties, and experimental results indicate that such properties can be improved by fiber additives.
Evolution properties of the community members for dynamic networks
Yang, Kai; Guo, Qiang; Li, Sheng-Nan; Han, Jing-Ti; Liu, Jian-Guo
2017-03-01
The collective behaviors of community members for dynamic social networks are significant for understanding evolution features of communities. In this Letter, we empirically investigate the evolution properties of the new community members for dynamic networks. Firstly, we separate data sets into different slices, and analyze the statistical properties of new members as well as communities they joined in for these data sets. Then we introduce a parameter φ to describe community evolution between different slices and investigate the dynamic community properties of the new community members. The empirical analyses for the Facebook, APS, Enron and Wiki data sets indicate that both the number of new members and joint communities increase, the ratio declines rapidly and then becomes stable over time, and most of the new members will join in the small size communities that is s ≤ 10. Furthermore, the proportion of new members in existed communities decreases firstly and then becomes stable and relatively small for these data sets. Our work may be helpful for deeply understanding the evolution properties of community members for social networks.
The scaling properties of dynamical fluctuations in temporal networks
Chi, Liping
2015-01-01
The factorial moments analyses are performed to study the scaling properties of the dynamical fluctuations of contacts and nodes in temporal networks based on empirical data sets. The intermittent behaviors are observed in the fluctuations for all orders of the moments. It indicates that the interaction has self-similarity structure in time interval and the fluctuations are not purely random but dynamical and correlated. The scaling exponents for contacts in Prostitution data and nodes in Conference data are very close to that for 2D Ising model undergoing a second-order phase transition.
The fluorescence and dynamics properties in phenoxy-phthalocyanines liquid
Yao, Cheng-Bao; Yan, Xiao-Yan; Tan, Ming-Yue; Li, Jin; Sun, Wen-Jun; Yang, Shou-Bin
2015-06-01
We investigated the one/two-photon fluorescence and excited state dynamics properties of two synthesized phenoxy-phthalocyanines (Pc1 and Pc2) using mild reaction coordination method. The results show that the fast decay component in the time-resolved fluorescence technique dynamics comes from the intramolecular vibrational relaxation, the slower ones from the internal conversion. Furthermore, in comparison with one-photon fluorescence spectra, the red shift of two-photon fluorescence spectra can be explained by the reabsorption effect of molecules. The samples are expected to be a potential candidate for optical applications and photodynamic therapy.
Application of Electrical Properties to Differentiate Lard from Tallow and Palm Oil
Sucipto
2013-04-01
Full Text Available This study aimed to differentiate lard from tallow and palm oil based on its electrical properties, namely conductance, impedance and capacitance. These properties were measured at spectra frequencies of 4.20 to 5.00 MHz in room temperature (26-27 oC. Statistic multivariate that consist on principal component analysis (PCA and cluster analysis (CA were used to evaluate the data. The results showed that lard and tallow can be differentiated using whole parameters electrical properties of materials. On the other hand, lard and palm oil can only be differentiated using part of the material electrical properties. Good performance of differentiation process was obtained using PCA model at 4.91 to 4.98 MHz. The first two components of PCA, which was derived from conductance, impedance and capacitance, contributed more than 90% of the total variances. CA showed that lard and tallow are different groups based on the Euclidean distance of each electrical properties. This technique can be potentially developed as an electrical sensor for differentiation lard to tallow and palm oil.
Recycling probability and dynamical properties of germinal center reactions
Meyer-Hermann, M; Or-Guil, M; Meyer-Hermann, Michael; Deutsch, Andreas; Or-Guil, Michal
2001-01-01
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al.(1995) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns to be necessary for the optimization process ...
A stochastic differential equation framework for the timewise dynamics of turbulent velocities
Barndorff-Nielsen, Ole Eiler; Schmiegel, Jürgen
2008-01-01
We discuss a stochastic differential equation as a modeling framework for the timewise dynamics of turbulent velocities. The equation is capable of capturing basic stylized facts of the statistics of temporal velocity increments. In particular, we focus on the evolution of the probability density...
Anders Gjelsvik
1982-07-01
Full Text Available A first-order differential dynamic programming (DDP algorithm is used for computing optimal control for a five-reservoir system, where the stochastic inflow process has been approximated by a few discrete disturbance values in each time step. The method is found to be faster than linear programming, previously tried on the same system model.
On the stability of nonautonomous binary dynamical systems of partial differential equations
Salvatore Rionero
2013-01-01
Full Text Available Nonlinear nonautonomoua binary reaction-diffusion dynamical systems of partial differential equations (PDE are considered. Stability criteria - via a nonautonomous L²-energy - are obtained. Applications to nonautonomous Lotka-volterra systems of PDEs and to “preys” struggle for the life, are furnished.
Winkel, Brian
2012-01-01
We give an example of cross coursing in which a subject or approach in one course in undergraduate mathematics is used in a completely different course. This situation crosses falling body modelling in an upper level differential equations course into a modest discrete dynamical systems unit of a first-year mathematics course. (Contains 1 figure.)
Yao-lin Jiang
2003-01-01
In this paper we presented a convergence condition of parallel dynamic iteration methods for a nonlinear system of differential-algebraic equations with a periodic constraint.The convergence criterion is decided by the spectral expression of a linear operator derivedfrom system partitions. Numerical experiments given here confirm the theoretical work ofthe paper.
Batalin, Igor A.; Lavrov, Peter M.
2017-04-01
For topological sigma models, we propose that their local Lagrangian density is allowed to depend non-linearly on the de Rham's "velocities" DZA. Then, by differentiating the Lagrangian density with respect to the latter de Rham's "velocities", we define a "dynamical" anti-symplectic potential, in terms of which a "dynamical" anti-symplectic metric is defined, as well. We define the local and the functional antibracket via the dynamical anti-symplectic metric. Finally, we show that the generalized action of the sigma model satisfies the functional master equation, as required.
Application of Stochastic Partial Differential Equations to Reservoir Property Modelling
Potsepaev, R.
2010-09-06
Existing algorithms of geostatistics for stochastic modelling of reservoir parameters require a mapping (the \\'uvt-transform\\') into the parametric space and reconstruction of a stratigraphic co-ordinate system. The parametric space can be considered to represent a pre-deformed and pre-faulted depositional environment. Existing approximations of this mapping in many cases cause significant distortions to the correlation distances. In this work we propose a coordinate free approach for modelling stochastic textures through the application of stochastic partial differential equations. By avoiding the construction of a uvt-transform and stratigraphic coordinates, one can generate realizations directly in the physical space in the presence of deformations and faults. In particular the solution of the modified Helmholtz equation driven by Gaussian white noise is a zero mean Gaussian stationary random field with exponential correlation function (in 3-D). This equation can be used to generate realizations in parametric space. In order to sample in physical space we introduce a stochastic elliptic PDE with tensor coefficients, where the tensor is related to correlation anisotropy and its variation is physical space.
Dynamic properties of fuzzy Petri net model and related analysis
周恺卿; Azlan Mohd Zain; 莫礼平
2015-01-01
Fuzzy Petri net (FPN) has been extensively applied in industrial fields for knowledge-based systems or systems with uncertainty. Although the applications of FPN are known to be successful, the theoretical research of FPN is still at an initial stage. To pave a way for further study, this work explores related dynamic properties of FPN including reachability, boundedness, safeness, liveness and fairness. The whole methodology is divided into two phases. In the first phase, a comparison between elementary net system (EN_system) and FPN is established to prove that the FPN is an extensive formalism of Petri nets using a backwards-compatible extension method. Next, current research results of dynamic properties are utilized to analyze FPN model. The results illustrate that FPN model is bounded, safe, weak live and fair, and can support theoretical evidences for designing related decomposition algorithm.
Nonlinear Analyses of the Dynamic Properties of Hydrostatic Bearing Systems
LIU Wei(刘伟); WU Xiujiang(吴秀江); V.A. Prokopenko
2003-01-01
Nonlinear analyses of hydrostatic bearing systems are necessary to adequately model the fluid-solid interaction. The dynamic properties of linear and nonlinear analytical models of hydrostatic bearings are compared in this paper. The analyses were based on the determination of the aperiodic border of transient processes with external step loads. The results show that the dynamic properties can be most effectively improved by increasing the hydrostatic bearing crosspiece width and additional pocket volume in a bearing can extend the load range for which the transient process is aperiodic, but an additional restrictor and capacitor (RC) chain must be introduced for increasing damping. The nonlinear analyses can also be used to predict typical design parameters for a hydrostatic bearing.
刘安平; 何猛省
2002-01-01
By making use of the integral inequalities and some results of the functional differential equations, oscillatory properties of solutions of certain nonlinear hyperbolic partial differential equations of neutral type with multi-delays were investigated and a series of sufficient conditions for oscillations of the equations were established. The results fully indicate that the oscillations are caused by delay and hence reveal the difference between these equations and those equations without delay.
Comparison of static and dynamic properties in a shale rock
Bonnelye, Audrey; Pimienta, Lucas; Schubnel, Alexandre; David, Christian
2017-04-01
When trying to understand the elastic properties of rocks in order to ultimately compare laboratory and field data, two opposite measuring techniques can be used: the "static" and "dynamic" measurement techniques. The "static" measurement technique consists in characterising the medium by its strain response to an applied stress. The strain rate is generally low enough that the measurement can be addressed as static. Using ultrasonic wave velocity, the "dynamic" measurements are obtained. Those allow obtaining accurately the full set of elastic constants characterising the medium. However, such measuring procedure is at high frequency, implying the risk for dispersion and attenuation effects to occur. When comparing the "static" and "dynamic" measurements, and investigating their differences, the effect of the measuring frequency is often the parameter considered. However, it is not the only parameter that may play a role. Indeed, often, "static" measurements rely on strain amplitudes above 10-4. On the other hand, "dynamic" measurements rely on strain amplitudes below 10-6. Such difference may play an important role in comparing measurements in weak materials such as shales. For this particular rock, the effect of strain amplitude on the "static" measurements is investigated by decreasing the amplitude of stress variations. Moreover, due to both multiscale and sedimentary nature, shale materials can exhibit strong anisotropic properties, usually described as transversly isotropic. In this study we propose to compare the different ways of measuring elastic moduli of Tournemire shale (IRSN underground laboratory, Aveyron, Southern France). In a first part, static moduli were calculated on three sets of samples with different bedding orientations (90°, 0°, 45°) deformed under deviatoric pressure at different confining pressures (2.5, 5, 10, 20, 40, 80MPa). During these deformation experiments, elastic wave velocities were continuously measured along different
Applications of differential algebra to single-particle dynamics in storage rings
Yan, Y.
1991-09-01
Recent developments in the use of differential algebra to study single-particle beam dynamics in charged-particle storage rings are the subject of this paper. Chapter 2 gives a brief review of storage rings. The concepts of betatron motion and synchrotron motion, and their associated resonances, are introduced. Also introduced are the concepts of imperfections, such as off-momentum, misalignment, and random and systematic errors, and their associated corrections. The chapter concludes with a discussion of numerical simulation principles and the concept of one-turn periodic maps. In Chapter 3, the discussion becomes more focused with the introduction of differential algebras. The most critical test for differential algebraic mapping techniques -- their application to long-term stability studies -- is discussed in Chapter 4. Chapter 5 presents a discussion of differential algebraic treatment of dispersed betatron motion. The paper concludes in Chapter 6 with a discussion of parameterization of high-order maps.
ASSESSMENT OF THE DYNAMIC PROPERTIES OF PLAIN AND RUBBERIZED CONCRETE
Ionuţ Ovidiu TOMA
2015-11-01
Full Text Available The use of rubber from discarded car tires as an alternative to natural aggregates in concrete may help preventing the complete depletion of natural resources and work towards a sustainable future. Moreover it can significantly reduce the environmental footprint of the construction industry. The assessment of the dynamic properties of a material are very important from the point of view of the energy dissipation capability of the investigated material. This can be determined from the dynamic modulus of elasticity, damping and the loss coefficients of the material. The paper presents the results obtained during an experimental program aimed at assessing the dynamic characteristics of plain and rubberized concrete containing rubber crumbs from discarded car tires. The theoretical background and the investigation methodology are presented with particular application to cylindrical concrete specimens.
Characterisation of Dynamic Mechanical Properties of Resistance Welding Machines
Wu, Pei; Zhang, Wenqi; Bay, Niels
2005-01-01
The dynamic mechanical properties of a resistance welding machine have significant influence on weld quality, which must be considered when simulating the welding process numerically. However, due to the complexity of the machine structure and the mutual coupling of components of the machine system...... characterizing the dynamic mechanical characteristics of resistance welding machines is suggested, and a test set-up is designed determining the basic, independent machine parameters required in the model. The model is verified by performing a series of mechanical tests as well as real projection welds......., it is very difficult to measure or calculate the basic, independent machine parameters required in a mathematical model of the machine dynamics, and no test method has so far been presented in literature, which can be applied directly in an industrial environment. In this paper, a mathematical model...
Dynamic properties of epidemic spreading on finite size complex networks
Li Ying; Liu Yang; Shan Xiu-Ming; Ren Yong; Jiao Jian; Qiu Ben
2005-01-01
The Internet presents a complex topological structure, on which computer viruses can easily spread. By using theoretical analysis and computer simulation methods, the dynamic process of disease spreading on finite size networks with complex topological structure is investigated. On the finite size networks, the spreading process of SIS (susceptibleinfected-susceptible) model is a finite Markov chain with an absorbing state. Two parameters, the survival probability and the conditional infecting probability, are introduced to describe the dynamic properties of disease spreading on finite size networks. Our results can help understanding computer virus epidemics and other spreading phenomena on communication and social networks. Also, knowledge about the dynamic character of virus spreading is helpful for adopting immunity policy.
Characterisation of Dynamic Mechanical Properties of Resistance Welding Machines
Wu, Pei; Zhang, Wenqi; Bay, Niels
2005-01-01
The dynamic mechanical properties of a resistance welding machine have significant influence on weld quality, which must be considered when simulating the welding process numerically. However, due to the complexity of the machine structure and the mutual coupling of components of the machine system......, it is very difficult to measure or calculate the basic, independent machine parameters required in a mathematical model of the machine dynamics, and no test method has so far been presented in literature, which can be applied directly in an industrial environment. In this paper, a mathematical model...... characterizing the dynamic mechanical characteristics of resistance welding machines is suggested, and a test set-up is designed determining the basic, independent machine parameters required in the model. The model is verified by performing a series of mechanical tests as well as real projection welds....
Pivovarova, E. A.; Smirnovsky, A. A.; Schmidt, A. A.
2013-11-01
Mathematical modeling of flow in the differential chamber of the gas-dynamic interface of a portable mass-spectrometer was carried out to comprehensively study the flow structure and make recommendations for the optimization of the gas-dynamic interface. Modeling was performed using an OpenFOAM open computational platform. Conditions for an optimal operating mode of the differential chamber were determined.
Dynamic properties of three-dimensional piezoelectric Kagome grids
Wu, Zhi-Jing; Li, Feng-Ming
2015-07-01
Piezoelectric Kagome grids can be considered as a kind of functional material because they have vibration isolation performance and can transform mechanical energy to electric energy. In this study, the dynamic properties of three-dimensional (3D) piezoelectric Kagome grids without and with material defects are studied based on the frequency-domain responses. The spectral element method (SEM) is adopted to solve a 3D piezoelectric beam which contains bending components in two planes, tensional components, and torsional components. The dynamic stiffness matrix of a spectral piezoelectric beam is derived. Highly accurate solutions in the frequency-domain are obtained by solving the equation of motion of the whole structure. Compared with the results from the FEM and those in the existing literature, it can be seen that the SEM can be effectively used to study the 3D piezoelectric Kagome grids. The band-gap properties of Kagome grid and defect state properties of Kagome grid with material defects are analyzed. The effect of the piezoelectric parameter on the band-gap property is investigated further.
Striking dynamics and kinetic properties of boxing and MMA gloves
Benjamin Lee
2014-08-01
Full Text Available With the growing popularity of Mixed Martial Arts (MMA as a competitive sport, questions regarding the dynamic response and properties of MMA gloves arise. High-energy impacts from punches are very similar to boxing yet MMA competition requires the use of 4 oz fingerless glove, compared to the larger full enclosure boxing glove. This work assessed the kinetic properties and strike dynamics of MMA gloves and compared findings with traditional boxing gloves. Gloves mounted on a molded fist were impacted repetitively on an instrumental anvil designed for impact, over a 5 hour period resulting in 10,000 continuous and consistent strikes. Kinetic data from impacts were sampled at the beginning of the data collection and subsequently every 30 minutes (every 1,000 strikes. MMA gloves produced 4-5 times greater peak force and 5 times faster load rate compared to the boxing glove. However, MMA gloves also showed signs of material fatigue, with peak force increasing by 35% and rate of loading increasing by 60% over the duration of the test. Boxing glove characteristics did deteriorate but to a lesser extent. In summary, the kinetic properties of MMA glove differed substantially from the boxing glove resulting in impacts characterized by higher peak forces and more rapid development of force. Material properties including stiffness and thickness play a role in the kinetic characteristics upon impact, and can be inferred to alter injury mechanisms of blunt force trauma.
Differential dynamic microscopy of weakly scattering and polydisperse protein-rich clusters.
Safari, Mohammad S; Vorontsova, Maria A; Poling-Skutvik, Ryan; Vekilov, Peter G; Conrad, Jacinta C
2015-10-01
Nanoparticle dynamics impact a wide range of biological transport processes and applications in nanomedicine and natural resource engineering. Differential dynamic microscopy (DDM) was recently developed to quantify the dynamics of submicron particles in solutions from fluctuations of intensity in optical micrographs. Differential dynamic microscopy is well established for monodisperse particle populations, but has not been applied to solutions containing weakly scattering polydisperse biological nanoparticles. Here we use bright-field DDM (BDDM) to measure the dynamics of protein-rich liquid clusters, whose size ranges from tens to hundreds of nanometers and whose total volume fraction is less than 10(-5). With solutions of two proteins, hemoglobin A and lysozyme, we evaluate the cluster diffusion coefficients from the dependence of the diffusive relaxation time on the scattering wave vector. We establish that for weakly scattering populations, an optimal thickness of the sample chamber exists at which the BDDM signal is maximized at the smallest sample volume. The average cluster diffusion coefficient measured using BDDM is consistently lower than that obtained from dynamic light scattering at a scattering angle of 90°. This apparent discrepancy is due to Mie scattering from the polydisperse cluster population, in which larger clusters preferentially scatter more light in the forward direction.
Awrejcewicz, J.; Krysko, A. V.; Pavlov, S. P.; Zhigalov, M. V.; Krysko, V. A.
2017-09-01
Chaotic dynamics of microbeams made of functionally graded materials (FGMs) is investigated in this paper based on the modified couple stress theory and von Kármán geometric nonlinearity. We assume that the beam properties are graded along the thickness direction. The influence of size-dependent and functionally graded coefficients on the vibration characteristics, scenarios of transition from regular to chaotic vibrations as well as a series of static problems with an emphasis put on the load-deflection behavior are studied. Our theoretical/numerical analysis is supported by methods of nonlinear dynamics and the qualitative theory of differential equations supplemented by Fourier and wavelet spectra, phase portraits, and Lyapunov exponents spectra estimated by different algorithms, including Wolf's, Rosenstein's, Kantz's, and neural networks. We have also detected and numerically validated a general scenario governing transition into chaotic vibrations, which follows the classical Ruelle-Takens-Newhouse scenario for the considered values of the size-dependent and grading parameters.
Criticality in conserved dynamical systems: Experimental observation vs. exact properties
Marković, Dimitrije; Gros, Claudius; Schuelein, André
2013-03-01
Conserved dynamical systems are generally considered to be critical. We study a class of critical routing models, equivalent to random maps, which can be solved rigorously in the thermodynamic limit. The information flow is conserved for these routing models and governed by cyclic attractors. We consider two classes of information flow, Markovian routing without memory and vertex routing involving a one-step routing memory. Investigating the respective cycle length distributions for complete graphs, we find log corrections to power-law scaling for the mean cycle length, as a function of the number of vertices, and a sub-polynomial growth for the overall number of cycles. When observing experimentally a real-world dynamical system one normally samples stochastically its phase space. The number and the length of the attractors are then weighted by the size of their respective basins of attraction. This situation is equivalent, for theory studies, to "on the fly" generation of the dynamical transition probabilities. For the case of vertex routing models, we find in this case power law scaling for the weighted average length of attractors, for both conserved routing models. These results show that the critical dynamical systems are generically not scale-invariant but may show power-law scaling when sampled stochastically. It is hence important to distinguish between intrinsic properties of a critical dynamical system and its behavior that one would observe when randomly probing its phase space.
Criticality in conserved dynamical systems: experimental observation vs. exact properties.
Marković, Dimitrije; Gros, Claudius; Schuelein, André
2013-03-01
Conserved dynamical systems are generally considered to be critical. We study a class of critical routing models, equivalent to random maps, which can be solved rigorously in the thermodynamic limit. The information flow is conserved for these routing models and governed by cyclic attractors. We consider two classes of information flow, Markovian routing without memory and vertex routing involving a one-step routing memory. Investigating the respective cycle length distributions for complete graphs, we find log corrections to power-law scaling for the mean cycle length, as a function of the number of vertices, and a sub-polynomial growth for the overall number of cycles. When observing experimentally a real-world dynamical system one normally samples stochastically its phase space. The number and the length of the attractors are then weighted by the size of their respective basins of attraction. This situation is equivalent, for theory studies, to "on the fly" generation of the dynamical transition probabilities. For the case of vertex routing models, we find in this case power law scaling for the weighted average length of attractors, for both conserved routing models. These results show that the critical dynamical systems are generically not scale-invariant but may show power-law scaling when sampled stochastically. It is hence important to distinguish between intrinsic properties of a critical dynamical system and its behavior that one would observe when randomly probing its phase space.
Knudstrup, Scott; Zochowski, Michal; Booth, Victoria
2016-05-01
The characteristics of neural network activity depend on intrinsic neural properties and synaptic connectivity in the network. In brain networks, both of these properties are critically affected by the type and levels of neuromodulators present. The expression of many of the most powerful neuromodulators, including acetylcholine (ACh), varies tonically and phasically with behavioural state, leading to dynamic, heterogeneous changes in intrinsic neural properties and synaptic connectivity properties. Namely, ACh significantly alters neural firing properties as measured by the phase response curve in a manner that has been shown to alter the propensity for network synchronization. The aim of this simulation study was to build an understanding of how heterogeneity in cholinergic modulation of neural firing properties and heterogeneity in synaptic connectivity affect the initiation and maintenance of synchronous network bursting in excitatory networks. We show that cells that display different levels of ACh modulation have differential roles in generating network activity: weakly modulated cells are necessary for burst initiation and provide synchronizing drive to the rest of the network, whereas strongly modulated cells provide the overall activity level necessary to sustain burst firing. By applying several quantitative measures of network activity, we further show that the existence of network bursting and its characteristics, such as burst duration and intraburst synchrony, are dependent on the fraction of cell types providing the synaptic connections in the network. These results suggest mechanisms underlying ACh modulation of brain oscillations and the modulation of seizure activity during sleep states.
Levy, Lawrence R; Yao, Weiguang; McGuire, George; Vollick, Dan N; Jette, Jennifer; Shanahan, Matthew J; Hay, James M; Neufeld, Richard W J
2012-10-01
Dynamical systems analysis is applied to a nonlinear model of stress and coping (Neufeld, 1999). The model is composed of 6 order parameters and 11 control parameters, and integrates core constructs of the topic domain, including variants of cognitive appraisal, differential stress susceptibility, stress activation, and coping propensity. In part owing to recent advances in Competitive Modes Theory (Yao, Yu & Essex, 2002), previously intractable but substantively significant dynamical properties of the 6-dimensional model are identified. They include stable and unstable fixed-point equilibria (higher-dimensional saddle-node bifurcation), oscillatory patterns attending fixed-point de-stabilization, and chaotic behaviors. Examination of the nature of system fixed-point de-stabilization, in relation to its control parameters, unveils mechanisms of re-stabilization, and dynamic stability control. All identified dynamics emerge naturally from a system whose construction guideposts are lodged in the addressed content domain. Dynamical complexities therefore may be intrinsic to the present content domain, possibly no less so than in other disciplines where the presence of such attributes has been established.
Dynamic properties of bacterial pili measured by optical tweezers
Fallman, Erik; Schedin, Staffan; Jass, Jana; Uhlin, Bernt Eric; Axner, Ove
2014-01-01
The ability of uropathogenic Escherichia coli (UPEC) to cause urinary tract infections is dependent on their ability to colonize the uroepithelium. Infecting bacteria ascend the urethra to the bladder and then kidneys by attaching to the uroepithelial cells via the differential expression of adhesins. P pili are associated with pyelonephritis, the more severe infection of the kidneys. In order to find means to treat pyelonephritis, it is therefore of interest to investigate the properties P pili. The mechanical behavior of individual P pili of uropathogenic Escherichia coli has recently been investigated using optical tweezers. P pili, whose main part constitutes the PapA rod, composed of ~1000 PapA subunits in a helical arrangement, are distributed over the bacterial surface and mediate adhesion to host cells. We have earlier studied P pili regarding its stretching/elongation properties where we have found and characterized three different elongation regions, of which one constitute an unfolding of the quate...
Calculated disturbances for evaluation of dynamical properties of freight cars
I.A. Mashchenko
2013-08-01
Full Text Available Purpose. To form realizations of the calculated disturbances for studying the dynamic properties of railway vehicles. Methodology. Records of the track-test car for one of the typical track sections of the Pridneprovsk railroad are the basic data for building the disturbance components. To derive the true geometric parameters of the railway gauge the records of the track-test car using a double-point metering circuit are transformed considering the transfer function of the measuring system. A model of the calculated disturbances is presented as the four components: a symmetric vertical irregularity determined as a semi-sum of vertical irregularities of the right and left rails; an oblique-symmetric vertical irregularity of the track determined as a semi-difference of vertical irregularities of the right and left rails; horizontal irregularities of the right and left rails. Acceptability criterion of the constructed disturbances is a relationship between the values of the dynamical properties factors of cars and the corresponding experimental data. Findings. The three techniques for the calculated disturbances forming are proposed. The first technique uses records of the track-test car for the track with a sufficiently high amount for given track conditions as components of the calculated disturbances. In so doing symmetrical vertical components of disturbances resulting from records of settling are corrected with the mass and stiffness parameters of the car under consideration. The second technique uses building and applying the theoretical realizations of irregularities corresponding to a real track according to a spectral analysis. The third technique ensures a polyharmonic model of disturbances, the parameters of which are the values of the basic frequencies and amplitudes that are typical for irregularities of a railway track. A possibility of practical applying of the constructed models of disturbances are presented using an example for
Dynamic Colour Possibilities and Functional Properties of Thermochromic Printing Inks
Rahela Kulcar
2012-07-01
Full Text Available Thermochromic printing inks change their colour regarding the change in temperature and they are one of the major groups of colour-changing inks. One of the most frequently used thermochromic material in printing inks are leuco dyes. The colour of thermochromic prints is dynamic, it is not just temperature-dependent, but it also depends on thermal history. The effect is described by colour hysteresis. This paper aims at discussing general aspects of thermochromic inks, dynamic colorimetric properties of leuco dye-based thermochromic inks, their stability and principle of variable-temperature colour measurement. Thermochromic material is protected in round-shaped capsules. They are much larger than pigments in conventional inks. The polymer envelopes of pigment capsules are more stable against oxidation than the binder. If these envelopes are damaged, the dynamic colour is irreversibly lost. Our aim is to analyse the colorimetric properties of several reversible screen-printed UV-curing leuco dye thermochromic inks with different activation temperatures printed on paper. A small analysis of irreversible thermochromic inks will be presented for comparison with reversible thermochromic inks. Moreover, so as to show interesting possibilities, a combination of different inks was made, an irreversible thermochromic ink was printed on top of the red and blue reversible thermochromic inks. Special attention was given to the characterization of colour hysteresis and the meaning of activation temperature.
Optical properties of X-rays--dynamical diffraction.
Authier, André
2012-01-01
The first attempts at measuring the optical properties of X-rays such as refraction, reflection and diffraction are described. The main ideas forming the basis of Ewald's thesis in 1912 are then summarized. The first extension of Ewald's thesis to the X-ray case is the introduction of the reciprocal lattice. In the next step, the principles of the three versions of the dynamical theory of diffraction, by Darwin, Ewald and Laue, are given. It is shown how the comparison of the dynamical and geometrical theories of diffraction led Darwin to propose his extinction theory. The main optical properties of X-ray wavefields at the Bragg incidence are then reviewed: Pendellösung, shift of the Bragg peak, fine structure of Kossel lines, standing waves, anomalous absorption, paths of wavefields inside the crystal, Borrmann fan and double refraction. Lastly, some of the modern applications of the dynamical theory are briefly outlined: X-ray topography, location of adsorbed atoms at crystal surfaces, optical devices for synchrotron radiation and X-ray interferometry.
Anastassia N. Rissanou
2015-02-01
Full Text Available Detailed atomistic (united atoms molecular dynamics simulations of several graphene based polymer (polyethylene, PE nanocomposite systems have been performed. Systems with graphene sheets of different sizes have been simulated at the same graphene concentration (~3%. In addition, a periodic graphene layer (“infinite sheet” has been studied. Results concerning structural and dynamical properties of PE chains are presented for the various systems and compared to data from a corresponding bulk system. The final properties of the material are the result of a complex effect of the graphene’s sheet size, mobility and fluctuations. A detailed investigation of density, structure and dynamics of the hybrid systems has been conducted. Particular emphasis has been given in spatial heterogeneities due to the PE/graphene interfaces, which were studied through a detailed analysis based on radial distances form the graphene’s center-of-mass. Chain segmental dynamics is found to be slower, compared to the bulk one, at the PE/graphene interface by a factor of 5 to 10. Furthermore, an analysis on the graphene sheets characteristics is presented in terms of conformational properties (i.e., wrinkling and mobility.
Stochastic dynamics of penetrable rods in one dimension: Entangled dynamics and transport properties
Craven, Galen T.; Popov, Alexander V.; Hernandez, Rigoberto, E-mail: hernandez@chemistry.gatech.edu [Center for Computational Molecular Science and Technology, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400 (United States)
2015-04-21
The dynamical properties of a system of soft rods governed by stochastic hard collisions (SHCs) have been determined over a varying range of softness using molecular dynamics simulations in one dimension and analytic theory. The SHC model allows for interpenetration of the system’s constituent particles in the simulations, generating overlapping clustering behavior analogous to the spatial structures observed in systems governed by deterministic bounded potentials. Through variation of an assigned softness parameter δ, the limiting ranges of intermolecular softness are bridged, connecting the limiting ensemble behavior from hard to ideal (completely soft). Various dynamical and structural observables are measured from simulation and compared to developed theoretical values. The spatial properties are found to be well predicted by theories developed for the deterministic penetrable-sphere model with a transformation from energetic to probabilistic arguments. While the overlapping spatial structures are complex, the dynamical properties can be adequately approximated through a theory built on impulsive interactions with Enskog corrections. Our theory suggests that as the softness of interaction is varied toward the ideal limit, correlated collision processes are less important to the energy transfer mechanism, and Markovian processes dominate the evolution of the configuration space ensemble. For interaction softness close to hard limit, collision processes are highly correlated and overlapping spatial configurations give rise to entanglement of single-particle trajectories.
Huang, Can-Ze
2015-01-01
DNA methylation, an epigenetic control mechanism in mammals, is widely present in the intestinal tract during the differentiation and proliferation of epithelial cells. Cells in stem cell pools or villi have different patterns of DNA methylation. The process of DNA methylation is dynamic and occurs at many relevant regulatory elements during the rapid transition of stem cells into fully mature, differentiated epithelial cells. Changes in DNA methylation patterns most often take place in enhancer and promoter regions and are associated with transcription factor binding. During differentiation, enhancer regions associated with genes important to enterocyte differentiation are demethylated, activating gene expression. Abnormal patterns of DNA methylation during differentiation and proliferation in the intestinal tract can lead to the formation of aberrant crypt foci and destroy the barrier and absorptive functions of the intestinal epithelium. Accumulation of these epigenetic changes may even result in tumorigenesis. In the current review, we discuss recent findings on the association between DNA methylation and cell differentiation and proliferation in the small intestine and highlight the possible links between dysregulation of this process and tumorigenesis. PMID:26413818
Jain Rupali S.
2014-12-01
Full Text Available In the present paper, we investigate the qualitative properties such as existence, uniqueness and continuous dependence on initial data of mild solutions of first and second order nonlocal semilinear functional differential equations with delay in Banach spaces. Our analysis is based on semigroup theory and modified version of Banach contraction theorem.
Investigating observability properties from data in nonlinear dynamics
Aguirre, Luis A.; Letellier, Christophe
2011-06-01
Investigation of observability properties of nonlinear dynamical systems aims at giving a hint on how much dynamical information can be retrieved from a system using a certain measuring function. Such an investigation usually requires knowledge of the system equations. This paper addresses the challenging problem of investigating observability properties of a system only from recorded data. From previous studies it is known that phase spaces reconstructed from poor observables are characterized by local sharp pleatings, local strong squeezing of trajectories, and global inhomogeneity. A statistic is then proposed to quantify such properties of poor observability. Such a statistic was computed for a number of bench models for which observability studies had been previously performed. It was found that the statistic proposed in this paper, estimated exclusively from data, correlates generally well with observability results obtained using the system equations. It is possible to arrive at the same order of observability among the state variables using the proposed statistic even in the presence of noise with a standard deviation as high as 10% of the data. The paper includes the application of the proposed statistic to sunspot time series.
Unstable normal modes of low T/W dynamical instabilities in differentially rotating stars
Saijo, Motoyuki
2016-01-01
We investigate the nature of low T/W dynamical instabilities in differentially rotating stars by means of linear perturbation. Here, T and W represent rotational kinetic energy and the gravitational binding energy of the star. This is the first attempt to investigate low T/W dynamical instabilities as a complete set of the eigenvalue problem. Our equilibrium configuration has "constant" specific angular momentum distribution, which potentially contains a singular solution in the perturbed enthalpy at corotation radius in linear perturbation. We find the unstable normal modes of differentially rotating stars by solving the eigenvalue problem along the equatorial plane of the star, imposing the regularity condition on the center and the vanished enthalpy at the oscillating equatorial surface. We find that the existing pulsation modes become unstable due to the existence of the corotation radius inside the star. The feature of the unstable mode eigenfrequency and its eigenfunction in the linear analysis roughly ...
Zhu, Jun; Yan, Xuefeng; Zhao, Weixiang
2013-10-01
To solve chemical process dynamic optimization problems, a differential evolution algorithm integrated with adaptive scheduling mutation strategy (ASDE) is proposed. According to the evolution feedback information, ASDE, with adaptive control parameters, adopts the round-robin scheduling algorithm to adaptively schedule different mutation strategies. By employing an adaptive mutation strategy and control parameters, the real-time optimal control parameters and mutation strategy are obtained to improve the optimization performance. The performance of ASDE is evaluated using a suite of 14 benchmark functions. The results demonstrate that ASDE performs better than four conventional differential evolution (DE) algorithm variants with different mutation strategies, and that the whole performance of ASDE is equivalent to a self-adaptive DE algorithm variant and better than five conventional DE algorithm variants. Furthermore, ASDE was applied to solve a typical dynamic optimization problem of a chemical process. The obtained results indicate that ASDE is a feasible and competitive optimizer for this kind of problem.
SRISAWAD; Pornrad
2010-01-01
The transverse momentum distributions of Λ’s and proton’s directed flows are investigated by using Quantum Molecular Dynamics model (QMD) within the framework of covariant kaon dynamics. The calculated results show that the transverse momentum distribution of differential directed flow of Lambda hyperons is dependent appreciably on the nuclear matter equation of states (EOS). The differential directed flow of Lambda hyperons calculated with soft EOS is consistent with the experimental data,whereas the discrepancy between the results obtained with hard EOS and experimental data increases with increasing the transverse momentum. Although the interaction acting on Λ’s by nucleons in the dense medium is attractive,the analysis indicates,that the transverse momentum distribution of proton’s directed flow is insensitive to the EOS. The results obtained with both hard and soft EOS are all roughly in agreement with the corresponding data.
An Improved Differential Evolution Based Dynamic Economic Dispatch with Nonsmooth Fuel Cost Function
R. Balamurugan
2007-09-01
Full Text Available Dynamic economic dispatch (DED is one of the major operational decisions in electric power systems. DED problem is an optimization problem with an objective to determine the optimal combination of power outputs for all generating units over a certain period of time in order to minimize the total fuel cost while satisfying dynamic operational constraints and load demand in each interval. This paper presents an improved differential evolution (IDE method to solve the DED problem of generating units considering valve-point effects. Heuristic crossover technique and gene swap operator are introduced in the proposed approach to improve the convergence characteristic of the differential evolution (DE algorithm. To illustrate the effectiveness of the proposed approach, two test systems consisting of five and ten generating units have been considered. The results obtained through the proposed method are compared with those reported in the literature.
Temporal Dynamics of Connectivity and Epidemic Properties of Growing Networks
Fotouhi, Babak
2015-01-01
Traditional mathematical models of epidemic disease had for decades conventionally considered static structure for contacts. Recently, an upsurge of theoretical inquiry has strived towards rendering the models more realistic by incorporating the temporal aspects of networks of contacts, societal and online, that are of interest in the study of epidemics (and other similar diffusion processes). However, temporal dynamics have predominantly focused on link fluctuations and nodal activities, and less attention has been paid to the growth of the underlying network. Many real networks grow: online networks are evidently in constant growth, and societal networks can grow due to migration flux and reproduction. The effect of network growth on the epidemic properties of networks is hitherto unknown---mainly due to the predominant focus of the network growth literature on the so-called steady-state. This paper takes a step towards alleviating this gap. We analytically study the degree dynamics of a given arbitrary net...
Recurrence properties of quantum observables in wave packet dynamics
Sudheesh, C; Balakrishnan, V
2009-01-01
We investigate the recurrence properties of the time series of quantum mechanical expectation values, in terms of two representative models for a single-mode radiation field interacting with a nonlinear medium. From recurrence-time distributions, return maps and recurrence plots, we conclude that the dynamics of appropriate observables pertaining to the field can vary from quasiperiodicity to hyperbolicity, depending on the extent of the nonlinearity and of the departure from coherence of the initial state of the field. We establish that, in a simple bipartite model in which the field is effectively an open quantum system, a decaying exponential recurrence-time distribution, characteristic of a hyperbolic dynamical system, is associated with chaotic temporal evolution as characterized by a positive Liapunov exponent.
KINEMATIC WAVE PROPERTIES OF ANISOTROPIC DYNAMICS MODEL FOR TRAFFIC FLOW
姜锐; 吴清松; 朱祚金
2002-01-01
The analyses of kinematic wave properties of a new dynamics model for traffic flow are carried out. The model does not exhibit the problem that one characteristic speed is always greater than macroscopic traffic speed, and therefore satisfies the requirement that traffic flow is anisotropic. Linear stability analysis shows that the model is stable under certain condition and the condition is obtained. The analyses also indicate that the model has a hierarchy of first-and second-order waves, and allows the existence of both smooth traveling wave and shock wave. However, the model has a distinctive criterion of shock wave compared with other dynamics models, and the distinction makes the model more realistic in dealing with some traffic problems such as wrong-way travel analysis.
PROPERTIES OF PROLIFERATION AND DIFFERENTIATION OF NEONATAL RAT RETINAL PROGENITOR CELLS IN VITRO
Kang Qianyan; Liu Yong; Zhao Jianjun; Qiu Fen; Chen Xinlin; Tian Yumei; Hu Ming
2006-01-01
Objective To investigate the properties of proliferation and differentiation of neonatal rat retinal progenitor cells (RPCs) in vitro. Methods RPCs were isolated from neonatal SD rats neural retina and cultured in DMEM/F12+N2 with EGF and bFGF (suspension medium )or 10%FBS without EGF and bFGF (differentiation medium). The cells grew as suspended spheres or adherent monolayers, depending on different culture conditions. The neural stem cells or retinal progenitors, neurons, astrocytes, retinal ganglion cells, rod photoreceptors and the proliferating cells were evaluated with immunofluorescence analysis by Nestin or Pax6, Map2, GFAP, Thy-1, Rhodopsin and BrdU antibodies respectively. Results RPCs could propagate and differentiate in suspension or differentiation medium and express the markers of Nestin (92.86%) or Pax6 (86.75%), Map2 (38.54%), GFAP (20.93%), Thy-1 (27.66%) and Rhodopsin(13.33%)in suspension medium; however, Nestin (60.27%), Pax6 (52%), Map2 (34.94%), GFAP (38.17%), Thy-1(30.84%) and Rhodopsin (34.67%) in differentiation medium. 96.4% of the population in the neurospheres was BrdU-positive cells. The cells could spontaneously adherent forming some subspheres and retinal specific cell types. Conclusion Neonatal rat RPCs possess the high degree of proliferation and can differentiate into neurons, astrocytes, retinal ganglion cells and rod photoreceptors in vitro. There are different proportions for RPCs to differentiate into specific cell types.
Shaolin Ji
2013-01-01
Full Text Available This paper is devoted to a stochastic differential game (SDG of decoupled functional forward-backward stochastic differential equation (FBSDE. For our SDG, the associated upper and lower value functions of the SDG are defined through the solution of controlled functional backward stochastic differential equations (BSDEs. Applying the Girsanov transformation method introduced by Buckdahn and Li (2008, the upper and the lower value functions are shown to be deterministic. We also generalize the Hamilton-Jacobi-Bellman-Isaacs (HJBI equations to the path-dependent ones. By establishing the dynamic programming principal (DPP, we derive that the upper and the lower value functions are the viscosity solutions of the corresponding upper and the lower path-dependent HJBI equations, respectively.
Periodic solutions of first-order functional differential equations in population dynamics
Padhi, Seshadev; Srinivasu, P D N
2014-01-01
This book provides cutting-edge results on the existence of multiple positive periodic solutions of first-order functional differential equations. It demonstrates how the Leggett-Williams fixed-point theorem can be applied to study the existence of two or three positive periodic solutions of functional differential equations with real-world applications, particularly with regard to the Lasota-Wazewska model, the Hematopoiesis model, the Nicholsons Blowflies model, and some models with Allee effects. Many interesting sufficient conditions are given for the dynamics that include nonlinear characteristics exhibited by population models. The last chapter provides results related to the global appeal of solutions to the models considered in the earlier chapters. The techniques used in this book can be easily understood by anyone with a basic knowledge of analysis. This book offers a valuable reference guide for students and researchers in the field of differential equations with applications to biology, ecology, a...
Sun, Peng; You, Feng; Liu, Mengxia; Wu, Zhihao; Wen, Aiyun; Li, Jun; Xu, Yongli; Zhang, Peijun
2010-03-01
Steroid sex hormones, such as estradiol-17β (E2) and testosterone (T), are important regulators of sex change in fish. In this study, we examined the effects of E2 treatment on the dynamics of E2 and T during gonadal differentiation in the olive flounder Paralichthys olivaceus using histology and radioimmunoassay (RIA). Flounder larvae were divided into five groups (G0-G4), and fed with 0 (control), 0.2, 2, 20 and 100 mg E2/kg feed from 35 to 110 day post hatching (dph). Fish growth in the G1 and G2 groups was not significantly different from that of the control group ( P>0.05), while fish in the G3 and G4 groups were less active and showed growth depression and high mortality. The gonads of fish in the G3 and G4 groups were smaller and surrounded by hyperplastic connective tissue. The frequency of females in the G0-G4 groups was 54.5%, 75.0%, 100%, 100% and 93.3%, respectively. The RIA analyses of E2 and T showed that T levels decreased during gonadal differentiation, and increased slightly at the onset of ovarian differentiation, while E2 levels increased gradually and peaked at the onset of ovarian differentiation in the control group. In the E2-treated groups, T levels decreased before the onset of ovarian differentiation. E2 levels were high on the 48 dph, but declined to a lower level on the 54 dph, and then increased gradually during gonadal differentiation. And a sharp increase of E2 levels were observed in all E2-treated groups at the onset of ovarian differentiation. The data suggest that T and E2 play important roles during gonadal differentiation, and an E2 dose of 2 mg/kg feed could induce sex reversal in P. olivaceus.
Cao Hong-qing; Kang Li-shan; Yu Jing-xian
2003-01-01
First, an asynchronous distributed parallel evolutionary modeling algorithm (PEMA) for building the model of system of ordinary differential equations for dynamical systems is proposed in this paper. Then a series of parallel experiments have been conducted to systematically test the influence of some important parallel control parameters on the performance of the algorithm. A lot of experimental results are obtained and we make some analysis and explanations to them.
Dynamic properties and time response of frameworks with semi-rigid and eccentric connections
Gopčević Špiro
2011-01-01
Full Text Available The paper is considering effects of the semi-rigid and eccentric joint connections of framework structures upon its dynamic properties and the time response due to an earthquake action. The corresponding numerical method representing the linear structural behavior is developed. Semi-rigid connections at beam ends are presented by the rotational springs at beam's ends, with linear moment-rotation relationship. Eccentricity of joint connections is presented by the corresponding short infinitely rigid links at beam's ends. The effect of semi-rigid and eccentric connections is introduced in the numerical model by the corresponding corrective matrix. The corrective matrix is applied upon the conventional stiffness matrix of the beam element with usual rigid and centric connections. As important dynamic properties, the change of the natural circular frequencies and the natural modes, due to variation of joint rigidity and eccentricity of beam-to-column connections, is analyzed. In the time response structural analysis, considering displacements only, dynamic loading due to an earthquake defined by a given accelerogram is considered. The solution of the differential equations of motion is obtained by direct numerical step-by-step integration using the α method (Hilber-Hughes- Taylor. In order to perform the numerical analysis, all considered numerical models and methods are implemented into the corresponding computer code, called ELAN, which is then used for the parametric analyses presented in the paper.
Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung
Ohno, Yoshiharu E-mail: yosirad@kobe-u.ac.jpyosirad@med.kobe-u.ac.jpyoshiharuohno@aol.com; Hatabu, Hiroto; Takenaka, Daisuke; Uematsu, Hidemasa; Ohbayashi, Chiho; Higashino, Takanori; Nogami, Munenobu; Yoshimura, Masahiro; Fujii, Masahiko; Sugimura, Kazuro
2004-11-01
Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung. Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20 mm in diameter) underwent dynamic contrast-enhanced MRI. Maximum relative enhancement ratio, slope of enhancement, and corrected start time of enhancement were calculated from signal intensity-time curve of pulmonary lesion for each subject, and were statistically compared among bronchioloalveolar carcinoma (BAC) group (7 cases), mixed BAC group (10 cases), and adenocarcinoma group (12 cases). Results: Maximum relative enhancement ratio (P<0.001) and slope of enhancement (P<0.001) of BAC group were significantly higher than those of mixed BAC and adenocarcinoma groups. Start times of BAC group were significantly earlier than those of mixed BAC (P=0.0001) and adenocarcinoma groups (P<0.0001). Adapting the thresholds values of MR indexes from the positive tests, sensitivity, specificity, positive predictive value, negative predictive value and accuracy for differentiating BAC from other subtypes were 85.7, 100.0, 100.0, 95.7, and 96.6%, respectively. Conclusions: Dynamic MRI is useful for differentiating subtypes of small peripheral adenocarcinoma.
Dynamic response of a vehicle with planar suspension system (PSS) under differential braking
Zhu, Jian Jun; Khajepour, Amir; Esmailzadeh, Ebrahim
2012-01-01
To absorb the vibrations and shocks caused by road obstacles effectively in any direction within the wheel rotation plane, a planar suspension system (PSS), in which there are spring-damper struts in both the vertical and longitudinal directions, is proposed to improve the ride quality of a vehicle with such novel suspension systems. The longitudinal spring-damper strut in a PSS is considerably soft compared with the longitudinal connection in a conventional suspension. Consequently, the wheels in a vehicle with PSS can move forth and back with respect to the body. The dynamic behaviours of a PSS vehicle under some special conditions, such as a differential braking in which the braking torque applied to the wheels at two sides of an axle are uneven, may exhibit special characteristics. The directional stability of the PSS vehicle in such a case may be one of the major concerns. The dynamic performance of the PSS vehicle in the differential braking condition is thus necessary to be investigated. This paper presents the investigation results of the transient response of a vehicle with the PSS in such a case. The simulation results are also compared with those of a similar vehicle with conventional suspensions. The study demonstrates that the PSS vehicle is directionally stable in differential braking conditions. The dynamic behaviour of the PSS vehicle is generally comparable with that of a conventional vehicle.
Fu Freddie H
2011-06-01
Full Text Available Abstract Background The human anterior cruciate ligament (hACL and medial collateral ligament (hMCL of the knee joint are frequently injured, especially in athletic settings. It has been known that, while injuries to the MCL typically heal with conservative treatment, ACL injuries usually do not heal. As adult stem cells repair injured tissues through proliferation and differentiation, we hypothesized that the hACL and hMCL contain stem cells exhibiting unique properties that could be responsible for the differential healing capacity of the two ligaments. Methods To test the above hypothesis, we derived ligament stem cells from normal hACL and hMCL samples from the same adult donors using tissue culture techniques and characterized their properties using immunocytochemistry, RT-PCR, and flow cytometry. Results We found that both hACL stem cells (hACL-SCs and hMCL stem cells (hMCL-SCs formed colonies in culture and expressed stem cell markers nucleostemin and stage-specific embryonic antigen-4 (SSEA-4. Moreover, both hACL-SCs and hMCL-SCs expressed CD surface markers for mesenchymal stem cells, including CD44 and CD90, but not those markers for vascular cells, CD31, CD34, CD45, and CD146. However, hACL-SCs differed from hMCL-SCs in that the size and number of hACL-SC colonies in culture were much smaller and grew more slowly than hMCL-SC colonies. Moreover, fewer hACL-SCs in cell colonies expressed stem cell markers STRO-1 and octamer-binding transcription factor-4 (Oct-4 than hMCL-SCs. Finally, hACL-SCs had less multi-differentiation potential than hMCL-SCs, evidenced by differing extents of adipogenesis, chondrogenesis, and osteogenesis in the respective induction media. Conclusions This study shows for the first time that hACL-SCs are intrinsically different from hMCL-SCs. We suggest that the differences in their properties contribute to the known disparity in healing capabilities between the two ligaments.
Static and dynamic properties of KCNCl1−
Jyotsna Galgale; Nupinder Kaur; Preeti Singh; Manik Manake; N K Gaur; R K Singh
2004-08-01
An extended three-body force shell model (ETSM) has been applied to investigate the static and dynamic properties of KCNCl1− for the composition = 0.56 and 1.0 at 300 K. The phonon dispersion curves computed by us are compared with the single crystal neutron diffraction data. The unusual features of these curves are the upward curvature seen in some of the acoustic branches. This is a result of -dependent softening of the phonon due to translation–rotation coupling. The transverse acoustic branch is more soft near the zone centre.
Analytic results for oscillatory systems with extremal dynamic properties
Górecki Henryk
2014-12-01
Full Text Available The maximal value of the error is the most important criterion in system design. It is also the most difficult one. For that reason there exist many other criteria. The extreme value of the error represents the attainable accuracy which can be obtained and the corresponding extreme time gives information about how fast the transients are. The extreme values of the error and the corresponding time are treated here as functions of the roots of the characteristic equation. The proposed analytical formulae allow designing systems with prescribed dynamic properties.
World-trade web: Topological properties, dynamics, and evolution
Fagiolo, Giorgio; Reyes, Javier; Schiavo, Stefano
2009-03-01
This paper studies the statistical properties of the web of import-export relationships among world countries using a weighted-network approach. We analyze how the distributions of the most important network statistics measuring connectivity, assortativity, clustering, and centrality have coevolved over time. We show that all node-statistic distributions and their correlation structure have remained surprisingly stable in the last 20years —and are likely to do so in the future. Conversely, the distribution of (positive) link weights is slowly moving from a log-normal density towards a power law. We also characterize the autoregressive properties of network-statistics dynamics. We find that network-statistics growth rates are well-proxied by fat-tailed densities like the Laplace or the asymmetric exponential power. Finally, we find that all our results are reasonably robust to a few alternative, economically meaningful, weighting schemes.
Dynamic compressive properties of bovine knee layered tissue
Nishida, Masahiro; Hino, Yuki; Todo, Mitsugu
2015-09-01
In Japan, the most common articular disease is knee osteoarthritis. Among many treatment methodologies, tissue engineering and regenerative medicine have recently received a lot of attention. In this field, cells and scaffolds are important, both ex vivo and in vivo. From the viewpoint of effective treatment, in addition to histological features, the compatibility of mechanical properties is also important. In this study, the dynamic and static compressive properties of bovine articular cartilage-cancellous bone layered tissue were measured using a universal testing machine and a split Hopkinson pressure bar method. The compressive behaviors of bovine articular cartilage-cancellous bone layered tissue were examined. The effects of strain rate on the maximum stress and the slope of stress-strain curves of the bovine articular cartilage-cancellous bone layered tissue were discussed.
Static and Dynamical Properties of heavy actinide Monopnictides of Lutetium
Mir, Showkat H.; Jha, Prakash C.; Islam, M. S.; Banarjee, Amitava; Luo, Wei; Dabhi, Shweta D.; Jha, Prafulla K.; Ahuja, R.
2016-07-01
In this work, density functional theory within the framework of generalized gradient approximation has been used to investigate the structural, elastic, mechanical, and phonon properties of lutetium monopnictides in rock-salt crystal structure. The spin orbit coupling and Hubbard-U corrections are included to correctly predict the essential properties of these compounds. The elastic constants, Young’s modulus E, Poisson’s ratio v, shear modulus G, anisotropy factor A and Pugh’s ratio are computed. We found that all lutetium monopnictides are anisotropic and show brittle character. From the wave velocities along [100], [110] and [111] directions, melting temperature of lutetium monopnictides are predicted. Dynamical stability of these monopnictides has been studied by density functional perturbation theory.
Dynamic Mechanical Properties of Bio-Polymer Graphite Thin Films
Saddam Kamarudin, M.; Rus, Anika Zafiah M.; Munirah Abdullah, Nur; Abdullah, M. F. L.
2017-08-01
Waste cooking oil is used as the main substances in producing graphite biopolymer thin films. Biopolymer is produce from the reaction of bio-monomer and cross linker with the ratio of 2:1 and addition of graphite with an increment of 2% through a slip casting method. The morphological surface properties of the samples are observed by using Scanning Electron Microscope (SEM). It is shown that the graphite particle is well mixed and homogenously dispersed in biopolymer matrix. Meanwhile, the mechanical response of materials by monitoring the change in the material properties in terms of frequency and temperature of the samples were determined using Dynamic Mechanical Analysis (DMA). The calculated cross-linked density of biopolymer composites revealed the increment of graphite particle loading at 8% gives highest results with 260.012 x 103 M/m3.
Optical properties and electron dynamics in carbon nanodots
Wen, Xiaoming; Huang, Shujuan; Conibeer, Gavin; Shrestha, Santosh; Yu, Pyng; Toh, Yon-Rui; Tang, Jau
2013-12-01
Carbon nanodots (CNDs) have emerged as fascinating materials with exceptional electronic and optical properties, and thus they offer promising applications in photonics, photovoltaics and photocatalysis. Herein we study the optical properties and electron dynamics in CNDs using steady state and time-resolved spectroscopy. The photoluminescence (PL) is determined to originate from both core and surface. The massive surface fluorophores result in a broad spectral fluorescence. In addition to various synthesis techniques, it is demonstrated that the PL of CNDs can be extended from the blue to the near infrared by thermal assisted growth. Directional electron transfer was observed as fast as femtosecond in CND-graphene oxide nanocomposites from CND into graphene oxide. These results suggest CNDs can be promising in many applications.
Tuning Properties and Dynamic Range of Type 1 Vomeronasal Receptors
Sachiko eHaga-Yamanaka
2015-07-01
Full Text Available The mouse vomeronasal organ expresses chemosensory receptors that detect intra-species as well as inter-species cues. The vomeronasal neurons are thought to be highly selective in their responses. The tuning properties of individual receptors remain difficult to characterize due to the lack of a robust heterologous expression system. Here, we take a transgenic approach to ectopically express two Type 1 vomeronasal receptors in the mouse vomeronasal organ and characterize their responses to steroid compounds. We find that V1rj2 and V1rj3 are sensitive to two sulfated estrogens and can be activated by a broad variety of sulfated and glucuronidated steroids at high concentrations. Individual neurons exhibit narrow range of concentration-dependent activation. Collectively, a neuronal population expressing the same receptor covers a wide dynamic range in their responses to sulfated estrogens. These properties recapitulate the response profiles of endogenous neurons to sulfated estrogens.
Tuning properties and dynamic range of type 1 vomeronasal receptors
Haga-Yamanaka, Sachiko; Ma, Limei; Yu, C. Ron
2015-01-01
The mouse vomeronasal organ (VNO) expresses chemosensory receptors that detect intra-species as well as inter-species cues. The vomeronasal neurons are thought to be highly selective in their responses. The tuning properties of individual receptors remain difficult to characterize due to the lack of a robust heterologous expression system. Here, we take a transgenic approach to ectopically express two type 1 vomeronasal receptors in the mouse VNO and characterize their responses to steroid compounds. We find that V1rj2 and V1rj3 are sensitive to two sulfated estrogens (SEs) and can be activated by a broad variety of sulfated and glucuronidated steroids at high concentrations. Individual neurons exhibit narrow range of concentration-dependent activation. Collectively, a neuronal population expressing the same receptor covers a wide dynamic range in their responses to SEs. These properties recapitulate the response profiles of endogenous neurons to SEs. PMID:26236183
Kersti Jääger
Full Text Available BACKGROUND: Tissue regeneration and recovery in the adult body depends on self-renewal and differentiation of stem and progenitor cells. Mesenchymal stem cells (MSCs that have the ability to differentiate into various cell types, have been isolated from the stromal fraction of virtually all tissues. However, little is known about the true identity of MSCs. MSC populations exhibit great tissue-, location- and patient-specific variation in gene expression and are heterogeneous in cell composition. METHODOLOGY/PRINCIPAL FINDINGS: Our aim was to analyze the dynamics of differentiation of two closely related stromal cell types, adipose tissue-derived MSCs (AdMSCs and dermal fibroblasts (FBs along adipogenic, osteogenic and chondrogenic lineages using multiplex RNA-seq technology. We found that undifferentiated donor-matched AdMSCs and FBs are distinct populations that stay different upon differentiation into adipocytes, osteoblasts and chondrocytes. The changes in lineage-specific gene expression occur early in differentiation and persist over time in both AdMSCs and FBs. Further, AdMSCs and FBs exhibit similar dynamics of adipogenic and osteogenic differentiation but different dynamics of chondrogenic differentiation. CONCLUSIONS/SIGNIFICANCE: Our findings suggest that stromal stem cells including AdMSCs and dermal FBs exploit different molecular mechanisms of differentiation to reach a common cell fate. The early mechanisms of differentiation are lineage-specific and are similar for adipogenic and osteogenic differentiation but are distinct for chondrogenic differentiation between AdMSCs and FBs.
Jääger, Kersti; Islam, Saiful; Zajac, Pawel; Linnarsson, Sten; Neuman, Toomas
2012-01-01
Background Tissue regeneration and recovery in the adult body depends on self-renewal and differentiation of stem and progenitor cells. Mesenchymal stem cells (MSCs) that have the ability to differentiate into various cell types, have been isolated from the stromal fraction of virtually all tissues. However, little is known about the true identity of MSCs. MSC populations exhibit great tissue-, location- and patient-specific variation in gene expression and are heterogeneous in cell composition. Methodology/Principal Findings Our aim was to analyze the dynamics of differentiation of two closely related stromal cell types, adipose tissue-derived MSCs (AdMSCs) and dermal fibroblasts (FBs) along adipogenic, osteogenic and chondrogenic lineages using multiplex RNA-seq technology. We found that undifferentiated donor-matched AdMSCs and FBs are distinct populations that stay different upon differentiation into adipocytes, osteoblasts and chondrocytes. The changes in lineage-specific gene expression occur early in differentiation and persist over time in both AdMSCs and FBs. Further, AdMSCs and FBs exhibit similar dynamics of adipogenic and osteogenic differentiation but different dynamics of chondrogenic differentiation. Conclusions/Significance Our findings suggest that stromal stem cells including AdMSCs and dermal FBs exploit different molecular mechanisms of differentiation to reach a common cell fate. The early mechanisms of differentiation are lineage-specific and are similar for adipogenic and osteogenic differentiation but are distinct for chondrogenic differentiation between AdMSCs and FBs. PMID:22723894
Requirements for dynamical differential phase contrast x-ray imaging with a laboratory source
Macindoe, David; Kitchen, Marcus J.; Irvine, Sarah C.; Fouras, Andreas; Morgan, Kaye S.
2016-12-01
X-ray phase contrast enables weakly-attenuating structures to be imaged, with bright synchrotron sources adding the ability to capture time sequences and analyse sample dynamics. Here, we describe the translation of dynamical differential phase contrast imaging from the synchrotron to a compact x-ray source, in order to achieve this kind of time sequence imaging in the laboratory. We formulate broadly-applicable set-up guidelines for the single-grid, single-exposure imaging technique using a divergent source, exploring the experimental factors that restrict set-up size, imaging sensitivity and sample size. Experimental images are presented using the single-grid phase contrast technique with a steel attenuation grid and a liquid-metal-jet x-ray source, enabling exposure times as short as 0.5 s for dynamic imaging. Differential phase contrast images were retrieved from phantoms, incorporating noise filtering to improve the low-count images encountered when imaging dynamics using short exposures.
A review of linear response theory for general differentiable dynamical systems
Ruelle, David
2009-04-01
The classical theory of linear response applies to statistical mechanics close to equilibrium. Away from equilibrium, one may describe the microscopic time evolution by a general differentiable dynamical system, identify nonequilibrium steady states (NESS) and study how these vary under perturbations of the dynamics. Remarkably, it turns out that for uniformly hyperbolic dynamical systems (those satisfying the 'chaotic hypothesis'), the linear response away from equilibrium is very similar to the linear response close to equilibrium: the Kramers-Kronig dispersion relations hold, and the fluctuation-dispersion theorem survives in a modified form (which takes into account the oscillations around the 'attractor' corresponding to the NESS). If the chaotic hypothesis does not hold, two new phenomena may arise. The first is a violation of linear response in the sense that the NESS does not depend differentiably on parameters (but this nondifferentiability may be hard to see experimentally). The second phenomenon is a violation of the dispersion relations: the susceptibility has singularities in the upper half complex plane. These 'acausal' singularities are actually due to 'energy nonconservation': for a small periodic perturbation of the system, the amplitude of the linear response is arbitrarily large. This means that the NESS of the dynamical system under study is not 'inert' but can give energy to the outside world. An 'active' NESS of this sort is very different from an equilibrium state, and it would be interesting to see what happens for active states to the Gallavotti-Cohen fluctuation theorem.
Cianfrini Marta
2015-01-01
Full Text Available Laminar natural convection of Al2O3 + H2O nanofluids inside square cavities differentially heated at sides is studied numerically. A computational code based on the SIMPLE-C algorithm is used for the solution of the system of the mass, momentum and energy transfer governing equations. Assuming that the nanofluid behaves like a single-phase fluid, these equations are the same as those valid for a pure fluid, provided that the thermophysical properties appearing in them are the nanofluid effective properties. The thermal conductivity and dynamic viscosity of the nanofluid are calculated by means of a couple of empirical equations based on a wide variety of experimental data reported in the literature. The other effective properties are evaluated by the conventional mixing theory. Simulations are performed for different values of the nanoparticle volume fraction in the range 0-0.06, the diameter of the suspended nanoparticles in the range 25-100 nm, the temperature of the cooled sidewall in the range 293-313 K, the temperature of the heated sidewall in the range 298-343 K, and the Rayleigh number of the base fluid in the range 103-107. All computations are executed in the hypothesis of temperature-dependent effective properties. The main result obtained is the existence of an optimal particle loading for maximum heat transfer, that is found to increase as the size of the suspended nanoparticles is decreased, and the nanofluid average temperature is increased.
Luo, Yi; Yu, Jianqun; Chen, Dongdong; Xu, Zhongzi; Zeng, Hanjiang
2013-12-01
We studied the actions of diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) in differentiating breast tumors. From January 2010 to February 2012, we retrospectively analyzed data of 95 cases with breast tumor pathologically confirmed from DWI and DCE-MRI. We compared the ADC value, time-intensity curve (TIC) and DCE-MRI parameters between breast tumors, and calculated the sensitivity and specificity for differentiating breast tumors. The results were as follows: (1) On DWI, mean ADC value of malignant tumor was lower than that of benign tumor (P value of time to peak (Tpeak) and maximal enhancement ratio (SImax) were lower than that of benign tumor (all P < 0.05). As for TIC, type II and III were more frequently seen in malignant tumor than in benign tumor whereas type I was more common in benign tumor than in malignant tumor (all P < 0.05). For differentiating breast malignant tumors from benign neoplasm, DCE-MRI obtained a sensitivity of 89.7% and specificity of 70.3%. (3) For differentiating breast malignant tumors from benign neoplasm, ADC value together with TIC obtained a sensitivity of 79.3% and specificity of 78.4%. Malignant or benign breast tumors could have their own unique characteristics on DWI and DCE-MRI. These characteristics might be helpful for differentiating these tumors.
Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation
Kesavan, Gokul; Lieven, Oliver; Mamidi, Anant; Öhlin, Zarah Löf; Johansson, Jenny Kristina; Li, Wan-Chun; Lommel, Silvia; Greiner, Thomas Uwe; Semb, Henrik
2014-01-01
Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination and epithelial cell movement within the plane of an epithelium are associated with a change in cellular phenotype. However, how this positional change is linked to differentiation remains unknown. Using the developing mouse pancreas as a model system, we show that β cell delamination and differentiation are two independent events, which are controlled by Cdc42/N-WASP signaling. Specifically, we show that expression of constitutively active Cdc42 in β cells inhibits β cell delamination and differentiation. These processes are normally associated with junctional actin and cell-cell junction disassembly and the expression of fate-determining transcription factors, such as Isl1 and MafA. Mechanistically, we demonstrate that genetic ablation of N-WASP in β cells expressing constitutively active Cdc42 partially restores both delamination and β cell differentiation. These findings elucidate how junctional actin dynamics via Cdc42/N-WASP signaling cell-autonomously control not only epithelial delamination but also cell differentiation during mammalian organogenesis. PMID:24449844
Ratna Juwita
2013-04-01
Full Text Available Cell membranes are composed mainly of phospholipids which are in turn, composed of five major chemical elements: carbon, hydrogen, nitrogen, oxygen, and phosphorus. Recent studies have suggested the possibility of sustaining life if the phosphorus is substituted by arsenic. Although this issue is still controversial, it is of interest to investigate the properties of arsenated-lipid bilayers to evaluate this possibility. In this study, we simulated arsenated-lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-arsenocholine (POAC, lipid bilayers using all-atom molecular dynamics to understand basic structural and dynamical properties, in particular, the differences from analogous 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, (POPC lipid bilayers. Our simulations showed that POAC lipid bilayers have distinct structural and dynamical properties from those of native POPC lipid bilayers. Relative to POPC lipid bilayers, POAC lipid bilayers have a more compact structure with smaller lateral areas and greater order. The compact structure of POAC lipid bilayers is due to the fact that more inter-lipid salt bridges are formed with arsenate-choline compared to the phosphate-choline of POPC lipid bilayers. These inter-lipid salt bridges bind POAC lipids together and also slow down the head group rotation and lateral diffusion of POAC lipids. Thus, it would be anticipated that POAC and POPC lipid bilayers would have different biological implications.
Spin Dynamics simulations of the dynamic properties of classical models for magnetic materials
Bunker, Alex; Landau, D. P.
1998-03-01
The Spin Dynamics simulation technique, which has had considerable success for the study of critical properties of classical Heisenberg antiferromagnets(A. Bunker, K. Chen, and D. P. Landau Phys. Rev. B) \\underline54, 9259 (1996), has been used to determine more general properties for a wider range of materials. A general spin dynamics program has been developed which can determine the dynamic structure factor, S(q,ω), in the [100], [110], and [111] directions for a wide range of classical magnetic models at any temperature desired. We have simulated the magnetic dynamics in the ordered phase of the isotropic Heisenberg model with both ferromagnetic and antiferromagnetic coupling on L×L×L BCC and SC lattices. Outside of the critical regime relatively small lattice sizes of L = 12, 24 could be used. From our simulation we have determined the stiffness coefficient and the spin relaxation rate which were compared to both experimental(J. Als-Nielsen in Phase Transitions and Critical Phenomena), ed. C. Domb, M. S. Green, Academic Press, (1976) and theoretical results. We have performed the same simulation with anisotropy appropriate for MnF2 and FeF_2. Research supported in part by the NSF
Ah-Reum eKo
2016-05-01
Full Text Available The response and susceptibility to astroglial degenerations are relevant to the distinctive properties of astrocytes in a hemodynamic-independent manner following status epilepticus (SE.Since impaired mitochondrial fission plays an important role in mitosis, apoptosis and programmed necrosis, we investigated whether the unique pattern of mitochondrial dynamics is involved in the characteristics of astroglial death induced by SE. In the present study, SE induced astroglial apoptosis in the molecular layer of the dentate gyrus, accompanied by decreased mitochondrial length. In contrast, clasmatodendritic (autophagic astrocytes in the CA1 region showed mitochondrial elongation induced by SE. Mdivi-1 (an inhibitor of mitochondrial fission effectively attenuated astroglial apoptosis, but WY14643 (an enhancer of mitochondrial fissionaggravated it. In addition, Mdivi-1accelerated clasmatodendritic changes in astrocytes. These regional specific mitochondrial dynamics in astrocytes were closely correlated with dynamin-related protein (DRP1, a mitochondrial fission protein phosphorylation, not optic atrophy 1 (a mitochondrial fusion protein expression. To the best of our knowledge, the present data demonstrate for the first time the novel role of DRP1-mediated mitochondrial fission in astroglial loss. Thus, the present findings suggest that the differential astroglial mitochondrial dynamics may participate in the distinct characteristics of astroglial death induced by SE.
Forn, Marta; Díez-Villanueva, Anna; Merlos-Suárez, Anna; Muñoz, Mar; Lois, Sergi; Carriò, Elvira; Jordà, Mireia; Bigas, Anna; Batlle, Eduard; Peinado, Miguel A.
2015-01-01
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. To get insights into the dynamics of cell differentiation and malignant transformation we have compared the DNA methylation profiles along the mouse small intestine crypt and early stages of tumorigenesis. Genome-scale analysis of DNA methylation together with microarray gene expression have been applied to compare intestinal crypt stem cells (EphB2high), differentiated cells (EphB2negative), ApcMin/+ adenomas and the corresponding non-tumor adjacent tissue, together with small and large intestine samples and the colon cancer cell line CT26. Compared with late stages, small intestine crypt differentiation and early stages of tumorigenesis display few and relatively small changes in DNA methylation. Hypermethylated loci are largely shared by the two processes and affect the proximities of promoter and enhancer regions, with enrichment in genes associated with the intestinal stem cell signature and the PRC2 complex. The hypermethylation is progressive, with minute levels in differentiated cells, as compared with intestinal stem cells, and reaching full methylation in advanced stages. Hypomethylation shows different signatures in differentiation and cancer and is already present in the non-tumor tissue adjacent to the adenomas in ApcMin/+ mice, but at lower levels than advanced cancers. This study provides a reference framework to decipher the mechanisms driving mouse intestinal tumorigenesis and also the human counterpart. PMID:25933092
Raymon, H K; Thode, S; Zhou, J; Friedman, G C; Pardinas, J R; Barrere, C; Johnson, R M; Sah, D W
1999-07-01
A renewable source of human sensory neurons would greatly facilitate basic research and drug development. We had established previously conditionally immortalized human CNS cell lines that can differentiate into functional neurons (). We report here the development of an immortalized human dorsal root ganglion (DRG) clonal cell line, HD10.6, with a tetracycline-regulatable v-myc oncogene. In the proliferative condition, HD10.6 cells have a doubling time of 1.2 d and exhibit a neuronal precursor morphology. After differentiation of clone HD10.6 for 7 d in the presence of tetracycline, v-myc expression was suppressed, and >50% of the cells exhibited typical neuronal morphology, stained positively for neuronal cytoskeletal markers, and fired action potentials in response to current injection. Furthermore, this cell line was fate-restricted to a neuronal phenotype; even in culture conditions that promote Schwann cell or smooth muscle differentiation of neural crest stem cells, HD10.6 differentiated exclusively into neurons. Moreover, differentiated HD10.6 cells expressed sensory neuron-associated transcription factors and exhibited capsaicin sensitivity. Taken together, these data indicate that we have established an immortalized human DRG cell line that can differentiate into sensory neurons with nociceptive properties. The cell line HD10.6 represents the first example of a human sensory neuronal line and will be valuable for basic research, as well as for the discovery of novel drug targets and clinical candidates.
Dynamic material properties of the pregnant human uterus.
Manoogian, Sarah J; Bisplinghoff, Jill A; Kemper, Andrew R; Duma, Stefan M
2012-06-01
Given that automobile crashes are the largest single cause of death for pregnant females, scientists are developing advanced computer models of pregnant occupants. The purpose of this study is to quantify the dynamic material properties of the human uterus in order to increase the biofidelity of these models. A total of 19 dynamic tension tests were performed on pregnant human uterus tissues taken from six separate donors. The tissues were collected during full term Cesarean style deliveries and tested within 36 h of surgery. The tissues were processed into uniform coupon sections and tested at 1.5 strains/s using linear motors. Local stress and strain were determined from load data and optical markers using high speed video. The experiments resulted in a non-linear stress versus strain curves with an overall average peak failure true strain of 0.32±0.112 and a corresponding peak failure true stress of 656.3±483.9 kPa. These are the first data available for the dynamic response of pregnant human uterus tissues, and it is anticipated they will increase the accuracy of future pregnant female computational models.
Spectral and dynamical properties of a Zr-based MOF.
Gutiérrez, Mario; Sánchez, Félix; Douhal, Abderrazzak
2016-02-21
We report on the spectra and dynamics of a Zr-naphthalene dicarboxylic acid (Zr-NDC) MOF in different diluted solvent suspensions and in a concentrated tetrahydrofuran (THF) one. In a diluted diethyl ether (DE) suspension, we observed intraparticle excimer formation between neighboring naphthalene organic linkers, leading to a red-shifted broad band in the emission spectrum and to a dynamics composed of three components τ1 = 650 ps, τ2 = 3.7 ns and τ3 = 13.9 ns, assigned to the excimer photoproduction, monomer and excimer lifetimes, respectively. Furthermore, both absorption and emission spectra show a blue shift in more polar solvents characterized by the solvent polarity function f(ε,n). We also observed changes in the excimer formation time (490-840 ps) probably due to a variation in the MOF structural fluctuation induced by solvent filling. The global fluorescence quantum yield of these suspensions is around 0.30 ± 0.05. At higher concentrations of the MOF particles, we observed the absorption and emission signals of aggregates having an intercrystal excimer formation in ∼ 5 ps in a THF suspension, ∼ 100 times shorter than that observed in a diluted one. Our results give the spectral and dynamical properties of a Zr-NDC MOF in solvent suspensions, opening the way to further studies of these kinds of MOFs interacting with fluorescent dyes for possible photonic applications.
Temporal dynamics of connectivity and epidemic properties of growing networks
Fotouhi, Babak; Shirkoohi, Mehrdad Khani
2016-01-01
Traditional mathematical models of epidemic disease had for decades conventionally considered static structure for contacts. Recently, an upsurge of theoretical inquiry has strived towards rendering the models more realistic by incorporating the temporal aspects of networks of contacts, societal and online, that are of interest in the study of epidemics (and other similar diffusion processes). However, temporal dynamics have predominantly focused on link fluctuations and nodal activities, and less attention has been paid to the growth of the underlying network. Many real networks grow: Online networks are evidently in constant growth, and societal networks can grow due to migration flux and reproduction. The effect of network growth on the epidemic properties of networks is hitherto unknown, mainly due to the predominant focus of the network growth literature on the so-called steady state. This paper takes a step towards alleviating this gap. We analytically study the degree dynamics of a given arbitrary network that is subject to growth. We use the theoretical findings to predict the epidemic properties of the network as a function of time. We observe that the introduction of new individuals into the network can enhance or diminish its resilience against endemic outbreaks and investigate how this regime shift depends upon the connectivity of newcomers and on how they establish connections to existing nodes. Throughout, theoretical findings are corroborated with Monte Carlo simulations over synthetic and real networks. The results shed light on the effects of network growth on the future epidemic properties of networks and offers insights for devising a priori immunization strategies.
Structural dynamics and interfacial properties of filler-reinforced elastomers
Fritzsche, J; Klueppel, M, E-mail: Manfred.Klueppel@DIKautschuk.de [Deutsches Institut fuer Kautschuktechnologie e V, Eupener Strasse 33, D-30519 Hannover (Germany)
2011-01-26
The combined effect of filler networking and reduced chain mobility close to the filler interface is analyzed based on investigations of the relaxation dynamics of a solution of styrene butadiene rubber filled with different loadings and types of nanostructured carbon blacks. Dynamic-mechanical and dielectric spectra are studied in a wide frequency and temperature range. By referring to a tunneling process of charge carriers over nanoscopic gaps between adjacent carbon black particles the gap distance is evaluated from the dielectric spectra. This distance corresponds to the length of glassy-like polymer bridges forming flexible bonds between adjacent filler particles of the filler network. It is found that the gap distance decreases with increasing filler loading and specific surface area which correlates with an increase of the apparent activation energy of the filler network evaluated from dynamic-mechanical data. Due to the thermal activation of glassy-like polymer bridges the time-temperature superposition principle is not fulfilled for filled elastomers and the introduction of vertical shift factors is necessary to obtain viscoelastic master curves. The change in the low frequency viscoelastic properties by the incorporation of fillers is shown to be related to the superimposed dynamics of the filler network governed by the viscoelastic response of the glassy-like polymer bridges. This effect is distinguished from the reduced chain mobility close to the filler surface which results in a broadening of the glass transition on the high temperature or low frequency side. The microstructure-based interpretation of viscoelastic data is supported by an analysis of the relaxation time spectra.
Static and dynamic properties of critical fluctuations in lipid bilayers
Honerkamp-Smith, Aurelia Rose
A current popular view in cell biology is that sub-micron, dynamic heterogeneity in lipid and protein composition arises within the plasma membranes of resting cells. Local changes in membrane composition may affect protein activity, which is sensitive to the lipid environment. We have observed dynamic heterogeneity in lipid membranes in the form of composition fluctuations near a miscibility critical point. In this thesis we quantitatively describe the dynamic and static properties of these fluctuations. We evaluate the temperature dependence of line tension between liquid domains and of fluctuation correlation lengths in lipid membranes in order to extract a critical exponent, nu. We obtain nu = 1.2 +/- 0.2, consistent with the Ising model prediction nu = 1. From probability distributions of pixel intensities in fluorescence images of membranes, we also extract an independent critical exponent of beta = 0.124 +/- 0.03, which is consistent with the Ising prediction of beta = 1/8. We have systematically measured the effective dynamic critical exponent z eff in a lipid membrane while cooling the system toward a critical point. We observe that zeff slightly increases from a value of roughly 2.6 as xi → 0, to zeff = 3.0 +/- 0.15 at xi = 13 sm. Our measurements are consistent with the prediction that zeff → 3.00 as T → Tc for a 2-D system with conserved order parameter in contact with a bulk 3-D liquid. To our knowledge, no other systematic measurement of zeff with increasing xi exists for a 2-D system with conserved order parameter. We also report the solubility limit of several biologically relevant sterols in electroformed giant unilamellar vesicle membranes containing phosphatidylcholine (PC) lipids in ratios of 1:1:X DPPC:DOPC:sterol. We find solubility limits of cholesterol, lanosterol, ergosterol, stigmasterol, and beta-sitosterol using nuclear magnetic resonance.
Structural dynamics and interfacial properties of filler-reinforced elastomers
Fritzsche, J.; Klüppel, M.
2011-01-01
The combined effect of filler networking and reduced chain mobility close to the filler interface is analyzed based on investigations of the relaxation dynamics of a solution of styrene butadiene rubber filled with different loadings and types of nanostructured carbon blacks. Dynamic-mechanical and dielectric spectra are studied in a wide frequency and temperature range. By referring to a tunneling process of charge carriers over nanoscopic gaps between adjacent carbon black particles the gap distance is evaluated from the dielectric spectra. This distance corresponds to the length of glassy-like polymer bridges forming flexible bonds between adjacent filler particles of the filler network. It is found that the gap distance decreases with increasing filler loading and specific surface area which correlates with an increase of the apparent activation energy of the filler network evaluated from dynamic-mechanical data. Due to the thermal activation of glassy-like polymer bridges the time-temperature superposition principle is not fulfilled for filled elastomers and the introduction of vertical shift factors is necessary to obtain viscoelastic master curves. The change in the low frequency viscoelastic properties by the incorporation of fillers is shown to be related to the superimposed dynamics of the filler network governed by the viscoelastic response of the glassy-like polymer bridges. This effect is distinguished from the reduced chain mobility close to the filler surface which results in a broadening of the glass transition on the high temperature or low frequency side. The microstructure-based interpretation of viscoelastic data is supported by an analysis of the relaxation time spectra.
SYSTEMATIC AND DYNAMIC PROPER-TIES OF CASTING HOT SPOT
无
2003-01-01
The variation of casting hot spot with proceeding of solidification and components of casting-mold system is studied by the technique of numerical simulation of solidification.The result shows that the thickest part of casting is not exactly the last part of solidification in the casting, while the last part of solidification is not exactly casting hot spot at the early stage of solidification.The location, size, shape and number of casting hot spot change with geomitric, physical and technological factors of the casting-mold system such as thickness of the casting secondary wall and with the passage of time in the course of the solidification.The former is known as the systematic property of hot spot and the latter, dynamic property.Only when the properties of hot spot are grasped completely and accurately, can it be fed more effectively.By doing so, not only sound castings can be obtained, but also riser efficiency can be improved.
Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation.
Kouwenhoven, Evelyn N; Oti, Martin; Niehues, Hanna; van Heeringen, Simon J; Schalkwijk, Joost; Stunnenberg, Hendrik G; van Bokhoven, Hans; Zhou, Huiqing
2015-07-01
The transcription factor p63 plays a pivotal role in keratinocyte proliferation and differentiation in the epidermis. However, how p63 regulates epidermal genes during differentiation is not yet clear. Using epigenome profiling of differentiating human primary epidermal keratinocytes, we characterized a catalog of dynamically regulated genes and p63-bound regulatory elements that are relevant for epithelial development and related diseases. p63-bound regulatory elements occur as single or clustered enhancers, and remarkably, only a subset is active as defined by the co-presence of the active enhancer mark histone modification H3K27ac in epidermal keratinocytes. We show that the dynamics of gene expression correlates with the activity of p63-bound enhancers rather than with p63 binding itself. The activity of p63-bound enhancers is likely determined by other transcription factors that cooperate with p63. Our data show that inactive p63-bound enhancers in epidermal keratinocytes may be active during the development of other epithelial-related structures such as limbs and suggest that p63 bookmarks genomic loci during the commitment of the epithelial lineage and regulates genes through temporal- and spatial-specific active enhancers.
Dong Liang; Li-juan Zhou; Qin Zhang; Feng Chen; Ke Wang; Hua Deng; Qiang Fu
2012-01-01
The morphology and mechanical properties of poly(ethylene-octene) copolymers (POE) obtained by dynamic packing injection molding were investigated by mechanical tests,differential scanning calorimetry (DSC),fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).The mechanical tests found that only POE with low octene content and high molecular weight show apparent response for external shear field.Further investigation has been done by DSC,FT-IR,and SEM in order to make clear the reason of that phenomenon.Finally,the hypothetical mechanism of POE microstructure formation under shear field has been proposed.For POE with low octene content and high molecular weight,orientation degree and mechanical properties both increase substantially under shear field.For POE with low octene content and low molecular weight,orientation degree and crystallinity increase under shear field,but it is not dramatically benefit for the mechanical properties.For POE with high octene content and high molecular weight,the shear field has little effect on the morphology and mechanical properties.
Dynamic regulation of hepatic lipid droplet properties by diet.
Amanda E Crunk
Full Text Available Cytoplasmic lipid droplets (CLD are organelle-like structures that function in neutral lipid storage, transport and metabolism through the actions of specific surface-associated proteins. Although diet and metabolism influence hepatic CLD levels, how they affect CLD protein composition is largely unknown. We used non-biased, shotgun, proteomics in combination with metabolic analysis, quantitative immunoblotting, electron microscopy and confocal imaging to define the effects of low- and high-fat diets on CLD properties in fasted-refed mice. We found that the hepatic CLD proteome is distinct from that of CLD from other mammalian tissues, containing enzymes from multiple metabolic pathways. The hepatic CLD proteome is also differentially affected by dietary fat content and hepatic metabolic status. High fat feeding markedly increased the CLD surface density of perilipin-2, a critical regulator of hepatic neutral lipid storage, whereas it reduced CLD levels of betaine-homocysteine S-methyltransferase, an enzyme regulator of homocysteine levels linked to fatty liver disease and hepatocellular carcinoma. Collectively our data demonstrate that the hepatic CLD proteome is enriched in metabolic enzymes, and that it is qualitatively and quantitatively regulated by diet and metabolism. These findings implicate CLD in the regulation of hepatic metabolic processes, and suggest that their properties undergo reorganization in response to hepatic metabolic demands.
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
Giuseppina Giglia-Mari
2009-10-01
Full Text Available Studies based on cell-free systems and on in vitro-cultured living cells support the concept that many cellular processes, such as transcription initiation, are highly dynamic: individual proteins stochastically bind to their substrates and disassemble after reaction completion. This dynamic nature allows quick adaptation of transcription to changing conditions. However, it is unknown to what extent this dynamic transcription organization holds for postmitotic cells embedded in mammalian tissue. To allow analysis of transcription initiation dynamics directly into living mammalian tissues, we created a knock-in mouse model expressing fluorescently tagged TFIIH. Surprisingly and in contrast to what has been observed in cultured and proliferating cells, postmitotic murine cells embedded in their tissue exhibit a strong and long-lasting transcription-dependent immobilization of TFIIH. This immobilization is both differentiation driven and development dependent. Furthermore, although very statically bound, TFIIH can be remobilized to respond to new transcriptional needs. This divergent spatiotemporal transcriptional organization in different cells of the soma revisits the generally accepted highly dynamic concept of the kinetic framework of transcription and shows how basic processes, such as transcription, can be organized in a fundamentally different fashion in intact organisms as previously deduced from in vitro studies.
JunShan; XioomeiWang; JianminXu; HongliXu; XiaofengFeng; JingshanGong; RennanLing; ZibinRao
2004-01-01
OBJECTIVE To study the value of dynamic enhanced MR imaging in the differential diagnosis between ovarian fibroma and subserosal leiomyoma, both of which produce a intermediate to low signal intensity on T2W1. METHODS Plain and dynamic enhanced MRI results of 45 patients were analyzed, 35 cases of which were subserosal leiomyoma and 10 were ovarian fibroma. All of the tumors were verified by histologic analysis. RESULTS The 10 ovarian fibroma cases showed low signal intensities on T1W1, but 2 produced intermediate signal intensities and 8 showed low signal intensities on T2W1. There was little enhancement of the early phase and the delayed phase was long, so the enhancement index of the early phase (SI100) was low and the time to peak (TTP200) was long. Of the 35 subserosal leiomyoma cases, all showed low signal intensity on TlWl, 7 were intermediate in signal intensity and 28 generated a low signal intensity on T2W1. The enhancement of the early phase was moderate to highlyevident and the index was high. The time to peak was short (TTP200). The enhancement -time curve was different in the two groups, and the differencehad statistical sianificance (P<0.001). CONCLUSION Dynamic enhanced MR imaging was helpful in the differential diagnosis between ovarian fibroma and subserosal leiomyoma by the difference of the early phase enhancement.
Elschner, Robert; de Melo, Alessandro Marques; Bunge, Christian-Alexander; Petermann, Klaus
2007-01-15
We studied the amplitude and phase noise suppression properties of an all-optical regenerator for differential phase-shift keying data. A detailed analytical investigation is performed and compared with numerical simulations for different working points. The results show that both amplitude and phase can be regenerated. However, simultaneous amplitude and phase noise suppression is possible only if the phase degradation is stronger than the amplitude degradation, for instance, due to nonlinear phase noise.
Martí, J; Nagy, G; Guàrdia, E; Gordillo, M C
2006-11-30
Electric and dielectric properties and microscopic dynamics of liquid water confined between graphite slabs are analyzed by means of molecular dynamics simulations for several graphite-graphite separations at ambient conditions. The electric potential across the interface shows oscillations due to water layering, and the overall potential drop is about -0.28 V. The total dielectric constant is larger than the corresponding value for the bulklike internal region of the system. This is mainly due to the preferential orientations of water nearest the graphite walls. Estimation of the capacitance of the system is reported, indicating large variations for the different adsorption layers. The main trend observed concerning water diffusion is 2-fold: on one hand, the overall diffusion of water is markedly smaller for the closest graphite-graphite separations, and on the other hand, water molecules diffuse in interfaces slightly slower than those in the bulklike internal areas. Molecular reorientational times are generally larger than those corresponding to those of unconstrained bulk water. The analysis of spectral densities revealed significant spectral shifts, compared to the bands in unconstrained water, in different frequency regions, and associated to confinement effects. These findings are important because of the scarce information available from experimental, theoretical, and computer simulation research into the dielectric and dynamical properties of confined water.
Wan, Wu-Bing; Lv, Hong-Hong; Merlitz, Holger; Wu, Chen-Xu
2016-10-01
By defining a topological constraint value (rn), the static and dynamic properties of a polymer brush composed of moderate or short chains with different topological ring structures are studied using molecular dynamics simulation, and a comparison with those of linear polymer brush is also made. For the center-of-mass height of the ring polymer brush scaled by chain length h ˜ N ν , there is no significant difference of exponent from that of a linear brush in the small topological constraint regime. However, as the topological constraint becomes stronger, one obtains a smaller exponent. It is found that there exists a master scaling power law of the total stretching energy scaled by chain length N for moderate chain length regime, F ene ˜ Nρ ν , for ring polymer brushes, but with a larger exponent ν than 5/6, indicating an influence of topological constraint to the dynamic properties of the system. A topological invariant of free energy scaled by 5/4 is found. Project supported by the National Natural Science Foundation of China (Grant Nos. 11374243 and 11574256).
Differential kinetic dynamics and heating of ions in the turbulent solar wind
Valentini, F; Stabile, S; Pezzi, O; Servidio, S; De Marco, R; Marcucci, F; Bruno, R; Lavraud, B; De Keyser, J; Consolini, G; Brienza, D; Sorriso-Valvo, L; Retinò, A; Vaivads, A; Salatti, M; Veltri, P
2016-01-01
The solar wind plasma is a fully ionized and turbulent gas ejected by the outer layers of the solar corona at very high speed, mainly composed by protons and electrons, with a small percentage of helium nuclei and a significantly lower abundance of heavier ions. Since particle collisions are practically negligible, the solar wind is typically not in a state of thermodynamic equilibrium. Such a complex system must be described through self-consistent and fully nonlinear models, taking into account its multi-species composition and turbulence. We use a kinetic hybrid Vlasov-Maxwell numerical code to reproduce the turbulent energy cascade down to ion kinetic scales, in typical conditions of the uncontaminated solar wind plasma, with the aim of exploring the differential kinetic dynamics of the dominant ion species, namely protons and alpha particles. We show that the response of different species to the fluctuating electromagnetic fields is different. In particular, a significant differential heating of alphas w...
Differential Neural Networks for Identification and Filtering in Nonlinear Dynamic Games
Emmanuel García
2014-01-01
Full Text Available This paper deals with the problem of identifying and filtering a class of continuous-time nonlinear dynamic games (nonlinear differential games subject to additive and undesired deterministic perturbations. Moreover, the mathematical model of this class is completely unknown with the exception of the control actions of each player, and even though the deterministic noises are known, their power (or their effect is not. Therefore, two differential neural networks are designed in order to obtain a feedback (perfect state information pattern for the mentioned class of games. In this way, the stability conditions for two state identification errors and for a filtering error are established, the upper bounds of these errors are obtained, and two new learning laws for each neural network are suggested. Finally, an illustrating example shows the applicability of this approach.
Some Chaotic Properties of Discrete Fuzzy Dynamical Systems
Yaoyao Lan
2012-01-01
Full Text Available Letting (X,d be a metric space, f:X→X a continuous map, and (ℱ(X,D the space of nonempty fuzzy compact subsets of X with the Hausdorff metric, one may study the dynamical properties of the Zadeh's extension f̂:ℱ(X→ℱ(X:u↦f̂u. In this paper, we present, as a response to the question proposed by Román-Flores and Chalco-Cano 2008, some chaotic relations between f and f̂. More specifically, we study the transitivity, weakly mixing, periodic density in system (X,f, and its connections with the same ones in its fuzzified system.
Static and dynamic properties of QCD bound states
Kubrak, Stanislav
2015-07-01
The QCD phenomenology can be faced with the framework of the coupled quark DSE, meson BSE and baryon Faddeev equation, providing non-perturbative, continuum and Poincare invariant scientific approach. The research performed throughout this thesis is twofold. From one perspective we focus on the investigation of mass spectra for mesons with total spin quantum number J=3 and arising Regge-trajectory for natural parity states J{sup PC}=1{sup --},2{sup ++},3{sup --} within rainbow-ladder single gluon exchange model. The other findings are concerning the impact of the pion cloud effect on J>2 meson states, baryon masses, namely on Nucleon and Delta three-body bound states and meson dynamical properties like the pion form factor.
Transport Properties of Fluids in Micropores by Molecular Dynamics Simulation
LIU, Ying-Chun(刘迎春); WANG, Qi(王琦); Lü, Ling-Hong(吕玲红)
2004-01-01
The transport properties of fluid argon in micropores, i.e. diffusivity and viscosity, were studied by molecular dynamics simulations. The effects of pore width, temperature and density on diffusivity and viscosity were analyzed in micropores with pore widths from 0.8 to 4.0 nm. The results show that the diffusivity in micropores is much lower than the bulk diffusivity, and it decreases as the pore width decreases; but the viscosity in micropores is significantly larger than the bulk one, and it increases sharply in narrow micropores. The diffusivity in channel parallel direction is obviously larger than that in channel perpendicular direction. The temperature and density are important factors that obviously affect diffusivity and viscosity in micropores.
Molecular dynamics simulation of thermodynamic properties of YAG
Chen Jun; Chen Dong-Quan; Zhang Jing-Lin
2007-01-01
In this paper we study the thermodynamic properties of Y3Al5O12 (YAG) by using molecular dynamic method combined with two- and three-body potentials. The dependences of melting process, elastic constant and diffusion coefficient on temperature of crystal YAG are simulated and compared with the experimental results. Our results show that anion O has the biggest self-diffusivity and cation Y has the smallest self-diffusivity in a crystal YAG. The calculated diffusion activation energies of ions O, Al and Y are 282.55, 439.46, 469.71k J/mol, respectively. Comparing with experimental creep activation energy of YAG confirms that cation Y can restrict the diffusional creep rate of crystal YAG.
Dynamic Tensile Properties of Concrete under Different Environments
YAN Dongming; LIN Gao
2006-01-01
By using an MTS810 hydra-electro-servo universal machine, the effect of moisture content and temperature on the rate sensitivity of concrete was investigated, the range of strain rate was varying from 10-5 /s to 10-0.3/s. It is concluded from the tests that the water content has a significant influence on the rate sensitivity of concrete whereas the temperature has a slight one, and the effects of rate sensitivity are attributed to both the viscosity caused by free water and the transformation of fracture mode when subjected to a high strain rate. The dynamic strength, initial modulus of elasticity , critical strain, Poisson ratio and energy absorption properties were studied systematically. It is found that the strength, initial modulus of elasticity, critical strain, and energy absorption capacity of concrete all increase with the increasing strain rate, whereas Poisson ratio keeps almost unchanged.
A molecular dynamics study on surface properties of supercooled water
L(U) Yongjun; WEI Bingbo
2006-01-01
Molecular dynamics simulations were performed to study the surface properties of water in a temperature range from 228 to 293 K by using the extended simple point charge (SPC/E) and four-site TIP4P potentials. The calculated surface tension increases with the decrease of temperature, and moreover the slopes of the surface tension-temperature curves show a weak rise below 273 K, whereas no obvious anomalies appear near 228 K, which accords with the previous experiments. Compared with the measured values, the SPC/E potential shows a good agreement, and the TIP4P potential scription of the surface structure of supercooled water for the SPC/E. When simulating the orientational distributions of water molecules near the surface, the SPC/E potential produces higher ordering and larger surface potentials than the TIP4P potential.
Static and Dynamic Properties of Semi-Crystalline Polyethylene
Ming-ming Xu
2016-03-01
Full Text Available Properties of extruded polymers are strongly affected by molecular structure. For two different semi-crystalline polymers, low-density polyethylene (LDPE and ultra-high molecular weight polyethylene (UHMWPE, this investigation measures the elastic modulus, plastic flow stress and strain-rate dependence of yield stress. Also, it examines the effect of molecular structure on post-necking tensile fracture. The static and dynamic material tests reveal that extruded UHMWPE has a somewhat larger yield stress and much larger strain to failure than LDPE. For both types of polyethylene, the strain at tensile failure decreases with increasing strain-rate. For strain-rates 0.001–3400 s−1, the yield stress variation is accurately represented by the Cowper–Symonds equation. These results indicate that, at high strain rates, UHMWPE is more energy absorbent than LDPE as a result of its long chain molecular structure with few branches.
Xie, Jun Yu; Ding, Guang Hong; Karttunen, Mikko
2014-03-01
Membranes' response to lateral tension, and eventual rupture, remains poorly understood. In this study, pure dipalmitoylphosphatidylcholine (DPPC) lipid bilayers, under tension/pressure, were studied using molecular dynamics (MD) simulations. The irreversible membrane breakdown is demonstrated to depend on the amplitude of lateral tension, loading rate, and the size of the bilayer. In all of our simulations, -200bar lateral pressure was found to be enough to rupture lipid membrane regardless of the loading rate or the membrane size. Loading rate and membrane size had a significant impact on rupture. A variety of dynamic properties of lipid molecules, probability distribution of area per lipid particularly, have been determined, and found to be fundamental for describing membrane behavior in detail, thus providing the quantitative description for the requirement of membrane rupture.
Simulation of quantum dynamics based on the quantum stochastic differential equation.
Li, Ming
2013-01-01
The quantum stochastic differential equation derived from the Lindblad form quantum master equation is investigated. The general formulation in terms of environment operators representing the quantum state diffusion is given. The numerical simulation algorithm of stochastic process of direct photodetection of a driven two-level system for the predictions of the dynamical behavior is proposed. The effectiveness and superiority of the algorithm are verified by the performance analysis of the accuracy and the computational cost in comparison with the classical Runge-Kutta algorithm.
Aziz, Jonathan D.; Parker, Jeffrey S.; Scheeres, Daniel J.; Englander, Jacob A.
2017-01-01
Low-thrust trajectories about planetary bodies characteristically span a high count of orbital revolutions. Directing the thrust vector over many revolutions presents a challenging optimization problem for any conventional strategy. This paper demonstrates the tractability of low-thrust trajectory optimization about planetary bodies by applying a Sundman transformation to change the independent variable of the spacecraft equations of motion to the eccentric anomaly and performing the optimization with differential dynamic programming. Fuel-optimal geocentric transfers are shown in excess of 1000 revolutions while subject to Earths J2 perturbation and lunar gravity.
Shujian Ma
2016-01-01
Full Text Available A government-market-public partnership (GMPP could be a feasible arrangement for providing insurance coverage for natural disaster. Firstly, we put forward GMPP management mode. Secondly, the emergency financial service supply chain for natural disaster risk is built from the view of supply chain. Finally, the objective of this paper is to obtain insights into the cooperative and competitive relationship in GMPP system. We establish the cooperative and competitive differential dynamic evolutionary models and prove the existence of equilibrium solutions in order to solve the coordination problems. In conclusion, the equilibrium solutions can be achieved among the insurers, the operating governments, and the public.
孙鹏; 尤锋; 刘梦侠; 吴志昊; 文爱韵; 李军; 徐永立; 张培军
2010-01-01
Steroid sex hormones,such as estradiol-17β(E2)and testosterone(T),are important regulators of sex change in fish.In this study,we examined the effects of E2 treatment on the dynamics of E2 and T during gonadal differentiation in the olive flounder Paralichthys olivaceus using histology and radioimmunoassay(RIA).Flounder larvae were divided into five groups(G0–G4),and fed with 0 (control),0.2,2,20 and 100 mg E2/kg feed from 35 to 110 day post hatching(dph).Fish growth in the G1 and G2 groups was not signific...
Structural and dynamical properties of liquid Al-Au alloys
Peng, H. L.; Voigtmann, Th.; Kolland, G.; Kobatake, H.; Brillo, J.
2015-11-01
We investigate temperature- and composition-dependent structural and dynamical properties of Al-Au melts. Experiments are performed to obtain accurate density and viscosity data. The system shows a strong negative excess volume, similar to other Al-based binary alloys. We develop a molecular-dynamics (MD) model of the melt based on the embedded-atom method (EAM), gauged against the available experimental liquid-state data. A rescaling of previous EAM potentials for solid-state Au and Al improves the quantitative agreement with experimental data in the melt. In the MD simulation, the admixture of Au to Al can be interpreted as causing a local compression of the less dense Al system, driven by less soft Au-Au interactions. This local compression provides a microscopic mechanism explaining the strong negative excess volume of the melt. We further discuss the concentration dependence of self- and interdiffusion and viscosity in the MD model. Al atoms are more mobile than Au, and their increased mobility is linked to a lower viscosity of the melt.
Dynamic thermo-mechanical properties of various flowable resin composites
Balthazard, Rémy; Vincent, Marin; Dahoun, Abdessellam; Mortier, Eric
2016-01-01
Background This study compared the storage modulus (E’), the loss modulus (E’’) and the loss tangent (tan δ) of various flowable resin composites. Material and Methods Grandio Flow (GRF), GrandioSo Heavy Flow (GHF), Filtek Supreme XTE (XTE) and Filtek Bulk Fill (BUL) flowable resins and Clinpro Sealant (CLI) ultra-flowable pit and fissure sealant resin were used. 25 samples were tested using a dynamical mechanical thermal analysis system in bending mode. Measurements were taken within a temperature range of 10 to 55°C. The results were statistically analyzed using mixed-effect and repeated-measure analysis of variance followed by paired multiple comparisons. Results For all the materials, the E’ values decrease with temperature, whereas the tan δ values increase. Irrespective of the temperature, GHF and GRF present E’ and E’’ values significantly higher than all the other materials and CLI presents values significantly lower than all the other materials. Observation of the values for all the materials reveals a linear progression of the tan δ values with temperature. Conclusions A variation in temperature within a physiological range generates modifications in mechanical properties without damaging the material, however. Filler content in volume terms appears to be the crucial parameter in the mechanical behavior of tested materials. Key words:Dynamic mechanical thermal analysis, elastic modulus, filler content, flowable resin composites, loss modulus, loss tangent. PMID:27957266
Rapid cable tension estimation using dynamic and mechanical properties
Martínez-Castro, Rosana E.; Jang, Shinae; Christenson, Richard E.
2016-04-01
Main tension elements are critical to the overall stability of cable-supported bridges. A dependable and rapid determination of cable tension is desired to assess the state of a cable-supported bridge and evaluate its operability. A portable smart sensor setup is presented to reduce post-processing time and deployment complexity while reliably determining cable tension using dynamic characteristics extracted from spectral analysis. A self-recording accelerometer is coupled with a single-board microcomputer that communicates wirelessly with a remote host computer. The portable smart sensing device is designed such that additional algorithms, sensors and controlling devices for various monitoring applications can be installed and operated for additional structural assessment. The tension-estimating algorithms are based on taut string theory and expand to consider bending stiffness. The successful combination of cable properties allows the use of a cable's dynamic behavior to determine tension force. The tension-estimating algorithms are experimentally validated on a through-arch steel bridge subject to ambient vibration induced by passing traffic. The tension estimation is determined in well agreement with previously determined tension values for the structure.
A Method to Analyze Dynamics Properties of Transfemoral Prosthesis
Van Tuan Le
2016-01-01
Full Text Available Abstract.The methodto compute gait cycle forces and moments acting on the hip and knee joints of a lower limb with a trans-femoral prosthesis were investigated. A 3D model of the lower limb with prosthesis was created using CAD software and based on MRI data and real size dimension. The transfemoral prosthesis was modelled as a coupled of links with two revolution joints at hip and knee joint. This coupled link was connected to a bar with translation joint to description the distance walked of people in gait cycle. All parts of the prosthesis were measured and a full-size 3D model was created.The kinematics parameters of a lower limb with a prosthesis were determined from motion-captured system data. The reaction force was measured with a force sensor in the footplate. The 3D model of the prosthesis was exported to MatlabSimmechanics. The input data which are kinematic parameters were applied to calculate the forces and moments acting on the joints. The results of this study present a method to analyse the dynamic properties of transfemoral prosthesis including speed of the gait. It could be used to calculate the load transferred from the socket to the residual limb. They could also be used to design the structure of a prosthesis and optimize the dynamic characteristics of such a prosthesis.
Influence of snow-cover properties on avalanche dynamics
Steinkogler, W.; Sovilla, B.; Lehning, M.
2012-04-01
Snow avalanches with the potential of reaching traffic routes and settlements are a permanent winter threat for many mountain communities. Snow safety officers have to take the decision whether to close a road, a railway line or a ski slope. Those decisions are often very difficult as they demand the ability to interpret weather forecasts, to establish their implication for the stability and the structure of the snow cover and to evaluate the influence of the snow cover on avalanche run-out distances. In the operational programme 'Italy-Switzerland, project STRADA' we focus on the effects of snow cover on avalanche dynamics, and thus run-out distance, with the aim to provide a better understanding of this influence and to ultimately develop tools to support snow safety officers in their decision process. We selected five avalanches, measured at the Vallée de la Sionne field site, with similar initial mass and topography but different flow dynamics and run-out distances. Significant differences amongst the individual avalanches could be observed for front and internal velocities, impact pressures, flow regimes, deposition volumes and run-out distances. For each of these avalanches, the prevailing snow conditions at release were reconstructed using field data from local snowpits or were modeled with SNOWPACK. Combining flow dynamical data with snow cover properties shows that erodible snow depth, snow density and snow temperature in the snow pack along the avalanche track are among the decisive variables that appear to explain the observed differences. It is further discussed, how these influencing factors can be quantified and used for improved predictions of site and time specific avalanche hazard.
Structure and properties of forsterite-MgSiO3 liquid interface: molecular dynamics study
Noritake, Fumiya; Kawamura, Katsuyuki
2014-01-01
.... We performed molecular dynamics simulations in terms of structures and diffusivities in forsterite-MgSiO3 liquid interfaces to obtain the nanoscale dynamic properties and structure of the interface...
Rodríguez, Marcos; Blesa, Fernando; Barrio, Roberto
2015-07-01
In many physical problems the use of numerical simulations presents the only path to obtain insight into the behavior and evolution of the system of interest. GPU, CPU and MIC technologies are frequently employed for simulations on computational dynamics and we present results comparing different schemes for the numerical integration of ordinary differential systems (ODEs) in these architectures. The use of adapted methods with low memory storage (Low storage Runge-Kutta methods) gives good results for low precision studies, whereas the Taylor series method provides a powerful technique for high precision. We show how the computation of several dynamics indicators, such as a fast chaos indicator (FLI) or a phase shift indicator in small neuron networks (Central Pattern Generators), can be efficiently computed on these architectures by means of the numerical ODE methods executed through OpenCL. This high computational time reduction allows real-time simulations or generating video media.
The effect of dynamical screening on helium (e, 2e) fully differential cross-sections
Sun Shi-Yan; Jia Xiang-Fu; Miao Xiang-Yang; Zhang Jun-Feng; Xie Yi; Li Xiong-Wei; Shi Wen-Qiang
2009-01-01
This paper presents the fully differential cross sections (FDCS) for 102eV electron impact single ionization of helium for both the coplanar and perpendicular plane asymmetric geometries within the framework of dynamically screened three-Coulomb-wave theory. Comparisons are made with the experimental data and those of the three-Coulomb wave function model and second-order distorted-wave Born method. The angular distribution and relative heights of the present FDCS is found to be in very good agreement with the experimental data in the perpendicular plane geometry.It is shown that dynamical screening effects are significant in this geometry. Three-body coupling is expected to be weak in the coplanar geometry, although the precise absolute value of the cross section is still sensitive to the interaction details.
Iversen, Jan Emil Banning; Morales González, Juan Miguel; Møller, Jan Kloppenborg
2017-01-01
a dynamic power curve. The model thus decomposes the dynamics of wind power prediction errors into wind speed forecast errors and errors related to the conversion from wind speed to wind power. We test the proposed model on an out-of-sample period of 1 year for a wind farm with a rated capacity of 21 MW...... of the uncertainty over time or the inter-temporal correlation of forecast errors for different horizons. This information is very important for forecast end-users optimizing time-dependent variables or dealing with multi-period decision-making problems, such as the management and operation of power systems...... with a high penetration of renewable generation. This paper provides input to these problems by proposing a model based on stochastic differential equations that allows generating predictive densities as well as scenarios for wind power. We build upon a probabilistic model for wind speed and introduce...
Amengonu, Yawo H.; Kakad, Yogendra P.
2014-07-01
Quasivelocity techniques such as Maggi's and Boltzmann-Hamel's equations eliminate Lagrange multipliers from the beginning as opposed to the Euler-Lagrange method where one has to solve for the n configuration variables and the multipliers as functions of time when there are m nonholonomic constraints. Maggi's equation produces n second-order differential equations of which (n-m) are derived using (n-m) independent quasivelocities and the time derivative of the m kinematic constraints which add the remaining m second order differential equations. This technique is applied to derive the dynamics of a differential mobile robot and a controller which takes into account these dynamics is developed.
Mechanical properties of Indonesian-made narrow dynamic compression plate.
Dewo, P; van der Houwen, E B; Sharma, P K; Magetsari, R; Bor, T C; Vargas-Llona, L D; van Horn, J R; Busscher, H J; Verkerke, G J
2012-09-01
Osteosynthesis plates are clinically used to fixate and position a fractured bone. They should have the ability to withstand cyclic loads produced by muscle contractions and total body weight. The very high demand for osteosynthesis plates in developing countries in general and in Indonesia in particular necessitates the utilisation of local products. In this paper, we investigated the mechanical properties, i.e. proportional limit and fatigue strength of Indonesian-made Narrow Dynamic Compression Plates (Narrow DCP) as one of the most frequently used osteosynthesis plates, in comparison to the European AO standard plate, and its relationship to geometry, micro structural features and surface defects of the plates. All Indonesian-made plates appeared to be weaker than the standard Narrow DCP because they consistently failed at lower stresses. Surface defects did not play a major role in this, although the polishing of the Indonesian Narrow DCP was found to be poor. The standard plate showed indications of cold deformation from the production process in contrast to the Indonesian plates, which might be the first reason for the differences in strength. This is confirmed by hardness measurements. A second reason could be the use of an inferior version of stainless steel. The Indonesian plates showed lower mechanical behaviour compared to the AO-plates. These findings could initiate the development of improved Indonesian manufactured DCP-plates with properties comparable to commonly used plates, such as the standard European AO-plates.
Design of Ordered Wrinkled Patterns with Dynamically Tuned Properties
Yagüe, Jose Luis; Yin, Jie; Boyce, Mary C.; Gleason, Karen K.
The formation of patterned surfaces is a common tool to engineer materials. The capability to design and reproduce detailed features is a key factor to fulfill requirements for functional surfaces. Generation of wrinkles via buckling of a stiff film on a compliant surface is an inexpensive, easy and reliable method to yield a patterned surface. The wrinkling method has been exploited in a wide variety of areas, including photovoltaics, microfluidics, adhesion, and anti-fouling systems. Here we show the ability to obtain deterministically ordered herringbone patterns. In a biaxially pre-stretched PDMS sample a thin film of a stiff coating is deposited by initiated chemical vapor deposition (iCVD). iCVD is a solvent- free technique that yields a conformal thin coating on virtually any substrate, giving a controllable thickness and tunable structural, mechanical, thermal, wetting, and swelling properties. Sequential release of the film-substrate system shows the transition from 1-D ripples to an ordered herringbone pattern. Wrinkle features can be controlled adjusting the film thickness, the initial load and the release process. Moreover, the surface topography can be dynamically tuned by applying a controlled mechanical stimulus. These properties make these materials excellent candidates for flexible applications.
Stability properties of elementary dynamic models of membrane transport.
Hernández, Julio A
2003-01-01
Living cells are characterized by their capacity to maintain a stable steady state. For instance, cells are able to conserve their volume, internal ionic composition and electrical potential difference across the plasma membrane within values compatible with the overall cell functions. The dynamics of these cellular variables is described by complex integrated models of membrane transport. Some clues for the understanding of the processes involved in global cellular homeostasis may be obtained by the study of the local stability properties of some partial cellular processes. As an example of this approach, I perform, in this study, the neighborhood stability analysis of some elementary integrated models of membrane transport. In essence, the models describe the rate of change of the intracellular concentration of a ligand subject to active and passive transport across the plasma membrane of an ideal cell. The ligand can be ionic or nonionic, and it can affect the cell volume or the plasma membrane potential. The fundamental finding of this study is that, within the physiological range, the steady states are asymptotically stable. This basic property is a necessary consequence of the general forms of the expressions employed to describe the active and passive fluxes of the transported ligand.
Dynamic mechanical and swelling properties of maleated hyaluronic acid hydrogels.
Lin, Hai; Liu, Jun; Zhang, Kai; Fan, Yujiang; Zhang, Xingdong
2015-06-05
A series of maleated hyaluronan (MaHA) are developed by modification with maleic anhydride. The degrees of substitution (DS) of MaHA vary between 7% and 75%. The DS of MaHA is both higher and wider than methacrylated HA derivatives (MeHA) reported in the literature. MaHA hydrogels are then prepared by photopolymerization and their dynamic mechanical and swelling properties of the hydrogels are investigated. The results showed that MaHA hydrogels with moderate DS (25%, 50% and 65%) have higher storage modulus and lower equilibrium swelling ratios than those with either low or high DS (7%, 15% and 75%). Theoretical analyses also suggest a similar pattern among hydrogels with different DS. The results confirm that the increased cross-linking density enhances the strength of hydrogels. Meanwhile, the hydrophilicity of introduced groups during modification and the degree of incomplete crosslinking reaction might have negative impact on the mechanical and swelling properties of MaHA hydrogels.
Mora Van Cauwelaert, Emilio; Arias Del Angel, Juan A.; Benítez, Mariana; Azpeitia, Eugenio M.
2015-01-01
Multicellularity has emerged and continues to emerge in a variety of lineages and under diverse environmental conditions. In order to attain individuality and integration, multicellular organisms must exhibit spatial cell differentiation, which in turn allows cell aggregates to robustly generate traits and behaviors at the multicellular level. Nevertheless, the mechanisms that may lead to the development of cellular differentiation and patterning in emerging multicellular organisms remain unclear. We briefly review two conceptual frameworks that have addressed this issue: the cooperation-defection framework and the dynamical patterning modules (DPMs) framework. Then, situating ourselves in the DPM formalism first put forward by S. A. Newman and collaborators, we state a hypothesis for cell differentiation and arrangement in cellular masses of emerging multicellular organisms. Our hypothesis is based on the role of the generic cell-to-cell communication and adhesion patterning mechanisms, which are two fundamental mechanisms for the evolution of multicellularity, and whose molecules seem to be well-conserved in extant multicellular organisms and their unicellular relatives. We review some fundamental ideas underlying this hypothesis and contrast them with empirical and theoretical evidence currently available. Next, we use a mathematical model to illustrate how the mechanisms and assumptions considered in the hypothesis we postulate may render stereotypical arrangements of differentiated cells in an emerging cellular aggregate and may contribute to the variation and recreation of multicellular phenotypes. Finally, we discuss the potential implications of our approach and compare them to those entailed by the cooperation-defection framework in the study of cell differentiation in the transition to multicellularity. PMID:26157427
Deirdre A. Nelson
2013-04-01
Epithelial organ morphogenesis involves reciprocal interactions between epithelial and mesenchymal cell types to balance progenitor cell retention and expansion with cell differentiation for evolution of tissue architecture. Underlying submandibular salivary gland branching morphogenesis is the regulated proliferation and differentiation of perhaps several progenitor cell populations, which have not been characterized throughout development, and yet are critical for understanding organ development, regeneration, and disease. Here we applied a serial multiplexed fluorescent immunohistochemistry technology to map the progressive refinement of the epithelial and mesenchymal cell populations throughout development from embryonic day 14 through postnatal day 20. Using computational single cell analysis methods, we simultaneously mapped the evolving temporal and spatial location of epithelial cells expressing subsets of differentiation and progenitor markers throughout salivary gland development. We mapped epithelial cell differentiation markers, including aquaporin 5, PSP, SABPA, and mucin 10 (acinar cells; cytokeratin 7 (ductal cells; and smooth muscle α-actin (myoepithelial cells and epithelial progenitor cell markers, cytokeratin 5 and c-kit. We used pairwise correlation and visual mapping of the cells in multiplexed images to quantify the number of single- and double-positive cells expressing these differentiation and progenitor markers at each developmental stage. We identified smooth muscle α-actin as a putative early myoepithelial progenitor marker that is expressed in cytokeratin 5-negative cells. Additionally, our results reveal dynamic expansion and redistributions of c-kit- and K5-positive progenitor cell populations throughout development and in postnatal glands. The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis.
Capasso, M.; Cefis, E.; Frenken, K.
We compare the industrial dynamics in the core, semi-periphery and periphery in The Netherlands in terms of firm entry-exit, size, growth and sectoral location patterns. The contribution of our work is to provide the first comprehensive study on spatial differentiation in industrial dynamics for all
Amengonu, Yawo H.; Kakad, Yogendra P.
2014-07-01
Quasivelocity techniques were applied to derive the dynamics of a Differential Wheeled Mobile Robot (DWMR) in the companion paper. The present paper formulates a control system design for trajectory tracking of this class of robots. The method develops a feedback linearization technique for the nonlinear system using dynamic extension algorithm. The effectiveness of the nonlinear controller is illustrated with simulation example.
G.M. Bhuiyan
2012-10-01
Full Text Available Several static and dynamic properties of liquid Cu, Ag and Au at thermodynamic states near their respective melting points, have been evaluated by means of the orbital free ab-initio molecular dynamics simulation method. The calculated static structure shows good agreement with the available X-ray and neutron diffraction data. As for the dynamic properties, the calculated dynamic structure factors point to the existence of collective density excitations along with a positive dispersion for l-Cu and l-Ag. Several transport coefficients have been obtained which show a reasonable agreement with the available experimental data.
Bhuiyan, G M; González, D J; 10.5488/CMP.15.33604
2012-01-01
Several static and dynamic properties of liquid Cu, Ag and Au at thermodynamic states near their respective melting points, have been evaluated by means of the orbital free ab-initio molecular dynamics simulation method. The calculated static structure shows good agreement with the available X-ray and neutron diffraction data. As for the dynamic properties, the calculated dynamic structure factors point to the existence of collective density excitations along with a positive dispersion for l-Cu and l-Ag. Several transport coefficients have been obtained which show a reasonable agreement with the available experimental data.
Unstable Dynamical Properties of Spiral Cloud Bands in Tropical Cyclones
HUANG Hong; ZHANG Ming
2009-01-01
A nondivergent barotropic model (Model 1) and a barotropic primitive equation vortex model (Model 2) are linearized respectively in this paper. Then their perturbation wave spectrums are computed with a normal mode approach to study the instability problem on an appointed tropical cyclone (TC)-like vortex, thereby, the dynamic instability properties of spiral cloud bands of TCs are discussed. The results show that the unstable mode of both models exhibits a spiral band-like structure that propagates away from the vortex outside the radius of maximum winds. The discrete modal instability of the pure vortex Rossby wave can account for the generation of the eyewall and the inner spiral band. The unstable mode in Model 2 has three parts, i.e., eyewall, inner and outer spiral bands. This mode can be interpreted as a mixed vortex Rossby-inertia gravitational wave. The unbalanced property of the wave outside the stagnation radius of the vortex Rossby wave is one of the important reasons for the formation of the outer spiral band in TCs. Accordingly, the outer spiral band can be identified to possess properties of an inertial-gravitational wave.When the formation of unstable inner and outer spiral bands is studied, a barotropic vortex model shall be used. In this model, the most unstable perturbation bears the attributes of either the vortex Rossby wave or the inertial-gravitational wave, depending on the vortex radius. So such perturbations shall be viewed as an unbalanced and unstable mixed wave of these two kinds of waves.
Thomsen, Jon Juel; Blekhman, Iliya I.
2007-01-01
, and to call these dynamic materials or spatiotemporal composites. Also, according to theoretical predictions, structural nonlinearity enhances the possibilities of achieving specific effective properties. For example, with an elastic rod having cubical elastic nonlinearities, it seems possible to control......, and exemplified. Then simple approximate analytical expressions are derived for the effective wave speed and natural frequencies for one-dimensional wave propagation in a nonlinear elastic rod, where the spatiotemporal modulation is imposed as a high-frequency standing wave, supposed to be given. Finally the more...
Structure-preserving properties of three differential schemes for oscillator system
秦于越; 邓子辰; 胡伟鹏
2014-01-01
A numerical method for the Hamiltonian system is required to preserve some structure-preserving properties. The current structure-preserving method satisfies the requirements that a symplectic method can preserve the symplectic structure of a finite dimension Hamiltonian system, and a multi-symplectic method can preserve the multi-symplectic structure of an infinite dimension Hamiltonian system. In this paper, the structure-preserving properties of three differential schemes for an oscillator system are investigated in detail. Both the theoretical results and the numerical results show that the results obtained by the standard forward Euler scheme lost all the three geo-metric properties of the oscillator system, i.e., periodicity, boundedness, and total energy, the symplectic scheme can preserve the first two geometric properties of the oscillator system, and the St¨ormer-Verlet scheme can preserve the three geometric properties of the oscillator system well. In addition, the relative errors for the Hamiltonian function of the symplectic scheme increase with the increase in the step length, suggesting that the symplectic scheme possesses good structure-preserving properties only if the step length is small enough.
Statistical analysis of nonlinear dynamical systems using differential geometric sampling methods.
Calderhead, Ben; Girolami, Mark
2011-12-06
Mechanistic models based on systems of nonlinear differential equations can help provide a quantitative understanding of complex physical or biological phenomena. The use of such models to describe nonlinear interactions in molecular biology has a long history; however, it is only recently that advances in computing have allowed these models to be set within a statistical framework, further increasing their usefulness and binding modelling and experimental approaches more tightly together. A probabilistic approach to modelling allows us to quantify uncertainty in both the model parameters and the model predictions, as well as in the model hypotheses themselves. In this paper, the Bayesian approach to statistical inference is adopted and we examine the significant challenges that arise when performing inference over nonlinear ordinary differential equation models describing cell signalling pathways and enzymatic circadian control; in particular, we address the difficulties arising owing to strong nonlinear correlation structures, high dimensionality and non-identifiability of parameters. We demonstrate how recently introduced differential geometric Markov chain Monte Carlo methodology alleviates many of these issues by making proposals based on local sensitivity information, which ultimately allows us to perform effective statistical analysis. Along the way, we highlight the deep link between the sensitivity analysis of such dynamic system models and the underlying Riemannian geometry of the induced posterior probability distributions.
Solving chemical dynamic optimization problems with ranking-based differential evolution algorithms
Xu Chen; Wenli Du; Feng Qian
2016-01-01
Dynamic optimization problems (DOPs) described by differential equations are often encountered in chemical engineering. Deterministic techniques based on mathematic programming become invalid when the models are non-differentiable or explicit mathematical descriptions do not exist. Recently, evolutionary algorithms are gaining popularity for DOPs as they can be used as robust alternatives when the deterministic techniques are in-valid. In this article, a technology named ranking-based mutation operator (RMO) is presented to enhance the previous differential evolution (DE) algorithms to solve DOPs using control vector parameterization. In the RMO, better individuals have higher probabilities to produce offspring, which is helpful for the performance enhancement of DE algorithms. Three DE-RMO algorithms are designed by incorporating the RMO. The three DE-RMO algorithms and their three original DE algorithms are applied to solve four constrained DOPs from the literature. Our simulation results indicate that DE-RMO algorithms exhibit better performance than previous non-ranking DE algorithms and other four evolutionary algorithms.
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen, Geng; Schell, John Paul; Benitez, Julio Aguila; Petropoulos, Sophie; Yilmaz, Marlene; Reinius, Björn; Alekseenko, Zhanna; Shi, Leming; Hedlund, Eva; Lanner, Fredrik; Sandberg, Rickard; Deng, Qiaolin
2016-01-01
Pluripotency, differentiation, and X Chromosome inactivation (XCI) are key aspects of embryonic development. However, the underlying relationship and mechanisms among these processes remain unclear. Here, we systematically dissected these features along developmental progression using mouse embryonic stem cells (mESCs) and single-cell RNA sequencing with allelic resolution. We found that mESCs grown in a ground state 2i condition displayed transcriptomic profiles diffused from preimplantation mouse embryonic cells, whereas EpiStem cells closely resembled the post-implantation epiblast. Sex-related gene expression varied greatly across distinct developmental states. We also identified novel markers that were highly enriched in each developmental state. Moreover, we revealed that several novel pathways, including PluriNetWork and Focal Adhesion, were responsible for the delayed progression of female EpiStem cells. Importantly, we “digitalized” XCI progression using allelic expression of active and inactive X Chromosomes and surprisingly found that XCI states exhibited profound variability in each developmental state, including the 2i condition. XCI progression was not tightly synchronized with loss of pluripotency and increase of differentiation at the single-cell level, although these processes were globally correlated. In addition, highly expressed genes, including core pluripotency factors, were in general biallelically expressed. Taken together, our study sheds light on the dynamics of XCI progression and the asynchronicity between pluripotency, differentiation, and XCI. PMID:27486082
Diversity of sharp-wave-ripple LFP signatures reveals differentiated brain-wide dynamical events.
Ramirez-Villegas, Juan F; Logothetis, Nikos K; Besserve, Michel
2015-11-17
Sharp-wave-ripple (SPW-R) complexes are believed to mediate memory reactivation, transfer, and consolidation. However, their underlying neuronal dynamics at multiple scales remains poorly understood. Using concurrent hippocampal local field potential (LFP) recordings and functional MRI (fMRI), we study local changes in neuronal activity during SPW-R episodes and their brain-wide correlates. Analysis of the temporal alignment between SPW and ripple components reveals well-differentiated SPW-R subtypes in the CA1 LFP. SPW-R-triggered fMRI maps show that ripples aligned to the positive peak of their SPWs have enhanced neocortical metabolic up-regulation. In contrast, ripples occurring at the trough of their SPWs relate to weaker neocortical up-regulation and absent subcortical down-regulation, indicating differentiated involvement of neuromodulatory pathways in the ripple phenomenon mediated by long-range interactions. To our knowledge, this study provides the first evidence for the existence of SPW-R subtypes with differentiated CA1 activity and metabolic correlates in related brain areas, possibly serving different memory functions.
Diversity of sharp-wave–ripple LFP signatures reveals differentiated brain-wide dynamical events
Ramirez-Villegas, Juan F.; Logothetis, Nikos K.; Besserve, Michel
2015-01-01
Sharp-wave–ripple (SPW-R) complexes are believed to mediate memory reactivation, transfer, and consolidation. However, their underlying neuronal dynamics at multiple scales remains poorly understood. Using concurrent hippocampal local field potential (LFP) recordings and functional MRI (fMRI), we study local changes in neuronal activity during SPW-R episodes and their brain-wide correlates. Analysis of the temporal alignment between SPW and ripple components reveals well-differentiated SPW-R subtypes in the CA1 LFP. SPW-R–triggered fMRI maps show that ripples aligned to the positive peak of their SPWs have enhanced neocortical metabolic up-regulation. In contrast, ripples occurring at the trough of their SPWs relate to weaker neocortical up-regulation and absent subcortical down-regulation, indicating differentiated involvement of neuromodulatory pathways in the ripple phenomenon mediated by long-range interactions. To our knowledge, this study provides the first evidence for the existence of SPW-R subtypes with differentiated CA1 activity and metabolic correlates in related brain areas, possibly serving different memory functions. PMID:26540729
Baroux, Célia; Autran, Daphné
2015-07-01
Sexual reproduction in flowering plants offers a number of remarkable aspects to developmental biologists. First, the spore mother cells - precursors of the plant reproductive lineage - are specified late in development, as opposed to precocious germline isolation during embryogenesis in most animals. Second, unlike in most animals where meiosis directly produces gametes, plant meiosis entails the differentiation of a multicellular, haploid gametophyte, within which gametic as well as non-gametic accessory cells are formed. These observations raise the question of the factors inducing and modus operandi of cell fate transitions that originate in floral tissues and gametophytes, respectively. Cell fate transitions in the reproductive lineage imply cellular reprogramming operating at the physiological, cytological and transcriptome level, but also at the chromatin level. A number of observations point to large-scale chromatin reorganization events associated with cellular differentiation of the female spore mother cells and of the female gametes. These include a reorganization of the heterochromatin compartment, the genome-wide alteration of the histone modification landscape, and the remodeling of nucleosome composition. The dynamic expression of DNA methyltransferases and actors of small RNA pathways also suggest additional, global epigenetic alterations that remain to be characterized. Are these events a cause or a consequence of cellular differentiation, and how do they contribute to cell fate transition? Does chromatin dynamics induce competence for immediate cellular functions (meiosis, fertilization), or does it also contribute long-term effects in cellular identity and developmental competence of the reproductive lineage? This review attempts to review these fascinating questions. © 2015 The Authors The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.
The dynamic properties of the Hepatitis C Virus E2 envelope protein unraveled by molecular dynamics.
Barone, Daniela; Balasco, Nicole; Autiero, Ida; Vitagliano, Luigi
2017-03-01
Hepatitis C Virus (HCV) is one of the most persistent human viruses. Although effective therapeutic approaches have been recently discovered, their use is limited by the elevated costs. Therefore, the development of alternative/complementary strategies is an urgent need. The E2 glycoprotein, the most immunogenic HCV protein, and its variants represent natural candidates to achieve this goal. Here we report an extensive molecular dynamics (MD) analysis of the intrinsic properties of E2. Our data provide interesting clues on the global and local intrinsic dynamic features of the protein. Present MD data clearly indicate that E2 combines a flexible structure with a network of covalent bonds. Moreover, the analysis of the two most important antigenic regions of the protein provides some interesting insights into their intrinsic structural and dynamic properties. Our data indicate that a fluctuating β-hairpin represents a populated state by the region E2(412-423). Interestingly, the analysis of the epitope E2(427-446) conformation, that undergoes a remarkable rearrangement in the simulation, has significant similarities with the structure that the E2(430-442) fragment adopts in complex with a neutralizing antibody. Present data also suggest that the strict conservation of Gly436 in E2 protein of different HCV genotypes is likely dictated by structural restraints. Moreover, the analysis of the E2(412-423) flexibility provides insights into the mechanisms that some antibodies adopt to anchor Trp437 that is fully buried in E2. Finally, the present investigation suggests that MD simulations should systematically complement crystallographic studies on flexible proteins that are studied in combination with antibodies.
The structural and dynamical properties of compact elliptical galaxies
Yıldırım, Akın; van den Bosch, Remco C. E.; van de Ven, Glenn; Martín-Navarro, Ignacio; Walsh, Jonelle L.; Husemann, Bernd; Gültekin, Kayhan; Gebhardt, Karl
2017-07-01
Dedicated photometric and spectroscopic surveys have provided unambiguous evidence for a strong stellar mass-size evolution of galaxies within the last 10 Gyr. The likely progenitors of today's most massive galaxies are remarkably small, discy, passive and have already assembled much of their stellar mass at redshift z = 2. An in-depth analysis of these objects, however, is currently not feasible due to the lack of high-quality, spatially resolved photometric and spectroscopic data. In this paper, we present a sample of nearby compact elliptical galaxies (CEGs), which bear resemblance to the massive and quiescent galaxy population at earlier times. Hubble Space Telescope (HST) and wide-field integral field unit (IFU) data have been obtained, and are used to constrain orbit-based dynamical models and stellar population synthesis (SPS) fits, to unravel their structural and dynamical properties. We first show that our galaxies are outliers in the present-day stellar mass-size relation. They are, however, consistent with the mass-size relation of compact, massive and quiescent galaxies at redshift z = 2. The compact sizes of our nearby galaxies imply high central stellar mass surface densities, which are also in agreement with the massive galaxy population at higher redshift, hinting at strong dissipational processes during their formation. Corroborating evidence for a largely passive evolution within the last 10 Gyr is provided by their orbital distribution as well as their stellar populations, which are difficult to reconcile with a very active (major) merging history. This all supports that we can use nearby CEGs as local analogues of the high-redshift, massive and quiescent galaxy population, thus providing additional constraints for models of galaxy formation and evolution.
Crystal structures and dynamical properties of dense CO2.
Yong, Xue; Liu, Hanyu; Wu, Min; Yao, Yansun; Tse, John S; Dias, Ranga; Yoo, Choong-Shik
2016-10-04
Structural polymorphism in dense carbon dioxide (CO2) has attracted significant attention in high-pressure physics and chemistry for the past two decades. Here, we have performed high-pressure experiments and first-principles theoretical calculations to investigate the stability, structure, and dynamical properties of dense CO2 We found evidence that CO2-V with the 4-coordinated extended structure can be quenched to ambient pressure below 200 K-the melting temperature of CO2-I. CO2-V is a fully coordinated structure formed from a molecular solid at high pressure and recovered at ambient pressure. Apart from confirming the metastability of CO2-V (I-42d) at ambient pressure at low temperature, results of ab initio molecular dynamics and metadynamics (MD) simulations provided insights into the transformation processes and structural relationship from the molecular to the extended phases. In addition, the simulation also predicted a phase V'(Pna21) in the stability region of CO2-V with a diffraction pattern similar to that previously assigned to the CO2-V (P212121) structure. Both CO2-V and -V' are predicted to be recoverable and hard with a Vicker hardness of ∼20 GPa. Significantly, MD simulations found that the CO2 in phase IV exhibits large-amplitude bending motions at finite temperatures and high pressures. This finding helps to explain the discrepancy between earlier predicted static structures and experiments. MD simulations clearly indicate temperature effects are critical to understanding the high-pressure behaviors of dense CO2 structures-highlighting the significance of chemical kinetics associated with the transformations.
Wang, Shaoli; Wu, Jianhong; Rong, Libin
2017-06-01
Some viruses can infect different classes of cells. The age of infection can affect the dynamics of infected cells and viral production. Here we develop a viral dynamic model with the age of infection and multiple target cell populations. Using the methods of semigroup and Lyapunov function, we study the global asymptotic property of the steady states of the model. The results show that when the basic reproductive number falls below 1, the infection is predicted to die out. When the basic reproductive number exceeds 1, there exists a unique infected steady state which is globally asymptotically stable. The model can be extended to study virus dynamics with multiple compartments or coinfection by multiple types of viruses. We also show that under some scenarios the age-structured model can be reduced to an ordinary differential equation system with or without time delays.
Properties of numerical experiments in chaotic dynamical systems
Yuan, Guo-Cheng
1999-10-01
This dissertation contains four projects that I have worked on during my graduate study at University of Maryland at College Park. These projects are all related to numerical simulations of chaotic dynamical systems. In particular, the two conjectures in Chapter 1 are inspired by the numerical discoveries in Hunt and Ott [1, 2]. In Chapter 2, statistical properties of scalar transport in chaotic flows are investigated by using numerical simulations. In Chapters 3 and 4, I take a different angle and discuss the limitations of numerical simulations; i.e. for certain ``bad'' systems numerical simulations will yield incorrect or at least unreliable results no matter how many digits of precision are used. Chapter 1 discusses the properties of optimal orbits. Given a dynamical system and a function f from the state space to the real numbers, an optimal orbit for f is an orbit over which the average of f is maximal. In this chapter we discuss some basic mathematical aspects of optimal orbits: existence, sensitivity to perturbations of f, and approximability by periodic orbits with low period. For hyperbolic systems, we conjecture that (1)for (topologically) generic smooth functions, there exists an optimal periodic orbit, and (2)the optimal average can be approximated exponentially well by averages over certain periodic orbits with increasing period. In Chapter 2 we theoretically study the power spectrum of passive scalars transported in two dimensional chaotic fluid flows. Using a wave-packet method introduced by Antonsen et al. [3] [4], we numerically investigate several model flows, and confirm that the power spectrum has the k -l- scaling predicted by Batchelor [5]. In Chapter 3 we consider a class of nonhyperbolic systems, for which there are two fixed points in an attractor having a dense trajectory; the unstable manifold of one fixed point has dimension one and the other's is two dimensional. Under the condition that there exists a direction which is more expanding
Kowalski, Janina; Gan, Jian; Jonas, Peter; Pernía-Andrade, Alejandro J
2016-05-01
The hippocampus plays a key role in learning and memory. Previous studies suggested that the main types of principal neurons, dentate gyrus granule cells (GCs), CA3 pyramidal neurons, and CA1 pyramidal neurons, differ in their activity pattern, with sparse firing in GCs and more frequent firing in CA3 and CA1 pyramidal neurons. It has been assumed but never shown that such different activity may be caused by differential synaptic excitation. To test this hypothesis, we performed high-resolution whole-cell patch-clamp recordings in anesthetized rats in vivo. In contrast to previous in vitro data, both CA3 and CA1 pyramidal neurons fired action potentials spontaneously, with a frequency of ∼3-6 Hz, whereas GCs were silent. Furthermore, both CA3 and CA1 cells primarily fired in bursts. To determine the underlying mechanisms, we quantitatively assessed the frequency of spontaneous excitatory synaptic input, the passive membrane properties, and the active membrane characteristics. Surprisingly, GCs showed comparable synaptic excitation to CA3 and CA1 cells and the highest ratio of excitation versus hyperpolarizing inhibition. Thus, differential synaptic excitation is not responsible for differences in firing. Moreover, the three types of hippocampal neurons markedly differed in their passive properties. While GCs showed the most negative membrane potential, CA3 pyramidal neurons had the highest input resistance and the slowest membrane time constant. The three types of neurons also differed in the active membrane characteristics. GCs showed the highest action potential threshold, but displayed the largest gain of the input-output curves. In conclusion, our results reveal that differential firing of the three main types of hippocampal principal neurons in vivo is not primarily caused by differences in the characteristics of the synaptic input, but by the distinct properties of synaptic integration and input-output transformation.
Derry, W B; Wilson, L; Khan, I A; Luduena, R F; Jordan, M A
1997-03-25
Substoichiometric binding of taxol to tubulin in microtubules potently suppresses microtubule dynamics, which appears to be the most sensitive antiproliferative mechanism of taxol. To determine whether the beta-tubulin isotype composition of a microtubule can modulate sensitivity to taxol, we measured the effects of substoichiometric ratios of taxol bound to tubulin in microtubules on the dynamics of microtubules composed of purified alphabeta(II)-, alphabeta(III)-, or alphabeta(IV)-tubulin isotypes and compared the results with the effects of taxol on microtubules assembled from unfractionated tubulin. Substoichiometric ratios of bound taxol in microtubules assembled from purified beta-tubulin isotypes or unfractionated tubulin potently suppressed the shortening rates and the lengths shortened per shortening event. Correlation of the suppression of the shortening rate with the stoichiometry of bound taxol revealed that microtubules composed of purified alphabeta(II)-, alphabeta(III)-, and alphabeta(IV)-tubulin were, respectively, 1.6-, 7.4-, and 7.2-fold less sensitive to the effects of bound taxol than microtubules assembled from unfractionated tubulin. These results indicate that taxol differentially modulates microtubule dynamics depending upon the beta-tubulin isotype composition. The results are consistent with recent studies correlating taxol resistance in tumor cells with increased levels of beta(III0- and beta(IV)-tubulin expression and suggest that altered cellular expression of beta-tubulin isotypes can be an important mechanism by which tumor cells develop resistance to taxol.
Limit Properties of Solutions of Singular Second-Order Differential Equations
Weinmüller Ewa
2009-01-01
Full Text Available We discuss the properties of the differential equation , a.e. on , where , and satisfies the -Carathéodory conditions on for some . A full description of the asymptotic behavior for of functions satisfying the equation a.e. on is given. We also describe the structure of boundary conditions which are necessary and sufficient for to be at least in . As an application of the theory, new existence and/or uniqueness results for solutions of periodic boundary value problems are shown.
Analysis of Dynamic Properties of Piezoelectric Structure under Impact Load
Taotao Zhang
2015-10-01
Full Text Available An analytical model of the dynamic properties is established for a piezoelectric structure under impact load, without considering noise and perturbations in this paper. Based on the general theory of piezo-elasticity and impact mechanics, the theoretical solutions of the mechanical and electrical fields of the smart structure are obtained with the standing and traveling wave methods, respectively. The comparisons between the two methods have shown that the standing wave method is better for studying long-time response after an impact load. In addition, good agreements are found between the theoretical and the numerical results. To simulate the impact load, both triangle and step pulse loads are used and comparisons are given. Furthermore, the influence of several parameters is discussed so as to provide some advices for practical use. It can be seen that the proposed analytical model would benefit, to some extent, the design and application (especially the airport runway of the related smart devices by taking into account their impact load performance.
Dynamic soil properties for microzonation of Delhi, India
C Hanumantharao; G V Ramana
2008-11-01
Delhi, the capital of India, has experienced mild seismic shaking during several earthquakes in the past. The large variations of depth to bedrock and ground water table coupled with different soil types at different locations of Delhi necessitate a seismic microzonation study. Dynamic soil properties such as shear wave velocity, modulus reduction and damping characteristics of local soils are the basic and essential input parameters for conducting even a preliminary ground response analysis which is an essential input in microzonation studies. Shear wave velocity is not measured routinely due to its high cost and lack of the required expertise. Several researchers in the past developed correlations between shear wave velocity (s) and routinely measured values. In the present study, shear wave velocity profiles measured in the field at more than 80 borehole locations to a depth of about 20 to 32m using Spectral Analysis of Surface Waves (SASW) are presented and correlations between shear wave velocity and values are also presented for use by engineers and designers. Results of strain and stress controlled cyclic triaxial tests on remoulded samples of sandsilt mixtures in the high strain range are used for generating the modulus reduction and damping curves and are compared with the well-known curves in the literature. The results presented in this article can be used for microzonation studies as well as site specific ground response analyses at Delhi.
Dynamic Properties of Two-Dimensional Polydisperse Granular Gases
无
2007-01-01
We propose a two-dimensional model of polydisperse granular mixtures with a power-law size distribution in the presence of stochastic driving. A fractal dimension D is introduced as a measurement of the inhomogeneity of the size distribution of particles. We define the global and partial granular temperatures of the multi-component mixture. By direct simulation Monte Carlo, we investigate how the inhomogeneity of the size distribution influences the dynamic properties of the mixture, focusing on the granular temperature, dissipated energy, velocity distribution, spatial clusterization, and collision time. We get the following results: a single granular temperature does not characterize a multi-component mixture and each species attains its own "granular temperature"; The velocity deviation from Gaussian distribution becomes more and more pronounced and the partial density of the assembly is more inhomogeneous with the increasing value of the fractal dimension D; The global granular temperature decreases and average dissipated energy per particle increases as the value of D augments.
Mechanical properties of irradiated nanowires – A molecular dynamics study
Figueroa, Emilio [Grupo de NanoMateriales, Departamento de Física, Facultad de Ciencias, Universidad de Chile, Casilla, 653 Santiago (Chile); Departamento de Física, Facultad de Ciencias Naturales, Matemática y del Medio Ambiente, Universidad Tecnológica Metropolitana, Santiago 7800002 (Chile); Tramontina, Diego [Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, 5500 Mendoza (Argentina); Instituto de Bioingeniería, Universidad de Mendoza, 5500 Mendoza (Argentina); Gutiérrez, Gonzalo, E-mail: gonzalo@fisica.ciencias.uchile.cl [Grupo de NanoMateriales, Departamento de Física, Facultad de Ciencias, Universidad de Chile, Casilla, 653 Santiago (Chile); Bringa, Eduardo [Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, 5500 Mendoza (Argentina)
2015-12-15
In this work we study, by means of molecular dynamics simulation, the change in the mechanical properties of a gold nanowire with pre-existing radiation damage. The gold nanowire is used as a simple model for a nanofoam, made of connected nanowires. Radiation damage by keV ions leads to the formation of a stacking fault tetrahedron (SFT), and this defect leads to a reduced plastic threshold, as expected, when the nanowire is subjected to tension. We quantify dislocation and twin density during the deformation, and find that the early activation of the SFT as a dislocation source leads to reduced dislocation densities compared to the case without radiation damage. In addition, we observed a total destruction of the SFT, as opposed to a recent simulation study where it was postulated that SFTs might act as self-generating dislocation sources. The flow stress at large deformation is also found to be slightly larger for the irradiated case, in agreement with recent experiments. - Highlights: • Stacking Fault Tetrahedra (SFT) formation proceeds by cascades, containing typically a vacancy cluster and interstitials. • Applied tension leads to the destruction of the SFT, in contrast to a recently reported case of a SFT which soften the NW. • After the initial dislocation activity, strength is controlled by a few surviving dislocations.
Hypervelocity impact properties of graphene armor via molecular dynamics simulations
Wang W.
2012-08-01
Full Text Available Hypervelocity impact properties of two different graphene armor systems are investigated using molecular dynamics simulations. One system is the so-called spaced armor which consists of a number of graphene plates spaced certain distance apart. Its response under normal impact of a spherical projectile is studied, focusing on the effect of the number of graphene monolayers per plate (denoted by n on the penetration resistance of the armor. We find that under normal impact by a spherical projectile the penetration resistance increases with decreasing number of monolayers per plate (n, and the best penetration resistance is achieved in the system with one graphene layer for each plate. Note that the monolayers in all the simulated multilayer graphene plates were AB-stacked. The second system being studied is the laminated copper/graphene composites with the graphene layers inside copper, on impact or back surface, or on both the impact and back surfaces. The simulation results show that under normal impact by a spherical projectile the laminated copper/graphene composite has much higher penetration resistance than the monolithic copper plate. The best efficiency is achieved when the graphene layers are on both the impact and back surfaces.
A molecular dynamics study on surface properties of supercooled water
Lü; Yongjun
2006-01-01
[1]Basu J K,Hazra S,Sanyal M K.Growth mechanism of Langmuir-Blodgett films.Phys Rev Lett,1999,82:4675-4678[2]Taylor R S,Shields R L.Molecular-dynamics simulations of the ethanol liquid-vapor interface.J Chem Phys,2003,119:12569-12576[3]Velev O D,Gurkov T D,Ivanov I B,et al.Abnormal thickness and stability of nonequilibrium liquid films.Phys Rev Lett,1995,75:264-267[4]Weng J G,Park S,Lukes J R,et al.Molecular dynamics investigation of thickness effect on liquid films.J Chem Phys,2000,113:5917-5923[5]Zakharov V V,Brodskaya E N,Laaksonen A.Surface tension of water droplets:A molecular dynamics study of model and size dependencies.J Chem Phys,1997,107:10675-10683[6]Wang J Z,Chen M,Guo Z Y.A two-dimensional molecular dynamics simulation of liquid-vapor nucleation.Chin Sci Bull,2003,48(7):623-626[7]Guissani Y,Guillot B.A computer simulation study of the liquid-vapor coexistence curve of water.J Chem Phys,1993,98:8221-8235[8]Wilson M A,Pohorille A,Pratt L R.Surface potential of the water liquid-vapor interface.J Chem Phys,1988,88:3281-3285[9]Alejandre J,Tildesley D J,Chapela G A.Molecular dynamics simulation of the orthobaric densities and surface tension of water.J Chem Phys,1995,102:4574-4583[10]Matsumoto M,Kataoka Y.Study on liquid-vapor interface of water (Ⅰ):Simulational results of thermodynamic properties and orientational structure.J Chem Phys,1988,88:3233-3245[11]Floriano M A,Angell C A.Surface tension and molar surface free energy and entropy of water to-27.2℃.J Phys Chem,1990,94:4199-4202[12]Jorgensen W L,Chandrasekhar J,Madura J D.Comparison of simple potential functions for simulating liquid water.J Chem Phys,1993,79:926-935[13]Berendsen H J C,Grigera J R,Straatsma T P.The missing term in effective pair potentials.J Phys Chem,1987,91:6269-6271[14]Arbuckle B W,Clancy P.Effects of the Ewald sum on the free energy of the extended simple point charge model for water.J Chem Phys,2002,116:5090-5098[15]Tarazona P,Chacon E,Reinaldo-Falagan M,et al
无
2000-01-01
In this paper, to meet the needs of studying work of dynamic mechanical properties of welded joint, the dynamic mechanical properties of welded joint were measured by means of SHPB(Split Hopkinson Pressure Bar).The dynamic mechanical property's curves of every part of welded joint were obtained. For studying the dynamic behavior of mechanical heterogeneity of welded joint, important data were offered. The method of test creates a new way of studying dynamic mechanical properties of welded joint.
ZHANG Xing; BAI YongQiang; XIN Bin; CHEN Jie
2013-01-01
This paper presents online motion planning for UAV (unmanned aerial vehicle) in complex threat field,including both static threats and moving threats,which can be formulated as a dynamic constrained optimal control problem.Receding horizon control (RHC) based on differential evolution (DE) algorithm is adopted.A location-predicting model of moving threats is established to assess the value of threat that UAV faces in flight.Then flyable paths can be generated by the control inputs which are optimized by DE under the guidance of the objective function.Simulation results demonstrate that the proposed method not only generates smooth and flyable paths,but also enables UAV to avoid threats efficiently and arrive at destination safely.
Dynamic range and response speed of heat-flux differential calorimeters
Gal'Perin, L. N.
2011-08-01
A technique for the linearization of calorimeter cell (CC) thermal feedback in differential calorimeters was investigated. The technique was shown to ensure the linearity of the tract of rapid compensation measurements of thermokinetics ( W in( t)) in a dynamic range of heat-fluxes limited in principle only by the linearity of the CCs themselves, while their original identity is not required. The technique was employed in prototype models of updated DAK calorimeters, in which W in( t)max reached 0.5 W while the duration of the transition process associated with the insertion of the test specimen was reduced by a factor of 2.3. This was shown to reduce calorimeter inertia, extend the possibilities of thermokinetic measurements, and record earlier stages of the initial thermokinetics.
Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo.
Sleeman, Judith E; Trinkle-Mulcahy, Laura; Prescott, Alan R; Ogg, Stephen C; Lamond, Angus I
2003-05-15
Analysis of stable cell lines expressing fluorescently tagged survival of motor neurons protein (SMN) and coilin shows striking differences in their dynamic behaviour, both in the nucleus and during mitosis. Cajal bodies labelled with either FP-SMN or FP-coilin show similar behaviour and frequency of movements. However, fluorescence recovery after photobleaching (FRAP) studies show that SMN returns approximately 50-fold more slowly to Cajal bodies than does coilin. Time-lapse studies on cells progressing from prophase through to G1 show further differences between SMN and coilin, both in their localisation in telophase and in the timing of their re-entry into daughter nuclei. The data reveal similarities between Cajal bodies and nucleoli in their behaviour during mitosis. This in vivo study indicates that SMN and coilin interact differentially with Cajal bodies and reveals parallels in the pathway for reassembly of nucleoli and Cajal bodies following mitosis.
Influence of the sterol aliphatic side chain on membrane properties: a molecular dynamics study.
Robalo, João R; Ramalho, J P Prates; Huster, Daniel; Loura, Luís M S
2015-09-21
Following a recent experimental investigation of the effect of the length of the alkyl side chain in a series of cholesterol analogues (Angew. Chem., Int. Ed., 2013, 52, 12848-12851), we report here an atomistic molecular dynamics characterization of the behaviour of methyl-branched side chain sterols (iso series) in POPC bilayers. The studied sterols included androstenol (i-C0-sterol) and cholesterol (i-C8-sterol), as well as four other derivatives (i-C5, i-C10, i-C12 and i-C14-sterol). For each sterol, both subtle local effects and more substantial differential alterations of membrane properties along the iso series were investigated. The location and orientation of the tetracyclic ring system is almost identical in all compounds. Among all the studied sterols, cholesterol is the sterol that presents the best matching with the hydrophobic length of POPC acyl chains, whereas longer-chained sterols interdigitate into the opposing membrane leaflet. In accordance with the experimental observations, a maximal ordering effect is observed for intermediate sterol chain length (i-C5, cholesterol, i-C10). Only for these sterols a preferential interaction with the saturated sn-1 chain of POPC (compared to the unsaturated sn-2 chain) was observed, but not for either shorter or longer-chained derivatives. This work highlights the importance of the sterol alkyl chain in the modulation of membrane properties and lateral organization in biological membranes.
Liu, Chang; Le Blanc, J C Yves; Schneider, Bradley B; Shields, Jefry; Federico, James J; Zhang, Hui; Stroh, Justin G; Kauffman, Gregory W; Kung, Daniel W; Ieritano, Christian; Shepherdson, Evan; Verbuyst, Mitch; Melo, Luke; Hasan, Moaraj; Naser, Dalia; Janiszewski, John S; Hopkins, W Scott; Campbell, J Larry
2017-02-22
The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong local hydrogen bonding exists between the molecule and the solvent. One method that can probe the microsolvated states of charged molecules is differential mobility spectrometry (DMS), which rapidly interrogates an ion's transitions between a solvated and desolvated state in the gas phase (i.e., few solvent molecules present). However, can the results of DMS analyses of a class of molecules reveal information about the bulk physicochemical properties of those species? Our findings presented here show that DMS behaviors correlate strongly with the measured solution phase pKa and pKb values, and cell permeabilities of a set of structurally related drug molecules, even yielding high-resolution discrimination between isomeric forms of these drugs. This is due to DMS's ability to separate species based upon only subtle (yet predictable) changes in structure: the same subtle changes that can influence isomers' different bulk properties. Using 2-methylquinolin-8-ol as the core structure, we demonstrate how DMS shows promise for rapidly and sensitively probing the physicochemical properties of molecules, with particular attention paid to drug candidates at the early stage of drug development. This study serves as a foundation upon which future drug molecules of different structural classes could be examined.
Extending the dynamic range of the ion trap by differential mobility filtration.
Hall, Adam B; Coy, Stephen L; Kafle, Amol; Glick, James; Nazarov, Erkinjon; Vouros, Paul
2013-09-01
A miniature, planar, differential ion mobility spectrometer (DMS) was interfaced to an LCQ classic ion trap to conduct selective ion filtration prior to mass analysis in order to extend the dynamic range of the trap. Space charge effects are known to limit the functional ion storage capacity of ion trap mass analyzers and this, in turn, can affect the quality of the mass spectral data generated. This problem is further exacerbated in the analysis of mixtures where the indiscriminate introduction of matrix ions results in premature trap saturation with non-targeted species, thereby reducing the number of parent ions that may be used to conduct MS/MS experiments for quantitation or other diagnostic studies. We show that conducting differential mobility-based separations prior to mass analysis allows the isolation of targeted analytes from electrosprayed mixtures preventing the indiscriminate introduction of matrix ions and premature trap saturation with analytically unrelated species. Coupling these two analytical techniques is shown to enhance the detection of a targeted drug metabolite from a biological matrix. In its capacity as a selective ion filter, the DMS can improve the analytical performance of analyzers such as quadrupole (3D or linear) and ion cyclotron resonance (FT-ICR) ion traps that depend on ion accumulation.
Correct block artifacts by differential projection for a dynamic computed tomography system
Xiao, Yongshun; Han, Fangda; Chen, Zhiqiang
2017-09-01
In the aero-engine industry, it is important to carry out regular and effective tests on engines in service. However, current detection methods often have problems such as a limitation on materials characteristics or geometry structures. Recently, a novel dynamic computed tomography (CT) system was proposed to provide highly efficient CT inspection for rotating parts, in particular the blades of aero-engines in operation. However, one problem exists in the proposed system in that some components remain static when the engine is in operation. These static parts will appear as strip artifacts in projection and ultimately as ring artifacts in the reconstructed image, which are called block artifacts. In this paper, we put forward a differential projection correction method to correct block artifacts and reconstruct the blades of the aero-engine. The method makes use of the distribution of the blades and the static parts to remove the artifacts. The experiment results show that the proposed method can effectively remove the block artifacts while maintaining the grayscale and geometry structure of the blades, furthermore, we also verify its ability to detect defects using numerical experiments. The differential projection correction method makes the system more practicable for in situ inspection of aero-engines.
Extending the Dynamic Range of the Ion Trap by Differential Mobility Filtration
Hall, Adam B.; Coy, Stephen L.; Kafle, Amol; Glick, James; Nazarov, Erkinjon
2013-01-01
A miniature, planar, differential ion mobility spectrometer (DMS) was interfaced to an LCQ classic ion trap to conduct selective ion filtration prior to mass analysis in order to extend the dynamic range of the trap. Space charge effects are known to limit the functional ion storage capacity of ion trap mass analyzers and this, in turn, can affect the quality of the mass spectral data generated. This problem is further exacerbated in the analysis of mixtures where the indiscriminate introduction of matrix ions results in premature trap saturation with non-targeted species, thereby reducing the number of parent ions that may be used to conduct MS/MS experiments for quantitation or other diagnostic studies. We show that conducting differential mobility-based separations prior to mass analysis allows the isolation of targeted analytes from electrosprayed mixtures preventing the indiscriminate introduction of matrix ions and premature trap saturation with analytically unrelated species. Coupling these two analytical techniques is shown to enhance the detection of a targeted drug metabolite from a biological matrix. In its capacity as a selective ion filter, the DMS can improve the analytical performance of analyzers such as quadrupole (3-D or linear) and ion cyclotron resonance (FT-ICR) ion traps that depend on ion accumulation. PMID:23797861
Prostatic Cancer： Diagnosis and Differentiation by Dynamic Contrast-Enhanced MRI
SHIHao; DINGHongyu; ZHANGGuangying; YANGZhenzhen
2005-01-01
Objective: To assess the role of dynamic contrast-enhanced MRI (DCE-MRI) in the diagnosis and differentiation of prostatic cancer (PC). Methods: Five volunteers, 36 patients with benign prostatic hyperplasia (BPH) and 13 patients with biopsy-proven prostate cancer underwent conventional MRI, DCE-MR1 and delayed enhancement MRI. The value of the signal intensity in DCE-MRI was measured and calculated to draw the time-signal intensity curve of the normal peripheral zone (PZ), the prostate cancer and the benign prostatic hyperplasia. Results: In DCE-MRI, the normal peripheral zone was enhanced mildly and slowly and the peak value was located in late phase. The enhancement of the lesions in 36 patients with the benign prostatic hyperplasia was obvious in early phase and strengthened gradually, and then turned to decrease in late phase after peak value. The lesions in 9 of 13 cases with prostate cancer were enhanced obviously in early phase and washed out rapidly, and the peak value was located in early phase, but the peak value was in mediate and late phase in the other 4 cases with diffuse lesion in the prostate on T2WI. Conclusion: In DCE-MRI, the enhancement patterns of the normal peripheral zone,the prostate cancer and the benign prostatic hyperplasia were significantly different. DCE-MRI was very useful in the diagnosis and differentiation of prostate cancer.
Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations.
Mehere, Prajwalini; Han, Qian; Lemkul, Justin A; Vavricka, Christopher J; Robinson, Howard; Bevan, David R; Li, Jianyong
2010-11-01
Tyrosine aminotransferase (TAT) catalyzes the transamination of tyrosine and other aromatic amino acids. The enzyme is thought to play a role in tyrosinemia type II, hepatitis and hepatic carcinoma recovery. The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases. Mouse TAT (mTAT) was cloned from a mouse cDNA library, and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques. The recombinant mTAT is able to catalyze the transamination of tyrosine using α-ketoglutaric acid as an amino group acceptor at neutral pH. The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxy-phenylpyruvate, phenylpyruvate and alpha-ketocaproic acid as amino group acceptors. Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9 Å resolution. The crystal structure revealed the interaction between the pyridoxal-5'-phosphate cofactor and the enzyme, as well as the formation of a disulphide bond. The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent. Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity. The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation.
Tyrosine Aminotransferase: Biochemical and Structural Properties and Molecular Dynamics Simulations
P Mehere; Q Han; J Lemkul; C Vavricka; H Robinson; D Bevan; J Li
2011-12-31
Tyrosine aminotransferase (TAT) catalyzes the transamination of tyrosine and other aromatic amino acids. The enzyme is thought to play a role in tyrosinemia type II, hepatitis and hepatic carcinoma recovery. The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases. Mouse TAT (mTAT) was cloned from a mouse cDNA library, and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques. The recombinant mTAT is able to catalyze the transamination of tyrosine using {alpha}-ketoglutaric acid as an amino group acceptor at neutral pH. The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxy-phenylpyruvate, phenylpyruvate and alpha-ketocaproic acid as amino group acceptors. Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9 {angstrom} resolution. The crystal structure revealed the interaction between the pyridoxal-5'-phosphate cofactor and the enzyme, as well as the formation of a disulphide bond. The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent. Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity. The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation.
Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations
Mehere, P.; Robinson, H.; Han, Q.; Lemkul, J. A.; Vavricka, C. J.; Bevan, D. R.; Li, J.
2010-11-01
Tyrosine aminotransferase (TAT) catalyzes the transamination of tyrosine and other aromatic amino acids. The enzyme is thought to play a role in tyrosinemia type II, hepatitis and hepatic carcinoma recovery. The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases. Mouse TAT (mTAT) was cloned from a mouse cDNA library, and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques. The recombinant mTAT is able to catalyze the transamination of tyrosine using {alpha}-ketoglutaric acid as an amino group acceptor at neutral pH. The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxy-phenylpyruvate, phenylpyruvate and alpha-ketocaproic acid as amino group acceptors. Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9 {angstrom} resolution. The crystal structure revealed the interaction between the pyridoxal-5'-phosphate cofactor and the enzyme, as well as the formation of a disulphide bond. The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent. Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity. The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation.
Rigatos, Gerasimos
2016-12-01
It is shown that the model of the hypothalamic-pituitary-adrenal gland axis is a differentially flat one and this permits to transform it to the so-called linear canonical form. For the new description of the system's dynamics the transformed control inputs contain unknown terms which depend on the system's parameters. To identify these terms an adaptive fuzzy approximator is used in the control loop. Thus an adaptive fuzzy control scheme is implemented in which the unknown or unmodeled system dynamics is approximated by neurofuzzy networks and next this information is used by a feedback controller that makes the state variables (CRH - corticotropin releasing hormone, adenocortocotropic hormone - ACTH, cortisol) of the hypothalamic-pituitary-adrenal gland axis model converge to the desirable levels (setpoints). This adaptive control scheme is exclusively implemented with the use of output feedback, while the state vector elements which are not directly measured are estimated with the use of a state observer that operates in the control loop. The learning rate of the adaptive fuzzy system is suitably computed from Lyapunov analysis, so as to assure that both the learning procedure for the unknown system's parameters, the dynamics of the observer and the dynamics of the control loop will remain stable. The performed Lyapunov stability analysis depends on two Riccati equations, one associated with the feedback controller and one associated with the state observer. Finally, it is proven that for the control scheme that comprises the feedback controller, the state observer and the neurofuzzy approximator, an H-infinity tracking performance can be succeeded.
The dynamics of the HIV infection: a time-delay differential equation approach
Bacelar, Flora S; Santos, Rita M Zorzenon dos
2010-01-01
In this work we introduce a differential equation model with time-delay that describes the three-stage dynamics and the two time scales observed in HIV infection. Assuming that the virus has high mutation and rapid reproduction rates that stress the immune system throughout the successive activation of new responses to new undetectable strains, the delay term describes the time interval necessary to mount new specific immune responses. This single term increases the number of possible solutions and changes the phase space dynamics if compared to the model without time delay. We observe very slow transits near the unstable fixed point, corresponding to a healthy state, and long time decay to the stable fixed point that corresponds to the infected state. In contrast to the results obtained for models using regular ODE, which only allow for partial descriptions of the course of the infection, our model describes the entire course of infection observed in infected patients: the primary infection, the latency peri...
Dynamics of DNA methylation and Histone H4 acetylation during floral bud differentiation in azalea
Valledor Luis
2010-01-01
Full Text Available Abstract Background The ability to control the timing of flowering is a key strategy for planning production in ornamental species such as azalea, however it requires a thorough understanding of floral transition. Floral transition is achieved through a complex genetic network and regulated by multiple environmental and endogenous cues. Dynamic changes between chromatin states facilitating or inhibiting DNA transcription regulate the expression of floral induction pathways in response to environmental and developmental signals. DNA methylation and histone modifications are involved in controlling the functional state of chromatin and gene expression. Results The results of this work indicate that epigenetic mechanisms such as DNA methylation and histone H4 acetylation have opposite and particular dynamics during the transition from vegetative to reproductive development in the apical shoots of azalea. Global levels of DNA methylation and histone H4 acetylation as well as immunodetection of 5-mdC and acetylated H4, in addition to a morphological study have permitted the delimitation of four basic phases in the development of the azalea bud and allowed the identification of a stage of epigenetic reprogramming which showed a sharp decrease of whole DNA methylation similar to that is defined in other developmental processes in plants and in mammals. Conclusion The epigenetic control and reorganization of chromatin seem to be decisive for coordinating floral development in azalea. DNA methylation and H4 deacetylation act simultaneously and co-ordinately, restructuring the chromatin and regulating the gene expression during soot apical meristem development and floral differentiation.
Charalambous, Charalambos D.; Ahmed, Nasir U.
2013-01-01
In this paper, we present two methods which generalize static team theory to dynamic team theory, in the context of continuous-time stochastic nonlinear differential decentralized decision systems, with relaxed strategies, which are measurable to different noisy information structures. For both methods we apply Girsanov's measure transformation to obtain an equivalent dynamic team problem under a reference probability measure, so that the observations and information structures available for ...
无
2000-01-01
This note contains three main results.Firstly,a complete solution of the Linear Non-Homogeneous Matrix Differential Equations (LNHMDEs) is presented that takes into account both the non-zero initial conditions of the pseudo state and the nonzero initial conditions of the input.Secondly,in order to characterise the dynamics of the LNHMDEs correctly,some important concepts such as the state,slow state (smooth state) and fast state (impulsive state) are generalized to the LNHMDE case and the solution of the LNHMDEs is separated into the smooth (slow) response and the fast (implusive) response.As a third result,a new characterization of the impulsive free initial conditions of the LNHMDEs is given.
Chou, M.Y.
1992-04-01
This report discusses the following topics: calculation of the Structural Properties of Yttrium; dynamical and pairing properties of {alpha}-YH{chi}; electronic and structural properties of YH{sub 2} and YH{sub 3}; phase diagram of hydrogen on Ru(000); peierls distortion in hexagonal YH{sub 3}; and study of hydrogen in niobium and palladium.
Differentiation of breast cancer from fibroadenoma with dual-echo dynamic contrast-enhanced MRI.
Shiwei Wang
Full Text Available Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI of the breast is a routinely used imaging method which is highly sensitive for detecting breast malignancy. Specificity, though, remains suboptimal. Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI, an alternative dynamic contrast imaging technique, evaluates perfusion-related parameters unique from DCE MRI. Previous work has shown that the combination of DSC MRI with DCE MRI can improve diagnostic specificity, though an additional administration of intravenous contrast is required. Dual-echo MRI can measure both T1W DCE MRI and T2*W DSC MRI parameters with a single contrast bolus, but has not been previously implemented in breast imaging. We have developed a dual-echo gradient-echo sequence to perform such simultaneous measurements in the breast, and use it to calculate the semi-quantitative T1W and T2*W related parameters such as peak enhancement ratio, time of maximal enhancement, regional blood flow, and regional blood volume in 20 malignant lesions and 10 benign fibroadenomas in 38 patients. Imaging parameters were compared to surgical or biopsy obtained tissue samples. Receiver operating characteristic (ROC curves and area under the ROC curves were calculated for each parameter and combination of parameters. The time of maximal enhancement derived from DCE MRI had a 90% sensitivity and 69% specificity for predicting malignancy. When combined with DSC MRI derived regional blood flow and volume parameters, sensitivity remained unchanged at 90% but specificity increased to 80%. In conclusion, we show that dual-echo MRI with a single administration of contrast agent can simultaneously measure both T1W and T2*W related perfusion and kinetic parameters in the breast and the combination of DCE MRI and DSC MRI parameters improves the diagnostic performance of breast MRI to differentiate breast cancer from benign fibroadenomas.
Jeongah Yoon
Full Text Available Cell growth critically depends on signalling pathways whose regulation is the focus of intense research. Without utilizing a priori knowledge of the relative importance of pathway components, we have applied in silico computational methods to the EGF-induced MAPK cascade. Specifically, we systematically perturbed the entire parameter space, including initial conditions, using a Monte Carlo approach, and investigate which protein components or kinetic reaction steps contribute to the differentiation of ERK responses. The model, based on previous work by Brightman and Fell (2000, is composed of 28 reactions, 27 protein molecules, and 48 parameters from both mass action and Michaelis-Menten kinetics. Our multi-parametric systems analysis confirms that Raf inactivation is one of the key steps regulating ERK responses to be either transient or sustained. Furthermore, the results of amplitude-differential ERK phosphorylations within the transient case are mainly attributed to the balance between activation and inactivation of Ras while duration-differential ERK responses for the sustained case are, in addition to Ras, markedly affected by dephospho-/phosphorylation of both MEK and ERK. Our sub-module perturbations showed that MEK and ERK's contribution to this differential ERK activation originates from fluctuations in intermediate pathway module components such as Ras and Raf, implicating a cooperative regulatory mode among the key components. The initial protein concentrations of corresponding reactions such as Ras, GAP, and Raf also influence the distinct signalling outputs of ERK activation. We then compare these results with those obtained from a single-parametric perturbation approach using an overall state sensitivity (OSS analysis. The OSS findings indicate a more pronounced role of ERK's inhibitory feedback effect on catalysing the dissociation of the SOS complex. Both approaches reveal the presence of multiple specific reactions involved in
Yu, Y.; Lu, M.; Chen, M. H.; Wang, L. S.; Bu, Z. X.; Song, G.; Sun, L.
2016-11-01
Owing to their high aspect ratio, large specific surface area, high axial Young's modulus/strength, and low density, one dimensional carbon nanomaterials can introduce significant change to the mechanical properties of polymer matrices, both static and dynamic. Thus, one of the most important potential applications of carbon nanotubes or nanofibers is to utilize the enhanced dynamic damping properties of polymer nanocomposites for improved vibration, acoustic, and fatigue performances. This study focuses on calculating the nanocomposite energy dissipation under dynamic mechanical loading. A micromechanical model based on quasi-static stick-slip analysis has been developed to quantify the dynamic mechanical properties of the nanocomposites as a function of external strain in the elastic region. Storage and loss moduli are used to characterize such dynamic mechanical behaviors. Influences of nanotube bundling and nanotube alignment on the damping property of composites have been quantified. Simulation results are in good agreement with the reported experimental measurements.
Parniakov, Oleksii; Bals, Olivier; Barba, Francisco J; Mykhailyk, Viacheslav; Lebovka, Nikolai; Vorobiev, Eugene
2016-05-31
Over the last years, both food researchers and food industry have shown an increased interest in finding techniques that can estimate the modifications in quality, nutritional and thermophysical properties of food products during processing and/or storage. For instance, differential scanning calorimetry (DSC) has attracted the interest of the scientific community because only a small amount of sample is needed for the analysis. Moreover, it does not require any specific sample preparation and it is a repeatable and reliable method. In addition, DSC methodology needs a short time of experiments compared to other techniques used for the same purpose. At this stage of investigation, there is a need to evaluate the commonly accepted and new emerging DSC applications in order to establish the optimum conditions of emerging processing. This paper reviews the current and new insights of DSC technique for the estimation of quality, nutritional and thermophysical properties of food products during conventional and emerging processing and/or subsequent storage. The estimation of the different properties in several food matrices after processing and/or storage is also discussed.
Roberts Jason A
2006-01-01
Full Text Available We consider the reliability of some numerical methods in preserving the stability properties of the linear stochastic functional differential equation , where α, β, σ, τ ≥ 0 are real constants, and W(t is a standard Wiener process. The areas of the regions of asymptotic stability for the class of methods considered, indicated by the sufficient conditions for the discrete system, are shown to be equal in size to each other and we show that an upper bound can be put on the time-step parameter for the numerical method for which the system is asymptotically mean-square stable. We illustrate our results by means of numerical experiments and various stability diagrams. We examine the extent to which the continuous system can tolerate stochastic perturbations before losing its stability properties and we illustrate how one may accurately choose a numerical method to preserve the stability properties of the original problem in the numerical solution. Our numerical experiments also indicate that the quality of the sufficient conditions is very high.
Khani, Mohammad-Mehdi; Tafazzoli-Shadpour, Mohammad; Rostami, Mostafa; Peirovi, Habibollah; Janmaleki, Mohsen
2014-07-01
Human mesenchymal stem cells (hMSCs) are multipotent cells appropriate for a variety of tissue engineering and cell therapy applications. Mechanical properties of hMSCs during differentiation are associated with their particular metabolic activity and regulate cell function due to alternations in cytoskeleton and structural elements. The objective of this study is to evaluate elastic and viscoelastic properties of hMSCs during long term cultivation in control and transforming growth factor-β1 treatment groups using micropipette aspiration technique. The mean Young's modulus (E) of the control samples remained nearly unchanged during 6 days of cultivation, but that of the test samples showed an initial reduction compared to its relevant control sample after 2 days of treatment by biological growth factor, followed by a significant rise after 4 and 6 days. The viscoelastic creep tests showed that both instantaneous and equilibrium moduli significantly increased with the treatment time and reached to maximum values of 622.9 ± 114.2 and 144.3 ± 11.6 Pa at the sixth day, respectively, while increase in apparent viscosity was not statistically significant. Such change of mechanical properties of hMSCs during specific lineage commitment contributes to regenerative medicine as well as stem-cell-based therapy in which biophysical signals regulate stem cell fate.
Visualizing global properties of a molecular dynamics trajectory.
Zhou, Hao; Li, Shangyang; Makowski, Lee
2016-01-01
Molecular dynamics (MD) trajectories are very large data sets that contain substantial information about the dynamic behavior of a protein. Condensing these data into a form that can provide intuitively useful understanding of the molecular behavior during the trajectory is a substantial challenge that has received relatively little attention. Here, we introduce the sigma-r plot, a plot of the standard deviation of intermolecular distances as a function of that distance. This representation of global dynamics contains within a single, one-dimensional plot, the average range of motion between pairs of atoms within a macromolecule. Comparison of sigma-r plots calculated from 10 ns trajectories of proteins representing the four major SCOP fold classes indicates diversity of dynamic behaviors which are recognizably different among the four classes. Differences in domain structure and molecular weight also produce recognizable features in sigma-r plots, reflective of differences in global dynamics. Plots generated from trajectories with progressively increasing simulation time reflect the increased sampling of the structural ensemble as a function of time. Single amino acid replacements can give rise to changes in global dynamics detectable through comparison of sigma-r plots. Dynamic behavior of substructures can be monitored by careful choice of interatomic vectors included in the calculation. These examples provide demonstrations of the utility of the sigma-r plot to provide a simple measure of the global dynamics of a macromolecule.
States of change: Explaining dynamics by anticipatory state properties
Treur, J.
2008-01-01
In Cognitive Science, recently Dynamical Systems Theory (DST) has been advocated as an approach to cognitive modelling that is better suited to the dynamics of cognitive processes than the symbolic/computational approaches are. Often the differences between DST and the symbolic/computational approac
Alemany, Manuel M. G. [Universidad de Santiago de Compostela; Longo, Roberto [Universidad de Santiago de Compostela; Gallego, Luis [Universidad de Santiago de Compostela; Gonzales, D. J. [Universidad de Valladolid; Gonzales, L. E. [Universidad de Valladolid; Tiago, Murilo L [ORNL; Chelikowsky, James [University of Texas, Austin
2007-01-01
We performed a comprehensive study of the static, dynamic and electronic properties of liquid Pb at T = 650 kelvins, density 0.0309 angstroms^{-3} by means of 216-particle ab initio molecular dynamics simulations based on a real-space implementation of pseudopotentials constructed within density-functional theory. The predicted results and available experimental data are very in good agreement, which confirms the adequacy of this technique to achieve a reliable description of the behavior of liquid metals, including their dynamic properties. Although some of the computed properties of liquid Pb are similar to those of simple liquid metals, others differ markedly. Our results show that an appropriate description of liquid Pb requires the inclusion of relativistic effects in the determination of the pseudopotentials of Pb.
Lerbret, A; Affouard, F; Hedoux, A; Guinet, Y; Descamps, M
2007-01-01
The influence of three well-known disaccharides, namely trehalose, maltose and sucrose, on some structural and dynamical properties of lysozyme has been investigated by means of molecular dynamics computer simulations in the 37-60 wt % concentration range. The effects of sugars on the protein conformation are found relatively weak, in agreement with the preferential hydration of lysozyme. Conversely, sugars seem to increase significantly the relaxation times of the protein. These effects are shown to be correlated to the fractional solvent accessibilities of lysozyme residues and further support the slaving of protein dynamics. Moreover, a significant increase in the relaxation times of lysozyme, sugars and water molecules is observed within the studied concentration range and may result from the percolation of the hydrogen-bond network of sugar molecules. This percolation appears to be of primary importance to explain the influence of sugars on the dynamical properties of lysozyme and water.
Ab-initio study of several static and dynamic properties of liquid palladium and platinum
González L. E.
2017-01-01
Full Text Available We report a study on several static and dynamic properties of liquid Pd and Pt metals at thermodynamic conditions near their respective triple points. The calculations have been carried out by an ab initio molecular dynamics simulation technique. Results are reported for several static structural magnitudes which are compared with the available X-ray diffraction. As for the dynamic properties, results have been obtained for both single and collective dynamical magnitudes as well as for some transport coeffcients which are compared with the corresponding experimental data.
Chen, Hongfeng; Titushkin, Igor; Stroscio, Michael; Cho, Michael
2007-02-15
Functionalized quantum dots offer several advantages for tracking the motion of individual molecules on the cell surface, including selective binding, precise optical identification of cell surface molecules, and detailed examination of the molecular motion without photobleaching. We have used quantum dots conjugated with integrin antibodies and performed studies to quantitatively demonstrate changes in the integrin dynamics during osteogenic differentiation of human bone marrow derived progenitor cells (BMPCs). Consistent with the unusually strong BMPC adhesion previously observed, integrins on the surface of undifferentiated BMPC were found in clusters and the lateral diffusion was slow (e.g., approximately 10(-11) cm2/s). At times as early as those after a 3-day incubation in the osteogenic differentiation media, the integrin diffusion coefficients increased by an order of magnitude, and the integrin dynamics became indistinguishable from that measured on the surface of terminally differentiated human osteoblasts. Furthermore, microfilaments in BMPCs consisted of atypically thick bundles of stress fibers that were responsible for restricting the integrin lateral mobility. Studies using laser optical tweezers showed that, unlike fully differentiated osteoblasts, the BMPC cytoskeleton is weakly associated with its cell membrane. Based on these findings, it appears likely that the altered integrin dynamics is correlated with BMPC differentiation and that the integrin lateral mobility is restricted by direct links to microfilaments.
Achiam, M P; Andersen, L P H; Klein, M
2010-01-01
Colorectal cancer will present itself as a bowel obstruction in 16-23% of all cases. However, not all obstructing tumors are malignant and the differentiation between a benign and a malignant tumor can be difficult. The purpose of our study was to determine whether fast dynamic gadolinium...
Arisaka, Yoshinori; Nishijima, Yuka; Yusa, Shin-Ichi; Takeda, Naoya
2016-09-01
We designed photo-crosslinkable polymer brushes with dimethylmaleimide moieties, in order to demonstrate dynamic stimulation of cell differentiation in mesenchymal stem cells (MSCs). The polymer brushes were synthesized by surface-initiated reversible addition fragmentation chain transfer polymerization using dimethylmaleimide ethyl methacrylate and methyl methacrylate on a chain transfer agent-immobilized glass surface. The polymer brushes were crosslinked by photodimerization of the dimethylmaleimide moieties within polymer chains with stem cells present on the surface. In order to evaluate the effects of in situ photo-induced crosslinking of the polymer brushes on gene expression of stem cells, human bone marrow MSCs were cultured under static and dynamic culture conditions for 7 days. Expression of the osteocalcin (Ocn) gene in MSCs was used as an indicator of osteoblast differentiation under dynamic culture conditions. Structural conversion from non-crosslinked polymer brushes to crosslinked polymer brushes increased the expression of Ocn by 1.4-fold in the presence of adhered cells, compared with non-crosslinked polymer brushes under static culture conditions. These results suggest that MSCs recognized surface conversion from non-crosslinked to crosslinked structures, which resulted in altered differentiation lineages. Therefore, photo-crosslinkable surfaces with dimethyl maleimide moieties are potential novel materials for dynamically stimulating MSC differentiation.
ASYMPTOTIC STABILITY PROPERTIES OF θ-METHODS FOR THE MULTI-PANTOGRAPH DELAY DIFFERENTIAL EQUATION
Dong-song Li; Ming-zhu Liu
2004-01-01
This paper deals with the asymptotic stability analysis of θ - methods for multi-pantograph delay differential equation u'(t)=λu(t)+lΣi=1μiu(qit),0＜ql＜ql-1＜…＜ql＜1,/u(0)=u0.Here λ,μ1,…,μl,u0∈C.In recent years stability properties of numerical methods for this kind of equation has been studied by numerous authors. Many papers are concerned with meshes with fixed stepsize. In general the developed techniques give rise to non-ordinary recurrence relation. In this work, instead, we study constrained variable stpesize schemes, suggested by theoretical and computational reasons, which lead to a non-stationary difference equation.A general theorem is presented which can be used to obtain the characterization of the stability regions of θ - methods.
Symplectic Covariance Properties for Shubin and Born-Jordan Pseudo-Differential Operators
de Gosson, Maurice A
2011-01-01
Among all classes of pseudo-differential operators only the Weyl operators enjoy the property of symplectic covariance with respect to conjugation by elements of the metaplectic group. In this paper we show that there is, however, a weaker form of symplectic covariance for Shubin's {\\tau}-dependent operators, in which the intertwiners no longer are metaplectic, but still are invertible non-unitary operators. We also study the case of Born--Jordan operators, which are obtained by averaging the {\\tau}-operators over the interval [0,1] (such operators have recently been studied by Boggiatto and his collaborators). We show that metaplectic covariance still hold for these operators, with respect top a subgroup of the metaplectic group.
Khachfe, Hassan M; Atkinson, David
2013-04-01
Thermal and stability properties of B17, the 17% N-terminal domain of apo B, were carried out using differential scanning calorimetry spectroscopy, where the thermal characteristics of the polypeptide were studied and analyzed. The heat capacity data of B17 showed that the protein undergoes two transitions between 50 and 90 °C, with T m's at 65.9 and 74.8 °C. While the first transition showed immediate reversibility, the second one-with the higher T m-necessitated a longer cooling (several days) period for its reversibility to be observed and both transitions could be seen in the heat capacity profile of B17. Moreover, the van't Hoff enthalpies determined via calorimetric measurements agreed with the values calculated from the CD analysis reported previously.
Antonova, Irina V.; Kurkina, Irina I.; Nebogatikova, Nadezhda A.; Komonov, Alexander I.; Smagulova, Svetlana A.
2017-02-01
The band structure and electric properties of films created from a partially fluorinated graphene suspension are analyzed in this paper. As may be inferred from the structural study, graphene islands (quantum dots) are formed in these films. Various types of negative differential resistance (NDR) and a step-like increase in the current are found for films created from the fluorinated graphene suspension. NDR resulting from the formation of the potential barrier system in the film and corresponding to the theoretical prediction is observed for a relatively low fluorination degree. The origin of the NDR varies with an increase in the fluorination degree of the suspension. The observation of NDR in the fluorinated films widens the range of application of such films, including as active device layers fabricated using 2D printed technologies on rigid and flexible substrates.
Fuquan Jiang
2013-01-01
Full Text Available We consider the properties of Green’s function for the nonlinear fractional differential equation boundary value problem: D0+αu(t+f(t,u(t+e(t=0,0
The electric properties and the current-controlled differential negative resistance of cBN crystal
2008-01-01
The electric properties of nonintentionally doped n-cubic boron nitride(cBN) crystal are investigated.The cBN crystal was transformed from hexagonal-boron nitride(h-BN) under high pressure(HP) and high temperature(HT) using magnesium powder as catalyst.At room temperature,the current-voltage(I-V) characteristics of cBN crystal are measured and found to be nonlinear.When the electric field is in the range of(1―1.5)×105 V/cm,the avalanche breakdown occurs inside the whole cBN crystal.At this same time,the bright blue-violet with the wavelength of 380―400 nm from the cBN crystal is observed.When measuring the I-V curve after breakdown of cBN crystal,the current-controlled differential negative resistance phenomenon is observed.The breakdown is repeatable.
Differential kinetic dynamics and heating of ions in the turbulent solar wind
Valentini, F.; Perrone, D.; Stabile, S.; Pezzi, O.; Servidio, S.; De Marco, R.; Marcucci, F.; Bruno, R.; Lavraud, B.; De Keyser, J.; Consolini, G.; Brienza, D.; Sorriso-Valvo, L.; Retinò, A.; Vaivads, A.; Salatti, M.; Veltri, P.
2016-12-01
The solar wind plasma is a fully ionized and turbulent gas ejected by the outer layers of the solar corona at very high speed, mainly composed by protons and electrons, with a small percentage of helium nuclei and a significantly lower abundance of heavier ions. Since particle collisions are practically negligible, the solar wind is typically not in a state of thermodynamic equilibrium. Such a complex system must be described through self-consistent and fully nonlinear models, taking into account its multi-species composition and turbulence. We use a kinetic hybrid Vlasov-Maxwell numerical code to reproduce the turbulent energy cascade down to ion kinetic scales, in typical conditions of the uncontaminated solar wind plasma, with the aim of exploring the differential kinetic dynamics of the dominant ion species, namely protons and alpha particles. We show that the response of different species to the fluctuating electromagnetic fields is different. In particular, a significant differential heating of alphas with respect to protons is observed. Interestingly, the preferential heating process occurs in spatial regions nearby the peaks of ion vorticity and where strong deviations from thermodynamic equilibrium are recovered. Moreover, by feeding a simulator of a top-hat ion spectrometer with the output of the kinetic simulations, we show that measurements by such spectrometer planned on board the Turbulence Heating ObserveR (THOR mission), a candidate for the next M4 space mission of the European Space Agency, can provide detailed three-dimensional ion velocity distributions, highlighting important non-Maxwellian features. These results support the idea that future space missions will allow a deeper understanding of the physics of the interplanetary medium.
Burga, Laura N; Tung, Nadine M; Troyan, Susan L; Bostina, Mihnea; Konstantinopoulos, Panagiotis A; Fountzilas, Helena; Spentzos, Dimitrios; Miron, Alexander; Yassin, Yosuf A; Lee, Bernard T; Wulf, Gerburg M
2009-02-15
Female BRCA1 mutation carriers have a nearly 80% probability of developing breast cancer during their life-time. We hypothesized that the breast epithelium at risk in BRCA1 mutation carriers harbors mammary epithelial cells (MEC) with altered proliferation and differentiation properties. Using a three-dimensional culture technique to grow MECs ex vivo, we found that the ability to form colonies, an indication of clonality, was restricted to the aldehyde dehydrogenase 1-positive fraction in MECs but not in HCC1937 BRCA1-mutant cancer cells. Primary MECs from BRCA1 mutation carriers (n = 9) had a 28% greater ability for clonal growth compared with normal controls (n = 6; P = 0.006), and their colonies were significantly larger. Colonies in controls and BRCA1 mutation carriers stained positive for BRCA1 by immunohistochemistry, and 79% of the examined single colonies from BRCA1 carriers retained heterozygosity for BRCA1 (ROH). Colonies from BRCA1 mutation carriers frequently showed high epidermal growth factor receptor (EGFR) expression (71% EGFR positive versus 44% in controls) and were negative for estrogen receptor (ERalpha; 32% ER negative, 44% mixed, 24% ER positive versus 90% ER positive in controls). Expression of CK14 and p63 were not significantly different. Microarray studies revealed that colonies from BRCA1-mutant PMECs anticipate expression profiles found in BRCA1-related tumors, and that the EGFR pathway is up-regulated. We conclude that BRCA1 haploinsufficiency leads to an increased ability for clonal growth and proliferation in the PMECs of BRCA1 mutation carriers, possibly as a result of EGFR pathway activation. These altered growth and differentiation properties may render BRCA1-mutant PMECs vulnerable to transformation and predispose to the development of ER-negative, EGFR-positive breast cancers.
Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.
Jay R Thiagarajah
Full Text Available Hirschsprung disease-associated enterocolitis (HAEC leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a key role. Here we show that the colonic epithelium of both aganglionic and ganglionic segments are altered in patients and in mice with Hirschsprung disease (HSCR. Structurally, goblet cells were altered with increased goblet cell number and reduced intracellular mucins in the distal colon of biopsies from patients with HSCR. Endothelin receptor B (Ednrb mutant mice showed increased goblet cell number and size and increased cell proliferation compared to wild-type mice in aganglionic segments, and reduced goblet cell size and number in ganglionic segments. Functionally, compared to littermates, Ednrb-/- mice showed increased transepithelial resistance, reduced stool water content and similar chloride secretion in the distal colon. Transcript levels of goblet cell differentiation factors SPDEF and Math1 were increased in the distal colon of Ednrb-/- mice. Both distal colon from Ednrb mice and biopsies from HSCR patients showed reduced Muc4 expression as compared to controls, but similar expression of Muc2. Particle tracking studies showed that mucus from Ednrb-/- mice provided a more significant barrier to diffusion of 200 nm nanoparticles as compared to wild-type mice. These results suggest that aganglionosis is associated with increased goblet cell proliferation and differentiation and subsequent altered surface mucus properties, prior to the development of inflammation in the distal colon epithelium. Restoration of normal goblet cell function and mucus layer properties in the colonic epithelium may represent a therapeutic strategy for prevention of HAEC.
Tsili, Athina C., E-mail: a_tsili@yahoo.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Sylakos, Anastasios, E-mail: anasylakos@yahoo.gr [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Ntorkou, Alexandra, E-mail: alexdorkou@yahoo.com [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Stavrou, Sotirios, E-mail: s.sotiris@yahoo.gr [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Astrakas, Loukas G., E-mail: astrakas@uoi.gr [Department of Medical Physics, Medical School, University of Ioannina, 45110 Ioannina (Greece); Sofikitis, Nikolaos, E-mail: akrosnin@hotmail.com [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Argyropoulou, Maria I., E-mail: margyrop@cc.uoi.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece)
2015-07-15
Highlights: • Functional MRI in the characterization of testicular germ cell tumors was assessed. • ADC values proved useful in the characterization of testicular germ cell tumors. • Testicular germ cell tumors had similar enhancement patterns of dynamic MRI. - Abstract: Introduction: The aim of this study is to investigate the role of apparent diffusion coefficient (ADC) values and dynamic contrast enhancement (DCE) patterns in differentiating seminomas from nonseminomatous germ cell tumors (NSGCTs). Materials and methods: The MRI examinations of the scrotum of 26 men with histologically proven testicular GCTs were reviewed. DWI was performed in all patients, using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s/mm{sup 2}. Subtraction DCE-MRI was performed in 20 cases using a 3D fast-field echo sequence after gadolinium administration. Time-signal intensity curves were created and semi-quantitative parameters (peak enhancement, time to peak, wash-in and wash-out rate) were calculated. The Student's t-test was used to compare the mean values of ADC, peak enhancement, time to peak, wash-in and wash-out rate between seminomas and NSGCTs. ROC analysis was also performed. Results: Histopathology disclosed the presence of 15 seminomas and 11 NSGCTs. The mean ± s.d. of ADC values (× 10{sup −3} mm{sup 2}/s) of seminomas (0.59 ± 0.009) were significantly lower than those of NSGCTs (0.90 ± 0.33) (P = 0.01). The optimal ADC cut-off value was 0.68 × 10{sup −3} mm{sup 2}/s. No differences between the two groups were observed for peak enhancement (P = 0.18), time to peak (P = 0.63) wash-in rate (P = 0.32) and wash-out rate (P = 0.18). Conclusions: ADC values may be used to preoperatively differentiate seminomas from NSGCTs.
无
2002-01-01
The dynamic property of piezoelectric micro displacement actuator (PMDA) is analyzed, especially the mechanical characteristic, lag phase property and hysteresis phenomenon. The influence factors of static and dynamic mechanical characteristics and the lag phase property are analyzed systematically. Three main influence factors of lag phase property are discovered. With comparison to mechanical Coulomb friction, a generalized model of nonlinear hysteresis of PMDA is advanced, based on the essential analysis of nonlinear phenomenon. Finally the application of PMDA in error compensation control system of boring is introduced. A good compensation result is achieved.
V. Ovsianko
2012-01-01
Full Text Available The paper reveals a brand-new direction in simulation of frame and continual structures while calculating static and dynamic loads and stability. An electronic model has been synthesized for an investigated object and then it has been analyzed not with the help of specialized analog computing techniques but by means of high-performance software package for electronic circuit calculation using a personal computer.The given paper contains exact algebraic equations corresponding to differential equations for lateral bending calculation of frame structures without and with due account of viscoelastic material properties in compliance with the Kelvin model.The exact algebraic equation for a beam on elastic supports (or elastic Winkler foundation has been derived for quartic differential equation.The paper presents a number of exact algebraic equations which are equivalent to differential equations for transverse-longitudinal bending calculation of frame structures without and with due account of viscoelastic material properties when lateral and longitudinal loads are applied in the form of impulses with any periods of their duration and any interchangeability.
Berneman Zwi N
2009-12-01
Full Text Available Abstract Background Optimization of the current dendritic cell (DC culture protocol in order to promote the therapeutic efficacy of DC-based immunotherapy is warranted. Alternative differentiation of monocyte-derived DCs using granulocyte macrophage colony-stimulating factor (GM-CSF and interleukin (IL-15 has been propagated as an attractive strategy in that regard. The applicability of these so-called IL-15 DCs has not yet been firmly established. We therefore developed a novel pre-clinical approach for the generation of IL-15 DCs with potent immunostimulatory properties. Methods Human CD14+ monocytes were differentiated with GM-CSF and IL-15 into immature DCs. Monocyte-derived DCs, conventionally differentiated in the presence of GM-CSF and IL-4, served as control. Subsequent maturation of IL-15 DCs was induced using two clinical grade maturation protocols: (i a classic combination of pro-inflammatory cytokines (tumor necrosis factor-α, IL-1β, IL-6, prostaglandin E2 and (ii a Toll-like receptor (TLR7/8 agonist-based cocktail (R-848, interferon-γ, TNF-α and prostaglandin E2. In addition, both short-term (2-3 days and long-term (6-7 days DC culture protocols were compared. The different DC populations were characterized with respect to their phenotypic profile, migratory properties, cytokine production and T cell stimulation capacity. Results The use of a TLR7/8 agonist-based cocktail resulted in a more optimal maturation of IL-15 DCs, as reflected by the higher phenotypic expression of CD83 and costimulatory molecules (CD70, CD80, CD86. The functional superiority of TLR7/8-activated IL-15 DCs over conventionally matured IL-15 DCs was evidenced by their (i higher migratory potential, (ii advantageous cytokine secretion profile (interferon-γ, IL-12p70 and (iii superior capacity to stimulate autologous, antigen-specific T cell responses after passive peptide pulsing. Aside from a less pronounced production of bioactive IL-12p70, short
Hongyan Tu
2013-05-01
Full Text Available In order to study the moisture comfort property of fine denier polypropylene fiber fabric in different wind speed conditions, dynamic experiments were performed using Textile-Microclimate Measuring Instrument in climate chamber. The relative humidity variation curves of inner and outer surfaces of test fabrics were tested and the comprehensive index was introduced to evaluate fabric’s dynamic moisture comfort property. Results show that under four different environmental wind speed conditions, the dynamic moisture comfort property of fine denier polypropylene fiber fabric is much better than other fiber fabrics. In addition, grey mathematics theory was introduced to establish models to predict dynamic experiment’s results using static descriptive parameters. Four prediction models of dynamic comprehensive index were established and the predictive precision is much higher.
Tuning viscoelastic properties of supramolecular peptide gels via dynamic covalent crosslinking.
Khalily, Mohammad Aref; Goktas, Melis; Guler, Mustafa O
2015-02-21
A dynamic covalent crosslinking approach is used to crosslink supramolecular peptide gels. This novel approach facilitates tuning viscoelastic properties of the gel and enhances mechanical stability (storage modulus exceeding 10(5) Pa) of the peptide gels.
Mahairaki, Vasiliki; Ryu, Jiwon; Peters, Ann; Chang, Qing; Li, Tong; Park, Tea Soon; Burridge, Paul W; Talbot, Conover C; Asnaghi, Laura; Martin, Lee J; Zambidis, Elias T; Koliatsos, Vassilis E
2014-12-15
Although the majority of Alzheimer's disease (AD) cases are sporadic, about 5% of cases are inherited in an autosomal dominant pattern as familial AD (FAD) and manifest at an early age. Mutations in the presenilin 1 (PSEN1) gene account for the majority of early-onset FAD. Here, we describe the generation of virus-free human induced pluripotent stem cells (hiPSCs) derived from fibroblasts of patients harboring the FAD PSEN1 mutation A246E and fibroblasts from healthy age-matched controls using nonintegrating episomal vectors. We have differentiated these hiPSC lines to the neuronal lineage and demonstrated that hiPSC-derived neurons have mature phenotypic and physiological properties. Neurons from mutant hiPSC lines express PSEN1-A246E mutations themselves and show AD-like biochemical features, that is, amyloidogenic processing of amyloid precursor protein (APP) indicated by an increase in β-amyloid (Aβ)42/Aβ40 ratio. FAD hiPSCs harboring disease properties can be used as humanized models to test novel diagnostic methods and therapies and explore novel hypotheses for AD pathogenesis.
Chaudhury, Salma; Holland, Christopher; Porter, David; Tirlapur, Uday K; Vollrath, Fritz; Carr, Andrew J
2011-12-01
The cause of the high failure rates often observed following rotator cuff tendon repairs, particularly massive tears, is not fully understood. Collagen structural changes have been shown to alter tendon thermal and mechanical properties. This study aimed to form a quantitative rather than qualitative assessment, of whether differences in collagen structure and integrity existed between small biopsies of normal, small, and massive rotator cuff tears using differential scanning calorimetry. Thermal properties were measured for 28 human biopsies taken intra-operatively from normal, small, and massive rotator cuff tendon tears in this powered study. Denaturation temperatures are represented by T(onset) (°C) and T(peak) (°C). The T(onset) is proposed to represent water-amide hydrogen bond breakage and resulting protein backbone mobility. T(peak) reportedly corresponds to the temperature at which the majority of proteins fall out of solution. Denaturation enthalpy (ΔH) should correlate with the amount of triple helical structure that is denatured. Fluorescence and confocal microscopy allowed quantitative validation. Small and massive rotator cuff tears had significantly higher T(onset), T(peak), and ΔH compared to controls. Polarized light microscopy of torn tendons confirmed greater collagen structural disruption compared to controls. These novel findings suggest greater quantifiable collagen structural disruption in rotator cuff tears, compared to controls. This study offers insight into possible mechanisms for the reduced strength of torn tendons and may explain why repaired tendons fail to heal.
A differentiable reformulation for E-optimal design of experiments in nonlinear dynamic biosystems.
Telen, Dries; Van Riet, Nick; Logist, Flip; Van Impe, Jan
2015-06-01
Informative experiments are highly valuable for estimating parameters in nonlinear dynamic bioprocesses. Techniques for optimal experiment design ensure the systematic design of such informative experiments. The E-criterion which can be used as objective function in optimal experiment design requires the maximization of the smallest eigenvalue of the Fisher information matrix. However, one problem with the minimal eigenvalue function is that it can be nondifferentiable. In addition, no closed form expression exists for the computation of eigenvalues of a matrix larger than a 4 by 4 one. As eigenvalues are normally computed with iterative methods, state-of-the-art optimal control solvers are not able to exploit automatic differentiation to compute the derivatives with respect to the decision variables. In the current paper a reformulation strategy from the field of convex optimization is suggested to circumvent these difficulties. This reformulation requires the inclusion of a matrix inequality constraint involving positive semidefiniteness. In this paper, this positive semidefiniteness constraint is imposed via Sylverster's criterion. As a result the maximization of the minimum eigenvalue function can be formulated in standard optimal control solvers through the addition of nonlinear constraints. The presented methodology is successfully illustrated with a case study from the field of predictive microbiology.
Zhang, Xinyu; Cao, Jiguo; Carroll, Raymond J
2015-03-01
We consider model selection and estimation in a context where there are competing ordinary differential equation (ODE) models, and all the models are special cases of a "full" model. We propose a computationally inexpensive approach that employs statistical estimation of the full model, followed by a combination of a least squares approximation (LSA) and the adaptive Lasso. We show the resulting method, here called the LSA method, to be an (asymptotically) oracle model selection method. The finite sample performance of the proposed LSA method is investigated with Monte Carlo simulations, in which we examine the percentage of selecting true ODE models, the efficiency of the parameter estimation compared to simply using the full and true models, and coverage probabilities of the estimated confidence intervals for ODE parameters, all of which have satisfactory performances. Our method is also demonstrated by selecting the best predator-prey ODE to model a lynx and hare population dynamical system among some well-known and biologically interpretable ODE models.
Glycolipid dynamics in generation and differentiation of induced pluripotent stem cells.
Ojima, Takuma; Shibata, Eri; Saito, Shiho; Toyoda, Masashi; Nakajima, Hideki; Yamazaki-Inoue, Mayu; Miyagawa, Yoshitaka; Kiyokawa, Nobutaka; Fujimoto, Jun-ichiro; Sato, Toshinori; Umezawa, Akihiro
2015-10-19
Glycosphingolipids (GSLs) are glycoconjugates that function as mediators of cell adhesion and modulators of signal transduction. Some well-defined markers of undifferentiated human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are glycoconjugates, such as SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81. However, Comprehensive GSL profiles of hiPSCs have not yet been elucidated. The global images of GSLs from the parental cells, hiPSCs, and differentiated cells revealed that there are parental cell-independent specific glycolipids, including Globo H (fucosyl-Gb5Cer) and H type1 antigen (fucosyl-Lc4Cer) that are novel markers for undifferentiated hiPSCs. Interestingly, undifferentiated hiPSCs expressed H type 1 antigen, specific for blood type O, regardless of the cells' genotypes. Thus, in this study, we defined the dynamics of GSL remodeling during reprogramming from parental cell sets to iPSC sets and thence to iPSC-neural cells.
2007-03-01
Document, 2006. 26. D. Mehrholz, W. Flury R. Jehn H. Klinkrad M. Landgraf, L. Leushacke. “De- tecting, Tracking and Imaging Space Debris ”. Eurpean Space ...SPACECRAFT PROXIMITY OPERATIONS USED TO ESTIMATE THE DYNAMICAL & PHYSICAL PROPERTIES OF A RESIDENT SPACE OBJECT THESIS Abraham Franz Brunner, First...OPERATIONS USED TO ESTIMATE THE DYNAMICAL & PHYSICAL PROPERTIES OF A RESIDENT SPACE OBJECT THESIS Presented to the Faculty Department of Aeronautics and
2016-01-01
The dynamic wetting properties of atomic force microscopy (AFM) tips are of much concern in many AFM-related measurement, fabrication, and manipulation applications. In this study, the wetting properties of silicon and silicon nitride AFM tips are investigated through dynamic contact angle measurement using a nano-Wilhelmy balance based method. This is done by capillary force measurement during extension and retraction motion of AFM tips relative to interfacial nanobubbles. The working princi...
Static and dynamic properties of poly(3-hexylthiophene) films at liquid/vacuum interfaces.
Yimer, Yeneneh Y; Tsige, Mesfin
2012-11-28
All-atom molecular dynamics simulations are used to study static and dynamic properties of poly(3-hexylthiophene) (P3HT) films at liquid/vacuum interfaces with regards to their dependence on both temperature and molecular weight. The static properties of the films are characterized by calculating specific volume, interfacial width, orientational ordering of the hexyl groups, and surface tension. The specific volume found to be a monotonically decreasing function of the molecular weight while its dependence on temperature follows the Simha-Somcynsky's equation of state. The orientational ordering calculations show the hexyl groups protruding from the vacuum side of the interface, where the degree of order at the interface is found to be strongly dependent on both temperature and molecular weight. The surface tension values show a linear dependence on temperature and the molecular weight dependence is equally described by both M(-2∕3) and M(-1) power law models. The dynamic properties are quantified by calculating diffusion coefficients for the chain centers-of-mass and thiophene ring segments as well as first-order and second-order end-to-end vector autocorrelations and chain backbone torsion autocorrelation. All calculated dynamic properties show strong dependence on both temperature and molecular weight. All the autocorrelations are well described by Kohlrausch-Williams-Watts equation. Our detailed analysis of the static and dynamic properties of P3HT films show that the calculated static and dynamic properties data can be fit with well-known polymer models.
Effect of dynamically charged helium on tensile properties of V-4Cr-4Ti
Chung, H.M.; Loomis, B.A.; Nowicki, L.; Smith, D.L. [Argonne National Lab., IL (United States)
1995-04-01
The objective of this work is to determine the effect of displacement damage and dynamically charged helium on tensile properties of V-4Cr-4Ti alloy irradiated to 18-31 dpa at 425-600{degree}C in the Dynamic Helium Charging Experiment (DHCE).
Droplets in microchannels: dynamical properties of the lubrication film
Huerre, Axel; Theodoly, Olivier; Leshansky, Alexander; Valignat, Marie-Pierre; Cantat, Isabelle; Jullien, Marie-Caroline
2015-11-01
The motion of droplets or bubbles in confined geometries has been extensively studied; showing an intrinsic relationship between the lubrication film thickness and the droplet velocity. When capillary forces dominate, the lubrication film thickness evolves non linearly with the capillary number due to viscous dissipation both in the droplet and between meniscus and wall. However, this film may become thin enough (tens of nanometers) that intermolecular forces come into play and affect classical scalings. Our experiments yield highly resolved topographies of the shape of the interface and allow us to bring new insights into droplet dynamics in microfluidics. We find and characterize two distinct dynamical regimes, dominated respectively by capillary and intermolecular forces. In the first regime, we also identified a model with interfacial boundary condition considering only viscous stress continuity that agrees well with film thickness dynamics and interface velocity measurement.
Dupuy Fabrice
2009-10-01
Full Text Available Abstract Background Several global transcriptomic and proteomic approaches have been applied in order to obtain new molecular insights on skeletal myogenesis, but none has generated any specific data on glycogenome expression, and thus on the role of glycan structures in this process, despite the involvement of glycoconjugates in various biological events including differentiation and development. In the present study, a quantitative real-time RT-PCR technology was used to profile the dynamic expression of 375 glycogenes during the differentiation of C2C12 myoblasts into myotubes. Results Of the 276 genes expressed, 95 exhibited altered mRNA expression when C2C12 cells differentiated and 37 displayed more than 4-fold up- or down-regulations. Principal Component Analysis and Hierarchical Component Analysis of the expression dynamics identified three groups of coordinately and sequentially regulated genes. The first group included 12 down-regulated genes, the second group four genes with an expression peak at 24 h of differentiation, and the last 21 up-regulated genes. These genes mainly encode cell adhesion molecules and key enzymes involved in the biosynthesis of glycosaminoglycans and glycolipids (neolactoseries, lactoseries and ganglioseries, providing a clearer indication of how the plasma membrane and extracellular matrix may be modified prior to cell fusion. In particular, an increase in the quantity of ganglioside GM3 at the cell surface of myoblasts is suggestive of its potential role during the initial steps of myogenic differentiation. Conclusion For the first time, these results provide a broad description of the expression dynamics of glycogenes during C2C12 differentiation. Among the 37 highly deregulated glycogenes, 29 had never been associated with myogenesis. Their biological functions suggest new roles for glycans in skeletal myogenesis.
Dynamic Properties of OffshoreWind Turbine Foundations
Damgaard, Mads
and soil damping applied as modal damping. The methods, however, do not account for the dynamic stiffness due to inertia forces, and a well-defined representation of the dissipation effects in the soil is neglected. This in turn forms the basis of the current PhD thesis that examines the soil...... of the dynamic wind turbine response. To overcome this, sequential or fully coupled aero-hydro-elastic simulations are often conducted where the soil?structure interaction is incorporated via the principle of an equivalent fixity depth or by a so-called Winkler approach with static springs along the foundation...
Dynamical Properties of Potassium Ion Channels with a Hierarchical Model
ZHAN Yong; AN Hai-Long; YU Hui; ZHANG Su-Hua; HAN Ying-Rong
2006-01-01
@@ It is well known that potassium ion channels have higher permeability than K ions, and the permeable rate of a single K ion channel is about 108 ions per second. We develop a hierarchical model of potassium ion channel permeation involving ab initio quantum calculations and Brownian dynamics simulations, which can consistently explain a range of channel dynamics. The results show that the average velocity of K ions, the mean permeable time of K ions and the permeable rate of single channel are about 0.92nm/ns, 4.35ns and 2.30×108 ions/s,respectively.
Full Text Available 18251777 Macrophage differentiation and function in health and disease. Naito M. Pa...thol Int. 2008 Mar;58(3):143-55. (.png) (.svg) (.html) (.csml) Show Macrophage differentiation and function in health... and disease. PubmedID 18251777 Title Macrophage differentiation and function in health and disease
Rosa, Stefanie; Ntoukakis, Vardis; Ohmido, Nobuko; Pendle, Ali; Abranches, Rita; Shaw, Peter
2014-12-01
The mechanism whereby the same genome can give rise to different cell types with different gene expression profiles is a fundamental problem in biology. Chromatin organization and dynamics have been shown to vary with altered gene expression in different cultured animal cell types, but there is little evidence yet from whole organisms linking chromatin dynamics with development. Here, we used both fluorescence recovery after photobleaching and two-photon photoactivation to show that in stem cells from Arabidopsis thaliana roots the mobility of the core histone H2B, as judged by exchange dynamics, is lower than in the surrounding cells of the meristem. However, as cells progress from meristematic to fully differentiated, core histones again become less mobile and more strongly bound to chromatin. We show that these transitions are largely mediated by changes in histone acetylation. We further show that altering histone acetylation levels, either in a mutant or by drug treatment, alters both the histone mobility and markers of development and differentiation. We propose that plant stem cells have relatively inactive chromatin, but they keep the potential to divide and differentiate into more dynamic states, and that these states are at least in part determined by histone acetylation levels. © 2014 American Society of Plant Biologists. All rights reserved.
Dietrich, Olaf; Levin, Johannes; Ahmadi, Seyed-Ahmad; Plate, Annika; Reiser, Maximilian F; Bötzel, Kai; Giese, Armin; Ertl-Wagner, Birgit
2017-04-01
The aim of this study is to evaluate the MR imaging behavior of ferrous (Fe(2+)) and ferric (Fe(3+)) iron ions in order to develop a noninvasive technique to quantitatively differentiate between both forms of iron. MRI was performed at 3 T in a phantom consisting of 21 samples with different concentrations of ferrous and ferric chloride solutions (between 0 and 10 mmol/L). A multi-echo spoiled gradient-echo pulse sequence with eight echoes was used for both T 2* and quantitative susceptibility measurements. The transverse relaxation rate, R 2* = 1/T 2*, was determined by nonlinear exponential fitting based on the mean signals in each sample. The susceptibilities, χ, of the samples were calculated after phase unwrapping and background field removal by fitting the spatial convolution of a unit dipole response to the measured internal field map. Relaxation rate changes, ΔR 2*(c Fe), and susceptibility changes, Δχ(c Fe), their linear slopes, as well as the ratios ΔR 2*(c Fe) / Δχ(c Fe) were determined for all concentrations. The linear slopes of the relaxation rate were (12.5 ± 0.4) s(-1)/(mmol/L) for Fe(3+) and (0.77 ± 0.09) s(-1)/(mmol/L) for Fe(2+) (significantly different, z test P relaxation behaviors in MRI but similar susceptibility patterns. These properties can be used to differentiate ferrous and ferric samples.
Static and dynamic through thickness lamina properties of thick laminates
Lahuerta, F.; Nijssen, R.P.L.; Van der Meer, F.P.; Sluys, L.J.
2015-01-01
Thick laminates are increasingly present in large composites structures such as wind turbine blades. Different factors are suspected to be involved in the decreased static and dynamic performance of thick laminates. These include the effect of self-heating, the scaling effect, and the manufacturing
Structure and Dynamic Properties of Membrane Proteins using NMR
Rösner, Heike; Kragelund, Birthe
2012-01-01
, a large variety of developments of well-established techniques are available providing insight into membrane protein flexibility, dynamics, and interactions. Inspired by the speed of development in the application of new strategies, by invention of methods to measure solvent accessibility and describe low...
Dynamic test devices for analyzing the tensile properties of concrete
Forquin, P.; Riedel, W.; Weerheijm, J.
2013-01-01
Owing to their low tensile failure strain, concrete is a difficult material to test under dynamic tensile loading. Indeed, conventional testing apparatuses such as high-speed hydraulic presses or Split Hopkinson Bar facilities rely on a mechanical balance of the specimen implying a short round-trip
Universal properties of dynamically complex systems - The organization of chaos
Procaccia, Itamar
1988-06-01
The complex dynamic behavior of natural systems far from equilibrium is discussed. Progress that has been made in understanding universal aspects of the paths to such behavior, of the trajectories at the borderline of chaos, and of the nature of the complexity in the chaotic regime, is reviewed. The emerging grammar of chaos is examined.
Dynamic Resource Management under Weak Property Rights : A Tale of Thieves and Trespassers
Rodriguez Acosta, Mauricio; Smulders, Sjak
2016-01-01
Using a dynamic framework with strategic interactions, we study the management of a non-renewable natural resource when property rights are generally weak. Under generally weak property rights both the resource stock and the revenues from exploiting it are imperfectly protected, due to trespassing a
Spectral properties of the one-dimensional Hubbard model: cluster dynamical mean-field approaches
Go, Ara; Jeon, Gun Sang
2011-03-01
We investigate static and dynamic properties of the one-dimensional Hubbard model using cluster extensions of the dynamical mean-field theory. It is shown that the two different extensions, the cellular dynamical mean-field theory and the dynamic cluster approximation, yield the ground-state properties which are qualitatively in good agreement with each other. We compare the results with the Bethe ansatz results to check the accuracy of the calculation with finite sizes of clusters. We also analyze the spectral properties of the model with the focus on the spin-charge separation and discuss the dependency on the cluster size in the two approaches. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(2010-0010937).
Athanasios A. Pantelous
2010-01-01
Full Text Available In some interesting applications in control and system theory, linear descriptor (singular matrix differential equations of higher order with time-invariant coefficients and (non- consistent initial conditions have been used. In this paper, we provide a study for the solution properties of a more general class of the Apostol-Kolodner-type equations with consistent and nonconsistent initial conditions.
D'Amelia, Ronald; Franks, Thomas; Nirode, William F.
2007-01-01
In first-year general chemistry undergraduate courses, thermodynamics and thermal properties such as melting points and changes in enthalpy ([Delta]H) and entropy ([Delta]S) of phase changes are frequently discussed. Typically, classical calorimetric methods of analysis are used to determine [Delta]H of reactions. Differential scanning calorimetry…
D'Amelia, Ronald; Franks, Thomas; Nirode, William F.
2007-01-01
In first-year general chemistry undergraduate courses, thermodynamics and thermal properties such as melting points and changes in enthalpy ([Delta]H) and entropy ([Delta]S) of phase changes are frequently discussed. Typically, classical calorimetric methods of analysis are used to determine [Delta]H of reactions. Differential scanning calorimetry…
The dynamic properties of the two-level entangled atom in an optical field
无
2003-01-01
The interaction of an optical field and one of the entangled atoms is analyzed in detail in this paper. Furthermore, the dynamic properties of the two-level entangled atom are manifested. The properties of the action are dependent on the initial state of the atom. After detecting the atom out of the field, we can obtain the state of the other atom moving in the field. It is shown that the state of the atom out of the field influences the dynamic properties of the atom in the field.
Thomas, Alissa A; Arevalo-Perez, Julio; Kaley, Thomas; Lyo, John; Peck, Kyung K; Shi, Weiji; Zhang, Zhigang; Young, Robert J
2015-10-01
Pseudoprogression may present as transient new or increasing enhancing lesions that mimic recurrent tumors in treated glioblastoma. The purpose of this study was to examine the utility of dynamic contrast enhanced T1 magnetic resonance imaging (DCE MRI) in differentiating between pseudoprogression and tumor progression and devise a cut-off value sensitive for pseudoprogression. We retrospectively examined 37 patients with glioblastoma treated with radiation and temozolomide after surgical resection that then developed new or increasing enhancing lesion(s) indeterminate for pseudoprogression versus progression. Volumetric plasma volume (Vp) and time-dependent leakage constant (Ktrans) maps were measured for the enhancing lesion and the mean and ninetieth percentile histogram values recorded. Lesion outcome was determined by clinical follow up with pseudoprogression defined as stable disease not requiring new treatment. Statistical analysis was performed with Wilcoxon rank-sum tests. Patients with pseudoprogression (n = 13) had Vp (mean) = 2.4 and Vp (90 %tile) = 3.2; and Ktrans (mean) = 3.5 and Ktrans (90 %tile) = 4.2. Patients with tumor progression (n = 24) had Vp (mean) = 5.3 and Vp (90 %tile) = 6.6; and Ktrans (mean) = 7.4 and Ktrans (90 %tile) = 9.1. Compared with tumor progression, pseudoprogression demonstrated lower Vp perfusion values (p = 0.0002) with a Vp (mean) cutoff mean) of >3.6 had a 69% sensitivity and 79% specificity for disease progression. DCE MRI shows lower plasma volume and time dependent leakage constant values in pseudoprogression than in tumor progression. A cut-off value with high sensitivity for pseudoprogression can be applied to aid in interpretation of DCE MRI.
Chen, Chih-Ho; Huang, Yi-Chuan; Kuo, Kuang-Che; Li, Chung-Chen
2017-06-30
Dengue fever is not easily to be diagnosed before presentation of the classic symptoms. The study aimed to investigate the clinical features and dynamic laboratory tests in pediatric patients to facilitate dengue diagnosis. This retrospective study examined the medical records of all pediatric patients who were clinically suspected to have dengue from June to December 2014. Laboratory-positive dengue cases were confirmed by detecting non-structural protein NS1, reverse transcription-polymerase chain reaction of dengue virus, and dengue-specific IgM seroconversion. Of the 317 pediatric cases clinically suspected of dengue, 205 were laboratory-positive and 112 were laboratory-negative. In laboratory-positive cases, the most common clinical manifestation was skin rash in 156 (76.1%). Leukopenia occurred on days 1-5; thrombocytopenia, on days 2-7; prolonged activated partial thromboplastin time (aPTT), on days 1-4; and elevated transaminase levels, on days 3-11; and low CRP, on days 0-14. The specificity and positive predictive value (PPV) of combining of rash, itching and petechiae increased up to 100%. The PPV of combining of leukopenia, thrombocytopenia, and elevated transaminase levels reached 100% on day 2 as well as days 6-8. Leukopenia, thrombocytopenia, elevated aPTT, elevated transaminase levels, and low CRP could be used to differentiate dengue fever from other febrile illnesses. During dengue epidemics, combinations of the symptoms and laboratory findings are helpful to physicians for accurate diagnosis of dengue fever. Copyright © 2017. Published by Elsevier B.V.
Study of differential properties of fibrochondrocytes and hyaline chondrocytes in growing rabbits.
Huang, L; Li, M; Li, H; Yang, C; Cai, X
2015-02-01
We aimed to build a culture model of chondrocytes in vitro, and to study the differential properties between fibrochondrocytes and hyaline chondrocytes. Histological sections were stained with haematoxylin and eosin so that we could analyse the histological structure of the fibrocartilage and hyaline cartilage. Condylar fibrochondrocytes and femoral hyaline chondrocytes were cultured from four, 4-week-old, New Zealand white rabbits. The production of COL2A1, COL1OA1, SOX9 and aggrecan was detected by real time-q polymerase chain reaction (RT-qPCR) and immunoblotting and the differences between them were compared statistically. Histological structures obviously differed between fibrocartilage and hyaline cartilage. COL2A1 and SOX9 were highly expressed within cell passage 2 (P2) of both fibrochondrocytes and hyaline chondrocytes, and reduced significantly after cell passage 4 (P4). The mRNA expressions of COL2A1 (p=0.05), COL10A1 (p=0.04), SOX9 (p=0.03), and aggrecan (p=0.04) were significantly higher in hyaline chondrocytes than in fibrochondrocytes, whereas the expression of COL1A1 (p=0.02) was the opposite. Immunoblotting showed similar results. We have built a simple and effective culture model of chondrocytes in vitro, and the P2 of chondrocytes is recommended for further studies. Condylar fibrocartilage and femoral hyaline cartilage have unique biological properties, and the regulatory mechanisms of endochondral ossification for the condyle should be studied independently in the future. Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Bandwidth Resource Dynamic Allocation in Differentiated Services Model%Diffserv中带宽代理BB的实现
邱瑜; 朱淼良
2003-01-01
To employ Differentiated Services, efficient and flexible resource allocation mechanism is needed. Static bandwidth resource allocation Is not suitable for the situations in which traffic varies greatly with times. If customers bought bandwidth according to their highest traffic demands, some resource will be wasted when traffic load is light. On the other hand, the static allocated bandwidth may not satisfy the growing traffic demands. So it is necessary to allocate bandwidth resource in dynamic way. We bring up a prototype of BB, discussing the necessary components to realize the dynamic bandwidth resource allocation and further more, our BB can provides advanced reservation for bandwidth resource. Simulation tests show our design is feasible.
Dynamical systems approach and generic properties of f (T ) cosmology
Hohmann, Manuel; Järv, Laur; Ualikhanova, Ulbossyn
2017-08-01
We present a systematic analysis of the dynamics of flat Friedmann-Lemaître-Robertson-Walker cosmological models with radiation and dust matter in generalized teleparallel f (T ) gravity. We show that the cosmological dynamics of this model are fully described by a function W (H ) of the Hubble parameter, which is constructed from the function f (T ) . After reducing the phase space to two dimensions, we derive the conditions on W (H ) for the occurrence of de Sitter fixed points, accelerated expansion, crossing the phantom divide, and finite time singularities. Depending on the model parameters, it is possible to have a bounce (from contraction to expansion) or a turnaround (from expansion to contraction), but cyclic or oscillating scenarios are prohibited. As an illustration of the formalism we consider power law f (T )=T +α (-T )n models, and show that these allow only one period of acceleration and no phantom divide crossing.
Dynamical Transport Property through an Interacting Quantum Wire
CHENG Fang; ZHOU Guang-Hui
2005-01-01
@@ Using the equation of motion, we investigate theoretically the dynamical ac conductance of a clean Luttingerliquid quantum wire adiabatically coupled to Fermi liquid electron reservoirs in the presence of short-ranged electron-electron interactions. For a perfect single mode quantum wire, in the limit of zero-ranged interaction we conclude that the static dc conductance of ω→ 0 is e2/h, which is independent of the electron interactions. While in the dynamical case of ω≠ 0, the ac conductance oscillates with the amplitude e2/h and the period which depends on the interaction strength and the driving frequency as well as the position in the wire.
Overall Dynamic Properties of 3-D periodic elastic composites
Srivastava, Ankit
2011-01-01
A method for the homogenization of 3-D periodic elastic composites is presented. It allows for the evaluation of the averaged overall frequency dependent dynamic material constitutive tensors relating the averaged dynamic ?eld variable tensors of velocity, strain, stress, and linear momentum. The formulation is based on micromechanical modeling of a representative unit cell of a composite proposed by Nemat-Nasser & Hori (1993), Nemat-Nasser et. al. (1982) and Mura (1987) and is the 3-D generalization of the 1-D elastodynamic homogenization scheme presented by Nemat-Nasser & Srivastava (2011). We show that for 3-D periodic composites the overall compliance (stiffness) tensor is hermitian, irrespective of whether the corresponding unit cell is geometrically or materially symmetric.Overall mass density is shown to be a tensor and, like the overall compliance tensor, always hermitian. The average strain and linear momentum tensors are, however, coupled and the coupling tensors are shown to be each others'...
Molecular dynamics simulation of nanocrystalline nickel: structure and mechanical properties
Swygenhoven, H. van [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Caro, A. [Comision Nacional de Energia Atomica, San Carlos de Bariloche (Argentina). Centro Atomico Bariloche
1997-09-01
Molecular dynamics computer simulations of low temperature elastic and plastic deformation of Ni nanophase samples (3-7 nm) are performed. The samples are polycrystals nucleated from different seeds, with random locations and orientations. Bulk and Young`s modulus, onset of plastic deformation and mechanism responsible for the plastic behaviour are studied and compared with the behaviour of coarse grained samples. (author) 1 fig., 3 refs.
Some Dynamical Properties in Set-valued Discrete Systems
马先峰; 廖公夫; 李勇
2005-01-01
A discrete dynamical system can be expressed as xn+1 =f(xn), n=0,1, 2,... where X isa metric space and f : X→X is a continuous map. The study of it tells us how the points in the base space X moved. Nevertheless, this is not enough for the researches of biological species, demography, numerical simulation and attractors (see [1], [2]).
Yenjerla, Mythili; Lopus, Manu; Wilson, Leslie
2010-01-01
Microtubules are major constituents of the cytoskeleton which display dynamic properties. They exhibit dynamic instability which is defined as the stochastic switching between growing and shortening at microtubule ends. Dynamic instability plays an important role in diverse cellular functions including cell migration and mitosis. Many successful antimitotic drugs and microtubule-associated proteins (MAPs) are known to modulate microtubule dynamics, and it is important to analyze the in vitro dynamic instability of microtubules to study the mechanism of action of microtubule-targeted therapeutics and MAPs. In this chapter, we describe a method to analyze the in vitro dynamic instability of microtubules at steady state using video-enhanced differential contrast (VE-DIC) microscopy in detail. In this method, microtubules are assembled to steady state at 30 degrees C with MAP-free tubulin in a slide chamber in the presence of GTP, using sea urchin axonemes as nucleating seeds. Images of microtubules are enhanced and recorded in real time by a video camera and an image processor connected to a DIC microscope which is maintained at 30 degrees C. We use two software programs to track and analyze the growing and shortening of plus or minus ends of microtubules in the real-time images recorded using VE-DIC. In this chapter, we describe the instructions to use the tracking software Real Time Measurement II (RTM II) program. The instructions to use the analysis software Microtubule Life History Analysis Procedures (MT-LHAP) in Igor Pro software have been described in detail in an appendix (Oroudjev, 2010) following this chapter.
Static and dynamic properties of large polymer melts in equilibrium
Hsu, Hsiao-Ping; Kremer, Kurt
2016-04-01
We present a detailed study of the static and dynamic behaviors of long semiflexible polymer chains in a melt. Starting from previously obtained fully equilibrated high molecular weight polymer melts [G. Zhang et al., ACS Macro Lett. 3, 198 (2014)], we investigate their static and dynamic scaling behaviors as predicted by theory. We find that for semiflexible chains in a melt, results of the mean square internal distance, the probability distributions of the end-to-end distance, and the chain structure factor are well described by theoretical predictions for ideal chains. We examine the motion of monomers and chains by molecular dynamics simulations using the ESPResSo++ package. The scaling predictions of the mean squared displacement of inner monomers, center of mass, and relations between them based on the Rouse and the reptation theory are verified, and related characteristic relaxation times are determined. Finally, we give evidence that the entanglement length Ne,PPA as determined by a primitive path analysis (PPA) predicts a plateau modulus, GN 0 = /4 5 ( ρ k B T / N e ) , consistent with stresses obtained from the Green-Kubo relation. These comprehensively characterized equilibrium structures, which offer a good compromise between flexibility, small Ne, computational efficiency, and small deviations from ideality, provide ideal starting states for future non-equilibrium studies.
Acoustic properties in glycerol glass-former: Molecular dynamics simulation
Busselez, Remi; Pezeril, Thomas; Institut des Materiaux et Molecules du Mans Team
2013-03-01
Study of high-frequency collective dynamics around TeraHertz region in glass former has been a subject of intense investigations and debates over the past decade. In particular, the presence of the Boson peak characteristic of glassy material and its relation to other glass anomalies. Recently, experiments and simulations have underlined possible relation between Boson peak and transverse acoustic modes in glassy materials. In particular, simulations of simple Lennard Jones glass former have shown a relation between Ioffe-Regel criterion in transverse modes and Boson peak. We present here molecular dynamics simulation on high frequency dynamics of glycerol. In order to study mesoscopic order (0.5-5nm-1), we made use of large simulation box containing 80000 atoms. Analysis of collective longitudinal and transverse acoustic modes shows striking similarities in comparison with simulation of Lennard-Jones particles. In particular, it seems that a connection may exist between Ioffe-Regel criterion for transverse modes and Bose Peak frequency. However,in our case we show that this connection may be related with structural correlation arising from molecular clusters.
无
2006-01-01
In order to evaluate the value of magnetic resonance cholangiography (MRC) and dynamic examination of duodenal fluid in the differential diagnosis between extrahepatic biliary atresia (EHBA) and infantile hepatitis syndrome (IHS), 52 pa tients with infantile cholestatic jaundice were examined by MRC and duodenal fluid examination. Original interpretations were compared with clinical outcome. Calculated sensitivity of duodenal fluid examination in diagnosis of EHBA was 100%, and specificity was 91.1%. Sensitivity of MRC in the diagnosis of EHBA was 94.4 % and specificity 88.24 %. The sensitivity of MRC and examination of duodenal fluid combined in diagnosis of EHBA was 94.4 % and specificity 97.06 %. We are led to conclude that MRC and dynamic examination of duodenal fluid are useful in the differential diagnosis between IHS and EHBA and the combined use of the two techniques yield better resutls.
The Derivation, Properties and Value of Kepler's Combined Differential Photometric Precision
Christiansen, Jessie L; Barclay, Thomas S; Burke, Christopher J; Caldwell, Douglas A; Clarke, Bruce D; Li, Jie; Seader, Shawn; Smith, Jeffrey C; Stumpe, Martin C; Tenenbaum, Peter; Thompson, Susan E; Twicken, Joseph D; Van Cleve, Jeffrey
2012-01-01
The Kepler Mission is searching for Earth-size planets orbiting solar-like stars by simultaneously observing >160,000 stars to detect sequences of transit events in the photometric light curves. The Combined Differential Photometric Precision (CDPP) is the metric that defines the ease with which these weak terrestrial transit signatures can be detected. An understanding of CDPP is invaluable for evaluating the completeness of the Kepler survey and inferring the underlying planet population. This paper describes how the Kepler CDPP is calculated, and introduces tables of rms CDPP on a per-target basis for 3-, 6-, and 12-hour transit durations, which are now available for all Kepler observations. Quarter 3 is the first typical set of observations at the nominal length and completeness for a quarter, from 2009 September 18 to 2009 December 16, and we examine the properties of the rms CDPP distribution for this data set. Finally, we describe how to employ CDPP to calculate target completeness, an important use ca...
Kimura, Noriyuki; Nishimura, Nana; Iwama, Nagako; Aihara, Yoshito; Ogawa, Yasuki; Miyaguchi, Yuji
2017-10-01
The thermal property of bovine intramuscular adipose tissue (IAT) was evaluated using differential scanning calorimetry (DSC) and compared with the melting point temperature (MP) of the fat extract of IAT, which was measured using the slip point method. The beef samples were classified according to the beef marbling score (BMS). Beef with a high BMS contained less protein than that with middle or low BMS. Beef with a high BMS contained significantly more fat than that with a low BMS (P < 0.05). The endothermic point temperature (EP) of IAT, measured by DSC, was significantly higher than the MP of IAT fat (P < 0.05). The EP showed no significant difference among the three marbling grade groups. Although the MP was correlated with the monounsaturated fatty acids (MUFA) content of IAT (R(2) = 0.505), there was no correlation between the EP and the MUFA (R(2) = 0.040). However, the EP of IAT treated with collagenase was relatively highly correlated with the MP (R(2) = 0.655). Thus, these results suggested that DSC analysis would give us the practical thermal information regarding the melt-in the-mouth of beef such as the gelatinization of collagen, along with the melting of fat in IAT. © 2017 The Authors. Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science.
Kwiatkowski JL
2011-09-01
Full Text Available Janet L Kwiatkowski The Children's Hospital of Philadelphia, Division of Hematology and University of Pennsylvania School of Medicine, Philadelphia, PA, USA Abstract: Regular red cell transfusion therapy ameliorates disease-related morbidity and can be lifesaving in patients with various hematological disorders. Transfusion therapy, however, causes progressive iron loading, which, if untreated, results in endocrinopathies, cardiac arrhythmias and congestive heart failure, hepatic fibrosis, and premature death. Iron chelation therapy is used to prevent iron loading, remove excess accumulated iron, detoxify iron, and reverse some of the iron-related complications. Three chelators have undergone extensive testing to date: deferoxamine, deferasirox, and deferiprone (although the latter drug is not currently licensed for use in North America where it is available only through compassionate use programs and research protocols. These chelators differ in their modes of administration, pharmacokinetics, efficacy with regard to organ-specific iron removal, and adverse-effect profiles. These differential properties influence acceptability, tolerability and adherence to therapy, and, ultimately, the effectiveness of treatment. Chelation therapy, therefore, must be individualized, taking into account patient preferences, toxicities, ongoing transfusional iron intake, and the degree of cardiac and hepatic iron loading. Keywords: transfusion, iron, chelation, magnetic resonance imaging
A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds
Giuliano Malloci
2015-08-01
Full Text Available We present an on-line database of all-atom force-field parameters and molecular properties of compounds with antimicrobial activity (mostly antibiotics and some beta-lactamase inhibitors. For each compound, we provide the General Amber Force Field parameters for the major species at physiological pH, together with an analysis of properties of interest as extracted from µs-long molecular dynamics simulations in explicit water solution. The properties include number and population of structural clusters, molecular flexibility, hydrophobic and hydrophilic molecular surfaces, the statistics of intraand inter-molecular H-bonds, as well as structural and dynamical properties of solvent molecules within first and second solvation shells. In addition, the database contains several key molecular parameters, such as energy of the frontier molecular orbitals, vibrational properties, rotational constants, atomic partial charges and electric dipole moment, computed by Density Functional Theory. The present database (to our knowledge the first extensive one including dynamical properties is part of a wider project aiming to build-up a database containing structural, physico-chemical and dynamical properties of medicinal compounds using different force-field parameters with increasing level of complexity and reliability. The database is freely accessible at http://www.dsf.unica.it/translocation/db/.
Wu, Fuke; Yin, George; Mei, Hongwei
2017-02-01
This work is devoted to stochastic functional differential equations (SFDEs) with infinite delay. First, existence and uniqueness of the solutions of such equations are examined. Because the solutions of the delay equations are not Markov, a viable alternative for studying further asymptotic properties is to use solution maps or segment processes. By examining solution maps, this work investigates the Markov properties as well as the strong Markov properties. Also obtained are adaptivity and continuity, mean-square boundedness, and convergence of solution maps from different initial data. This paper then examines the ergodicity of underlying processes and establishes existence of the invariant measure for SFDEs with infinite delay under suitable conditions.
Balibrea-Iniesta, Francisco; Lopesino, Carlos; Wiggins, Stephen; Mancho, Ana M.
2016-12-01
In this paper, we introduce a new technique for depicting the phase portrait of stochastic differential equations. Following previous work for deterministic systems, we represent the phase space by means of a generalization of the method of Lagrangian descriptors to stochastic differential equations. Analogously to the deterministic differential equations setting, the Lagrangian descriptors graphically provide the distinguished trajectories and hyperbolic structures arising within the stochastic dynamics, such as random fixed points and their stable and unstable manifolds. We analyze the sense in which structures form barriers to transport in stochastic systems. We apply the method to several benchmark examples where the deterministic phase space structures are well-understood. In particular, we apply our method to the noisy saddle, the stochastically forced Duffing equation, and the stochastic double gyre model that is a benchmark for analyzing fluid transport.
Zhang, Yue; Zheng, Yan; Liu, Xi; Zhang, Qingling; Li, Aihua
2016-11-01
This study considers a class of differential algebraic stage-structured bio-economic models with stochastic fluctuations. The stochastic bio-economic model is simplified to an Itô equation using the stochastic averaging method. The stochastic stability, Hopf bifurcation, and P-bifurcation are discussed based on the singular boundary theory of the diffusion process for the system and the invariant measure theory of dynamic systems. Numerical simulations are presented to illustrate our main results.
Huynh, H. T.; Wang, Z. J.; Vincent, P. E.
2013-01-01
Popular high-order schemes with compact stencils for Computational Fluid Dynamics (CFD) include Discontinuous Galerkin (DG), Spectral Difference (SD), and Spectral Volume (SV) methods. The recently proposed Flux Reconstruction (FR) approach or Correction Procedure using Reconstruction (CPR) is based on a differential formulation and provides a unifying framework for these high-order schemes. Here we present a brief review of recent developments for the FR/CPR schemes as well as some pacing items.
Properties of Caputo Operator and Its Applications to Linear Fractional Differential Equations
B. R. Sontakke,
2015-05-01
Full Text Available The purpose of this paper is to demonstrate the power of two mostly used definitions for fractional differentiation, namely, the Riemann-Liouville and Caputo fractional operator to solve some linear fractionalorder differential equations. The emphasis is given to the most popular Caputo fractional operator which is more suitable for the study of differential equations of fractional order..Illustrative examples are included to demonstrate the procedure of solution of couple of fractional differential equations having Caputo operator using Laplace transformation. Itshows that the Laplace transforms is a powerful and efficient technique for obtaining analytic solution of linear fractional differential equations
Molecular properties of aqueous solutions: a focus on the collective dynamics of hydration water.
Comez, L; Paolantoni, M; Sassi, P; Corezzi, S; Morresi, A; Fioretto, D
2016-07-07
When a solute is dissolved in water, their mutual interactions determine the molecular properties of the solute on one hand, and the structure and dynamics of the surrounding water particles (the so-called hydration water) on the other. The very existence of soft matter and its peculiar properties are largely due to the wide variety of possible water-solute interactions. In this context, water is not an inert medium but rather an active component, and hydration water plays a crucial role in determining the structure, stability, dynamics, and function of matter. This review focuses on the collective dynamics of hydration water in terms of retardation with respect to the bulk, and of the number of molecules whose dynamics is perturbed. Since water environments are in a dynamic equilibrium, with molecules continuously exchanging from around the solute towards the bulk and vice versa, we examine the ability of different techniques to measure the water dynamics on the basis of the explored time scales and exchange rates. Special emphasis is given to the collective dynamics probed by extended depolarized light scattering and we discuss whether and to what extent the results obtained in aqueous solutions of small molecules can be extrapolated to the case of large biomacromolecules. In fact, recent experiments performed on solutions of increasing complexity clearly indicate that a reductionist approach is not adequate to describe their collective dynamics. We conclude this review by presenting current ideas that are being developed to describe the dynamics of water interacting with macromolecules.
Raheleh Assari
2015-01-01
Full Text Available Purpose. To compare the laboratory data and changes in these data between patients with MAS and patients with flare-up of the autoimmune diseases. Methods. In a prospective study, the static laboratory data and dynamic changes in the selected data in 17 consecutive patients with MAS and 53 patients with active disease of SJIA, PJIA, Kawasaki disease, and SLE were compared. The ROC curve analysis was used to evaluate cut-off points, sensitivity, and specificity of the static and dynamic laboratory data to differentiate between MAS and active disease. Results. In the MAS group, the mean CRP3, ALT, AST, total bilirubin, ferritin, LDH, PT, PTT, and INR were significantly higher and the mean WBC2, PMN2, Lymph2, Hgb1, 2, 3, ESR2, serum albumin, and sodium were significantly lower than in control group. Some of the important cut-off points were PLT2 38.5, ALT > 38, WBC 5277 ng/mL. Conclusion. The dynamic changes in some laboratory data, especially PLT, can differentiate between MAS and active disease. The changes in WBC, PMN, and ESR and the levels of the liver enzymes may also be helpful in the early differentiation. Very high levels of ferritin may also help the diagnosis along with other clinical and laboratory signs.
Dynamical Properties of Models for the Calvin Cycle
Rendall, Alan D.; Velázquez, Juan J. L.
2014-09-01
Modelling the Calvin cycle of photosynthesis leads to various systems of ordinary differential equations and reaction-diffusion equations. They differ by the choice of chemical substances included in the model, the choices of stoichiometric coefficients and chemical kinetics and whether or not diffusion is taken into account. This paper studies the long-time behaviour of solutions of several of these systems, concentrating on the ODE case. In some examples it is shown that there exist two positive stationary solutions. In several cases it is shown that there exist solutions where the concentrations of all substrates tend to zero at late times and others (runaway solutions) where the concentrations of all substrates increase without limit. In another case, where the concentration of ATP is explicitly included, runaway solutions are ruled out.
Thermal transport properties of uranium dioxide by molecular dynamics simulations
Watanabe, Taku; Sinnott, Susan B. [Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611 (United States); Tulenko, James S. [Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, FL 32611 (United States); Grimes, Robin W. [Department of Materials, Imperial College London, London SW7 2AZ (United Kingdom); Schelling, Patrick K. [AMPAC and Department of Physics, University of Central Florida, Orlando, FL 32816 (United States); Phillpot, Simon R. [Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611 (United States)], E-mail: sphil@mse.ufl.edu
2008-04-30
The thermal conductivities of single crystal and polycrystalline UO{sub 2} are calculated using molecular dynamics simulations, with interatomic interactions described by two different potential models. For single crystals, the calculated thermal conductivities are found to be strongly dependent on the size of the simulation cell. However, a scaling analysis shows that the two models predict essentially identical values for the thermal conductivity for infinite system sizes. By contrast, simulations with the two potentials for identical fine polycrystalline structures yield estimated thermal conductivities that differ by a factor of two. We analyze the origin of this difference.
Molecular dynamics simulation of thermodynamical properties of copper clusters
Wu Zhi-Min; Wang Xin-Qiang; Yang Yuan-Yuan
2007-01-01
The melting and freezing processes of CuN (N = 180, 256, 360, 408, 500, 628 and 736) nanoclusters are simulated by using micro-canonical molecular dynamics simulation technique. The potential energies and the heat capacities as a function of temperature are obtained. The results reveal that the melting and freezing points increase almost linearly with the atom number in the cluster increasing. All copper nanoclusters have negative heat capacity around the melting and freezing points, and hysteresis effect in the melting/freezing transition is derived in CuN nanoclusters for the first time.
Core-shell colloidal particles with dynamically tunable scattering properties.
Meng, Guangnan; Manoharan, Vinothan N; Perro, Adeline
2017-09-27
We design polystyrene-poly(N'-isopropylacrylamide-co-acrylic acid) core-shell particles that exhibit dynamically tunable scattering. We show that under normal solvent conditions the shell is nearly index-matched to pure water, and the particle scattering is dominated by Rayleigh scattering from the core. As the temperature or salt concentration increases, both the scattering cross-section and the forward scattering increase, characteristic of Mie scatterers. The magnitude of the change in the scattering cross-section and scattering anisotropy can be controlled through the solvent conditions and the size of the core. Such particles may find use as optical switches or optical filters with tunable opacity.
The World-Trade Web: Topological Properties, Dynamics, and Evolution
Fagiolo, Giorgio; Reyes, Javier; Schiavo, Stefano
2008-01-01
This paper studies the statistical properties of the web of import-export relationships among world countries using a weighted-network approach. We analyze how the distributions of the most important network statistics measuring connectivity, assortativity, clustering and centrality have co-evolved over time. We show that all node-statistic distributions and their correlation structure have remained surprisingly stable in the last 20 years -- and are likely to do so in the future. Conversely,...
A plasmonic fluid with dynamically tunable optical properties
Bhattacharjee, Rama Ranjan
2009-01-01
We report the first synthesis of a gold nanorod (GNR)-based nanocomposite that exhibits solid-like plasmonic properties while behaving in a liquid-like manner. Tuning the degree of GNR clustering controls the material\\'s responsiveness to external stimuli, such as mechanical shearing, due to the sensitivity of the localized surface plasmon resonance to interparticle interactions. © 2009 The Royal Society of Chemistry.
K.G.S. Dilrukshi
2015-07-01
Full Text Available A thorough understanding on the mechanical properties of carbon nanotube (CNT is essential in extending the advanced applications of CNT based systems. However, conducting experiments to estimate mechanical properties at this scale is extremely challenging. Therefore, development of mechanistic models to estimate the mechanical properties of CNTs along with the integration of existing continuum mechanics concepts is critically important. This paper presents a comprehensive molecular dynamics simulation study on the size dependency and potential function influence of mechanical properties of CNT. Commonly used reactive bond order (REBO and adaptive intermolecular reactive bond order (AIREBO potential functions were considered in this regard. Young’s modulus and shear modulus of CNTs are derived by integrating classical continuum mechanics concepts with molecular dynamics simulations. The results indicate that the potential function has a significant influence on the estimated mechanical properties of CNTs, and the influence of potential field is much higher when studying the torsional behaviour of CNTs than the tensile behaviour.
Yan, Shaomin [State Key Laboratory of Non-food Biomass Enzyme Technology, National Engineering Research Center for Non-food Biorefinery, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi, 530007 (China); Wu, Guang [State Key Laboratory of Non-food Biomass Enzyme Technology, National Engineering Research Center for Non-food Biorefinery, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi, 530007 (China); DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong, 518054 (China)
2012-05-15
To enhance the success rate of protein crystallization, many studies were conducted to determine the relationship between amino acid properties and the success rate of protein crystallization. Although those were successful, new efforts should be made to search for the new factors, which affect protein crystallization. In this study, two dynamic amino acid properties were used to correlate with the success rate of crystallization of proteins from Bacteroides vulgatus, because the amino acid properties used in previous studies were steady. As previously done, logistic regression and neural network were used to model that relationship, and the results were compared against those obtained from each of 532 amino acid properties, which severed as benchmark. The results demonstrated that dynamic amino acid properties should be taken into consideration of protein crystallization. (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Change of Static and Dynamic Elastic Properties due to CO² Injection in North Sea Chalk
Alam, Mohammad Monzurul; Hjuler, M.L.; Christensen, H.F.;
2012-01-01
Reservoir modeling and monitoring uses dynamic data for predicting and determining static changes. Dynamic data are achieved from the propagation velocity of elastic waves in rock while static data are obtained from the mechanical deformation. Reservoir simulation and monitoring are particularly......% non-carbonate. We studied difference in static and dynamic behavior. Furthermore, brine saturated data were compared with CO2 injected data to reveal the effect of supercritical CO2 injection in both static and dynamic elastic properties. We used strain gauges and LVDTs to measure static deformation....... We observed lower dynamic elastic modulus for chalk with higher non-carbonate content at porosities lower than 30%. In 30% porosity chalk, dynamic compressional and bulk modulus were found significantly higher than the static modulus. Static measurements with LVDT were found lowest. The effect of CO2...
Strength properties of the jointed rock mass medium under dynamic cyclic loading *
无
2001-01-01
The dynamic strength properties of the intermittently jointed mediums are studied using model test to investigate the jointed rock mass behavior under dynamic cyclic load. The model test results demonstrate that (i) the dynamic strength of the jointed samples increases with the loading frequency and decreases with the loading loops; (ii) the dynamic residual strength will not be zero like the static residual strength under one-axle loading condition; (iii) the dynamic strength changes greatly with the joint density and joint angle, and it differs from that of the static strength which reaches the lowest at an angle of 45° + ψ/2, while in the dynamic case, the lowest strength is at the angle of 45°.
Droplets in Microchannels: Dynamical Properties of the Lubrication Film.
Huerre, Axel; Theodoly, Olivier; Leshansky, Alexander M; Valignat, Marie-Pierre; Cantat, Isabelle; Jullien, Marie-Caroline
2015-08-07
We study the motion of droplets in a confined, micrometric geometry, by focusing on the lubrication film between a droplet and a wall. When capillary forces dominate, the lubrication film thickness evolves nonlinearly with the capillary number due to the viscous dissipation between the meniscus and the wall. However, this film may become thin enough (tens of nanometers) that intermolecular forces come into play and affect classical scalings. Our experiments yield highly resolved topographies of the shape of the interface and allow us to bring new insights into droplet dynamics in microfluidics. We report the novel characterization of two dynamical regimes as the capillary number increases: (i) at low capillary numbers, the film thickness is constant and set by the disjoining pressure, while (ii) above a critical capillary number, the interface behavior is well described by a viscous scenario. At a high surfactant concentration, structural effects lead to the formation of patterns on the interface, which can be used to trace the interface velocity, that yield direct confirmation of the boundary condition in the viscous regime.
General Critical Properties of the Dynamics of Scientific Discovery
Bettencourt, L. M. A. (LANL); Kaiser, D. I. (MIT)
2011-05-31
Scientific fields are difficult to define and compare, yet there is a general sense that they undergo similar stages of development. From this point of view it becomes important to determine if these superficial similarities can be translated into a general framework that would quantify the general advent and subsequent dynamics of scientific ideas. Such a framework would have important practical applications of allowing us to compare fields that superficially may appear different, in terms of their subject matter, research techniques, typical collaboration size, etc. Particularh' important in a field's history is the moment at which conceptual and technical unification allows widespread exchange of ideas and collaboration, at which point networks of collaboration show the analog of a percolation phenomenon, developing a giant connected component containing most authors. Here we investigate the generality of this topological transition in the collaboration structure of scientific fields as they grow and become denser. We develop a general theoretical framework in which each scientific field is an instantiation of the same large-scale topological critical phenomenon. We consider whether the evidence from a variety of specific fields is consistent with this picture, and estimate critical exponents associated with the transition. We then discuss the generality of the phenomenon and to what extent we may expect other scientific fields — including very large ones — to follow the same dynamics.
Dynamical properties of confined supercooled water: an NMR study
Mallamace, Francesco; Broccio, Matteo; Corsaro, Carmelo; Faraone, Antonio; Liu, Li; Mou, Chung-Yuan; Chen, Sow-Hsin
2006-09-01
We report a set of dynamical data of confined water measured in a very deeply supercooled regime (290-190 K). Water is contained in silica matrices (MCM-41-S) which consist of 1D cylindrical pores with diameters d = 14,18 and 24 Å. When confined in these tubular pores, water does not crystallize, and can be supercooled well below 200 K. We use the NMR technique to obtain the characteristic proton relaxation time-constants (the spin-lattice relaxation time-constant T1 and the spin-spin relaxation time-constant T2) and a direct measurement of the self-diffusion coefficient in the whole temperature range. We give evidence of the existence of a fragile-to-strong dynamic crossover (FSC) at TL = 225 K from the temperature dependence of the self-diffusion coefficient. A combination of the NMR self-diffusion coefficient with the average translational relaxation time, as measured by quasi-elastic neutron scattering, shows a well defined decoupling of transport coefficients, i.e. the breakdown of the Stokes-Einstein relation, on approaching the crossover temperature TL.
Dynamical properties of confined supercooled water: an NMR study
Mallamace, Francesco [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Broccio, Matteo [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Corsaro, Carmelo [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Faraone, Antonio [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Liu Li [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Mou, C-Y [Department of Chemistry, National Taiwan University, Taipei, Taiwan (China); Chen, S-H [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)
2006-09-13
We report a set of dynamical data of confined water measured in a very deeply supercooled regime (290-190 K). Water is contained in silica matrices (MCM-41-S) which consist of 1D cylindrical pores with diameters d = 14,18 and 24 A. When confined in these tubular pores, water does not crystallize, and can be supercooled well below 200 K. We use the NMR technique to obtain the characteristic proton relaxation time-constants (the spin-lattice relaxation time-constant T1 and the spin-spin relaxation time-constant T2) and a direct measurement of the self-diffusion coefficient in the whole temperature range. We give evidence of the existence of a fragile-to-strong dynamic crossover (FSC) at T{sub L} = 225 K from the temperature dependence of the self-diffusion coefficient. A combination of the NMR self-diffusion coefficient with the average translational relaxation time, as measured by quasi-elastic neutron scattering, shows a well defined decoupling of transport coefficients, i.e. the breakdown of the Stokes-Einstein relation, on approaching the crossover temperature T{sub L}.
Dynamic and static properties of the invaded cluster algorithm
Moriarty, K.; Machta, J.; Chayes, L. Y.
1999-02-01
Simulations of the two-dimensional Ising and three-state Potts models at their critical points are performed using the invaded cluster (IC) algorithm. It is argued that observables measured on a sublattice of size l should exhibit a crossover to Swendsen-Wang (SW) behavior for l sufficiently less than the lattice size L, and a scaling form is proposed to describe the crossover phenomenon. It is found that the energy autocorrelation time τɛ(l,L) for an l×l sublattice attains a maximum in the crossover region, and a dynamic exponent zIC for the IC algorithm is defined according to τɛ,max~LzIC. Simulation results for the three-state model yield zIC=0.346+/-0.002, which is smaller than values of the dynamic exponent found for the SW and Wolff algorithms and also less than the Li-Sokal bound. The results are less conclusive for the Ising model, but it appears that zICWolff algorithms.
Computer simulation of some dynamical properties of the Lorentz gas
Joslin, C. G.; Egelstaff, P. A.
1989-07-01
We carried out molecular dynamics simulations of a Lorentz gas, consisting of a lone hydrogen molecule moving in a sea of stationary argon atoms. A Lennard-Jones form was assumed for the H2-Ar potential. The calculations were performed at a reduced temperature K * = kT/ɛH 2-Ar = 4.64 and at reduced densities ρ *= ρ Arσ{Ar/3} in the range 0.074-0.414. The placement of Ar atoms was assumed to be random rather than dictated by equilibrium considerations. We followed the trajectories of many H2 molecules, each of which is assigned in turn a velocity given by the Maxwell-Boltzmann distribution at the temperature of the simulation. Solving the equations of motion classically, we obtained the translational part of the incoherent dynamic structure factor for the H2 molecule, S tr( q, ω). This was convoluted with the rotational structure factor S rot( q, ω) calculated assuming unhindered rotation to obtain the total structure factor S( q, ω). Our results agree well with experimental data on this function obtained by Egelstaff et al. At the highest density ( ρ *=0.414) we studied the dependence of S( q, ω) on system size (number of Ar atoms), number of H2 molecules for which trajectories are generated, and the length of time over which these trajectories are followed.
Jacob J Setterbo
Full Text Available BACKGROUND: Racetrack surface is a risk factor for racehorse injuries and fatalities. Current research indicates that race surface mechanical properties may be influenced by material composition, moisture content, temperature, and maintenance. Race surface mechanical testing in a controlled laboratory setting would allow for objective evaluation of dynamic properties of surface and factors that affect surface behavior. OBJECTIVE: To develop a method for reconstruction of race surfaces in the laboratory and validate the method by comparison with racetrack measurements of dynamic surface properties. METHODS: Track-testing device (TTD impact tests were conducted to simulate equine hoof impact on dirt and synthetic race surfaces; tests were performed both in situ (racetrack and using laboratory reconstructions of harvested surface materials. Clegg Hammer in situ measurements were used to guide surface reconstruction in the laboratory. Dynamic surface properties were compared between in situ and laboratory settings. Relationships between racetrack TTD and Clegg Hammer measurements were analyzed using stepwise multiple linear regression. RESULTS: Most dynamic surface property setting differences (racetrack-laboratory were small relative to surface material type differences (dirt-synthetic. Clegg Hammer measurements were more strongly correlated with TTD measurements on the synthetic surface than the dirt surface. On the dirt surface, Clegg Hammer decelerations were negatively correlated with TTD forces. CONCLUSIONS: Laboratory reconstruction of racetrack surfaces guided by Clegg Hammer measurements yielded TTD impact measurements similar to in situ values. The negative correlation between TTD and Clegg Hammer measurements confirms the importance of instrument mass when drawing conclusions from testing results. Lighter impact devices may be less appropriate for assessing dynamic surface properties compared to testing equipment designed to simulate hoof
Dimitrova, Zlatinka I
2013-01-01
We present a brief overview of integrability of nonlinear ordinary and partial differential equations with a focus on the Painleve property: an ODE of second order has the Painleve property if the only movable singularities connected to this equation are single poles. The importance of this property can be seen from the Ablowitz-Ramani-Segur conhecture that states that a nonlinear PDE is solvable by inverse scattering transformation only if each nonlinear ODE obtained by exact reduction of this PDE has the Painleve property. The Painleve property motivated motivated much research on obtaining exact solutions on nonlinear PDEs and leaded in particular to the method of simplest equation. A version of this method called modified method of simplest equation is discussed below.
Interpreting experimental data on egg production - applications of dynamic differential equations
France, J.; Lopez, S.; Kebreab, E.; Dijkstra, J.
2013-01-01
This contribution focuses on applying mathematical models based on systems of ordinary first-order differential equations to synthesize and interpret data from egg production experiments. Models based on linear systems of differential equations are contrasted with those based on nonlinear systems.
Stability properties of nonlinear dynamical systems and evolutionary stable states
Gleria, Iram, E-mail: iram@fis.ufal.br [Instituto de Física, Universidade Federal de Alagoas, 57072-970 Maceió-AL (Brazil); Brenig, Leon [Faculté des Sciences, Université Libre de Bruxelles, 1050 Brussels (Belgium); Rocha Filho, Tarcísio M.; Figueiredo, Annibal [Instituto de Física and International Center for Condensed Matter Physics, Universidade de Brasília, 70919-970 Brasília-DF (Brazil)
2017-03-18
Highlights: • We address the problem of equilibrium stability in a general class of non-linear systems. • We link Evolutionary Stable States (ESS) to stable fixed points of square quasi-polynomial (QP) systems. • We show that an interior ES point may be related to stable interior fixed points of QP systems. - Abstract: In this paper we address the problem of stability in a general class of non-linear systems. We establish a link between the concepts of asymptotic stable interior fixed points of square Quasi-Polynomial systems and evolutionary stable states, a property of some payoff matrices arising from evolutionary games.
Properties of hot liquid cerium by LDA + U molecular dynamics.
Siberchicot, Bruno; Clérouin, Jean
2012-11-14
We present ab initio simulations of liquid cerium in the framework of the LDA + U formulation. The liquid density has been determined self-consistently by searching for the zero pressure equilibrium state at 1320 K with the same set of parameters (U and J) and occupation matrices as those optimized for the γ phase. We have computed static and transport properties. The liquid produced by the simulations appears more structured than the available measurements. This raises questions regarding the ability of the theory to describe such a complex liquid. Conductivity calculations and temperature dependences are nevertheless in reasonable agreement with data.
Khayamian, T; Ensafi, Ali A; Benvidi, A
2006-07-15
A wavelet neural network (WNN) model is proposed for extending the dynamic range of Cu(II) determination by differential pulse adsorption cathodic stripping voltammetry (DP-AdSV) using xylenol orange (XO) as a suitable ligand. All of voltammograms data consisting of Cu(II) and Cu(II)-XO peak currents were used in WNN model. The WNN model consisted of three layers (2-8-1) with the Morlet mother wavelet transfer function in the hidden layer. The model was able to extend the dynamic range of Cu(II) from its narrow linear range (1-50 ng ml(-1)) to the higher dynamic range (1-1500 ng ml(-1)). The results of the WNN model was also compared with artificial neural network (ANN) model and it was demonstrated the superiority of the WNN model relative to ANN model.
Barber, Benjamin A; Liyanage, Vichithra R B; Zachariah, Robby M; Olson, Carl O; Bailey, Melissa A G; Rastegar, Mojgan
2013-10-01
Central nervous system development is controlled by highly conserved homeoprotein transcription factors including HOX and TALE (Three Amino acid Loop Extension). TALE proteins are primarily known as HOX-cofactors and play key roles in cell proliferation, differentiation and organogenesis. MEIS1 is a TALE member with established expression in the developing central nervous system. MEIS1 is essential for embryonic development and Meis1 knockout mice dies at embryonic day (E) 14.5. However, Meis1/MEIS1 expression in the devolving forebrain, at this critical time-point has not been studied. Here, for the first time we characterize the region-specific expression of MEIS1 in E14.5 mouse forebrain, filling the gap of MEIS1 expression profile between E12.5 and E16.5. Previously, we reported MEIS1 transcriptional regulatory role in neuronal differentiation and established forebrain-derived neural stem cells (NSC) for gene therapy application of neuronal genes. Here, we show the dynamic expression of Meis1/MEIS1 during the differentiation of forebrain-derived NSC toward a glial lineage. Our results show that Meis1/MEIS1 expression is induced during NSC differentiation and is expressed in both differentiated neurons and astrocytes. Confirming these results, we detected MEIS1 expression in primary cultures of in vivo differentiated cortical neurons and astrocytes. We further demonstrate Meis1/MEIS1 expression relative to other TALE family members in the forebrain-derived NSC in the absence of Hox genes. Our data provide evidence that forebrain-derived NSC can be used as an accessible in vitro model to study the expression and function of TALE proteins, supporting their potential role in modulating NSC self-renewal and differentiation.
Burke Les J
2007-10-01
Full Text Available Abstract Background Expression profiling of embryonic stem (ES cell differentiation in the presence of serum has been performed previously. It remains unclear if transcriptional activation is dependent on complex growth factor mixtures in serum or whether this process is intrinsic to ES cells once the stem cell program has been inactivated. The aims of this study were to determine the transcriptional programs associated with the stem cell state and to characterize mesoderm differentiation between serum and serum-free culture. Results ES cells were differentiated as embryoid bodies in 10% FBS or serum-free media containing BMP4 (2 ng/ml, and expression profiled using 47 K Illumina(R Sentrix arrays. Statistical methods were employed to define gene sets characteristic of stem cell, epiblast and primitive streak programs. Although the initial differentiation profile was similar between the two culture conditions, cardiac gene expression was inhibited in serum whereas blood gene expression was enhanced. Also, expression of many members of the Kruppel-like factor (KLF family of transcription factors changed dramatically during the first few days of differentiation. KLF2 and KLF4 co-localized with OCT4 in a sub-nuclear compartment of ES cells, dynamic changes in KLF-DNA binding activities occurred upon differentiation, and strong bio-informatic evidence for direct regulation of many stem cell genes by KLFs was found. Conclusion Down regulation of stem cell genes and activation of epiblast/primitive streak genes is similar in serum and defined media, but subsequent mesoderm differentiation is strongly influenced by the composition of the media. In addition, KLF family members are likely to be important regulators of many stem cell genes.
Compliant Foil Journal Bearings - Investigation of Dynamic Properties
Larsen, Jon Steffen; Santos, Ilmar
a Bubnow-Galerkin approach. This constitutes the main original contribution of this work, considering the fact that the finite difference method is commonly used and thouroughly investigated in the literature. The finite element method leads to a set of non-linear equations for the static fluid film....../compliance of the foil structure is presented. The compliance of the foil structure is incorporated implicitly in the Reynolds equation which is accomplished through a modification of the film gap function [8]. The resulting non-linear equation is perturbed and solved by use of the finite element method following...... and dynamic coefficients, of the compliant foil bearing together with an efficient solution method, which can be easily adopted and implemented by mechanical engineers. A theoretical model of a radial compliant foil bearing that incorporates compressibility of the lubricating gas and flexibility...
Dynamical properties of nimodipine molecules confined in SBA-15 matrix
Kiwilsza, A.; Pajzderska, A.; Mielcarek, J.; Jenczyk, J.; Wąsicki, J.
2016-08-01
The paper reports results of 13C and 1H ssNMR for nimodipine confined in mesopores of SBA-15 for the samples (i) containing nimodipine molecules inside and on the external surface of silica, (ii) containing nimodipine only inside pores forming an incomplete monolayer on the surface (iii) for bulk nimodipine. The measurements permitted comparison of the dynamics of nimodipine bulk and confined in pores. The confined nimodipine is in an amorphous state and has additional degrees of rotational freedom with respect to the bulk one. The height of the energy barrier related to the rotation of methyl groups in confined nimodipine is lower than in bulk nimodipine. The higher mobility of nimodipine molecules confined in silica pores can explain the higher release rate of nimodipine from silica matrix than dissolution rate of bulk drug.
Effects of Thermal Treatment on the Dynamic Mechanical Properties of Coal Measures Sandstone
Li, Ming; Mao, Xianbiao; Cao, Lili; Pu, Hai; Mao, Rongrong; Lu, Aihong
2016-09-01
Many projects such as the underground gasification of coal seams and coal-bed methane mining (exploitation) widely involve the dynamic problems of coal measures sandstone achieved via thermal treatment. This study examines the dynamic mechanical properties of coal measures sandstone after thermal treatment by means of an MTS653 high-temperature furnace and Split Hopkinson pressure bar test system. Experimental results indicate that 500 °C is a transition point for the dynamic mechanical parameters of coal measures sandstone. The dynamic elastic modulus and peak strength increase linearly from 25 to 500 °C while the dynamic peak strain decreases linearly over the same temperature range. The dynamic elastic modulus and peak strength drop quickly from 500 to 800 °C, with a significant increase in the dynamic peak strain over the same temperature range. The rock mechanics are closely linked to material composition and mesoscopic structure. Analysis by X-ray diffraction and scanning electron microscopy indicate that the molecules inside the sandstone increase in density due to the thermal expansion of the material particles, which effectively improves the deformation resistance and carrying capacity of the sandstone and reduces the likelihood of axial deformation. With heat treatment that exceeds 500 °C, the dynamic mechanical properties rapidly weaken due to the decomposition of kaolinite; additionally, hot cracking of the mineral particles within the materials arises from coal sandstone internal porosity, and other defects gradually appear.
Ji, Pengfei; Yang, Mo
2016-01-01
The structural, dynamic, and vibrational properties during the heat transfer process in Si/Ge superlattices, are studied by analyzing the trajectories generated by the ab initio Car-Parrinello molecular dynamics simulation. The radial distribution functions and mean square displacements are calculated and further discussions are made to explain and probe the structural changes relating to the heat transfer phenomenon. Furthermore, the vibrational density of states of the two layers (Si/Ge) are computed and plotted to analyze the contributions of phonons with different frequencies to the heat conduction. Coherent heat conduction of the low frequency phonons is found and their contributions to facilitate heat transfer are confirmed. The Car-Parrinello molecular dynamics simulation outputs in the work show reasonable thermophysical results of the thermal energy transport process and shed light on the potential applications of treating the heat transfer in the superlattices of semiconductor materials from a quant...
Diez-Pascual, A M; Naffakh, M; Gomez, M A; Marco, C; Ellis, G [Departamento de Fisica e Ingenieria de Polimeros, Instituto de Ciencia y Tecnologia de Polimeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid (Spain); Gonzalez-Dominguez, J M; Anson, A; MartInez, M T [Instituto de Carboquimica, CSIC, c/Miguel Luesma Castan 4, 50018 Zaragoza (Spain); MartInez-Rubi, Y; Simard, B [Steacie Institute for Molecular Sciences, NRC, 100 Sussex Drive, Ottawa (Canada); Ashrafi, B, E-mail: adiez@ictp.csic.e [Institute for Aerospace Research, NRC, 1200 Montreal Road, Ottawa (Canada)
2009-08-05
The effect of polyetherimide (PEI) as a compatibilizing agent on the morphology, thermal, electrical and dynamic mechanical properties of poly(ether ether ketone) (PEEK)/single-walled carbon nanotube (SWCNT) nanocomposites, has been investigated for different CNT loadings. After a pre-processing step based on ball milling and pre-mixing under mechanical treatment in ethanol, the samples were prepared by melt extrusion. A more homogeneous distribution of the CNTs throughout the matrix is found for composites containing PEI, as revealed by scanning electron microscopy. Thermogravimetric analysis demonstrates an increase in the matrix degradation temperatures under dry air and nitrogen atmospheres with the addition of SWCNTs; the level of thermal stability of these nanocomposites is maintained when PEI is incorporated. Both differential scanning calorimetry and synchrotron x-ray scattering studies indicate a slight decrease in the crystallization temperatures of the compatibilized samples, and suggest the existence of reorganization phenomena during the heating, which are favoured in the composites incorporating the compatibilizer, due to their smaller crystal size. Dynamic mechanical studies show an increase in the glass transition temperature of the nanocomposites upon the addition of PEI. Furthermore, the presence of PEI causes an enhancement in the storage modulus, and hence in the rigidity of these systems, attributed to an improved interfacial adhesion between the reinforcement and the matrix. The electrical and thermal conductivities of these composites decrease with the incorporation of PEI. Overall, the compatibilized samples exhibit improved properties and are promising for their use in industrial applications.
Dynamical properties of a dissipative discontinuous map: A scaling investigation
Aguilar-Sánchez, R. [Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla 72570 (Mexico); Leonel, Edson D. [Departamento de Física, UNESP – Univ. Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900 Rio Claro, SP (Brazil); Méndez-Bermúdez, J.A. [Instituto de Física, Benemérita Universidad Autónoma de Puebla, Apartado Postal J-48, Puebla 72570 (Mexico)
2013-12-13
The effects of dissipation on the scaling properties of nonlinear discontinuous maps are investigated by analyzing the behavior of the average squared action 〈I{sup 2}〉 as a function of the n-th iteration of the map as well as the parameters K and γ, controlling nonlinearity and dissipation, respectively. We concentrate our efforts to study the case where the nonlinearity is large; i.e., K≫1. In this regime and for large initial action I{sub 0}≫K, we prove that dissipation produces an exponential decay for the average action 〈I〉. Also, for I{sub 0}≅0, we describe the behavior of 〈I{sup 2}〉 using a scaling function and analytically obtain critical exponents which are used to overlap different curves of 〈I{sup 2}〉 onto a universal plot. We complete our study with the analysis of the scaling properties of the deviation around the average action ω.
Dynamic viscoelastic properties of collagen gels with high mechanical strength.
Mori, Hideki; Shimizu, Kousuke; Hara, Masayuki
2013-08-01
We developed a new method for the preparation of mechanically strong collagen gels by combining successively basic gel formation, followed by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) cross-linking and lyophilization. Gels cross-linked three times with this method showed stronger mechanical properties (G': 3730±2060 Pa, G″: 288±35 Pa) than a conventional gel that was sequentially cross-linked with EDC once (G': 226±70 Pa, G″: 21±4.4 Pa), but not as strong as the same gel with heating for 30 min at 80°C (G': 7010±830 Pa, G″: 288±35 Pa) reported in our previous paper. The conventional collagen gel was cross-linked with EDC once, heated once, and then subjected twice to a lyophilization-gel formation-cross-linking cycle to give three-cycled gel 2. This gel had the strongest mechanical properties (G': 40,200±18,000 Pa, G″: 3090±1400 Pa, Young's modulus: 0.197±0.069 MPa) of the gels tested. These promising results suggest possible applications of the gels as scaffolds in tissue engineering research.
ZHANG Yongzhi
2016-10-01
Full Text Available A dynamic fuzzy RBF neural network model was built to predict the mechanical properties of welded joints, and the purpose of the model was to overcome the shortcomings of static neural networks including structural identification, dynamic sample training and learning algorithm. The structure and parameters of the model are no longer head of default, dynamic adaptive adjustment in the training, suitable for dynamic sample data for learning, learning algorithm introduces hierarchical learning and fuzzy rule pruning strategy, to accelerate the training speed of model and make the model more compact. Simulation of the model was carried out by using three kinds of thickness and different process TC4 titanium alloy TIG welding test data. The results show that the model has higher prediction accuracy, which is suitable for predicting the mechanical properties of welded joints, and has opened up a new way for the on-line control of the welding process.
Ma, Yanhong; Zhang, Qicheng; Zhang, Dayi; Hu, Wenzhong; Hong, Jie
2017-05-01
This work describes the dynamic characteristics of a novel soft magnetic entangled metallic wire material(SM-EMWM) by the dynamic tests for the first time. The mechanical properties of three batches of SM-EMWMs with different porosities have been investigated under different dynamic loads in different magnetic field intensities. The result shows that its properties (storage modulus and loss factor) have commendably controllable magnetic responses in the magnetic field. In particular, the dynamic damping is more remarkable than its quasi-static performance, and the loss factor can be improved above 50% in the magnetic field of 500 mT. The results indicate that SM-EMWM as a magneto-sensitive smart material possesses a considerable application prospect for the active vibration control with variable stiffness and damping.
Effects of Temperature and Strain Rate on Dynamic Properties of Concrete
JIA Bin; TAO Junlin; LI Zhengliang; WANG Ruheng; ZHANG Yu
2008-01-01
To study the dynamic properties of the concrete subjected to impulsive loading,stress-time curves of concrete in different velocities were measured using split Hopkinson pressure bar (SHPB).Effects of temperature and strain rate on the dynamic yield strength and constitutive relation of the concrete were analyzed.The dynamic mechanical properties of the reinforced concrete are subjected to high strain rates when it is at a relatively low temperature.But with temperature increasing,the temperature softening effect makes the strength of the concrete weaken and the impact toughness of the concrete is saliently relative to strain rate effect.So,strain rate effect,strain hardening and temperature softening work together on the dynamic mechanical capability of concrete and the relation between them is relatively corn plex.
Lina Cui
Full Text Available Despite the extensive hepatic differentiation potential of human umbilical cord lining-derived mesenchymal stem cells (hUC-MSC, little is known about the molecular mechanisms of hUC-MSC differentiation. At the post-transcriptional level, microRNAs are key players in the control of cell fate determination during differentiation. In this study, we aimed to identify microRNAs involved in the hepatic differentiation of hUC-MSCs. After successfully isolating hUC- MSCs, we induced hepatocyte formation in vitro with growth factors. After 26 days of induction, hUC-MSCs could express hepatocyte-specific genes, synthesize urea and glycogen and uptake low-density lipoprotein. Cellular total RNA from hUC-MSCs and hepatic differentiated hUC-MSCs was collected at 7 time points, including 2 days, 6 days, 10 days, 14 days, 22 days and 26 days, for microRNA microarray analysis. Dynamic microRNA profiles were identified that did not overlap or only partially overlapped with microRNAs reported to be involved in human liver development, hepatocyte regeneration or hepatic differentiation of liver-derived progenitor cells. A total of 61 microRNAs among 1205 human and 144 human viral microRNAs displayed consistent changes and were altered at least 2-fold between hUC-MSCs and hepatic differentiated hUC-MSCs. Among these microRNAs, 25 were over-expressed; this over-expression occurred either gradually or increased sharply and was maintained at a high level. A total of 36 microRNAs were under-expressed, with an expression pattern similar to that of the over-expressed microRNAs. The expression of the altered expressed microRNAs was also confirmed by quantitative reverse-transcription polymerase chain reaction. We also found that microRNAs involved in hepatic differentiation were not enriched in hepatocyte or hepatocellular carcinoma cells and can potentially target liver-enriched transcription factors and genes. The elucidation of the microRNA profile during the hepatic
Dynamic properties of the cubic nonlinear Schr(o)dinger equation by symplectic method
Liu Xue-Shen; Wei Jia-Yu; Ding Pei-Zhu
2005-01-01
The dynamic properties of a cubic nonlinear Schrodinger equation are investigated numerically by using the symplectic method with different space approximations. The behaviours of the cubic nonlinear Schrodinger equation are discussed with different cubic nonlinear parameters in the harmonically modulated initial condition. We show that the conserved quantities will be preserved for long-time computation but the system will exhibit different dynamic behaviours in space difference approximation for the strong cubic nonlinearity.
STUDY OF DYNAMIC MECHANICAL PROPERTIES OF FUSED DEPOSITION MODELLING PROCESSED ULTEM MATERIAL
Adhiyamaan Arivazhagan; Ammar Saleem; S. H. Masood; Mostafa Nikzad; K. A. JAGADEESH
2014-01-01
Fused Deposition Modelling (FDM), a renowned Rapid Prototyping (RP) process, has been successfully implemented in several industries to fabricate concept models and prototypes for rapid manufacturing. This study furnishes terse notes about the material damping properties of FDM made ULTEM samples considering the effect of FDM process parameters. Dynamic Mechanical Analysis (DMA) is carried out using DMA 2980 equipment to study the dynamic response of the FDM material subjected to single canti...
Transformation properties and third-order aberrations of thin dynamic χ(2) holograms
Miloglyadov, E. V.; Stasel'ko, D. I.
2016-07-01
The results of a theoretical study of the transformation properties of thin dynamic χ(2) holograms for all frequency mixing versions are generalized, and a general pattern of transformations of reconstructed images (recorded and read at different frequencies) is developed. The principles of ray geometric construction of reconstructed images are determined. The theory of thin dynamic χ(2) holograms is extended to the range of third-order aberrations.
Guangyu Chen
2014-01-01
Full Text Available An improved differential evolution (DE method based on the dynamic search strategy (IDEBDSS is proposed to solve dynamic economic dispatch problem with valve-point effects in this paper. The proposed method combines the DE algorithm with the dynamic search strategy, which improves the performance of the algorithm. DE is the main optimizer in the method proposed. While chaotic sequences are applied to obtain the dynamic parameter settings in DE, dynamic search strategy which consists of two steps, global search strategy and local search strategy, is used to improve algorithm efficiency. To accelerate convergence, a new infeasible solution handing method is adopted in the local search strategy; meanwhile, an orthogonal crossover (OX operator is added to the global search strategy to enhance the optimization search ability. Finally, the feasibility and effectiveness of the proposed methods are demonstrated by three test systems, and the simulation results reveal that the IDEBDSS method can obtain better solutions with higher efficiency than the standard DE and other methods reported in the recent literature.
Topology of Branched Polymers: Effect on Structure and Dynamic Properties
Ramachandran, Ramnath; Beaucage, Gregory; Kulkarni, Amit S.; Galiatsatos, Vassilios; McFaddin, Douglas C.
2008-03-01
We investigated linear and branched polyethylene (PE) using small-angle neutron scattering (SANS). The experiments were conducted on dilute solutions of PE in deuterated p-xylene. A variety of structural information^ such as fractal dimension (df), connectivity dimension (c), minimum path dimension (dmin), long chain branch fraction (φbr), radius of gyration (Rg) and persistence length (lp) were obtained. Such information presents a qualitative and quantitative assessment of branching in polymers. Theoretical models such as `binary contacts per pervaded volume' model^* were employed to correlate the structural information of the polymer to its entanglement molecular weight (Me). Me was used to predict physical properties of the polymer such as plateau modulus (GN^0 ) and zero-shear viscosity (η0). ^Beaucage G. Physical Review E 70,031401 (2004) ^*Colby et al. Macromolecules 25, p.996 (1992)
Molecular dynamics simulations on surface properties of silicon dioxide melts
Röder, A
2000-01-01
In the present thesis the surface properties of a silicon dioxide melt were studied. As first systems drops (i.e. sytems without periodic boundary conditions) of N=432, 1536, as well as 4608 atoms were considered. The second analyzed geometry corresponds to that of a thin film, i. e. periodic boundary conditions in x- and y-direction were present, while in z-direction one had a free surface. In this case a system of N=1152 atoms was considered. As model potential the two-body potential proposed by Beest, Kramer, and van Santen was applied. For both geometries five temperatures were considered, which lied in the range of 3000 K
Grauer, Jared A.; Morelli, Eugene A.
2013-01-01
A nonlinear simulation of the NASA Generic Transport Model was used to investigate the effects of errors in sensor measurements, mass properties, and aircraft geometry on the accuracy of dynamic models identified from flight data. Measurements from a typical system identification maneuver were systematically and progressively deteriorated and then used to estimate stability and control derivatives within a Monte Carlo analysis. Based on the results, recommendations were provided for maximum allowable errors in sensor measurements, mass properties, and aircraft geometry to achieve desired levels of dynamic modeling accuracy. Results using other flight conditions, parameter estimation methods, and a full-scale F-16 nonlinear aircraft simulation were compared with these recommendations.
Investigation of dynamic properties of erbium fiber laser for ultrasonic sensing.
Wu, Qi; Okabe, Yoji; Sun, Junqiang
2014-04-07
Dynamic properties of an erbium fiber laser (EFL) is researched and demonstrated for ultrasonic sensing in this research. The EFL has ring cavity incorporated with a phase-shifted fiber Bragg grating. A numerical model is used to analyze its dynamic responses to quasi-static change, continuous wave and burst wave. The ultrasonic behavior of the EFL resembles the forced single degree of freedom vibration with damping. Corresponding experimental results fit the simulation results well, showing some interesting ultrasonic properties of this EFL. After certain data process method, this EFL can be used in practical ultrasonic nondestructive testing.
Impact and dynamic mechanical thermal properties of textile silk reinforced epoxy resin composites
Yang, K.; Guan, J.
2016-07-01
Silk fabric reinforced epoxy resin composites (SFRPs) were prepared using simple techniques of hand lay-up, hot-press and vacuum treatment, and a series of volume fractions of silk reinforcements were achieved. The impact properties and dynamic mechanical properties of SFRPs were investigated using a pendulum impact testing method and dynamic mechanical thermal analysis (DMTA). The results suggest that silk reinforcement could greatly enhance the mechanical performances of SFRPs. The impact strength reached a maximum of 71 kJ/m2 for 60%-silk SFRP, which demonstrated a potential of silk composites for defence and impact- resistant materials.
Mechanical, Thermal and Dynamic Mechanical Properties of PP/GF/xGnP Nanocomposites
Ashenai Ghasemi, F.; Ghorbani, A.; Ghasemi, I.
2017-03-01
The mechanical, thermal, and dynamic mechanical properties of ternary nanocomposites based on polypropylene, short glass fibers, and exfoliated graphene nanoplatelets were studied. To investigate the mechanical properties, uniaxial tensile and Charpy impact tests were carried out. To study the crystallinity of the compositions, a DSC test was performed. A dynamic mechanical analysis was used to characterize the storage modulus and loss factor (tan δ). The morphology of the composites was studied by a scanning electron microscope (SEM). The results obtained are presented in tables and graphics.
Mourragui, Mustapha
2011-01-01
We consider a boundary driven exclusion process associated to particles evolving under Kawasaki (conservative) dynamics and long range interaction in a regime in which at equilibrium phase separation might occur. We show that the empirical density under the diffusive scaling solves a non linear integro differential evolution equation with Dirichlet boundary conditions and we prove the associated dynamical large deviations principle. Further, tuning suitable the intensity of the interaction, in the uniqueness phase regime, we show that under the stationary measure the empirical density solves a non local, stationary, transport equation.
Horsch, Martin T; Vrabec, Jadran; Glass, Colin W; Niethammer, Christoph; Bernreuther, Martin F; Müller, Erich A; Jackson, George
2011-01-01
Curved fluid interfaces are investigated on the nanometre length scale by molecular dynamics simulation. Thereby, droplets surrounded by a metastable vapour phase are stabilized in the canonical ensemble. Analogous simulations are conducted for cylindrical menisci separating vapour and liquid phases under confinement in planar nanopores. Regarding the emergence of nanodroplets during nucleation, a non-equilibrium phenomenon, both the non-steady dynamics of condensation processes and stationary quantities related to supersaturated vapours are considered. Results for the truncated and shifted Lennard-Jones fluid and for mixtures of quadrupolar fluids confirm the applicability of the capillarity approximation and the classical nucleation theory.
Wang, Yuliang; Wang, Huimin; Bi, Shusheng; Guo, Bin
2016-07-25
The dynamic wetting properties of atomic force microscopy (AFM) tips are of much concern in many AFM-related measurement, fabrication, and manipulation applications. In this study, the wetting properties of silicon and silicon nitride AFM tips are investigated through dynamic contact angle measurement using a nano-Wilhelmy balance based method. This is done by capillary force measurement during extension and retraction motion of AFM tips relative to interfacial nanobubbles. The working principle of the proposed method and mathematic models for dynamic contact angle measurement are presented. Geometric models of AFM tips were constructed using scanning electronic microscopy (SEM) images taken from different view directions. The detailed process of tip-nanobubble interaction was investigated using force-distance curves of AFM on nanobubbles. Several parameters including nanobubble height, adhesion and capillary force between tip and nanobubbles are extracted. The variation of these parameters was studied over nanobubble surfaces. The dynamic contact angles of the AFM tips were calculated from the capillary force measurements. The proposed method provides direct measurement of dynamic contact angles for AFM tips and can also be taken as a general approach for nanoscale dynamic wetting property investigation.
Nanocrystalline silicon: lattice dynamics and enhanced thermoelectric properties.
Claudio, Tania; Stein, Niklas; Stroppa, Daniel G; Klobes, Benedikt; Koza, Michael Marek; Kudejova, Petra; Petermann, Nils; Wiggers, Hartmut; Schierning, Gabi; Hermann, Raphaël P
2014-12-21
Silicon has several advantages when compared to other thermoelectric materials, but until recently it was not used for thermoelectric applications due to its high thermal conductivity, 156 W K(-1) m(-1) at room temperature. Nanostructuration as means to decrease thermal transport through enhanced phonon scattering has been a subject of many studies. In this work we have evaluated the effects of nanostructuration on the lattice dynamics of bulk nanocrystalline doped silicon. The samples were prepared by gas phase synthesis, followed by current and pressure assisted sintering. The heat capacity, density of phonons states, and elastic constants were measured, which all reveal a significant, ≈25%, reduction in the speed of sound. The samples present a significantly decreased lattice thermal conductivity, ≈25 W K(-1) m(-1), which, combined with a very high carrier mobility, results in a dimensionless figure of merit with a competitive value that peaks at ZT≈ 0.57 at 973 °C. Due to its easily scalable and extremely low-cost production process, nanocrystalline Si prepared by gas phase synthesis followed by sintering could become the material of choice for high temperature thermoelectric generators.
Dynamical properties and search of variable stars: NGC 1960
Joshi, Gireesh C
2015-01-01
The total-to-selective extinction RV in the direction of a cluster is found to be 3.12 +/- 0.2 (close to its normal value). We derive the luminosity and mass functions for the cluster main sequence stars. The mass function slope is found to be -2.29 +/- 0.20 which is close to Salpeter value. We find evidence of mass segregation process in the cluster which is not yet dynamically relaxed. We have performed time series photometric observations to detect variable stars within star cluster NGC 1960. The DAOPHOT-II package is utilized to estimate the apparent stellar magnitudes of stars. The secondary standardization method is applied to the transformation of these apparent magnitudes into standard values. The magnitude-time diagrams (light curves) of stars are constructed to identify possible variability nature within them. The stars, having sufficient magnitude variation with time, are considered to be variable stars and their period values have computed through PERIOD04 package. These periodic values of variabl...
Some Properties of Solutions of a Functional-Differential Equation of Second Order with Delay
Veronica Ana Ilea
2014-01-01
Full Text Available Existence, uniqueness, data dependence (monotony, continuity, and differentiability with respect to parameter, and Ulam-Hyers stability results for the solutions of a system of functional-differential equations with delays are proved. The techniques used are Perov’s fixed point theorem and weakly Picard operator theory.
Jiang, S C; Zhang, X X
2005-01-01
A two-dimensional model including the effects of dynamic changes in the physical properties on tissue temperature and damage was developed to describe laser energy transport, heat transfer, and damage accumulation during laser-induced interstitial thermotherapy (LITT). The Monte Carlo method was used to simulate photon transport in a tissue in the nonuniform optical property field, with the finite difference method used to solve the Pennes bioheat equation to calculate the temperature distribution and the Arrhenius equation used to predict the extent of thermal damage. The numerical results showed that the dynamic changes in the optical properties, thermal properties, and blood perfusion rate significantly affected damage volume accumulation and temperature history and should be included in numerical simulations of the LITT treatment.
Gargiulo, Gaetano; Levy, Samuel; Bucci, Gabriele; Romanenghi, Mauro; Fornasari, Lorenzo; Beeson, Karen Y; Goldberg, Susanne M; Cesaroni, Matteo; Ballarini, Marco; Santoro, Fabio; Bezman, Natalie; Frigè, Gianmaria; Gregory, Philip D; Holmes, Michael C; Strausberg, Robert L; Pelicci, Pier Giuseppe; Urnov, Fyodor D; Minucci, Saverio
2009-03-01
It is well established that epigenetic modulation of genome accessibility in chromatin occurs during biological processes. Here we describe a method based on restriction enzymes and next-generation sequencing for identifying accessible DNA elements using a small amount of starting material, and use it to examine myeloid differentiation of primary human CD34+ cells. The accessibility of several classes of cis-regulatory elements was a predictive marker of in vivo DNA binding by transcription factors, and was associated with distinct patterns of histone posttranslational modifications. We also mapped large chromosomal domains with differential accessibility in progenitors and maturing cells. Accessibility became restricted during differentiation, correlating with a decreased number of expressed genes and loss of regulatory potential. Our data suggest that a permissive chromatin structure in multipotent cells is progressively and selectively closed during differentiation, and illustrate the use of our method for the identification of functional cis-regulatory elements.
Heli, Hossein; Gobal, Fereydoon
2016-01-01
.... The current-charge curves in the anodic cycles fit the logistic differential equation reasonably well and are accounted on the basis of the non-linearity of the kinetics and the effect of positive feedback...
Yu, Rong; Zhong, Weifeng; Xie, Shengli; Zhang, Yan; Zhang, Yun
2016-02-01
As the next-generation power grid, smart grid will be integrated with a variety of novel communication technologies to support the explosive data traffic and the diverse requirements of quality of service (QoS). Cognitive radio (CR), which has the favorable ability to improve the spectrum utilization, provides an efficient and reliable solution for smart grid communications networks. In this paper, we study the QoS differential scheduling problem in the CR-based smart grid communications networks. The scheduler is responsible for managing the spectrum resources and arranging the data transmissions of smart grid users (SGUs). To guarantee the differential QoS, the SGUs are assigned to have different priorities according to their roles and their current situations in the smart grid. Based on the QoS-aware priority policy, the scheduler adjusts the channels allocation to minimize the transmission delay of SGUs. The entire transmission scheduling problem is formulated as a semi-Markov decision process and solved by the methodology of adaptive dynamic programming. A heuristic dynamic programming (HDP) architecture is established for the scheduling problem. By the online network training, the HDP can learn from the activities of primary users and SGUs, and adjust the scheduling decision to achieve the purpose of transmission delay minimization. Simulation results illustrate that the proposed priority policy ensures the low transmission delay of high priority SGUs. In addition, the emergency data transmission delay is also reduced to a significantly low level, guaranteeing the differential QoS in smart grid.
Tsurumaru, Daisuke; Miyasaka, Mitsutoshi; Nishimuta, Yusuke; Asayama, Yoshiki; Nishie, Akihiro; Honda, Hiroshi [Kyushu University, Department of Clinical Radiology, Graduate School of Medical Sciences, Fukuoka (Japan); Kawanami, Satoshi [Kyushu University, Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Fukuoka (Japan); Oki, Eiji [Kyushu University, Department of Surgery and Sciences, Graduate School of Medical Sciences, Fukuoka (Japan); Hirahashi, Minako [Kyushu University, Department of Anatomic Pathology and Pathological Sciences, Graduate School of Medical Sciences, Fukuoka (Japan)
2016-05-15
Early gastric cancer with ulceration (EGC-U) mimics advanced gastric cancer (AGC), as EGC-Us and ACGs often have similar endoscopic appearance to ulceration. The purpose of this retrospective study was to determine whether multiphasic dynamic multidetector CT (MDCT) can help differentiate EGC-Us from AGCs. Patients with EGC-Us with ulcer stages Ul-III or IV and AGCs with tumour stages T2 to T4a were enrolled. MDCT images were obtained 40 s (arterial phase), 70 s (portal phase) and 240 s (delayed phase) after injection of non-ionic contrast material. Two readers independently measured the attenuation values of the lesions by placing regions of interest. We compared the EGC-Us and AGCs using the mean attenuation values in each phase and peak enhancement phase. We analysed the diagnostic performance of CT for differentiating EGC-Us from AGCs. Forty cases (16 EGC-Us and 24 AGCs) were analysed. The mean attenuation values of the EGC-Us were significantly lower than those of the AGCs in both the arterial and portal phases (all p < 0.0001 for each reader). The peak enhancement was significantly different between the EGC-Us and AGCs for both readers (Reader 1, p = 0.0131; Reader 2, p = 0.0006). Multiphasic dynamic contrast-enhanced MDCT can help differentiate EGC-Us from AGCs. (orig.)
Symmetries of the Gas Dynamics Equations Using the Differential Form Method
Schmidt, Joe; Ramsey, Scott; Baty, Roy
2016-11-01
A brief review of the theory of exterior differential systems and isovector symmetry analysis methods is presented in the context of the one-dimensional inviscid compressible flow equations. These equations are formulated as an exterior differential system with equation of state (EOS) closure provided in terms of an adiabatic bulk modulus. The scaling symmetry generators - and corresponding EOS constraints - otherwise appearing in the existing literature are recovered through the application of and invariance under Lie derivative dragging operations.
Effect of Porosity and Cell Size on the Dynamic Compressive Properties of Aluminum Alloy Foams
无
2002-01-01
The dynamic mechanical properties of open-cell aluminum alloy foams with different relative densities and cell sizeshave been investigated by compressive tests. The strain rates varied from 700 s-1 to 2600 s-1. The experimentalresults showed that the dynamic compressive stress-strain curves exhibited a typical three-stage behavior: elastic,plateau and densification. The dynamic compressive strength of foams is affected not only by the relative densitybut also by the strain rate and cell size. Aluminum alloy foams with higher relative density or smaller cell size aremore sensitive to the strain rate than foams with lower relative density or larger cell size.
Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
Marco Antoniotti
2013-09-01
Full Text Available The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM, and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs. Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures.
Relationships between coastal processes and properties of the nearshore sea bed dynamic layer:
Rafał Ostrowski
2011-09-01
Full Text Available The paper discusses the notion of a layer of sandy sediments overlying a substratum of cohesive deposits in the coastal zone. This layer of sand is generally more mobile and is therefore conventionally referred to as the dynamic layer. Its parameters are important to coastal lithodynamic and morphodynamic processes caused by waves and currents. On the other hand, the dynamic layer is formed by nearshore hydrodynamic impact. The variability of the features of the dynamic layer on the southern Baltic dune and cliff shores in Poland is analysed on the basis of selected geological data supported by local seismo-acoustic field investigations. It appears that the conventional notion of the dynamic layer makes sense only in specific geomorphologic conditions. In such cases, mostly related to cliff shores, theoretical modelling of sediment transport should take the properties of the dynamic layer into account.
Souza, Roberto Salomon
2004-02-15
This paper presents a characterization of the physical properties of the dynamic filter of Clinac 2300 CD linear accelerator of Varian Medical Systems, installed at the Cancer National Institute (INCA), Rio de Janeiro. The 'dynamic filter factors' were measured for the 6 and 15 MV photons, in squared and rectangular fields, and compared with factors furnished at the accelerator manual and used by the planning system, IN and OUT positions, at the maximum dose depths, 5 cm, 10 cm and 29 cm, for the 6 and 15 MV photons energies. The results demonstrated that the 'dynamic filter factors' does not changes with depth and the PDP for the opened field are the same for the fields with dynamic filters. Last but not least the dynamic filters were measured and compared with the nominal angles of the accelerator and the planning system, where some discrepancies were reported.
Lattice Dynamical Properties of Ferroelectric Thin Films at the Nanoscale
Xi, Xiaoxing [Temple University
2014-01-13
In this project, we have successfully demonstrated atomic layer-by-layer growth by laser MBE from separate targets by depositing SrTiO3 films from SrO and TiO2 targets. The RHEED intensity oscillation was used to monitor and control the growth of each SrO and TiO2 layer. We have shown that by using separate oxide targets, laser MBE can achieve the same level of stoichiometry control as the reactive MBE. We have also studied strain relaxation in LaAlO3 films and its effect on the 2D electron gas at LaAlO3/SrTiO3 interface. We found that there are two layers of different in-plane lattice constants in the LaAlO3 films, one next to the SrTiO3 substrate nearly coherently strained, while the top part relaxed as the film thickness increases above 20 unit cells. This strain relaxation significantly affect the transport properties of the LaAlO3/SrTiO3 interface.
Study of dynamical properties in β-Tcp/Ch layers
Mina, A.; Caicedo, J. C. [Universidad del Valle, Tribology, Powder Metallurgy and Processing of Solid Recycled Research Group, Cali, Valle del Cauca (Colombia); Aperador, W., E-mail: jacaicedoangulo1@gmail.com [Universidad Militar Nueva Granada, Departamento de Ingenieria, 80 Entrada A La KR11 No. 101, Bogota (Colombia)
2015-07-01
β-Tricalcium phosphate/Chitosan (β-Tcp/Ch) coatings were deposited on 316l stainless steel (316l Ss) substrates by a cathodic electrodeposition technique at different coating compositions. The crystal lattice arrangements were analyzed by X-ray diffraction, and the results indicated that the crystallographic structure of β-Tcp was affected by the inclusion of the chitosan content. The changes in the surface morphology as a function of increasing chitosan in the coatings via scanning electron microscopy and atomic force microscopy showed the root-mean squares hardness of the β-Tcp/Ch coatings decreased by further increasing chitosan percentage. The elastic-plastic characteristics of the coatings were determined by conducting nano indentation test, indicating that the increase if chitosan percentage is directly related to increasing the hardness and elastic modulus of the β-Tcp/Ch coatings. Tribological characterization was performed by scratch test and pin-on-disk test to analyze the changes in the surface wear the β-Tcp/Ch coatings. Finally, the results indicated an improvement in the mechanical and tribological properties of the β-Tcp/Ch coatings as a function of increasing of the chitosan percentage. (Author)
Dynamic properties of small-scale solar wind plasma fluctuations.
Riazantseva, M O; Budaev, V P; Zelenyi, L M; Zastenker, G N; Pavlos, G P; Safrankova, J; Nemecek, Z; Prech, L; Nemec, F
2015-05-13
The paper presents the latest results of the studies of small-scale fluctuations in a turbulent flow of solar wind (SW) using measurements with extremely high temporal resolution (up to 0.03 s) of the bright monitor of SW (BMSW) plasma spectrometer operating on astrophysical SPECTR-R spacecraft at distances up to 350,000 km from the Earth. The spectra of SW ion flux fluctuations in the range of scales between 0.03 and 100 s are systematically analysed. The difference of slopes in low- and high-frequency parts of spectra and the frequency of the break point between these two characteristic slopes was analysed for different conditions in the SW. The statistical properties of the SW ion flux fluctuations were thoroughly analysed on scales less than 10 s. A high level of intermittency is demonstrated. The extended self-similarity of SW ion flux turbulent flow is constantly observed. The approximation of non-Gaussian probability distribution function of ion flux fluctuations by the Tsallis statistics shows the non-extensive character of SW fluctuations. Statistical characteristics of ion flux fluctuations are compared with the predictions of a log-Poisson model. The log-Poisson parametrization of the structure function scaling has shown that well-defined filament-like plasma structures are, as a rule, observed in the turbulent SW flows.
Zhidkov, E P
2000-01-01
We consider a nonlinear integro-differential equation on a segment with zero Dirichlet boundary conditions and a normalization condition, containing a spectral parameter, which can arise in the mean field approximation for a quantum-mechanical description of a solid. We prove the existence of a countable set of solutions and investigate properties of these solutions. The main result consists in proving the property of being a Bary basis for a sequence of solutions of the problem, possessing a given behavior, the existence of which is proved.
Zhang, Liuyang; Wang, Xianqiao
2014-08-12
Single-walled carbon nanotubes (SWCNTs) have demonstrated a remarkable capacity for self-assembly into nanobundles through intermolecular van der Waals interactions, bestowing these agglomerates extraordinary mechanical, thermal, and electrical properties. However, how to improve the binding ability of SWCNT bundles to mitigate the delamination and sliding effects between individual nanotubes remains to be further investigated. By utilizing molecular dynamics simulation, here we present the construction of SWCNT bundles with discrete cylindrical and continuous helical binders by noncovalent coating of the bundle surface with sp(2)-hybridized carbon networks. Meanwhile, by modifying the binding potentials between the binder and SWCNT bundles to mimic the different binding types actually used, the bound SWCNT bundle presents a variety of distinct mechanical properties unmatched by unbound bundles. The pull-out tests with discrete binders portray an intriguing force-displacement curve which can help determine the number of discrete binders used in the system. SWCNT bundles with binders depict unique mechanical properties which can differentiate them from unbound SWCNT bundles. These findings provide compelling evidence that bound SWCNT bundles will open up novel avenues for a variety of applications, especially in nanocomposites.
Kapilevich, Leonid V.; Zakharova, Anna N.; Kabachkova, Anastasia V.; Kironenko, Tatyana A.; Orlov, Sergei N.
2017-01-01
Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training interventions on cytokine production remains poorly defined. In this study, we compared effects of dynamic and static load on cytokine plasma content in elite strength- and endurance-trained athletes vs. healthy untrained volunteers. The plasma cytokine content was measured before, immediately after, and 30 min post-exercise using enzyme-linked immunosorbent assay. Pedaling on a bicycle ergometer increased IL-6 and IL-8 content in the plasma of trained athletes by about 4- and 2-fold, respectively. In contrast to dynamic load, weightlifting had negligible impact on these parameters in strength exercise-trained athletes. Unlike IL-6 and IL-8, dynamic exercise had no impact on IL-15 and LIF, whereas static load increases the content of these cytokines by ~50%. Two-fold increment of IL-8 content seen in athletes subjected to dynamic exercise was absent in untrained individuals, whereas the ~50% increase in IL-15 triggered by static load in the plasma of weightlifting athletes was not registered in the control group. Thus, our results show the distinct impact of static and dynamic exercises on cytokine content in the plasma of trained athletes. They also demonstrate that both types of exercises differentially affect cytokine content in plasma of athletes and untrained persons.
Kapilevich, Leonid V; Zakharova, Anna N; Kabachkova, Anastasia V; Kironenko, Tatyana A; Orlov, Sergei N
2017-01-01
Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training interventions on cytokine production remains poorly defined. In this study, we compared effects of dynamic and static load on cytokine plasma content in elite strength- and endurance-trained athletes vs. healthy untrained volunteers. The plasma cytokine content was measured before, immediately after, and 30 min post-exercise using enzyme-linked immunosorbent assay. Pedaling on a bicycle ergometer increased IL-6 and IL-8 content in the plasma of trained athletes by about 4- and 2-fold, respectively. In contrast to dynamic load, weightlifting had negligible impact on these parameters in strength exercise-trained athletes. Unlike IL-6 and IL-8, dynamic exercise had no impact on IL-15 and LIF, whereas static load increases the content of these cytokines by ~50%. Two-fold increment of IL-8 content seen in athletes subjected to dynamic exercise was absent in untrained individuals, whereas the ~50% increase in IL-15 triggered by static load in the plasma of weightlifting athletes was not registered in the control group. Thus, our results show the distinct impact of static and dynamic exercises on cytokine content in the plasma of trained athletes. They also demonstrate that both types of exercises differentially affect cytokine content in plasma of athletes and untrained persons.
Raghavendra Baregundi Subbarao
2015-05-01
Full Text Available Endometrial stromal cells (EMSCs obtained from porcine uterus (n = 6 were positive for mesenchymal stem cell markers (CD29, CD44 and CD90, and negative for epithelial marker CD9 and hematopoietic markers CD34, CD45 analyzed by flow cytometry. Further the cells were positive for expression of mesenchymal markers, CD105, CD140b, and CD144 by PCR. Pluripotent markers OCT4, SOX2, and NANOG were positively expressed in EMSCs analyzed by Western blotting and PCR. Further, differentiation into adipocytes and osteocytes was confirmed by cytochemical staining and lineage specific gene expression by quantitative realtime-PCR. Adipocyte (FABP, LPL, AP2 and osteocyte specific genes (ON, BG, RUNX2 in differentiated EMSCs showed significant (p < 0.05 increase in expression compared to undifferentiated control cells. Neurogenic transdifferentiation of EMSCs exhibited distinctive dendritic morphology with axon projections and neuronal specific genes, NFM, NGF, MBP, NES, B3T and MAP2 and proteins, B3T, NFM, NGF, and TRKA were positively expressed in neuronal differentiated cells. Functional analysis of neuronal differentiated EMSCs displayed voltage-dependence and kinetics for transient outward K+ currents (Ito, at holding potential of −80 mV, Na+ currents and during current clamp, neuronal differentiated EMSCs was more negative than that of control EMSCs. Porcine EMSCs is a suitable model for studying molecular mechanism of transdifferentiation, assessment of electrophysiological properties and their efficiency during in vivo transplantation.
Larsen, Anne Vibeke Andrée; Simonsen, Helle J; Law, Ian
2013-01-01
INTRODUCTION: To investigate if perfusion measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to differentiate radiation necrosis from tumor recurrence in patients with high-grade glioma. METHODS: The study was approved by the institutional review board...... and informed consent was obtained from all subjects. 19 patients were recruited following surgery and radiation therapy for glioma. Patients had contrast enhancing lesions, which during the standard MRI examination could not be exclusively determined as recurrence or radiation necrosis. DCE-MRI was used......-MRI may predict the status of contrast enhancing lesions and give results very similar to FDG-PET with regards to differentiation between tumor recurrence and radiation necrosis....
无
2010-01-01
We give an equivalent construction of the infinitesimal time translation operator for partial differential evolution equation in the algebraic dynamics algorithm proposed by Shun-Jin Wang and his students. Our construction involves only simple partial differentials and avoids the derivative terms of δ function which appear in the course of computation by means of Wang-Zhang operator. We prove Wang’s equivalent theorem which says that our construction and Wang-Zhang’s are equivalent. We use our construction to deal with several typical equations such as nonlinear advection equation, Burgers equation, nonlinear Schrodinger equation, KdV equation and sine-Gordon equation, and obtain at least second order approximate solutions to them. These equations include the cases of real and complex field variables and the cases of the first and the second order time derivatives.
Liu, Chengshi
2010-08-01
We give an equivalent construction of the infinitesimal time translation operator for partial differential evolution equation in the algebraic dynamics algorithm proposed by Shun-Jin Wang and his students. Our construction involves only simple partial differentials and avoids the derivative terms of δ function which appear in the course of computation by means of Wang-Zhang operator. We prove Wang’s equivalent theorem which says that our construction and Wang-Zhang’s are equivalent. We use our construction to deal with several typical equations such as nonlinear advection equation, Burgers equation, nonlinear Schrodinger equation, KdV equation and sine-Gordon equation, and obtain at least second order approximate solutions to them. These equations include the cases of real and complex field variables and the cases of the first and the second order time derivatives.
Wu, A M; Song, S C; Sugii, S; Herp, A
1997-01-01
Differentiating the binding properties of applied lectins should facilitate the selection of lectins for characterization of glycoreceptors on the cell surface. Based on the binding specificities studied by inhibition assays of lectin-glycan interactions, over twenty Gal and/or GalNAc specific lectins have been divided into eight groups according to their specificity for structural units (lectin determinants), which are the disaccharide as all or part of the determinants and of GalNAc alpha 1-->Ser (Thr) of the peptide chain. A scheme of codes for lectin determinants is illustrated as follows: (1) F (GalNAc alpha 1-->3GalNAc), Forssman specific disaccharide--Dolichos biflorus (DBL), Helix pomatia (HPL) and Wistaria floribunda (WFL) lectins. (2) A (GalNAc alpha 1-->3 Gal), blood group A specific disaccharide--Codium fragile subspecies tomentosoides (CFT), Soy bean (SBL), Vicia villosa-A4 (VVL-A4), and Wistaria floribunda (WFL) lectins. (3) Tn (GalNAc alpha 1-->Ser (Thr) of the protein core)--Vicia villosa B4 (VVL-B4), Salvia sclarea (SSL), Maclura pomifera (MPL), Bauhinia purpurea alba (BPL) and Artocarpus integrifolia (Jacalin, AIL). (4) T (Gal beta 1-->3GalNAc), the mucin type sugar sequences on the human erythrocyte membrane(T alpha), T antigen or the disaccharides at the terminal nonreducing end of gangliosides (T beta)--Peanut (PNA), Bauhinia purpurea alba (BPL), Maclura pomifera (MPL), Sophora japonica (SJL), Artocarpus lakoocha (Artocarpin) lectins and Abrus precatorius agglutinin (APA).(5) I and II (Gal beta 1-->3(4)GlcNAc)--the disaccharide residue at the nonreducing end of the carbohydrate chains derived from either N- or O-glycosidic linkage--Ricinus communis agglutinin (RCA1), Datura stramonium (TAL, Thorn apple), Erythrina cristagalli (ECL, Coral tree), and Geodia cydonium (GCL). (6) B (Gal alpha 1-->3Gal), human blood group B specific disaccharide--Griffonia(Banderiaea) simplicifolia B4 (GSI-B4). (7) E (Gal alpha 1-->4Gal), receptors for pathogenic E
Li, Fangting
2017-01-01
The notion of an attractor has been widely employed in thinking about the nonlinear dynamics of organisms and biological phenomena as systems and as processes. The notion of a landscape with valleys and mountains encoding multiple attractors, however, has a rigorous foundation only for closed, thermodynamically non-driven, chemical systems, such as a protein. Recent advances in the theory of nonlinear stochastic dynamical systems and its applications to mesoscopic reaction networks, one reaction at a time, have provided a new basis for a landscape of open, driven biochemical reaction systems under sustained chemostat. The theory is equally applicable not only to intracellular dynamics of biochemical regulatory networks within an individual cell but also to tissue dynamics of heterogeneous interacting cell populations. The landscape for an individual cell, applicable to a population of isogenic non-interacting cells under the same environmental conditions, is defined on the counting space of intracellular chemical compositions x = (x1,x2, … ,xN) in a cell, where xℓ is the concentration of the ℓth biochemical species. Equivalently, for heterogeneous cell population dynamics xℓ is the number density of cells of the ℓth cell type. One of the insights derived from the landscape perspective is that the life history of an individual organism, which occurs on the hillsides of a landscape, is nearly deterministic and ‘programmed’, while population-wise an asynchronous non-equilibrium steady state resides mostly in the lowlands of the landscape. We argue that a dynamic ‘blue-sky’ bifurcation, as a representation of Waddington's landscape, is a more robust mechanism for a cell fate decision and subsequent differentiation than the widely pictured pitch-fork bifurcation. We revisit, in terms of the chemostatic driving forces upon active, living matter, the notions of near-equilibrium thermodynamic branches versus far-from-equilibrium states. The emergent
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
Federico Ferro
Full Text Available Although the role played by the core transcription factor network, which includes c-Myc, Klf4, Nanog, and Oct4, in the maintenance of embryonic stem cell (ES pluripotency and in the reprogramming of adult cells is well established, its persistence and function in adult stem cells are still debated. To verify its persistence and clarify the role played by these molecules in adult stem cell function, we investigated the expression pattern of embryonic and adult stem cell markers in undifferentiated and fully differentiated dental pulp stem cells (DPSC. A particular attention was devoted to the expression pattern and intracellular localization of the stemness-associated isoform A of Oct4 (Oct4A. Our data demonstrate that: Oct4, Nanog, Klf4 and c-Myc are expressed in adult stem cells and, with the exception of c-Myc, they are significantly down-regulated following differentiation. Cell differentiation was also associated with a significant reduction in the fraction of DPSC expressing the stem cell markers CD10, CD29 and CD117. Moreover, a nuclear to cytoplasm shuttling of Oct4A was identified in differentiated cells, which was associated with Oct4A phosphorylation. The present study would highlight the importance of the post-translational modifications in DPSC stemness maintenance, by which stem cells balance self-renewal versus differentiation. Understanding and controlling these mechanisms may be of great importance for stemness maintenance and stem cells clinical use, as well as for cancer research.
Understanding mechanical properties of polymer nanocomposites with molecular dynamics simulations
Sen, Suchira
Equilibrium Molecular Dynamics (MD) simulations are used extensively to study various aspects of polymer nanocomposite (PNC) behavior in the melt state---the key focus is on understanding mechanisms of mechanical reinforcement. Mechanical reinforcement of the nanocomposite is believed to be caused by the formation of a network-like structure---a result of polymer chains bridging particles to introduce network elasticity. In contrast, in traditional composites, where the particle size range is hundreds of microns and high loadings of particle are used, the dominant mechanism is the formation of a percolated filler structure. The difference in mechanism with varying particle sizes, at similar particle loading, arises from the polymer-particle interfacial area available, which increases dramatically as the particle size decreases. Our interest in this work is to find (a) the kind of polymer-particle interactions necessary to facilitate the formation of a polymer network in a nanocomposite, and (b) the reinforcing characteristics of such a polymer network. We find that very strong polymer-particle binding is necessary to create a reinforcing network. The strength of the binding has to be enough to immobilize polymer on the particle surface for timescales comparable and larger than the terminal relaxation time of the stress of the neat melt. The second finding, which is a direct outcome of very strong binding, is that the method of preparation plays a critical role in determining the reinforcement of the final product. The starting conformations of the polymer chains determine the quality of the network. The strong binding traps the polymer on the particle surface which gets rearranged to a limited extent, within stress relaxation times. Significant aging effects are seen in system relaxation; the inherent non-equilibrium consequences of such strong binding. The effect of the polymer immobilization slows down other relaxation processes. The diffusivity of all chains is
Probing the dynamic differential stiffness of dsDNA interacting with RecA in the enthalpic regime.
Lien, Chia-Hui; Wei, Ming-Tzo; Tseng, Te-Yu; Lee, Chien-Der; Wang, Chung; Wang, Ting-Fang; Ou-Yang, H Daniel; Chiou, Arthur
2009-10-26
RecA plays a central role in homologous recombination of DNA. When RecA combines with dsDNA to form RecA-dsDNA nucleofilament, it unwinds dsDNA and changes its structure. The unwinding length extension of a DNA segment interacting with RecA has been studied by various techniques, but the dynamic differential stiffness of dsDNA conjugating with RecA has not been well characterized. We applied oscillatory optical tweezers to measure the differential stiffness of dsDNA molecules, interacting with RecA, as a function of time at a constant stretching force of 33.6pN. The values of the differential stiffness of DNA (for stretching force in the range of 20.0pN to 33.6pN) measured by oscillatory optical tweezers, both before and after its interaction with RecA, are consistent with those measured by stationary optical tweezers. In the dynamic measurement, we have shown that the association (or binding) rate increases with higher concentration of RecA; besides, we have also monitored in real-time the dissociation of RecA from the stretched RecA-dsDNA filament as ATPgammaS was washed off from the sample chamber. Finally, we verified that RecA (I26C), a form of RecA mutant, does not affect the differential stiffness of the stretched DNA sample. It implies that mutant RecA (I26C) does not bind to the DNA, which is consistent with the result obtained by conventional biochemical approach.
Transport properties of room temperature ionic liquids from classical molecular dynamics
Andreussi, Oliviero
2012-01-01
Room Temperature Ionic Liquids (RTILs) have attracted much of the attention of the scientific community in the past decade due the their novel and highly customizable properties. Nonetheless their high viscosities pose serious limitations to the use of RTILs in practical applications. To elucidate some of the physical aspects behind transport properties of RTILs, extensive classical molecular dynamics (MD) calculations are reported. Bulk viscosities and ionic conductivities of butyl-methyl-imidazole based RTILs are presented over a wide range of temperatures. The dependence of the properties of the liquids on simulation parameters, e.g. system size effects and choice of the interaction potential, is analyzed.
Resolving Dynamic Properties of Polymers through Coarse-Grained Computational Studies
Salerno, K. Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Agrawal, Anupriya [Washington Univ., St. Louis, MO (United States). Dept. of Mechanical Engineering and Materials Science; Clemson Univ., SC (United States). Dept. of Chemistry; Perahia, Dvora [Clemson Univ., SC (United States). Dept. of Chemistry; Grest, Gary S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2016-02-05
Coupled length and time scales determine the dynamic behavior of polymers and underlie their unique viscoelastic properties. To resolve the long-time dynamics it is imperative to determine which time and length scales must be correctly modeled. In this paper, we probe the degree of coarse graining required to simultaneously retain significant atomistic details and access large length and time scales. The degree of coarse graining in turn sets the minimum length scale instrumental in defining polymer properties and dynamics. Using linear polyethylene as a model system, we probe how the coarse-graining scale affects the measured dynamics. Iterative Boltzmann inversion is used to derive coarse-grained potentials with 2–6 methylene groups per coarse-grained bead from a fully atomistic melt simulation. We show that atomistic detail is critical to capturing large-scale dynamics. Finally, using these models we simulate polyethylene melts for times over 500 μs to study the viscoelastic properties of well-entangled polymer melts.
The simplified Hubbard model in one and two dimensions. Thermodynamic and dynamic properties
Vries, Pedro de; Michielsen, Kristel; Raedt, Hans De
1993-01-01
Thermodynamic and dynamic properties of the one and two-dimensional simplified Hubbard model are studied. At zero temperature and half filling, no metal-insulator transition occurs for nonzero coupling U and the system is an antiferromagnetic insulator. The behavior of the gap in the single-particle
THE SIMPLIFIED HUBBARD-MODEL IN ONE AND 2 DIMENSIONS - THERMODYNAMIC AND DYNAMIC PROPERTIES
DEVRIES, P; MICHIELSEN, K; DERAEDT, H
1993-01-01
Thermodynamic and dynamic properties of the one and two-dimensional simplified Hubbard model are studied. At zero temperature and half filling, no metal-insulator transition occurs for nonzero coupling U and the system is an antiferromagnetic insulator. The behavior of the gap in the single-particle
Elastic properties of surfactant monolayers at liquid-liquid interfaces: A molecular dynamics study
Laradji, Mohamed; Mouritsen, Ole G.
2000-01-01
Using a simple molecular model based on the Lennard-Jones potential, we systematically study the elastic properties of liquid-liquid interfaces containing surfactant molecules by means of extensive and large-scale molecular dynamics simulations. The main elastic constants of the interface, corres...
Microstructure and Dynamic Failure Properties of Freeze-Cast Materials for Thermobaric Warhead Cases
2012-12-01
LIST OF FIGURES Figure 1. Freeze cast process: slurry preparation, solidification, sublimation and sintering (From Ref 6...the process can be divided into four steps, illustrated in Figure 1. 6 Figure 1. Freeze cast process: slurry preparation, solidification...DYNAMIC FAILURE PROPERTIES OF FREEZE- CAST MATERIALS FOR THERMOBARIC WARHEAD CASES by Yi Ming Tan December 2012 Thesis Advisor: Joseph
Kinch, K.M.; Merrison, J.P.; Gunnlaugsson, H.P.;
2006-01-01
Motivated by questions raised by the magnetic properties experiments on the NASA Mars Pathfinder and Mars Exploration Rover (MER) missions, we have studied in detail the capture of airborne magnetic dust by permanent magnets using a computational fluid dynamics (CFD) model supported by laboratory...
Maloberti, Olivier [LEG-INPG/UJF-CNRS UMR 5529: BP 46, 38402 Saint Martin d' Heres cedex (France) and Schneider Electric Corporate Research and Developments, 37 quai Paul Louis Merlin, 38050 Grenoble cedex 9 (France)]. E-mail: olivier.maloberti@schneider-electric.com; Kedous-Lebouc, A. [LEG-INPG/UJF-CNRS UMR 5529: BP 46, 38402 Saint Martin d' Heres cedex (France); Geoffroy, O. [LLN-UJF/INPG-CNRS UPR 5051: 25 avenue des Martyrs, 38050 Grenoble cedex 9 (France); Meunier, G. [LEG-INPG/UJF-CNRS UMR 5529: BP 46, 38402 Saint Martin d' Heres cedex (France); Mazauric, V. [Schneider Electric Corporate Research and Developments, 37 quai Paul Louis Merlin, 38050 Grenoble cedex 9 (France)
2006-09-15
So as to fuse dynamic magnetization properties of soft materials with the electromagnetism theory, we investigate the inclusion of microscopic reversal processes related to domains and walls in macroscopic Maxwell equations. We first introduce a model for independent walls and the unidirectional motion mechanism; then we characterize one sample with measurements and analytical calculations in case of one-dimensional linear problems.
Global and local properties used as analyses tools for molecular-dynamics simulations
Bachlechner, Martina E.; Anderson, Jonas T.; Cao, Deng; Leonard, Robert H.; Owens, Eli T.; Schiffbauer, Jarrod E.; Burky, Melissa R.; Ducatman, Samuel C.; Guffey, Eric J.; Serrano Ramos2, Fernando
2006-03-01
Molecular dynamics simulations have been used to study mechanical failure in realistic interface materials. Averaging over the individual atoms' contributions yields local and global information including displacements, bond angles, strains, stress tensor components, and pair distribution functions. A combined analysis of global and local properties facilitates detailed insight in the mechanisms of failure, which will eventually guide on how to prevent failure of interfaces.
Dynamic dielectric properties of a wood liquefaction system using polyethylene glycol and glycerol
Mengchao Zhou; Thomas L. Eberhardt; Bo Cai; Chung-Yun Hse; Hui Pan
2017-01-01
Microwave-assisted liquefaction has shown potential for rapid thermal processing of lignocellulosic biomass. The efficiency of microwave heating depends largely on the dielectric properties of the materials being heated. The objective of this study was to investigate the dynamic interactions between microwave energy and the reaction system during the liquefaction of a...
Pakkanen, Kirsi I.; Duelund, Lars; Qvortrup, Klaus
2011-01-01
We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100µm and with the help of these are e.g. able to squeeze through narrow passages ...
Pakkanen, Kirsi I.; Duelund, Lars; Qvortrup, Klaus
2011-01-01
We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100µm and with the help of these are e.g. able to squeeze through narrow passages ...
PROPERTIES OF PROLIFERATION AND DIFFERENTIATION OF NEONATAL RAT RETINAL PROGENITOR CELLS IN VITRO
无
2006-01-01
Neural stem or progenitor cells are i mmature,multipotent cells that have the capacityto differenti-ate into the three CNSlineages(neurons,astrocytesand oligodendrocytes)[1].Neuronal degeneration isthe cause of visual i mpair ment associated with prev-alent ocular diseases such as retinitis pigmentosa,age-related macular degeneration,retinal detach-ment and glaucoma[2].Transplantation of culturedneural stemcells/progenitors may helprestore visionby repopulating the damaged retina and replacingthe degenerati...
Omran, Hesham
2016-10-06
We propose a successive-approximation capacitive sensor readout circuit that achieves 35fJ/Step energy efficiency FoM, which represents 4× improvement over the state-of-the-art. A fully differential architecture is employed to provide robustness against common mode noise and errors. An inverter-based amplifier with near-threshold biasing provides robust, fast, and energy-efficient operation. Quasi-dynamic operation is used to maintain the energy efficiency for a scalable sample rate. A hybrid coarse-fine capacitive DAC achieves 11.7bit effective resolution in a compact area. © 2016 IEEE.
Compression-based investigation of the dynamical properties of cellular automata and other systems
Zenil, Hector
2009-01-01
A method for studying the qualitative dynamical properties of abstract computing machines based on the approximation of their program-size complexity using a general lossless compression algorithm is presented. It is shown that the compression-based approach classifies cellular automata (CA) into clusters according to their heuristic behavior, with these clusters showing a correspondence with Wolfram's main classes of CA behavior. A compression based method to estimate a characteristic exponent to detect phase transitions and measure the resiliency or sensitivity of a system to its initial conditions is also proposed, constituting a compression-based framework for investigating the dynamical properties of cellular automata and other systems. Keywords: cellular automata classification, Wolfram's four classes, phase transition detection, program-size complexity, compression-based clustering, non-linear dynamics, Lyapunov characteristic exponents.
Grauer, Jared A.; Morelli, Eugene A.
2013-01-01
The NASA Generic Transport Model (GTM) nonlinear simulation was used to investigate the effects of errors in sensor measurements, mass properties, and aircraft geometry on the accuracy of identified parameters in mathematical models describing the flight dynamics and determined from flight data. Measurements from a typical flight condition and system identification maneuver were systematically and progressively deteriorated by introducing noise, resolution errors, and bias errors. The data were then used to estimate nondimensional stability and control derivatives within a Monte Carlo simulation. Based on these results, recommendations are provided for maximum allowable errors in sensor measurements, mass properties, and aircraft geometry to achieve desired levels of dynamic modeling accuracy. Results using additional flight conditions and parameter estimation methods, as well as a nonlinear flight simulation of the General Dynamics F-16 aircraft, were compared with these recommendations