WorldWideScience

Sample records for differential global positioning

  1. Report to Congress : recapitalization plan for the nationwide differential global positioning system (NDGPS).

    Science.gov (United States)

    2010-06-01

    The U.S. Department of Transportation (DOT) has developed a recpitlaization plan to reduce technical, cost, and programmatic risks of the DOT-funded inland segment of the Nationwide Differential Global Positioning System (NDGPS)

  2. Possible application of differential global positioning system (DGPS ...

    African Journals Online (AJOL)

    hope&shola

    2010-11-29

    Nov 29, 2010 ... for the sub-alpine vineyards by Bertamini et al. (1999),. Murisier et al. (2003) and Rusjan (2002), the significant influence of increasing altitude on the sugar content of grapes was detected due to the increasing hours of day sunshine on well exposed south- and west-facing sub- parcels. However, positive ...

  3. Differential Global Positioning System (DGPS) for Flight Testing (Global Positioning System Differentiel (DGPS) pour les Essais en vol)

    Science.gov (United States)

    2008-10-01

    Pseudorange P-DME Precise Distance Measurement Equipment PDOP Position Dilution of Precision PISQ Poligono Sperimentale Interforze del Salto di...1553, USB , etc. The system should be able to conform to the RTCM-SC-104 standard protocol for differential corrections. The antenna can be either...Figure 4-2. This is a micro - strip antenna that can be mounted on a precisely adjustable platform and protected with an impermeable cover. DGPS

  4. Integration of differential global positioning system with ultrawideband synthetic aperture radar for forward imaging

    Science.gov (United States)

    Wong, David C.; Bui, Khang; Nguyen, Lam H.; Smith, Gregory; Ton, Tuan T.

    2003-09-01

    The U.S. Army Research Laboratory (ARL), as part of a customer and mission-funded exploratory development program, has been evaluating low-frequency, ultra-wideband (UWB) imaging radar for forward imaging to support the Army's vision for increased mobility and survivability of unmanned ground vehicle missions. As part of the program to improve the radar system and imaging capability, ARL has incorporated a differential global positioning system (DGPS) for motion compensation into the radar system. The use of DGPS can greatly increase positional accuracy, thereby allowing us to improve our ability to focus better images for the detection of small targets such as plastic mines and other concealed objects buried underground. The ability of UWB radar technology to detect concealed objects could provide an important obstacle avoidance capability for robotic vehicles, which would improve the speed and maneuverability of these vehicles and consequently increase the survivability of the U.S. forces. This paper details the integration and discusses the significance of integrating a DGPS into the radar system for forward imaging. It also compares the difference between DGPS and the motion compensation data collected by the use of the original theodolite-based system.

  5. Multi-Unmanned Aerial Vehicle (UAV) Cooperative Fault Detection Employing Differential Global Positioning (DGPS), Inertial and Vision Sensors

    Science.gov (United States)

    Heredia, Guillermo; Caballero, Fernando; Maza, Iván; Merino, Luis; Viguria, Antidio; Ollero, Aníbal

    2009-01-01

    This paper presents a method to increase the reliability of Unmanned Aerial Vehicle (UAV) sensor Fault Detection and Identification (FDI) in a multi-UAV context. Differential Global Positioning System (DGPS) and inertial sensors are used for sensor FDI in each UAV. The method uses additional position estimations that augment individual UAV FDI system. These additional estimations are obtained using images from the same planar scene taken from two different UAVs. Since accuracy and noise level of the estimation depends on several factors, dynamic replanning of the multi-UAV team can be used to obtain a better estimation in case of faults caused by slow growing errors of absolute position estimation that cannot be detected by using local FDI in the UAVs. Experimental results with data from two real UAVs are also presented. PMID:22400008

  6. Multi-Unmanned Aerial Vehicle (UAV) Cooperative Fault Detection Employing Differential Global Positioning (DGPS), Inertial and Vision Sensors.

    Science.gov (United States)

    Heredia, Guillermo; Caballero, Fernando; Maza, Iván; Merino, Luis; Viguria, Antidio; Ollero, Aníbal

    2009-01-01

    This paper presents a method to increase the reliability of Unmanned Aerial Vehicle (UAV) sensor Fault Detection and Identification (FDI) in a multi-UAV context. Differential Global Positioning System (DGPS) and inertial sensors are used for sensor FDI in each UAV. The method uses additional position estimations that augment individual UAV FDI system. These additional estimations are obtained using images from the same planar scene taken from two different UAVs. Since accuracy and noise level of the estimation depends on several factors, dynamic replanning of the multi-UAV team can be used to obtain a better estimation in case of faults caused by slow growing errors of absolute position estimation that cannot be detected by using local FDI in the UAVs. Experimental results with data from two real UAVs are also presented.

  7. Ground-penetrating radar and differential global positioning system data collected from Long Beach Island, New Jersey, April 2015

    Science.gov (United States)

    Zaremba, Nicholas J.; Smith, Kathryn E.L.; Bishop, James M.; Smith, Christopher G.

    2016-08-04

    Scientists from the United States Geological Survey, St. Petersburg Coastal and Marine Science Center, U.S. Geological Survey Pacific Coastal and Marine Science Center, and students from the University of Hawaii at Manoa collected sediment cores, sediment surface grab samples, ground-penetrating radar (GPR) and Differential Global Positioning System (DGPS) data from within the Edwin B. Forsythe National Wildlife Refuge–Holgate Unit located on the southern end of Long Beach Island, New Jersey, in April 2015 (FAN 2015-611-FA). The study’s objective was to identify washover deposits in the stratigraphic record to aid in understanding barrier island evolution. This report is an archive of GPR and DGPS data collected from Long Beach Island in 2015. Data products, including raw GPR and processed DGPS data, elevation corrected GPR profiles, and accompanying Federal Geographic Data Committee metadata can be downloaded from the Data Downloads page.

  8. Ground penetrating radar and differential global positioning system data collected in April 2016 from Fire Island, New York

    Science.gov (United States)

    Forde, Arnell S.; Bernier, Julie C.; Miselis, Jennifer L.

    2018-02-22

    Researchers from the U.S. Geological Survey (USGS) conducted a long-term coastal morphologic-change study at Fire Island, New York, prior to and after Hurricane Sandy impacted the area in October 2012. The Fire Island Coastal Change project objectives include understanding the morphologic evolution of the barrier island system on a variety of time scales (months to centuries) and resolving storm-related impacts, post-storm beach response, and recovery. In April 2016, scientists from the USGS St. Petersburg Coastal and Marine Science Center conducted geophysical and sediment sampling surveys on Fire Island to characterize and quantify spatial variability in the subaerial geology with the goal of subsequently integrating onshore geology with other surf zone and nearshore datasets.  This report, along with the associated USGS data release, serves as an archive of ground penetrating radar (GPR) and post-processed differential global positioning system (DGPS) data collected from beach and back-barrier environments on Fire Island, April 6–13, 2016 (USGS Field Activity Number 2016-322-FA). Data products, including unprocessed GPR trace data, processed DGPS data, elevation-corrected subsurface profile images, geographic information system files, and accompanying Federal Geographic Data Committee metadata are available for download.

  9. Raw and processed ground-penetrating radar and postprocessed differential global positioning system data collected from Assateague Island, Maryland, October 2014

    Science.gov (United States)

    Zaremba, Nicholas J.; Bernier, Julie C.; Forde, Arnell S.; Smith, Christopher G.

    2016-06-08

    Scientists from the U.S. Geological Survey, St. Petersburg Coastal and Marine Science Center acquired sediment cores, sediment surface grab samples, ground-penetrating radar (GPR) and Differential Global Positioning System (DGPS) data from Assateague Island, Maryland, in October 2014. The objectives were to identify washover deposits in the stratigraphic record to aid in understanding barrier island evolution.

  10. A study of the application of differential techniques to the global positioning system for a helicopter precision approach

    Science.gov (United States)

    Mccall, D. L.

    1984-01-01

    The results of a simulation study to define the functional characteristics of a airborne and ground reference GPS receiver for use in a Differential GPS system are doumented. The operations of a variety of receiver types (sequential-single channel, continuous multi-channel, etc.) are evaluated for a typical civil helicopter mission scenario. The math model of each receiver type incorporated representative system errors including intentional degradation. The results include the discussion of the receiver relative performance, the spatial correlative properties of individual range error sources, and the navigation algorithm used to smooth the position data.

  11. The Global Positioning System

    Science.gov (United States)

    ,

    1999-01-01

    The Global Positioning System (GPS) is a constellation of navigation satellites called Navigation Satellite Timing And Ranging (NAVSTAR), maintained by the U.S. Department of Defense. Many outdoor enthusiasts recognize that a handheld GPS receiver can be an accurate tool for determining their location on the terrain. The GPS receiver helps determine locations on the Earth's surface by collecting signals from three or more satellites through a process called triangulation. Identifying a location on the Earth is more useful if you also know about the surrounding topographic conditions. Using a topographic map with the GPS receiver provides important information about features of the surrounding terrain and can help you plot an effective route from one location to another.

  12. Global Positioning System Bibliography

    Science.gov (United States)

    1992-03-01

    316. Buisson, J. A., 0. J. Oaks, and H. Warren (1985). "Absolute calibration and precise positioning between major European time observatories and...Fla, 29 November-2 December, pp. 39-46. Krakiwsky, E. J., B. Wanless, B. Buffett , K. P. Schwarz, and M. Nakiboglu (1985). "GPS orbit improvement and...K. P. Schwarz, E. J. Krakiwsky, B. Buffett , and B. Wanless (1984). "A multi-pass, multi-station approach to GPS orbital improvement and precise

  13. Algorithms for Global Positioning

    DEFF Research Database (Denmark)

    Borre, Kai; Strang, Gilbert

    and replaces the authors' previous work, Linear Algebra, Geodesy, and GPS (1997). An initial discussion of the basic concepts, characteristics and technical aspects of different satellite systems is followed by the necessary mathematical content which is presented in a detailed and self-contained fashion......The emergence of satellite technology has changed the lives of millions of people. In particular, GPS has brought an unprecedented level of accuracy to the field of geodesy. This text is a guide to the algorithms and mathematical principles that account for the success of GPS technology....... At the heart of the matter are the positioning algorithms on which GPS technology relies, the discussion of which will affirm the mathematical contents of the previous chapters. Numerous ready-to-use MATLAB codes are included for the reader. This comprehensive guide will be invaluable for engineers...

  14. Global affine differential geometry of hypersurfaces

    CERN Document Server

    Li, An-Min; Zhao, Guosong; Hu, Zejun

    2015-01-01

    This book draws a colorful and widespread picture of global affine hypersurface theory up to the most recent state. Moreover, the recent development revealed that affine differential geometry- as differential geometry in general- has an exciting intersection area with other fields of interest, like partial differential equations, global analysis, convex geometry and Riemann surfaces.

  15. Global Positioning System Standard Positioning Service Performance Standard

    Science.gov (United States)

    2008-09-01

    The U.S. Global Positioning System (GPS) Standard Positioning Service (SPS) consists of space-based positioning, navigation, and timing (PNT) signals delivered free of direct user fees for peaceful civil, commercial, and scientific uses worldwide. Th...

  16. Differentiation of 13 positive emotions by appraisals.

    Science.gov (United States)

    Tong, Eddie M W

    2015-01-01

    This research examined how strongly appraisals can differentiate positive emotions and how they differentiate positive emotions. Thirteen positive emotions were examined, namely, amusement, awe, challenge, compassion, contentment, gratitude, hope, interest, joy, pride, relief, romantic love and serenity. Participants from Singapore and the USA recalled an experience of each emotion and thereafter rated their appraisals of the experience. In general, the appraisals accurately classified the positive emotions at rates above chance levels, and the appraisal-emotion relationships conformed to predictions. Also, the appraisals were largely judged by participants as relevant to their positive emotion experiences, and the appraisal-emotion relationships were largely consistent across the two countries.

  17. An approach to regional wetland digital elevation model development using a differential global positioning system and a custom-built helicopter-based surveying system

    Science.gov (United States)

    Jones, J.W.; Desmond, G.B.; Henkle, C.; Glover, R.

    2012-01-01

    Accurate topographic data are critical to restoration science and planning for the Everglades region of South Florida, USA. They are needed to monitor and simulate water level, water depth and hydroperiod and are used in scientific research on hydrologic and biologic processes. Because large wetland environments and data acquisition challenge conventional ground-based and remotely sensed data collection methods, the United States Geological Survey (USGS) adapted a classical data collection instrument to global positioning system (GPS) and geographic information system (GIS) technologies. Data acquired with this instrument were processed using geostatistics to yield sub-water level elevation values with centimetre accuracy (??15 cm). The developed database framework, modelling philosophy and metadata protocol allow for continued, collaborative model revision and expansion, given additional elevation or other ancillary data. ?? 2012 Taylor & Francis.

  18. Positive Solutions of Advanced Differential Systems

    Directory of Open Access Journals (Sweden)

    Josef Diblík

    2013-01-01

    graph coordinates of two (lower and upper auxiliary vector functions. This result is applied to scalar advanced linear differential equations. Criteria of existence of positive solutions are given and their asymptotic behavior is discussed.

  19. Global Differential Geometry and Global Analysis

    CERN Document Server

    Pinkall, Ulrich; Simon, Udo; Wegner, Berd

    1991-01-01

    All papers appearing in this volume are original research articles and have not been published elsewhere. They meet the requirements that are necessary for publication in a good quality primary journal. E.Belchev, S.Hineva: On the minimal hypersurfaces of a locally symmetric manifold. -N.Blasic, N.Bokan, P.Gilkey: The spectral geometry of the Laplacian and the conformal Laplacian for manifolds with boundary. -J.Bolton, W.M.Oxbury, L.Vrancken, L.M. Woodward: Minimal immersions of RP2 into CPn. -W.Cieslak, A. Miernowski, W.Mozgawa: Isoptics of a strictly convex curve. -F.Dillen, L.Vrancken: Generalized Cayley surfaces. -A.Ferrandez, O.J.Garay, P.Lucas: On a certain class of conformally flat Euclidean hypersurfaces. -P.Gauduchon: Self-dual manifolds with non-negative Ricci operator. -B.Hajduk: On the obstruction group toexistence of Riemannian metrics of positive scalar curvature. -U.Hammenstaedt: Compact manifolds with 1/4-pinched negative curvature. -J.Jost, Xiaowei Peng: The geometry of moduli spaces of stabl...

  20. The Mathematics of the Global Positioning System.

    Science.gov (United States)

    Nord, Gail D.; Jabon, David; Nord, John

    1997-01-01

    Presents an activity that illustrates the application of mathematics to modern navigation and utilizes the Global Positioning System (GPS). GPS is a constellation of 24 satellites that enables receivers to compute their position anywhere on the earth with great accuracy. (DDR)

  1. Positive solutions of advanced differential systems.

    Science.gov (United States)

    Diblík, Josef; Kúdelčíková, Mária

    2013-01-01

    We study asymptotic behavior of solutions of general advanced differential systems y(t) = F(t, y(t)), where F : Ω → [Symbol: see text] (n) is a continuous quasi-bounded functional which satisfies a local Lipschitz condition with respect to the second argument and Ω is a subset in [Symbol: see text] × C(r)(n), C(r)(n) := C([0, r], [Symbol: see text] (n)), y t [Symbol: see text]C(r)(n), and y t (θ) = y(t + θ), θ [Symbol: see text] [0, r]. A monotone iterative method is proposed to prove the existence of a solution defined for t → ∞ with the graph coordinates lying between graph coordinates of two (lower and upper) auxiliary vector functions. This result is applied to scalar advanced linear differential equations. Criteria of existence of positive solutions are given and their asymptotic behavior is discussed.

  2. Strategic Positioning of IT in Global Organizations

    DEFF Research Database (Denmark)

    Siurdyban, Artur

    2010-01-01

    Executives in large global corporations are faced with a number of non-alternative decision parameters determining the strategic positioning of their IT units. These parameters include organizational structures, competence development and distribution among central and local levels, goal setting...... and type of value contributed to the organization. Although the existing body of research addresses these issues in numerous ways, the concepts have not been fully applied in practice. This paper proposes a tool for strategic positioning of IT in large global companies. It contributes to the overall...... understanding of the role of IT in value creation from a business process perspective, and at the same time practitioners may use it to diagnose, communicate and plan IT positioning in their companies. The tool consists of visual maps assigning different steps of the business process management lifecycle...

  3. Global Positioning System III (GPS III)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-292 Global Positioning System III ( GPS III) As of FY 2017 President’s Budget Defense...Acquisition Management Information Retrieval (DAMIR) March 23, 2016 16:15:29 UNCLASSIFIED GPS III December 2015 SAR March 23, 2016 16:15:29 UNCLASSIFIED 2...Document OSD - Office of the Secretary of Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost GPS III December 2015 SAR March 23

  4. PHYSICS UPDATE: The global positioning system

    Science.gov (United States)

    Walton, Alan J.; Black, Richard J.

    1999-01-01

    A hand-held global positioning system receiver displays the operator's latitude, longitude and velocity. Knowledge of GCSE-level physics will allow the basic principles of the system to be understood; knowledge of A-level physics will allow many important aspects of their implementation to be comprehended. A discussion of the system provides many simple numerical calculations relevant to school and first-year undergraduate syllabuses.

  5. Global Positioning System receiver evaluation results

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, R.H.

    1993-09-01

    A Sandia project currently uses an outdated Magnavox 6400 Global Positioning System (GPS) receiver as the core of its navigation system. The goal of this study was to analyze the performance of the current GPS receiver compared to newer, less expensive models and to make recommendations on how to improve the performance of the overall navigation system. This paper discusses the test methodology used to experimentally analyze the performance of different GPS receivers, the test results, and recommendations on how an upgrade should proceed. Appendices contain detailed information regarding the raw data, test hardware, and test software.

  6. Relativity in the Global Positioning System

    Directory of Open Access Journals (Sweden)

    Ashby Neil

    2003-01-01

    Full Text Available The Global Positioning System (GPS uses accurate, stable atomic clocks in satellites and on the ground to provide world-wide position and time determination. These clocks have gravitational and motional frequency shifts which are so large that, without carefully accounting for numerous relativistic effects, the system would not work. This paper discusses the conceptual basis, founded on special and general relativity, for navigation using GPS. Relativistic principles and effects which must be considered include the constancy of the speed of light, the equivalence principle, the Sagnac effect, time dilation, gravitational frequency shifts, and relativity of synchronization. Experimental tests of relativity obtained with a GPS receiver aboard the TOPEX/POSEIDON satellite will be discussed. Recently frequency jumps arising from satellite orbit adjustments have been identified as relativistic effects. These will be explained and some interesting applications of GPS will be discussed.

  7. Space Weather and the Global Positioning System

    Science.gov (United States)

    Coster, Anthea; Komjathy, Attila

    2008-06-01

    The ability to monitor space weather in near-real time is required as our society becomes increasingly dependent on technological systems such as the Global Positioning System (GPS). Certain critical applications such as railway control, highway traffic management, emergency response, commercial aviation, and marine navigation require high-precision positioning. As a consequence, these applications require real-time knowledge of space weather effects. In recent years, GPS itself has become recognized as one of the premier remote sensing tools to monitor space weather events. For this reason, Space Weather has opened a special section called "Space Weather Effects on GPS." Papers in this section describe the use of GPS as a monitor of space weather events and discuss how GPS is used to observe ionospheric irregularities and total electron content gradients. Other papers address the implications that these space weather features may have on GPS and on Global Navigation Satellite System (GNSS) operations in general. Space weather impacts on GPS include the introduction of range errors and the loss of signal reception, both of which can have severe effects on marine and aviation navigation, surveying, and other critical real-time applications.

  8. Global positioning system theory and practice

    CERN Document Server

    Hofmann-Wellenhof, Bernhard; Collins, James

    2001-01-01

    This book is dedicated to Dr. Benjamin William Remondi for many reasons. The project of writing a Global Positioning System (GPS) book was con­ ceived in April 1988 at a GPS meeting in Darmstadt, Germany. Dr. Remondi discussed with me the need for an additional GPS textbook and suggested a possible joint effort. In 1989, I was willing to commit myself to such a project. Unfortunately, the timing was less than ideal for Dr. Remondi. Therefore, I decided to start the project with other coauthors. Dr. Remondi agreed and indicated his willingness to be a reviewer. I selected Dr. Herbert Lichtenegger, my colleague from the Technical University Graz, Austria, and Dr. James Collins from Rockville, Maryland, U.S.A. In my opinion, the knowledge ofthe three authors should cover the wide spectrum of GPS. Dr. Lichtenegger is a geodesist with broad experience in both theory and practice. He has specialized his research to geodetic astron­ omy including orbital theory and geodynamical phenomena. Since 1986, Dr. Lichteneg...

  9. Global Positioning System wide area augmentation system (WAAS) performance standard.

    Science.gov (United States)

    2008-10-31

    The U.S. Global Positioning System (GPS) Standard Positioning Service (SPS) consists of spacebased : positioning, navigation, and timing (PNT) signals generated from space vehicles orbiting the : earth and delivered free of direct user fees for civil...

  10. Connect Global Positioning System RF Module

    Science.gov (United States)

    Franklin, Garth W.; Young, Lawrence E.; Ciminera, Michael A.; Tien, Jeffrey Y.; Gorelik, Jacob; Okihiro, Brian Bachman; Koelewyn, Cynthia L.

    2012-01-01

    The CoNNeCT Global Positioning System RF Module (GPSM) slice is part of the JPL CoNNeCT Software Defined Radio (SDR). CoNNeCT is the Communications, Navigation, and Net working reconfigurable Testbed project that is part of NASA's Space Communication and Nav igation (SCaN) Program. The CoNNeCT project is an experimental dem onstration that will lead to the advancement of SDRs and provide a path for new space communication and navigation systems for future NASA exploration missions. The JPL CoNNeCT SDR will be flying on the International Space Station (ISS) in 2012 in support of the SCaN CoNNeCT program. The GPSM is a radio-frequency sampler module (see Figure 1) that directly sub-harmonically samples the filtered GPS L-band signals at L1 (1575.42 MHz), L2 (1227.6 MHz), and L5 (1176.45 MHz). The JPL SDR receives GPS signals through a Dorne & Margolin antenna mounted onto a choke ring. The GPS signal is filtered against interference, amplified, split, and fed into three channels: L1, L2, and L5. In each of the L-band channels, there is a chain of bandpass filters and amplifiers, and the signal is fed through each of these channels to where the GPSM performs a one-bit analog-to-digital conversion (see Figure 2). The GPSM uses a sub-harmonic, single-bit L1, L2, and L5 sampler that samples at a clock rate of 38.656 MHz. The new capability is the down-conversion and sampling of the L5 signal when previous hardware did not provide this capability. The first GPS IIF Satellite was launched in 2010, providing the new L5 signal. With the JPL SDR flying on the ISS, it will be possible to demonstrate navigation solutions with 10-meter 3-D accuracy at 10-second intervals using a field-program mable gate array (FPGA)-based feedback loop running at 50 Hz. The GPS data bits will be decoded and used in the SDR. The GPSM will also allow other waveforms that are installed in the SDR to demonstrate various GNSS tracking techniques.

  11. Signal differentiation in position tracking control of dc motors

    International Nuclear Information System (INIS)

    Beltran-Carbajal, F; Valderrabano-Gonzalez, A; Rosas-Caro, J C

    2015-01-01

    An asymptotic differentiation approach with respect to time is used for on-line estimation of velocity and acceleration signals in controlled dc motors. The attractive feature of this differentiator of signals is that it does not require any system mathematical model, which allows its use in engineering systems that require the signal differentiation for its control, identification, fault detection, among other applications. Moreover, it is shown that the differentiation approach can be applied for output signals showing a chaotic behavior. In addition a differential flatness control scheme with additional integral compensation of the output error is proposed for tracking tasks of position reference trajectories for direct current electric motors using angular position measurements only

  12. Asymptotic behavior of positive solutions of the nonlinear differential equation t^2u''=u^n

    Directory of Open Access Journals (Sweden)

    Meng-Rong Li

    2013-11-01

    Full Text Available In this article we study properties of positive solutions of the ordinary differential equation $t^2u''=u^n$ for $1global solutions. Equations containing more general nonlinear terms are also considered.

  13. Euthanasia: India's position in the global scenario.

    Science.gov (United States)

    Shekhar, Skand; Goel, Ashish

    2013-11-01

    Euthanasia requests have increased as the number of debilitated patients rises in both developed and developing countries such as India due to medical, psychosocial-emotional, socioenvironmental, and existential issues amid fears of potential misuse. WORLD'S POSITION: Albania, Colombia, the Netherlands, and Switzerland permit euthanasia conditionally. Australia's legalization of euthanasia has been withdrawn. The United States permits withdrawal of life support. Mexico and Norway permit active euthanasia. INDIA'S POSITION: Following the Aruna Shanbaug case the Supreme Court granted legal sanction to passive, but not active, euthanasia that is valid till the Parliament legislates on euthanasia. HANDLING EUTHANASIA REQUESTS: Acknowledging the complexity of the problem; individualizing the palliative approach; and accepting the 'There is no alternative' or 'There is no answer' (TINA) factor.

  14. Error Analysis of Determining Airplane Location by Global Positioning System

    OpenAIRE

    Hajiyev, Chingiz; Burat, Alper

    1999-01-01

    This paper studies the error analysis of determining airplane location by global positioning system (GPS) using statistical testing method. The Newton Rhapson method positions the airplane at the intersection point of four spheres. Absolute errors, relative errors and standard deviation have been calculated The results show that the positioning error of the airplane varies with the coordinates of GPS satellite and the airplane.

  15. Gender wage-productivity differentials and global integration in China

    OpenAIRE

    Dammert, Ana C.; Ural Marchand, Beyza; Wan, Chi

    2013-01-01

    In the absence of discrimination, there should be no wage-productivity differentials as relative wages should be equal to the relative marginal productivity levels of workers. This paper investigates the role of globalization on the structure and evolution of gender differentials in China by simultaneously estimating demand-side wage and productivity outcomes using nonlinear least squares. The analyses are based on a comprehensive population-wide panel survey of manufacturing firms between th...

  16. Global positioning system (GPS) civil monitoring performance specification.

    Science.gov (United States)

    2009-04-30

    This Civil Monitoring Performance Specification (CMPS) is published and maintained at : the direction of the Program Manager for Civil Applications, Global Positioning Systems : Wing (GPSW). The purpose of this document is to provide a comprehensive ...

  17. Differential evolution algorithm for global optimizations in nuclear physics

    Science.gov (United States)

    Qi, Chong

    2017-04-01

    We explore the applicability of the differential evolution algorithm in finding the global minima of three typical nuclear structure physics problems: the global deformation minimum in the nuclear potential energy surface, the optimization of mass model parameters and the lowest eigenvalue of a nuclear Hamiltonian. The algorithm works very effectively and efficiently in identifying the minima in all problems we have tested. We also show that the algorithm can be parallelized in a straightforward way.

  18. A Unified Differential Evolution Algorithm for Global Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji; Mitchell, Chad

    2014-06-24

    Abstract?In this paper, we propose a new unified differential evolution (uDE) algorithm for single objective global optimization. Instead of selecting among multiple mutation strategies as in the conventional differential evolution algorithm, this algorithm employs a single equation as the mutation strategy. It has the virtue of mathematical simplicity and also provides users the flexbility for broader exploration of different mutation strategies. Numerical tests using twelve basic unimodal and multimodal functions show promising performance of the proposed algorithm in comparison to convential differential evolution algorithms.

  19. A theoretical ovary position in link with the global anatomical ...

    African Journals Online (AJOL)

    Generally the position of different organs is determined by simple description following the anatomical elements surrounded them and such description could be developed and applied in surgical anatomy. Here, I present for the first time a theoretical three-dimensional ovary position in link with the global anatomical ...

  20. Global positioning system : challenges in sustaining and upgrading capabilities persist.

    Science.gov (United States)

    2010-09-01

    The Global Positioning System (GPS) provides positioning, navigation, and timing (PNT) data to users worldwide. The U.S. Air Force, which is responsible for GPS acquisition, is in the process of modernizing the system. Last year GAO reported that it ...

  1. Global Positioning Radiometric Scanner System. Innovative Technology Summary Report

    International Nuclear Information System (INIS)

    2001-01-01

    The US DOE continually seeks safer and more cost-effective technologies for use in decontamination and decommissioning (D and D) of nuclear facilities. To this end, the Deactivation and Decommissioning Focus Area (DDFA) of the DOE OST sponsors the Large Scale Demonstration and Deployment Projects (LSDDP). At these LSDDPs, developers and vendors of improved or innovative technologies showcase products that are potentially beneficial to the DOE projects and to others in the D and D community. Benefits sought include decreased health and safety risks to personnel and the environment, increased productivity, and decreased costs of operation. The Idaho National Engineering and Environmental Laboratory (INEEL) LSDDP generated a list of statements defining specific needs or problems where improved technology could be incorporated into ongoing D and D tasks. One of the stated needs was for developing technologies that would reduce costs and shorten DDOE/EM--0552DOE/EM--0552 and D schedules by providing radiological characterizations to meet the free-release criteria. The Global Positioning Radiometric Scanner (GPRS system shown in Figure 1) utilizes a detection system; a portable computer, a differential global positioning system (d-gps), and a four wheel drive vehicle. Once the survey data has been collected, a software program called GeoSofttrademark generates a graphical representation of the radiological contamination extent. Baseline technology involves gridding the area and hand surveying each grid. This demonstration investigated the associated costs and the required time to evaluate the radiological characterization data from the GPRS with respect to the baseline technology. The GPRS system performs in-situ, real-time analyses to identify the extent of radiological contamination. Benefits expected from using the new innovative technology (GPRS) include: Reduced labor hours associated with performing the survey; Increased number of survey data points; Reduced

  2. Multiple Positive Solutions for Nonlinear Semipositone Fractional Differential Equations

    Directory of Open Access Journals (Sweden)

    Wen-Xue Zhou

    2012-01-01

    Full Text Available We present some new multiplicity of positive solutions results for nonlinear semipositone fractional boundary value problem D0+αu(t=p(tf(t,u(t-q(t,0differentiation. One example is also given to illustrate the main result.

  3. Positive Solutions for Coupled Nonlinear Fractional Differential Equations

    Directory of Open Access Journals (Sweden)

    Wenning Liu

    2014-01-01

    Full Text Available We consider the existence of positive solutions for a coupled system of nonlinear fractional differential equations with integral boundary values. Assume the nonlinear term is superlinear in one equation and sublinear in the other equation. By constructing two cones K1, K2 and computing the fixed point index in product cone K1×K2, we obtain that the system has a pair of positive solutions. It is remarkable that it is established on the Cartesian product of two cones, in which the feature of two equations can be opposite.

  4. DEoptim: An R Package for Global Optimization by Differential Evolution

    Directory of Open Access Journals (Sweden)

    Katharine M. Mullen

    2011-04-01

    Full Text Available This article describes the R package DEoptim, which implements the differential evolution algorithm for global optimization of a real-valued function of a real-valued parameter vector. The implementation of differential evolution in DEoptim interfaces with C code for efficiency. The utility of the package is illustrated by case studies in fitting a Parratt model for X-ray reflectometry data and a Markov-switching generalized autoregressive conditional heteroskedasticity model for the returns of the Swiss Market Index.

  5. Indoor positioning using differential Wi-Fi lateration

    Science.gov (United States)

    Retscher, Guenther; Tatschl, Thomas

    2017-12-01

    For Wi-Fi positioning usually location fingerprinting or (tri)lateration are employed whereby the received signal strengths (RSSs) of the surrounding Wi-Fi Access Points (APs) are scanned on the mobile devices and used to perform localization. Within the scope of this study, the position of a mobile user is determined on the basis of lateration. Two new differential approaches are developed and compared to two common models, i.e., the one-slope and multi-wall model, for the conversion of the measured RSS of the Wi-Fi signals into ranges. The two novel methods are termed DWi-Fi as they are derived either from the well-known DGPS or VLBI positioning principles. They make use of a network of reference stations deployed in the area of interest. From continuous RSS observations on these reference stations correction parameters are derived and applied by the user in real-time. This approach leads to a reduced influence of temporal and spatial variations and various propagation effects on the positioning result. In practical use cases conducted in a multi-storey office building with three different smartphones, it is proven that the two DWi-Fi approaches outperform the common models as static positioning yielded to position errors of about 5 m in average under good spatial conditions.

  6. An Adaptive Unified Differential Evolution Algorithm for Global Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji; Mitchell, Chad

    2014-11-03

    In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the multiple mutation strate- gies proposed in conventional differential evolution algorithms, this algorithm employs a single equation unifying multiple strategies into one expression. It has the virtue of mathematical simplicity and also provides users the flexibility for broader exploration of the space of mutation operators. By making all control parameters in the proposed algorithm self-adaptively evolve during the process of optimization, it frees the application users from the burden of choosing appro- priate control parameters and also improves the performance of the algorithm. In numerical tests using thirteen basic unimodal and multimodal functions, the proposed adaptive unified algorithm shows promising performance in compari- son to several conventional differential evolution algorithms.

  7. Tracking elk hunters with the Global Positioning System

    Science.gov (United States)

    L. Jack Lyon; Milo G. Burcham

    1998-01-01

    Global Positioning System (GPS) units were used to record hunter locations at 15 second intervals during elk hunting expeditions. This information allowed us to examine the influence of roads on hunter behavior, and along with associated time and distance data, provide a solid foundation on which a hunter density and elk vulnerability model can be developed.

  8. Cost analysis of Navy acquisition alternatives for the NAVSTAR Global Positioning System

    Science.gov (United States)

    Darcy, T. F.; Smith, G. P.

    1982-12-01

    This research analyzes the life cycle cost (LCC) of the Navy's current and two hypothetical procurement alternatives for NAVSTAR Global Positioning System (GPS) user equipment. Costs are derived by the ARINC Research Corporation ACBEN cost estimating system. Data presentation is in a comparative format describing individual alternative LCC and differential costs between alternatives. Sensitivity analysis explores the impact receiver-processor unit (RPU) first unit production cost has on individual alternative LCC, as well as cost differentials between each alternative. Several benefits are discussed that might provide sufficient cost savings and/or system effectiveness improvements to warrant a procurement strategy other than the existing proposal.

  9. Position of the European Union in the Global Trade System

    Directory of Open Access Journals (Sweden)

    Jovićević Mladen

    2017-12-01

    Full Text Available Only a few decades ago, the main drivers of globalization were the exchange of goods and capital flows, while the global trading system of today, fuelled by rapid technological changes increasingly bases itself on knowledge. The Key events - such as the use of the Internet and the increasingly important role of the rising countries economies - have contributed to a faster global exchange, but to a new nature as well. In order to illustrate the scope of the increase, perhaps it would be the best to mention the fact that in the 1970’s the share of trade in the world GDP amounted to 20%, whereas today it makes about one half. On the other hand, modern products represent compounds of raw materials, components, technologies and services originating from different areas and different continents, which has globalized the products themselves. In such conditions of the market competition, imposed by globalization and liberalization, for the European Union to remain as a leader, it had to prepare a sound and well-founded foreign policy strategy. The aim of this paper is to analyse the current position of the European Union in the global trading system, instruments of foreign trade policy, goals, foreign trade and the main challenges placed before the Union.

  10. Positive biodiversity-productivity relationship predominant in global forests.

    Science.gov (United States)

    Liang, Jingjing; Crowther, Thomas W; Picard, Nicolas; Wiser, Susan; Zhou, Mo; Alberti, Giorgio; Schulze, Ernst-Detlef; McGuire, A David; Bozzato, Fabio; Pretzsch, Hans; de-Miguel, Sergio; Paquette, Alain; Hérault, Bruno; Scherer-Lorenzen, Michael; Barrett, Christopher B; Glick, Henry B; Hengeveld, Geerten M; Nabuurs, Gert-Jan; Pfautsch, Sebastian; Viana, Helder; Vibrans, Alexander C; Ammer, Christian; Schall, Peter; Verbyla, David; Tchebakova, Nadja; Fischer, Markus; Watson, James V; Chen, Han Y H; Lei, Xiangdong; Schelhaas, Mart-Jan; Lu, Huicui; Gianelle, Damiano; Parfenova, Elena I; Salas, Christian; Lee, Eungul; Lee, Boknam; Kim, Hyun Seok; Bruelheide, Helge; Coomes, David A; Piotto, Daniel; Sunderland, Terry; Schmid, Bernhard; Gourlet-Fleury, Sylvie; Sonké, Bonaventure; Tavani, Rebecca; Zhu, Jun; Brandl, Susanne; Vayreda, Jordi; Kitahara, Fumiaki; Searle, Eric B; Neldner, Victor J; Ngugi, Michael R; Baraloto, Christopher; Frizzera, Lorenzo; Bałazy, Radomir; Oleksyn, Jacek; Zawiła-Niedźwiecki, Tomasz; Bouriaud, Olivier; Bussotti, Filippo; Finér, Leena; Jaroszewicz, Bogdan; Jucker, Tommaso; Valladares, Fernando; Jagodzinski, Andrzej M; Peri, Pablo L; Gonmadje, Christelle; Marthy, William; O'Brien, Timothy; Martin, Emanuel H; Marshall, Andrew R; Rovero, Francesco; Bitariho, Robert; Niklaus, Pascal A; Alvarez-Loayza, Patricia; Chamuya, Nurdin; Valencia, Renato; Mortier, Frédéric; Wortel, Verginia; Engone-Obiang, Nestor L; Ferreira, Leandro V; Odeke, David E; Vasquez, Rodolfo M; Lewis, Simon L; Reich, Peter B

    2016-10-14

    The biodiversity-productivity relationship (BPR) is foundational to our understanding of the global extinction crisis and its impacts on ecosystem functioning. Understanding BPR is critical for the accurate valuation and effective conservation of biodiversity. Using ground-sourced data from 777,126 permanent plots, spanning 44 countries and most terrestrial biomes, we reveal a globally consistent positive concave-down BPR, showing that continued biodiversity loss would result in an accelerating decline in forest productivity worldwide. The value of biodiversity in maintaining commercial forest productivity alone-US$166 billion to 490 billion per year according to our estimation-is more than twice what it would cost to implement effective global conservation. This highlights the need for a worldwide reassessment of biodiversity values, forest management strategies, and conservation priorities. Copyright © 2016, American Association for the Advancement of Science.

  11. On global asymptotic stability of solutions of a system of ordinary differential equations

    Science.gov (United States)

    Filimonov, M. Yu.

    2017-12-01

    To investigate global asymptotic stability in general of an equilibrium position of an autonomous system of ordinary differential equations, considered by V.A. Pliss, a function different from the Lyapunov functions is applied. V.A. Pliss proved that for this system it is impossible to construct the Lyapunov function as a sum of a quadratic form and an integral of some nonlinear function defined by the right-hand side of the system.

  12. Global Positioning System: Political Support, Directions of Development, and Expectations

    Directory of Open Access Journals (Sweden)

    Krzysztof Czaplewski

    2015-06-01

    Full Text Available Over the last decade the Global Positioning System has become a global, multifunctional tool which provides services that are an integral part of U.S. national security as well as the security of other highly developed countries. Economic development, transport security as well as homeland security are important elements of the global economic infrastructure. In 2000 the United States acknowledged the growing significance of GPS for civilian users and stopped intentionally degrading accuracy for non-military signals that are known as “Selective Availability”. Since then, commercial applications of satellite systems have been proliferating even more rapidly, and therefore, their importance in everyday life has greatly increased. Currently, services that depend on information obtained from the Global Positioning System are the driving force behind economic growth, economic development and the improvement in life safety. This economic development would not be possible without the financial and political support of the US government to maintain the operation of the GPS system. Therefore it is important to have knowledge about the intentions of the US government how system GPS will be developed in the future. Decisions taken in the last 3 months are the subject of this article.

  13. The effect of different Global Navigation Satellite System methods on positioning accuracy in elite alpine skiing.

    Science.gov (United States)

    Gilgien, Matthias; Spörri, Jörg; Limpach, Philippe; Geiger, Alain; Müller, Erich

    2014-10-03

    In sport science, Global Navigation Satellite Systems (GNSS) are frequently applied to capture athletes' position, velocity and acceleration. Application of GNSS includes a large range of different GNSS technologies and methods. To date no study has comprehensively compared the different GNSS methods applied. Therefore, the aim of the current study was to investigate the effect of differential and non-differential solutions, different satellite systems and different GNSS signal frequencies on position accuracy. Twelve alpine ski racers were equipped with high-end GNSS devices while performing runs on a giant slalom course. The skiers' GNSS antenna positions were calculated in three satellite signal obstruction conditions using five different GNSS methods. The GNSS antenna positions were compared to a video-based photogrammetric reference system over one turn and against the most valid GNSS method over the entire run. Furthermore, the time for acquisitioning differential GNSS solutions was assessed for four differential methods. The only GNSS method that consistently yielded sub-decimetre position accuracy in typical alpine skiing conditions was a differential method using American (GPS) and Russian (GLONASS) satellite systems and the satellite signal frequencies L1 and L2. Under conditions of minimal satellite signal obstruction, valid results were also achieved when either the satellite system GLONASS or the frequency L2 was dropped from the best configuration. All other methods failed to fulfill the accuracy requirements needed to detect relevant differences in the kinematics of alpine skiers, even in conditions favorable for GNSS measurements. The methods with good positioning accuracy had also the shortest times to compute differential solutions. This paper highlights the importance to choose appropriate methods to meet the accuracy requirements for sport applications.

  14. The Effect of Different Global Navigation Satellite System Methods on Positioning Accuracy in Elite Alpine Skiing

    Directory of Open Access Journals (Sweden)

    Matthias Gilgien

    2014-10-01

    Full Text Available In sport science, Global Navigation Satellite Systems (GNSS are frequently applied to capture athletes’ position, velocity and acceleration. Application of GNSS includes a large range of different GNSS technologies and methods. To date no study has comprehensively compared the different GNSS methods applied. Therefore, the aim of the current study was to investigate the effect of differential and non-differential solutions, different satellite systems and different GNSS signal frequencies on position accuracy. Twelve alpine ski racers were equipped with high-end GNSS devices while performing runs on a giant slalom course. The skiers’ GNSS antenna positions were calculated in three satellite signal obstruction conditions using five different GNSS methods. The GNSS antenna positions were compared to a video-based photogrammetric reference system over one turn and against the most valid GNSS method over the entire run. Furthermore, the time for acquisitioning differential GNSS solutions was assessed for four differential methods. The only GNSS method that consistently yielded sub-decimetre position accuracy in typical alpine skiing conditions was a differential method using American (GPS and Russian (GLONASS satellite systems and the satellite signal frequencies L1 and L2. Under conditions of minimal satellite signal obstruction, valid results were also achieved when either the satellite system GLONASS or the frequency L2 was dropped from the best configuration. All other methods failed to fulfill the accuracy requirements needed to detect relevant differences in the kinematics of alpine skiers, even in conditions favorable for GNSS measurements. The methods with good positioning accuracy had also the shortest times to compute differential solutions. This paper highlights the importance to choose appropriate methods to meet the accuracy requirements for sport applications.

  15. The Effect of Different Global Navigation Satellite System Methods on Positioning Accuracy in Elite Alpine Skiing

    Science.gov (United States)

    Gilgien, Matthias; Spörri, Jörg; Limpach, Philippe; Geiger, Alain; Müller, Erich

    2014-01-01

    In sport science, Global Navigation Satellite Systems (GNSS) are frequently applied to capture athletes' position, velocity and acceleration. Application of GNSS includes a large range of different GNSS technologies and methods. To date no study has comprehensively compared the different GNSS methods applied. Therefore, the aim of the current study was to investigate the effect of differential and non-differential solutions, different satellite systems and different GNSS signal frequencies on position accuracy. Twelve alpine ski racers were equipped with high-end GNSS devices while performing runs on a giant slalom course. The skiers' GNSS antenna positions were calculated in three satellite signal obstruction conditions using five different GNSS methods. The GNSS antenna positions were compared to a video-based photogrammetric reference system over one turn and against the most valid GNSS method over the entire run. Furthermore, the time for acquisitioning differential GNSS solutions was assessed for four differential methods. The only GNSS method that consistently yielded sub-decimetre position accuracy in typical alpine skiing conditions was a differential method using American (GPS) and Russian (GLONASS) satellite systems and the satellite signal frequencies L1 and L2. Under conditions of minimal satellite signal obstruction, valid results were also achieved when either the satellite system GLONASS or the frequency L2 was dropped from the best configuration. All other methods failed to fulfill the accuracy requirements needed to detect relevant differences in the kinematics of alpine skiers, even in conditions favorable for GNSS measurements. The methods with good positioning accuracy had also the shortest times to compute differential solutions. This paper highlights the importance to choose appropriate methods to meet the accuracy requirements for sport applications. PMID:25285461

  16. Possible application of differential global positioning system (DGPS ...

    African Journals Online (AJOL)

    The significant influence of the varying altitude above sea level (from 389 to 462 m) on the concentration of total sugar and the total titratable acidity of grapes were estimated during the ripeness of vine berry from July to September. The results of a five-year study proved that significant improvement of the grapes quality is ...

  17. Possible application of differential global positioning system (DGPS ...

    African Journals Online (AJOL)

    hope&shola

    2010-11-29

    Nov 29, 2010 ... the vineyards lying higher as 550 m. The main objective of our investigation is to ... 02' 53.27004" N, Lon = 14° 32' 37.36262" E). The site is divided into four parcels lying on differently oriented ... experiments were performed on the Single Guyot trained grape- vines, which were grafted on the 'Kober 5BB' ...

  18. Nationwide differential global positioning system (NDGPS) : capabilities and potential.

    Science.gov (United States)

    2009-06-01

    NDGPS is a National PNT Utility: : -Operated/managed by Coast Guard as a Combined NDGPS (Maritime + DOT + ACOE sites) : -System Specifications : --Corrections broadcast at 285 and 325 kHz using Minimum shift Keying (MSK) modulation : --Real-time diff...

  19. 78 FR 22554 - Nationwide Differential Global Positioning System (NDGPS)

    Science.gov (United States)

    2013-04-16

    ... future usage of the NDGPS, the need to retain the NDGPS, the impact if NDGPS signals were not available... public regarding current and future usage of the NDGPS, the need to retain the NDGPS, the impact if NDGPS... to the Internet, you may view the docket online by visiting the Docket Management Facility in Room...

  20. Lissajous trajectories for lunar global positioning and communication systems

    Science.gov (United States)

    Romagnoli, Daniele; Circi, Christian

    2010-08-01

    This work proposes a Lunar Global Positioning System (LGPS) and a Lunar Global Communication System (LGCS) using two constellations of satellites on Lissajous trajectories around the collinear L 1 and L 2 libration points in the Earth-Moon system. This solution is compared against a Walker constellation around the Moon similar to the one used for the Global Positioning System (GPS) on the Earth to evaluate the main differences between the two cases and the advantages of adopting the Lissajous constellations. The problem is first studied using the Circular Restricted Three Body Problem to find out its main features. The study is then repeated with higher fidelity using a four-body model and higher-order reference trajectories to simulate the Earth-Moon-spacecraft dynamics more accurately. The LGPS performance is evaluated for both on-ground and in-flight users, and a visibility study for the LGCS is used to check that communication between opposite sides of the Moon is possible. The total Δ V required for the transfer trajectories from the Earth to the constellations and the trajectory control is calculated. Finally, the estimated propellant consumption and the total number of satellites for the Walker constellation and the Lissajous constellations is used as a performance index to compare the two proposed solutions.

  1. Romania's Competitiveness and Competitive Position in Global Context

    Directory of Open Access Journals (Sweden)

    Valentin NECULITA

    2012-08-01

    Full Text Available Competitiveness increase has become a primordial framework of the social and economic development strategies of most world countries (mainly the most developed ones over the last decades. The vigorous boost of the contemporary phenomenon of globalization, which has widened the global area of economies, sectors and firms confrontation, has laid an emphasis on their competitiveness importance for their favorable position in the international competition and has therefore force the status to take proper, broad and concerted measures to stimulate the determining factors of action and to take better advantage of their effects. The purpose of the paper is to determine whether an increase in competitiveness could reduce the disparities between regions. The E.U. Member States and regions need significant financial help to solve various structural problems and to achieve their potential of growth. Romania is no exception, one of the main problems being the low rate in attracting European funds.

  2. Atmospheric pressure loading effects on Global Positioning System coordinate determinations

    Science.gov (United States)

    Vandam, Tonie M.; Blewitt, Geoffrey; Heflin, Michael B.

    1994-01-01

    Earth deformation signals caused by atmospheric pressure loading are detected in vertical position estimates at Global Positioning System (GPS) stations. Surface displacements due to changes in atmospheric pressure account for up to 24% of the total variance in the GPS height estimates. The detected loading signals are larger at higher latitudes where pressure variations are greatest; the largest effect is observed at Fairbanks, Alaska (latitude 65 deg), with a signal root mean square (RMS) of 5 mm. Out of 19 continuously operating GPS sites (with a mean of 281 daily solutions per site), 18 show a positive correlation between the GPS vertical estimates and the modeled loading displacements. Accounting for loading reduces the variance of the vertical station positions on 12 of the 19 sites investigated. Removing the modeled pressure loading from GPS determinations of baseline length for baselines longer than 6000 km reduces the variance on 73 of the 117 baselines investigated. The slight increase in variance for some of the sites and baselines is consistent with expected statistical fluctuations. The results from most stations are consistent with approximately 65% of the modeled pressure load being found in the GPS vertical position measurements. Removing an annual signal from both the measured heights and the modeled load time series leaves this value unchanged. The source of the remaining discrepancy between the modeled and observed loading signal may be the result of (1) anisotropic effects in the Earth's loading response, (2) errors in GPS estimates of tropospheric delay, (3) errors in the surface pressure data, or (4) annual signals in the time series of loading and station heights. In addition, we find that using site dependent coefficients, determined by fitting local pressure to the modeled radial displacements, reduces the variance of the measured station heights as well as or better than using the global convolution sum.

  3. The global positioning system and ArcGIS

    CERN Document Server

    Kennedy, Michael

    2009-01-01

    Foreword to the First EditionForeword to the Second EditionPreface for the Instructor, Third EditionAcknowledgmentsAbout the AuthorIntroductionChapter 1: Basic Concepts OverviewWhere Are You?What Time Is It?GPS and GISAnatomy of the Term ""Global Positioning System""How We Know Where Something IsStep-by-StepDisclaimerFirst OffDifferent Receivers and Different SoftwarePreparationProject 1AUnderstanding the Screens and ControlsProject 1BProject 1CChapter 2: Automated Data CollectionOverviewHow'd They Do That?How It Works: Measuring Distance by Measuring TimeFactors Affecting When and How to Coll

  4. Global Positioning System Synchronized Active Light Autonomous Docking System

    Science.gov (United States)

    Howard, Richard T. (Inventor); Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor); Bell, Joseph L. (Inventor)

    1996-01-01

    A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprising at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.

  5. Fabricated World Class: Global University League Tables, Status Differentiation and Myths of Global Competition

    Science.gov (United States)

    David, Matthew

    2016-01-01

    UK media coverage of global university league tables shows systematic bias towards the Russell Group, although also highlighting tensions within its membership. Coverage positions UK "elite" institutions between US superiority and Asian ascent. Coverage claims that league table results warrant UK university funding reform. However,…

  6. Differential rotation in solar-like stars from global simulations

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero, G.; Kosovichev, A. G. [Solar Physics, HEPL, Stanford University, 452 Lomita Mall, Stanford, CA 94305-4085 (United States); Smolarkiewicz, P. K. [European Centre for Medium-Range Weather Forecasts, Reading RG2 9AX (United Kingdom); Mansour, N. N., E-mail: gag@stanford.edu, E-mail: sasha@sun.stanford.edu, E-mail: smolar@ecmwf.int, E-mail: nagi.n.mansour@nasa.gov [NASA, Ames Research Center, Moffett Field, Mountain View, CA 94040 (United States)

    2013-12-20

    To explore the physics of large-scale flows in solar-like stars, we perform three-dimensional anelastic simulations of rotating convection for global models with stratification resembling the solar interior. The numerical method is based on an implicit large-eddy simulation approach designed to capture effects from non-resolved small scales. We obtain two regimes of differential rotation, with equatorial zonal flows accelerated either in the direction of rotation (solar-like) or in the opposite direction (anti-solar). While the models with the solar-like differential rotation tend to produce multiple cells of meridional circulation, the models with anti-solar differential rotation result in only one or two meridional cells. Our simulations indicate that the rotation and large-scale flow patterns critically depend on the ratio between buoyancy and Coriolis forces. By including a sub-adiabatic layer at the bottom of the domain, corresponding to the stratification of a radiative zone, we reproduce a layer of strong radial shear similar to the solar tachocline. Similarly, enhanced super-adiabaticity at the top results in a near-surface shear layer located mainly at lower latitudes. The models reveal a latitudinal entropy gradient localized at the base of the convection zone and in the stable region, which, however, does not propagate across the convection zone. In consequence, baroclinicity effects remain small, and the rotation isocontours align in cylinders along the rotation axis. Our results confirm the alignment of large convective cells along the rotation axis in the deep convection zone and suggest that such 'banana-cell' pattern can be hidden beneath the supergranulation layer.

  7. Integrating Content and Language in Institutionally Monolingual Settings: Teacher Positioning and Differentiation

    Science.gov (United States)

    Turner, Marianne

    2017-01-01

    Translanguaging pedagogy offers a way to differentiate between students' varying linguistic repertoires when embedding an additional language across the curriculum. In this article I draw on positioning theory to show the relevance of teacher positioning to translanguaging pedagogy and differentiation. Differentiation is discussed in relation to…

  8. Development of Precise Point Positioning Method Using Global Positioning System Measurements

    Directory of Open Access Journals (Sweden)

    Byung-Kyu Choi

    2011-09-01

    Full Text Available Precise point positioning (PPP is increasingly used in several parts such as monitoring of crustal movement and maintaining an international terrestrial reference frame using global positioning system (GPS measurements. An accuracy of PPP data processing has been increased due to the use of the more precise satellite orbit/clock products. In this study we developed PPP algorithm that utilizes data collected by a GPS receiver. The measurement error modelling including the tropospheric error and the tidal model in data processing was considered to improve the positioning accuracy. The extended Kalman filter has been also employed to estimate the state parameters such as positioning information and float ambiguities. For the verification, we compared our results to other of International GNSS Service analysis center. As a result, the mean errors of the estimated position on the East-West, North-South and Up-Down direction for the five days were 0.9 cm, 0.32 cm, and 1.14 cm in 95% confidence level.

  9. The Global Positioning System: a high-tech success story

    Science.gov (United States)

    Ashby, Neil

    2002-03-01

    The Global Positioning System (GPS) consists of 24 or more satellites in twelve-hour orbits, each carrying atomic clocks and transmitting synchronized time and position information. The satellite system is supported by time referencing and processing centers, and data collection stations around the world. The signals make possible accurate navigation anywhere in the vicinity of Earth. There is probably no other large engineering system that relies on a broader range of applications of fundamental modern physics, such as special and general relativity, and atomic physics. Atomic clocks only a few inches on a side have been developed to an almost incredible stage of reliability and stability. Modern circuit fabrication techniques produce GPS receivers on a chip at cost comparable to that of handheld cell phones. Widespread availability and low cost in the civilian sector has led to a host of interesting applications. The economic impact of GPS is in the billions of dollars annually and is increasing. A comparable system, currently with only a few satellites, is the Soviet GLONASS. Europeans are developing another competitor, GALILEO, and have plans to place Hydrogen masers in space. These systems are changing the way we determine where we are and are revolutionizing many fields of scientific research.

  10. Net and Global Differential Item Functioning in PISA Polytomously Scored Science Items: Application of the Differential Step Functioning Framework

    Science.gov (United States)

    Akour, Mutasem; Sabah, Saed; Hammouri, Hind

    2015-01-01

    The purpose of this study was to apply two types of Differential Item Functioning (DIF), net and global DIF, as well as the framework of Differential Step Functioning (DSF) to real testing data to investigate measurement invariance related to test language. Data from the Program for International Student Assessment (PISA)-2006 polytomously scored…

  11. Positivity and storage functions for quadratic differential forms

    NARCIS (Netherlands)

    Trentelman, Hendrikus; Willems, Jan C.

    1996-01-01

    Differential equations and one-variable polynomial matrices play an essential role in describing dynamics of systems. When studying functions of the dynamical variables or specifying performance criteria in optimal control, we invariably encounter quadratic expressions in the variables and their

  12. 77 FR 56254 - 89th Meeting: RTCA Special Committee 159, Global Positioning Systems (GPS)

    Science.gov (United States)

    2012-09-12

    ... 159, Global Positioning Systems (GPS) AGENCY: Federal Aviation Administration (FAA), U.S. Department... 159, Global Positioning Systems (GPS). SUMMARY: The FAA is issuing this notice to advise the public of the eighty-ninth meeting of the RTCA Special Committee 159, Global Positioning Systems (GPS). DATES...

  13. 78 FR 13396 - 90th Meeting: RTCA Special Committee 159, Global Positioning Systems (GPS)

    Science.gov (United States)

    2013-02-27

    ... 159, Global Positioning Systems (GPS) AGENCY: Federal Aviation Administration (FAA), U.S. Department... 159, Global Positioning Systems (GPS) SUMMARY: The FAA is issuing this notice to advise the public of the eighty-ninth meeting of the RTCA Special Committee 159, Global Positioning Systems (GPS). DATES...

  14. 76 FR 50808 - Airborne Supplemental Navigation Equipment Using the Global Positioning System (GPS)

    Science.gov (United States)

    2011-08-16

    ... Equipment Using the Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT... Navigation Equipment Using the Global Positioning System (GPS), and request for public comment. SUMMARY: This... the Global Positioning System (GPS). The effect of the cancelled TSO will result in no new TSO-C129a...

  15. 78 FR 57672 - 91st Meeting: RTCA Special Committee 159, Global Positioning Systems (GPS)

    Science.gov (United States)

    2013-09-19

    ... 159, Global Positioning Systems (GPS) AGENCY: Federal Aviation Administration (FAA), U.S. Department... 159, Global Positioning Systems (GPS). SUMMARY: The FAA is issuing this notice to advise the public of the ninety-first meeting of the RTCA Special Committee 159, Global Positioning Systems (GPS) DATES...

  16. 77 FR 12106 - 88th Meeting: RTCA Special Committee 159, Global Positioning System (GPS)

    Science.gov (United States)

    2012-02-28

    ... 159, Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 159, Global Positioning System (GPS). SUMMARY: The..., Global Positioning System (GPS). DATES: The meeting will be held March 13-16, 2012, from 9 a.m.-4:30 p.m...

  17. The Contemporary Positions of China in the Conditions of Globalization

    Directory of Open Access Journals (Sweden)

    Khomutenko Liudmyla I.

    2017-12-01

    Full Text Available The current geopolitical situation testifies to a noticeable strengthening of China’s role in the world. The article describes China as the country that occupies a leading position in the world trade. The current status and prospects of development of economy of China in conditions of globalization development were researched. Both the qualitative and quantitative character of the current level of economic integration processes of China with the world economy are described on the basis of the data analysis by the Ministry of Commerce of China. The volume and extent of the China’s FDI movement were analyzed; new trends in the geography of progress of Chinese investments in the EU Member States were identified. The article elucidates current tendencies of development of economic cooperation of China with the world countries, strengthening of which is considered as a result of increasing competitiveness of the PRC. The main directions of cooperation, their advantages and disadvantages, as well as possible future prospects were considered. It has been determined that foreign trade and investment activities of the country will be noticeable in the world because of their scale and intensity. The instruments for ensuring the economic influence of China have been disclosed.

  18. Detection of nonlinear crustal movements using global positioning system

    Science.gov (United States)

    Jiang, Yan

    The Global Positioning System (GPS) is widely used for measuring crustal movements from varieties of geophysical origins. Nonlinear movement in the observations draws increasing attention owing to the improved measurement precision. We developed an innovative method capable of detecting nonlinear motion from the observation time series. By implementing this new technique, we identified several nonlinear episodic events in the noisy time series that were ignored previously. Two types of nonlinear motion with different mechanisms were presented in this dissertation. In Greenland, the nonlinear motion is presented by accelerating uplift in the vertical GPS time series. The accelerating uplift of the continental crust is caused by accelerating melting of the ice cap near the stations. Another form of nonlinear motion expressed by the slow slip events usually last for several weeks. The displacements in the time series are caused by slow reverse movement to the plate convergence direction on the subduction fault plane. We identified a series of such events in Costa Rica and modeled the surface displacement data. We conclude that the slow slip events in this area will release seismic energy accumulated on the fault plane in a nondestructive way, thus reduce the seismic hazards in Costa Rica.

  19. Determination of global positioning system (GPS) receiver clock errors: impact on positioning accuracy

    International Nuclear Information System (INIS)

    Yeh, Ta-Kang; Hwang, Cheinway; Xu, Guochang; Wang, Chuan-Sheng; Lee, Chien-Chih

    2009-01-01

    Enhancing the positioning precision is the primary pursuit of global positioning system (GPS) users. To achieve this goal, most studies have focused on the relationship between GPS receiver clock errors and GPS positioning precision. This study utilizes undifferentiated phase data to calculate GPS clock errors and to compare with the frequency of cesium clock directly, to verify estimated clock errors by the method used in this paper. The frequency stability calculated from this paper (the indirect method) and measured from the National Standard Time and Frequency Laboratory (NSTFL) of Taiwan (the direct method) match to 1.5 × 10 −12 (the value from this study was smaller than that from NSTFL), suggesting that the proposed technique has reached a certain level of quality. The built-in quartz clocks in the GPS receivers yield relative frequency offsets that are 3–4 orders higher than those of rubidium clocks. The frequency stability of the quartz clocks is on average two orders worse than that of the rubidium clock. Using the rubidium clock instead of the quartz clock, the horizontal and vertical positioning accuracies were improved by 26–78% (0.6–3.6 mm) and 20–34% (1.3–3.0 mm), respectively, for a short baseline. These improvements are 7–25% (0.3–1.7 mm) and 11% (1.7 mm) for a long baseline. Our experiments show that the frequency stability of the clock, rather than relative frequency offset, is the governing factor of positioning accuracy

  20. Development of the Kinematic Global Positioning System Precise Point Positioning Method Using 3-Pass Filter

    Directory of Open Access Journals (Sweden)

    Byung-Kyu Choi

    2012-09-01

    Full Text Available Kinematic global positioning system precise point positioning (GPS PPP technology is widely used to the several area such as monitoring of crustal movement and precise orbit determination (POD using the dual-frequency GPS observations. In this study we developed a kinematic PPP technology and applied 3-pass (forward/backward/forward filter for the stabilization of the initial state of the parameters to be estimated. For verification of results, we obtained GPS data sets from six international GPS reference stations (ALGO, AMC2, BJFS, GRAZ, IENG and TSKB and processed in daily basis by using the developed software. As a result, the mean position errors by kinematic PPP showed 0.51 cm in the east-west direction, 0.31 cm in the north-south direction and 1.02 cm in the up-down direction. The root mean square values produced from them were 1.59 cm for the east-west component, 1.26 cm for the south-west component and 2.95 cm for the up-down component.

  1. RDEL: Restart Differential Evolution algorithm with Local Search Mutation for global numerical optimization

    Directory of Open Access Journals (Sweden)

    Ali Wagdy Mohamed

    2014-11-01

    Full Text Available In this paper, a novel version of Differential Evolution (DE algorithm based on a couple of local search mutation and a restart mechanism for solving global numerical optimization problems over continuous space is presented. The proposed algorithm is named as Restart Differential Evolution algorithm with Local Search Mutation (RDEL. In RDEL, inspired by Particle Swarm Optimization (PSO, a novel local mutation rule based on the position of the best and the worst individuals among the entire population of a particular generation is introduced. The novel local mutation scheme is joined with the basic mutation rule through a linear decreasing function. The proposed local mutation scheme is proven to enhance local search tendency of the basic DE and speed up the convergence. Furthermore, a restart mechanism based on random mutation scheme and a modified Breeder Genetic Algorithm (BGA mutation scheme is combined to avoid stagnation and/or premature convergence. Additionally, an exponent increased crossover probability rule and a uniform scaling factors of DE are introduced to promote the diversity of the population and to improve the search process, respectively. The performance of RDEL is investigated and compared with basic differential evolution, and state-of-the-art parameter adaptive differential evolution variants. It is discovered that the proposed modifications significantly improve the performance of DE in terms of quality of solution, efficiency and robustness.

  2. Chocolate agar, a differential medium for gram-positive cocci.

    OpenAIRE

    Gunn, B A

    1984-01-01

    Reactions incurred on chocolate agar by gram-positive cocci were correlated with species identity. Darkening and clearing of the medium was usually associated with the species Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus simulans, and Streptococcus faecalis. Yellowing of chocolate agar was associated with alpha-hemolytic species of Streptococcus. The study demonstrated that reactions occurring on chocolate agar are useful in identifying gram-positive cocci.

  3. Global organization of a positive-strand RNA virus genome.

    Directory of Open Access Journals (Sweden)

    Baodong Wu

    Full Text Available The genomes of plus-strand RNA viruses contain many regulatory sequences and structures that direct different viral processes. The traditional view of these RNA elements are as local structures present in non-coding regions. However, this view is changing due to the discovery of regulatory elements in coding regions and functional long-range intra-genomic base pairing interactions. The ∼4.8 kb long RNA genome of the tombusvirus tomato bushy stunt virus (TBSV contains these types of structural features, including six different functional long-distance interactions. We hypothesized that to achieve these multiple interactions this viral genome must utilize a large-scale organizational strategy and, accordingly, we sought to assess the global conformation of the entire TBSV genome. Atomic force micrographs of the genome indicated a mostly condensed structure composed of interconnected protrusions extending from a central hub. This configuration was consistent with the genomic secondary structure model generated using high-throughput selective 2'-hydroxyl acylation analysed by primer extension (i.e. SHAPE, which predicted different sized RNA domains originating from a central region. Known RNA elements were identified in both domain and inter-domain regions, and novel structural features were predicted and functionally confirmed. Interestingly, only two of the six long-range interactions known to form were present in the structural model. However, for those interactions that did not form, complementary partner sequences were positioned relatively close to each other in the structure, suggesting that the secondary structure level of viral genome structure could provide a basic scaffold for the formation of different long-range interactions. The higher-order structural model for the TBSV RNA genome provides a snapshot of the complex framework that allows multiple functional components to operate in concert within a confined context.

  4. The global position of the U S forest products industry

    Science.gov (United States)

    Jeffrey P. Prestemon; David N. Wear; Michaela O. Foster

    2015-01-01

    The United States’ share of global industrial roundwood production has declined since the 1990s. We reviewed data from 1961-2013 to evaluate the extent of this decline for industrial roundwood and derived secondary forest products compared to other major producing countries. We find that the U.S. global share of industrial roundwood peaked at 28 percent in 1999 but...

  5. Design studies for a technology assessment receiver for global positioning system

    Science.gov (United States)

    Painter, J. H.

    1981-01-01

    The operational conditions of a radio receiver - microprocessor for the global positioning system are studied. Navigation fundamentals and orbit characterization are reviewed. The global positioning system is described with emphasis upon signal structure and satellite positioning. Ranging and receiver processing techniques are discussed.

  6. Globalization, differentiation and drinking cultures, an anthropological perspective

    Directory of Open Access Journals (Sweden)

    Thomas Wilson

    2004-12-01

    Full Text Available L’alcool et sa consommation ne renvoient pas simplement au domaine économique. L’alcool est devenu aujourd’hui une partie intégrale des relations sociales dans différentes cultures au point où son importance globale est souvent sous-estimée par ses plus ardents critiques. En dépit de ses conséquences directes sur la santé, sa consommation a pris une certaine ampleur dans le monde industriel développé. Certainement son rôle central dans la construction des identités individuelles explique sa position clé au sein des sociétés. Que nous dit le saké à propos du Japon ou le vin de Bourgogne sur la France? Que nous dit la consommation ou l’abstinence d’alcool sur les questions d’identité individuelle, d’ethnicité, de classe et de culture? Quelle place tient l’alcool dans la définition de soi et dans la notion de résistance? Répondre à ces questions et à d’autres est le but essentiel de cet article qui examine la consommation d’alcool à travers différentes cultures et ce que boire signifie pour ceux qui choisissent de consommer ou de s’abstenir. De l’Irlande à Hong-Kong, Mexico à l’Allemagne, l’alcool occupe un certain nombre de fonctions sociales, religieuses, politiques et familiales. Les cultures du boire définissent ces consommations dans le cadre plus large des pratiques sociales et montrent comment classes sociales, ethnicité et nationalisme peuvent s’exprimer à travers cette commodité. En partant d’approches de terrain, les contributeurs analysent l’interface entre culture et pouvoir dans les bars et pubs, la signification des images publicitaires, le rôle de ces boissons dans la vie quotidienne. Le résultat est la première publication comparative sur les questions de l’impact que la consommation d’alcool a sur l’identité nationale dans le monde aujourd’hui.Alcohol is not only big business, it has become an essential part of social relations in so many cultures that

  7. Positive biodiversity-productivity relationship predominant in global forests

    NARCIS (Netherlands)

    Liang, Jingjing; Crowther, Thomas W.; Picard, Nicolas; Wiser, Susan; Zhou, Mo; Alberti, Giorgio; Schulze, Ernst-Detlef; McGuire, A. David; Bozzato, Fabio; Pretzsch, Hans; de-Miguel, Sergio; Paquette, Alain; Hérault, Bruno; Scherer-Lorenzen, Michael; Barrett, Christopher B.; Glick, Henry B.; Hengeveld, Geerten M.; Nabuurs, Gert-Jan; Pfautsch, Sebastian; Viana, Helder; Vibrans, Alexander C.; Ammer, Christian; Schall, Peter; Verbyla, David; Tchebakova, Nadja; Fischer, Markus; Watson, James V.; Chen, Han Y. H.; Lei, Xiangdong; Schelhaas, Mart-Jan; Lu, Huicui; Gianelle, Damiano; Parfenova, Elena I.; Salas, Christian; Lee, Eungul; Lee, Boknam; Kim, Hyun Seok; Bruelheide, Helge; Coomes, David A.; Piotto, Daniel; Sunderland, Terry; Schmid, Bernhard; Gourlet-Fleury, Sylvie; Sonké, Bonaventure; Tavani, Rebecca; Zhu, Jun; Brandl, Susanne; Vayreda, Jordi; Kitahara, Fumiaki; Searle, Eric B.; Neldner, Victor J.; Ngugi, Michael R.; Baraloto, Christopher; Frizzera, Lorenzo; Bałazy, Radomir; Oleksyn, Jacek; Zawiła-Niedźwiecki, Tomasz; Bouriaud, Olivier; Bussotti, Filippo; Finér, Leena; Jaroszewicz, Bogdan; Jucker, Tommaso; Valladares, Fernando; Jagodzinski, Andrzej M.; Peri, Pablo L.; Gonmadje, Christelle; Marthy, William; O’Brien, Timothy; Martin, Emanuel H.; Marshall, Andrew R.; Rovero, Francesco; Bitariho, Robert; Niklaus, Pascal A.; Alvarez-Loayza, Patricia; Chamuya, Nurdin; Valencia, Renato; Mortier, Frédéric; Wortel, Verginia; Engone-Obiang, Nestor L.; Ferreira, Leandro V.; Odeke, David E.; Vasquez, Rodolfo M.; Lewis, Simon L.; Reich, Peter B.

    2016-01-01

    The biodiversity-productivity relationship (BPR) is foundational to our understanding of the global extinction crisis and its impacts on ecosystem functioning. Understanding BPR is critical for the accurate valuation and effective conservation of biodiversity. Using ground-sourced data from 777,126

  8. A theoretical ovary position in link with the global anatomical ...

    African Journals Online (AJOL)

    This typical position is submitted to some change during the first pregnancy after which the ovary becomes slightly displaced and probably never again returns to its original position. Generally the ovary moves forward and probably with slight descent and loss of erect posture: in fact the broad ligament may remain enlarged ...

  9. Mapping stream habitats with a global positioning system: Accuracy, precision, and comparison with traditional methods

    Science.gov (United States)

    Dauwalter, D.C.; Fisher, W.L.; Belt, K.C.

    2006-01-01

    We tested the precision and accuracy of the Trimble GeoXT??? global positioning system (GPS) handheld receiver on point and area features and compared estimates of stream habitat dimensions (e.g., lengths and areas of riffles and pools) that were made in three different Oklahoma streams using the GPS receiver and a tape measure. The precision of differentially corrected GPS (DGPS) points was not affected by the number of GPS position fixes (i.e., geographic location estimates) averaged per DGPS point. Horizontal error of points ranged from 0.03 to 2.77 m and did not differ with the number of position fixes per point. The error of area measurements ranged from 0.1% to 110.1% but decreased as the area increased. Again, error was independent of the number of position fixes averaged per polygon corner. The estimates of habitat lengths, widths, and areas did not differ when measured using two methods of data collection (GPS and a tape measure), nor did the differences among methods change at three stream sites with contrasting morphologies. Measuring features with a GPS receiver was up to 3.3 times faster on average than using a tape measure, although signal interference from high streambanks or overhanging vegetation occasionally limited satellite signal availability and prolonged measurements with a GPS receiver. There were also no differences in precision of habitat dimensions when mapped using a continuous versus a position fix average GPS data collection method. Despite there being some disadvantages to using the GPS in stream habitat studies, measuring stream habitats with a GPS resulted in spatially referenced data that allowed the assessment of relative habitat position and changes in habitats over time, and was often faster than using a tape measure. For most spatial scales of interest, the precision and accuracy of DGPS data are adequate and have logistical advantages when compared to traditional methods of measurement. ?? 2006 Springer Science+Business Media

  10. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

    OpenAIRE

    Kang, Jong-Sun; Mulieri, Philip J.; Hu, Yulan; Taliana, Lavinia; Krauss, Robert S.

    2002-01-01

    CDO is a cell surface receptor-like protein that positively regulates myogenic differentiation. Reported here is the identification of BOC, which, with CDO, defines a newly recognized subfamily within the immunoglobulin superfamily. cdo and boc are co-expressed in muscle precursors in the developing mouse embryo. Like CDO, BOC accelerates differentiation of cultured myoblast cell lines and participates in a positive feedback loop with the myogenic transcription factor, MyoD. CDO and BOC form ...

  11. Differential returns from globalization to women smallholder coffee ...

    African Journals Online (AJOL)

    Background: Globalization-related measures to liberalize trade and stimulate export production were applied in Uganda in the late 1980s, including in the coffee production sector, to revitalize agricultural production, increase incomes to farmers and improve rural food security. Objective: To explore the different effects of ...

  12. Nonlinear initial-value problems with positive global solutions

    Directory of Open Access Journals (Sweden)

    John V. Baxley

    2003-02-01

    Full Text Available We give conditions on $m(t$, $p(t$, and $f(t,y,z$ so that the nonlinear initial-value problem {gather*} frac{1}{m(t} (p(ty'' + f(t,y,p(ty' = 0,quadmbox{for }t>0, y(0=0,quad lim_{t o 0^+} p(ty'(t = B, end{gather*} has at least one positive solution for all $t>0$, when $B$ is a sufficiently small positive constant. We allow a singularity at $t=0$ so the solution $y'(t$ may be unbounded near $t=0$.

  13. An integral, positive psychology paradigm for global coherence ...

    African Journals Online (AJOL)

    The article reviews research evidence in relation to psychophysiological coherence, which is characterised by a heart rhythm pattern of elevated amplitude in low frequency heart rate variability of around 0.1 Hz. This is associated with synchronisation between various physiological systems, positive emotions, athletes' ...

  14. The use of Global Positioning System (GPS) tracking devices to ...

    African Journals Online (AJOL)

    The intermittent nature of Under-19 rugby union match play, as well as the unique roles and requirements of positional groups, were confirmed. ... of collisions experienced by players, can assist coaches with planning specific training programmes, as well as adequate recovery between training sessions and games.

  15. Brand Positioning Through Advertising in Asia, North America, and Europe : The Role of Global Consumer Culture

    NARCIS (Netherlands)

    Alden, D.L.; Steenkamp, J.E.B.M.; Batra, R.

    1999-01-01

    In this study, the authors examine the emergence of brand positioning strategies in advertising that parallel the growth of the global marketplace. A new construct, global consumer culture positioning (GCCP), is proposed, operationalized, and tested. This construct associates the brand with a widely

  16. 75 FR 2581 - Eighty-First Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2010-01-15

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held February 2-5, 2010, from 9 a.m. to 4:30 p.m. (unless stated...

  17. 76 FR 27744 - Eighty-Fifth Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2011-05-12

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held May 26, 2011, from 9 a.m. to 11:45 a.m. ADDRESSES: The...

  18. 76 FR 67019 - Eighty-Seventh: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2011-10-28

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), U.S... System (GPS). SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 159: Global Positioning System (GPS) 87th meeting. DATES: The meeting will be held November 14-18...

  19. 76 FR 33022 - Eighty-Sixth Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2011-06-07

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held June 13-17, 2011, from 9 a.m. to 4:30 p.m. ADDRESSES: The...

  20. 76 FR 35858 - Global Positioning System Directorate (GPSD); Notice of Meeting

    Science.gov (United States)

    2011-06-20

    ... DEPARTMENT OF DEFENSE Department of the Air Force Global Positioning System Directorate (GPSD); Notice of Meeting ACTION: Notice of Meeting--Public Interface Control Working Group (ICWG) for Signals-in... notice informs the public that the Global Positioning Systems Directorate (GPSD) will be hosting a Public...

  1. 75 FR 14658 - Invitation for Public Comment on Mitigation Options for Global Positioning System Satellite...

    Science.gov (United States)

    2010-03-26

    ... Public Comment on Mitigation Options for Global Positioning System Satellite Vehicle Number 49 AGENCY... options prior to changing the health status of Global Positioning System (GPS) satellite IIR-20M (satellite vehicle number 49--SVN 49) from unhealthy to healthy. The potential mitigations are each designed...

  2. Global Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions

    Science.gov (United States)

    2016-12-01

    Award Number: W81XWH-11-2-0175 TITLE: Global Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions PRINCIPAL...sophisticated Global Positioning Systems (GPS) technology of isolated viruses and genetic characterization, spatial and temporal analysis are being...REPORT DATE December 2016 2. REPORT TYPE Final 3. DATES COVERED 27 Sept 2011 - 26 Sept 2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Global

  3. ROMANIAN BUSINESS POSITION ON THE CONTEMPORARY GLOBALIZATION CHESSBOARD

    Directory of Open Access Journals (Sweden)

    Aurica Grec

    2012-01-01

    Full Text Available Given that from the global hat appear, one by one, new dangers, threats and risks which are destabilizing market forces, nowadays we’re seeing a pattern with non-predictable EFS (economic, financial, social indicators. In this context, appear new paradoxes, so as the states desired to achieve a better and more sustainable networking, they found that such reaction generate, on the domino principle, other countries security. We refer here both to the military and security side and to the non military one, in order to underline the dimensions of the LRI (local, regional, international scenarios. They are becoming more complicated and also are fighting with lack of vision for to identify, in real time, the ways to counter the micro-macro effects on the current organizational level.

  4. Deconstructing Positive Affect in Later Life: A Differential Functionalist Analysis of Joy and Interest

    Science.gov (United States)

    Consedine, Nathan S.; Magai, Carol; King, Arlene R.

    2004-01-01

    Positive affect, an index of psychological well-being, is a known predictor of functionality and health in later life. Measures typically studied include joy, happiness, and subjective well-being, but less often interest--a positive emotion with functional properties that differ from joy or happiness. Following differential emotions theory, the…

  5. Efficacy of direct Gram stain in differentiating staphylococci from streptococci in blood cultures positive for gram-positive cocci.

    Science.gov (United States)

    Agger, W A; Maki, D G

    1978-01-01

    A preponderance of clusters seen on direct Gram stain of blood cultures positive for gram-positive cocci was 98% sensitive and 100% specific for identification of staphylococcal species or of Peptococcus. A preponderance of chains, pairs, or both was 100% sensitive and 98% specific for identifying streptococci. Further presumptive identification of either staphylococci or streptococci based on microscopic morphology was unreliable. The direct Gram stain is highly reliable for differentiating staphylococci from streptococci and should be of considerable value to clinicians selecting initial antimicrobial therapy. PMID:75888

  6. Global Positioning System: Observations on Quarterly Reports from the Air Force

    Science.gov (United States)

    2016-10-17

    Positioning System: Observations on Quarterly Reports from the Air Force The satellite-based Global Positioning System (GPS) provides positioning, navigation...Page 1 GAO-17-162R GPS Quarterly Reports 441 G St. N.W. Washington, DC 20548 October 17, 2016 Congressional Committees Global ...infrastructure, and transportation safety. The Department of Defense (DOD)—specifically, the Air Force—develops and operates the GPS system, which

  7. Topics in differential geometry associated with position vector fields on Euclidean submanifolds

    Directory of Open Access Journals (Sweden)

    Bang-Yen Chen

    2017-01-01

    Full Text Available The position vector field is the most elementary and natural geometric object on a Euclidean submanifold. The purpose of this article is to survey six research topics in differential geometry in which the position vector field plays very important roles. In this article we also explain the relationship between position vector fields and mechanics, dynamics, and D’Arcy Thompson’s law of natural growth in biology.

  8. Global analysis of differential expressed genes in ECV304 ...

    African Journals Online (AJOL)

    EB

    alternatively known as human herpesvirus-5 (HHV-. 5), is the most common pathogen causing congenital infection and primary infection during pregnancy1. It can cause .... calculated the centroid positions of each spot on the microarray. The Cookie Cutter method was used to define the features. Filtering was automatically.

  9. Assessment of EU member states' positions in Global Value Chains

    Directory of Open Access Journals (Sweden)

    Ines KERSAN-SKABIĆ

    2017-12-01

    Full Text Available The participation of countries in GVCs can be measured in different ways; most commonly by using the GVC participation index and the GVC position index. The research is focused on the analysis of GVC participation of EU member states applying different indicators and comparing the characteristics of three groups of EU member states (EU core members, EU Southern members and EU new member states. We have applied statistical analysis on the TiVA database. The results indicate a high level of participation of EU member states in GVCs with a predominance of backward linkages. Luxembourg, Slovakia and Hungary have the highest levels of participation while Croatia has the lowest participation. EU member states are very integrated and intra-regional, so about 80% of value added in their gross export or final demand originates from the EU (domestic value added or value added from other member states.

  10. Ring positional differentiation of isomeric N-alkylated fluorocathinones by gas chromatography/tandem mass spectrometry.

    Science.gov (United States)

    Westphal, Folker; Junge, Thomas

    2012-11-30

    In analogy to our previously published procedure for the differentiation of regioisomeric fluoroamphetamines a method was developed, to differentiate ring positional isomeric fluorocathinones by product ion spectrometry of ions generated by chemical ionization (CI) under GC-MS conditions using methane as reagent gas. N-alkylated ortho-, meta- and para-fluorocathinones could be unequivocally differentiated by product ion spectrometry of the hydrogen fluoride loss ions [M+H-HF](+) using a triple quadrupole mass spectrometer with argon as collision gas under normalized collision conditions. This method enables the differentiation of ring positional isomers of fluorocathinones even in complex mixtures and low concentrations. The applicability of the method was shown by the analysis of synthesized N-alkylated ortho-, meta- and para-fluorocathinones and seized designer drug mixtures. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  11. On the Asymptotic Behavior of Positive Solutions of Certain Fractional Differential Equations

    Directory of Open Access Journals (Sweden)

    Said R. Grace

    2015-01-01

    Full Text Available This paper deals with the asymptotic behavior of positive solutions of certain forced fractional differential equations of the form DcαCyt=et+ft, xt, c>1, α∈0,1, where yt=atx′t′, c0=y(c/Γ(1 =yc, and c0 is a real constant. From the obtained results, we derive a technique which can be applied to some related fractional differential equations.

  12. Approximating positive solutions of nonlinear first order ordinary quadratic differential equations

    Directory of Open Access Journals (Sweden)

    Bapurao C. Dhage

    2015-12-01

    Full Text Available In this paper, the authors prove the existence as well as approximations of the positive solutions for an initial value problem of first-order ordinary nonlinear quadratic differential equations. An algorithm for the solutions is developed and it is shown that the sequence of successive approximations converges monotonically to the positive solution of related quadratic differential equations under some suitable mixed hybrid conditions. We base our results on the Dhage iteration method embodied in a recent hybrid fixed-point theorem of Dhage (2014 in partially ordered normed linear spaces. An example is also provided to illustrate the abstract theory developed in the paper.

  13. Dhage Iteration Method for Approximating Positive Solutions of PBVPs of Nonlinear Quadratic Differential Equations with Maxima

    Directory of Open Access Journals (Sweden)

    Shyam B. Dhage

    2016-03-01

    Full Text Available In this paper authors prove the existence as well as approximation of the positive solutions for a periodic boundary value problem of first order ordinary nonlinear quadratic differential equations with maxima. An algorithm for the solutions is developed and it is shown that certain sequence of successive approximations converges monotonically to the positive solution of considered quadratic differential equations under some suitable mixed hybrid conditions. Our results rely on the Dhage iteration principle embodied in a recent hybrid fixed point theorem of Dhage (2014. A numerical example is also provided to illustrate the hypotheses and abstract theory developed in this paper.

  14. Global collective dose commitments from release of long-lived radionuclides. Differential cost-benefit considerations

    International Nuclear Information System (INIS)

    Gjoerup, H.L.

    1977-01-01

    The concept of global collective dose commitment as a measure of total detriment from the release of radioactivity to the environment is outlined. Estimates are given of global collective dose commitments resulting from the release of 14 C and uranium daughter products from the nuclear fuel cycle. Comparisons are made with similar estimates of global collective dose commitments resulting from the use of fossil fuels and certain fertilizers due to their content of uranium and its daughter products. In the case of long-lived radionuclides that remain in circulation in the biosphere, it is shown that the use of global collective dose commitments in differential cost-benefit analysis can lead to questionable results. In differential cost-benefit analysis it is suggested that population exposures should not simply be integrated irrespective of their time of occurrence, but that a certain discount rate should be applied for future doses. This suggestion is examined. (author)

  15. Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW) data set measures atmospheric water vapor using ground-based...

  16. For Want of a Nail: An Assessment of Global Positioning System Satellite Replenishment

    Science.gov (United States)

    2004-05-26

    form calls for more action, not 225 Chris Phoenix and Mike Treder , "Applying the Precautionary...Capt Mike. Navstar Global Positioning System CSAT. Presentation to CSAT at Vandenberg AFB, CA, 19 November 2003. Phoenix, Chris, and Mike Treder

  17. Global Positioning System (GPS) civil signal monitoring (CSM) trade study report

    Science.gov (United States)

    2014-03-07

    This GPS Civil Signal Monitoring (CSM) Trade Study has been performed at the direction of DOT/FAA Navigation Programs as the agency of reference for consolidating civil monitoring requirements on the Global Positioning System (GPS). The objective of ...

  18. Sustaining Air Force Space Systems: A Model for the Global Positioning System

    National Research Council Canada - National Science Library

    Snyder, Don; Mills, Patrick; Comanor, Katherine; Roll, Jr, Charles R

    2007-01-01

    ... and sustainment affect the performance of space systems. In this monograph, we develop a pilot framework for analyzing these and related questions in the ground segment of the Global Positioning System and recommend steps for implementing this framework...

  19. MDOT implementation plan for global positioning systems (GPS) technology in planning, design, and construction delivery.

    Science.gov (United States)

    2010-09-13

    Global Positioning System (GPS) technology offers advantages to transportation agencies in the planning, design and construction stages of project delivery. This research study will develop a guide for Mississippi Department of Transportation (MDOT) ...

  20. Positive feedback between global warming and atmospheric CO2 concentration inferred from past climate change

    NARCIS (Netherlands)

    Scheffer, M.; Brovkin, V.; Cox, P.M.

    2006-01-01

    There is good evidence that higher global temperatures will promote a rise of greenhouse gas levels, implying a positive feedback which will increase the effect of anthropogenic emissions on global temperatures. However, the magnitude of this effect predicted by the available models remains highly

  1. Harmonic oscillator thermal density matrix: First-order differential equations for the position representation

    Science.gov (United States)

    Barragán-Gil, L. F.; Walser, R.

    2018-01-01

    A first-order partial differential equation is derived whose solution enables us to find straightforwardly the off-diagonal matrix elements in the position representation of the harmonic oscillator density operator. This approach constitutes an alternative to techniques that require advanced knowledge of mathematical and quantum mechanical results.

  2. Computing solutions of the modified Bessel differential equation for imaginary orders and positive arguments

    NARCIS (Netherlands)

    A. Gil (Amparo); J. Segura (Javier); N.M. Temme (Nico)

    2004-01-01

    textabstractWe describe a variety of methods to compute the functions Kia (x), Lia (x) and their derivatives for real a and positive x. These functions are numerically satisfactory independent solutions of the differential equation x2w'' + xw' + (a2

  3. Positive solutions of multi-point boundary value problem of fractional differential equation

    Directory of Open Access Journals (Sweden)

    De-xiang Ma

    2015-07-01

    Full Text Available By means of two fixed-point theorems on a cone in Banach spaces, some existence and multiplicity results of positive solutions of a nonlinear fractional differential equation boundary value problem are obtained. The proofs are based upon some properties of Green’s function, which are also the key of the paper.

  4. Relating Specific Emotions to Intrinsic Motivation: On the Moderating Role of Positive and Negative Emotion Differentiation

    Science.gov (United States)

    Vandercammen, Leen; Hofmans, Joeri; Theuns, Peter

    2014-01-01

    Despite the fact that studies on self-determination theory have traditionally disregarded the explicit role of emotions in the motivation eliciting process, research attention for the affective antecedents of motivation is growing. We add to this emerging research field by testing the moderating role of emotion differentiation –individual differences in the extent to which people can differentiate between specific emotions– on the relationship between twelve specific emotions and intrinsic motivation. To this end, we conducted a daily diary study (N = 72) and an experience sampling study (N = 34). Results showed that the relationship between enthusiasm, cheerfulness, optimism, contentedness, gloominess, miserableness, uneasiness (in both studies 1 and 2), calmness, relaxation, tenseness, depression, worry (only in Study 1) on one hand and intrinsic motivation on the other hand was moderated by positive emotion differentiation for the positive emotions and by negative emotion differentiation for the negative emotions. Altogether, these findings suggest that for people who are unable to distinguish between different specific positive emotions the relationship between those specific positive emotions and intrinsic motivation is stronger, whereas the relationship between specific negative emotions and intrinsic motivation is weaker for people who are able to distinguish between the different specific negative emotions. Theoretical and practical implications are discussed. PMID:25517984

  5. Triple positive  solutions of nth order impulsive integro-differential equations

    Directory of Open Access Journals (Sweden)

    Zeyong Qiu

    2011-07-01

    Full Text Available In this paper, we prove the existence of at least three positive solutions of boundary value problems for nth order nonlinear impulsive integro-differential equations of mixed type on infinite interval with infinite number of impulsive times. Our results are obtained by applying a new fixed point theorem introduced by Avery and Peterson.

  6. Multiple Positive Periodic Solutions for Functional Differential Equations with Impulses and a Parameter

    Directory of Open Access Journals (Sweden)

    Zhenguo Luo

    2014-01-01

    Full Text Available We apply the Krasnoselskii fixed-point theorem to investigate the existence of multiple positive periodic solutions for a class of impulsive functional differential equations with a parameter; some verifiable sufficient results are established easily. In particular, our results extend and improve some previous results.

  7. Positive Solutions for System of Nonlinear Fractional Differential Equations in Two Dimensions with Delay

    Directory of Open Access Journals (Sweden)

    Azizollah Babakhani

    2010-01-01

    Full Text Available We investigate the existence and uniqueness of positive solution for system of nonlinear fractional differential equations in two dimensions with delay. Our analysis relies on a nonlinear alternative of Leray-Schauder type and Krasnoselskii's fixed point theorem in a cone.

  8. Differential Language Functioning of Monolinguals and Bilinguals on Positive-Negative Emotional Expression

    Science.gov (United States)

    Kheirzadeh, Shiela; Hajiabed, Mohammadreza

    2016-01-01

    The present interdisciplinary research investigates the differential emotional expression between Persian monolinguals and Persian-English bilinguals. In other words, the article was an attempt to answer the questions whether bilinguals and monolinguals differ in the expression of positive and negative emotions elicited through sad and happy…

  9. Relating specific emotions to intrinsic motivation: on the moderating role of positive and negative emotion differentiation.

    Science.gov (United States)

    Vandercammen, Leen; Hofmans, Joeri; Theuns, Peter

    2014-01-01

    Despite the fact that studies on self-determination theory have traditionally disregarded the explicit role of emotions in the motivation eliciting process, research attention for the affective antecedents of motivation is growing. We add to this emerging research field by testing the moderating role of emotion differentiation -individual differences in the extent to which people can differentiate between specific emotions- on the relationship between twelve specific emotions and intrinsic motivation. To this end, we conducted a daily diary study (N = 72) and an experience sampling study (N = 34). Results showed that the relationship between enthusiasm, cheerfulness, optimism, contentedness, gloominess, miserableness, uneasiness (in both studies 1 and 2), calmness, relaxation, tenseness, depression, worry (only in Study 1) on one hand and intrinsic motivation on the other hand was moderated by positive emotion differentiation for the positive emotions and by negative emotion differentiation for the negative emotions. Altogether, these findings suggest that for people who are unable to distinguish between different specific positive emotions the relationship between those specific positive emotions and intrinsic motivation is stronger, whereas the relationship between specific negative emotions and intrinsic motivation is weaker for people who are able to distinguish between the different specific negative emotions. Theoretical and practical implications are discussed.

  10. Global markets and the differential effects of climate and weather on conflict

    Science.gov (United States)

    Meng, K. C.; Hsiang, S. M.; Cane, M. A.

    2011-12-01

    Both climate and weather have been attributed historically as possible drivers for violence. Previous empirical studies have either focused on isolating local idiosyncratic weather variation or have conflated weather with spatially coherent climatic changes. This paper provides the first study of the differential impacts of climate and weather variation by employing methods developed in earlier work linking the El Nino Southern Oscillation (ENSO) with the onset of civil conflicts. By separating the effects of climate from local weather, we are able to test possible mechanisms by which atmospheric changes can cause violence. It is generally difficult to separate the effect of year-to-year climate variations from other global events that might drive conflict. We avoid this problem by examining the set of tropical countries that are strongly teleconnected to ENSO. For this region, the ENSO cycle parallels the common year-to-year pattern of violence. Using ENSO, we isolate the influence of climatic changes from other global determinants of violence and compare it with the effect of local weather variations. We find that while climate affects the onset of civil conflicts in teleconnected countries, local weather has no significant effect. Productivity overall as well as across major sectors is more affected by local weather than by climatic variation. This is particularly evident in the agricultural sector where total value and cereal yield decline much greater from a 1°C increase in local temperature than a 1°C increase in ENSO. However, when examining the effect on food prices, we find that ENSO is associated with a large and statistically significant increase in cereal prices but no effect from hotter local temperatures. Altogether, this evidence points toward the ability of global and regional commodity markets to insure against the effects of local weather variation and their limitations in containing losses from aggregate shocks such as El Nino events. We posit

  11. Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis.

    Science.gov (United States)

    Hou, Bingbing; Tao, Liyuan; Zhu, Xiaoyu; Wu, Wei; Guo, Meijin; Ye, Jiang; Wu, Haizhen; Zhang, Huizhan

    2018-03-17

    Global regulator BldA, the only tRNA for a rare leucine codon UUA, is best known for its ability to affect morphological differentiation and secondary metabolism in the genus Streptomyces. In this study, we confirmed the regulatory function of the bldA gene (Genbank accession no. EU124663.1) in Streptomyces lincolnensis. Disruption of bldA hinders the sporulation and lincomycin production, that can recur when complemented with a functional bldA gene. Western blotting assays demonstrate that translation of the lmbB2 gene which encodes a L-tyrosine hydroxylase is absolutely dependent on BldA; however, mistranslation of the lmbU gene which encodes a cluster-situated regulator (CSR) is observed in a bldA mutant. Intriguingly, when the preferential cognate codon CTG was used, the expression level of LmbU was not the highest compared to the usage of rare codon TTA or CTA, indicating the rare codon in this position is significant for the regulation of lmbU expression. Moreover, replacement of TTA codons in both genes with another leucin codon in the bldA mutant did not restore lincomycin production. Thus, we believe that the bldA gene regulates lincomycin production via controlling the translation of not only lmbB2 and lmbU, but also the other TTA-containing genes. In conclusion, the present study demonstrated the importance of the bldA gene in morphological differentiation and lincomycin production in S. lincolnensis.

  12. BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation.

    Directory of Open Access Journals (Sweden)

    Takashi Matsumoto

    Full Text Available Bone morphogenetic proteins (BMPs regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development. Among them, BMP-2, one of the most potent osteogenic signaling molecules, stimulates osteoblast differentiation, while it inhibits myogenic differentiation in C2C12 cells. To evaluate genes involved in BMP-2-induced osteoblast differentiation, we performed cDNA microarray analyses to compare BMP-2-treated and -untreated C2C12 cells. We focused on Alx3 (aristaless-like homeobox 3 which was clearly induced during osteoblast differentiation. Alx3, a homeobox gene related to the Drosophilaaristaless gene, has been linked to developmental functions in craniofacial structures and limb development. However, little is known about its direct relationship with bone formation. In the present study, we focused on the mechanisms of Alx3 gene expression and function during osteoblast differentiation induced by BMP-2. In C2C12 cells, BMP-2 induced increase of Alx3 gene expression in both time- and dose-dependent manners through the BMP receptors-mediated SMAD signaling pathway. In addition, silencing of Alx3 by siRNA inhibited osteoblast differentiation induced by BMP-2, as showed by the expressions of alkaline phosphatase (Alp, Osteocalcin, and Osterix, while over-expression of Alx3 enhanced osteoblast differentiation induced by BMP-2. These results indicate that Alx3 expression is enhanced by BMP-2 via the BMP receptors mediated-Smad signaling and that Alx3 is a positive regulator of osteoblast differentiation induced by BMP-2.

  13. Global Uniqueness Results for Fractional Order Partial Hyperbolic Functional Differential Equations

    Directory of Open Access Journals (Sweden)

    Benchohra Mouffak

    2011-01-01

    Full Text Available Abstract We investigate the global existence and uniqueness of solutions for some classes of partial hyperbolic differential equations involving the Caputo fractional derivative with finite and infinite delays. The existence results are obtained by applying some suitable fixed point theorems.

  14. GLOBOX : A spatially differentiated global fate, intake and effect model for toxicity assessment in LCA

    NARCIS (Netherlands)

    Wegener Sleeswijk, Anneke; Heijungs, Reinout

    GLOBOX is a model for the calculation of spatially differentiated LCA toxicity characterisation factors on a global scale. It can also be used for human and environmental risk assessment. The GLOBOX model contains equations for the calculation of fate, intake and effect factors, and equations for

  15. Histologic differentiation and mucin phenotype in white opaque substance-positive gastric neoplasias.

    Science.gov (United States)

    Ueo, Tetsuya; Yonemasu, Hirotoshi; Yao, Kenshi; Ishida, Tetsuya; Togo, Kazumi; Yanai, Yuka; Fukuda, Masahide; Motomura, Mitsuteru; Narita, Ryoich; Murakami, Kazunari

    2015-12-01

    The authors previously reported that the white opaque substance (WOS) in gastric epithelial neoplasia was caused by accumulation of lipid droplets by immunohistochemical and immunoelectron microscopic studies of adipophilin, which was recently identified and validated as a marker of lipid droplets. The aim of the current study was to investigate the characteristics of the histologic differentiation and mucin phenotype in WOS-positive gastric epithelial neoplasias. A total of 130 gastric epithelial neoplasias (45 adenomas and 85 early adenocarcinomas) from 120 patients were retrospectively evaluated. The presence or absence of WOS was evaluated by M-NBI. Lipids were examined by immunohistochemical staining for adipophilin. Tissue phenotypes were immunohistochemically classified as intestinal (I), gastrointestinal (GI), and gastric (G) using antibodies against CD10, MUC2, MUC5AC and MUC6. The histologic differentiation and mucin phenotype of WOS-positive neoplasias were characterized and examined according to adipophilin expression. The presence of WOS by M-NBI was correlated with histologic differences between adenoma or differentiated type adenocarcinoma and mixed type or undifferentiated type adenocarcinoma (P = 0.0153). Adipophilin was only expressed in primary adenoma and well to moderately differentiated adenocarcinoma components but not in undifferentiated components. WOS and adipophilin expression were only observed in neoplasias with I or GI phenotypes, but not in those with the G phenotype (P neoplasias might indicate differentiation into a mature histological subtype with GI or I mucin phenotype.

  16. Contributions of Positive Psychology to Peace: Toward Global Well-Being and Resilience

    Science.gov (United States)

    Cohrs, J. Christopher; Christie, Daniel J.; White, Mathew P.; Das, Chaitali

    2013-01-01

    In this article, we analyze the relationship between positive psychology and peace psychology. We discuss how positive emotions, engagement, meaning, personal well-being, and resilience may impact peace at different levels, ranging from the personal and interpersonal to community, national, and global peace. First, we argue that an…

  17. Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

    International Nuclear Information System (INIS)

    Tsukasaki, Masayuki; Yamada, Atsushi; Suzuki, Dai; Aizawa, Ryo; Miyazono, Agasa; Miyamoto, Yoichi; Suzawa, Tetsuo; Takami, Masamichi; Yoshimura, Kentaro; Morimura, Naoko; Yamamoto, Matsuo; Kamijo, Ryutaro

    2011-01-01

    Highlights: → TNF-α inhibits POEM gene expression. → Inhibition of POEM gene expression is caused by NF-κB activation by TNF-α. → Over-expression of POEM recovers inhibition of osteoblast differentiation by TNF-α. -- Abstract: POEM, also known as nephronectin, is an extracellular matrix protein considered to be a positive regulator of osteoblast differentiation. In the present study, we found that tumor necrosis factor-α (TNF-α), a key regulator of bone matrix properties and composition that also inhibits terminal osteoblast differentiation, strongly inhibited POEM expression in the mouse osteoblastic cell line MC3T3-E1. TNF-α-induced down-regulation of POEM gene expression occurred in both time- and dose-dependent manners through the nuclear factor kappa B (NF-κB) pathway. In addition, expressions of marker genes in differentiated osteoblasts were down-regulated by TNF-α in a manner consistent with our findings for POEM, while over-expression of POEM recovered TNF-α-induced inhibition of osteoblast differentiation. These results suggest that TNF-α inhibits POEM expression through the NF-κB signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-α.

  18. Dynamic tracking performance of indoor global positioning system: An experimental and theoretical study

    Directory of Open Access Journals (Sweden)

    Gang Zhao

    2015-10-01

    Full Text Available The automation level has been improved rapidly with the introduction of large-scale measurement technologies, such as indoor global positioning system, into the production process among the fields of car, ship, and aerospace due to their excellent measurement characteristics. In fact, the objects are usually in motion during the real measurement process; however, the dynamic measurement characteristics of indoor global positioning system are much limited and still in exploration. In this research, we focused on the dynamic tracking performance of indoor global positioning system and then successfully built a mathematical model based on its measurement principles. We first built single and double station system models with the consideration of measurement objects’ movement. Using MATLAB simulation, we realized the dynamic measurement characteristics of indoor global positioning system. In the real measurement process, the experimental results also support the mathematical model that we built, which proves a great success in dynamic measurement characteristics. We envision that this dynamic tracking performance of indoor global positioning system would shed light on the dynamic measurement of a motion object and therefore make contribution to the automation production.

  19. Saint Petersburg as a Global Coastal City: Positioning in the Baltic Region

    Directory of Open Access Journals (Sweden)

    Lachininskii Stanislav

    2015-09-01

    Full Text Available The Baltic region consists of coastal areas of nine countries — Russia, Estonia, Latvia, Lithuania, Poland, Germany, Denmark, Sweden, and Finland. The region’s hubs are the port cities located along the Baltic Sea coast. However, Peter Taylor and Saskia Sassen’s classification identifies higher status cities and ‘global cities’, which are to be considered in the global context. Seven coastal regions are distinguished within this region, whose organising centers are the global coastal cities of Stockholm, Copenhagen, Helsinki, Riga, Tallinn, St. Petersburg, and Malmö. The concept of a “global city-region” (Sassen can be used as a methodological framework for analyzing this connection. Within this hierarchy, the dominant alpha group global city is Stockholm. The authors argue that, as a global coastal city, St. Petersburg forms the St. Petersburg coastal region, which can be defined as a typical "global city region". The index method shows that the position of St. Petersburg in the system of global coastal cities of the Baltic region is relatively favorable in view of its transport, logistics, and demographic potential and the advantageous geo-economic situation. St. Petersburg has certain competitive advantages in the region brought about by its demographic potential, port freight capacity, and the favorable geo-economic position of the "sea gate" of Russia. However, the level of high-tech services and ‘new economy’ development is not sufficient for the port to become a match for the top three cities (Stockholm, Helsinki, and Copenhagen. This is increasingly important because transboundary global city networks demonstrate that global cities are functions of global networks. Saint Petersburg is just starting to integrate into these networks through the Pulkovo airline hub and seaports of Ust-Luga, Primorsk, and Saint Petersburg.

  20. Saint Petersburg as a Global Coastal City: Positioning in the Baltic Region

    Directory of Open Access Journals (Sweden)

    Lachninsky S.

    2015-08-01

    Full Text Available The Baltic region consists of coastal areas of nine countries — Russia, Estonia, Latvia, Lithuania, Poland, Germany, Denmark, Sweden, and Finland. The region’s hubs are the port cities located along the Baltic Sea coast. However, Peter Taylor and Saskia Sassen’s classification identifies higher status cities and ‘global cities’, which are to be considered in the global context. Seven coastal regions are distinguished within this region, whose organising centers are the global coastal cities of Stockholm, Copenhagen, Helsinki, Riga, Tallinn, St. Petersburg, and Malmö. The concept of a “global city-region” (Sassen can be used as a methodological framework for analyzing this connection. Within this hierarchy, the dominant alpha group global city is Stockholm. The authors argue that, as a global coastal city, St. Petersburg forms the St. Petersburg coastal region, which can be defined as a typical "global city region". The index method shows that the position of St. Petersburg in the system of global coastal cities of the Baltic region is relatively favorable in view of its transport, logistics, and demographic potential and the advantageous geo-economic situation. St. Petersburg has certain competitive advantages in the region brought about by its demographic potential, port freight capacity, and the favorable geo-economic position of the "sea gate" of Russia. However, the level of high-tech services and ‘new economy’ development is not sufficient for the port to become a match for the top three cities (Stockholm, Helsinki, and Copenhagen. This is increasingly important because transboundary global city networks demonstrate that global cities are functions of global networks. Saint Petersburg is just starting to integrate into these networks through the Pulkovo airline hub and seaports of Ust-Luga, Primorsk, and Saint Petersburg.

  1. Parallel arrangements of positive feedback loops limit cell-to-cell variability in differentiation.

    Directory of Open Access Journals (Sweden)

    Anupam Dey

    Full Text Available Cellular differentiations are often regulated by bistable switches resulting from specific arrangements of multiple positive feedback loops (PFL fused to one another. Although bistability generates digital responses at the cellular level, stochasticity in chemical reactions causes population heterogeneity in terms of its differentiated states. We hypothesized that the specific arrangements of PFLs may have evolved to minimize the cellular heterogeneity in differentiation. In order to test this we investigated variability in cellular differentiation controlled either by parallel or serial arrangements of multiple PFLs having similar average properties under extrinsic and intrinsic noises. We find that motifs with PFLs fused in parallel to one another around a central regulator are less susceptible to noise as compared to the motifs with PFLs arranged serially. Our calculations suggest that the increased resistance to noise in parallel motifs originate from the less sensitivity of bifurcation points to the extrinsic noise. Whereas estimation of mean residence times indicate that stable branches of bifurcations are robust to intrinsic noise in parallel motifs as compared to serial motifs. Model conclusions are consistent both in AND- and OR-gate input signal configurations and also with two different modeling strategies. Our investigations provide some insight into recent findings that differentiation of preadipocyte to mature adipocyte is controlled by network of parallel PFLs.

  2. Kinematic Precise Point Positioning Using Multi-Constellation Global Navigation Satellite System (GNSS Observations

    Directory of Open Access Journals (Sweden)

    Xidong Yu

    2017-01-01

    Full Text Available Multi-constellation global navigation satellite systems (GNSSs are expected to enhance the capability of precise point positioning (PPP by improving the positioning accuracy and reducing the convergence time because more satellites will be available. This paper discusses the performance of multi-constellation kinematic PPP based on a multi-constellation kinematic PPP model, Kalman filter and stochastic models. The experimental dataset was collected from the receivers on a vehicle and processed using self-developed software. A comparison of the multi-constellation kinematic PPP and real-time kinematic (RTK results revealed that the availability, positioning accuracy and convergence performance of the multi-constellation kinematic PPP were all better than those of both global positioning system (GPS-based PPP and dual-constellation PPP. Multi-constellation kinematic PPP can provide a positioning service with centimetre-level accuracy for dynamic users.

  3. Identification of underground mine workings with the use of global positioning system technology

    Energy Technology Data Exchange (ETDEWEB)

    Canty, G.A.; Everett, J.W. [Univ. of Oklahoma, Norman, OK (United States). Dept. of Civil Engineering and Environmental Science; Sharp, M. [Oklahoma Conservation Commission, Oklahoma City, OK (United States). Abandoned Mine Land Reclamation Program

    1998-12-31

    Identification of underground mine workings for well drilling is a difficult task given the limited resources available and lack of reliable information. Relic mine maps of questionable accuracy and difficulty in correlating the subsurface to the surface, make the process of locating wells arduous. With the development of global positioning system (GPS), specific locations on the earth can be identified with the aid of satellites. This technology can be applied to mine workings identification given a few necessary, precursory details. For an abandoned mine treatment project conducted by the University of Oklahoma, in conjunction with the Oklahoma Conservation Commission, a Trimble ProXL 8 channel GPS receiver was employed to locate specific points on the surface with respect to a mine map. A 1925 mine map was digitized into AutoCAD version 13 software. Surface features identified on the map, such as mine adits, were located and marked in the field using the GPS receiver. These features were than imported into AutoCAD and referenced with the same points drawn on the map. A rubber sheeting program, Multric, was used to tweak the points so the map features correlated with the surface points. The correlation of these features allowed the map to be geo-referenced with the surface. Specific drilling points were located on the digitized map and assigned a latitude and longitude. The GPS receiver, using real time differential correction, was used to locate these points in the field. This method was assumed to be relatively accurate, to within 5 to 15 feet.

  4. Identification of underground mine workings with the use of global positioning system technology

    International Nuclear Information System (INIS)

    Canty, G.A.; Everett, J.W.; Sharp, M.

    1998-01-01

    Identification of underground mine workings for well drilling is a difficult task given the limited resources available and lack of reliable information. Relic mine maps of questionable accuracy and difficulty in correlating the subsurface to the surface, make the process of locating wells arduous. With the development of global positioning system (GPS), specific locations on the earth can be identified with the aid of satellites. This technology can be applied to mine workings identification given a few necessary, precursory details. For an abandoned mine treatment project conducted by the University of Oklahoma, in conjunction with the Oklahoma Conservation Commission, a Trimble ProXL 8 channel GPS receiver was employed to locate specific points on the surface with respect to a mine map. A 1925 mine map was digitized into AutoCAD version 13 software. Surface features identified on the map, such as mine adits, were located and marked in the field using the GPS receiver. These features were than imported into AutoCAD and referenced with the same points drawn on the map. A rubber sheeting program, Multric, was used to tweak the points so the map features correlated with the surface points. The correlation of these features allowed the map to be geo-referenced with the surface. Specific drilling points were located on the digitized map and assigned a latitude and longitude. The GPS receiver, using real time differential correction, was used to locate these points in the field. This method was assumed to be relatively accurate, to within 5 to 15 feet

  5. The linear variable differential transformer (LVDT) position sensor for gravitational wave interferometer low-frequency controls

    Energy Technology Data Exchange (ETDEWEB)

    Tariq, Hareem E-mail: htariq@ligo.caltech.edu; Takamori, Akiteru; Vetrano, Flavio; Wang Chenyang; Bertolini, Alessandro; Calamai, Giovanni; DeSalvo, Riccardo; Gennai, Alberto; Holloway, Lee; Losurdo, Giovanni; Marka, Szabolcs; Mazzoni, Massimo; Paoletti, Federico; Passuello, Diego; Sannibale, Virginio; Stanga, Ruggero

    2002-08-21

    Low-power, ultra-high-vacuum compatible, non-contacting position sensors with nanometer resolution and centimeter dynamic range have been developed, built and tested. They have been designed at Virgo as the sensors for low-frequency modal damping of Seismic Attenuation System chains in Gravitational Wave interferometers and sub-micron absolute mirror positioning. One type of these linear variable differential transformers (LVDTs) has been designed to be also insensitive to transversal displacement thus allowing 3D movement of the sensor head while still precisely reading its position along the sensitivity axis. A second LVDT geometry has been designed to measure the displacement of the vertical seismic attenuation filters from their nominal position. Unlike the commercial LVDTs, mostly based on magnetic cores, the LVDTs described here exert no force on the measured structure.

  6. Geometric methods of global attraction in systems of delay differential equations

    Science.gov (United States)

    El-Morshedy, Hassan A.; Ruiz-Herrera, Alfonso

    2017-11-01

    In this paper we deduce criteria of global attraction in systems of delay differential equations. Our methodology is new and consists in "dominating" the nonlinear terms of the system by a scalar function and then studying some dynamical properties of that function. One of the crucial benefits of our approach is that we obtain delay-dependent results of global attraction that cover the best delay-independent conditions. We apply our results in a gene regulatory model and the classical Nicholson's blowfly equation with patch structure.

  7. Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

    Science.gov (United States)

    Ostrow, Sheli L.; Barshir, Ruth; DeGregori, James; Yeger-Lotem, Esti; Hershberg, Ruth

    2014-01-01

    Cancer is an evolutionary process in which cells acquire new transformative, proliferative and metastatic capabilities. A full understanding of cancer requires learning the dynamics of the cancer evolutionary process. We present here a large-scale analysis of the dynamics of this evolutionary process within tumors, with a focus on breast cancer. We show that the cancer evolutionary process differs greatly from organismal (germline) evolution. Organismal evolution is dominated by purifying selection (that removes mutations that are harmful to fitness). In contrast, in the cancer evolutionary process the dominance of purifying selection is much reduced, allowing for a much easier detection of the signals of positive selection (adaptation). We further show that, as a group, genes that are globally expressed across human tissues show a very strong signal of positive selection within tumors. Indeed, known cancer genes are enriched for global expression patterns. Yet, positive selection is prevalent even on globally expressed genes that have not yet been associated with cancer, suggesting that globally expressed genes are enriched for yet undiscovered cancer related functions. We find that the increased positive selection on globally expressed genes within tumors is not due to their expression in the tissue relevant to the cancer. Rather, such increased adaptation is likely due to globally expressed genes being enriched in important housekeeping and essential functions. Thus, our results suggest that tumor adaptation is most often mediated through somatic changes to those genes that are important for the most basic cellular functions. Together, our analysis reveals the uniqueness of the cancer evolutionary process and the particular importance of globally expressed genes in driving cancer initiation and progression. PMID:24603726

  8. Remote Sensing Global Surface Air Pressure Using Differential Absorption BArometric Radar (DiBAR)

    Science.gov (United States)

    Lin, Bing; Harrah, Steven; Lawrence, Wes; Hu, Yongxiang; Min, Qilong

    2016-01-01

    Tropical storms and severe weathers are listed as one of core events that need improved observations and predictions in World Meteorological Organization and NASA Decadal Survey (DS) documents and have major impacts on public safety and national security. This effort tries to observe surface air pressure, especially over open seas, from space using a Differential-absorption BArometric Radar (DiBAR) operating at the 50-55 gigahertz O2 absorption band. Air pressure is among the most important variables that affect atmospheric dynamics, and currently can only be measured by limited in-situ observations over oceans. Analyses show that with the proposed space radar the errors in instantaneous (averaged) pressure estimates can be as low as approximately 4 millibars (approximately 1 millibar under all weather conditions). With these sea level pressure measurements, the forecasts of severe weathers such as hurricanes will be significantly improved. Since the development of the DiBAR concept about a decade ago, NASA Langley DiBAR research team has made substantial progress in advancing the concept. The feasibility assessment clearly shows the potential of sea surface barometry using existing radar technologies. The team has developed a DiBAR system design, fabricated a Prototype-DiBAR (P-DiBAR) for proof-of-concept, conducted lab, ground and airborne P-DiBAR tests. The flight test results are consistent with the instrumentation goals. Observational system simulation experiments for space DiBAR performance based on the existing DiBAR technology and capability show substantial improvements in tropical storm predictions, not only for the hurricane track and position but also for the hurricane intensity. DiBAR measurements will lead us to an unprecedented level of the prediction and knowledge on global extreme weather and climate conditions.

  9. A theoretical ovary position in link with the global anatomical structure of each human female body

    OpenAIRE

    Hassen Chaabani

    2013-01-01

    Generally the position of different organs is determined by simple description following the anatomical elements surrounded them and such description could be developed and applied in surgical anatomy. Here, I present for the first time a theoretical three-dimensional ovary position in link with the global anatomical structure of each human female body. I advance the fact that ovaries are placed between two anatomical planes: a first plane of a frontal section touching at the top the internal...

  10. Differential expression profile prioritization of positional candidate glaucoma genes: the GLC1C locus.

    Science.gov (United States)

    Rozsa, Frank W; Scott, Kathleen M; Pawar, Hemant; Samples, John R; Wirtz, Mary K; Richards, Julia E

    2007-01-01

    To develop and apply a model for prioritization of candidate glaucoma genes. This Affymetrix GeneChip (Affymetrix, Santa Clara, Calif) study of gene expression in primary culture human trabecular meshwork cells uses a positional differential expression profile model for prioritization of candidate genes within the GLC1C genetic inclusion interval. Sixteen genes were expressed under all conditions within the GLC1C interval. TMEM22 was the only gene within the interval with differential expression in the same direction under both conditions tested. Two genes, ATP1B3 and COPB2, are of interest in the context of a protein-misfolding model for candidate selection. SLC25A36, PCCB, and FNDC6 are of lesser interest because of moderate expression and changes in expression. Transcription factor ZBTB38 emerges as an interesting candidate gene because of the overall expression level, differential expression, and function. Only 1 gene in the GLC1C interval fits our model for differential expression under multiple glaucoma risk conditions. The use of multiple prioritization models resulted in filtering 7 candidate genes of higher interest out of the 41 known genes in the region. This study identified a small subset of genes that are most likely to harbor mutations that cause glaucoma linked to GLC1C.

  11. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

    Science.gov (United States)

    Kang, Jong-Sun; Mulieri, Philip J.; Hu, Yulan; Taliana, Lavinia; Krauss, Robert S.

    2002-01-01

    CDO is a cell surface receptor-like protein that positively regulates myogenic differentiation. Reported here is the identification of BOC, which, with CDO, defines a newly recognized subfamily within the immunoglobulin superfamily. cdo and boc are co-expressed in muscle precursors in the developing mouse embryo. Like CDO, BOC accelerates differentiation of cultured myoblast cell lines and participates in a positive feedback loop with the myogenic transcription factor, MyoD. CDO and BOC form complexes in a cis fashion via association of both their ectodomains and their intracellular domains. A soluble fusion protein that contains the entire BOC ectodomain functions similarly to full-length BOC to promote myogenic differentiation, indicating that the intracellular region is dispensable for its activity in this system. Furthermore, a dominant-negative form of CDO inhibits the pro-myogenic effects of soluble BOC, suggesting that BOC is dependent on CDO for its activity. CDO and BOC are proposed to be components of a receptor complex that mediates some of the cell–cell interactions between muscle precursors that are required for myogenesis. PMID:11782431

  12. Evaluation of Vienna’s World Economic Position Based on Global and World City Rankings

    Directory of Open Access Journals (Sweden)

    Andrea Uszkai

    2016-12-01

    Full Text Available Metropolitan areas play a dominant role in today’s economic, social and environmental processes; therefore the scientific interest has also increased related to the global and world cities. They can be considered as key players of the world economy and a very complex competition takes place among them, which crosses the national state borders. Every city tries to reach the most favorable position and this rivalry has helped the birth of several city rankings. This paper has two important aims. Firstly, it explains the term of the world and global city based on the international literature and it is also looking for the answer, whether the Austrian capital belongs to which category. Secondly, it examines the position of Vienna in the different world and global city rankings.

  13. Positive global solutions for a general model of size-dependent population dynamics

    OpenAIRE

    Kato, Nobuyuki

    2000-01-01

    We study size-structured population models of general type which have the growth rate depending on the size and time. The local existence and uniqueness of the solution have been shown by Kato and Torikata (1997). Here, we discuss the positivity of the solution and global existence as well as $L^\\infty$ solutions.

  14. Positive global solutions for a general model of size-dependent population dynamics

    Directory of Open Access Journals (Sweden)

    Nobuyuki Kato

    2000-01-01

    have the growth rate depending on the size and time. The local existence and uniqueness of the solution have been shown by Kato and Torikata (1997. Here, we discuss the positivity of the solution and global existence as well as L ∞ solutions.

  15. 77 FR 37430 - BSEE Information Collection Activity: Global Positioning System for MODUs, Extension of a...

    Science.gov (United States)

    2012-06-21

    ... major weather event, like a hurricane, lessees and operators need to report new GPS information to BSEE...-0012; OMB Control Number 1014-0013] BSEE Information Collection Activity: Global Positioning System for... Paperwork Reduction Act of 1995 (PRA), BSEE is inviting comments on a collection of information pertaining...

  16. Causes and consequences of timing errors associated with global positioning system collar accelerometer activity monitors

    Science.gov (United States)

    Adam J. Gaylord; Dana M. Sanchez

    2014-01-01

    Direct behavioral observations of multiple free-ranging animals over long periods of time and large geographic areas is prohibitively difficult. However, recent improvements in technology, such as Global Positioning System (GPS) collars equipped with motion-sensitive activity monitors, create the potential to remotely monitor animal behavior. Accelerometer-equipped...

  17. Combining A Priori Knowledge and Sensor Information for Updating the Global Position of an Autonomous Vehicle

    NARCIS (Netherlands)

    Zivkovic, Z.; Schoute, Albert L.; van der Heijden, Ferdinand; van Amerongen, J.; Jonker, B.; Regtien, P.P.L; Stramigioli, S.

    The problem of updating the global position of an autonomous vehicle is considered. An iterative procedure is proposed to fit a map to a set of noisy measurements. The procedure is inspired by a non-parametric procedure for probability density function mode searching. We show how this could be used

  18. Global positioning system for general aviation: Joint FAA-NASA Seminar. [conferences

    Science.gov (United States)

    1978-01-01

    Programs to examine and develop means to utilize the global positioning system (GPS) for civil aviation functions are described. User requirements in this regard are discussed, the development of technologies in the areas of antennas, receivers, and signal processors for the GPS are examined, and modifications to the GPS to fit operational and design criteria are evaluated.

  19. Global stabilisation of large-scale hydraulic networks with quantised and positive proportional controls

    DEFF Research Database (Denmark)

    Jensen, Tom Nørgaard; Wisniewski, Rafal

    2013-01-01

    is extended by showing that an attractor set with a global basin of attraction exists for arbitrary values of positive control gains, given that the upper level of the quantiser is properly designed. Furthermore, the proof is given for general monotone quantisation maps. Since the basin of attraction...

  20. 76 FR 31943 - Global Positioning System Directorate (Gpsd); Notice of Meeting

    Science.gov (United States)

    2011-06-02

    ...); Notice of Meeting ACTION: Notice of Meeting--Public Interface Control Working Group (ICWG) for Signals-in... that the Global Positioning Systems (GPS) Directorate will be hosting a Public Interface Control... the Was/Is Matrix, current versions of the documents, and the official meeting notice will be posted...

  1. Existence of positive solutions for boundary value problem of second-order functional differential equation

    Directory of Open Access Journals (Sweden)

    Daqing Jiang

    1998-01-01

    Full Text Available We use a fixed point index theorem in cones to study the existence of positive solutions for boundary value problems of second-order functional differential equations of the form $$\\left\\{ \\begin{array}{ll} y''(x+r(xf(y(w(x=0,&0differential equations.

  2. Existence of Positive Solutions to a Boundary Value Problem for a Delayed Nonlinear Fractional Differential System

    Directory of Open Access Journals (Sweden)

    Chen Yuming

    2011-01-01

    Full Text Available Though boundary value problems for fractional differential equations have been extensively studied, most of the studies focus on scalar equations and the fractional order between 1 and 2. On the other hand, delay is natural in practical systems. However, not much has been done for fractional differential equations with delays. Therefore, in this paper, we consider a boundary value problem of a general delayed nonlinear fractional system. With the help of some fixed point theorems and the properties of the Green function, we establish several sets of sufficient conditions on the existence of positive solutions. The obtained results extend and include some existing ones and are illustrated with some examples for their feasibility.

  3. Differential barometric-based positioning technique for indoor elevation measurement in IoT medical applications.

    Science.gov (United States)

    Wang, Hua; Wen, Yingyou; Zhao, Dazhe

    2017-07-20

    Medical applications have begun to benefit from Internet of Things (IoT) technology through the introduction of wearable devices. Several medical applications require accurate patient location as various changes affect pressure parameters inside the body. This study aims to develop a system to measure indoor altitude for IoT medical applications. We propose a differential barometric-based positioning system to estimate the altitude between a reference sensor and a localizing sensor connected to the human body. The differential barometric altimetry model is introduced to estimate indoor elevations and eliminate environmental artifacts. In addition, a Gaussian filter processing is adopted to remove noise from the elevation measurements. The proposed system is then investigated through extensive experiments, using various evaluation criteria. The results indicate that the proposed system yielded good accuracy with reduced implementation complexity and fewer costs. The proposed system is resilient compared to other indoor localization approaches, even when numerous environmental artifacts in indoor environments are present.

  4. Fusion of Location Fingerprinting and Trilateration Based on the Example of Differential Wi-Fi Positioning

    Science.gov (United States)

    Retscher, G.

    2017-09-01

    Positioning of mobile users in indoor environments with Wireless Fidelity (Wi-Fi) has become very popular whereby location fingerprinting and trilateration are the most commonly employed methods. In both the received signal strength (RSS) of the surrounding access points (APs) are scanned and used to estimate the user's position. Within the scope of this study the advantageous qualities of both methods are identified and selected to benefit their combination. By a fusion of these technologies a higher performance for Wi-Fi positioning is achievable. For that purpose, a novel approach based on the well-known Differential GPS (DGPS) principle of operation is developed and applied. This approach for user localization and tracking is termed Differential Wi-Fi (DWi-Fi) by analogy with DGPS. From reference stations deployed in the area of interest differential measurement corrections are derived and applied at the mobile user side. Hence, range or coordinate corrections can be estimated from a network of reference station observations as it is done in common CORS GNSS networks. A low-cost realization with Raspberry Pi units is employed for these reference stations. These units serve at the same time as APs broadcasting Wi-Fi signals as well as reference stations scanning the receivable Wi-Fi signals of the surrounding APs. As the RSS measurements are carried out continuously at the reference stations dynamically changing maps of RSS distributions, so-called radio maps, are derived. Similar as in location fingerprinting this radio maps represent the RSS fingerprints at certain locations. From the areal modelling of the correction parameters in combination with the dynamically updated radio maps the location of the user can be estimated in real-time. The novel approach is presented and its performance demonstrated in this paper.

  5. Position Estimation and Local Mapping Using Omnidirectional Images and Global Appearance Descriptors

    Directory of Open Access Journals (Sweden)

    Yerai Berenguer

    2015-10-01

    Full Text Available This work presents some methods to create local maps and to estimate the position of a mobile robot, using the global appearance of omnidirectional images. We use a robot that carries an omnidirectional vision system on it. Every omnidirectional image acquired by the robot is described only with one global appearance descriptor, based on the Radon transform. In the work presented in this paper, two different possibilities have been considered. In the first one, we assume the existence of a map previously built composed of omnidirectional images that have been captured from previously-known positions. The purpose in this case consists of estimating the nearest position of the map to the current position of the robot, making use of the visual information acquired by the robot from its current (unknown position. In the second one, we assume that we have a model of the environment composed of omnidirectional images, but with no information about the location of where the images were acquired. The purpose in this case consists of building a local map and estimating the position of the robot within this map. Both methods are tested with different databases (including virtual and real images taking into consideration the changes of the position of different objects in the environment, different lighting conditions and occlusions. The results show the effectiveness and the robustness of both methods.

  6. Modelling Movement Energetics Using Global Positioning System Devices in Contact Team Sports: Limitations and Solutions.

    Science.gov (United States)

    Gray, Adrian J; Shorter, Kathleen; Cummins, Cloe; Murphy, Aron; Waldron, Mark

    2018-03-27

    Quantifying the training and competition loads of players in contact team sports can be performed in a variety of ways, including kinematic, perceptual, heart rate or biochemical monitoring methods. Whilst these approaches provide data relevant for team sports practitioners and athletes, their application to a contact team sport setting can sometimes be challenging or illogical. Furthermore, these methods can generate large fragmented datasets, do not provide a single global measure of training load and cannot adequately quantify all key elements of performance in contact team sports. A previous attempt to address these limitations via the estimation of metabolic energy demand (global energy measurement) has been criticised for its inability to fully quantify the energetic costs of team sports, particularly during collisions. This is despite the seemingly unintentional misapplication of the model's principles to settings outside of its intended use. There are other hindrances to the application of such models, which are discussed herein, such as the data-handling procedures of Global Position System manufacturers and the unrealistic expectations of end users. Nevertheless, we propose an alternative energetic approach, based on Global Positioning System-derived data, to improve the assessment of mechanical load in contact team sports. We present a framework for the estimation of mechanical work performed during locomotor and contact events with the capacity to globally quantify the work done during training and matches.

  7. Global regulator SATB1 recruits beta-catenin and regulates T(H2 differentiation in Wnt-dependent manner.

    Directory of Open Access Journals (Sweden)

    Dimple Notani

    2010-01-01

    Full Text Available In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of beta-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs to activate target genes. Wnt/beta -catenin signalling is essential for T cell development and differentiation. Here we show that special AT-rich binding protein 1 (SATB1, the T lineage-enriched chromatin organizer and global regulator, interacts with beta-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signalling. Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon beta-catenin signalling. GATA-3 is a T helper type 2 (T(H2 specific transcription factor that regulates production of T(H2 cytokines and functions as T(H2 lineage determinant. SATB1 positively regulated GATA-3 and siRNA-mediated knockdown of SATB1 downregulated GATA-3 expression in differentiating human CD4(+ T cells, suggesting that SATB1 influences T(H2 lineage commitment by reprogramming gene expression. In the presence of Dickkopf 1 (Dkk1, an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature T(H2 cytokines such as IL-4, IL-10, and IL-13 is reduced, indicating that Wnt signalling is essential for T(H2 differentiation. Knockdown of beta-catenin also produced similar results, confirming the role of Wnt/beta-catenin signalling in T(H2 differentiation. Furthermore, chromatin immunoprecipitation analysis revealed that SATB1 recruits beta-catenin and p300 acetyltransferase on GATA-3 promoter in differentiating T(H2 cells in a Wnt-dependent manner. SATB1 coordinates T(H2 lineage commitment by reprogramming gene expression. The SATB1:beta-catenin complex activates a number of SATB1 regulated genes, and hence this study has potential to find novel Wnt responsive genes. These results demonstrate that SATB1

  8. SGO: A fast engine for ab initio atomic structure global optimization by differential evolution

    Science.gov (United States)

    Chen, Zhanghui; Jia, Weile; Jiang, Xiangwei; Li, Shu-Shen; Wang, Lin-Wang

    2017-10-01

    As the high throughout calculations and material genome approaches become more and more popular in material science, the search for optimal ways to predict atomic global minimum structure is a high research priority. This paper presents a fast method for global search of atomic structures at ab initio level. The structures global optimization (SGO) engine consists of a high-efficiency differential evolution algorithm, accelerated local relaxation methods and a plane-wave density functional theory code running on GPU machines. The purpose is to show what can be achieved by combining the superior algorithms at the different levels of the searching scheme. SGO can search the global-minimum configurations of crystals, two-dimensional materials and quantum clusters without prior symmetry restriction in a relatively short time (half or several hours for systems with less than 25 atoms), thus making such a task a routine calculation. Comparisons with other existing methods such as minima hopping and genetic algorithm are provided. One motivation of our study is to investigate the properties of magnetic systems in different phases. The SGO engine is capable of surveying the local minima surrounding the global minimum, which provides the information for the overall energy landscape of a given system. Using this capability we have found several new configurations for testing systems, explored their energy landscape, and demonstrated that the magnetic moment of metal clusters fluctuates strongly in different local minima.

  9. Iodine-131 in Helicobacter pylori-positive patients: preliminary accidental finding and in differentiated thyroid cancer.

    Science.gov (United States)

    Xu, Fei; Tang, Linling; Yuan, Hong; Liu, Jianjun; Huang, Gang; Song, Shaoli

    2016-11-01

    To investigate the eradicate effect of Helicobacter pylori in differentiated thyroid cancer patients who underwent I therapy. A total of 130 patients with differentiated thyroid cancer underwent I treatment. None of the patients had a history of stomach-related diseases. The C-urea breath test (UBT) was carried out for H. pylori examination before I treatment. The cut-off value for C-UBT was 4%. For H. pylori test-positive patients, a second C-UBT was performed 4-6 weeks after I treatment. T-tests were used to compare the difference before and 4-6 weeks after I treatment. A total of 42 of 130 (32.31%) patients were H. pylori positive. The average value of H. pylori was 28.36% before I, whereas the value was 18.18% after I therapy. A significant decrease in C-UBT was found after I treatment compared with before therapy (Ppylori, which could provide a new approach to multidrug resistance pathogens. As the exact molecular mechanism of this phenomenon is still unclear, future clinical applications of this anecdotal finding require further assessments.

  10. Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells.

    Science.gov (United States)

    Doyle, Kharen L; Cunha, Carla; Hort, Yvonne; Tasan, Ramon; Sperk, Günther; Shine, John; Herzog, Herbert

    2018-04-01

    The mouse olfactory neuroepithelium (ON) is comprised of anatomically distinct populations of cells in separate regions; apical (sustentacular and microvillar), neuronal (olfactory sensory neurons) and basal (horizontal and globose basal cells). The existence of microvillar cells (MVCs) is well documented but their nature and function remains unclear. An important transcription factor for the differentiation of MVCs is Skn-1a, with loss of function of Skn-1a in mice resulting in a complete loss of Trpm-5 expressing MVCs, while olfactory sensory neuron differentiation is normal. Our previous research has shown that neuropeptide Y (NPY) is expressed in MVCs and is important in the neuroproliferation of olfactory precursors. This study showed that following X-ray irradiation of the snout of wildtype mice, which decreases the proliferation of basal precursor cells, the numbers of Trpm-5-positive MVCs is increased at 2 and 5 weeks post-irradiation compared to controls. Skn-1a expression in the ON following X-ray irradiation also increases at 2 weeks post-irradiation in a regionally specific manner matching the expression pattern of Trpm-5-positive MVCs. In parallel, NPYCre knock-in mice were used to examine the expression of Skn-1a following activation of NPY unilaterally in the ON (unilateral nasal irrigation of AAV-NPY-FLEX). These experiments demonstrated that Skn-1a is only expressed when NPY is activated in MVCs. Therefore the expression of NPY is necessary for the transcription factor-mediated differentiation of olfactory MVCs. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Comparison of bottom-track to global positioning system referenced discharges measured using an acoustic Doppler current profiler

    Science.gov (United States)

    Wagner, Chad R.; Mueller, David S.

    2011-01-01

    A negative bias in discharge measurements made with an acoustic Doppler current profiler (ADCP) can be caused by the movement of sediment on or near the streambed. The integration of a global positioning system (GPS) to track the movement of the ADCP can be used to avoid the systematic negative bias associated with a moving streambed. More than 500 discharge transects from 63 discharge measurements with GPS data were collected at sites throughout the US, Canada, and New Zealand with no moving bed to compare GPS and bottom-track-referenced discharges. Although the data indicated some statistical bias depending on site conditions and type of GPS data used, these biases were typically about 0.5% or less. An assessment of differential correction sources was limited by a lack of data collected in a range of different correction sources and different GPS receivers at the same sites. Despite this limitation, the data indicate that the use of Wide Area Augmentation System (WAAS) corrected positional data is acceptable for discharge measurements using GGA as the boat-velocity reference. The discharge data based on GPS-referenced boat velocities from the VTG data string, which does not require differential correction, were comparable to the discharges based on GPS-referenced boat velocities from the differentially-corrected GGA data string. Spatial variability of measure discharges referenced to GGA, VTG and bottom-tracking is higher near the channel banks. The spatial variability of VTG-referenced discharges is correlated with the spatial distribution of maximum Horizontal Dilution of Precision (HDOP) values and the spatial variability of GGA-referenced discharges is correlated with proximity to channel banks.

  12. Global transcriptome analysis of spore formation in Myxococcus xanthus reveals a locus necessary for cell differentiation

    Directory of Open Access Journals (Sweden)

    Treuner-Lange Anke

    2010-04-01

    Full Text Available Abstract Background Myxococcus xanthus is a Gram negative bacterium that can differentiate into metabolically quiescent, environmentally resistant spores. Little is known about the mechanisms involved in differentiation in part because sporulation is normally initiated at the culmination of a complex starvation-induced developmental program and only inside multicellular fruiting bodies. To obtain a broad overview of the sporulation process and to identify novel genes necessary for differentiation, we instead performed global transcriptome analysis of an artificial chemically-induced sporulation process in which addition of glycerol to vegetatively growing liquid cultures of M. xanthus leads to rapid and synchronized differentiation of nearly all cells into myxospore-like entities. Results Our analyses identified 1 486 genes whose expression was significantly regulated at least two-fold within four hours of chemical-induced differentiation. Most of the previously identified sporulation marker genes were significantly upregulated. In contrast, most genes that are required to build starvation-induced multicellular fruiting bodies, but which are not required for sporulation per se, were not significantly regulated in our analysis. Analysis of functional gene categories significantly over-represented in the regulated genes, suggested large rearrangements in core metabolic pathways, and in genes involved in protein synthesis and fate. We used the microarray data to identify a novel operon of eight genes that, when mutated, rendered cells unable to produce viable chemical- or starvation-induced spores. Importantly, these mutants displayed no defects in building fruiting bodies, suggesting these genes are necessary for the core sporulation process. Furthermore, during the starvation-induced developmental program, these genes were expressed in fruiting bodies but not in peripheral rods, a subpopulation of developing cells which do not sporulate

  13. Search for domain wall dark matter with atomic clocks on board global positioning system satellites.

    Science.gov (United States)

    Roberts, Benjamin M; Blewitt, Geoffrey; Dailey, Conner; Murphy, Mac; Pospelov, Maxim; Rollings, Alex; Sherman, Jeff; Williams, Wyatt; Derevianko, Andrei

    2017-10-30

    Cosmological observations indicate that dark matter makes up 85% of all matter in the universe yet its microscopic composition remains a mystery. Dark matter could arise from ultralight quantum fields that form macroscopic objects. Here we use the global positioning system as a ~ 50,000 km aperture dark matter detector to search for such objects in the form of domain walls. Global positioning system navigation relies on precision timing signals furnished by atomic clocks. As the Earth moves through the galactic dark matter halo, interactions with domain walls could cause a sequence of atomic clock perturbations that propagate through the satellite constellation at galactic velocities ~ 300 km s -1 . Mining 16 years of archival data, we find no evidence for domain walls at our current sensitivity level. This improves the limits on certain quadratic scalar couplings of domain wall dark matter to standard model particles by several orders of magnitude.

  14. Physical Demands of Top-Class Soccer Friendly Matches in Relation to a Playing Position Using Global Positioning System Technology.

    Science.gov (United States)

    Mallo, Javier; Mena, Esteban; Nevado, Fabio; Paredes, Víctor

    2015-09-29

    The aim of this study was to examine the physical demands imposed on professional soccer players during 11-a-side friendly matches in relation to their playing position, using global positioning system (GPS) technology. One hundred and eleven match performances of a Spanish "La Liga" team during the 2010-11 and 2011-12 pre-seasons were selected for analysis. The activities of the players were monitored using GPS technology with a sampling frequency of 1 Hz. Total distance covered, distance in different speed categories, accelerations, and heart rate responses were analyzed in relation to five different playing positions: central defenders (n=23), full-backs (n=20), central midfielders (n=22), wide midfielders (n=26), and forwards (n=20). Distance covered during a match averaged 10.8 km, with wide and central midfielders covering the greatest total distance. Specifically, wide midfielders covered the greatest distances by very high-intensity running (>19.8 km·h-1) and central midfielders by jogging and running (7.2-19.7 km·h-1). On the other hand, central defenders covered the least total distance and at high intensity, although carried out more (pwork rate profile of the players obtained with the GPS was very similar to that obtained with semi-automatic image technologies. However, when comparing results from this study with data available in the literature, important differences were detected in the amount of distance covered by sprinting, which suggests that caution should be taken when comparing data obtained with the GPS with other motion analysis systems, especially regarding high-intensity activities.

  15. Physical Demands of Top-Class Soccer Friendly Matches in Relation to a Playing Position Using Global Positioning System Technology

    Directory of Open Access Journals (Sweden)

    Mallo Javier

    2015-09-01

    Full Text Available The aim of this study was to examine the physical demands imposed on professional soccer players during 11-a-side friendly matches in relation to their playing position, using global positioning system (GPS technology. One hundred and eleven match performances of a Spanish “La Liga” team during the 2010-11 and 2011-12 pre-seasons were selected for analysis. The activities of the players were monitored using GPS technology with a sampling frequency of 1 Hz. Total distance covered, distance in different speed categories, accelerations, and heart rate responses were analyzed in relation to five different playing positions: central defenders (n=23, full-backs (n=20, central midfielders (n=22, wide midfielders (n=26, and forwards (n=20. Distance covered during a match averaged 10.8 km, with wide and central midfielders covering the greatest total distance. Specifically, wide midfielders covered the greatest distances by very high-intensity running (>19.8 km·h-1 and central midfielders by jogging and running (7.2-19.7 km·h-1. On the other hand, central defenders covered the least total distance and at high intensity, although carried out more (p<0.05-0.01 accelerations than forwards, wide midfielders, and fullbacks. The work rate profile of the players obtained with the GPS was very similar to that obtained with semi-automatic image technologies. However, when comparing results from this study with data available in the literature, important differences were detected in the amount of distance covered by sprinting, which suggests that caution should be taken when comparing data obtained with the GPS with other motion analysis systems, especially regarding high-intensity activities.

  16. A Short Tutorial on Inertial Navigation System and Global Positioning System Integration

    Science.gov (United States)

    Smalling, Kyle M.; Eure, Kenneth W.

    2015-01-01

    The purpose of this document is to describe a simple method of integrating Inertial Navigation System (INS) information with Global Positioning System (GPS) information for an improved estimate of vehicle attitude and position. A simple two dimensional (2D) case is considered. The attitude estimates are derived from sensor data and used in the estimation of vehicle position and velocity through dead reckoning within the INS. The INS estimates are updated with GPS estimates using a Kalman filter. This tutorial is intended for the novice user with a focus on bringing the reader from raw sensor measurements to an integrated position and attitude estimate. An application is given using a remotely controlled ground vehicle operating in assumed 2D environment. The theory is developed first followed by an illustrative example.

  17. Upgrading to lead firm position via international acquisition: learning from the global biomass power plant industry

    DEFF Research Database (Denmark)

    Hansen, Ulrich Elmer; Fold, Niels; Hansen, Teis

    2016-01-01

    This article examines the case of a Chinese firm that has upgraded to lead firm position in the global biomass power plant industry mainly through acquisitions of technological frontier firms in Denmark. Sustaining the lead firm position was, however, challenged by difficulties in developing...... innovative capability. Drawing on the literature on (i) firm-level technological capability and (ii) knowledge transfer in international acquisitions, we explain the reasons for insufficient innovative capability building. Based on these empirical findings, we suggest maintaining the existing upgrading...

  18. The Global Positioning System for Military Users: Current Modernization Plans and Alternatives

    Science.gov (United States)

    2011-10-01

    of unexpected satellite failure or loss.Plans for the Ground Control System More-capable GPS satellites alone cannot provide the resistance to jamming...fivefold (or 7 decibel) improvement in the ability to resist jamming.CBO 14 THE GLOBAL POSITIONING SYSTEM FOR MILITARY USERS: CURRENT MODERNIZATION PLANS...the Foucault pendulum but uses a vibrating element, known as a Micro Electro-Mechanical System, instead of an actual pendulum. iGPS Module. The

  19. Global positioning system analysis of running performance in female field sports: A review of the literature

    OpenAIRE

    Hodun, Megan; Clarke, Richard; De Ste Croix, Mark B; Hughes, Jonathan

    2016-01-01

    The use of global positioning systems (GPS) in analyzing field sport performance is a recent development, particularly in soccer, rugby and field hockey. Research with GPS in female field sports has centred on match performance, fatigue, and training intensity. Of particular concern for GPS analysis is the need for standardized methods to determine the occurrence of high-intensity running and sprinting. GPS analysis for female field sport athletes can assist in development of training plans a...

  20. Comparison of Number of Waves Surfed and Duration Using Global Positioning System and Inertial Sensors

    OpenAIRE

    J. Madureira; R. Lagido; I. Sousa

    2015-01-01

    Surf is an increasingly popular sport and its performance evaluation is often qualitative. This work aims at using a smartphone to collect and analyze the GPS and inertial sensors data in order to obtain quantitative metrics of the surfing performance. Two approaches are compared for detection of wave rides, computing the number of waves rode in a surfing session, the starting time of each wave and its duration. The first approach is based on computing the velocity from the Global Positioning...

  1. A review on bridge dynamic displacement monitoring using global positioning system and accelerometer

    Science.gov (United States)

    Yunus, Mohd Zulkifli Mohd; Ibrahim, Nuremira; Ahmad, Fatimah Shafinaz

    2018-02-01

    This paper reviews previous research on bridge dynamic displacement monitoring using Global Positioning System (GPS) and an accelerometer for Structural Health Monitoring (SHM) of bridge. These include the review of the advantages and disadvantages of the measurement as well as the methodology of the measurements used in the recent research study. This review could provide a preliminary decision overview for students or researchers before initiating a research related to the bridge dynamic displacement monitoring.

  2. Governance Mechanism for Global Greenhouse Gas Emissions: A Stochastic Differential Game Approach

    Directory of Open Access Journals (Sweden)

    Wei Yu

    2013-01-01

    Full Text Available Today developed and developing countries have to admit the fact that global warming is affecting the earth, but the fundamental problem of how to divide up necessary greenhouse gas reductions between developed and developing countries remains. In this paper, we propose cooperative and noncooperative stochastic differential game models to describe greenhouse gas emissions decision makings of developed and developing countries, calculate their feedback Nash equilibrium and the Pareto optimal solution, characterize parameter spaces that developed and developing countries can cooperate, design cooperative conditions under which participants buy the cooperative payoff, and distribute the cooperative payoff with Nash bargaining solution. Lastly, numerical simulations are employed to illustrate the above results.

  3. Global stability, periodic solutions, and optimal control in a nonlinear differential delay model

    Directory of Open Access Journals (Sweden)

    Anatoli F. Ivanov

    2010-09-01

    Full Text Available A nonlinear differential equation with delay serving as a mathematical model of several applied problems is considered. Sufficient conditions for the global asymptotic stability and for the existence of periodic solutions are given. Two particular applications are treated in detail. The first one is a blood cell production model by Mackey, for which new periodicity criteria are derived. The second application is a modified economic model with delay due to Ramsey. An optimization problem for a maximal consumption is stated and solved for the latter.

  4. Necessary and sufficient conditions for global-in-time existence of solutions of ordinary, stochastic, and parabolic differential equations

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available We derive necessary and sufficient conditions for global-in-time existence of solutions of ordinary differential, stochastic differential, and parabolic equations. The conditions are formulated in terms of complete Riemannian metrics on extended phase spaces (conditions with two-sided estimates or in terms of derivatives of proper functions on extended phase spaces (conditions with one-sided estimates.

  5. Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.

    Science.gov (United States)

    Paine, Ananta; Woeller, Collynn F; Zhang, Hengwei; de la Luz Garcia-Hernandez, Maria; Huertas, Nelson; Xing, Lianping; Phipps, Richard P; Ritchlin, Christopher T

    2018-01-17

    Thy1 (CD90), a glycosylated, glycophosphatidylinositol-anchored membrane protein highly expressed by subsets of mesenchymal stem cells and fibroblasts, inhibits adipogenesis. The role of Thy1 on bone structure and function has been poorly studied and represents a major knowledge gap. Therefore, we analyzed the long bones of wild-type (WT) and Thy1 knockout (KO) mice with micro-computed tomography (CT) and histomorphometry to compare changes in bone architecture and overall bone structure. micro-CT analysis of long bones revealed Thy1 KO and WT mice fed a high-fat diet demonstrated bone structural parameters at 4 mo that differed significantly between WT and KO mice. A significant reduction in trabecular bone volume was noted in Thy1 KO mice. The most prominent differences were observed in trabecular bone volume ratio and trabecular bone connectivity density. Consistent with micro-CT measurements, histomorphometric analysis also showed decreased bone volume in the obese Thy1 KO mice compared to obese WT mice. In vitro assays revealed that osteogenic conditions increased Thy1 expression during OB differentiation and absence of Thy1 attenuated osteoblastogenesis. Together, these findings support the concept that Thy1 serves as a major mechanistic link to regulate bone formation and negatively regulate adipogenesis.-Paine, A., Woeller, C. F., Zhang, H., Garcia-Hernandez, M. L., Huertas, N., Xing, L., Phipps, R. P., Ritchlin, C. T. Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.

  6. The Positive Properties of Green’s Function for Fractional Differential Equations and Its Applications

    Directory of Open Access Journals (Sweden)

    Fuquan Jiang

    2013-01-01

    Full Text Available We consider the properties of Green’s function for the nonlinear fractional differential equation boundary value problem: D0+αu(t+f(t,u(t+e(t=0,0positive solutions for singular boundary value problems by means of Schauder fixed-point theorem.

  7. Positive solutions for fractional differential equation with a p-Laplacian operator

    Directory of Open Access Journals (Sweden)

    Yunhong LI

    2015-12-01

    Full Text Available This paper studies the following Caputo fractional differential equation with p-Laplacian of higher-order multi-point: Dβ0+(p(Dα0+u(t+f(t,u(t=0,0≤t≤1,l-1<β≤l,n-1<α≤n,(p(Dα0+u(0(i=0,i=0,1,2,…,l-1,u(i(0=0,i=1,2,…,n-1,u(1=∑ m-2 i=1 aiu(ξi。 Using the Schauder fixed point theorem, the existence of positive solution is obtained for the above boundary value problems. An example is presented to illustrate our main theorem.

  8. What's the confusion about fusion?--differentiating positive and negative closeness in lesbian relationships.

    Science.gov (United States)

    Ackbar, Salma; Senn, Charlene Y

    2010-10-01

    This study differentiated between closeness and fusion in lesbian relationships, and examined whether age, adult attachment style, social support, outness, and relationship satisfaction were associated with these variables. Participants consisted of 77 women in long-term, lesbian relationships. Overall, women who reported showing greater closeness toward their partners were more satisfied in their relationships. Age and attachment style were better predictors of closeness and fusion than were social support and outness. The theoretical implications of these findings are discussed. Findings highlight the need for therapists to distinguish between positive and negative types of closeness in lesbian relationships, and avoid pathologizing high levels of closeness in lesbian relationships simply because they may deviate from a heterosexual norm. © 2010 American Association for Marriage and Family Therapy.

  9. Design and Analysis of a Differential Waveguide Structure to Improve Magnetostrictive Linear Position Sensors

    Directory of Open Access Journals (Sweden)

    Hui Zhao

    2011-05-01

    Full Text Available Magnetostrictive linear position sensors (MLPS are high-precision sensors used in the industrial field for measuring the propagation time of ultrasonic signals in a waveguide. To date, MLPS have attracted widespread attention for their accuracy, reliability, and cost-efficiency in performing non-contact, multiple measurements. However, the sensor, with its traditional structure, is susceptible to electromagnetic interference, which affects accuracy. In the present study, we propose a novel structure of MLPS that relies on two differential waveguides to improve the signal-to-noise ratio, common-mode rejection ratio, and accuracy of MLPS. The proposed sensor model can depict sensor performance and the relationship of sensor parameters. Experimental results with the new sensor indicate that the new structure can improve accuracy to ±0.1 mm higher than ±0.2 mm with a traditional structure. In addition, the proposed sensor shows a considerable improvement in temperature characteristics.

  10. Implications of Thyroglobulin Antibody Positivity in Patients with Differentiated Thyroid Cancer

    DEFF Research Database (Denmark)

    Verburg, Frederik A; Luster, Markus; Cupini, Cristina

    2013-01-01

    Background: Even though the presence of antithyroglobulin antibodies (TgAbs) represents a significant problem in the follow-up of patients with differentiated thyroid cancer (DTC), the current guidelines on the management of DTC that have been published in recent years contain no text concerning...... the methods to be used for detecting such antibody-related interference in thyroglobulin (Tg) measurement or how to manage TgAb-positive patients in whom Tg cannot be used reliably as a tumor marker. Aim: An international group of experts from the European Thyroid Association Cancer Research Network who...... insufficient evidence was available, a thorough discussion by a group of physician-scientists, all of whom have a distinguished track record in thyroid cancer care, was held to arrive at a consensus expert opinion. The questions and answers discussed were then summarized into an algorithm for the management...

  11. Differential susceptibility in youth : evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'

    NARCIS (Netherlands)

    Hankin, B.L.; Nederhof, E.; Oppenheimer, C.W.; Jenness, J.; Young, J.F.; Abela, J.R.Z.; Smolen, A.; Ormel, J.; Oldehinkel, A.J.

    2011-01-01

    Positive affect has been implicated in the phenomenological experience of various psychiatric disorders, vulnerability to develop psychopathology and overall socio-emotional functioning. However, developmental influences that may contribute to positive affect have been understudied. Here, we studied

  12. Quantification of Competitive Game Demands of NCAA Division I College Football Players Using Global Positioning Systems.

    Science.gov (United States)

    Wellman, Aaron D; Coad, Sam C; Goulet, Grant C; McLellan, Christopher P

    2016-01-01

    The aim of the present study was to examine the competitive physiological movement demands of National Collegiate Athletic Association (NCAA) Division I college football players using portable global positioning system (GPS) technology during games and to examine positional groups within offensive and defensive teams, to determine if a player's physiological requirements during games are influenced by playing position. Thirty-three NCAA Division I Football Bowl Subdivision football players were monitored using GPS receivers with integrated accelerometers (GPSports) during 12 regular season games throughout the 2014 season. Individual data sets (n = 295) from players were divided into offensive and defensive teams and subsequent position groups. Movement profile characteristics, including total, low-intensity, moderate-intensity, high-intensity, and sprint running distances (m), sprint counts, and acceleration and deceleration efforts, were assessed during games. A one-way ANOVA and post-hoc Bonferroni statistical analysis were used to determine differences in movement profiles between each position group within offensive and defensive teams. For both offensive and defensive teams, significant (p ≤ 0.05) differences exist between positional groups for game physical performance requirements. The results of the present study identified that wide receivers and defensive backs completed significantly (p ≤ 0.05) greater total distance, high-intensity running, sprint distance, and high-intensity acceleration and deceleration efforts than their respective offensive and defensive positional groups. Data from the present study provide novel quantification of position-specific physical demands of college football games and support the use of position-specific training in the preparation of NCAA Division I college football players for competition.

  13. Negative parenting behavior and childhood oppositional defiant disorder: differential moderation by positive and negative peer regard.

    Science.gov (United States)

    Tung, Irene; Lee, Steve S

    2014-01-01

    Although negative parenting behavior and peer status are independently associated with childhood conduct problems (e.g., oppositional defiant disorder (ODD)), relatively little is known about their interplay, particularly in relation to differentiated measures of positive and negative peer regard. To improve the specificity of the association of negative parenting behavior and peer factors with ODD, we explored the potential interaction of parenting and peer status in a sample of 169 five-to ten-year-old ethnically diverse children with and without attention-deficit/hyperactivity disorder (ADHD) assessed using multiple measures (i.e., rating scales, interview) and informants (i.e., parents, teachers). Controlling for children's age, sex, number of ADHD symptoms, and parents' race-ethnicity, peer acceptance inversely predicted and inconsistent discipline, harsh punishment, and peer rejection were each positively associated with ODD symptom severity. Interactive influences were also evident such that inconsistent discipline and harsh punishment each predicted elevated ODD but only among children experiencing low peer acceptance or high peer rejection. These findings suggest that supportive environments, including peer acceptance, may protect children from negative outcomes associated with inconsistent discipline and harsh punishment. Findings are integrated with theories of social support, and we additionally consider implications for intervention and prevention. © 2013 Wiley Periodicals, Inc.

  14. Photogrammetric and Global Positioning System Measurements of Active Pahoehoe Lava Lobe Emplacement on Kilauea, Hawaii

    Science.gov (United States)

    Hamilton, Christopher W.; Glaze, Lori S.; James, Mike R.; Baloga, Stephen M.; Fagents, Sarah A.

    2012-01-01

    Basalt is the most common rock type on the surface of terrestrial bodies throughout the solar system and -- by total volume and areal coverage -- pahoehoe flows are the most abundant form of basaltic lava in subaerial and submarine environments on Earth. A detailed understanding of pahoehoe emplacement processes is necessary for developing accurate models of flow field development, assessing hazards associated with active lava flows, and interpreting the significance of lava flow morphology on Earth and other planetary bodies. Here, we examine the active emplacement of pahoehoe lobes along the margins of the Hook Flow from Pu'u 'O'o on Kilauea, Hawaii. Topographic data were acquired between 21 and 23 February 2006 using stereo-imaging and differential global positing system (DGPS) measurements. During this time, the average discharge rate for the Hook Flow was 0.01-0.05 cubic m/s. Using stereogrammetric point clouds and interpolated digital terrain models (DTMs), active flow fronts were digitized at 1 minute intervals. These areal spreading maps show that the lava lobe grew by a series of breakouts tha t broadly fit into two categories: narrow (0.2-0.6 m-wide) toes that grew preferentially down-slope, and broad (1.4-3.5 m-wide) breakouts that formed along the sides of the lobe, nearly perpendicular to the down-flow axis. These lobes inflated to half of their final thickness within approx 5 minutes, with a rate of inflation that generally deceased with time. Through a combination of down-slope and cross-slope breakouts, lobes developed a parabolic cross-sectional shape within tens of minutes. We also observed that while the average local discharge rate for the lobe was generally constant at 0.0064 +/- 0.0019 cubic m/s, there was a 2 to 6 fold increase in the areal coverage rate every 4.1 +/- 0.6 minutes. We attribute this periodicity to the time required for the dynamic pressurization of the liquid core of the lava lobe to exceed the cooling-induced strength of the

  15. MTV's "Staying Alive" global campaign promoted interpersonal communication about HIV and positive beliefs about HIV prevention.

    Science.gov (United States)

    Geary, Cynthia Waszak; Burke, Holly McClain; Castelnau, Laure; Neupane, Shailes; Sall, Yacine Ba; Wong, Emily; Tucker, Heidi Toms

    2007-02-01

    In 2002 MTV launched a global multicomponent HIV prevention campaign, "Staying Alive," reaching over 166 countries worldwide. An evaluation of this campaign focused on three diverse sites: Kathmandu, Nepal; São Paulo, Brazil; and Dakar, Senegal. Data were collected before and after campaign implementation through population-based household surveys. Using linear regression techniques, our evaluation examined the effects of campaign exposure on interpersonal communication about HIV and the effects of campaign exposure and interpersonal communication on beliefs about HIV prevention. We found a consistent positive effect of exposure on interpersonal communication across all sites, though there were differences among sites with regard to whom the respondent talked about HIV. We also found a consistent positive effect of exposure on HIV prevention beliefs across sites when interpersonal communication was simultaneously entered into the model. Finally, in two sites we found a relationship between interpersonal communication and HIV prevention beliefs, controlling for exposure, though again, the effects differed by the type of person the communication was with. These similar findings in three diverse sites provide ecological validity of the findings that "Staying Alive" promoted interpersonal communication and influenced young people's beliefs about HIV prevention in a positive way, evidence for the potential of a global media campaign to have an impact on social norms.

  16. Geometrically constrained kinematic global navigation satellite systems positioning: Implementation and performance

    Science.gov (United States)

    Asgari, Jamal; Mohammadloo, Tannaz H.; Amiri-Simkooei, Ali Reza

    2015-09-01

    GNSS kinematic techniques are capable of providing precise coordinates in extremely short observation time-span. These methods usually determine the coordinates of an unknown station with respect to a reference one. To enhance the precision, accuracy, reliability and integrity of the estimated unknown parameters, GNSS kinematic equations are to be augmented by possible constraints. Such constraints could be derived from the geometric relation of the receiver positions in motion. This contribution presents the formulation of the constrained kinematic global navigation satellite systems positioning. Constraints effectively restrict the definition domain of the unknown parameters from the three-dimensional space to a subspace defined by the equation of motion. To test the concept of the constrained kinematic positioning method, the equation of a circle is employed as a constraint. A device capable of moving on a circle was made and the observations from 11 positions on the circle were analyzed. Relative positioning was conducted by considering the center of the circle as the reference station. The equation of the receiver's motion was rewritten in the ECEF coordinates system. A special attention is drawn onto how a constraint is applied to kinematic positioning. Implementing the constraint in the positioning process provides much more precise results compared to the unconstrained case. This has been verified based on the results obtained from the covariance matrix of the estimated parameters and the empirical results using kinematic positioning samples as well. The theoretical standard deviations of the horizontal components are reduced by a factor ranging from 1.24 to 2.64. The improvement on the empirical standard deviation of the horizontal components ranges from 1.08 to 2.2.

  17. The Effect of IMF Fluctuations on the SubsolarMagnetopause Position Using a Global MHD Model

    Science.gov (United States)

    Bonde, R. E. F.; Lopez, R. E.; Wang, J.; Carranza, H.

    2017-12-01

    During southward interplanetary magnetic field (IMF) conditions, the subsolar magnetopause moves inward. This is generally referred to as "erosion." Studies have been conducted on such magnetopause erosion; however, they generally use steady state IMF conditions. Solar wind conditions are not usually constant for very long, especially during such conditions as are present in high-speeds streams, which typically have large fluctuations in the IMF. These IMF fluctuations can occur on a range of times scales and amplitudes, resulting in a series of northward and southward IMF intervals imposed on the magnetosphere. We simulate the effect of such IMF variations on the magnetopause position using a global MHD model. We will present the dependence of the subsolar magnetopause position on the frequency and amplitude of IMF oscillations.

  18. Positive feedback between global warming and atmospheric CO2 concentration inferred from past climate change

    Science.gov (United States)

    Scheffer, Marten; Brovkin, Victor; Cox, Peter M.

    2006-05-01

    There is good evidence that higher global temperatures will promote a rise of greenhouse gas levels, implying a positive feedback which will increase the effect of anthropogenic emissions on global temperatures. However, the magnitude of this effect predicted by the available models remains highly uncertain, due to the accumulation of uncertainties in the processes thought to be involved. Here we present an alternative way of estimating the magnitude of the feedback effect based on reconstructed past changes. Linking this information with the mid-range Intergovernmental Panel on Climate Change estimation of the greenhouse gas effect on temperature we suggest that the feedback of global temperature on atmospheric CO2 will promote warming by an extra 15-78% on a century-scale. This estimate may be conservative as we did not account for synergistic effects of likely temperature moderated increase in other greenhouse gases. Our semi-empirical approach independently supports process based simulations suggesting that feedback may cause a considerable boost in warming.

  19. Differential imprints of different ENSO flavors in global patterns of seasonal precipitation extremes

    Science.gov (United States)

    Wiedermann, Marc; Siegmund, Jonatan F.; Donges, Jonathan F.; Donner, Reik V.

    2017-04-01

    The El Nino Southern Oscillation (ENSO) with its positive (El Nino) and negative (La Nina) phases is known to trigger climatic responses in various parts of the Earth, an effect commonly attributed to teleconnectivity. A series of studies has demonstrated that El Nino periods exhibits a relatively broad variety of spatial patterns, which can be classified into two main flavors termed East Pacific (EP, canonical) and Central Pacific (CP, Modoki) El Nino, and that both subtypes can trigger distinct climatic responses like droughts vs. precipitation increases at the regional level. More recently, a similar discrimination of La Nina periods into two different flavors has been reported, and it is reasonable to assume that these different expressions are equally accompanied by differential responses of regional climate variability in particularly affected regions. In this work, we study in great detail the imprints of both types of El Nino and La Nina periods in extremal seasonal precipitation sums during fall (SON), winter (DJF) and spring (MAM) around the peak time of the corresponding ENSO phase. For this purpose, we employ a recently developed objective classification of El Nino and La Nina periods into their two respective flavors based on global teleconnectivity patterns in daily surface air temperature anomalies as captured by the associated climate network representations (Wiedermann et al., 2016). In order to study the statistical relevance of the timing of different El Nino and La Nina types on that of seasonal precipitation extremes around the globe (according to the GPCC data set as a reference), we utilize event coincidence analysis (Donges et al., 2016), a new powerful yet conceptually simple and intuitive statistical tool that allows quantifying the degree of simultaneity of distinct events in pairs of time series. Our results provide a comprehensive overview on ENSO related imprints in regional seasonal precipitation extremes. We demonstrate that key

  20. Ambiguity resolution in precise point positioning with hourly data for global single receiver

    Science.gov (United States)

    Zhang, Xiaohong; Li, Pan; Guo, Fei

    2013-01-01

    Integer ambiguity resolution (IAR) can improve precise point positioning (PPP) performance significantly. IAR for PPP became a highlight topic in global positioning system (GPS) community in recent years. More and more researchers focus on this issue. Progress has been made in the latest years. In this paper, we aim at investigating and demonstrating the performance of a global zero-differenced (ZD) PPP IAR service for GPS users by providing routine ZD uncalibrated fractional offsets (UFOs) for wide-lane and narrow-lane. Data sets from all IGS stations collected on DOY 1, 100, 200 and 300 of 2010 are used to validate and demonstrate this global service. Static experiment results show that an accuracy better than 1 cm in horizontal and 1-2 cm in vertical could be achieved in ambiguity-fixed PPP solution with only hourly data. Compared with PPP float solution, an average improvement reaches 58.2% in east, 28.3% in north and 23.8% in vertical for all tested stations. Results of kinematic experiments show that the RMS of kinematic PPP solutions can be improved from 21.6, 16.6 and 37.7 mm to 12.2, 13.3 and 34.3 mm for the fixed solutions in the east, north and vertical components, respectively. Both static and kinematic experiments show that wide-lane and narrow-lane UFO products of all satellites can be generated and provided in a routine way accompanying satellite orbit and clock products for the PPP user anywhere around the world, to obtain accurate and reliable ambiguity-fixed PPP solutions.

  1. Placental Kisspeptins Differentially Modulate Vital Parameters of Estrogen Receptor-Positive and -Negative Breast Cancer Cells

    Science.gov (United States)

    Rasoulzadeh, Zahra; Ghods, Roya; Kazemi, Tohid; Mirzadegan, Ebrahim; Ghaffari-Tabrizi-Wizsy, Nassim; Rezania, Simin; Kazemnejad, Somaieh; Arefi, Soheila; Ghasemi, Jamileh; Vafaei, Sedigheh; Mahmoudi, Ahmad-Reza; Zarnani, Amir-Hassan

    2016-01-01

    Kisspeptins (KPs) are major regulators of trophoblast and cancer invasion. Thus far, limited and conflicting data are available on KP-mediated modulation of breast cancer (BC) metastasis; mostly based on synthetic KP-10, the most active fragment of KP. Here, we report for the first time comprehensive functional effects of term placental KPs on proliferation, adhesion, Matrigel invasion, motility, MMP activity and pro-inflammatory cytokine production in MDA-MB-231 (estrogen receptor-negative) and MCF-7 (estrogen receptor-positive). KPs were expressed at high level by term placental syncytiotrophoblasts and released in soluble form. Placental explant conditioned medium containing KPs (CM) significantly reduced proliferation of both cell types compared to CM without (w/o) KP (CM-w/o KP) in a dose- and time-dependent manner. In MDA-MB-231 cells, placental KPs significantly reduced adhesive properties, while increased MMP9 and MMP2 activity and stimulated invasion. Increased invasiveness of MDA-MB-231 cells after CM treatment was inhibited by KP receptor antagonist, P-234. CM significantly reduced motility of MCF-7 cells at all time points (2–30 hr), while it stimulated motility of MDA-MB-231 cells. These effects were reversed by P-234. Co-treatment with selective ER modulators, Tamoxifen and Raloxifene, inhibited the effect of CM on motility of MCF-7 cells. The level of IL-6 in supernatant of MCF-7 cells treated with CM was higher compared to those treated with CM-w/o KP. Both cell types produced more IL-8 after treatment with CM compared to those treated with CM-w/o KP. Taken together, our observations suggest that placental KPs differentially modulate vital parameters of estrogen receptor-positive and -negative BC cells possibly through modulation of pro-inflammatory cytokine production. PMID:27101408

  2. Diagnostic Usefulness of Differential Time to Positivity for Catheter-Related Candidemia

    Science.gov (United States)

    Park, Ki-Ho; Lee, Mi Suk; Lee, Sang-Oh; Choi, Sang-Ho; Sung, Heungsup; Kim, Mi-Na; Kim, Yang Soo; Woo, Jun Hee

    2014-01-01

    A differential time to positivity (DTP) of ≥120 min is useful for diagnosing catheter-related bacteremia, but data on diagnosing catheter-related candidemia (CRC) in this way are limited. We wished to evaluate the usefulness of the DTP for diagnosing CRC. All adult patients who had the same Candida species isolated from blood cultures drawn simultaneously from a central venous catheter (CVC) and a peripheral vein were included at a tertiary care hospital over an 18-month period. A total of 105 patients with candidemia who had positive simultaneous CVC and peripheral vein blood cultures were included in our study. Sixty-one patients (58%) had CRC (47 definite and 14 probable), and 38 (36%) had candidemia from another source (non-CRC). The remaining 6 patients (6%) with indeterminate candidemia were excluded from the final analysis. The overall sensitivity and specificity of a DTP of ≥120 min for diagnosing CRC were 85% (95% confidence interval [CI], 74% to 93%) and 82% (95% CI, 66% to 92%), respectively, and for neutropenic patients, they were 75% (95% CI, 19% to 99%) and 100% (95% CI, 75% to 100%), respectively. For Candida glabrata infections, the optimal DTP cutoff was ≥6 h, with a sensitivity of 63% (95% CI, 35% to 85%) and a specificity of 75% (95% CI, 35% to 97%). In summary, DTP is useful for diagnosing CRC, and a DTP of ≥120 min appears to be the optimal cutoff except for CRC caused by C. glabrata. For neutropenic patients, DTP may be useful as an adjunct test to rule in CRC and to decide whether a catheter should be removed. PMID:24829236

  3. Accuracy of Kinematic Positioning Using Global Satellite Navigation Systems under Forest Canopies

    Directory of Open Access Journals (Sweden)

    Harri Kaartinen

    2015-09-01

    Full Text Available A harvester enables detailed roundwood data to be collected during harvesting operations by means of the measurement apparatus integrated into its felling head. These data can be used to improve the efficiency of wood procurement and also replace some of the field measurements, and thus provide both less costly and more detailed ground truth for remote sensing based forest inventories. However, the positional accuracy of harvester-collected tree data is not sufficient currently to match the accuracy per individual trees achieved with remote sensing data. The aim in the present study was to test the accuracy of various instruments utilizing global satellite navigation systems (GNSS in motion under forest canopies of varying densities to enable us to get an understanding of the current state-of-the-art in GNSS-based positioning under forest canopies. Tests were conducted using several different combinations of GNSS and inertial measurement unit (IMU mounted on an all-terrain vehicle (ATV “simulating” a moving harvester. The positions of 224 trees along the driving route were measured using a total-station and real-time kinematic GPS. These trees were used as reference items. The position of the ATV was obtained using GNSS and IMU with an accuracy of 0.7 m (root mean squared error (RMSE for 2D positions. For the single-frequency GNSS receivers, the RMSE of real-time 2D GNSS positions was 4.2–9.3 m. Based on these results, it seems that the accuracy of novel single-frequency GNSS devices is not so dependent on forest conditions, whereas the performance of the tested geodetic dual-frequency receiver is very sensitive to the visibility of the satellites. When post-processing can be applied, especially when combined with IMU data, the improvement in the accuracy of the dual-frequency receiver was significant.

  4. Wealth, Poverty, and Happiness: Social Class Is Differentially Associated With Positive Emotions.

    Science.gov (United States)

    Piff, Paul K; Moskowitz, Jake P

    2017-12-18

    Is higher social class associated with greater happiness? In a large nationally representative U.S. sample (N = 1,519), we examined the association between social class (household income) and self-reported tendencies to experience 7 distinct positive emotions that are core to happiness: amusement, awe, compassion, contentment, enthusiasm, love, and pride. Consistent with past research indicating that social class underlies differential patterns of attending to the self versus orienting to others, higher social class was associated with greater self-oriented feelings of contentment and pride, and with greater amusement. In contrast, lower social class was associated with more other-oriented feelings of compassion and love, and with greater awe. There were no class differences in enthusiasm. We discuss that individuals from different social class backgrounds may exhibit different patterns of emotional responding due to their distinct social concerns and priorities. Whereas self-oriented emotions may follow from, foster, and reinforce upper class individuals' desire for independence and self-sufficiency, greater other-oriented emotion may enable lower class individuals to form more interdependent bonds to cope with their more threatening environments. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  5. Differential Amplitude Pulse-Position Modulation for Indoor Wireless Optical Communications

    Directory of Open Access Journals (Sweden)

    Sethakaset Ubolthip

    2005-01-01

    Full Text Available We propose a novel differential amplitude pulse-position modulation (DAPPM for indoor optical wireless communications. DAPPM yields advantages over PPM, DPPM, and DH-PIM in terms of bandwidth requirements, capacity, and peak-to-average power ratio (PAPR. The performance of a DAPPM system with an unequalized receiver is examined over nondispersive and dispersive channels. DAPPM can provide better bandwidth and/or power efficiency than PAM, PPM, DPPM, and DH-PIM depending on the number of amplitude levels and the maximum length of a symbol. We also show that, given the same maximum length, DAPPM has better bandwidth efficiency but requires about and more power than PPM and DPPM, respectively, at high bit rates over a dispersive channel. Conversely, DAPPM requires less power than DH-PIM . When the number of bits per symbol is the same, PAM requires more power, and DH-PIM less power, than DAPPM. Finally, it is shown that the performance of DAPPM can be improved with MLSD, chip-rate DFE, and multichip-rate DFE.

  6. Higher-order stochastic differential equations and the positive Wigner function

    Science.gov (United States)

    Drummond, P. D.

    2017-12-01

    General higher-order stochastic processes that correspond to any diffusion-type tensor of higher than second order are obtained. The relationship of multivariate higher-order stochastic differential equations with tensor decomposition theory and tensor rank is explained. Techniques for generating the requisite complex higher-order noise are proved to exist either using polar coordinates and γ distributions, or from products of Gaussian variates. This method is shown to allow the calculation of the dynamics of the Wigner function, after it is extended to a complex phase space. The results are illustrated physically through dynamical calculations of the positive Wigner distribution for three-mode parametric downconversion, widely used in quantum optics. The approach eliminates paradoxes arising from truncation of the higher derivative terms in Wigner function time evolution. Anomalous results of negative populations and vacuum scattering found in truncated Wigner quantum simulations in quantum optics and Bose-Einstein condensate dynamics are shown not to occur with this type of stochastic theory.

  7. On convergence of differential evolution over a class of continuous functions with unique global optimum.

    Science.gov (United States)

    Ghosh, Sayan; Das, Swagatam; Vasilakos, Athanasios V; Suresh, Kaushik

    2012-02-01

    Differential evolution (DE) is arguably one of the most powerful stochastic real-parameter optimization algorithms of current interest. Since its inception in the mid 1990s, DE has been finding many successful applications in real-world optimization problems from diverse domains of science and engineering. This paper takes a first significant step toward the convergence analysis of a canonical DE (DE/rand/1/bin) algorithm. It first deduces a time-recursive relationship for the probability density function (PDF) of the trial solutions, taking into consideration the DE-type mutation, crossover, and selection mechanisms. Then, by applying the concepts of Lyapunov stability theorems, it shows that as time approaches infinity, the PDF of the trial solutions concentrates narrowly around the global optimum of the objective function, assuming the shape of a Dirac delta distribution. Asymptotic convergence behavior of the population PDF is established by constructing a Lyapunov functional based on the PDF and showing that it monotonically decreases with time. The analysis is applicable to a class of continuous and real-valued objective functions that possesses a unique global optimum (but may have multiple local optima). Theoretical results have been substantiated with relevant computer simulations.

  8. The Impact of Satellite Time Group Delay and Inter-Frequency Differential Code Bias Corrections on Multi-GNSS Combined Positioning.

    Science.gov (United States)

    Ge, Yulong; Zhou, Feng; Sun, Baoqi; Wang, Shengli; Shi, Bo

    2017-03-16

    We present quad-constellation (namely, GPS, GLONASS, BeiDou and Galileo) time group delay (TGD) and differential code bias (DCB) correction models to fully exploit the code observations of all the four global navigation satellite systems (GNSSs) for navigation and positioning. The relationship between TGDs and DCBs for multi-GNSS is clearly figured out, and the equivalence of TGD and DCB correction models combining theory with practice is demonstrated. Meanwhile, the TGD/DCB correction models have been extended to various standard point positioning (SPP) and precise point positioning (PPP) scenarios in a multi-GNSS and multi-frequency context. To evaluate the effectiveness and practicability of broadcast TGDs in the navigation message and DCBs provided by the Multi-GNSS Experiment (MGEX), both single-frequency GNSS ionosphere-corrected SPP and dual-frequency GNSS ionosphere-free SPP/PPP tests are carried out with quad-constellation signals. Furthermore, the author investigates the influence of differential code biases on GNSS positioning estimates. The experiments show that multi-constellation combination SPP performs better after DCB/TGD correction, for example, for GPS-only b1-based SPP, the positioning accuracies can be improved by 25.0%, 30.6% and 26.7%, respectively, in the N, E, and U components, after the differential code biases correction, while GPS/GLONASS/BDS b1-based SPP can be improved by 16.1%, 26.1% and 9.9%. For GPS/BDS/Galileo the 3rd frequency based SPP, the positioning accuracies are improved by 2.0%, 2.0% and 0.4%, respectively, in the N, E, and U components, after Galileo satellites DCB correction. The accuracy of Galileo-only b1-based SPP are improved about 48.6%, 34.7% and 40.6% with DCB correction, respectively, in the N, E, and U components. The estimates of multi-constellation PPP are subject to different degrees of influence. For multi-constellation combination SPP, the accuracy of single-frequency is slightly better than that of dual

  9. On stochastic modeling of the modernized global positioning system (GPS) L2C signal

    International Nuclear Information System (INIS)

    Elsobeiey, Mohamed; El-Rabbany, Ahmed

    2010-01-01

    In order to take full advantage of the modernized GPS L2C signal, it is essential that its stochastic characteristics and code bias be rigorously determined. In this paper, long sessions of GPS measurements are used to study the stochastic characteristics of the modernized GPS L2C signal. As a byproduct, the stochastic characteristics of the legacy GPS signals, namely C/A and P2 codes, are also determined, which are used to verify the developed stochastic model of the modernized signal. The differential code biases between P2 and C2, DCB P2-C2 , are also estimated using the Bernese GPS software. It is shown that the developed models improved the precise point positioning (PPP) solution and convergence time

  10. Match-play demands of elite youth Gaelic football using global positioning system tracking.

    Science.gov (United States)

    Reilly, Brian; Akubat, Ibrahim; Lyons, Mark; Collins, D Kieran

    2015-04-01

    Global positioning systems (GPS) technology has made athlete-tracking a convenient and accepted technique to specify movement patterns and physical demands in sport. The purpose of this study was to examine positional demands of elite youth Gaelic football match-play using portable GPS technology to examine movement patterns and heart rates across match periods. Fifty-six elite youth male Gaelic footballers (age, 15 ± 0.66 years) fitted with portable 4-Hz GPS units were observed during 6 competitive matches (60 minutes). Data provided from the GPS unit included total distance, high-intensity (≥17·km·h(-1)) distance, sprint (≥22 km·h(-1)) distance, and total number of sprints. Heart rate was monitored continuously throughout the games. Players covered a mean distance of 5732 ± 1047 m, and the mean intensity of match-play was 85% of the peak heart rate. There was a significant (p = 0.028) drop in the total distance covered in the second half (2783 ± 599 m) compared with the first half (2948 ± 580 m). In particular, there is a noticeable drop in the distance covered in the third quarter of the game (after half-time), which has implications for re-warming up at the end of the half-time interval. There was a highly significant (p < .001) difference in the distance traveled across the 5 positional groups with midfielders covering the greatest total distance (6740 ± 384 m). The significant differences found with respect to positional groups support the implementation of individual, position-specific strength and conditioning programs.

  11. Some tests of wet tropospheric calibration for the CASA Uno Global Positioning System experiment

    Science.gov (United States)

    Dixon, T. H.; Wolf, S. Kornreich

    1990-01-01

    Wet tropospheric path delay can be a major error source for Global Positioning System (GPS) geodetic experiments. Strategies for minimizing this error are investigted using data from CASA Uno, the first major GPS experiment in Central and South America, where wet path delays may be both high and variable. Wet path delay calibration using water vapor radiometers (WVRs) and residual delay estimation is compared with strategies where the entire wet path delay is estimated stochastically without prior calibration, using data from a 270-km test baseline in Costa Rica. Both approaches yield centimeter-level baseline repeatability and similar tropospheric estimates, suggesting that WVR calibration is not critical for obtaining high precision results with GPS in the CASA region.

  12. FirstAED emergency dispatch, global positioning of community first responders with distinct roles

    DEFF Research Database (Denmark)

    Henriksen, Finn Lund; Schorling, Per; Hansen, Bruno

    2016-01-01

    their roles in a team structure to reduce response times, ensure citizens' safety and offer equal possibility of early defibrillation. First aid is provided by community first responders who use their smartphone. FirstAED global positioning system (GPS)-tracks the nine nearby first responders and enables......FirstAED is a supplement to the existing emergency response systems. The aim is to shorten the community first responder response times at emergency calls to below five minutes in a bridge connected island area. FirstAED defines a way to dispatch the nearby three first responders and organise...... the emergency dispatcher to send an organised team of three first responders with distinct roles to the scene automatically. During the first 24 months the FirstAED system was used 718 times. Three first responders arrived in ∼89% of the cases, and they arrived before the ambulance in ∼94% of the cases. First...

  13. On the measurement of the neutrino velocity applying the standard time of the Global Positioning System

    Science.gov (United States)

    Skeivalas, J.; Parseliunas, E.

    2013-01-01

    The measurement of the neutrino velocity applying the standard time of the Global Positioning System (GPS) is presented in the paper. The practical data were taken from the OPERA experiment, in which neutrino emission from the CERN LHC accelerator to Gran Sasso detector was investigated. The distance between accelerator and detector is about 730 km. The time interval was measured by benchmark clocks, which were calibrated by the standard GPS time signals received from GPS satellites. The calculation of the accuracy of the GPS time signals with respect to changes of the signals' frequencies due to the Doppler effect is presented. It is shown that a maximum error of about 200 ns could occur when GPS time signals are applied for the calibration of the clocks for the neutrino velocity measurements.

  14. IMPELEMENTASI SISTEM PEMANTAUAN OBJEK BERGERAK DENGAN MEMANFAATKAN FREKUENSI RADIO MENGGUNAKAN GPS (GLOBAL POSITIONING SYSTEM

    Directory of Open Access Journals (Sweden)

    Budi Triandi

    2010-05-01

    Full Text Available GPS was developed by the United States Department of Defense as a reliable means for accurate navigation. The system provides highly accurate position and velocity information and precise time on a continuous global basis to an unlimited number of properly equipped users. By using combined GPS receiver and microcontroller together with radio system, we can design a monitoring system for our vehicles and display the result on the computer. This system consists of a master module that transmits and receives signals from computer and two slave modules to collect GPS data from vehicles. The result of experiment shows that this system is able to track the vehicle on digital map with accuracy as high as 95%.Keywords: GPS, microcontroller, monitoring, RF

  15. Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference.

    Science.gov (United States)

    Gan, Emily Y; Eleftheriadou, Viktoria; Esmat, Samia; Hamzavi, Iltefat; Passeron, Thierry; Böhm, Markus; Anbar, Tag; Goh, Boon Kee; Lan, Cheng-Che E; Lui, Harvey; Ramam, M; Raboobee, Noufal; Katayama, Ichiro; Suzuki, Tamio; Parsad, Davinder; Seth, Vaneeta; Lim, Henry W; van Geel, Nanja; Mulekar, Sanjeev; Harris, John; Wittal, Richard; Benzekri, Laila; Gauthier, Yvon; Kumarasinghe, Prasad; Thng, Steven T G; Silva de Castro, Caio Cesar; Abdallah, Marwa; Vrijman, Charlotte; Bekkenk, Marcel; Seneschal, Julien; Pandya, Amit G; Ezzedine, Khaled; Picardo, Mauro; Taïeb, Alain

    2017-01-01

    The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr. Treatment is defined as successful if repigmentation exceeds 80% and at least 80% of the gained repigmentation is maintained for over 6 months. No agreement was found on the best outcome measure for assessing target or global repigmentation, therefore highlighting the limitations of e-surveys in addressing clinical measurements. Until there is a clear consensus, existing tools should be selected according to the specific needs of each study. A workshop will be conducted to address the remaining issues so as to achieve a consensus. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Global genetic differentiation in a cosmopolitan pest of stored beans: effects of geography, host-plant usage and anthropogenic factors.

    Science.gov (United States)

    Tuda, Midori; Kagoshima, Kumiko; Toquenaga, Yukihiko; Arnqvist, Göran

    2014-01-01

    Genetic differentiation can be promoted allopatrically by geographic isolation of populations due to limited dispersal ability and diversification over time or sympatrically through, for example, host-race formation. In crop pests, the trading of crops across the world can lead to intermixing of genetically distinct pest populations. However, our understanding of the importance of allopatric and sympatric genetic differentiation in the face of anthropogenic genetic intermixing is limited. Here, we examined global sequence variation in two mitochondrial and one nuclear genes in the seed beetle Callosobruchus maculatus that uses different legumes as hosts. We analyzed 180 samples from 42 populations of this stored bean pest from tropical and subtropical continents and archipelagos: Africa, the Middle East, South and Southeast Asia, Oceania and South America. For the mitochondrial genes, there was weak but significant genetic differentiation across continents/archipelagos. Further, we found pronounced differentiation among subregions within continents/archipelagos both globally and within Africa but not within Asia. We suggest that multiple introductions into Asia and subsequent intermixing within Asia have generated this pattern. The isolation by distance hypothesis was supported globally (with or without continents controlled) but not when host species was restricted to cowpeas Vigna unguiculata, the ancestral host of C. maculatus. We also document significant among-host differentiation both globally and within Asia, but not within Africa. We failed to reject a scenario of a constant population size in the recent past combined with selective neutrality for the mitochondrial genes. We conclude that mitochondrial DNA differentiation is primarily due to geographic isolation within Africa and to multiple invasions by different alleles, followed by host shifts, within Asia. The weak inter-continental differentiation is most likely due to frequent inter-continental gene

  17. When Agony Begets Zealotry: The Differential Role of Globalization Threats in Mediating the Effect of Competitive Victimhood on Muslims’ Religious Fundamentalism

    NARCIS (Netherlands)

    Mashuri, A.; Zaduqisti, Esti; Sakdiah, Halimatus; Sukmawati, Fitri

    2015-01-01

    The current investigations examine how globalization signifying either identity threat or realistic threat has a differential role in mediating the effect of competitive victimhood on Muslims’ religious fundamentalism. Study 1 ( N= 119) revealed that identity globalization threat and not realistic

  18. Global differential gene expression in response to growth temperature alteration in group A Streptococcus.

    Science.gov (United States)

    Smoot, L M; Smoot, J C; Graham, M R; Somerville, G A; Sturdevant, D E; Migliaccio, C A; Sylva, G L; Musser, J M

    2001-08-28

    Pathogens are exposed to different temperatures during an infection cycle and must regulate gene expression accordingly. However, the extent to which virulent bacteria alter gene expression in response to temperatures encountered in the host is unknown. Group A Streptococcus (GAS) is a human-specific pathogen that is responsible for illnesses ranging from superficial skin infections and pharyngitis to severe invasive infections such as necrotizing fasciitis and streptococcal toxic shock syndrome. GAS survives and multiplies at different temperatures during human infection. DNA microarray analysis was used to investigate the influence of temperature on global gene expression in a serotype M1 strain grown to exponential phase at 29 degrees C and 37 degrees C. Approximately 9% of genes were differentially expressed by at least 1.5-fold at 29 degrees C relative to 37 degrees C, including genes encoding transporter proteins, proteins involved in iron homeostasis, transcriptional regulators, phage-associated proteins, and proteins with no known homologue. Relatively few known virulence genes were differentially expressed at this threshold. However, transcription of 28 genes encoding proteins with predicted secretion signal sequences was altered, indicating that growth temperature substantially influences the extracellular proteome. TaqMan real-time reverse transcription-PCR assays confirmed the microarray data. We also discovered that transcription of genes encoding hemolysins, and proteins with inferred roles in iron regulation, transport, and homeostasis, was influenced by growth at 40 degrees C. Thus, GAS profoundly alters gene expression in response to temperature. The data delineate the spectrum of temperature-regulated gene expression in an important human pathogen and provide many unforeseen lines of pathogenesis investigation.

  19. Office-based differential diagnosis of transient and persistent geotropic positional nystagmus in patients with horizontal canal type of benign paroxysmal positional vertigo.

    Science.gov (United States)

    Okazaki, Suzuyo; Imai, Takao; Higashi-Shingai, Kayoko; Matsuda, Kazunori; Takeda, Noriaki; Kitahara, Tadashi; Uno, Atsuhiko; Horii, Arata; Ohta, Yumi; Morihana, Tetsuo; Masumura, Chisako; Nishiike, Suetaka; Inohara, Hidenori

    2017-03-01

    A 30 s observation of geotropic positional nystagmus is sufficient to distinguish persistent geotropic positional nystagmus (PGPN) from transient geotropic positional nystagmus (TGPN) in patients with horizontal canal type of benign paroxysmal positional vertigo (H-BPPV) in ENT office. As a canalith repositioning procedure effectively treats H-BPPV with TGPN, but not PGPN, the differentiation between patients with PGPN and with TGPN is essential. The purpose of this study is to determine the observation period enough to distinguish TGPN from PGPN. This study first analyzed positional nystagmus images recorded with an infrared CCD camera three-dimensionally in 47 patients with H-BPPV. PGPN is distinguished from TGPN in patients with H-BPPV precisely by means of time constant calculated form analysis of positional nystagmus. Ten-second and 30-s movies were made of positional nystagmus of the all 47 patients. Ten independent otolaryngologists were then asked to distinguish TGPN from PGPN after a 10 s or 30 s observation of the geotropic positional nystagmus images in 47 patients with H-BPPV. The sensitivity and specificity to distinguish TGPN from PGPN was 100% and 97% after 30 s observation, but 100% and 40% after 10 s observation, respectively.

  20. Global convergence of successive approximations of the Darboux problem for partial functional differential equations with infinite delay

    Directory of Open Access Journals (Sweden)

    Tomasz Człapiński

    2014-01-01

    Full Text Available We consider the Darboux problem for the hyperbolic partial functional differential equation with infinite delay. We deal with generalized (in the "almost everywhere" sense solutions of this problem. We prove a theorem on the global convergence of successive approximations to a unique solution of the Darboux problem.

  1. The Validity and Reliability of Global Positioning Systems in Team Sport: A Brief Review.

    Science.gov (United States)

    Scott, Macfarlane T U; Scott, Tannath J; Kelly, Vincent G

    2016-05-01

    The use of global positioning systems (GPS) has increased dramatically over the last decade. Using signals from orbiting satellites, the GPS receiver calculates the exact position of the device and the speed at which the device is moving. Within team sports GPS devices are used to quantify the external load experienced by an athlete, allowing coaches to better manage trainings loads and potentially identify athletes who are overreaching or overtraining. This review aims to collate all studies that have tested either (or both) the validity or reliability of GPS devices in a team sport setting, with a particular focus on (a) measurements of distance, speed, velocities, and accelerations across all sampling rates and (b) accelerometers, player/body load and impacts in accelerometer-integrated GPS devices. A comprehensive search of the online libraries identified 22 articles that fit search criteria. The literature suggests that all GPS units, regardless of sampling rate, are capable of tracking athlete's distance during team sport movements with adequate intraunit reliability. One Hertz and 5Hz GPS units have limitations in their reporting of distance during high-intensity running, velocity measures, and short linear running (particularly those involving changes of direction), although these limitations seem to be overcome during measures recorded during team sport movements. Ten Hertz GPS devices seem the most valid and reliable to date across linear and team sport simulated running, overcoming many limitations of earlier models, whereas the increase to 15Hz GPS devices have had no additional benefit.

  2. A scalable global positioning system-free localization scheme for underwater wireless sensor networks

    KAUST Repository

    Mohammed, A.M.

    2013-05-07

    Seaweb is an acoustic communication technology that enables communication between sensor nodes. Seaweb technology utilizes the commercially available telesonar modems that has developed link and network layer firmware to provide a robust undersea communication capability. Seaweb interconnects the underwater nodes through digital signal processing-based modem by using acoustic links between the neighboring sensors. In this paper, we design and investigate a global positioning system-free passive localization protocol by integrating the innovations of levelling and localization with the Seaweb technology. This protocol uses the range data and planar trigonometry principles to estimate the positions of the underwater sensor nodes. Moreover, for precise localization, we consider more realistic conditions namely, (a) small displacement of sensor nodes due to watch circles and (b) deployment of sensor nodes over non-uniform water surface. Once the nodes are localized, we divide the whole network field into circular levels and sectors to minimize the traffic complexity and thereby increases the lifetime of the sensor nodes in the network field. We then form the mesh network inside each of the sectors that increases the reliability. The algorithm is designed in such a way that it overcomes the ambiguous nodes errata and reflected paths and therefore makes the algorithm more robust. The synthetic network geometries are so designed which can evaluate the algorithm in the presence of perfect or imperfect ranges or in case of incomplete data. A comparative study is made with the existing algorithms which proves the efficiency of our newly proposed algorithm. 2013 Mohammed et al.

  3. Global positioning system and associated technologies in animal behaviour and ecological research

    Science.gov (United States)

    Tomkiewicz, Stanley M.; Fuller, Mark R.; Kie, John G.; Bates, Kirk K.

    2010-01-01

    Biologists can equip animals with global positioning system (GPS) technology to obtain accurate (less than or equal to 30 m) locations that can be combined with sensor data to study animal behaviour and ecology. We provide the background of GPS techniques that have been used to gather data for wildlife studies. We review how GPS has been integrated into functional systems with data storage, data transfer, power supplies, packaging and sensor technologies to collect temperature, activity, proximity and mortality data from terrestrial species and birds. GPS 'rapid fixing' technologies combined with sensors provide location, dive frequency and duration profiles, and underwater acoustic information for the study of marine species. We examine how these rapid fixing technologies may be applied to terrestrial and avian applications. We discuss positional data quality and the capability for high-frequency sampling associated with GPS locations. We present alternatives for storing and retrieving data by using dataloggers (biologging), radio-frequency download systems (e.g. very high frequency, spread spectrum), integration of GPS with other satellite systems (e.g. Argos, Globalstar) and potential new data recovery technologies (e.g. network nodes). GPS is one component among many rapidly evolving technologies. Therefore, we recommend that users and suppliers interact to ensure the availability of appropriate equipment to meet animal research objectives.

  4. Determination of External Forces in Alpine Skiing Using a Differential Global Navigation Satellite System

    Directory of Open Access Journals (Sweden)

    Erich Müller

    2013-08-01

    Full Text Available In alpine ski racing the relationships between skier kinetics and kinematics and their effect on performance and injury-related aspects are not well understood. There is currently no validated system to determine all external forces simultaneously acting on skiers, particularly under race conditions and throughout entire races. To address the problem, this study proposes and assesses a method for determining skier kinetics with a single lightweight differential global navigation satellite system (dGNSS. The dGNSS kinetic method was compared to a reference system for six skiers and two turns each. The pattern differences obtained between the measurement systems (offset ± SD were −26 ± 152 N for the ground reaction force, 1 ± 96 N for ski friction and −6 ± 6 N for the air drag force. The differences between turn means were small. The error pattern within the dGNSS kinetic method was highly repeatable and precision was therefore good (SD within system: 63 N ground reaction force, 42 N friction force and 7 N air drag force allowing instantaneous relative comparisons and identification of discriminative meaningful changes. The method is therefore highly valid in assessing relative differences between skiers in the same turn, as well as turn means between different turns. The system is suitable to measure large capture volumes under race conditions.

  5. Global dynamics for switching systems and their extensions by linear differential equations

    Science.gov (United States)

    Huttinga, Zane; Cummins, Bree; Gedeon, Tomáš; Mischaikow, Konstantin

    2018-03-01

    Switching systems use piecewise constant nonlinearities to model gene regulatory networks. This choice provides advantages in the analysis of behavior and allows the global description of dynamics in terms of Morse graphs associated to nodes of a parameter graph. The parameter graph captures spatial characteristics of a decomposition of parameter space into domains with identical Morse graphs. However, there are many cellular processes that do not exhibit threshold-like behavior and thus are not well described by a switching system. We consider a class of extensions of switching systems formed by a mixture of switching interactions and chains of variables governed by linear differential equations. We show that the parameter graphs associated to the switching system and any of its extensions are identical. For each parameter graph node, there is an order-preserving map from the Morse graph of the switching system to the Morse graph of any of its extensions. We provide counterexamples that show why possible stronger relationships between the Morse graphs are not valid.

  6. Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Pei; Li, Li; Qi, Hui [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Zhou, Han-xin [Department of General Surgery, First Hospital (Shenzhen Second People' s Hospital) of Shenzhen University, 518020 Shenzhen (China); Deng, Chun-yan [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Li, Fu-rong, E-mail: frli62@yahoo.com [The Clinical Medical Research Center, The Second Clinical Medical College (Shenzhen People' s Hospital), Jinan University, 518020 Shenzhen (China); Shenzhen Institution of Gerontology, 518020 Shenzhen (China)

    2012-02-10

    Highlights: Black-Right-Pointing-Pointer The NPPCs from mouse pancreas were isolated. Black-Right-Pointing-Pointer Tet-on system for SV40 large in NPPCs was used to get RINPPCs. Black-Right-Pointing-Pointer The RINPPCs can undergo at least 80 population doublings without senescence. Black-Right-Pointing-Pointer The RINPPCs can be induced to differentiate into insulin-producing cells. Black-Right-Pointing-Pointer The combination of GLP-1 and sodium butyrate promoted the differentiation process. -- Abstract: Pancreatic stem cells or progenitor cells posses the ability of directed differentiation into pancreatic {beta} cells. However, these cells usually have limited proliferative capacity and finite lifespan in vitro. In the present study, Nestin-positive progenitor cells (NPPCs) from mouse pancreas that expressed the pancreatic stem cells or progenitor cell marker Nestin were isolated to obtain a sufficient number of differentiated pancreatic {beta} cells. Tet-on system for SV40 large T-antigen expression in NPPCs was used to achieve reversible immortalization. The reversible immortal Nestin-positive progenitor cells (RINPPCs) can undergo at least 80 population doublings without senescence in vitro while maintaining their biological and genetic characteristics. RINPPCs can be efficiently induced to differentiate into insulin-producing cells that contain a combination of glucagon-like peptide-1 (GLP-1) and sodium butyrate. The results of the present study can be used to explore transplantation therapy of type I diabetes mellitus.

  7. Analysis of the positive ionospheric response to a moderate geomagnetic storm using a global numerical model

    Directory of Open Access Journals (Sweden)

    A. A. Namgaladze

    2000-04-01

    Full Text Available Current theories of F-layer storms are discussed using numerical simulations with the Upper Atmosphere Model, a global self-consistent, time dependent numerical model of the thermosphere-ionosphere-plasmasphere-magnetosphere system including electrodynamical coupling effects. A case study of a moderate geomagnetic storm at low solar activity during the northern winter solstice exemplifies the complex storm phenomena. The study focuses on positive ionospheric storm effects in relation to thermospheric disturbances in general and thermospheric composition changes in particular. It investigates the dynamical effects of both neutral meridional winds and electric fields caused by the disturbance dynamo effect. The penetration of short-time electric fields of magnetospheric origin during storm intensification phases is shown for the first time in this model study. Comparisons of the calculated thermospheric composition changes with satellite observations of AE-C and ESRO-4 during storm time show a good agreement. The empirical MSISE90 model, however, is less consistent with the simulations. It does not show the equatorward propagation of the disturbances and predicts that they have a gentler latitudinal gradient. Both theoretical and experimental data reveal that although the ratio of [O]/[N2] at high latitudes decreases significantly during the magnetic storm compared with the quiet time level, at mid to low latitudes it does not increase (at fixed altitudes above the quiet reference level. Meanwhile, the ionospheric storm is positive there. We conclude that the positive phase of the ionospheric storm is mainly due to uplifting of ionospheric F2-region plasma at mid latitudes and its equatorward movement at low latitudes along geomagnetic field lines caused by large-scale neutral wind circulation and the passage of travelling atmospheric disturbances (TADs. The calculated zonal electric field disturbances also help to create the positive ionospheric

  8. Analysis of the positive ionospheric response to a moderate geomagnetic storm using a global numerical model

    Directory of Open Access Journals (Sweden)

    A. A. Namgaladze

    Full Text Available Current theories of F-layer storms are discussed using numerical simulations with the Upper Atmosphere Model, a global self-consistent, time dependent numerical model of the thermosphere-ionosphere-plasmasphere-magnetosphere system including electrodynamical coupling effects. A case study of a moderate geomagnetic storm at low solar activity during the northern winter solstice exemplifies the complex storm phenomena. The study focuses on positive ionospheric storm effects in relation to thermospheric disturbances in general and thermospheric composition changes in particular. It investigates the dynamical effects of both neutral meridional winds and electric fields caused by the disturbance dynamo effect. The penetration of short-time electric fields of magnetospheric origin during storm intensification phases is shown for the first time in this model study. Comparisons of the calculated thermospheric composition changes with satellite observations of AE-C and ESRO-4 during storm time show a good agreement. The empirical MSISE90 model, however, is less consistent with the simulations. It does not show the equatorward propagation of the disturbances and predicts that they have a gentler latitudinal gradient. Both theoretical and experimental data reveal that although the ratio of [O]/[N2] at high latitudes decreases significantly during the magnetic storm compared with the quiet time level, at mid to low latitudes it does not increase (at fixed altitudes above the quiet reference level. Meanwhile, the ionospheric storm is positive there. We conclude that the positive phase of the ionospheric storm is mainly due to uplifting of ionospheric F2-region plasma at mid latitudes and its equatorward movement at low latitudes along geomagnetic field lines caused by large-scale neutral wind circulation and the passage of travelling atmospheric disturbances (TADs. The calculated zonal electric field disturbances also help

  9. "His" and "her" marriage? The role of positive and negative marital characteristics in global marital satisfaction among older adults.

    Science.gov (United States)

    Boerner, Kathrin; Jopp, Daniela S; Carr, Deborah; Sosinsky, Laura; Kim, Se-Kang

    2014-07-01

    We explore gender differences in older adults' appraisals of positive and negative aspects of their marriages, examine how these appraisals relate to global marital satisfaction, and identify distinctive marital profiles associated with global satisfaction in men and women. Data are from the Changing Lives of Older Couples Study (n = 1,110). We used a variant of principal components analysis to generate marital quality profiles, based on one's endorsement of positive and negative marital characteristics. OLS regression was used to detect associations between marital profiles and global marital satisfaction. Men offered more positive marital assessments than women, particularly on items reflecting positive treatment by one's wife. Three marital quality profiles emerged: Positive, Positive-Negative, and Negative. Although marital satisfaction was best explained by positive appraisals in both genders, they were less important for men than for women. The negative profile showed a tendency for a stronger prediction in men. Prior studies show small differences in men's and women's global marital satisfaction. Our work provides evidence that the presence and magnitude of such gender differences may vary based on the specific marital component considered. We discuss ways that gender shapes marital interactions, expectations, and perceptions, and the implications of our results for the well-being of married older adults. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Differentiating Three Conceptualisations of the Relationship between Positive Development and Psychopathology during the Transition to Adulthood

    Science.gov (United States)

    O'Connor, Meredith; Sanson, Ann; Hawkins, Mary T.; Toumbourou, John W.; Letcher, Primrose; Frydenberg, Erica

    2011-01-01

    The transition to adulthood is characterised by both great potential for positive change and a relatively high incidence of problem outcomes. A multidimensional model of positive development during the transition to adulthood (at 19-20 years) has recently been proposed. However, an unresolved question regarding the nature of positive development…

  11. Detecting grizzly bear use of ungulate carcasses using global positioning system telemetry and activity data

    Science.gov (United States)

    Ebinger, Michael R.; Haroldson, Mark A.; van Manen, Frank T.; Costello, Cecily M.; Bjornlie, Daniel D.; Thompson, Daniel J.; Gunther, Kerry A.; Fortin, Jennifer K.; Teisberg, Justin E.; Pils, Shannon R; White, P J; Cain, Steven L.; Cross, Paul C.

    2016-01-01

    Global positioning system (GPS) wildlife collars have revolutionized wildlife research. Studies of predation by free-ranging carnivores have particularly benefited from the application of location clustering algorithms to determine when and where predation events occur. These studies have changed our understanding of large carnivore behavior, but the gains have concentrated on obligate carnivores. Facultative carnivores, such as grizzly/brown bears (Ursus arctos), exhibit a variety of behaviors that can lead to the formation of GPS clusters. We combined clustering techniques with field site investigations of grizzly bear GPS locations (n = 732 site investigations; 2004–2011) to produce 174 GPS clusters where documented behavior was partitioned into five classes (large-biomass carcass, small-biomass carcass, old carcass, non-carcass activity, and resting). We used multinomial logistic regression to predict the probability of clusters belonging to each class. Two cross-validation methods—leaving out individual clusters, or leaving out individual bears—showed that correct prediction of bear visitation to large-biomass carcasses was 78–88%, whereas the false-positive rate was 18–24%. As a case study, we applied our predictive model to a GPS data set of 266 bear-years in the Greater Yellowstone Ecosystem (2002–2011) and examined trends in carcass visitation during fall hyperphagia (September–October). We identified 1997 spatial GPS clusters, of which 347 were predicted to be large-biomass carcasses. We used the clustered data to develop a carcass visitation index, which varied annually, but more than doubled during the study period. Our study demonstrates the effectiveness and utility of identifying GPS clusters associated with carcass visitation by a facultative carnivore.

  12. An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons

    DEFF Research Database (Denmark)

    Friis-Møller, Nina; Nielsen, Lene Ryom; Smith, Colette

    2016-01-01

    ,663 HIV-positive persons from 20 countries in Europe and Australia, who were free of CVD at entry into the Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study. Cox regression models (full and reduced) were developed that predict the risk of a global CVD endpoint. The predictive performance...... of the D:A:D models were compared with a recent CVD prediction model from the Framingham study, which was assessed recalibrated to the D:A:D dataset. A total of 1010 CVD events occurred during 186,364.5 person-years. The full D:A:D CVD prediction model included age, gender, systolic blood pressure, smoking...... significantly predicted risk more accurately than the recalibrated Framingham model (Harrell's c-statistic of 0.791, 0.783 and 0.766 for the D:A:D full, D:A:D reduced, and Framingham models respectively; p models also more accurately predicted five-year CVD-risk for key prognostic subgroups...

  13. Implementasi Sistem Informasi Geografis Daerah Pariwisata Kabupaten Temanggung Berbasis Android dengan Global Positioning System (GPS

    Directory of Open Access Journals (Sweden)

    Kartika Imam Santoso

    2016-02-01

    Full Text Available Pariwisata merupakan aspek yang berharga bagi suatu daerah, dan semakin banyak pengunjung maka dapat memajukan kesejahteraan masyarakat di sekitar obyek pariwisata. Kabupaten Temanggung memiliki banyak obyek pariwisata, penggunaan teknologi informasi seperti menggunakan aplikasi smartphone berbasis Android dapat digunakan untuk membantu wisatawan untuk mengenal daerah pariwisata dan mengetahui rute menuju ke obyek pariwisata yang diinginkan. Implementasi Sistem Informasi Geografis (SIG di daerah wisata Temanggung bertujuan untuk membangun aplikasi Wisata Temanggung berbasis Android dan menerapkan layanan Google Maps Application Programming Interface (API untuk memudahkan wisatawan dalam memperoleh informasi pemetaan lokasi objek wisata, rute dan fasilitas pendukung wisata yang ada di Kabupaten Temanggung. Metode yang digunakan adalah model proses air terjun (waterfall. Implementasi Aplikasi Wisata Temanggung menggunakan pemrograman Javascript dengan Eclipse Luna, basis data SQLite, serta peta yang bersumber dari Google Maps API. Hasilnya berupa aplikasi Wisata Temanggung berbasis Android yang membantu memudahkan wisatawan dalam memperoleh informasi tentang obyek wisata alam, buatan, budaya, kuliner, hotel dan rute dari lokasi sekarang ke lokasi obyek wisata yang diinginkan di Kabupaten Temanggung dengan bantuan Global Positioning System (GPS.  

  14. Global Positioning System Energetic Particle Data: The Next Space Weather Data Revolution

    Science.gov (United States)

    Knipp, Delores J.; Giles, Barbara L.

    2016-01-01

    The Global Positioning System (GPS) has revolutionized the process of getting from point A to point Band so much more. A large fraction of the worlds population relies on GPS (and its counterparts from other nations) for precision timing, location, and navigation. Most GPS users are unaware that the spacecraft providing the signals they rely on are operating in a very harsh space environment the radiation belts where energetic particles trapped in Earths magnetic field dash about at nearly the speed of light. These subatomic particles relentlessly pummel GPS satellites. So by design, every GPS satellite and its sensors are radiation hardened. Each spacecraft carries particle detectors that provide health and status data to system operators. Although these data reveal much about the state of the space radiation environment, heretofore they have been available only to system operators and supporting scientists. Research scientists have long sought a policy shift to allow more general access. With the release of the National Space Weather Strategy and Action Plan organized by the White House Office of Science Technology Policy (OSTP) a sample of these data have been made available to space weather researchers. Los Alamos National Laboratory (LANL) and the National Center for Environmental Information released a months worth of GPS energetic particle data from an interval of heightened space weather activity in early 2014 with the hope of stimulating integration of these data sets into the research arena. Even before the public data release GPS support scientists from LANL showed the extraordinary promise of these data.

  15. Global Positioning System Navigation Above 76,000 km for NASA's Magnetospheric Multiscale Mission

    Science.gov (United States)

    Winternitz, Luke B.; Bamford, William A.; Price, Samuel R.; Carpenter, J. Russell; Long, Anne C.; Farahmand, Mitra

    2016-01-01

    NASA's Magnetospheric Multiscale (MMS) mission, launched in March of 2015, consists of a controlled formation of four spin-stabilized spacecraft in similar highly elliptic orbits reaching apogee at radial distances of 12 and 25 Earth radii (RE) in the first and second phases of the mission. Navigation for MMS is achieved independently on-board each spacecraft by processing Global Positioning System (GPS) observables using NASA Goddard Space Flight Center (GSFC)'s Navigator GPS receiver and the Goddard Enhanced Onboard Navigation System (GEONS) extended Kalman filter software. To our knowledge, MMS constitutes, by far, the highest-altitude operational use of GPS to date and represents a high point of over a decade of high-altitude GPS navigation research and development at GSFC. In this paper we will briefly describe past and ongoing high-altitude GPS research efforts at NASA GSFC and elsewhere, provide details on the design of the MMS GPS navigation system, and present on-orbit performance data from the first phase. We extrapolate these results to predict performance in the second phase orbit, and conclude with a discussion of the implications of the MMS results for future high-altitude GPS navigation, which we believe to be broad and far-reaching.

  16. Methodological Considerations When Quantifying High-Intensity Efforts in Team Sport Using Global Positioning System Technology.

    Science.gov (United States)

    Varley, Matthew C; Jaspers, Arne; Helsen, Werner F; Malone, James J

    2017-09-01

    Sprints and accelerations are popular performance indicators in applied sport. The methods used to define these efforts using athlete-tracking technology could affect the number of efforts reported. This study aimed to determine the influence of different techniques and settings for detecting high-intensity efforts using global positioning system (GPS) data. Velocity and acceleration data from a professional soccer match were recorded via 10-Hz GPS. Velocity data were filtered using either a median or an exponential filter. Acceleration data were derived from velocity data over a 0.2-s time interval (with and without an exponential filter applied) and a 0.3-second time interval. High-speed-running (≥4.17 m/s 2 ), sprint (≥7.00 m/s 2 ), and acceleration (≥2.78 m/s 2 ) efforts were then identified using minimum-effort durations (0.1-0.9 s) to assess differences in the total number of efforts reported. Different velocity-filtering methods resulted in small to moderate differences (effect size [ES] 0.28-1.09) in the number of high-speed-running and sprint efforts detected when minimum duration was GPS. Changes to how high-intensity efforts are defined affect reported data. Therefore, consistency in data processing is advised.

  17. Flight Test Results from Real-Time Relative Global Positioning System Flight Experiment on STS-69

    Science.gov (United States)

    Park, Young W.; Brazzel, Jack P., Jr.; Carpenter, J. Russell; Hinkel, Heather D.; Newman, James H.

    1996-01-01

    A real-time global positioning system (GPS) Kalman filter has been developed to support automated rendezvous with the International Space Station (ISS). The filter is integrated with existing Shuttle rendezvous software running on a 486 laptop computer under Windows. In this work, we present real-time and postflight results achieved with the filter on STS-69. The experiment used GPS data from an Osborne/Jet propulsion Laboratory TurboRouge receiver carried on the Wake Shield Facility (WSF) free flyer and a Rockwell Collins 3M receiver carried on the Orbiter. Real time filter results, processed onboard the Shuttle and replayed in near-time on the ground, are based on single vehicle mode operation and on 5 to 20 minute snapshots of telemetry provided by WSF for dual-vehicle mode operation. The Orbiter and WSF state vectors calculated using our filter compare favorably with precise reference orbits determined by the University of Texas Center for Space Research. The lessons learned from this experiment will be used in conjunction with future experiments to mitigate the technology risk posed by automated rendezvous and docking to the ISS.

  18. Implementasi Sistem Informasi Geografis Daerah Pariwisata Kota Semarang Berbasis Android dengan Global Positioning System (GPS

    Directory of Open Access Journals (Sweden)

    Richard RF Siahaan

    2014-01-01

    Full Text Available Pariwisata merupakan aspek yang berharga bagi suatu daerah, dengan adanya daerah wisata maka dapat memajukan kesejahteraan masyarakat sekitar. Kota Semarang memiliki daerah pariwisata yang sangat banyak, apabila sarana dan prasarana yang ada dikembangkan lebih lanjut maka dipastikan peningkatan parwisata di Kota Semarang akan semakin bertambah. Penggunaan Teknologi Informasi dapat memajukan daerah pariwisata, sehingga daerah pariwisata dapat dikenal oleh wisatawan yang ingin berkunjung ke Semarang. Sistem Informasi Geografis yang dibangun menggunakan platform android. Pada Tugas Akhir ini menggunakan Java sebagai bahasa pemorgraman dengan eclipse sebagai perangkat lunak pengembangan. Penggunaan Google Map API sebagai fungsi utama peta dalam menjalankan aplikasi serta PHP sebagai bahasa pemorgaraman sisi server dan MySQL dalam penggunaan basis data. Hasil dari perancangan Aplikasi Sistem Infomasi Geografis Kota Semarang berbasis Android ini nantinya akan memberikan informasi dalam bentuk peta yang dapat digunakan sebagai referensi bagi wisatawan yang berkunjung. Penggunaan Global Positioning System (GPS dalam aplikasi ini menjadi hal yang sangat penting dalam menentukan keberadaan wisatawan. Selain itu terdapat rute untuk menuju objek wisata yang dipilih, dalam aplikasi ini juga tersedia fasilitas-fasilitas umum seperti ATM dan Bank, Bandara, Mesjid, Gereja, Rumah Sakit dan lainnya.

  19. Detection of traveling ionospheric disturbances induced by atmospheric gravity waves using the global positioning system

    Science.gov (United States)

    Bassiri, Sassan; Hajj, George A.

    1993-01-01

    Natural and man-made events like earthquakes and nuclear explosions launch atmospheric gravity waves (AGW) into the atmosphere. Since the particle density decreases exponentially with height, the gravity waves increase exponentially in amplitude as they propagate toward the upper atmosphere and ionosphere. As atmospheric gravity waves approach the ionospheric heights, the neutral particles carried by gravity waves collide with electrons and ions, setting these particles in motion. This motion of charged particles manifests itself by wave-like fluctuations and disturbances that are known as traveling ionospheric disturbances (TID). The perturbation in the total electron content due to TID's is derived analytically from first principles. Using the tilted dipole magnetic field approximation and a Chapman layer distribution for the electron density, the variations of the total electron content versus the line-of-sight direction are numerically analyzed. The temporal variation associated with the total electron content measurements due to AGW's can be used as a means of detecting characteristics of the gravity waves. As an example, detection of tsunami generated earthquakes from their associated atmospheric gravity waves using the Global Positioning System is simulated.

  20. Component-wise positivity of solutions to periodic boundary problem for linear functional differential system

    Czech Academy of Sciences Publication Activity Database

    Domoshnitsky, A.; Hakl, Robert; Šremr, Jiří

    2012-01-01

    Roč. 112, May 22 (2012), s. 1-23 ISSN 1025-5834 Institutional support: RVO:67985840 Keywords : periodic problem * linear functional differential system * non- negative solution Subject RIV: BA - General Mathematics Impact factor: 0.879, year: 2010 http://www.journalofinequalitiesandapplications.com/content/2012/1/112

  1. Error Analysis System for Spacecraft Navigation Using the Global Positioning System (GPS)

    Science.gov (United States)

    Truong, S. H.; Hart, R. C.; Hartman, K. R.; Tomcsik, T. L.; Searl, J. E.; Bernstein, A.

    1997-01-01

    The Flight Dynamics Division (FDD) at the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) is currently developing improved space-navigation filtering algorithms to use the Global Positioning System (GPS) for autonomous real-time onboard orbit determination. In connection with a GPS technology demonstration on the Small Satellite Technology Initiative (SSTI)/Lewis spacecraft, FDD analysts and programmers have teamed with the GSFC Guidance, Navigation, and Control Branch to develop the GPS Enhanced Orbit Determination Experiment (GEODE) system. The GEODE system consists of a Kalman filter operating as a navigation tool for estimating the position, velocity, and additional states required to accurately navigate the orbiting Lewis spacecraft by using astrodynamic modeling and GPS measurements from the receiver. A parallel effort at the FDD is the development of a GPS Error Analysis System (GEAS) that will be used to analyze and improve navigation filtering algorithms during development phases and during in-flight calibration. For GEAS, the Kalman filter theory is extended to estimate the errors in position, velocity, and other error states of interest. The estimation of errors in physical variables at regular intervals will allow the time, cause, and effect of navigation system weaknesses to be identified. In addition, by modeling a sufficient set of navigation system errors, a system failure that causes an observed error anomaly can be traced and accounted for. The GEAS software is formulated using Object Oriented Design (OOD) techniques implemented in the C++ programming language on a Sun SPARC workstation. The Phase 1 of this effort is the development of a basic system to be used to evaluate navigation algorithms implemented in the GEODE system. This paper presents the GEAS mathematical methodology, systems and operations concepts, and software design and implementation. Results from the use of the basic system to evaluate

  2. Differentiated Responses of Apple Tree Floral Phenology to Global Warming in Contrasting Climatic Regions.

    Science.gov (United States)

    Legave, Jean-Michel; Guédon, Yann; Malagi, Gustavo; El Yaacoubi, Adnane; Bonhomme, Marc

    2015-01-01

    The responses of flowering phenology to temperature increases in temperate fruit trees have rarely been investigated in contrasting climatic regions. This is an appropriate framework for highlighting varying responses to diverse warming contexts, which would potentially combine chill accumulation (CA) declines and heat accumulation (HA) increases. To examine this issue, a data set was constituted in apple tree from flowering dates collected for two phenological stages of three cultivars in seven climate-contrasting temperate regions of Western Europe and in three mild regions, one in Northern Morocco and two in Southern Brazil. Multiple change-point models were applied to flowering date series, as well as to corresponding series of mean temperature during two successive periods, respectively determining for the fulfillment of chill and heat requirements. A new overview in space and time of flowering date changes was provided in apple tree highlighting not only flowering date advances as in previous studies but also stationary flowering date series. At global scale, differentiated flowering time patterns result from varying interactions between contrasting thermal determinisms of flowering dates and contrasting warming contexts. This may explain flowering date advances in most of European regions and in Morocco vs. stationary flowering date series in the Brazilian regions. A notable exception in Europe was found in the French Mediterranean region where the flowering date series was stationary. While the flowering duration series were stationary whatever the region, the flowering durations were far longer in mild regions compared to temperate regions. Our findings suggest a new warming vulnerability in temperate Mediterranean regions, which could shift toward responding more to chill decline and consequently experience late and extended flowering under future warming scenarios.

  3. Differentiated responses of apple tree floral phenology to global warming in contrasting climatic regions

    Directory of Open Access Journals (Sweden)

    Jean-Michel eLegave

    2015-12-01

    Full Text Available The responses of flowering phenology to temperature increases in temperate fruit trees have rarely been investigated in contrasting climatic regions. This is an appropriate framework for highlighting varying responses to diverse warming contexts, which would potentially combine chill accumulation declines and heat accumulation increases. To examine this issue, a data set was constituted in apple tree from flowering dates collected for two phenological stages of three cultivars in seven climate-contrasting temperate regions of Western Europe and in three mild regions, one in Northern Morocco and two in Southern Brazil. Multiple change-point models were applied to flowering date series, as well as to corresponding series of mean temperature during two successive periods, respectively determining for the fulfillment of chill and heat requirements. A new overview in space and time of flowering date changes was provided in apple tree highlighting not only flowering date advances as in previous studies but also stationary flowering date series. At global scale, differentiated flowering time patterns result from varying interactions between contrasting thermal determinisms of flowering dates and contrasting warming contexts. This may explain flowering date advances in most of European regions and in Morocco vs. stationary flowering date series in the Brazilian regions. A notable exception in Europe was found in the French Mediterranean region where the flowering date series was stationary. While the flowering duration series were stationary whatever the region, the flowering durations were far longer in mild regions compared to temperate regions. Our findings suggest a new warming vulnerability in temperate Mediterranean regions, which could shift towards responding more to chill decline and consequently experience late and extended flowering under future warming scenarios.

  4. Criterion validity and accuracy of global positioning satellite and data logging devices for wheelchair tennis court movement

    Science.gov (United States)

    Sindall, Paul; Lenton, John P.; Whytock, Katie; Tolfrey, Keith; Oyster, Michelle L.; Cooper, Rory A.; Goosey-Tolfrey, Victoria L.

    2013-01-01

    Purpose To compare the criterion validity and accuracy of a 1 Hz non-differential global positioning system (GPS) and data logger device (DL) for the measurement of wheelchair tennis court movement variables. Methods Initial validation of the DL device was performed. GPS and DL were fitted to the wheelchair and used to record distance (m) and speed (m/second) during (a) tennis field (b) linear track, and (c) match-play test scenarios. Fifteen participants were monitored at the Wheelchair British Tennis Open. Results Data logging validation showed underestimations for distance in right (DLR) and left (DLL) logging devices at speeds >2.5 m/second. In tennis-field tests, GPS underestimated distance in five drills. DLL was lower than both (a) criterion and (b) DLR in drills moving forward. Reversing drill direction showed that DLR was lower than (a) criterion and (b) DLL. GPS values for distance and average speed for match play were significantly lower than equivalent values obtained by DL (distance: 2816 (844) vs. 3952 (1109) m, P = 0.0001; average speed: 0.7 (0.2) vs. 1.0 (0.2) m/second, P = 0.0001). Higher peak speeds were observed in DL (3.4 (0.4) vs. 3.1 (0.5) m/second, P = 0.004) during tennis match play. Conclusions Sampling frequencies of 1 Hz are too low to accurately measure distance and speed during wheelchair tennis. GPS units with a higher sampling rate should be advocated in further studies. Modifications to existing DL devices may be required to increase measurement precision. Further research into the validity of movement devices during match play will further inform the demands and movement patterns associated with wheelchair tennis. PMID:23820154

  5. Comparison of global positioning system (GPS) tracking and parent-report diaries to characterize children's time-location patterns.

    Science.gov (United States)

    Elgethun, Kai; Yost, Michael G; Fitzpatrick, Cole T E; Nyerges, Timothy L; Fenske, Richard A

    2007-03-01

    Respondent error, low resolution, and study participant burden are known limitations of diary timelines used in exposure studies such as the National Human Exposure Assessment Survey (NHEXAS). Recent advances in global positioning system (GPS) technology have produced tracking devices sufficiently portable, functional and affordable to utilize in exposure assessment science. In this study, a differentially corrected GPS (dGPS) tracking device was compared to the NHEXAS diary timeline. The study also explored how GPS can be used to evaluate and improve such diary timelines by determining which location categories and which respondents are least likely to record "correct" time-location responses. A total of 31 children ages 3-5 years old wore a dGPS device for all waking hours on a weekend day while their parents completed the NHEXAS diary timeline to document the child's time-location pattern. Parents misclassified child time-location approximately 48% of the time using the NHEXAS timeline in comparison to dGPS. Overall concordance between methods was marginal (kappa=0.33-0.35). The dGPS device found that on average, children spent 76% of the 24-h study period in the home. The diary underestimated time the child spent in the home by 17%, while overestimating time spent inside other locations, outside at home, outside in other locations, and time spent in transit. Diary data for time spent outside at home and time in transit had the lowest response concordance with dGPS. The diaries of stay-at-home mothers and mothers working unskilled labor jobs had lower concordance with dGPS than did those of the other participants. The ability of dGPS tracking to collect continuous rather than categorical (ordinal) data was also demonstrated. It is concluded that automated GPS tracking measurements can improve the quality and collection efficiency of time-location data in exposure assessment studies, albeit for small cohorts.

  6. Allusive thinking (remote associations) and auditory top-down inhibition skills differentially predict creativity and positive schizotypy.

    Science.gov (United States)

    Rominger, Christian; Fink, Andreas; Weiss, Elisabeth M; Bosch, Jannis; Papousek, Ilona

    2017-03-01

    Positive schizotypy and creativity seem to be linked. However, the question still remains why they are related, and what may make the difference? As creative ideation is hypothesised as a dual process (association and inhibition), the propensity for remote associations might be a shared mechanism. However, positive schizotypy and creative thinking might be differentially linked to inhibition. Therefore, this study investigated a potentially overlapping feature of positive schizotypy and creativity (remote associations) as well as a potential dissociative factor (auditory inhibition). From a large screening sample, 46 participants covering a broad range of positive schizotypy were selected. Association proneness was assessed via two association tasks, auditory inhibition skill with the forced-left condition of the Dichotic Listening Test, and creative thinking by means of two creative ideation tests. Positive schizotypy and creative thinking were positively associated. Both traits were linked to lower rates of common associations. However, creative thinking was associated with higher and positive schizotypy with lower inhibitory control in the auditory domain. While creativity and positive schizotypy shared some variance (related to remote associations), profound inhibition skills may be vital for creative performance and may coincide with lower levels of positive schizotypy.

  7. The Creation of Differential Correction Systems and the Systems of Global Navigation Satellite System Monitoring

    National Research Council Canada - National Science Library

    Polishchuk, G. M; Kozlov, V. I; Urlichich, Y. M; Dvorkin, V. V; Gvozdev, V. V

    2002-01-01

    ... for the Russian Federation and a system of global navigation satellite system monitoring. These projects are some of the basic ones in the Federal program "Global Navigation System," aimed at maintenance and development of the GLONASS system...

  8. Rapid method for the differentiation of gram-positive and gram-negative bacteria on membrane filters.

    OpenAIRE

    Romero, S; Schell, R F; Pennell, D R

    1988-01-01

    Microfiltration has become a popular procedure for the concentration and enumeration of bacteria. We developed a rapid and sensitive method for the differentiation of gram-positive and gram-negative bacteria, utilizing a polycarbonate membrane filter, crystal violet, iodine, 95% ethanol, and 6% carbol fuchsin, that can be completed in 60 to 90 s. Gram reactions of 49 species belonging to 30 genera of bacteria were correctly determined by the filter-Gram stain. The sensitivities of the filter-...

  9. Global expression differences and tissue specific expression differences in rice evolution result in two contrasting types of differentially expressed genes

    KAUST Repository

    Horiuchi, Youko

    2015-12-23

    Background Since the development of transcriptome analysis systems, many expression evolution studies characterized evolutionary forces acting on gene expression, without explicit discrimination between global expression differences and tissue specific expression differences. However, different types of gene expression alteration should have different effects on an organism, the evolutionary forces that act on them might be different, and different types of genes might show different types of differential expression between species. To confirm this, we studied differentially expressed (DE) genes among closely related groups that have extensive gene expression atlases, and clarified characteristics of different types of DE genes including the identification of regulating loci for differential expression using expression quantitative loci (eQTL) analysis data. Results We detected differentially expressed (DE) genes between rice subspecies in five homologous tissues that were verified using japonica and indica transcriptome atlases in public databases. Using the transcriptome atlases, we classified DE genes into two types, global DE genes and changed-tissues DE genes. Global type DE genes were not expressed in any tissues in the atlas of one subspecies, however changed-tissues type DE genes were expressed in both subspecies with different tissue specificity. For the five tissues in the two japonica-indica combinations, 4.6 ± 0.8 and 5.9 ± 1.5 % of highly expressed genes were global and changed-tissues DE genes, respectively. Changed-tissues DE genes varied in number between tissues, increasing linearly with the abundance of tissue specifically expressed genes in the tissue. Molecular evolution of global DE genes was rapid, unlike that of changed-tissues DE genes. Based on gene ontology, global and changed-tissues DE genes were different, having no common GO terms. Expression differences of most global DE genes were regulated by cis-eQTLs. Expression

  10. The existence and global exponential stability of a periodic solution of a class of delay differential equations

    International Nuclear Information System (INIS)

    Tang, X H; Zou, Xingfu

    2009-01-01

    By employing Schauder's fixed point theorem and a non-Liapunov method (matrix theory, inequality analysis), we obtain some new criteria that ensure existence and global exponential stability of a periodic solution to a class of functional differential equations. Applying these criteria to a cellular neural network with time delays (delayed cellular neural network, DCNN) under a periodic environment leads to some new results that improve and generalize many existing ones we know on this topic. These results are of great significance in designs and applications of globally stable periodic DCNNs

  11. Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells.

    Science.gov (United States)

    Morizane, Ryuji; Monkawa, Toshiaki; Fujii, Shizuka; Yamaguchi, Shintaro; Homma, Koichiro; Matsuzaki, Yumi; Okano, Hideyuki; Itoh, Hiroshi

    2014-01-01

    Embryonic stem cells and induced pluripotent stem cells have the ability to differentiate into various organs and tissues, and are regarded as new tools for the elucidation of disease mechanisms as well as sources for regenerative therapies. However, a method of inducing organ-specific cells from pluripotent stem cells is urgently needed. Although many scientists have been developing methods to induce various organ-specific cells from pluripotent stem cells, renal lineage cells have yet to be induced in vitro because of the complexity of kidney structures and the diversity of kidney-component cells. Here, we describe a method of inducing renal tubular cells from mouse embryonic stem cells via the cell purification of kidney specific protein (KSP)-positive cells using an anti-KSP antibody. The global gene expression profiles of KSP-positive cells derived from ES cells exhibited characteristics similar to those of cells in the developing kidney, and KSP-positive cells had the capacity to form tubular structures resembling renal tubular cells when grown in a 3D culture in Matrigel. Moreover, our results indicated that KSP-positive cells acquired the characteristics of each segment of renal tubular cells through tubular formation when stimulated with Wnt4. This method is an important step toward kidney disease research using pluripotent stem cells, and the development of kidney regeneration therapies.

  12. 'Feeling good' unpacked : Developing design tools to facilitate a differentiated understanding of positive emotions

    NARCIS (Netherlands)

    Yoon, J.; Pohlmeyer, A.E.; Desmet, P.M.A.; Desmet, P.M.A.; Fokkinga, S.F.; Ludden, G.D.S.; Cila, N.; Van Zuthem, H.

    2016-01-01

    The range of positive emotions experienced in human-product interactions is diverse, and understanding the differences and similarities between these positive emotions can support emotion-driven design. Yet, there is little knowledge about what kind of tool would be effective to leverage

  13. Harmonic analysis and global solvability of a differential operator invariant on motion groups and semi-simple Lie groups

    International Nuclear Information System (INIS)

    El-Hussein, K.

    1991-08-01

    Let V be a real finite dimensional vector space and let K be a connected compact Lie group, which acts on V by means of a continuous linear representation ρ. Let G=V x p K be the motion group which is the semi-direct product of V by K and let P be an invariant differential operator on G. In this paper we give a necessary and sufficient condition for the global solvability of P on G. Now let G be a connected semi-simple Lie group with finite centre and let P be an invariant differential operator on G. We give also a necessary and sufficient condition for the global solvability of P on G. (author). 8 refs

  14. Global positioning systems (GPS) and microtechnology sensors in team sports: a systematic review.

    Science.gov (United States)

    Cummins, Cloe; Orr, Rhonda; O'Connor, Helen; West, Cameron

    2013-10-01

    Use of Global positioning system (GPS) technology in team sport permits measurement of player position, velocity, and movement patterns. GPS provides scope for better understanding of the specific and positional physiological demands of team sport and can be used to design training programs that adequately prepare athletes for competition with the aim of optimizing on-field performance. The objective of this study was to conduct a systematic review of the depth and scope of reported GPS and microtechnology measures used within individual sports in order to present the contemporary and emerging themes of GPS application within team sports. A systematic review of the application of GPS technology in team sports was conducted. We systematically searched electronic databases from earliest record to June 2012. Permutations of key words included GPS; male and female; age 12-50 years; able-bodied; and recreational to elite competitive team sports. The 35 manuscripts meeting the eligibility criteria included 1,276 participants (age 11.2-31.5 years; 95 % males; 53.8 % elite adult athletes). The majority of manuscripts reported on GPS use in various football codes: Australian football league (AFL; n = 8), soccer (n = 7), rugby union (n = 6), and rugby league (n = 6), with limited representation in other team sports: cricket (n = 3), hockey (n = 3), lacrosse (n = 1), and netball (n = 1). Of the included manuscripts, 34 (97 %) detailed work rate patterns such as distance, relative distance, speed, and accelerations, with only five (14.3 %) reporting on impact variables. Activity profiles characterizing positional play and competitive levels were also described. Work rate patterns were typically categorized into six speed zones, ranging from 0 to 36.0 km·h⁻¹, with descriptors ranging from walking to sprinting used to identify the type of activity mainly performed in each zone. With the exception of cricket, no standardized speed zones or definitions were observed within or

  15. Use of global positioning system for physical activity research in youth: ESPAÇOS Adolescentes, Brazil.

    Science.gov (United States)

    Alberico, Claudia Oliveira; Schipperijn, Jasper; Reis, Rodrigo S

    2017-10-01

    The built environment is an important factor associated with physical activity and sedentary behavior (SB) during adolescence. This study presents the methods for objective assessment of context-specific moderate to vigorous physical activity (MVPA) and SB, as well as describes results from the first project using such methodology in adolescents from a developing country. An initial sample of 381 adolescents was recruited from 32 census tracts in Curitiba, Brazil (2013); 80 had their homes geocoded and wore accelerometer and GPS devices for seven days. Four domains were defined as important contexts: home, school, transport and leisure. The majority of participants (n=80) were boys (46; 57.5%), with a normal BMI (52; 65.0%) and a mean age (SD) of 14.5 (5.5) years. Adolescents spent most of their time at home, engaging in SB. Overall, the largest proportion of MVPA was while in transport (17.1% of time spent in this context) and SB while in leisure (188.6min per day). Participants engaged in MVPA for a median of 28.7 (IQR 18.2-43.2) and 17.9 (IQR 9.2-32.1) minutes during week and weekend days, respectively. Participants spent most of their day in the leisure and home domains. The use of Geographic Information System (GIS), Global Positioning System (GPS) and accelerometer data allowed objective identification of the amount of time spent in MVPA and SB in four different domains. Though the combination of objective measures is still an emerging methodology, this is a promising and feasible approach to understanding interactions between people and their environments in developing countries. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Localization of Physical Activity in Primary School Children Using Accelerometry and Global Positioning System.

    Directory of Open Access Journals (Sweden)

    Rahel Bürgi

    Full Text Available Ecological approaches have highlighted the importance of the built environment as a factor affecting physical activity. However, knowledge on children's activity patterns is still incomplete. Particularly, data on the spatial context of physical activity is limited, which limits the potential to design location-based interventions effectively. Using global positioning system (GPS and accelerometry, this study aimed to identify locations where children engage in moderate-vigorous physical activity (MVPA.Participants included 119 children (11-14 years, 57% girls from public schools in Winterthur, Switzerland. During a regular school week between February and April 2013, children wore an accelerometer and GPS sensor for seven consecutive days. Time-matched accelerometer and GPS data was mapped with a geographic information system and each data point was assigned to one of seven defined activity settings. Both the absolute amount of MVPA and proportion of time in MVPA were calculated for every setting. Multilevel analyses accounting for the hierarchical structure of the data were conducted to investigate any gender differences.Children achieved most MVPA on streets (34.5% and on school grounds (33.4%. The proportion children spent in MVPA was highest in recreational facilities (19.4%, at other schools (19.2% and on streets (18.6%. Boys accumulated significantly more MVPA overall and on other school grounds (p < 0.05 and showed a significantly higher proportion of time in MVPA at own school and outside of Winterthur (p < 0.05.The results indicate the importance of streets and school grounds as activity-promoting environments. The high use of streets may be an indicator for active transportation, which appears to contribute to an active lifestyle in both genders. In contrast, the school setting is more likely to encourage physical activity in boys. Recreational facilities seem to be conducive for MVPA among both genders, although infrequently visited

  17. Environmental supportiveness for physical activity in English schoolchildren: a study using Global Positioning Systems

    Directory of Open Access Journals (Sweden)

    Griffin Simon J

    2009-07-01

    Full Text Available Abstract Background There is increasing evidence that the environment plays a role in influencing physical activity in children and adults. As children have less autonomy in their behavioural choices, neighbourhood environment supportiveness may be an important determinant of their ability to be active. Yet we know rather little about the types of environment that children use for bouts of physical activity. This study uses accelerometery and global positioning system technologies to identify the charactieristics of environments being used for bouts of continuous moderate to vigorous physical activity (MVPA in a sample of English schoolchildren. Methods The study used a convenience sample of 100 children from SPEEDY (Sport, Physical activity and Eating behaviour: Environmental Determinants in Young people, a cohort of 2064 9–10 year-olds from Norfolk, England, recruited in 2007. Children wore an ActiGraph GT1M accelerometer and a Garmin Forerunner 205 GPS unit over four consecutive days. Accelerometery data points were matched to GPS locations and bouts (5 minutes or more of MVPA were identified. Bout locations were overlaid with a detailed landcover dataset developed in a GIS to identify the types of environment supporting MVPA. Findings are presented using descriptive statistics. Results Boys were also more active than girls, spending an average of 20 (SD 23 versus 11 (SD 15 minutes per day in MVPA bouts. Children who spent more time outside the home were more active (p = 0.002, especially girls and children living in rural locations (both p Conclusion The study has developed a new methodology for the identification of environments in which bouts of continuous physical activity are undertaken. The results highlight the importance of the provision of urban gardens and greenspaces, and the maintenance of safe street environments as places for children to be active.

  18. Test-retest reliability of daily life gait speed as measured by smartphone global positioning system.

    Science.gov (United States)

    Obuchi, Shuichi P; Tsuchiya, Shuichi; Kawai, Hisashi

    2018-01-30

    Gait speed is useful in predicting adverse health outcomes among older adults. In previous studies, gait speed has typically been measured when subjects walk in laboratory settings, where they are able to intentionally change their gait speed. Thus, it is unclear whether the gait speed captured in a laboratory setting is representative of the subjects' actual walking pace in daily life. This study proposes using the more accurate "daily life gait speed" (DGS), measured as the subject's average gait speed over a week-long period using the global positioning system (GPS) in their smartphone. We examined the test-retest reliability of the DGS measure in the present study. Three daily life gait parameters with 186 volunteers (57 men and 129 women), aged 19 to 84 years, were measured using a smartphone application: DGS, average of daily gait cycle during a week (DCY), and average of daily cadence during a week (DCA). Test-retest reliability of the daily gait parameters between test week (T1) and retest week (T2) was assessed with the intraclass correlation coefficient, ICC (2,1), and systematic biases were observed via Bland-Altman plots. The ICCs between the daily gait parameters at T1 and T2 were 0.902 for DGS, 0.916 for DCY, and 0.917 for DCA. The Bland-Altman plots showed no significant fixed or proportional bias between the measurements at T1 and T2. These results verify that the test-retest reliability of the daily gait parameters in the present study was adequate. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Development of a wearable global positioning system for place and health research

    Directory of Open Access Journals (Sweden)

    Sawada Mike

    2008-11-01

    Full Text Available Abstract Background An increasing number of studies suggest that characteristics of context, or the attributes of the places within which we live, work and socialize, are associated with variations in health-related behaviours and outcomes. The challenge for health research is to ensure that these places are accurately represented spatially, and to identify those aspects of context that are related to variations in health and amenable to modification. This study focuses on the design of a wearable global positioning system (GPS data logger for the purpose of objectively measuring the temporal and spatial features of human activities. Person-specific GPS data provides a useful source of information to operationalize the concept of place. Results We designed and tested a lightweight, wearable GPS receiver, capable of logging location information for up to 70 hours continuously before recharging. The device is accurate to within 7 m in typical urban environments and performs well across a range of static and dynamic conditions. Discussion Rather than rely on static areal units as proxies for places, wearable GPS devices can be used to derive a more complete picture of the different places that influence an individual's wellbeing. The measures are objective and are less subject to biases associated with recall of location or misclassification of contextual attributes. This is important for two reasons. First, it brings a dynamic perspective to place and health research. The influence of place on health is dynamic in that certain places are more or less relevant to wellbeing as determined by the length of time in any location and by the frequency of activity in the location. Second, GPS data can be used to assess whether the characteristics of places at specific times are useful to explaining variations in health and wellbeing.

  20. Differentiation of toxoplasmosis and lymphoma in HIV-positive patients with gadolinium-enhanced MR imaging

    International Nuclear Information System (INIS)

    Eisenberg, A.D.; Mani, J.R.; Norman, D.

    1990-01-01

    This paper determines whether gadolinium-enhanced MR imaging can be used to differentiate toxoplasmosis and lymphoma in patients with acquired immunodeficiency syndrome. One hundred fifty-nine lesions from 71 MR examinations of eight patients with lymphoma were evaluated for size, location, enhancement characteristics, lesion multiplicity. Multiple lesions occurred in 72% of toxoplasmosis and 75% of lymphoma cases. Toxoplasmosis lesions are smaller, with lesion most commonly between 1 and 2 cm, whereas lymphoma is most often between 2 and 3 cm. Except for a propensity for lymphoma to occur in the temporal lobes, no difference in lesion location was found. Both conditions usually markedly enhance, but the pattern of enhancement differs

  1. Determination of locational error associated with global positioning system (GPS) radio collars in relation to vegetation and topography in north-central New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, K.; Biggs, J.; Fresquez, P.R.

    1997-02-01

    In 1996, a study was initiated to assess seasonal habitat use and movement patterns of Rocky Mountain elk (Cervus elaphus nelsoni) using global positioning system (GPS) radio collars. As part of this study, the authors attempted to assess the accuracies of GPS (non-differentially corrected) positions under various vegetation canopies and terrain conditions with the use of a GPS ``test`` collar. The test collar was activated every twenty minutes to obtain a position location and continuously uplinked to Argos satellites to transfer position data files. They used a Telonics, Inc. uplink receiver to intercept the transmission and view the results of the collar in real time. They placed the collar on a stand equivalent to the neck height of an adult elk and then placed the stand within three different treatment categories: (1) topographical influence (canyon and mesa tops), (2) canopy influence (open and closed canopy), and (3) vegetation type influence (ponderosa pine and pinion pine-juniper). The collar was kept at each location for one hour (usually obtaining three fixes). In addition, the authors used a hand-held GPS to obtain a position of the test collar at the same time and location.

  2. Getting from Here to There and Knowing Where: Teaching Global Positioning Systems to Students with Visual Impairments

    Science.gov (United States)

    Phillips, Craig L.

    2011-01-01

    Global Positioning Systems' (GPS) technology is available for individuals with visual impairments to use in wayfinding and address Lowenfeld's "three limitations of blindness." The considerations and methodologies for teaching GPS usage have developed over time as GPS information and devices have been integrated into orientation and mobility…

  3. Global Exponential Stability of Positive Almost Periodic Solutions for a Fishing Model with a Time-Varying Delay

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    2014-01-01

    Full Text Available This paper is concerned with a nonautonomous fishing model with a time-varying delay. Under proper conditions, we employ a novel argument to establish a criterion on the global exponential stability of positive almost periodic solutions of the model with almost periodic coefficients and delays. Moreover, an example and its numerical simulation are given to illustrate the main results.

  4. International positioning of South African electricity prices and commodity differentiated pricing

    Directory of Open Access Journals (Sweden)

    George A. Thopila

    2013-07-01

    Full Text Available The South African electricity industry has seen a dramatic increase in prices over the past 3 years. This increase has been blanketed across all sectors and is based on a number of factors such as sector, usage and, in the case of domestic pricing, suburb. The cost of electricity in South Africa, particularly to the industrial sector, has been among the lowest in the world. In this paper, we analyse the recent price increases in the South African electricity sector and discuss the price determination mechanism employed by Eskom, South Africa's electricity provider. We also analyse the revenue and sales of Eskom and review the electricity price from an international perspective. The concept of differential pricing and international benchmarking is analysed as a possibility for the South African industrial electricity industry, so that all sectors are not adversely affected by across-the-board increases. Our aim is to raise the question of whether South Africa's electricity prices are in line with international increases and to suggest the possibility of differentiated prices in the local electricity sector.

  5. Inequalities in child mortality in Mozambique: differentials by parental socio-economic position

    DEFF Research Database (Denmark)

    Macassa, Gloria; Ghilagaber, Gebrenegus; Bernhardt, Eva

    2003-01-01

    This study investigates the relation between socio-economic parental position (education and occupation) and child death in Mozambique using data from the Mozambican Demographic and Health Survey carried out between March and July 1997. The analysis included 9142 children born within 10 years...... and natural disasters) and the implementation of the Economic Structural Adjustment Programme that have also affected the health of women and their children during the years covered by this study. Other measures of socio-economic position applicable to the rural African setting should be investigated....

  6. Travel patterns during pregnancy: comparison between Global Positioning System (GPS) tracking and questionnaire data.

    Science.gov (United States)

    Wu, Jun; Jiang, Chengsheng; Jaimes, Guillermo; Bartell, Scott; Dang, Andy; Baker, Dean; Delfino, Ralph J

    2013-10-09

    Maternal exposures to traffic-related air pollution have been associated with adverse pregnancy outcomes. Exposures to traffic-related air pollutants are strongly influenced by time spent near traffic. However, little is known about women's travel activities during pregnancy and whether questionnaire-based data can provide reliable information on travel patterns during pregnancy. Examine women's in-vehicle travel behavior during pregnancy and examine the difference in travel data collected by questionnaire and global positioning system (GPS) and their potential for exposure error. We measured work-related travel patterns in 56 pregnant women using a questionnaire and one-week GPS tracking three times during pregnancy (30 weeks of gestation). We compared self-reported activities with GPS-derived trip distance and duration, and examined potentially influential factors that may contribute to differences. We also described in-vehicle travel behavior by pregnancy periods and influences of demographic and personal factors on daily travel times. Finally, we estimated personal exposure to particle-bound polycyclic aromatic hydrocarbon (PB-PAH) and examined the magnitude of exposure misclassification using self-reported vs. GPS travel data. Subjects overestimated both trip duration and trip distance compared to the GPS data. We observed moderately high correlations between self-reported and GPS-recorded travel distance (home to work trips: r = 0.88; work to home trips: r = 0.80). Better agreement was observed between the GPS and the self-reported travel time for home to work trips (r = 0.77) than work to home trips (r = 0.64). The subjects on average spent 69 and 93 minutes traveling in vehicles daily based on the GPS and self-reported data, respectively. Longer daily travel time was observed among participants in early pregnancy, and during certain pregnancy periods in women with higher education attainment, higher income, and no children. When comparing

  7. Refining Time-Activity Classification of Human Subjects Using the Global Positioning System.

    Science.gov (United States)

    Hu, Maogui; Li, Wei; Li, Lianfa; Houston, Douglas; Wu, Jun

    2016-01-01

    Detailed spatial location information is important in accurately estimating personal exposure to air pollution. Global Position System (GPS) has been widely used in tracking personal paths and activities. Previous researchers have developed time-activity classification models based on GPS data, most of them were developed for specific regions. An adaptive model for time-location classification can be widely applied to air pollution studies that use GPS to track individual level time-activity patterns. Time-activity data were collected for seven days using GPS loggers and accelerometers from thirteen adult participants from Southern California under free living conditions. We developed an automated model based on random forests to classify major time-activity patterns (i.e. indoor, outdoor-static, outdoor-walking, and in-vehicle travel). Sensitivity analysis was conducted to examine the contribution of the accelerometer data and the supplemental spatial data (i.e. roadway and tax parcel data) to the accuracy of time-activity classification. Our model was evaluated using both leave-one-fold-out and leave-one-subject-out methods. Maximum speeds in averaging time intervals of 7 and 5 minutes, and distance to primary highways with limited access were found to be the three most important variables in the classification model. Leave-one-fold-out cross-validation showed an overall accuracy of 99.71%. Sensitivities varied from 84.62% (outdoor walking) to 99.90% (indoor). Specificities varied from 96.33% (indoor) to 99.98% (outdoor static). The exclusion of accelerometer and ambient light sensor variables caused a slight loss in sensitivity for outdoor walking, but little loss in overall accuracy. However, leave-one-subject-out cross-validation showed considerable loss in sensitivity for outdoor static and outdoor walking conditions. The random forests classification model can achieve high accuracy for the four major time-activity categories. The model also performed well

  8. Automated time activity classification based on global positioning system (GPS) tracking data.

    Science.gov (United States)

    Wu, Jun; Jiang, Chengsheng; Houston, Douglas; Baker, Dean; Delfino, Ralph

    2011-11-14

    Air pollution epidemiological studies are increasingly using global positioning system (GPS) to collect time-location data because they offer continuous tracking, high temporal resolution, and minimum reporting burden for participants. However, substantial uncertainties in the processing and classifying of raw GPS data create challenges for reliably characterizing time activity patterns. We developed and evaluated models to classify people's major time activity patterns from continuous GPS tracking data. We developed and evaluated two automated models to classify major time activity patterns (i.e., indoor, outdoor static, outdoor walking, and in-vehicle travel) based on GPS time activity data collected under free living conditions for 47 participants (N = 131 person-days) from the Harbor Communities Time Location Study (HCTLS) in 2008 and supplemental GPS data collected from three UC-Irvine research staff (N = 21 person-days) in 2010. Time activity patterns used for model development were manually classified by research staff using information from participant GPS recordings, activity logs, and follow-up interviews. We evaluated two models: (a) a rule-based model that developed user-defined rules based on time, speed, and spatial location, and (b) a random forest decision tree model. Indoor, outdoor static, outdoor walking and in-vehicle travel activities accounted for 82.7%, 6.1%, 3.2% and 7.2% of manually-classified time activities in the HCTLS dataset, respectively. The rule-based model classified indoor and in-vehicle travel periods reasonably well (Indoor: sensitivity > 91%, specificity > 80%, and precision > 96%; in-vehicle travel: sensitivity > 71%, specificity > 99%, and precision > 88%), but the performance was moderate for outdoor static and outdoor walking predictions. No striking differences in performance were observed between the rule-based and the random forest models. The random forest model was fast and easy to execute, but was likely less robust

  9. Refining Time-Activity Classification of Human Subjects Using the Global Positioning System.

    Directory of Open Access Journals (Sweden)

    Maogui Hu

    Full Text Available Detailed spatial location information is important in accurately estimating personal exposure to air pollution. Global Position System (GPS has been widely used in tracking personal paths and activities. Previous researchers have developed time-activity classification models based on GPS data, most of them were developed for specific regions. An adaptive model for time-location classification can be widely applied to air pollution studies that use GPS to track individual level time-activity patterns.Time-activity data were collected for seven days using GPS loggers and accelerometers from thirteen adult participants from Southern California under free living conditions. We developed an automated model based on random forests to classify major time-activity patterns (i.e. indoor, outdoor-static, outdoor-walking, and in-vehicle travel. Sensitivity analysis was conducted to examine the contribution of the accelerometer data and the supplemental spatial data (i.e. roadway and tax parcel data to the accuracy of time-activity classification. Our model was evaluated using both leave-one-fold-out and leave-one-subject-out methods.Maximum speeds in averaging time intervals of 7 and 5 minutes, and distance to primary highways with limited access were found to be the three most important variables in the classification model. Leave-one-fold-out cross-validation showed an overall accuracy of 99.71%. Sensitivities varied from 84.62% (outdoor walking to 99.90% (indoor. Specificities varied from 96.33% (indoor to 99.98% (outdoor static. The exclusion of accelerometer and ambient light sensor variables caused a slight loss in sensitivity for outdoor walking, but little loss in overall accuracy. However, leave-one-subject-out cross-validation showed considerable loss in sensitivity for outdoor static and outdoor walking conditions.The random forests classification model can achieve high accuracy for the four major time-activity categories. The model also

  10. A Norwegian policy position in a national and global ECT context

    International Nuclear Information System (INIS)

    Akselsen, Olav

    2008-01-01

    The presentation presents views on global warming, greenhouse gases, Co2 emissions, the Norwegian climate policies and environmental preservation contributions and the future emission situation. Various management and research aspects are discussed (tk)

  11. Global Positioning: Houqua and His China Trade Partners in the Nineteenth Century

    OpenAIRE

    Wong, John

    2012-01-01

    This study unearths the lost world of early-nineteenth-century Canton. Known today as Guangzhou, this Chinese city witnessed the economic dynamism of global commerce until the demise of the Canton System in 1842. Records of its commercial vitality and global interactions faded only because we have allowed our image of old Canton to be clouded by China's weakness beginning in the mid-1800s. By reviving this story of economic vibrancy, I restore the historical contingency at the juncture at wh...

  12. Writing, Reading, and Listening Differentially Overload Working Memory Performance Across the Serial Position Curve.

    Science.gov (United States)

    Tindle, Richard; Longstaff, Mitchell G

    2015-01-01

    Previous research has assumed that writing is a cognitively complex task, but has not determined if writing overloads Working Memory more than reading and listening. To investigate this, participants completed three recall tasks. These were reading lists of words before recalling them, hearing lists of words before recalling them, and hearing lists of words and writing them as they heard them, then recalling them. The experiment involved serial recall of lists of 6 words. The hypothesis that fewer words would be recalled overall when writing was supported. Post-hoc analysis revealed the same pattern of results at individual serial positions (1 to 3). However, there was no difference between the three conditions at serial position 4, or between listening and writing at positions 5 and 6 which were both greater than recall in the reading condition. This suggests writing overloads working memory more than reading and listening, particularly in the early serial positions. The results show that writing interferes with working memory processes and so is not recommended when the goal is to immediately recall information.

  13. The differential effects of position, ad and reader characteristics on readers' processing of newspaper ads

    NARCIS (Netherlands)

    Smit, E.G.; Neijens, P.C.; Heath, R.

    2013-01-01

    Building on previous research on the processing of newspaper ads, this comprehensive field study, with 26,556 newspaper readers and 290 unique advertisements, investigated the combined effects of position in the newspaper, ad characteristics and reader characteristics. The results show a

  14. Imagined Positive Emotions and Inhibitory Control: The Differentiated Effect of Pride versus Happiness

    Science.gov (United States)

    Katzir, Maayan; Eyal, Tal; Meiran, Nachshon; Kessler, Yoav

    2010-01-01

    "Inhibitory control" is a cognitive mechanism that contributes to successful self-control (i.e., adherence to a long-term goal in the face of an interfering short-term goal). This research explored the effect of imagined positive emotional events on inhibition. The authors proposed that the influence of imagined emotions on inhibition…

  15. Inequalities in child mortality in Mozambique: differentials by parental socio-economic position

    DEFF Research Database (Denmark)

    Macassa, Gloria; Ghilagaber, Gebrenegus; Bernhardt, Eva

    2003-01-01

    This study investigates the relation between socio-economic parental position (education and occupation) and child death in Mozambique using data from the Mozambican Demographic and Health Survey carried out between March and July 1997. The analysis included 9142 children born within 10 years...

  16. An Examination of Global University Rankings as a New Mechanism Influencing Mission Differentiation: The UK Context

    Science.gov (United States)

    O'Connell, Catherine

    2015-01-01

    Since their emergence a decade ago, global university rankings have become a powerful force in higher education internationally. The majority of research studies on global rankings have examined the effects at institutional and national levels. This study offers a valuable perspective on the ways rankings (and other international benchmarks) are…

  17. Differential climate impacts for policy-relevant limits to global warming

    NARCIS (Netherlands)

    Schleussner, Carl Friedrich; Lissner, Tabea K.; Fischer, Erich M.; Wohland, Jan; Perrette, Mahé; Golly, Antonius; Rogelj, Joeri; Childers, Katelin; Schewe, Jacob; Frieler, Katja; Mengel, Matthias; Hare, William; Schaeffer, Michiel

    2016-01-01

    Robust appraisals of climate impacts at different levels of global-mean temperature increase are vital to guide assessments of dangerous anthropogenic interference with the climate system. The 2015 Paris Agreement includes a two-headed temperature goal: "holding the increase in the global average

  18. Differentiation strategies in coffee global value chains through reference to territorial origin in Latin American countries

    Directory of Open Access Journals (Sweden)

    Marescotti, Andrea

    2016-06-01

    Full Text Available For many years coffee has been regarded as a commodity. Recently, new trends both at consumption and production level created new opportunities for de-commodifying the coffee market, by a differentiation based on social, environmental and territorial resources, and consequently for strengthening local agro-food systems and improving the position of farmers in the value chain. In this perspective, territorial origin is one promising lever of differentiation, and there is a growing number of initiatives trying to develop protected Geographical Indications in coffee value chains. This work aims at identifying the different logics surrounding the construction of protected Geographical Indications (GIs in the coffee industry in Latin America, and to discuss the role of history and tradition in relation to the link to specific local resources. Our analysis highlights a variety of typologies of GI initiatives, which follow different logics and strategies, and interpret the concept of “origin” in different ways, especially when compared to the European Union one. However the role that history and traditions play in American coffee GIs is not yet relevant.Durante mucho tiempo, el café ha sido considerado como un producto commodity, de carácter indiferenciado. Recientemente, nuevas tendencias en la producción y el consumo de café han creado nuevas oportunidades para emprender estrategias de diferenciación (de-commodify en el mercado del café, basadas en los recursos locales de carácter social, medioambiental y territorial y, consecuentemente, con una finalidad de impulsar los sistemas agroalimentarios locales y de mejorar la situación de los agricultores en la cadena de valor. Desde esta perspectiva, el origen territorial se convierte en una herramienta prometedora de diferenciación del producto. Existe un número creciente de iniciativas cuyo propósito es desarrollar Indicaciones Geográficas (IGs en el ámbito de las cadenas de valor del

  19. “His” and “Her” Marriage? The Role of Positive and Negative Marital Characteristics in Global Marital Satisfaction Among Older Adults

    OpenAIRE

    Boerner, Kathrin; Jopp, Daniela S.; Carr, Deborah; Sosinsky, Laura; Kim, Se-Kang

    2014-01-01

    Objectives. We explore gender differences in older adults’ appraisals of positive and negative aspects of their marriages, examine how these appraisals relate to global marital satisfaction, and identify distinctive marital profiles associated with global satisfaction in men and women.

  20. A ppendicitis with Positive Ultrasound and its Relation to Total and Differential Leucocytic Count

    International Nuclear Information System (INIS)

    Saleh, G.M.; Sabek, E.A.S.; Elessiely, E.S.; Ibrahim, E.M.

    2016-01-01

    Background:The most common cause of acute surgical abdomen is acute appendicitis and the most commonly done emergency surgery is appendectomy. Although a battery of tests and different scoring methods are available for diagnosis of acute appendicitis, it is very difficult to prevent negative explorations for appendicectomy (15 - 30%). None of the tests has satisfactory Sensitivity and specificity that can be relied upon. Objectives: The aim of the present study was to evaluate the role of total and differential leukocyte count, and ultrasonography (USG) of abdomen in diagnosing acute appendicitis and reducing the rates of negative appendicectomies and to prevent complications like perforation, peritonitis, and the longer the delay between diagnosis and surgery, the more likely is the perforation leading to peritonitis. In addition, emphasis was given to whether combining the investigations for the same patient would improve the diagnostic accuracy. Materials and Methods : A total of 76 clinically diagnosed patients of acute appendicitis, posted for emergency appendicectomy were included in the study in General Surgery Department of EL-Salam Hospital. This study was conducted in the period October 2012 to September 2013. Preoperatively blood tests for, total leukocyte count, differential leukocyte count(DLC) and USG abdomen were done. All patients were subjected to histological examination postoperatively, which was taken as the gold standard. The three investigations results were correlated with histopathological examination reports to evaluate their role in diagnosis of acute appendicitis. Results: In the present study, the US has the highest sensitivity and specificity (90%, 80%) followed by Total leucocyte count (87.5%, 90%), white Neutrophil count (78.75%, 80%). Combining US and WBC count increases the sensitivity and specificity of the tests (96.25%, 80%). Conclusion: US contains important diagnostic information and hence should always be included in the

  1. Incentive Compatible and Globally Efficient Position Based Routing for Selfish Reverse Multicast in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Sarvesh Varatharajan

    2009-10-01

    Full Text Available We consider the problem of all-to-one selfish routing in the absence of a payment scheme in wireless sensor networks, where a natural model for cost is the power required to forward, referring to the resulting game as a Locally Minimum Cost Forwarding (LMCF. Our objective is to characterize equilibria and their global costs in terms of stretch and diameter, in particular finding incentive compatible algorithms that are also close to globally optimal. We find that although social costs for equilibria of LMCF exhibit arbitrarily bad worst-case bounds and computational infeasibility of reaching optimal equilibria, there exist greedy and local incentive compatible heuristics achieving near-optimal global costs.

  2. Dynamical Approach Study of Spurious Steady-State Numerical Solutions of Nonlinear Differential Equations. 2; Global Asymptotic Behavior of Time Discretizations; 2. Global Asymptotic Behavior of time Discretizations

    Science.gov (United States)

    Yee, H. C.; Sweby, P. K.

    1995-01-01

    The global asymptotic nonlinear behavior of 1 1 explicit and implicit time discretizations for four 2 x 2 systems of first-order autonomous nonlinear ordinary differential equations (ODES) is analyzed. The objectives are to gain a basic understanding of the difference in the dynamics of numerics between the scalars and systems of nonlinear autonomous ODEs and to set a baseline global asymptotic solution behavior of these schemes for practical computations in computational fluid dynamics. We show how 'numerical' basins of attraction can complement the bifurcation diagrams in gaining more detailed global asymptotic behavior of time discretizations for nonlinear differential equations (DEs). We show how in the presence of spurious asymptotes the basins of the true stable steady states can be segmented by the basins of the spurious stable and unstable asymptotes. One major consequence of this phenomenon which is not commonly known is that this spurious behavior can result in a dramatic distortion and, in most cases, a dramatic shrinkage and segmentation of the basin of attraction of the true solution for finite time steps. Such distortion, shrinkage and segmentation of the numerical basins of attraction will occur regardless of the stability of the spurious asymptotes, and will occur for unconditionally stable implicit linear multistep methods. In other words, for the same (common) steady-state solution the associated basin of attraction of the DE might be very different from the discretized counterparts and the numerical basin of attraction can be very different from numerical method to numerical method. The results can be used as an explanation for possible causes of error, and slow convergence and nonconvergence of steady-state numerical solutions when using the time-dependent approach for nonlinear hyperbolic or parabolic PDES.

  3. Financial Incentives Differentially Regulate Neural Processing of Positive and Negative Emotions during Value-Based Decision-Making

    Directory of Open Access Journals (Sweden)

    Anne M. Farrell

    2018-02-01

    Full Text Available Emotional and economic incentives often conflict in decision environments. To make economically desirable decisions then, deliberative neural processes must be engaged to regulate automatic emotional reactions. In this functional magnetic resonance imaging (fMRI study, we evaluated how fixed wage (FW incentives and performance-based (PB financial incentives, in which pay is proportional to outcome, differentially regulate positive and negative emotional reactions to hypothetical colleagues that conflicted with the economics of available alternatives. Neural activity from FW to PB incentive contexts decreased for positive emotional stimuli but increased for negative stimuli in middle temporal, insula, and medial prefrontal regions. In addition, PB incentives further induced greater responses to negative than positive emotional decisions in the frontal and anterior cingulate regions involved in emotion regulation. Greater response to positive than negative emotional features in these regions also correlated with lower frequencies of economically desirable choices. Our findings suggest that whereas positive emotion regulation involves a reduction of responses in valence representation regions, negative emotion regulation additionally engages brain regions for deliberative processing and signaling of incongruous events.

  4. Differentiation of penal policy in the light of positive paradigm and its confronting challenges

    Directory of Open Access Journals (Sweden)

    Bagher Shamlou

    2015-05-01

    Full Text Available Positivism is an empirical approach for understanding of human communication and phenomena, which raised firstly French famous thinker “August Comte”. Human and social Sciences were under domination of positive thought for a long time. In criminal law inter alia Italian famous thinkers sought to analyses the crime problem with a positive approach. However, some of their point of view such as born criminal thesis was not respected by penal scientist, but was affected by their idea was assumed that experiment is the only scientific criterion and basis of criminal law. They thought that value judgments and normative sentences have not scientific character. The positivist approach, developed the abstract thought of classic criminal fundamentalism which was before this, the dominate approach of penal policy towards of objectivism at etiology of crime on the basis of separation of objectivism and subjectivism. But it faced with insufficiency in both methodology and efficiency, so that somebody talked about returning punity approach of classic fundamentalism

  5. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup.

    Science.gov (United States)

    Beck, Emily A; Llopart, Ana

    2015-11-25

    Rapid evolution of centromeric satellite repeats is thought to cause compensatory amino acid evolution in interacting centromere-associated kinetochore proteins. Cid, a protein that mediates kinetochore/centromere interactions, displays particularly high amino acid turnover. Rapid evolution of both Cid and centromeric satellite repeats led us to hypothesize that the apparent compensatory evolution may extend to interacting partners in the Condensin I complex (i.e., SMC2, SMC4, Cap-H, Cap-D2, and Cap-G) and HP1s. Missense mutations in these proteins often result in improper centromere formation and aberrant chromosome segregation, thus selection for maintained function and coevolution among proteins of the complex is likely strong. Here, we report evidence of rapid evolution and recurrent positive selection in seven centromere-associated proteins in species of the Drosophila melanogaster subgroup, and further postulate that positive selection on these proteins could be a result of centromere drive and compensatory changes, with kinetochore proteins competing for optimal spindle attachment.

  6. Aggressiveness, social support and school experiences as dimensions differentiating negative and positive adaptation among adolescents

    Directory of Open Access Journals (Sweden)

    Marzanna Agnieszka Farnicka

    2017-10-01

    Full Text Available Background The study results presented below lie within a field of study which seeks to identify appropriate risk indicators for risky behaviours in the group of adolescents. The study drew on the tenets of developmental psychopathology. Adaptation assessment was performed on the basis of an objective indicator which comprised adolescents’ problems with social functioning. Participants and procedure The main determinants of the observed changes in behaviour and the development of adaptation pathways during the period of adolescence were considered to include bio-psycho-social temperamental factors (Buss & Plomin, 1984, attachment patterns (Armsden & Greenberg, 1987, trait of aggressiveness (Buss & Perry, 1992, conditions created by the environment (support of family members, peers and teachers [Malecki & Demaray, 2002] as well as previous experiences such as being a victim of violence (Osterman & Bjorqvist, 2008 or the level of school success. The final study group comprised a total of 140 positively and 140 negatively adapted teenagers (N = 280 between the ages of 12 and 19. The study was carried out in Poland. Results The study confirmed the gender effect, demonstrating a higher frequency of involvement in risky behaviours among boys. The results from searching for differences between positively and negatively adapted teens showed that in the negatively adapted group there were lower grades at school and more frequent aggressive behaviour. Conclusions The main conclusion that can be drawn from the study is that the potential prophylactic and therapeutic interventions require consideration of factors such as age, educational success, aggressiveness and social support.

  7. Invited review: A position on the Global Livestock Environmental Assessment Model (GLEAM)

    NARCIS (Netherlands)

    MacLeod, M.J.; Vellinga, T.; Opio, C.; Falcucci, A.; Tempio, G.; Henderson, B.; Makkar, H.; Mottet, A.; Robinson, T.; Steinfeld, H.; Gerber, P.J.

    2018-01-01

    The livestock sector is one of the fastest growing subsectors of the agricultural economy and, while it makes a major contribution to global food supply and economic development, it also consumes significant amounts of natural resources and alters the environment. In order to improve our

  8. Opening up to the world? Khartoum's position within a global city network

    NARCIS (Netherlands)

    Mans, U.

    2009-01-01

    This article presents three arguments for a new research perspective on global city networks analysis and introduces possible modifications to existing assessment tools in order to investigate the role of emerging market cities. The first argument highlights the need to investigate more ‘peripheral’

  9. Globalization

    Directory of Open Access Journals (Sweden)

    Tulio Rosembuj

    2006-12-01

    Full Text Available There is no singular globalization, nor is the result of an individual agent. We could start by saying that global action has different angles and subjects who perform it are different, as well as its objectives. The global is an invisible invasion of materials and immediate effects.

  10. Globalization

    OpenAIRE

    Tulio Rosembuj

    2006-01-01

    There is no singular globalization, nor is the result of an individual agent. We could start by saying that global action has different angles and subjects who perform it are different, as well as its objectives. The global is an invisible invasion of materials and immediate effects.

  11. Job stress, occupational position and gender as factors differentiating workplace bullying experience

    Directory of Open Access Journals (Sweden)

    Marcin Drabek

    2013-06-01

    Full Text Available Background: The results of our research broaden the knowledge concerning the correlates of mobbing. The study is aimed at finding out whether an employee's gender, his/her occupational position and level of occupational stress are related to bullying experience. Material and Methods: 1313 employees of a transport company participated in the study. The relationships between gender, occupational position, the level of stress and bullying were analysed. Bullying was measured by the use of the MDM Questionnaire, while work environment was assessed using the Subjective Assessment of Work Questionnaire. Results: It was found that women were generally more exposed to bullying than men (Z = –1.999; p < 0.05. Women experienced more bullying by their colleagues than men did (Z = –2.712; p < 0.01, in particular: bullying by colleagues that destroys the worker's image (Z = –2.922; p < 0.01 and bullying by colleagues that destroys social relations (Z = –3.004; p < 0.01. Individuals with managerial jobs experienced overall bullying (Z = –2.762; p < 0.01, bullying by colleagues (Z = –0.014; p < 0.05 and bullying by colleagues that destroys social relations (Z = –2.260; p < 0.05 more often than the individuals with non-management positions. The results of the study also indicated that employees with higher level of stress in comparison with less stressed co-workers reported more incidents of bullying behaviour (overall bullying – Z = –8.171; p < 0.001, bullying by colleagues – Z = –7.114; p < 0.001, bullying by supervisors – Z = –6.716; p < 0.001, all types of behaviour – p < 0.001. Conclusions: Comparing the results of our study to the previous research, it seems that the pattern of relationships between individual characteristics and bullying is rooted in the wider cultural context, the specificity of the company, its organisational culture as well as its situation. Therefore it's difficult to talk about irrefutable individual

  12. Job stress, occupational position and gender as factors differentiating workplace bullying experience.

    Science.gov (United States)

    Drabek, Marcin; Merecz, Dorota

    2013-01-01

    The results of our research broaden the knowledge concerning the correlates of mobbing. The study is aimed at finding out whether an employee's gender, his/her occupational position and level of occupational stress are related to bullying experience. 1313 employees of a transport company participated in the study. The relationships between gender, occupational position, the level of stress and bullying were analysed. Bullying was measured by the use of the MD)M Questionnaire, while work environment was assessed using the Subjective Assessment of Work Questionnaire. It was found that women were generally more exposed to bullying than men (Z = -1.999; p < 0.05). Women experienced more bullying by their colleagues than men did (Z = -2.712; p < 0.01), in particular: bullying by colleagues that destroys the worker's image (Z = -2.922; p < 0.01) and bullying by colleagues that destroys social relations (Z = -3.004; p < 0.01). Individuals with managerial jobs experienced overall bullying (Z = -2.762; p < 0.01), bullying by colleagues (Z = -0.014; p < 0.05) and bullying by colleagues that destroys social relations (Z = -2.260; p < 0.05) more often than the individuals with non-management positions. The results of the study also indicated that employees with higher level of stress in comparison with less stressed co-workers reported more incidents of bullying behaviour (overall bullying--Z = -8.171; p < 0.001, bullying by colleagues - Z = -7.114; p < 0.001, bullying by supervisors--Z = -6.716; p < 0.001, all types of behaviour - p < 0.001). Comparing the results of our study to the previous research, it seems that the pattern of relationships between individual characteristics and bullying is rooted in the wider cultural context, the specificity of the company, its organisational culture as well as its situation. Therefore it's difficult to talk about irrefutable individual correlates of bullying at work.

  13. Invited review: A position on the Global Livestock Environmental Assessment Model (GLEAM).

    Science.gov (United States)

    MacLeod, M J; Vellinga, T; Opio, C; Falcucci, A; Tempio, G; Henderson, B; Makkar, H; Mottet, A; Robinson, T; Steinfeld, H; Gerber, P J

    2018-02-01

    The livestock sector is one of the fastest growing subsectors of the agricultural economy and, while it makes a major contribution to global food supply and economic development, it also consumes significant amounts of natural resources and alters the environment. In order to improve our understanding of the global environmental impact of livestock supply chains, the Food and Agriculture Organization of the United Nations has developed the Global Livestock Environmental Assessment Model (GLEAM). The purpose of this paper is to provide a review of GLEAM. Specifically, it explains the model architecture, methods and functionality, that is the types of analysis that the model can perform. The model focuses primarily on the quantification of greenhouse gases emissions arising from the production of the 11 main livestock commodities. The model inputs and outputs are managed and produced as raster data sets, with spatial resolution of 0.05 decimal degrees. The Global Livestock Environmental Assessment Model v1.0 consists of five distinct modules: (a) the Herd Module; (b) the Manure Module; (c) the Feed Module; (d) the System Module; (e) the Allocation Module. In terms of the modelling approach, GLEAM has several advantages. For example spatial information on livestock distributions and crops yields enables rations to be derived that reflect the local availability of feed resources in developing countries. The Global Livestock Environmental Assessment Model also contains a herd model that enables livestock statistics to be disaggregated and variation in livestock performance and management to be captured. Priorities for future development of GLEAM include: improving data quality and the methods used to perform emissions calculations; extending the scope of the model to include selected additional environmental impacts and to enable predictive modelling; and improving the utility of GLEAM output.

  14. Implementation status of the global and local beam position feedback systems for the Advanced Photon Source storage ring

    International Nuclear Information System (INIS)

    Chung, Y.; Barr, D.; Decker, G.; Galayda, J.; Kirchman, J.; Lenkszus, F.; Lumpkin, A.; Votaw, A.J.

    1995-01-01

    The Advanced Photon Source (APS) is implementing an extensive beam position feedback system for both global and local stabilization of particle and photon beams based on digital signal processing. The description and operational experience of the system will be given in this paper. In particular, we will discuss the underlying fundamental principles, hardware layout, controls interface, and automatic software generation for multiple digital signal processors (DSPS) distributed in 20 VME crates around the ring. The feedback system runs at 4-kHz sampling frequency in order to achieve the correction bandwidth of approximately 100 Hz. For the maximum correction efficiency and resolution of conflicts among multiple local feedback systems due to the local bump closure error, the global and local feedback systems are combined into a single unified system. This novel approach is made possible through data sharing among the global and local systems via the fiber-optically networked reflective memories

  15. Regional differentiation and the geopolitical and transboundary position of the Presheva Valley

    Directory of Open Access Journals (Sweden)

    Ejupi Arsim

    2016-12-01

    Full Text Available The determination of the Presheva Valley as a special region highlights the need for theoretical analysis and the use of different methods and principles which enable geographical regionalization. The Presheva Valley represents a natural continuation of the Albanian ethnic territories. With a very convenient position in terms of geography and transportation, as well as its geostrategic and geopolitical basis, it has been occupied by many invaders throughout different periods of history. Under the current administrative, political and territorial division of Serbia, the municipalities of Presheva and Bujanoci belong to the Pčinja district, based in Vranje, while the municipality of Medvegja belongs to the Jablanica district, based in Leskoc. The Presheva Valley has had the status of special region in various periods, but since it shares historical, ethnic and demographic characteristics with other Albanian ethnic territories, it has frequently been separated for the purpose of the assimilation of the Albanian people.

  16. Positive Solutions for a Higher-Order Nonlinear Neutral Delay Differential Equation

    Directory of Open Access Journals (Sweden)

    Zeqing Liu

    2011-01-01

    pi,τi,βj,g∈C([to,+∞,ℝ, αj∈Cn−1([to,+∞,ℝ, f∈Cn−1([to,+∞×ℝk,ℝ, h∈C([to,+∞×ℝk,ℝ, and limt→+∞τi(t=limt→+∞αj(t=limt→+∞βj(t=+∞, i∈{1,2,…,m}, j∈{1,2,…,k}. By making use of the Leray-Schauder nonlinear alterative theorem, we establish the existence of uncountably many bounded positive solutions for the above equation. Our results improve and generalize some corresponding results in the field. Three examples are given which illustrate the advantages of the results presented in this paper.

  17. Positive circuits and d-dimensional spatial differentiation: application to the formation of sense organs in Drosophila.

    Science.gov (United States)

    Crumière, Anne; Sablik, Mathieu

    2008-01-01

    We discuss a rule proposed by the biologist Thomas according to which the possibility for a genetic network (represented by a signed directed graph called a regulatory graph) to have several stable states implies the existence of a positive circuit. This result is already known for different models, differential or discrete formalism, but always with a network of genes contained in a single cell. Thus, we can ask about the validity of this rule for a system containing several cells and with intercellular genetic interactions. In this paper, we consider the genetic interactions between several cells located on a d-dimensional lattice, i.e., each point of lattice represents a cell to which we associate the expression level of n genes contained in this cell. With this configuration, we show that the existence of a positive circuit is a necessary condition for a specific form of multistationarity, which naturally corresponds to spatial differentiation. We then illustrate this theorem through the example of the formation of sense organs in Drosophila.

  18. Breast or bottle? HIV-positive women's responses to global health policy on infant feeding in India.

    Science.gov (United States)

    Van Hollen, Cecilia

    2011-12-01

    This article describes how local responses to global health initiatives on infant feeding for HIV-positive mothers reflect and transform sociocultural values in Tamil Nadu, India. Drawing from ethnographic research conducted from 2002 to 2008, the article compares guidelines for counseling HIV-positive mothers established by UNICEF and WHO with decision-making processes and perceptions of HIV-positive mothers. In addition to the financial considerations, three factors are identified as impinging on this decision: (1) a strong sociocultural value in favor of breastfeeding linked to historical traditions and contemporary state and international development discourses, (2) constructions of class identity, (3) the influence of a rights-based discourse in HIV/AIDS advocacy. This wide range of factors points to the difficulty of implementing the international protocols. This is the first study of its kind to closely examine the complex determinants in HIV-positive women's decisions and evaluations of infant feeding methods in India.

  19. The influence of merging brands on the brand position in the global open–field vegetable seed sector / Oosthuizen, E.

    OpenAIRE

    Oosthuizen, Elzandi

    2011-01-01

    The study deals with the concept of the influence of merging brands on the brand position in the global open–field vegetable seed sector. The research, more specifically, examines the market perception and awareness of the brand regarding the company versus the competitive brands. Monsanto, as a company, deals in the market as Seminis. A tailor–made questionnaire was used as the measuring instrument. A total of 1177 respondents completed the questionnaires during interview sessions. Interv...

  20. Global analysis of differentially expressed genes and proteins in the wheat callus infected by Agrobacterium tumefaciens.

    Directory of Open Access Journals (Sweden)

    Xiaohong Zhou

    Full Text Available Agrobacterium-mediated plant transformation is an extremely complex and evolved process involving genetic determinants of both the bacteria and the host plant cells. However, the mechanism of the determinants remains obscure, especially in some cereal crops such as wheat, which is recalcitrant for Agrobacterium-mediated transformation. In this study, differentially expressed genes (DEGs and differentially expressed proteins (DEPs were analyzed in wheat callus cells co-cultured with Agrobacterium by using RNA sequencing (RNA-seq and two-dimensional electrophoresis (2-DE in conjunction with mass spectrometry (MS. A set of 4,889 DEGs and 90 DEPs were identified, respectively. Most of them are related to metabolism, chromatin assembly or disassembly and immune defense. After comparative analysis, 24 of the 90 DEPs were detected in RNA-seq and proteomics datasets simultaneously. In addition, real-time RT-PCR experiments were performed to check the differential expression of the 24 genes, and the results were consistent with the RNA-seq data. According to gene ontology (GO analysis, we found that a big part of these differentially expressed genes were related to the process of stress or immunity response. Several putative determinants and candidate effectors responsive to Agrobacterium mediated transformation of wheat cells were discussed. We speculate that some of these genes are possibly related to Agrobacterium infection. Our results will help to understand the interaction between Agrobacterium and host cells, and may facilitate developing efficient transformation strategies in cereal crops.

  1. Global Analysis of Differentially Expressed Genes and Proteins in the Wheat Callus Infected by Agrobacterium tumefaciens

    Science.gov (United States)

    Zhou, Xiaohong; Wang, Ke; Lv, Dongwen; Wu, Chengjun; Li, Jiarui; Zhao, Pei; Lin, Zhishan; Du, Lipu; Yan, Yueming; Ye, Xingguo

    2013-01-01

    Agrobacterium-mediated plant transformation is an extremely complex and evolved process involving genetic determinants of both the bacteria and the host plant cells. However, the mechanism of the determinants remains obscure, especially in some cereal crops such as wheat, which is recalcitrant for Agrobacterium-mediated transformation. In this study, differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) were analyzed in wheat callus cells co-cultured with Agrobacterium by using RNA sequencing (RNA-seq) and two-dimensional electrophoresis (2-DE) in conjunction with mass spectrometry (MS). A set of 4,889 DEGs and 90 DEPs were identified, respectively. Most of them are related to metabolism, chromatin assembly or disassembly and immune defense. After comparative analysis, 24 of the 90 DEPs were detected in RNA-seq and proteomics datasets simultaneously. In addition, real-time RT-PCR experiments were performed to check the differential expression of the 24 genes, and the results were consistent with the RNA-seq data. According to gene ontology (GO) analysis, we found that a big part of these differentially expressed genes were related to the process of stress or immunity response. Several putative determinants and candidate effectors responsive to Agrobacterium mediated transformation of wheat cells were discussed. We speculate that some of these genes are possibly related to Agrobacterium infection. Our results will help to understand the interaction between Agrobacterium and host cells, and may facilitate developing efficient transformation strategies in cereal crops. PMID:24278131

  2. Frequencies of inaudible high-frequency sounds differentially affect brain activity: positive and negative hypersonic effects.

    Science.gov (United States)

    Fukushima, Ariko; Yagi, Reiko; Kawai, Norie; Honda, Manabu; Nishina, Emi; Oohashi, Tsutomu

    2014-01-01

    The hypersonic effect is a phenomenon in which sounds containing significant quantities of non-stationary high-frequency components (HFCs) above the human audible range (max. 20 kHz) activate the midbrain and diencephalon and evoke various physiological, psychological and behavioral responses. Yet important issues remain unverified, especially the relationship existing between the frequency of HFCs and the emergence of the hypersonic effect. In this study, to investigate the relationship between the hypersonic effect and HFC frequencies, we divided an HFC (above 16 kHz) of recorded gamelan music into 12 band components and applied them to subjects along with an audible component (below 16 kHz) to observe changes in the alpha2 frequency component (10-13 Hz) of spontaneous EEGs measured from centro-parieto-occipital regions (Alpha-2 EEG), which we previously reported as an index of the hypersonic effect. Our results showed reciprocal directional changes in Alpha-2 EEGs depending on the frequency of the HFCs presented with audible low-frequency component (LFC). When an HFC above approximately 32 kHz was applied, Alpha-2 EEG increased significantly compared to when only audible sound was applied (positive hypersonic effect), while, when an HFC below approximately 32 kHz was applied, the Alpha-2 EEG decreased (negative hypersonic effect). These findings suggest that the emergence of the hypersonic effect depends on the frequencies of inaudible HFC.

  3. Frequencies of inaudible high-frequency sounds differentially affect brain activity: positive and negative hypersonic effects.

    Directory of Open Access Journals (Sweden)

    Ariko Fukushima

    Full Text Available The hypersonic effect is a phenomenon in which sounds containing significant quantities of non-stationary high-frequency components (HFCs above the human audible range (max. 20 kHz activate the midbrain and diencephalon and evoke various physiological, psychological and behavioral responses. Yet important issues remain unverified, especially the relationship existing between the frequency of HFCs and the emergence of the hypersonic effect. In this study, to investigate the relationship between the hypersonic effect and HFC frequencies, we divided an HFC (above 16 kHz of recorded gamelan music into 12 band components and applied them to subjects along with an audible component (below 16 kHz to observe changes in the alpha2 frequency component (10-13 Hz of spontaneous EEGs measured from centro-parieto-occipital regions (Alpha-2 EEG, which we previously reported as an index of the hypersonic effect. Our results showed reciprocal directional changes in Alpha-2 EEGs depending on the frequency of the HFCs presented with audible low-frequency component (LFC. When an HFC above approximately 32 kHz was applied, Alpha-2 EEG increased significantly compared to when only audible sound was applied (positive hypersonic effect, while, when an HFC below approximately 32 kHz was applied, the Alpha-2 EEG decreased (negative hypersonic effect. These findings suggest that the emergence of the hypersonic effect depends on the frequencies of inaudible HFC.

  4. Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.

    Science.gov (United States)

    Liu, Xuanyao; Yunus, Yushimah; Lu, Dongsheng; Aghakhanian, Farhang; Saw, Woei-Yuh; Deng, Lian; Ali, Mohammad; Wang, Xu; Nor, Fadzilah Mohd; Ghazali, Fadzilah; Rahman, Thuhairah Abdul; Shaari, Shahrul Azlin; Salleh, Mohd Zaki; Phipps, Maude E; Ong, Rick Twee-Hee; Xu, Shuhua; Teo, Yik-Ying; Hoh, Boon-Peng

    2015-04-01

    The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.

  5. Differential outcome of fissure-positioned tube in closed thoracostomy for primary spontaneous pneumothorax.

    Science.gov (United States)

    Kim, Yong Won; Byun, Chun Sung; Cha, Yong Sung; Kim, Oh Hyun; Lee, Kang Hyun; Park, Il Hwan

    2015-05-01

    Closed tube thoracostomy is often used to evacuate a primary spontaneous pneumothorax (PSP). Occasionally, this procedure is complicated by placement of the chest tube location in the fissural area instead of pleural space. There is a paucity of studies on outcomes according to chest tube placement. As such, we investigated outcomes of chest tube placement in fissural versus pleural area in closed thoracostomy for PSP. Patients between 14 and 65 years of age who had been treated with chest tube insertion to evacuate PSP were selected based on retrospective review of medical records. Patients selected for this study received chest tube placement at either the fissural or pleural spaces. Those with pre-existing lung disease or those transferred into our hospital after closed thoracostomy were excluded. Of the 255 patients with PSP treated with chest tube insertion, 172 patients were enrolled in this study. Twenty-nine (16.9%) had fissural tube placement and 143 (83.1%) had pleural tube placement. A higher proportion of patients in the fissural versus pleural group required additional chest tube insertion (20.7% vs 4.9%, P = 0.010, respectively). There was no significant difference in body mass index, smoker status, symptom duration, number of episodes, post-thoracostomy complications, need for subsequent management, and duration of hospitalization in either group. In closed thoracostomy for PSP, there is a higher chance of tube dysfunction when the chest tube is positioned at fissural area as compared with the pleural space.

  6. Geoscience Australia Continuous Global Positioning System (CGPS) Station Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Ruddick, R. [Geoscience Australia, Symonston (Australia); Twilley, B. [Geoscience Australia, Symonston (Australia)

    2016-03-01

    This station formed part of the Australian Regional GPS Network (ARGN) and South Pacific Regional GPS Network (SPRGN), which is a network of continuous GPS stations operating within Australia and its Territories (including Antarctica) and the Pacific. These networks support a number of different science applications including maintenance of the Geospatial Reference Frame, both national and international, continental and tectonic plate motions, sea level rise, and global warming.

  7. Dialogical Self Theory and the increasing multiplicity of I-positions in a globalizing society: an introduction.

    Science.gov (United States)

    Hermans, Hubert J M

    2012-01-01

    Dialogical Self Theory is a recent development in the social sciences, based on a conception of the self as a society of mind. In this conception, the self is considered as extended to significant others in the environment, who populate the self as a dynamic multiplicity of I-positions between which dialogical or monological relationships may emerge. While from a spatial perspective the self is engaged in a process of positioning and counterpositioning in a globalizing society, from a temporal point of view the self is part of a process of positioning and repositioning in collective history and personal development. Some phenomena that are necessary for the understanding of the dialogical self are discussed: dominance and social power, the processes of globalization and localization, the experience of uncertainty and possible reactions to uncertainty in a globalizing world. Finally, the different contributions of this special issue are placed in the context of the presented conceptual framework. Copyright © 2012 Wiley Periodicals, Inc., A Wiley Company.

  8. Fruits and vegetables intake differentially affects estrogen receptor negative and positive breast cancer incidence rates.

    Science.gov (United States)

    Olsen, Anja; Tjønneland, Anne; Thomsen, Birthe L; Loft, Steffen; Stripp, Connie; Overvad, Kim; Møller, Susanne; Olsen, Jørgen H

    2003-07-01

    Despite intensive research, the evidence for a protective effect of fruits and vegetables on breast cancer risk remains inconclusive. Other risk factors for breast cancer seem to vary with the estrogen receptor status of the breast tumor, and it is thus possible that the inconsistent results regarding a preventive effect of fruits and vegetables are due to lack of controlling for estrogen receptor status. The objective of this study was to investigate the effect of fruit and vegetable intake on postmenopausal breast cancer and explore whether the estrogen receptor status of the tumor modifies this relation. Postmenopausal women (n = 23,798; aged 50-64 y) provided information about diet and established risk factors for breast cancer in the cohort "Diet, Cancer and Health." During follow-up, 425 cases were diagnosed with breast cancer. Associations between intake of fruits and vegetables and the breast cancer rate were analyzed using Cox's regression model. The association for all breast cancers was an incidence rate ratio (IRR) of 1.02 (95% CI, 0.98-1.06) per 100 g/d increment of total intake of fruits, vegetables and juice. For estrogen receptor-positive (ER(+)) breast cancer, a borderline significant increase in the rate was seen, IRR: 1.05 (95% CI, 1.00-1.10), whereas a preventive effect was seen for estrogen receptor-negative (ER(-)) breast cancers, IRR: 0.90 (95% CI, 0.81-0.99). In conclusion, we did not find the overall breast cancer rate to be associated with the intake of fruits and vegetables, but there seemed to be different effects for ER(+) and ER(-) breast cancer.

  9. Differential strengths of positive selection revealed by hitchhiking effects at small physical scales in Drosophila melanogaster.

    Science.gov (United States)

    Lee, Yuh Chwen G; Langley, Charles H; Begun, David J

    2014-04-01

    The long time scale of adaptive evolution makes it difficult to directly observe the spread of most beneficial mutations through natural populations. Therefore, inferring attributes of beneficial mutations by studying the genomic signals left by directional selection is an important component of population genetics research. One kind of signal is a trough in nearby neutral genetic variation due to selective fixation of initially rare alleles, a phenomenon known as "genetic hitchhiking." Accumulated evidence suggests that a considerable fraction of substitutions in the Drosophila genome results from positive selection, most of which are expected to have small selection coefficients and influence the population genetics of sites in the immediate vicinity. Using Drosophila melanogaster population genomic data, we found that the heterogeneity in synonymous polymorphism surrounding different categories of coding fixations is readily observable even within 25 bp of focal substitutions, which we interpret as the result of small-scale hitchhiking effects. The strength of natural selection on different sites appears to be quite heterogeneous. Particularly, neighboring fixations that changed amino acid polarities in a way that maintained the overall polarities of a protein were under stronger selection than other categories of fixations. Interestingly, we found that substitutions in slow-evolving genes are associated with stronger hitchhiking effects. This is consistent with the idea that adaptive evolution may involve few substitutions with large effects or many substitutions with small effects. Because our approach only weakly depends on the numbers of recent nonsynonymous substitutions, it can provide a complimentary view to the adaptive evolution inferred by other divergence-based evolutionary genetic methods.

  10. Global Positioning System surveys of storm-surge sensors deployed during Hurricane Ike, Seadrift, Texas, to Lake Charles, Louisiana, 2008

    Science.gov (United States)

    Payne, Jason; Woodward, Brenda K.; Storm, John B.

    2009-01-01

    The U.S. Geological Survey installed a network of pressure sensors at 65 sites along the Gulf Coast from Seadrift, Texas, northeast to Lake Charles, Louisiana, to record the timing, areal extent, and magnitude of inland storm surge and coastal flooding caused by Hurricane Ike in September 2008. A Global Positioning System was used to obtain elevations of reference marks near each sensor. A combination of real-time kinematic (RTK) and static Global Positioning System surveys were done to obtain elevations of reference marks. Leveling relative to reference marks was done to obtain elevations of sensor orifices above the reference marks. This report summarizes the Global Positioning System data collected and processed to obtain reference mark and storm-sensor-orifice elevations for 59 storm-surge sensors recovered from the original 65 installed as a necessary prelude to computation of storm-surge elevations. National Geodetic Survey benchmarks were used for RTK surveying. Where National Geodetic Survey benchmarks were not within 12 kilometers of a sensor site, static surveying was done. Additional control points for static surveying were in the form of newly established benchmarks or reestablished existing benchmarks. RTK surveying was used to obtain positions and elevations of reference marks for 29 sensor sites. Static surveying was used to obtain positions and elevations of reference marks for 34 sensor sites; four sites were surveyed using both methods. Multiple quality checks on the RTK-survey and static-survey data were applied. The results of all quality checks indicate that the desired elevation accuracy for the surveys of this report, less than 0.1-meter error, was achieved.

  11. Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation

    NARCIS (Netherlands)

    Bastos Sales, L.; Kamstra, J. H.; Cenijn, P. H.; van Rijt, L. S.; Hamers, T.; Legler, J.

    2013-01-01

    Recent studies suggest that endocrine disrupting chemicals (EDCs) may form a risk factor for obesity by altering energy metabolism through epigenetic gene regulation. The goal of this study is to investigate the effects of a range of EDCs with putative obesogenic properties on global DNA methylation

  12. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

    Directory of Open Access Journals (Sweden)

    Aline Meulle

    Full Text Available Little information is available on the ability of terminally differentiated cells to efficiently repair DNA double strand breaks (DSBs, and one might reasonably speculate that efficient DNA repair of these threatening DNA lesions, is needed in cells of long life span with no or limited regeneration from precursor. Few tissues are available besides neurons that allow the study of DNA DSBs repair activity in very long-lived cells. Adipocytes represent a suitable model since it is generally admitted that there is a very slow turnover of adipocytes in adult. Using both Pulse Field Gel Electrophoresis (PFGE and the disappearance of the phosphorylated form of the histone variant H2AX, we demonstrated that the ability to repair DSBs is increased during adipocyte differentiation using the murine pre-adipocyte cell line, 3T3F442A. In mammalian cells, DSBs are mainly repaired by the non-homologous end-joining pathway (NHEJ that relies on the DNA dependent protein kinase (DNA-PK activity. During the first 24 h following the commitment into adipogenesis, we show an increase in the expression and activity of the catalytic sub-unit of the DNA-PK complex, DNA-PKcs. The increased in DNA DSBs repair activity observed in adipocytes was due to the increase in DNA-PK activity as shown by the use of DNA-PK inhibitor or sub-clones of 3T3F442A deficient in DNA-PKcs using long term RNA interference. Interestingly, the up-regulation of DNA-PK does not regulate the differentiation program itself. Finally, similar positive regulation of DNA-PKcs expression and activity was observed during differentiation of primary culture of pre-adipocytes isolated from human sub-cutaneous adipose tissue. Our results show that DNA DSBs repair activity is up regulated during the early commitment into adipogenesis due to an up-regulation of DNA-PK expression and activity. In opposition to the general view that DNA DSBs repair is decreased during differentiation, our results demonstrate

  13. Globalization

    OpenAIRE

    Andru?cã Maria Carmen

    2013-01-01

    The field of globalization has highlighted an interdependence implied by a more harmonious understanding determined by the daily interaction between nations through the inducement of peace and the management of streamlining and the effectiveness of the global economy. For the functioning of the globalization, the developing countries that can be helped by the developed ones must be involved. The international community can contribute to the institution of the development environment of the gl...

  14. Coupled Global and Targeted Proteomics of Human Embryonic Stem Cells during Induced Differentiation*S⃞

    OpenAIRE

    Yocum, Anastasia K.; Gratsch, Theresa E.; Leff, Nancy; Strahler, John R.; Hunter, Christie L.; Walker, Angela K.; Michailidis, George; Omenn, Gilbert S.; O'Shea, K. Sue; Andrews, Philip C.

    2008-01-01

    Elucidating the complex combinations of growth factors and signaling molecules that maintain pluripotency or, alternatively, promote the controlled differentiation of human embryonic stem cells (hESCs) has important implications for the fundamental understanding of human development, devising cell replacement therapies, and cancer cell biology. hESCs are commonly grown on irradiated mouse embryonic fibroblasts (MEFs) or in conditioned medium from MEFs. These culture conditions interfere with ...

  15. Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma

    Directory of Open Access Journals (Sweden)

    Primerano Donald A

    2008-10-01

    Full Text Available Abstract Background The incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are susceptible to the growth inhibitory and pro-differentiating effects of all-trans-retinoic acid (RA. The molecular changes responsible for the biological activity of RA in melanoma are not well understood. Results In an analysis of sequential global gene expression changes during a 4–48 h RA treatment of B16 mouse melanoma cells, we found that RA increased the expression of 757 genes and decreased the expression of 737 genes. We also compared the gene expression profile (no RA treatment between non-malignant melan-a mouse melanocytes and B16 melanoma cells. Using the same statistical test, we found 1495 genes whose expression was significantly higher in melan-a than in B16 cells and 2054 genes whose expression was significantly lower in melan-a than in B16 cells. By intersecting these two gene sets, we discovered a common set of 233 genes whose RNA levels were significantly different between B16 and melan-a cells and whose expression was altered by RA treatment. Within this set, RA treatment altered the expression of 203 (87% genes toward the melan-a expression level. In addition, hierarchical clustering showed that after 48 h of RA treatment expression of the 203 genes was more closely related to the melan-a gene set than any other RA treatment time point. Functional analysis of the 203 gene set indicated that RA decreased expression of mRNAs that encode proteins involved in cell division/cell cycle, DNA replication, recombination and repair, and transcription regulation. Conversely, it stimulated genes involved in cell-cell signaling, cell adhesion and cell differentiation/embryonic development. Pathway analysis of the 203 gene set revealed four major hubs of connectivity: CDC2, CHEK1, CDC45L and MCM6. Conclusion Our analysis of common genes in the 48 h RA-treatment of B16 melanoma cells and untreated B16

  16. The absence of global positive solutions of systems of semilinear elliptic inequalities in cones

    International Nuclear Information System (INIS)

    Laptev, G G

    2000-01-01

    Let K be a cone in R N , N>=2. We establish conditions for the absence of global non-trivial non-negative solutions of semilinear elliptic inequalities and systems of inequalities of the form -div(|x| α Du)>=|x| β u q , u| ∂K =0. We find the critical exponent q* that divides the domains of existence of these solutions from those of their absence. We prove that in the limiting case q=q* there are no solutions. The method is to multiply the system by a special factor and integrate the inequalities thus obtained

  17. Global asymptotic stabilization of large-scale hydraulic networks using positive proportional controls

    DEFF Research Database (Denmark)

    Jensen, Tom Nørgaard; Wisniewski, Rafal

    2014-01-01

    An industrial case study involving a large-scale hydraulic network underlying a district heating system subject to structural changes is considered. The problem of controlling the pressure drop across the so-called end-user valves in the network to a designated vector of reference values under......-users. Furthermore, by a proper design of controller gains the closed-loop equilibrium point can be designed to belong to an arbitrarily small neighborhood of the desired equilibrium point. Since there exists a globally asymptotically stable equilibrium point independently on the number of end-users in the system...

  18. Global trophic position comparison of two dominant mesopelagic fish families (Myctophidae, Stomiidae using amino acid nitrogen isotopic analyses.

    Directory of Open Access Journals (Sweden)

    C Anela Choy

    Full Text Available The δ(15N values of organisms are commonly used across diverse ecosystems to estimate trophic position and infer trophic connectivity. We undertook a novel cross-basin comparison of trophic position in two ecologically well-characterized and different groups of dominant mid-water fish consumers using amino acid nitrogen isotope compositions. We found that trophic positions estimated from the δ(15N values of individual amino acids are nearly uniform within both families of these fishes across five global regions despite great variability in bulk tissue δ(15N values. Regional differences in the δ(15N values of phenylalanine confirmed that bulk tissue δ(15N values reflect region-specific water mass biogeochemistry controlling δ(15N values at the base of the food web. Trophic positions calculated from amino acid isotopic analyses (AA-TP for lanternfishes (family Myctophidae (AA-TP ∼2.9 largely align with expectations from stomach content studies (TP ∼3.2, while AA-TPs for dragonfishes (family Stomiidae (AA-TP ∼3.2 were lower than TPs derived from stomach content studies (TP∼4.1. We demonstrate that amino acid nitrogen isotope analysis can overcome shortcomings of bulk tissue isotope analysis across biogeochemically distinct systems to provide globally comparative information regarding marine food web structure.

  19. Differential responses of Miocene rodent metacommunities to global climatic changes were mediated by environmental context.

    Science.gov (United States)

    Blanco, Fernando; Gómez Cano, Ana Rosa; Cantalapiedra, Juan L; Domingo, M Soledad; Domingo, Laura; Menéndez, Iris; Flynn, Lawrence J; Hernández Fernández, Manuel

    2018-02-06

    The study of how long-term changes affect metacommunities is a relevant topic, that involves the evaluation of connections among biological assemblages across different spatio-temporal scales, in order to fully understand links between global changes and macroevolutionary patterns. We applied multivariate statistical analyses and diversity tests using a large data matrix of rodent fossil sites in order to analyse long-term faunal changes. Late Miocene rodent faunas from southwestern Europe were classified into metacommunities, presumably sharing ecological affinities, which followed temporal and environmental non-random assembly and disassembly patterns. Metacommunity dynamics of these faunas were driven by environmental changes associated with temperature variability, but there was also some influence from the aridity shifts described for this region during the late Miocene. Additionally, while variations in the structure of rodent assemblages were directly influenced by global climatic changes in the southern province, the northern sites showed a pattern of climatic influence mediated by diversity-dependent processes.

  20. Non-existence of global solutions to generalized dissipative Klein-Gordon equations with positive energy

    Directory of Open Access Journals (Sweden)

    Maxim Olegovich Korpusov

    2012-07-01

    Full Text Available In this article the initial-boundary-value problem for generalized dissipative high-order equation of Klein-Gordon type is considered. We continue our study of nonlinear hyperbolic equations and systems with arbitrary positive energy. The modified concavity method by Levine is used for proving blow-up of solutions.

  1. Comparative Sex Chromosome Genomics in Snakes: Differentiation, Evolutionary Strata, and Lack of Global Dosage Compensation

    Science.gov (United States)

    Zektser, Yulia; Mahajan, Shivani; Bachtrog, Doris

    2013-01-01

    Snakes exhibit genetic sex determination, with female heterogametic sex chromosomes (ZZ males, ZW females). Extensive cytogenetic work has suggested that the level of sex chromosome heteromorphism varies among species, with Boidae having entirely homomorphic sex chromosomes, Viperidae having completely heteromorphic sex chromosomes, and Colubridae showing partial differentiation. Here, we take a genomic approach to compare sex chromosome differentiation in these three snake families. We identify homomorphic sex chromosomes in boas (Boidae), but completely heteromorphic sex chromosomes in both garter snakes (Colubridae) and pygmy rattlesnake (Viperidae). Detection of W-linked gametologs enables us to establish the presence of evolutionary strata on garter and pygmy rattlesnake sex chromosomes where recombination was abolished at different time points. Sequence analysis shows that all strata are shared between pygmy rattlesnake and garter snake, i.e., recombination was abolished between the sex chromosomes before the two lineages diverged. The sex-biased transmission of the Z and its hemizygosity in females can impact patterns of molecular evolution, and we show that rates of evolution for Z-linked genes are increased relative to their pseudoautosomal homologs, both at synonymous and amino acid sites (even after controlling for mutational biases). This demonstrates that mutation rates are male-biased in snakes (male-driven evolution), but also supports faster-Z evolution due to differential selective effects on the Z. Finally, we perform a transcriptome analysis in boa and pygmy rattlesnake to establish baseline levels of sex-biased expression in homomorphic sex chromosomes, and show that heteromorphic ZW chromosomes in rattlesnakes lack chromosome-wide dosage compensation. Our study provides the first full scale overview of the evolution of snake sex chromosomes at the genomic level, thus greatly expanding our knowledge of reptilian and vertebrate sex chromosomes

  2. Numerical approximations of stochastic differential equations with non-globally Lipschitz continuous coefficients

    CERN Document Server

    Hutzenthaler, Martin

    2015-01-01

    Many stochastic differential equations (SDEs) in the literature have a superlinearly growing nonlinearity in their drift or diffusion coefficient. Unfortunately, moments of the computationally efficient Euler-Maruyama approximation method diverge for these SDEs in finite time. This article develops a general theory based on rare events for studying integrability properties such as moment bounds for discrete-time stochastic processes. Using this approach, the authors establish moment bounds for fully and partially drift-implicit Euler methods and for a class of new explicit approximation method

  3. Differentiation, international equity and efficiency in the fight against the global climatic change

    International Nuclear Information System (INIS)

    Blanchard, O.; Criqui, P.; Viguier, L.; Trommetter, M.

    1998-05-01

    The first difficulty to get over in the international negotiation on the climatic change, has been and still remain the distribution of the efforts and the research of the equity in the objective determination. This paper analyzes the possible consequences of the negotiable emission licenses in terms of efficiency and equity. The first part is a review of the different charts of the objectives differentiation discussed or proposed in the international negotiation process on the greenhouse effect. It aims to find a bond between the the charts and the equity. The second part deals with the programs cost and their relative efficiency, taking into account the marginal cost curves. (A.L.B.)

  4. Evaluation of Basketball-Specific Agility: Applicability of Preplanned and Nonplanned Agility Performances for Differentiating Playing Positions and Playing Levels.

    Science.gov (United States)

    Sekulic, Damir; Pehar, Miran; Krolo, Ante; Spasic, Miodrag; Uljevic, Ognjen; Calleja-González, Julio; Sattler, Tine

    2017-08-01

    Sekulic, D, Pehar, M, Krolo, A, Spasic, M, Uljevic, O, Calleja-González, J, and Sattler, T. Evaluation of basketball-specific agility: applicability of preplanned and nonplanned agility performances for differentiating playing positions and playing levels. J Strength Cond Res 31(8): 2278-2288, 2017-The importance of agility in basketball is well known, but there is an evident lack of studies examining basketball-specific agility performances in high-level players. The aim of this study was to determine the reliability and discriminative validity of 1 standard agility test (test of preplanned agility [change-of-direction speed] over T course, T-TEST), and 4 newly developed basketball-specific agility tests, in defining playing positions and performance levels in basketball. The study comprised 110 high-level male basketball players (height: 194.92 ± 8.09 cm; body mass: 89.33 ± 10.91 kg; age: 21.58 ± 3.92 years). The variables included playing position (Guard, Forward, Center), performance level (first division vs. second division), anthropometrics (body height, body mass, and percentage of body fat), T-TEST, nonplanned basketball agility test performed on dominant (BBAGILdom) and nondominant sides (BBAGILnond), and a preplanned (change-of-direction speed) basketball agility test performed on dominant (BBCODSdom) and nondominant sides (BBCODSnond). The reliability of agility tests was high (intraclass correlation coefficient of 0.81-0.95). Forwards were most successful in the T-TEST (F test: 13.57; p = 0.01). Guards outperformed Centers in BBCODSdom, BBCODSndom, BBAGILdom, and BBAGILnond (F test: 5.06, p = 0.01; 6.57, 0.01; 6.26, 0.01; 3.37, 0.04, respectively). First division Guards achieved better results than second division Guards in BBCODSdom (t: 2.55; p = 0.02; moderate effect size differences), BBAGILdom, and BBAGILnond (t: 3.04 and 3.06, respectively; both p = 0.01 and moderate effect size differences). First division Centers outperformed second division

  5. B cell differentiation in EBV-positive Burkitt Lymphoma is impaired at post-transcriptional level by miRNA altered expression

    DEFF Research Database (Denmark)

    Leucci, E; Onnis, A; Cocco, M

    2009-01-01

    investigated the expression of specific miRNAs predicted to be involved in B cell differentiation and we found that hsa-miR-127 is differentially expressed between EBV-positive and EBV-negative BLs. In particular, it was strongly up-regulated only in EBV-positive BL samples, whereas EBV-negative cases showed...... levels of expression similar to normal controls, including microdissected GC cells.In addition, we found evidence that hsa-miR-127 is involved in B cell differentiation process through post transcriptional regulation of BLIMP1 and XBP1. The over-expression of this miRNA may thus represent a key event...

  6. Global positioning system derived performance measures are responsive indicators of physical activity, disease and the success of clinical treatments in domestic dogs.

    Directory of Open Access Journals (Sweden)

    Elizabeth A Bruno

    Full Text Available To assess the use of Global Positioning System receiver (GPS derived performance measures for differentiating between: 1 different outdoor activities in healthy dogs; 2 healthy dogs and those with osteoarthritis; 3 osteoarthritic dogs before and after treatment with non-steroidal anti-inflammatory analgesia.Prospective study.Ten healthy dogs and seven dogs with osteoarthritis of the elbow joint (OA dogs.Healthy dogs were walked on a standard route on-lead, off-lead and subjected to playing activity (chasing a ball whilst wearing a GPS collar. Each dog was walked for five consecutive days. Dogs with OA were subjected to a single off-lead walk whilst wearing a GPS collar, and then administered oral Carprofen analgesia daily for two weeks. OA dogs were then subjected to the same walk, again wearing a GPS collar.GPS derived measures of physical performance could differentiate between on-lead activity, off-lead activity and playing activity in healthy dogs, and between healthy dogs and OA dogs. Variation in the performance measures analysed was greater between individual dogs than for individual dogs on different days. Performance measures could differentiate healthy dogs from OA dogs. OA Dogs treated with Carprofen analgesia showed improvements in their physical performance, which returned to values indistinguishable from those of healthy dogs on nearly all the measures assessed.GPS derived measures of physical performance in dogs are objective, easy to quantify, and can be used to gauge the effects of disease and success of clinical treatments. Specific stimuli can be used to modulate physical performance beyond the self-governed boundaries that dogs will naturally express when allowed to exercise freely without stimulation.

  7. Control Information and Data Processing of Vehicle based on Global Position System

    OpenAIRE

    Shupeng Zhao; Miao Tian; Shifang Zhang; Jiuxi Li

    2013-01-01

    A testing system based on Data Stream function of vehicle electronic control system was developed to test the city bus driving cycle. A mufti-function Vehicle Traveling Data Recorder based on GPS which can realize the vehicles positioning and navigating was investigated. The system included data acquisition module, display module, print module, GPS module, communication module and so on. This system adopts the FRAM memory as the storing equipment in which the automobile realized the real-time...

  8. The Influence of Playing Position and Contextual Factors on Soccer Players’ Match Differential Ratings of Perceived Exertion: A Preliminary Investigation

    Directory of Open Access Journals (Sweden)

    Steve Barrett

    2018-02-01

    Full Text Available (1 Background: Differential RPE (dRPE separates scores for breathlessness (RPE-B, leg muscle exertion (RPE-L and technical/cognitive exertion (RPE-T. Limited information for dRPE is available in soccer match play, yet these measurements may help inform practitioners training and recovery strategies. This preliminary study investigated the effects of playing position and contextual factors on elite soccer players’ dRPE. (2 Methods: Thirty-two male English Premier League players recorded dRPE scores 15–30 min post-match for RPE-B, RPE-L, and RPE-T. Data were analysed using linear mixed models, with magnitude-based inferences subsequently applied. (3 Results: Overall, the mean ± SD for the dRPE were 63 ± 23 arbitrary units (au (RPE-B, 67 ± 22 au (RPE-L, and 60 ± 24 au (RPE-T. Full Backs reported substantially higher RPE-B, RPE-L and RPE-T when compared to all other positions. Substantially higher RPE-T scores were reported for matches played against Top teams compared to Bottom (10 au; 90% Confidence Interval 5 to 15 au and Middle (10 au; 4 to 15 au ranked teams. The effects of match result and location on dRPE were not substantial. (4 Conclusions: Positional differences were observed following soccer match play for RPE-B, RPE-L and RPE-T. Full backs had substantially higher dRPE then any other position, with all players reporting increased RPE-T when playing teams at the Top of the league. These findings can help practitioners monitor internal load responses and support the prescription of training and recovery sessions.

  9. A Global Multi-Objective Optimization Tool for Design of Mechatronic Components using Generalized Differential Evolution

    DEFF Research Database (Denmark)

    Bech, Michael Møller; Nørgård, Christian; Roemer, Daniel Beck

    2016-01-01

    This paper illustrates how the relatively simple constrained multi-objective optimization algorithm Generalized Differential Evolution 3 (GDE3), can assist with the practical sizing of mechatronic components used in e.g. digital displacement fluid power machinery. The studied bi- and tri-objectiv...... different optimization control parameter settings and it is concluded that GDE3 is a reliable optimization tool that can assist mechatronic engineers in the design and decision making process.......This paper illustrates how the relatively simple constrained multi-objective optimization algorithm Generalized Differential Evolution 3 (GDE3), can assist with the practical sizing of mechatronic components used in e.g. digital displacement fluid power machinery. The studied bi- and tri......-objective problems having 10+ design variables are both highly constrained, nonlinear and non-smooth but nevertheless the algorithm converges to the Pareto-front within a hours of computation (20k function evaluations). Additionally, the robustness and convergence speed of the algorithm are investigated using...

  10. Additional Insights Into Problem Definition and Positioning From Social Science Comment on "Four Challenges That Global Health Networks Face".

    Science.gov (United States)

    Quissell, Kathryn

    2017-09-10

    Commenting on a recent editorial in this journal which presented four challenges global health networks will have to tackle to be effective, this essay discusses why this type of analysis is important for global health scholars and practitioners, and why it is worth understanding and critically engaging with the complexities behind these challenges. Focusing on the topics of problem definition and positioning, I outline additional insights from social science theory to demonstrate how networks and network researchers can evaluate these processes, and how these processes contribute to better organizing, advocacy, and public health outcomes. This essay also raises multiple questions regarding these processes for future research. © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  11. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis

    Science.gov (United States)

    Ward, Nicholas D.; Cosner, Diane E.; Lamb, Colleen A.; Li, Wei; Macknis, Jacqueline K.; Rooney, Michele T.; Zhang, Ping L.

    2014-01-01

    A rat model of antineutrophil cytoplasmic antibody (ANCA) associated vasculitides reveals crescentic glomerulonephritis as seen in human renal biopsies and diffuse lung hemorrhage that is not well documented in human lung biopsies. A 64-year-old male, with shortness of breath and mild elevation of serum creatinine, was found to have a positive serum test for ANCA, but negative antiglomerular basement membrane antibody. A renal biopsy showed pauci-immune type of crescentic glomerulonephritis and focal arteritis. The prior lung wedge biopsy was retrospectively reviewed to show diffuse hemorrhage and hemosiderosis with focal giant cells. In addition, small arteries revealed subtle neutrophil aggregation, and margination along vascular endothelium, but no definitive vasculitis. The pathology of ANCA associated vasculitides results from activated neutrophils by ANCA and subsequent activation of the alternative complement cascade with endothelial injury, neutrophil aggregation and margination. Our findings, after the correlation between lung biopsy and renal biopsy, imply that the top differential diagnosis in the lung biopsy should be microscopic polyangiitis when diffuse pulmonary hemorrhage and hemosiderosis are present in this ANCA-positive patient. PMID:25525543

  12. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis

    Directory of Open Access Journals (Sweden)

    Nicholas D. Ward

    2014-01-01

    Full Text Available A rat model of antineutrophil cytoplasmic antibody (ANCA associated vasculitides reveals crescentic glomerulonephritis as seen in human renal biopsies and diffuse lung hemorrhage that is not well documented in human lung biopsies. A 64-year-old male, with shortness of breath and mild elevation of serum creatinine, was found to have a positive serum test for ANCA, but negative antiglomerular basement membrane antibody. A renal biopsy showed pauci-immune type of crescentic glomerulonephritis and focal arteritis. The prior lung wedge biopsy was retrospectively reviewed to show diffuse hemorrhage and hemosiderosis with focal giant cells. In addition, small arteries revealed subtle neutrophil aggregation, and margination along vascular endothelium, but no definitive vasculitis. The pathology of ANCA associated vasculitides results from activated neutrophils by ANCA and subsequent activation of the alternative complement cascade with endothelial injury, neutrophil aggregation and margination. Our findings, after the correlation between lung biopsy and renal biopsy, imply that the top differential diagnosis in the lung biopsy should be microscopic polyangiitis when diffuse pulmonary hemorrhage and hemosiderosis are present in this ANCA-positive patient.

  13. Global changes in transcription orchestrate metabolic differentiation during symbiotic nitrogen fixation in Lotus japonicus

    DEFF Research Database (Denmark)

    Colebatch, Gillian; Desbrosses, Guilhem; Ott, Thomas

    2004-01-01

    from specific sets of induced genes. In addition to the expected signs of hypoxia, numerous indications were obtained that nodule cells also experience P-limitation and osmotic stress. Several potential regulators of these stress responses were identified. Metabolite profiling by gas chromatography......Research on legume nodule metabolism has contributed greatly to our knowledge of primary carbon and nitrogen metabolism in plants in general, and in symbiotic nitrogen fixation in particular. However, most previous studies focused on one or a few genes/enzymes involved in selected metabolic...... pathways in many different legume species. We utilized the tools of transcriptomics and metabolomics to obtain an unprecedented overview of the metabolic differentiation that results from nodule development in the model legume, Lotus japonicus. Using an array of more than 5000 nodule cDNA clones...

  14. Computationally efficient visual–inertial sensor fusion for Global Positioning System–denied navigation on a small quadrotor

    Directory of Open Access Journals (Sweden)

    Chang Liu

    2016-03-01

    Full Text Available Because of the complementary nature of visual and inertial sensors, the combination of both is able to provide fast and accurate 6 degree-of-freedom state estimation, which is the fundamental requirement for robotic (especially, unmanned aerial vehicle navigation tasks in Global Positioning System–denied environments. This article presents a computationally efficient visual–inertial fusion algorithm, by separating orientation fusion from the position fusion process. The algorithm is designed to perform 6 degree-of-freedom state estimation, based on a gyroscope, an accelerometer and a monocular visual-based simultaneous localisation and mapping algorithm measurement. It also recovers the visual scale for the monocular visual-based simultaneous localisation and mapping. In particular, the fusion algorithm treats the orientation fusion and position fusion as two separate processes, where the orientation fusion is based on a very efficient gradient descent algorithm, whereas the position fusion is based on a 13-state linear Kalman filter. The elimination of the magnetometer sensor avoids the problem of magnetic distortion, which makes it a power-on-and-go system once the accelerometer is factory calibrated. The resulting algorithm shows a significant computational reduction over the conventional extended Kalman filter, with competitive accuracy. Moreover, the separation between orientation and position fusion processes enables the algorithm to be easily implemented onto two individual hardware elements and thus allows the two fusion processes to be executed concurrently.

  15. Existence and Global Asymptotic Behavior of Positive Solutions for Nonlinear Fractional Dirichlet Problems on the Half-Line

    Directory of Open Access Journals (Sweden)

    Imed Bachar

    2014-01-01

    Full Text Available We are interested in the following fractional boundary value problem: Dαu(t+atuσ=0, t∈(0,∞, limt→0⁡t2-αu(t=0, limt→∞⁡t1-αu(t=0, where 1<α<2, σ∈(-1,1, Dα is the standard Riemann-Liouville fractional derivative, and a is a nonnegative continuous function on (0,∞ satisfying some appropriate assumptions related to Karamata regular variation theory. Using the Schauder fixed point theorem, we prove the existence and the uniqueness of a positive solution. We also give a global behavior of such solution.

  16. GNSS global real-time augmentation positioning: Real-time precise satellite clock estimation, prototype system construction and performance analysis

    Science.gov (United States)

    Chen, Liang; Zhao, Qile; Hu, Zhigang; Jiang, Xinyuan; Geng, Changjiang; Ge, Maorong; Shi, Chuang

    2018-01-01

    Lots of ambiguities in un-differenced (UD) model lead to lower calculation efficiency, which isn't appropriate for the high-frequency real-time GNSS clock estimation, like 1 Hz. Mixed differenced model fusing UD pseudo-range and epoch-differenced (ED) phase observations has been introduced into real-time clock estimation. In this contribution, we extend the mixed differenced model for realizing multi-GNSS real-time clock high-frequency updating and a rigorous comparison and analysis on same conditions are performed to achieve the best real-time clock estimation performance taking the efficiency, accuracy, consistency and reliability into consideration. Based on the multi-GNSS real-time data streams provided by multi-GNSS Experiment (MGEX) and Wuhan University, GPS + BeiDou + Galileo global real-time augmentation positioning prototype system is designed and constructed, including real-time precise orbit determination, real-time precise clock estimation, real-time Precise Point Positioning (RT-PPP) and real-time Standard Point Positioning (RT-SPP). The statistical analysis of the 6 h-predicted real-time orbits shows that the root mean square (RMS) in radial direction is about 1-5 cm for GPS, Beidou MEO and Galileo satellites and about 10 cm for Beidou GEO and IGSO satellites. Using the mixed differenced estimation model, the prototype system can realize high-efficient real-time satellite absolute clock estimation with no constant clock-bias and can be used for high-frequency augmentation message updating (such as 1 Hz). The real-time augmentation message signal-in-space ranging error (SISRE), a comprehensive accuracy of orbit and clock and effecting the users' actual positioning performance, is introduced to evaluate and analyze the performance of GPS + BeiDou + Galileo global real-time augmentation positioning system. The statistical analysis of real-time augmentation message SISRE is about 4-7 cm for GPS, whlile 10 cm for Beidou IGSO/MEO, Galileo and about 30 cm

  17. Differential Globalization of Industry- and Non-Industry–Sponsored Clinical Trials

    Science.gov (United States)

    Atal, Ignacio; Trinquart, Ludovic; Porcher, Raphaël; Ravaud, Philippe

    2015-01-01

    Background Mapping the international landscape of clinical trials may inform global health research governance, but no large-scale data are available. Industry or non-industry sponsorship may have a major influence in this mapping. We aimed to map the global landscape of industry- and non-industry–sponsored clinical trials and its evolution over time. Methods We analyzed clinical trials initiated between 2006 and 2013 and registered in the WHO International Clinical Trials Registry Platform (ICTRP). We mapped single-country and international trials by World Bank's income groups and by sponsorship (industry- vs. non- industry), including its evolution over time from 2006 to 2012. We identified clusters of countries that collaborated significantly more than expected in industry- and non-industry–sponsored international trials. Results 119,679 clinical trials conducted in 177 countries were analysed. The median number of trials per million inhabitants in high-income countries was 100 times that in low-income countries (116.0 vs. 1.1). Industry sponsors were involved in three times more trials per million inhabitants than non-industry sponsors in high-income countries (75.0 vs. 24.5) and in ten times fewer trials in low- income countries (0.08 vs. 1.08). Among industry- and non-industry–sponsored trials, 30.3% and 3.2% were international, respectively. In the industry-sponsored network of collaboration, Eastern European and South American countries collaborated more than expected; in the non-industry–sponsored network, collaboration among Scandinavian countries was overrepresented. Industry-sponsored international trials became more inter-continental with time between 2006 and 2012 (from 54.8% to 67.3%) as compared with non-industry–sponsored trials (from 42.4% to 37.2%). Conclusions Based on trials registered in the WHO ICTRP we documented a substantial gap between the globalization of industry- and non-industry–sponsored clinical research. Only 3% of

  18. Differential Globalization of Industry- and Non-Industry-Sponsored Clinical Trials.

    Science.gov (United States)

    Atal, Ignacio; Trinquart, Ludovic; Porcher, Raphaël; Ravaud, Philippe

    2015-01-01

    Mapping the international landscape of clinical trials may inform global health research governance, but no large-scale data are available. Industry or non-industry sponsorship may have a major influence in this mapping. We aimed to map the global landscape of industry- and non-industry-sponsored clinical trials and its evolution over time. We analyzed clinical trials initiated between 2006 and 2013 and registered in the WHO International Clinical Trials Registry Platform (ICTRP). We mapped single-country and international trials by World Bank's income groups and by sponsorship (industry- vs. non- industry), including its evolution over time from 2006 to 2012. We identified clusters of countries that collaborated significantly more than expected in industry- and non-industry-sponsored international trials. 119,679 clinical trials conducted in 177 countries were analysed. The median number of trials per million inhabitants in high-income countries was 100 times that in low-income countries (116.0 vs. 1.1). Industry sponsors were involved in three times more trials per million inhabitants than non-industry sponsors in high-income countries (75.0 vs. 24.5) and in ten times fewer trials in low- income countries (0.08 vs. 1.08). Among industry- and non-industry-sponsored trials, 30.3% and 3.2% were international, respectively. In the industry-sponsored network of collaboration, Eastern European and South American countries collaborated more than expected; in the non-industry-sponsored network, collaboration among Scandinavian countries was overrepresented. Industry-sponsored international trials became more inter-continental with time between 2006 and 2012 (from 54.8% to 67.3%) as compared with non-industry-sponsored trials (from 42.4% to 37.2%). Based on trials registered in the WHO ICTRP we documented a substantial gap between the globalization of industry- and non-industry-sponsored clinical research. Only 3% of academic trials but 30% of industry trials are

  19. Global health and climate change: moving from denial and catastrophic fatalism to positive action.

    Science.gov (United States)

    Costello, Anthony; Maslin, Mark; Montgomery, Hugh; Johnson, Anne M; Ekins, Paul

    2011-05-13

    The health effects of climate change have had relatively little attention from climate scientists and governments. Climate change will be a major threat to population health in the current century through its potential effects on communicable disease, heat stress, food and water security, extreme weather events, vulnerable shelter and population migration. This paper addresses three health-sector strategies to manage the health effects of climate change-promotion of mitigation, tackling the pathways that lead to ill-health and strengthening health systems. Mitigation of greenhouse gas (GHG) emissions is affordable, and low-carbon technologies are available now or will be in the near future. Pathways to ill-health can be managed through better information, poverty reduction, technological innovation, social and cultural change and greater coordination of national and international institutions. Strengthening health systems requires increased investment in order to provide effective public health responses to climate-induced threats to health, equitable treatment of illness, promotion of low-carbon lifestyles and renewable energy solutions within health facilities. Mitigation and adaptation strategies will produce substantial benefits for health, such as reductions in obesity and heart disease, diabetes, stress and depression, pneumonia and asthma, as well as potential cost savings within the health sector. The case for mitigating climate change by reducing GHGs is overwhelming. The need to build population resilience to the global health threat from already unavoidable climate change is real and urgent. Action must not be delayed by contrarians, nor by catastrophic fatalists who say it is all too late. © 2011 Royal Society

  20. Failure to differentiate between threat-related and positive emotion cues in healthy adults with childhood interpersonal or adult trauma.

    Science.gov (United States)

    Chu, Denise A; Bryant, Richard A; Gatt, Justine M; Harris, Anthony W F

    2016-07-01

    Enhanced threat-related processing is associated with both elevated anxiety and childhood exposure to trauma. Given the paucity of evidence regarding the effects of childhood and adult trauma exposure on subsequent psychophysiological processes in the absence of psychopathology, we investigated the relative impacts of childhood interpersonal and non-interpersonal trauma, as well as adult trauma exposure on neural processing of threat in healthy adults. We measured peak amplitudes of the N170 face-sensitive visual ERP component response to non-conscious and conscious Angry (threat) versus Happy (non-threat, positive) and Neutral (non-threat baseline) faces at temporo-occipital sites (right-T6; left-T5) in 489 psychiatrically asymptomatic adults (aged 18-70 years, 54% women, 94% right-handed). N170 peak amplitude differences between Angry vs Happy or Neutral faces were calculated and subjected to hierarchical multiple regression analysis, with trauma types (childhood interpersonal, childhood non-interpersonal and adult trauma) entered as predictors of interest. After controlling for sociodemographic and health factors, N170 peak amplitudes for non-conscious Angry vs Happy faces were inversely associated with childhood interpersonal trauma at T6 and adult trauma exposure at T5. Post-hoc repeated measures ANOVA indicated that unlike adults without trauma exposure, trauma-exposed adults failed to show significantly reduced N170 responses to Happy relative to Angry faces during non-conscious processing. This suggests that childhood interpersonal and adult trauma exposure are associated with a failure to differentiate between non-threat or positive and threat-related emotion cues. This is consistent with generalised hypervigilance seen in PTSD, and suggests trauma exposure is associated with a generalized heightened responsivity to non-conscious non-threat or positive as well as threat-related emotion cues in psychiatrically healthy adults. Copyright © 2016 Elsevier Ltd

  1. Visual-based simultaneous localization and mapping and global positioning system correction for geo-localization of a mobile robot

    International Nuclear Information System (INIS)

    Berrabah, Sid Ahmed; Baudoin, Yvan; Sahli, Hichem

    2011-01-01

    This paper introduces an approach combining visual-based simultaneous localization and mapping (V-SLAM) and global positioning system (GPS) correction for accurate multi-sensor localization of an outdoor mobile robot in geo-referenced maps. The proposed framework combines two extended Kalman filters (EKF); the first one, referred to as the integration filter, is dedicated to the improvement of the GPS localization based on data from an inertial navigation system and wheels' encoders. The second EKF implements the V-SLAM process. The linear and angular velocities in the dynamic model of the V-SLAM EKF filter are given by the GPS/INS/Encoders integration filter. On the other hand, the output of the V-SLAM EKF filter is used to update the dynamics estimation in the integration filter and therefore the geo-referenced localization. This solution increases the accuracy and the robustness of the positioning during GPS outage and allows SLAM in less featured environments

  2. On the Global Structure of the Set of Positive Solutions of Some Semilinear Elliptic Boundary Value Problems

    Science.gov (United States)

    Fraile, J. M.; Lopezgomez, J.; Delis, J. C.

    1995-11-01

    In this work we analyze the structure of the set of positive solutions of a class of semilinear boundary value problems. It is shown that the global continuum of positive solutions emanating from the trivial equilibrium at the principal eigenvalue of the linearization is constituted by a regular curve if the slope of the kinetic at the trivial solution is large enough and Ω is convex. The same result holds if the support region of the species is a bounded simply connected domain of R2 close to a convex domain, in a sense to be precised later. To prove these results we have to find out the exact width of the boundary layer of a singular perturbation problem. The results about the singular perturbation problem are new and of great interest by themselves.

  3. Discourses of positionality and the challenges of democratization in the global south: The case of Nepal and Cameroon

    Directory of Open Access Journals (Sweden)

    Jacob Thorsen

    2012-03-01

    Full Text Available In this article, we argue that to conceptually and empirically grasp the dynamics and challenges of processes of civic participation, i.e., the deliberation and empowerment of disenfranchised and marginalized populations in the Global South, communication for social change scholars need to pay more attention to three issues: the quality of citizens’ self-perceptions in relation to their local milieu, inter-citizen perceptions and relations at the local level and lastly, the attendant consequences of these on citizens’ sense of efficacy. To grasp and comprehend the interplay of these three issues, we propose the adoption of Floya Anthias’ concept of narratives of location and positionality and demonstrate the heuristic vitality of this notion through a discussion of some local discourses of positionality in Nepal and Cameroon.

  4. The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes.

    Science.gov (United States)

    Sugden, Chris; Urbaniak, Michael D; Araki, Tsuyoshi; Williams, Jeffrey G

    2015-02-15

    Differentiation-inducing factor-1 (DIF-1) is a polyketide that induces Dictyostelium amoebae to differentiate as prestalk cells. We performed a global quantitative screen for phosphorylation changes that occur within the first minutes after addition of DIF-1, using a triple-label SILAC approach. This revealed a new world of DIF-1-controlled signaling, with changes in components of the MAPK and protein kinase B signaling pathways, components of the actinomyosin cytoskeletal signaling networks, and a broad range of small GTPases and their regulators. The results also provide evidence that the Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a role in DIF-1 signaling to the DimB prestalk transcription factor. At the global level, DIF-1 causes a major shift in the phosphorylation/dephosphorylation equilibrium toward net dephosphorylation. Of interest, many of the sites that are dephosphorylated in response to DIF-1 are phosphorylated in response to extracellular cAMP signaling. This accords with studies that suggest an antagonism between the two inducers and also with the rapid dephosphorylation of the cAMP receptor that we observe in response to DIF-1 and with the known inhibitory effect of DIF-1 on chemotaxis to cAMP. All MS data are available via ProteomeXchange with identifier PXD001555. © 2015 Sugden et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  5. Positioning in the Global Value Chain as a Sustainable Strategy: A Case Study in a Mature Industry

    Directory of Open Access Journals (Sweden)

    Jose Albors-Garrigos

    2014-06-01

    Full Text Available As a result of the development of new industrialized countries, such as Brazil, China and other Southern Asian economies, as well as a globalized economy, traditional competitive paradigms based on advantages associated with costs and quality efficiencies or even innovation are no longer sufficient. These previous classical paradigms related competitiveness either to costs or technology innovation and the resources of industry incumbents. However, the combination of adequate knowledge and relationship management with marketing efforts brings forth a reconsideration of the present competitive models that go beyond those analyses from the point of view of global value chains. The objective of this investigation will analyze the governance structure of the territorial value chain in the Spanish and Italian ceramic tile industry, through the understanding of the previous and current roles of several industries involved in the value creation system. By way of both a case study and quantitative methodology approach, we will explore the paradigm change where traditional chain actors are losing their grip on their contribution to the territorial value creation system as new actors appear with a more stable status. The article concludes that proper positioning in the global value chain is a key strategy for the sustainability of the involved firms, especially Small and Medium Enterprises (SME.

  6. New 3D parallel GILD electromagnetic modeling and nonlinear inversion using global magnetic integral and local differential equation

    Energy Technology Data Exchange (ETDEWEB)

    Xie, G.; Li, J.; Majer, E.; Zuo, D.

    1998-07-01

    This paper describes a new 3D parallel GILD electromagnetic (EM) modeling and nonlinear inversion algorithm. The algorithm consists of: (a) a new magnetic integral equation instead of the electric integral equation to solve the electromagnetic forward modeling and inverse problem; (b) a collocation finite element method for solving the magnetic integral and a Galerkin finite element method for the magnetic differential equations; (c) a nonlinear regularizing optimization method to make the inversion stable and of high resolution; and (d) a new parallel 3D modeling and inversion using a global integral and local differential domain decomposition technique (GILD). The new 3D nonlinear electromagnetic inversion has been tested with synthetic data and field data. The authors obtained very good imaging for the synthetic data and reasonable subsurface EM imaging for the field data. The parallel algorithm has high parallel efficiency over 90% and can be a parallel solver for elliptic, parabolic, and hyperbolic modeling and inversion. The parallel GILD algorithm can be extended to develop a high resolution and large scale seismic and hydrology modeling and inversion in the massively parallel computer.

  7. Return to play in elite rugby union: application of global positioning system technology in return-to-running programs.

    Science.gov (United States)

    Reid, Laura C; Cowman, Jason R; Green, Brian S; Coughlan, Garrett F

    2013-05-01

    Global positioning systems (GPS) are widely used in sport settings to evaluate the physical demands on players in training and competition. The use of these systems in the design and implementation of rehabilitation and return-to-running programs has not yet been elucidated. To demonstrate the application of GPS technology in the management of return to play in elite-club Rugby Union. Case series. Professional Rugby Union club team. 8 elite Rugby Union players (age 27.86 ± 4.78 y, height 1.85 ± 0.08 m, weight 99.14 ± 9.96 kg). Players wore GPS devices for the entire duration of a club game. Variables of locomotion speed and distance were measured. Differences in physical demands between playing positions were observed for all variables. An analysis of the position-specific physical demands measured by GPS provides key information regarding the level and volume of loads sustained by a player in a game environment. Using this information, sports-medicine practitioners can develop rehabilitation and return-to-running protocols specific to the player position to optimize safe return to play.

  8. Globalization

    DEFF Research Database (Denmark)

    Plum, Maja

    Globalization is often referred to as external to education - a state of affair facing the modern curriculum with numerous challenges. In this paper it is examined as internal to curriculum; analysed as a problematization in a Foucaultian sense. That is, as a complex of attentions, worries, ways...... of reasoning, producing curricular variables. The analysis is made through an example of early childhood curriculum in Danish Pre-school, and the way the curricular variable of the pre-school child comes into being through globalization as a problematization, carried forth by the comparative practices of PISA...

  9. Globalization

    OpenAIRE

    F. Gerard Adams

    2008-01-01

    The rapid globalization of the world economy is causing fundamental changes in patterns of trade and finance. Some economists have argued that globalization has arrived and that the world is “flat†. While the geographic scope of markets has increased, the author argues that new patterns of trade and finance are a result of the discrepancies between “old†countries and “new†. As the differences are gradually wiped out, particularly if knowledge and technology spread worldwide, the t...

  10. Global Transcriptome Analysis and Identification of Differentially Expressed Genes in Strawberry after Preharvest Application of Benzothiadiazole and Chitosan.

    Science.gov (United States)

    Landi, Lucia; De Miccolis Angelini, Rita M; Pollastro, Stefania; Feliziani, Erica; Faretra, Franco; Romanazzi, Gianfranco

    2017-01-01

    The use of resistance inducers is a novel strategy to elicit defense responses in strawberry fruit to protect against preharvest and postharvest decay. However, the mechanisms behind the specific resistance inducers are not completely understood. Here, global transcriptional changes in strawberry fruit were investigated using RNA-Seq technology. Preharvest, benzothiadiazole (BTH) and chitosan were applied to the plant canopy, and the fruit were harvested at 6, 12, and 24 h post-treatment. Overall, 5,062 and 5,210 differentially expressed genes (fold change ≥ 2) were identified in these fruits under the BTH and chitosan treatments, respectively, as compared to the control expression. About 80% of these genes were differentially expressed by both elicitors. Comprehensive functional enrichment analysis highlighted different gene modulation over time for transcripts associated with photosynthesis and heat-shock proteins, according to elicitor. Up-regulation of genes associated with reprogramming of protein metabolism was observed in fruit treated with both elicitors, which led to increased storage proteins. Several genes associated with the plant immune system, hormone metabolism, systemic acquired resistance, and biotic and abiotic stresses were differentially expressed in treated versus untreated plants. The RNA-Seq output was confirmed using RT-qPCR for 12 selected genes. This study demonstrates that these two elicitors affect cell networks associated with plant defenses in different ways, and suggests a role for chloroplasts as the primary target in this modulation of the plant defense responses, which actively communicate these signals through changes in redox status. The genes identified in this study represent markers to better elucidate plant/pathogen/resistance-inducer interactions, and to plan novel sustainable disease management strategies.

  11. Global transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Zhu Tong

    2007-08-01

    Full Text Available Abstract Background A large quantity of nitrogen (N fertilizer is used for crop production to achieve high yields at a significant economic and environmental cost. Efforts have been directed to understanding the molecular basis of plant responses to N and identifying N-responsive genes in order to manipulate their expression, thus enabling plants to use N more efficiently. No studies have yet delineated these responses at the transcriptional level when plants are grown under chronic N stress and the understanding of regulatory elements involved in N response is very limited. Results To further our understanding of the response of plants to varying N levels, a growth system was developed where N was the growth-limiting factor. An Arabidopsis whole genome microarray was used to evaluate global gene expression under different N conditions. Differentially expressed genes under mild or severe chronic N stress were identified. Mild N stress triggered only a small set of genes significantly different at the transcriptional level, which are largely involved in various stress responses. Plant responses were much more pronounced under severe N stress, involving a large number of genes in many different biological processes. Differentially expressed genes were also identified in response to short- and long-term N availability increases. Putative N regulatory elements were determined along with several previously known motifs involved in the responses to N and carbon availability as well as plant stress. Conclusion Differentially expressed genes identified provide additional insights into the coordination of the complex N responses of plants and the components of the N response mechanism. Putative N regulatory elements were identified to reveal possible new components of the regulatory network for plant N responses. A better understanding of the complex regulatory network for plant N responses will help lead to strategies to improve N use efficiency.

  12. Global warming alters sound transmission: differential impact on the prey detection ability of echolocating bats

    Science.gov (United States)

    Luo, Jinhong; Koselj, Klemen; Zsebők, Sándor; Siemers, Björn M.; Goerlitz, Holger R.

    2014-01-01

    Climate change impacts the biogeography and phenology of plants and animals, yet the underlying mechanisms are little known. Here, we present a functional link between rising temperature and the prey detection ability of echolocating bats. The maximum distance for echo-based prey detection is physically determined by sound attenuation. Attenuation is more pronounced for high-frequency sound, such as echolocation, and is a nonlinear function of both call frequency and ambient temperature. Hence, the prey detection ability, and thus possibly the foraging efficiency, of echolocating bats and susceptible to rising temperatures through climate change. Using present-day climate data and projected temperature rises, we modelled this effect for the entire range of bat call frequencies and climate zones around the globe. We show that depending on call frequency, the prey detection volume of bats will either decrease or increase: species calling above a crossover frequency will lose and species emitting lower frequencies will gain prey detection volume, with crossover frequency and magnitude depending on the local climatic conditions. Within local species assemblages, this may cause a change in community composition. Global warming can thus directly affect the prey detection ability of individual bats and indirectly their interspecific interactions with competitors and prey. PMID:24335559

  13. Global warming alters sound transmission: differential impact on the prey detection ability of echolocating bats.

    Science.gov (United States)

    Luo, Jinhong; Koselj, Klemen; Zsebok, Sándor; Siemers, Björn M; Goerlitz, Holger R

    2014-02-06

    Climate change impacts the biogeography and phenology of plants and animals, yet the underlying mechanisms are little known. Here, we present a functional link between rising temperature and the prey detection ability of echolocating bats. The maximum distance for echo-based prey detection is physically determined by sound attenuation. Attenuation is more pronounced for high-frequency sound, such as echolocation, and is a nonlinear function of both call frequency and ambient temperature. Hence, the prey detection ability, and thus possibly the foraging efficiency, of echolocating bats and susceptible to rising temperatures through climate change. Using present-day climate data and projected temperature rises, we modelled this effect for the entire range of bat call frequencies and climate zones around the globe. We show that depending on call frequency, the prey detection volume of bats will either decrease or increase: species calling above a crossover frequency will lose and species emitting lower frequencies will gain prey detection volume, with crossover frequency and magnitude depending on the local climatic conditions. Within local species assemblages, this may cause a change in community composition. Global warming can thus directly affect the prey detection ability of individual bats and indirectly their interspecific interactions with competitors and prey.

  14. Global Positioning System Technology (GPS for Psychological Research: A Test of Convergent and Nomological Validity

    Directory of Open Access Journals (Sweden)

    Pedro eWolf

    2013-06-01

    Full Text Available The purpose of this paper is to examine the convergent and nomological validity of a GPS-based measure of daily activity, operationalized as Number of Places Visited (NPV. Relations among the GPS-based measure and two self-report measures of NPV, as well as relations among NPV and two factors made up of self-reported individual differences were examined. The first factor was composed of variables related to an Active Lifestyle (AL (e.g. positive affect, extraversion… and the second factor was composed of variables related to a Sedentary Lifestyle (SL (e.g. depression, neuroticism…. NPV was measured over a four-day period. This timeframe was made up of two week and two weekend days. A bi-variate analysis established one level of convergent validity and a Split-Plot GLM examined convergent validity, nomological validity, and alternative hypotheses related to constraints on activity throughout the week simultaneously. The first analysis revealed significant correlations among NPV measures- weekday, weekend, and the entire four day blocks, supporting the convergent validity of the Diary-, Google Maps-, and GPS-NPV measures. Results from the second analysis, indicating non-significant mean differences in NPV regardless of method, also support this conclusion. We also found that AL is a statistically significant predictor of NPV no matter how NPV was measured. We did not find a statically significant relation among NPV and SL. These results permit us to infer that the GPS-based NPV measure has convergent and nomological validity.

  15. Using the global positioning system in support of environmental characterization at the Hanford Site in Washington State

    International Nuclear Information System (INIS)

    Peterson, L.B.; Tzemos, S.; Dietz, L.A.

    1993-10-01

    The US Department of Energy's 1,450 km 2 Hanford Site in southeastern Washington State accumulated hazardous wastes for more than 50 years. To support the Site's mission of environmental restoration and cleanup, the Global Positioning System (GPS) is being used to verify waste site locations and provide location information for field samples. Collected GPS data are stored for use in the Hanford Geographic Information System (HGIS). The NAVSTAR GPS is a space-based electronic navigation and positioning system designed and operated by the US Department of Defense (DOD). The system consists of three major components: (1) the space segment, comprising 24 earth-orbiting satellites; (2) the control segment, made up of 5 control and monitoring stations placed around the globe; and (3) the user segment, which includes users worldwide. When declared fully operational by the DOD, the NAVSTAR GPS will allow users to identify their geographical position anywhere on earth at any time. There are no user fees for the service and anyone with a GPS receiver may use the system worldwide. The one major hindrance to the system is the DOD policy concerning a security option called Selective Availability (SA). Selective Availability affects the usability of the system by intentional manipulation of the GPS signals to degrade the accuracy of the user's positions. The period and magnitude of degradation is solely a DOD privilege. The DOD policy on SA is to vary the error in position calculated from the Standard Positioning Service code to approximately 100 m root-mean squared (RMS). With SA on and other possible errors included, users may know their location to within a few hundred meters. While this accuracy is good for many applications, it is too inaccurate for others

  16. An adaptive differential evolution algorithm with novel mutation and crossover strategies for global numerical optimization.

    Science.gov (United States)

    Islam, Sk Minhazul; Das, Swagatam; Ghosh, Saurav; Roy, Subhrajit; Suganthan, Ponnuthurai Nagaratnam

    2012-04-01

    Differential evolution (DE) is one of the most powerful stochastic real parameter optimizers of current interest. In this paper, we propose a new mutation strategy, a fitness-induced parent selection scheme for the binomial crossover of DE, and a simple but effective scheme of adapting two of its most important control parameters with an objective of achieving improved performance. The new mutation operator, which we call DE/current-to-gr_best/1, is a variant of the classical DE/current-to-best/1 scheme. It uses the best of a group (whose size is q% of the population size) of randomly selected solutions from current generation to perturb the parent (target) vector, unlike DE/current-to-best/1 that always picks the best vector of the entire population to perturb the target vector. In our modified framework of recombination, a biased parent selection scheme has been incorporated by letting each mutant undergo the usual binomial crossover with one of the p top-ranked individuals from the current population and not with the target vector with the same index as used in all variants of DE. A DE variant obtained by integrating the proposed mutation, crossover, and parameter adaptation strategies with the classical DE framework (developed in 1995) is compared with two classical and four state-of-the-art adaptive DE variants over 25 standard numerical benchmarks taken from the IEEE Congress on Evolutionary Computation 2005 competition and special session on real parameter optimization. Our comparative study indicates that the proposed schemes improve the performance of DE by a large magnitude such that it becomes capable of enjoying statistical superiority over the state-of-the-art DE variants for a wide variety of test problems. Finally, we experimentally demonstrate that, if one or more of our proposed strategies are integrated with existing powerful DE variants such as jDE and JADE, their performances can also be enhanced.

  17. Differential MHC class II component expression in HPV-positive cervical cancer cells: implication for immune surveillance.

    Science.gov (United States)

    Zehbe, Ingeborg; Höhn, Hanni; Pilch, Henryk; Neukirch, Claudia; Freitag, Kirsten; Maeurer, Markus J

    2005-12-10

    Effective eradication of human papillomavirus (HPV)-positive tumors may require CD8+ and CD4+ T-cell-mediated immune responses. Ectopic expression of MHC class II surface molecules has been described in the context of cervical cancer, but coexpression with other components of the MHC class II antigen presentation pathway has not been addressed. We have evaluated the MHC class II antigen presentation pathway in malignant squamous epithelium of HPV+ cervical cancer lesions by in situ costaining HLA-DR with CLIP or DMA/DMB. Cervical cancer cells exhibit 3 MHC class II phenotypes: (i) DR+/CLIP+ or DM+; (ii) DR+/CLIP- or DM-; and (iii) DR-/CLIP+ or DM+. The identical profile has been identified in HPV+ ME180 cells, which serve as a target for HLA-DR4-restricted and HPV68, E7-specific CD4+ T cells. IFN-gamma pretreatment of ME180 cells, associated with differential trafficking of MHC class II molecules, is necessary for effective T-cell recognition. Although proinflammatory cytokines may facilitate MHC class II-restricted antigen recognition in tumor cells, different phenotypes of the MHC class II antigen presentation pathway may be associated with evasion from CD4+-mediated cellular immune responses. Copyright 2005 Wiley-Liss, Inc

  18. Differential time to positivity of central and peripheral blood cultures is inaccurate for the diagnosis of Staphylococcus aureus long-term catheter-related sepsis.

    Science.gov (United States)

    Bouzidi, H; Emirian, A; Marty, A; Chachaty, E; Laplanche, A; Gachot, B; Blot, F

    2018-02-10

    Differential time to positivity of cultures of blood drawn simultaneously from central venous catheter and peripheral sites is widely used to diagnose catheter-related bloodstream infections without removing the catheter. However, the accuracy of this technique for some pathogens, such as Staphylococcus aureus, is debated in routine practice. In a 320-bed reference cancer centre, the charts of patients with at least one blood culture positive for S. aureus among paired blood cultures drawn over a six-year period were studied retrospectively. Microbiological data were extracted from the prospectively compiled database of the microbiology unit. Data concerning the 149 patients included were reviewed retrospectively by independent physicians blinded to the absolute and differential times to positivity, in order to establish or refute the diagnosis of catheter-related sepsis. Due to missing data, 48 charts were excluded, so 101 cases were actually analysed. The diagnosis was established in 62 cases, refuted in 15 cases and inconclusive in the remaining 24 cases. For the 64 patients with both central and peripheral positive blood cultures, the differential positivity time was significantly greater for patients with catheter-related bloodstream infections due to S. aureus (Pcatheter-related bloodstream infection due to S. aureus. These results strongly suggest that despite its high specificity, the differential time to positivity may not be reliable to rule out catheter-related bloodstream infection due to S. aureus. Copyright © 2018. Published by Elsevier Ltd.

  19. Differential returns from globalization to women smallholder coffee and food producers in rural Uganda.

    Science.gov (United States)

    Kanyamurwa, J M; Wamala, S; Baryamutuma, R; Kabwama, E; Loewenson, R

    2013-09-01

    Globalization-related measures to liberalize trade and stimulate export production were applied in Uganda in the late 1980s, including in the coffee production sector, to revitalize agricultural production, increase incomes to farmers and improve rural food security. To explore the different effects of such measures on the health and dietary outcomes of female coffee and food small holder farmers in Uganda. We gathered evidence through a cross-sectional comparative interview survey of 190 female coffee producers and 191 female food producers in Ntungamo district. The study mostly employed quantitative methods of data collection, targeting the sampled households. We also utilized qualitative data; collected three months after the household survey data had been collected and their analysis had been accomplished. Using qualitative interviews based on an unstructured interview guide, extra qualitative information was collected from key informants at national, district and community levels. This was among other underlying principles to avoid relying on snapshot information earlier collected at household level in order to draw valid and compelling conclusions from the study. We used indicators of production, income, access to food and dietary patterns, women's health and health care. Of the two groups selected from the same area, female coffee producers represented a higher level of integration into liberalised export markets. Document review suggests that, although Uganda's economy grew in the period, the household economic and social gains after the liberalization measures may have been less than expected. In the survey carried out, both food and coffee producers were similarly poor, involved in small-scale production, and of a similar age and education level. Coffee producers had greater land and livestock ownership, greater access to inputs and higher levels of income and used a wider variety of markets than food producers, but they had to work longer hours to obtain

  20. Globalization

    DEFF Research Database (Denmark)

    Plum, Maja

    Globalization is often referred to as external to education - a state of affair facing the modern curriculum with numerous challenges. In this paper it is examined as internal to curriculum; analysed as a problematization in a Foucaultian sense. That is, as a complex of attentions, worries, ways...... of reasoning, producing curricular variables. The analysis is made through an example of early childhood curriculum in Danish Pre-school, and the way the curricular variable of the pre-school child comes into being through globalization as a problematization, carried forth by the comparative practices of PISA....... It thus explores the systems of reason that educational comparative practices carry through time; focusing on the way configurations are reproduced and transformed, forming the pre-school child as a central curricular variable....

  1. Exploring the potential of intersectoral partnerships to improve the position of farmers in global agrifood chains: findings from the coffee sector in Peru

    NARCIS (Netherlands)

    Bitzer, V.C.; Glasbergen, P.; Arts, B.

    2012-01-01

    Despite their recent proliferation in global agricultural commodity chains, little is known about the potential of intersectoral partnerships to improve the position of smallholder farmers and their organizations. This article explores the potential of partnerships by developing a conceptual

  2. Supine Versus Prone Position During Percutaneous Nephrolithotomy: A Report from the Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study

    DEFF Research Database (Denmark)

    G. Vadivia, José; M. Scarpa, Roberto; Duvdevani, Mordechai

    2011-01-01

    To determine differences in patients' characteristics, operative time and procedures, and perioperative outcomes between prone and supine positioning in percutaneous nephrolithotomy (PCNL) using the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study database....

  3. Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies.

    Directory of Open Access Journals (Sweden)

    Rui Wei

    Full Text Available Human embryonic stem cells (hESCs are pluripotent and capable of undergoing multilineage differentiation into highly specialized cells including pancreatic islet cells. Thus, they represent a novel alternative source for targeted therapies and regenerative medicine for diabetes. Significant progress has been made in differentiating hESCs toward pancreatic lineages. One approach is based on the similarities of pancreatic β cell and neuroepithelial development. Nestin-positive cells are selected as pancreatic β cell precursors and further differentiated to secrete insulin. The other approach is based on our knowledge of developmental biology in which the differentiation protocol sequentially reproduces the individual steps that are known in normal β cell ontogenesis during fetal pancreatic development. In the present study, the hESC cell line PKU1.1 was induced to differentiate into insulin-producing cells (IPCs using both protocols. The differentiation process was dynamically investigated and the similarities and differences between both strategies were explored. Our results show that IPCs can be successfully induced with both differentiation strategies. The resulting IPCs from both protocols shared many similar features with pancreatic islet cells, but not mature, functional β cells. However, these differently-derived IPC cell types displayed specific morphologies and different expression levels of pancreatic islet development-related markers. These data not only broaden our outlook on hESC differentiation into IPCs, but also extend the full potential of these processes for regenerative medicine in diabetes.

  4. A pilot study using global positioning systems (GPS) devices and surveys to ascertain older adults' travel patterns.

    Science.gov (United States)

    Yen, Irene H; Leung, Cindy W; Lan, Mars; Sarrafzadeh, Majid; Kayekjian, Karen C; Duru, O Kenrik

    2015-04-01

    Some studies indicate that older adults lead active lives and travel to many destinations including those not in their immediate residential neighborhoods. We used global positioning system (GPS) devices to track the travel patterns of 40 older adults (mean age: 69) in San Francisco and Los Angeles. Study participants wore the GPS devices for 7 days in fall 2010 and winter 2011. We collected survey responses concurrently about travel patterns. GPS data showed a mean of four trips/day, and a mean trip distance of 7.6 km. Survey data indicated that older adults commonly made trips for four activities (e.g., volunteering, work, visiting friends) at least once each week. Older adults regularly travel outside their residential neighborhoods. GPS can document the mode of travel, the path of travel, and the destinations. Surveys can document the purpose of the travel and the impressions or experiences in the specific locations. © The Author(s) 2013.

  5. Design and implementation of geographic information systems, remote sensing, and global positioning system-based information platform for locust control

    Science.gov (United States)

    Li, Lin; Zhu, Dehai; Ye, Sijing; Yao, Xiaochuang; Li, Jun; Zhang, Nan; Han, Yueqi; Zhang, Long

    2014-01-01

    To monitor and control locusts efficiently, an information platform for locust control based on the global positioning system (GPS), remote sensing (RS), and geographic information systems (GIS) was developed. The platform can provide accurate information about locust occurrence and control strategies for a specific geographic place. The platform consists of three systems based on modern pest control: field ecology (locust occurrence) and GIS in a mobile GPS pad, a processing system for locust information based on GIS and RS, and a WebGIS-based real-time monitoring and controlling system. This platform was run at different geographical locations for three years and facilitated locust control in China with high efficiency and great accuracy.

  6. Inequalities in Global Trade: A Cross-Country Comparison of Trade Network Position, Economic Wealth, Pollution and Mortality.

    Science.gov (United States)

    Prell, Christina; Sun, Laixiang; Feng, Kuishuang; Myroniuk, Tyler W

    2015-01-01

    In this paper we investigate how structural patterns of international trade give rise to emissions inequalities across countries, and how such inequality in turn impact countries' mortality rates. We employ Multi-regional Input-Output analysis to distinguish between sulfur-dioxide (SO2) emissions produced within a country's boarders (production-based emissions) and emissions triggered by consumption in other countries (consumption-based emissions). We use social network analysis to capture countries' level of integration within the global trade network. We then apply the Prais-Winsten panel estimation technique to a panel data set across 172 countries over 20 years (1990-2010) to estimate the relationships between countries' level of integration and SO2 emissions, and the impact of trade integration and SO2 emission on mortality rates. Our findings suggest a positive, (log-) linear relationship between a country's level of integration and both kinds of emissions. In addition, although more integrated countries are mainly responsible for both forms of emissions, our findings indicate that they also tend to experience lower mortality rates. Our approach offers a unique combination of social network analysis with multiregional input-output analysis, which better operationalizes intuitive concepts about global trade and trade structure.

  7. Regaining America's leading global position in the innovation of science and technology: Increasing engineering program enrollment in higher education

    Science.gov (United States)

    Burklo, Daniel A.

    While the United States has always been a global leader in the innovation of science and technology, this leading global position is in jeopardy. As other developing countries produce intellectual capital in the form of engineers at increasing rates, the country will continue to lose ground. Today the need for the country to produce engineers is greater than ever before. Recognizing this need, attempts have been made to increase entrance into engineering fields in higher education by providing STEM (science, technology, engineering, and mathematics) activities during K-12 education. While STEM initiatives create awareness and interest, this study investigates what actually motivates individuals to choose engineering programs in higher education. A quantitative study utilizing survey results from 202 first year engineering students in the state of Ohio illustrates what has motivated them to choose engineering as a major. The study examines who, when, and what motivated the students to choose engineering by examining the relationship of influential people and STEM initiatives participated in during their K-12 education to enrollment in engineering programs at colleges and universities in the state of Ohio. The study proved the general hypothesis that there are influential people in an individual's college choice, such as the parent, and there are time periods during K-12 education when individuals are more motivated, such as the high school years. The study also showed a positive correlation between the motivation toward engineering programs and the number of STEM opportunities in which individuals participated yet there was little difference when comparing the different types of STEM initiatives.

  8. Global gene expression shift during the transition from early neural development to late neuronal differentiation in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Rafael Cantera

    Full Text Available Regulation of transcription is one of the mechanisms involved in animal development, directing changes in patterning and cell fate specification. Large temporal data series, based on microarrays across the life cycle of the fly Drosophila melanogaster, revealed the existence of groups of genes which expression increases or decreases temporally correlated during the life cycle. These groups of genes are enriched in different biological functions. Here, instead of searching for temporal coincidence in gene expression using the entire genome expression data, we searched for temporal coincidence in gene expression only within predefined catalogues of functionally related genes and investigated whether a catalogue's expression profile can be used to generate larger catalogues, enriched in genes necessary for the same function. We analyzed the expression profiles from genes already associated with early neurodevelopment and late neurodifferentiation, at embryonic stages 16 and 17 of Drosophila life cycle. We hypothesized that during this interval we would find global downregulation of genes important for early neuronal development together with global upregulation of genes necessary for the final differentiation of neurons. Our results were consistent with this hypothesis. We then investigated if the expression profile of gene catalogues representing particular processes of neural development matched the temporal sequence along which these processes occur. The profiles of genes involved in patterning, neurogenesis, axogenesis or synaptic transmission matched the prediction, with largest transcript values at the time when the corresponding biological process takes place in the embryo. Furthermore, we obtained catalogues enriched in genes involved in temporally matching functions by performing a genome-wide systematic search for genes with their highest expression levels at the corresponding embryonic intervals. These findings imply the use of gene

  9. Existence and properties of semi-bounded global solutions to the functional differential equation with Volterra-type operators on the real line

    Czech Academy of Sciences Publication Activity Database

    Hakl, Robert; Aguerrea, M.

    2017-01-01

    Roč. 147, č. 6 (2017), s. 1119-1168 ISSN 0308-2105 Institutional support: RVO:67985840 Keywords : functional differential equations * boundary-value problems * global existence Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics Impact factor: 1.158, year: 2016

  10. Existence and properties of semi-bounded global solutions to the functional differential equation with Volterra-type operators on the real line

    Czech Academy of Sciences Publication Activity Database

    Hakl, Robert; Aguerrea, M.

    2017-01-01

    Roč. 147, č. 6 (2017), s. 1119-1168 ISSN 0308-2105 Institutional support: RVO:67985840 Keywords : functional differential equations * boundary-value problems * global existence Subject RIV: BA - General Mathematics Impact factor: 1.158, year: 2016

  11. Fast Measurement and Reconstruction of Large Workpieces with Freeform Surfaces by Combining Local Scanning and Global Position Data

    Directory of Open Access Journals (Sweden)

    Zhe Chen

    2015-06-01

    Full Text Available In this paper, we propose a new approach for the measurement and reconstruction of large workpieces with freeform surfaces. The system consists of a handheld laser scanning sensor and a position sensor. The laser scanning sensor is used to acquire the surface and geometry information, and the position sensor is utilized to unify the scanning sensors into a global coordinate system. The measurement process includes data collection, multi-sensor data fusion and surface reconstruction. With the multi-sensor data fusion, errors accumulated during the image alignment and registration process are minimized, and the measuring precision is significantly improved. After the dense accurate acquisition of the three-dimensional (3-D coordinates, the surface is reconstructed using a commercial software piece, based on the Non-Uniform Rational B-Splines (NURBS surface. The system has been evaluated, both qualitatively and quantitatively, using reference measurements provided by a commercial laser scanning sensor. The method has been applied for the reconstruction of a large gear rim and the accuracy is up to 0.0963 mm. The results prove that this new combined method is promising for measuring and reconstructing the large-scale objects with complex surface geometry. Compared with reported methods of large-scale shape measurement, it owns high freedom in motion, high precision and high measurement speed in a wide measurement range.

  12. Adaptive Correlation Space Adjusted Open-Loop Tracking Approach for Vehicle Positioning with Global Navigation Satellite System in Urban Areas.

    Science.gov (United States)

    Ruan, Hang; Li, Jian; Zhang, Lei; Long, Teng

    2015-08-28

    For vehicle positioning with Global Navigation Satellite System (GNSS) in urban areas, open-loop tracking shows better performance because of its high sensitivity and superior robustness against multipath. However, no previous study has focused on the effects of the code search grid size on the code phase measurement accuracy of open-loop tracking. Traditional open-loop tracking methods are performed by the batch correlators with fixed correlation space. The code search grid size, which is the correlation space, is a constant empirical value and the code phase measuring accuracy will be largely degraded due to the improper grid size, especially when the signal carrier-to-noise density ratio (C/N₀) varies. In this study, the Adaptive Correlation Space Adjusted Open-Loop Tracking Approach (ACSA-OLTA) is proposed to improve the code phase measurement dependent pseudo range accuracy. In ACSA-OLTA, the correlation space is adjusted according to the signal C/N₀. The novel Equivalent Weighted Pseudo Range Error (EWPRE) is raised to obtain the optimal code search grid sizes for different C/N₀. The code phase measuring errors of different measurement calculation methods are analyzed for the first time. The measurement calculation strategy of ACSA-OLTA is derived from the analysis to further improve the accuracy but reduce the correlator consumption. Performance simulation and real tests confirm that the pseudo range and positioning accuracy of ASCA-OLTA are better than the traditional open-loop tracking methods in the usual scenarios of urban area.

  13. Kullback-Leibler Divergence-Based Differential Evolution Markov Chain Filter for Global Localization of Mobile Robots.

    Science.gov (United States)

    Martín, Fernando; Moreno, Luis; Garrido, Santiago; Blanco, Dolores

    2015-09-16

    One of the most important skills desired for a mobile robot is the ability to obtain its own location even in challenging environments. The information provided by the sensing system is used here to solve the global localization problem. In our previous work, we designed different algorithms founded on evolutionary strategies in order to solve the aforementioned task. The latest developments are presented in this paper. The engine of the localization module is a combination of the Markov chain Monte Carlo sampling technique and the Differential Evolution method, which results in a particle filter based on the minimization of a fitness function. The robot's pose is estimated from a set of possible locations weighted by a cost value. The measurements of the perceptive sensors are used together with the predicted ones in a known map to define a cost function to optimize. Although most localization methods rely on quadratic fitness functions, the sensed information is processed asymmetrically in this filter. The Kullback-Leibler divergence is the basis of a cost function that makes it possible to deal with different types of occlusions. The algorithm performance has been checked in a real map. The results are excellent in environments with dynamic and unmodeled obstacles, a fact that causes occlusions in the sensing area.

  14. Kullback-Leibler Divergence-Based Differential Evolution Markov Chain Filter for Global Localization of Mobile Robots

    Directory of Open Access Journals (Sweden)

    Fernando Martín

    2015-09-01

    Full Text Available One of the most important skills desired for a mobile robot is the ability to obtain its own location even in challenging environments. The information provided by the sensing system is used here to solve the global localization problem. In our previous work, we designed different algorithms founded on evolutionary strategies in order to solve the aforementioned task. The latest developments are presented in this paper. The engine of the localization module is a combination of the Markov chain Monte Carlo sampling technique and the Differential Evolution method, which results in a particle filter based on the minimization of a fitness function. The robot’s pose is estimated from a set of possible locations weighted by a cost value. The measurements of the perceptive sensors are used together with the predicted ones in a known map to define a cost function to optimize. Although most localization methods rely on quadratic fitness functions, the sensed information is processed asymmetrically in this filter. The Kullback-Leibler divergence is the basis of a cost function that makes it possible to deal with different types of occlusions. The algorithm performance has been checked in a real map. The results are excellent in environments with dynamic and unmodeled obstacles, a fact that causes occlusions in the sensing area.

  15. Improve wildlife species tracking—Implementing an enhanced global positioning system data management system for California condors

    Science.gov (United States)

    Waltermire, Robert G.; Emmerich, Christopher U.; Mendenhall, Laura C.; Bohrer, Gil; Weinzierl, Rolf P.; McGann, Andrew J.; Lineback, Pat K.; Kern, Tim J.; Douglas, David C.

    2016-05-03

    U.S. Fish and Wildlife Service (USFWS) staff in the Pacific Southwest Region and at the Hopper Mountain National Wildlife Refuge Complex requested technical assistance to improve their global positioning system (GPS) data acquisition, management, and archive in support of the California Condor Recovery Program. The USFWS deployed and maintained GPS units on individual Gymnogyps californianus (California condor) in support of long-term research and daily operational monitoring and management of California condors. The U.S. Geological Survey (USGS) obtained funding through the Science Support Program to provide coordination among project participants, provide GPS Global System for Mobile Communication (GSM) transmitters for testing, and compare GSM/GPS with existing Argos satellite GPS technology. The USFWS staff worked with private companies to design, develop, and fit condors with GSM/GPS transmitters. The Movebank organization, an online database of animal tracking data, coordinated with each of these companies to automatically stream their GPS data into Movebank servers and coordinated with USFWS to improve Movebank software for managing transmitter data, including proofing/error checking of incoming GPS data. The USGS arranged to pull raw GPS data from Movebank into the USGS California Condor Management and Analysis Portal (CCMAP) (https://my.usgs.gov/ccmap) for production and dissemination of a daily map of condor movements including various automated alerts. Further, the USGS developed an automatic archiving system for pulling raw and proofed Movebank data into USGS ScienceBase to comply with the Federal Information Security Management Act of 2002. This improved data management system requires minimal manual intervention resulting in more efficient data flow from GPS data capture to archive status. As a result of the project’s success, Pinnacles National Park and the Ventana Wildlife Society California condor programs became partners and adopted the same

  16. Thermal Band Atmospheric Correction Using Atmospheric Profiles Derived from Global Positioning System Radio Occultation and the Atmospheric Infrared Sounder

    Science.gov (United States)

    Pagnutti, Mary; Holekamp, Kara; Stewart, Randy; Vaughan, Ronald D.

    2006-01-01

    This Rapid Prototyping Capability study explores the potential to use atmospheric profiles derived from GPS (Global Positioning System) radio occultation measurements and by AIRS (Atmospheric Infrared Sounder) onboard the Aqua satellite to improve surface temperature retrieval from remotely sensed thermal imagery. This study demonstrates an example of a cross-cutting decision support technology whereby NASA data or models are shown to improve a wide number of observation systems or models. The ability to use one data source to improve others will be critical to the GEOSS (Global Earth Observation System of Systems) where a large number of potentially useful systems will require auxiliary datasets as input for decision support. Atmospheric correction of thermal imagery decouples TOA radiance and separates surface emission from atmospheric emission and absorption. Surface temperature can then be estimated from the surface emission with knowledge of its emissivity. Traditionally, radiosonde sounders or atmospheric models based on radiosonde sounders, such as the NOAA (National Oceanic & Atmospheric Administration) ARL (Air Resources Laboratory) READY (Real-time Environmental Application and Display sYstem), provide the atmospheric profiles required to perform atmospheric correction. Unfortunately, these types of data are too spatially sparse and too infrequently taken. The advent of high accuracy, global coverage, atmospheric data using GPS radio occultation and AIRS may provide a new avenue for filling data input gaps. In this study, AIRS and GPS radio occultation derived atmospheric profiles from the German Aerospace Center CHAMP (CHAllenging Minisatellite Payload), the Argentinean Commission on Space Activities SAC-C (Satellite de Aplicaciones Cientificas-C), and the pair of NASA GRACE (Gravity Recovery and Climate Experiment) satellites are used as input data in atmospheric radiative transport modeling based on the MODTRAN (MODerate resolution atmospheric

  17. TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.

    Directory of Open Access Journals (Sweden)

    Daniel Édgar Cortés

    2016-09-01

    Full Text Available Embryonic stem cells (ESC are pluripotent and thus can differentiate into every cell type present in the body. Directed differentiation into motor neurons has been described for pluripotent cells. Although neurotrophic factors promote neuronal survival, their role in neuronal commitment is elusive. Here, we developed double-transgenic lines of mouse ESC that constitutively produce Glial cell-derived neurotrophic factor (GDNF and also contain a GFP reporter, driven by HB9, which is expressed only by postmitotic motor neurons. After lentiviral transduction, ESC lines integrated and expressed the human GDNF gene without altering pluripotency markers before differentiation. Further, GDNF-ESC showed significantly higher spontaneous release of this neurotrophin to the medium, when compared to controls. To study motor neuron induction, control and GDNF cell lines were grown as embryoid bodies and stimulated with retinoic acid and Sonic Hedgehog. In GDNF-overexpressing cells, a significant increase of proliferative Olig2+ precursors, which are specified as spinal motor neurons, was found. Accordingly, GDNF increases the yield of cells with the pan motor neuronal markers HB9, monitored by GFP expression, and Isl1. At terminal differentiation, almost all differentiated neurons express phenotypic markers of motor neurons in GDNF cultures, with lower proportions in control cells. To test if the effects of GDNF were present at early differentiation stages, exogenous recombinant human GDNF was added to control ESC, also resulting in enhanced motor neuron differentiation. This effect was abolished by the co-addition of neutralizing anti-GDNF antibodies, strongly suggesting that differentiating ESC are responsive to GDNF. Using the HB9::GFP reporter, motor neurons were selected for electrophysiological recordings. Motor neurons differentiated from GDNF-ESC, compared to control motor neurons, showed greater electrophysiological maturation, characterized by

  18. A new tool to monitor training and performance of sport horses using global positioning system (GPS) with integrated GSM capabilities.

    Science.gov (United States)

    Hebenbrock, M; Düe, M; Holzhausen, H; Sass, A; Stadler, P; Ellendorff, F

    2005-07-01

    Global Positioning Systems (GPS) are considered suitable to monitor the position and velocity of horses during cross-country competition or in training. Furthermore, simultaneous recording of life data such as heart rate could be useful to assess the horse's condition during exercise. To test the suitability and reliability of a commercially available GPS system with integrated heart rate recording system and with built in GSM for data transmission, the Fidelak Equipilot Type EP-2003-15/G-2.11 (EP-15/G) was evaluated first for reliability of pulse recording from a pulse generator within the physiological range of horses; furthermore distance, velocity and heart rate recordings were carried out on a standard 1000 m field track with five repetitions. Agreement (% deviation from actually measured distance and from stopwatch-distance based velocity calculations) and variability (Coefficient of Variation for distance, velocity, heart rate) were calculated. From the results it was safe to assume that the heart rate sensor recorded horse heart rates at a high degree of accuracy. Overall distances and velocities are in high agreement with actually measured values. However, overall variability expressed in terms of relative variability (C.V.) is smaller for distance recording (C.V. 0.68%) when compared to velocity (C.V. 1.01%). The system tested is suitable and reliable for simultaneously recording of distance, velocity and heart rates for horses during cross country exercise. GPS-based monitoring of movement along with simultaneous recording of physiological data and the possibility to call upon data will not only be of benefit for training horses or for surveillance during competition, it may also be suitable for distant patient monitoring and in behavioural studies as well as in veterinary medicine in general.

  19. Performances of different global positioning system devices for time-location tracking in air pollution epidemiological studies.

    Science.gov (United States)

    Wu, Jun; Jiang, Chengsheng; Liu, Zhen; Houston, Douglas; Jaimes, Guillermo; McConnell, Rob

    2010-11-23

    People's time-location patterns are important in air pollution exposure assessment because pollution levels may vary considerably by location. A growing number of studies are using global positioning systems (GPS) to track people's time-location patterns. Many portable GPS units that archive location are commercially available at a cost that makes their use feasible for epidemiological studies. We evaluated the performance of five portable GPS data loggers and two GPS cell phones by examining positional accuracy in typical locations (indoor, outdoor, in-vehicle) and factors that influence satellite reception (building material, building type), acquisition time (cold and warm start), battery life, and adequacy of memory for data storage. We examined stationary locations (eg, indoor, outdoor) and mobile environments (eg, walking, traveling by vehicle or bus) and compared GPS locations to highly-resolved US Geological Survey (USGS) and Digital Orthophoto Quarter Quadrangle (DOQQ) maps. The battery life of our tested instruments ranged from 20 minutes and varied significantly by building structure type and by cold or warm start. No GPS device was found to have consistently superior performance with regard to spatial accuracy and signal loss. At fixed outdoor locations, 65%-95% of GPS points fell within 20-m of the corresponding DOQQ locations for all the devices. At fixed indoor locations, 50%-80% of GPS points fell within 20-m of the corresponding DOQQ locations for all the devices except one. Most of the GPS devices performed well during commuting on a freeway, with >80% of points within 10-m of the DOQQ route, but the performance was significantly impacted by surrounding structures on surface streets in highly urbanized areas. All the tested GPS devices had limitations, but we identified several devices which showed promising performance for tracking subjects' time location patterns in epidemiological studies.

  20. Identifying breast cancer risk loci by global differential allele-specific expression (DASE analysis in mammary epithelial transcriptome

    Directory of Open Access Journals (Sweden)

    Gao Chuan

    2012-10-01

    Full Text Available Abstract Background The significant mortality associated with breast cancer (BCa suggests a need to improve current research strategies to identify new genes that predispose women to breast cancer. Differential allele-specific expression (DASE has been shown to contribute to phenotypic variables in humans and recently to the pathogenesis of cancer. We previously reported that nonsense-mediated mRNA decay (NMD could lead to DASE of BRCA1/2, which is associated with elevated susceptibility to breast cancer. In addition to truncation mutations, multiple genetic and epigenetic factors can contribute to DASE, and we propose that DASE is a functional index for cis-acting regulatory variants and pathogenic mutations, and that global analysis of DASE in breast cancer precursor tissues can be used to identify novel causative alleles for breast cancer susceptibility. Results To test our hypothesis, we employed the Illumina® Omni1-Quad BeadChip in paired genomic DNA (gDNA and double-stranded cDNA (ds-cDNA samples prepared from eight BCa patient-derived normal mammary epithelial lines (HMEC. We filtered original array data according to heterozygous genotype calls and calculated DASE values using the Log ratio of cDNA allele intensity, which was normalized to the corresponding gDNA. We developed two statistical methods, SNP- and gene-based approaches, which allowed us to identify a list of 60 candidate DASE loci (DASE ≥ 2.00, P ≤ 0.01, FDR ≤ 0.05 by both methods. Ingenuity Pathway Analysis of DASE loci revealed one major breast cancer-relevant interaction network, which includes two known cancer causative genes, ZNF331 (DASE = 2.31, P = 0.0018, FDR = 0.040 and USP6 (DASE = 4.80, P = 0.0013, FDR = 0.013, and a breast cancer causative gene, DMBT1 (DASE=2.03, P = 0.0017, FDR = 0.014. Sequence analysis of a 5′ RACE product of DMBT1 demonstrated that rs2981745, a putative breast cancer risk locus, appears to be one of the causal variants leading to DASE

  1. Core Genome Multilocus Sequence Typing for Identification of Globally Distributed Clonal Groups and Differentiation of Outbreak Strains of Listeria monocytogenes.

    Science.gov (United States)

    Chen, Yi; Gonzalez-Escalona, Narjol; Hammack, Thomas S; Allard, Marc W; Strain, Errol A; Brown, Eric W

    2016-10-15

    schemes can be used for the simultaneous identification of clonal groups and the differentiation of individual outbreak strains and epidemiologically unrelated strains of the same clonal group. We further developed lineage-specific cgMLST schemes that targeted more genomic regions than the species-specific cgMLST schemes. Our data revealed the genome-level diversity of clonal groups defined by classic MLST schemes. Our identification of U.S. and international outbreaks caused by major clonal groups can contribute to further understanding of the global epidemiology of L. monocytogenes. Copyright © 2016 Chen et al.

  2. Comparison of mapped and measured total ionospheric electron content using global positioning system and beacon satellite observations

    International Nuclear Information System (INIS)

    Lanyi, G.E.; Roth, T.

    1988-01-01

    Total ionospheric electron contents (TEC) were measured by global positioning system (GPS) dual-frequency receivers developed by the Jet Propulsion Laboratory. The measurements included P-code (precise ranging code) and carrier phase data for six GPS satellites during multiple five-hour observing sessions. A set of these GPS TEC measurements were mapped from the GPS lines of sight to the line of sight of a Faraday beacon satellite by statistically fitting the TEC data to a simple model of the ionosphere. The mapped GPS TEC values were compared with the Faraday rotation measurements. Because GPS transmitter offsets are different for each satellite and because some GPS receiver offsets were uncalibrated, the sums of the satellite and receiver offsets were estimated simultaneously with the TEC in a least squares procedure. The accuracy of this estimation procedure is evaluated indicating that the error of the GPS-determined line of sight TEC can be at or below 1 x 10 to the 16th el/sq cm. Consequently, the current level of accuracy is comparable to the Faraday rotation technique; however, GPS provides superior sky coverage. 15 references

  3. CytR Is a Global Positive Regulator of Competence, Type VI Secretion, and Chitinases in Vibrio cholerae

    Science.gov (United States)

    Hammer, Brian K.

    2015-01-01

    The facultative pathogen Vibrio cholerae transitions between its human host and aquatic reservoirs where it colonizes chitinous surfaces. Growth on chitin induces expression of chitin utilization genes, genes involved in DNA uptake by natural transformation, and a type VI secretion system that allows contact-dependent killing of neighboring bacteria. We have previously shown that the transcription factor CytR, thought to primarily regulate the pyrimidine nucleoside scavenging response, is required for natural competence in V. cholerae. Through high-throughput RNA sequencing (RNA-seq), we show that CytR positively regulates the majority of competence genes, the three type VI secretion operons, and the four known or predicted chitinases. We used transcriptional reporters and phenotypic analysis to determine the individual contributions of quorum sensing, which is controlled by the transcription factors HapR and QstR; chitin utilization that is mediated by TfoX; and pyrimidine starvation that is orchestrated by CytR, toward each of these processes. We find that in V. cholerae, CytR is a global regulator of multiple behaviors affecting fitness and adaptability in the environment. PMID:26401962

  4. Analysis of Radiosonde Daily Bias by Comparing Precipitable Water Vapor Obtained from Global Positioning System and Radiosonde

    Directory of Open Access Journals (Sweden)

    Chang-Geun Park

    2010-12-01

    Full Text Available In this study, we compared the precipitable water vapor (PWV data derived from the radiosonde observation data at Sokcho Observatory and the PWV data at Sokcho Global Positioning System (GPS Observatory provided by Korea Astronomy and Space Science Institute, from 0000 UTC, June 1, 2007 to 1200 UTC, May 31, 2009, and analyzed the radiosonde bias between the day and the night. In the scatter diagram of the daytime and nighttime radiosonde PWV data and the GPS PWV data, dry bias was found in the daytime radiosonde observation as known in the previous study. In addition, for all the rainfall events, the tendency that the wet bias of the radiosonde PWV increased as the GPS PWV decreased and the dry bias of the radiosonde PWV increased as the GPS PWV increased was significantly less distinctive in nighttime than in daytime. The quantitative analysis of the bias and error of the radiosonde PWV data showed that the mean bias decreased in the second year, regardless of nighttime or daytime rainfall, and the non-rainfall root mean square error (RMSE was similar to that of the previous studies, while the rainfall RMSE was larger to a certain extent.

  5. Classification of indoor-outdoor location using combined global positioning system (GPS) and temperature data for personal exposure assessment.

    Science.gov (United States)

    Lee, B; Lim, C; Lee, K

    2017-04-04

    The objectives of this study was to determine the accuracy of indoor-outdoor classification based on GPS and temperature data in three different seasons. In the present study, a global positioning system (GPS) was used alongside temperature data collected in the field by a technician who visited 53 different indoor locations during summer, autumn and winter. The indoor-outdoor location was determined by GPS data alone, and in combination with temperature data. Determination of location by the GPS signal alone, based on the loss of GPS signal and using the used number of satellites (NSAT) signal factor, simple percentage agreements of 73.6 ± 2.9%, 72.9 ± 3.4%, and 72.1 ± 3.1% were obtained for summer, autumn, and winter, respectively. However, when temperature and GPS data were combined, simple percentage agreements were significantly improved (87.9 ± 3.3%, 84.1 ± 2.8%, and 86.3 ± 3.1%, respectively). A temperature criterion for indoor-outdoor determination of ~ Δ 2°C for 2 min could be applied during all three seasons. The results showed that combining GPS and temperature data improved the accuracy of indoor-outdoor determination.

  6. Position-independent geometric error identification and global sensitivity analysis for the rotary axes of five-axis machine tools

    Science.gov (United States)

    Guo, Shijie; Jiang, Gedong; Zhang, Dongsheng; Mei, Xuesong

    2017-04-01

    Position-independent geometric errors (PIGEs) are the fundamental errors of a five-axis machine tool. In this paper, to identify ten PIGEs peculiar to the rotary axes of five-axis machine tools with a tilting head, the mathematic model of the ten PIGEs is deduced and four measuring patterns are proposed. The measuring patterns and identifying method are validated on a five-axis machine tool with a tilting head, and the ten PIGEs of the machine tool are obtained. The sensitivities of the four adjustable PIGEs of the machine tool in different measuring patterns are analyzed by the Morris global sensitivity analysis method and the modifying method, and the procedure of the four adjustable PIGEs of the machine tool is given accordingly. Experimental results show that after and before modifying the four adjustable PIGEs, the average compensate rate reached 52.7%. It is proved that the proposed measuring, identifying, analyzing and modifying method are effective for error measurement and precision improvement of the five-axis machine tool.

  7. Application of the global positioning system to crustal deformation measurements: 3. Result from the southern California borderlands

    Science.gov (United States)

    Larson, Kristine M.

    1993-12-01

    Five years of measurements from the Global Positioning System (GPS) satellites collected between 1986 and 1991 are used to investigate deformation in the offshore regions of southern California. GPS provides the first practical technique to make precise geodetic measurements in the region. The geodetic network is situated along the California coastline from Vandenberg (120.6°W, 34.6°N) to San Diego, with additional sites on Santa Cruz, San Nicolas, Santa Catalina, Santa Rosa, and San Clemente Islands. The precision of horizontal interstation vectors is subcentimeter, and the interstation vector rate between OVRO and Vandenberg agrees with the very long baseline interferometry derived rate to within one standard deviation. No significant motion is observed in the western Santa Barbara Channel between Vandenberg and Santa Rosa Island, 0.5 ± 1.6 mm/yr, where the quoted uncertainties are one standard deviation. Motions in the eastern Santa Barbara Channel are consistent with compressional deformation of 6 ± 1 mm/yr at N16 ± 3°E. This motion is in agreement with seismicity and an independent geodetic analysis for the period 1971-1987 (Larsen, 1991). San Clemente Island is moving relative to San Diego at the rate of 5.9 ± 1.8 mm/yr at a direction of N38 ± 20°W. The motion between San Nicolas Island and San Clemente Island, 0.8 ± 1.5 mm/yr, is insignificant.

  8. Physical game demands in elite rugby union: a global positioning system analysis and possible implications for rehabilitation.

    Science.gov (United States)

    Coughlan, Garrett F; Green, Brian S; Pook, Paul T; Toolan, Eoin; O'Connor, Sean P

    2011-08-01

    Descriptive. To evaluate the physical demands of an international Rugby Union-level game using a global positioning system (GPS). Elite Rugby Union teams currently employ the latest technology to monitor and evaluate physical demands of training and games on their players. GPS data from 2 players, a back and a forward, were collected during an international Rugby Union game. Locomotion speed, total body load, and body load sustained in tackles and scrums were analyzed. Players completed an average distance of 6715 m and spent the major portion of the game standing or walking, interspersed with medium- and high-intensity running activities. The back performed a higher number of high-intensity sprints and reached a greater maximal speed. Body load data revealed that high levels of gravitational force are sustained in tackling and scrum tasks. The current study provides a detailed GPS analysis of the physical demands of international Rugby Union players. These data, when combined with game video footage, may assist sports medicine professionals in understanding the demands of the game and mechanism of injury, as well as improving injury rehabilitation.

  9. The validity and reliability of 5-Hz global positioning system units to measure team sport movement demands.

    Science.gov (United States)

    Johnston, Richard J; Watsford, Mark L; Pine, Matthew J; Spurrs, Robert W; Murphy, Aron J; Pruyn, Elizabeth C

    2012-03-01

    The purpose of this research was to investigate the validity and the reliability of 5-Hz MinimaxX global positioning system (GPS) units measuring athlete movement demands. A team sport simulation circuit (files collected from each unit = 12) and flying 50-m sprints (files collected from each unit = 34) were undertaken, during which the total distance covered; peak speed; player load; the distance covered; time spent and number of efforts performed walking, jogging, running, high-speed running, and sprinting were examined. Movement demands were also separately categorized into low-intensity activity, high-intensity running, and very high-intensity running. The results revealed that GPS was a valid and reliable measure of total distance covered (p > 0.05, percentage typical error of measurement [%TEM] 0.05, %TEM 5-10%). Further, GPS was found to be a reliable measure of player load (%TEM 4.9%) and the distance covered, time spent, and number of efforts performed at certain velocity zones (%TEM 10%). The level of GPS error was found to increase along with the velocity of exercise. The findings demonstrated that GPS is capable of measuring movement demands performed at velocities GPS velocities >20 km·h(-1).

  10. Metabolic Power Method: Underestimation of Energy Expenditure in Field-Sport Movements Using a Global Positioning System Tracking System.

    Science.gov (United States)

    Brown, Darcy M; Dwyer, Dan B; Robertson, Samuel J; Gastin, Paul B

    2016-11-01

    The purpose of this study was to assess the validity of a global positioning system (GPS) tracking system to estimate energy expenditure (EE) during exercise and field-sport locomotor movements. Twenty-seven participants each completed a 90-min exercise session on an outdoor synthetic futsal pitch. During the exercise session, they wore a 5-Hz GPS unit interpolated to 15 Hz and a portable gas analyzer that acted as the criterion measure of EE. The exercise session was composed of alternating 5-minute exercise bouts of randomized walking, jogging, running, or a field-sport circuit (×3) followed by 10 min of recovery. One-way analysis of variance showed significant (P GPS metabolic power- derived EE and oxygen-consumption (VO 2 ) -derived EE for all field-sport circuits (% difference ≈ -44%). No differences in EE were observed for the jog (7.8%) and run (4.8%), whereas very large overestimations were found for the walk (43.0%). The GPS metabolic power EE over the entire 90-min session was significantly lower (P GPS tracking system using the metabolic power model of EE does not accurately estimate EE in field-sport movements or over an exercise session consisting of mixed locomotor activities interspersed with recovery periods; however, is it able to provide a reasonably accurate estimation of EE during continuous jogging and running.

  11. Enhanced 911/global position system wizard: a telemedicine application for the prevention of severe hypoglycemia--monitor, alert, and locate.

    Science.gov (United States)

    Dassau, Eyal; Jovanovic, Lois; Doyle, Francis J; Zisser, Howard C

    2009-11-01

    Intensive insulin therapy has an inherent risk of hypoglycemia that can lead to loss of consciousness, cardiac arrhythmia, seizure, and death ("dead-in-bed syndrome"). This risk of hypoglycemia is a major concern for patients, families, and physicians. The need for an automated system that can alert in the event of severe hypoglycemia is evident. In engineering systems, where there is a risk of malfunction of the primary control system, alert and safety mechanisms are implemented in layers of protection. This concept has been adopted in the proposed system that integrates a hypoglycemia prediction algorithm with a global position system (GPS) locator and short message service such that the current glucose value with the rate of change (ROC) and the location of the subject can be communicated to a predefined list. Furthermore, if the system is linked to the insulin pump, it can suspend the pump or decrease the basal insulin infusion rate to prevent the pending event. The system was evaluated on clinical datasets of glucose tracings from the DexCom Seven system. Glucose tracings were analyzed for hypoglycemia events and then a text message was broadcast to a predefined list of people who were notified with the glucose value, ROC, GPS coordinates, and a Google map of the location. In addition to providing a safety layer to a future artificial pancreas, this system also can be easily implemented in current continuous glucose monitors to help provide information and alerts to people with diabetes.

  12. Study on cycle-slip detection and repair methods for a single dual-frequency global positioning system (GPS receiver

    Directory of Open Access Journals (Sweden)

    La Van Hieu

    Full Text Available In this work, we assessed the performance of the cycle-slip detection methods: Turbo Edit (TE, Melbourne-Wübbena wide-lane ambiguity (MWWL and forward and backward moving window averaging (FBMWA. The TE and MWWL methods were combined with ionospheric total electron content rate (TECR, and the FBMWA with second-order time-difference phase ionosphere residual (STPIR and TECR. Under different scenarios, 10 Global Positioning System (GPS datasets were used to assess the performance of the methods for cycle-slip detection. The MWWL-TECR delivered the best performance in detecting cycle-slips for 1 s data. The relative comparisons show that the FBMWA-TECR method performed slightly better than its original version, FBMWA-STPIR, detecting 100% and 73%, respectively. For data with a sample rate of 5 s, the FBMWA-TECR performed better than MWWL-TECR. However, the FBMWA is suitable only for post-processing, which refers to applications where the data are processed after the fact.

  13. K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

    DEFF Research Database (Denmark)

    Boecker, Werner; Stenman, Goeran; Loening, Thomas

    2013-01-01

    different cell lineages and define their cellular hierarchy in tumors with myoepithelial differentiation. isTILT analysis of a series of 28 breast, salivary, and lacrimal gland tumors, including pleomorphic adenomas (n=8), epithelial-myoepithelial tumors (n=9), and adenoid cystic carcinomas (n=11) revealed...... heterologeous cell differentiations such as squamous and mesenchymal progenies. p63 was co-expressed with K5/K14 in basal-like progenitor cells, myoepithelial, and squamous cells but not in glandular cells. Our results show that the corresponding counterpart tumors of breast and salivary/lacrimal glands have....... For that reason, we performed an in situ triple immunofluorescence lineage/differentiation tracing (isTILT) and qRT-PCR study of basal (K5/K14), glandular (K7/K8/18), and epidermal-specific squamous (K10) keratins, p63, and smooth muscle actin (SMA; myoepithelial marker) with the aim to construct and trace...

  14. Comprehensive Comparisons of Satellite Data, Signals, and Measurements between the BeiDou Navigation Satellite System and the Global Positioning System †

    Science.gov (United States)

    Jan, Shau-Shiun; Tao, An-Lin

    2016-01-01

    The Chinese BeiDou navigation satellite system (BDS) aims to provide global positioning service by 2020. The combined use of BDS and Global Positioning System (GPS) is proposed to provide navigation service with more stringent requirements. Actual satellite data, signals and measurements were collected for more than one month to analyze the positioning service qualities from both BDS and GPS. In addition to the conversions of coordinate and timing system, five data quality analysis (DQA) methods, three signal quality analysis (SQA) methods, and four measurement quality analysis (MQA) methods are proposed in this paper to improve the integrated positioning performance of BDS and GPS. As shown in the experiment results, issues related to BDS and GPS are resolved by the above proposed quality analysis methods. Thus, the anomalies in satellite data, signals and measurements can be detected by following the suggested resolutions to enhance the positioning performance of the combined use of BDS and GPS in the Asia Pacific region. PMID:27187403

  15. “His” and “Her” Marriage? The Role of Positive and Negative Marital Characteristics in Global Marital Satisfaction Among Older Adults

    Science.gov (United States)

    Jopp, Daniela S.; Carr, Deborah; Sosinsky, Laura; Kim, Se-Kang

    2014-01-01

    Objectives. We explore gender differences in older adults’ appraisals of positive and negative aspects of their marriages, examine how these appraisals relate to global marital satisfaction, and identify distinctive marital profiles associated with global satisfaction in men and women. Method. Data are from the Changing Lives of Older Couples Study (n = 1,110). We used a variant of principal components analysis to generate marital quality profiles, based on one’s endorsement of positive and negative marital characteristics. OLS regression was used to detect associations between marital profiles and global marital satisfaction. Results. Men offered more positive marital assessments than women, particularly on items reflecting positive treatment by one’s wife. Three marital quality profiles emerged: Positive, Positive–Negative, and Negative. Although marital satisfaction was best explained by positive appraisals in both genders, they were less important for men than for women. The negative profile showed a tendency for a stronger prediction in men. Discussion. Prior studies show small differences in men’s and women’s global marital satisfaction. Our work provides evidence that the presence and magnitude of such gender differences may vary based on the specific marital component considered. We discuss ways that gender shapes marital interactions, expectations, and perceptions, and the implications of our results for the well-being of married older adults. PMID:24742399

  16. Supplementary Material for: Global expression differences and tissue specific expression differences in rice evolution result in two contrasting types of differentially expressed genes

    KAUST Repository

    Horiuchi, Youko

    2015-01-01

    Abstract Background Since the development of transcriptome analysis systems, many expression evolution studies characterized evolutionary forces acting on gene expression, without explicit discrimination between global expression differences and tissue specific expression differences. However, different types of gene expression alteration should have different effects on an organism, the evolutionary forces that act on them might be different, and different types of genes might show different types of differential expression between species. To confirm this, we studied differentially expressed (DE) genes among closely related groups that have extensive gene expression atlases, and clarified characteristics of different types of DE genes including the identification of regulating loci for differential expression using expression quantitative loci (eQTL) analysis data. Results We detected differentially expressed (DE) genes between rice subspecies in five homologous tissues that were verified using japonica and indica transcriptome atlases in public databases. Using the transcriptome atlases, we classified DE genes into two types, global DE genes and changed-tissues DE genes. Global type DE genes were not expressed in any tissues in the atlas of one subspecies, however changed-tissues type DE genes were expressed in both subspecies with different tissue specificity. For the five tissues in the two japonica-indica combinations, 4.6 ± 0.8 and 5.9 ± 1.5 % of highly expressed genes were global and changed-tissues DE genes, respectively. Changed-tissues DE genes varied in number between tissues, increasing linearly with the abundance of tissue specifically expressed genes in the tissue. Molecular evolution of global DE genes was rapid, unlike that of changed-tissues DE genes. Based on gene ontology, global and changed-tissues DE genes were different, having no common GO terms. Expression differences of most global DE genes were regulated by cis

  17. Ways of Talking and Ways of Positioning: Students' Beliefs in an Inquiry-Oriented Differential Equations Class

    Science.gov (United States)

    Ju, Mi-Kyung; Kwon, Oh Nam

    2007-01-01

    As part of developmental research for an inquiry-oriented differential equations course, this study investigates the change in students' beliefs about mathematics. The discourse analysis has identified two different types of perspective modes--i.e., discourse of the third-person perspective and discourse of the first-person perspective--in the…

  18. On the existence of positive periodic solutions for totally nonlinear neutral differential equations of the second-order with functional delay

    Directory of Open Access Journals (Sweden)

    Emmanuel K. Essel

    2014-01-01

    Full Text Available We prove that the totally nonlinear second-order neutral differential equation \\[\\frac{d^2}{dt^2}x(t+p(t\\frac{d}{dt}x(t+q(th(x(t\\] \\[=\\frac{d}{dt}c(t,x(t-\\tau(t+f(t,\\rho(x(t,g(x(t-\\tau(t\\] has positive periodic solutions by employing the Krasnoselskii-Burton hybrid fixed point theorem.

  19. Accuracy and reliability of SPI ProX global positioning system devices for measuring movement demands of team sports.

    Science.gov (United States)

    Köklü, Y; Arslan, Y; Alemdaroğlu, U; Duffield, R

    2015-05-01

    The aim of this study was to determine the accuracy and reliability of SPI ProX global positioning system (GPS) devices for measuring movement at various speeds and movement patterns as evident in team sport demands. Eleven amateur soccer players performed a 40 m straight sprint test (with 10-20-30 m split times), a zigzag test, 30 m walking, jogging and moderate intensity runs. Results indicated that the SPI ProX GPS measurements showed acceptable accuracy for all movement patterns for distance (coefficient of variation [CV]=0.14% to 3.73%; 95% ratio limits of agreement [95% ratio LOA]=0.97 x / ÷ 1.09 to 1.00 x / ÷ 1.05) and speed (CV=4.22% to 9.52%; 95%LOA=-0.17 ± 1.70 km h-1 to 2.30 ± 1.17 km h-1) compared with the measured distance and speed determined from timing gates, respectively. Furthermore, acceptable reliability of SPI ProX GPS measures for distance (CV=0.34% to 3.81%; 95%LOA=-0.09 ± 0.23 m to -0.34 ± 2.31 m) and speed (CV=3.19% to 6.95%; 95%LOA=-0.05 ± 3.90 km h-1 to 0.42 ± 3.68 km h-1) were also evident. Whilst SPI ProX GPS devices were within acceptable ranges of reliability, they remained significantly different to criterion measures of team sport movement demands.

  20. Global positioning system data analysis: velocity ranges and a new definition of sprinting for field sport athletes.

    Science.gov (United States)

    Dwyer, Dan B; Gabbett, Tim J

    2012-03-01

    Global positioning system (GPS) technology has improved the speed, accuracy, and ease of time-motion analyses of field sport athletes. The large volume of numerical data generated by GPS technology is usually summarized by reporting the distance traveled and time spent in various locomotor categories (e.g., walking, jogging, and running). There are a variety of definitions used in the literature to represent these categories, which makes it nearly impossible to compare findings among studies. The purpose of this work was to propose standard definitions (velocity ranges) that were determined by an objective analysis of time-motion data. In addition, we discuss the limitations of the existing definition of a sprint and present a new definition of sprinting for field sport athletes. Twenty-five GPS data files collected from 5 different sports (men's and women's field hockey, men's and women's soccer, and Australian Rules Football) were analyzed to identify the average velocity distribution. A curve fitting process was then used to determine the optimal placement of 4 Gaussian curves representing the typical locomotor categories. Based on the findings of these analyses, we make recommendations about sport-specific velocity ranges to be used in future time-motion studies of field sport athletes. We also suggest that a sprint be defined as any movement that reaches or exceeds the sprint threshold velocity for at least 1 second and any movement with an acceleration that occurs within the highest 5% of accelerations found in the corresponding velocity range. From a practical perspective, these analyses provide conditioning coaches with information on the high-intensity sprinting demands of field sport athletes, while also providing a novel method of capturing maximal effort, short-duration sprints.

  1. On Fast Post-Processing of Global Positioning System Simulator Truth Data and Receiver Measurements and Solutions Data

    Science.gov (United States)

    Kizhner, Semion; Day, John H. (Technical Monitor)

    2000-01-01

    Post-Processing of data related to a Global Positioning System (GPS) simulation is an important activity in qualification of a GPS receiver for space flight. Because a GPS simulator is a critical resource it is desirable to move off the pertinent simulation data from the simulator as soon as a test is completed. The simulator data files are usually moved to a Personal Computer (PC), where the post-processing of the receiver logged measurements and solutions data and simulated data is performed. Typically post-processing is accomplished using PC-based commercial software languages and tools. Because of commercial software systems generality their general-purpose functions are notoriously slow and more than often are the bottleneck problem even for short duration experiments. For example, it may take 8 hours to post-process data from a 6-hour simulation. There is a need to do post-processing faster, especially in order to use the previous test results as feedback for a next simulation setup. This paper demonstrates that a fast software linear interpolation algorithm is applicable to a large class of engineering problems, like GPS simulation data post-processing, where computational time is a critical resource and is one of the most important considerations. An approach is developed that allows to speed-up post-processing by an order of magnitude. It is based on improving the post-processing bottleneck interpolation algorithm using apriori information that is specific to the GPS simulation application. The presented post-processing scheme was used in support of a few successful space flight missions carrying GPS receivers. A future approach to solving the post-processing performance problem using Field Programmable Gate Array (FPGA) technology is described.

  2. They go straight home - don't they? Using global positioning systems to assess adolescent school-travel patterns.

    Science.gov (United States)

    Voss, Christine; Winters, Meghan; Frazer, Amanda D; McKay, Heather A

    2014-12-01

    Active travel to school is a potential source of physical activity for adolescents, but its assessments often rely on assumptions around travel patterns. Global positioning system (GPS) and accelerometry provide an objective assessment of physical activity from school-travel and the context in which it occurs (where, when, how long). To describe school-travel patterns of adolescents and to compare estimates of physical activity during the hour before/after school - a commonly used proxy for school-travel time - with physical activity accrued during school trips identified through GPS ('GPS-trips'). Adolescents ( n =49, 13.3±0.7 years, 37% female) from Downtown Vancouver wore an accelerometer (GT3X+) and GPS (Qstarz) for 7 days (October 2012). Minutes of moderate-to-vigorous physical activity (MVPA) during the hour before/after school and during GPS-trips were calculated for the n =130 school-trips made by 43 students. We used multilevel linear regression to assess the association between MVPA during GPS-trips and MVPA during the hour/before school. Only 55% of school-trips were from/to home and within the hour before/after school ('normal'). Estimates of MVPA during the hour before/after school were higher than during GPS-trips (12.0 vs. 8.0 min). On average, MVPA during GPS-trips was linearly associated with MVPA during the hour before/after school, suggesting that physical activity levels during the hour before/after school are broadly reflective of physical activity from school-travel. GPS and accelerometry provide context-rich information relating to school-travel. The hour before/after school may - on average - provide a simple means to crudely estimate physical activity from school-travel when GPS are not available.

  3. Radiodine administration under suppression of TSH for identification of false positive receptions in patients with thyroid differentiated carcinoma (TDC): utility of the potassium perchlorate

    International Nuclear Information System (INIS)

    Santangelo, L.A.; Pitoia, F.; Sanz, C.; Niepomniszcze, H.; El Tamer, Elias

    2004-01-01

    The total body scan, after a dose of 131 I correlated with the measurement of stimulated Tg, constitute the principal pillars in follow-up of patients with TDC (thyroid differentiated carcinoma). A bibliographical search revealed more than 70 situations that can cause false total body scans positive. The examination is essential to avoid unnecessary treatment with radioiodine. The object is to evaluate the effectiveness of the radioiodine administration under hormonal therapy thyroid suppressive (THST) to eliminate the possibility of a false total body scan positive in five patients with TDC with stimulated Tg <1ng/ml

  4. Differential relationships in the association of the Big Five personality traits with positive mental health and psychopathology

    NARCIS (Netherlands)

    Lamers, S.M.A.; Westerhof, Gerben Johan; Kovács, Viktòria; Bohlmeijer, Ernst Thomas

    2012-01-01

    According to the two continua model of mental health, psychopathology and positive mental health (emotional, psychological, and social well-being) are related but distinct continua. This study investigates the two continua model by examining whether psychopathology and positive mental health show

  5. An Analysis of Mobility in Global Rankings: Making Institutional Strategic Plans and Positioning for Building World-Class Universities

    Science.gov (United States)

    Hou, Angela Yung Chi; Morse, Robert; Chiang, Chung-Lin

    2012-01-01

    Since the start of the twenty-first century, university rankings have become internationalized. Global rankings have a variety of uses, levels of popularity and rationales and they are here to stay. An examination of the results of the current global ranking reveals that well-reputed world-class universities are amongst the top ranked ones. A…

  6. An Assessment of Positive Organizational Behavior in Service Sector of Pakistan: Role of Organization Based Self-Esteem and Global Self-Esteem

    OpenAIRE

    Wafa Khurram; Kamariah Bte Ismail; Syed Khurram Ali Jafri; Khairiah Soehod

    2013-01-01

    This study is an attempt to investigate prevalence of positive organizational behavior in the organizations in the service sector of Pakistan. We tested effects of organization based self-esteem, role stressors (role conflict, role overload and role ambiguity), leader-member exchange and perceived organizational support on positive organizational behavior as well as mediation of organization-based-self-esteem in this regard. Moreover, moderation of global self-esteem was also estimated in rel...

  7. Improving sensitivity of linear regression-based cell type-specific differential expression deconvolution with per-gene vs. global significance threshold.

    Science.gov (United States)

    Glass, Edmund R; Dozmorov, Mikhail G

    2016-10-06

    The goal of many human disease-oriented studies is to detect molecular mechanisms different between healthy controls and patients. Yet, commonly used gene expression measurements from blood samples suffer from variability of cell composition. This variability hinders the detection of differentially expressed genes and is often ignored. Combined with cell counts, heterogeneous gene expression may provide deeper insights into the gene expression differences on the cell type-specific level. Published computational methods use linear regression to estimate cell type-specific differential expression, and a global cutoff to judge significance, such as False Discovery Rate (FDR). Yet, they do not consider many artifacts hidden in high-dimensional gene expression data that may negatively affect linear regression. In this paper we quantify the parameter space affecting the performance of linear regression (sensitivity of cell type-specific differential expression detection) on a per-gene basis. We evaluated the effect of sample sizes, cell type-specific proportion variability, and mean squared error on sensitivity of cell type-specific differential expression detection using linear regression. Each parameter affected variability of cell type-specific expression estimates and, subsequently, the sensitivity of differential expression detection. We provide the R package, LRCDE, which performs linear regression-based cell type-specific differential expression (deconvolution) detection on a gene-by-gene basis. Accounting for variability around cell type-specific gene expression estimates, it computes per-gene t-statistics of differential detection, p-values, t-statistic-based sensitivity, group-specific mean squared error, and several gene-specific diagnostic metrics. The sensitivity of linear regression-based cell type-specific differential expression detection differed for each gene as a function of mean squared error, per group sample sizes, and variability of the proportions

  8. Ultra-wideband technology radio frequency interference effects to global positioning system receivers and interference encounter scenario development : second interim report

    Science.gov (United States)

    2001-03-27

    The Global Positioning System (GPS) is significant because it is a key element in the development of the Free Flight" air traffic management structure of the future which is needed to enable the expected growth of air travel and alleviate the current...

  9. Global Positioning System (GPS) and Geographic Information System (GIS) analysis of mobile harvesting equipment and sediment delivery to streams during forest harvest operations on steep terrain: Experimental design

    Science.gov (United States)

    Daniel Bowker; Jeff Stringer; Chris Barton; Songlin. Fei

    2011-01-01

    Sediment mobilized by forest harvest machine traffic contributes substantially to the degradation of headwater stream systems. This study monitored forest harvest machine traffic to analyze how it affects sediment delivery to stream channels. Harvest machines were outfitted with global positioning system (GPS) dataloggers, recording machine movements and working status...

  10. Anthropometric and physical characteristics allow differentiation of young female volleyball players according to playing position and level of expertise

    Science.gov (United States)

    Milić, M; Grgantov, Z; Chamari, K; Bianco, A; Padulo, J

    2016-01-01

    The aim of our study was to determine the differences in some anthropometric and physical performance variables of young Croatian female volleyball players (aged 13 to 15) in relation to playing position (i.e., independent variable) and performance level within each position (i.e., independent variable). Players were categorized according to playing position (i.e., role) as middle blockers (n=28), opposite hitters (n=41), passer-hitters (n=54), setters (n=30), and liberos (n=28). Within each position, players were divided into a more successful group and a less successful group according to team ranking in the latest regional championship and player quality within the team. Height and body mass, somatotype by the Heath-Carter method, and four tests of lower body power, speed, agility and upper body power (i.e., dependent variables) were assessed. Players in different positions differed significantly in height and all three somatotype components, but no significant differences were found in body mass, body mass index or measured physical performance variables. Players of different performance level differed significantly in both anthropometric and physical performance variables. Generally, middle blockers were taller, more ectomorphic, less mesomorphic and endomorphic, whereas liberos were shorter, less ectomorphic, more mesomorphic and endomorphic than players in other positions. More successful players in all positions had a lower body mass index, were less mesomorphic and endomorphic, and more ectomorphic than less successful players. Furthermore, more successful players showed better lower body power, speed, agility and upper body power. The results of this study can potentially provide coaches with useful indications about the use of somatotype selection and physical performance assessment for talent identification and development. PMID:28416892

  11. The effect of the global positioning system on the driving performance of people with mild Alzheimer's disease.

    Science.gov (United States)

    Yi, Jewel; Lee, Hoe Chung-Yeung; Parsons, Richard; Falkmer, Torbjorn

    2015-01-01

    The initial symptoms of Alzheimer's disease (AD) include attention deficits, memory loss and deficiencies in topographic and spatial orientation. People with AD may have way-finding difficulties in driving due to the deterioration of their navigation ability. Although the use of the Global Positioning System (GPS) has been proven to be a useful aid for older people in driving, there is no evidence to suggest that the benefit could extend to drivers with AD. This study aims to investigate the effectiveness of the GPS in assisting drivers with mild AD in finding their destination safely. Twenty-eight drivers with mild to very mild AD, diagnosed by a general practitioner or a psychogeriatrician, completed all clinical and psychometric assessments including the Mini Mental State Examination, Trail Making Test B and Doors and People Test. During the driving assessment, 3 driving trials with different settings (normal, visual-only and audio-only) of the GPS were administered to all participants. The participants were required to follow instructions from the GPS and perform a variety of driving tasks on a driving simulator. The driving performances of participants were assessed by criteria specific to AD drivers. The driving assessment criteria were first combined to form the overall driving performance score: a higher score indicated a better overall driving performance. The other outcome of this study was the success of participants to navigate to a predetermined destination. The driving performance of participants was different among the 3 settings (F = 72.8, p driving performance score was highest in the audio-only setting (mean: 20.0, SD: 2.2), moderate in the normal setting (mean: 16.7, SD: 2.6) and lowest in the visual-only setting (mean: 14.3, SD: 3.3). When compared with the visual-only setting, drivers using the audio-only setting (OR: 37.2, 95% CI: 9.2-151.2) and normal setting (OR: 37.2, 95% CI: 4.8-286.9) were more likely to successfully find their

  12. Revising Reverse-Phase Chromatographic Behavior for Efficient Differentiation of Both Positional and Geometrical Isomers of Dicaffeoylquinic Acids

    Directory of Open Access Journals (Sweden)

    Keabetswe Masike

    2018-01-01

    Full Text Available Dicaffeoylquinic acids (diCQAs are plant metabolites and undergo trans-cis-isomerization when exposed to UV irradiation. As such, diCQAs exist in both trans- and cis-configurations and amplify the already complex plant metabolome. However, analytical differentiation of these geometrical isomers using mass spectrometry (MS approaches has proven to be extremely challenging. Exploring the chromatographic space to develop possible conditions that would aid in differentially separating and determining the elution order of these isomers is therefore imperative. In this study, simple chromatographic parameters, such as column chemistry (phenyl versus alkyl, mobile phase composition (methanol or acetonitrile, and column temperature, were investigated to aid in the separation of diCQA geometrical isomers. The high-performance liquid chromatography photodiode array (HPLC-PDA chromatograms revealed four isomers post UV irradiation of diCQA authentic standards. The elution profile/order was seen to vary on different reverse-phase column chemistries (phenyl versus alkyl using different mobile phase composition. Here, the elution profile/order on the phenyl-derived column matrices (with methanol as the mobile phase composition was observed to be relatively reproducible as compared to the alkyl (C18 columns. Chromatographic resolution of diCQA geometrical isomers can be enhanced with an increase in column temperature. Lastly, the study highlights that chromatographic elution order/profile cannot be relied upon to fathom the complexity of isomeric plant metabolites.

  13. Alexithymia Components Are Differentially Related to Explicit Negative Affect But Not Associated with Explicit Positive Affect or Implicit Affectivity.

    Science.gov (United States)

    Suslow, Thomas; Donges, Uta-Susan

    2017-01-01

    Alexithymia represents a multifaceted personality construct defined by difficulties in recognizing and verbalizing emotions and externally oriented thinking. According to clinical observations, experience of negative affects is exacerbated and experience of positive affects is decreased in alexithymia. Findings from research based on self-report indicate that all alexithymia facets are negatively associated with the experience of positive affects, whereas difficulties identifying and describing feelings are related to heightened negative affect. Implicit affectivity, which can be measured using indirect assessment methods, relates to processes of the impulsive system. The aim of the present study was to examine, for the first time, the relations between alexithymia components and implicit and explicit positive and negative affectivity in healthy adults. The 20-item Toronto Alexithymia Scale, the Implicit Positive and Negative Affect Test and the Positive and Negative Affect Schedule (PANAS) were administered to two hundred and forty-one healthy individuals along with measures of depression and trait anxiety. Difficulties identifying feelings were correlated with explicit negative trait affect, depressive mood and trait anxiety. Difficulties describing feelings showed smaller but also significant correlations with depressive mood and trait anxiety but were not correlated with explicit state or trait affect as assessed by the PANAS. Externally oriented thinking was not significantly correlated with any of the implicit and explicit affect measures. According to our findings, an externally oriented, concrete way of thinking appears to be generally unrelated to dispositions to develop positive or negative affects. Difficulties identifying feelings seem to be associated with increased conscious negative affects but not with a heightened disposition to develop negative affects at an automatic response level.

  14. Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation

    DEFF Research Database (Denmark)

    Reitelseder, Søren; Agergaard, Jakob; Doessing, Simon

    2014-01-01

    Purpose Resistance exercise and amino acid availability are positive regulators of muscle protein net balance (NB). However, anabolic responses to resistance exercise and protein supplementation deserve further elucidation. The purpose was to compare intakes of whey, caseinate (both: 0.30 g/kg lean...

  15. Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro

    International Nuclear Information System (INIS)

    Gustafsson, Anna C; Parasassi, Tiziana; Lundeberg, Joakim; Kupershmidt, Ilya; Edlundh-Rose, Esther; Greco, Giulia; Serafino, Annalucia; Krasnowska, Eva K; Lundeberg, Thomas; Bracci-Laudiero, Luisa; Romano, Maria-Concetta

    2005-01-01

    Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC). Studies at the cellular level have previously demonstrated that a single supplementation of NAC induces a ten-fold more rapid differentiation in normal primary human keratinocytes as well as a reversion of a colon carcinoma cell line from neoplastic proliferation to apical-basolateral differentiation [1]. The investigated cells showed an early change in the organization of the cytoskeleton, several newly established adherens junctions with E-cadherin/β-catenin complexes and increased focal adhesions, all features characterizing the differentiation process. In order to investigate the molecular mechanisms underlying the proliferation arrest and accelerated differentiation induced by NAC treatment of NHEK and Caco-2 cells in vitro, we performed global gene expression analysis of NAC treated cells in a time series (1, 12 and 24 hours post NAC treatment) using the Affymetrix GeneChip™ Human Genome U95Av2 chip, which contains approximately 12,000 previously characterized sequences. The treated samples were compared to the corresponding untreated culture at the same time point. Microarray data analysis revealed an increasing number of differentially expressed transcripts over time upon NAC treatment. The early response (1 hour) was transient, while a constitutive trend was commonly found among genes differentially regulated at later time points (12 and 24 hours). Connections to the induction of differentiation and inhibition of growth were identified for a majority of up- and down-regulated genes. All of the observed transcriptional changes, except for seven genes, were unique to either cell line. Only one gene, ID-1, was mutually regulated at 1 hour post treatment and might represent a common mediator of early NAC action. The detection of several genes that

  16. Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro

    Directory of Open Access Journals (Sweden)

    Bracci-Laudiero Luisa

    2005-07-01

    Full Text Available Abstract Background Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC. Studies at the cellular level have previously demonstrated that a single supplementation of NAC induces a ten-fold more rapid differentiation in normal primary human keratinocytes as well as a reversion of a colon carcinoma cell line from neoplastic proliferation to apical-basolateral differentiation 1. The investigated cells showed an early change in the organization of the cytoskeleton, several newly established adherens junctions with E-cadherin/β-catenin complexes and increased focal adhesions, all features characterizing the differentiation process. Methods In order to investigate the molecular mechanisms underlying the proliferation arrest and accelerated differentiation induced by NAC treatment of NHEK and Caco-2 cells in vitro, we performed global gene expression analysis of NAC treated cells in a time series (1, 12 and 24 hours post NAC treatment using the Affymetrix GeneChip™ Human Genome U95Av2 chip, which contains approximately 12,000 previously characterized sequences. The treated samples were compared to the corresponding untreated culture at the same time point. Results Microarray data analysis revealed an increasing number of differentially expressed transcripts over time upon NAC treatment. The early response (1 hour was transient, while a constitutive trend was commonly found among genes differentially regulated at later time points (12 and 24 hours. Connections to the induction of differentiation and inhibition of growth were identified for a majority of up- and down-regulated genes. All of the observed transcriptional changes, except for seven genes, were unique to either cell line. Only one gene, ID-1, was mutually regulated at 1 hour post treatment and might represent a common mediator of early NAC

  17. Differentiation of Boc-protected alpha,delta-/delta,alpha- and beta,delta-/delta,beta-hybrid peptide positional isomers by electrospray ionization tandem mass spectrometry.

    Science.gov (United States)

    Raju, G; Ramesh, V; Srinivas, R; Sharma, G V M; Shoban Babu, B

    2010-06-01

    Two new series of Boc-N-alpha,delta-/delta,alpha- and beta,delta-/delta,beta-hybrid peptides containing repeats of L-Ala-delta(5)-Caa/delta(5)-Caa-L-Ala and beta(3)-Caa-delta(5)-Caa/delta(5)-Caa-beta(3)-Caa (L-Ala = L-alanine, Caa = C-linked carbo amino acid derived from D-xylose) have been differentiated by both positive and negative ion electrospray ionization (ESI) ion trap tandem mass spectrometry (MS/MS). MS(n) spectra of protonated isomeric peptides produce characteristic fragmentation involving the peptide backbone, the Boc-group, and the side chain. The dipeptide positional isomers are differentiated by the collision-induced dissociation (CID) of the protonated peptides. The loss of 2-methylprop-1-ene is more pronounced for Boc-NH-L-Ala-delta-Caa-OCH(3) (1), whereas it is totally absent for its positional isomer Boc-NH-delta-Caa-L-Ala-OCH(3) (7), instead it shows significant loss of t-butanol. On the other hand, second isomeric pair shows significant loss of t-butanol and loss of acetone for Boc-NH-delta-Caa-beta-Caa-OCH(3) (18), whereas these are insignificant for its positional isomer Boc-NH-beta-Caa-delta-Caa-OCH(3) (13). The tetra- and hexapeptide positional isomers also show significant differences in MS(2) and MS(3) CID spectra. It is observed that 'b' ions are abundant when oxazolone structures are formed through five-membered cyclic transition state and cyclization process for larger 'b' ions led to its insignificant abundance. However, b(1)(+) ion is formed in case of delta,alpha-dipeptide that may have a six-membered substituted piperidone ion structure. Furthermore, ESI negative ion MS/MS has also been found to be useful for differentiating these isomeric peptide acids. Thus, the results of MS/MS of pairs of di-, tetra-, and hexapeptide positional isomers provide peptide sequencing information and distinguish the positional isomers. Copyright 2010 John Wiley & Sons, Ltd.

  18. Improving the Competitive Position in a Growing High Tech Industry : - Differentiation and Cost Leadership Strategies in Solar Photovoltaics -

    OpenAIRE

    Hrab, Dmytro; Yamkina, Oxana

    2011-01-01

    Background: The purpose of this master thesis was to investigate what generic strategies are utilized by big players in the solar photovoltaic industry to improve their competitive positions. The continuous expansion of the solar market indicated the significance of this research, since the correctly chosen strategy has a direct influence on the success and prosperity of the growing and developing high tech companies.Aim: The first aim of the study was to examine the applicability of Michael ...

  19. Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas.

    Directory of Open Access Journals (Sweden)

    Chun-Yi Chuang

    Full Text Available Human papillomavirus (HPV is a risk factor in a subset of oropharyngeal cancer; however, the contribution of HPV in the malignancy of oral squamous cell carcinomas (OSCC is not fully understood in Taiwanese. Herein, 61 patients with no risk factors and 117 patients with one or more risk factors were enrolled in this study. HPV16/18 infection rate in non-smokers, non-drinkers and non-betel quid chewers was higher than their counterparts. The development of HPV-infected cancer has been shown to be associated with interleukin-10 (IL-10 expression. To this end, IL-10 mRNA expression in OSCC tumors was evaluated by real-time RT-PCR. Data showed that HPV-positive patients had higher IL-10 mRNA levels than in HPV-negative patients. Kaplan-Meier and Cox-regression analysis indicated that the prognostic significance of IL-10 mRNA on overall survival and relapse free survival was only observed in HPV-positive OSCC, but not in HPV-negative OSCC. Mechanistically, the elevation of IL-10 by E6 was responsible for increased colony formation and migration capability in OSCC cells. Therefore, we suggest that IL-10 induced by E6 promotes cell growth and migration capability and consequent poor survival and relapse in HPV-positive OSCC.

  20. An Evaluation of Computerized Tests as Predictors of Job Performance: II. Differential Validity for Global and Job Element Criteria

    Science.gov (United States)

    1976-01-01

    provide more reliable and valid measures of performance than the commonly used global marks (Lawshe, 1952; Guion , 1965; Mecham & McCormick, 1969). Thus...Memory Test Radio Code Aptitude Test Electronic Technician Selection Test Shop Practices AFOT GCT ARI MECH CLER SONR RADO ETST SHOP...multiple regression for a global criterion were carried out using a modification of the methodology used in a study by Guion (1965). The

  1. Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Charles Meunier

    Full Text Available The Ccs3 locus on mouse chromosome 3 regulates differential susceptibility of A/J (A, susceptible and C57BL/6J (B6, resistant mouse strains to chemically-induced colorectal cancer (CRC. Here, we report the high-resolution positional mapping of the gene underlying the Ccs3 effect. Using phenotype/genotype correlation in a series of 33 AcB/BcA recombinant congenic mouse strains, as well as in groups of backcross populations bearing unique recombinant chromosomes for the interval, and in subcongenic strains, we have delineated the maximum size of the Ccs3 physical interval to a ∼2.15 Mb segment. This interval contains 12 annotated transcripts. Sequencing of positional candidates in A and B6 identified many either low-priority coding changes or non-protein coding variants. We found a unique copy number variant (CNV in intron 15 of the Nfkb1 gene. The CNV consists of two copies of a 54 bp sequence immediately adjacent to the exon 15 splice site, while only one copy is found in CRC-susceptible A. The Nfkb1 protein (p105/p50 expression is much reduced in A tumors compared to normal A colonic epithelium as analyzed by immunohistochemistry. Studies in primary macrophages from A and B6 mice demonstrate a marked differential activation of the NfκB pathway by lipopolysaccharide (kinetics of stimulation and maximum levels of phosphorylated IκBα, with a more robust activation being associated with resistance to CRC. NfκB has been previously implicated in regulating homeostasis and inflammatory response in the intestinal mucosa. The interval contains another positional candidate Slc39a8 that is differentially expressed in A vs B6 colons, and that has recently been associated in CRC tumor aggressiveness in humans.

  2. A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody.

    Science.gov (United States)

    Yamazaki, Kenji; Wakabayashi, Hiroshi; Suganami, Yu; Sano, Shinichi; Wakunami, Yu; Katayama, Takashi; Deguchi, Kentaro; Nagotani, Shoko; Kishida, Masayuki

    2017-08-01

    We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.

  3. Differential Risk for Homelessness Among US Male and Female Veterans With a Positive Screen for Military Sexual Trauma.

    Science.gov (United States)

    Brignone, Emily; Gundlapalli, Adi V; Blais, Rebecca K; Carter, Marjorie E; Suo, Ying; Samore, Matthew H; Kimerling, Rachel; Fargo, Jamison D

    2016-06-01

    Military sexual trauma (MST) is associated with adverse physical and mental health outcomes following military separation. Recent research suggests that MST may be a determinant in several factors associated with postdeployment homelessness. To evaluate MST as an independent risk factor for homelessness and to determine whether risk varies by sex. A retrospective cohort study of US veterans who used Veterans Health Administration (VHA) services between fiscal years 2004 and 2013 was conducted using administrative data from the Department of Defense and VHA. Included in the study were 601 892 US veterans deployed in Iraq or Afghanistan who separated from the military between fiscal years 2001 and 2011 and subsequently used VHA services. Positive response to screen for MST administered in VHA facilities. Administrative evidence of homelessness within 30 days, 1 year, and 5 years following the first VHA encounter after last deployment. The mean (SD) age of the 601 892 participants was 38.9 (9.4) years, 527 874 (87.7%) were male, 310 854 (51.6%) were white, and 382 361 (63.5%) were enlisted in the Army. Among veterans with a positive screen for MST, rates of homelessness were 1.6% within 30 days, 4.4% within 1 year, and 9.6% within 5 years, more than double the rates of veterans with a negative MST screen (0.7%, 1.8%, and 4.3%, respectively). A positive screen for MST was significantly and independently associated with postdeployment homelessness. In regression models adjusted for demographic and military service characteristics, odds of experiencing homelessness were higher among those who screened positive for MST compared with those who screened negative (30-day: adjusted odds ratio [AOR], 1.89; 95% CI, 1.58-2.24; 1-year: AOR, 2.27; 95% CI, 2.04-2.53; and 5-year: AOR, 2.63; 95% CI, 2.36-2.93). Military sexual trauma screen status remained independently associated with homelessness after adjusting for co-occurring mental health and substance abuse diagnoses

  4. Small shifts in craniotomy position in the lateral fluid percussion injury model are associated with differential lesion development.

    Science.gov (United States)

    Vink, R; Mullins, P G; Temple, M D; Bao, W; Faden, A I

    2001-08-01

    Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we observed considerable variability in localization and severity of tissue damage as a function of small changes in craniotomy position. To further address this issue, we examined the relationship between craniotomy position and brain lesion size/location in rats subjected to moderate FPI (2.28 +/- 0.18 atmospheres). With placement of a 5-mm craniotomy adjacent to the sagittal suture, there was both ipsilateral and contralateral damage as detected at 3 weeks posttrauma using T2-weighted magnetic resonance imaging (MRI). The MRI lesions were generally restricted to the hippocampus and subcortical layers. Shifting of the craniotomy site laterally was associated with increased ipsilateral tissue damage and a greater cortical component that correlated with distance from the sagittal suture. In contrast, the contralateral MRI lesion did not change significantly in size or location unless the center of the craniotomy was placed more than 3.5 mm from the sagittal suture, under which condition contralateral damage could no longer be detected. Ipsilateral tissue damage as determined from the MRI scans was linearly correlated to motor outcome but not with cognitive outcome as assessed by the Morris Water Maze. We conclude that craniotomy position is critical in determining extent and location of tissue injury produced during the lateral FPI model in rats. Addressing such potential variability is essential for studies that address either injury mechanisms or therapeutic treatments.

  5. Global Gene Expression Profiling and Alternative Splicing Events during the Chondrogenic Differentiation of Human Cartilage Endplate-Derived Stem Cells

    Directory of Open Access Journals (Sweden)

    Jin Shang

    2015-01-01

    Full Text Available Low back pain (LBP is a very prevalent disease and degenerative disc diseases (DDDs usually account for the LBP. However, the pathogenesis of DDDs is complicated and difficult to elucidate. Alternative splicing is a sophisticated regulatory process which greatly increases cellular complexity and phenotypic diversity of eukaryotic organisms. In addition, the cartilage endplate-derived stem cells have been discovered and identified by our research group. In this paper, we continue to investigate gene expression profiling and alternative splicing events during chondrogenic differentiation of cartilage endplate-derived stem cells. We adopted Affymetrix Human Transcriptome Array 2.0 (HTA 2.0 to compare the transcriptional and splicing changes between the control and differentiated samples. RT-PCR and quantitative PCR are used to validate the microarray results. The GO and KEGG pathway analysis was also performed. After bioinformatics analysis of the data, we detected 1953 differentially expressed genes. In terms of alternative splicing, the Splicing Index algorithm was used to select alternatively spliced genes. We detected 4411 alternatively spliced genes. GO and KEGG pathway analysis also revealed several functionally involved biological processes and signaling pathways. To our knowledge, this is the first study to investigate the alternative splicing mechanisms in chondrogenic differentiation of stem cells on a genome-wide scale.

  6. On oscillation and asymptotic behaviour of a neutral differential equation of first order with positive and negative coefficients

    Directory of Open Access Journals (Sweden)

    Prayag Prasad Mishra

    2007-01-01

    Full Text Available In this paper sufficient conditions are obtained so that every solution of $$ (y(t- p(ty(t-au'+ Q(tG(y(t-sigma-U(tG(y(t-alpha = f(t $$ tends to zero or to $pm infty$ as $t$ tends to $infty$, where $au ,sigma ,alpha$ are positive real numbers, $p,fin C([0,infty,R,Q,Uin C([0,infty,[0,infty$, and $Gin C(R,R$, $G$ is non decreasing with $xG(x>0$ for $ x eq 0$. The two primary assumptions in this paper are $int_{t_0}^{infty}Q(t=infty$ and $int_{t_0}^{infty}U(t

  7. Global diffusion tensor imaging derived metrics differentiate glioblastoma multiforme vs. normal brains by using discriminant analysis: introduction of a novel whole-brain approach.

    Science.gov (United States)

    Roldan-Valadez, Ernesto; Rios, Camilo; Cortez-Conradis, David; Favila, Rafael; Moreno-Jimenez, Sergio

    2014-06-01

    Histological behavior of glioblastoma multiforme suggests it would benefit more from a global rather than regional evaluation. A global (whole-brain) calculation of diffusion tensor imaging (DTI) derived tensor metrics offers a valid method to detect the integrity of white matter structures without missing infiltrated brain areas not seen in conventional sequences. In this study we calculated a predictive model of brain infiltration in patients with glioblastoma using global tensor metrics. Retrospective, case and control study; 11 global DTI-derived tensor metrics were calculated in 27 patients with glioblastoma multiforme and 34 controls: mean diffusivity, fractional anisotropy, pure isotropic diffusion, pure anisotropic diffusion, the total magnitude of the diffusion tensor, linear tensor, planar tensor, spherical tensor, relative anisotropy, axial diffusivity and radial diffusivity. The multivariate discriminant analysis of these variables (including age) with a diagnostic test evaluation was performed. The simultaneous analysis of 732 measures from 12 continuous variables in 61 subjects revealed one discriminant model that significantly differentiated normal brains and brains with glioblastoma: Wilks' λ = 0.324, χ(2) (3) = 38.907, p tensor and linear tensor. These metrics might be clinically applied for diagnosis, follow-up, and the study of other neurological diseases.

  8. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus.

    Science.gov (United States)

    Morita, Shuu; Tagai, Chihiro; Shiraishi, Takayuki; Miyaji, Kazuyuki; Iwamuro, Shawichi

    2013-10-01

    We previously reported the activities and modes of action of arginine (Arg)-rich histones H3 and H4 against Gram-negative bacteria. In the present study, we investigated the properties of the Arg-rich histones against Gram-positive bacteria in comparison with those of lysine (Lys)-rich histone H2B. In a standard microdilution assay, calf thymus histones H2B, H3, and H4 showed growth inhibitory activity against Staphylococcus aureus with minimum effective concentration values of 4.0, 4.0, and 5.6 μM, respectively. Laser confocal microscopic analyses revealed that both the Arg-rich and Lys-rich histones associated with the surface of S. aureus. However, while the morphology of S. aureus treated with histone H2B appeared intact, those treated with the histones H3 and H4 closely resembled each other, and the cells were blurred. Electrophoretic mobility shift assay results revealed these histones have binding affinity to lipoteichoic acid (LTA), one of major cell surface components of Gram-positive bacteria. Scanning electron microscopic analyses demonstrated that while histone H2B elicited no obvious changes in cell morphology, histones H3 and H4 disrupted the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides. Consequently, our results suggest that bacterial cell surface LTA initially attracts both the Arg- and Lys-rich histones, but the modes of antimicrobial action of these histones are different; the former involves cell membrane disruption and the latter involves the cell integrity disruption. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation.

    Directory of Open Access Journals (Sweden)

    Hironori Waki

    2011-10-01

    study demonstrates the utility of FAIRE-seq in providing a global view of cell type-specific regulatory elements in the genome and in identifying transcriptional regulators of adipocyte differentiation.

  10. The Number of Pathologically Positive Lymph Nodes and Pathological Tumor Depth Predicts Prognosis in Patients With Poorly Differentiated Squamous Cell Carcinoma of the Oral Cavity

    International Nuclear Information System (INIS)

    Kang, Chung-Jan; Lin, Chien-Yu; Wang, Hung-Ming; Fan, Kang-Hsing; Ng, Shu-Hang; Lee, Li-Yu; Chen, I-How; Huang, Shiang-Fu

    2011-01-01

    Purpose: The objective of this retrospective study was twofold: (1) to investigate prognostic factors for clinical outcomes in patients with poorly differentiated oral cavity squamous cell carcinoma and (2) to identify specific prognostic subgroups that may help to guide treatment decisions. Methods and Materials: We examined 102 patients with poorly differentiated oral cavity squamous cell carcinoma. All patients were followed for at least 24 months after surgery or until death. The 5-year rates of local control, neck control, distant metastasis, disease-free, disease-specific, and overall survival served as main outcome measures. Results: The 5-year rates were as follows: local control (79%), neck control (64%), distant metastases (27%), disease-free survival (48%), disease-specific survival (52%), and overall survival (42%). Multivariable analysis showed that the number of pathologically positive nodes (≥4 vs. ≤3) was a significant predictor of neck control, distant metastasis, and disease-free, disease-specific, and overall survival rates. In addition, the presence of tumor depth of ≥11 mm (vs. <11 mm) was a significant predictor of distant metastasis, disease-specific survival, and overall survival rates. The combination of the two predictors (26.5%, 27/102) was independently associated with poorer neck control (p = 0.0319), distant metastasis (p < 0.0001), and disease-free (p < 0.0001), disease-specific (p < 0.0001), and overall survival (p < 0.0001) rates. Conclusions: In patients with poorly differentiated oral cavity squamous cell carcinoma, the presence of at least 4 pathologically positive lymph nodes and of a pathological tumor depth ≥11 mm identifies a subset of subjects with poor clinical outcomes. Patients carrying both risk factors are suitable candidates for the development of novel therapeutic approaches.

  11. The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation

    International Nuclear Information System (INIS)

    Stuqui, Bruna; Conceição, André Luis Giacometti; Termini, Lara; Sichero, Laura; Villa, Luisa Lina; Rahal, Paula; Calmon, Marília de Freitas

    2016-01-01

    High-risk human papillomaviruses (HPVs) are strongly associated with the development of some malignancies. The E6 and E7 viral oncoproteins are the primary proteins responsible for cell homeostasis alteration and immortalization. Furthermore, the E6 protein from high-risk HPVs can interact with the PDZ (PSD-90/Dlg/ZO-1) domains of cellular proteins, triggering cell transformation. One protein that is associated with pathological conditions and has a PDZ domain is the protease HTRA1 (high temperature requirement 1). This protein is poorly expressed in some cancers, suggesting a tumor suppressor role. The aim of this study was to evaluate the effect of HTRA1 overexpression in HPV16-positive (CasKi) and HPV-negative (C33) cervical cell lines. The cells were transfected with a vector containing the HTRA1 ORF or an empty vector. HTRA1 overexpression was confirmed by qRT-PCR. The cells were subjected to cell proliferation, colony formation, apoptosis and cell cycle assays. C33 cells expressing HTRA1 grew significantly fewer colonies and showed less proliferation than cells without HTRA1 expression. In contrast, in the CasKi cells overexpressing HTRA1, there was an increase in the cell growth rate and in the colonies density compared to cells expressing low levels of HTRA1. An apoptosis assay showed that HTRA1 does not interfere with the apoptosis rate in these cells. A cell cycle immunofluorescence assay revealed more CasKi cells overexpressing HTRA1 in the S phase and more C33 HTRA1-transfected cells in the G0/G1 phase, suggesting that HTRA1 plays different roles in the cell cycle progression of these cells. HTRA1 overexpression prevents cell proliferation in the HPV-negative cell line and increases cell proliferation in the HPV-positive cell line. Although the E6/HTRA1 interaction has already been described in the literature, more studies are required to confirm whether the present functional findings are a result of this interaction

  12. Global Positioning System : significant challenges in sustaining and upgrading widely used capabilities : report to the Subcommittee on National Security and Foreign Affairs, Committee on Oversight and Government Reform, House of Representatives.

    Science.gov (United States)

    2009-04-01

    The Global Positioning System (GPS), which provides positioning, navigation, and timing data to users worldwide, has become essential to U.S. national security and a key tool in an expanding array of public service and commercial applications at home...

  13. Development of a metrological atomic force microscope with minimized Abbe error and differential interferometer-based real-time position control

    International Nuclear Information System (INIS)

    Ducourtieux, Sebastien; Poyet, Benoit

    2011-01-01

    A metrological atomic force microscope (mAFM) has been developed at LNE. It will be dedicated to traceable dimensional measurements and calibrations of transfer standards with a maximum size of 25 mm × 25 mm × 7 mm. The displacement range is 60 µm for the X and Y axes and 15 µm for the Z axis. The instrument uses four laser differential interferometers in an original Abbe-compliant arrangement to measure the position of the tip relative to the sample and to be directly traceable to the SI. The expected uncertainty for the measurement of the tip/sample relative position is 1 nm for the whole range without taking into account the tip contribution. To fulfill this specification, the design of the instrument has been optimized to minimize Abbe errors, to reduce the metrology loop length, to limit the drifts due to thermal dilatation and to improve the stability of interferometric position measurement in ambient air. To limit Abbe errors, a dedicated three-axis flexure stage has been developed to reduce parasitic rotational motion at the level of 1 µrad for the whole range. This stage is driven by piezo-actuators. The instrument controller is based on a FPGA combined with an embedded PXI controller to perform real-time control of the XYZ position. We present the design of the instrument and the very first results

  14. The whole is not the sum of its parts: Specific types of positive affect influence sleep differentially.

    Science.gov (United States)

    Pressman, Sarah D; Jenkins, Brooke N; Kraft-Feil, Tara L; Rasmussen, Heather; Scheier, Michael F

    2017-08-01

    Given the known detrimental effects of poor sleep on an array of psychological and physical health processes, it is critical to understand the factors that protect sleep, especially during times of stress when sleep particularly suffers. Positive affect (PA) arises as a variable of interest given its known associations with health and health behaviors and its ability to buffer stress. In 2 studies, we examined which types of PA (distinguished by arousal level and trait/state measurement) were most beneficial for sleep and whether these associations varied depending on the stress context. In Study 1, college students (N = 99) reported on their PA and sleep during the week of a major exam. In Study 2, 2 weeks of daily PA and sleep data were collected during a period with no examinations in a similar sample of students (N = 83). Results indicated that high trait vigor was tied to better sleep efficiency and quality, especially during high stress. Trait calm was generally unhelpful to sleep, and was related negatively to sleep duration. State calm, on the other hand, interacted with stress in Study 2 to predict more efficient day-to-day sleep on days with higher average stress. These findings illustrate the importance of considering arousal level, affect duration, and the stress context in studies of PA and health. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  15. Positive solutions of three-point boundary-value problems for p-Laplacian singular differential equations

    Directory of Open Access Journals (Sweden)

    George N. Galanis

    2005-10-01

    Full Text Available In this paper we prove the existence of positive solutions for the three-point singular boundary-value problem$$ -[phi _{p}(u']'=q(tf(t,u(t,quad 0

  16. Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines.

    Science.gov (United States)

    Friedline, J A; Garrett, S H; Somji, S; Todd, J H; Sens, D A

    1998-01-01

    The goal of this study was to determine which of the 10 functional metallothionein (MT) genes are expressed in four human breast cancer cell lines and whether expression varies among the cell lines. Using reverse transcription polymerase chain reaction (RT-PCR) technology, it was shown that there was no expression of mRNA for the MT-1A, MT-1B, MT-1F, MT-1G, MT-1H, MT-3, and MT-4 genes in any of the four cell lines. All four cell lines were shown to express mRNA for the MT-2A and MT-1X genes. The expression level of mRNA for the MT-2A gene demonstrated modest differences among the cell lines, whereas expression of the MT-1X gene was consistent. In contrast, mRNA for the MT-1E gene was expressed in only two of the four cell lines and expression correlated to the estrogen receptor status of the cell lines. The two estrogen-receptor-positive cell lines showed no mRNA expression for the MT-1E gene. In the two estrogen-receptor-negative cell lines, mRNA expression for the MT-1E gene was elevated with expression levels similar to the housekeeping gene, glyceraldehyde-3-phosphate dehydrogenase. The cellular content of MT protein was also shown to be elevated in the estrogen-receptor-negative cell lines that express MT-1E mRNA. These results suggest a possible relationship between estrogen receptor status and MT-1E gene expression in human breast cancer.

  17. Differential Effects of Intraoperative Positive End-expiratory Pressure (PEEP) on Respiratory Outcome in Major Abdominal Surgery Versus Craniotomy

    Science.gov (United States)

    Vidal Melo, Marcos F.; Staehr-Rye, Anne Kathrine; Bittner, Edward A.; Kurth, Tobias; Eikermann, Matthias

    2016-01-01

    Objectives In this study, we examined whether (1) positive end-expiratory pressure (PEEP) has a protective effect on the risk of major postoperative respiratory complications in a cohort of patients undergoing major abdominal surgeries and craniotomies, and (2) the effect of PEEP is differed by surgery type. Background Protective mechanical ventilation with lower tidal volumes and PEEP reduces compounded postoperative complications after abdominal surgery. However, data regarding the use of intraoperative PEEP is conflicting. Methods In this observational study, we included 5915 major abdominal surgery patients and 5063 craniotomy patients. Analysis was performed using multivariable logistic regression. The primary outcome was a composite of major postoperative respiratory complications (respiratory failure, reintubation, pulmonary edema, and pneumonia) within 3 days of surgery. Results Within the entire study population (major abdominal surgeries and craniotomies), we found an association between application of PEEP ≥5cmH2O and a decreased risk of postoperative respiratory complications compared with PEEP 5cmH2O was associated with a significant lower odds of respiratory complications in patients undergoing major abdominal surgery (odds ratio 0.53, 95% confidence interval 0.39 – 0.72), effects that translated to deceased hospital length of stay [median hospital length of stay : 6 days (4–9 days), incidence rate ratios for each additional day: 0.91 (0.84 - 0.98)], whereas PEEP >5cmH2O was not significantly associated with reduced odds of respiratory complications or hospital length of stay in patients undergoing craniotomy. Conclusions The protective effects of PEEP are procedure specific with meaningful effects observed in patients undergoing major abdominal surgery. Our data suggest that default mechanical ventilator settings should include PEEP of 5–10cmH2O during major abdominal surgery. PMID:26496082

  18. The promastigote surface antigen gene family of the Leishmania parasite: differential evolution by positive selection and recombination.

    Science.gov (United States)

    Devault, Alain; Bañuls, Anne-Laure

    2008-10-24

    PSA (promastigote surface antigen) is one of the major classes of membrane proteins present at the surface of the parasitic protozoan Leishmania. While it harbours leucine rich repeats, which are suggestive of its involvement in parasite-to-host physical interactions, its exact role is largely unknown. Furthermore, the extent of diversity of this gene family, both in copy number and sequence has not been established. From the newly available complete genome sequences of L. major, L. infantum and L. braziliensis, we have established the complete list of PSA genes, based on the conservation of specific domain architecture. The latter includes an array of leucine rich repeats of unique signature flanked by conserved cysteine-rich domains. All PSA genes code either for secreted or membrane-anchored surface proteins. Besides the few previously identified PSA genes, which are shown here to be part of a relatively large subclass of PSA genes located on chromosome 12, this study identifies seven other PSA subtypes. The latter, whose genes lie on chromosomes 5, 9, 21 and 31 in all three species, form single gene (two genes in one instance) subfamilies, which phylogenetically cluster as highly related orthologs. On the other hand, genes found on chromosome 12 generally show high diversification, as reflected in greater sequence divergence between species, and in an extended set of divergent paralogs. Moreover, we show that the latter genes are submitted to strong positive selection. We also provide evidence that evolution of these genes is driven by intra- and intergenic recombination, thereby modulating the number of LRRs in protein and generating chimeric genes. PSA is a Leishmania family of membrane-bound or secreted proteins, whose main signature consists in a specific LRR sequence. All PSA genes found in the genomes of three sequenced Leishmania species unambiguously distribute into eight subfamilies of orthologs. Seven of these are evolving relatively slowly and could

  19. The promastigote surface antigen gene family of the Leishmania parasite: differential evolution by positive selection and recombination

    Directory of Open Access Journals (Sweden)

    Bañuls Anne-Laure

    2008-10-01

    Full Text Available Abstract Background PSA (promastigote surface antigen is one of the major classes of membrane proteins present at the surface of the parasitic protozoan Leishmania. While it harbours leucine rich repeats, which are suggestive of its involvement in parasite-to-host physical interactions, its exact role is largely unknown. Furthermore, the extent of diversity of this gene family, both in copy number and sequence has not been established. Results From the newly available complete genome sequences of L. major, L. infantum and L. braziliensis, we have established the complete list of PSA genes, based on the conservation of specific domain architecture. The latter includes an array of leucine rich repeats of unique signature flanked by conserved cysteine-rich domains. All PSA genes code either for secreted or membrane-anchored surface proteins. Besides the few previously identified PSA genes, which are shown here to be part of a relatively large subclass of PSA genes located on chromosome 12, this study identifies seven other PSA subtypes. The latter, whose genes lie on chromosomes 5, 9, 21 and 31 in all three species, form single gene (two genes in one instance subfamilies, which phylogenetically cluster as highly related orthologs. On the other hand, genes found on chromosome 12 generally show high diversification, as reflected in greater sequence divergence between species, and in an extended set of divergent paralogs. Moreover, we show that the latter genes are submitted to strong positive selection. We also provide evidence that evolution of these genes is driven by intra- and intergenic recombination, thereby modulating the number of LRRs in protein and generating chimeric genes. Conclusion PSA is a Leishmania family of membrane-bound or secreted proteins, whose main signature consists in a specific LRR sequence. All PSA genes found in the genomes of three sequenced Leishmania species unambiguously distribute into eight subfamilies of orthologs

  20. RNA-Seq and microarrays analyses reveal global differential transcriptomes of Mesorhizobium huakuii 7653R between bacteroids and free-living cells.

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    Jieli Peng

    Full Text Available Mesorhizobium huakuii 7653R occurs either in nitrogen-fixing symbiosis with its host plant, Astragalus sinicus, or free-living in the soil. The M. huakuii 7653R genome has recently been sequenced. To better understand the complex biochemical and developmental changes that occur in 7653R during bacteroid development, RNA-Seq and Microarrays were used to investigate the differential transcriptomes of 7653R bacteroids and free-living cells. The two approaches identified several thousand differentially expressed genes. The most prominent up-regulation occurred in the symbiosis plasmids, meanwhile gene expression is concentrated to a set of genes (clusters in bacteroids to fulfill corresponding functional requirements. The results suggested that the main energy metabolism is active while fatty acid metabolism is inactive in bacteroid and that most of genes relevant to cell cycle are down-regulated accordingly. For a global analysis, we reconstructed a protein-protein interaction (PPI network for 7653R and integrated gene expression data into the network using Cytoscape. A highly inter-connected subnetwork, with function enrichment for nitrogen fixation, was found, and a set of hubs and previously uncharacterized genes participating in nitrogen fixation were identified. The results described here provide a broader biological landscape and novel insights that elucidate rhizobial bacteroid differentiation, nitrogen fixation and related novel gene functions.

  1. Core Genome Multilocus Sequence Typing for Identification of Globally Distributed Clonal Groups and Differentiation of Outbreak Strains of Listeria monocytogenes

    OpenAIRE

    Chen, Yi; Gonzalez-Escalona, Narjol; Hammack, Thomas S.; Allard, Marc W.; Strain, Errol A.; Brown, Eric W.

    2016-01-01

    ABSTRACT Many listeriosis outbreaks are caused by a few globally distributed clonal groups, designated clonal complexes or epidemic clones, of Listeria monocytogenes, several of which have been defined by classic multilocus sequence typing (MLST) schemes targeting 6 to 8 housekeeping or virulence genes. We have developed and evaluated core genome MLST (cgMLST) schemes and applied them to isolates from multiple clonal groups, including those associated with 39 listeriosis outbreaks. The cgMLST...

  2. Uptake of 131-I in maxillary bones mimicking salivary glands. False- positive images in patients with differentiated thyroid carcinoma (DTC )

    International Nuclear Information System (INIS)

    Degrossi, Osvaldo J.; Degrossi, E.B.; Levi de Cabrejas, Mariana

    2008-01-01

    with the intensity of the administered activity of radioiodine, the previous condition of dental integrity and in patients living in the interior of our country in zones of 'bad' water containing tracers of arsenic and fluorine. In 13 patients submitted to intense treatment of dental problems posterior WBS showed a decrease of the positive maxilla areas or they were not found. The presence of metastasis in the active maxilla area was in all cases negative. Our observations confirm that radioiodine is deposited in maxillary bone in relation of dental lesions and that this 131-I move in a very slow place. This mechanism of fixation has to be determined. We fully recommended taking into account the existence of dental illness or incomplete dental treatments when the administration of higher activities than 3.7 GBq (150 mCi). (author) [es

  3. Citizen Journalism and Digital Voices: Instituting a Collaborative Process between Global Youth, Technology and Media for Positive Social Change

    Science.gov (United States)

    Worley, Robin

    2011-01-01

    Millions of youths in developing countries are described by UNICEF as "invisible and excluded." They live at the margins of society, facing challenges to their daily existence, powerless to make positive changes. But the emergence of citizen journalism and digital storytelling may offer these youths a chance to share their voices and…

  4. Dynamical Approach Study of Spurious Steady-State Numerical Solutions of Nonlinear Differential Equations. Part 2; Global Asymptotic Behavior of Time Discretizations

    Science.gov (United States)

    Yee, H. C.; Sweby, P. K.

    1995-01-01

    The global asymptotic nonlinear behavior of 11 explicit and implicit time discretizations for four 2 x 2 systems of first-order autonomous nonlinear ordinary differential equations (ODEs) is analyzed. The objectives are to gain a basic understanding of the difference in the dynamics of numerics between the scalars and systems of nonlinear autonomous ODEs and to set a baseline global asymptotic solution behavior of these schemes for practical computations in computational fluid dynamics. We show how 'numerical' basins of attraction can complement the bifurcation diagrams in gaining more detailed global asymptotic behavior of time discretizations for nonlinear differential equations (DEs). We show how in the presence of spurious asymptotes the basins of the true stable steady states can be segmented by the basins of the spurious stable and unstable asymptotes. One major consequence of this phenomenon which is not commonly known is that this spurious behavior can result in a dramatic distortion and, in most cases, a dramatic shrinkage and segmentation of the basin of attraction of the true solution for finite time steps. Such distortion, shrinkage and segmentation of the numerical basins of attraction will occur regardless of the stability of the spurious asymptotes, and will occur for unconditionally stable implicit linear multistep methods. In other words, for the same (common) steady-state solution the associated basin of attraction of the DE might be very different from the discretized counterparts and the numerical basin of attraction can be very different from numerical method to numerical method. The results can be used as an explanation for possible causes of error, and slow convergence and nonconvergence of steady-state numerical solutions when using the time-dependent approach for nonlinear hyperbolic or parabolic PDEs.

  5. Value of 201Tl imaging in predicting therapeutic 131I uptake in patients with thyroglobulin-positive but 131I scan-negative differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Conlu, R.A.O.; Obaldo, J.M.

    2004-01-01

    Background: Serum thyroglobulin assay and 131Iodine (1311) whole body scan are considered complementary in detecting malignant thyroid tissue or metastases. A large number of patients, however, are encountered presenting with scan-negative, thyroglobulin-positive differentiated thyroid carcinoma posing a dilemma in therapeutic management. One of the first alternative scanning agents to be employed is 201Thallium (201Tl). Recent studies have demonstrated its usefulness in identifying lesions that are not visualized with traditional 131I whole body scan. It is not clear, however, whether 201Tl scan helps in the decision-making for subsequent 131I therapy. This study was conducted to determine if 201Tl scan can predict therapeutic 131I uptake and to define the clinical role of 201Tl scanning in these patients. Methods and results: A total of 12 patients (20-63 y/o), 5 males and 7 females, underwent surgery for differentiated thyroid cancer and all had serum thyroglobulin values above 10 ng/ml and normal TPO autoantibodies. Pre-therapy 131I scan using 111 MBq (3mCi) of 131I were obtained. As required for inclusion, all patients had negative pre-therapy scan and negative TPO autoantibody results and underwent 20lTl scanning within 3 weeks. All patients were given 131I therapy (3.7-5.5 GBq or 100-150 mCi) between one to two months after 201Tl scanning. Within a week after therapy, all patients underwent whole body 1311 scanning. 201Tl imaging demonstrated thyroid remnants in 9 out of 12 patients having positive 201Tl scan but negative pre-therapy 1311 scan. However, only 2 of the positive 201Tl scans showed 131I uptake post-therapy (positive predictive value of 20%). None of the subjects presented with a negative 201Tl scan and a positive post-therapy 131I scan. Conclusion: Our study suggests that evidence of remnants or metastases on 201Tl scanning may be an inappropriate basis for the decision to proceed with 131I therapy. The role of 20lTl imaging in this subset of

  6. A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation

    Science.gov (United States)

    Cheong, Mei-Leng; Wang, Liang-Jie; Chuang, Pei-Yun; Chang, Ching-Wen; Lee, Yun-Shien; Lo, Hsiao-Fan; Tsai, Ming-Song

    2015-01-01

    Human chorionic gonadotropin (hCG) is composed of a common α subunit and a placenta-specific β subunit. Importantly, hCG is highly expressed in the differentiated and multinucleated syncytiotrophoblast, which is formed via trophoblast cell fusion and stimulated by cyclic AMP (cAMP). Although the ubiquitous activating protein 2 (AP2) transcription factors TFAP2A and TFAP2C may regulate hCGβ expression, it remains unclear how cAMP stimulates placenta-specific hCGβ gene expression and trophoblastic differentiation. Here we demonstrated that the placental transcription factor glial cells missing 1 (GCM1) binds to a highly conserved promoter region in all six hCGβ paralogues by chromatin immunoprecipitation-on-chip (ChIP-chip) analyses. We further showed that cAMP stimulates GCM1 and the CBP coactivator to activate the hCGβ promoter through a GCM1-binding site (GBS1), which also constitutes a previously identified AP2 site. Given that TFAP2C may compete with GCM1 for GBS1, cAMP enhances the association between the hCGβ promoter and GCM1 but not TFAP2C. Indeed, the hCG-cAMP-protein kinase A (PKA) signaling pathway also stimulates Ser269 and Ser275 phosphorylation of GCM1, which recruits CBP to mediate GCM1 acetylation and stabilization. Consequently, hCG stimulates the expression of GCM1 target genes, including the fusogenic protein syncytin-1, to promote placental cell fusion. Our study reveals a positive feedback loop between GCM1 and hCG regulating placental hCGβ expression and cell differentiation. PMID:26503785

  7. A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation.

    Science.gov (United States)

    Cheong, Mei-Leng; Wang, Liang-Jie; Chuang, Pei-Yun; Chang, Ching-Wen; Lee, Yun-Shien; Lo, Hsiao-Fan; Tsai, Ming-Song; Chen, Hungwen

    2016-01-01

    Human chorionic gonadotropin (hCG) is composed of a common α subunit and a placenta-specific β subunit. Importantly, hCG is highly expressed in the differentiated and multinucleated syncytiotrophoblast, which is formed via trophoblast cell fusion and stimulated by cyclic AMP (cAMP). Although the ubiquitous activating protein 2 (AP2) transcription factors TFAP2A and TFAP2C may regulate hCGβ expression, it remains unclear how cAMP stimulates placenta-specific hCGβ gene expression and trophoblastic differentiation. Here we demonstrated that the placental transcription factor glial cells missing 1 (GCM1) binds to a highly conserved promoter region in all six hCGβ paralogues by chromatin immunoprecipitation-on-chip (ChIP-chip) analyses. We further showed that cAMP stimulates GCM1 and the CBP coactivator to activate the hCGβ promoter through a GCM1-binding site (GBS1), which also constitutes a previously identified AP2 site. Given that TFAP2C may compete with GCM1 for GBS1, cAMP enhances the association between the hCGβ promoter and GCM1 but not TFAP2C. Indeed, the hCG-cAMP-protein kinase A (PKA) signaling pathway also stimulates Ser269 and Ser275 phosphorylation of GCM1, which recruits CBP to mediate GCM1 acetylation and stabilization. Consequently, hCG stimulates the expression of GCM1 target genes, including the fusogenic protein syncytin-1, to promote placental cell fusion. Our study reveals a positive feedback loop between GCM1 and hCG regulating placental hCGβ expression and cell differentiation. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  8. Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation.

    Directory of Open Access Journals (Sweden)

    Michaela Frye

    2007-08-01

    Full Text Available Activation of Myc induces epidermal stem cells to exit their niche and differentiate into sebocytes and interfollicular epidermis, a process that is associated with widespread changes in gene transcription. We have identified chromatin modifications that are characteristic of epidermal stem cells and investigated the effects of Myc activation. Quiescent stem cells in the interfollicular epidermis and the hair follicle bulge had high levels of tri-methylated histone H3 at lysine 9 and H4 at lysine 20. Chromatin in both stem cell populations was hypoacteylated at histone H4 and lacked mono-methylation of histone H4 at lysine 20. Myc-induced exit from the stem cell niche correlated with increased acetylation at histone H4 and transiently increased mono-methylation at lysine 20. The latter was replaced by epigenetic modifications that are largely associated with chromatin silencing: di-methylation at histone H3 lysine 9 and histone H4 lysine 20. These modifications correlated with changes in the specific histone methyltransferases Set8 and Ash-1. The Myc-induced switch from mono- to di-methylated H4K20 required HDAC activity and was blocked by the HDAC inhibitor trichostatin A (TSA. TSA treatment induced a similar epidermal phenotype to activation of Myc, and activation of Myc in the presence of TSA resulted in massive stimulation of terminal differentiation. We conclude that Myc-induced chromatin modifications play a major role in Myc-induced exit from the stem cell compartment.

  9. Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses.

    Science.gov (United States)

    Cho, Hyelim; Proll, Sean C; Szretter, Kristy J; Katze, Michael G; Gale, Michael; Diamond, Michael S

    2013-04-01

    Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outcome, little is known about the molecular factors governing this vulnerability. Here we show that two types of neurons from distinct brain regions showed differential permissivity to replication of several positive-stranded RNA viruses. Granule cell neurons of the cerebellum and cortical neurons from the cerebral cortex have unique innate immune programs that confer differential susceptibility to viral infection ex vivo and in vivo. By transducing cortical neurons with genes that were expressed more highly in granule cell neurons, we identified three interferon-stimulated genes (ISGs; Ifi27, Irg1 and Rsad2 (also known as Viperin)) that mediated the antiviral effects against different neurotropic viruses. Moreover, we found that the epigenetic state and microRNA (miRNA)-mediated regulation of ISGs correlates with enhanced antiviral response in granule cell neurons. Thus, neurons from evolutionarily distinct brain regions have unique innate immune signatures, which probably contribute to their relative permissiveness to infection.

  10. Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.

    Science.gov (United States)

    Diler, Rasim Somer; de Almeida, Jorge Renner Cardoso; Ladouceur, Cecile; Birmaher, Boris; Axelson, David; Phillips, Mary

    2013-12-30

    Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1 ± 1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  11. Two faces of group-based shame: moral shame and image shame differentially predict positive and negative orientations to ingroup wrongdoing.

    Science.gov (United States)

    Allpress, Jesse A; Brown, Rupert; Giner-Sorolla, Roger; Deonna, Julien A; Teroni, Fabrice

    2014-10-01

    This article proposes distinctions between guilt and two forms of shame: Guilt arises from a violated norm and is characterized by a focus on specific behavior; shame can be characterized by a threatened social image (Image Shame) or a threatened moral essence (Moral Shame). Applying this analysis to group-based emotions, three correlational studies are reported, set in the context of atrocities committed by (British) ingroup members during the Iraq war (Ns = 147, 256, 399). Results showed that the two forms of shame could be distinguished. Moreover, once the other form of shame was controlled for, they were differentially related to orientations toward the outgroup: Image Shame was associated with negative orientations, whereas Moral Shame had associations with positive outgroup orientations. These associations were distinct from the associations of guilt and rejection. Study 3 used a longitudinal design and provided evidence suggestive of a causal direction from emotions to outgroup orientation. © 2014 by the Society for Personality and Social Psychology, Inc.

  12. Characteristics of atmospheric gravity waves observed using the MU (Middle and Upper atmosphere) radar and GPS (Global Positioning System) radio occultation.

    Science.gov (United States)

    Tsuda, Toshitaka

    2014-01-01

    The wind velocity and temperature profiles observed in the middle atmosphere (altitude: 10-100 km) show perturbations resulting from superposition of various atmospheric waves, including atmospheric gravity waves. Atmospheric gravity waves are known to play an important role in determining the general circulation in the middle atmosphere by dynamical stresses caused by gravity wave breaking. In this paper, we summarize the characteristics of atmospheric gravity waves observed using the middle and upper atmosphere (MU) radar in Japan, as well as novel satellite data obtained from global positioning system radio occultation (GPS RO) measurements. In particular, we focus on the behavior of gravity waves in the mesosphere (50-90 km), where considerable gravity wave attenuation occurs. We also report on the global distribution of gravity wave activity in the stratosphere (10-50 km), highlighting various excitation mechanisms such as orographic effects, convection in the tropics, meteorological disturbances, the subtropical jet and the polar night jet.

  13. Dataset of differential lipid raft and global proteomes of SILAC-labeled cystic fibrosis cells upon TNF -α stimulation

    Directory of Open Access Journals (Sweden)

    C. Chhuon

    2016-12-01

    We used the Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC approach to quantify and identify 332 proteins in LRM upon TNF-a stimulation in CF cells and 1381 for the global proteome. We report two detailed tables containing lists of proteins obtained by mass spectrometry and the immunofluorescence validation results for one of these proteins, the G-protein coupled receptor 5A. These results are associated with the article “Changes in lipid raft proteome upon TNF-α stimulation of cystic fibrosis cells” (Chhuon et al., in press [1].

  14. Coaching to vision versus coaching to improvement needs: a preliminary investigation on the differential impacts of fostering positive and negative emotion during real time executive coaching sessions.

    Science.gov (United States)

    Howard, Anita R

    2015-01-01

    Drawing on intentional change theory (ICT; Boyatzis, 2006), this study examined the differential impact of inducing coaching recipients' vision/positive emotion versus improvement needs/negative emotion during real time executive coaching sessions. A core aim of the study was to empirically test two central ICT propositions on the effects of using the coached person's Positive Emotional Attractor (vision/PEA) versus Negative Emotional Attractor (improvement needs/NEA) as the anchoring framework of a onetime, one-on-one coaching session on appraisal of 360° feedback and discussion of possible change goals. Eighteen coaching recipients were randomly assigned to two coaching conditions, the coaching to vision/PEA condition and the coaching to improvement needs/NEA condition. Two main hypotheses were tested. Hypothesis1 predicted that participants in the vision/PEA condition would show higher levels of expressed positive emotion during appraisal of 360° feedback results and discussion of change goals than recipients in the improvement needs/NEA condition. Hypothesis2 predicted that vision/PEA participants would show lower levels of stress immediately after the coaching session than improvement needs/NEA participants. Findings showed that coaching to vision/the PEA fostered significantly lower levels of expressed negative emotion and anger during appraisal of 360° feedback results as compared to coaching to improvements needs/the NEA. Vision-focused coaching also fostered significantly greater exploration of personal passions and future desires, and more positive engagement during 360° feedback appraisal. No significant differences between the two conditions were found in emotional processing during discussion of change goals or levels of stress immediately after the coaching session. Current findings suggest that vision/PEA arousal versus improvement needs/NEA arousal impact the coaching process in quite different ways; that the coach's initial framing of the

  15. International climate protection legislation. The way towards a global climate agreement in the sense of common but differentiated responsibility

    International Nuclear Information System (INIS)

    Jahrmarkt, Lena

    2016-01-01

    Climate Change is one of the most important issues in the 21st century. Its extensive impacts regarding society, policy, economy and environment and its threats require an effective reaction at the international level. But does the newly adopted Paris Agreement comply to the expectations? Or how could an effective Climate Agreement be achieved to meet climate effectiveness and climate justice? To answer these questions this study analyses the development of international climate change law in a comprehensive way. In combination with analysing the principle of common, but differentiated responsibility it is possible to present new aspects for a climate Agreement by learning from failures of the past and embracing the raising threat brought about by climate change.

  16. Differentiation of Positional Isomers of Hybrid Peptides Containing Repeats of β-Nucleoside Derived Amino Acid (β-Nda-) and L-Amino Acids by Positive and Negative Ion Electrospray Ionization Tandem Mass Spectrometry (ESI-MS n )

    Science.gov (United States)

    Raju, B.; Ramesh, M.; Srinivas, R.; Chandrasekhar, S.; Kiranmai, N.; Sarma, V. U. M.

    2011-04-01

    A new class of positional isomeric pairs of -Boc protected oligopeptides comprised of alternating nucleoside derived β-amino acid (β-Nda-) and L-amino acid residues (alanine, valine, and phenylalanine) have been differentiated by both positive and negative ion electrospray ionization ion-trap tandem mass spectrometry (ESI-MS n ). The protonated dipeptide positional isomers with β-Nda- at the N-terminus lose CH3OH, NH3, and C2H4O2, whereas these processes are absent for the peptides with L-amino acids at the N-terminus. Instead, the presence of L-amino acids at the N-terminus results in characteristic retro-Mannich reaction involving elimination of imine. A good correlation has been observed between the conformational structure of the peptides and the abundance of y{n/+} and b{n/+} ions in MS n spectra. In the case of tetrapeptide isomers that are reported to form helical structures in solution phase, no y{n/+} and b{n/+} ions are observed when the corresponding amide -NH- participates in the helical structures. In contrast, significant y{n/+} and b{n/+} ions are formed when the amide -NH- is not involved in the H-bonding. In the case of tetra- and hexapeptides, it is observed that abundant b{n/+} ions are formed, presumably with stable oxazolone structures when the C-terminus of the b{n/+} ions possessed L-amino acid and the β-Nda- at the C-terminus appears to prevent the cyclization process leading to the absence of corresponding b{n/+} ions.

  17. Transcriptome profiling and pathway analysis of genes expressed differentially in participants with or without a positive response to topiramate treatment for methamphetamine addiction.

    Science.gov (United States)

    Li, Ming D; Wang, Ju; Niu, Tianhua; Ma, Jennie Z; Seneviratne, Chamindi; Ait-Daoud, Nassima; Saadvandi, Jim; Morris, Rana; Weiss, David; Campbell, Jan; Haning, William; Mawhinney, David J; Weis, Denis; McCann, Michael; Stock, Christopher; Kahn, Roberta; Iturriaga, Erin; Yu, Elmer; Elkashef, Ahmed; Johnson, Bankole A

    2014-12-12

    Developing efficacious medications to treat methamphetamine dependence is a global challenge in public health. Topiramate (TPM) is undergoing evaluation for this indication. The molecular mechanisms underlying its effects are largely unknown. Examining the effects of TPM on genome-wide gene expression in methamphetamine addicts is a clinically and scientifically important component of understanding its therapeutic profile. In this double-blind, placebo-controlled clinical trial, 140 individuals who met the DSM-IV criteria for methamphetamine dependence were randomized to receive either TPM or placebo, of whom 99 consented to participate in our genome-wide expression study. The RNA samples were collected from whole blood for 50 TPM- and 49 placebo-treated participants at three time points: baseline and the ends of weeks 8 and 12. Genome-wide expression profiles and pathways of the two groups were compared for the responders and non-responders at Weeks 8 and 12. To minimize individual variations, expression of all examined genes at Weeks 8 and 12 were normalized to the values at baseline prior to identification of differentially expressed genes and pathways. At the single-gene level, we identified 1054, 502, 204, and 404 genes at nominal P values treatment of methamphetamine addicts significantly modulates the expression of genes involved in multiple biological processes underlying addiction behavior and other physiological functions.

  18. Promoter Analysis Reveals Globally Differential Regulation of Human Long Non-Coding RNA and Protein-Coding Genes

    KAUST Repository

    Alam, Tanvir

    2014-10-02

    Transcriptional regulation of protein-coding genes is increasingly well-understood on a global scale, yet no comparable information exists for long non-coding RNA (lncRNA) genes, which were recently recognized to be as numerous as protein-coding genes in mammalian genomes. We performed a genome-wide comparative analysis of the promoters of human lncRNA and protein-coding genes, finding global differences in specific genetic and epigenetic features relevant to transcriptional regulation. These two groups of genes are hence subject to separate transcriptional regulatory programs, including distinct transcription factor (TF) proteins that significantly favor lncRNA, rather than coding-gene, promoters. We report a specific signature of promoter-proximal transcriptional regulation of lncRNA genes, including several distinct transcription factor binding sites (TFBS). Experimental DNase I hypersensitive site profiles are consistent with active configurations of these lncRNA TFBS sets in diverse human cell types. TFBS ChIP-seq datasets confirm the binding events that we predicted using computational approaches for a subset of factors. For several TFs known to be directly regulated by lncRNAs, we find that their putative TFBSs are enriched at lncRNA promoters, suggesting that the TFs and the lncRNAs may participate in a bidirectional feedback loop regulatory network. Accordingly, cells may be able to modulate lncRNA expression levels independently of mRNA levels via distinct regulatory pathways. Our results also raise the possibility that, given the historical reliance on protein-coding gene catalogs to define the chromatin states of active promoters, a revision of these chromatin signature profiles to incorporate expressed lncRNA genes is warranted in the future.

  19. Development of building security integration system using sensors, microcontroller and GPS (Global Positioning System) based android smartphone

    Science.gov (United States)

    Sihombing, P.; Siregar, Y. M.; Tarigan, J. T.; Jaya, I.; Turnip, A.

    2018-03-01

    Security system is one of the common problems to protect an environment such as personal house or a warehouse. There are numerous methods and technologies that can be used as part of a security system. In this paper, we present a security system that offers a better efficiency. The purpose of this study is to build a system that can monitor home security at any time in particular fire and theft. Through sensors, the system will be able to provide warning information of hazard conditions via LCD monitor, sound, and alarm. This information will be sent automatically to the home owner’s smartphone as well as to the corresponding to the security agency. Thus the prevention of theft and fire hazards can be immediately anticipated by the police and firefighters. The system will also notify the position of the coordinates of the location of the building (the house) by a link to the Google map in order to make it easier to get the location quickly.

  20. Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria.

    Science.gov (United States)

    Hedengren-Olcott, Marika; Olcott, Michael C; Mooney, Duane T; Ekengren, Sophia; Geller, Bruce L; Taylor, Barbara J

    2004-05-14

    The current model of immune activation in Drosophila melanogaster suggests that fungi and Gram-positive (G(+)) bacteria activate the Toll/Dif pathway and that Gram-negative (G(-)) bacteria activate the Imd/Relish pathway. To test this model, we examined the response of Relish and Dif (Dorsal-related immunity factor) mutants to challenge by various fungi and G(+) and G(-) bacteria. In Relish mutants, the Cecropin A gene was induced by the G(+) bacteria Micrococcus luteus and Staphylococcus aureus, but not by other G(+) or G(-) bacteria. This Relish-independent Cecropin A induction was blocked in Dif/Relish double mutant flies. Induction of the Cecropin A1 gene by M. luteus required Relish, whereas induction of the Cecropin A2 gene required Dif. Intact peptidoglycan (PG) was necessary for this differential induction of Cecropin A. PG extracted from M. luteus induced Cecropin A in Relish mutants, whereas PGs from the G(+) bacteria Bacillus megaterium and Bacillus subtilis did not, suggesting that the Drosophila immune system can distinguish PGs from various G(+) bacteria. Various fungi stimulated antimicrobial peptides through at least two different pathways requiring Relish and/or Dif. Induction of Attacin A by Geotrichum candidum required Relish, whereas activation by Beauvaria bassiana required Dif, suggesting that the Drosophila immune system can distinguish between at least these two fungi. We conclude that the Drosophila immune system is more complex than the current model. We propose a new model to account for this immune system complexity, incorporating distinct pattern recognition receptors of the Drosophila immune system, which can distinguish between various fungi and G(+) bacteria, thereby leading to selective induction of antimicrobial peptides via differential activation of Relish and Dif.

  1. Patterns of accentuated grey-white differentiation on diffusion-weighted imaging or the apparent diffusion coefficient maps in comatose survivors after global brain injury

    International Nuclear Information System (INIS)

    Kim, E.; Sohn, C.-H.; Chang, K.-H.; Chang, H.-W.; Lee, D.H.

    2011-01-01

    Aim: To determine what disease entities show accentuated grey-white differentiation of the cerebral hemisphere on diffusion-weighted images (DWI) or apparent diffusion coefficient (ADC) maps, and whether there is a correlation between the different patterns and the cause of the brain injury. Methods and materials: The DWI and ADC maps of 19 patients with global brain injury were reviewed and evaluated to investigate whether there was a correlation between the different patterns seen on the DWI and ADC maps and the cause of global brain injury. The ADC values were measured for quantitative analysis. Results: There were three different patterns of ADC decrease: a predominant ADC decrease in only the cerebral cortex (n = 8; pattern I); an ADC decrease in both the cerebral cortex and white matter (WM) and a predominant decrease in the WM (n = 9; pattern II); and a predominant ADC decrease in only the WM (n = 3; pattern III). Conclusion: Pattern I is cerebral cortical injury, suggesting cortical laminar necrosis in hypoxic brain injury. Pattern II is cerebral cortical and WM injury, frequently seen in brain death, while pattern 3 is mainly WM injury, especially found in hypoglycaemic brain injury. It is likely that pattern I is decorticate injury and pattern II is decerebrate injury in hypoxic ischaemic encephalopathy.Patterns I and II are found in severe hypoxic brain injury, and pattern II is frequently shown in brain death, whereas pattern III was found in severe hypoglycaemic injury.

  2. Global Gene-Expression Analysis to Identify Differentially Expressed Genes Critical for the Heat Stress Response in Brassica rapa.

    Directory of Open Access Journals (Sweden)

    Xiangshu Dong

    Full Text Available Genome-wide dissection of the heat stress response (HSR is necessary to overcome problems in crop production caused by global warming. To identify HSR genes, we profiled gene expression in two Chinese cabbage inbred lines with different thermotolerances, Chiifu and Kenshin. Many genes exhibited >2-fold changes in expression upon exposure to 0.5- 4 h at 45°C (high temperature, HT: 5.2% (2,142 genes in Chiifu and 3.7% (1,535 genes in Kenshin. The most enriched GO (Gene Ontology items included 'response to heat', 'response to reactive oxygen species (ROS', 'response to temperature stimulus', 'response to abiotic stimulus', and 'MAPKKK cascade'. In both lines, the genes most highly induced by HT encoded small heat shock proteins (Hsps and heat shock factor (Hsf-like proteins such as HsfB2A (Bra029292, whereas high-molecular weight Hsps were constitutively expressed. Other upstream HSR components were also up-regulated: ROS-scavenging genes like glutathione peroxidase 2 (BrGPX2, Bra022853, protein kinases, and phosphatases. Among heat stress (HS marker genes in Arabidopsis, only exportin 1A (XPO1A (Bra008580, Bra006382 can be applied to B. rapa for basal thermotolerance (BT and short-term acquired thermotolerance (SAT gene. CYP707A3 (Bra025083, Bra021965, which is involved in the dehydration response in Arabidopsis, was associated with membrane leakage in both lines following HS. Although many transcription factors (TF genes, including DREB2A (Bra005852, were involved in HS tolerance in both lines, Bra024224 (MYB41 and Bra021735 (a bZIP/AIR1 [Anthocyanin-Impaired-Response-1] were specific to Kenshin. Several candidate TFs involved in thermotolerance were confirmed as HSR genes by real-time PCR, and these assignments were further supported by promoter analysis. Although some of our findings are similar to those obtained using other plant species, clear differences in Brassica rapa reveal a distinct HSR in this species. Our data could also provide a

  3. Standardized radiologic protocol for the study of common coccygodynia and characteristics of the lesions observed in the sitting position. Clinical elements differentiating luxation, hypermobility, and normal mobility.

    Science.gov (United States)

    Maigne, J Y; Tamalet, B

    1996-11-15

    Ninety-one patients with common coccygodynia and 47 control subjects prospectively underwent dynamic radiographic imagery. To standardize the radiologic protocol to better define normal and abnormal mobility of the coccyx, and to study clinical parameters useful in classifying and differentiating the lesions. In a previous study, comparison of films taken in the sitting and standing positions allowed to individualize two distinct coccygeal lesions: luxation and hypermobility. Measurement technique was precise and reproducible, but the control group was not pain-free. No specific clinical features were described. Standing films were made first. Control subjects were healthy volunteers. The following items were recorded: presence of an initial traumatic event, elapsed time before investigation, body mass index, presence of an acute pain when passing from sitting to standing, effect of intradiscal steroid injection, and angle of the coccyx with respect to the seat. Hypermobility was defined as a flexion of more than 25 degrees, luxation by displacement of more than 25% of the coccyx. The base angle is a good predictor of the direction in which the coccyx moves when sitting. In the "luxation" group, a history of initial trauma, a shorter clinical course, pain when standing up, increased body mass index, and satisfactory results with intradiscal injection were found more frequently than in the "normal" group. The "hypermobility" group had characteristics between these two groups. Common coccygodynia is associated in 48.4% of patients with a luxation or hypermobility of the coccyx. A distinct clinical presentation was found in individuals with luxation of the coccyx.

  4. Differential selection on carotenoid biosynthesis genes as a function of gene position in the metabolic pathway: a study on the carrot and dicots.

    Directory of Open Access Journals (Sweden)

    Jérémy Clotault

    Full Text Available Selection of genes involved in metabolic pathways could target them differently depending on the position of genes in the pathway and on their role in controlling metabolic fluxes. This hypothesis was tested in the carotenoid biosynthesis pathway using population genetics and phylogenetics.Evolutionary rates of seven genes distributed along the carotenoid biosynthesis pathway, IPI, PDS, CRTISO, LCYB, LCYE, CHXE and ZEP, were compared in seven dicot taxa. A survey of deviations from neutrality expectations at these genes was also undertaken in cultivated carrot (Daucus carota subsp. sativus, a species that has been intensely bred for carotenoid pattern diversification in its root during its cultivation history. Parts of sequences of these genes were obtained from 46 individuals representing a wide diversity of cultivated carrots. Downstream genes exhibited higher deviations from neutral expectations than upstream genes. Comparisons of synonymous and nonsynonymous substitution rates between genes among dicots revealed greater constraints on upstream genes than on downstream genes. An excess of intermediate frequency polymorphisms, high nucleotide diversity and/or high differentiation of CRTISO, LCYB1 and LCYE in cultivated carrot suggest that balancing selection may have targeted genes acting centrally in the pathway.Our results are consistent with relaxed constraints on downstream genes and selection targeting the central enzymes of the carotenoid biosynthesis pathway during carrot breeding history.

  5. A Decade of Global mRNA and miRNA Profiling of HPV-Positive Cell Lines and Clinical Specimens

    DEFF Research Database (Denmark)

    Kaczkowski, Bogumil; Morevati, Marya; Rossing, Maria

    2012-01-01

    For more than a decade, global gene expression profiling has been extensively used to elucidate the biology of human papillomaviruses (HPV) and their role in cervical- and head-and-neck cancers. Since 2008, the expression profiling of miRNAs has been reported in multiple HPV studies. Two major...... strategies have been employed in the gene and miRNA profiling studies: In the first approach, HPV positive tumors were compared to normal tissues or to HPV negative tumors. The second strategy relied on analysis of cell cultures transfected with single HPV oncogenes or with HPV genomes compared...... as the fragmented miRNA-mRNA target correlation evidence. Furthermore, we propose an approach for future research to include more comprehensive miRNA-mRNA target correlation analysis and to apply systems biology/gene networks methodology....

  6. Differentially Private Distributed Sensing

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Glenn A.

    2016-12-11

    The growth of the Internet of Things (IoT) creates the possibility of decentralized systems of sensing and actuation, potentially on a global scale. IoT devices connected to cloud networks can offer Sensing and Actuation as a Service (SAaaS) enabling networks of sensors to grow to a global scale. But extremely large sensor networks can violate privacy, especially in the case where IoT devices are mobile and connected directly to the behaviors of people. The thesis of this paper is that by adapting differential privacy (adding statistically appropriate noise to query results) to groups of geographically distributed sensors privacy could be maintained without ever sending all values up to a central curator and without compromising the overall accuracy of the data collected. This paper outlines such a scheme and performs an analysis of differential privacy techniques adapted to edge computing in a simulated sensor network where ground truth is known. The positive and negative outcomes of employing differential privacy in distributed networks of devices are discussed and a brief research agenda is presented.

  7. Differentially expressed genes during spontaneous lytic switch of Marek's disease virus in lymphoblastoid cell lines determined by global gene expression profiling.

    Science.gov (United States)

    Mwangi, William N; Vasoya, Deepali; Kgosana, Lydia B; Watson, Mick; Nair, Venugopal

    2017-04-01

    Marek's disease virus (MDV), an alphaherpesvirus of poultry, causes Marek's disease and is characterized by visceral CD4+TCRαβ+ T-cell lymphomas in susceptible hosts. Immortal cell lines harbouring the viral genome have been generated from ex vivo cultures of MD tumours. As readily available sources of large numbers of cells, MDV-transformed lymphoblastoid cell lines (LCLs) are extremely valuable for studies of virus-host interaction. While the viral genome in most cells is held in a latent state, minor populations of cells display spontaneous reactivation identifiable by the expression of lytic viral genes. Spontaneous reactivation in these cells presents an opportunity to investigate the biological processes involved in the virus reactivation. For detailed characterization of the molecular events associated with reactivation, we used two lymphoblastoid cell lines derived from lymphomas induced by pRB1B-UL47eGFP, a recombinant MDV engineered to express enhanced green fluorescent protein (EGFP) fused with the UL47. We used fluorescence-activated cell sorting to purify the low-frequency EGFP-positive cells with a spontaneously activating viral genome from the majority EGFP-negative cells and analysed their gene expression profiles by RNA-seq using Illumina HiSeq2500. Ingenuity pathway analysis on more than 2000 differentially expressed genes between the lytically infected (EGFP-positive) and latently infected (EGFP-negative) cell populations identified the biological pathways involved in the reactivation. Virus-reactivating cells exhibited differential expression of a significant number of viral genes, with hierarchical differences in expression levels. Downregulation of a number of host genes including those directly involved in T-cell activation, such as CD3, CD28, ICOS and phospholipase C, was also noticed in the LCL undergoing lytic switch.

  8. Expression of Hepcidin and Growth Differentiation Factor 15 (GDF-15 Levels in Thalassemia Patients with Iron Overload and Positive Anti Hepatitis C Virus

    Directory of Open Access Journals (Sweden)

    Nuri Dyah Indrasari

    2016-09-01

    Full Text Available Background: Thalassemia patients who undergo life-long recurrent blood transfusion will experience iron overload in various organs including the liver and possibly suffer from chronic hepatitis C infection which may lead to liver impairment. The liver produces hepcidin, a hormone which plays role in the regulation of iron level in the blood. Various factors may influence hepcidin level in the blood. Chronic hepatitis C causes iron overload and liver impairment. Liver impairment and haemolytic anaemia due to haemoglobinopathy will suppress hepcidin production. Anaemia stimulates growth differentiation factor 15 (GDF-15 to increase erythropoiesis and suppress hepcidin production. Iron overload causes increase in hepcidin level. Presence of factors which decrease or increase hepcidin production will express various levels of hepcidin. This study aimed to identify the expression of hepcidin and GDF-15 levels in thalassemia patients with iron overload and positive anti-HCV. Information on hepcidin and GDF-15 levels are beneficial in the management of iron overload in thalassemia with positive anti-HCV. Method: This study was a descriptive analytic study in thalassemia patients who had received recurrent blood transfusion ≥ 12 times, suffered from iron overload (transferrin saturation > 55% and ferritin > 1,000 ng/mL, which consisted of 31 individuals with positive anti-HCV and 27 individuals with negative anti-HCV. This study was performed in Thalassemia Centre Department of Child Health and Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, in October 2011–January 2012. Serum hepcidin and GDF-15 examinations were performed using enzyme-linked immunosorbent assay (ELISA method. Aspartate aminotransferase (AST and alanine aminotransferase (ALT examinations were performed using colorimetry method. Data on ferritin and transferrin saturation were obtained from medical records in the last 3

  9. Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression

    Energy Technology Data Exchange (ETDEWEB)

    Li, Luchuan; Lv, Bin; Chen, Bo [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Guan, Ming [Department of General Surgery, Qihe People' s Hospital, Qihe, Shandong 251100 (China); Sun, Yongfeng [Department of General Surgery, Licheng District People' s Hospital, Jinan, Shandong 250115 (China); Li, Haipeng [Department of General Surgery, Caoxian People' s Hospital, Caoxian, Shandong 274400 (China); Zhang, Binbin; Ding, Changyuan; He, Shan [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Zeng, Qingdong, E-mail: qingdz0201@163.com [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China)

    2015-07-10

    Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the role of miRNAs in RAIU has not been generally investigated. Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. The top candidate miR-146b, with the most significant overexpression profiles in dedifferentiated cells, was picked up. Further research found that miR-146b could be negatively regulated by histone deacetylase 3 (HDAC3) in normal cells, indicating the correlation between miR-146b and Na{sup +}/I{sup −} symporter (NIS)-mediated RAIU. Fortunately, it was confirmed that miR-146b could regulate NIS expression/activity; what is more important, miR-146b interference would contribute to the recovery of radioiodine-sensitivity in dedifferentiated cells via positively regulating NIS. In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). - Highlights: • Significant upregulated miR-146b was picked up from thyroid relative miRNAs in DTC. • MiR-146b was negatively regulated by HDAC3 in normal thyroid carcinoma cells. • NIS activity and expression could be regulated by miR-146b in thyroid carcinoma. • MiR-146b inhibition could recover the decreased radioiodine-sensitivity of DTC cells.

  10. Differential regulation of polysaccharide-specific antibody responses to isolated polysaccharides, conjugate vaccines, and intact Gram-positive versus Gram-negative extracellular bacteria.

    Science.gov (United States)

    Snapper, Clifford M

    2016-06-24

    Bacterial capsular polysaccharides are major virulence factors and are key targets in a number of licensed anti-bacterial vaccines. Their major characteristics are their large molecular weight and expression of repeating antigenic epitopes that mediate multivalent B cell receptor cross-linking. In addition, since the majority of these antigens cannot associate with MHC-II they fail to recruit CD4+ T cell help and are referred to as T cell-independent antigens. In this review I will discuss a series of studies from my laboratory that have underscored the importance of understanding polysaccharide-specific antibody responses within the context in which the PS is expressed (i.e. in isolation, as a component of conjugate vaccines, and expressed naturally by intact bacteria). We have shown that multivalent B cell receptor crosslinking, as mediated by polysaccharides, uniquely determines the qualitative response of the B cell to subsequent stimuli, but by itself is insufficient to induce antibody secretion or class switching. For these latter events to occur, second signals must act in concert with primary signals derived from the B cell receptor. The co-expression of polysaccharide and protein within intact bacteria promotes recruitment of CD4+ T cell help for the associated PS-specific IgG response, in contrast to isolated polysaccharides. Further, the particulate nature of extracellular bacteria confers properties to the polysaccharide-specific IgG response that makes it distinct immunologically from soluble conjugate vaccines. Finally, the underlying biochemical and/or structural differences that distinguish Gram-positive and Gram-negative bacteria appear to play critical roles in differentially regulating the associated polysaccharide-specific IgG responses to these groups of pathogens. These studies have a number of implications for the understanding and future design of polysaccharide-based vaccines. Published by Elsevier Ltd.

  11. Nuclear Positioning

    Science.gov (United States)

    Gundersen, Gregg G.; Worman, Howard J.

    2013-01-01

    SUMMARY The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways. PMID:23498944

  12. Differential climate impacts for policy-relevant limits to global warming: the case of 1.5 °C and 2 °C

    Science.gov (United States)

    Schleussner, Carl-Friedrich; Lissner, Tabea K.; Fischer, Erich M.; Wohland, Jan; Perrette, Mahé; Golly, Antonius; Rogelj, Joeri; Childers, Katelin; Schewe, Jacob; Frieler, Katja; Mengel, Matthias; Hare, William; Schaeffer, Michiel

    2016-04-01

    agricultural yields differ between crop types as well as world regions. While some (in particular high-latitude) regions may benefit, tropical regions like West Africa, South-East Asia, as well as Central and northern South America are projected to face substantial local yield reductions, particularly for wheat and maize. Best estimate sea-level rise projections based on two illustrative scenarios indicate a 50 cm rise by 2100 relative to year 2000-levels for a 2 °C scenario, and about 10 cm lower levels for a 1.5 °C scenario. In a 1.5 °C scenario, the rate of sea-level rise in 2100 would be reduced by about 30 % compared to a 2 °C scenario. Our findings highlight the importance of regional differentiation to assess both future climate risks and different vulnerabilities to incremental increases in global-mean temperature. The article provides a consistent and comprehensive assessment of existing projections and a good basis for future work on refining our understanding of the difference between impacts at 1.5 °C and 2 °C warming.

  13. Estimation and analysis of the short-term variations of multi-GNSS receiver differential code biases using global ionosphere maps

    Science.gov (United States)

    Li, Min; Yuan, Yunbin; Wang, Ningbo; Liu, Teng; Chen, Yongchang

    2017-12-01

    Care should be taken to minimize the adverse impact of differential code biases (DCBs) on global navigation satellite systems (GNSS)-derived ionospheric information determinations. For the sake of convenience, satellite and receiver DCB products provided by the International GNSS Service (IGS) are treated as constants over a period of 24 h (Li et al. (2014)). However, if DCB estimates show remarkable intra-day variability, the DCBs estimated as constants over 1-day period will partially account for ionospheric modeling error; in this case DCBs will be required to be estimated over shorter time period. Therefore, it is important to further gain insight into the short-term variation characteristics of receiver DCBs. In this contribution, the IGS combined global ionospheric maps and the German Aerospace Center (DLR)-provided satellite DCBs are used in the improved method to determine the multi-GNSS receiver DCBs with an hourly time resolution. The intra-day stability of the receiver DCBs is thereby analyzed in detail. Based on 1 month of data collected within the multi-GNSS experiment of the IGS, a good agreement within the receiver DCBs is found between the resulting receiver DCB estimates and multi-GNSS DCB products from the DLR at a level of 0.24 ns for GPS, 0.28 ns for GLONASS, 0.28 ns for BDS, and 0.30 ns for Galileo. Although most of the receiver DCBs are relatively stable over a 1-day period, large fluctuations (more than 9 ns between two consecutive hours) within the receiver DCBs can be found. We also demonstrate the impact of the significant short-term variations in receiver DCBs on the extraction of ionospheric total electron content (TEC), at a level of 12.96 TECu (TEC unit). Compared to daily receiver DCB estimates, the hourly DCB estimates obtained from this study can reflect the short-term variations of the DCB estimates more dedicatedly. The main conclusion is that preliminary analysis of characteristics of receiver DCB variations over short

  14. Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers.

    Science.gov (United States)

    Seto, Edmund Y W; Sousa-Figueiredo, José C; Betson, Martha; Byalero, Chris; Kabatereine, Narcis B; Stothard, J Russell

    2012-11-01

    The establishment of a national control programme (NCP) in Uganda has led to routine treatment of intestinal schistosomiasis with praziquantel in the communities along Lake Albert. However, because regular water contact remains a way of life for these populations, re-infection continues to mitigate the sustainability of the chemotherapy-based programme. A six-month longitudinal study was conducted in one Lake Albert community with the aim of characterizing water contact exposure and infection among mothers and their young preschool-aged children as the latter are not yet formally included within the NCP. At baseline the cohort of 37 mothers, 36 preschool-aged children had infection prevalences of 62% and 67%, respectively, which diminished to 20% and 29%, respectively, at the 6-month post-treatment follow-up. The subjects wore global positioning system (GPS) datalogging devices over a 3-day period shortly after baseline, allowing for the estimation of time spent at the lakeshore as an exposure metric, which was found to be associated with prevalence at follow-up (OR = 2.1, P = 0.01 for both mothers and young children and odds ratio (OR) = 4.4, P = 0.01 for young children alone). A social network of interpersonal interactions was also derived from the GPS data, and the exposures were positively associated both with the number and duration of peer interaction, suggesting the importance of socio-cultural factors associated with water contact behaviour. The findings illustrate reduction in both prevalence and intensity of infection in this community after treatment as well as remarkably high rates of water contact exposure and re-infection, particularly among younger children. We believe that this should now be formally considered within NCP, which may benefit from more in-depth ethnographic exploration of factors related to water contact as this should provide new opportunities for sustaining control.

  15. Global skeletal uptake of technetium-99m methylene diphosphonate in female patients receiving suppressive doses of L-thyroxine for differentiated thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Frusciante, V.; Dicembrino, F. [Department of Nuclear Medicine, Ospedale ``Casa Sollievo della Sofferenza``, IRCCS di San Giovanni Rotondo (Italy); Carnevale, V. [Division of Internal Medicine, Ospedale ``Casa Sollievo della Sofferenza``, IRCCS di San Giovanni Rotondo (Italy); Scillitani, A.; Zingrillo, M.; Ghiggi, M.R. [Division of Endocrinology, Ospedale ``Casa Sollievo della Sofferenza``, IRCCS di San Giovanni Rotondo (Italy); Giannatempo, G.M. [Department of Radiology, Ospedale ``Casa Sollievo della Sofferenza``, IRCCS di San Giovanni Rotondo (Italy); Minisola, S. [Istituto di II Clinica Medica, Universita degli Studi di Roma ``La Sapienza``, Rome (Italy)

    1998-02-01

    This study was carried out in order to investigate the possible detrimental effects on bone of levothyroxine (l-T{sub 4}) suppressive therapy in female patients who had undergone surgery for differentiated thyroid cancer (DTC). Twenty female (14 premenopausal and 6 postmenopausal) patients receiving l-T{sub 4} suppressive therapy for DTC were studied. The sample was selected in such a way as to avoid factors influencing bone metabolism other than l-T{sub 4}. All patients were monitored by sensitive thyroid-stimulating hormone, free triiodothyronine and free thyroxine assays throughout the follow-up. Nineteen healthy (12 premenopausal and 7 postmenopausal) matched women served as controls. In all subjects bone turnover was evaluated by the measurement of global skeletal uptake of technetium-99m methylene diphosphonate (GSU); bone mineral density (BMD) was measured by quantitative computed tomography at the lumbar spine (LS) and by dual-energy X-ray absorptiometry both at the LS and at three femoral sites: the femoral neck, Ward`s triangle and the greater trochanter. No significant difference was found in either GSU or BMD between patients (treated for an average period of 68 months) and controls in the whole sample or in any subgroup. Furthermore, no correlations were found between either GSU or BMD and the duration of therapy, daily doses of l-T{sub 4} or results of thyroid function tests. Our data show that carefully monitored l-T{sub 4} therapy does not influence skeletal turnover (directly reflected by GSU) or the bone density of the spine and femur. (orig.) With 1 fig., 2 tabs., 36 refs.

  16. Hha controls Escherichia coli O157:H7 biofilm formation by differential regulation of global transcriptional regulators FlhDC and CsgD.

    Science.gov (United States)

    Sharma, Vijay K; Bearson, Bradley L

    2013-04-01

    Although molecular mechanisms promoting adherence of enterohemorrhagic Escherichia coli (EHEC) O157:H7 on epithelial cells are well characterized, regulatory mechanisms controlling biofilm formation are not fully understood. In this study, we demonstrate that biofilm formation in EHEC O157:H7 strain 86-24 is highly repressed compared to that in an isogenic hha mutant. The hha mutant produced large quantities of biofilm compared to the wild-type strain at 30°C and 37°C. Complementation of the hha mutant reduced the level of biofilm formation to that of the wild-type strain, indicating that Hha is a negative regulator of biofilm production. While swimming motility and expression of the flagellar gene fliC were significantly reduced, the expression of csgA (encoding curlin of curli fimbriae) and the ability to bind Congo red were significantly enhanced. The expression of both fliC and csgA and the phenotypes of motility and curli production affected by these two genes, respectively, were restored to wild-type levels in the complemented hha mutant. The csgA deletion abolished biofilm formation in the hha mutant and wild-type strain, and csgA complementation restored biofilm formation to these strains, indicating the importance of csgA and curli in biofilm formation. The regulatory effects of Hha on flagellar and curli gene expression appear to occur via the induction and repression of FlhDC and CsgD, as demonstrated by reduced flhD and increased csgD transcription in the hha mutant, respectively. In gel shift assays Hha interacted with flhDC and csgD promoters. In conclusion, Hha regulates biofilm formation in EHEC O157:H7 by differential regulation of FlhDC and CsgD, the global regulators of motility and curli production, respectively.

  17. Differences in Spatial Physical Activity Patterns between Weekdays and Weekends in Primary School Children: A Cross-Sectional Study Using Accelerometry and Global Positioning System

    Directory of Open Access Journals (Sweden)

    Rahel Bürgi

    2016-06-01

    Full Text Available Targeting the weekend to promote physical activity (PA in children seems to be promising given that they tend to be less physically active and, particularly, as the age-related decline in PA is more marked during weekends. Considering the ambiguity of why children are not able to maintain their PA level on weekends, the aim of the present study was to objectively investigate differences in children’s spatial PA patterns between week and weekend days using the combination of Global Positioning System (GPS and accelerometry. Seventy-four second graders (aged 7–9 years and 98 sixth graders (aged 11–14 years wore an accelerometer and GPS sensor for seven consecutive days to determine where children spend time and engage in PA. Time-matched accelerometer and GPS data was mapped with a geographic information system and multilevel analyses accounting for the hierarchical structure of the data were conducted. Differences between weekdays and weekends regarding the total time spent and the absolute and relative level of PA in various settings were found in both age groups. The findings support previous research pointing to the importance of targeting weekend PA, especially when children grow older. Future interventions should encourage children to use outdoor spaces more frequently on weekends, rather than stay at home, and to commute actively to destinations other than school.

  18. Investigation of land subsidence in the Houston-Galveston region of Texas by using the Global Positioning System and interferometric synthetic aperture radar, 1993-2000

    Science.gov (United States)

    Bawden, Gerald W.; Johnson, Michaela R.; Kasmarek, Mark C.; Brandt, Justin; Middleton, Clifton S.

    2012-01-01

    Since the early 1900s, groundwater has been the primary source of municipal, industrial, and agricultural water supplies for the Houston-Galveston region, Texas. The region's combination of hydrogeology and nearly century-long use of groundwater has resulted in one of the largest areas of subsidence in the United States; by 1979, as much as 3 meters (m) of subsidence had occurred, and approximately 8,300 square kilometers of land had subsided more than 0.3 m. The U.S. Geological Survey, in cooperation with the Harris-Galveston Subsidence District, used interferometric synthetic aperture radar (InSAR) data obtained for four overlapping scenes from European remote sensing satellites ERS-1 and ERS-2 to analyze land subsidence in the Houston-Galveston region of Texas. The InSAR data were processed into 27 interferograms that delineate and quantify land-subsidence patterns and magnitudes. Contemporaneous data from the Global Positioning System (GPS) were reprocessed by the National Geodetic Survey and analyzed to support, verify, and provide temporal resolution to the InSAR investigation.

  19. Applying the global positioning system and google earth to evaluate the accessibility of birth services for pregnant women in northern Malawi.

    Science.gov (United States)

    Chen, Solomon Chih-Cheng; Wang, Jung-Der; Yu, Joseph Kwong-Leung; Rn, Tzu-Yi Chiang; Chan, Chang-Chuan; Rn, Hsiu-Hung Wang; Nyasulu, Yohane M Z; Kolola-Dzimadzi, Rose

    2011-01-01

    The objective of this study was to validate the combined use of the Global Positioning System (GPS) and Google Earth for measuring the accessibility of health care facilities for pregnant women in northern Malawi. We used GPS and Google Earth to identify 5 major health care facilities in Mzuzu (Malawi) and the homes of 79 traditional birth attendants (TBAs). The distance and time required for each TBA to reach the nearest health care facility were measured by both GPS and by self-report of the TBAs. A convenience sample of 1138 pregnant women was interviewed about their choices of birth sites for current and previous pregnancies and the time and cost required to access health care facilities. The correlation coefficient between the objective measurements by GPS and subjective reports by TBAs for time required from their homes to health care facilities was 0.654 (P birth at a health care facility. However, only 48.7% of women actually gave birth in a health care facility in a previous pregnancy, and 32.6% were assisted by TBAs. Combined GPS and Google Earth can be useful in the evaluation of accessibility of health care facilities, especially for emergency obstetric care. © 2011 by the American College of Nurse-Midwives.

  20. Global positioning system measurements of ground deformation caused by magma intrusion and lava discharge: the 1990 1995 eruption at Unzendake volcano, Kyushu, Japan

    Science.gov (United States)

    Nishi, K.; Ono, H.; Mori, H.

    1999-04-01

    Global positioning system (GPS) measurements made around Unzendake volcano, Kyushu, Japan, since January 1991 have detected ground deformation caused by magma intrusion and lava discharge. In the intermittent phreatic and phreatomagmatic eruption stage, the ground was inflating. After growth of the lava dome and following frequent pyroclastic flows at Unzendake volcano, the ground began deflating. These ground deformations are explained by the inflation and deflation of a Mogi's source model (a point source model) located about 6 km west of the active crater at a depth of 11 km, at an aseismic region. The observed horizontal displacement vectors pointed radially away from the estimated pressure source during inflation and pointed to the pressure source during deflation. The horizontal displacements at the reference GPS station calculated from contraction of the estimated pressure source coincide well with the actual horizontal displacements observed from other GPS baseline systems. These observations validate our estimates for the pressure source. Based on the relation between the deformation volume of the ground surface and the discharged volume of the lava, it is estimated that during the eruption there was magma supply from the deeper portion as well as magma discharge at the crater. Magma is estimated to be supplied to the reservoir at an average rate of 1.1×10 5 m 3/day; magma intrusion began in December 1989 at the latest and continued for 1.9×10 3 days.

  1. Concurrent validity and test-retest reliability of a global positioning system (GPS) and timing gates to assess sprint performance variables.

    Science.gov (United States)

    Waldron, Mark; Worsfold, Paul; Twist, Craig; Lamb, Kevin

    2011-12-01

    There has been no previous investigation of the concurrent validity and reliability of the current 5 Hz global positioning system (GPS) to assess sprinting speed or the reliability of integrated GPS-accelerometer technology. In the present study, we wished to determine: (1) the concurrent validity and reliability of a GPS and timing gates to measure sprinting speed or distance, and (2) the reliability of proper accelerations recorded via GPS-accelerometer integration. Nineteen elite youth rugby league players performed two over-ground sprints and were simultaneously assessed using GPS and timing gates. The GPS measurements systematically underestimated both distance and timing gate speed. The GPS measurements were reliable for all variables of distance and speed (coefficient of variation [CV] = 1.62% to 2.3%), particularly peak speed (95% limits of agreement [LOA] = 0.00 ± 0.8 km · h(-1); CV = 0.78%). Timing gates were more reliable (CV = 1% to 1.54%) than equivalent GPS measurements. Accelerometer measurements were least reliable (CV = 4.69% to 5.16%), particularly for the frequency of proper accelerations (95% LOA = 1.00 ± 5.43; CV = 14.12%). Timing gates and GPS were found to reliably assess speed and distance, although the validity of the GPS remains questionable. The error found in accelerometer measurements indicates the limits of this device for detecting changes in performance.

  2. Assessing worst case scenarios in movement demands derived from global positioning systems during international rugby union matches: Rolling averages versus fixed length epochs

    Science.gov (United States)

    Cunningham, Daniel J.; Shearer, David A.; Carter, Neil; Drawer, Scott; Pollard, Ben; Bennett, Mark; Eager, Robin; Cook, Christian J.; Farrell, John; Russell, Mark

    2018-01-01

    The assessment of competitive movement demands in team sports has traditionally relied upon global positioning system (GPS) analyses presented as fixed-time epochs (e.g., 5–40 min). More recently, presenting game data as a rolling average has become prevalent due to concerns over a loss of sampling resolution associated with the windowing of data over fixed periods. Accordingly, this study compared rolling average (ROLL) and fixed-time (FIXED) epochs for quantifying the peak movement demands of international rugby union match-play as a function of playing position. Elite players from three different squads (n = 119) were monitored using 10 Hz GPS during 36 matches played in the 2014–2017 seasons. Players categorised broadly as forwards and backs, and then by positional sub-group (FR: front row, SR: second row, BR: back row, HB: half back, MF: midfield, B3: back three) were monitored during match-play for peak values of high-speed running (>5 m·s-1; HSR) and relative distance covered (m·min-1) over 60–300 s using two types of sample-epoch (ROLL, FIXED). Irrespective of the method used, as the epoch length increased, values for the intensity of running actions decreased (e.g., For the backs using the ROLL method, distance covered decreased from 177.4 ± 20.6 m·min-1 in the 60 s epoch to 107.5 ± 13.3 m·min-1 for the 300 s epoch). For the team as a whole, and irrespective of position, estimates of fixed effects indicated significant between-method differences across all time-points for both relative distance covered and HSR. Movement demands were underestimated consistently by FIXED versus ROLL with differences being most pronounced using 60 s epochs (95% CI HSR: -6.05 to -4.70 m·min-1, 95% CI distance: -18.45 to -16.43 m·min-1). For all HSR time epochs except one, all backs groups increased more (p < 0.01) from FIXED to ROLL than the forward groups. Linear mixed modelling of ROLL data highlighted that for HSR (except 60 s epoch), SR was the only group not

  3. Fault model of the 2017 Jiuzhaigou Mw 6.5 earthquake estimated from coseismic deformation observed using Global Positioning System and Interferometric Synthetic Aperture Radar data

    Science.gov (United States)

    Nie, Zhaosheng; Wang, Di-Jin; Jia, Zhige; Yu, Pengfei; Li, Liangfa

    2018-04-01

    On August 8, 2017, the Jiuzhaigou Mw 6.5 earthquake occurred in Sichuan province, southwestern China, along the eastern margin of the Tibetan Plateau. The epicenter is surrounded by the Minjiang, Huya, and Tazang Faults. As the seismic activity and tectonics are very complicated, there is controversy regarding the accurate location of the epicenter and the seismic fault of the Jiuzhaigou earthquake. To investigate these aspects, first, the coseismic deformation field was derived from Global Positioning System (GPS) and Interferometric Synthetic Aperture Radar (InSAR) measurements. Second, the fault geometry, coseismic slip model, and Coulomb stress changes around the seismic region were calculated using a homogeneous elastic half-space model. The coseismic deformation field derived from InSAR measurements shows that this event was mainly dominated by a left-lateral strike-slip fault. The maximal and minimal displacements were approximately 0.15 m and - 0.21 m, respectively, along line-of-sight observation. The whole deformation field follows a northwest-trending direction and is mainly concentrated west of the fault. The coseismic slip is 28 km along the strike and 18 km along the dip. It is dominated by a left-lateral strike-slip fault. The average and maximal fault slip is 0.18 and 0.85 m, respectively. The rupture did not fully reach the ground surface. The focal mechanism derived from GPS and InSAR data is consistent with the kinematics and geometry of the Huya Fault. Therefore, we conclude that the northern section or the Shuzheng segment of the Huya Fault is the seismogenic fault. The maximal fault slip is located at 33.25°N and 103.82°E at a depth of 11 km, and the release moment is approximately 6.635 × 1018 Nm, corresponding to a magnitude of Mw 6.49, which is consistent with results reported by the US Geological Survey, Global Centroid Moment Tensor, and other researchers. The coseismic Coulomb stress changes enhanced the stress on the northwest and

  4. Upregulated microRNA-92b regulates the differentiation and proliferation of EpCAM-positive fetal liver cells by targeting C/EBPß.

    Directory of Open Access Journals (Sweden)

    Nian-Song Qian

    Full Text Available microRNAs (miRNAs are short noncoding RNAs that negatively regulate gene expression. Although recent evidences have been indicated that their aberrant expression may play an important role in cancer stem cells, the mechanism of their deregulation in neoplastic transformation of liver cancer stem cells (LCSCs has not been explored. In our study, the HCC model was established in F344 rats by DEN induction. The EpCAM(+ cells were sorted out from unfractionated fetal liver cells and liver cancer cells using the FACS analysis and miRNA expression profiles of two groups were screened through microarray platform. Gain-of-function studies were performed in vitro and in vivo to determine the role of miR-92b on proliferation and differentiation of the hepatic progenitors. In addition, luciferase reporter system and gene function analysis were used to predict miR-92b target. we found that miR-92b was highly downregulated in EpCAM(+ fetal liver cells in expression profiling studies. RT-PCR analysis demonstrated reverse correlation between miR-92b expression and differentiation degree in human HCC samples. Overexpression of miR-92b in EpCAM(+ fetal liver cells significantly increased proliferation and inhibited differentiation as well as in vitro and in vivo studies. Moreover, we verified that C/EBPß is a direct target of miR-92b and contributes to its effects on proliferation and differentiation. We conclude that aberrant expression of miR-92b can result in proliferation increase and differentiation arrest of hepatic progenitors by targeting C/EBPß.

  5. Detection and measurement of land subsidence using interferometric synthetic aperture radar and Global Positioning System, San Bernardino County, Mojave Desert, California

    Science.gov (United States)

    Sneed, Michelle; Ikehara, Marti E.; Stork, Sylvia V.; Amelung, Falk; Galloway, Devin L.

    2003-01-01

    Land subsidence associated with ground-water-level declines has been recognized as a potential problem in parts of the Mojave Desert, California. Ground water has been the primary source of domestic, agricultural, and municipal water supplies in the desert since the early 1900s. Pumping of ground water from the Mojave River and Morongo ground-water basins in the southwestern Mojave Desert resulted in water-level declines of more than 30 meters (100 feet) between the 1950s and the 1990s. A Global Positioning System (GPS) survey of a geodetic network was used to determine the location, extent, and magnitude of vertical land-surface changes in Lucerne Valley in the Morongo ground-water basin. The GPS survey was conducted in 1998 to estimate historical elevation changes by comparing GPS-derived elevations with historical elevations (which were available for some of the monuments in the network as early as 1944) and to establish baseline values that can be used for comparisons with future GPS surveys. The GPS measurements indicated that about 600 millimeters (2 feet) [plus or minus 1,500 millimeters (5 feet)] of subsidence occurred at three of the monuments between 1969 and 1998 but that very little to no vertical change in position occurred at seven other monuments in the network. Water levels in the area of subsidence in Lucerne Valley declined about 15 meters (50 feet) during 1970-98. Interferometric synthetic aperture radar (InSAR) methods were used to characterize vertical land-surface changes in the Mojave River and Morongo ground-water basins during various intervals of time between 1992 and 1999. Interferograms, InSAR-generated displacement maps, show that subsidence ranging from 45 to 90 mm (0.15 to 0.3 ft) occurred in four areas of these two ground-water basins--the El Mirage, Lockhart-Harper Lake (dry), Newberry Springs, and Lucerne Valley areas. Some of the InSAR measurements were affected by the earthquakes at Landers and Hector Mine, California, and by

  6. Using Global Positioning Systems (GPS) and temperature data to generate time-activity classifications for estimating personal exposure in air monitoring studies: an automated method.

    Science.gov (United States)

    Nethery, Elizabeth; Mallach, Gary; Rainham, Daniel; Goldberg, Mark S; Wheeler, Amanda J

    2014-05-08

    Personal exposure studies of air pollution generally use self-reported diaries to capture individuals' time-activity data. Enhancements in the accuracy, size, memory and battery life of personal Global Positioning Systems (GPS) units have allowed for higher resolution tracking of study participants' locations. Improved time-activity classifications combined with personal continuous air pollution sampling can improve assessments of location-related air pollution exposures for health studies. Data was collected using a GPS and personal temperature from 54 children with asthma living in Montreal, Canada, who participated in a 10-day personal air pollution exposure study. A method was developed that incorporated personal temperature data and then matched a participant's position against available spatial data (i.e., road networks) to generate time-activity categories. The diary-based and GPS-generated time-activity categories were compared and combined with continuous personal PM2.5 data to assess the impact of exposure misclassification when using diary-based methods. There was good agreement between the automated method and the diary method; however, the automated method (means: outdoors = 5.1%, indoors other =9.8%) estimated less time spent in some locations compared to the diary method (outdoors = 6.7%, indoors other = 14.4%). Agreement statistics (AC1 = 0.778) suggest 'good' agreement between methods over all location categories. However, location categories (Outdoors and Transit) where less time is spent show greater disagreement: e.g., mean time "Indoors Other" using the time-activity diary was 14.4% compared to 9.8% using the automated method. While mean daily time "In Transit" was relatively consistent between the methods, the mean daily exposure to PM2.5 while "In Transit" was 15.9 μg/m3 using the automated method compared to 6.8 μg/m3 using the daily diary. Mean times spent in different locations as categorized by a GPS-based method were

  7. The use of Global Positioning System units and ArcGIS Online to engage K-12 Students in Research Being Done in their Local Communities

    Science.gov (United States)

    Butcher, C. E.; Sparrow, E. B.; Clucas, T.

    2015-12-01

    Incorporating K-12 students in scientific research processes and opportunities in their communities is a great way to bridge the gap between research and education and to start building science research capacity at an early age. One goal of the Experimental Program to Stimulate Competitive Research (EPSCoR) Alaska Adapting to Changing Environments project is to engage the local community in the research as well as to share results with the people. By giving K-12 students Global Positioning System (GPS) units, and allowing them to collect and map their own data, they are being exposed to some of the research methods being used by scientists in the Alaska ACE project. This hands-on, minds-on method has been successfully used in formal education settings such as a Junior High School classroom in Nuiqsut, Alaska as well as in informal education settings such as summer camps in Barrow, Alaska and Kenai, Alaska. The students progress from mapping by hand to collecting location data with their GPS units and cameras, and imputing this information into ArcGIS Online to create map products. The data collected were from sites ranging from important places in the community to sites visited during summer camps, with students reflecting on data and site significance. Collecting data, using technology, and creating map products contribute to science skills and practices students need to conduct research of their own and to understand research being done around them. The goal of this education outreach implementation is to bring students closer to the research, understand the process of science, and have the students continue to collect data and contribute to research in their communities. Support provided for this work from the Alaska EPSCoR NSF Award #OIA-1208927 and the state of Alaska is gratefully acknowledged.

  8. The validity and reliability of a global positioning satellite system device to assess speed and repeated sprint ability (RSA) in athletes.

    Science.gov (United States)

    Barbero-Alvarez, José C; Coutts, Aaron; Granda, Juan; Barbero-Alvarez, Verónica; Castagna, Carlo

    2010-03-01

    There is a limited understanding of the validity and reliability of commercially available global positioning satellite (GPS) devices for assessing repeated sprint performance in athletes. The aims of this study were to assess the convergent validity and the test-retest reliability of a GPS device for measuring repeated sprint ability test (RSAT) variables. Two groups participated in this study, a group of 21 physical education students (age: 20.2+/-2.3 years, stature: 1.75+/-0.42 m, body mass: 68.0+/-6.8kg) and a second group 14 elite junior soccer players (age: 14.5+/-1.2 years, stature: 1.60+/-0.09 m, body mass: 57.7+/-3.8kg) volunteered to participate in this study. Convergent validity was assessed as the correlation between sprint performance (15 and 30-m) using both timing lights and a portable GPS device during a RSAT (7 x 30-m sprints with 30-s of active recovery). The 7 x 30-m RSAT test-retest reliability using GPS device was assessed in elite junior soccer players repeating the test 1 week apart and expressing reliability as a coefficient of variation. Results showed a strong correlation between peak speed measures with the GPS device and RSAT performance measured with timing lights for the 15-m (r(2)=0.87, p<0.001, N=147) and 30-m (r(2)=0.94, p<0.001, N=147) splits, respectively. There was a low coefficient of variation for summated maximal speed (1.7%) and peak speed (1.2%) during the 7 x 30-m RSAT, but high variation for the percentage decrement score (36.2%). These results provide evidence to support the use of the GPS device as an alternative measure to assess repeated sprint performance but suggest a percentage decrement score is not a reliable measure of RSAT performance. Copyright 2009 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  9. CAN WE PREDICT THE GLOBAL MAGNETIC TOPOLOGY OF A PRE-MAIN-SEQUENCE STAR FROM ITS POSITION IN THE HERTZSPRUNG–RUSSELL DIAGRAM?

    International Nuclear Information System (INIS)

    Gregory, S. G.; Hillenbrand, L. A.; Donati, J.-F.; Morin, J.; Hussain, G. A. J.; Mayne, N. J.; Jardine, M.

    2012-01-01

    Zeeman-Doppler imaging studies have shown that the magnetic fields of T Tauri stars can be significantly more complex than a simple dipole and can vary markedly between sources. We collect and summarize the magnetic field topology information obtained to date and present Hertzsprung-Russell (H-R) diagrams for the stars in the sample. Intriguingly, the large-scale field topology of a given pre-main-sequence (PMS) star is strongly dependent upon the stellar internal structure, with the strength of the dipole component of its multipolar magnetic field decaying rapidly with the development of a radiative core. Using the observational data as a basis, we argue that the general characteristics of the global magnetic field of a PMS star can be determined from its position in the H-R diagram. Moving from hotter and more luminous to cooler and less luminous stars across the PMS of the H-R diagram, we present evidence for four distinct magnetic topology regimes. Stars with large radiative cores, empirically estimated to be those with a core mass in excess of ∼40% of the stellar mass, host highly complex and dominantly non-axisymmetric magnetic fields, while those with smaller radiative cores host axisymmetric fields with field modes of higher order than the dipole dominant (typically, but not always, the octupole). Fully convective stars above ∼> 0.5 M ☉ appear to host dominantly axisymmetric fields with strong (kilo-Gauss) dipole components. Based on similarities between the magnetic properties of PMS stars and main-sequence M-dwarfs with similar internal structures, we speculate that a bistable dynamo process operates for lower mass stars (∼ ☉ at an age of a few Myr) and that they will be found to host a variety of magnetic field topologies. If the magnetic topology trends across the H-R diagram are confirmed, they may provide a new method of constraining PMS stellar evolution models.

  10. Using accelerometers and global positioning system devices to assess gender and age differences in children’s school, transport, leisure and home based physical activity

    Science.gov (United States)

    2014-01-01

    Background Knowledge on domain-specific physical activity (PA) has the potential to advance public health interventions and inform new policies promoting children’s PA. The purpose of this study is to identify and assess domains (leisure, school, transport, home) and subdomains (e.g., recess, playgrounds, and urban green space) for week day moderate to vigorous PA (MVPA) using objective measures and investigate gender and age differences. Methods Participants included 367 Danish children and adolescents (11–16 years, 52% girls) with combined accelerometer and Global Positioning System (GPS) data (mean 2.5 days, 12.7 hrs/day). The Personal Activity and Location Measurement System and a purpose-built database assessed data in 15-second epochs to determine PA and assign epochs to 4 domains and 11 subdomains. Frequencies and proportions of time spent in MVPA were determined and differences assessed using multi-level modeling. Results More than 90% of MVPA was objectively assigned to domains/subdomains. Boys accumulated more MVPA overall, in leisure, school and transport (all p sports facilities, urban green space and school grounds. Girls spent a significant proportion of time accumulating MVPA in active transport and playgrounds. No gender or age differences were found in the home domain. Conclusions Large variations were found in PA frequency and intensity across domains/subdomains. Significant gender differences were found, with girls being less active in almost all domains and subdomains. Objectively measured patterns of PA across domains/subdomains can be used to better tailor PA interventions and inform future policies for promoting child PA. PMID:24457029

  11. Global Positioning System constraints on crustal deformation before and during the 21 February 2008 Wells, Nevada M6.0 earthquake

    Science.gov (United States)

    Hammond, William C.; Blewitt, Geoffrey; Kreemer, Corné; Murray-Moraleda, Jessica R.; Svarc, Jerry L.; dePolo, Craig M.; LaPointe, Daphne D.

    2011-01-01

    Using Global Positioning System (GPS) data from permanent sites and U.S. Geological Survey (USGS) campaign data we have estimated co-seismic displacements and secular background crustal deformation patterns associated with the 21 February 2008 Wells Nevada earthquake. Estimated displacements at nearby permanent GPS sites ELKO (84 km distant) and GOSH (81 km distant) are 1.0±0.2 mm and 1.1±0.3 mm, respectively. The magnitude and direction are in agreement with those predicted from a rupture model based on InSAR measurements of the near-field co-seismic surface displacement. Analysis of long GPS time series (>10 years) from the permanent sites within 250 km of the epicenter indicate the eastern Nevada Basin and Range undergoes steady tectonic transtension with rates on the order of 1 mm/year over approximately 250 km. The azimuth of maximum horizontal crustal extension is consistent with the azimuth of the Wells earthquake co-seismic slip vector. The orientation of crustal shear is consistent with deformation associated with Pacific/North America plate boundary relative motion seen elsewhere in the Basin and Range. In response to the event, we deployed a new GPS site with the capability to telemeter high rate, low latency data that will in the future allow for rapid estimation of surface displacement should aftershocks or postseismic deformations occur. We estimated co-seismic displacements using campaign GPS data collected before and after the event, however in most cases their uncertainties were larger than the offsets. Better precision in co-seismic displacement could have been achieved for the campaign sites if they had been surveyed more times or over a longer interval to better estimate their pre-event velocity.

  12. Evaluation of global differential gene and protein expression in primary Pterygium: S100A8 and S100A9 as possible drivers of a signaling network.

    Directory of Open Access Journals (Sweden)

    Aihua Hou

    Full Text Available PURPOSE: Pterygium is a wing shaped fibrovascular growth on the ocular surface, characterized by fibrosis, angiogenesis, extracellular matrix remodeling, and inflammatory infiltrates. Epidemiologic studies have linked pterygium formation to various chronic inflammatory conditions, such as ultraviolet radiation, sawdust exposure, and dry eye disease. The purpose of this study is to identify proteins that are differentially expressed in primary pterygium by using a combination of gene microarray and proteomic platforms. METHODS: Paired pterygium and uninvolved conjunctiva tissues of four patients were evaluated for differences in global gene transcript levels using a genechip microarray. Proteins extracted from another four pairs of tissues were quantified by iTRAQ approach. Western blot and immunofluorescent staining on additional patients were used to validate dysregulated protein expression obtained from microarray and proteomics data. In addition, primary conjunctival fibroblasts were treated with recombinant S100A8, S100A9 or both. Transcript level changes of a panel of potential target genes were evaluated by real time-PCR. RESULTS: The following were up-regulated at both protein and transcript levels S100 A8 and A9, aldehyde dehydrogenase 3 family, member1 (ALDH3A1 and vimentin (VIM. Conversely, serpin peptidase inhibitor clade A member 1 (SERPINA1 and transferrin (TF were down-regulated. Upon adding S100A8, S100A9 or both, the inflammatory chemokine CXCL1, matrix proteins vimentin, biglycan, and gelsolin, as well as annexin-A2, thymosin-β4, chymase (CMA1, member of Ras oncogene family RAB10 and SERPINA1 were found to be up-regulated. CONCLUSIONS: We identified 3 up-regulated and 2 down-regulated proteins by using a stringent approach comparing microarray and proteomic data. On stimulating cells with S100A8/9, a repertoire of key genes found to be up-regulated in pterygium tissue, were induced in these cells. S100A8/9 may be an upstream

  13. Understanding the position of end nodes in the world city network: using peer city analysis to differentiate between non-hub cities

    NARCIS (Netherlands)

    Mans, U.

    2014-01-01

    In the current debate on the world city network and inter-city connectivity, a large number of cities, particularly in developing countries, have received limited attention. Despite a growing interest in emerging market cities, many scholars still focus on the more affluent parts of the global

  14. Recent topics in differential and analytic geometry

    CERN Document Server

    Ochiai, T

    1990-01-01

    Advanced Studies in Pure Mathematics, Volume 18-I: Recent Topics in Differential and Analytic Geometry presents the developments in the field of analytical and differential geometry. This book provides some generalities about bounded symmetric domains.Organized into two parts encompassing 12 chapters, this volume begins with an overview of harmonic mappings and holomorphic foliations. This text then discusses the global structures of a compact Kähler manifold that is locally decomposable as an isometric product of Ricci-positive, Ricci-negative, and Ricci-flat parts. Other chapters con

  15. Spatial physical activity patterns among primary school children living in neighbourhoods of varying socioeconomic status: a cross-sectional study using accelerometry and Global Positioning System

    Directory of Open Access Journals (Sweden)

    Rahel Bürgi

    2016-03-01

    Full Text Available Abstract Background Neighbourhood socioeconomic status (SES has been shown to be related to health status and overweight independent of individual SES. However, results about the association between neighbourhood SES and physical activity among children are ambiguous. Particularly, it is unknown how socioeconomic factors influence the spatial context of children’s moderate-vigorous physical activity (MVPA and sedentary behaviour (SB. This study aimed to investigate by means of Global Positioning System (GPS and accelerometry whether locations where children engage in MVPA and SB differ by neighbourhood SES. Methods Participants included 83 children aged 7–9 from nine public schools located in a low- and high-SES area in Zurich, Switzerland. Children wore an accelerometer and GPS sensor for seven consecutive days. Time-matched accelerometer and GPS data was mapped with a geographic information system and each data point assigned to one of eight activity settings. The amount and proportion of MVPA and SB were calculated for every setting. To investigate differences between the two SES groups, multilevel analyses accounting for the hierarchical structure of the data were conducted. Results Both SES groups achieved most minutes in MVPA at own school, on streets and at home and recorded the highest proportions of MVPA in recreational facilities, streets and other schools. The highest amounts and proportions of SB were found at home and own school. High-SES children accumulated significantly more minutes in MVPA and SB in parks, sport facilities, other schools and streets, while the low-SES group spent more time in both activities in other places. When taking the total time spent in a setting into account and using the proportion of MVPA or SB, the only differences between the two groups were found at other schools and outside, where the high-SES children showed a significantly higher activity level (p-values <0.001. Conclusions Several

  16. Timing of warm water refuge use in Crystal River National Wildlife Refuge by manatees—Results and insights from Global Positioning System telemetry data

    Science.gov (United States)

    Slone, Daniel H.; Butler, Susan M.; Reid, James P.; Haase, Catherine G.

    2017-11-21

    Managers at the U.S. Fish and Wildlife Service Crystal River National Wildlife Refuge (CRNWR) desire to update their management plan regarding the operation of select springs including Three Sisters Springs. They wish to refine existing parameters used to predict the presence of federally threatened Trichechus manatus latirostris (Florida manatee) in the springs and thereby improve their manatee management options. The U.S. Geological Survey Sirenia Project has been tracking manatees in the CRNWR area since 2006 with floating Global Positioning System (GPS) satellite-monitored telemetry tags. Analyzing movements of these tagged manatees will provide valuable insight into their habitat use patterns.A total of 136 GPS telemetry bouts were available for this project, representing 730,009 locations generated from 40 manatees tagged in the Gulf of Mexico north of Tampa, Florida. Dates from October through March were included to correspond to the times that cold ambient temperatures were expected, thus requiring a need for manatee thermoregulation and a physiologic need for warm water. Water level (tide) and water temperatures were obtained for the study from Salt River, Crystal River mouth, Bagley Cove, Kings Bay mouth, and Magnolia Spring. Polygons were drawn to subdivide the manatee locations into areas around the most-used springs (Three Sisters/Idiots Delight, House/Hunter/Jurassic, Magnolia and King), Kings Bay, Crystal/Salt Rivers and the Gulf of Mexico.Manatees were found in the Crystal or Salt Rivers or in the Gulf of Mexico when ambient temperatures were warmer (>20 °C), while they were found in or near the springs (especially Three Sisters Springs) at colder ambient water temperatures. There was a trend of manatees entering springs early in the morning and leaving in the afternoon. There was a strong association of manatee movements in and out of the Three Sisters/Idiots Delight polygon with tide cycles: manatees were more likely to enter the Three Sisters

  17. Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli.

    Science.gov (United States)

    Ihara, Kohei; Sato, Kazuki; Hori, Hatsuhiro; Makino, Yumiko; Shigenobu, Shuji; Ando, Tasuke; Isogai, Emiko; Yoneyama, Hiroshi

    2017-04-01

    The alaE gene in Escherichia coli encodes an l-alanine exporter that catalyzes the active export of l-alanine using proton electrochemical potential. In our previous study, alaE expression was shown to increase in the presence of l-alanyl-l-alanine (Ala-Ala). In this study, the global regulator leucine-responsive regulatory protein (Lrp) was identified as an activator of the alaE gene. A promoter less β-galactosidase gene was fused to an alaE upstream region (240 nucleotides). Cells that were lacZ-deficient and harbored this reporter plasmid showed significant induction of β-galactosidase activity (approximately 17-fold) in the presence of 6 mM l-alanine, l-leucine, and Ala-Ala. However, a reporter plasmid possessing a smaller alaE upstream region (180 nucleotides) yielded transformants with strikingly low enzyme activity under the same conditions. In contrast, lrp-deficient cells showed almost no β-galactosidase induction, indicating that Lrp positively regulates alaE expression. We next performed an electrophoretic mobility shift assay (EMSA) and a DNase I footprinting assay using purified hexahistidine-tagged Lrp (Lrp-His). Consequently, we found that Lrp-His binds to the alaE upstream region spanning nucleotide -161 to -83 with a physiologically relevant affinity (apparent K D , 288.7 ± 83.8 nM). Furthermore, the binding affinity of Lrp-His toward its cis-element was increased by l-alanine and l-leucine, but not by Ala-Ala and d-alanine. Based on these results, we concluded that the gene expression of the alaE is regulated by Lrp in response to intracellular levels of l-alanine, which eventually leads to intracellular homeostasis of l-alanine concentrations. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  18. Perceived spatial stigma, body mass index and blood pressure: a global positioning system study among low-income housing residents in New York City

    Directory of Open Access Journals (Sweden)

    Dustin T. Duncan

    2016-05-01

    Full Text Available Previous research has highlighted the salience of spatial stigma on the lives of low-income residents, but has been theoretical in nature and/or has predominantly utilised qualitative methods with limited generalisability and ability to draw associations between spatial stigma and measured cardiovascular health outcomes. The primary objective of this study was to evaluate relationships between perceived spatial stigma, body mass index (BMI, and blood pressure among a sample of low-income housing residents in New York City (NYC. Data come from the community-based NYC Low-income Housing, Neighborhoods and Health Study. We completed a crosssectional analysis with survey data, which included the four items on spatial stigma, as well objectively measured BMI and blood pressure data (analytic n=116; 96.7% of the total sample. Global positioning systems (GPS tracking of the sample was conducted for a week. In multivariable models (controlling for individual-level age, gender, race/ethnicity, education level, employment status, total household income, neighborhood percent non-Hispanic Black and neighborhood median household income we found that participants who reported living in an area with a bad neighborhood reputation had higher BMI (B=4.2, 95%CI: -0.01, 8.3, P=0.051, as well as higher systolic blood pressure (B=13.2, 95%CI: 3.2, 23.1, P=0.01 and diastolic blood pressure (B=8.5, 95%CI: 2.8, 14.3, P=0.004. In addition, participants who reported living in an area with a bad neighborhood reputation had increased risk of obesity/overweight [relative risk (RR=1.32, 95%CI: 1.1, 1.4, P=0.02 and hypertension/pre-hypertension (RR=1.66, 95%CI: 1.2, 2.4, P=0.007. However, we found no differences in spatial mobility (based GPS data among participants who reported living in neighborhoods with and without spatial stigma (P>0.05. Further research is needed to investigate how placebased stigma may be associated with impaired cardiovascular health among individuals

  19. Traits across the personality hierarchy differentially relate to positive and negative affect: Evidence for the predictive validity of empirically derived meta-traits.

    Science.gov (United States)

    Hengartner, Michael P; Graf, Markus; Schreiber, Marc

    2017-05-01

    There is increasing interest in the construct validity of higher-order domains of the Big Five personality traits. A total of 831 persons from the Swiss population completed the International Personality Item Pool and an adaptation of the Positive and Negative Affect Scales. Using Goldberg's bass-ackwards method, we found evidence for the general factor of personality (GFP) and the two meta-traits of positive emotionality (blend of low neuroticism and high extraversion) and constraint (blend of high agreeableness and conscientiousness). In association with positive affect, the explanatory power of the GFP (r = 0.43) and positive emotionality (r = 0.37) was largely superior to extraversion (r = 0.24), conscientiousness (r = 0.18), agreeableness (r = 0.09) and openness (r = 0.04), although not neuroticism (r = -0.34). In association with negative affect, neuroticism (r = 0.41), the GFP (r = -0.36) and positive emotionality (r = -0.35) were the most powerful single predictors. We conclude that the higher-order structure of personality is best explained by the meta-traits of positive emotionality and constraint, which correspond closely to the well-established superfactors of internalizing and externalizing. We further demonstrate that these have substantial criterion validity when broad positive and negative affect is the outcome of interest. These findings help to relate Big Five meta-traits to pathological personality. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  20. Gene expression analysis of PTEN positive glioblastoma stem cells identifies DUB3 and Wee1 modulation in a cell differentiation model.

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    Stefano Forte

    Full Text Available The term astrocytoma defines a quite heterogeneous group of neoplastic diseases that collectively represent the most frequent brain tumors in humans. Among them, glioblastoma multiforme represents the most malignant form and its associated prognosis is one of the poorest among tumors of the central nervous system. It has been demonstrated that a small population of tumor cells, isolated from the brain neoplastic tissue, can reproduce the parental tumor when transplanted in immunodeficient mouse. These tumor initiating cells are supposed to be involved in cancer development and progression and possess stem cell-like features; like their normal counterpart, these cells remain quiescent until they are committed to differentiation. Many studies have shown that the role of the tumor suppressor protein PTEN in cell cycle progression is fundamental for tumor dynamics: in low grade gliomas, PTEN contributes to maintain cells in G1 while the loss of its activity is frequently observed in high grade gliomas. The mechanisms underlying the above described PTEN activity have been studied in many tumors, but those involved in the maintenance of tumor initiating cells quiescence remain to be investigated in more detail. The aim of the present study is to shed light on the role of PTEN pathway on cell cycle regulation in Glioblastoma stem cells, through a cell differentiation model. Our results suggest the existence of a molecular mechanism, that involves DUB3 and WEE1 gene products in the regulation of Cdc25a, as functional effector of the PTEN/Akt pathway.