WorldWideScience

Sample records for diagnostics timing integration

  1. SNS Diagnostics Timing Integration

    CERN Document Server

    Long, Cary D; Murphy, Darryl J; Pogge, James; Purcell, John D; Sundaram, Madhan

    2005-01-01

    The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based running Windows XP Embedded for its OS and LabVIEW as its programming language. Coordinating timing among the various diagnostics instruments with the generation of the beam pulse is a challenging task that we have chosen to divide into three phases. First, timing was derived from VME based systems. In the second phase, described in this paper, timing pulses are generated by an in house designed PCI timing card installed in ten diagnostics PCs. Using fan-out modules, enough triggers were generated for all instruments. This paper describes how the Timing NAD (Network Attached Device) was rapidly developed using our NAD template, LabVIEW's PCI driver wizard, and LabVIEW Channel Access library. The NAD...

  2. An integrated real-time diagnostic concept using expert systems, qualitative reasoning and quantitative analysis

    International Nuclear Information System (INIS)

    Edwards, R.M.; Lee, K.Y.; Kumara, S.; Levine, S.H.

    1989-01-01

    An approach for an integrated real-time diagnostic system is being developed for inclusion as an integral part of a power plant automatic control system. In order to participate in control decisions and automatic closed loop operation, the diagnostic system must operate in real-time. Thus far, an expert system with real-time capabilities has been developed and installed on a subsystem at the Experimental Breeder Reactor (EBR-II) in Idaho, USA. Real-time simulation testing of advanced power plant concepts at the Pennsylvania State University has been developed and was used to support the expert system development and installation at EBR-II. Recently, the US National Science Foundation (NSF) and the US Department of Energy (DOE) have funded a Penn State research program to further enhance application of real-time diagnostic systems by pursuing implementation in a distributed power plant computer system including microprocessor based controllers. This paper summarizes past, current, planned, and possible future approaches to power plant diagnostic systems research at Penn State. 34 refs., 9 figs

  3. Video integrated measurement system. [Diagnostic display devices

    Energy Technology Data Exchange (ETDEWEB)

    Spector, B.; Eilbert, L.; Finando, S.; Fukuda, F.

    1982-06-01

    A Video Integrated Measurement (VIM) System is described which incorporates the use of various noninvasive diagnostic procedures (moire contourography, electromyography, posturometry, infrared thermography, etc.), used individually or in combination, for the evaluation of neuromusculoskeletal and other disorders and their management with biofeedback and other therapeutic procedures. The system provides for measuring individual diagnostic and therapeutic modes, or multiple modes by split screen superimposition, of real time (actual) images of the patient and idealized (ideal-normal) models on a video monitor, along with analog and digital data, graphics, color, and other transduced symbolic information. It is concluded that this system provides an innovative and efficient method by which the therapist and patient can interact in biofeedback training/learning processes and holds considerable promise for more effective measurement and treatment of a wide variety of physical and behavioral disorders.

  4. Integration of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in blood culture diagnostics: a fast and effective approach.

    Science.gov (United States)

    Klein, Sabrina; Zimmermann, Stefan; Köhler, Christine; Mischnik, Alexander; Alle, Werner; Bode, Konrad A

    2012-03-01

    Sepsis is a major cause of mortality in hospitalized patients worldwide, with lethality rates ranging from 30 to 70 %. Sepsis is caused by a variety of different pathogens, and rapid diagnosis is of outstanding importance, as early and adequate antimicrobial therapy correlates with positive clinical outcome. In recent years, matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) fingerprinting has become a powerful tool in microbiological diagnostics. The direct identification of micro-organisms in a positive blood culture by MALDI-TOF MS can shorten the diagnostic procedure significantly. Therefore, the aim of the present study was to evaluate whether identification rates could be improved by using the new Sepsityper kit from Bruker Daltonics for direct isolation and identification of bacteria from positive blood cultures by MALDI-TOF MS compared with the use of conventional separator gel columns, and to integrate the MALDI-TOF MS-based identification method into the routine course of blood culture diagnostics in the setting of a microbiological laboratory at a university hospital in Germany. The identification of Gram-negative bacteria by MALDI-TOF MS was significantly better using the Sepsityper kit compared with a separator gel tube-based method (99 and 68 % correct identification, respectively). For Gram-positive bacteria, only 73 % were correctly identified by MALDI-TOF with the Sepsityper kit and 59 % with the separator gel tube assay. A major problem of both methods was the poor identification of Gram-positive grape-like clustered cocci. As differentiation of Staphylococcus aureus from coagulase-negative staphylococci is of clinical importance, a PCR was additionally established that was capable of identifying S. aureus directly from positive blood cultures, thus closing this diagnostic gap. Another benefit of the PCR approach is the possibility of directly detecting the genes responsible for meticillin

  5. Integration of diagnostics into the ITER machine

    International Nuclear Information System (INIS)

    Janeschitz, G.; Walker, C.; Costley, A.

    2001-01-01

    This paper defines and discusses the integration of diagnostics systems into the ITER machine. For each machine region, the key constraints and solutions adopted are discussed, and illustrated with selected examples. (author)

  6. Automation, consolidation, and integration in autoimmune diagnostics.

    Science.gov (United States)

    Tozzoli, Renato; D'Aurizio, Federica; Villalta, Danilo; Bizzaro, Nicola

    2015-08-01

    Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, organizational changes have also occurred which brought about a more modern vision of the autoimmune laboratory. The introduction of automation (for harmonization of testing, reduction of human error, reduction of handling steps, increase of productivity, decrease of turnaround time, improvement of safety), consolidation (combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and integration (linking analytical instruments or group of instruments with pre- and post-analytical devices) opened a new era in immunodiagnostics. In this article, we review the most important changes that have occurred in autoimmune diagnostics and present some models related to the introduction of automation in the autoimmunology laboratory, such as automated indirect immunofluorescence and changes in the two-step strategy for detection of autoantibodies; automated monoplex immunoassays and reduction of turnaround time; and automated multiplex immunoassays for autoantibody profiling.

  7. NOVA integrated alignment/diagnostic sensors

    International Nuclear Information System (INIS)

    1978-01-01

    Under Contract 3772003 to the Lawrence Livermore Laboratory, Aerojet ElectroSystems Company has investigated a number of alignment system design topics for the NOVA and SHIVA upgrade lasers. Prior reports dealt with the Main Beam Alignment System, and with Multipass Amplifier Alignment Concepts. This report, which completes the contract, examines ways in which the Return Beam Diagnostic (RBD) package and Incident Beam Diagnostic (IBD) packages may be reconfigured to a more integrated package. In particular, the report shows that the RBD optics may be directly integrated in the Pointing Focus and Centering (PFC) sensor, and that the IBD optics may use the same basic common configuration as the PFC/RBD package

  8. Real time water chemistry monitoring and diagnostics

    International Nuclear Information System (INIS)

    Gaudreau, T.M.; Choi, S.S.

    2002-01-01

    EPRI has produced a real time water chemistry monitoring and diagnostic system. This system is called SMART ChemWorks and is based on the EPRI ChemWorks codes. System models, chemistry parameter relationships and diagnostic approaches from these codes are integrated with real time data collection, an intelligence engine and Internet technologies to allow for automated analysis of system chemistry. Significant data management capabilities are also included which allow the user to evaluate data and create automated reporting. Additional features have been added to the system in recent years including tracking and evaluation of primary chemistry as well as the calculation and tracking of primary to secondary leakage in PWRs. This system performs virtual sensing, identifies normal and upset conditions, and evaluates the consistency of on-line monitor and grab sample readings. The system also makes use of virtual fingerprinting to identify the cause of any chemistry upsets. This technology employs plant-specific data and models to determine the chemical state of the steam cycle. (authors)

  9. Diagnostic imaging in pregraduate integrated curricula

    International Nuclear Information System (INIS)

    Kainberger, F.; Kletter, K.

    2007-01-01

    Pregraduate medical curricula are currently undergoing a reform process that is moving away from a traditional discipline-related structure and towards problem-based integrated forms of teaching. Imaging sciences, with their inherently technical advances, are specifically influenced by the effects of paradigm shifts in medical education. The teaching of diagnostic radiology should be based on the definition of three core competencies: in vivo visualization of normal and abnormal morphology and function, diagnostic reasoning, and interventional treatment. On the basis of these goals, adequate teaching methods and e-learning tools should be implemented by focusing on case-based teaching. Teaching materials used in the fields of normal anatomy, pathology, and clinical diagnosis may help diagnostic radiology to play a central role in modern pregraduate curricula. (orig.)

  10. [Diagnostic imaging in pregraduate integrated curricula].

    Science.gov (United States)

    Kainberger, F; Kletter, K

    2007-11-01

    Pregraduate medical curricula are currently undergoing a reform process that is moving away from a traditional discipline-related structure and towards problem-based integrated forms of teaching. Imaging sciences, with their inherently technical advances, are specifically influenced by the effects of paradigm shifts in medical education. The teaching of diagnostic radiology should be based on the definition of three core competencies: in vivo visualization of normal and abnormal morphology and function, diagnostic reasoning, and interventional treatment. On the basis of these goals, adequate teaching methods and e-learning tools should be implemented by focusing on case-based teaching. Teaching materials used in the fields of normal anatomy, pathology, and clinical diagnosis may help diagnostic radiology to play a central role in modern pregraduate curricula.

  11. Modular initiator with integrated optical diagnostic

    Science.gov (United States)

    Alam, M Kathleen [Cedar Crest, NM; Schmitt, Randal L [Tijeras, NM; Welle, Eric J [Niceville, FL; Madden, Sean P [Arlington, MA

    2011-05-17

    A slapper detonator which integrally incorporates an optical wavequide structure for determining whether there has been degradation of the explosive in the explosive device that is to be initiated by the detonator. Embodiments of this invention take advantage of the barrel-like character of a typical slapper detonator design. The barrel assembly, being in direct contact with the energetic material, incorporates an optical diagnostic device into the barrel assembly whereby one can monitor the state of the explosive material. Such monitoring can be beneficial because the chemical degradation of the explosive plays an important in achieving proper functioning of a detonator/initiator device.

  12. Time-resolved x-ray diagnostics

    International Nuclear Information System (INIS)

    Lyons, P.B.

    1981-01-01

    Techniques for time-resolved x-ray diagnostics will be reviewed with emphasis on systems utilizing x-ray diodes or scintillators. System design concerns for high-bandwidth (> 1 GHz) diagnostics will be emphasized. The limitations of a coaxial cable system and a technique for equalizing to improve bandwidth of such a system will be reviewed. Characteristics of new multi-GHz amplifiers will be presented. An example of a complete operational system on the Los Alamos Helios laser will be presented which has a bandwidth near 3 GHz over 38 m of coax. The system includes the cable, an amplifier, an oscilloscope, and a digital camera readout

  13. Time response measurements of LASL diagnostic detectors

    International Nuclear Information System (INIS)

    Hocker, L.P.

    1970-07-01

    The measurement and data analysis techniques developed under the Los Alamos Scientific Laboratory's detector improvement program were used to characterize the time and frequency response of selected LASL Compton, fluor-photodiode (NPD), and fluor-photomultiplier (NPM) diagnostic detectors. Data acquisition procedures and analysis methods presently in use are summarized, and detector time and frequency data obtained using the EG and G/AEC electron linear accelerator fast pulse (approximately 50 psec FWHM) as the incident radiation driving function are presented. (U.S.)

  14. In times of Integration

    DEFF Research Database (Denmark)

    Val, Maria Rosa Rovira; Lehmann, Martin; Zinenko, Anna

    From late last century there has been a great development of international standards and tools on environment, sustainability and corporate responsibility issues. This has been along with the globalization of economy and politics, as well as a shift in the social responsibilities of the private vis...... procedures, such as cases of for example ISO integrated management systems, mutual equivalences recognition of Global Compact-GRI-ISO26000, or the case of IIRC initiative to develop integrated reporting on an organization’s Financial, Environmental, Social and Governance performance. This paper focuses......-a-vis the public sectors. Internationally, organisations have implemented a collection of these standards to be in line with such development and to obtain or keep their licence to operate globally. After two decades of development and maturation, the scenario is now different: (i) the economic context has changed...

  15. Integrated Artificial Intelligence Approaches for Disease Diagnostics.

    Science.gov (United States)

    Vashistha, Rajat; Chhabra, Deepak; Shukla, Pratyoosh

    2018-06-01

    Mechanocomputational techniques in conjunction with artificial intelligence (AI) are revolutionizing the interpretations of the crucial information from the medical data and converting it into optimized and organized information for diagnostics. It is possible due to valuable perfection in artificial intelligence, computer aided diagnostics, virtual assistant, robotic surgery, augmented reality and genome editing (based on AI) technologies. Such techniques are serving as the products for diagnosing emerging microbial or non microbial diseases. This article represents a combinatory approach of using such approaches and providing therapeutic solutions towards utilizing these techniques in disease diagnostics.

  16. Real time PV manufacturing diagnostic system

    Energy Technology Data Exchange (ETDEWEB)

    Kochergin, Vladimir [MicroXact Inc., Blacksburg, VA (United States); Crawford, Michael A. [MicroXact Inc., Blacksburg, VA (United States)

    2015-09-01

    The main obstacle Photovoltaic (PV) industry is facing at present is the higher cost of PV energy compared to that of fossil energy. While solar cell efficiencies continue to make incremental gains these improvements are so far insufficient to drive PV costs down to match that of fossil energy. Improved in-line diagnostics however, has the potential to significantly increase the productivity and reduce cost by improving the yield of the process. On this Phase I/Phase II SBIR project MicroXact developed and demonstrated at CIGS pilot manufacturing line a high-throughput in-line PV manufacturing diagnostic system, which was verified to provide fast and accurate data on the spatial uniformity of thickness, an composition of the thin films comprising the solar cell as the solar cell is processed reel-to-reel. In Phase II project MicroXact developed a stand-alone system prototype and demonstrated the following technical characteristics: 1) ability of real time defect/composition inconsistency detection over 60cm wide web at web speeds up to 3m/minute; 2) Better than 1mm spatial resolution on 60cm wide web; 3) an average better than 20nm spectral resolution resulting in more than sufficient sensitivity to composition imperfections (copper-rich and copper-poor regions were detected). The system was verified to be high vacuum compatible. Phase II results completely validated both technical and economic feasibility of the proposed concept. MicroXact’s solution is an enabling technique for in-line PV manufacturing diagnostics to increase the productivity of PV manufacturing lines and reduce the cost of solar energy, thus reducing the US dependency on foreign oil while simultaneously reducing emission of greenhouse gasses.

  17. An integrated stewardship model : Antimicrobial, infection prevention and diagnostic (AID)

    NARCIS (Netherlands)

    Dik, Jan-Willem H.; Poelman, Randy; Friedrich, Alexander W.; Panday, Prashant Nannan; Lo-Ten-Foe, Jerome R.; van Assen, Sander; van Gemert-Pijnen, Julia E. W. C.; Niesters, Hubert G. M.; Hendrix, Ron; Sinha, Bhanu

    2016-01-01

    Considering the threat of antimicrobial resistance and the difficulties it entails in treating infections, it is necessary to cross borders and approach infection management in an integrated, multidisciplinary manner. We propose the antimicrobial, infection prevention and diagnostic stewardship

  18. An integrated stewardship model: antimicrobial, infection prevention and diagnostic (AID)

    NARCIS (Netherlands)

    Dik, Jan-Willem H.; Poelman, Randy; Friedrich, Alexander W.; Panday, Prashant N.; Lo-Ten-Foe, Jerome R.; van Assen, Sander; van Gemert-Pijnen, Julia E.W.C.; Niesters, Hubert G.M.; Hendrix, Ron; Sinha, Bhanu

    2015-01-01

    Considering the threat of antimicrobial resistance and the difficulties it entails in treating infections, it is necessary to cross borders and approach infection management in an integrated, multidisciplinary manner. We propose the antimicrobial, infection prevention and diagnostic stewardship

  19. Process and overview of diagnostics integration in ITER ports

    International Nuclear Information System (INIS)

    Drevon, J.M.; Walsh, M.; Andrew, P.; Barnsley, R.; Bertalot, L.; Bock, M. de; Bora, D.; Bouhamou, R.; Direz, M.F.; Encheva, A.; Fang, T.; Feder, R.; Giacomin, T.; Hellermann, M. von; Jakhar, S.; Johnson, D.; Kaschuk, Y.; Kusama, Y.; Lee, H.G.; Levesy, B.

    2013-01-01

    Highlights: ► An overview of the Port Integration hardware for tenant system hosting inside ITER diagnostics ports is given. ► The main challenges for diagnostic port integration engineering are presented. ► The actions taken for a common modular approach and a coordinated design are detailed. -- Abstract: ITER will have a set of 45 diagnostics to ensure controlled operation. Many of them are integrated in the ITER ports. This paper addresses the integration process of the diagnostic systems and the approach taken to enable coordinated progress. An overview of the Port Integration hardware introduces the various structures needed for hosting tenant systems inside ITER diagnostics ports. The responsibilities of the different parties involved (ITER Organization and the Domestic Agencies) are outlined. The main challenges for diagnostic port integration engineering are summarized. The plan for a common approach to design and manufacture of the supporting structures, in particular the Port Plug is detailed. A coordinated design including common components and a common approach for neutronic analyses is proposed. One particular port, the equatorial port 11, is used to illustrate the approach

  20. Modification of the Integrated Sasang Constitutional Diagnostic Model

    Directory of Open Access Journals (Sweden)

    Jiho Nam

    2017-01-01

    Full Text Available In 2012, the Korea Institute of Oriental Medicine proposed an objective and comprehensive physical diagnostic model to address quantification problems in the existing Sasang constitutional diagnostic method. However, certain issues have been raised regarding a revision of the proposed diagnostic model. In this paper, we propose various methodological approaches to address the problems of the previous diagnostic model. Firstly, more useful variables are selected in each component. Secondly, the least absolute shrinkage and selection operator is used to reduce multicollinearity without the modification of explanatory variables. Thirdly, proportions of SC types and age are considered to construct individual diagnostic models and classify the training set and the test set for reflecting the characteristics of the entire dataset. Finally, an integrated model is constructed with explanatory variables of individual diagnosis models. The proposed integrated diagnostic model significantly improves the sensitivities for both the male SY type (36.4% → 62.0% and the female SE type (43.7% → 64.5%, which were areas of limitation of the previous integrated diagnostic model. The ideas of these new algorithms are expected to contribute not only to the scientific development of Sasang constitutional medicine in Korea but also to that of other diagnostic methods for traditional medicine.

  1. BIOTECHNICAL SYSTEM FOR INTEGRATED OLFACTOMETRY DIAGNOSTICS

    Directory of Open Access Journals (Sweden)

    Yana Nosova

    2017-09-01

    Full Text Available The subject matter of the article is the process of olfactometric research of a human olfactory function. The object of the study is a biotechnical system which includes a method for increasing the objectivity of olfactometric diagnostics. The goal is to develop a biotechnical system for complex olfactometry, which enables increasing the objectivity of olfactometric studies and connecting breathing parameters with olfactory function by placing an odorant carrier in the airway of the rhinomanometer, as well as by using procedures for determining the energy characteristics of respiration. The methods used are: methods of digital signal processing, the theory of biotechnical systems. The following results are obtained. A structural diagram of a biotechnical system for olfactometric diagnostics of a human olfactory analyser was developed. As a result of the analysis of the cyclogram of nasal breathing, it is found that by changing the frequency and nature of breathing upon reaching the sensitivity threshold, it is possible to objectify the method of assessing respiratory and olfactory disorders according to the energy criterion of pneumatic power when inhaling appropriate odorivectors, and also to study the olfactory and respiratory function with the capability of estimating respiratory cycles in a dynamic mode. The studies were carried out on the basis of typical inspiration cycles: with a quiet breathing in the normal conditions, in the forceful breathing mode with a stiff nasal valve, with a nasal valve with natural functional mobility which restricts the flow of air, and also a stepped inspiration – a short “sipping” of air, which can be characterized as a kind of “sniffing”. Conclusions. Computer olfactometry is one of the most promising methods for diagnosing olfactory disorders of respiratory genesis. The developed biotechnical system is based on the use of a fundamentally new design, combining a rhinomanometer and an olfactometric

  2. Design and integration of lower ports for ITER diagnostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Casal, Natalia, E-mail: Natalia.casal@iter.org [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Bertalot, Luciano; Cheng, Hao; Drevon, Jean Marc; Duckworth, Philip; Giacomin, Thibaud; Guirao, Julio; Iglesias, Silvia [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Kochergin, Mikhail [IOFFE Institute, Saint Petersburg (Russian Federation); Martin, Alex [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); McCarron, Eddie [Oxford Technologies Ltd., Abingdon (United Kingdom); Mokeev, Alexander [Russian Federation Domestic Agency, Moscow (Russian Federation); Mota, Fernando [CIEMAT, Madrid (Spain); Penot, Christophe; Portales, Mickael [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); Kitazawa, Sin-iti [Japanese Domestic Agency, Naka (Japan); Sky, Jack [Oxford Technologies Ltd., Abingdon (United Kingdom); Suarez, Alejandro; Udintsev, Victor; Utin, Yuri [ITER Organization, Route de Vinon-sur-Verdon – CS 90 046 – 13067 St Paul Lez Durance Cedex (France); and others

    2015-10-15

    Highlights: • Lower port structures are in its conceptual design phase. • Electromagnetic and seismic loads, will dominate all other mechanical loads. • Design allows diagnostics support, neutron shielding while and signals transmission. • Installation and maintenance operations are fully remote handling compatible. - Abstract: All around the ITER vacuum vessel, forty-four ports will provide access to the vacuum vessel for remote handling operations, diagnostic systems, heating, and vacuum systems: 18 upper ports, 17 equatorial ports, and 9 lower ports. Among the lower ports, three of them will be used for the remote handling installation of the ITER divertor. Once the divertor is in place, these ports will host various diagnostic systems mounted in the so-called diagnostic racks. The diagnostic racks must allow the support and cooling of the diagnostics, extraction of the required diagnostic signals, and providing access and maintainability while minimizing the leakage of radiation toward the back of the port where the humans are allowed to enter. A fully integrated inner rack, carrying the near plasma diagnostic components, will be an stainless steel structure, 4.2 m long, with a maximum weight of 10 t. This structure brings water for cooling and baking at maximum temperature of 240 °C and provides connection with gas, vacuum and electric services. Additional racks (placed away from plasma and not requiring cooling) may be required for the support of some particular diagnostic components. The diagnostics racks and its associated ex vessel structures, which are in its conceptual design phase, are being designed to survive the lifetime of ITER of 20 years. This paper presents the current state of development including interfaces, diagnostic integration, operation and maintenance, shielding requirements, remote handling, loads cases and discussion of the main challenges coming from the severe environment and engineering requirements.

  3. Integrated FASTBUS, VME and CAMAC diagnostic software at Fermilab

    International Nuclear Information System (INIS)

    Anderson, J.; Forster, R.; Franzen, J.; Wilcer, N.

    1992-10-01

    A fully integrated system for the diagnosis and repair of data acquisition hardware in FASTBUS, VME and CAMAC is described. A short cost/benefit analysis of using a distributed network of personal computers for diagnosis is presented. The SPUDS (Single Platform Uniting Diagnostic Software) software package developed at Fermilab by the authors is introduced. Examples of how SPUDS is currently used in the Fermilab equipment repair facility, as an evaluation tool and for field diagnostics are given

  4. Diagnostic integration solutions in the ITER first wall

    International Nuclear Information System (INIS)

    Martínez, Gonzalo; Martin, Alex; Watts, Christopher; Veshchev, Evgeny; Reichle, Roger; Shigin, Pavel; Sabourin, Flavien; Gicquel, Stefan; Mitteau, Raphael; González, Jorge

    2015-01-01

    Highlights: • This paper describes the current status of the integration efforts to implement diagnostics in the ITER first wall (FW). • Some diagnostics require a plasma facing element attached to the FW, commonly known as a FW diagnostic. Their design must comply not only with their functional requirements but also with the design of the blankets. • An integrated design concept has been developed. It provides a design that respects the requirements of each system. Thermo-mechanical analyses are on-going to confirm that this configuration respects the heat loads limits on the blanket FW. - Abstract: ITER will have about 50 diagnostic systems for machine protection, plasma control and optimization, and understanding the physics of burning plasma. The implementation in the ITER machine is challenging, particularly for the in-vessel diagnostics, region defined between the vacuum vessel and first wall (FW) contours, where space is constrained by the high number of systems. This paper describes the current status of design integration efforts to implement diagnostics in the ITER first wall. These approaches are the basis for detailed optimization and improvement of conceptual interfaces designs between systems.

  5. Diagnostic integration solutions in the ITER first wall

    Energy Technology Data Exchange (ETDEWEB)

    Martínez, Gonzalo, E-mail: gonzalo.martinez@iter.org [Technical University of Catalonia (UPC), Barcelona-Tech, Barcelona (Spain); Martin, Alex; Watts, Christopher; Veshchev, Evgeny; Reichle, Roger [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Shigin, Pavel [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); National Research Nuclear University (MEPhI), Kashirskoe shosse, 115409 Moscow (Russian Federation); Sabourin, Flavien [ABMI-Groupe, Parc du Relais BatD 201 Route de SEDS, 13127 Vitrolles (France); Gicquel, Stefan; Mitteau, Raphael [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); González, Jorge [RÜECKER LYPSA, Carretera del Prat, 65, Cornellá de Llobregat (Spain)

    2015-10-15

    Highlights: • This paper describes the current status of the integration efforts to implement diagnostics in the ITER first wall (FW). • Some diagnostics require a plasma facing element attached to the FW, commonly known as a FW diagnostic. Their design must comply not only with their functional requirements but also with the design of the blankets. • An integrated design concept has been developed. It provides a design that respects the requirements of each system. Thermo-mechanical analyses are on-going to confirm that this configuration respects the heat loads limits on the blanket FW. - Abstract: ITER will have about 50 diagnostic systems for machine protection, plasma control and optimization, and understanding the physics of burning plasma. The implementation in the ITER machine is challenging, particularly for the in-vessel diagnostics, region defined between the vacuum vessel and first wall (FW) contours, where space is constrained by the high number of systems. This paper describes the current status of design integration efforts to implement diagnostics in the ITER first wall. These approaches are the basis for detailed optimization and improvement of conceptual interfaces designs between systems.

  6. Time integration of tensor trains

    OpenAIRE

    Lubich, Christian; Oseledets, Ivan; Vandereycken, Bart

    2014-01-01

    A robust and efficient time integrator for dynamical tensor approximation in the tensor train or matrix product state format is presented. The method is based on splitting the projector onto the tangent space of the tensor manifold. The algorithm can be used for updating time-dependent tensors in the given data-sparse tensor train / matrix product state format and for computing an approximate solution to high-dimensional tensor differential equations within this data-sparse format. The formul...

  7. On-line diagnostics for a real time system

    International Nuclear Information System (INIS)

    Sreenivasan, P.

    1976-01-01

    The purpose of an on-line diagnostics is to infuse the ability of self diagnosing in an online computer to enhance its dependability in a real time system. Such a diagnostics evolved for the CDPS of the Fast Breeder Test Reactor at Kalpakkam is reported. The two phases of the diagnostics, i.e., the malfunction detection and post detection action are described in some detail. (A.K.)

  8. Long Pulse Integrator of Variable Integral Time Constant

    International Nuclear Information System (INIS)

    Wang Yong; Ji Zhenshan; Du Xiaoying; Wu Yichun; Li Shi; Luo Jiarong

    2010-01-01

    A kind of new long pulse integrator was designed based on the method of variable integral time constant and deducting integral drift by drift slope. The integral time constant can be changed by choosing different integral resistors, in order to improve the signal-to-noise ratio, and avoid output saturation; the slope of integral drift of a certain period of time can be calculated by digital signal processing, which can be used to deduct the drift of original integral signal in real time to reduce the integral drift. The tests show that this kind of long pulse integrator is good at reducing integral drift, which also can eliminate the effects of changing integral time constant. According to experiments, the integral time constant can be changed by remote control and manual adjustment of integral drift is avoided, which can improve the experiment efficiency greatly and can be used for electromagnetic measurement in Tokamak experiment. (authors)

  9. Development and Integration of a Data Acquisition System for SST-1 Phase-1 Plasma Diagnostics

    International Nuclear Information System (INIS)

    Srivastava, Amit K; Sharma, Manika; Mansuri, Imran; Sharma, Atish; Raval, Tushar; Pradhan, Subrata

    2012-01-01

    Long pulse (of the order of 1000 s or more) SST-1 tokamak experiments demand a data acquisition system that is capable of acquiring data from various diagnostics channels without losing useful data (and hence physics information) while avoiding unnecessary generation of a large volume data. SST-1 Phase-1 tokamak operation has been envisaged with data acquisition of several essential diagnostics channels. These channels demand data acquisition at a sampling rate ranging from 1 kilo samples per second (KSPS) to 1 mega samples per second (MSPS). Considering the technical characteristics and requirements of the diagnostics, a data acquisition system based on PXI and CAMAC has been developed for SST-1 plasma diagnostics. Both these data acquisition systems are scalable. Present data acquisition needs involving slow plasma diagnostics are catered by the PXI based data acquisition system. On the other hand, CAMAC data acquisition hardware meets all requirements of the SST-1 Phase-1 fast plasma diagnostics channels. A graphical user interface for both data acquisition systems (PXI and CAMAC) has been developed using LabVIEW application development software. The collected data on the local hard disk are directly streaming to the central server through a dedicated network for post-shot data analysis. This paper describes the development and integration of the data acquisition system for SST-1 Phase-1 plasma diagnostics. The integrated testing of the developed data acquisition system has been performed using SST-1 central control and diagnostics signal conditioning units. In the absence of plasma shots, the integrated testing of the data acquisition system for the initial diagnostics of SST-1 Phase-1 operation has been performed with simulated physical signals. The primary engineering objective of this integrated testing is to validate the performance of the developed data acquisition system under simulated conditions close to that of actual tokamak operation. The data

  10. Neutronics analysis for integration of ITER diagnostics port EP10

    Energy Technology Data Exchange (ETDEWEB)

    Colling, Bethany, E-mail: bethany.colling@ccfe.ac.uk [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Eade, Tim [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Joyce, Malcolm J. [Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Pampin, Raul; Seyvet, Fabien [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Turner, Andrew [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Udintsev, Victor [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

    2016-11-01

    Shutdown dose rate calculations have been performed on an integrated ITER C-lite neutronics model with equatorial port 10. A ‘fully shielded’ configuration, optimised for a given set of diagnostic designs (i.e. shielding in all available space within the port plug drawers), results in a shutdown dose rate in the port interspace, from the activation of materials comprising equatorial port 10, in excess of 2000 μSv/h. Achieving dose rates of 100 μSv/h or less, as required in areas where hands-on maintenance can be performed, in the port interspace region will be challenging. A combination of methods will need to be implemented, such as reducing mass and/or the use of reduced activation steel in the port interspace, optimisation of the diagnostic designs and shielding of the port interspace floor. Further analysis is required to test these options and the ongoing design optimisation of the EP10 diagnostic systems.

  11. Integrating molecular diagnostics into histopathology training: the Belfast model.

    Science.gov (United States)

    Flynn, C; James, J; Maxwell, P; McQuaid, S; Ervine, A; Catherwood, M; Loughrey, M B; McGibben, D; Somerville, J; McManus, D T; Gray, M; Herron, B; Salto-Tellez, M

    2014-07-01

    Molecular medicine is transforming modern clinical practice, from diagnostics to therapeutics. Discoveries in research are being incorporated into the clinical setting with increasing rapidity. This transformation is also deeply changing the way we practise pathology. The great advances in cell and molecular biology which have accelerated our understanding of the pathogenesis of solid tumours have been embraced with variable degrees of enthusiasm by diverse medical professional specialties. While histopathologists have not been prompt to adopt molecular diagnostics to date, the need to incorporate molecular pathology into the training of future histopathologists is imperative. Our goal is to create, within an existing 5-year histopathology training curriculum, the structure for formal substantial teaching of molecular diagnostics. This specialist training has two main goals: (1) to equip future practising histopathologists with basic knowledge of molecular diagnostics and (2) to create the option for those interested in a subspecialty experience in tissue molecular diagnostics to pursue this training. It is our belief that this training will help to maintain in future the role of the pathologist at the centre of patient care as the integrator of clinical, morphological and molecular information. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  12. INTEGRATED APPLICATION OF OPTICAL DIAGNOSTIC METHODS IN ULCERATIVE COLITIS

    Directory of Open Access Journals (Sweden)

    E. V. Velikanov

    2013-01-01

    Full Text Available Abstract. Our results suggest that the combined use of optical coherent tomography (OCT and fluorescence diagnosis helps to refine the nature and boundaries of the pathological process in the tissue of the colon in ulcerative colitis. Studies have shown that an integrated optical diagnostics allows us to differentiate lesions respectively to histology and to decide on the need for biopsy and venue. This method is most appropriate in cases difficult for diagnosis. 

  13. Diagnostics

    DEFF Research Database (Denmark)

    Donné, A.J.H.; Costley, A.E.; Barnsley, R.

    2007-01-01

    of the measurements—time and spatial resolutions, etc—will in some cases be more stringent. Many of the measurements will be used in the real time control of the plasma driving a requirement for very high reliability in the systems (diagnostics) that provide the measurements. The implementation of diagnostic systems...... on ITER is a substantial challenge. Because of the harsh environment (high levels of neutron and gamma fluxes, neutron heating, particle bombardment) diagnostic system selection and design has to cope with a range of phenomena not previously encountered in diagnostic design. Extensive design and R......&D is needed to prepare the systems. In some cases the environmental difficulties are so severe that new diagnostic techniques are required. The starting point in the development of diagnostics for ITER is to define the measurement requirements and develop their justification. It is necessary to include all...

  14. Integrated control and diagnostic system architectures for future installations

    International Nuclear Information System (INIS)

    Wood, R.; March-Leuba, J.

    2000-01-01

    Nuclear reactors of the 21st century will employ increasing levels of automation and fault tolerance to increase availability, reduce accident risk, and lower operating costs. Key developments in control algorithms, fault diagnostics, fault tolerance, and distributed communications are needed to implement the fully automated plant. It will be equally challenging to integrate developments in separate information and control fields into a cohesive system, which collectively achieves the overall goals of improved safety, reliability, maintainability, and cost-effectiveness. Under the Nuclear Energy Research Initiative (NERI), the US Department of Energy is sponsoring a project to address some of the technical issues involved in meeting the long-range goal of 21st century reactor control systems. This project involves researchers from Oak Ridge National Laboratory, the University of Tennessee, and North Carolina State University. The research tasks under this project focus on some of the first-level breakthroughs in control design, diagnostic techniques, and information system design that will provide a path to enable the design process to be automated in the future. This paper describes the conceptual development of an integrated nuclear plant control and information system architecture, which incorporates automated control system development that can be traced to a set of technical requirements. The expectation is that an integrated plant architecture with optimal control and efficient use of diagnostic information can reduce the potential for operational errors and minimize challenges to the plant safety systems

  15. Steffensen's Integral Inequality on Time Scales

    Directory of Open Access Journals (Sweden)

    Ozkan Umut Mutlu

    2007-01-01

    Full Text Available We establish generalizations of Steffensen's integral inequality on time scales via the diamond- dynamic integral, which is defined as a linear combination of the delta and nabla integrals.

  16. Time-resolving electron temperature diagnostic for ALCATOR C

    International Nuclear Information System (INIS)

    Fairfax, S.A.

    1984-05-01

    A diagnostic that provides time-resolved central electron temperatures has been designed, built, and tested on the ALCATOR C Tokamak. The diagnostic uses an array of fixed-wavelength x-ray crystal monochromators to sample the x-ray continuum and determine the absolute electron temperature. The resolution and central energy of each channel were chosen to exclude any contributions from impurity line radiation. This document describes the need for such a diagnostic, the design methodology, and the results with typical ALCATOR C plasmas. Sawtooth (m = 1) temperature oscillations were observed after pellet fueling of the plasma. This is the first time that such oscillations have been observed with an x-ray temperature diagnostic

  17. Bayesian tomography and integrated data analysis in fusion diagnostics

    Science.gov (United States)

    Li, Dong; Dong, Y. B.; Deng, Wei; Shi, Z. B.; Fu, B. Z.; Gao, J. M.; Wang, T. B.; Zhou, Yan; Liu, Yi; Yang, Q. W.; Duan, X. R.

    2016-11-01

    In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error. In particular, the accuracy of reconstructions is significantly improved by using the non-stationary Gaussian process that can adapt to the varying smoothness of emission distribution. The implementation of this method to a soft X-ray diagnostics on HL-2A has been used to explore relevant physics in equilibrium and MHD instability modes. This project is carried out within a large size inference framework, aiming at an integrated analysis of heterogeneous diagnostics.

  18. Gated integrator PXI-DAQ system for Thomson scattering diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Kiran, E-mail: kkpatel@ipr.res.in; Pillai, Vishal; Singh, Neha; Thomas, Jinto; Kumar, Ajai

    2017-06-15

    Gated Integrator (GI) PXI based data acquisition (DAQ) system has been designed and developed for the ease of acquiring fast Thomson Scattered signals (∼50 ns pulse width). The DAQ system consists of in-house designed and developed GI modules and PXI-1405 chassis with several PXI-DAQ modules. The performance of the developed system has been validated during the SST-1 campaigns. The dynamic range of the GI module depends on the integrating capacitor (C{sub i}) and the modules have been calibrated using 12 pF and 27 pF integrating capacitors. The developed GI module based data acquisition system consists of sixty four channels for simultaneous sampling using eight PXI based digitization modules having eight channels per module. The error estimation and functional tests of this unit are carried out using standard source and also with the fast detectors used for Thomson scattering diagnostics. User friendly Graphical User Interface (GUI) has been developed using LabVIEW on Windows platform to control and acquire the Thomson scattering signal. A robust, easy to operate and maintain with low power consumption, having higher dynamic range with very good sensitivity and cost effective DAQ system is developed and tested for the SST-1 Thomson scattering diagnostics.

  19. Support structure concept for integration of ITER diagnostics in the port cell

    Energy Technology Data Exchange (ETDEWEB)

    Udintsev, V.S., E-mail: victor.udintsev@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Portalès, M.; Giacomin, T.; Darcourt, O.; Direz, M.-F.; Martins, J.P.; Penot, C.; Arumugam, A.P.; Drevon, J.-M.; Friconneau, J.P.; Levesy, B.; Maquet, P.; Patel, K.M.; Pitcher, C.S. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Popova, E. [Russian Federation Domestic Agency, Moscow (Russian Federation); Proust, M. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Ronden, D.M.S. [DIFFER, Nieuwegein (Netherlands); Walker, C.I.; Walsh, M.J.; Watts, C. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France)

    2013-10-15

    Highlights: ► An interspace support structure to support the diagnostic systems from the back of the upper and equatorial port plugs to the biological shield plug. ► Port cell support structures are foreseen to handle the equipment in the port cell. ► Both ISS and PCSS will be supported by means of RH rail system. ► The structures will be positioned with a certain tolerance. ► The proposed concepts are found to fulfil the needs for support of the diagnostics in ITER. -- Abstract: Development of the diagnostics for ITER tokamak, which is presently under construction by several international partners at Cadarache in France, is a major challenge because of severe environment, strict engineering requirements, and the need for high reliability in the measurements. The diagnostic systems in the upper, equatorial and lower port cells on ITER are designed to be integrated within the interspace and port cell support structures. These structures are interfacing with remote handling rail system for the cask operations, thus facilitating the removal and installation of the diagnostics in the port and hence minimizing time for working close to the tokamak. In this paper, the challenges associated with the integration of the diagnostics in the port interspace and port cell, as well as their solutions will be addressed and presented. The interspace and the port cell support structures, as well as their interfaces with the biological shield, will be discussed.

  20. Diagnostic time in digital pathology: A comparative study on 400 cases

    Directory of Open Access Journals (Sweden)

    Aleksandar Vodovnik

    2016-01-01

    Full Text Available Background: Numerous validation studies in digital pathology confirmed its value as a diagnostic tool. However, a longer time to diagnosis than traditional microscopy has been seen as a significant barrier to the routine use of digital pathology. As a part of our validation study, we compared a digital and microscopic diagnostic time in the routine diagnostic setting. Materials and Methods: One senior staff pathologist reported 400 consecutive cases in histology, nongynecological, and fine needle aspiration cytology (20 sessions, 20 cases/session, over 4 weeks. Complex, difficult, and rare cases were excluded from the study to reduce the bias. A primary diagnosis was digital, followed by traditional microscopy, 6 months later, with only request forms available for both. Microscopic slides were scanned at ×20, digital images accessed through the fully integrated laboratory information management system (LIMS and viewed in the image viewer on double 23” displays. A median broadband speed was 299 Mbps. A diagnostic time was measured from the point slides were made available to the point diagnosis was made or additional investigations were deemed necessary, recorded independently in minutes/session and compared. Results: A digital diagnostic time was 1841 and microscopic 1956 min; digital being shorter than microscopic in 13 sessions. Four sessions with shorter microscopic diagnostic time included more cases requiring extensive use of magnifications over ×20. Diagnostic time was similar in three sessions. Conclusions: A diagnostic time in digital pathology can be shorter than traditional microscopy in the routine diagnostic setting, with adequate and stable network speeds, fully integrated LIMS and double displays as default parameters. This also related to better ergonomics, larger viewing field, and absence of physical slide handling, with effects on both diagnostic and nondiagnostic time. Differences with previous studies included a design

  1. A diagnostic tool on time perception of children with ADHD

    NARCIS (Netherlands)

    Gongsook, P.; Peijnenborgh, J.; Sallustro, C.; Spek, van der E.D.; Hu, J.; Bellotti, F.; Rauterberg, G.W.M.; Hendriksen, J.G.M.; De Gloria, A.

    2014-01-01

    ADHD is among the most common childhood developmental disorder which may affect the school achievements. Children with ADHD may show symptoms of time perception problems. Although ADHD is a clinical diagnosis with several approaches, no diagnostic tool has been designed to detect the symptoms of

  2. Microfluidic-integrated biosensors: prospects for point-of-care diagnostics.

    Science.gov (United States)

    Kumar, Suveen; Kumar, Saurabh; Ali, Md Azahar; Anand, Pinki; Agrawal, Ved Varun; John, Renu; Maji, Sagar; Malhotra, Bansi D

    2013-11-01

    There is a growing demand to integrate biosensors with microfluidics to provide miniaturized platforms with many favorable properties, such as reduced sample volume, decreased processing time, low cost analysis and low reagent consumption. These microfluidics-integrated biosensors would also have numerous advantages such as laminar flow, minimal handling of hazardous materials, multiple sample detection in parallel, portability and versatility in design. Microfluidics involves the science and technology of manipulation of fluids at the micro- to nano-liter level. It is predicted that combining biosensors with microfluidic chips will yield enhanced analytical capability, and widen the possibilities for applications in clinical diagnostics. The recent developments in microfluidics have helped researchers working in industries and educational institutes to adopt some of these platforms for point-of-care (POC) diagnostics. This review focuses on the latest advancements in the fields of microfluidic biosensing technologies, and on the challenges and possible solutions for translation of this technology for POC diagnostic applications. We also discuss the fabrication techniques required for developing microfluidic-integrated biosensors, recently reported biomarkers, and the prospects of POC diagnostics in the medical industry. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Time-symmetric integration in astrophysics

    Science.gov (United States)

    Hernandez, David M.; Bertschinger, Edmund

    2018-04-01

    Calculating the long-term solution of ordinary differential equations, such as those of the N-body problem, is central to understanding a wide range of dynamics in astrophysics, from galaxy formation to planetary chaos. Because generally no analytic solution exists to these equations, researchers rely on numerical methods that are prone to various errors. In an effort to mitigate these errors, powerful symplectic integrators have been employed. But symplectic integrators can be severely limited because they are not compatible with adaptive stepping and thus they have difficulty in accommodating changing time and length scales. A promising alternative is time-reversible integration, which can handle adaptive time-stepping, but the errors due to time-reversible integration in astrophysics are less understood. The goal of this work is to study analytically and numerically the errors caused by time-reversible integration, with and without adaptive stepping. We derive the modified differential equations of these integrators to perform the error analysis. As an example, we consider the trapezoidal rule, a reversible non-symplectic integrator, and show that it gives secular energy error increase for a pendulum problem and for a Hénon-Heiles orbit. We conclude that using reversible integration does not guarantee good energy conservation and that, when possible, use of symplectic integrators is favoured. We also show that time-symmetry and time-reversibility are properties that are distinct for an integrator.

  4. Integrated Rapid-Diagnostic-Test Reader Platform on a Cellphone

    Science.gov (United States)

    Mudanyali, Onur; Dimitrov, Stoyan; Sikora, Uzair; Padmanabhan, Swati; Navruz, Isa; Ozcan, Aydogan

    2012-01-01

    We demonstrate a cellphone based Rapid-Diagnostic-Test (RDT) reader platform that can work with various lateral flow immuno-chromatographic assays and similar tests to sense the presence of a target analyte in a sample. This compact and cost-effective digital RDT reader, weighing only ~65 grams, mechanically attaches to the existing camera unit of a cellphone, where various types of RDTs can be inserted to be imaged in reflection or transmission modes under light-emitting-diode (LED) based illumination. Captured raw images of these tests are then digitally processed (within less than 0.2 sec/image) through a smart application running on the cellphone for validation of the RDT as well as for automated reading of its diagnostic result. The same smart application running on the cellphone then transmits the resulting data, together with the RDT images and other related information (e.g., demographic data) to a central server, which presents the diagnostic results on a world-map through geo-tagging. This dynamic spatio-temporal map of various RDT results can then be viewed and shared using internet browsers or through the same cellphone application. We tested this platform using malaria, tuberculosis (TB) as well as HIV RDTs by installing it on both Android based smart-phones as well as an iPhone. Providing real-time spatio-temporal statistics for the prevalence of various infectious diseases, this smart RDT reader platform running on cellphones might assist health-care professionals and policy makers to track emerging epidemics worldwide and help epidemic preparedness. PMID:22596243

  5. Real-Time Remote Diagnostic Monitoring Test-bed in JET

    Energy Technology Data Exchange (ETDEWEB)

    Castro, R. [Asociation Euratom/CIEMAT para Fusion, Madrid (Spain); Kneupner, K.; Purahoo, K. [EURATOM/UKAEA Fusion Association, Abingdon (United Kingdom); Vega, J.; Pereira, A.; Portas, A. [Association EuratomCIEMAT para Fusion, Madrid (Spain); De Arcas, G.; Lopez, J.M. [Universidad Politecnica de Madrid (Spain); Murari, A. [Consorzio RFX, Padova (Italy); Fonseca, A. [Associacao URATOM/IST, Lisboa (Portugal); Contributors, J.E. [JET-EFDA, Abingdon (United Kingdom)

    2009-07-01

    Based on the remote experimentation concept oriented to long pulse shots, a test-bed system has been implemented in JET. It integrates 2 functionalities. The first one is the real-time monitoring, on remote, of a reflectometer diagnostic, to visualize different data outputs and status information. The second one is the integration of dotJET (Diagnostic Overview Tool for JET), which internally provides at JET an overview about the current diagnostic systems state, in order to monitor, on remote, JET diagnostics status. The architecture of the system is formed by: the data generator components, the data distribution system, an access control service, and the client applications. In the test-bed there are two data generators: the acquisition equipment associated with the reflectometer diagnostic that generates data and status information, and dotJET server that centralize the access to the status information of JET diagnostics. The data distribution system has been implemented using a publishing-subscribing technology that receives data from data generators and redistributes them to client applications. And finally, for monitoring, a client application based on Java Web Start technology, and a dotJET client application have been used. There are 3 interesting results from this project. The first one is the analysis of different aspects (data formats, data frame rate, data resolution, etc) related with remote real-time diagnostic monitoring oriented to long pulse experiments. The second one is the definition and implementation of a flexible enough architecture, to be applied to different types of data generated from other diagnostics, and that fits with remote access requirements; and the third one is to have achieved a secure system, taking into account internal networks and firewalls aspects in JET, and securing the access from remote users. For this last issue, PAPI technology has been used, enabling access control based on user attributes, enabling mobile users to

  6. Real-Time Polymerase Chain Reaction: Applications in Diagnostic Microbiology

    Directory of Open Access Journals (Sweden)

    Kordo B. A. Saeed

    2013-11-01

    Full Text Available The polymerase chain reaction (PCR has revolutionized the detection of DNA and RNA. Real-Time PCR (RT-PCR is becoming the gold standard test for accurate, sensitive and fast diagnosis for a large range of infectious agents. Benefits of this procedure over conventional methods for measuring RNA include its sensitivity, high throughout and quantification. RT-PCR assays have advanced the diagnostic abilities of clinical laboratories particularly microbiology and infectious diseases. In this review we would like to briefly discuss RT-PCR in diagnostic microbiology laboratory, beginning with a general introduction to RT-PCR and its principles, setting up an RT PCR, including multiplex systems and the avoidance and remediation of contamination issues. A segment of the review would be devoted to the application of RT-PCR in clinical practice concentrating on its role in the diagnosis and treatment of infectious diseases.

  7. Electronic viewbox: An integrated image diagnostic working station

    International Nuclear Information System (INIS)

    Minato, K.; Komori, M.; Hirakawa, A.; Kuwahara, M.; Yonekura, Y.; Torizuka, K.; Brill, A.B.

    1985-01-01

    Recent development in medical imaging technology have been introducing variety of digital images in clinical medicine, and handling these multi-modality digital images in one place is needed for efficient clinical diagnosis. The authors proposed a concept of an integrated image diagnostic working station, in which a physician can look into all clinical images, can select any key image for diagnosis and can read it in detail. A prototype working station named ''Electronic Viewbox'' has been developed for this purpose. It has three distinctive features. 1. The stored images of a patient are shown at a glance. In order to achieve this function, each original image is attached to a small image, where the data are compressed to reserve the essence of the image, and many of these small images are displayed on a CRT screen. This small image is used as an index for picking up a key image in the archived clinical images. 2. The working station is compact enough to be set on a desk. Only two CRTs and a pointing device are assembled. These two CRT screens are used mutually for retrieving key images and for displaying the original images. 3. All operations can be done interactively using cursor and icons

  8. Time-dependent electron temperature diagnostics for high-power aluminum z-pinch plasmas

    International Nuclear Information System (INIS)

    Sanford, T.W.L.; Nash, T.J.; Mock, R.C.

    1996-08-01

    Time-resolved x-ray pinhole photographs and time-integrated radially-resolved x-ray crystal-spectrometer measurements of azimuthally-symmetric aluminum-wire implosions suggest that the densest phase of the pinch is composed of a hot plasma core surrounded by a cooler plasma halo. The slope of the free-bound x-ray continuum, provides a time-resolved, model-independent diagnostic of the core electron temperature. A simultaneous measurement of the time-resolved K-shell line spectra provides the electron temperature of the spatially averaged plasma. Together, the two diagnostics support a 1-D Radiation-Hydrodynamic model prediction of a plasma whose thermalization on axis produces steep radial gradients in temperature, from temperatures in excess of a kilovolt in the core to below a kilovolt in the surrounding plasma halo

  9. CMOS Time-Resolved, Contact, and Multispectral Fluorescence Imaging for DNA Molecular Diagnostics

    Directory of Open Access Journals (Sweden)

    Nan Guo

    2014-10-01

    Full Text Available Instrumental limitations such as bulkiness and high cost prevent the fluorescence technique from becoming ubiquitous for point-of-care deoxyribonucleic acid (DNA detection and other in-field molecular diagnostics applications. The complimentary metal-oxide-semiconductor (CMOS technology, as benefited from process scaling, provides several advanced capabilities such as high integration density, high-resolution signal processing, and low power consumption, enabling sensitive, integrated, and low-cost fluorescence analytical platforms. In this paper, CMOS time-resolved, contact, and multispectral imaging are reviewed. Recently reported CMOS fluorescence analysis microsystem prototypes are surveyed to highlight the present state of the art.

  10. Development plan for an advanced drilling system with real-time diagnostics (Diagnostics-While-Drilling)

    Energy Technology Data Exchange (ETDEWEB)

    FINGER,JOHN T.; MANSURE,ARTHUR J.; PRAIRIE,MICHAEL R.; GLOWKA,D.A.

    2000-02-01

    This proposal provides the rationale for an advanced system called Diagnostics-while-drilling (DWD) and describes its benefits, preliminary configuration, and essential characteristics. The central concept is a closed data circuit in which downhole sensors collect information and send it to the surface via a high-speed data link, where it is combined with surface measurements and processed through drilling advisory software. The driller then uses this information to adjust the drilling process, sending control signals back downhole with real-time knowledge of their effects on performance. The report presents background of related previous work, and defines a Program Plan for US Department of Energy (DOE), university, and industry cooperation.

  11. Numerical time integration for air pollution models

    NARCIS (Netherlands)

    J.G. Verwer (Jan); W. Hundsdorfer (Willem); J.G. Blom (Joke)

    1998-01-01

    textabstractDue to the large number of chemical species and the three space dimensions, off-the-shelf stiff ODE integrators are not feasible for the numerical time integration of stiff systems of advection-diffusion-reaction equations [ fracpar{c{t + nabla cdot left( vu{u c right) = nabla cdot left(

  12. Real-time measurement and control at JET signal processing and physics analysis for diagnostics

    International Nuclear Information System (INIS)

    Felton, R.; Joffrin, E.; Murari, A.

    2005-01-01

    To meet the requirements of the scientific programme, the EFDA JET real-time measurement and control project has developed an integrated set of real-time plasma measurements, experiment control and communication facilities. Traditional experiments collected instrument data during the plasma pulse and calculated physics data after the pulse. The challenge for continuous tokamak operation is to calculate the physics data in real-time, keeping up with the evolution of the plasma. In JET, many plasma diagnostics have been augmented with extra data acquisition and signal-processing systems so that they can both capture instrument data for conventional post-pulse analysis and calculate calibrated, validated physics results in real-time. During the pulse, the systems send sampled data sets into a network, which distributes the data to several destinations. The receiving systems may do further analysis, integrating data from several measurements, or may control the plasma scenario by heating or fuelling. The simplest real-time diagnostic systems apply scale factors to the signals, as with the electron cyclotron emission (ECE) diagnostic's 96 tuned radiometer channels, giving the electron temperature profile. In various spectroscopy diagnostics, spectral features are least-squares-fitted to measure spectra from several lines of sight, within 50 ms. Ion temperatures and rotation speed can be calculated from the line widths and shifts. For diagnostics using modulation techniques, the systems implement digital-signal processing phase trackers, lock-in amplifiers and filters, e.g., the far infrared (FIR) interferometer samples 15 channels at 400 kHz for 30 s, i.e., six million samples per second. Diagnostics have specific lines of sight, spatial channels, and various sampling rates. The heating/fuelling systems have relatively coarse spatial localisation. Analysis systems have been developed to integrate the basic physics data into smaller sets of controllable parameters on a

  13. An integrated framework for online diagnostic and prognostic health monitoring using a multistate deterioration process

    International Nuclear Information System (INIS)

    Moghaddass, Ramin; Zuo, Ming J.

    2014-01-01

    Efficient asset management is of paramount importance, particularly for systems with costly downtime and failure. As in energy and capital-intensive industries, the economic loss of downtime and failure is huge, the need for a low-cost and integrated health monitoring system has increased significantly over the years. Timely detection of faults and failures through an efficient prognostics and health management (PHM) framework can lead to appropriate maintenance actions to be scheduled proactively to avoid catastrophic failures and minimize the overall maintenance cost of the systems. This paper aims at practical challenges of online diagnostics and prognostics of mechanical systems under unobservable degradation. First, the elements of a multistate degradation structure are reviewed and then a model selection framework is introduced. Important dynamic performance measures are introduced, which can be used for online diagnostics and prognostics. The effectiveness of the result of this paper is demonstrated with a case study on the health monitoring of turbofan engines

  14. Fully 3D printed integrated reactor array for point-of-care molecular diagnostics.

    Science.gov (United States)

    Kadimisetty, Karteek; Song, Jinzhao; Doto, Aoife M; Hwang, Young; Peng, Jing; Mauk, Michael G; Bushman, Frederic D; Gross, Robert; Jarvis, Joseph N; Liu, Changchun

    2018-06-30

    Molecular diagnostics that involve nucleic acid amplification tests (NAATs) are crucial for prevention and treatment of infectious diseases. In this study, we developed a simple, inexpensive, disposable, fully 3D printed microfluidic reactor array that is capable of carrying out extraction, concentration and isothermal amplification of nucleic acids in variety of body fluids. The method allows rapid molecular diagnostic tests for infectious diseases at point of care. A simple leak-proof polymerization strategy was developed to integrate flow-through nucleic acid isolation membranes into microfluidic devices, yielding a multifunctional diagnostic platform. Static coating technology was adopted to improve the biocompatibility of our 3D printed device. We demonstrated the suitability of our device for both end-point colorimetric qualitative detection and real-time fluorescence quantitative detection. We applied our diagnostic device to detection of Plasmodium falciparum in plasma samples and Neisseria meningitides in cerebrospinal fluid (CSF) samples by loop-mediated, isothermal amplification (LAMP) within 50 min. The detection limits were 100 fg for P. falciparum and 50 colony-forming unit (CFU) for N. meningitidis per reaction, which are comparable to that of benchtop instruments. This rapid and inexpensive 3D printed device has great potential for point-of-care molecular diagnosis of infectious disease in resource-limited settings. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Engineering issues on the diagnostic port integration in ITER upper port 18

    Energy Technology Data Exchange (ETDEWEB)

    Pak, Sunil, E-mail: paksunil@nfri.re.kr [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Bertalot, Luciano [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Cheon, Mun Seong [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Giacomin, Thibaud [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Heemskerk, Cock J.M.; Koning, Jarich F. [Heemskerk Innovative Technology, Merelhof 2, 2172 HZ Sassenheim (Netherlands); Lee, Hyeon Gon [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Nemtcev, Grigorii [Institution “PROJECT CENTER ITER”, Akademika Kurchatova sq., Moscow (Russian Federation); Ronden, Dennis M.S. [FOM Institute DIFFER, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Seon, Chang Rae [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Udintsev, Victor; Yukhnov, Nikolay [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Zvonkov, Alexander [Institution “PROJECT CENTER ITER”, Akademika Kurchatova sq., Moscow (Russian Federation)

    2016-11-01

    Highlights: • Diagnostic port integration in the upper port 18 of ITER is presented in order to house the three diagnostic systems. • Issue on the neutron shielding in the upper port 18 is addressed and the shut-down dose rate in the interspace is summarized. • The maintenance strategy in the upper port 18 is described. - Abstract: The upper port #18 (UP18) in ITER hosts three diagnostic systems: the neutron activation system, the Vacuum Ultra-Violet spectrometer system, and the vertical neutron camera. These diagnostics are integrated into three infrastructures in the port: the upper port plug, interspace support structure and port cell support structure. The port integration in UP18 is at the preliminary design stage and the current design of the infrastructure as well as the diagnostic integration is described here. The engineering issues related to neutron shielding and maintenance are addressed and the design approach is suggested.

  16. Integrated Fault Diagnostics of Networks and IT Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — The lecture of the Stanford-IVHM lecture series will give an overview of the approaches in building diagnostic solutions for networks and complex systems. The...

  17. Initial results from the NSTX Real-Time Velocity diagnostic

    Science.gov (United States)

    Podesta, M.; Bell, R. E.

    2011-10-01

    A new diagnostic for fast measurements of plasma rotation through active charge-exchange recombination spectroscopy (CHERS) was installed on NSTX. The diagnostic infers toroidal rotation from carbon ions undergoing charge-exchange with neutrals from a heating Neutral Beam (NB). Each of the 4 channels, distributed along the outer major radius, includes active views intercepting the NB and background views missing the beam. Estimated uncertainties in the measured velocity are system. Signals are acquired on 2 CCD detectors, each controlled by a dedicated PC. Spectra are fitted in real-time through a C++ processing code and velocities are made available to the Plasma Control System for future implementation of feedback on velocity. Results from the initial operation during the 2011 run are discussed, emphasizing the fast dynamics of toroidal rotation, e . g . during L-H mode transition and breaking caused by instabilities and by externally-imposed magnetic perturbations. Work supported by USDOE Contract No. DE-AC02-09CH11466.

  18. [REAL TIME POLYMERASE CHAIN REACTION IN TULAREMIA LABORATORY DIAGNOSTICS].

    Science.gov (United States)

    Kormilitsyna, M I; Mescheryakova, I S; Mikhailova, T V; Dobrovolsky, A A

    2015-01-01

    Enhancement of tularemia laboratory diagnostics by F. tularensis DNA determination in blood sera of patients using real time polymerase chain reaction (RT-PCR). 39 blood sera of patients obtained during transmissive epidemic outbreak of tularemia in Khanty-Mansiysk in 2013 were studied in agglutination reaction, passive hemagglutination, RT-PCR. Specific primers and fluorescent probes were used: ISFTu2F/R+ISFTu2P, Tu14GF/R+tul4-PR2. Advantages of using RT-PCR for early diagnostics of tularemia, when specific antibodies are not detected using traditional immunologic methods, were established. Use of a combination of primers and ISFTu2F/R+ISFTu2P probe allowed to detect F. tularensis DNA in 100% of sera, whereas Tul4G F/R+tul4-PR2 combination--92% of sera. The data were obtained when DNA was isolated from sera using "Proba Rapid" express method. Clinical-epidemiologic diagnosis oftularemia was confirmed by both immune-serologic and RT-PCR methods when sera were studied 3-4 weeks after the onset of the disease. RT-PCR with ISFTu2F/R primers and fluorescent probe ISFTu2P, having high sensitivity and specificity, allows to determine F. tularensis DNA in blood sera of patients at both the early stage and 3-4 weeks after the onset of the disease.

  19. Time Resolved X-Ray Spot Size Diagnostic

    CERN Document Server

    Richardson, Roger; Falabella, Steven; Guethlein, Gary; Raymond, Brett; Weir, John

    2005-01-01

    A diagnostic was developed for the determination of temporal history of an X-ray spot. A pair of thin (0.5 mm) slits image the x-ray spot to a fast scintillator which is coupled to a fast detector, thus sampling a slice of the X-Ray spot. Two other scintillator/detectors are used to determine the position of the spot and total forward dose. The slit signal is normalized to the dose and the resulting signal is analyzed to get the spot size. The position information is used to compensate for small changes due to spot motion and misalignment. The time resolution of the diagnostic is about 1 ns and measures spots from 0.5 mm to over 3 mm. The theory and equations used to calculate spot size and position are presented, as well as data. The calculations assume a symmetric, Gaussian spot. The spot data is generated by the ETA II accelerator, a 2kA, 5.5 MeV, 60ns electron beam focused on a Tantalum target. The spot generated is typically about 1 mm FWHM. Comparisons are made to an X-ray pinhole camera which images th...

  20. Integrated Program of Experimental Diagnostics at the NNSS: An Integrated, Prioritized Work Plan for Diagnostic Development and Maintenance and Supporting Capability

    International Nuclear Information System (INIS)

    2010-01-01

    This Integrated Program of Experimental Diagnostics at the NNSS is an integrated prioritized work plan for the Nevada National Security Site (NNSS), formerly the Nevada Test Site (NTS), program that is independent of individual National Security Enterprise Laboratories (Labs) requests or specific Subprograms being supported. This prioritized work plan is influenced by national priorities presented in the Predictive Capability Framework (PCF) and other strategy documents (Primary and Secondary Assessment Technologies Plans and the Plutonium Experiments Plan). This document satisfies completion criteria for FY 2010 MRT milestone No.3496: Document an integrated, prioritized work plan for diagnostic development, maintenance, and supporting capability. This document is an update of the 3-year NNSS plan written a year ago, September 21, 2009, to define and understand Lab requests for diagnostic implementation. This plan is consistent with Lab interpretations of the PCF, Primary Assessment Technologies, and Plutonium Experiment plans.

  1. Time-scales of stellar rotational variability and starspot diagnostics

    Science.gov (United States)

    Arkhypov, Oleksiy V.; Khodachenko, Maxim L.; Lammer, Helmut; Güdel, Manuel; Lüftinger, Teresa; Johnstone, Colin P.

    2018-01-01

    The difference in stability of starspot distribution on the global and hemispherical scales is studied in the rotational spot variability of 1998 main-sequence stars observed by Kepler mission. It is found that the largest patterns are much more stable than smaller ones for cool, slow rotators, whereas the difference is less pronounced for hotter stars and/or faster rotators. This distinction is interpreted in terms of two mechanisms: (1) the diffusive decay of long-living spots in activity complexes of stars with saturated magnetic dynamos, and (2) the spot emergence, which is modulated by gigantic turbulent flows in convection zones of stars with a weaker magnetism. This opens a way for investigation of stellar deep convection, which is yet inaccessible for asteroseismology. Moreover, a subdiffusion in stellar photospheres was revealed from observations for the first time. A diagnostic diagram was proposed that allows differentiation and selection of stars for more detailed studies of these phenomena.

  2. Development of a real time chemistry monitoring and diagnostic system

    International Nuclear Information System (INIS)

    Gaudreau, T.M.; Millett, P.J.; Bates, J.; Burns, G.

    1998-01-01

    EPRI has developed SMART chem WORKS, which is capable of operating as a real time chemistry diagnostic and monitoring system. A high degree of plant-specific customization is possible which allows discrimination between normal chemistry and off-normal conditions. The initial implementation of the system has been very successful. State of the art technology has been employed which allows remote administration of the system, a flexible, web page display of the output from the system and instant notification of excursions using email and pagers. The second installation of SMART chem WORKS is currently underway at a BWR plant, Grand Gulf. The SMART chem WORKS techniques can be applied to monitor PWR Primary Chemistry, PWR Secondary Chemistry and BWR steam cycle chemistry. A fossil steam cycle simulator will also be developed for application to fossil plants. (J.P.N.)

  3. GENERIC Integrators: Structure Preserving Time Integration for Thermodynamic Systems

    Science.gov (United States)

    Öttinger, Hans Christian

    2018-04-01

    Thermodynamically admissible evolution equations for non-equilibrium systems are known to possess a distinct mathematical structure. Within the GENERIC (general equation for the non-equilibrium reversible-irreversible coupling) framework of non-equilibrium thermodynamics, which is based on continuous time evolution, we investigate the possibility of preserving all the structural elements in time-discretized equations. Our approach, which follows Moser's [1] construction of symplectic integrators for Hamiltonian systems, is illustrated for the damped harmonic oscillator. Alternative approaches are sketched.

  4. The Influence of Time Pressure and Case Complexity on Physicians׳ Diagnostic Performance

    Directory of Open Access Journals (Sweden)

    Dalal A. ALQahtani

    2016-12-01

    Conclusions: Time pressure did not impact the diagnostic performance, whereas the complexity of the clinical case negatively influenced the diagnostic accuracy. Further studies with the enhanced experimental manipulation of time pressure are needed to reveal the effect of time pressure, if any, on a physician׳s diagnostic performance.

  5. Integrable Time-Dependent Quantum Hamiltonians

    Science.gov (United States)

    Sinitsyn, Nikolai A.; Yuzbashyan, Emil A.; Chernyak, Vladimir Y.; Patra, Aniket; Sun, Chen

    2018-05-01

    We formulate a set of conditions under which the nonstationary Schrödinger equation with a time-dependent Hamiltonian is exactly solvable analytically. The main requirement is the existence of a non-Abelian gauge field with zero curvature in the space of system parameters. Known solvable multistate Landau-Zener models satisfy these conditions. Our method provides a strategy to incorporate time dependence into various quantum integrable models while maintaining their integrability. We also validate some prior conjectures, including the solution of the driven generalized Tavis-Cummings model.

  6. Integrated data analysis of fusion diagnostics by means of the Bayesian probability theory

    International Nuclear Information System (INIS)

    Fischer, R.; Dinklage, A.

    2004-01-01

    Integrated data analysis (IDA) of fusion diagnostics is the combination of heterogeneous diagnostics to obtain validated physical results. Benefits from the integrated approach result from a systematic use of interdependencies; in that sense IDA optimizes the extraction of information from sets of different data. For that purpose IDA requires a systematic and formalized error analysis of all (statistical and systematic) uncertainties involved in each diagnostic. Bayesian probability theory allows for a systematic combination of all information entering the diagnostic model by considering all uncertainties of the measured data, the calibration measurements, and the physical model. Prior physics knowledge on model parameters can be included. Handling of systematic errors is provided. A central goal of the integration of redundant or complementary diagnostics is to provide information to resolve inconsistencies by exploiting interdependencies. A comparable analysis of sets of diagnostics (meta-diagnostics) is performed by combining statistical and systematical uncertainties with model parameters and model uncertainties. Diagnostics improvement and experimental optimization and design of meta-diagnostics will be discussed

  7. Real time CT-fluoroscopy: diagnostic and therapeutic applications

    International Nuclear Information System (INIS)

    Mey, J. de; Op de Beeck, B.; Meysman, M.; Noppen, M.; Maeseneer, M. de; Vanhoey, M.; Vincken, W.; Osteaux, M.

    2000-01-01

    The synergetic progression of CT technology and computer hardware has made ultrafast acquisition and image reconstruction possible. This has lead to the availability of CT interactive diagnosis and therapeutic procedures. Making use of our own material (337 intervention procedures during the last 17 months), we have compared our techniques and results to the recent literature data. One of the advantages of the biopsy technique is an improved sensitivity for neoplastic lesions, most certainly in cases of intrapulmonary lesions, surrounded by aerated tissue (now 94% compared to 87% in our previous study). A second advantage is the safety of the technique (only one major complication in our series). Fluid collection drainages, and more complex interventions like local injection of drugs, radio-frequency ablation, wire hook placement and ethanol injection were performed without complication. Yet another interesting feature is the shortening of the procedure time (reduced in average to an 'in-room' time of less than 30 min), which has definite economical implications. Furthermore it increases the patient's comfort and safety, and extends the scope of outpatient procedures (80% outpatient procedures in our material). On the other side the radiation exposure can be raised as an issue, especially when we consider the operator's hands. However, the described technique and the use of dedicated tools can alleviate the problem. As a conclusion, real time CT fluoroscopy has given a new input and broadens the scope of clinical indications of CT-guided diagnostic and therapeutic procedures

  8. Real-time remote diagnostic monitoring test-bed in JET

    International Nuclear Information System (INIS)

    Castro, R.; Kneupner, K.; Vega, J.; De Arcas, G.; Lopez, J.M.; Purahoo, K.; Murari, A.; Fonseca, A.; Pereira, A.; Portas, A.

    2010-01-01

    Based on the remote experimentation concept oriented to long pulse shots, a test-bed system has been implemented in JET. Its main functionality is the real-time monitoring, on remote, of a reflectometer diagnostic, to visualize different data outputs and status information. The architecture of the system is formed by: the data generator components, the data distribution system, an access control service, and the client applications. In the test-bed there is one data generator, which is the acquisition equipment associated with the reflectometer diagnostic that generates data and status information. The data distribution system has been implemented using a publishing-subscribing technology that receives data from data generators and redistributes them to client applications. And finally, for monitoring, a client application based on JAVA Web Start technology has been used. There are three interesting results from this project. The first one is the analysis of different aspects (data formats, data frame rate, data resolution, etc) related with remote real-time diagnostic monitoring oriented to long pulse experiments. The second one is the definition and implementation of an architecture, flexible enough to be applied to different types of data generated from other diagnostics, and that fits with remote access requirements. Finally, the third result is a secure system, taking into account internal networks and firewalls aspects of JET, and securing the access from remote users. For this last issue, PAPI technology has been used, enabling access control based on user attributes, enabling mobile users to monitor diagnostics in real-time, and enabling the integration of this service into the EFDA Federation (Castro et al., 2008 ).

  9. Real-time remote diagnostic monitoring test-bed in JET

    Energy Technology Data Exchange (ETDEWEB)

    Castro, R., E-mail: rodrigo.castro@ciemat.e [Asociacion EURATOM/CIEMAT para Fusion, Madrid (Spain); Kneupner, K. [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon, OX14 3DB (United Kingdom); Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Madrid (Spain); De Arcas, G.; Lopez, J.M. [Universidad Politecnica de Madrid, Grupo I2A2, Madrid (Spain); Purahoo, K. [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon, OX14 3DB (United Kingdom); Murari, A. [Associazione EURATOM-ENEA per la Fusione, Consorzio RFX, 4-35127 Padova (Italy); Fonseca, A. [Associacao EURATOM/IST, Lisbon (Portugal); Pereira, A.; Portas, A. [Asociacion EURATOM/CIEMAT para Fusion, Madrid (Spain)

    2010-07-15

    Based on the remote experimentation concept oriented to long pulse shots, a test-bed system has been implemented in JET. Its main functionality is the real-time monitoring, on remote, of a reflectometer diagnostic, to visualize different data outputs and status information. The architecture of the system is formed by: the data generator components, the data distribution system, an access control service, and the client applications. In the test-bed there is one data generator, which is the acquisition equipment associated with the reflectometer diagnostic that generates data and status information. The data distribution system has been implemented using a publishing-subscribing technology that receives data from data generators and redistributes them to client applications. And finally, for monitoring, a client application based on JAVA Web Start technology has been used. There are three interesting results from this project. The first one is the analysis of different aspects (data formats, data frame rate, data resolution, etc) related with remote real-time diagnostic monitoring oriented to long pulse experiments. The second one is the definition and implementation of an architecture, flexible enough to be applied to different types of data generated from other diagnostics, and that fits with remote access requirements. Finally, the third result is a secure system, taking into account internal networks and firewalls aspects of JET, and securing the access from remote users. For this last issue, PAPI technology has been used, enabling access control based on user attributes, enabling mobile users to monitor diagnostics in real-time, and enabling the integration of this service into the EFDA Federation (Castro et al., 2008 ).

  10. INTEGRAL EDUCATION, TIME AND SPACE: PROBLEMATIZING CONCEPTS

    Directory of Open Access Journals (Sweden)

    Ana Elisa Spaolonzi Queiroz Assis

    2018-03-01

    Full Text Available Integral Education, despite being the subject of public policy agenda for some decades, still carries disparities related to its concept. In this sense, this article aims to problematize not only the concepts of integral education but also the categories time and space contained in the magazines Em Aberto. They were organized and published by the National Institute of Educational Studies Anísio Teixeira (INEP, numbers 80 (2009 and 88 (2012, respectively entitled "Educação Integral e tempo integral" and " Políticas de educação integral em jornada ampliada". The methodology is based on Bardin’s content analysis, respecting the steps of pre-analysis (research corpus formed by the texts in the journals; material exploration (reading the texts encoding data choosing the registration units for categorization; and processing and interpretation of results, based on Saviani’s Historical-Critical Pedagogy. The work reveals convergent and divergent conceptual multiplicity, provoking a discussion about a critical conception of integral education. Keywords: Integral Education. Historical-Critical Pedagogy. Content Analysis.

  11. Integration of the ITER diagnostic plant systems with CODAC

    International Nuclear Information System (INIS)

    Simrock, S.; Barnsley, R.; Bertalot, L.; Hansalia, C.; Klotz, W.D.; Makijarvi, P.; Reichle, R.; Vayakis, G.; Yonekawa, I.; Walker, C.; Wallander, A.; Walsh, M.; Winter, A.

    2011-01-01

    ITER requires extensive diagnostic systems in order to meet the requirements for machine operation, protection, plasma control and physics studies. The realization of these systems is a major challenge not only because of the harsh environment and the nuclear requirements but also with respect to Instrumentation and Control (I and C) of all the 59 diagnostics plants. The Plant Systems I and C are mostly 'in-kind', i.e. procured by the seven ITER Domestic Agencies (DAs), while the Central I and C Systems are 'in-fund', i.e. procured by ITER Organization (IO). Standardization of Plant Systems I and C is of primary importance and has been one of the highest priority tasks of CODAC. The standards are published in the Plant Control Design Handbook (PCDH) which will be followed to ensure a homogeneous design, guarantee high availability and simplify maintenance and support future upgrades. Most important for a successful commissioning and operation of the ITER facility are the concepts of interfacing the diagnostics plant systems with CODAC and the standards for instrumentation and control which must be followed all contributing parties. In this paper, we will elaborate on the concepts of interfacing the diagnostics plant systems with CODAC and the standards that must be followed for the design.

  12. The diagnostic accuracy of integrated positron emission tomography ...

    African Journals Online (AJOL)

    The PET-CT findings, including maximum standardised uptake value (SUVmax), were compared with the gold standard (tissue or microbiological diagnosis). The sensitivity, specificity, positive and negative predictive values and diagnostic accuracy for malignant disease were calculated according to the SUVmax cut-off of ...

  13. Symplectic integrators with adaptive time steps

    Science.gov (United States)

    Richardson, A. S.; Finn, J. M.

    2012-01-01

    In recent decades, there have been many attempts to construct symplectic integrators with variable time steps, with rather disappointing results. In this paper, we identify the causes for this lack of performance, and find that they fall into two categories. In the first, the time step is considered a function of time alone, Δ = Δ(t). In this case, backward error analysis shows that while the algorithms remain symplectic, parametric instabilities may arise because of resonance between oscillations of Δ(t) and the orbital motion. In the second category the time step is a function of phase space variables Δ = Δ(q, p). In this case, the system of equations to be solved is analyzed by introducing a new time variable τ with dt = Δ(q, p) dτ. The transformed equations are no longer in Hamiltonian form, and thus do not benefit from integration methods which would be symplectic for Hamiltonian systems. We analyze two methods for integrating the transformed equations which do, however, preserve the structure of the original equations. The first is an extended phase space method, which has been successfully used in previous studies of adaptive time step symplectic integrators. The second, novel, method is based on a non-canonical mixed-variable generating function. Numerical trials for both of these methods show good results, without parametric instabilities or spurious growth or damping. It is then shown how to adapt the time step to an error estimate found by backward error analysis, in order to optimize the time-stepping scheme. Numerical results are obtained using this formulation and compared with other time-stepping schemes for the extended phase space symplectic method.

  14. Energy drift in reversible time integration

    International Nuclear Information System (INIS)

    McLachlan, R I; Perlmutter, M

    2004-01-01

    Energy drift is commonly observed in reversible integrations of systems of molecular dynamics. We show that this drift can be modelled as a diffusion and that the typical energy error after time T is O(√T). (letter to the editor)

  15. Results of an integration study of a diagnostics port plug in ITER

    International Nuclear Information System (INIS)

    Salasca, Sophie; Cantone, Bruno; Grosman, André; Esposito, Basilio; Moro, Fabio; Morocco, Daniele; Villari, Rosaria; Angelone, Maurizio; Rincon, Esther; Hidalgo, Carlos; Nagy, Daniel; Kocsis, Gabor; Varela, Paulo; Porempovics, Gabor; Perrollaz, Guillaume; Patel, Kunal; Krivchenkov, Yuri; Walsh, Michael

    2013-01-01

    Highlights: ► An extensive study on the integration of diagnostics in a port plug of ITER has been performed. ► It has shown that the diagnostic performances could not be reached if their number was not decreased. ► A design of Diagnostic Shield Modules has been validated through mechanical and thermal analyses. ► These analyses have confirmed that the highest loads are concentrated in the vicinity of the plasma. -- Abstract: Diagnostics in ITER are mandatory to characterize the parameters of plasma and study its interactions with plasma-facing components. Diagnostics components in the vicinity of the plasma are supported by metallic structures called port plugs. At the tokamak mid-plane, these components are installed in port plugs through intermediate structures called drawers. Apart from hosting the diagnostics, the port plugs act as shielding against neutrons and gammas, in order to limit the nuclear loads in crucial components (such as diagnostics and superconducting coils) as well as the dose levels in the controlled zones of the tokamak. The radiation shielding function of the port plugs is ensured through an optimized mixture of heavy metallic materials and water, forming shielding blocks surrounding the diagnostics and called Diagnostic Shield Modules (DSMs). These DSMs constitute the rear part of the drawers (the front part being composed of the Diagnostic First Wall). This paper presents the main results of a study performed in Europe on the integration of a particular diagnostics port plug, the Equatorial Port Plug 1 (EPP1). The paper first provides the results of the EPP1 diagnostics integration analysis. In a second step it focuses on the design of the EPP1 DSMs and summarizes the major results of a thorough set of analyses aiming at studying the DSMs behaviour under different loads, suggesting recommendations to improve their current design

  16. Interconnect rise time in superconducting integrating circuits

    International Nuclear Information System (INIS)

    Preis, D.; Shlager, K.

    1988-01-01

    The influence of resistive losses on the voltage rise time of an integrated-circuit interconnection is reported. A distribution-circuit model is used to present the interconnect. Numerous parametric curves are presented based on numerical evaluation of the exact analytical expression for the model's transient response. For the superconducting case in which the series resistance of the interconnect approaches zero, the step-response rise time is longer but signal strength increases significantly

  17. Diffuse Gliomas for Nonneuropathologists: The New Integrated Molecular Diagnostics.

    Science.gov (United States)

    Lee, Sunhee C

    2018-05-18

    Diffuse gliomas comprise the bulk of "brain cancer" in adults. The recent update to the 4th edition of the World Health Organization's classification of tumors of the central nervous system reflects an unprecedented change in the landscape of the diagnosis and management of diffuse gliomas that will affect all those involved in the management and care of patients. Of the recently discovered gene alterations, mutations in the Krebs cycle enzymes isocitrate dehydrogenases (IDHs) 1 and 2 have fundamentally changed the way the gliomas are understood and classified. Incorporating information on a few genetic parameters (IDH, ATRX and/or p53, and chromosome 1p19q codeletion), a relatively straightforward diagnostic algorithm has been generated with robust and reproducible results that correlate with patients' survival far better than relying on conventional histology alone. Evidence also supports the conclusion that the vast majority of diffuse gliomas without IDH mutations (IDH-wild-type astrocytomas) behave like IDH-wild-type glioblastomas ("molecular GBM"). Together, these changes reflect a big shift in the practice of diagnostic neuropathology in which tumor risk stratification aligns better with molecular information than histology/grading. The purpose of this review is to provide the readers with a brief synopsis of the changes in the 2016 World Health Organization update with an emphasis on diffuse gliomas and to summarize key gene abnormalities on which these classifications are based. Practical points involved in day-to-day diagnostic workup are also discussed, along with a comparison of the various diagnostic tests, including immunohistochemistry, with an emphasis on targeted next-generation sequencing panel technology as a future universal approach.

  18. Hippocampal “Time Cells”: Time versus Path Integration

    Science.gov (United States)

    Kraus, Benjamin J.; Robinson, Robert J.; White, John A.; Eichenbaum, Howard; Hasselmo, Michael E.

    2014-01-01

    SUMMARY Recent studies have reported the existence of hippocampal “time cells,” neurons that fire at particular moments during periods when behavior and location are relatively constant. However, an alternative explanation of apparent time coding is that hippocampal neurons “path integrate” to encode the distance an animal has traveled. Here, we examined hippocampal neuronal firing patterns as rats ran in place on a treadmill, thus “clamping” behavior and location, while we varied the treadmill speed to distinguish time elapsed from distance traveled. Hippocampal neurons were strongly influenced by time and distance, and less so by minor variations in location. Furthermore, the activity of different neurons reflected integration over time and distance to varying extents, with most neurons strongly influenced by both factors and some significantly influenced by only time or distance. Thus, hippocampal neuronal networks captured both the organization of time and distance in a situation where these dimensions dominated an ongoing experience. PMID:23707613

  19. The Crank Nicolson Time Integrator for EMPHASIS.

    Energy Technology Data Exchange (ETDEWEB)

    McGregor, Duncan Alisdair Odum; Love, Edward; Kramer, Richard Michael Jack

    2018-03-01

    We investigate the use of implicit time integrators for finite element time domain approxi- mations of Maxwell's equations in vacuum. We discretize Maxwell's equations in time using Crank-Nicolson and in 3D space using compatible finite elements. We solve the system by taking a single step of Newton's method and inverting the Eddy-Current Schur complement allowing for the use of standard preconditioning techniques. This approach also generalizes to more complex material models that can include the Unsplit PML. We present verification results and demonstrate performance at CFL numbers up to 1000.

  20. Path integration on space times with symmetry

    International Nuclear Information System (INIS)

    Low, S.G.

    1985-01-01

    Path integration on space times with symmetry is investigated using a definition of path integration of Gaussian integrators. Gaussian integrators, systematically developed using the theory of projective distributions, may be defined in terms of a Jacobi operator Green function. This definition of the path integral yields a semiclassical expansion of the propagator which is valid on caustics. The semiclassical approximation to the free particle propagator on symmetric and reductive homogeneous spaces is computed in terms of the complete solution of the Jacobi equation. The results are used to test the validity of using the Schwinger-DeWitt transform to compute an approximation to the coincidence limit of a field theory Green function from a WKB propagator. The method is found not to be valid except for certain special cases. These cases include manifolds constructed from the direct product of flat space and group manifolds, on which the free particle WKB approximation is exact and two sphere. The multiple geodesic contribution to 2 > on Schwarzschild in the neighborhood of rho = 3M is computed using the transform

  1. Aspects for Run-time Component Integration

    DEFF Research Database (Denmark)

    Truyen, Eddy; Jørgensen, Bo Nørregaard; Joosen, Wouter

    2000-01-01

    Component framework technology has become the cornerstone of building a family of systems and applications. A component framework defines a generic architecture into which specialized components can be plugged. As such, the component framework leverages the glue that connects the different inserted...... to dynamically integrate into the architecture of middleware systems new services that support non-functional aspects such as security, transactions, real-time....

  2. Time-Lapse Measurement of Wellbore Integrity

    Science.gov (United States)

    Duguid, A.

    2017-12-01

    Well integrity is becoming more important as wells are used longer or repurposed. For CO2, shale gas, and other projects it has become apparent that wells represent the most likely unintended migration pathway for fluids out of the reservoir. Comprehensive logging programs have been employed to determine the condition of legacy wells in North America. These studies provide examples of assessment technologies. Logging programs have included pulsed neutron logging, ultrasonic well mapping, and cement bond logging. While these studies provide examples of what can be measured, they have only conducted a single round of logging and cannot show if the well has changed over time. Recent experience with time-lapse logging of three monitoring wells at a US Department of Energy sponsored CO2 project has shown the full value of similar tools. Time-lapse logging has shown that well integrity changes over time can be identified. It has also shown that the inclusion of and location of monitoring technologies in the well and the choice of construction materials must be carefully considered. Two of the wells were approximately eight years old at the time of study; they were constructed with steel and fiberglass casing sections and had lines on the outside of the casing running to the surface. The third well was 68 years old when it was studied and was originally constructed as a production well. Repeat logs were collected six or eight years after initial logging. Time-lapse logging showed the evolution of the wells. The results identified locations where cement degraded over time and locations that showed little change. The ultrasonic well maps show clearly that the lines used to connect the monitoring technology to the surface are visible and have a local effect on cement isolation. Testing and sampling was conducted along with logging. It provided insight into changes identified in the time-lapse log results. Point permeability testing was used to provide an in-situ point

  3. Mixed time slicing in path integral simulations

    International Nuclear Information System (INIS)

    Steele, Ryan P.; Zwickl, Jill; Shushkov, Philip; Tully, John C.

    2011-01-01

    A simple and efficient scheme is presented for using different time slices for different degrees of freedom in path integral calculations. This method bridges the gap between full quantization and the standard mixed quantum-classical (MQC) scheme and, therefore, still provides quantum mechanical effects in the less-quantized variables. Underlying the algorithm is the notion that time slices (beads) may be 'collapsed' in a manner that preserves quantization in the less quantum mechanical degrees of freedom. The method is shown to be analogous to multiple-time step integration techniques in classical molecular dynamics. The algorithm and its associated error are demonstrated on model systems containing coupled high- and low-frequency modes; results indicate that convergence of quantum mechanical observables can be achieved with disparate bead numbers in the different modes. Cost estimates indicate that this procedure, much like the MQC method, is most efficient for only a relatively few quantum mechanical degrees of freedom, such as proton transfer. In this regime, however, the cost of a fully quantum mechanical simulation is determined by the quantization of the least quantum mechanical degrees of freedom.

  4. Time resolved two- and three-dimensional plasma diagnostics

    International Nuclear Information System (INIS)

    1991-03-01

    This collection of papers on diagnostics in fusion plasmas contains work on the data analysis of inverse problems and on the experimental arrangements presently used to obtain spatially and temporally resolved plasma radial profiles, including electron and ion temperature, plasma density and plasma current profiles. Refs, figs and tabs

  5. Mixed Portmanteau Test for Diagnostic Checking of Time Series Models

    Directory of Open Access Journals (Sweden)

    Sohail Chand

    2014-01-01

    Full Text Available Model criticism is an important stage of model building and thus goodness of fit tests provides a set of tools for diagnostic checking of the fitted model. Several tests are suggested in literature for diagnostic checking. These tests use autocorrelation or partial autocorrelation in the residuals to criticize the adequacy of fitted model. The main idea underlying these portmanteau tests is to identify if there is any dependence structure which is yet unexplained by the fitted model. In this paper, we suggest mixed portmanteau tests based on autocorrelation and partial autocorrelation functions of the residuals. We derived the asymptotic distribution of the mixture test and studied its size and power using Monte Carlo simulations.

  6. Time-frequency distributions for propulsion-system diagnostics

    Science.gov (United States)

    Griffin, Michael E.; Tulpule, Sharayu

    1991-12-01

    The Wigner distribution and its smoothed versions, i.e., Choi-Williams and Gaussian kernels, are evaluated for propulsion system diagnostics. The approach is intended for off-line kernel design by using the ambiguity domain to select the appropriate Gaussian kernel. The features produced by the Wigner distribution and its smoothed versions correlate remarkably well with documented failure indications. The selection of the kernel on the other hand is very subjective for our unstructured data.

  7. Integration of Diagnostic and Interventional MRI for the Study of Persistent Prostate Cancer After External Beam Radiotherapy

    National Research Council Canada - National Science Library

    Menard, Cynthia

    2007-01-01

    .... We primarily hypothesize that the integration of diagnostic and interventional MRI enables needle biopsy targeting to foci of tumor recurrence after radiotherapy, and will enable a determination...

  8. Integration of Diagnostic and Interventional MRI for the Study of Persistent Prostate Cancer after External Beam Radiotherapy

    National Research Council Canada - National Science Library

    Menard, Cynthia

    2006-01-01

    .... We primarily hypothesize that the integration of diagnostic and interventional MRI enables needle biopsy targeting to foci of tumor recurrence after radiotherapy, and will enable a determination...

  9. Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach

    Directory of Open Access Journals (Sweden)

    Konstantinos Mitsakakis

    2018-02-01

    Full Text Available Monitoring malaria prevalence in humans, as well as vector populations, for the presence of Plasmodium, is an integral component of effective malaria control, and eventually, elimination. In the field of human diagnostics, a major challenge is the ability to define, precisely, the causative agent of fever, thereby differentiating among several candidate (also non-malaria febrile diseases. This requires genetic-based pathogen identification and multiplexed analysis, which, in combination, are hardly provided by the current gold standard diagnostic tools. In the field of vectors, an essential component of control programs is the detection of Plasmodium species within its mosquito vectors, particularly in the salivary glands, where the infective sporozoites reside. In addition, the identification of species composition and insecticide resistance alleles within vector populations is a primary task in routine monitoring activities, aiming to support control efforts. In this context, the use of converging diagnostics is highly desirable for providing comprehensive information, including differential fever diagnosis in humans, and mosquito species composition, infection status, and resistance to insecticides of vectors. Nevertheless, the two fields of human diagnostics and vector control are rarely combined, both at the diagnostic and at the data management end, resulting in fragmented data and mis- or non-communication between various stakeholders. To this direction, molecular technologies, their integration in automated platforms, and the co-assessment of data from multiple diagnostic sources through information and communication technologies are possible pathways towards a unified human vector approach.

  10. Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach.

    Science.gov (United States)

    Mitsakakis, Konstantinos; Hin, Sebastian; Müller, Pie; Wipf, Nadja; Thomsen, Edward; Coleman, Michael; Zengerle, Roland; Vontas, John; Mavridis, Konstantinos

    2018-02-03

    Monitoring malaria prevalence in humans, as well as vector populations, for the presence of Plasmodium , is an integral component of effective malaria control, and eventually, elimination. In the field of human diagnostics, a major challenge is the ability to define, precisely, the causative agent of fever, thereby differentiating among several candidate (also non-malaria) febrile diseases. This requires genetic-based pathogen identification and multiplexed analysis, which, in combination, are hardly provided by the current gold standard diagnostic tools. In the field of vectors, an essential component of control programs is the detection of Plasmodium species within its mosquito vectors, particularly in the salivary glands, where the infective sporozoites reside. In addition, the identification of species composition and insecticide resistance alleles within vector populations is a primary task in routine monitoring activities, aiming to support control efforts. In this context, the use of converging diagnostics is highly desirable for providing comprehensive information, including differential fever diagnosis in humans, and mosquito species composition, infection status, and resistance to insecticides of vectors. Nevertheless, the two fields of human diagnostics and vector control are rarely combined, both at the diagnostic and at the data management end, resulting in fragmented data and mis- or non-communication between various stakeholders. To this direction, molecular technologies, their integration in automated platforms, and the co-assessment of data from multiple diagnostic sources through information and communication technologies are possible pathways towards a unified human vector approach.

  11. Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach

    Science.gov (United States)

    Mitsakakis, Konstantinos; Hin, Sebastian; Wipf, Nadja; Coleman, Michael; Zengerle, Roland; Vontas, John; Mavridis, Konstantinos

    2018-01-01

    Monitoring malaria prevalence in humans, as well as vector populations, for the presence of Plasmodium, is an integral component of effective malaria control, and eventually, elimination. In the field of human diagnostics, a major challenge is the ability to define, precisely, the causative agent of fever, thereby differentiating among several candidate (also non-malaria) febrile diseases. This requires genetic-based pathogen identification and multiplexed analysis, which, in combination, are hardly provided by the current gold standard diagnostic tools. In the field of vectors, an essential component of control programs is the detection of Plasmodium species within its mosquito vectors, particularly in the salivary glands, where the infective sporozoites reside. In addition, the identification of species composition and insecticide resistance alleles within vector populations is a primary task in routine monitoring activities, aiming to support control efforts. In this context, the use of converging diagnostics is highly desirable for providing comprehensive information, including differential fever diagnosis in humans, and mosquito species composition, infection status, and resistance to insecticides of vectors. Nevertheless, the two fields of human diagnostics and vector control are rarely combined, both at the diagnostic and at the data management end, resulting in fragmented data and mis- or non-communication between various stakeholders. To this direction, molecular technologies, their integration in automated platforms, and the co-assessment of data from multiple diagnostic sources through information and communication technologies are possible pathways towards a unified human vector approach. PMID:29401670

  12. Integration of ITER in-vessel diagnostic components in the vacuum vessel

    International Nuclear Information System (INIS)

    Encheva, A.; Bertalot, L.; Macklin, B.; Vayakis, G.; Walker, C.

    2009-01-01

    The integration of ITER in-vessel diagnostic components is an important engineering activity. The positioning of the diagnostic components must correlate not only with their functional specifications but also with the design of the major parts of ITER torus, in particular the vacuum vessel, blanket modules, blanket manifolds, divertor, and port plugs, some of which are not yet finally designed. Moreover, the recently introduced Edge Localised Mode (ELM)/Vertical Stability (VS) coils mounted on the vacuum vessel inner wall call for not only more than a simple review of the engineering design settled down for several years now, but also for a change in the in-vessel distribution of the diagnostic components and their full impact has yet to be determined. Meanwhile, the procurement arrangement (a document defining roles and responsibilities of ITER Organization and Domestic Agency(s) (DAs) for each in-kind procurement including technical scope of work, quality assurance requirements, schedule, administrative matters) for the vacuum vessel must be finalized. These make the interface process even more challenging in terms of meeting the vacuum vessel (VV) procurement arrangement's deadline. The process of planning the installation of all the ITER diagnostics and integrating their installation into the ITER Integrated Project Schedule (IPS) is now underway. This paper covers the progress made recently on updating and issuing the interfaces of the in-vessel diagnostic components with the vacuum vessel, outlines the requirements for their attachment and summarises the installation sequence.

  13. Efficient Integration, Validation and Troubleshooting in Multimodal Distributed Diagnostic Schemes, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In general, development and validation of diagnostic models for complex safety critical systems are time and cost intensive jobs. The proposed Phase-II effort will...

  14. Svelte Integrated Delivery System Performance Examined Through Diagnostic Catheter Delivery : The SPEED Registry

    NARCIS (Netherlands)

    Khattab, Ahmed A.; Nijhoff, Freek; Schofer, Joachim; Berland, Jacques; Meier, Bernhard; Nietlispach, Fabian; Agostoni, Pierfrancesco; Brucks, Steffen; Stella, Pieter

    2015-01-01

    Aims: The multi-center SPEED registry evaluated the procedural success and in-hospital clinical outcomes of direct stenting with the Svelte 'all-in-one' coronary stent Integrated Delivery System (IDS) through diagnostic catheters to identify the clinical indications for which this approach is

  15. INTEGRATED DIAGNOSTICS AND CORRECTION OF SLEEP DISORDERS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    S. A. Nemkova

    2015-01-01

    Full Text Available The article is devoted to the actual problem of modern pediatrics and neurology ― a comprehensive diagnosis and correction of sleep disorders in children. Detail the features of the clinical manifestations of sleep disorders in childhood (insomnia and parasomnia, great attention is paid to sleep apnea syndrome as a risk factor for somatic and psychopathological disorders in children. Highlight the current capabilities of complex instrumental diagnosis of sleep disorders with the use of highly effective methods of polysomnography and pulse oximetry. The actual dimensions as non-drug and drug treatment of sleep disorders in children, taking into account the pathogenetic features of their occurrence. From the standpoint of evidence-based medicine demonstrate efficient methods of herbal medicine, developed on the basis of traditional Chinese recipes, as well as modern nootropics and magnesium preparations. It is shown that sleep disorders in children not only lead to a deterioration of emotional mood, cognitive function, health and school performance, but also are associated with increasing risk of somatic disorders, which determines the need for timely diagnosis and comprehensive differentiated medical and psychological data correction of pathological conditions, taking into account the neurophysiological and biochemical mechanisms of their development, as well as polymorphism of clinical manifestations, in order to increase the effectiveness of treatment and quality of life of patients.  

  16. Telecontrol - Expert systems. Real-time monitoring and remote diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Lam, A.

    1996-09-01

    The role of expert systems in programming simple and complex tasks in utilities companies was discussed with examples from B.C. Hydro, where expert systems have been used in such diverse applications as an in-house programmable logic controller (PLC) training course, and a machine audit on a 150 MW steam turbine generating unit at their Burrard Thermal Generating Plant. The PLC tutoring program uses expert system technology for the air blast circuit breakers` air drier system, for individualized on-site training. The steam turbine audits (an eight-month long project) were performed remotely by dialing an on-site computer configured with customized expert software. Details of these, and other potential applications, such as transformer monitoring and diagnostics, circuit breaker performance analysis, and information management, were described.

  17. Integrated LTCC pressure/flow/temperature multisensor for compressed air diagnostics.

    Science.gov (United States)

    Fournier, Yannick; Maeder, Thomas; Boutinard-Rouelle, Grégoire; Barras, Aurélie; Craquelin, Nicolas; Ryser, Peter

    2010-01-01

    We present a multisensor designed for industrial compressed air diagnostics and combining the measurement of pressure, flow, and temperature, integrated with the corresponding signal conditioning electronics in a single low-temperature co-fired ceramic (LTCC) package. The developed sensor may be soldered onto an integrated electro-fluidic platform by using standard surface mount device (SMD) technology, e.g., as a standard electronic component would be on a printed circuit board, obviating the need for both wires and tubes and thus paving the road towards low-cost integrated electro-fluidic systems. Several performance aspects of this device are presented and discussed, together with electronics design issues.

  18. An Integrated Diagnostic Framework to Manage Organization Sustainable Growth: An Empirical Case

    Directory of Open Access Journals (Sweden)

    Jingxiao Zhang

    2016-03-01

    Full Text Available This research aims to develop a quantitative diagnostic framework by combining the Weisbord six-box model with the growth management model to focus on an organization’s internally driven sustainable management system. The research adopted an instrument developed by Preziosi and an extended Weisbord six-box model. The research employed a survey to collect 180 samples in a Chinese petrol company and applied the comparative method: (a the average score method; and (b the entropy method to confirm the growth level of the company. The survey also attempted to identify corresponding top growth influence factors using the obstacle degree formula. The results showed that the integrated diagnostic framework worked well to diagnose a regional but large Chinese petroleum company. In other words, the research successfully quantified the growth position and top influence factors and helped put forward specific suggestions to drive the organization of sustainable development. The method confirmed this organization during the fourth phase of five phases. In addition, top influence factors hindering the internal growth were (a the lack of task engagement with energy and time; (b the lack of personal work units; and (c a poor division of labor for reaching sustainable growth rates. The research provides a generic theoretical framework support to incorporate growth management models into an organizational diagnosis to obtain sustainable growth. It further highlights and practices guidelines in examining actual growth management levels in companies and discusses top influence factors to design efficient management systems to pursue organizational growth in a multitude of industrial contexts.

  19. Radiocardiography of minimal transit times: a useful diagnostic procedure

    International Nuclear Information System (INIS)

    Schicha, H.; Vyska, K.; Becker, V.; Feinendegen, L.E.; Duesseldorf Univ., F.R. Germany)

    1975-01-01

    Contrary to mean transit times, minimal transit times are the differences between arrival times of an indicator. Arrival times in various cardiac compartments can be easily measured with radioisotopes and fast gamma cameras permitting data processing. This paper summarizes data selected from more than 1500 measurements made so far on normal individuals and patients with valvular heart disease, myocardial insufficiency, digitalis effect, atrial fibrillation, hypothyroidism, hyperthyroidism, effort-syndrome and coronary artery disease. (author)

  20. Dynamics model for real time diagnostics of Triga RC-1 system

    International Nuclear Information System (INIS)

    Gadomski, A.M.; Nanni, V.; Meo, G.

    1988-01-01

    This paper presents dynamics model of TRIGA RC-1 reactor system. The model is dedicated to the real-time early fault detection during a reactor operation in one week exploitation cycle. The algorithms are specially suited for real-time, long time and also accelerated simulations with assumed diagnostic oriented accuracy. The approximations, modular structure, numerical methods and validation are discussed. The elaborated model will be build in the TRIGA Supervisor System and TRIGA Diagnostic Simulator

  1. Dynamics model for real time diagnostics of TRIGA RC-1 system

    International Nuclear Information System (INIS)

    Gadomski, A.M.; Nanni, V.; Meo, G.B.

    1986-01-01

    This paper presents dynamics model of TRIGA RC-1 reactor system. The model is dedicated to the real-time early fault detection during a reactor operation in one week exploitation cycle. The algorithms are specially suited for real-time, long time and also accelerated simulations with assumed diagnostic oriented accuracy. The approximations, modular structure, numerical methods and validation are discussed. The elaborated model will be build in the TRIGA Supervisory System and TRIGA Diagnostic Simulator. (author)

  2. Opto-electronic DNA chip-based integrated card for clinical diagnostics.

    Science.gov (United States)

    Marchand, Gilles; Broyer, Patrick; Lanet, Véronique; Delattre, Cyril; Foucault, Frédéric; Menou, Lionel; Calvas, Bernard; Roller, Denis; Ginot, Frédéric; Campagnolo, Raymond; Mallard, Frédéric

    2008-02-01

    Clinical diagnostics is one of the most promising applications for microfluidic lab-on-a-chip or lab-on-card systems. DNA chips, which provide multiparametric data, are privileged tools for genomic analysis. However, automation of molecular biology protocol and use of these DNA chips in fully integrated systems remains a great challenge. Simplicity of chip and/or card/instrument interfaces is amongst the most critical issues to be addressed. Indeed, current detection systems for DNA chip reading are often complex, expensive, bulky and even limited in terms of sensitivity or accuracy. Furthermore, for liquid handling in the lab-on-cards, many devices use complex and bulky systems, either to directly manipulate fluids, or to ensure pneumatic or mechanical control of integrated valves. All these drawbacks prevent or limit the use of DNA-chip-based integrated systems, for point-of-care testing or as a routine diagnostics tool. We present here a DNA-chip-based protocol integration on a plastic card for clinical diagnostics applications including: (1) an opto-electronic DNA-chip, (2) fluid handling using electrically activated embedded pyrotechnic microvalves with closing/opening functions. We demonstrate both fluidic and electric packaging of the optoelectronic DNA chip without major alteration of its electronical and biological functionalities, and fluid control using novel electrically activable pyrotechnic microvalves. Finally, we suggest a complete design of a card dedicated to automation of a complex biological protocol with a fully electrical fluid handling and DNA chip reading.

  3. Time for creative integration in medical sociology.

    Science.gov (United States)

    Levine, S

    1995-01-01

    The burgeoning of medical sociology has sometimes been accompanied by unfortunate parochialism and the presence of opposing intellectual camps that ignore and even impugn each other's work. We have lost opportunities to achieve creative discourse and integration of different perspectives, methods, and findings. At this stage we should consider how we can foster creative integration within our field.

  4. Time varying voltage combustion control and diagnostics sensor

    Science.gov (United States)

    Chorpening, Benjamin T [Morgantown, WV; Thornton, Jimmy D [Morgantown, WV; Huckaby, E David [Morgantown, WV; Fincham, William [Fairmont, WV

    2011-04-19

    A time-varying voltage is applied to an electrode, or a pair of electrodes, of a sensor installed in a fuel nozzle disposed adjacent the combustion zone of a continuous combustion system, such as of the gas turbine engine type. The time-varying voltage induces a time-varying current in the flame which is measured and used to determine flame capacitance using AC electrical circuit analysis. Flame capacitance is used to accurately determine the position of the flame from the sensor and the fuel/air ratio. The fuel and/or air flow rate (s) is/are then adjusted to provide reduced flame instability problems such as flashback, combustion dynamics and lean blowout, as well as reduced emissions. The time-varying voltage may be an alternating voltage and the time-varying current may be an alternating current.

  5. The diagnostic value of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time.

    Science.gov (United States)

    Kam, Sung Chul; Han, Deok Hyun; Lee, Sung Won

    2011-03-01

    Premature ejaculation (PE) is the most prevalent male ejaculation disorder. The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the DSM-IV-TR criteria in diagnostic PE. To evaluate the diagnostic value of the PEDT and its association with intravaginal ejaculatory latency time (IELT). (i) Korean validation of PEDT: data was collected from men interviewed by one of the two clinical experts, who made a diagnostic of present or absence of PE, using DSM-IV-TR criteria. A total of 103 patients with PE and 100 men without PE were enrolled into the study and requested to complete the PEDT; and (ii) The correlation between IELT and PEDT: 200 participants were enrolled and each participant was asked to make out PEDT. All participants were requested to measure IELT. Validity and reliability of the PEDT and its association with IELT. The geometric mean IELT of the PE group was 115.37 ± 78.14 seconds. The number of men reporting IELTs of 2 minutes were 28 (28.6%), 29 (29.6%), and 41 (41.8%), respectively. The Cronbach's alpha score was calculated as 0.93, showing adequate internal consistency. The test-retest correlation coefficients of each item were higher than 0.72 and the correlation coefficients of the total score was 0.88. (P IELT showed an adequate negative correlation. (ρ = -0.77, P IELT ≤ 2 minutes) and IELT showed a negative correlation. (ρ = -0.6, P < 0.0001) The PEDT was highly effective in detecting the presence of PE. The result of our study supports its validity as a diagnostic tool in the clinical setting. © 2010 International Society for Sexual Medicine.

  6. Diagnostic imaging in pregraduate integrated curricula; Radiologie in einem praegraduellen problembasiert-integrierten Medizincurriculum

    Energy Technology Data Exchange (ETDEWEB)

    Kainberger, F.; Kletter, K. [Universitaetsklinik fuer Radiodiagnostik, Medizinische Univ. Wien (Austria)

    2007-11-15

    Pregraduate medical curricula are currently undergoing a reform process that is moving away from a traditional discipline-related structure and towards problem-based integrated forms of teaching. Imaging sciences, with their inherently technical advances, are specifically influenced by the effects of paradigm shifts in medical education. The teaching of diagnostic radiology should be based on the definition of three core competencies: in vivo visualization of normal and abnormal morphology and function, diagnostic reasoning, and interventional treatment. On the basis of these goals, adequate teaching methods and e-learning tools should be implemented by focusing on case-based teaching. Teaching materials used in the fields of normal anatomy, pathology, and clinical diagnosis may help diagnostic radiology to play a central role in modern pregraduate curricula. (orig.)

  7. Generic Diagnostic Port Integration for the Equatorial Port Plug of ITER

    International Nuclear Information System (INIS)

    Doceul, L.; Chappuis, Ph.; Portafaix, Ch.; Guillaume, T.; Bruyere, Ch.; Walker, Ch.; Ingesson, Ch.; Ciattaglia, E.; Salasca, S.; Eric, T.

    2006-01-01

    ITER requires an extensive set of diagnostic systems to provide several key functions such as protection of the device, input to plasma control systems and evaluation of the plasma performance. Most of these diagnostics system are to be integrated in port plugs, which are water cooled stainless steel structures (approximately: 50 t, 2 m x 2 m x 4 m) inserted into the vacuum-vessel ports. The port plug must perform basic functions such as providing neutron and gamma shielding, supporting the first wall armour and shielding blanket material, closing the vacuum vessel ports, supporting the diagnostic equipment (within the primary vacuum, on the primary vacuum boundary and in the port interspace). CEA (Commissariat l'Energie Atomique) has contributed to the engineering activities on the port plugs and has more particularly focused on the design and diagnostic integration in the representative equatorial port plug EQ01. The specific CEA contributions were to perform the general engineering, structural and thermal analysis. These detailed analysis have highlighted some design issues which were worked out through different solutions. This paper will contain the description of the engineering activities performed such as: - The conceptual design of the EQ01 and the associated diagnostics, such as the visible and infrared optical diagnostic, - The static mechanical calculations, taking into account the electromagnetic loads occurring during fast transient plasma events, - The dynamic calculation constituted of modal and transient analysis under the same electromagnetic loads to estimate the dynamic amplification factor due to the resonance phenomenon, - The thermal assessment under the neutronic load of the water-cooled stainless steel structure, - The seismic response of the port plug inside the vacuum vessel, taking into account the ground spectra and soil conditions in the Cadarache site. (author)

  8. Integral diagnostic in the failure causes of external corrosion of a natural gas transport pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Mora-Mendoza, J.L.; Saucedo-Robles, L.C.; Rodriguez-Clemente, H. [PEMEX Gas y Petroquimica Basica, Subdireccion de Ductos; Marina Nacional 329, Edificio B-1, Piso 8, Col. Huasteca, D.F., CP 11311 (Mexico); Gonzalez-Nunez, M.A. [Instituto de Investigaciones Electricas, Reforma 113, Col. Palmira, Cuernavaca, Morelos, CP 62490 (Mexico); Zavala-Olivares, G.; Hernandez-Gayosso, M.J. [Instituto Mexicano del Petroleo, Direccion de Exploracion y Produccion, Eje Central Lazaro Cardenas Norte 152, Col. San Bartolo Atepehuacan, D.F., CP 07730 (Mexico)

    2011-08-15

    The objective of this study consisted in investigating the possible causes which give rise to the presence of low wall pipe thicknesses on a 16'' natural gas transport pipeline, even though during the last 12-year period cathodic protection (CP) potentials were kept in the protection range at which external corrosion should not occur. Results from in-line inspection from a 16'' natural gas transport pipeline showed 46 indications with more than 80% wall thickness lost due to external corrosion in the second segment of the pipeline. Direct inspection at the indication locations, review of the CP system performance, pipeline maintenance programs and studies, allowed to make an integral diagnostic where it was found out that the main cause of external corrosion was an inappropriate coating application since the pipeline construction, this situation has originated the increase of CP shielding effects through time. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Global integration in times of crisis

    DEFF Research Database (Denmark)

    Jensen, Camilla

    shock) from other subsidiaries downstream in the value chain. While in a comparative perspective multinational subsidiaries are found to perform relatively better than local firms that are integrated differently (arms' length) in global production networks (e.g. offshoring outsourcing). This paper tries...... to reconcile these findings by testing a number of hypothesis about global integration strategies in the context of the global financial crisis and how it affected exporting among multinational subsidiaries operating out of Turkey. Controlling for the impact that depreciations and exchange rate volatility has...... integration strategies throughout the course of the global financial crisis....

  10. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation

    International Nuclear Information System (INIS)

    Lent, Wineke A.M. van; Deetman, Joost W.; Teertstra, H. Jelle; Muller, Sara H.; Hans, Erwin W.; Harten, Wim H. van

    2012-01-01

    Introduction: To examine the use of computer simulation to reduce the time between the CT request and the consult in which the CT report is discussed (diagnostic track) while restricting idle time and overtime. Methods: After a pre implementation analysis in our case study hospital, by computer simulation three scenarios were evaluated on access time, overtime and idle time of the CT; after implementation these same aspects were evaluated again. Effects on throughput time were measured for outpatient short-term and urgent requests only. Conclusion: The pre implementation analysis showed an average CT access time of 9.8 operating days and an average diagnostic track of 14.5 operating days. Based on the outcomes of the simulation, management changed the capacity for the different patient groups to facilitate a diagnostic track of 10 operating days, with a CT access time of 7 days. After the implementation of changes, the average diagnostic track duration was 12.6 days with an average CT access time of 7.3 days. The fraction of patients with a total throughput time within 10 days increased from 29% to 44% while the utilization remained equal with 82%, the idle time increased by 11% and the overtime decreased by 82%. The fraction of patients that completed the diagnostic track within 10 days improved with 52%. Computer simulation proved useful for studying the effects of proposed scenarios in radiology management. Besides the tangible effects, the simulation increased the awareness that optimizing capacity allocation can reduce access times.

  11. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lent, Wineke A.M. van, E-mail: w.v.lent@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); University of Twente, IGS Institute for Innovation and Governance Studies, Department of Health Technology Services Research (HTSR), Enschede (Netherlands); Deetman, Joost W., E-mail: j.deetman@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Teertstra, H. Jelle, E-mail: h.teertstra@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Muller, Sara H., E-mail: s.muller@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Hans, Erwin W., E-mail: e.w.hans@utwente.nl [University of Twente, School of Management and Governance, Dept. of Industrial Engineering and Business Intelligence Systems, Enschede (Netherlands); Harten, Wim H. van, E-mail: w.v.harten@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); University of Twente, IGS Institute for Innovation and Governance Studies, Department of Health Technology Services Research (HTSR), Enschede (Netherlands)

    2012-11-15

    Introduction: To examine the use of computer simulation to reduce the time between the CT request and the consult in which the CT report is discussed (diagnostic track) while restricting idle time and overtime. Methods: After a pre implementation analysis in our case study hospital, by computer simulation three scenarios were evaluated on access time, overtime and idle time of the CT; after implementation these same aspects were evaluated again. Effects on throughput time were measured for outpatient short-term and urgent requests only. Conclusion: The pre implementation analysis showed an average CT access time of 9.8 operating days and an average diagnostic track of 14.5 operating days. Based on the outcomes of the simulation, management changed the capacity for the different patient groups to facilitate a diagnostic track of 10 operating days, with a CT access time of 7 days. After the implementation of changes, the average diagnostic track duration was 12.6 days with an average CT access time of 7.3 days. The fraction of patients with a total throughput time within 10 days increased from 29% to 44% while the utilization remained equal with 82%, the idle time increased by 11% and the overtime decreased by 82%. The fraction of patients that completed the diagnostic track within 10 days improved with 52%. Computer simulation proved useful for studying the effects of proposed scenarios in radiology management. Besides the tangible effects, the simulation increased the awareness that optimizing capacity allocation can reduce access times.

  12. Amplitude Integrated Electroencephalography Compared With Conventional Video EEG for Neonatal Seizure Detection: A Diagnostic Accuracy Study.

    Science.gov (United States)

    Rakshasbhuvankar, Abhijeet; Rao, Shripada; Palumbo, Linda; Ghosh, Soumya; Nagarajan, Lakshmi

    2017-08-01

    This diagnostic accuracy study compared the accuracy of seizure detection by amplitude-integrated electroencephalography with the criterion standard conventional video EEG in term and near-term infants at risk of seizures. Simultaneous recording of amplitude-integrated EEG (2-channel amplitude-integrated EEG with raw trace) and video EEG was done for 24 hours for each infant. Amplitude-integrated EEG was interpreted by a neonatologist; video EEG was interpreted by a neurologist independently. Thirty-five infants were included in the analysis. In the 7 infants with seizures on video EEG, there were 169 seizure episodes on video EEG, of which only 57 were identified by amplitude-integrated EEG. Amplitude-integrated EEG had a sensitivity of 33.7% for individual seizure detection. Amplitude-integrated EEG had an 86% sensitivity for detection of babies with seizures; however, it was nonspecific, in that 50% of infants with seizures detected by amplitude-integrated EEG did not have true seizures by video EEG. In conclusion, our study suggests that amplitude-integrated EEG is a poor screening tool for neonatal seizures.

  13. Real-time system for processing regime diagnostic on accelerator

    International Nuclear Information System (INIS)

    Yeran, L.V.; Karasyov, S.P.; Uvarov, V.L.; Shlyakhov, I.N.

    2004-01-01

    The automatic real-time system operating at the LU-10 linac and providing measurements of the parameters such as the beam current (average and pulse values), the electron energy, the linear density distribution of beam current, and also the conveyor speed is described in the paper

  14. Real-time image fusion involving diagnostic ultrasound

    DEFF Research Database (Denmark)

    Ewertsen, Caroline; Săftoiu, Adrian; Gruionu, Lucian G

    2013-01-01

    The aim of our article is to give an overview of the current and future possibilities of real-time image fusion involving ultrasound. We present a review of the existing English-language peer-reviewed literature assessing this technique, which covers technical solutions (for ultrasound...

  15. Data acquisition and real-time signal processing of plasma diagnostics on ASDEX Upgrade using LabVIEW RT

    International Nuclear Information System (INIS)

    Giannone, L.; Cerna, M.; Cole, R.; Fitzek, M.; Kallenbach, A.; Lueddecke, K.; McCarthy, P.J.; Scarabosio, A.; Schneider, W.; Sips, A.C.C.; Treutterer, W.; Vrancic, A.; Wenzel, L.; Yi, H.; Behler, K.; Eich, T.; Eixenberger, H.; Fuchs, J.C.; Haas, G.; Lexa, G.

    2010-01-01

    The existing VxWorks real-time system for the position and shape control in ASDEX Upgrade has been extended to calculate magnetic flux surfaces in real-time using a multi-core PCI Express system running LabVIEW RT 8.6. real-time signal processing of bolometers and manometers is performed with the on-board FPGA to calculate the measured radiated power flux and particle flux respectively from the raw data. Radiation feedback experiments use halo current measurements from the outer divertor with real-time median filter pre-processing to remove the excursions produced by ELMs. Integration of these plasma diagnostics into the control system by the exchange of XML sheets for communicating the real-time variables to be produced and consumed is in operation. Reflective memory and UDP are employed by the LabVIEW RT plasma diagnostics to communicate with the control system and other plasma diagnostics in a multi-platform real-time network.

  16. Data acquisition and real-time signal processing of plasma diagnostics on ASDEX Upgrade using LabVIEW RT

    Energy Technology Data Exchange (ETDEWEB)

    Giannone, L., E-mail: Louis.Giannone@ipp.mpg.d [Max-Planck-Institut fuer Plasmaphysik, EURATOM-IPP Association, D-85748 Garching (Germany); Cerna, M. [National Instruments, Austin, TX 78759-3504 (United States); Cole, R.; Fitzek, M. [Unlimited Computer Systems GmbH, 82393 Iffeldorf (Germany); Kallenbach, A. [Max-Planck-Institut fuer Plasmaphysik, EURATOM-IPP Association, D-85748 Garching (Germany); Lueddecke, K. [Unlimited Computer Systems GmbH, 82393 Iffeldorf (Germany); McCarthy, P.J. [Department of Physics, University College Cork, Association EURATOM-DCU, Cork (Ireland); Scarabosio, A.; Schneider, W.; Sips, A.C.C.; Treutterer, W. [Max-Planck-Institut fuer Plasmaphysik, EURATOM-IPP Association, D-85748 Garching (Germany); Vrancic, A.; Wenzel, L.; Yi, H. [National Instruments, Austin, TX 78759-3504 (United States); Behler, K.; Eich, T.; Eixenberger, H.; Fuchs, J.C.; Haas, G.; Lexa, G. [Max-Planck-Institut fuer Plasmaphysik, EURATOM-IPP Association, D-85748 Garching (Germany)

    2010-07-15

    The existing VxWorks real-time system for the position and shape control in ASDEX Upgrade has been extended to calculate magnetic flux surfaces in real-time using a multi-core PCI Express system running LabVIEW RT 8.6. real-time signal processing of bolometers and manometers is performed with the on-board FPGA to calculate the measured radiated power flux and particle flux respectively from the raw data. Radiation feedback experiments use halo current measurements from the outer divertor with real-time median filter pre-processing to remove the excursions produced by ELMs. Integration of these plasma diagnostics into the control system by the exchange of XML sheets for communicating the real-time variables to be produced and consumed is in operation. Reflective memory and UDP are employed by the LabVIEW RT plasma diagnostics to communicate with the control system and other plasma diagnostics in a multi-platform real-time network.

  17. Development of procedures to ensure quality and integrity in Tandem Mirror Experiment-Upgrade (TMX-U) diagnostics systems

    International Nuclear Information System (INIS)

    Coutts, G.W.; Coon, M.L.; Hinz, A.F.; Hornady, R.S.; Lang, D.D.; Lund, N.P.

    1983-01-01

    The diagnostic systems for Tandem Mirror Experiment-Upgrade (TMX-U) have grown from eleven initial systems to more than twenty systems. During operation, diagnostic system modifications are sometimes required to complete experimental objectives. Also, during operations new diagnostic systems are being developed and implemented. To ensure and maintain the quality and integrity of the data signals, a set of plans and systematic actions are being developed. This paper reviews the procedures set in place to maintain the integrity of existing data systems and ensure the performance objectives of new diagnostics being added

  18. Foucauldian diagnostics: space, time, and the metaphysics of medicine.

    Science.gov (United States)

    Bishop, Jeffrey P

    2009-08-01

    This essay places Foucault's work into a philosophical context, recognizing that Foucault is difficult to place and demonstrates that Foucault remains in the Kantian tradition of philosophy, even if he sits at the margins of that tradition. For Kant, the forms of intuition-space and time-are the a priori conditions of the possibility of human experience and knowledge. For Foucault, the a priori conditions are political space and historical time. Foucault sees political space as central to understanding both the subject and objects of medicine, psychiatry, and the social sciences. Through this analysis one can see that medicine's metaphysics is a metaphysics of efficient causation, where medicine's objects are subjected to mechanisms of efficient control.

  19. SOCIAL INTEGRATION: TESTING ANTECEDENTS OF TIME SPENT ONLINE

    Directory of Open Access Journals (Sweden)

    Lily Suriani Mohd Arif

    2013-07-01

    Full Text Available The literature on the relationship of social integration and time spent onlineprovides conflicting evidence of the relationship of social integration with timespent online. The study identifies and highlightsthe controversy and attempts toclarify the relationship of social integration withtime spent online bydecomposing the construct social integration into its affective and behavioraldimensions . Thestudy tests antecedents and effects of time spent online in arandom sample of senior level undergraduate students at a public university inMalaysia. The findings indicated that while self-report measures of behavioralsocial integration did not predict time spent online, and, the affective socialintegration had an inverse relationship with time spent online.

  20. Whole exome sequencing in neurogenetic odysseys: An effective, cost- and time-saving diagnostic approach.

    Directory of Open Access Journals (Sweden)

    Marta Córdoba

    Full Text Available Diagnostic trajectories for neurogenetic disorders frequently require the use of considerable time and resources, exposing patients and families to so-called "diagnostic odysseys". Previous studies have provided strong evidence for increased diagnostic and clinical utility of whole-exome sequencing in medical genetics. However, specific reports assessing its utility in a setting such as ours- a neurogeneticist led academic group serving in a low-income country-are rare.To assess the diagnostic yield of WES in patients suspected of having a neurogenetic condition and explore the cost-effectiveness of its implementation in a research group located in an Argentinean public hospital.This is a prospective study of the clinical utility of WES in a series of 40 consecutive patients selected from a Neurogenetic Clinic of a tertiary Hospital in Argentina. We evaluated patients retrospectively for previous diagnostic trajectories. Diagnostic yield, clinical impact on management and economic diagnostic burden were evaluated.We demonstrated the clinical utility of Whole Exome Sequencing in our patient cohort, obtaining a diagnostic yield of 40% (95% CI, 24.8%-55.2% among a diverse group of neurological disorders. The average age at the time of WES was 23 (range 3-70. The mean time elapsed from symptom onset to WES was 11 years (range 3-42. The mean cost of the diagnostic workup prior to WES was USD 1646 (USD 1439 to 1853, which is 60% higher than WES cost in our center.WES for neurogenetics proved to be an effective, cost- and time-saving approach for the molecular diagnosis of this heterogeneous and complex group of patients.

  1. Spectral and Timing Diagnostics of Accretion in XRBs

    Science.gov (United States)

    Nowak, M. N.

    One of the truly great advantages of the Rossi X-ray Timing Explorer has been its flexible scheduling coupled with the presence of the All Sky Monitor. This has allowed mutliple observations of given objects over a wide range of luminosities that, thanks to the ASM, can be placed within the context of the overall behavior of the source. This has begun to allow us to develop theories of how the accretion flow in black hole candidates changes as a function of state and accretion rate. A number of spectral and temporal correlations have been seen, others have merely been suggested as being probably or possible. In this talk I will review some of these suggestions, and outline those correlations that I think are firm and contrast them to those that I believe are still very speculative. I will discuss these observations in the context of suggested models for the structure, size scale, and dynamics of the accretion flow.

  2. Integrated watershed analysis: adapting to changing times

    Science.gov (United States)

    Gordon H. Reeves

    2013-01-01

    Resource managers are increasingly required to conduct integrated analyses of aquatic and terrestrial ecosystems before undertaking any activities. Th ere are a number of research studies on the impacts of management actions on these ecosystems, as well as a growing body of knowledge about ecological processes that aff ect them, particularly aquatic ecosystems, which...

  3. Minimizing time for test in integrated circuit

    OpenAIRE

    Andonova, A. S.; Dimitrov, D. G.; Atanasova, N. G.

    2004-01-01

    The cost for testing integrated circuits represents a growing percentage of the total cost for their production. The former strictly depends on the length of the test session, and its reduction has been the target of many efforts in the past. This paper proposes a new method for reducing the test length by adopting a new architecture and exploiting an evolutionary optimisation algorithm. A prototype of the proposed approach was tested on 1SCAS standard benchmarks and theexperimental results s...

  4. CEA engineering studies and integration of the ITER diagnostic port plugs

    International Nuclear Information System (INIS)

    Doceul, L.; Walker, C.; Ingesson, C.; Ciattaglia, E.; Chappuis, P.; Portafaix, C.; Salasca, S.; Thomas, E.; Tremblay, G.; Bruyere, C.

    2007-01-01

    Most of the ITER diagnostic system is integrated in port plugs, which are water cooled stainless steel structures inserted into the vacuum-vessel ports. The port plug must perform basic functions such as providing neutron and gamma shielding, supporting the first wall armour and shielding blanket material, closing the vacuum vessel ports, while supporting the diagnostic equipment. CEA has contributed to the engineering activities on the port plugs and has more particularly focused on the design and diagnostic integration in the representative equatorial port plug Eq no. 01. The specific CEA contributions have been the engineering, structural and thermal analysis. These detailed analyses have highlighted some design issues which were worked out through different solutions. This paper contains a description of the engineering activities performed such as: the conceptual design of the Eq no. 01 port plug, the static mechanical calculations, the dynamic calculation to estimate the dynamic amplification factor due to the resonance phenomenon, the thermal assessment under the neutronic load and the seismic response of the port plug inside the vacuum vessel

  5. CEA engineering studies and integration of the ITER diagnostic port plugs

    Energy Technology Data Exchange (ETDEWEB)

    Doceul, L. [Association Euratom-CEA sur la Fusion Controlee, Centre d' Etudes de Cadarache, F-13108 Saint-Paul-Lez-Durance Cedex (France)], E-mail: louis.doceul@cea.fr; Walker, C. [ITER International Team, Boltzmannstr. 2, D-85748 Garching bei Muenchen (Germany); Ingesson, C.; Ciattaglia, E. [EFDA CSU - Garching, Boltzmannstr. 2, D-85748 Garching bei Muenchen (Germany); Chappuis, P.; Portafaix, C.; Salasca, S.; Thomas, E.; Tremblay, G.; Bruyere, C. [Association Euratom-CEA sur la Fusion Controlee, Centre d' Etudes de Cadarache, F-13108 Saint-Paul-Lez-Durance Cedex (France)

    2007-10-15

    Most of the ITER diagnostic system is integrated in port plugs, which are water cooled stainless steel structures inserted into the vacuum-vessel ports. The port plug must perform basic functions such as providing neutron and gamma shielding, supporting the first wall armour and shielding blanket material, closing the vacuum vessel ports, while supporting the diagnostic equipment. CEA has contributed to the engineering activities on the port plugs and has more particularly focused on the design and diagnostic integration in the representative equatorial port plug Eq no. 01. The specific CEA contributions have been the engineering, structural and thermal analysis. These detailed analyses have highlighted some design issues which were worked out through different solutions. This paper contains a description of the engineering activities performed such as: the conceptual design of the Eq no. 01 port plug, the static mechanical calculations, the dynamic calculation to estimate the dynamic amplification factor due to the resonance phenomenon, the thermal assessment under the neutronic load and the seismic response of the port plug inside the vacuum vessel.

  6. Implementation of an integrated on-line process surveillance and diagnostic system at the Halden reactor project: MOAS

    International Nuclear Information System (INIS)

    Kim, I.S.; Grini, R.-E.; Nilsen, S.

    2001-01-01

    MOAS is an integrated on-line process surveillance and diagnostic system that uses several different models for knowledge acquisition and diagnostic reasoning, such as goal-tree success-tree model, process monitor trees, and sensor failure diagnosis trees. Within these models, the knowledge of the process and its operation, including deep knowledge, like mass balance or controller algorithm, is incorporated. During an extensive review, made as part of the integrated diagnosis system project of the Halden reactor project, MOAS (Maryland Operator Advisory System) was identified as one of the most thorough systems developed thus far. MOAS encompasses diverse functional aspects that are required for an effective process disturbance management: (1) intelligent process monitoring and alarming, (2) on-line sensor data validation and sensor failure diagnosis, (3) on-line hardware (besides sensors) failure diagnosis, and (4) real-time corrective measure synthesis. The MOAS methodology was used for the NORS (Nokia Research Simulator) process at the Halden man-machine laboratory HAMMLAB of the OECD Halden reactor project. The performance tests of MOAS, implemented in G2 real-time expert system shell, show that MOAS successfully carries out its intended functions, i.e. quickly recognizing an occurring disturbance, correctly diagnosing its cause, and presenting advice on its control to the operator. The lessons learned and insights gained during the implementation and performance tests also are discussed

  7. Integrating Nursing Diagnostic Concepts into the Medical Entities Dictionary Using the ISO Reference Terminology Model for Nursing Diagnosis

    OpenAIRE

    Hwang, Jee-In; Cimino, James J.; Bakken, Suzanne

    2003-01-01

    Objective: The purposes of the study were (1) to evaluate the usefulness of the International Standards Organization (ISO) Reference Terminology Model for Nursing Diagnoses as a terminology model for defining nursing diagnostic concepts in the Medical Entities Dictionary (MED) and (2) to create the additional hierarchical structures required for integration of nursing diagnostic concepts into the MED.

  8. Ecotoxicology and macroecology – Time for integration

    International Nuclear Information System (INIS)

    Beketov, Mikhail A.; Liess, Matthias

    2012-01-01

    Despite considerable progress in ecotoxicology, it has become clear that this discipline cannot answer its central questions, such as, “What are the effects of toxicants on biodiversity?” and “How the ecosystem functions and services are affected by the toxicants?”. We argue that if such questions are to be answered, a paradigm shift is needed. The current bottom-up approach of ecotoxicology that implies the use of small-scale experiments to predict effects on the entire ecosystems and landscapes should be merged with a top-down macroecological approach that is directly focused on ecological effects at large spatial scales and consider ecological systems as integral entities. Analysis of the existing methods in ecotoxicology, ecology, and environmental chemistry shows that such integration is currently possible. Therefore, we conclude that to tackle the current pressing challenges, ecotoxicology has to progress using both the bottom-up and top-down approaches, similar to digging a tunnel from both ends at once. - To tackle the current pressing challenges, ecotoxicology has to progress using both the bottom-up experimental and top-down observational approaches.

  9. Development of an integrated condition monitoring and diagnostic system for motor-operated valves used in nuclear power plant

    International Nuclear Information System (INIS)

    Carneiro, Alvaro Luiz Guimaraes

    2003-01-01

    The reliability question of the components, specifically of motor operated valves, became one of the most important issues to be investigated in nuclear power plants, considering security and life plant extension. Therefore, the necessity of improvements in monitoring and diagnosis methods started to be of extreme relevance in the maintenance predictive field, establishing as main goal the reliability and readiness of the system components. Specially in nuclear power plants, the predictive maintenance contributes in the security factor in order to diagnosis in advance the occurrence of a possible failure, preventing severe situations. It also presents a contribution on the economic side by establishing a better maintenance programming, and reducing unexpected shutdown. The development of non intrusive monitoring and diagnostic method makes it possible to identify malfunctions in plant components during normal plant operation. This dissertation presents the development of an integrated condition monitoring system for motor-operated valves used in nuclear power plants. The methodology used in this project is based on the electric motor power signatures analysis, during the closing and opening stroke time of the valve. Once the measurements baseline diagnostic of the motor-operated valve is taken, it is possible to detect long-term deviations during valve lifetime, detecting in advance valve failures. The system implements two parallel techniques for detection and categorization of anomalies: expert system using fuzzy logic based on rules and knowledge base, providing a systematic approach for decision making, and the Wavelet Transform Technique, where the main goal is to obtain more detailed information contained in the measured data, identifying and characterizing the transients phenomena in the time and frequency domains, correlating them to failures situations in the incipient stage. The conditioning monitoring and diagnostic system was designed and implemented at

  10. Optimized acoustic biochip integrated with microfluidics for biomarkers detection in molecular diagnostics.

    Science.gov (United States)

    Papadakis, G; Friedt, J M; Eck, M; Rabus, D; Jobst, G; Gizeli, E

    2017-09-01

    The development of integrated platforms incorporating an acoustic device as the detection element requires addressing simultaneously several challenges of technological and scientific nature. The present work was focused on the design of a microfluidic module, which, combined with a dual or array type Love wave acoustic chip could be applied to biomedical applications and molecular diagnostics. Based on a systematic study we optimized the mechanics of the flow cell attachment and the sealing material so that fluidic interfacing/encapsulation would impose minimal losses to the acoustic wave. We have also investigated combinations of operating frequencies with waveguide materials and thicknesses for maximum sensitivity during the detection of protein and DNA biomarkers. Within our investigations neutravidin was used as a model protein biomarker and unpurified PCR amplified Salmonella DNA as the model genetic target. Our results clearly indicate the need for experimental verification of the optimum engineering and analytical parameters, in order to develop commercially viable systems for integrated analysis. The good reproducibility of the signal together with the ability of the array biochip to detect multiple samples hold promise for the future use of the integrated system in a Lab-on-a-Chip platform for application to molecular diagnostics.

  11. Quality control in diagnostic immunohistochemistry: integrated on-slide positive controls.

    Science.gov (United States)

    Bragoni, A; Gambella, A; Pigozzi, S; Grigolini, M; Fiocca, R; Mastracci, L; Grillo, F

    2017-11-01

    Standardization in immunohistochemistry is a priority in modern pathology and requires strict quality control. Cost containment has also become fundamental and auditing of all procedures must take into account both these principles. Positive controls must be routinely performed so that their positivity guarantees the appropriateness of the immunohistochemical procedure. The aim of this study is to develop a low cost (utilizing a punch biopsy-PB-tool) procedure to construct positive controls which can be integrated in the patient's tissue slide. Sixteen frequently used control blocks were selected and multiple cylindrical samples were obtained using a 5-mm diameter punch biopsy tool, separately re-embedding them in single blocks. For each diagnostic immunoreaction requiring a positive control, an integrated PB-control section (cut from the appropriate PB-control block) was added to the top right corner of the diagnostic slide before immunostaining. This integrated control technique permitted a saving of 4.75% in total direct lab costs and proved to be technically feasible and reliable. Our proposal is easy to perform and within the reach of all pathology labs, requires easily available tools, its application costs is less than using external paired controls and ensures that a specific control for each slide is always available.

  12. Advanced integrated real-time clinical displays.

    Science.gov (United States)

    Kruger, Grant H; Tremper, Kevin K

    2011-09-01

    Intelligent medical displays have the potential to improve patient outcomes by integrating multiple physiologic signals, exhibiting high sensitivity and specificity, and reducing information overload for physicians. Research findings have suggested that information overload and distractions caused by patient care activities and alarms generated by multiple monitors in acute care situations, such as the operating room and the intensive care unit, may produce situations that negatively impact the outcomes of patients under anesthesia. This can be attributed to shortcomings of human-in-the-loop monitoring and the poor specificity of existing physiologic alarms. Modern artificial intelligence techniques (ie, intelligent software agents) are demonstrating the potential to meet the challenges of next-generation patient monitoring and alerting. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Clinical utility of real-time compression ultrasonography for diagnostic management of patients with recurrent venous thrombosis

    NARCIS (Netherlands)

    Heijboer, H.; Jongbloets, L. M.; Büller, H. R.; Lensing, A. W.; ten Cate, J. W.

    1992-01-01

    In the diagnostic management of patients with clinically suspected recurrent deep-vein thrombosis (DVT), there are potential limitations to all available diagnostic techniques. Since venous abnormalities may persist for some time after an acute thrombosis, the usefulness of compression

  14. Diagnostic pathway of integrated SPECT/CT for coronary artery disease

    International Nuclear Information System (INIS)

    Slart, Riemer H.J.A.; Tio, Rene A.; Zijlstra, Felix; Dierckx, Rudi A.

    2009-01-01

    Treatment strategy in patients with suspected coronary artery disease (CAD) is driven by symptomatology in combination with diagnostic evaluation of the extent and/or severity of atherosclerosis in the coronary arteries and ischemia in the myocardium, i.e., the anatomic and functional correlates of CAD. Whereas multislice row computed tomography (MSCT) has the advantage of detecting coronary atherosclerosis at its earliest stages, thereby allowing initiation of appropriate therapeutic measures well before development of obstructive CAD, myocardial perfusion imaging (MPI) SPECT can clarify the hemodynamic consequences of the anatomic findings on MSCT based on a functional assessment of myocardial blood flow. There is a lack of correlation between coronary artery calcium (CAC), coronary artery stenosis, and MPI SPECT. Therefore CAC scoring and stress MPI should be thus considered complementary approaches rather than exclusionary in the evaluation of the patient at risk for CAD. The integration of anatomic and functional information may provide additional information for the clinician by the improved risk stratification and diagnostic accuracy of integrated techniques. The majority of previous studies are based on a sequential flowchart, starting with either SPECT or CAC scoring that finally directs the therapeutic strategy. Patients at low risk for CAD can be selected for primary prevention, and patients at high risk for CAD can be directly selected for coronary angiography (CAG). The remaining group of patients at intermediate risk for CAD can be substratified into lower- and higher-risk categories based on the presence or absence of stress-induced ischemia on MPI SPECT and CAC scoring. An integration of SPECT and CAC as a starting point for CAD detection in symptomatic patients at intermediate risk for CAD may facilitate a tailored diagnostic as well as therapeutic approach. Finally, using SPECT/CT, MPI SPECT, and CAC findings may be completed with CT angiography

  15. Condition monitoring and diagnostic systems integration - guiding principles and practical examples

    Energy Technology Data Exchange (ETDEWEB)

    Roverso, D.; Farbrot, J.E.; Gran, F.S.; Hoffmann, M.

    2005-08-15

    Recent years have seen a steady stream of new condition monitoring and diagnostic (CMD) systems and techniques being designed for applications in the nuclear industry. The HRP has been particularly active in this respect with the development of systems such as PEANO for on-line sensor calibration monitoring and aladdin for early fault detection and diagnosis. The availability at the HRP of a wide range of other Computerized Operations Support Systems as well as the availability of the HAMMLAB experimental control room has also allowed for the investigation of the range of issues related to the integration of such systems into control room settings. After a brief description of the development and application of these CMD systems, the report identifies three different levels of integration that should be taken into consideration. These are the data level, the operational level, and the functional level. The data level includes all aspects of data communication between the CMD system, the plant instrumentation, and the other computerized support systems present at the plant. The operational level includes all those aspects of integration that influence the way in which the operator interacts with the CMD system, with a clear emphasis on Human System Interface (HSI) integration. The functional level includes those aspects of integration that deal with the functionality of the CMD system and how this can support or be combined with the functionality offered by other support systems with the aim of exploiting synergistic effects and achieving new functions. Additionally, the report identifies a set of guiding principles of integration that can be applied at all three levels of integration. Case studies taken from experiences gathered at the HRP are used throughout the report to exemplify the identified integration principles. (Author)

  16. An integrated technique for developing real-time systems

    NARCIS (Netherlands)

    Hooman, J.J.M.; Vain, J.

    1995-01-01

    The integration of conceptual modeling techniques, formal specification, and compositional verification is considered for real time systems within the knowledge engineering context. We define constructive transformations from a conceptual meta model to a real time specification language and give

  17. Data acquisition and real time signal processing of plasma diagnostics on ASDEX Upgrade using LabVIEW RT

    Energy Technology Data Exchange (ETDEWEB)

    Giannone, L.; Scarabosio, A.; Eich, T.; Fuchs, C.; Haas, G.; Kallenbach, A.; McCarthy, P.; Mlynek, A.; Neu, G.; Reich, M.; Schneider, W.; Schuhbeck, K.; Treutterer, W.; Zehetbauer, T.; Asdex, Upgrade Team [Max-Planck-Institut fur Plasmaphysik, Garching (Germany); Cerna, M.; Wenzel, L.; Concezzi, S.; Debelle, T.; Marker, B.; Munroe, M.; Petersen, N.; Vrancic, A. [National Instruments Corporation, Austin (United States); Marquardt, M.; Sachtleben, J. [Max-Planck-Institute for Plasmaphysics, Teilinstitut Greifswald (Germany)

    2009-07-01

    There are 5 plasma diagnostics using LabVIEW RT for data acquisition and control on ASDEX Upgrade. These diagnostics are integrated into the VxWorks control system by the exchange of XML files. Real time communication to the control system is possible by Ethernet using UDP or by reflective memory using a dedicated fiber optic cable. The bolometer and manometer data acquisition systems are described, they use FPGA cards to process raw data in real time. The absorbed power of the bolometer foil is calculated in real time on the FPGA. The radiation peaking factor is also calculated in real time and is used for feedback control of the discharge. The manometer uses 8 analog inputs and 4 analog outputs of a FPGA card to provide PID control of the electron current emission of a filament. The electron and ion currents are acquired at 750 kHz and the neutral gas pressures of 4 manometers are calculated in real time on a FPGA card at up to 10 kHz. The magnetic equilibrium diagnostic acquires 80 magnetic probe and flux loop signals at 10 kHz. The 95 plasma position and shape parameters and magnetic flux surfaces are calculated in real time. The function parameterization algorithm used to calculate the magnetic flux surfaces in real time requires the multiplication of a matrix of dimension 2691*231 with a vector of length 231. This matrix and vector multiplication is solved through parallel computing on a dual quad-core computer and the execution time of this operation is reduced by a factor of four compared to calculation on a single core. This document is composed of an abstract followed by a poster. (authors)

  18. Real-time signal communication between diagnostic and control in ASDEX Upgrade

    International Nuclear Information System (INIS)

    Treutterer, Wolfgang; Neu, Gregor; Raupp, Gerhard; Zehetbauer, Thomas; Zasche, Dieter; Lueddecke, Klaus; Cole, Richard

    2010-01-01

    The ASDEX Upgrade tokamak experiment is equipped with a versatile discharge monitoring and control system. It allows to develop and use advanced control algorithms to investigate plasma physics under well-defined conditions with the objective of optimising plasma performance. The achievable quality depends on the accuracy with which the plasma state can be reconstructed from measurements under real-time conditions. Today's advanced algorithms need physics quantities - scalar entities as well as profiles. These are obtained processing huge numbers of raw measurements with complex diagnostic algorithms. Adequate network communication for the resulting signals is crucial to satisfy real-time requirements, especially when several diagnostic systems cooperate in a feedback control loop. Support for the technology of choice, however, is not easily available for all of the diverse, highly specialised diagnostic systems. We give an overview about the methods that have been explored at ASDEX Upgrade for real-time signal transfer. In particular, we investigated reflective shared memory and Ethernet technologies. Our solution strives to combine their strengths. For fast communication on dedicated computing nodes, reflective shared memory is used. For the majority of diagnostic systems producing large data blocks at moderate rates, Ethernet connections with UDP protocol are employed. Following ASDEX Upgrade's framework concept, a software layer hides the networks used from both diagnostic and control applications.

  19. Real-time signal communication between diagnostic and control in ASDEX Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, Wolfgang, E-mail: Wolfgang.Treutterer@ipp.mpg.d [Max-Planck Institut fuer Plasmaphysik, Garching, EURATOM Association (Germany); Neu, Gregor; Raupp, Gerhard; Zehetbauer, Thomas; Zasche, Dieter [Max-Planck Institut fuer Plasmaphysik, Garching, EURATOM Association (Germany); Lueddecke, Klaus; Cole, Richard [Unlimited Computer Systems, Iffeldorf (Germany)

    2010-07-15

    The ASDEX Upgrade tokamak experiment is equipped with a versatile discharge monitoring and control system. It allows to develop and use advanced control algorithms to investigate plasma physics under well-defined conditions with the objective of optimising plasma performance. The achievable quality depends on the accuracy with which the plasma state can be reconstructed from measurements under real-time conditions. Today's advanced algorithms need physics quantities - scalar entities as well as profiles. These are obtained processing huge numbers of raw measurements with complex diagnostic algorithms. Adequate network communication for the resulting signals is crucial to satisfy real-time requirements, especially when several diagnostic systems cooperate in a feedback control loop. Support for the technology of choice, however, is not easily available for all of the diverse, highly specialised diagnostic systems. We give an overview about the methods that have been explored at ASDEX Upgrade for real-time signal transfer. In particular, we investigated reflective shared memory and Ethernet technologies. Our solution strives to combine their strengths. For fast communication on dedicated computing nodes, reflective shared memory is used. For the majority of diagnostic systems producing large data blocks at moderate rates, Ethernet connections with UDP protocol are employed. Following ASDEX Upgrade's framework concept, a software layer hides the networks used from both diagnostic and control applications.

  20. Application of Choi—Williams Reduced Interference Time Frequency Distribution to Machinery Diagnostics

    Directory of Open Access Journals (Sweden)

    Howard A. Gaberson

    1995-01-01

    Full Text Available This article discusses time frequency analysis of machinery diagnostic vibration signals. The short time Fourier transform, the Wigner, and the Choi–Williams distributions are explained and illustrated with test cases. Examples of Choi—Williams analyses of machinery vibration signals are presented. The analyses detect discontinuities in the signals and their timing, amplitude and frequency modulation, and the presence of different components in a vibration signal.

  1. Exponential integrators in time-dependent density-functional calculations

    Science.gov (United States)

    Kidd, Daniel; Covington, Cody; Varga, Kálmán

    2017-12-01

    The integrating factor and exponential time differencing methods are implemented and tested for solving the time-dependent Kohn-Sham equations. Popular time propagation methods used in physics, as well as other robust numerical approaches, are compared to these exponential integrator methods in order to judge the relative merit of the computational schemes. We determine an improvement in accuracy of multiple orders of magnitude when describing dynamics driven primarily by a nonlinear potential. For cases of dynamics driven by a time-dependent external potential, the accuracy of the exponential integrator methods are less enhanced but still match or outperform the best of the conventional methods tested.

  2. Development of local oscillator integrated antenna array for microwave imaging diagnostics

    International Nuclear Information System (INIS)

    Kuwahara, D.; Shinohara, S.; Ito, N.; Nagayama, Y.; Tsuchiya, H.; Yoshikawa, M.; Kohagura, J.; Yoshinaga, T.; Yamaguchi, S.; Kogi, Y.; Mase, A.

    2015-01-01

    Microwave imaging diagnostics are powerful tools that are used to obtain details of complex structures and behaviors of such systems as magnetically confined plasmas. For example, microwave imaging reflectometry and microwave imaging interferometers are suitable for observing phenomena that are involved with electron density fluctuations; moreover, electron cyclotron emission imaging diagnostics enable us to accomplish the significant task of observing MHD instabilities in large tokamaks. However, microwave imaging systems include difficulties in terms of multi-channelization and cost. Recently, we solved these problems by developing a Horn-antenna Mixer Array (HMA), a 50 - 110 GHz 1-D heterodyne- type antenna array, which can be easily stacked as a 2-D receiving array, because it uses an end-fire element. However, the HMA still evidenced problems owing to the requirement for local oscillation (LO) optics and an expensive high-power LO source. To solve this problem, we have developed an upgraded HMA, named the Local Integrated Antenna array (LIA), in which each channel has an internal LO supply using a frequency multiplier integrated circuit. Therefore, the proposed antenna array eliminates the need for both the LO optics and the high-power LO source. This paper describes the principle of the LIA, and provides details about an 8 channel prototype LIA

  3. Engineering integrated digital circuits with allosteric ribozymes for scaling up molecular computation and diagnostics.

    Science.gov (United States)

    Penchovsky, Robert

    2012-10-19

    Here we describe molecular implementations of integrated digital circuits, including a three-input AND logic gate, a two-input multiplexer, and 1-to-2 decoder using allosteric ribozymes. Furthermore, we demonstrate a multiplexer-decoder circuit. The ribozymes are designed to seek-and-destroy specific RNAs with a certain length by a fully computerized procedure. The algorithm can accurately predict one base substitution that alters the ribozyme's logic function. The ability to sense the length of RNA molecules enables single ribozymes to be used as platforms for multiple interactions. These ribozymes can work as integrated circuits with the functionality of up to five logic gates. The ribozyme design is universal since the allosteric and substrate domains can be altered to sense different RNAs. In addition, the ribozymes can specifically cleave RNA molecules with triplet-repeat expansions observed in genetic disorders such as oculopharyngeal muscular dystrophy. Therefore, the designer ribozymes can be employed for scaling up computing and diagnostic networks in the fields of molecular computing and diagnostics and RNA synthetic biology.

  4. tavg1_2d_int_Nx: MERRA 2D IAU Diagnostic, Vertical Integrals and Budget Terms, Time Average 1-hourly 0.667 x 0.5 degree V5.2.0 (MAT1NXINT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXINT or tavg1_2d_int_Nx data product is the MERRA Data Assimilation System 2-Dimensional vertical integral that is time averaged single-level at the native...

  5. The Impact of Time-Series Diagnostic Tests on the Writing Ability of Iranian EFL Learners

    Science.gov (United States)

    Atashgahi, Bahareh Molazem

    2014-01-01

    This study aimed to show whether administering a battery of time-series diagnostic tests (screening) has any impact on Iranian EFL learners' writing ability. The study was conducted on the intermediate EFL learners at Islamic Azad University North Tehran branch. The researcher administered a homogenizing test in order to exclude the exceptional…

  6. Improving Music Genre Classification by Short-Time Feature Integration

    DEFF Research Database (Denmark)

    Meng, Anders; Ahrendt, Peter; Larsen, Jan

    2005-01-01

    Many different short-time features, using time windows in the size of 10-30 ms, have been proposed for music segmentation, retrieval and genre classification. However, often the available time frame of the music to make the actual decision or comparison (the decision time horizon) is in the range...... of seconds instead of milliseconds. The problem of making new features on the larger time scale from the short-time features (feature integration) has only received little attention. This paper investigates different methods for feature integration and late information fusion for music genre classification...

  7. Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic-resistant Gram-negative bacteremia.

    Science.gov (United States)

    Perez, Katherine K; Olsen, Randall J; Musick, William L; Cernoch, Patricia L; Davis, James R; Peterson, Leif E; Musser, James M

    2014-09-01

    An intervention for Gram-negative bloodstream infections that integrated mass spectrometry technology for rapid diagnosis with antimicrobial stewardship oversight significantly improved patient outcomes and reduced hospital costs. As antibiotic resistance rates continue to grow at an alarming speed, the current study was undertaken to assess the impact of this intervention in a challenging patient population with bloodstream infections caused by antibiotic-resistant Gram-negative bacteria. A total of 153 patients with antibiotic-resistant Gram-negative bacteremia hospitalized prior to the study intervention were compared to 112 patients treated post-implementation. Outcomes assessed included time to optimal antibiotic therapy, time to active treatment when inactive, hospital and intensive care unit length of stay, all-cause 30-day mortality, and total hospital expenditures. Integrating rapid diagnostics with antimicrobial stewardship improved time to optimal antibiotic therapy (80.9 h in the pre-intervention period versus 23.2 h in the intervention period, P Gram-negatives. The intervention decreased hospital and intensive care unit length of stay, total hospital costs, and reduced all-cause 30-day mortality. Copyright © 2014. Published by Elsevier Ltd.

  8. Time resolved spectroscopy of GRB 030501 using INTEGRAL

    DEFF Research Database (Denmark)

    Beckmann, V.; Borkowski, J.; Courvoisier, T.J.L.

    2003-01-01

    The gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst...... the Ulysses and RHESSI experiments....

  9. Time Varying Market Integration and Expected Rteurns in Emerging Markets

    NARCIS (Netherlands)

    de Jong, F.C.J.M.; de Roon, F.A.

    2001-01-01

    We use a simple model in which the expected returns in emerging markets depend on their systematic risk as measured by their beta relative to the world portfolio as well as on the level of integration in that market.The level of integration is a time-varying variable that depends on the market value

  10. Space-time transformations in radial path integrals

    International Nuclear Information System (INIS)

    Steiner, F.

    1984-09-01

    Nonlinear space-time transformations in the radial path integral are discussed. A transformation formula is derived, which relates the original path integral to the Green's function of a new quantum system with an effective potential containing an observable quantum correction proportional(h/2π) 2 . As an example the formula is applied to spherical Brownian motion. (orig.)

  11. Path integral solution for some time-dependent potential

    International Nuclear Information System (INIS)

    Storchak, S.N.

    1989-12-01

    The quantum-mechanical problem with a time-dependent potential is solved by the path integral method. The solution is obtained by the application of the previously derived general formula for rheonomic homogeneous point transformation and reparametrization in the path integral. (author). 4 refs

  12. An extended Halanay inequality of integral type on time scales

    Directory of Open Access Journals (Sweden)

    Boqun Ou

    2015-07-01

    Full Text Available In this paper, we obtain a Halanay-type inequality of integral type on time scales which improves and extends some earlier results for both the continuous and discrete cases. Several illustrative examples are also given.

  13. A CMOS integrated timing discriminator circuit for fast scintillation counters

    International Nuclear Information System (INIS)

    Jochmann, M.W.

    1998-01-01

    Based on a zero-crossing discriminator using a CR differentiation network for pulse shaping, a new CMOS integrated timing discriminator circuit is proposed for fast (t r ≥ 2 ns) scintillation counters at the cooler synchrotron COSY-Juelich. By eliminating the input signal's amplitude information by means of an analog continuous-time divider, a normalized pulse shape at the zero-crossing point is gained over a wide dynamic input amplitude range. In combination with an arming comparator and a monostable multivibrator this yields in a highly precise timing discriminator circuit, that is expected to be useful in different time measurement applications. First measurement results of a CMOS integrated logarithmic amplifier, which is part of the analog continuous-time divider, agree well with the corresponding simulations. Moreover, SPICE simulations of the integrated discriminator circuit promise a time walk well below 200 ps (FWHM) over a 40 dB input amplitude dynamic range

  14. Front-end data reduction of diagnostic signals by real-time digital filtering

    International Nuclear Information System (INIS)

    Zasche, D.; Fahrbach, H.U.; Harmeyer, E.

    1984-01-01

    Diagnostic measurements on a fusion plasma with high resolution in space, time and signal amplitude involve handling large amounts of data. In the design of the soft-X-ray pinhole camera diagnostic for JET (100 detectors in 2 cameras) a new approach to this problem was found. The analogue-to-digital conversion is performed continuously at the highest sample rate of 200 kHz, lower sample rates (10 kHz, 1 kHz, 100 Hz) are obtained by real-time digital filters which calculate weighted averages over consecutive samples and are undersampled at their outputs to reduce the data rate. At any time, the signals from all detectors are available at all possible data rates in ring buffers. The appropriate data rate can always be recorded on demand. (author)

  15. ICF implosion hotspot ion temperature diagnostic techniques based on neutron time-of-flight method

    International Nuclear Information System (INIS)

    Tang Qi; Song Zifeng; Chen Jiabin; Zhan Xiayu

    2013-01-01

    Ion temperature of implosion hotspot is a very important parameter for inertial confinement fusion. It reflects the energy level of the hotspot, and it is very sensitive to implosion symmetry and implosion speed. ICF implosion hotspot ion temperature diagnostic techniques based on neutron time-of-flight method were described. A neutron TOF spectrometer was developed using a ultrafast plastic scintillator as the neutron detector. Time response of the spectrometer has 1.1 ns FWHM and 0.5 ns rising time. TOF spectrum resolving method based on deconvolution and low pass filter was illuminated. Implosion hotspot ion temperature in low neutron yield and low ion temperature condition at Shenguang-Ⅲ facility was acquired using the diagnostic techniques. (authors)

  16. Model and Reduction of Inactive Times in a Maintenance Workshop Following a Diagnostic Error

    Directory of Open Access Journals (Sweden)

    T. Beda

    2011-04-01

    Full Text Available The majority of maintenance workshops in manufacturing factories are hierarchical. This arrangement permits quick response in advent of a breakdown. Reaction of the maintenance workshop is done by evaluating the characteristics of the breakdown. In effect, a diagnostic error at a given level of the process of decision making delays the restoration of normal operating state. The consequences are not just financial loses, but loss in customers’ satisfaction as well. The goal of this paper is to model the inactive time of a maintenance workshop in case that an unpredicted catalectic breakdown has occurred and a diagnostic error has also occurred at a certain level of decision-making, during the treatment process of the breakdown. We show that the expression for the inactive times obtained, is depended only on the characteristics of the workshop. Next, we propose a method to reduce the inactive times.

  17. Using recruitment source timing and diagnosticity to enhance applicants' occupation-specific human capital.

    Science.gov (United States)

    Campion, Michael C; Ployhart, Robert E; Campion, Michael A

    2017-05-01

    [Correction Notice: An Erratum for this article was reported in Vol 102(5) of Journal of Applied Psychology (see record 2017-14296-001). In the article, the following headings were inadvertently set at the wrong level: Method, Participants and Procedure, Measures, Occupation specific human capital, Symbolic jobs, Relevant majors, Occupation-specific capital hotspots, Source timing, Source diagnosticity, Results, and Discussion. All versions of this article have been corrected.] This study proposes that reaching applicants through more diagnostic recruitment sources earlier in their educational development (e.g., in high school) can lead them to invest more in their occupation-specific human capital (OSHC), thereby making them higher quality candidates. Using a sample of 78,157 applicants applying for jobs within a desirable professional occupation in the public sector, results indicate that applicants who report hearing about the occupation earlier, and applicants who report hearing about the occupation through more diagnostic sources, have higher levels of OSHC upon application. Additionally, source timing and diagnosticity affect the likelihood of candidates applying for jobs symbolic of the occupation, selecting relevant majors, and attending educational institutions with top programs related to the occupation. These findings suggest a firm's recruiting efforts may influence applicants' OSHC investment strategies. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. Synthetic radiation diagnostics in PIConGPU. Integrating spectral detectors into particle-in-cell codes

    Energy Technology Data Exchange (ETDEWEB)

    Pausch, Richard; Burau, Heiko; Huebl, Axel; Steiniger, Klaus [Helmholtz-Zentrum Dresden-Rossendorf (Germany); Technische Universitaet Dresden (Germany); Debus, Alexander; Widera, Rene; Bussmann, Michael [Helmholtz-Zentrum Dresden-Rossendorf (Germany)

    2016-07-01

    We present the in-situ far field radiation diagnostics in the particle-in-cell code PIConGPU. It was developed to close the gap between simulated plasma dynamics and radiation observed in laser plasma experiments. Its predictive capabilities, both qualitative and quantitative, have been tested against analytical models. Now, we apply this synthetic spectral diagnostics to investigate plasma dynamics in laser wakefield acceleration, laser foil irradiation and plasma instabilities. Our method is based on the far field approximation of the Lienard-Wiechert potential and allows predicting both coherent and incoherent radiation spectrally from infrared to X-rays. Its capability to resolve the radiation polarization and to determine the temporal and spatial origin of the radiation enables us to correlate specific spectral signatures with characteristic dynamics in the plasma. Furthermore, its direct integration into the highly-scalable GPU framework of PIConGPU allows computing radiation spectra for thousands of frequencies, hundreds of detector positions and billions of particles efficiently. In this talk we will demonstrate these capabilities on resent simulations of laser wakefield acceleration (LWFA) and high harmonics generation during target normal sheath acceleration (TNSA).

  19. Development of real time diagnostics and feedback algorithms for JET in view of the next step

    International Nuclear Information System (INIS)

    Murari, A.; Felton, R.; Zabeo, L.; Piccolo, F.; Sartori, F.; Murari, A.; Barana, O.; Albanese, R.; Joffrin, E.; Mazon, D.; Laborde, L.; Moreau, D.; Arena, P.; Bruno, M.; Ambrosino, G.; Ariola, M.; Crisanti, F.; Luna, E. de la; Sanchez, J.

    2004-01-01

    Real time control of many plasma parameters will be an essential aspect in the development of reliable high performance operation of Next Step Tokamaks. The main prerequisites for any feedback scheme are the precise real-time determination of the quantities to be controlled, requiring top quality and highly reliable diagnostics, and the availability of robust control algorithms. A new set of real time diagnostics was recently implemented on JET to prove the feasibility of determining, with high accuracy and time resolution, the most important plasma quantities. With regard to feedback algorithms, new model-based controllers were developed to allow a more robust control of several plasma parameters. Both diagnostics and algorithms were successfully used in several experiments, ranging from H-mode plasmas to configuration with internal transport barriers. Since elaboration of computationally heavy measurements is often required, significant attention was devoted to non-algorithmic methods like Digital or Cellular Neural/Nonlinear Networks. The real time hardware and software adopted architectures are also described with particular attention to their relevance to ITER. (authors)

  20. Development of real time diagnostics and feedback algorithms for JET in view of the next step

    International Nuclear Information System (INIS)

    Murari, A.; Barana, O.; Murari, A.; Felton, R.; Zabeo, L.; Piccolo, F.; Sartori, F.; Joffrin, E.; Mazon, D.; Laborde, L.; Moreau, D.; Albanese, R.; Arena, P.; Bruno, M.; Ambrosino, G.; Ariola, M.; Crisanti, F.; Luna, E. de la; Sanchez, J.

    2004-01-01

    Real time control of many plasma parameters will be an essential aspect in the development of reliable high performance operation of Next Step Tokamaks. The main prerequisites for any feedback scheme are the precise real-time determination of the quantities to be controlled, requiring top quality and highly reliable diagnostics, and the availability of robust control algorithms. A new set of real time diagnostics was recently implemented on JET to prove the feasibility of determining, with high accuracy and time resolution, the most important plasma quantities. With regard to feedback algorithms, new model-based controllers were developed to allow a more robust control of several plasma parameters. Both diagnostics and algorithms were successfully used in several experiments, ranging from H-mode plasmas to configuration with ITBs (internal thermal barriers). Since elaboration of computationally heavy measurements is often required, significant attention was devoted to non-algorithmic methods like Digital or Cellular Neural/Nonlinear Networks. The real time hardware and software adopted architectures are also described with particular attention to their relevance to ITER. (authors)

  1. Development of real time diagnostics and feedback algorithms for JET in view of the next step

    Energy Technology Data Exchange (ETDEWEB)

    Murari, A.; Barana, O. [Consorzio RFX Associazione EURATOM ENEA per la Fusione, Corso Stati Uniti 4, Padua (Italy); Felton, R.; Zabeo, L.; Piccolo, F.; Sartori, F. [Euratom/UKAEA Fusion Assoc., Culham Science Centre, Abingdon, Oxon (United Kingdom); Joffrin, E.; Mazon, D.; Laborde, L.; Moreau, D. [Association EURATOM-CEA, CEA Cadarache, 13 - Saint-Paul-lez-Durance (France); Albanese, R. [Assoc. Euratom-ENEA-CREATE, Univ. Mediterranea RC (Italy); Arena, P.; Bruno, M. [Assoc. Euratom-ENEA-CREATE, Univ.di Catania (Italy); Ambrosino, G.; Ariola, M. [Assoc. Euratom-ENEA-CREATE, Univ. Napoli Federico Napoli (Italy); Crisanti, F. [Associazone EURATOM ENEA sulla Fusione, C.R. Frascati (Italy); Luna, E. de la; Sanchez, J. [Associacion EURATOM CIEMAT para Fusion, Madrid (Spain)

    2004-07-01

    Real time control of many plasma parameters will be an essential aspect in the development of reliable high performance operation of Next Step Tokamaks. The main prerequisites for any feedback scheme are the precise real-time determination of the quantities to be controlled, requiring top quality and highly reliable diagnostics, and the availability of robust control algorithms. A new set of real time diagnostics was recently implemented on JET to prove the feasibility of determining, with high accuracy and time resolution, the most important plasma quantities. With regard to feedback algorithms, new model-based controllers were developed to allow a more robust control of several plasma parameters. Both diagnostics and algorithms were successfully used in several experiments, ranging from H-mode plasmas to configuration with ITBs (internal thermal barriers). Since elaboration of computationally heavy measurements is often required, significant attention was devoted to non-algorithmic methods like Digital or Cellular Neural/Nonlinear Networks. The real time hardware and software adopted architectures are also described with particular attention to their relevance to ITER. (authors)

  2. Precise digital integration in wide time range: theory and realization

    International Nuclear Information System (INIS)

    Batrakov, A.M.; Pavlenko, A.V.

    2017-01-01

    The digital integration method based on using high-speed precision analog-to-digital converters (ADC) has become widely used over the recent years. The paper analyzes the limitations of this method that are caused by the signal properties, ADC sampling rate and noise spectral density of the ADC signal path. This analysis allowed creating digital integrators with accurate synchronization and achieving an integration error of less than 10 −5 in the time range from microseconds to tens of seconds. The structure of the integrator is described and its basic parameters are presented. The possibilities of different ADC chips in terms of their applicability to digital integrators are discussed. A comparison with other integrating devices is presented.

  3. Integration of artificial intelligence systems for nuclear power plants surveillance and diagnostics

    International Nuclear Information System (INIS)

    Chetry, Moon K.

    2012-01-01

    The objective of this program is to design, construct operate, test, and evaluate a prototype integrated monitoring and diagnostic system for a nuclear power plant. It is anticipated that this technology will have wide application to other complex systems (e.g., fossil power plants, chemical processing plants, and possibly air traffic control systems). Over the past decade, the University of Tennessee (UT) and others have carried out many projects utilizing various methodologies of artificial intelligence (expert systems, neural networks, fuzzy systems and genetic algorithms) to enhance the performance (safety, efficiency, reliability, and availability) of nuclear power plants. Investigations and studies have included a) instrumentation surveillance and calibration validation, b) inferential sensing to calibration of feed water venture flow during fouling, c) thermodynamic performance modeling with iterative improvement of plant heat rate, d) diagnosis of nuclear power plant transients

  4. Patients' experiences and care needs during the diagnostic phase of an Integrated Brain Cancer Pathway

    DEFF Research Database (Denmark)

    Vedelø, Tina Wang; Sørensen, Jens Christian Hedemann; Delmar, Charlotte

    2018-01-01

    of brain cancer, not knowing what to expect and participants' perceptions of the relationship with the health care providers. The analysis revealed that participants were in risk of having unmet information needs and that contextual factors seemed to cause fragmented care that led to feelings...... that the shock of the diagnosis, combined with the multiple symptoms, affect patients' ability to understand information and express needs of care and support. Unmet needs have been reported within this group of patients, however, the experiences and care needs of patients going through the diagnostic phase...... of a standardised Integrated Brain Cancer Pathway have not previously been explored. DESIGN: A Case Study design was used to provide detailed information of the complex needs of patients being diagnosed with a malignant brain tumour. METHODS: Research interviews and direct participant observation of four patients...

  5. Development of time-resolved optical measurement and diagnostic system for parameters of high current and pulsed electron beam

    International Nuclear Information System (INIS)

    Jiang Xiaoguo; Wang Yuan; Yang Guojun; Xia Liansheng; Li Hong; Zhang Zhuo; Liao Shuqing; Shi Jinshui

    2013-01-01

    The beam parameters measurement is the most important work for the study of linear induction accelerator(LIA). The beam parameters are important to evaluate the character of the beam. The demands of beam parameters measurement are improving while the development of accelerator is improving. The measurement difficulty feature higher time-resolved ability, higher spatial resolution, larger dynamic range and higher intuitionistic view data. The measurement technology of beam spot, beam emittance, beam energy have been developed for the past several years. Some high performance equipment such as high speed framing camera are developed recently. Under this condition, the relative integrated optical measurement and diagnostic system for the beam parameters is developed based on several principles. The system features time-resolved ability of up to 2 ns, high sensitivity and large dynamic range. The processing program is compiled for the data process and the local real-time process is reached. The measurement and diagnostic system has provided full and accurate data for the debug work and has been put into applications. (authors)

  6. Integration of MDSplus in real-time systems

    International Nuclear Information System (INIS)

    Luchetta, A.; Manduchi, G.; Taliercio, C.

    2006-01-01

    RFX-mod makes extensive usage of real-time systems for feedback control and uses MDSplus to interface them to the main Data Acquisition system. For this purpose, the core of MDSplus has been ported to VxWorks, the operating system used for real-time control in RFX. Using this approach, it is possible to integrate real-time systems, but MDSplus is used only for non-real-time tasks, i.e. those tasks which are executed before and after the pulse and whose performance does not affect the system time constraints. More extensive use of MDSplus in real-time systems is foreseen, and a real-time layer for MDSplus is under development, which will provide access to memory-mapped pulse files, shared by the tasks running on the same CPU. Real-time communication will also be integrated in the MDSplus core to provide support for distributed memory-mapped pulse files

  7. Integrals of Motion for Discrete-Time Optimal Control Problems

    OpenAIRE

    Torres, Delfim F. M.

    2003-01-01

    We obtain a discrete time analog of E. Noether's theorem in Optimal Control, asserting that integrals of motion associated to the discrete time Pontryagin Maximum Principle can be computed from the quasi-invariance properties of the discrete time Lagrangian and discrete time control system. As corollaries, results for first-order and higher-order discrete problems of the calculus of variations are obtained.

  8. Building a satellite climate diagnostics data base for real-time climate monitoring

    International Nuclear Information System (INIS)

    Ropelewski, C.F.

    1991-01-01

    The paper discusses the development of a data base, the Satellite Climate Diagnostic Data Base (SCDDB), for real time operational climate monitoring utilizing current satellite data. Special attention is given to the satellite-derived quantities useful for monitoring global climate changes, the requirements of SCDDB, and the use of conventional meteorological data and model assimilated data in developing the SCDDB. Examples of prototype SCDDB products are presented. 10 refs

  9. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis.

    Science.gov (United States)

    Utzinger, Jürg; N'goran, Eliézer K; Caffrey, Conor R; Keiser, Jennifer

    2011-09-01

    Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease. Schistosomiasis, perhaps more than any other disease, is entrenched in prevailing social-ecological systems, since transmission is governed by human behaviour (e.g. open defecation and patterns of unprotected surface water contacts) and ecological features (e.g. living in close proximity to suitable freshwater bodies in which intermediate host snails proliferate). Moreover, schistosomiasis is intimately linked with poverty and the disease has spread to previously non-endemic areas as a result of demographic, ecological and engineering transformations. Importantly though, thanks to increased advocacy there is growing awareness, financial and technical support to control and eventually eliminate schistosomiasis as a public health problem at local, regional and global scales. The purpose of this review is to highlight recent progress made in innovation, validation and application of new tools and strategies for research and integrated control of schistosomiasis. First, we explain that schistosomiasis is deeply embedded in social-ecological systems and explore linkages with poverty. We then summarize and challenge global statistics, risk maps and burden estimates of human schistosomiasis. Discovery and development research pertaining to novel diagnostics and drugs forms the centrepiece of our review. We discuss unresolved issues and emerging opportunities for integrated and sustainable control of schistosomiasis and conclude with a series of research needs. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. Integration of artificial intelligence systems for nuclear power plant surveillance and diagnostics

    International Nuclear Information System (INIS)

    Uhrig, R.E.; Hines, J.W.; Nelson, W.R.

    1998-01-01

    The objective of this program is to design, construct, operate, test, and evaluate a prototype integrated monitoring and diagnostic system for a nuclear power plant. It is anticipated that this technology will have wide application to other complex systems (e.g., fossil power plants, chemical processing plants, and possibly air traffic control systems). Over the past decade, the University of Tennessee (UT) and others have carried out many projects utilizing various methodologies of artificial intelligence (expert systems, neural networks, fuzzy systems, and genetic algorithms) to enhance the performance (safety, efficiency, reliability, and availability) of nuclear power plants. Investigations and studies have included a) instrumentation surveillance and calibration validation, b) inferential sensing to calibration of feedwater venturi flow during fouling, c) thermodynamic performance modeling with iterative improvement of plant beat rate, d) diagnosis of nuclear power plant transients, and e) increase in thermal power through monitoring of DNBR (Departure from Nucleate Boiling Regime). To increase the likelihood of these individual systems being used in a nuclear power plant, they must be integrated into a single system that operates virtually autonomously, collecting, interpreting, and providing information to the operators in a simple and understandable format. (author)

  11. Integration of artificial intelligence systems for nuclear power plant surveillance and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Uhrig, R.E.; Hines, J.W.; Nelson, W.R.

    1998-07-01

    The objective of this program is to design, construct, operate, test, and evaluate a prototype integrated monitoring and diagnostic system for a nuclear power plant. It is anticipated that this technology will have wide application to other complex systems (e.g., fossil power plants, chemical processing plants, and possibly air traffic control systems). Over the past decade, the University of Tennessee (UT) and others have carried out many projects utilizing various methodologies of artificial intelligence (expert systems, neural networks, fuzzy systems, and genetic algorithms) to enhance the performance (safety, efficiency, reliability, and availability) of nuclear power plants. Investigations and studies have included a) instrumentation surveillance and calibration validation, b) inferential sensing to calibration of feedwater venturi flow during fouling, c) thermodynamic performance modeling with iterative improvement of plant beat rate, d) diagnosis of nuclear power plant transients, and e) increase in thermal power through monitoring of DNBR (Departure from Nucleate Boiling Regime). To increase the likelihood of these individual systems being used in a nuclear power plant, they must be integrated into a single system that operates virtually autonomously, collecting, interpreting, and providing information to the operators in a simple and understandable format. (author)

  12. Reclassification of Mixed Oligoastrocytic Tumors Using a Genetically Integrated Diagnostic Approach

    Directory of Open Access Journals (Sweden)

    Seong-Ik Kim

    2018-01-01

    Full Text Available Background Mixed gliomas, such as oligoastrocytomas (OA, anaplastic oligoastrocytomas, and glioblastomas (GBMs with an oligodendroglial component (GBMO are defined as tumors composed of a mixture of two distinct neoplastic cell types, astrocytic and oligodendroglial. Recently, mutations ATRX and TP53, and codeletion of 1p/19q are shown to be genetic hallmarks of astrocytic and oligodendroglial tumors, respectively. Subsequent molecular analyses of mixed gliomas preferred the reclassification to either oligodendroglioma or astrocytoma. This study was designed to apply genetically integrated diagnostic criteria to mixed gliomas and determine usefulness and prognostic value of new classification in Korean patients. Methods Fifty-eight cases of mixed OAs and GBMOs were retrieved from the pathology archives of Seoul National University Hospital from 2004 to 2015. Reclassification was performed according to genetic and immunohistochemical properties. Clinicopathological characteristics of each subgroup were evaluated. Overall survival was assessed and compared between subgroups. Results We could reclassify all mixed OAs and GBMOs into either astrocytic or oligodendroglial tumors. Notably, 29 GBMOs could be reclassified into 11 cases of GBM, IDH-mutant, 16 cases of GBM, IDH-wildtype, and two cases of anaplastic oligodendroglioma, IDH mutant. Overall survival was significantly different among these new groups (p<.001. Overall survival and progression-free survival were statistically better in gliomas with IDH mutation, ATRX mutation, no microscopic necrosis, and young patient age (cut off, 45 years old. Conclusions Our results strongly suggest that a genetically integrated diagnosis of glioma better reflects prognosis than former morphology-based methods.

  13. Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics.

    Science.gov (United States)

    Lutz, Barry; Liang, Tinny; Fu, Elain; Ramachandran, Sujatha; Kauffman, Peter; Yager, Paul

    2013-07-21

    Lateral flow tests (LFTs) are an ingenious format for rapid and easy-to-use diagnostics, but they are fundamentally limited to assay chemistries that can be reduced to a single chemical step. In contrast, most laboratory diagnostic assays rely on multiple timed steps carried out by a human or a machine. Here, we use dissolvable sugar applied to paper to create programmable flow delays and present a paper network topology that uses these time delays to program automated multi-step fluidic protocols. Solutions of sucrose at different concentrations (10-70% of saturation) were added to paper strips and dried to create fluidic time delays spanning minutes to nearly an hour. A simple folding card format employing sugar delays was shown to automate a four-step fluidic process initiated by a single user activation step (folding the card); this device was used to perform a signal-amplified sandwich immunoassay for a diagnostic biomarker for malaria. The cards are capable of automating multi-step assay protocols normally used in laboratories, but in a rapid, low-cost, and easy-to-use format.

  14. The Role of Memory and Integration in Early Time Concepts.

    Science.gov (United States)

    Levin, Iris; And Others

    1984-01-01

    A total of 630 boys and girls from kindergarten to second grade were asked to compare durations that differ in beginning times with those that differ in ending times. Possible sources of children's failure to integrate beginning and end points when comparing durations were discussed. (Author/CI)

  15. Frame-Transfer Gating Raman Spectroscopy for Time-Resolved Multiscalar Combustion Diagnostics

    Science.gov (United States)

    Nguyen, Quang-Viet; Fischer, David G.; Kojima, Jun

    2011-01-01

    Accurate experimental measurement of spatially and temporally resolved variations in chemical composition (species concentrations) and temperature in turbulent flames is vital for characterizing the complex phenomena occurring in most practical combustion systems. These diagnostic measurements are called multiscalar because they are capable of acquiring multiple scalar quantities simultaneously. Multiscalar diagnostics also play a critical role in the area of computational code validation. In order to improve the design of combustion devices, computational codes for modeling turbulent combustion are often used to speed up and optimize the development process. The experimental validation of these codes is a critical step in accepting their predictions for engine performance in the absence of cost-prohibitive testing. One of the most critical aspects of setting up a time-resolved stimulated Raman scattering (SRS) diagnostic system is the temporal optical gating scheme. A short optical gate is necessary in order for weak SRS signals to be detected with a good signal- to-noise ratio (SNR) in the presence of strong background optical emissions. This time-synchronized optical gating is a classical problem even to other spectroscopic techniques such as laser-induced fluorescence (LIF) or laser-induced breakdown spectroscopy (LIBS). Traditionally, experimenters have had basically two options for gating: (1) an electronic means of gating using an image intensifier before the charge-coupled-device (CCD), or (2) a mechanical optical shutter (a rotary chopper/mechanical shutter combination). A new diagnostic technology has been developed at the NASA Glenn Research Center that utilizes a frame-transfer CCD sensor, in conjunction with a pulsed laser and multiplex optical fiber collection, to realize time-resolved Raman spectroscopy of turbulent flames that is free from optical background noise (interference). The technology permits not only shorter temporal optical gating (down

  16. Integrating nursing diagnostic concepts into the medical entities dictionary using the ISO Reference Terminology Model for Nursing Diagnosis.

    Science.gov (United States)

    Hwang, Jee-In; Cimino, James J; Bakken, Suzanne

    2003-01-01

    The purposes of the study were (1) to evaluate the usefulness of the International Standards Organization (ISO) Reference Terminology Model for Nursing Diagnoses as a terminology model for defining nursing diagnostic concepts in the Medical Entities Dictionary (MED) and (2) to create the additional hierarchical structures required for integration of nursing diagnostic concepts into the MED. The authors dissected nursing diagnostic terms from two source terminologies (Home Health Care Classification and the Omaha System) into the semantic categories of the ISO model. Consistent with the ISO model, they selected Focus and Judgment as required semantic categories for creating intensional definitions of nursing diagnostic concepts in the MED. Because the MED does not include Focus and Judgment hierarchies, the authors developed them to define the nursing diagnostic concepts. The ISO model was sufficient for dissecting the source terminologies into atomic terms. The authors identified 162 unique focus concepts from the 266 nursing diagnosis terms for inclusion in the Focus hierarchy. For the Judgment hierarchy, the authors precoordinated Judgment and Potentiality instead of using Potentiality as a qualifier of Judgment as in the ISO model. Impairment and Alteration were the most frequently occurring judgments. Nursing care represents a large proportion of health care activities; thus, it is vital that terms used by nurses are integrated into concept-oriented terminologies that provide broad coverage for the domain of health care. This study supports the utility of the ISO Reference Terminology Model for Nursing Diagnoses as a facilitator for the integration process.

  17. High precision instrumentation for measuring the true exposure time in diagnostic X-ray examinations

    International Nuclear Information System (INIS)

    Silva, Danubia B.; Santos, Marcus A.P.; Barros, Fabio R.; Santos, Luiz A.P.

    2013-01-01

    One of the most important physical quantities to be evaluated in diagnostic radiology is the radiation exposure time experimented by the patient during the X-ray examination. IAEA and WHO organizations have suggested that any country must create a quality surveillance program to verify if each type of ionizing radiation equipment used in the hospitals and medical clinics are in conformity with the accepted uncertainties following the international standards. The purpose of this work is to present a new high precision methodology for measuring true exposure time in diagnostic X-ray examinations: pulsed, continuous or digital one. An electronic system named CronoX, which will be soon registered at the Brazilian Patent Office (INPI), is the equipment that provides such a high precision measurement. The principle of measurement is based on the electrical signal captured by a sensor that enters in a regeneration amplifier to transform it in a digital signal, which is treated by a microprocessor (uP). The signal treatment results in a two measured times: 1) T rx , the true X-ray exposure time; 2) T nx , the time in which the X-ray machine is repeatedly cut off during the pulsed irradiation and there is no delivery dose to the patient. Conventional Polymat X-ray equipment and dental X-ray machines were used to generate X-ray photons and take the measurements with the electronic systems. The results show that such a high precision instrumentation displays the true exposure time in diagnostic X-ray examinations and indicates a new method to be purposed for the quality surveillance programs in radiology. (author)

  18. Quality and safety of integrated community case management of malaria using rapid diagnostic tests and pneumonia by community health workers.

    Science.gov (United States)

    Hamer, Davidson H; Brooks, Erin Twohig; Semrau, Katherine; Pilingana, Portipher; MacLeod, William B; Siazeele, Kazungu; Sabin, Lora L; Thea, Donald M; Yeboah-Antwi, Kojo

    2012-03-01

    To assess the quality and safety of having community health workers (CHWs) in rural Zambia use rapid diagnostic tests (RDTs) and provide integrated management of malaria and pneumonia. In the context of a cluster-randomized controlled trial of two models for community-based management of malaria and/or non-severe pneumonia in children under 5 years old, CHWs in the intervention arm were trained to use RDTs, follow a simple algorithm for classification and treat malaria with artemether-lumefantrine (AL) and pneumonia with amoxicillin. CHW records were reviewed to assess the ability of the CHWs to appropriately classify and treat malaria and pneumonia, and account for supplies. Patients were also followed up to assess treatment safety. During the 12-month study, the CHWs evaluated 1017 children with fever and/or fast/difficult breathing and performed 975 RDTs. Malaria and/or pneumonia were appropriately classified 94-100% of the time. Treatment based on disease classification was correct in 94-100% of episodes. Supply management was excellent with over 98% of RDTs, amoxicillin, and AL properly accounted for. The use of RDTs, amoxicillin, and AL was associated with few minor adverse events. Most febrile children (90%) with negative RDT results recovered after being treated with an antipyretic alone. Volunteer CHWs in rural Zambia are capable of providing integrated management of malaria and pneumonia to children safely and at high quality.

  19. Time-of-flight depth image enhancement using variable integration time

    Science.gov (United States)

    Kim, Sun Kwon; Choi, Ouk; Kang, Byongmin; Kim, James Dokyoon; Kim, Chang-Yeong

    2013-03-01

    Time-of-Flight (ToF) cameras are used for a variety of applications because it delivers depth information at a high frame rate. These cameras, however, suffer from challenging problems such as noise and motion artifacts. To increase signal-to-noise ratio (SNR), the camera should calculate a distance based on a large amount of infra-red light, which needs to be integrated over a long time. On the other hand, the integration time should be short enough to suppress motion artifacts. We propose a ToF depth imaging method to combine advantages of short and long integration times exploiting an imaging fusion scheme proposed for color imaging. To calibrate depth differences due to the change of integration times, a depth transfer function is estimated by analyzing the joint histogram of depths in the two images of different integration times. The depth images are then transformed into wavelet domains and fused into a depth image with suppressed noise and low motion artifacts. To evaluate the proposed method, we captured a moving bar of a metronome with different integration times. The experiment shows the proposed method could effectively remove the motion artifacts while preserving high SNR comparable to the depth images acquired during long integration time.

  20. Development of an Internal Real-Time Wireless Diagnostic Tool for a Proton Exchange Membrane Fuel Cell

    Directory of Open Access Journals (Sweden)

    Chi-Yuan Lee

    2018-01-01

    Full Text Available To prolong the operating time of unmanned aerial vehicles which use proton exchange membrane fuel cells (PEMFC, the performance of PEMFC is the key. However, a long-term operation can make the Pt particles of the catalyst layer and the pollutants in the feedstock gas bond together (e.g., CO, so that the catalyst loses reaction activity. The performance decay and aging of PEMFC will be influenced by operating conditions, temperature, flow and CO concentration. Therefore, this study proposes the development of an internal real-time wireless diagnostic tool for PEMFC, and uses micro-electro-mechanical systems (MEMS technology to develop a wireless and thin (<50 μm flexible integrated (temperature, flow and CO microsensor. The technical advantages are (1 compactness and three wireless measurement functions; (2 elastic measurement position and accurate embedding; (3 high accuracy and sensitivity and quick response; (4 real-time wireless monitoring of dynamic performance of PEMFC; (5 customized design and development. The flexible integrated microsensor is embedded in the PEMFC, three important physical quantities in the PEMFC, which are the temperature, flow and CO, can be measured simultaneously and instantly, so as to obtain the authentic and complete reaction in the PEMFC to enhance the performance of PEMFC and to prolong the service life.

  1. On-line diagnostic techniques for air-operated control valves based on time series analysis

    International Nuclear Information System (INIS)

    Ito, Kenji; Matsuoka, Yoshinori; Minamikawa, Shigeru; Komatsu, Yasuki; Satoh, Takeshi.

    1996-01-01

    The objective of this research is to study the feasibility of applying on-line diagnostic techniques based on time series analysis to air-operated control valves - numerous valves of the type which are used in PWR plants. Generally the techniques can detect anomalies by failures in the initial stages for which detection is difficult by conventional surveillance of process parameters measured directly. However, the effectiveness of these techniques depends on the system being diagnosed. The difficulties in applying diagnostic techniques to air-operated control valves seem to come from the reduced sensitivity of their response as compared with hydraulic control systems, as well as the need to identify anomalies in low level signals that fluctuate only slightly but continuously. In this research, simulation tests were performed by setting various kinds of failure modes for a test valve with the same specifications as of a valve actually used in the plants. Actual control signals recorded from an operating plant were then used as input signals for simulation. The results of the tests confirmed the feasibility of applying on-line diagnostic techniques based on time series analysis to air-operated control valves. (author)

  2. Timing and triggering of the Thomson scattering diagnostics on the COMPASS tokamak

    Czech Academy of Sciences Publication Activity Database

    Mikulín, Ondřej; Hron, Martin; Böhm, Petr; Naylor, G.; Bílková, Petra; Janky, Filip; Salášek, J.; Pánek, Radomír

    2014-01-01

    Roč. 89, č. 5 (2014), s. 693-697 ISSN 0920-3796. [The 9th Technical Meeting on Control, Data Acquisition, and Remote Participation for Fusion Research/9./. Hefei, 06.05.2013-10.05.2013] R&D Projects: GA MŠk 7G10072; GA MŠk(CZ) LM2011021; GA ČR GAP205/11/2470 Institutional support: RVO:61389021 Keywords : Tokamak * Timing and triggering * FPGA * Real-time control * Diagnostics control * Thomson scattering Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.152, year: 2014 http://www.sciencedirect.com/science/article/pii/S0920379614002105#

  3. Global Format for Conservative Time Integration in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Krenk, Steen

    2014-01-01

    The widely used classic collocation-based time integration procedures like Newmark, Generalized-alpha etc. generally work well within a framework of linear problems, but typically may encounter problems, when used in connection with essentially nonlinear structures. These problems are overcome....... In the present paper a conservative time integration algorithm is developed in a format using only the internal forces and the associated tangent stiffness at the specific time integration points. Thus, the procedure is computationally very similar to a collocation method, consisting of a series of nonlinear...... equivalent static load steps, easily implemented in existing computer codes. The paper considers two aspects: representation of nonlinear internal forces in a form that implies energy conservation, and the option of an algorithmic damping with the purpose of extracting energy from undesirable high...

  4. Study of time-critical diagnostic method for emergency operation of nuclear power plant

    International Nuclear Information System (INIS)

    Gofuku, A.; Yoshikawa, H.; Itoh, K.; Wakabayashi, J.

    1986-01-01

    In order to support the emergency operation of nuclear power plant, the method of time-critical diagnostic plant analyzer has been investigated. The conception of the emergency operation support center is proposed and two types of plant analyzer may be installed in this center. One analyzer is a real-time tracking simulation code using the observed signals and another is a fast trend-prediction code. A real-time tracking code, TOKRAC, has been developed for analyzing the PWR primary loop thermo-hydraulics at SBLOCA, and the applicability of this code was examined by the numerical experiments for the initial phase transient of both TMI-2 accident and 6% coldleg SBLOCA of a Westinghouse-type PWR plant. The results showed that fairly good tracking was carried out by TOKRAC. The CPU time of TOKRAC was about 12-14 percent of real-time

  5. Neutron time-of-flight ion temperature diagnostic for inertial confinement fusion experiments

    International Nuclear Information System (INIS)

    Chrien, R.E.; Simmons, D.F.; Holmberg, D.L.

    1992-01-01

    We are constructing a T i diagnostic for low neutron yield (5 x 10 7 to above 10 9 ) d-d and d-t targets in the Nova facility at Livermore. The diagnostic measures the neutron energy spread with 960 scintillator-photomultiplier detectors located 28 m from the target and operates in the single-hit mode. Each detector can measure a single neutron arrival with time resolution of 1 ns or better. The arrival time distribution is constructed from the results of typically 200--500 detector measurements. The ion temperature is determined from the spread in neutron energy ΔE n ∝ T i 1/2 , which is related to the arrival time spread by Δt/t = 1(1/2 ΔE n /E n ). Each neutron arrival is detected by using a photomultiplier tube to observe the recoil proton from elastic scattering in a fast plastic scintillator. The timing electronics for each channel consist of a novel constant fraction-like discriminator and a multiple hit time-to-digital converter (TDC). The overall system design, together with single channel performance data, is presented

  6. Explicit solution of Calderon preconditioned time domain integral equations

    KAUST Repository

    Ulku, Huseyin Arda

    2013-07-01

    An explicit marching on-in-time (MOT) scheme for solving Calderon-preconditioned time domain integral equations is proposed. The scheme uses Rao-Wilton-Glisson and Buffa-Christiansen functions to discretize the domain and range of the integral operators and a PE(CE)m type linear multistep to march on in time. Unlike its implicit counterpart, the proposed explicit solver requires the solution of an MOT system with a Gram matrix that is sparse and well-conditioned independent of the time step size. Numerical results demonstrate that the explicit solver maintains its accuracy and stability even when the time step size is chosen as large as that typically used by an implicit solver. © 2013 IEEE.

  7. A model of interval timing by neural integration.

    Science.gov (United States)

    Simen, Patrick; Balci, Fuat; de Souza, Laura; Cohen, Jonathan D; Holmes, Philip

    2011-06-22

    We show that simple assumptions about neural processing lead to a model of interval timing as a temporal integration process, in which a noisy firing-rate representation of time rises linearly on average toward a response threshold over the course of an interval. Our assumptions include: that neural spike trains are approximately independent Poisson processes, that correlations among them can be largely cancelled by balancing excitation and inhibition, that neural populations can act as integrators, and that the objective of timed behavior is maximal accuracy and minimal variance. The model accounts for a variety of physiological and behavioral findings in rodents, monkeys, and humans, including ramping firing rates between the onset of reward-predicting cues and the receipt of delayed rewards, and universally scale-invariant response time distributions in interval timing tasks. It furthermore makes specific, well-supported predictions about the skewness of these distributions, a feature of timing data that is usually ignored. The model also incorporates a rapid (potentially one-shot) duration-learning procedure. Human behavioral data support the learning rule's predictions regarding learning speed in sequences of timed responses. These results suggest that simple, integration-based models should play as prominent a role in interval timing theory as they do in theories of perceptual decision making, and that a common neural mechanism may underlie both types of behavior.

  8. Optimal Real-time Dispatch for Integrated Energy Systems

    DEFF Research Database (Denmark)

    Anvari-Moghaddam, Amjad; Guerrero, Josep M.; Rahimi-Kian, Ashkan

    2016-01-01

    With the emerging of small-scale integrated energy systems (IESs), there are significant potentials to increase the functionality of a typical demand-side management (DSM) strategy and typical implementation of building-level distributed energy resources (DERs). By integrating DSM and DERs...... into a cohesive, networked package that fully utilizes smart energy-efficient end-use devices, advanced building control/automation systems, and integrated communications architectures, it is possible to efficiently manage energy and comfort at the end-use location. In this paper, an ontology-driven multi......-agent control system with intelligent optimizers is proposed for optimal real-time dispatch of an integrated building and microgrid system considering coordinated demand response (DR) and DERs management. The optimal dispatch problem is formulated as a mixed integer nonlinear programing problem (MINLP...

  9. Effects of integration time on in-water radiometric profiles.

    Science.gov (United States)

    D'Alimonte, Davide; Zibordi, Giuseppe; Kajiyama, Tamito

    2018-03-05

    This work investigates the effects of integration time on in-water downward irradiance E d , upward irradiance E u and upwelling radiance L u profile data acquired with free-fall hyperspectral systems. Analyzed quantities are the subsurface value and the diffuse attenuation coefficient derived by applying linear and non-linear regression schemes. Case studies include oligotrophic waters (Case-1), as well as waters dominated by Colored Dissolved Organic Matter (CDOM) and Non-Algal Particles (NAP). Assuming a 24-bit digitization, measurements resulting from the accumulation of photons over integration times varying between 8 and 2048ms are evaluated at depths corresponding to: 1) the beginning of each integration interval (Fst); 2) the end of each integration interval (Lst); 3) the averages of Fst and Lst values (Avg); and finally 4) the values weighted accounting for the diffuse attenuation coefficient of water (Wgt). Statistical figures show that the effects of integration time can bias results well above 5% as a function of the depth definition. Results indicate the validity of the Wgt depth definition and the fair applicability of the Avg one. Instead, both the Fst and Lst depths should not be adopted since they may introduce pronounced biases in E u and L u regression products for highly absorbing waters. Finally, the study reconfirms the relevance of combining multiple radiometric casts into a single profile to increase precision of regression products.

  10. Tuberculosis Biomarker Extraction and Isothermal Amplification in an Integrated Diagnostic Device.

    Directory of Open Access Journals (Sweden)

    Amy Creecy

    Full Text Available In this study, we integrated magnetic bead-based sample preparation and isothermal loop mediated amplification (LAMP of TB in a single tube. Surrogate sputum samples produced by the Program for Appropriate Technology in Health containing inactivated TB bacteria were used to test the diagnostic. In order to test the sample preparation method, samples were lysed, and DNA was manually extracted and eluted into water in the tube. In a thermal cycler, LAMP amplified TB DNA from 103 TB cells/mL of sputum at 53.5 ± 3.3 minutes, 104 cells/mL at 46.3 ± 2.2 minutes, and 105 cells/mL at 41.6 ± 1.9 minutes. Negative control samples did not amplify. Next, sample preparation was combined with in-tubing isothermal LAMP amplification by replacing the water elution chamber with a LAMP reaction chamber. In this intermediate configuration, LAMP amplified 103 cells/mL at 74 ± 10 minutes, 104 cells/mL at 60 ± 9 minutes, and 105 TB cells/mL of sputum at 54 ± 9 minutes. Two of three negative controls did not amplify; one amplified at 100 minutes. In the semi-automated system, DNA was eluted directly into an isothermal reaction solution containing the faster OptiGene DNA polymerase. The low surrogate sputum concentration, 103 TB cells/mL, amplified at 52.8 ± 3.3 minutes, 104 cells/mL at 45.4 ± 11.3 minutes, and 105 cells/mL at 31.8 ± 2.9 minutes. TB negative samples amplified at 66.4 ± 7.4 minutes. This study demonstrated the feasibility of a single tube design for integrating sample preparation and isothermal amplification, which with further development could be useful for point-of-care applications, particularly in a low-resource setting.

  11. A New time Integration Scheme for Cahn-hilliard Equations

    KAUST Repository

    Schaefer, R.

    2015-06-01

    In this paper we present a new integration scheme that can be applied to solving difficult non-stationary non-linear problems. It is obtained by a successive linearization of the Crank- Nicolson scheme, that is unconditionally stable, but requires solving non-linear equation at each time step. We applied our linearized scheme for the time integration of the challenging Cahn-Hilliard equation, modeling the phase separation in fluids. At each time step the resulting variational equation is solved using higher-order isogeometric finite element method, with B- spline basis functions. The method was implemented in the PETIGA framework interfaced via the PETSc toolkit. The GMRES iterative solver was utilized for the solution of a resulting linear system at every time step. We also apply a simple adaptivity rule, which increases the time step size when the number of GMRES iterations is lower than 30. We compared our method with a non-linear, two stage predictor-multicorrector scheme, utilizing a sophisticated step length adaptivity. We controlled the stability of our simulations by monitoring the Ginzburg-Landau free energy functional. The proposed integration scheme outperforms the two-stage competitor in terms of the execution time, at the same time having a similar evolution of the free energy functional.

  12. A New time Integration Scheme for Cahn-hilliard Equations

    KAUST Repository

    Schaefer, R.; Smol-ka, M.; Dalcin, L; Paszyn'ski, M.

    2015-01-01

    In this paper we present a new integration scheme that can be applied to solving difficult non-stationary non-linear problems. It is obtained by a successive linearization of the Crank- Nicolson scheme, that is unconditionally stable, but requires solving non-linear equation at each time step. We applied our linearized scheme for the time integration of the challenging Cahn-Hilliard equation, modeling the phase separation in fluids. At each time step the resulting variational equation is solved using higher-order isogeometric finite element method, with B- spline basis functions. The method was implemented in the PETIGA framework interfaced via the PETSc toolkit. The GMRES iterative solver was utilized for the solution of a resulting linear system at every time step. We also apply a simple adaptivity rule, which increases the time step size when the number of GMRES iterations is lower than 30. We compared our method with a non-linear, two stage predictor-multicorrector scheme, utilizing a sophisticated step length adaptivity. We controlled the stability of our simulations by monitoring the Ginzburg-Landau free energy functional. The proposed integration scheme outperforms the two-stage competitor in terms of the execution time, at the same time having a similar evolution of the free energy functional.

  13. [Real time diagnostics of instantaneous temperature of combustion and explosion process by modern spectroscopy].

    Science.gov (United States)

    Zhou, Xue-tie; Wang, Jun-de; Li, Yan; Liu, Da-bing

    2003-04-01

    The combustion temperature is one of the important parameters to express flame combustion and explosion characteristics. It will effectively guide the design and manufacture of new model explosives, industrial explosive materials, and weapons. The recent developments and applications of real time diagnostics of instantaneous temperature of combustion and explosion processes by modern spectroscopic methods, such as atomic absorption-emission method, atomic emission two-line spectroscopy, atomic emission multiline spectroscopy, molecular rotation-vibration spectroscopy, coherent anti-stokes Raman scattering (CARS) and plane laser-induced fluorescence (PLIF), were reviewed in this paper. The maximum time resolution of atomic absorption-emission method is 25 microseconds. The time resolution of atomic emission two-line spectroscopy can reach 0.1 microsecond. These two methods can completely suit the need of real time and instantaneous temperature diagnostics of violent explosion and flame combustion. Other methods will also provide new effective research methods for the processes and characteristics of combustion, flame and explosion.

  14. Time resolved Thomson scattering diagnostic of pulsed gas metal arc welding (GMAW) process

    International Nuclear Information System (INIS)

    Kühn-Kauffeldt, M; Schein, J; Marquès, J L

    2014-01-01

    In this work a Thomson scattering diagnostic technique was applied to obtain time resolved electron temperature and density values during a gas metal arc welding (GMAW) process. The investigated GMAW process was run with aluminum wire (AlMg 4,5 Mn) with 1.2 mm diameter as a wire electrode, argon as a shielding gas and peak currents in the range of 400 A. Time resolved measurements could be achieved by triggering the laser pulse at shifted time positions with respect to the current pulse driving the process. Time evaluation of resulting electron temperatures and densities is used to investigate the state of the plasma in different phases of the current pulse and to determine the influence of the metal vapor and droplets on the plasma properties

  15. A higher order space-time Galerkin scheme for time domain integral equations

    KAUST Repository

    Pray, Andrew J.; Beghein, Yves; Nair, Naveen V.; Cools, Kristof; Bagci, Hakan; Shanker, Balasubramaniam

    2014-01-01

    Stability of time domain integral equation (TDIE) solvers has remained an elusive goal formany years. Advancement of this research has largely progressed on four fronts: 1) Exact integration, 2) Lubich quadrature, 3) smooth temporal basis functions, and 4) space-time separation of convolutions with the retarded potential. The latter method's efficacy in stabilizing solutions to the time domain electric field integral equation (TD-EFIE) was previously reported for first-order surface descriptions (flat elements) and zeroth-order functions as the temporal basis. In this work, we develop the methodology necessary to extend the scheme to higher order surface descriptions as well as to enable its use with higher order basis functions in both space and time. These basis functions are then used in a space-time Galerkin framework. A number of results are presented that demonstrate convergence in time. The viability of the space-time separation method in producing stable results is demonstrated experimentally for these examples.

  16. Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

    Science.gov (United States)

    Fassan, Matteo

    2018-03-01

    - Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

  17. Dental X-ray diagnostic facility with means to choose the time of exposure

    Energy Technology Data Exchange (ETDEWEB)

    Krause, H; Grassme, U

    1978-02-16

    Equipment for dental X-ray diagnostics with automatic exposure control. In the patient's mouth there is arranged a film carrier containing in a pocket a dental X-ray film. A detector-transmitter assembly touches the pocket. It reacts to the density of the film and wireless transmits a signal to an antenna. This antenna is connected to a receiver shutting off the high voltage of the X-ray tube by means of a circuit if a desired dose value is reached. The detector-transmitter unit is an integrated component. It has got a luminescent layer with a light-sensitive detector or a detector directly sensitive to X-rays.

  18. Orientation, Evaluation, and Integration of Part-Time Nursing Faculty.

    Science.gov (United States)

    Carlson, Joanne S

    2015-07-10

    This study helps to quantify and describe orientation, evaluation, and integration practices pertaining to part-time clinical nursing faculty teaching in prelicensure nursing education programs. A researcher designed Web-based survey was used to collect information from a convenience sample of part-time clinical nursing faculty teaching in prelicensure nursing programs. Survey questions focused on the amount and type of orientation, evaluation, and integration practices. Descriptive statistics were used to analyze results. Respondents reported on average four hours of orientation, with close to half reporting no more than two hours. Evaluative feedback was received much more often from students than from full-time faculty. Most respondents reported receiving some degree of mentoring and that it was easy to get help from full-time faculty. Respondents reported being most informed about student evaluation procedures, grading, and the steps to take when students are not meeting course objectives, and less informed about changes to ongoing curriculum and policy.

  19. Numerical counting ratemeter with variable time constant and integrated circuits

    International Nuclear Information System (INIS)

    Kaiser, J.; Fuan, J.

    1967-01-01

    We present here the prototype of a numerical counting ratemeter which is a special version of variable time-constant frequency meter (1). The originality of this work lies in the fact that the change in the time constant is carried out automatically. Since the criterion for this change is the accuracy in the annunciated result, the integration time is varied as a function of the frequency. For the prototype described in this report, the time constant varies from 1 sec to 1 millisec. for frequencies in the range 10 Hz to 10 MHz. This prototype is built entirely of MECL-type integrated circuits from Motorola and is thus contained in two relatively small boxes. (authors) [fr

  20. General new time formalism in the path integral

    International Nuclear Information System (INIS)

    Pak, N.K.; Sokmen, I.

    1983-08-01

    We describe a general method of applying point canonical transformations to the path integral followed by the corresponding new time transformations aimed at reducing an arbitrary one-dimensional problem into an exactly solvable form. Our result is independent of operator ordering ambiguities by construction. (author)

  1. Prospects for direct measurement of time-integrated Bs mixing

    International Nuclear Information System (INIS)

    Siccama, I.

    1994-01-01

    This note investigates the prospects of measuring time-integrated B s mixing. Three inclusive decay modes of the B s meson are discussed. For each reconstruction mode, the expected number of events and the different background channels are discussed. Estimates are given for the uncertainty on the mixing parameter χ s . (orig.)

  2. A Fully Integrated Discrete-Time Superheterodyne Receiver

    NARCIS (Netherlands)

    Tohidian, M.; Madadi, I.; Staszewski, R.B.

    2017-01-01

    The zero/low intermediate frequency (IF) receiver (RX) architecture has enabled full CMOS integration. As the technology scales and wireless standards become ever more challenging, the issues related to time-varying dc offsets, the second-order nonlinearity, and flicker noise become more critical.

  3. On the solution of high order stable time integration methods

    Czech Academy of Sciences Publication Activity Database

    Axelsson, Owe; Blaheta, Radim; Sysala, Stanislav; Ahmad, B.

    2013-01-01

    Roč. 108, č. 1 (2013), s. 1-22 ISSN 1687-2770 Institutional support: RVO:68145535 Keywords : evolution equations * preconditioners for quadratic matrix polynomials * a stiffly stable time integration method Subject RIV: BA - General Mathematics Impact factor: 0.836, year: 2013 http://www.boundaryvalueproblems.com/content/2013/1/108

  4. Integrated optical delay lines for time-division multiplexers

    NARCIS (Netherlands)

    Stopinski, S.T.; Malinowski, M.; Piramidowicz, R.; Kleijn, E.; Smit, M.K.; Leijtens, X.J.M.

    2013-01-01

    In this paper, we present a study of integrated optical delay lines (DLs) for application in optical time-division multiplexers. The investigated DLs are formed by spirally folded waveguides. The components were designed in a generic approach and fabricated in multi-project wafer runs on an

  5. Tomosynthesis in the Diagnostic Setting: Changing Rates of BI-RADS Final Assessment over Time.

    Science.gov (United States)

    Raghu, Madhavi; Durand, Melissa A; Andrejeva, Liva; Goehler, Alexander; Michalski, Mark H; Geisel, Jaime L; Hooley, Regina J; Horvath, Laura J; Butler, Reni; Forman, Howard P; Philpotts, Liane E

    2016-10-01

    Purpose To evaluate the effect of tomosynthesis in diagnostic mammography on the Breast Imaging Reporting and Data System (BI-RADS) final assessment categories over time. Materials and Methods This retrospective study was approved by the institutional review board. The authors reviewed all diagnostic mammograms obtained during a 12-month interval before (two-dimensional [2D] mammography [June 2, 2010, to June 1, 2011]) and for 3 consecutive years after (tomosynthesis year 1 [2012], tomosynthesis year 2 [2013], and tomosynthesis year 3 [2014]) the implementation of tomosynthesis. The requirement to obtain informed consent was waived. The rates of BI-RADS final assessment categories 1-5 were compared between the 2D and tomosynthesis groups. The positive predictive values after biopsy (PPV3) for BI-RADS category 4 and 5 cases were compared. The mammographic features (masses, architectural distortions, calcifications, focal asymmetries) of lesions categorized as probably benign (BI-RADS category 3) and those for which biopsy was recommended (BI-RADS category 4 or 5) were reviewed. The χ(2) test was used to compare the rates of BI-RADS final assessment categories 1-5 between the two groups, and multivariate logistic regression analysis was performed to compare all diagnostic studies categorized as BI-RADS 3-5. Results There was an increase in the percentage of cases reported as negative or benign (BI-RADS category 1 or 2) with tomosynthesis (58.7% with 2D mammography vs 75.8% with tomosynthesis at year 3, P tomosynthesis at year 3, P tomosynthesis (8.0% with 2D mammography vs 7.8% with tomosynthesis at year 3, P = .2), there was a significant increase in the PPV3 (29.6% vs 50%, respectively; P tomosynthesis use. Conclusion Tomosynthesis in the diagnostic setting resulted in progressive shifts in the BI-RADS final assessment categories over time, with a significant increase in the proportion of studies classified as normal, a continued decrease in the rate of studies

  6. Feasibility of real-time calculation of correlation integral derived statistics applied to EGG time series

    NARCIS (Netherlands)

    van den Broek, PLC; van Egmond, J; van Rijn, CM; Takens, F; Coenen, AML; Booij, LHDJ

    2005-01-01

    Background: This study assessed the feasibility of online calculation of the correlation integral (C(r)) aiming to apply C(r)derived statistics. For real-time application it is important to reduce calculation time. It is shown how our method works for EEG time series. Methods: To achieve online

  7. Feasibility of real-time calculation of correlation integral derived statistics applied to EEG time series

    NARCIS (Netherlands)

    Broek, P.L.C. van den; Egmond, J. van; Rijn, C.M. van; Takens, F.; Coenen, A.M.L.; Booij, L.H.D.J.

    2005-01-01

    This study assessed the feasibility of online calculation of the correlation integral (C(r)) aiming to apply C(r)-derived statistics. For real-time application it is important to reduce calculation time. It is shown how our method works for EEG time series. Methods: To achieve online calculation of

  8. A neutron time of flight spectrometer appropriate for D-T plasma diagnostics

    International Nuclear Information System (INIS)

    Elevant, T.

    1984-02-01

    A neutron time-of-flight spectrometer with 2 m flight path for diagnostics of deuterium plasmas in JET is presently under construction. An upgrade of this spectrometer to make it appropriate for 14-MeV neutron spectroscopy is presented here. It is suggested to use backscattering in a deuterium based scintillator. The flight path length is 1-2 m and the efficiency is of the order of 2.10 -5 cm -5 . Results from test of principle are presented with estimates for neutron and gamma backgrounds

  9. Building Modern Vibration Diagnostics Systems Based on the Frequency-Time Transformations of A Measured Signal

    Directory of Open Access Journals (Sweden)

    Yasoveev Vasikh

    2016-01-01

    Full Text Available Basic methods of analysis of vibration transducers signals were reviewed. Continuous wavelet transform, being a time-frequency transform, was found to be an advanced mathematical tool for analysis of vibration signals. Experimental studies revealed obvious changes in the continuous wavelet transform spectrum depending on the existing defects. A method for detection and identification of technological violations based on the analysis of CWT spectrum components and normalized correlation coefficient was suggested. In accordance with the suggested method software for vibration diagnostics was developed.

  10. Real-time diagnostics of fast light ion beams accelerated by a sub-nanosecond laser

    Czech Academy of Sciences Publication Activity Database

    Margarone, Daniele; Krása, Josef; Picciotto, A.; Prokůpek, Jan

    2011-01-01

    Roč. 56, č. 2 (2011), s. 137-141 ISSN 0029-5922 R&D Projects: GA ČR(CZ) GAP205/11/1165 EU Projects: European Commission(XE) 212105 - ELI-PP Institutional research plan: CEZ:AV0Z10100523 Keywords : laser-driven acceleration * ion beams * real-time diagnostics Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.389, year: 2011 http://www.nukleonika.pl/www/back/full/vol56_2011/v56n2p137f.pdf

  11. Multivariate analysis of diagnostic parameters derived from whole-kidney and parenchymal time-activity curves

    International Nuclear Information System (INIS)

    Bergmann, H.; Mostbeck, A.; Samal, M.; Nimmon, C.C.; Staudenherz, A.; Dudczak, R.

    2002-01-01

    Aim: In a previous work, we have confirmed earlier reports that time-activity curves of renal cortex provide additional useful diagnostic information. The aim of this experiment was to support the finding quantitatively using multiple regression. Materials and Methods: In a retrospective study, we have analyzed MAG3 renal data (90 kidneys in 57 children). Whole-kidney (WK) and parenchymal (PA) time-activity curves were extracted from 20 min pre-diuretic phase using standard WK and parenchymal fuzzy ROIs. Using multiple regression analysis, peak time, mean transit time, output efficiency, and four additional indices of residual activity in WK and PA ROIs were related to the maximum elimination rate (EM) of urine after the diuretic. The kidneys were divided into four groups according to the WK peak time (WKPT): WKPT longer than 0 (all kidneys), 5, 10, and 15 min. Results: Multiple correlation coefficients between the set of WK, PA, and WK+PA curve parameters (independent variables) and the log EM (dependent variable) for each group are summarized. Conclusions: Using pre-diuretic time-activity curves, it is possible to predict diuretic response. This can be useful when interpreting dubious results. Parenchymal curves predict diuretic response better than the whole-kidney curves. With increasing WKPT the whole-kidney curves become useless, while the parenchymal curves are still useful. Using both WK and PA curves produces the best results. This demonstrates that both WK and PA curves carry independent diagnostic information. The contribution obtained from the parenchymal curves certainly worth the difficulties and time required to draw additional ROIs. However, substantial efforts have to be given to the accurate and reproducible definition of parenchymal ROIs

  12. Front-end data reduction of diagnostic signals by real-time digital filtering

    International Nuclear Information System (INIS)

    Zasche, D.; Fahrbach, H.U.; Harmeyer, E.

    1985-01-01

    Diagnostic measurements on a fusion plasma with high resolution in space, time and signal amplitude involve handling large amounts of data. In the design of the soft-X-ray pinhole camera diagnostic for JET (100 detectors in 2 cameras) a new approach to this problem was found. The analogue-to-digital conversion is performed continuously at the highest sample rate of 200 kHz, lower sample rates (10 kHz, 1 kHz, 100 Hz) are obtained by real-time digital filters which calculate weighted averages over consecutive samples and are undersampled at their outputs to reduce the data rate. At any time, the signals from all detectors are available at all possible data rates in ring buffers. Thus the appropriate data rate can always be recorded on demand (preprogrammed or triggered by the experiment). With this system a reduction of the raw data by a factor of up to 2000 (typically 200) is possible without severe loss of information

  13. First Results from the South Pole Bang Time (SPBT) Diagnostic on the NIF*

    Science.gov (United States)

    Edgell, D. H.; Glebov, V. Yu.; Magoon, J.; Sangster, T. C.; Shoup, M. J., III; Stoeckl, C.; Macphee, A.; Bradley, D. K.; Burns, S.; Celeste, J.; Eckart, M. J.; Jones, O. S.; Kilkenny, J. D.; Kimbrough, J. R.; MacKinnon, A. J.; Parker, J.; Thomas, T.

    2011-10-01

    The south pole bang time (SPBT) x-ray diagnostic has been successfully fielded on the NIF. SPBT consists of chemical-vapor-deposition diamond detectors, with different filtrations, located 3 m directly below target chamber center, viewing the implosion through the hohlraum laser entrance hole. The diamond detectors are sensitive to both x rays and neutrons. HOPG crystal mirror monochromators increase the x-ray signal to background ratio. SPBT is designed to measure the x-ray bang time with an accuracy of a few tens of picoseconds. SPBT x-ray and neutron results from NIF implosions are presented along with timing and error analysis. *This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  14. Data and Analysis from a Time-Resolved Tomographic Optical Beam Diagnostic

    International Nuclear Information System (INIS)

    Frayer, Daniel K.; Johnson, Douglas; Ekdahl, Carl

    2010-01-01

    An optical tomographic diagnostic instrument developed for the acquisition of high-speed time-resolved images has been fielded at the Dual-Axis Radiographic Hydrodynamic Test (DARHT) Facility at Los Alamos National Laboratory. The instrument was developed for the creation of time histories of electron-beam cross section through the collection of Cerenkov light. Four optical lines of sight optically collapse an image and relay projections via an optical fiber relay to recording instruments; a tomographic reconstruction algorithm creates the time history. Because the instrument may be operated in an adverse environment, it may be operated, adjusted, and calibrated remotely. The instrument was operated over the course of various activities during and after DARHT commissioning, and tomographic reconstructions reported verifiable beam characteristics. Results from the collected data and reconstructions and analysis of the data are discussed.

  15. Multi-complexity ensemble measures for gait time series analysis: application to diagnostics, monitoring and biometrics.

    Science.gov (United States)

    Gavrishchaka, Valeriy; Senyukova, Olga; Davis, Kristina

    2015-01-01

    Previously, we have proposed to use complementary complexity measures discovered by boosting-like ensemble learning for the enhancement of quantitative indicators dealing with necessarily short physiological time series. We have confirmed robustness of such multi-complexity measures for heart rate variability analysis with the emphasis on detection of emerging and intermittent cardiac abnormalities. Recently, we presented preliminary results suggesting that such ensemble-based approach could be also effective in discovering universal meta-indicators for early detection and convenient monitoring of neurological abnormalities using gait time series. Here, we argue and demonstrate that these multi-complexity ensemble measures for gait time series analysis could have significantly wider application scope ranging from diagnostics and early detection of physiological regime change to gait-based biometrics applications.

  16. MERRA 2D IAU Diagnostic, Land Only States and Diagnostics, Time Average 1-hourly (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXLND or tavg1_2d_lnd_Nx data product is the MERRA Data Assimilation System 2-Dimensional land surface diagnostic that is time averaged single-level at the...

  17. Time Varying Market Integration and Expected Rteurns in Emerging Markets

    OpenAIRE

    Jong, F.C.J.M. de; Roon, F.A. de

    2001-01-01

    We use a simple model in which the expected returns in emerging markets depend on their systematic risk as measured by their beta relative to the world portfolio as well as on the level of integration in that market.The level of integration is a time-varying variable that depends on the market value of the assets that can be held by domestic investors only versus the market value of the assets that can be traded freely.Our empirical analysis for 30 emerging markets shows that there are strong...

  18. Energy conservation in Newmark based time integration algorithms

    DEFF Research Database (Denmark)

    Krenk, Steen

    2006-01-01

    Energy balance equations are established for the Newmark time integration algorithm, and for the derived algorithms with algorithmic damping introduced via averaging, the so-called a-methods. The energy balance equations form a sequence applicable to: Newmark integration of the undamped equations...... of motion, an extended form including structural damping, and finally the generalized form including structural as well as algorithmic damping. In all three cases the expression for energy, appearing in the balance equation, is the mechanical energy plus some additional terms generated by the discretization...

  19. Multisensory integration: the case of a time window of gesture-speech integration.

    Science.gov (United States)

    Obermeier, Christian; Gunter, Thomas C

    2015-02-01

    This experiment investigates the integration of gesture and speech from a multisensory perspective. In a disambiguation paradigm, participants were presented with short videos of an actress uttering sentences like "She was impressed by the BALL, because the GAME/DANCE...." The ambiguous noun (BALL) was accompanied by an iconic gesture fragment containing information to disambiguate the noun toward its dominant or subordinate meaning. We used four different temporal alignments between noun and gesture fragment: the identification point (IP) of the noun was either prior to (+120 msec), synchronous with (0 msec), or lagging behind the end of the gesture fragment (-200 and -600 msec). ERPs triggered to the IP of the noun showed significant differences for the integration of dominant and subordinate gesture fragments in the -200, 0, and +120 msec conditions. The outcome of this integration was revealed at the target words. These data suggest a time window for direct semantic gesture-speech integration ranging from at least -200 up to +120 msec. Although the -600 msec condition did not show any signs of direct integration at the homonym, significant disambiguation was found at the target word. An explorative analysis suggested that gesture information was directly integrated at the verb, indicating that there are multiple positions in a sentence where direct gesture-speech integration takes place. Ultimately, this would implicate that in natural communication, where a gesture lasts for some time, several aspects of that gesture will have their specific and possibly distinct impact on different positions in an utterance.

  20. ADHD and Present Hedonism: time perspective as a potential diagnostic and therapeutic tool.

    Science.gov (United States)

    Weissenberger, S; Klicperova-Baker, M; Zimbardo, P; Schonova, K; Akotia, D; Kostal, J; Goetz, M; Raboch, J; Ptacek, R

    2016-01-01

    The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations) and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD) symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo's time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201) are also presented. The hypothesis of relationship between ADHD and Present Hedonism is mainly derived from the prevalence of addictive behavior (mainly excessive Internet use, alcohol abuse, craving for sweets, fatty foods, and fast foods), deficits in social learning, and increased aggressiveness both in ADHD and in the population scoring high on Present Hedonism in the Zimbardo Time Perspective Inventory. We conclude that Zimbardo's time perspective offers both: 1) a potential diagnostic tool - the Zimbardo Time Perspective Inventory, particularly its Present Hedonism scale, and 2) a promising preventive and/or therapeutic approach by the Time Perspective Therapy. Time Perspective Therapy has so far been used mainly to treat past negative trauma (most notably, posttraumatic stress disorder); however, it also has value as a potential therapeutic tool for possible behavioral compensation of ADHD.

  1. Hybrid integrated circuit for charge-to-time interval conversion

    Energy Technology Data Exchange (ETDEWEB)

    Basiladze, S.G.; Dotsenko, Yu.Yu.; Man' yakov, P.K.; Fedorchenko, S.N. (Joint Inst. for Nuclear Research, Dubna (USSR))

    The hybrid integrated circuit for charge-to time interval conversion with nanosecond input fast response is described. The circuit can be used in energy measuring channels, time-to-digital converters and in the modified variant in amplitude-to-digital converters. The converter described consists of a buffer amplifier, a linear transmission circuit, a direct current source and a unit of time interval separation. The buffer amplifier represents a current follower providing low input and high output resistances by the current feedback. It is concluded that the described converter excelled the QT100B circuit analogous to it in a number of parameters especially, in thermostability.

  2. Integral-Value Models for Outcomes over Continuous Time

    DEFF Research Database (Denmark)

    Harvey, Charles M.; Østerdal, Lars Peter

    Models of preferences between outcomes over continuous time are important for individual, corporate, and social decision making, e.g., medical treatment, infrastructure development, and environmental regulation. This paper presents a foundation for such models. It shows that conditions on prefere...... on preferences between real- or vector-valued outcomes over continuous time are satisfied if and only if the preferences are represented by a value function having an integral form......Models of preferences between outcomes over continuous time are important for individual, corporate, and social decision making, e.g., medical treatment, infrastructure development, and environmental regulation. This paper presents a foundation for such models. It shows that conditions...

  3. A Digitally Programmable Differential Integrator with Enlarged Time Constant

    Directory of Open Access Journals (Sweden)

    S. K. Debroy

    1994-12-01

    Full Text Available A new Operational Amplifier (OA-RC integrator network is described. The novelties of the design are used of single grounded capacitor, ideal integration function realization with dual-input capability and design flexibility for extremely large time constant involving an enlargement factor (K using product of resistor ratios. The aspect of the digital control of K through a programmable resistor array (PRA controlled by a microprocessor has also been implemented. The effect of the OA-poles has been analyzed which indicates degradation of the integrator-Q at higher frequencies. An appropriate Q-compensation design scheme exhibiting 1 : |A|2 order of Q-improvement has been proposed with supporting experimental observations.

  4. Diagnostic value of performing endocervical curettage at the time of colposcopy procedure; a systematic review

    Directory of Open Access Journals (Sweden)

    Shabnam Imannezhad

    2016-03-01

    Full Text Available Introduction: The importance of high-grade cervical intraepithelial neoplasia (CIN as a precursor to invasive cervical cancer suggests a considerable need for accurate screening of the patients for the risk of these lesions. This systematic review aimed to study the diagnostic significance of endocervical curettage (ECC at the time of colposcopy in the detection of CIN 2, 3, and preinvasive lesions.Methods: PubMed was searched to obtain the relevant articles based on the following search term: (endocervical curettage OR ECC AND colposcopy. The most relevant articles were included after studying the title, abstract, and full text of the obtained articles at initial search. Only English language articles published after 1992 with at least 500 patients were included in this study.Result: Among 300 articles identified by the first search, only seven articles were in line with the purpose of this systematic review. Majority of the included studies were retrospective observational studies.Conclusion: Performing ECC has higher sensitivity in women older than 40 years and those with unsatisfactory colposcopy results. However exact diagnostic usefulness of ECC at the time of colposcopy needs to be investigated in further studies.

  5. RF Trip and Beam Loss Diagnostics in LEP using GPS timing

    CERN Document Server

    Arnaudon, L; Beetham, G; Ciapala, Edmond; Juillard, J C; Olsen, R; CERN. Geneva. SPS and LEP Division

    2000-01-01

    A fast diagnostics system has been installed in LEP to allow precise time-stamping of RF unit trips. The system also monitors the fast decay of current when a beam loss occurs. From the information gathered it is now possible to determine which RF units have provoked a beam loss at high energy and which have tripped as a result. The system uses GPS equipment installed at all of the even points of LEP together with fast local DSP acquisition and event recording units in each RF sector. An overall control application driven by the LEPExec arms the system at the start of each fill, calculates and displays RF and trip beam loss events in sequence, then stores the results in a database. The system installation was completed in time for the LEP 2000 startup and initial problems were quickly resolved. Throughout the year it has proved invaluable for high energy running. The experience gained will also be very useful for similar diagnostics applications in LHC.

  6. Integration and timing of basic and clinical sciences education.

    Science.gov (United States)

    Bandiera, Glen; Boucher, Andree; Neville, Alan; Kuper, Ayelet; Hodges, Brian

    2013-05-01

    Medical education has traditionally been compartmentalized into basic and clinical sciences, with the latter being viewed as the skillful application of the former. Over time, the relevance of basic sciences has become defined by their role in supporting clinical problem solving rather than being, of themselves, a defining knowledge base of physicians. As part of the national Future of Medical Education in Canada (FMEC MD) project, a comprehensive empirical environmental scan identified the timing and integration of basic sciences as a key pressing issue for medical education. Using the literature review, key informant interviews, stakeholder meetings, and subsequent consultation forums from the FMEC project, this paper details the empirical basis for focusing on the role of basic science, the evidentiary foundations for current practices, and the implications for medical education. Despite a dearth of definitive relevant studies, opinions about how best to integrate the sciences remain strong. Resource allocation, political power, educational philosophy, and the shift from a knowledge-based to a problem-solving profession all influence the debate. There was little disagreement that both sciences are important, that many traditional models emphasized deep understanding of limited basic science disciplines at the expense of other relevant content such as social sciences, or that teaching the sciences contemporaneously rather than sequentially has theoretical and practical merit. Innovations in integrated curriculum design have occurred internationally. Less clear are the appropriate balance of the sciences, the best integration model, and solutions to the political and practical challenges of integrated curricula. New curricula tend to emphasize integration, development of more diverse physician competencies, and preparation of physicians to adapt to evolving technology and patients' expectations. Refocusing the basic/clinical dichotomy to a foundational

  7. Integrated system fault diagnostics utilising digraph and fault tree-based approaches

    International Nuclear Information System (INIS)

    Bartlett, L.M.; Hurdle, E.E.; Kelly, E.M.

    2009-01-01

    With the growing intolerance to failures within systems, the issue of fault diagnosis has become ever prevalent. Information concerning these possible failures can help to minimise the disruption to the functionality of the system by allowing quick rectification. Traditional approaches to fault diagnosis within engineering systems have focused on sequential testing procedures and real-time mechanisms. Both methods have been predominantly limited to single fault causes. Latest approaches also consider the issue of multiple faults in reflection to the characteristics of modern day systems designed for high reliability. In addition, a diagnostic capability is required in real time and for changeable system functionality. This paper focuses on two approaches which have been developed to cater for the demands of diagnosis within current engineering systems, namely application of the fault tree analysis technique and the method of digraphs. Both use a comparative approach to consider differences between actual system behaviour and that expected. The procedural guidelines are discussed for each method, with an experimental aircraft fuel system used to test and demonstrate the features of the techniques. The effectiveness of the approaches is compared and their future potential highlighted

  8. Diagnostic stability of autism spectrum disorder in toddlers prospectively identified in a community-based setting: Behavioural characteristics and predictors of change over time.

    Science.gov (United States)

    Barbaro, Josephine; Dissanayake, Cheryl

    2017-10-01

    Autism spectrum disorder diagnoses in toddlers have been established as accurate and stable across time in high-risk siblings and clinic-referred samples. Few studies have investigated diagnostic stability in children prospective identified in community-based settings. Furthermore, there is a dearth of evidence on the individual behaviours that predict diagnostic change over time. The stability and change of autism spectrum disorder diagnoses were investigated from 24 to 48 months in 77 children drawn from the Social Attention and Communication Study. Diagnostic stability was high, with 88.3% overall stability and 85.5% autism spectrum disorder stability. The behavioural markers at 24 months that contributed to diagnostic shift off the autism spectrum by 48 months included better eye contact, more directed vocalisations, the integration of gaze and directed vocalisations/gestures and higher non-verbal developmental quotient. These four variables correctly predicted 88.7% of children into the autism spectrum disorder-stable and autism spectrum disorder-crossover groups overall, with excellent prediction for the stable group (96.2%) and modest prediction for the crossover group (44.4%). Furthermore, non-verbal developmental quotient at 24 months accounted for the significant improvement across time in 'Social Affect' scores on the Autism Diagnostic Observation Schedule for both groups and was the only unique predictor of diagnostic crossover. These findings contribute to the body of evidence on the feasibility of diagnoses at earlier ages to facilitate children's access to interventions to promote positive developmental outcomes.

  9. Automated high-throughput flow-through real-time diagnostic system

    Science.gov (United States)

    Regan, John Frederick

    2012-10-30

    An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.

  10. HMC algorithm with multiple time scale integration and mass preconditioning

    Science.gov (United States)

    Urbach, C.; Jansen, K.; Shindler, A.; Wenger, U.

    2006-01-01

    We present a variant of the HMC algorithm with mass preconditioning (Hasenbusch acceleration) and multiple time scale integration. We have tested this variant for standard Wilson fermions at β=5.6 and at pion masses ranging from 380 to 680 MeV. We show that in this situation its performance is comparable to the recently proposed HMC variant with domain decomposition as preconditioner. We give an update of the "Berlin Wall" figure, comparing the performance of our variant of the HMC algorithm to other published performance data. Advantages of the HMC algorithm with mass preconditioning and multiple time scale integration are that it is straightforward to implement and can be used in combination with a wide variety of lattice Dirac operators.

  11. Real-time hybrid simulation using the convolution integral method

    International Nuclear Information System (INIS)

    Kim, Sung Jig; Christenson, Richard E; Wojtkiewicz, Steven F; Johnson, Erik A

    2011-01-01

    This paper proposes a real-time hybrid simulation method that will allow complex systems to be tested within the hybrid test framework by employing the convolution integral (CI) method. The proposed CI method is potentially transformative for real-time hybrid simulation. The CI method can allow real-time hybrid simulation to be conducted regardless of the size and complexity of the numerical model and for numerical stability to be ensured in the presence of high frequency responses in the simulation. This paper presents the general theory behind the proposed CI method and provides experimental verification of the proposed method by comparing the CI method to the current integration time-stepping (ITS) method. Real-time hybrid simulation is conducted in the Advanced Hazard Mitigation Laboratory at the University of Connecticut. A seismically excited two-story shear frame building with a magneto-rheological (MR) fluid damper is selected as the test structure to experimentally validate the proposed method. The building structure is numerically modeled and simulated, while the MR damper is physically tested. Real-time hybrid simulation using the proposed CI method is shown to provide accurate results

  12. A high time resolution x-ray diagnostic on the Madison Symmetric Torus

    Science.gov (United States)

    DuBois, Ami M.; Lee, John David; Almagri, Abdulgadar F.

    2015-07-01

    A new high time resolution x-ray detector has been installed on the Madison Symmetric Torus (MST) to make measurements around sawtooth events. The detector system is comprised of a silicon avalanche photodiode, a 20 ns Gaussian shaping amplifier, and a 500 MHz digitizer with 14-bit sampling resolution. The fast shaping time diminishes the need to restrict the amount of x-ray flux reaching the detector, limiting the system dead-time. With a much higher time resolution than systems currently in use in high temperature plasma physics experiments, this new detector has the versatility to be used in a variety of discharges with varying flux and the ability to study dynamics on both slow and fast time scales. This paper discusses the new fast x-ray detector recently installed on MST and the improved time resolution capabilities compared to the existing soft and hard x-ray diagnostics. In addition to the detector hardware, improvements to the detector calibration and x-ray pulse identification software, such as additional fitting parameters and a more sophisticated fitting routine are discussed. Finally, initial data taken in both high confinement and standard reversed-field pinch plasma discharges are compared.

  13. Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.

    Science.gov (United States)

    Coccaro, Emil F

    2011-01-01

    This study was designed to develop a revised diagnostic criteria set for intermittent explosive disorder (IED) for consideration for inclusion in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). This revised criteria set was developed by integrating previous research criteria with elements from the current DSM-IV set of diagnostic criteria. Evidence supporting the reliability and validity of IED-IR ("IED Integrated Criteria") in a new and well-characterized group of subjects with personality disorder is presented. Clinical, phenomenologic, and diagnostic data from 201 individuals with personality disorder were reviewed. All IED diagnoses were assigned using a best-estimate process (eg, kappa for IED-IR >0.85). In addition, subjects meeting IED-IR criteria had higher scores on dimensional measures of aggression and had lower global functioning scores than non-IED-IR subjects, even when related variables were controlled. The IED-IR criteria were more sensitive than the DSM-IV criteria only in identifying subjects with significant impulsive-aggressive behavior by a factor of 16. We conclude that the IED-IR criteria can be reliably applied and have sufficient validity to warrant consideration as DSM-V criteria for IED. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. System Integration for Real-Time Mobile Manipulation

    Directory of Open Access Journals (Sweden)

    Reza Oftadeh

    2014-03-01

    Full Text Available Mobile manipulators are one of the most complicated types of mechatronics systems. The performance of these robots in performing complex manipulation tasks is highly correlated with the synchronization and integration of their low-level components. This paper discusses in detail the mechatronics design of a four wheel steered mobile manipulator. It presents the manipulator's mechanical structure and electrical interfaces, designs low-level software architecture based on embedded PC-based controls, and proposes a systematic solution based on code generation products of MATLAB and Simulink. The remote development environment described here is used to develop real-time controller software and modules for the mobile manipulator under a POSIX-compliant, real-time Linux operating system. Our approach enables developers to reliably design controller modules that meet the hard real-time constraints of the entire low-level system architecture. Moreover, it provides a systematic framework for the development and integration of hardware devices with various communication mediums and protocols, which facilitates the development and integration process of the software controller.

  15. Adaptive time-stepping Monte Carlo integration of Coulomb collisions

    Science.gov (United States)

    Särkimäki, K.; Hirvijoki, E.; Terävä, J.

    2018-01-01

    We report an accessible and robust tool for evaluating the effects of Coulomb collisions on a test particle in a plasma that obeys Maxwell-Jüttner statistics. The implementation is based on the Beliaev-Budker collision integral which allows both the test particle and the background plasma to be relativistic. The integration method supports adaptive time stepping, which is shown to greatly improve the computational efficiency. The Monte Carlo method is implemented for both the three-dimensional particle momentum space and the five-dimensional guiding center phase space. Detailed description is provided for both the physics and implementation of the operator. The focus is in adaptive integration of stochastic differential equations, which is an overlooked aspect among existing Monte Carlo implementations of Coulomb collision operators. We verify that our operator converges to known analytical results and demonstrate that careless implementation of the adaptive time step can lead to severely erroneous results. The operator is provided as a self-contained Fortran 95 module and can be included into existing orbit-following tools that trace either the full Larmor motion or the guiding center dynamics. The adaptive time-stepping algorithm is expected to be useful in situations where the collision frequencies vary greatly over the course of a simulation. Examples include the slowing-down of fusion products or other fast ions, and the Dreicer generation of runaway electrons as well as the generation of fast ions or electrons with ion or electron cyclotron resonance heating.

  16. Towards intelligent diagnostic system employing integration of mathematical and engineering model

    International Nuclear Information System (INIS)

    Isa, Nor Ashidi Mat

    2015-01-01

    The development of medical diagnostic system has been one of the main research fields during years. The goal of the medical diagnostic system is to place a nosological system that could ease the diagnostic evaluation normally performed by scientists and doctors. Efficient diagnostic evaluation is essentials and requires broad knowledge in order to improve conventional diagnostic system. Several approaches on developing the medical diagnostic system have been designed and tested since the earliest 60s. Attempts on improving their performance have been made which utilizes the fields of artificial intelligence, statistical analyses, mathematical model and engineering theories. With the availability of the microcomputer and software development as well as the promising aforementioned fields, medical diagnostic prototypes could be developed. In general, the medical diagnostic system consists of several stages, namely the 1) data acquisition, 2) feature extraction, 3) feature selection, and 4) classifications stages. Data acquisition stage plays an important role in converting the inputs measured from the real world physical conditions to the digital numeric values that can be manipulated by the computer system. One of the common medical inputs could be medical microscopic images, radiographic images, magnetic resonance image (MRI) as well as medical signals such as electrocardiogram (ECG) and electroencephalogram (EEG). Normally, the scientist or doctors have to deal with myriad of data and redundant to be processed. In order to reduce the complexity of the diagnosis process, only the significant features of the raw data such as peak value of the ECG signal or size of lesion in the mammogram images will be extracted and considered in the subsequent stages. Mathematical models and statistical analyses will be performed to select the most significant features to be classified. The statistical analyses such as principal component analysis and discriminant analysis as well

  17. Towards intelligent diagnostic system employing integration of mathematical and engineering model

    Science.gov (United States)

    Isa, Nor Ashidi Mat

    2015-05-01

    The development of medical diagnostic system has been one of the main research fields during years. The goal of the medical diagnostic system is to place a nosological system that could ease the diagnostic evaluation normally performed by scientists and doctors. Efficient diagnostic evaluation is essentials and requires broad knowledge in order to improve conventional diagnostic system. Several approaches on developing the medical diagnostic system have been designed and tested since the earliest 60s. Attempts on improving their performance have been made which utilizes the fields of artificial intelligence, statistical analyses, mathematical model and engineering theories. With the availability of the microcomputer and software development as well as the promising aforementioned fields, medical diagnostic prototypes could be developed. In general, the medical diagnostic system consists of several stages, namely the 1) data acquisition, 2) feature extraction, 3) feature selection, and 4) classifications stages. Data acquisition stage plays an important role in converting the inputs measured from the real world physical conditions to the digital numeric values that can be manipulated by the computer system. One of the common medical inputs could be medical microscopic images, radiographic images, magnetic resonance image (MRI) as well as medical signals such as electrocardiogram (ECG) and electroencephalogram (EEG). Normally, the scientist or doctors have to deal with myriad of data and redundant to be processed. In order to reduce the complexity of the diagnosis process, only the significant features of the raw data such as peak value of the ECG signal or size of lesion in the mammogram images will be extracted and considered in the subsequent stages. Mathematical models and statistical analyses will be performed to select the most significant features to be classified. The statistical analyses such as principal component analysis and discriminant analysis as well

  18. Towards intelligent diagnostic system employing integration of mathematical and engineering model

    Energy Technology Data Exchange (ETDEWEB)

    Isa, Nor Ashidi Mat [Imaging and Intelligent System Research Team (ISRT), School of Electrical and Electronic Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia)

    2015-05-15

    The development of medical diagnostic system has been one of the main research fields during years. The goal of the medical diagnostic system is to place a nosological system that could ease the diagnostic evaluation normally performed by scientists and doctors. Efficient diagnostic evaluation is essentials and requires broad knowledge in order to improve conventional diagnostic system. Several approaches on developing the medical diagnostic system have been designed and tested since the earliest 60s. Attempts on improving their performance have been made which utilizes the fields of artificial intelligence, statistical analyses, mathematical model and engineering theories. With the availability of the microcomputer and software development as well as the promising aforementioned fields, medical diagnostic prototypes could be developed. In general, the medical diagnostic system consists of several stages, namely the 1) data acquisition, 2) feature extraction, 3) feature selection, and 4) classifications stages. Data acquisition stage plays an important role in converting the inputs measured from the real world physical conditions to the digital numeric values that can be manipulated by the computer system. One of the common medical inputs could be medical microscopic images, radiographic images, magnetic resonance image (MRI) as well as medical signals such as electrocardiogram (ECG) and electroencephalogram (EEG). Normally, the scientist or doctors have to deal with myriad of data and redundant to be processed. In order to reduce the complexity of the diagnosis process, only the significant features of the raw data such as peak value of the ECG signal or size of lesion in the mammogram images will be extracted and considered in the subsequent stages. Mathematical models and statistical analyses will be performed to select the most significant features to be classified. The statistical analyses such as principal component analysis and discriminant analysis as well

  19. Evaluation of the filtered leapfrog-trapezoidal time integration method

    International Nuclear Information System (INIS)

    Roache, P.J.; Dietrich, D.E.

    1988-01-01

    An analysis and evaluation are presented for a new method of time integration for fluid dynamic proposed by Dietrich. The method, called the filtered leapfrog-trapezoidal (FLT) scheme, is analyzed for the one-dimensional constant-coefficient advection equation and is shown to have some advantages for quasi-steady flows. A modification (FLTW) using a weighted combination of FLT and leapfrog is developed which retains the advantages for steady flows, increases accuracy for time-dependent flows, and involves little coding effort. Merits and applicability are discussed

  20. Integration of Real-Time Data Into Building Automation Systems

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Stunder; Perry Sebastian; Brenda A. Chube; Michael D. Koontz

    2003-04-16

    The project goal was to investigate the possibility of using predictive real-time information from the Internet as an input to building management system algorithms. The objectives were to identify the types of information most valuable to commercial and residential building owners, managers, and system designers. To comprehensively investigate and document currently available electronic real-time information suitable for use in building management systems. Verify the reliability of the information and recommend accreditation methods for data and providers. Assess methodologies to automatically retrieve and utilize the information. Characterize equipment required to implement automated integration. Demonstrate the feasibility and benefits of using the information in building management systems. Identify evolutionary control strategies.

  1. Diagnostics for real-time plasma control in PBX-M

    Science.gov (United States)

    Kaita, R.; Batha, S.; Bell, R. E.; Bernabei, S.; Hatcher, R.; Kozub, T.; Kugel, H.; Levinton, F.; Okabayashi, M.; Sesnic, S.; von Goeler, S.; Zolfaghari, A.; PBX-M Group

    1995-01-01

    An important issue for future tokamaks is real-time plasma control for the avoidance of magnetohydrodynamic instabilities and other applications that require detailed plasma profile and fluctuation data. Although measurements from diagnostics providing this information require significantly more processing than magnetic flux data, recent advancements could make them practical for adjusting operational settings for plasma heating and current drive systems as well as field coil currents. On the Princeton Beta Experiment-Modification (PBX-M), the lower hybrid current drive phasing can be varied during a plasma shot using digitally programmable ferrite phase shifters, and neural beam functions can be fully computer controlled. PBX-M diagnostics that may be used for control purposes include motional Stark-effect polarimetry for magnetic field pitch angle profiles, soft x-ray arrays for plasma position control and the separation of βp from li, hard x-ray detectors for energetic electron distributions, a multichannel electron cyclotron emission radiometer for ballooning mode identification, and passive plate eddy current monitors for kink stabilization. We will describe the present status of these systems on PBX-M, and discuss their suitability for feedback applications.

  2. The diagnostic utility of sonographic carotid flow time in determining volume responsiveness.

    Science.gov (United States)

    Shokoohi, Hamid; Berry, Grant W; Shahkolahi, Murteza; King, Jackson; King, Jordan; Salimian, Mohammad; Poshtmashad, Ameneh; Pourmand, Ali

    2017-04-01

    We aimed to predict volume responsiveness and to assess the diagnostic accuracy of carotid flow time (FTc) with the change in hydration status before and after a passive leg raise (PLR) maneuver. Participants who presented at a community health fair in a dehydrated state following a prolonged fast while observing the month of Ramadan were recruited. Sonographic FTc measurements were obtained in the semi-Fowler position and after a PLR maneuver while participants were in a fasting state and repeated approximately 3 hours after breaking their fast. In total, 123 participants with mean age of 47±14 years, 55% male, were enrolled. Participants had fasted for an average of 16.9 hours and consumed an average of 933 mL between the 2 ultrasound measurements. Mean FTc values were significantly lower in the fasting state compared with the nonfasting state (312±22 vs 345±25milliseconds, P value change in FTc of ≥5% provides a reliable diagnostic accuracy for predicting fluid status. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Diagnostics for real-time plasma control in PBX-M

    International Nuclear Information System (INIS)

    Kaita, R.; Batha, S.; Bell, R.E.; Bernabei, S.; Hatcher, R.; Kozub, T.; Kugel, H.; Levinton, F.; Okabayashi, M.; Sesnic, S.; Goeler, S. von; Zolfaghari, A.

    1995-01-01

    An important issue for future tokamaks is real-time plasma control for the avoidance of magnetohydrodynamic instabilities and other applications that require detailed plasma profile and fluctuation data. Although measurements from diagnostics providing this information require significantly more processing than magnetic flux data, recent advancements could make them practical for adjusting operational settings for plasma heating and current drive systems as well as field coil currents. On the Princeton Beta Experiment-Modification (PBX-M), the lower hybrid current drive phasing can be varied during a plasma shot using digitally programmable ferrite phase shifters, and neural beam functions can be fully computer controlled. PBX-M diagnostics that may be used for control purposes include motional Stark-effect polarimetry for magnetic field pitch angle profiles, soft x-ray arrays for plasma position control and the separation of β p from l i , hard x-ray detectors for energetic electron distributions, a multichannel electron cyclotron emission radiometer for ballooning mode identification, and passive plate eddy current monitors for kink stabilization. We will describe the present status of these systems on PBX-M, and discuss their suitability for feedback applications

  4. On Tuning PI Controllers for Integrating Plus Time Delay Systems

    Directory of Open Access Journals (Sweden)

    David Di Ruscio

    2010-10-01

    Full Text Available Some analytical results concerning PI controller tuning based on integrator plus time delay models are worked out and presented. A method for obtaining PI controller parameters, Kp=alpha/(k*tau, and, Ti=beta*tau, which ensures a given prescribed maximum time delay error, dtau_max, to time delay, tau, ratio parameter delta=dau_max/tau, is presented. The corner stone in this method, is a method product parameter, c=alpha*beta. Analytical relations between the PI controller parameters, Ti, and, Kp, and the time delay error parameter, delta, is presented, and we propose the setting, beta=c/a*(delta+1, and, alpha=a/(delta+1, which gives, Ti=c/a*(delta+1*tau, and Kp=a/((delta+1*k*tau, where the parameter, a, is constant in the method product parameter, c=alpha*beta. It also turns out that the integral time, Ti, is linear in, delta, and the proportional gain, Kp, inversely proportional to, delta+1. For the original Ziegler Nichols (ZN method this parameter is approximately, c=2.38, and the presented method may e.g., be used to obtain new modified ZN parameters with increased robustness margins, also documented in the paper.

  5. Plaque reduction over time of an integrated oral hygiene system.

    Science.gov (United States)

    Nunn, Martha E; Ruhlman, C Douglas; Mallatt, Philip R; Rodriguez, Sally M; Ortblad, Katherine M

    2004-10-01

    This article compares the efficacy of a prototype integrated system (the IntelliClean System from Sonicare and Crest) in the reduction of supragingival plaque to that of a manual toothbrush and conventional toothpaste. The integrated system was compared to a manual toothbrush with conventional toothpaste in a randomized, single-blinded, parallel, 4-week, controlled clinical trial with 100 subjects randomized to each treatment group. There was a low dropout rate, with 89 subjects in the manual toothbrush group (11% loss to follow-up) and 93 subjects in the integrated system group (7% loss to follow-up) completing the study. The Turesky modification of the Quigley and Hein Plaque Index was used to assess full-mouth plaque scores for each subject. Prebrushing plaque scores were obtained at baseline and at 4 weeks after 14 to 20 hours of plaque accumulation. A survey also was conducted at the conclusion of the study to determine the attitude toward the two oral hygiene systems. The integrated system was found to significantly reduce overall and interproximal prebrushing plaque scores over 4 weeks, both by 8.6%, demonstrating statistically significant superiority in overall plaque reduction (P = .002) and interproximal plaque reduction (P < .001) compared to the manual toothbrush with conventional toothpaste, which showed no significant reduction in either overall plaque or interproximal plaque. This study demonstrates that the IntelliClean System from Sonicare and Crest is superior to a manual toothbrush with conventional toothpaste in reducing overall plaque and interproximal plaque over time.

  6. Rigorous time slicing approach to Feynman path integrals

    CERN Document Server

    Fujiwara, Daisuke

    2017-01-01

    This book proves that Feynman's original definition of the path integral actually converges to the fundamental solution of the Schrödinger equation at least in the short term if the potential is differentiable sufficiently many times and its derivatives of order equal to or higher than two are bounded. The semi-classical asymptotic formula up to the second term of the fundamental solution is also proved by a method different from that of Birkhoff. A bound of the remainder term is also proved. The Feynman path integral is a method of quantization using the Lagrangian function, whereas Schrödinger's quantization uses the Hamiltonian function. These two methods are believed to be equivalent. But equivalence is not fully proved mathematically, because, compared with Schrödinger's method, there is still much to be done concerning rigorous mathematical treatment of Feynman's method. Feynman himself defined a path integral as the limit of a sequence of integrals over finite-dimensional spaces which is obtained by...

  7. Real-time optical diagnostics of graphene growth induced by pulsed chemical vapor deposition

    Science.gov (United States)

    Puretzky, Alexander A.; Geohegan, David B.; Pannala, Sreekanth; Rouleau, Christopher M.; Regmi, Murari; Thonnard, Norbert; Eres, Gyula

    2013-06-01

    The kinetics and mechanisms of graphene growth on Ni films at 720-880 °C have been measured using fast pulses of acetylene and real-time optical diagnostics. In situ UV-Raman spectroscopy was used to unambiguously detect isothermal graphene growth at high temperatures, measure the growth kinetics with ~1 s temporal resolution, and estimate the fractional precipitation upon cooldown. Optical reflectivity and videography provided much faster temporal resolution. Both the growth kinetics and the fractional isothermal precipitation were found to be governed by the C2H2 partial pressure in the CVD pulse for a given film thickness and temperature, with up to ~94% of graphene growth occurring isothermally within 1 second at 800 °C at high partial pressures. At lower partial pressures, isothermal graphene growth is shown to continue 10 seconds after the gas pulse. These flux-dependent growth kinetics are described in the context of a dissolution/precipitation model, where carbon rapidly dissolves into the Ni film and later precipitates driven by gradients in the chemical potential. The combination of pulsed-CVD and real-time optical diagnostics opens new opportunities to understand and control the fast, sub-second growth of graphene on various substrates at high temperatures.The kinetics and mechanisms of graphene growth on Ni films at 720-880 °C have been measured using fast pulses of acetylene and real-time optical diagnostics. In situ UV-Raman spectroscopy was used to unambiguously detect isothermal graphene growth at high temperatures, measure the growth kinetics with ~1 s temporal resolution, and estimate the fractional precipitation upon cooldown. Optical reflectivity and videography provided much faster temporal resolution. Both the growth kinetics and the fractional isothermal precipitation were found to be governed by the C2H2 partial pressure in the CVD pulse for a given film thickness and temperature, with up to ~94% of graphene growth occurring isothermally

  8. ADHD and Present Hedonism: time perspective as a potential diagnostic and therapeutic tool

    Directory of Open Access Journals (Sweden)

    Weissenberger S

    2016-11-01

    Full Text Available S Weissenberger,1 M Klicperova-Baker,2 P Zimbardo,3 K Schonova,1 D Akotia,1 J Kostal,2 M Goetz,4 J Raboch,1 R Ptacek1 1First Medical Faculty, Charles University, 2Institute of Psychology, Academy of Sciences of the Czech Republic, Praha, Czech Republic; 3Department of Psychology, Stanford University, Stanford, CA, USA; 4Second Faculty of Medicine, Department of Child Psychiatry, Charles University, Motol University Hospital, Praha, Czech RepublicAbstract: The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo’s time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201 are also presented. The hypothesis of relationship between ADHD and Present Hedonism is mainly derived from the prevalence of addictive behavior (mainly excessive Internet use, alcohol abuse, craving for sweets, fatty foods, and fast foods, deficits in social learning, and increased aggressiveness both in ADHD and in the population high on Present Hedonism. We conclude that Zimbardo’s time perspective offers both: 1 a potential diagnostic tool – the Zimbardo Time Perspective Inventory, particularly its Present Hedonism scale, and 2 a promising preventive and/or therapeutic approach by the Time Perspective Therapy. Time Perspective Therapy has so far been used mainly to treat past negative trauma (most notably, posttraumatic stress disorder; however, it also has value as a potential therapeutic tool for possible behavioral compensation of ADHD.Keywords: ADHD, time perspective, ZTPI, Zimbardo, addiction, alcoholism, delinquency

  9. Integrated intensities in inverse time-of-flight technique

    International Nuclear Information System (INIS)

    Dorner, Bruno

    2006-01-01

    In traditional data analysis a model function, convoluted with the resolution, is fitted to the measured data. In case that integrated intensities of signals are of main interest, one can use an approach which does not require a model function for the signal nor detailed knowledge of the resolution. For inverse TOF technique, this approach consists of two steps: (i) Normalisation of the measured spectrum with the help of a monitor, with 1/k sensitivity, which is positioned in front of the sample. This means at the same time a conversion of the data from time of flight to energy transfer. (ii) A Jacobian [I. Waller, P.O. Froeman, Ark. Phys. 4 (1952) 183] transforms data collected at constant scattering angle into data as if measured at constant momentum transfer Q. This Jacobian works correctly for signals which have a constant width at different Q along the trajectory of constant scattering angle. The approach has been tested on spectra of Compton scattering with neutrons, having epithermal energies, obtained on the inverse TOF spectrometer VESUVIO/ISIS. In this case the width of the signal is increasing proportional to Q and in consequence the application of the Jacobian leads to integrated intensities slightly too high. The resulting integrated intensities agree very well with results derived in the traditional way. Thus this completely different approach confirms the observation that signals from recoil by H-atoms at large momentum transfers are weaker than expected

  10. Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

    Directory of Open Access Journals (Sweden)

    Calogero Cipolla

    2018-01-01

    Full Text Available Introduction. Sclerosing angiomatoid nodular transformation (SANT of the spleen is a rare benign vascular lesion with unknown etiopathogenesis and with definite features of imaging, histopathology, and immunohistochemistry. It was first described by Martel et al. in 2004, and to date, only 151 cases have been reported. Case Description. We report a case of SANT of the spleen detected in a 66-year-old Caucasian, without comorbidities, presented to our department with epigastric pain. We, also, presented a review of the literature. Conclusions. SANT is a benign incidentally vascular condition in the majority of cases. The wide age and gender distribution in our review is in accordance with that in previous studies in English literature. In our opinion, splenectomy is the choice treatment because it is at the same time diagnostic and therapeutic in a definitive way.

  11. Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time.

    Science.gov (United States)

    Cipolla, Calogero; Florena, Ada Maria; Ferrara, Gabriella; Di Gregorio, Riccardo; Unti, Elettra; Giannone, Antonino G; Lazzaro, Luigi A; Graceffa, Giuseppa; Pantuso, Gianni

    2018-01-01

    Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular lesion with unknown etiopathogenesis and with definite features of imaging, histopathology, and immunohistochemistry. It was first described by Martel et al. in 2004, and to date, only 151 cases have been reported. We report a case of SANT of the spleen detected in a 66-year-old Caucasian, without comorbidities, presented to our department with epigastric pain. We, also, presented a review of the literature. SANT is a benign incidentally vascular condition in the majority of cases. The wide age and gender distribution in our review is in accordance with that in previous studies in English literature. In our opinion, splenectomy is the choice treatment because it is at the same time diagnostic and therapeutic in a definitive way.

  12. Development of an Internal Real-Time Wireless Diagnostic Tool for a Proton Exchange Membrane Fuel Cell.

    Science.gov (United States)

    Lee, Chi-Yuan; Chen, Chia-Hung; Tsai, Chao-Hsuan; Wang, Yu-Syuan

    2018-01-13

    To prolong the operating time of unmanned aerial vehicles which use proton exchange membrane fuel cells (PEMFC), the performance of PEMFC is the key. However, a long-term operation can make the Pt particles of the catalyst layer and the pollutants in the feedstock gas bond together (e.g., CO), so that the catalyst loses reaction activity. The performance decay and aging of PEMFC will be influenced by operating conditions, temperature, flow and CO concentration. Therefore, this study proposes the development of an internal real-time wireless diagnostic tool for PEMFC, and uses micro-electro-mechanical systems (MEMS) technology to develop a wireless and thin (PEMFC; (5) customized design and development. The flexible integrated microsensor is embedded in the PEMFC, three important physical quantities in the PEMFC, which are the temperature, flow and CO, can be measured simultaneously and instantly, so as to obtain the authentic and complete reaction in the PEMFC to enhance the performance of PEMFC and to prolong the service life.

  13. Diagnostic Hearing Assessment in Schools: Validity and Time Efficiency of Automated Audiometry.

    Science.gov (United States)

    Mahomed-Asmail, Faheema; Swanepoel, De Wet; Eikelboom, Robert H

    2016-01-01

    Poor follow-up compliance from school-based hearing screening typically undermines the efficacy of school-based hearing screening programs. Onsite diagnostic audiometry with automation may reduce false positives and ensure directed referrals. To investigate the validity and time efficiency of automated diagnostic air- and bone-conduction audiometry for children in a natural school environment following hearing screening. A within-subject repeated measures design was employed to compare air- and bone-conduction pure-tone thresholds (0.5-4 kHz), measured by manual and automated pure-tone audiometry. Sixty-two children, 25 males and 37 females, with an average age of 8 yr (standard deviation [SD] = 0.92; range = 6-10 yr) were recruited for this study. The participants included 30 children who failed on a hearing screening and 32 children who passed a hearing screening. Threshold comparisons were made for air- and bone-conduction thresholds across ears tested with manual and automated audiometry. To avoid a floor effect thresholds of 15 dB HL were excluded in analyses. The Wilcoxon signed ranked test was used to compare threshold correspondence for manual and automated thresholds and the paired samples t-test was used to compare test time. Statistical significance was set as p ≤ 0.05. 85.7% of air-conduction thresholds and 44.6% of bone-conduction thresholds corresponded within the normal range (15 dB HL) for manual and automated audiometry. Both manual and automated audiometry air- and bone-conduction thresholds exceeded 15 dB HL in 9.9% and 34.0% of thresholds, respectively. For these thresholds, average absolute differences for air- and bone-conduction thresholds were 6.3 (SD = 8.3) and 2.2 dB (SD = 3.6) and they corresponded within 10 dB across frequencies in 87.7% and 100.0%, respectively. There was no significant difference between manual and automated air- and bone-conduction across frequencies for these thresholds. Using onsite automated diagnostic audiometry

  14. REMOTE DIAGNOSTICS OF TURNOUTS STATE ON TIMING AND SPECTRAL COMPOSITION IN CURRENT CURVE

    Directory of Open Access Journals (Sweden)

    S. Yu. Buryak

    2015-03-01

    Full Text Available Purpose. Development and implementation the points system diagnostics that would allow determining remotely the current state of turnout with all possible faults, gradual and sudden failures, damages, and in real time to report about their appearance. Methodology. State diagnostics on the values analysis of turnout main parameters is proposed to carry out with the help of a computer and analog-to-digital converter (ADC. Connecting measurements performance is advisable to produce to a shunt ammeter, installed in the working circuit of the point feed panel. ADC converts the analog signal of lost volts at the shunt into digital form and transmits it to a computer which stores the received data on its own recording medium for their further processing and storage. There is special software that is capable to reconnect signal and construct its temporal characteristic as well as decompose it on the spectral components. Using it one can analyze the obtained data, which allows diagnosing state of points upon change the nature, values and composition of the current curve. Findings. The computer diagnosis method was confirmed in practice for possible indications of problems that are associated with both the mechanical part of the turnout and the electrical part of it, while controlling parameters such as the amount of current normal transition, when working on frictions, the duration of the transition, properly adjusted headset and attachment points, the state of the motor. Originality. The use of computer technology in the diagnosis of the state of turnouts during their operation to monitor the current values of technical indicators, analysis and storage for all types of electric switches with different types of engines both DC and AC occurs through digitization and recording signal from measuring shunt of point feeder panel. Practical value. The proposed method enables timely, still in the early stages of defect parts, damages or failures of nodes

  15. Diagnostic Efficiency of MR Imaging of the Knee. Relationship to time Interval between MR and Arthroscopy

    International Nuclear Information System (INIS)

    Barrera, M. C.; Recondo, J. A.; Aperribay, M.; Gervas, C.; Fernandez, E.; Alustiza, J. M.

    2003-01-01

    To evaluate the efficiency of magnetic resonance (MR) in the diagnosis of knee lesions and how the results are influenced by the time interval between MR and arthroscopy. 248 knees studied by MR were retrospectively analyzed, as well as those which also underwent arthroscopy. Arthroscopy was considered to be the gold standard, MR diagnostic capacity was evaluated for both meniscal and cruciate ligament lesions. Sensitivity, specificity and Kappa index were calculated for the set of all knees included in the study (248), for those in which the time between MR and arthroscopy was less than or equal to three months (134) and for those in which the time between both procedures was less than or equal to one month. Sensitivity, specificity and Kappa index of the MR had global values of 96.5%, 70% and 71%, respectively. When the interval between MR and arthroscopy was less than or equal to three months, sensitivity, specificity and Kappa index were 95.5%, 75% and 72%, respectively. When it was less than or equal to one month, sensitivity was 100%, specificity was 87.5% and Kappa index was 91%. MR is an excellent tool for the diagnosis of knee lesions. Higher MR values of sensitivity, specificity and Kappa index are obtained when the time interval between both procedures is kept to a minimum. (Author) 11 refs

  16. Hybrid state-space time integration of rotating beams

    DEFF Research Database (Denmark)

    Krenk, Steen; Nielsen, Martin Bjerre

    2012-01-01

    An efficient time integration algorithm for the dynamic equations of flexible beams in a rotating frame of reference is presented. The equations of motion are formulated in a hybrid state-space format in terms of local displacements and local components of the absolute velocity. With inspiration...... of the system rotation enter via global operations with the angular velocity vector. The algorithm is based on an integrated form of the equations of motion with energy and momentum conserving properties, if a kinematically consistent non-linear formulation is used. A consistent monotonic scheme for algorithmic...... energy dissipation in terms of local displacements and velocities, typical of structural vibrations, is developed and implemented in the form of forward weighting of appropriate mean value terms in the algorithm. The algorithm is implemented for a beam theory with consistent quadratic non...

  17. Integrating speech in time depends on temporal expectancies and attention.

    Science.gov (United States)

    Scharinger, Mathias; Steinberg, Johanna; Tavano, Alessandro

    2017-08-01

    Sensory information that unfolds in time, such as in speech perception, relies on efficient chunking mechanisms in order to yield optimally-sized units for further processing. Whether or not two successive acoustic events receive a one-unit or a two-unit interpretation seems to depend on the fit between their temporal extent and a stipulated temporal window of integration. However, there is ongoing debate on how flexible this temporal window of integration should be, especially for the processing of speech sounds. Furthermore, there is no direct evidence of whether attention may modulate the temporal constraints on the integration window. For this reason, we here examine how different word durations, which lead to different temporal separations of sound onsets, interact with attention. In an Electroencephalography (EEG) study, participants actively and passively listened to words where word-final consonants were occasionally omitted. Words had either a natural duration or were artificially prolonged in order to increase the separation of speech sound onsets. Omission responses to incomplete speech input, originating in left temporal cortex, decreased when the critical speech sound was separated from previous sounds by more than 250 msec, i.e., when the separation was larger than the stipulated temporal window of integration (125-150 msec). Attention, on the other hand, only increased omission responses for stimuli with natural durations. We complemented the event-related potential (ERP) analyses by a frequency-domain analysis on the stimulus presentation rate. Notably, the power of stimulation frequency showed the same duration and attention effects than the omission responses. We interpret these findings on the background of existing research on temporal integration windows and further suggest that our findings may be accounted for within the framework of predictive coding. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Real time elastography - a non-invasive diagnostic method of small hepatocellular carcinoma in cirrhosis.

    Science.gov (United States)

    Gheorghe, Liana; Iacob, Speranta; Iacob, Razvan; Dumbrava, Mona; Becheanu, Gabriel; Herlea, Vlad; Gheorghe, Cristian; Lupescu, Ioana; Popescu, Irinel

    2009-12-01

    Small nodules (under 3 cm) detected on ultrasound (US) in cirrhotics represent the most challenging category for noninvasive diagnosis of hepatocellular carcinoma (HCC). To evaluate real-time sonoelastography as a noninvasive tool for the diagnosis of small HCC nodules in cirrhotic patients. 42 cirrhotic patients with 58 nodules (1-3 cm) were evaluated with real-time elastography (Hitachi EUB-6500); the mean intensity of colors red, blue, green were measured using a semi-quantitative method. Analysis of histograms for each color of the sonoelastography images was performed for quantifying the elasticity of nodule tissue in comparison with the cirrhotic liver tissue. AUROC curves were constructed to define the best cut-off points to distinguish malignant features of the nodules. Univariate and multivariate logistic regression analysis was performed. 595 sonoelastography images from 42 patients (25 men; 17 women) were analyzed. The mean age was 56.4 +/- 0.7 years and 69% patients were in Child-Pugh class A, 19% class B, 11% class C. For the mean intensity of green color AUROC=0.81, a cut-off value under 108.7 being diagnostic for HCC with a Sp=91.1%, Se=50%, PPV=92.1%, NPV=47.1%. Mean intensity of blue color proved to be an excellent diagnostic tool for HCC (AUROC=0.94); for a cut-off value greater than 128.9, Sp=92.2%, Se=78.9%, PPV=95.4%, NPV=68%. Independent predictive factors of HCC for a small nodule in cirrhotic patients were: blue color over 128.9 at sonoelastography and hypervascular appearance at Doppler US. US elastography is a promising method for the non-invasive diagnosis of early HCC. Blue color at elastography and hypervascular aspects are independent predictors of HCC.

  19. Design and relevant sample calculations for a neutral particle energy diagnostic based on time of flight

    Energy Technology Data Exchange (ETDEWEB)

    Cecconello, M

    1999-05-01

    Extrap T2 will be equipped with a neutral particles energy diagnostic based on time of flight technique. In this report, the expected neutral fluxes for Extrap T2 are estimated and discussed in order to determine the feasibility and the limits of such diagnostic. These estimates are based on a 1D model of the plasma. The input parameters of such model are the density and temperature radial profiles of electrons and ions and the density of neutrals at the edge and in the centre of the plasma. The atomic processes included in the model are the charge-exchange and the electron-impact ionization processes. The results indicate that the plasma attenuation length varies from a/5 to a, a being the minor radius. Differential neutral fluxes, as well as the estimated power losses due to CX processes (2 % of the input power), are in agreement with experimental results obtained in similar devices. The expected impurity influxes vary from 10{sup 14} to 10{sup 11} cm{sup -2}s{sup -1}. The neutral particles detection and acquisition systems are discussed. The maximum detectable energy varies from 1 to 3 keV depending on the flight distances d. The time resolution is 0.5 ms. Output signals from the waveform recorder are foreseen in the range 0-200 mV. An 8-bit waveform recorder having 2 MHz sampling frequency and 100K sample of memory capacity is the minimum requirement for the acquisition system 20 refs, 19 figs.

  20. Integral Time and the Varieties of Post-Mortem Survival

    Directory of Open Access Journals (Sweden)

    Sean M. Kelly

    2008-06-01

    Full Text Available While the question of survival of bodily death is usually approached by focusing on the mind/body relation (and often with the idea of the soul as a special kind of substance, this paper explores the issue in the context of our understanding of time. The argument of the paper is woven around the central intuition of time as an “ever-living present.” The development of this intuition allows for a more integral or “complex-holistic” theory of time, the soul, and the question of survival. Following the introductory matter, the first section proposes a re-interpretation of Nietzsche’s doctrine of eternal recurrence in terms of moments and lives as “eternally occurring.” The next section is a treatment of Julian Barbour’s neo-Machian model of instants of time as configurations in the n-dimensional phase-space he calls “Platonia.” While rejecting his claim to have done away with time, I do find his model suggestive of the idea of moments and lives as eternally occurring. The following section begins with Fechner’s visionary ideas of the nature of the soul and its survival of bodily death, with particular attention to the notion of holonic inclusion and the central analogy of the transition from perception to memory. I turn next to Whitehead’s equally holonic notions of prehension and the concrescence of actual occasions. From his epochal theory of time and certain ambiguities in his reflections on the “divine antinomies,” we are brought to the threshold of a potentially more integral or “complex-holistic” theory of time and survival, which is treated in the last section. This section draws from my earlier work on Hegel, Jung, and Edgar Morin, as well as from key insights of Jean Gebser, for an interpretation of Sri Aurobindo’s inspired but cryptic description of the “Supramental Time Vision.” This interpretation leads to an alternative understanding of reincarnation—and to the possibility of its reconciliation

  1. Integral Time and the Varieties of Post-Mortem Survival

    Directory of Open Access Journals (Sweden)

    Sean M. Kelly

    2008-06-01

    Full Text Available While the question of survival of bodily death is usually approached byfocusing on the mind/body relation (and often with the idea of the soul as a special kindof substance, this paper explores the issue in the context of our understanding of time.The argument of the paper is woven around the central intuition of time as an “everlivingpresent.” The development of this intuition allows for a more integral or “complexholistic”theory of time, the soul, and the question of survival. Following the introductorymatter, the first section proposes a re-interpretation of Nietzsche’s doctrine of eternalrecurrence in terms of moments and lives as “eternally occurring.” The next section is atreatment of Julian Barbour’s neo-Machian model of instants of time as configurations inthe n-dimensional phase-space he calls “Platonia.” While rejecting his claim to have doneaway with time, I do find his model suggestive of the idea of moments and lives aseternally occurring. The following section begins with Fechner’s visionary ideas of thenature of the soul and its survival of bodily death, with particular attention to the notionof holonic inclusion and the central analogy of the transition from perception to memory.I turn next to Whitehead’s equally holonic notions of prehension and the concrescence ofactual occasions. From his epochal theory of time and certain ambiguities in hisreflections on the “divine antinomies,” we are brought to the threshold of a potentiallymore integral or “complex-holistic” theory of time and survival, which is treated in thelast section. This section draws from my earlier work on Hegel, Jung, and Edgar Morin,as well as from key insights of Jean Gebser, for an interpretation of Sri Aurobindo’sinspired but cryptic description of the “Supramental Time Vision.” This interpretationleads to an alternative understanding of reincarnation—and to the possibility of itsreconciliation with the once-only view

  2. FLRW cosmology in Weyl-integrable space-time

    Energy Technology Data Exchange (ETDEWEB)

    Gannouji, Radouane [Department of Physics, Faculty of Science, Tokyo University of Science, 1–3, Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan); Nandan, Hemwati [Department of Physics, Gurukula Kangri Vishwavidayalaya, Haridwar 249404 (India); Dadhich, Naresh, E-mail: gannouji@rs.kagu.tus.ac.jp, E-mail: hntheory@yahoo.co.in, E-mail: nkd@iucaa.ernet.in [IUCAA, Post Bag 4, Ganeshkhind, Pune 411 007 (India)

    2011-11-01

    We investigate the Weyl space-time extension of general relativity (GR) for studying the FLRW cosmology through focusing and defocusing of the geodesic congruences. We have derived the equations of evolution for expansion, shear and rotation in the Weyl space-time. In particular, we consider the Starobinsky modification, f(R) = R+βR{sup 2}−2Λ, of gravity in the Einstein-Palatini formalism, which turns out to reduce to the Weyl integrable space-time (WIST) with the Weyl vector being a gradient. The modified Raychaudhuri equation takes the form of the Hill-type equation which is then analysed to study the formation of the caustics. In this model, it is possible to have a Big Bang singularity free cyclic Universe but unfortunately the periodicity turns out to be extremely short.

  3. Integrated project scheduling and staff assignment with controllable processing times.

    Science.gov (United States)

    Fernandez-Viagas, Victor; Framinan, Jose M

    2014-01-01

    This paper addresses a decision problem related to simultaneously scheduling the tasks in a project and assigning the staff to these tasks, taking into account that a task can be performed only by employees with certain skills, and that the length of each task depends on the number of employees assigned. This type of problems usually appears in service companies, where both tasks scheduling and staff assignment are closely related. An integer programming model for the problem is proposed, together with some extensions to cope with different situations. Additionally, the advantages of the controllable processing times approach are compared with the fixed processing times. Due to the complexity of the integrated model, a simple GRASP algorithm is implemented in order to obtain good, approximate solutions in short computation times.

  4. Integrated Project Scheduling and Staff Assignment with Controllable Processing Times

    Directory of Open Access Journals (Sweden)

    Victor Fernandez-Viagas

    2014-01-01

    Full Text Available This paper addresses a decision problem related to simultaneously scheduling the tasks in a project and assigning the staff to these tasks, taking into account that a task can be performed only by employees with certain skills, and that the length of each task depends on the number of employees assigned. This type of problems usually appears in service companies, where both tasks scheduling and staff assignment are closely related. An integer programming model for the problem is proposed, together with some extensions to cope with different situations. Additionally, the advantages of the controllable processing times approach are compared with the fixed processing times. Due to the complexity of the integrated model, a simple GRASP algorithm is implemented in order to obtain good, approximate solutions in short computation times.

  5. Keeping up with the times: revising the dermatology residency curriculum in the era of molecular diagnostics and personalized medicine.

    Science.gov (United States)

    LaChance, Avery; Murphy, Michael J

    2014-11-01

    The clinical use of molecular diagnostics, genomics, and personalized medicine is increasing and improving rapidly over time. However, medical education incorporating the practical application of these techniques is lagging behind. Although instruction in these areas should be expanded upon and improved at all levels of training, residency provides a concentrated period of time in which to hone in on skills that are practically applicable to a trainee's specialty of choice. Although residencies in some fields, such as pathology, have begun to incorporate practical molecular diagnostics training, this area remains a relative gap in dermatology residency programs. Herein, we advocate for the incorporation of training in molecular diagnostics and personalized medicine into dermatology residency programs and propose a basic curriculum template for how to begin approaching these topics. By incorporating molecular diagnostics into dermatology residency training, dermatologists have the opportunity to lead the way and actively shape the specialty's transition into the era of personalized medicine. © 2014 The International Society of Dermatology.

  6. Time step rescaling recovers continuous-time dynamical properties for discrete-time Langevin integration of nonequilibrium systems.

    Science.gov (United States)

    Sivak, David A; Chodera, John D; Crooks, Gavin E

    2014-06-19

    When simulating molecular systems using deterministic equations of motion (e.g., Newtonian dynamics), such equations are generally numerically integrated according to a well-developed set of algorithms that share commonly agreed-upon desirable properties. However, for stochastic equations of motion (e.g., Langevin dynamics), there is still broad disagreement over which integration algorithms are most appropriate. While multiple desiderata have been proposed throughout the literature, consensus on which criteria are important is absent, and no published integration scheme satisfies all desiderata simultaneously. Additional nontrivial complications stem from simulating systems driven out of equilibrium using existing stochastic integration schemes in conjunction with recently developed nonequilibrium fluctuation theorems. Here, we examine a family of discrete time integration schemes for Langevin dynamics, assessing how each member satisfies a variety of desiderata that have been enumerated in prior efforts to construct suitable Langevin integrators. We show that the incorporation of a novel time step rescaling in the deterministic updates of position and velocity can correct a number of dynamical defects in these integrators. Finally, we identify a particular splitting (related to the velocity Verlet discretization) that has essentially universally appropriate properties for the simulation of Langevin dynamics for molecular systems in equilibrium, nonequilibrium, and path sampling contexts.

  7. A higher order space-time Galerkin scheme for time domain integral equations

    KAUST Repository

    Pray, Andrew J.

    2014-12-01

    Stability of time domain integral equation (TDIE) solvers has remained an elusive goal formany years. Advancement of this research has largely progressed on four fronts: 1) Exact integration, 2) Lubich quadrature, 3) smooth temporal basis functions, and 4) space-time separation of convolutions with the retarded potential. The latter method\\'s efficacy in stabilizing solutions to the time domain electric field integral equation (TD-EFIE) was previously reported for first-order surface descriptions (flat elements) and zeroth-order functions as the temporal basis. In this work, we develop the methodology necessary to extend the scheme to higher order surface descriptions as well as to enable its use with higher order basis functions in both space and time. These basis functions are then used in a space-time Galerkin framework. A number of results are presented that demonstrate convergence in time. The viability of the space-time separation method in producing stable results is demonstrated experimentally for these examples.

  8. Technical Note: Reducing the spin-up time of integrated surface water–groundwater models

    KAUST Repository

    Ajami, H.

    2014-06-26

    One of the main challenges in catchment scale application of coupled/integrated hydrologic models is specifying a catchment\\'s initial conditions in terms of soil moisture and depth to water table (DTWT) distributions. One approach to reduce uncertainty in model initialization is to run the model recursively using a single or multiple years of forcing data until the system equilibrates with respect to state and diagnostic variables. However, such "spin-up" approaches often require many years of simulations, making them computationally intensive. In this study, a new hybrid approach was developed to reduce the computational burden of spin-up time for an integrated groundwater-surface water-land surface model (ParFlow.CLM) by using a combination of ParFlow.CLM simulations and an empirical DTWT function. The methodology is examined in two catchments located in the temperate and semi-arid regions of Denmark and Australia respectively. Our results illustrate that the hybrid approach reduced the spin-up time required by ParFlow.CLM by up to 50%, and we outline a methodology that is applicable to other coupled/integrated modelling frameworks when initialization from equilibrium state is required.

  9. Problematic game play: the diagnostic value of playing motives, passion, and playing time in men.

    Science.gov (United States)

    Kneer, Julia; Rieger, Diana

    2015-04-30

    Internet gaming disorder is currently listed in the DSM-not in order to diagnose such a disorder but to encourage research to investigate this phenomenon. Even whether it is still questionable if Internet Gaming Disorder exists and can be judged as a form of addiction, problematic game play is already very well researched to cause problems in daily life. Approaches trying to predict problematic tendencies in digital game play have mainly focused on playing time as a diagnostic criterion. However, motives to engage in digital game play and obsessive passion for game play have also been found to predict problematic game play but have not yet been investigated together. The present study aims at (1) analyzing if obsessive passion can be distinguished from problematic game play as separate concepts, and (2) testing motives of game play, passion, and playing time for their predictive values for problematic tendencies. We found (N = 99 males, Age: M = 22.80, SD = 3.81) that obsessive passion can be conceptually separated from problematic game play. In addition, the results suggest that compared to solely playing time immersion as playing motive and obsessive passion have added predictive value for problematic game play. The implications focus on broadening the criteria in order to diagnose problematic playing.

  10. Problematic Game Play: The Diagnostic Value of Playing Motives, Passion, and Playing Time in Men

    Directory of Open Access Journals (Sweden)

    Julia Kneer

    2015-04-01

    Full Text Available Internet gaming disorder is currently listed in the DSM—not in order to diagnose such a disorder but to encourage research to investigate this phenomenon. Even whether it is still questionable if Internet Gaming Disorder exists and can be judged as a form of addiction, problematic game play is already very well researched to cause problems in daily life. Approaches trying to predict problematic tendencies in digital game play have mainly focused on playing time as a diagnostic criterion. However, motives to engage in digital game play and obsessive passion for game play have also been found to predict problematic game play but have not yet been investigated together. The present study aims at (1 analyzing if obsessive passion can be distinguished from problematic game play as separate concepts, and (2 testing motives of game play, passion, and playing time for their predictive values for problematic tendencies. We found (N = 99 males, Age: M = 22.80, SD = 3.81 that obsessive passion can be conceptually separated from problematic game play. In addition, the results suggest that compared to solely playing time immersion as playing motive and obsessive passion have added predictive value for problematic game play. The implications focus on broadening the criteria in order to diagnose problematic playing.

  11. Noether symmetries and integrability in time-dependent Hamiltonian mechanics

    Directory of Open Access Journals (Sweden)

    Jovanović Božidar

    2016-01-01

    Full Text Available We consider Noether symmetries within Hamiltonian setting as transformations that preserve Poincaré-Cartan form, i.e., as symmetries of characteristic line bundles of nondegenerate 1-forms. In the case when the Poincaré-Cartan form is contact, the explicit expression for the symmetries in the inverse Noether theorem is given. As examples, we consider natural mechanical systems, in particular the Kepler problem. Finally, we prove a variant of the theorem on complete (non-commutative integrability in terms of Noether symmetries of time-dependent Hamiltonian systems.

  12. Optimizing the diagnostic power with gastric emptying scintigraphy at multiple time points

    Directory of Open Access Journals (Sweden)

    Gajewski Byron J

    2011-05-01

    Full Text Available Abstract Background Gastric Emptying Scintigraphy (GES at intervals over 4 hours after a standardized radio-labeled meal is commonly regarded as the gold standard for diagnosing gastroparesis. The objectives of this study were: 1 to investigate the best time point and the best combination of multiple time points for diagnosing gastroparesis with repeated GES measures, and 2 to contrast and cross-validate Fisher's Linear Discriminant Analysis (LDA, a rank based Distribution Free (DF approach, and the Classification And Regression Tree (CART model. Methods A total of 320 patients with GES measures at 1, 2, 3, and 4 hour (h after a standard meal using a standardized method were retrospectively collected. Area under the Receiver Operating Characteristic (ROC curve and the rate of false classification through jackknife cross-validation were used for model comparison. Results Due to strong correlation and an abnormality in data distribution, no substantial improvement in diagnostic power was found with the best linear combination by LDA approach even with data transformation. With DF method, the linear combination of 4-h and 3-h increased the Area Under the Curve (AUC and decreased the number of false classifications (0.87; 15.0% over individual time points (0.83, 0.82; 15.6%, 25.3%, for 4-h and 3-h, respectively at a higher sensitivity level (sensitivity = 0.9. The CART model using 4 hourly GES measurements along with patient's age was the most accurate diagnostic tool (AUC = 0.88, false classification = 13.8%. Patients having a 4-h gastric retention value >10% were 5 times more likely to have gastroparesis (179/207 = 86.5% than those with ≤10% (18/113 = 15.9%. Conclusions With a mixed group of patients either referred with suspected gastroparesis or investigated for other reasons, the CART model is more robust than the LDA and DF approaches, capable of accommodating covariate effects and can be generalized for cross institutional applications, but

  13. The Impact of Time-Series Diagnostic Tests on the Writing Ability of Iranian EFL learners

    Directory of Open Access Journals (Sweden)

    Bahareh Molazem Atashgahi

    2014-02-01

    Full Text Available This study aimed to show whether administering a battery of time-series diagnostic tests (screening has any impact on Iranian EFL learners’ writing ability. The study was conducted on the intermediate EFL learners at Islamic Azad University North Tehran branch.  The researcher administered a homogenizing test in order to exclude the exceptional scores, among all the testers, only those whose scores were nearly within one standard deviation above or below the mean were selected as the participants of this study. After the assignment of the participants to the control and experimental groups- 30 students in each group- they were asked to write five-paragraph-essays on two topics. Such a pretest was given to both groups to test their initial writing ability. Once scoring of the students’ writings (five- paragraph essay was finished the two means of the groups were calculated and compared with each other through the t-test analysis. The result demonstrated that there was no statistically significant difference between those two groups regarding the variable under investigation. Four sets of diagnostic tests were given to the experimental group every two weeks and after each test both the result of the exam and suitable feedback regarding students’ errors were given to them by the teacher, while the Current-Traditional Rhetoric method was administered in the control group. In the posttest which was run after giving the treatment and placebo to experimental group and control group respectively, students took another writing test with the same characteristics in administration, topics and scoring as the one in pretest. Thereafter, the significance of the difference between the obtained means of experimental and control groups in the posttest was determined through the t-test.  The result of the t-test analysis indicated a significant difference between the two groups which consequently rejected the null hypothesis of the study. Therefore, any

  14. Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time.

    Science.gov (United States)

    Serefoglu, E C; Cimen, H I; Ozdemir, A T; Symonds, T; Berktas, M; Balbay, M D

    2009-01-01

    There are uncertain issues on the diagnostic methods of premature ejaculation (PE). The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria in diagnosing PE and the aim of this study is to carry out the Turkish validation of the PEDT and to evaluate its association with intravaginal ejaculatory latency time (IELT). A total of 94 patients with a self-reported complaint of PE and 88 men without PE were enrolled into the study and requested to complete the nine-item PEDT, which was translated into Turkish. The patients were also requested to measure IELT. All participants were requested to come for a second visit to assess the PEDT's retest reliability; data from 78 men in the PE group and 69 men in the control group were collected. The IELT data of 35 patients were also recorded. The mean age of the PE group and the control group were 39.4+/-9.7 (24-65) and 30.1+/-5.7 (20-56), respectively, (P=0.068). Among the patients in the PE group, 24 (68.5%) reported life-long PE, whereas 11 (31.5%) reported acquired PE. The geometric mean IELT of the PE group was 59.7+/-46.2 (6.5-197.7) s. The number of men reporting IELTs of 2 min were 20 (57.1%), 11 (31.5) and 4 (11.4%), respectively. The factor analysis assessment showed that the five-item combination (questions 1, 2, 3, 4 and 8) explained 74.4% of the variance, there were no other combinations that explained the variance more effectively. Cronbach's alpha score of five-item combination was calculated as 0.77, showing adequate internal consistency. The overall Cronbach's alpha score did not increase if any item combination was deleted. The test-retest correlation coefficients of each item were higher than 0.80 and the correlation coefficient of the total score was 0.90. The PEDT and IELT showed an adequate correlation (rho=0.44). As a conclusion, the validated five-item Turkish version of PEDT is a

  15. ANALYSIS OF THE POSSIBILITY OF INTEGRATING A MINING RIGHT-ANGLE PLANETARY GEARBOX WITH TECHNICAL DIAGNOSTICS SYSTEMS

    Directory of Open Access Journals (Sweden)

    Andrzej WIECZOREK

    2016-12-01

    Full Text Available A key factor enabling the achievement of the required capacity by longwall mining systems is to obtain a satisfactory service life for individual components of such systems. Such components include right-angle planetary gearboxes for armoured face conveyors. An increase in the service life of such equipment can be achieved by ensuring adequacy in terms of design, materials and organization. As a part of organizational changes, the use of individual diagnostics systems may have the greatest impact on the service life of mining gearboxes; however, their widespread implementation is limited by economic and operational barriers. This paper presents an analysis of the possibility of integrating mining gearboxes with electronic systems of technical diagnostics, as well as expanding the scope of the technical condition monitoring by the machines operating together with these gearboxes. As a result of the calculation and design work performed, it has been demonstrated that it is possible to integrate technical diagnostics systems with advanced data transmission capabilities inside gearboxes.

  16. Integral ceramic superstructure evaluation using time domain optical coherence tomography

    Science.gov (United States)

    Sinescu, Cosmin; Bradu, Adrian; Topala, Florin I.; Negrutiu, Meda Lavinia; Duma, Virgil-Florin; Podoleanu, Adrian G.

    2014-02-01

    Optical Coherence Tomography (OCT) is a non-invasive low coherence interferometry technique that includes several technologies (and the corresponding devices and components), such as illumination and detection, interferometry, scanning, adaptive optics, microscopy and endoscopy. From its large area of applications, we consider in this paper a critical aspect in dentistry - to be investigated with a Time Domain (TD) OCT system. The clinical situation of an edentulous mandible is considered; it can be solved by inserting 2 to 6 implants. On these implants a mesostructure will be manufactured and on it a superstructure is needed. This superstructure can be integral ceramic; in this case materials defects could be trapped inside the ceramic layers and those defects could lead to fractures of the entire superstructure. In this paper we demonstrate that a TD-OCT imaging system has the potential to properly evaluate the presence of the defects inside the ceramic layers and those defects can be fixed before inserting the prosthesis inside the oral cavity. Three integral ceramic superstructures were developed by using a CAD/CAM technology. After the milling, the ceramic layers were applied on the core. All the three samples were evaluated by a TD-OCT system working at 1300 nm. For two of the superstructures evaluated, no defects were found in the most stressed areas. The third superstructure presented four ceramic defects in the mentioned areas. Because of those defects the superstructure may fracture. The integral ceramic prosthesis was send back to the dental laboratory to fix the problems related to the material defects found. Thus, TD-OCT proved to be a valuable method for diagnosing the ceramic defects inside the integral ceramic superstructures in order to prevent fractures at this level.

  17. A fuzzy logic intelligent diagnostic system for spacecraft integrated vehicle health management

    Science.gov (United States)

    Wu, G. Gordon

    1995-01-01

    Due to the complexity of future space missions and the large amount of data involved, greater autonomy in data processing is demanded for mission operations, training, and vehicle health management. In this paper, we develop a fuzzy logic intelligent diagnostic system to perform data reduction, data analysis, and fault diagnosis for spacecraft vehicle health management applications. The diagnostic system contains a data filter and an inference engine. The data filter is designed to intelligently select only the necessary data for analysis, while the inference engine is designed for failure detection, warning, and decision on corrective actions using fuzzy logic synthesis. Due to its adaptive nature and on-line learning ability, the diagnostic system is capable of dealing with environmental noise, uncertainties, conflict information, and sensor faults.

  18. Electric vehicle integration in a real-time market

    DEFF Research Database (Denmark)

    Pedersen, Anders Bro

    with an externally simulated model of the power grid, it is be possible, in real-time, to simulate the impact of EV charging and help to identify bottlenecks in the system. In EDISON the vehicles are aggregated using an entity called a Virtual Power Plant (VPP); a central server monitoring and controlling...... the distributed energy resources registered with it, in order to make them appear as a single producer in the eyes of the market. Although the concept of a VPP is used within the EcoGrid EU project, the idea of more individual control is introduced through a new proposed real-time electricity market, where......This project is rooted in the EDISON project, which dealt with Electrical Vehicle (EV) integration into the existing power grid, as well as with the infrastructure needed to facilitate the ever increasing penetration of fluctuating renewable energy resources like e.g. wind turbines. In the EDISON...

  19. Time-resolved x-ray line diagnostics of laser-produced plasmas

    International Nuclear Information System (INIS)

    Kauffman, R.L.; Matthews, D.L.; Kilkenny, J.D.; Lee, R.W.

    1982-11-01

    We have examined the underdense plasma conditions of laser irradiated disks using K x-rays from highly ionized ions. A 900 ps laser pulse of 0.532 μm light is used to irradiate various Z disks which have been doped with low concentrations of tracer materials. The tracers, whose Z's range from 13 to 22, are chosen so that their K x-ray spectrum is sensitive to typical underdense plasma temperatures and densities. Spectra are measured using a time-resolved crystal spectrograph recording the time history of the x-ray spectrum. A spatially-resolved, time-integrated crystal spectrograph also monitors the x-ray lines. Large differences in Al spectra are observed when the host plasms is changed from SiO 2 to PbO or In. Spectra will be presented along with preliminary analysis of the data

  20. Time-resolved x-ray line diagnostics of laser-produced plasmas

    International Nuclear Information System (INIS)

    Kauffman, R.L.; Matthews, D.L.; Kilkenny, J.D.; Lee, R.W.

    1982-01-01

    We have examined the underdense plasma conditions of laser irradiated disks using K x-rays from highly ionized ions. A 900 ps laser pulse of 0.532 μm light is used to irradiate various Z disks which have been doped with low concentrations of tracer materials. The tracers whose Z's range from 13 to 22 are chosen so that their K x-ray spectrum is sensitive to typical underdense plasma temperatures and densities. Spectra are measured using a time-resolved crystal spectrograph recording the time history of the x-ray spectrum. A spatially-resolved, time-integrated crystal spectrograph also monitors the x-ray lines. Large differences in Al spectra are observed when the host plasma is changed from SiO 2 to PbO or In. Spectra will be presented along with preliminary analysis of the data

  1. An integrated framework for SAGD real-time monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Mohajer, M.; Perez-Damas, C.; Berbin, A.; Al-kinani, A. [Schlumberger, Calgary, AB (Canada)

    2009-07-01

    This study examined the technologies and workflows for real-time optimization (RTO) of the steam assisted gravity drainage (SAGD) process. Although SAGD operators have tried to control the reservoir's steam chamber distribution to optimize bitumen recovery and minimize steam oil ratios, a true optimization can only be accomplished by implementing RTO workflows. In order for these workflows to be successful, some elements must be properly designed and introduced into the system. Most notably, well completions must ensure the integrity of downhole sensors; the appropriate measuring instruments must be selected; and surface and downhole measurements must be obtained. Operators have not been early adopters of RTO workflows for SAGD because of the numerous parameters that must be monitored, harsh operating conditions, the lack of integration between the different data acquisition systems, and the complex criteria required to optimize SAGD performance. This paper discussed the first stage in the development of a fully integrated RTO workflow for SAGD. An experimental apparatus with fiber optics distributed temperature sensing (DTS) was connected to a data acquisition system, and intra-minute data was streamed directly into an engineering desktop. The paper showed how subcool calculations can be effectively performed along the length of the horizontal well in real time and the results used to improve SAGD operation. Observations were compared against simulated predictions. In the next stage, a more complex set of criteria will be derived and additional data will be incorporated, such as surface heave, cross-well microseismic, multiphase flowmeter, and observation wells. 9 refs., 9 tabs., 13 figs.

  2. Integrative real-time geographic visualization of energy resources

    International Nuclear Information System (INIS)

    Sorokine, A.; Shankar, M.; Stovall, J.; Bhaduri, B.; King, T.; Fernandez, S.; Datar, N.; Omitaomu, O.

    2009-01-01

    'Full text:' Several models forecast that climatic changes will increase the frequency of disastrous events like droughts, hurricanes, and snow storms. Responding to these events and also to power outages caused by system errors such as the 2003 North American blackout require an interconnect-wide real-time monitoring system for various energy resources. Such a system should be capable of providing situational awareness to its users in the government and energy utilities by dynamically visualizing the status of the elements of the energy grid infrastructure and supply chain in geographic contexts. We demonstrate an approach that relies on Google Earth and similar standard-based platforms as client-side geographic viewers with a data-dependent server component. The users of the system can view status information in spatial and temporal contexts. These data can be integrated with a wide range of geographic sources including all standard Google Earth layers and a large number of energy and environmental data feeds. In addition, we show a real-time spatio-temporal data sharing capability across the users of the system, novel methods for visualizing dynamic network data, and a fine-grain access to very large multi-resolution geographic datasets for faster delivery of the data. The system can be extended to integrate contingency analysis results and other grid models to assess recovery and repair scenarios in the case of major disruption. (author)

  3. Earth System Models Underestimate Soil Carbon Diagnostic Times in Dry and Cold Regions.

    Science.gov (United States)

    Jing, W.; Xia, J.; Zhou, X.; Huang, K.; Huang, Y.; Jian, Z.; Jiang, L.; Xu, X.; Liang, J.; Wang, Y. P.; Luo, Y.

    2017-12-01

    Soils contain the largest organic carbon (C) reservoir in the Earth's surface and strongly modulate the terrestrial feedback to climate change. Large uncertainty exists in current Earth system models (ESMs) in simulating soil organic C (SOC) dynamics, calling for a systematic diagnosis on their performance based on observations. Here, we built a global database of SOC diagnostic time (i.e.,turnover times; τsoil) measured at 320 sites with four different approaches. We found that the estimated τsoil was comparable among approaches of 14C dating () (median with 25 and 75 percentiles), 13C shifts due to vegetation change () and the ratio of stock over flux (), but was shortest from laboratory incubation studies (). The state-of-the-art ESMs underestimated the τsoil in most biomes, even by >10 and >5 folds in cold and dry regions, respectively. Moreover,we identified clear negative dependences of τsoil on temperature and precipitation in both of the observational and modeling results. Compared with Community Land Model (version 4), the incorporation of soil vertical profile (CLM4.5) could substantially extend the τsoil of SOC. Our findings suggest the accuracy of climate-C cycle feedback in current ESMs could be enhanced by an improved understanding of SOC dynamics under the limited hydrothermal conditions.

  4. Schistosoma real-time PCR as diagnostic tool for international travellers and migrants.

    Science.gov (United States)

    Cnops, Lieselotte; Tannich, Egbert; Polman, Katja; Clerinx, Jan; Van Esbroeck, Marjan

    2012-10-01

    To evaluate the use of a genus-specific PCR that combines high sensitivity with the detection of different Schistosoma species for diagnosis in international travellers and migrants in comparison to standard microscopy. The genus-specific real-time PCR was developed to target the 28S ribosomal RNA gene of the major human Schistosoma species. It was validated for analytical specificity and reproducibility and demonstrated an analytical sensitivity of 0.2 eggs per gram of faeces. Its diagnostic performance was further evaluated on 152 faecal, 32 urine and 38 serum samples from patients presenting at the outpatient clinic of the Institute of Tropical Medicine in Antwerp (Belgium). We detected Schistosoma DNA in 76 faecal (50.0%) and five urine (15.6%) samples of which, respectively, nine and one were not detected by standard microscopy. Only two of the 38 serum samples of patients with confirmed schistosomiasis were positive with the presently developed PCR. Sequence analysis on positive faecal samples allowed identification of the Schistosoma species complex. The real-time PCR is highly sensitive and may offer added value in diagnosing imported schistosomiasis. The genus-specific PCR can detect all schistosome species that are infectious to humans and performs very well with faeces and urine, but not in serum. © 2012 Blackwell Publishing Ltd.

  5. Diagnostic accuracy of medical imagings and an integrated statistical approach to diagnosis. With special attention to hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Kawahira, Kosaburo

    1985-05-01

    Twenty-two patients with hepatocellular carcinoma and 36 without were clinically studied using angiography, computed tomography (CT), ultrasound (US) and Tc-99m phytate scintigraphy (RI). Diagnoses were confirmed by biopsy, surgery or autopsy, in all 58 patients. The judgement of multi-readers was obtained, independently. For a diagnosis of hepatocellular carcinoma, angiography was the most useful. Sensitivity, specificity and accuracy of this modality were 0.67, 0.85 and 0.78, respectively. Specificity and accuracy of US were 0.84 and 0.67, respectively, thereby US was the second best modality. CT was more useful than than RI for a diagnosis of hepatocellular carcinoma, in this series. Diagnostic accuracy of the 4 modalities in the diagnosis of liver mass were also discussed. To integrate these 4 images for a diagnosis of hepatocellular carcinoma, a multivariate analysis was made. The diagnostic accuracy of the system was considerably higher than that of any single modality.

  6. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers

    International Nuclear Information System (INIS)

    Upadhyaya, Belle R.; Hines, J. Wesley

    2004-01-01

    Integrity monitoring and flaw diagnostics of flat beams and tubular structures was investigated in this research task using guided acoustic signals. A piezo-sensor suite was deployed to activate and collect Lamb wave signals that propagate along metallic specimens. The dispersion curves of Lamb waves along plate and tubular structures are generated through numerical analysis. Several advanced techniques were explored to extract representative features from acoustic time series. Among them, the Hilbert-Huang transform (HHT) is a recently developed technique for the analysis of non-linear and transient signals. A moving window method was introduced to generate the local peak characters from acoustic time series, and a zooming window technique was developed to localize the structural flaws. The time-frequency analysis and pattern recognition techniques were combined for classifying structural defects in brass tubes. Several types of flaws in brass tubes were tested, both in the air and in water. The techniques also proved to be effective under background/process noise. A detailed theoretical analysis of Lamb wave propagation was performed and simulations were carried out using the finite element software system ABAQUS. This analytical study confirmed the behavior of the acoustic signals acquired from the experimental studies. The report presents the background the analysis of acoustic signals acquired from piezo-electric transducers for structural defect monitoring. A comparison of the use of time-frequency techniques, including the Hilbert-Huang transform, is presented. The report presents the theoretical study of Lamb wave propagation in flat beams and tubular structures, and the need for mode separation in order to effectively perform defect diagnosis. The results of an extensive experimental study of detection, location, and isolation of structural defects in flat aluminum beams and brass tubes are presented. The results of this research show the feasibility of on

  7. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Belle R. Upadhyaya; J. Wesley Hines

    2004-09-27

    Integrity monitoring and flaw diagnostics of flat beams and tubular structures was investigated in this research task using guided acoustic signals. A piezo-sensor suite was deployed to activate and collect Lamb wave signals that propagate along metallic specimens. The dispersion curves of Lamb waves along plate and tubular structures are generated through numerical analysis. Several advanced techniques were explored to extract representative features from acoustic time series. Among them, the Hilbert-Huang transform (HHT) is a recently developed technique for the analysis of non-linear and transient signals. A moving window method was introduced to generate the local peak characters from acoustic time series, and a zooming window technique was developed to localize the structural flaws. The time-frequency analysis and pattern recognition techniques were combined for classifying structural defects in brass tubes. Several types of flaws in brass tubes were tested, both in the air and in water. The techniques also proved to be effective under background/process noise. A detailed theoretical analysis of Lamb wave propagation was performed and simulations were carried out using the finite element software system ABAQUS. This analytical study confirmed the behavior of the acoustic signals acquired from the experimental studies. The report presents the background the analysis of acoustic signals acquired from piezo-electric transducers for structural defect monitoring. A comparison of the use of time-frequency techniques, including the Hilbert-Huang transform, is presented. The report presents the theoretical study of Lamb wave propagation in flat beams and tubular structures, and the need for mode separation in order to effectively perform defect diagnosis. The results of an extensive experimental study of detection, location, and isolation of structural defects in flat aluminum beams and brass tubes are presented. The results of this research show the feasibility of on

  8. Novel aspects in diagnostic approach to respiratory patients: is it the time for a new semiotics?

    Science.gov (United States)

    Soldati, Gino; Smargiassi, Andrea; Mariani, Alberto A; Inchingolo, Riccardo

    2017-01-01

    Medical approach to patients is a fundamental step to get the correct diagnosis. The aim of this paper is to analyze some aspects of the reasoning process inherent in medical diagnosis in our era. Pathologic signs (anamnestic data, symptoms, semiotics, laboratory and strumental findings) represent informative phenomena to be integrated for inferring a diagnosis. Thus, diagnosis begins with "signs" and finishes in a probability of disease. The abductive reasoning process is the generation of a hypothesis to explain one or more observations (signs) in order to decide between alternative explanations searching the best one. This process is iterative during the diagnostic activity while collecting further observations and it could be creative generating new knowledge about what has not been experienced before. In the clinical setting the abductive process is not only theoretical, conversely the physical exploitation of the patient (palpation, percussion, auscultation) is always crucial. Through this manipulative abduction, new and still unexpressed information is discovered and evaluated and physicians are able "to think through doing" to get the correct diagnosis. Abductive inferential path originates with an emotional reaction (discovery of the signs), step by step explanations are formed and it ends with another emotional reaction (diagnosis). Few bedside instruments are allowed to physicians to amplify their ability to search for signs. Stethoscope is an example. Similarities between ultrasound exploration and percussion can be found. Bedside ultrasonography can be considered an external amplifier of signs, a particular kind of percussion and represents a valid example of abductive manipulation. In this searching for signs doctors act like detectives and sometimes the discovering of a strategic, unsuspected sign during abductive manipulation could represent the key point for the correct diagnosis. This condition is called serendipity. Ultrasound is a powerful tool

  9. Integrating exhaled breath diagnostics by disease-sniffing dogs with instrumental laboratory analysis

    Science.gov (United States)

    Dogs have been studied for many years as a medical diagnostic tool to detect a pre-clinical disease state by sniffing emissions directly from a human or an in vitro biological sample. Some of the studies report high sensitivity and specificity in blinded case-control studies. How...

  10. An Integrated Architecture for On-Board Aircraft Engine Performance Trend Monitoring and Gas Path Fault Diagnostics

    Science.gov (United States)

    Simon, Donald L.

    2010-01-01

    Aircraft engine performance trend monitoring and gas path fault diagnostics are closely related technologies that assist operators in managing the health of their gas turbine engine assets. Trend monitoring is the process of monitoring the gradual performance change that an aircraft engine will naturally incur over time due to turbomachinery deterioration, while gas path diagnostics is the process of detecting and isolating the occurrence of any faults impacting engine flow-path performance. Today, performance trend monitoring and gas path fault diagnostic functions are performed by a combination of on-board and off-board strategies. On-board engine control computers contain logic that monitors for anomalous engine operation in real-time. Off-board ground stations are used to conduct fleet-wide engine trend monitoring and fault diagnostics based on data collected from each engine each flight. Continuing advances in avionics are enabling the migration of portions of the ground-based functionality on-board, giving rise to more sophisticated on-board engine health management capabilities. This paper reviews the conventional engine performance trend monitoring and gas path fault diagnostic architecture commonly applied today, and presents a proposed enhanced on-board architecture for future applications. The enhanced architecture gains real-time access to an expanded quantity of engine parameters, and provides advanced on-board model-based estimation capabilities. The benefits of the enhanced architecture include the real-time continuous monitoring of engine health, the early diagnosis of fault conditions, and the estimation of unmeasured engine performance parameters. A future vision to advance the enhanced architecture is also presented and discussed

  11. A real time zero-dimensional diagnostic model for the calculation of in-cylinder temperatures, HRR and nitrogen oxides in diesel engines

    International Nuclear Information System (INIS)

    Finesso, Roberto; Spessa, Ezio

    2014-01-01

    Highlights: • Real-time zero-dimensional three-zone diagnostic combustion model. • Capable of evaluating in-cylinder temperatures, HRR and NOx in DI diesel engines. • Able to be integrated in the engine ECU for control applications. • Able to be integrated in the test bed acquisition software for calibration tasks. • Tested under both steady state and fast transient conditions. - Abstract: A real-time zero-dimensional diagnostic combustion model has been developed and assessed to evaluate in-cylinder temperatures, HRR (heat release rate) and NOx (nitrogen oxides) in DI (Direct Injection) diesel engines under steady state and transient conditions. The approach requires very little computational time, that is, of the order of a few milliseconds, and is therefore suitable for real-time applications. It could, for example, be implemented in an ECU (Engine Control Unit) for the on-board diagnostics of combustion and emission formation processes, or it could be integrated in acquisition software installed on an engine test bench for indicated analysis. The model could also be used for post-processing analysis of previously acquired experimental data. The methodology is based on a three-zone thermodynamic model: the combustion chamber is divided into a fuel zone, an unburned gas zone and a stoichiometric burned gas zone, to which the energy and mass conservation equations are applied. The main novelty of the proposed method is that the equations can be solved in closed form, thus making the approach suitable for real-time applications. The evaluation of the temperature of burned gases allows the in-cylinder NOx concentration to be calculated, on the basis of prompt and Zeldovich thermal mechanisms. The procedure also takes into account the NOx level in the intake charge, and is therefore suitable for engines equipped with traditional short-route EGR (Exhaust Gas Recirculation) systems, and engines equipped with SCR (Selective Catalytic Reduction) and long

  12. Rapid tomographic reconstruction based on machine learning for time-resolved combustion diagnostics

    Science.gov (United States)

    Yu, Tao; Cai, Weiwei; Liu, Yingzheng

    2018-04-01

    Optical tomography has attracted surged research efforts recently due to the progress in both the imaging concepts and the sensor and laser technologies. The high spatial and temporal resolutions achievable by these methods provide unprecedented opportunity for diagnosis of complicated turbulent combustion. However, due to the high data throughput and the inefficiency of the prevailing iterative methods, the tomographic reconstructions which are typically conducted off-line are computationally formidable. In this work, we propose an efficient inversion method based on a machine learning algorithm, which can extract useful information from the previous reconstructions and build efficient neural networks to serve as a surrogate model to rapidly predict the reconstructions. Extreme learning machine is cited here as an example for demonstrative purpose simply due to its ease of implementation, fast learning speed, and good generalization performance. Extensive numerical studies were performed, and the results show that the new method can dramatically reduce the computational time compared with the classical iterative methods. This technique is expected to be an alternative to existing methods when sufficient training data are available. Although this work is discussed under the context of tomographic absorption spectroscopy, we expect it to be useful also to other high speed tomographic modalities such as volumetric laser-induced fluorescence and tomographic laser-induced incandescence which have been demonstrated for combustion diagnostics.

  13. Pneumatic oscillator circuits for timing and control of integrated microfluidics.

    Science.gov (United States)

    Duncan, Philip N; Nguyen, Transon V; Hui, Elliot E

    2013-11-05

    Frequency references are fundamental to most digital systems, providing the basis for process synchronization, timing of outputs, and waveform synthesis. Recently, there has been growing interest in digital logic systems that are constructed out of microfluidics rather than electronics, as a possible means toward fully integrated laboratory-on-a-chip systems that do not require any external control apparatus. However, the full realization of this goal has not been possible due to the lack of on-chip frequency references, thus requiring timing signals to be provided from off-chip. Although microfluidic oscillators have been demonstrated, there have been no reported efforts to characterize, model, or optimize timing accuracy, which is the fundamental metric of a clock. Here, we report pneumatic ring oscillator circuits built from microfluidic valves and channels. Further, we present a compressible-flow analysis that differs fundamentally from conventional circuit theory, and we show the utility of this physically based model for the optimization of oscillator stability. Finally, we leverage microfluidic clocks to demonstrate circuits for the generation of phase-shifted waveforms, self-driving peristaltic pumps, and frequency division. Thus, pneumatic oscillators can serve as on-chip frequency references for microfluidic digital logic circuits. On-chip clocks and pumps both constitute critical building blocks on the path toward achieving autonomous laboratory-on-a-chip devices.

  14. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers, Volumes 1, 2

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyaya, Belle R. [Univ. of Tennessee, Knoxville, TN (United States); Hines, J. Wesley [Univ. of Tennessee, Knoxville, TN (United States); Lu, Baofu [Univ. of Tennessee, Knoxville, TN (United States)

    2005-06-03

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001 September 2004. Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance.Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. Development of advanced signal processing methods using

  15. Integrating Real-time Earthquakes into Natural Hazard Courses

    Science.gov (United States)

    Furlong, K. P.; Benz, H. M.; Whitlock, J. S.; Bittenbinder, A. N.; Bogaert, B. B.

    2001-12-01

    Natural hazard courses are playing an increasingly important role in college and university earth science curricula. Students' intrinsic curiosity about the subject and the potential to make the course relevant to the interests of both science and non-science students make natural hazards courses popular additions to a department's offerings. However, one vital aspect of "real-life" natural hazard management that has not translated well into the classroom is the real-time nature of both events and response. The lack of a way to entrain students into the event/response mode has made implementing such real-time activities into classroom activities problematic. Although a variety of web sites provide near real-time postings of natural hazards, students essentially learn of the event after the fact. This is particularly true for earthquakes and other events with few precursors. As a result, the "time factor" and personal responsibility associated with natural hazard response is lost to the students. We have integrated the real-time aspects of earthquake response into two natural hazard courses at Penn State (a 'general education' course for non-science majors, and an upper-level course for science majors) by implementing a modification of the USGS Earthworm system. The Earthworm Database Management System (E-DBMS) catalogs current global seismic activity. It provides earthquake professionals with real-time email/cell phone alerts of global seismic activity and access to the data for review/revision purposes. We have modified this system so that real-time response can be used to address specific scientific, policy, and social questions in our classes. As a prototype of using the E-DBMS in courses, we have established an Earthworm server at Penn State. This server receives national and global seismic network data and, in turn, transmits the tailored alerts to "on-duty" students (e-mail, pager/cell phone notification). These students are responsible to react to the alarm

  16. A NASBA on microgel-tethered molecular-beacon microarray for real-time microbial molecular diagnostics.

    Science.gov (United States)

    Ma, Y; Dai, X; Hong, T; Munk, G B; Libera, M

    2016-12-19

    Despite their many advantages and successes, molecular beacon (MB) hybridization probes have not been extensively used in microarray formats because of the complicating probe-substrate interactions that increase the background intensity. We have previously shown that tethering to surface-patterned microgels is an effective means for localizing MB probes to specific surface locations in a microarray format while simultaneously maintaining them in as water-like an environment as possible and minimizing probe-surface interactions. Here we extend this approach to include both real-time detection together with integrated NASBA amplification. We fabricate small (∼250 μm × 250 μm) simplex, duplex, and five-plex assays with microarray spots of controllable size (∼20 μm diameter), position, and shape to detect bacteria and fungi in a bloodstream-infection model. The targets, primers, and microgel-tethered probes can be combined in a single isothermal reaction chamber with no post-amplification labelling. We extract total RNA from clinical blood samples and differentiate between Gram-positive and Gram-negative bloodstream infection in a duplex assay to detect RNA- amplicons. The sensitivity based on our current protocols in a simplex assay to detect specific ribosomal RNA sequences within total RNA extracted from S. aureus and E. coli cultures corresponds to tens of bacteria per ml. We furthermore show that the platform can detect RNA- amplicons from synthetic target DNA with 1 fM sensitivity in sample volumes that contain about 12 000 DNA molecules. These experiments demonstrate an alternative approach that can enable rapid and real-time microarray-based molecular diagnostics.

  17. Real-Time Adaptive Algorithms for Flight Control Diagnostics and Prognostics, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Model-based machinery diagnostic and prognostic techniques depend upon high-quality mathematical models of the plant. Modeling uncertainties and errors decrease...

  18. Human transmissible spongiform encephalopathies in eleven countries: Diagnostic pattern across time, 1993-2002

    NARCIS (Netherlands)

    J. de Pedro-Cuesta (Jesús); M. Glatzel (Markus); J. Almazán (Javier); K. Stoeck (Katharina); V. Mellina (Vittorio); M. Puopolo (Maria); M. Pocchiari (Maurizio); I. Zerr (Inga); H.A. Kretszchmar (Hans); J-P. Brandel (Jean-Philippe); N. Delasnerie-Laupretre (Nicole); A. Alperovitch (Annick); C.M. van Duijn (Cornelia); P. Sanchez-Juan (Pascual); S.J. Collins (Steven); V. Lewis (Victoria); G.H. Jansen (Gerard); M.B. Coulthart (Michael); E. Gelpi (Ellen); H. Budka (Herbert); E. Mitrová (Eva)

    2006-01-01

    textabstractBackground: The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. Methods: From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible

  19. A magnetic particle time-of-flight (MagPTOF) diagnostic for measurements of shock- and compression-bang time at the NIF (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Rinderknecht, H. G., E-mail: hgr@mit.edu; Sio, H.; Frenje, J. A.; Gatu Johnson, M.; Zylstra, A. B.; Sinenian, N.; Rosenberg, M. J.; Li, C. K.; Sèguin, F. H.; Petrasso, R. D. [Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Magoon, J.; Agliata, A.; Shoup, M.; Glebov, V. U.; Hohenberger, M.; Stoeckl, C.; Sangster, T. C. [Laboratory for Laser Energetics, Rochester, New York 14623 (United States); Ayers, S.; Bailey, C. G.; Rygg, J. R. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); and others

    2014-11-15

    A magnetic particle time-of-flight (MagPTOF) diagnostic has been designed to measure shock- and compression-bang time using D{sup 3}He-fusion protons and DD-fusion neutrons, respectively, at the National Ignition Facility (NIF). This capability, in combination with shock-burn weighted areal density measurements, will significantly constrain the modeling of the implosion dynamics. This design is an upgrade to the existing particle time-of-flight (pTOF) diagnostic, which records bang times using DD or DT neutrons with an accuracy better than ±70 ps [H. G. Rinderknecht et al., Rev. Sci. Instrum. 83, 10D902 (2012)]. The inclusion of a deflecting magnet will increase D{sup 3}He-proton signal-to-background by a factor of 1000, allowing for the first time simultaneous measurements of shock- and compression-bang times in D{sup 3}He-filled surrogate implosions at the NIF.

  20. A magnetic particle time-of-flight (MagPTOF) diagnostic for measurements of shock- and compression-bang time at the NIF (invited).

    Science.gov (United States)

    Rinderknecht, H G; Sio, H; Frenje, J A; Magoon, J; Agliata, A; Shoup, M; Ayers, S; Bailey, C G; Gatu Johnson, M; Zylstra, A B; Sinenian, N; Rosenberg, M J; Li, C K; Sèguin, F H; Petrasso, R D; Rygg, J R; Kimbrough, J R; Mackinnon, A; Bell, P; Bionta, R; Clancy, T; Zacharias, R; House, A; Döppner, T; Park, H S; LePape, S; Landen, O; Meezan, N; Robey, H; Glebov, V U; Hohenberger, M; Stoeckl, C; Sangster, T C; Li, C; Parat, J; Olson, R; Kline, J; Kilkenny, J

    2014-11-01

    A magnetic particle time-of-flight (MagPTOF) diagnostic has been designed to measure shock- and compression-bang time using D(3)He-fusion protons and DD-fusion neutrons, respectively, at the National Ignition Facility (NIF). This capability, in combination with shock-burn weighted areal density measurements, will significantly constrain the modeling of the implosion dynamics. This design is an upgrade to the existing particle time-of-flight (pTOF) diagnostic, which records bang times using DD or DT neutrons with an accuracy better than ±70 ps [H. G. Rinderknecht et al., Rev. Sci. Instrum. 83, 10D902 (2012)]. The inclusion of a deflecting magnet will increase D(3)He-proton signal-to-background by a factor of 1000, allowing for the first time simultaneous measurements of shock- and compression-bang times in D(3)He-filled surrogate implosions at the NIF.

  1. Parareal algorithms with local time-integrators for time fractional differential equations

    Science.gov (United States)

    Wu, Shu-Lin; Zhou, Tao

    2018-04-01

    It is challenge work to design parareal algorithms for time-fractional differential equations due to the historical effect of the fractional operator. A direct extension of the classical parareal method to such equations will lead to unbalance computational time in each process. In this work, we present an efficient parareal iteration scheme to overcome this issue, by adopting two recently developed local time-integrators for time fractional operators. In both approaches, one introduces auxiliary variables to localized the fractional operator. To this end, we propose a new strategy to perform the coarse grid correction so that the auxiliary variables and the solution variable are corrected separately in a mixed pattern. It is shown that the proposed parareal algorithm admits robust rate of convergence. Numerical examples are presented to support our conclusions.

  2. Integration time for the perception of depth from motion parallax.

    Science.gov (United States)

    Nawrot, Mark; Stroyan, Keith

    2012-04-15

    The perception of depth from relative motion is believed to be a slow process that "builds-up" over a period of observation. However, in the case of motion parallax, the potential accuracy of the depth estimate suffers as the observer translates during the viewing period. Our recent quantitative model for the perception of depth from motion parallax proposes that relative object depth (d) can be determined from retinal image motion (dθ/dt), pursuit eye movement (dα/dt), and fixation distance (f) by the formula: d/f≈dθ/dα. Given the model's dynamics, it is important to know the integration time required by the visual system to recover dα and dθ, and then estimate d. Knowing the minimum integration time reveals the incumbent error in this process. A depth-phase discrimination task was used to determine the time necessary to perceive depth-sign from motion parallax. Observers remained stationary and viewed a briefly translating random-dot motion parallax stimulus. Stimulus duration varied between trials. Fixation on the translating stimulus was monitored and enforced with an eye-tracker. The study found that relative depth discrimination can be performed with presentations as brief as 16.6 ms, with only two stimulus frames providing both retinal image motion and the stimulus window motion for pursuit (mean range=16.6-33.2 ms). This was found for conditions in which, prior to stimulus presentation, the eye was engaged in ongoing pursuit or the eye was stationary. A large high-contrast masking stimulus disrupted depth-discrimination for stimulus presentations less than 70-75 ms in both pursuit and stationary conditions. This interval might be linked to ocular-following response eye-movement latencies. We conclude that neural mechanisms serving depth from motion parallax generate a depth estimate much more quickly than previously believed. We propose that additional sluggishness might be due to the visual system's attempt to determine the maximum dθ/dα ratio

  3. Design considerations for a time-resolved tomographic diagnostic at DARHT

    International Nuclear Information System (INIS)

    Morris I. Kaufman, Daniel Frayer, Wendi Dreesen, Douglas Johnson, Alfred Meidinger

    2006-01-01

    An instrument has been developed to acquire time-resolved tomographic data from the electron beam at the DARHT [Dual-Axis Radiographic Hydrodynamic Test] facility at Los Alamos National Laboratory. The instrument contains four optical lines of sight that view a single tilted object. The lens design optically integrates along one optical axis for each line of sight. These images are relayed via fiber optic arrays to streak cameras, and the recorded streaks are used to reconstruct the original two-dimensional data. Installation of this instrument into the facility requires automation of both the optomechanical adjustments and calibration of the instrument in a constrained space. Additional design considerations include compound tilts on the object and image planes

  4. Integration of autonomous systems for remote control of data acquisition and diagnostics in the TJ-II device

    International Nuclear Information System (INIS)

    Vega, J.; Mollinedo, A.; Lopez, A.; Pacios, L.; Dormido, S.

    1997-01-01

    The data acquisition system for TJ-II will consist of a central computer, containing the data base of the device, and a set of independent systems (personal computers, embedded ones, workstations, minicomputers, PLCs, and microprocessor systems among others), controlling data collection, and automated diagnostics. Each autonomous system can be used to isolate and manage specific problems in the most efficient manner. These problems are related to data acquisition, hard (μs endash ms) real time requirements, soft (ms endash s) real time requirements, remote control of diagnostics, etc. In the operation of TJ-II, the programming of systems will be carried out from the central computer. Coordination and synchronization will be performed by linking systems to local area networks. Several Ethernet segments and FDDI rings will be used for these purposes. Programmable logic controller devices (PLCs) used for diagnostic low level control will be linked among them through a fast serial link, the RS485 Profibus standard. One VME crate, running on the OS-9 real time operating system, will be assigned as a gateway, so as to connect the PLCs based systems with an Ethernet segment. copyright 1997 American Institute of Physics

  5. On scattering diagnostics with periodically pulsed lasers to follow the continuous evolution of time dependent plasma parameters

    International Nuclear Information System (INIS)

    Hellermann, M. von; Hirsch, K.; Doeble, H.F.

    1977-04-01

    The possibilities to use periodically pulsed lasers for plasma scattering diagnostics are discussed. An experiment with succesful application of a periodically pulsed frequency-doubled Nd:YAG laser is described and results are given. Application of the method to monitor continuously, with millisecond time resolution, parameters of Tokamak type plasmas, is considered. (orig.) [de

  6. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

    NARCIS (Netherlands)

    van Grinsven, J. (Janneke); S. van Brunschot (Sandra); P. Fockens (Paul); J. van Grinsven (Janneke); O.J. Bakker (Olaf ); van Santvoort, H.C. (Hjalmar C.); T.L. Bollen (Thomas); M.A. Boermeester (Marja); C.H.J. van Eijck (Casper); M.G. Besselink (Marc); M.J. Bruno (Marco); C.H. Dejong (Cees); K.D. Horvath (Karen); van Eijck, C.H. (Casper H.); H. van Goor (Harry); H.G. Gooszen (Hein); Horvath, K.D. (Karen D.); K.P. van Lienden (Krijn); Abdelhafez, M.; Andersson, R.; Andren-Sandberg, A.; Ashley, S.; M.C. van Baal (Mark); Baron, T.; C. Bassi (Claudio); Bradley, E.; M.W. Buchler (M.); V.C. Cappendijk; Carter, R.; Charnley, R.; Coelho, D.; Connor, S.; Dellinger, P.; C. Dervenis (Christos); J. Devière (J.); Doctor, N.; Dudeja, V.; En-qiang, M.; Escourrou, J.; Fagenholz, P.; Farkas, G.; Forsmark, C.; Freeman, M.; P.C. Freeny (Patrick); French, J.; H. Friess; Gardner, T.; Goetzinger, P.; J.W. Haveman; S. Hofker (Sijbrand); Imrie, C.; Isaji, S.; Isenmann, R.; E. Klar (Ernst); J.S. Laméris (Johan ); M. Lerch (M.); P. Lévy (Philippe); Lillemoe, K.; Löhr, M.; J. Mayerle (Julia); Mayumi, T.; Mittal, A.; Moessner, J.; Morgan, D.; K.J. Mortele (Koenraad); Nealon, W.; J.P. Neoptolemos (John); V.B. Nieuwenhuijs (Vincent); Nordback, I.; Olah, A.; K. Oppong (K.); Padbury, R.; Papachristou, G.; Parks, R.; J.-W. Poley (Jan-Werner); Radenkovic, D.; Raraty, M.; Rau, B.; V. Rebours (Vinciane); Rische, S.; Runzi, M.; Sainani, N.; Sarr, M.; Schaapherder, S.; S. Seewald (Stefan); Seifert, H.; Shimosegawa, T.; Silverman, S.; Singh, V.; Siriwardena, A.; Steinberg, W.; Sutton, R.; Takeda, K.; R. Timmer (Robin); Vege, S.; R.P. Voermans (Rogier); J.J. De Waele (Jan J.); Wang, C. (Ch.); Warshaw, A.; J. Werner (Jens Martin); B.L. Weusten (Bas); Whitcomb, D.; Wig, J.; Windsor, J.; Zyromski, N.

    2016-01-01

    textabstractBackground The optimal diagnostic strategy and timing of intervention in infected necrotizing pancreatitis is subject to debate. We performed a survey on these topics amongst a group of international expert pancreatologists. Methods An online survey including case vignettes was sent to

  7. Diagnostic instrumentation aboard ISS: just-in-time training for non-physician crewmembers

    Science.gov (United States)

    Foale, C. Michael; Kaleri, Alexander Y.; Sargsyan, Ashot E.; Hamilton, Douglas R.; Melton, Shannon; Martin, David; Dulchavsky, Scott A.

    2005-01-01

    INTRODUCTION: The performance of complex tasks on the International Space Station (ISS) requires significant preflight crew training commitments and frequent skill and knowledge refreshment. This report documents a recently developed "just-in-time" training methodology, which integrates preflight hardware familiarization and procedure training with an on-orbit CD-ROM-based skill enhancement. This "just-in-time" concept was used to support real-time remote expert guidance to complete ultrasound examinations using the ISS Human Research Facility (HRF). METHODS: An American and Russian ISS crewmember received 2 h of "hands on" ultrasound training 8 mo prior to the on-orbit ultrasound exam. A CD-ROM-based Onboard Proficiency Enhancement (OPE) interactive multimedia program consisting of memory enhancing tutorials, and skill testing exercises, was completed by the crewmember 6 d prior to the on-orbit ultrasound exam. The crewmember was then remotely guided through a thoracic, vascular, and echocardiographic examination by ultrasound imaging experts. RESULTS: Results of the CD-ROM-based OPE session were used to modify the instructions during a complete 35-min real-time thoracic, cardiac, and carotid/jugular ultrasound study. Following commands from the ground-based expert, the crewmember acquired all target views and images without difficulty. The anatomical content and fidelity of ultrasound video were adequate for clinical decision making. CONCLUSIONS: Complex ultrasound experiments with expert guidance were performed with high accuracy following limited preflight training and multimedia based in-flight review, despite a 2-s communication latency. In-flight application of multimedia proficiency enhancement software, coupled with real-time remote expert guidance, facilitates the successful performance of ultrasound examinations on orbit and may have additional terrestrial and space applications.

  8. Integration of PET/CT in Current Diagnostic and Response Evaluation Methods in Patients with Tuberculosis

    International Nuclear Information System (INIS)

    Oezmen, Oelem; Goekcek, Atila; Tatci, Ebru; Biner, Inci; Akkalyoncu, Behiye

    2014-01-01

    Tuberculosis is a systemic disease that still affects many people. While pleural involvement is frequently observed in extrapulmonary tuberculosis, multiple skeletal system and articular involvements are quite rare. FDG PET imaging could be a promising diagnostic and treatment monitoring method, especially in complicated cases and if the other methods are inadequate. In this case study, we report a patient who was admitted with suspected malignancy and then diagnosed with tuberculosis pleuritis, lymphadenitis, spondylodiscitis, and sacroiliitis with specific symptoms; the response to anti-tuberculosis therapy was shown using FDG PET/CT

  9. Integration of PET/CT in Current Diagnostic and Response Evaluation Methods in Patients with Tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Oezmen, Oelem; Goekcek, Atila; Tatci, Ebru; Biner, Inci; Akkalyoncu, Behiye [Atatuerk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara (Turkmenistan)

    2014-03-15

    Tuberculosis is a systemic disease that still affects many people. While pleural involvement is frequently observed in extrapulmonary tuberculosis, multiple skeletal system and articular involvements are quite rare. FDG PET imaging could be a promising diagnostic and treatment monitoring method, especially in complicated cases and if the other methods are inadequate. In this case study, we report a patient who was admitted with suspected malignancy and then diagnosed with tuberculosis pleuritis, lymphadenitis, spondylodiscitis, and sacroiliitis with specific symptoms; the response to anti-tuberculosis therapy was shown using FDG PET/CT.

  10. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers

    International Nuclear Information System (INIS)

    Upadhyaya, Belle R.; Wesley Hines, J.

    2004-01-01

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001-September 2004. (1) Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. (2) Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance. (3) Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. (4) Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. (5) Development of advanced signal

  11. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers.

    Energy Technology Data Exchange (ETDEWEB)

    Belle R. Upadhyaya; J. Wesley Hines

    2004-09-27

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001-September 2004. (1) Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. (2) Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance. (3) Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. (4) Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. (5) Development of advanced signal

  12. Diagnostics of underwater electrical wire explosion through a time- and space-resolved hard x-ray source.

    Science.gov (United States)

    Sheftman, D; Shafer, D; Efimov, S; Gruzinsky, K; Gleizer, S; Krasik, Ya E

    2012-10-01

    A time- and space-resolved hard x-ray source was developed as a diagnostic tool for imaging underwater exploding wires. A ~4 ns width pulse of hard x-rays with energies of up to 100 keV was obtained from the discharge in a vacuum diode consisting of point-shaped tungsten electrodes. To improve contrast and image quality, an external pulsed magnetic field produced by Helmholtz coils was used. High resolution x-ray images of an underwater exploding wire were obtained using a sensitive x-ray CCD detector, and were compared to optical fast framing images. Future developments and application of this diagnostic technique are discussed.

  13. Diagnostic nerve ultrasonography

    International Nuclear Information System (INIS)

    Baeumer, T.; Grimm, A.; Schelle, T.

    2017-01-01

    For the diagnostics of nerve lesions an imaging method is necessary to visualize peripheral nerves and their surrounding structures for an etiological classification. Clinical neurological and electrophysiological investigations provide functional information about nerve lesions. The information provided by a standard magnetic resonance imaging (MRI) examination is inadequate for peripheral nerve diagnostics; however, MRI neurography is suitable but on the other hand a resource and time-consuming method. Using ultrasonography for peripheral nerve diagnostics. With ultrasonography reliable diagnostics of entrapment neuropathies and traumatic nerve lesions are possible. The use of ultrasonography for neuropathies shows that a differentiation between different forms is possible. Nerve ultrasonography is an established diagnostic tool. In addition to the clinical examination and clinical electrophysiology, structural information can be obtained, which results in a clear improvement in the diagnostics. Ultrasonography has become an integral part of the diagnostic work-up of peripheral nerve lesions in neurophysiological departments. Nerve ultrasonography is recommended for the diagnostic work-up of peripheral nerve lesions in addition to clinical and electrophysiological investigations. It should be used in the clinical work-up of entrapment neuropathies, traumatic nerve lesions and spacy-occupying lesions of nerves. (orig.) [de

  14. A "package solution" fast track program can reduce the diagnostic waiting time in head and neck cancer

    DEFF Research Database (Denmark)

    Sørensen, Jesper Roed; Johansen, Jørgen; Gano, Lars

    2014-01-01

    and Neck Surgery during three comparable time intervals 2006-2007, 2007-2008, and 2011-2012 (groups 1-3) were investigated. We recorded the time from patient referral, to first consultation and final diagnosis. The first interval was before initiation of the "package solution", the second just after......In 2007, a fast track program for patients with suspicion of head and neck cancer (HNC) was introduced in Denmark to reduce unnecessary waiting time. The program was based on so called "package solutions" including pre-booked slots for outpatient evaluation, imaging, and diagnostic surgical...... procedures. The purpose of this study is to present a model for fast track handling of patients suspicious of cancer in the head and neck region and to evaluate the effect of implementation on the diagnostic work up time. Patients with suspicion of HNC referred to the same university department of ENT Head...

  15. It's time to change perspective! New diagnostic tools for lateral elbow pain.

    Science.gov (United States)

    Arrigoni, P; Cucchi, D; Menon, A; Randelli, P

    2017-12-01

    The presence of intra-articular findings that may complement the extra-articular pathology in lateral epicondilytis has been suggested, and a role for minor instability of the elbow as part of the causative process of this disease has been postulated. This study was designed to describe two new clinical tests, aimed at detecting intra-articular pathology in patients affected by recalcitrant lateral epicondylitis and investigate their diagnostic performance. Ten patients suffering of atraumatic lateral elbow pain unresponsive to conservative treatment were considered in this study. Two clinical tests were developed and administrated prior to arthroscopy: Supination and Antero-Lateral pain Test (SALT); Posterior Elbow Pain by Palpation-Extension of the Radiocapitellar joint (PEPPER). Sensitivity, specificity, predictive values and accuracy of SALT and PEPPER as diagnostic tests for seven intra-articular findings were calculated. In 90% of the patients, at least one test was positive. All patients with signs of lateral ligamentous patholaxity or intra-articular abnormal findings had a positive response to at least one of the two tests. SALT proved to have a high sensitivity but a low specificity and is accurate in detecting the presence of intra-articular abnormal findings, especially synovitis. PEPPER test was sensible, specific and accurate in the detection of radial head chondropathy. Two new diagnostic tests (SALT and PEPPER) were specifically designed to evoke pain from intra-articular structures. These tests could be a valid support in the diagnostic algorithm of recalcitrant lateral elbow pain. Positive findings may be indicative of a minor instability of the lateral elbow condition. Diagnostic study, development of diagnostic criteria on basis of consecutive patients, level II.

  16. Performance of a real-time PCR assay in routine bovine mastitis diagnostics compared with in-depth conventional culture.

    Science.gov (United States)

    Hiitiö, Heidi; Riva, Rauna; Autio, Tiina; Pohjanvirta, Tarja; Holopainen, Jani; Pyörälä, Satu; Pelkonen, Sinikka

    2015-05-01

    Reliable identification of the aetiological agent is crucial in mastitis diagnostics. Real-time PCR is a fast, automated tool for detecting the most common udder pathogens directly from milk. In this study aseptically taken quarter milk samples were analysed with a real-time PCR assay (Thermo Scientific PathoProof Mastitis Complete-12 Kit, Thermo Fisher Scientific Ltd.) and by semi-quantitative, in-depth bacteriological culture (BC). The aim of the study was to evaluate the diagnostic performance of the real-time PCR assay in routine use. A total of 294 quarter milk samples from routine mastitis cases were cultured in the national reference laboratory of Finland and examined with real-time PCR. With BC, 251 out of 294 (85.7%) of the milk samples had at least one colony on the plate and 38 samples were considered contaminated. In the PCR mastitis assay, DNA of target species was amplified in 244 samples out of 294 (83.0%). The most common bacterial species detected in the samples, irrespective of the diagnostic method, was the coagulase negative staphylococci (CNS) group (later referred as Staphylococcus spp.) followed by Staphylococcus aureus. Sensitivity (Se) and specificity (Sp) for the PCR assay to provide a positive Staph. aureus result was 97.0 and 95.8% compared with BC. For Staphylococcus spp., the corresponding figures were 86.7 and 75.4%. Our results imply that PCR performed well as a diagnostic tool to detect Staph. aureus but may be too nonspecific for Staphylococcus spp. in routine use with the current cut-off Ct value (37.0). Using PCR as the only microbiological method for mastitis diagnostics, clinical relevance of the results should be carefully considered before further decisions, for instance antimicrobial treatment, especially when minor pathogens with low amount of DNA have been detected. Introducing the concept of contaminated samples should also be considered.

  17. Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine

    Directory of Open Access Journals (Sweden)

    Todd T. Schlegel

    2013-08-01

    Full Text Available It is undeniable that the increasing costs in healthcare are a concern. Although technological advancements have been made in healthcare systems, the return on investment made by governments and payers has been poor. The current model of care is unsustainable and is due for an upgrade. In developed nations, a law of diminishing returns has been noted in population health standards, whilst in the developing world, westernized chronic illnesses, such as diabetes and cardiovascular disease have become emerging problems. The reasons for these trends are complex, multifactorial and not easily reversed. Personalized medicine has the potential to have a significant impact on these issues, but for it to be truly successful, interdisciplinary mass collaboration is required. We propose here a vision for open-access advanced analytics for personalized cardiac diagnostics using imaging, electrocardiography and genomics.

  18. Impact of the diagnostic process on the accuracy of source identification and time to antibiotics in septic emergency department patients.

    Science.gov (United States)

    Uittenbogaard, Annemieke J M; de Deckere, Ernie R J T; Sandel, Maro H; Vis, Alice; Houser, Christine M; de Groot, Bas

    2014-06-01

    Timely administration of effective antibiotics is important in sepsis management. Source-targeted antibiotics are believed to be most effective, but source identification could cause time delays. First, to describe the accuracy/time delays of a diagnostic work-up and the association with time to antibiotics in septic emergency department (ED) patients. Second, to assess the fraction in which source-targeted antibiotics could have been administered solely on the basis of patient history and physical examination. Secondary analysis of the prospective observational study on septic ED patients was carried out. The time to test result availability was associated with time to antibiotics. The accuracy of the suspected source of infection in the ED was assessed. For patients with pneumosepsis, urosepsis, and abdominal sepsis, combinations of signs and symptoms were assessed to achieve a maximal positive predictive value for the sepsis source, identifying a subset of patients in whom source-targeted antibiotics could be administered without waiting for diagnostic test results. The time to antibiotics increased by 18 (95% confidence interval: 12-24) min/h delay in test result availability (n=323). In 38-79% of patients, antibiotics were administered after additional tests, whereas the ED diagnosis was correct in 68-85% of patients. The maximal positive predictive value of signs and symptoms was 0.87 for patients with pneumosepsis and urosepsis and 0.75 for those with abdominal sepsis. Use of signs and symptoms would have led to correct ED diagnosis in 33% of patients. Diagnostic tests are associated with delayed administration of antibiotics to septic ED patients while increasing the diagnostic accuracy to only 68-85%. In one-third of septic ED patients, the choice of antibiotics could have been accurately determined solely on the basis of patient history and physical examination.

  19. Timing sensory integration for robot simulation of autistic behavior

    NARCIS (Netherlands)

    Barakova, E.I.; Chonnaparamutt, W.

    2009-01-01

    The experiments in this paper show that the impact of temporal aspects of sensory integration on the precision of movement is concordant with behavioral studies of sensory integrative dysfunction and autism. Specifically, the simulation predicts that distant grasping will be performed properly by

  20. Optimal Real-time Dispatch for Integrated Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan Michael [Univ. of California, Berkeley, CA (United States)

    2007-05-31

    This report describes the development and application of a dispatch optimization algorithm for integrated energy systems (IES) comprised of on-site cogeneration of heat and electricity, energy storage devices, and demand response opportunities. This work is intended to aid commercial and industrial sites in making use of modern computing power and optimization algorithms to make informed, near-optimal decisions under significant uncertainty and complex objective functions. The optimization algorithm uses a finite set of randomly generated future scenarios to approximate the true, stochastic future; constraints are included that prevent solutions to this approximate problem from deviating from solutions to the actual problem. The algorithm is then expressed as a mixed integer linear program, to which a powerful commercial solver is applied. A case study of United States Postal Service Processing and Distribution Centers (P&DC) in four cities and under three different electricity tariff structures is conducted to (1) determine the added value of optimal control to a cogeneration system over current, heuristic control strategies; (2) determine the value of limited electric load curtailment opportunities, with and without cogeneration; and (3) determine the trade-off between least-cost and least-carbon operations of a cogeneration system. Key results for the P&DC sites studied include (1) in locations where the average electricity and natural gas prices suggest a marginally profitable cogeneration system, optimal control can add up to 67% to the value of the cogeneration system; optimal control adds less value in locations where cogeneration is more clearly profitable; (2) optimal control under real-time pricing is (a) more complicated than under typical time-of-use tariffs and (b) at times necessary to make cogeneration economic at all; (3) limited electric load curtailment opportunities can be more valuable as a compliment to the cogeneration system than alone; and

  1. Real time diagnostic for operation at a CW low voltage FEL

    Energy Technology Data Exchange (ETDEWEB)

    Balfour, C.; Shaw, A.; Mayhew, S.E. [and others

    1995-12-31

    At Liverpool University, a system for single user control of an FEL has been designed to satisfy the low voltage FEL (ie 200kV) operational requirements. This system incorporates many aspects of computer automation for beam diagnostics, radiation detection and vacuum system management. In this paper the results of the development of safety critical control systems critical control systems are reported.

  2. Identification of real-time diagnostic measures of visual distraction with an automatic eye-tracking system.

    Science.gov (United States)

    Zhang, Harry; Smith, Matthew R H; Witt, Gerald J

    2006-01-01

    This study was conducted to identify eye glance measures that are diagnostic of visual distraction. Visual distraction degrades performance, but real-time diagnostic measures have not been identified. In a driving simulator, 14 participants responded to a lead vehicle braking at -2 or -2.7 m/s2 periodically while reading a varying number of words (6-15 words every 13 s) on peripheral displays (with diagonal eccentricities of 24 degrees, 43 degrees, and 75 degrees). As the number of words and display eccentricity increased, total glance duration and reaction time increased and driving performance suffered. Correlation coefficients between several glance measures and reaction time or performance variables were reliably high, indicating that these glance measures are diagnostic of visual distraction. It is predicted that for every 25% increase in total glance duration, reaction time is increased by 0.39 s and standard deviation of lane position is increased by 0.06 m. Potential applications of this research include assessing visual distraction in real time, delivering advisories to distracted drivers to reorient their attention to driving, and using distraction information to adapt forward collision and lane departure warning systems to enhance system effectiveness.

  3. Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

    KAUST Repository

    Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

    2015-01-01

    Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

  4. Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

    KAUST Repository

    Sayed, Sadeed Bin

    2015-05-16

    Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

  5. The relationship between waiting times and 'adherence' to the Scottish Intercollegiate Guidelines Network 98 guideline in autism spectrum disorder diagnostic services in Scotland.

    Science.gov (United States)

    McKenzie, Karen; Forsyth, Kirsty; O'Hare, Anne; McClure, Iain; Rutherford, Marion; Murray, Aja; Irvine, Linda

    2016-05-01

    The aim of this study was to explore the extent to which the Scottish Intercollegiate Guidelines Network 98 guidelines on the assessment and diagnosis of autism spectrum disorder were adhered to in child autism spectrum disorder diagnostic services in Scotland and whether there was a significant relationship between routine practice which more closely reflected these recommendations (increased adherence) and increased waiting times. Retrospective, cross-sectional case note analysis was applied to data from 80 case notes. Adherence ranged from a possible 0 (no adherence) to 19 (full adherence). Overall, 17/22 of the recommendations were adhered to in over 50 of the 80 cases and in 70 or more cases for 11/22 of the recommendations, with a mean adherence score of 16 (standard deviation = 1.9). No significant correlation was found between adherence and total wait time for untransformed (r = 0.15, p = 0.32) or transformed data (r = 0.12, p = 0.20). The results indicated that the assessment and diagnostic practices were consistent with the relevant Scottish Intercollegiate Guidelines Network 98 guideline recommendations. Increased adherence to the 19 included recommendations was not significantly related to increased total waiting times, indicating that the Scottish Intercollegiate Guidelines Network 98 recommendations have generally been integrated into practice, without a resultant increase in patient waits. © The Author(s) 2015.

  6. New design for photonic temporal integration with combined high processing speed and long operation time window.

    Science.gov (United States)

    Asghari, Mohammad H; Park, Yongwoo; Azaña, José

    2011-01-17

    We propose and experimentally prove a novel design for implementing photonic temporal integrators simultaneously offering a high processing bandwidth and a long operation time window, namely a large time-bandwidth product. The proposed scheme is based on concatenating in series a time-limited ultrafast photonic temporal integrator, e.g. implemented using a fiber Bragg grating (FBG), with a discrete-time (bandwidth limited) optical integrator, e.g. implemented using an optical resonant cavity. This design combines the advantages of these two previously demonstrated photonic integrator solutions, providing a processing speed as high as that of the time-limited ultrafast integrator and an operation time window fixed by the discrete-time integrator. Proof-of-concept experiments are reported using a uniform fiber Bragg grating (as the original time-limited integrator) connected in series with a bulk-optics coherent interferometers' system (as a passive 4-points discrete-time photonic temporal integrator). Using this setup, we demonstrate accurate temporal integration of complex-field optical signals with time-features as fast as ~6 ps, only limited by the processing bandwidth of the FBG integrator, over time durations as long as ~200 ps, which represents a 4-fold improvement over the operation time window (~50 ps) of the original FBG integrator.

  7. Diagnostic efficacy of standard knee magnetic resonance imaging and radiography in evaluating integrity of anterior cruciate ligament before unicompartmental knee arthroplasty.

    Science.gov (United States)

    Altınel, Levent; Er, Mehmet Serhan; Kaçar, Emre; Erten, Recep Abdullah

    2015-01-01

    The purpose of this study was to investigate the diagnostic efficacy of standard magnetic resonance imaging (MRI) and plain radiographs in determining the status of anterior cruciate ligament (ACL) for surgical decision-making processes in cases of medial unicompartmental knee arthroplasty (UKA). A total of 59 knees of 36 consecutive patients who underwent knee replacement surgery were analyzed retrospectively. MRI scans were assessed independently by 3 observers (radiologists), while the plain radiographs were evaluated by an independent radiologist. Results were compared with the intraoperative ACL status. Cross tabulation was used for descriptive statistics to analyze sensitivity, specificity, and accuracy of MRI and plain radiographs. When the same observer assessed and classified the MRI twice, the reproducibility of the classification system varied from moderate to excellent. However, the interobserver concordance was moderate. The sensitivity of MRI was 73% and the specificity was 81%, while the sensitivity and specificity of plain radiographs was 36% and 79%, respectively. The accuracy of MRI was 80%, while that of the radiographs was 71%. Detection of intact ACL may be possible on available plain radiographs without necessity for additional means such as MRI, which may cause increase costs and loss of time. In cases where there is uncertainty regarding ACL integrity in degenerative knees, although standard MRI provides additional information on ACL status, it is not of sufficient diagnostic value.

  8. Real Time Polymerase Chain Reaction : Perangkat Diagnostic Alternatif untuk Melacak Virus Nipah (REAL TIME POLYMERASE CHAIN REACTION : AN ALTERNATIVE DIAGNOSTIC TOOL TO DETECT NIPAH VIRUS

    Directory of Open Access Journals (Sweden)

    Indrawati Sendow

    2014-05-01

    Full Text Available Nipah is a dangerous zoonotic disease with a high social, economical and psychological impact. Fruitbat Pteropus sp. is one of the nipah virus  reservoir host. As the virus is categorized as a dangerous zoonoticdisease that cause fatal in human, all works related to live virus should be conducted in a laboratory withBSL4 facilities. The detection of nipah virus using real time PCR to replace virus isolastion can thereforebe conducted in a laboratory without BSL4 facilities. The results was further  confirmed at referencelaboratory at   Australian Animal Health Laboratory ( AAHL Geelong, Australia, indicated that nipahvirus can be detected in saliva of fruit bat P. vampyrus in Medan North Sumatera.

  9. Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process.

    Science.gov (United States)

    Wienert, Stephan; Beil, Michael; Saeger, Kai; Hufnagl, Peter; Schrader, Thomas

    2009-01-09

    The virtual microscopy is widely accepted in Pathology for educational purposes and teleconsultation but is far from the routine use in surgical pathology due to the technical requirements and some limitations. A technical problem is the limited bandwidth of a usual network and the delayed transmission rate and presentation time on the screen. In this study the process of secondary diagnostic was evaluated using the "T.Konsult Pathologie" service of the Professional Association of German Pathologists within the German breast cancer screening program. The characteristics of the access to the WSI (Whole Slide Images) have been analyzed to explore the possibilities of prefetching and caching to reduce the presentation and transfer time with the goal to increase user acceptance. The log files of the web server were analyzed to reconstruct the movements of the pathologist on the WSI and to create the observation path. Using a specialized tool the observation paths were extracted automatically from the log files. The attributes linearity, 3-point-linearity, changes per request, and number of consecutive requests were calculated to design, develop and evaluate different caching and prefetching strategies. The analysis of the observation paths showed that a complete accordance of two image requests is a very rare event. But more frequently a partial covering of two requested image areas can be found. In total 257 diagnostic paths from 131 WSI have been extracted and analysed. On average a diagnostic path consists of 16 image requests and takes 189 seconds between first and last image request. The mean linearity was 0,41 and the mean 3-point-linearity 0,85. Three different caching algorithms have been compared with respect to hit rate and additional image requests on the WSI server. Tests demonstrated that 95% of the diagnostic paths could be loaded without any deletion of entries in the cache (cache size 12,2 Megapixel). If the image parts are stored after JPEG compression

  10. Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process

    Directory of Open Access Journals (Sweden)

    Hufnagl Peter

    2009-01-01

    Full Text Available Abstract Background The virtual microscopy is widely accepted in Pathology for educational purposes and teleconsultation but is far from the routine use in surgical pathology due to the technical requirements and some limitations. A technical problem is the limited bandwidth of a usual network and the delayed transmission rate and presentation time on the screen. Methods In this study the process of secondary diagnostic was evaluated using the "T.Konsult Pathologie" service of the Professional Association of German Pathologists within the German breast cancer screening program. The characteristics of the access to the WSI (Whole Slide Images have been analyzed to explore the possibilities of prefetching and caching to reduce the presentation and transfer time with the goal to increase user acceptance. The log files of the web server were analyzed to reconstruct the movements of the pathologist on the WSI and to create the observation path. Using a specialized tool the observation paths were extracted automatically from the log files. The attributes linearity, 3-point-linearity, changes per request, and number of consecutive requests were calculated to design, develop and evaluate different caching and prefetching strategies. Results The analysis of the observation paths showed that a complete accordance of two image requests is a very rare event. But more frequently a partial covering of two requested image areas can be found. In total 257 diagnostic paths from 131 WSI have been extracted and analysed. On average a diagnostic path consists of 16 image requests and takes 189 seconds between first and last image request. The mean linearity was 0,41 and the mean 3-point-linearity 0,85. Three different caching algorithms have been compared with respect to hit rate and additional image requests on the WSI server. Tests demonstrated that 95% of the diagnostic paths could be loaded without any deletion of entries in the cache (cache size 12,2 Megapixel

  11. Real-time Modelling, Diagnostics and Optimised MPPT for Residential PV Systems

    DEFF Research Database (Denmark)

    Sera, Dezso

    responsible for yield-reduction of residential photovoltaic systems. Combining the model calculations with measurements, a method to detect changes in the panels’ series resistance based on the slope of the I − V curve in the vicinity of open-circuit conditions and scaled to Standard Test Conditions (STC......The work documented in the thesis has been focused into two main sections. The first part is centred around Maximum Power Point Tracking (MPPT) techniques for photovoltaic arrays, optimised for fast-changing environmental conditions, and is described in Chapter 2. The second part is dedicated...... to diagnostic functions as an additional tool to maximise the energy yield of photovoltaic arrays (Chapter 4). Furthermore, mathematical models of PV panels and arrays have been developed and built (detailed in Chapter 3) for testing MPPT algorithms, and for diagnostic purposes. In Chapter 2 an overview...

  12. Diagnostic Criteria, Classification and Treatment Goals in Multiple Sclerosis: The Chronicles of Time and Space.

    Science.gov (United States)

    Ntranos, Achilles; Lublin, Fred

    2016-10-01

    Multiple sclerosis (MS) is one of the most diverse human diseases. Since its first description by Charcot in the nineteenth century, the diagnostic criteria, clinical course classification, and treatment goals for MS have been constantly revised and updated to improve diagnostic accuracy, physician communication, and clinical trial design. These changes have improved the clinical outcomes and quality of life for patients with the disease. Recent technological and research breakthroughs will almost certainly further change how we diagnose, classify, and treat MS in the future. In this review, we summarize the key events in the history of MS, explain the reasoning behind the current criteria for MS diagnosis, classification, and treatment, and provide suggestions for further improvements that will keep enhancing the clinical practice of MS.

  13. Women in post-trafficking services in moldova: diagnostic interviews over two time periods to assess returning women's mental health

    Directory of Open Access Journals (Sweden)

    Gorceag Lilia T

    2011-04-01

    Full Text Available Abstract Background Trafficking in women is a widespread human rights violation commonly associated with poor mental health. Yet, to date, no studies have used psychiatric diagnostic assessment to identify common forms of mental distress among survivors returning to their home country. Methods A longitudinal study was conducted of women aged 18 and over who returned to Moldova between December 2007 and December 2008 registered by the International Organisation for Migration as a survivor of human trafficking. Psychiatric diagnoses in women at a mean of 6 months after return (range 2-12 months were made by a trained Moldavian psychiatrist using the Structured Clinical Interview for DSM-IV, and compared with diagnoses recorded in the same women within 5 days of return. We described the socio-demographic characteristics of the women in the sample including both pre and post-trafficking information. We then described the distribution of mental health diagnoses recorded during the crisis intervention phase (1-5 days after return and the re-integration phase (2-12 months after return. We compared diagnoses at the patient level between the two time points by tabulating the diagnoses and carrying out a kappa test of agreement and the Stuart-Maxwell test for marginal homogeneity (an extension of the McNemar test to kxk table. Results 120/176 (68% eligible women participated. At 2-12 months after their return, 54% met criteria for at least one psychiatric diagnoses comprising post-traumatic stress disorder (PTSD alone (16%; co-morbid PTSD (20%; other anxiety or mood disorder (18%. 85% of women who had been diagnosed in the crisis phase with co-morbid PTSD or with another anxiety or mood disorder sustained a diagnosis of any psychiatric disorder when followed up during rehabilitation. Conclusions Trafficked women returning to their country of origin are likely to suffer serious psychological distress that may endure well beyond the time they return. Women

  14. Time of Flight based diagnostics for high energy laser driven ion beams

    Science.gov (United States)

    Scuderi, V.; Milluzzo, G.; Alejo, A.; Amico, A. G.; Booth, N.; Cirrone, G. A. P.; Doria, D.; Green, J.; Kar, S.; Larosa, G.; Leanza, R.; Margarone, D.; McKenna, P.; Padda, H.; Petringa, G.; Pipek, J.; Romagnani, L.; Romano, F.; Schillaci, F.; Borghesi, M.; Cuttone, G.; Korn, G.

    2017-03-01

    Nowadays the innovative high power laser-based ion acceleration technique is one of the most interesting challenges in particle acceleration field, showing attractive characteristics for future multidisciplinary applications, including medical ones. Nevertheless, peculiarities of optically accelerated ion beams make mandatory the development of proper transport, selection and diagnostics devices in order to deliver stable and controlled ion beams for multidisciplinary applications. This is the main purpose of the ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) beamline that will be realized and installed within 2018 at the ELI-Beamlines research center in the Czech Republic, where laser driven high energy ions, up to 60 MeV/n, will be available for users. In particular, a crucial role will be played by the on-line diagnostics system, recently developed in collaboration with INFN-LNS (Italy), consisting of TOF detectors, placed along the beamline (at different detection distances) to provide online monitoring of key characteristics of delivered beams, such as energy, fluence and ion species. In this contribution an overview on the ELIMAIA available ion diagnostics will be briefly given along with the preliminary results obtained during a test performed with high energy laser-driven proton beams accelerated at the VULCAN PW-laser available at RAL facility (U.K.).

  15. Time of Flight based diagnostics for high energy laser driven ion beams

    International Nuclear Information System (INIS)

    Scuderi, V.; Margarone, D.; Schillaci, F.; Milluzzo, G.; Amico, A.G.; Cirrone, G.A.P.; Larosa, G.; Leanza, R.; Petringa, G.; Pipek, J.; Romano, F.; Alejo, A.; Doria, D.; Kar, S.; Borghesi, M.; Booth, N.; Green, J.; McKenna, P.; Padda, H.; Romagnani, L.

    2017-01-01

    Nowadays the innovative high power laser-based ion acceleration technique is one of the most interesting challenges in particle acceleration field, showing attractive characteristics for future multidisciplinary applications, including medical ones. Nevertheless, peculiarities of optically accelerated ion beams make mandatory the development of proper transport, selection and diagnostics devices in order to deliver stable and controlled ion beams for multidisciplinary applications. This is the main purpose of the ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) beamline that will be realized and installed within 2018 at the ELI-Beamlines research center in the Czech Republic, where laser driven high energy ions, up to 60 MeV/n, will be available for users. In particular, a crucial role will be played by the on-line diagnostics system, recently developed in collaboration with INFN-LNS (Italy), consisting of TOF detectors, placed along the beamline (at different detection distances) to provide online monitoring of key characteristics of delivered beams, such as energy, fluence and ion species. In this contribution an overview on the ELIMAIA available ion diagnostics will be briefly given along with the preliminary results obtained during a test performed with high energy laser-driven proton beams accelerated at the VULCAN PW-laser available at RAL facility (U.K.).

  16. An electro-optical timing diagnostic for pump-probe experiments at the free-electron laser in Hamburg FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Azima, Armin

    2009-07-15

    Femtosecond pump-probe experiments have extensively been used to follow atomic and molecular motion in time. The very intense extreme ultraviolet XUV light of the Free electron LASer in Hamburg FLASH facility allows to investigate fundamental processes such as direct one or few photon inner shell ionizations. A supplementary Ti:Sapphire near infrared femtosecond laser system allows to perform two-color pump-probe experiments with FLASH involving intense laser fields of hugely different photon energies. Within this work a bunch arrival measurement system has been built, which assists these two-color pump-probe experiments to reduce the temporal jitter of FLASH and to increase the temporal resolution. The diagnostic is based upon an electro-optical detection scheme and measures the relative arrival time between the Ti:Sapphire femtosecond pulse and the electron bunch, which generates the self-amplified by stimulated emission SASE XUV pulse in the undulator section of FLASH. Key feature of the diagnostic is a 150 m long glass fiber pulse transport line, which inflicts non-linear dispersion. A dispersion control system to compensate for this higher order dispersion has been developed including the control and programming of a spatial light phase modulator. It was possible to transport a 90 fs FWHM short near infrared femtosecond laser pulse Fourier limited by the dispersion compensated glass fiber. The electro-optical signal induced by the FLASH electron bunch was generated, characterized and optimized. The signal features beside the designated bunch arrival timing capability the additional possibility to measure the longitudinal electron bunch density distribution of an arbitrary bunch of FLASH in a single shot with a temporal resolution of below 100 fs RMS. Timing and bunch analysis capabilities of the developed diagnostic have been cross-checked with other comparable diagnostics at FLASH like the transversal deflecting cavity structure named LOLA. Finally, the

  17. An electro-optical timing diagnostic for pump-probe experiments at the free-electron laser in Hamburg FLASH

    International Nuclear Information System (INIS)

    Azima, Armin

    2009-07-01

    Femtosecond pump-probe experiments have extensively been used to follow atomic and molecular motion in time. The very intense extreme ultraviolet XUV light of the Free electron LASer in Hamburg FLASH facility allows to investigate fundamental processes such as direct one or few photon inner shell ionizations. A supplementary Ti:Sapphire near infrared femtosecond laser system allows to perform two-color pump-probe experiments with FLASH involving intense laser fields of hugely different photon energies. Within this work a bunch arrival measurement system has been built, which assists these two-color pump-probe experiments to reduce the temporal jitter of FLASH and to increase the temporal resolution. The diagnostic is based upon an electro-optical detection scheme and measures the relative arrival time between the Ti:Sapphire femtosecond pulse and the electron bunch, which generates the self-amplified by stimulated emission SASE XUV pulse in the undulator section of FLASH. Key feature of the diagnostic is a 150 m long glass fiber pulse transport line, which inflicts non-linear dispersion. A dispersion control system to compensate for this higher order dispersion has been developed including the control and programming of a spatial light phase modulator. It was possible to transport a 90 fs FWHM short near infrared femtosecond laser pulse Fourier limited by the dispersion compensated glass fiber. The electro-optical signal induced by the FLASH electron bunch was generated, characterized and optimized. The signal features beside the designated bunch arrival timing capability the additional possibility to measure the longitudinal electron bunch density distribution of an arbitrary bunch of FLASH in a single shot with a temporal resolution of below 100 fs RMS. Timing and bunch analysis capabilities of the developed diagnostic have been cross-checked with other comparable diagnostics at FLASH like the transversal deflecting cavity structure named LOLA. Finally, the

  18. Prevalence and diagnostic performance of computed tomography angiography spot sign for intracerebral hematoma expansion depend on scan timing

    Energy Technology Data Exchange (ETDEWEB)

    Tsukabe, Akio; Watanabe, Yoshiyuki; Tanaka, Hisashi; Kunitomi, Yuki; Nishizawa, Mitsuo; Arisawa, Atsuko; Tomiyama, Noriyuki [Osaka University Graduate School of Medicine, Department of Diagnostic and Interventional Radiology, Suita, Osaka (Japan); Yoshiya, Kazuhisa; Shimazu, Takeshi [Osaka University Graduate School of Medicine, Department of Traumatology and Acute Critical Medicine, Suita, Osaka (Japan)

    2014-12-15

    The computed tomography angiography (CTA) spot sign correlates with intracerebral hemorrhage (ICH) expansion; however, various diagnostic performances for hematoma expansion, especially in sensitivity, have been reported. We aimed to assess the impact of scan timing of CTA on the diagnostic performance of the CTA spot sign for ICH expansion in two different arterial phases within patients. Eighty-three consecutive patients with primary ICH who received two sequential CTAs were recruited. Two neuroradiologists reviewed CTAs for CTA spot signs, while one reviewed initial and follow-up non-contrast CT for measuring ICH volume. The time interval between two phases was then calculated, and the diagnostic performance of CTA spot sign in each phase was evaluated. CTA spot signs were observed in 20/83 (24.1 %) patients in the early phase and 44/83 (53.0 %) patients in the late phase. The mean time interval between the two phases was 12.7 s. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for hematoma progression of CTA spot sign were 48.1, 87.5, 65.0, 77.8, and 74.7 %, respectively, in early phase and 92.6, 66.1, 56.8, 94.9, and 74.7 %, respectively, in late phase. The CTA spot sign was significantly associated with ICH expansion in early (P < 0.001) and late (P < 0.00001) phases (Pearson's chi-square test). A mere 10-s difference in scan timing could make a difference on prevalence and diagnostic performance of the CTA spot sign, suggesting a need for the standardization of the CTA protocol to generalize the approach for effective clinical application. (orig.)

  19. National Ignition Facility sub-system design requirements integrated timing system SSDR 1.5.3

    International Nuclear Information System (INIS)

    Wiedwald, J.; Van Aersau, P.; Bliss, E.

    1996-01-01

    This System Design Requirement document establishes the performance, design, development, and test requirements for the Integrated Timing System, WBS 1.5.3 which is part of the NIF Integrated Computer Control System (ICCS). The Integrated Timing System provides all temporally-critical hardware triggers to components and equipment in other NIF systems

  20. How well do time-integrated Kα images represent hot electron spatial distributions?

    Science.gov (United States)

    Ovchinnikov, V. M.; Kemp, G. E.; Schumacher, D. W.; Freeman, R. R.; Van Woerkom, L. D.

    2011-07-01

    A computational study is described, which addresses how well spatially resolved time-integrated Kα images recorded in intense laser-plasma experiments correlate with the distribution of "hot" (>1 MeV) electrons as they propagate through the target. The hot electron angular distribution leaving the laser-plasma region is critically important for many applications such as Fast Ignition or laser based x-ray sources; and Kα images are commonly used as a diagnostic. It is found that Kα images can easily mislead due to refluxing and other effects. Using the particle-in-cell code LSP, it is shown that a Kα image is not solely determined by the initial population of forward directed hot electrons, but rather also depends upon "delayed" hot electrons, and in fact continues to evolve long after the end of the laser interaction. Of particular note, there is a population of hot electrons created during the laser-plasma interaction that acquire a velocity direction opposite that of the laser and subsequently reflux off the front surface of the target, deflect when they encounter magnetic fields in the laser-plasma region, and then traverse the target in a wide spatial distribution. These delayed fast electrons create significant features in the Kα time-integrated images. Electrons refluxing from the sides and the back of the target are also found to play a significant role in forming the final Kα image. The relative contribution of these processes is found to vary depending on depth within target. These effects make efforts to find simple correlations between Kα images and, for example, Fast Ignition relevant parameters prone to error. Suggestions for future target design are provided.

  1. The integration of novel diagnostics techniques for multi-scale monitoring of large civil infrastructures

    Directory of Open Access Journals (Sweden)

    F. Soldovieri

    2008-11-01

    Full Text Available In the recent years, structural monitoring of large infrastructures (buildings, dams, bridges or more generally man-made structures has raised an increased attention due to the growing interest about safety and security issues and risk assessment through early detection. In this framework, aim of the paper is to introduce a new integrated approach which combines two sensing techniques acting on different spatial and temporal scales. The first one is a distributed optic fiber sensor based on the Brillouin scattering phenomenon, which allows a spatially and temporally continuous monitoring of the structure with a "low" spatial resolution (meter. The second technique is based on the use of Ground Penetrating Radar (GPR, which can provide detailed images of the inner status of the structure (with a spatial resolution less then tens centimetres, but does not allow a temporal continuous monitoring. The paper describes the features of these two techniques and provides experimental results concerning preliminary test cases.

  2. Diagnostic doses and times for Phlebotomus papatasi and Lutzomyia longipalpis sand flies (Diptera: Psychodidae: Phlebotominae) using the CDC bottle bioassay to assess insecticide resistance.

    Science.gov (United States)

    Denlinger, David S; Creswell, Joseph A; Anderson, J Laine; Reese, Conor K; Bernhardt, Scott A

    2016-04-15

    Insecticide resistance to synthetic chemical insecticides is a worldwide concern in phlebotomine sand flies (Diptera: Psychodidae), the vectors of Leishmania spp. parasites. The CDC bottle bioassay assesses resistance by testing populations against verified diagnostic doses and diagnostic times for an insecticide, but the assay has been used limitedly with sand flies. The objective of this study was to determine diagnostic doses and diagnostic times for laboratory Lutzomyia longipalpis (Lutz & Nieva) and Phlebotomus papatasi (Scopoli) to ten insecticides, including pyrethroids, organophosphates, carbamates, and DDT, that are used worldwide to control vectors. Bioassays were conducted in 1,000-ml glass bottles each containing 10-25 sand flies from laboratory colonies of L. longipalpis or P. papatasi. Four pyrethroids, three organophosphates, two carbamates and one organochlorine, were evaluated. A series of concentrations were tested for each insecticide, and four replicates were conducted for each concentration. Diagnostic doses were determined only during the exposure bioassay for the organophosphates and carbamates. For the pyrethroids and DDT, diagnostic doses were determined for both the exposure bioassay and after a 24-hour recovery period. Both species are highly susceptible to the carbamates as their diagnostic doses are under 7.0 μg/ml. Both species are also highly susceptible to DDT during the exposure assay as their diagnostic doses are 7.5 μg/ml, yet their diagnostic doses for the 24-h recovery period are 650.0 μg/ml for Lu. longipalpis and 470.0 μg/ml for P. papatasi. Diagnostic doses and diagnostic times can now be incorporated into vector management programs that use the CDC bottle bioassay to assess insecticide resistance in field populations of Lu. longipalpis and P. papatasi. These findings provide initial starting points for determining diagnostic doses and diagnostic times for other sand fly vector species and wild populations using the CDC

  3. On the relationship between supplier integration and time-to-market

    NARCIS (Netherlands)

    Perols, J.; Zimmermann, C.; Kortmann, S.

    2013-01-01

    Recent operations management and innovation management research emphasizes the importance of supplier integration. However, the empirical results as to the relationship between supplier integration and time-to-market are ambivalent. To understand this important relationship, we incorporate two major

  4. A discontinous Galerkin finite element method with an efficient time integration scheme for accurate simulations

    KAUST Repository

    Liu, Meilin; Bagci, Hakan

    2011-01-01

    A discontinuous Galerkin finite element method (DG-FEM) with a highly-accurate time integration scheme is presented. The scheme achieves its high accuracy using numerically constructed predictor-corrector integration coefficients. Numerical results

  5. Fully Integrated SAW-Less Discrete-Time Superheterodyne Receiver

    NARCIS (Netherlands)

    Madadi, I.

    2015-01-01

    There are nowadays strong business and technical demands to integrate radio- frequency (RF) receivers (RX) into a complete system-on-chip (SoC) realized in scaled digital processes technology. As a consequence, the RF circuitry has to function well in face of reduced power supply ( V DD ) while the

  6. From molecular imaging to systems diagnostics: Time for another paradigm shift?

    International Nuclear Information System (INIS)

    Li, King C.P.

    2009-01-01

    The term 'Molecular Imaging' has hit the consciousness of radiologists only in the past decade although many of the concepts that molecular imaging encompasses has been practiced in biomedical imaging, especially in nuclear medicine, for many decades. Many new imaging techniques have allowed us to interrogate biologic events at the cellular and molecular level in vivo in four dimensions but the challenge now is to translate these techniques into clinical practice in a way that will enable us to revolutionize healthcare delivery. The purpose of this article is to introduce the term 'Systems Diagnostics' and examine how radiologists can become translators of disparate sources of information into medical decisions and therapeutic actions.

  7. Time integration in the code Zgoubi and external usage of PTC's structures

    International Nuclear Information System (INIS)

    Forest, Etienne; Meot, F.

    2006-06-01

    The purpose of this note is to describe Zgoubi's integrator and to describe some pitfalls for time based integration when used in accelerators. We show why the convergence rate of an integrator can be affected by an improper treatment at the boundary when time is used as the integration variable. We also point out how the code PTC can be used as a container by other tracking engine. This work is not completed as far as incorporation of Zgoubi is concerned. (authors)

  8. Technical Performance Measurement, Earned Value, and Risk Management: An Integrated Diagnostic Tool for Program Management

    National Research Council Canada - National Science Library

    Pisano, N

    2002-01-01

    ...(A)), is known as the Navy PEO(A) Technical Performance Measurement (TPM) System. A retrospective analysis was conducted on the T45TS Cockpit-21 program and real-time test implementations are being conducted on the Federal Aviation Administration's (FAA...

  9. Diagnostics of microdischarge-integrated plasma sources for display and materials processing

    International Nuclear Information System (INIS)

    Tachibana, K; Kishimoto, Y; Kawai, S; Sakaguchi, T; Sakai, O

    2005-01-01

    Two different types of microdischarge-integrated plasma sources have been operated at around the atmospheric pressure range. The discharge characteristics were diagnosed by optical emission spectroscopy (OES), laser absorption spectroscopy (LAS) and microwave transmission (MT) techniques. The dynamic spatiotemporal behaviour of excited atoms was analysed using OES and LAS and the temporal behaviour of the electron density was estimated using the MT method. In Ar and Xe/Ne gases, waveforms of the MT signal followed the current waveform in the rise period and lasted longer according to the recombination losses. However, in He the waveform followed the density of metastable atoms, reflecting the production of a large amount of electrons by the Penning ionization process with impurities. The estimated peak electron density in those plasma sources is of the order of 10 12 cm -3 , and the metastable atom density can reach 10 13 cm -3 . Thus, it is suggested that these sources can be potentially applied to convenient material processing tools of large area operated stably at atmospheric pressure

  10. Integration of 3d Models and Diagnostic Analyses Through a Conservation-Oriented Information System

    Science.gov (United States)

    Mandelli, A.; Achille, C.; Tommasi, C.; Fassi, F.

    2017-08-01

    In the recent years, mature technologies for producing high quality virtual 3D replicas of Cultural Heritage (CH) artefacts has grown thanks to the progress of Information Technologies (IT) tools. These methods are an efficient way to present digital models that can be used with several scopes: heritage managing, support to conservation, virtual restoration, reconstruction and colouring, art cataloguing and visual communication. The work presented is an emblematic case of study oriented to the preventive conservation through monitoring activities, using different acquisition methods and instruments. It was developed inside a project founded by Lombardy Region, Italy, called "Smart Culture", which was aimed to realise a platform that gave the users the possibility to easily access to the CH artefacts, using as an example a very famous statue. The final product is a 3D reality-based model that contains a lot of information inside it, and that can be consulted through a common web browser. In the end, it was possible to define the general strategies oriented to the maintenance and the valorisation of CH artefacts, which, in this specific case, must consider the integration of different techniques and competencies, to obtain a complete, accurate and continuative monitoring of the statue.

  11. An Integrative Clinical Database and Diagnostics Platform for Biomarker Identification and Analysis in Ion Mobility Spectra of Human Exhaled Air

    Directory of Open Access Journals (Sweden)

    Schneider Till

    2013-06-01

    Full Text Available Over the last decade the evaluation of odors and vapors in human breath has gained more and more attention, particularly in the diagnostics of pulmonary diseases. Ion mobility spectrometry coupled with multi-capillary columns (MCC/IMS, is a well known technology for detecting volatile organic compounds (VOCs in air. It is a comparatively inexpensive, non-invasive, high-throughput method, which is able to handle the moisture that comes with human exhaled air, and allows for characterizing of VOCs in very low concentrations. To identify discriminating compounds as biomarkers, it is necessary to have a clear understanding of the detailed composition of human breath. Therefore, in addition to the clinical studies, there is a need for a flexible and comprehensive centralized data repository, which is capable of gathering all kinds of related information. Moreover, there is a demand for automated data integration and semi-automated data analysis, in particular with regard to the rapid data accumulation, emerging from the high-throughput nature of the MCC/IMS technology. Here, we present a comprehensive database application and analysis platform, which combines metabolic maps with heterogeneous biomedical data in a well-structured manner. The design of the database is based on a hybrid of the entity-attribute- value (EAV model and the EAV-CR, which incorporates the concepts of classes and relationships. Additionally it offers an intuitive user interface that provides easy and quick access to the platform’s functionality: automated data integration and integrity validation, versioning and roll-back strategy, data retrieval as well as semi-automatic data mining and machine learning capabilities. The platform will support MCC/IMS-based biomarker identification and validation. The software, schemata, data sets and further information is publicly available at http://imsdb.mpi-inf.mpg.de.

  12. Diagnostic performance of Schistosoma real-time PCR in urine samples from Kenyan children infected with Schistosoma haematobium

    DEFF Research Database (Denmark)

    Vinkeles Melchers, Natalie V. S.; van Dam, Govert J.; Shaproski, David

    2014-01-01

    treatment. METHODOLOGY: Previously collected urine samples (N = 390) from 114 preselected proven parasitological and/or clinical S. haematobium positive Kenyan schoolchildren were analyzed by a Schistosoma internal transcribed spacer-based real-time PCR after 14 years of storage. Pre-treatment day......, respectively. Based on the 'gold standard', PCR showed high sensitivity (>92%) as compared to >31% sensitivity for microscopy, both pre- and post-treatment. CONCLUSIONS/SIGNIFICANCE: Detection and quantification of Schistosoma DNA in urine by real-time PCR was shown to be a powerful and specific diagnostic...

  13. On the initial condition problem of the time domain PMCHWT surface integral equation

    KAUST Repository

    Uysal, Ismail Enes; Bagci, Hakan; Ergin, A. Arif; Ulku, H. Arda

    2017-01-01

    Non-physical, linearly increasing and constant current components are induced in marching on-in-time solution of time domain surface integral equations when initial conditions on time derivatives of (unknown) equivalent currents are not enforced

  14. Multigrid time-accurate integration of Navier-Stokes equations

    Science.gov (United States)

    Arnone, Andrea; Liou, Meng-Sing; Povinelli, Louis A.

    1993-01-01

    Efficient acceleration techniques typical of explicit steady-state solvers are extended to time-accurate calculations. Stability restrictions are greatly reduced by means of a fully implicit time discretization. A four-stage Runge-Kutta scheme with local time stepping, residual smoothing, and multigridding is used instead of traditional time-expensive factorizations. Some applications to natural and forced unsteady viscous flows show the capability of the procedure.

  15. CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics.

    Science.gov (United States)

    Gai, Xiaowu; Perin, Juan C; Murphy, Kevin; O'Hara, Ryan; D'arcy, Monica; Wenocur, Adam; Xie, Hongbo M; Rappaport, Eric F; Shaikh, Tamim H; White, Peter S

    2010-02-04

    Recent studies have shown that copy number variations (CNVs) are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. We developed a suite of software tools and resources (CNV Workshop) for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and is an ideal platform for coordinating multiple associated

  16. CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics

    Directory of Open Access Journals (Sweden)

    Rappaport Eric F

    2010-02-01

    Full Text Available Abstract Background Recent studies have shown that copy number variations (CNVs are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. Results We developed a suite of software tools and resources (CNV Workshop for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. Conclusions To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and

  17. System Integration for Real-time Mobile Manipulation

    OpenAIRE

    Oftadeh, Reza; Aref, Mohammad M.; Ghabcheloo, Reza; Mattila, Jouni

    2014-01-01

    Mobile manipulators are one of the most complicated types of mechatronics systems. The performance of these robots in performing complex manipulation tasks is highly correlated with the synchronization and integration of their low-level components. This paper discusses in detail the mechatronics design of a four wheel steered mobile manipulator. It presents the manipulator ’s mechanical structure and electrical interfaces, designs low-level software architecture based on embedded PC-based con...

  18. Knowledge Representation and Management, It's Time to Integrate!

    Science.gov (United States)

    Dhombres, F; Charlet, J

    2017-08-01

    Objectives: To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM). Methods: A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query. Results: Among the 1,421 retrieved papers, the review process resulted in the selection of four best papers focused on the integration of heterogeneous data via the development and the alignment of terminological resources. In the first article, the authors provide a curated and standardized version of the publicly available US FDA Adverse Event Reporting System. Such a resource will improve the quality of the underlying data, and enable standardized analyses using common vocabularies. The second article describes a project developed in order to facilitate heterogeneous data integration in the i2b2 framework. The originality is to allow users integrate the data described in different terminologies and to build a new repository, with a unique model able to support the representation of the various data. The third paper is dedicated to model the association between multiple phenotypic traits described within the Human Phenotype Ontology (HPO) and the corresponding genotype in the specific context of rare diseases (rare variants). Finally, the fourth paper presents solutions to annotation-ontology mapping in genome-scale data. Of particular interest in this work is the Experimental Factor Ontology (EFO) and its generic association model, the Ontology of Biomedical AssociatioN (OBAN). Conclusion: Ontologies have started to show their efficiency to integrate medical data for various tasks in medical informatics: electronic health records data management, clinical research, and knowledge-based systems development. Georg Thieme Verlag KG Stuttgart.

  19. Integrated Detection and Prediction of Influenza Activity for Real-Time Surveillance: Algorithm Design.

    Science.gov (United States)

    Spreco, Armin; Eriksson, Olle; Dahlström, Örjan; Cowling, Benjamin John; Timpka, Toomas

    2017-06-15

    Influenza is a viral respiratory disease capable of causing epidemics that represent a threat to communities worldwide. The rapidly growing availability of electronic "big data" from diagnostic and prediagnostic sources in health care and public health settings permits advance of a new generation of methods for local detection and prediction of winter influenza seasons and influenza pandemics. The aim of this study was to present a method for integrated detection and prediction of influenza virus activity in local settings using electronically available surveillance data and to evaluate its performance by retrospective application on authentic data from a Swedish county. An integrated detection and prediction method was formally defined based on a design rationale for influenza detection and prediction methods adapted for local surveillance. The novel method was retrospectively applied on data from the winter influenza season 2008-09 in a Swedish county (population 445,000). Outcome data represented individuals who met a clinical case definition for influenza (based on International Classification of Diseases version 10 [ICD-10] codes) from an electronic health data repository. Information from calls to a telenursing service in the county was used as syndromic data source. The novel integrated detection and prediction method is based on nonmechanistic statistical models and is designed for integration in local health information systems. The method is divided into separate modules for detection and prediction of local influenza virus activity. The function of the detection module is to alert for an upcoming period of increased load of influenza cases on local health care (using influenza-diagnosis data), whereas the function of the prediction module is to predict the timing of the activity peak (using syndromic data) and its intensity (using influenza-diagnosis data). For detection modeling, exponential regression was used based on the assumption that the beginning

  20. Diagnostic value of commercially available shear-wave elastography for breast cancers: integration into BI-RADS classification with subcategories of category 4.

    Science.gov (United States)

    Youk, Ji Hyun; Gweon, Hye Mi; Son, Eun Ju; Han, Kyung Hwa; Kim, Jeong-Ah

    2013-10-01

    To evaluate the diagnostic performance of shear-wave elastography (SWE) for breast cancer and to determine whether the integration of SWE into BI-RADS with subcategories of category 4 improves the diagnostic performance. A total of 389 breast masses (malignant 120, benign 269) in 324 women who underwent SWE before ultrasound-guided core biopsy or surgery were included. The qualitative SWE feature was assessed using a four-colour overlay pattern. Quantitative elasticity values including the lesion-to-fat elasticity ratio (Eratio) were measured. Diagnostic performance of B-mode ultrasound, SWE, or their combined studies was compared using the area under the ROC curve (AUC). AUC of Eratio (0.952) was the highest among elasticity values (mean, maximum, and minimum elasticity, 0.949, 0.939, and 0.928; P = 0.04) and AUC of colour pattern was 0.947. AUC of combined studies was significantly higher than for a single study (P Shear-wave elastography showed a good diagnostic performance. Adding SWE features to BI-RADS improved the diagnostic performance and may be helpful to stratify category 4 lesions. • Quantitative and qualitative shear-wave elastography provides further diagnostic information during breast ultrasound. • The elasticity ratio (E ratio ) showed the best diagnostic performance in SWE. • E ratio and four-colour overlay pattern significantly differed between benign and malignant lesions. • SWE features allowed further stratification of BI-RADS category 4 lesions.

  1. Can rapid integrated polymerase chain reaction-based diagnostics for gastrointestinal pathogens improve routine hospital infection control practice? A diagnostic study.

    Science.gov (United States)

    Pankhurst, Louise; Macfarlane-Smith, Louissa; Buchanan, James; Anson, Luke; Davies, Kerrie; O'Connor, Lily; Ashwin, Helen; Pike, Graham; Dingle, Kate E; Peto, Timothy Ea; Wordsworth, Sarah; Walker, A Sarah; Wilcox, Mark H; Crook, Derrick W

    2014-08-01

    Code assay, sensitivities for each organism compared with standard microbiological testing ranged from 43% to 94% and specificities from 95% to 98%, with particularly poor performance for S. enterica. Relatively large numbers of unexpected positives not confirmed with quantitative PCR were also observed, particularly for S. enterica, Giardia lamblia and Cryptosporidium spp. As the results indicated that S. enterica detection might provide generic challenges to other multiplex assays for gastrointestinal pathogens, the Luminex xTag(®) gastrointestinal assay was also run blinded on the same extracts (937/948 remaining) and on re-extracted samples (839/948 with sufficient material). For Campylobacter spp., C. difficile and norovirus, high sensitivities (> 92%) and specificities (> 96%) were observed. For S. enterica, on the original MassCode/Oxford extracts, Luminex sensitivity compared with standard microbiological testing was 84% [95% confidence interval (CI) 73% to 93%], but this dropped to 46% on a fresh extract, very similar to MassCode, with a corresponding increase in specificity from 92% to 99%. Overall agreement on the per-sample diagnosis compared with combined microbiology plus PCR for the main four/all pathogens was 85.6%/64.7%, 87.0%/82.9% and 89.8%/86.8% for the MassCode assay, Luminex assay/MassCode extract and Luminex assay/fresh extract, respectively. Luminex assay results from fresh extracts implied that 5% of samples did not represent infectious diarrhoea, even though enteropathogens were genuinely present. Managing infectious diarrhoea was a significant burden for infection control teams (taking 21% of their time) and better diagnostics were identified as having major potential benefits for patients. Overall, the Luminex xTag gastrointestinal panel showed similar or superior sensitivity and specificity to the MassCode assay. However, on fresh extracts, this test had low sensitivity to detect a key enteric pathogen, S. enterica; making it an unrealistic

  2. From molecular imaging to systems diagnostics: Time for another paradigm shift?

    Energy Technology Data Exchange (ETDEWEB)

    Li, King C.P. [Department of Radiology, Methodist Hospital, Weill Cornell Medical College, 6565 Fannin Street, D280 Houston, TX 77030 (United States)], E-mail: kli@tmhs.org

    2009-05-15

    The term 'Molecular Imaging' has hit the consciousness of radiologists only in the past decade although many of the concepts that molecular imaging encompasses has been practiced in biomedical imaging, especially in nuclear medicine, for many decades. Many new imaging techniques have allowed us to interrogate biologic events at the cellular and molecular level in vivo in four dimensions but the challenge now is to translate these techniques into clinical practice in a way that will enable us to revolutionize healthcare delivery. The purpose of this article is to introduce the term 'Systems Diagnostics' and examine how radiologists can become translators of disparate sources of information into medical decisions and therapeutic actions.

  3. A discontinous Galerkin finite element method with an efficient time integration scheme for accurate simulations

    KAUST Repository

    Liu, Meilin

    2011-07-01

    A discontinuous Galerkin finite element method (DG-FEM) with a highly-accurate time integration scheme is presented. The scheme achieves its high accuracy using numerically constructed predictor-corrector integration coefficients. Numerical results show that this new time integration scheme uses considerably larger time steps than the fourth-order Runge-Kutta method when combined with a DG-FEM using higher-order spatial discretization/basis functions for high accuracy. © 2011 IEEE.

  4. Photonic integrated circuit as a picosecond pulse timing discriminator.

    Science.gov (United States)

    Lowery, Arthur James; Zhuang, Leimeng

    2016-04-18

    We report the first experimental demonstration of a compact on-chip optical pulse timing discriminator that is able to provide an output voltage proportional to the relative timing of two 60-ps input pulses on separate paths. The output voltage is intrinsically low-pass-filtered, so the discriminator forms an interface between high-speed optics and low-speed electronics. Potential applications include timing synchronization of multiple pulse trains as a precursor for optical time-division multiplexing, and compact rangefinders with millimeter dimensions.

  5. Time efficiency and diagnostic accuracy of new automated myocardial perfusion analysis software in 320-row CT cardiac imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rief, Matthias; Stenzei, Fabian; Kranz, Anisha; Schlattmann, Peter; Dewey, Marc [Dept. of Radiology, Charite - Universiteitsmedizin Berlin, Berlin (Greece)

    2013-01-15

    We aimed to evaluate the time efficiency and diagnostic accuracy of automated myocardial computed tomography perfusion (CTP) image analysis software. 320-row CTP was performed in 30 patients, and analyses were conducted independently by three different blinded readers by the use of two recent software releases (version 4.6 and novel version 4.71GR001, Toshiba, Tokyo, Japan). Analysis times were compared, and automated epi- and endocardial contour detection was subjectively rated in five categories (excellent, good, fair, poor and very poor). As semi-quantitative perfusion parameters, myocardial attenuation and transmural perfusion ratio (TPR) were calculated for each myocardial segment and agreement was tested by using the intraclass correlation coefficient (ICC). Conventional coronary angiography served as reference standard. The analysis time was significantly reduced with the novel automated software version as compared with the former release (Reader 1: 43:08 ± 11:39 min vs. 09:47 ± 04:51 min, Reader 2: 42:07 ± 06:44 min vs. 09:42 ± 02:50 min and Reader 3: 21:38 ± 3:44 min vs. 07:34 ± 02:12 min; p < 0.001 for all). Epi- and endocardial contour detection for the novel software was rated to be significantly better (p < 0.001) than with the former software. ICCs demonstrated strong agreement (≥ 0.75) for myocardial attenuation in 93% and for TPR in 82%. Diagnostic accuracy for the two software versions was not significantly different (p 0.169) as compared with conventional coronary angiography. The novel automated CTP analysis software offers enhanced time efficiency with an improvement by a factor of about four, while maintaining diagnostic accuracy.

  6. Diode pumped solid state kilohertz disk laser system for time-resolved combustion diagnostics under microgravity at the drop tower Bremen

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Volker; Paa, Wolfgang; Triebel, Wolfgang [Institute of Photonic Technology, Laser Diagnostics, Albert-Einstein-Str. 9, 07745 Jena (Germany); Eigenbrod, Christian; Klinkov, Konstantin [Center of Applied Space Technology and Microgravity, University Bremen, Am Fallturm, 28359 Bremen (Germany); Larionov, Mikhail; Giesen, Adolf; Stolzenburg, Christian [Institut für Strahlwerkzeuge (IFSW), Pfaffenwaldring 43, 70569 Stuttgart (Germany)

    2014-03-15

    We describe a specially designed diode pumped solid state laser system based on the disk laser architecture for combustion diagnostics under microgravity (μg) conditions at the drop tower in Bremen. The two-stage oscillator-amplifier-system provides an excellent beam profile (TEM{sub 00}) at narrowband operation (Δλ < 1 pm) and is tunable from 1018 nm to 1052 nm. The laser repetition rate of up to 4 kHz at pulse durations of 10 ns enables the tracking of processes on a millisecond time scale. Depending on the specific issue it is possible to convert the output radiation up to the fourth harmonic around 257 nm. The very compact laser system is integrated in a slightly modified drop capsule and withstands decelerations of up to 50 g (>11 ms). At first the concept of the two-stage disk laser is briefly explained, followed by a detailed description of the disk laser adaption to the drop tower requirements with special focus on the intended use under μg conditions. In order to demonstrate the capabilities of the capsule laser as a tool for μg combustion diagnostics, we finally present an investigation of the precursor-reactions before the droplet ignition using 2D imaging of the Laser Induced Fluorescence of formaldehyde.

  7. Male bladder outlet obstruction: Time to re-evaluate the definition and reconsider our diagnostic pathway? ICI-RS 2015.

    Science.gov (United States)

    Rademakers, Kevin; Drake, Marcus J; Gammie, Andrew; Djurhuus, Jens C; Rosier, Peter F W M; Abrams, Paul; Harding, Christopher

    2017-04-01

    The diagnosis of bladder outlet obstruction (BOO) in the male is dependent on measurements of pressure and flow made during urodynamic studies. The procedure of urodynamics and the indices used to delineate BOO are well standardized largely as a result of the work of the International Continence Society. The clinical utility of the diagnosis of BOO is however, less well defined and there are several shortcomings and gaps in the currently available medical literature. Consequently the International Consultation on Incontinence Research Society (ICI-RS) held a think tank session in 2015 entitled "Male bladder outlet obstruction: Time to re-evaluate the definition and reconsider our diagnostic pathway?" This manuscript details the discussions that took place within that think tank setting out the pros and cons of the current definition of BOO and exploring alternative clinical tests (alone or in combination) which may be useful in the future investigation of male patients with lower urinary tract symptoms. The think tank panel concluded that pressure-flow studies remain the diagnostic gold-standard for BOO although there is still a lack of high quality evidence. Newer, less invasive, investigations have shown promise in terms of diagnostic accuracy for BOO but similar criticisms can be levelled against these tests. Therefore, the think tank suggests further research with regard to these alternative indicators to determine their clinical utility. © 2017 Wiley Periodicals, Inc.

  8. Explicit solution of Calderon preconditioned time domain integral equations

    KAUST Repository

    Ulku, Huseyin Arda; Bagci, Hakan; Michielssen, Eric

    2013-01-01

    operators and a PE(CE)m type linear multistep to march on in time. Unlike its implicit counterpart, the proposed explicit solver requires the solution of an MOT system with a Gram matrix that is sparse and well-conditioned independent of the time step size

  9. Kwong-Wong-type integral equation on time scales

    Directory of Open Access Journals (Sweden)

    Baoguo Jia

    2011-09-01

    Full Text Available Consider the second-order nonlinear dynamic equation $$ [r(tx^Delta(ho(t]^Delta+p(tf(x(t=0, $$ where $p(t$ is the backward jump operator. We obtain a Kwong-Wong-type integral equation, that is: If $x(t$ is a nonoscillatory solution of the above equation on $[T_0,infty$, then the integral equation $$ frac{r^sigma(tx^Delta(t}{f(x^sigma(t} =P^sigma(t+int^infty_{sigma(t}frac{r^sigma(s [int^1_0f'(x_h(sdh][x^Delta(s]^2}{f(x(s f(x^sigma(s}Delta s $$ is satisfied for $tgeq T_0$, where $P^sigma(t=int^infty_{sigma(t}p(sDelta s$, and $x_h(s=x(s+hmu(sx^Delta(s$. As an application, we show that the superlinear dynamic equation $$ [r(tx^{Delta}(ho(t]^Delta+p(tf(x(t=0, $$ is oscillatory, under certain conditions.

  10. Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis.

    Science.gov (United States)

    HaiFeng, Liu; YongSheng, Xu; YangQin, Xun; Yu, Dou; ShuaiWen, Wang; XingRu, Lu; JunQiang, Lei

    2017-11-01

    This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value. In addition, heterogeneity and subgroup analysis were carried out. In total, 18 studies comprising 3463 patients were selected. The results of 3D-TOF-MRA for diagnosing IA were SEN 0.89 (95% CI 0.82-0.94), SPE 0.94 (0.86-0.97), PLR 13.79 (5.92-32.12), NLR 0.11 (0.07-0.19), DOR 121.90 (38.81-382.94), and AUC 0.96 (0.94-0.98), respectively. In the subgroup analysis, studies without subarachnoid hemorrhage (SAH) tend to perform statistical significantly better (P 3D-TOF-MRA had better SEN in aneurysms > 3 mm than the aneurysms ≤ 3 mm in diameter: 0.89 (0.87-0.92) vs. 0.78 (0.71-0.84) with P 3D-TOF-MRA has an excellent diagnostic performance for the overall assessment of IA and may serve as an alternative for further patient management with IA.

  11. Diagnostic value of real-time tissue elastography for liver fibrosis in patients with chronic hepatitis B

    Directory of Open Access Journals (Sweden)

    ZHANG Guosheng

    2014-07-01

    Full Text Available ObjectiveTo investigate the diagnostic value of real-time tissue elastography (RTE in evaluating liver fibrosis in patients with chronic hepatitis B (CHB. MethodsEighty-six patients with CHB, who visited Beijing Tiantan Hospital and Beijing You′an Hospital from March to August, 2013, were grouped according to the pathological stages of liver fibrosis. They were examined by RTE, biochemical tests, and liver biopsy. Then, liver fibrosis index (LFI and aspartate aminotransferase-to-platelet ratio index (APRI were calculated. Comparison between groups was made by one-way analysis of variance, followed by LSD t-test for multiple comparisons. The correlation between LFI and pathological stage of liver fibrosis was analyzed by Spearman correlation test. The sensitivity and specificity of LFI for the diagnosis of liver fibrosis were calculated. Regarding S≥2 (significant liver fibrosis and S≥4 (early liver cirrhosis as the positive standards, the receiver operating characteristic (ROC curve was drawn and compared with APRI. ResultsLFI differed significantly across the groups (P=0.000, except the comparison between S0 and S1 (P=0.298. LFI was significantly correlated with pathological stage (r=0.831, P<0.001. The areas under the ROC curve of LFI in diagnosing significant liver fibrosis and early liver cirrhosis were 0873 (P<0.001 and 0.923 (P=0002, respectively; the diagnostic thresholds were 2.74 and 3.61, respectively; the sensitivity and specificity were 0.766/0.872 and 0.833/0.878, respectively. LFI was significantly superior to APRI. ConclusionRTE has high diagnostic values for significant liver fibrosis and early liver cirrhosis and is an important noninvasive diagnostic method for liver fibrosis in patients with CHB.

  12. Evaluation of time integration methods for transient response analysis of nonlinear structures

    International Nuclear Information System (INIS)

    Park, K.C.

    1975-01-01

    Recent developments in the evaluation of direct time integration methods for the transient response analysis of nonlinear structures are presented. These developments, which are based on local stability considerations of an integrator, show that the interaction between temporal step size and nonlinearities of structural systems has a pronounced effect on both accuracy and stability of a given time integration method. The resulting evaluation technique is applied to a model nonlinear problem, in order to: 1) demonstrate that it eliminates the present costly process of evaluating time integrator for nonlinear structural systems via extensive numerical experiments; 2) identify the desirable characteristics of time integration methods for nonlinear structural problems; 3) develop improved stiffly-stable methods for application to nonlinear structures. Extension of the methodology for examination of the interaction between a time integrator and the approximate treatment of nonlinearities (such as due to pseudo-force or incremental solution procedures) is also discussed. (Auth.)

  13. Floral pathway integrator gene expression mediates gradual transmission of environmental and endogenous cues to flowering time.

    Science.gov (United States)

    van Dijk, Aalt D J; Molenaar, Jaap

    2017-01-01

    The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues. These signals integrate into a network of floral pathway integrator genes. At a quantitative level, it is currently unclear how the impact of genetic variation in signaling pathways on flowering time is mediated by floral pathway integrator genes. Here, using datasets available from literature, we connect Arabidopsis thaliana flowering time in genetic backgrounds varying in upstream signalling components with the expression levels of floral pathway integrator genes in these genetic backgrounds. Our modelling results indicate that flowering time depends in a quite linear way on expression levels of floral pathway integrator genes. This gradual, proportional response of flowering time to upstream changes enables a gradual adaptation to changing environmental factors such as temperature and light.

  14. Floral pathway integrator gene expression mediates gradual transmission of environmental and endogenous cues to flowering time

    Directory of Open Access Journals (Sweden)

    Aalt D.J. van Dijk

    2017-04-01

    Full Text Available The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues. These signals integrate into a network of floral pathway integrator genes. At a quantitative level, it is currently unclear how the impact of genetic variation in signaling pathways on flowering time is mediated by floral pathway integrator genes. Here, using datasets available from literature, we connect Arabidopsis thaliana flowering time in genetic backgrounds varying in upstream signalling components with the expression levels of floral pathway integrator genes in these genetic backgrounds. Our modelling results indicate that flowering time depends in a quite linear way on expression levels of floral pathway integrator genes. This gradual, proportional response of flowering time to upstream changes enables a gradual adaptation to changing environmental factors such as temperature and light.

  15. Numerical Time Integration Methods for a Point Absorber Wave Energy Converter

    DEFF Research Database (Denmark)

    Zurkinden, Andrew Stephen; Kramer, Morten

    2012-01-01

    on a discretization of the convolution integral. The calculation of the convolution integral is performed at each time step regardless of the chosen numerical scheme. In the second model the convolution integral is replaced by a system of linear ordinary differential equations. The formulation of the state...

  16. The imaginary-time path integral and non-time-reversal-invariant saddle points of the Euclidean action

    International Nuclear Information System (INIS)

    Dasgupta, I.

    1998-01-01

    We discuss new bounce-like (but non-time-reversal-invariant) solutions to Euclidean equations of motion, which we dub boomerons. In the Euclidean path integral approach to quantum theories, boomerons make an imaginary contribution to the vacuum energy. The fake vacuum instability can be removed by cancelling boomeron contributions against contributions from time reversed boomerons (anti-boomerons). The cancellation rests on a sign choice whose significance is not completely understood in the path integral method. (orig.)

  17. Methods Developed by the Tools for Engine Diagnostics Task to Monitor and Predict Rotor Damage in Real Time

    Science.gov (United States)

    Baaklini, George Y.; Smith, Kevin; Raulerson, David; Gyekenyesi, Andrew L.; Sawicki, Jerzy T.; Brasche, Lisa

    2003-01-01

    Tools for Engine Diagnostics is a major task in the Propulsion System Health Management area of the Single Aircraft Accident Prevention project under NASA s Aviation Safety Program. The major goal of the Aviation Safety Program is to reduce fatal aircraft accidents by 80 percent within 10 years and by 90 percent within 25 years. The goal of the Propulsion System Health Management area is to eliminate propulsion system malfunctions as a primary or contributing factor to the cause of aircraft accidents. The purpose of Tools for Engine Diagnostics, a 2-yr-old task, is to establish and improve tools for engine diagnostics and prognostics that measure the deformation and damage of rotating engine components at the ground level and that perform intermittent or continuous monitoring on the engine wing. In this work, nondestructive-evaluation- (NDE-) based technology is combined with model-dependent disk spin experimental simulation systems, like finite element modeling (FEM) and modal norms, to monitor and predict rotor damage in real time. Fracture mechanics time-dependent fatigue crack growth and damage-mechanics-based life estimation are being developed, and their potential use investigated. In addition, wireless eddy current and advanced acoustics are being developed for on-wing and just-in-time NDE engine inspection to provide deeper access and higher sensitivity to extend on-wing capabilities and improve inspection readiness. In the long run, these methods could establish a base for prognostic sensing while an engine is running, without any overt actions, like inspections. This damage-detection strategy includes experimentally acquired vibration-, eddy-current- and capacitance-based displacement measurements and analytically computed FEM-, modal norms-, and conventional rotordynamics-based models of well-defined damages and critical mass imbalances in rotating disks and rotors.

  18. A novel particle time of flight diagnostic for measurements of shock- and compression-bang times in D3He and DT implosions at the NIF.

    Science.gov (United States)

    Rinderknecht, H G; Johnson, M Gatu; Zylstra, A B; Sinenian, N; Rosenberg, M J; Frenje, J A; Waugh, C J; Li, C K; Sèguin, F H; Petrasso, R D; Rygg, J R; Kimbrough, J R; MacPhee, A; Collins, G W; Hicks, D; Mackinnon, A; Bell, P; Bionta, R; Clancy, T; Zacharias, R; Döppner, T; Park, H S; LePape, S; Landen, O; Meezan, N; Moses, E I; Glebov, V U; Stoeckl, C; Sangster, T C; Olson, R; Kline, J; Kilkenny, J

    2012-10-01

    The particle-time-of-flight (pTOF) diagnostic, fielded alongside a wedge range-filter (WRF) proton spectrometer, will provide an absolute timing for the shock-burn weighted ρR measurements that will validate the modeling of implosion dynamics at the National Ignition Facility (NIF). In the first phase of the project, pTOF has recorded accurate bang times in cryogenic DT, DT exploding pusher, and D(3)He implosions using DD or DT neutrons with an accuracy better than ±70 ps. In the second phase of the project, a deflecting magnet will be incorporated into the pTOF design for simultaneous measurements of shock- and compression-bang times in D(3)He-filled surrogate implosions using D(3)He protons and DD-neutrons, respectively.

  19. Integrating Security in Real-Time Embedded Systems

    Science.gov (United States)

    2017-04-26

    Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arl ington, VA 22202-4302. Respondents should be aware that... operate without impacting the tinting and safety constraints of the control logic. Besides, the embedded nature of these systems limits the...only during slack times when no other real-time tasks are rwming. We propose to measure the security of the system by means of the achievable periodic

  20. Multiple time step integrators in ab initio molecular dynamics

    International Nuclear Information System (INIS)

    Luehr, Nathan; Martínez, Todd J.; Markland, Thomas E.

    2014-01-01

    Multiple time-scale algorithms exploit the natural separation of time-scales in chemical systems to greatly accelerate the efficiency of molecular dynamics simulations. Although the utility of these methods in systems where the interactions are described by empirical potentials is now well established, their application to ab initio molecular dynamics calculations has been limited by difficulties associated with splitting the ab initio potential into fast and slowly varying components. Here we present two schemes that enable efficient time-scale separation in ab initio calculations: one based on fragment decomposition and the other on range separation of the Coulomb operator in the electronic Hamiltonian. We demonstrate for both water clusters and a solvated hydroxide ion that multiple time-scale molecular dynamics allows for outer time steps of 2.5 fs, which are as large as those obtained when such schemes are applied to empirical potentials, while still allowing for bonds to be broken and reformed throughout the dynamics. This permits computational speedups of up to 4.4x, compared to standard Born-Oppenheimer ab initio molecular dynamics with a 0.5 fs time step, while maintaining the same energy conservation and accuracy

  1. On-line integration of computer controlled diagnostic devices and medical information systems in undergraduate medical physics education for physicians.

    Science.gov (United States)

    Hanus, Josef; Nosek, Tomas; Zahora, Jiri; Bezrouk, Ales; Masin, Vladimir

    2013-01-01

    We designed and evaluated an innovative computer-aided-learning environment based on the on-line integration of computer controlled medical diagnostic devices and a medical information system for use in the preclinical medical physics education of medical students. Our learning system simulates the actual clinical environment in a hospital or primary care unit. It uses a commercial medical information system for on-line storage and processing of clinical type data acquired during physics laboratory classes. Every student adopts two roles, the role of 'patient' and the role of 'physician'. As a 'physician' the student operates the medical devices to clinically assess 'patient' colleagues and records all results in an electronic 'patient' record. We also introduced an innovative approach to the use of supportive education materials, based on the methods of adaptive e-learning. A survey of student feedback is included and statistically evaluated. The results from the student feedback confirm the positive response of the latter to this novel implementation of medical physics and informatics in preclinical education. This approach not only significantly improves learning of medical physics and informatics skills but has the added advantage that it facilitates students' transition from preclinical to clinical subjects. Copyright © 2011 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  2. Neoplastic pleural effusion and intrathoracic metastasis of a scapular osteosarcoma in a dog: a multidisciplinary integrated diagnostic approach.

    Science.gov (United States)

    Mesquita, Luis; Mortier, Jeremy; Ressel, Lorenzo; Finotello, Riccardo; Silvestrini, Paolo; Piviani, Martina

    2017-06-01

    A 10-year-old, female spayed mixed-breed or cross-bred dog was referred to the Small Animal Teaching Hospital of the University of Liverpool due to tachypnea, dyspnea, and pleural effusion not responding to diuretics and antibiotics. The chest was drained and cytology of the pleural fluid was consistent with a modified transudate with presence of atypical cells initially attributed to mesothelial hyperplasia and dysplasia. Computed tomography detected, in addition to the bilateral pleural effusion, diffuse pleural thickening, multiple pleural and pulmonary nodules, and a mineralized and lytic mass in the left scapula. Imaging findings were suggestive of a primary bone tumor with intrathoracic metastasis. Cytology of the left scapular and pleural masses revealed a malignant neoplasm highly suggestive of osteosarcoma. The diagnosis was confirmed by demonstration of a positive cytochemical reaction for alkaline phosphatase on prestained cytology slides. This finding prompted review of the initial interpretation of the pleural effusion cytology. The presence of neoplastic osteoblasts in the thoracic fluid was identified by a combination of cytochemistry, cell pellet immunohistochemistry, and transmission electron microscopy findings. In this report, a multidisciplinary integrated diagnostic approach was used to diagnose and confirm a neoplastic pleural effusion due to osteosarcoma metastasis in a dog. © 2017 American Society for Veterinary Clinical Pathology.

  3. Rapid lung MRI in children with pulmonary infections: Time to change our diagnostic algorithms.

    Science.gov (United States)

    Sodhi, Kushaljit Singh; Khandelwal, Niranjan; Saxena, Akshay Kumar; Singh, Meenu; Agarwal, Ritesh; Bhatia, Anmol; Lee, Edward Y

    2016-05-01

    To determine the diagnostic utility of a new rapid MRI protocol, as compared with computed tomography (CT) for the detection of various pulmonary and mediastinal abnormalities in children with suspected pulmonary infections. Seventy-five children (age range of 5 to 15 years) with clinically suspected pulmonary infections were enrolled in this prospective study, which was approved by the institutional ethics committee. All patients underwent thoracic MRI (1.5T) and CT (64 detector) scan within 48 h of each other. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI were evaluated with CT as a standard of reference. Inter-observer agreement was measured with the kappa coefficient. MRI with a new rapid MRI protocol demonstrated sensitivity, specificity, PPV, and NPV of 100% for detecting pulmonary consolidation, nodules (>3 mm), cyst/cavity, hyperinflation, pleural effusion, and lymph nodes. The kappa-test showed almost perfect agreement between MRI and multidetector CT (MDCT) in detecting thoracic abnormalities (k = 0.9). No statistically significant difference was observed between MRI and MDCT for detecting thoracic abnormalities by the McNemar test (P = 0.125). Rapid lung MRI was found to be comparable to MDCT for detecting thoracic abnormalities in pediatric patients with clinically suspected pulmonary infections. It has a great potential as the first line cross-sectional imaging modality of choice in this patient population. However, further studies will be helpful for confirmation of our findings. © 2015 Wiley Periodicals, Inc.

  4. Time-resolved diagnostics of excimer laser-generated ablation plasmas used for pulsed laser deposition

    Energy Technology Data Exchange (ETDEWEB)

    Geohegan, D.B.

    1994-09-01

    Characteristics of laser plasmas used for pulsed laser deposition (PLD) of thin films are examined with four in situ diagnostic techniques: Optical emission spectroscopy, optical absorption spectroscopy, ion probe studies, and gated ICCD (intensified charge-coupled-device array) fast photography. These four techniques are complementary and permit simultaneous views of the transport of ions, excited states, ground state neutrals and ions, and hot particulates following KrF laser ablation of YBCO, BN, graphite and Si in vacuum and background gases. The implementation and advantages of the four techniques are first described in order to introduce the key features of laser plasmas for pulsed laser deposition. Aspects of the interaction of the ablation plume with background gases (i.e., thermalization, attenuation, shock formation) and the collision of the plasma plume with the substrate heater are then summarized. The techniques of fast ICCD photography and gated photon counting are then applied to investigate the temperature, velocity, and spatial distribution of hot particles generated during KrF ablation of YBCO, BN, Si and graphite. Finally, key features of fast imaging of the laser ablation of graphite into high pressure rare gases are presented in order to elucidate internal reflected shocks within the plume, redeposition of material on a surface, and formation of hot nanoparticles within the plume.

  5. Time-resolved diagnostics of excimer laser-generated ablation plasmas used for pulsed laser deposition

    International Nuclear Information System (INIS)

    Geohegan, D.B.

    1994-01-01

    Characteristics of laser plasmas used for pulsed laser deposition (PLD) of thin films are examined with four in situ diagnostic techniques: Optical emission spectroscopy, optical absorption spectroscopy, ion probe studies, and gated ICCD (intensified charge-coupled-device array) fast photography. These four techniques are complementary and permit simultaneous views of the transport of ions, excited states, ground state neutrals and ions, and hot particulates following KrF laser ablation of YBCO, BN, graphite and Si in vacuum and background gases. The implementation and advantages of the four techniques are first described in order to introduce the key features of laser plasmas for pulsed laser deposition. Aspects of the interaction of the ablation plume with background gases (i.e., thermalization, attenuation, shock formation) and the collision of the plasma plume with the substrate heater are then summarized. The techniques of fast ICCD photography and gated photon counting are then applied to investigate the temperature, velocity, and spatial distribution of hot particles generated during KrF ablation of YBCO, BN, Si and graphite. Finally, key features of fast imaging of the laser ablation of graphite into high pressure rare gases are presented in order to elucidate internal reflected shocks within the plume, redeposition of material on a surface, and formation of hot nanoparticles within the plume

  6. Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI.

    Science.gov (United States)

    Trend, Stephanie; Jones, Anderson P; Geldenhuys, Sian; Byrne, Scott N; Fabis-Pedrini, Marzena J; Nolan, David; Booth, David R; Carroll, William M; Lucas, Robyn M; Kermode, Allan G; Hart, Prue H

    2017-06-15

    It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS.

  7. Formulation of an explicit-multiple-time-step time integration method for use in a global primitive equation grid model

    Science.gov (United States)

    Chao, W. C.

    1982-01-01

    With appropriate modifications, a recently proposed explicit-multiple-time-step scheme (EMTSS) is incorporated into the UCLA model. In this scheme, the linearized terms in the governing equations that generate the gravity waves are split into different vertical modes. Each mode is integrated with an optimal time step, and at periodic intervals these modes are recombined. The other terms are integrated with a time step dictated by the CFL condition for low-frequency waves. This large time step requires a special modification of the advective terms in the polar region to maintain stability. Test runs for 72 h show that EMTSS is a stable, efficient and accurate scheme.

  8. Time, dynamics and chaos. Integrating Poincare's "non-integrable systems"

    Energy Technology Data Exchange (ETDEWEB)

    Prigogine, I.

    1990-01-01

    This report discusses the nature of time. The author attempts to resolve the conflict between the concept of time reversibility in classical and quantum mechanics with the macroscopic world's irreversibility of time. (LSP)

  9. Numerical integration of the Teukolsky equation in the time domain

    International Nuclear Information System (INIS)

    Pazos-Avalos, Enrique; Lousto, Carlos O.

    2005-01-01

    We present a fourth-order convergent (2+1)-dimensional, numerical formalism to solve the Teukolsky equation in the time domain. Our approach is first to rewrite the Teukolsky equation as a system of first-order differential equations. In this way we get a system that has the form of an advection equation. This is then used in combination with a series expansion of the solution in powers of time. To obtain a fourth-order scheme we kept terms up to fourth derivative in time and use the advectionlike system of differential equations to substitute the temporal derivatives by spatial derivatives. This scheme is applied to evolve gravitational perturbations in the Schwarzschild and Kerr backgrounds. Our numerical method proved to be stable and fourth-order convergent in r* and θ directions. The correct power-law tail, ∼1/t 2l+3 , for general initial data, and ∼1/t 2l+4 , for time-symmetric data, was found in our runs. We noted that it is crucial to resolve accurately the angular dependence of the mode at late times in order to obtain these values of the exponents in the power-law decay. In other cases, when the decay was too fast and round-off error was reached before a tail was developed, then the quasinormal modes frequencies provided a test to determine the validity of our code

  10. Development, Evaluation, and Integration of a Quantitative Reverse-Transcription Polymerase Chain Reaction Diagnostic Test for Ebola Virus on a Molecular Diagnostics Platform.

    Science.gov (United States)

    Cnops, Lieselotte; Van den Eede, Peter; Pettitt, James; Heyndrickx, Leo; De Smet, Birgit; Coppens, Sandra; Andries, Ilse; Pattery, Theresa; Van Hove, Luc; Meersseman, Geert; Van Den Herrewegen, Sari; Vergauwe, Nicolas; Thijs, Rein; Jahrling, Peter B; Nauwelaers, David; Ariën, Kevin K

    2016-10-15

     The 2013-2016 Ebola epidemic in West Africa resulted in accelerated development of rapid diagnostic tests for emergency outbreak preparedness. We describe the development and evaluation of the Idylla™ prototype Ebola virus test, a fully automated sample-to-result molecular diagnostic test for rapid detection of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).  The Idylla™ prototype Ebola virus test can simultaneously detect EBOV and SUDV in 200 µL of whole blood. The sample is directly added to a disposable cartridge containing all reagents for sample preparation, RNA extraction, and amplification by reverse-transcription polymerase chain reaction analysis. The performance was evaluated with a variety of sample types, including synthetic constructs and whole blood samples from healthy volunteers spiked with viral RNA, inactivated virus, and infectious virus.  The 95% limits of detection for EBOV and SUDV were 465 plaque-forming units (PFU)/mL (1010 copies/mL) and 324 PFU/mL (8204 copies/mL), respectively. In silico and in vitro analyses demonstrated 100% correct reactivity for EBOV and SUDV and no cross-reactivity with relevant pathogens. The diagnostic sensitivity was 97.4% (for EBOV) and 91.7% (for SUDV), the specificity was 100%, and the diagnostic accuracy was 95.9%.  The Idylla™ prototype Ebola virus test is a fast, safe, easy-to-use, and near-patient test that meets the performance criteria to detect EBOV in patients with suspected Ebola. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  11. An integration time adaptive control method for atmospheric composition detection of occultation

    Science.gov (United States)

    Ding, Lin; Hou, Shuai; Yu, Fei; Liu, Cheng; Li, Chao; Zhe, Lin

    2018-01-01

    When sun is used as the light source for atmospheric composition detection, it is necessary to image sun for accurate identification and stable tracking. In the course of 180 second of the occultation, the magnitude of sun light intensity through the atmosphere changes greatly. It is nearly 1100 times illumination change between the maximum atmospheric and the minimum atmospheric. And the process of light change is so severe that 2.9 times per second of light change can be reached. Therefore, it is difficult to control the integration time of sun image camera. In this paper, a novel adaptive integration time control method for occultation is presented. In this method, with the distribution of gray value in the image as the reference variable, and the concepts of speed integral PID control, the integration time adaptive control problem of high frequency imaging. The large dynamic range integration time automatic control in the occultation can be achieved.

  12. Diagnoses of Autism Spectrum Disorders in Germany: Time Trends in Administrative Prevalence and Diagnostic Stability

    Science.gov (United States)

    Bachmann, Christian J.; Gerste, Bettina; Hoffmann, Falk

    2018-01-01

    For Germany, no data on trends in autism spectrum disorder diagnoses are available. The primary aim of this study was to establish the time trends in the administrative prevalence of autism spectrum disorder diagnoses. The second aim was to assess the stability of autism spectrum disorder diagnoses over time. We analysed administrative outpatient…

  13. Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, HaiFeng; Xu, YongSheng [First Hospital of LanZhou University, Department of Radiology, Lanzhou, Gansu (China); First Clinical Medical College of LanZhou University, Lanzhou, Gansu (China); Xun, YangQin [Lanzhou University, Evidence-based Medicine Center, Lanzhou (China); Dou, Yu; Wang, ShuaiWen; Lu, XingRu; Lei, JunQiang [First Hospital of LanZhou University, Department of Radiology, Lanzhou, Gansu (China)

    2017-11-15

    This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value. In addition, heterogeneity and subgroup analysis were carried out. In total, 18 studies comprising 3463 patients were selected. The results of 3D-TOF-MRA for diagnosing IA were SEN 0.89 (95% CI 0.82-0.94), SPE 0.94 (0.86-0.97), PLR 13.79 (5.92-32.12), NLR 0.11 (0.07-0.19), DOR 121.90 (38.81-382.94), and AUC 0.96 (0.94-0.98), respectively. In the subgroup analysis, studies without subarachnoid hemorrhage (SAH) tend to perform statistical significantly better (P < 0.05) in detecting IAs than studies with SAH 0.99 (0.98-1.00) vs. 0.89 (0.86-0.91). The diagnostic value of studies with a two-image reconstruction method was higher than studies with only one image reconstruction method: 0.99 (0.98-1.00) vs. 0.91 (0.89-0.94) with P < 0.05. The 3D-TOF-MRA had better SEN in aneurysms > 3 mm than the aneurysms ≤ 3 mm in diameter: 0.89 (0.87-0.92) vs. 0.78 (0.71-0.84) with P < 0.05. This study demonstrated that 3D-TOF-MRA has an excellent diagnostic performance for the overall assessment of IA and may serve as an alternative for further patient management with IA. (orig.)

  14. Real-Time Integrated Re-scheduling for Tramway Operations

    NARCIS (Netherlands)

    Cheung, Kam-Fung; Kuo, Yong-Hong; Lai, S.W.; Leung, Janny M.Y.

    2018-01-01

    Our work aims to develop practical solution approaches for real-time dispatch of crews and vehicles for disruption management. The practical motivation for our research arose from the operations of a public tramway system in Hong Kong. The tram system shares the road with other vehicular traffic in

  15. Integrated capacity and inventory management with capacity acquisition lead times

    NARCIS (Netherlands)

    Mincsovics, G.Z.; Tan, T.; Alp, O.

    2009-01-01

    We model a make-to-stock production system that utilizes permanent and contingent capacity to meet non-stationary stochastic demand, where a constant lead time is associated with the acquisition of contingent capacity. We determine the structure of the optimal solution concerning both the

  16. The Feynman integral for time-dependent anharmonic oscillators

    International Nuclear Information System (INIS)

    Grothaus, M.; Khandekar, D.C.; da Silva, J.L.; Streit, L.

    1997-01-01

    We review some basic notions and results of white noise analysis that are used in the construction of the Feynman integrand as a generalized white noise functional. We show that the Feynman integrand for the time-dependent harmonic oscillator in an external potential is a Hida distribution. copyright 1997 American Institute of Physics

  17. Representing real time semantics for distributed application integration

    NARCIS (Netherlands)

    Poon, P.M.S.; Dillon, T.S.; Chang, E.; Feng, L.

    Traditional real time system design and development are driven by technological requirements. With the ever growing complexity of requirements and the advances in software design, the alignment of focus has gradually been shifted to the perspective of business and industrial needs. This paper

  18. Integration of the time-dependent heat equation in the fuel rod performance program IAMBUS

    International Nuclear Information System (INIS)

    West, G.

    1982-01-01

    An iterative numerical method for integration of the time-dependent heat equation is described. No presuppositions are made for the dependency of the thermal conductivity and heat capacity on space, time and temperature. (orig.) [de

  19. Rapid and sensitive detection of Yersinia pestis using amplification of plague diagnostic bacteriophages monitored by real-time PCR.

    Directory of Open Access Journals (Sweden)

    Kirill V Sergueev

    Full Text Available BACKGROUND: Yersinia pestis, the agent of plague, has caused many millions of human deaths and still poses a serious threat to global public health. Timely and reliable detection of such a dangerous pathogen is of critical importance. Lysis by specific bacteriophages remains an essential method of Y. pestis detection and plague diagnostics. METHODOLOGY/PRINCIPAL FINDINGS: The objective of this work was to develop an alternative to conventional phage lysis tests--a rapid and highly sensitive method of indirect detection of live Y. pestis cells based on quantitative real-time PCR (qPCR monitoring of amplification of reporter Y. pestis-specific bacteriophages. Plague diagnostic phages phiA1122 and L-413C were shown to be highly effective diagnostic tools for the detection and identification of Y. pestis by using qPCR with primers specific for phage DNA. The template DNA extraction step that usually precedes qPCR was omitted. phiA1122-specific qPCR enabled the detection of an initial bacterial concentration of 10(3 CFU/ml (equivalent to as few as one Y. pestis cell per 1-microl sample in four hours. L-413C-mediated detection of Y. pestis was less sensitive (up to 100 bacteria per sample but more specific, and thus we propose parallel qPCR for the two phages as a rapid and reliable method of Y. pestis identification. Importantly, phiA1122 propagated in simulated clinical blood specimens containing EDTA and its titer rise was detected by both a standard plating test and qPCR. CONCLUSIONS/SIGNIFICANCE: Thus, we developed a novel assay for detection and identification of Y. pestis using amplification of specific phages monitored by qPCR. The method is simple, rapid, highly sensitive, and specific and allows the detection of only live bacteria.

  20. An efficient explicit marching on in time solver for magnetic field volume integral equation

    KAUST Repository

    Sayed, Sadeed Bin; Ulku, H. Arda; Bagci, Hakan

    2015-01-01

    An efficient explicit marching on in time (MOT) scheme for solving the magnetic field volume integral equation is proposed. The MOT system is cast in the form of an ordinary differential equation and is integrated in time using a PE(CE)m multistep

  1. Design and implementation of real-time diagnostic expert system in nuclear power plant

    International Nuclear Information System (INIS)

    Zhang Yan; Zhou Zhiwei; Dong Xiuchen

    2006-01-01

    In order to decrease the probability of malfunctions in nuclear power plant, a real-time expert system to be applied to malfunction diagnosis was designed. Based on the expert system theory the system converts the expert knowledge for diagnosing failures into the rules stored in database, and it can display real-time information of the abnormal symptoms, perform real-time diagnosis of malfunctions and suggest the operation actions related to malfunctions, etc. The results indicate that several typical malfunctions in nuclear power plant are diagnosed automatically and the corresponding operation schedules are given out by present expert system. (authors)

  2. High resolution time integration for SN radiation transport

    International Nuclear Information System (INIS)

    Thoreson, Greg; McClarren, Ryan G.; Chang, Jae H.

    2009-01-01

    First-order, second-order, and high resolution time discretization schemes are implemented and studied for the discrete ordinates (S N ) equations. The high resolution method employs a rate of convergence better than first-order, but also suppresses artificial oscillations introduced by second-order schemes in hyperbolic partial differential equations. The high resolution method achieves these properties by nonlinearly adapting the time stencil to use a first-order method in regions where oscillations could be created. We employ a quasi-linear solution scheme to solve the nonlinear equations that arise from the high resolution method. All three methods were compared for accuracy and convergence rates. For non-absorbing problems, both second-order and high resolution converged to the same solution as the first-order with better convergence rates. High resolution is more accurate than first-order and matches or exceeds the second-order method

  3. An integral time series on simulated labeling using fractal structure

    International Nuclear Information System (INIS)

    Djainal, D.D.

    1997-01-01

    This research deals with the detection of time series of vertical two-phase flow, in attempt to developed an objective indicator of time series flow patterns. One of new method is fractal analysis which can complement conventional methods in the description of highly irregular fluctuations. in the present work, fractal analysis applied to analyze simulated boiling coolant signal. this simulated signals built by sum random elements in small subchannels of the coolant channel. Two modes are defined and both modes are characterized by their void fractions. in the case of unimodal-PDF signals, the difference between these modes is relative small. on other hand, bimodal-PDF signals have relative large range. in this research, fractal dimension can indicate the characters of that signals simulation

  4. The role of residence time in diagnostic models of global carbon storage capacity: model decomposition based on a traceable scheme.

    Science.gov (United States)

    Yizhao, Chen; Jianyang, Xia; Zhengguo, Sun; Jianlong, Li; Yiqi, Luo; Chengcheng, Gang; Zhaoqi, Wang

    2015-11-06

    As a key factor that determines carbon storage capacity, residence time (τE) is not well constrained in terrestrial biosphere models. This factor is recognized as an important source of model uncertainty. In this study, to understand how τE influences terrestrial carbon storage prediction in diagnostic models, we introduced a model decomposition scheme in the Boreal Ecosystem Productivity Simulator (BEPS) and then compared it with a prognostic model. The result showed that τE ranged from 32.7 to 158.2 years. The baseline residence time (τ'E) was stable for each biome, ranging from 12 to 53.7 years for forest biomes and 4.2 to 5.3 years for non-forest biomes. The spatiotemporal variations in τE were mainly determined by the environmental scalar (ξ). By comparing models, we found that the BEPS uses a more detailed pool construction but rougher parameterization for carbon allocation and decomposition. With respect to ξ comparison, the global difference in the temperature scalar (ξt) averaged 0.045, whereas the moisture scalar (ξw) had a much larger variation, with an average of 0.312. We propose that further evaluations and improvements in τ'E and ξw predictions are essential to reduce the uncertainties in predicting carbon storage by the BEPS and similar diagnostic models.

  5. A real-time digital control, data acquisition and analysis system for the DIII-D multipulse Thomson scattering diagnostic

    International Nuclear Information System (INIS)

    Greenfield, C.M.; Campbell, G.L.; Carlstrom, T.N.; DeBoo, J.C.; Hsieh, C.-L.; Snider, R.T.; Trost, P.K.

    1990-10-01

    A VME-based real-time computer systems for laser control, data acquisition and analysis for the DIII-D multipulse Thomson scattering diagnostic is described. The laser control task requires precise timing of up to 8 Nd:YAG lasers, each with an average firing rate of 20 Hz. A cpu module in real-time multiprocessing computer system will operate the lasers with evenly staggered laser pulses or in a ''burst mode'', where all available (fully charged) lasers can be fired at 50--100 μsec intervals upon receipt of an external event trigger signal. One of more cpu modules, along with a LeCroy FERA (Fast Encoding and Readout ADC) system, will perform real-time data acquisition and analysis. Partial electron temperature and density profiles will be available for plasma feedback control within 1 msec following each laser pulse. The VME-based computer system consists of 2 or more target processor modules (25 MHz Motorola 68030) running the VMEexec real-time operating system connected to a Unix based host system (also a 68030). All real-time software is fully interrupt driven to maximize system efficiency. Operator interaction and (non real-time) data analysis takes place on a MicroVAX 3400 connected via DECnet. 17 refs., 1 fig

  6. Real-time digital control, data acquisition, and analysis system for the DIII-D multipulse Thomson scattering diagnostic

    International Nuclear Information System (INIS)

    Greenfield, C.M.; Campbell, G.L.; Carlstrom, T.N.; DeBoo, J.C.; Hsieh, C.; Snider, R.T.; Trost, P.K.

    1990-01-01

    A VME-based real-time computer system for laser control, data acquisition, and analysis for the DIII-D multipulse Thomson scattering diagnostic is described. The laser control task requires precise timing of up to eight Nd:YAG lasers, each with an average firing rate of 20 Hz. A cpu module in a real-time multiprocessing computer system will operate the lasers with evenly staggered laser pulses or in a ''burst mode,'' where all available (fully charged) lasers can be fired at 50--100 μs intervals upon receipt of an external event trigger signal. One or more cpu modules, along with a LeCroy FERA (fast encoding and readout ADC) system, will perform real-time data acquisition and analysis. Partial electron temperature and density profiles will be available for plasma feedback control within 1 ms following each laser pulse. The VME-based computer system consists of two or more target processor modules (25 MHz Motorola 68030) running the VMEexec real-time operating system connected to a Unix-based host system (also a 68030). All real-time software is fully interrupt driven to maximize system efficiency. Operator interaction and (non-real-time) data analysis takes place on a MicroVAX 3400 connected via DECnet

  7. On the initial condition problem of the time domain PMCHWT surface integral equation

    KAUST Repository

    Uysal, Ismail Enes

    2017-05-13

    Non-physical, linearly increasing and constant current components are induced in marching on-in-time solution of time domain surface integral equations when initial conditions on time derivatives of (unknown) equivalent currents are not enforced properly. This problem can be remedied by solving the time integral of the surface integral for auxiliary currents that are defined to be the time derivatives of the equivalent currents. Then the equivalent currents are obtained by numerically differentiating the auxiliary ones. In this work, this approach is applied to the marching on-in-time solution of the time domain Poggio-Miller-Chan-Harrington-Wu-Tsai surface integral equation enforced on dispersive/plasmonic scatterers. Accuracy of the proposed method is demonstrated by a numerical example.

  8. Analytical solutions for prediction of the ignition time of wood particles based on a time and space integral method

    NARCIS (Netherlands)

    Haseli, Y.; Oijen, van J.A.; Goey, de L.P.H.

    2012-01-01

    The main idea of this paper is to establish a simple approach for prediction of the ignition time of a wood particle assuming that the thermo-physical properties remain constant and ignition takes place at a characteristic ignition temperature. Using a time and space integral method, explicit

  9. Integrated systems for real time data acquisition and processing

    International Nuclear Information System (INIS)

    Oprea, I.; Oprea, M.

    1995-01-01

    The continuous measuring of all the nuclear and dosimetric parameters in a nuclear facility is essential for personnel and environment protection. Considering the vast amount of information and data required to keep an updated overview of a situation the need for an efficient acquisition processing and information system is evident. The paper analyses the special requirements as concerning the real time inter-process communication and proposes a modern concept based on the last trends existing in the field of computer technology and operating systems. (author)

  10. High resolution time integration for Sn radiation transport

    International Nuclear Information System (INIS)

    Thoreson, Greg; McClarren, Ryan G.; Chang, Jae H.

    2008-01-01

    First order, second order and high resolution time discretization schemes are implemented and studied for the S n equations. The high resolution method employs a rate of convergence better than first order, but also suppresses artificial oscillations introduced by second order schemes in hyperbolic differential equations. All three methods were compared for accuracy and convergence rates. For non-absorbing problems, both second order and high resolution converged to the same solution as the first order with better convergence rates. High resolution is more accurate than first order and matches or exceeds the second order method. (authors)

  11. MERRA 2D IAU Ocean Surface Diagnostic, Single Level, Time Avg 1-hr (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXOCN or tavg1_2d_ocn_Nx data product is the MERRA Data Assimilation System 2-Dimensional ocean surface single-level diagnostics that is time averaged...

  12. MERRA 3D IAU Diagnostic, Turbulence, Time average 3-hourly (1.25x1.25L42) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT3CPTRB or tavg3_3d_trb_Cp data product is the MERRA Data Assimilation System 3-Dimensional turbulence diagnostic that is time averaged on pressure levels at a...

  13. MERRA 3D IAU Diagnostic, Cloud Properties, Time average 3-hourly (1.25x1.25L42) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT3CPCLD or tavg3_3d_cld_Cp data product is the MERRA Data Assimilation System 3-Dimensional cloud diagnostic that is time averaged on pressure levels at a...

  14. MERRA 3D IAU Diagnostic, Moist Physics, Time average 3-hourly (1.25x1.25L42) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT3CPMST or tavg3_3d_mst_Cp data product is the MERRA Data Assimilation System 3-Dimensional moist process diagnostic that is time averaged on pressure levels...

  15. MERRA 3D IAU Diagnostic, Radiation, Time average 3-hourly (1.25x1.25L42) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT3CPRAD or tavg3_3d_rad_Cp data product is the MERRA Data Assimilation System 3-Dimensional radiation diagnostic that is time averaged on pressure levels at a...

  16. MERRA 2D IAU Diagnostic, Surface Fluxes, Time Average 1-hourly (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXFLX or tavg1_2d_flx_Nx data product is the MERRA Data Assimilation System 2-Dimensional surface turbulence flux diagnostic that is time averaged...

  17. MERRA 2D IAU Diagnostic, Single Level Meteorology, Time Average 1-hourly (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXSLV or tavg1_2d_slv_Nx data product is the MERRA Data Assimilation System 2-Dimensional atmospheric single-level diagnostics that is time averaged...

  18. Design of time-pulse coded optoelectronic neuronal elements for nonlinear transformation and integration

    Science.gov (United States)

    Krasilenko, Vladimir G.; Nikolsky, Alexander I.; Lazarev, Alexander A.; Lazareva, Maria V.

    2008-03-01

    In the paper the actuality of neurophysiologically motivated neuron arrays with flexibly programmable functions and operations with possibility to select required accuracy and type of nonlinear transformation and learning are shown. We consider neurons design and simulation results of multichannel spatio-time algebraic accumulation - integration of optical signals. Advantages for nonlinear transformation and summation - integration are shown. The offered circuits are simple and can have intellectual properties such as learning and adaptation. The integrator-neuron is based on CMOS current mirrors and comparators. The performance: consumable power - 100...500 μW, signal period- 0.1...1ms, input optical signals power - 0.2...20 μW time delays - less 1μs, the number of optical signals - 2...10, integration time - 10...100 of signal periods, accuracy or integration error - about 1%. Various modifications of the neuron-integrators with improved performance and for different applications are considered in the paper.

  19. Integrated active sensor system for real time vibration monitoring.

    Science.gov (United States)

    Liang, Qijie; Yan, Xiaoqin; Liao, Xinqin; Cao, Shiyao; Lu, Shengnan; Zheng, Xin; Zhang, Yue

    2015-11-05

    We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor and detected objects. The as-fabricated sensor matrix is capable of monitoring and mapping the vibration state of large amounts of units. The monitoring contents include: on-off state, vibration frequency and vibration amplitude of each unit. The active sensor system delivers a detection range of 0-60 Hz, high accuracy (relative error below 0.42%), long-term stability (10000 cycles). On the time dimension, the sensor can provide the vibration process memory by recording the outputs of the sensor system in an extend period of time. Besides, the developed sensor system can realize detection under contact mode and non-contact mode. Its high performance is not sensitive to the shape or the conductivity of the detected object. With these features, the active sensor system has great potential in automatic control, remote operation, surveillance and security systems.

  20. Multi-channel time-division integrator in HL-2A

    International Nuclear Information System (INIS)

    Yan Ji

    2008-01-01

    HL-2A is China's first Tokamak device with divertor configuration (magnetic confinement controlled nuclear fusion device). To find out the details of on-going fusion reaction at different times is of important significance in achieving controlled nuclear fusion. We developed a new type multi-channel time-division integrator for HL-2A. It has functions of automatic cutting off negative pulse of the input signals, optional integrating time division spacing 0.2-1 ms, TTL starting trigger signal, automatic regularly work 20 s, and integrating 10 channel at the same time. (authors)

  1. Predicting turnaround time reductions of the diagnostic track in the histopathology laboratory using mathematical modelling

    NARCIS (Netherlands)

    Leeftink, A G; Boucherie, R J; Hans, E W; Verdaasdonk, M A M; Vliegen, I M H; van Diest, P J

    BACKGROUND: Pathology departments face a growing volume of more and more complex testing in an era where healthcare costs tend to explode and short turnaround times (TATs) are expected. In contrast, the histopathology workforce tends to shrink, so histopathology employees experience high workload

  2. ADHD and Present Hedonism: time perspective as a potential diagnostic and therapeutic tool

    Czech Academy of Sciences Publication Activity Database

    Weissenberger, S.; Klicperová-Baker, Martina; Zimbardo, P.G.; Schonova, K.; Akotia, D.; Košťál, Jaroslav; Goetz, M.; Raboch, J.; Ptáček, R.

    -, č. 12 (2016), s. 2963-2971 ISSN 1178-2021 R&D Projects: GA ČR GA15-11062S Institutional support: RVO:68081740 Keywords : ADHD * time perspective * ZTPI * Zimbardo * addiction * alcoholism * delinquency * video games * problematic Internet use Subject RIV: AN - Psychology Impact factor: 2.198, year: 2016

  3. Predicting turnaround time reductions of the diagnostic track in the histopathology laboratory using mathematical modelling

    NARCIS (Netherlands)

    Leeftink, Anne Greetje; Boucherie, Richardus J.; Hans, Elias W.; Verdaasdonk, M.A.M.; Vliegen, Ingrid; Van Diest, P.J

    Background Pathology departments face a growing volume of more and more complex testing in an era where healthcare costs tend to explode and short turnaround times (TATs) are expected. In contrast, the histopathology workforce tends to shrink, so histopathology employees experience high workload

  4. ADHD and Present Hedonism: time perspective as a potential diagnostic and therapeutic tool

    Czech Academy of Sciences Publication Activity Database

    Weissenberger, S.; Klicperová-Baker, Martina; Zimbardo, P.G.; Schonova, K.; Akotia, D.; Košťál, Jaroslav; Goetz, M.; Raboch, J.; Ptáček, R.

    -, č. 12 (2016), s. 2963-2971 ISSN 1178-2021 R&D Projects: GA ČR GA15-11062S Institutional support: RVO:68081740 Keywords : ADHD * time perspective * ZTPI * Zimbardo * addiction * alcohol ism * delinquency * video games * problematic Internet use Subject RIV: AN - Psychology Impact factor: 2.198, year: 2016

  5. Conservative fourth-order time integration of non-linear dynamic systems

    DEFF Research Database (Denmark)

    Krenk, Steen

    2015-01-01

    An energy conserving time integration algorithm with fourth-order accuracy is developed for dynamic systems with nonlinear stiffness. The discrete formulation is derived by integrating the differential state-space equations of motion over the integration time increment, and then evaluating...... the resulting time integrals of the inertia and stiffness terms via integration by parts. This process introduces the time derivatives of the state space variables, and these are then substituted from the original state-space differential equations. The resulting discrete form of the state-space equations...... is a direct fourth-order accurate representation of the original differential equations. This fourth-order form is energy conserving for systems with force potential in the form of a quartic polynomial in the displacement components. Energy conservation for a force potential of general form is obtained...

  6. Integrated Monitoring of Mola mola Behaviour in Space and Time.

    Science.gov (United States)

    Sousa, Lara L; López-Castejón, Francisco; Gilabert, Javier; Relvas, Paulo; Couto, Ana; Queiroz, Nuno; Caldas, Renato; Dias, Paulo Sousa; Dias, Hugo; Faria, Margarida; Ferreira, Filipe; Ferreira, António Sérgio; Fortuna, João; Gomes, Ricardo Joel; Loureiro, Bruno; Martins, Ricardo; Madureira, Luis; Neiva, Jorge; Oliveira, Marina; Pereira, João; Pinto, José; Py, Frederic; Queirós, Hugo; Silva, Daniel; Sujit, P B; Zolich, Artur; Johansen, Tor Arne; de Sousa, João Borges; Rajan, Kanna

    2016-01-01

    Over the last decade, ocean sunfish movements have been monitored worldwide using various satellite tracking methods. This study reports the near-real time monitoring of fine-scale (vehicles to measure both the movements and the contextual environment of the fish. A total of four individuals were tracked using custom-made GPS satellite tags providing geolocation estimates of fine-scale resolution. These accurate positions further informed sunfish areas of restricted search (ARS), which were directly correlated to steep thermal frontal zones. Simultaneously, and for two different occasions, an Autonomous Underwater Vehicle (AUV) video-recorded the path of the tracked fish and detected buoyant particles in the water column. Importantly, the densities of these particles were also directly correlated to steep thermal gradients. Thus, both sunfish foraging behaviour (ARS) and possibly prey densities, were found to be influenced by analogous environmental conditions. In addition, the dynamic structure of the water transited by the tracked individuals was described by a Lagrangian modelling approach. The model informed the distribution of zooplankton in the region, both horizontally and in the water column, and the resultant simulated densities positively correlated with sunfish ARS behaviour estimator (rs = 0.184, pstructure provide a rationale for a predator's fine-scale behaviour observed over a two weeks in May 2014.

  7. Integrated Monitoring of Mola mola Behaviour in Space and Time

    Science.gov (United States)

    Sousa, Lara L.; López-Castejón, Francisco; Gilabert, Javier; Relvas, Paulo; Couto, Ana; Queiroz, Nuno; Caldas, Renato; Dias, Paulo Sousa; Dias, Hugo; Faria, Margarida; Ferreira, Filipe; Ferreira, António Sérgio; Fortuna, João; Gomes, Ricardo Joel; Loureiro, Bruno; Martins, Ricardo; Madureira, Luis; Neiva, Jorge; Oliveira, Marina; Pereira, João; Pinto, José; Py, Frederic; Queirós, Hugo; Silva, Daniel; Sujit, P. B.; Zolich, Artur; Johansen, Tor Arne; de Sousa, João Borges; Rajan, Kanna

    2016-01-01

    Over the last decade, ocean sunfish movements have been monitored worldwide using various satellite tracking methods. This study reports the near-real time monitoring of fine-scale (behaviour of sunfish. The study was conducted in southern Portugal in May 2014 and involved satellite tags and underwater and surface robotic vehicles to measure both the movements and the contextual environment of the fish. A total of four individuals were tracked using custom-made GPS satellite tags providing geolocation estimates of fine-scale resolution. These accurate positions further informed sunfish areas of restricted search (ARS), which were directly correlated to steep thermal frontal zones. Simultaneously, and for two different occasions, an Autonomous Underwater Vehicle (AUV) video-recorded the path of the tracked fish and detected buoyant particles in the water column. Importantly, the densities of these particles were also directly correlated to steep thermal gradients. Thus, both sunfish foraging behaviour (ARS) and possibly prey densities, were found to be influenced by analogous environmental conditions. In addition, the dynamic structure of the water transited by the tracked individuals was described by a Lagrangian modelling approach. The model informed the distribution of zooplankton in the region, both horizontally and in the water column, and the resultant simulated densities positively correlated with sunfish ARS behaviour estimator (rs = 0.184, pbehaviour observed over a two weeks in May 2014. PMID:27494028

  8. A diagnostic for time-resolved spatial profiles measurements on the ion temperature on JET

    International Nuclear Information System (INIS)

    Brocken, H.J.B.M.; Ven, H.W van der.

    1980-05-01

    A neutral particle scattering experiment for a continuous measurement of the ion temperature and ion density of the JET plasma in the hydrogen and deuterium phase is proposed. Space- and time-resolved measurements are possible by injection of a mono-energetic particle beam into the plasma and from the analysis of the velocity distribution of the scattered particles. The requirements on the injection system are specified and a suitable analyzer system is described

  9. Vibration analysis diagnostics by continuous-time models: A case study

    International Nuclear Information System (INIS)

    Pedregal, Diego J.; Carmen Carnero, Ma.

    2009-01-01

    In this paper a forecasting system in condition monitoring is developed based on vibration signals in order to improve the diagnosis of a certain critical equipment at an industrial plant. The system is based on statistical models capable of forecasting the state of the equipment combined with a cost model consisting of defining the time of preventive replacement when the minimum of the expected cost per unit of time is reached in the future. The most relevant features of the system are that (i) it is developed for bivariate signals; (ii) the statistical models are set up in a continuous-time framework, due to the specific nature of the data; and (iii) it has been developed from scratch for a real case study and may be generalised to other pieces of equipment. The system is thoroughly tested on the equipment available, showing its correctness with the data in a statistical sense and its capability of producing sensible results for the condition monitoring programme

  10. Vibration analysis diagnostics by continuous-time models: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Pedregal, Diego J. [Escuela Tecnica Superior de Ingenieros Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain)], E-mail: Diego.Pedregal@uclm.es; Carmen Carnero, Ma. [Escuela Tecnica Superior de Ingenieros Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain)], E-mail: Carmen.Carnero@uclm.es

    2009-02-15

    In this paper a forecasting system in condition monitoring is developed based on vibration signals in order to improve the diagnosis of a certain critical equipment at an industrial plant. The system is based on statistical models capable of forecasting the state of the equipment combined with a cost model consisting of defining the time of preventive replacement when the minimum of the expected cost per unit of time is reached in the future. The most relevant features of the system are that (i) it is developed for bivariate signals; (ii) the statistical models are set up in a continuous-time framework, due to the specific nature of the data; and (iii) it has been developed from scratch for a real case study and may be generalised to other pieces of equipment. The system is thoroughly tested on the equipment available, showing its correctness with the data in a statistical sense and its capability of producing sensible results for the condition monitoring programme.

  11. Laser fusion diagnostics

    International Nuclear Information System (INIS)

    Coleman, L.W.

    1978-01-01

    The current status of the capability of laser fusion diagnostics is reviewed. Optical and infrared streak cameras provide one time resolution measurement capability of less than 10 ps, while x-ray streak cameras provide 15 ps time resolution in the range of about 1--30 keV presently. Time integrated spatial resolutions of 1 μm are provided with a variety of optical techniques. Ultraviolet holographic interferometry has measured electron densities above 10 21 cm -3 with 1 μm spatial resolution and 15 ps temporal resolution. X-ray microscopes provide 3 μm time integrated resolution and the x-ray streak pinhole camera has 6 μm spatial resolution. Development of the framing camera has thus far provided 50 μm spatial resolution with 125 ps frame duration and the third order reconstruction of zone plate images has provided 3 μm resolutions for alpha particles. Time integrated measurements of x-rays span the range shown. Finally, the new Shiva neutron spectrometer increases the energy resolution capability of that technique to 25 keV for 14-MeV neutrons. These combined capabilities provide a unique set of diagnostics for the detailed measurement of the interaction of laser light with targets and a subsequent performance of those targets

  12. Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload

    International Nuclear Information System (INIS)

    Paparo, Francesco; Cevasco, Luca; Zefiro, Daniele; Biscaldi, Ennio; Bacigalupo, Lorenzo; Balocco, Manuela; Pongiglione, Marta; Banderali, Simone; Forni, Gian Luca; Rollandi, Gian Andrea

    2013-01-01

    Objective: The objective of our prospective monocentric work was to determine the diagnostic value of real-time elastography (RTE) in the assessment of liver fibrosis in patients with iron overload, using transient elastography (TE) as reference standard. Methods: Sixty-seven consecutive patients with MRI detectable iron overload (T2* < 6.3 ms) were enrolled. TE and RTE were performed on the same day as MRI. Elastograms were acquired by an experienced operator and analyzed by calculating the elastic ratio between perihepatic soft tissues and liver parenchyma. An elliptical ROI of 1 cm 2 (Z 1 ) was positioned in the liver parenchyma and a smaller elliptical ROI of 2 mm 2 (Z 2 ) was positioned in a homogeneously soft (red) region of the diaphragm, which was considered as internal control to calculate the elastic ratio Z 2 /Z 1 . Results: Seven patients were excluded because of invalid TE or RTE examinations. The remaining 60 patients were 57% males and 43% females (mean age: 42 [21–76] years), including 37 homozygous-β-thalassemics, 13 patients with β-thalassemia intermedia, 6 with primary hemochromatosis, and 4 with myelodysplastic syndrome. Increasing elastic ratios were significantly correlated with increasing TE values (r = 0.645, 95% CI 0.468–0.772, P < 0.0001). The mean elastic ratios for each METAVIR group were as follows: F0/1 = 1.9 ± 0.4; F2 = 2.2 ± 0.4; F3 = 2.9 ± 0.5; F4 = 3.2 ± 0.4. The diagnostic accuracy of RTE for F ≥ 2 evaluated by AUC-ROC analysis was 0.798 (95% CI 0.674–0.890). The diagnostic accuracy of RTE for F ≥ 3 was 0.909 (95% CI 0.806–0.968). At a cut-off ≥ 2.75, RTE showed a sensitivity of 70% (95% CI 45.7–88.1) and a specificity of 97.5% (95% CI 86.8–99.9). Conclusions: In patients with MRI-detectable liver iron-overload RTE allows to discriminate between F0/1–F2 and F3–F4 with a reasonable diagnostic accuracy

  13. Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload

    Energy Technology Data Exchange (ETDEWEB)

    Paparo, Francesco [Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Cevasco, Luca [School of Radiology, University of Genoa, Via Leon Battista Alberti 4, 16132 Genoa (Italy); Zefiro, Daniele [Medical Physics Department, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Biscaldi, Ennio; Bacigalupo, Lorenzo [Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Balocco, Manuela [Unit of Microcitemia and Hereditary Anaemias, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Pongiglione, Marta; Banderali, Simone [Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Forni, Gian Luca [Unit of Microcitemia and Hereditary Anaemias, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy); Rollandi, Gian Andrea, E-mail: gian.andrea.rollandi@galliera.it [Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa (Italy)

    2013-12-01

    Objective: The objective of our prospective monocentric work was to determine the diagnostic value of real-time elastography (RTE) in the assessment of liver fibrosis in patients with iron overload, using transient elastography (TE) as reference standard. Methods: Sixty-seven consecutive patients with MRI detectable iron overload (T2* < 6.3 ms) were enrolled. TE and RTE were performed on the same day as MRI. Elastograms were acquired by an experienced operator and analyzed by calculating the elastic ratio between perihepatic soft tissues and liver parenchyma. An elliptical ROI of 1 cm{sup 2} (Z{sub 1}) was positioned in the liver parenchyma and a smaller elliptical ROI of 2 mm{sup 2} (Z{sub 2}) was positioned in a homogeneously soft (red) region of the diaphragm, which was considered as internal control to calculate the elastic ratio Z{sub 2}/Z{sub 1}. Results: Seven patients were excluded because of invalid TE or RTE examinations. The remaining 60 patients were 57% males and 43% females (mean age: 42 [21–76] years), including 37 homozygous-β-thalassemics, 13 patients with β-thalassemia intermedia, 6 with primary hemochromatosis, and 4 with myelodysplastic syndrome. Increasing elastic ratios were significantly correlated with increasing TE values (r = 0.645, 95% CI 0.468–0.772, P < 0.0001). The mean elastic ratios for each METAVIR group were as follows: F0/1 = 1.9 ± 0.4; F2 = 2.2 ± 0.4; F3 = 2.9 ± 0.5; F4 = 3.2 ± 0.4. The diagnostic accuracy of RTE for F ≥ 2 evaluated by AUC-ROC analysis was 0.798 (95% CI 0.674–0.890). The diagnostic accuracy of RTE for F ≥ 3 was 0.909 (95% CI 0.806–0.968). At a cut-off ≥ 2.75, RTE showed a sensitivity of 70% (95% CI 45.7–88.1) and a specificity of 97.5% (95% CI 86.8–99.9). Conclusions: In patients with MRI-detectable liver iron-overload RTE allows to discriminate between F0/1–F2 and F3–F4 with a reasonable diagnostic accuracy.

  14. Integrated Monitoring of Mola mola Behaviour in Space and Time.

    Directory of Open Access Journals (Sweden)

    Lara L Sousa

    Full Text Available Over the last decade, ocean sunfish movements have been monitored worldwide using various satellite tracking methods. This study reports the near-real time monitoring of fine-scale (< 10 m behaviour of sunfish. The study was conducted in southern Portugal in May 2014 and involved satellite tags and underwater and surface robotic vehicles to measure both the movements and the contextual environment of the fish. A total of four individuals were tracked using custom-made GPS satellite tags providing geolocation estimates of fine-scale resolution. These accurate positions further informed sunfish areas of restricted search (ARS, which were directly correlated to steep thermal frontal zones. Simultaneously, and for two different occasions, an Autonomous Underwater Vehicle (AUV video-recorded the path of the tracked fish and detected buoyant particles in the water column. Importantly, the densities of these particles were also directly correlated to steep thermal gradients. Thus, both sunfish foraging behaviour (ARS and possibly prey densities, were found to be influenced by analogous environmental conditions. In addition, the dynamic structure of the water transited by the tracked individuals was described by a Lagrangian modelling approach. The model informed the distribution of zooplankton in the region, both horizontally and in the water column, and the resultant simulated densities positively correlated with sunfish ARS behaviour estimator (rs = 0.184, p<0.001. The model also revealed that tracked fish opportunistically displace with respect to subsurface current flow. Thus, we show how physical forcing and current structure provide a rationale for a predator's fine-scale behaviour observed over a two weeks in May 2014.

  15. Accurate, Fast and Cost-Effective Diagnostic Test for Monosomy 1p36 Using Real-Time Quantitative PCR

    Directory of Open Access Journals (Sweden)

    Pricila da Silva Cunha

    2014-01-01

    Full Text Available Monosomy 1p36 is considered the most common subtelomeric deletion syndrome in humans and it accounts for 0.5–0.7% of all the cases of idiopathic intellectual disability. The molecular diagnosis is often made by microarray-based comparative genomic hybridization (aCGH, which has the drawback of being a high-cost technique. However, patients with classic monosomy 1p36 share some typical clinical characteristics that, together with its common prevalence, justify the development of a less expensive, targeted diagnostic method. In this study, we developed a simple, rapid, and inexpensive real-time quantitative PCR (qPCR assay for targeted diagnosis of monosomy 1p36, easily accessible for low-budget laboratories in developing countries. For this, we have chosen two target genes which are deleted in the majority of patients with monosomy 1p36: PRKCZ and SKI. In total, 39 patients previously diagnosed with monosomy 1p36 by aCGH, fluorescent in situ hybridization (FISH, and/or multiplex ligation-dependent probe amplification (MLPA all tested positive on our qPCR assay. By simultaneously using these two genes we have been able to detect 1p36 deletions with 100% sensitivity and 100% specificity. We conclude that qPCR of PRKCZ and SKI is a fast and accurate diagnostic test for monosomy 1p36, costing less than 10 US dollars in reagent costs.

  16. Clinical data miner: an electronic case report form system with integrated data preprocessing and machine-learning libraries supporting clinical diagnostic model research.

    Science.gov (United States)

    Installé, Arnaud Jf; Van den Bosch, Thierry; De Moor, Bart; Timmerman, Dirk

    2014-10-20

    Using machine-learning techniques, clinical diagnostic model research extracts diagnostic models from patient data. Traditionally, patient data are often collected using electronic Case Report Form (eCRF) systems, while mathematical software is used for analyzing these data using machine-learning techniques. Due to the lack of integration between eCRF systems and mathematical software, extracting diagnostic models is a complex, error-prone process. Moreover, due to the complexity of this process, it is usually only performed once, after a predetermined number of data points have been collected, without insight into the predictive performance of the resulting models. The objective of the study of Clinical Data Miner (CDM) software framework is to offer an eCRF system with integrated data preprocessing and machine-learning libraries, improving efficiency of the clinical diagnostic model research workflow, and to enable optimization of patient inclusion numbers through study performance monitoring. The CDM software framework was developed using a test-driven development (TDD) approach, to ensure high software quality. Architecturally, CDM's design is split over a number of modules, to ensure future extendability. The TDD approach has enabled us to deliver high software quality. CDM's eCRF Web interface is in active use by the studies of the International Endometrial Tumor Analysis consortium, with over 4000 enrolled patients, and more studies planned. Additionally, a derived user interface has been used in six separate interrater agreement studies. CDM's integrated data preprocessing and machine-learning libraries simplify some otherwise manual and error-prone steps in the clinical diagnostic model research workflow. Furthermore, CDM's libraries provide study coordinators with a method to monitor a study's predictive performance as patient inclusions increase. To our knowledge, CDM is the only eCRF system integrating data preprocessing and machine-learning libraries

  17. Acceptability and Feasibility of Integrating Point-of-Care Diagnostic Testing of Sexually Transmitted Infections into a South African Antenatal Care Program for HIV-Infected Pregnant Women

    Directory of Open Access Journals (Sweden)

    E. Morikawa

    2018-01-01

    Full Text Available Background. Chlamydia trachomatis (CT, Neisseria gonorrhoeae (NG, and Trichomonas vaginalis (TV infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV. In resource-limited settings, symptomatic screening, and syndromic management of sexually transmitted infections (STIs during pregnancy continue to be the standard of care. In the absence of diagnostic testing, asymptomatic infections in pregnant women go untreated. Objective. To describe the acceptability and feasibility of integrating diagnostic STI screening into first antenatal care visits for HIV-infected pregnant women. Methods. HIV-infected pregnant women were recruited during their first antenatal care visit from three antenatal care clinics in Tshwane District, South Africa, between June 2016 and October 2017. Self-collected vaginal swabs were used to screen for CT, NG, and TV with a diagnostic point-of-care (POC nucleic acid amplification test. Those with STIs were provided treatment per South African national guidelines. Results. Of 442 eligible women, 430 (97.3% agreed to participate and were tested. Of those with a positive STI test result (n = 173; 40.2%, 159 (91.9% received same-day results and treatment; 100% of STI-infected women were treated within seven days. Conclusions. Integration of POC diagnostic STI screening into first-visit antenatal care services was feasible and highly acceptable for HIV-infected pregnant women.

  18. Velocity time integral for right upper pulmonary vein in VLBW infants with patent ductus arteriosus

    Directory of Open Access Journals (Sweden)

    Gianluca Lista

    Full Text Available OBJECTIVE: Early diagnosis of significant patent ductus arteriosus reduces the risk of clinical worsening in very low birth weight infants. Echocardiographic patent ductus arteriosus shunt flow pattern can be used to predict significant patent ductus arteriosus. Pulmonary venous flow, expressed as vein velocity time integral, is correlated to ductus arteriosus closure. The aim of this study is to investigate the relationship between significant reductions in vein velocity time integral and non-significant patent ductus arteriosus in the first week of life. METHODS: A multicenter, prospective, observational study was conducted to evaluate very low birth weight infants (<1500 g on respiratory support. Echocardiography was used to evaluate vein velocity time integral on days 1 and 4 of life. The relationship between vein velocity time integral and other parameters was studied. RESULTS: In total, 98 very low birth weight infants on respiratory support were studied. On day 1 of life, vein velocity time integral was similar in patients with open or closed ductus. The mean vein velocity time integral significantly reduced in the first four days of life. On the fourth day of life, there was less of a reduction in patients with patent ductus compared to those with closed patent ductus arteriosus and the difference was significant. CONCLUSIONS: A significant reduction in vein velocity time integral in the first days of life is associated with ductus closure. This parameter correlates well with other echocardiographic parameters and may aid in the diagnosis and management of patent ductus arteriosus.

  19. The Diagnostic Value of Capillary Refill Time for Detecting Serious Illness in Children: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Fleming, Susannah; Gill, Peter; Jones, Caroline; Taylor, James A.; Van den Bruel, Ann; Heneghan, Carl; Roberts, Nia; Thompson, Matthew

    2015-01-01

    Importance Capillary refill time (CRT) is widely recommended as part of the routine assessment of unwell children. Objective To determine the diagnostic value of capillary refill time for a range of serious outcomes in children. Methods We searched Medline, Embase and CINAHL from inception to June 2014. We included studies that measured both capillary refill time and a relevant clinical outcome such as mortality, dehydration, meningitis, or other serious illnesses in children aged up to 18 years of age. We screened 1,265 references, of which 24 papers were included in this review. Where sufficient studies were available, we conducted meta-analysis and constructed hierarchical summary ROC curves. Results Meta-analysis on the relationship between capillary refill time and mortality resulted in sensitivity of 34.6% (95% CI 23.9 to 47.1%), specificity 92.3% (88.6 to 94.8%), positive likelihood ratio 4.49 (3.06 to 6.57), and negative likelihood ratio 0.71 (0.60 to 0.84). Studies of children attending Emergency Departments with vomiting and diarrhea showed that capillary refill time had specificity of 89 to 94% for identifying 5% dehydration, but sensitivity ranged from 0 to 94%. This level of heterogeneity precluded formal meta-analysis of this outcome. Meta-analysis was not possible for other outcomes due to insufficient data, but we found consistently high specificity for a range of outcomes including meningitis, sepsis, admission to hospital, hypoxia, severity of illness and dengue. Conclusions Our results show that capillary refill time is a specific sign, indicating that it can be used as a “red-flag”: children with prolonged capillary refill time have a four-fold risk of dying compared to children with normal capillary refill time. The low sensitivity means that a normal capillary refill time should not reassure clinicians. PMID:26375953

  20. Time resolved diagnostics and kinetic modelling of a modulated hollow cathode discharge of NO2

    International Nuclear Information System (INIS)

    Castillo, M; Herrero, V J; Mendez, I; Tanarro, I

    2004-01-01

    The transients associated with the ignition and the extinction of the cold plasma produced in a low frequency, square-wave modulated, hollow cathode discharge of nitrogen dioxide are characterized by time resolved emission spectroscopy, mass spectrometry and electrical probes. The temporal evolution of the concentrations of neutral species created or destroyed in the NO 2 discharges are compared with the predictions of a simple kinetic model previously developed for discharges of other nitrogen oxides (N 2 O and NO). The physical conditions of pressure, gas flow rate, modulation frequency and electrical current in the NO 2 plasma were selected in order to highlight the time-dependent behaviour of some of the stable species formed in the discharge, especially the nitrogen oxide products, whose concentrations show transient maxima. The usefulness of the analysis of the transient results is emphasized as a means to evaluate the relevance of the different elementary processes and as a key to estimate the values of some of the rate constants critical to the modelling. This work is dedicated to the memory of Professor Jose Campos

  1. Integrated vendor-buyer inventory models with inflation and time value of money in controllable lead time

    Directory of Open Access Journals (Sweden)

    Prashant Jindal

    2016-01-01

    Full Text Available In the global critical economic scenario, inflation plays a vital role in deciding optimal pricing of goods in any business entity. This article presents two single-vendor single-buyer integrated supply chain inventory models with inflation and time value of money. Shortage is allowed during the lead-time and it is partially backlogged. Lead time is controllable and can be reduced using crashing cost. In the first model, we consider the demand of lead time follows a normal distribution, and in the second model, it is considered distribution-free. For both cases, our objective is to minimize the integrated system cost by simultaneously optimizing the order quantity, safety factor, lead time and number of lots. The discounted cash flow and classical optimization technique are used to derive the optimal solution for both cases. Numerical examples including the sensitivity analysis of system parameters is provided to validate the results of the supply chain models.

  2. Beam diagnostics based on time-domain bunch-by-bunch data

    International Nuclear Information System (INIS)

    Teytelman, D.; Fox, J.; Hindi, H.; Limborg, C.; Linscott, I.; Prabhakar, S.; Sebek, J.; Young, A.; Drago, A.; Serio, M.; Barry, W.; Stover, G.

    1998-01-01

    A bunch-by-bunch longitudinal feedback system has been used to control coupled-bunch longitudinal motion and study the behavior of the beam at ALS, SPEAR, PEP-II, and DAΦNE. Each of these machines presents unique challenges to feedback control of unstable motion and data analysis. Here we present techniques developed to adapt this feedback system to operating conditions at these accelerators. A diverse array of techniques has been developed to extract information on different aspects of beam behavior from the time-domain data captured by the feedback system. These include measurements of growth and damping rates of coupled-bunch modes, bunch-by-bunch current monitoring, measurements of bunch-by-bunch synchronous phases and longitudinal tunes, and beam noise spectra. A technique is presented which uses the longitudinal feedback system to measure transverse growth and damping rates. Techniques are illustrated with data acquired at all of the four above-mentioned machines

  3. Degree of vertical integration between the undergraduate program and clinical internship with respect to cervical and cranial diagnostic and therapeutic procedures taught at the canadian memorial chiropractic college.

    Science.gov (United States)

    Leppington, Charmody; Gleberzon, Brian; Fortunato, Lisa; Doucet, Nicolea; Vandervalk, Kyle

    2012-01-01

    The purpose of this study was to determine if diagnostic and therapeutic procedures for the cervical and cranial spine taught to students during the undergraduate program at Canadian Memorial Chiropractic College are required to be used during their internship by their supervising clinicians and, if so, to what extent these procedures are used. Course manuals and course syllabi from the Applied Chiropractic and Clinical Diagnosis faculty of the undergraduate chiropractic program for the academic year 2009-2010 were consulted and a list of all diagnostic and therapeutic procedures for the cranial and cervical spine was compiled. This survey asked clinicians to indicate if they themselves used or if they required the students they were supervising to use each procedure listed and, if so, to what extent each procedure was used. Demographic information of each clinician was also obtained. In general, most diagnostic procedures of the head and neck were seldom used, with the exception of postural observation and palpation. By contrast, most cervical orthopaedic tests were often used, with the exception of tests for vertigo. Most therapeutic procedures were used frequently with the exception of prone cervical and "muscle" adjustments. There was a low degree of vertical integration for cranial procedures as compared to a much higher degree of vertical integration for cervical procedures between the undergraduate and clinical internship programs taught. Vertical integration is an important element of curricular planning and these results may be helpful to aid educators to more appropriately allocate classroom instruction.

  4. An assessment of the 3D geometric surrogacy of shock timing diagnostic techniques for tuning experiments on the NIF

    Energy Technology Data Exchange (ETDEWEB)

    Robey, H F; Munro, D H; Spears, B K; Marinak, M M; Jones, O S; Patel, M V; Haan, S W; Salmonson, J D; Landen, O L [Lawrence Livermore National Laboratory, Livermore, CA (United States); Boehly, T R [Laboratory for Laser Energetics, Rochester, NY (United States); Nikroo, A [General Atomics, San Diego, CA (United States)], E-mail: robey1@llnl.gov

    2008-05-15

    Ignition capsule implosions planned for the National Ignition Facility (NIF) require a pulse shape with a carefully designed series of four steps, which launch a corresponding series of shocks through the ablator and DT ice shell. The relative timing of these shocks is critical for maintaining the DT fuel on a low adiabat. The current NIF specification requires that the timing of all four shocks be tuned to an accuracy of {<=} +/- 100ps. To meet these stringent requirements, dedicated tuning experiments are being planned to measure and adjust the shock timing on NIF. These tuning experiments will be performed in a modified hohlraum geometry, where a re-entrant Au cone is added to the standard NIF hohlraum to provide optical diagnostic (VISAR and SOP) access to the shocks as they break out of the ablator. This modified geometry is referred to as the 'keyhole' hohlraum and introduces a geometric difference between these tuning-experiments and the full ignition geometry. In order to assess the surrogacy of this modified geometry, 3D simulations using HYDRA [1] have been performed. The results from simulations of a quarter of the target geometry are presented. Comparisons of the hohlraum drive conditions and the resulting effect on the shock timing in the keyhole hohlraum are compared with the corresponding results for the standard ignition hohlraum.

  5. An assessment of the 3D geometric surrogacy of shock timing diagnostic techniques for tuning experiments on the NIF

    International Nuclear Information System (INIS)

    Robey, H F; Munro, D H; Spears, B K; Marinak, M M; Jones, O S; Patel, M V; Haan, S W; Salmonson, J D; Landen, O L; Boehly, T R; Nikroo, A

    2008-01-01

    Ignition capsule implosions planned for the National Ignition Facility (NIF) require a pulse shape with a carefully designed series of four steps, which launch a corresponding series of shocks through the ablator and DT ice shell. The relative timing of these shocks is critical for maintaining the DT fuel on a low adiabat. The current NIF specification requires that the timing of all four shocks be tuned to an accuracy of ≤ +/- 100ps. To meet these stringent requirements, dedicated tuning experiments are being planned to measure and adjust the shock timing on NIF. These tuning experiments will be performed in a modified hohlraum geometry, where a re-entrant Au cone is added to the standard NIF hohlraum to provide optical diagnostic (VISAR and SOP) access to the shocks as they break out of the ablator. This modified geometry is referred to as the 'keyhole' hohlraum and introduces a geometric difference between these tuning-experiments and the full ignition geometry. In order to assess the surrogacy of this modified geometry, 3D simulations using HYDRA [1] have been performed. The results from simulations of a quarter of the target geometry are presented. Comparisons of the hohlraum drive conditions and the resulting effect on the shock timing in the keyhole hohlraum are compared with the corresponding results for the standard ignition hohlraum

  6. Reparametrization in the path integral over finite dimensional manifold with a time-dependent metric

    International Nuclear Information System (INIS)

    Storchak, S.N.

    1988-01-01

    The path reparametrization procedure in the path integral is considered using the methods of stochastic processes for diffusion on finite dimensional manifold with a time-dependent metric. the reparametrization Jacobian has been obtained. The formulas of reparametrization for a symbolic presentation of the path integral have been derived

  7. Non-integrability of time-dependent spherically symmetric Yang-Mills equations

    International Nuclear Information System (INIS)

    Matinyan, S.G.; Prokhorenko, E.V.; Savvidy, G.K.

    1986-01-01

    The integrability of time-dependent spherically symmetric Yang-Mills equations is studied using the Fermi-Pasta-Ulam method. The phase space of this system is shown to have no quasi-periodic motion specific for integrable systems. In particular, the well-known Wu-Yang static solution is unstable, so its vicinity in phase is the stochasticity region

  8. Non-integrability of time-dependent spherically symmetric Yang-Mills equations

    Energy Technology Data Exchange (ETDEWEB)

    Matinyan, S G; Prokhorenko, E B; Savvidy, G K

    1988-03-07

    The integrability of time-dependent spherically symmetric Yang-Mills equations is studied using the Fermi-Pasta-Ulam method. It is shown that the motion of this system is ergodic, while the system itself is non-integrable, i.e. manifests dynamical chaos.

  9. Beam diagnostics based on time-domain bunch-by-bunch data

    International Nuclear Information System (INIS)

    Teytelman, D.; Fox, J.; Hindi, H.; Limborg, C.; Linscott, I.; Prabhakar, S.; Sebek, J.; Young, A.; Drago, A.; Serio, M.; Barry, W.; Stover, G.

    1998-01-01

    A bunch-by-bunch longitudinal feedback system has been used to control coupled-bunch longitudinal motion and study the behavior of the beam at ALS, SPEAR, PEP-II, and DAΦNE. Each of these machines presents unique challenges to feedback control of unstable motion and data analysis. Here we present techniques developed to adapt this feedback system to operating conditions at these accelerators. A diverse array of techniques has been developed to extract information on different aspects of beam behavior from the time-domain data captured by the feedback system. These include measurements of growth and damping rates of coupled-bunch modes, bunch-by-bunch current monitoring, measurements of bunch-by-bunch synchronous phases and longitudinal tunes, and beam noise spectra. A technique is presented which uses the longitudinal feedback system to measure transverse growth and damping rates. Techniques are illustrated with data acquired at all of the four above-mentioned machines. copyright 1998 American Institute of Physics

  10. Neutron time-of-flight counters and spectrometers for diagnostics of burning fusion plasmas

    International Nuclear Information System (INIS)

    Elevant, T.; Olsson, M.

    1991-02-01

    Experiment with burning fusion plasmas in tokamaks will place particular requirements on neutron measurements from radiation resistance-, physics-, burn control- and reliability considerations. The possibility to meet these needs by measurements of neutron fluxes and energy spectra by means of time-of-flight techniques are described. Reference counters and spectrometers are proposed and characterized with respect to efficiency, count-rate capabilities, energy resolution and tolerable neutron and γ-radiation background levels. The instruments can be used in a neutron camera and are capable to operate in collimated neutron fluxes up to levels corresponding to full nuclear output power in the next generation of experiments. Energy resolutions of the spectrometers enables determination of ion temperatures from 3 (keV) through analysis of the Doppler broadening. Primarily, the instruments are aimed for studies of 14 (MeV) neutrons produced in (d,t)-plasmas but can, after minor modifications, be used for analysis of 2.45 (MeV) neutrons produced in (d,d)-plasma. (au) (33 refs.)

  11. Utilising symptom dimensions with diagnostic categories improves prediction of time to first remission in first-episode psychosis.

    Science.gov (United States)

    Ajnakina, Olesya; Lally, John; Di Forti, Marta; Stilo, Simona A; Kolliakou, Anna; Gardner-Sood, Poonam; Dazzan, Paola; Pariante, Carmine; Reis Marques, Tiago; Mondelli, Valeria; MacCabe, James; Gaughran, Fiona; David, Anthony S; Stamate, Daniel; Murray, Robin M; Fisher, Helen L

    2018-03-01

    There has been much recent debate concerning the relative clinical utility of symptom dimensions versus conventional diagnostic categories in patients with psychosis. We investigated whether symptom dimensions rated at presentation for first-episode psychosis (FEP) better predicted time to first remission than categorical diagnosis over a four-year follow-up. The sample comprised 193 FEP patients aged 18-65years who presented to psychiatric services in South London, UK, between 2006 and 2010. Psychopathology was assessed at baseline with the Positive and Negative Syndrome Scale and five symptom dimensions were derived using Wallwork/Fortgang's model; baseline diagnoses were grouped using DSM-IV codes. Time to start of first remission was ascertained from clinical records. The Bayesian Information Criterion (BIC) was used to find the best fitting accelerated failure time model of dimensions, diagnoses and time to first remission. Sixty percent of patients remitted over the four years following first presentation to psychiatric services, and the average time to start of first remission was 18.3weeks (SD=26.0, median=8). The positive (BIC=166.26), excited (BIC=167.30) and disorganised/concrete (BIC=168.77) symptom dimensions, and a diagnosis of schizophrenia (BIC=166.91) predicted time to first remission. However, a combination of the DSM-IV diagnosis of schizophrenia with all five symptom dimensions led to the best fitting model (BIC=164.35). Combining categorical diagnosis with symptom dimension scores in FEP patients improved the accuracy of predicting time to first remission. Thus our data suggest that the decision to consign symptom dimensions to an annexe in DSM-5 should be reconsidered at the earliest opportunity. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. 3D printing and milling a real-time PCR device for infectious disease diagnostics.

    Science.gov (United States)

    Mulberry, Geoffrey; White, Kevin A; Vaidya, Manjusha; Sugaya, Kiminobu; Kim, Brian N

    2017-01-01

    Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device. The key advantage of this approach is the ability to upload the digital format of the design files on the internet for wide distribution so that people at any location can simply download and feed into their 3D printers for quick manufacturing. The material and design are carefully selected to minimize the number of custom parts that depend on advanced manufacturing processes which lower accessibility. The presented 3D manufactured qPCR device is tested with 20-μL samples that contain various concentrations of lentivirus, the same type as HIV. A reverse-transcription step is a part of the device's operation, which takes place prior to the qPCR step to reverse transcribe the target RNA from the lentivirus into complementary DNA (cDNA). This is immediately followed by qPCR which quantifies the target sequence molecules in the sample during the PCR amplification process. The entire process of thermal control and time-coordinated fluorescence reading is automated by closed-loop feedback and a microcontroller. The resulting device is portable and battery-operated, with a size of 12 × 7 × 6 cm3 and mass of only 214 g. By uploading and sharing the design files online, the presented low-cost qPCR device may provide easier access to a robust diagnosis protocol for various infectious diseases, such as HIV and malaria.

  13. 3D printing and milling a real-time PCR device for infectious disease diagnostics

    Science.gov (United States)

    Mulberry, Geoffrey; White, Kevin A.; Vaidya, Manjusha; Sugaya, Kiminobu

    2017-01-01

    Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device. The key advantage of this approach is the ability to upload the digital format of the design files on the internet for wide distribution so that people at any location can simply download and feed into their 3D printers for quick manufacturing. The material and design are carefully selected to minimize the number of custom parts that depend on advanced manufacturing processes which lower accessibility. The presented 3D manufactured qPCR device is tested with 20-μL samples that contain various concentrations of lentivirus, the same type as HIV. A reverse-transcription step is a part of the device’s operation, which takes place prior to the qPCR step to reverse transcribe the target RNA from the lentivirus into complementary DNA (cDNA). This is immediately followed by qPCR which quantifies the target sequence molecules in the sample during the PCR amplification process. The entire process of thermal control and time-coordinated fluorescence reading is automated by closed-loop feedback and a microcontroller. The resulting device is portable and battery-operated, with a size of 12 × 7 × 6 cm3 and mass of only 214 g. By uploading and sharing the design files online, the presented low-cost qPCR device may provide easier access to a robust diagnosis protocol for various infectious diseases, such as HIV and malaria. PMID:28586401

  14. Methane, Ethane, and Propane Sensor for Real-time Leak Detection and Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Roscioli, Joseph R. [Aerodyne Research, Inc., Billerica, MA (United States); Herndon, Scott [Aerodyne Research, Inc., Billerica, MA (United States); Nelson, David D. [Aerodyne Research, Inc., Billerica, MA (United States); Yacovitch, Tara [Aerodyne Research, Inc., Billerica, MA (United States)

    2017-03-24

    monitor was designed based upon the commercial compact mini-spectrometer capable of dual-laser operation. We intend to build and test this during phase II. Multiple opportunities for improvement were also identified. First, the reported ethane and propane concentrations are susceptible to external acceleration acting upon the instrument. During phase II we will address this “motion-sickness”. Second, significant software development will be needed operate the monitor at 1 second resolution in real time, and provide rapid, actionable data to a driver or passenger.

  15. Optimal distribution of integration time for intensity measurements in degree of linear polarization polarimetry.

    Science.gov (United States)

    Li, Xiaobo; Hu, Haofeng; Liu, Tiegen; Huang, Bingjing; Song, Zhanjie

    2016-04-04

    We consider the degree of linear polarization (DOLP) polarimetry system, which performs two intensity measurements at orthogonal polarization states to estimate DOLP. We show that if the total integration time of intensity measurements is fixed, the variance of the DOLP estimator depends on the distribution of integration time for two intensity measurements. Therefore, by optimizing the distribution of integration time, the variance of the DOLP estimator can be decreased. In this paper, we obtain the closed-form solution of the optimal distribution of integration time in an approximate way by employing Delta method and Lagrange multiplier method. According to the theoretical analyses and real-world experiments, it is shown that the variance of the DOLP estimator can be decreased for any value of DOLP. The method proposed in this paper can effectively decrease the measurement variance and thus statistically improve the measurement accuracy of the polarimetry system.

  16. Optimal distribution of integration time for intensity measurements in Stokes polarimetry.

    Science.gov (United States)

    Li, Xiaobo; Liu, Tiegen; Huang, Bingjing; Song, Zhanjie; Hu, Haofeng

    2015-10-19

    We consider the typical Stokes polarimetry system, which performs four intensity measurements to estimate a Stokes vector. We show that if the total integration time of intensity measurements is fixed, the variance of the Stokes vector estimator depends on the distribution of the integration time at four intensity measurements. Therefore, by optimizing the distribution of integration time, the variance of the Stokes vector estimator can be decreased. In this paper, we obtain the closed-form solution of the optimal distribution of integration time by employing Lagrange multiplier method. According to the theoretical analysis and real-world experiment, it is shown that the total variance of the Stokes vector estimator can be significantly decreased about 40% in the case discussed in this paper. The method proposed in this paper can effectively decrease the measurement variance and thus statistically improves the measurement accuracy of the polarimetric system.

  17. On the mixed discretization of the time domain magnetic field integral equation

    KAUST Repository

    Ulku, Huseyin Arda; Bogaert, Ignace; Cools, Kristof; Andriulli, Francesco P.; Bagci, Hakan

    2012-01-01

    Time domain magnetic field integral equation (MFIE) is discretized using divergence-conforming Rao-Wilton-Glisson (RWG) and curl-conforming Buffa-Christiansen (BC) functions as spatial basis and testing functions, respectively. The resulting mixed

  18. Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

    KAUST Repository

    Valdé s, Felipe; Andriulli, Francesco P.; Bagci, Hakan; Michielssen, Eric

    2013-01-01

    Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis

  19. Time-integrated CP violation measurements in the B mesons system at the LHCb experiment

    CERN Document Server

    Cardinale, R

    2016-01-01

    Time-integrated CP violation measurements in the B meson system provide information for testing the CKM picture of CP violation in the Standard Model. A review of recent results from the LHCb experiment is presented.

  20. Real-Time X-ray Radiography Diagnostics of Components in Solid Rocket Motors

    Science.gov (United States)

    Cortopassi, A. C.; Martin, H. T.; Boyer, E.; Kuo, K. K.

    2012-01-01

    the recession of the solid propellant grain can drastically alter the flow-field and effect the recession of internal insulation and nozzle materials. Simultaneous measurement of the overall erosion rate, the development of the char layer, and the recession of the char-virgin interface during the motor operation can be rather difficult. While invasive techniques have been used with limited success, they have serious drawbacks. Break wires or make wire sensors can be installed into a sufficient number of locations in the charring material from which a time history of the charring surface can be deduced. These sensors fundamentally alter the local structure of the material in which they are imbedded. Also, the location of these sensors within the material is not known precisely without the use of an X-ray. To determine instantaneous recession rates, real-time X-ray radiography (X-ray RTR) has been utilized in several SRM experiments at PSU. The X-ray RTR system discussed in this paper consists of an X-ray source, X-ray image intensifier, and CCD camera connected to a capture computer. The system has been used to examine the ablation process of internal insulation as well as nozzle material erosion in a subscale SRM. The X-ray source is rated to 320 kV at 10 mA and has both a large (5.5 mm) and small (3.0 mm) focal spot. The lead-lined cesium iodide X-ray image intensifier produces an image which is captured by a CCD camera with a 1,000 x 1,000 pixel resolution. To produce accurate imagery of the object of interest, the alignment of the X-ray source to the X-ray image intensifier is crucial. The image sequences captured during the operation of an SRM are then processed to enhance the quality of the images. This procedure allows for computer software to extract data on the total erosion rate and the char layer thickness. Figure 1 Error! Reference source not found.shows a sequence of images captured during the operation the subscale SRM with the X-ray RTR system. The X

  1. The effect of decaying atomic states on integral and time differential Moessbauer spectra

    International Nuclear Information System (INIS)

    Kankeleit, E.

    1975-01-01

    Moessbauer spectra for time dependent monopole interaction have been calculated for the case that the nuclear transition feeding the Moessbauer state excites an electric state of the atom. This is assumed to decay in a time comparable with the lifetime of the Moessbauer state. Spectra have been calculated for both time differential and integral experiments. (orig.) [de

  2. Terminal current interpolation for multirate time integration of hierarchical IC models

    NARCIS (Netherlands)

    Verhoeven, A.; Maten, ter E.J.W.; Dohmen, J.J.; Tasic, B.; Mattheij, R.M.M.; Fitt, A.D.; Norbury, J.; Ockendon, H.; Wilson, E.

    2010-01-01

    Multirate time-integration methods [3–5] appear to be attractive for initial value problems for DAEs with latency or multirate behaviour. Latency means that parts of the circuit are constant or slowly time-varying during a certain time interval, while multirate behaviour means that some variables

  3. Marching on-in-time solution of the time domain magnetic field integral equation using a predictor-corrector scheme

    KAUST Repository

    Ulku, Huseyin Arda; Bagci, Hakan; Michielssen, Eric

    2013-01-01

    An explicit marching on-in-time (MOT) scheme for solving the time-domain magnetic field integral equation (TD-MFIE) is presented. The proposed MOT-TD-MFIE solver uses Rao-Wilton-Glisson basis functions for spatial discretization and a PE(CE)m-type linear multistep method for time marching. Unlike previous explicit MOT-TD-MFIE solvers, the time step size can be chosen as large as that of the implicit MOT-TD-MFIE solvers without adversely affecting accuracy or stability. An algebraic stability analysis demonstrates the stability of the proposed explicit solver; its accuracy and efficiency are established via numerical examples. © 1963-2012 IEEE.

  4. Marching on-in-time solution of the time domain magnetic field integral equation using a predictor-corrector scheme

    KAUST Repository

    Ulku, Huseyin Arda

    2013-08-01

    An explicit marching on-in-time (MOT) scheme for solving the time-domain magnetic field integral equation (TD-MFIE) is presented. The proposed MOT-TD-MFIE solver uses Rao-Wilton-Glisson basis functions for spatial discretization and a PE(CE)m-type linear multistep method for time marching. Unlike previous explicit MOT-TD-MFIE solvers, the time step size can be chosen as large as that of the implicit MOT-TD-MFIE solvers without adversely affecting accuracy or stability. An algebraic stability analysis demonstrates the stability of the proposed explicit solver; its accuracy and efficiency are established via numerical examples. © 1963-2012 IEEE.

  5. Design of a semi-custom integrated circuit for the SLAC SLC timing control system

    International Nuclear Information System (INIS)

    Linstadt, E.

    1984-10-01

    A semi-custom (gate array) integrated circuit has been designed for use in the SLAC Linear Collider timing and control system. The design process and SLAC's experiences during the phases of the design cycle are described. Issues concerning the partitioning of the design into semi-custom and standard components are discussed. Functional descriptions of the semi-custom integrated circuit and the timing module in which it is used are given

  6. SEMIGROUPS N TIMES INTEGRATED AND AN APPLICATION TO A PROBLEM OF CAUCHY TYPE

    Directory of Open Access Journals (Sweden)

    Danessa Chirinos Fernández

    2016-06-01

    Full Text Available The theory of semigroups n times integrated is a generalization of strongly continuous semigroups, which was developed from 1984, and is widely used for the study of the existence and uniqueness of problems such Cauchy in which the operator domain is not necessarily dense. This paper presents an application of semigroups n times integrated into a problem of viscoelasticity, which is formulated as a Cauchy problem on a Banach space presents .

  7. Real-time control of tearing modes using a line-of-sight electron cyclotron emission diagnostic

    International Nuclear Information System (INIS)

    Hennen, B A; Westerhof, E; De Baar, M R; Bongers, W A; Thoen, D J; Nuij, P W J M; Steinbuch, M; Oosterbeek, J W; Buerger, A

    2010-01-01

    The stability and performance of tokamak plasmas are limited by instabilities such as neoclassical tearing modes. This paper reports on an experimental proof of principle of a feedback control approach for real-time, autonomous suppression and stabilization of tearing modes in a tokamak. The system combines an electron cyclotron emission diagnostic for sensing of the tearing modes in the same sight line with a steerable electron cyclotron resonance heating and current drive (ECRH/ECCD) antenna. A methodology for fast detection of q = m/n = 2/1 tearing modes and retrieval of their location, rotation frequency and phase is presented. Set-points to establish alignment of the ECRH/ECCD deposition location with the centre of the tearing mode are generated in real time and forwarded in closed loop to the steerable launcher and as a modulation pulse train to the gyrotron. Experimental results demonstrate the capability of the control system to track externally perturbed tearing modes in real time.

  8. Diagnostic efficacy of a real time-PCR assay for Chlamydia trachomatis infection in infertile women in north India

    Directory of Open Access Journals (Sweden)

    Benu Dhawan

    2014-01-01

    Full Text Available Background & objectives: Little is known about the prevalence of Chlamydia trachomatis infection in Indian women with infertility. To improve the diagnosis of C. trachomatis infection in developing countries, there is an urgent need to establish cost-effective molecular test with high sensitivity and specificity. This study was conducted to determine the diagnostic utility of a real time-PCR assay for detention of C. trachomatis infection in infertile women attending an infertility clinic in north India. The in house real time-PCR assay was also compared with a commercial real-time PCR based detection system. Methods: Endocervical swabs, collected from 200 infertile women were tested for C. trachomatis by three different PCR assays viz. in-house real time-PCR targeting the cryptic plasmid using published primers, along with omp1 gene and cryptic plasmid based conventional PCR assays. Specimens were also subjected to direct fluorescence assay (DFA and enzyme immunoassay (EIA Performance of in-house real time-PCR was compared with that of COBAS Taqman C. trachomatis Test, version 2.0 on all in-house real time-PCR positive sample and 30 consecutive negative samples. Results: C. trachomatis infection was found in 13.5 per cent (27/200 infertile women by in-house real time-PCR, 11.5 per cent (23/200 by cryptic plasmid and/or omp1 gene based conventional PCR, 9 per cent (18/200 by DFA and 6.5 per cent (7/200 by EIA. The in-house real time-PCR exhibited a sensitivity and specificity of 100 per cent, considering COBAS Taqman CT Test as the gold standard. The negative and positive predictive values of the in-house real time-PCR were 100 per cent. The in-house real time-PCR could detect as low as 10 copies of C. trachomatis DNA per reaction. Interpretation & conclusions: In-house real time-PCR targeting the cryptic plasmid of C. trachomatis exhibited an excellent sensitivity and specificity similar to that of COBAS Taqman CT Test, v2.0 for detection of C

  9. Diagnostic value and timing of serum antichlamidial antibody level evaluation during infertility workup among infertile women in whom tubal factor was detected with diagnostic laparoscopy

    Directory of Open Access Journals (Sweden)

    Serkan Kahyaoğlu

    2012-03-01

    Full Text Available OBJECTIVES: With normal hysterosalpingography (HSG results, selecting suitable candidates for the laparoscopic treatment of probable pelvic adhesions following previous pelvic inflammatory disease, it would be wise to investigate serum antibody screening against chlamidia trachomatis. It is worth to evaluate whether it is useful to detect a negative antichlamidial antibody disease for cancelling laparoscopy for a while with abnormal HSG findings. These two subjects have been investigated in study. MATERIAL AND METHODS: For detecting diagnostic value of serum antichlamidial antibody, in our infertility clinic, postoperative blood samples of 80 patients who were hospitalized for diagnostic laparoscopy to investigate infertility ethiology between May 2004 and November 2005 have been tested with microelisa method for antichlamidial IgM and IgG antibodies. HSG films of the patients performed at least one year were evaluated. Venous blood was drawn from these patients during postoperative early period for studying serum IgM and IgG antibodies of chlamidia trachomatis and the results were compared with operative findings. RESULTS: According to the antichlamidial antibody levels 60 (75% patients have not been infected with chlamidia and 20 (25% patients have been infected previously. When the patients were divided to two groups; normal and abnormal; based on preoperative HSG films; 18 (30% of the 60 patients with abnormal HSG films and 2 (10% of the 20 patients with normal HSG films had positive antichlamidial antibody levels respectively. CONCLUSION: The relationship between chlamidia trachomatis infection and tubal infertility has been demonstrated among 85% of patients with positive antichlamidial antibody levels and 46.7% of patients with negative levels who had tubal passage defects detected during diagnostic laparoscopy.

  10. Explicit Time Integrators for Nonlinear Dynamics Derived from the Midpoint Rule

    Directory of Open Access Journals (Sweden)

    P. Krysl

    2004-01-01

    Full Text Available We address the design of time integrators for mechanical systems that are explicit in the forcing evaluations. Our starting point is the midpoint rule, either in the classical form for the vector space setting, or in the Lie form for the rotation group. By introducing discrete, concentrated impulses we can approximate the forcing impressed upon the system over the time step, and thus arrive at first-order integrators. These can then be composed to yield a second order integrator with very desirable properties: symplecticity and momentum conservation. 

  11. A Novel Multiple-Time Scale Integrator for the Hybrid Monte Carlo Algorithm

    International Nuclear Information System (INIS)

    Kamleh, Waseem

    2011-01-01

    Hybrid Monte Carlo simulations that implement the fermion action using multiple terms are commonly used. By the nature of their formulation they involve multiple integration time scales in the evolution of the system through simulation time. These different scales are usually dealt with by the Sexton-Weingarten nested leapfrog integrator. In this scheme the choice of time scales is somewhat restricted as each time step must be an exact multiple of the next smallest scale in the sequence. A novel generalisation of the nested leapfrog integrator is introduced which allows for far greater flexibility in the choice of time scales, as each scale now must only be an exact multiple of the smallest step size.

  12. Time series analysis of the developed financial markets' integration using visibility graphs

    Science.gov (United States)

    Zhuang, Enyu; Small, Michael; Feng, Gang

    2014-09-01

    A time series representing the developed financial markets' segmentation from 1973 to 2012 is studied. The time series reveals an obvious market integration trend. To further uncover the features of this time series, we divide it into seven windows and generate seven visibility graphs. The measuring capabilities of the visibility graphs provide means to quantitatively analyze the original time series. It is found that the important historical incidents that influenced market integration coincide with variations in the measured graphical node degree. Through the measure of neighborhood span, the frequencies of the historical incidents are disclosed. Moreover, it is also found that large "cycles" and significant noise in the time series are linked to large and small communities in the generated visibility graphs. For large cycles, how historical incidents significantly affected market integration is distinguished by density and compactness of the corresponding communities.

  13. Integration of interactive three-dimensional image post-processing software into undergraduate radiology education effectively improves diagnostic skills and visual-spatial ability.

    Science.gov (United States)

    Rengier, Fabian; Häfner, Matthias F; Unterhinninghofen, Roland; Nawrotzki, Ralph; Kirsch, Joachim; Kauczor, Hans-Ulrich; Giesel, Frederik L

    2013-08-01

    Integrating interactive three-dimensional post-processing software into undergraduate radiology teaching might be a promising approach to synergistically improve both visual-spatial ability and radiological skills, thereby reducing students' deficiencies in image interpretation. The purpose of this study was to test our hypothesis that a hands-on radiology course for medical students using interactive three-dimensional image post-processing software improves radiological knowledge, diagnostic skills and visual-spatial ability. A hands-on radiology course was developed using interactive three-dimensional image post-processing software. The course consisted of seven seminars held on a weekly basis. The 25 participating fourth- and fifth-year medical students learnt to systematically analyse cross-sectional imaging data and correlated the two-dimensional images with three-dimensional reconstructions. They were instructed by experienced radiologists and collegiate tutors. The improvement in radiological knowledge, diagnostic skills and visual-spatial ability was assessed immediately before and after the course by multiple-choice tests comprising 64 questions each. Wilcoxon signed rank test for paired samples was applied. The total number of correctly answered questions improved from 36.9±4.8 to 49.5±5.4 (pability by 11.3% (psoftware into undergraduate radiology education effectively improves radiological reasoning, diagnostic skills and visual-spatial ability, and thereby even diagnostic skills for imaging modalities not included in the course. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  14. Diagnostic Usefulness of Real-Time Elastography for Liver Fibrosis in Chronic Viral Hepatitis B and C

    Directory of Open Access Journals (Sweden)

    Young Woon Kim

    2014-01-01

    Full Text Available The aim of this study was to investigate the diagnostic usefulness of real-time elastography (RTE for liver fibrosis in chronic viral hepatitis B (CHB and C (CHC. Fifty-one and thirty-two of the patients were diagnosed with CHB and CHC, respectively. Enrolled patients underwent liver biopsy and RTE. The FIB-4 index and aspartate transaminase-to-platelet ratio index (APRI were also measured. The liver fibrosis index (LFI by RTE increased significantly with the Knodell fibrosis stage: 3.14±0.62 for F0, 3.28 ± 0.42 for F1, 3.43 ± 0.53 for F3, and 4.09 ± 1.03 for F4 (P=0.000. LFI as well as APRI, FIB-4, platelet, albumin, and prothrombin time showed the difference in patients with advanced fibrosis (≥F3 and those with mild fibrosis (≤F1. In addition, RTE had better discrimination power between ≥F3 and F4 than between FIB-4 and APRI. In CHC patients, the area under receiver operating characteristic curves of RTE for advanced fibrosis was higher than that in CHB patients (0.795 versus 0.641. RTE is useful for the assessment of advanced fibrosis in patients with CHB and CHC and has better discrimination power than other serologic markers.

  15. Simultaneous detection of five different DNA targets by real-time Taqman PCR using the Roche LightCycler480: Application in viral molecular diagnostics

    NARCIS (Netherlands)

    Molenkamp, Richard; van der Ham, Alwin; Schinkel, Janke; Beld, Marcel

    2007-01-01

    One of the most interesting aspects of real-time PCR based on the detection of fluorophoric labeled oligonucleotides is the possibility of being able to detect conveniently multiple targets in the same PCR reaction. Recently, Roche Diagnostics launched a real-time PCR platform, the LightCycler480

  16. Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.

    Science.gov (United States)

    Furuta, Mayuko; Tanaka, Hiroko; Shiraishi, Yuichi; Unida, Takuro; Imamura, Michio; Fujimoto, Akihiro; Fujita, Masahi; Sasaki-Oku, Aya; Maejima, Kazuhiro; Nakano, Kaoru; Kawakami, Yoshiiku; Arihiro, Koji; Aikata, Hiroshi; Ueno, Masaki; Hayami, Shinya; Ariizumi, Shun-Ichi; Yamamoto, Masakazu; Gotoh, Kunihito; Ohdan, Hideki; Yamaue, Hiroki; Miyano, Satoru; Chayama, Kazuaki; Nakagawa, Hidewaki

    2018-05-18

    Integration of Hepatitis B virus (HBV) into the human genome can cause genetic instability, leading to selective advantages for HBV-induced liver cancer. Despite the large number of studies for HBV integration into liver cancer, little is known about the mechanism of initial HBV integration events owing to the limitations of materials and detection methods. We conducted an HBV sequence capture, followed by ultra-deep sequencing, to screen for HBV integrations in 111 liver samples from human-hepatocyte chimeric mice with HBV infection and human clinical samples containing 42 paired samples from non-tumorous and tumorous liver tissues. The HBV infection model using chimeric mice verified the efficiency of our HBV-capture analysis and demonstrated that HBV integration could occur 23 to 49 days after HBV infection via microhomology-mediated end joining and predominantly in mitochondrial DNA. Overall HBV integration sites in clinical samples were significantly enriched in regions annotated as exhibiting open chromatin, a high level of gene expression, and early replication timing in liver cells. These data indicate that HBV integration in liver tissue was biased according to chromatin accessibility, with additional selection pressures in the gene promoters of tumor samples. Moreover, an integrative analysis using paired non-tumorous and tumorous samples and HBV-related transcriptional change revealed the involvement of TERT and MLL4 in clonal selection. We also found frequent and non-tumorous liver-specific HBV integrations in FN1 and HBV-FN1 fusion transcript. Extensive survey of HBV integrations facilitates and improves the understanding of the timing and biology of HBV integration during infection and HBV-related hepatocarcinogenesis.

  17. Investigation of irradiation effects on highly integrated leading-edge electronic components of diagnostics and control systems for LHD deuterium operation

    Science.gov (United States)

    Ogawa, K.; Nishitani, T.; Isobe, M.; Murata, I.; Hatano, Y.; Matsuyama, S.; Nakanishi, H.; Mukai, K.; Sato, M.; Yokota, M.; Kobuchi, T.; Nishimura, T.; Osakabe, M.

    2017-08-01

    High-temperature and high-density plasmas are achieved by means of real-time control, fast diagnostic, and high-power heating systems. Those systems are precisely controlled via highly integrated electronic components, but can be seriously affected by radiation damage. Therefore, the effects of irradiation on currently used electronic components should be investigated for the control and measurement of Large Helical Device (LHD) deuterium plasmas. For the precise estimation of the radiation field in the LHD torus hall, the MCNP6 code is used with the cross-section library ENDF B-VI. The geometry is modeled on the computer-aided design. The dose on silicon, which is a major ingredient of electronic components, over nine years of LHD deuterium operation shows that the gamma-ray contribution is dominant. Neutron irradiation tests were performed in the OKTAVIAN at Osaka University and the Fast Neutron Laboratory at Tohoku University. Gamma-ray irradiation tests were performed at the Nagoya University Cobalt-60 irradiation facility. We found that there are ethernet connection failures of programmable logic controller (PLC) modules due to neutron irradiation with a neutron flux of 3  ×  106 cm-2 s-1. This neutron flux is equivalent to that expected at basement level in the LHD torus hall without a neutron shield. Most modules of the PLC are broken around a gamma-ray dose of 100 Gy. This is comparable with the dose in the LHD torus hall over nine years. If we consider the dose only, these components may survive more than nine years. For the safety of the LHD operation, the electronic components in the torus hall have been rearranged.

  18. Time-independent integral equation for Maxwell's system. Application of radar cross section computation

    International Nuclear Information System (INIS)

    Pujols, Agnes

    1991-01-01

    We prove that the scattering operator for the wave equation in the exterior of an non-homogeneous obstacle exists. Its distribution kernel is represented by a time-dependent boundary integral equation. A space-time integral variational formulation is developed for determining the current induced by the scattering of an electromagnetic wave by an homogeneous object. The discrete approximation of the variational problem using a finite element method in both space and time leads to stable convergent schemes, giving a numerical code for perfectly conducting cylinders. (author) [fr

  19. Monolitic integrated circuit for the strobed charge-to-time converter

    International Nuclear Information System (INIS)

    Bel'skij, V.I.; Bushnin, Yu.B.; Zimin, S.A.; Punzhin, Yu.N.; Sen'ko, V.A.; Soldatov, M.M.; Tokarchuk, V.P.

    1985-01-01

    The developed and comercially produced semiconducting circuit - gating charge-to-time converter KR1101PD1 is described. The considered integrated circuit is a short pulse charge-to-time converter with integration of input current. The circuit is designed for construction of time-to-pulse analog-to-digital converters utilized in multichannel detection systems when studying complex topology processes. Input resistance of the circuit is 0.1 Ω permissible input current is 50 mA, maximum measured charge is 300-1000 pC

  20. On the minima of the time integrated perturbation factor in the Scherer-Blume theory

    International Nuclear Information System (INIS)

    Silveira, E.F. da; Freire Junior, F.L.; Massolo, C.P.; Schaposnik, F.A.

    1981-09-01

    The minima in the correlation time dependence of the Scherer-Blume time integrated attenuation coefficients for the hyperfine perturbation of ions recoiling in gas are studied. Its position and depth are determined for different physical situations and comparison with experimental data is shown. (Author) [pt

  1. Creating a Campus Culture of Integrity: Comparing the Perspectives of Full- and Part-Time Faculty

    Science.gov (United States)

    Hudd, Suzanne S.; Apgar, Caroline; Bronson, Eric Franklyn; Lee, Renee Gravois

    2009-01-01

    Part-time faculty play an important role in creating a culture of integrity on campus, yet they face a number of structural constraints. This paper seeks to improve our understanding of the potentially unique experiences of part-time faculty with academic misconduct and suggests ways to more effectively involve them in campus-wide academic…

  2. An Integrated Theory of Prospective Time Interval Estimation: The Role of Cognition, Attention, and Learning

    Science.gov (United States)

    Taatgen, Niels A.; van Rijn, Hedderik; Anderson, John

    2007-01-01

    A theory of prospective time perception is introduced and incorporated as a module in an integrated theory of cognition, thereby extending existing theories and allowing predictions about attention and learning. First, a time perception module is established by fitting existing datasets (interval estimation and bisection and impact of secondary…

  3. An integrated theory of prospective time interval estimation : The role of cognition, attention, and learning

    NARCIS (Netherlands)

    Taatgen, Niels A.; van Rijn, Hedderik; Anderson, John

    A theory of prospective time perception is introduced and incorporated as a module in an integrated theory of cognition, thereby extending existing theories and allowing predictions about attention and learning. First, a time perception module is established by fitting existing datasets (interval

  4. Development of a precise long-time digital integrator for magnetic measurements in a tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Kurihara, Kenichi; Kawamata, Youichi [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    1997-10-01

    Long-time D-T burning operation in a tokamak requires that a magnetic sensor must work in an environment of 14-MeV intense neutron field, and that the measurement system must output precise magnetic field values. A method of time-integration of voltage produced in a simple pick-up coil seems to have preferable features of good time response, easy maintenance, and resistance to neutron irradiation. However, an inevitably-produced signal drift makes it difficult to apply the method to the long-time integral operation. To solve this problem, we have developed a new digital integrator (a voltage-to-frequency converter and an up-down counter) with testing the trial boards in the JT-60 magnetic measurements. This reports all of the problems and their measures through the development steps in details, and shows how to apply this method to the ITER operation. (author)

  5. Connection between Feynman integrals having different values of the space-time dimension

    International Nuclear Information System (INIS)

    Tarasov, O.V.

    1996-05-01

    A systematic algorithm for obtaining recurrence relations for dimensionally regularized Feynman integrals w.r.t. the space-time dimension d is proposed. The relation between d and d-2 dimensional integrals is given in terms of a differential operator for which an explicit formula can be obtained for each Feynman diagram. We show how the method works for one-, two- and three-loop integrals. The new recurrence relations w.r.t. d are complementary to the recurrence relations which derive from the method of integration by parts. We find that the problem of the irreducible numerators in Feynman integrals can be naturally solved in the framework of the proposed generalized recurrence relations. (orig.)

  6. Evidence-Centered Design for Diagnostic Assessment within Digital Learning Environments: Integrating Modern Psychometrics and Educational Data Mining

    Science.gov (United States)

    Rupp, André A.; Nugent, Rebecca; Nelson, Brian

    2012-01-01

    In recent years the educational community has increasingly embraced digital technologies for the purposes of developing alternative learning environments, providing diagnostic feedback, and fostering the development of so-called 21st-century skills. This special issue is dedicated to bridging recent work from the disciplines of educational and…

  7. Integrating Research-Informed Teaching within an Undergraduate Level 4 (Year 1) Diagnostic Radiography Curriculum: A Pilot Study

    Science.gov (United States)

    Higgins, Robert; Hogg, Peter; Robinson, Leslie

    2013-01-01

    This article discusses the piloting and evaluation of the Research-informed Teaching experience (RiTe) project. The aim of RiTe was to link teaching and learning with research within an undergraduate diagnostic radiography curriculum. A preliminary pilot study of RiTe was undertaken with a group of level 4 (year 1) volunteer BSc (Hons) diagnostic…

  8. Effect of time lapse on the diagnostic accuracy of cone beam computed tomography for detection of vertical root fractures

    Energy Technology Data Exchange (ETDEWEB)

    Eskandarloo, Amir; Shokri, Abbas, E-mail: Dr.a.shokri@gmail.com [Dental Research Center, Department of Oral and Maxillofacial Radiology, Hamadan University of Medical Sciences, Hamadan (Iran, Islamic Republic of); Asl, Amin Mahdavi [Department of Oral and Maxillofacial Radiology, Golestan University of Medical Sciences, Gorgan (Iran, Islamic Republic of); Jalalzadeh, Mohsen [Department of Endodontics, Hamadan University of Medical Sciences, Hamadan (Iran, Islamic Republic of); Tayari, Maryam [Department of Pedodontics, Golestan University of Medical Sciences, Gorgan (Iran, Islamic Republic of); Hosseinipanah, Mohammad [Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan (Iran, Islamic Republic of); Fardmal, Javad [Research Center for Health Sciences and Department of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan (Iran, Islamic Republic of)

    2016-01-15

    Accurate and early diagnosis of vertical root fractures (VRFs) is imperative to prevent extensive bone loss and unnecessary endodontic and prosthodontic treatments. The aim of this study was to assess the effect of time lapse on the diagnostic accuracy of cone beam computed tomography (CBCT) for VRFs in endodontically treated dog’s teeth. Forty eight incisors and premolars of three adult male dogs underwent root canal therapy. The teeth were assigned to two groups: VRFs were artificially induced in the first group (n=24) while the teeth in the second group remained intact (n=24). The CBCT scans were obtained by NewTom 3G unit immediately after inducing VRFs and after one, two, three, four, eight, 12 and 16 weeks. Three oral and maxillofacial radiologists blinded to the date of radiographs assessed the presence/absence of VRFs on CBCT scans. The sensitivity, specificity and accuracy values were calculated and data were analyzed using SPSS v.16 software and ANOVA. The total accuracy of detection of VRFs immediately after surgery, one, two, three, four, eight, 12 and 16 weeks was 67.3%, 68.7%, 66.6%, 64.6%, 64.5%, 69.4%, 68.7%, 68% respectively. The effect of time lapse on detection of VRFs was not significant (p>0.05). Overall sensitivity, specificity and accuracy of CBCT for detection of VRFs were 74.3%, 62.2%, 67.2% respectively. Cone beam computed tomography is a valuable tool for detection of VRFs. Time lapse (four months) had no effect on detection of VRFs on CBCT scans. (author)

  9. Effect of time lapse on the diagnostic accuracy of cone beam computed tomography for detection of vertical root fractures

    International Nuclear Information System (INIS)

    Eskandarloo, Amir; Shokri, Abbas; Asl, Amin Mahdavi; Jalalzadeh, Mohsen; Tayari, Maryam; Hosseinipanah, Mohammad; Fardmal, Javad

    2016-01-01

    Accurate and early diagnosis of vertical root fractures (VRFs) is imperative to prevent extensive bone loss and unnecessary endodontic and prosthodontic treatments. The aim of this study was to assess the effect of time lapse on the diagnostic accuracy of cone beam computed tomography (CBCT) for VRFs in endodontically treated dog’s teeth. Forty eight incisors and premolars of three adult male dogs underwent root canal therapy. The teeth were assigned to two groups: VRFs were artificially induced in the first group (n=24) while the teeth in the second group remained intact (n=24). The CBCT scans were obtained by NewTom 3G unit immediately after inducing VRFs and after one, two, three, four, eight, 12 and 16 weeks. Three oral and maxillofacial radiologists blinded to the date of radiographs assessed the presence/absence of VRFs on CBCT scans. The sensitivity, specificity and accuracy values were calculated and data were analyzed using SPSS v.16 software and ANOVA. The total accuracy of detection of VRFs immediately after surgery, one, two, three, four, eight, 12 and 16 weeks was 67.3%, 68.7%, 66.6%, 64.6%, 64.5%, 69.4%, 68.7%, 68% respectively. The effect of time lapse on detection of VRFs was not significant (p>0.05). Overall sensitivity, specificity and accuracy of CBCT for detection of VRFs were 74.3%, 62.2%, 67.2% respectively. Cone beam computed tomography is a valuable tool for detection of VRFs. Time lapse (four months) had no effect on detection of VRFs on CBCT scans. (author)

  10. Autonomous Diagnostic Imaging Performed by Untrained Operator Using Augmented Reality as a Form of "Just-in-Time" Training

    Science.gov (United States)

    Martin, David S.; Wang, Lui; Laurie, Steven S.; Lee, Stuart M. C.; Stenger, Michael B.

    2017-01-01

    We will address the Human Factors and Performance Team, "Risk of performance errors due to training deficiencies" by improving the JIT training materials for ultrasound and OCT imaging by providing advanced guidance in a detailed, timely, and user-friendly manner. Specifically, we will (1) develop an audio-visual tutorial using AR that guides non-experts through an abdominal trauma ultrasound protocol; (2) develop an audio-visual tutorial using AR to guide an untrained operator through the acquisition of OCT images; (3) evaluate the quality of abdominal ultrasound and OCT images acquired by untrained operators using AR guidance compared to images acquired using traditional JIT techniques (laptop-based training conducted before image acquisition); and (4) compare the time required to complete imaging studies using AR tutorials with images acquired using current JIT practices to identify areas for time efficiency improvements. Two groups of subjects will be recruited to participate in this study. Operator-subjects, without previous experience in ultrasound or OCT, will be asked to perform both procedures using either the JIT training with AR technology or the traditional JIT training via laptop. Images acquired by inexperienced operator-subjects will be scored by experts in that imaging modality for diagnostic and research quality; experts will be blinded to the form of JIT used to acquire the images. Operator-subjects also will be asked to submit feedback to improve the training modules used during the scans to improve future training modules. Scanned-subjects will be a small group individuals from whom all images will be acquired.

  11. Autonomous Diagnostic Imaging Performed by Untrained Operators using Augmented Reality as a Form of "Just-in-Time" Training

    Science.gov (United States)

    Martin, D. S.; Wang, L.; Laurie, S. S.; Lee, S. M. C.; Fleischer, A. C.; Gibson, C. R.; Stenger, M. B.

    2017-01-01

    We will address the Human Factors and Performance Team, "Risk of performance errors due to training deficiencies" by improving the JIT training materials for ultrasound and OCT imaging by providing advanced guidance in a detailed, timely, and user-friendly manner. Specifically, we will (1) develop an audio-visual tutorial using AR that guides non-experts through an abdominal trauma ultrasound protocol; (2) develop an audio-visual tutorial using AR to guide an untrained operator through the acquisition of OCT images; (3) evaluate the quality of abdominal ultrasound and OCT images acquired by untrained operators using AR guidance compared to images acquired using traditional JIT techniques (laptop-based training conducted before image acquisition); and (4) compare the time required to complete imaging studies using AR tutorials with images acquired using current JIT practices to identify areas for time efficiency improvements. Two groups of subjects will be recruited to participate in this study. Operator-subjects, without previous experience in ultrasound or OCT, will be asked to perform both procedures using either the JIT training with AR technology or the traditional JIT training via laptop. Images acquired by inexperienced operator-subjects will be scored by experts in that imaging modality for diagnostic and research quality; experts will be blinded to the form of JIT used to acquire the images. Operator-subjects also will be asked to submit feedback to improve the training modules used during the scans to improve future training modules. Scanned-subjects will be a small group individuals from whom all images will be acquired.

  12. [Special application of matrix-assisted laser desorption ionization time-of-flight mass spectrometry in clinical microbiological diagnostics].

    Science.gov (United States)

    Nagy, Erzsébet; Abrók, Marianna; Bartha, Noémi; Bereczki, László; Juhász, Emese; Kardos, Gábor; Kristóf, Katalin; Miszti, Cecilia; Urbán, Edit

    2014-09-21

    Matrix-assisted laser desorption ionization time-of-flight mass spectrometry as a new possibility for rapid identification of bacteria and fungi revolutionized the clinical microbiological diagnostics. It has an extreme importance in the routine microbiological laboratories, as identification of the pathogenic species rapidly will influence antibiotic selection before the final determination of antibiotic resistance of the isolate. The classical methods for identification of bacteria or fungi, based on biochemical tests, are influenced by many environmental factors. The matrix-assisted laser desorption ionization time-of-flight mass spectrometry is a rapid method which is able to identify a great variety of the isolated bacteria and fungi based on the composition of conserved ribosomal proteins. Recently several other applications of the method have also been investigated such as direct identification of pathogens from the positive blood cultures. There are possibilities to identify bacteria from the urine samples in urinary tract infection or from other sterile body fluids. Using selective enrichment broth Salmonella sp from the stool samples can be identified more rapidly, too. The extended spectrum beta-lactamase or carbapenemase production of the isolated bacteria can be also detected by this method helping the antibiotic selection in some cases. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry based methods are suitable to investigate changes in deoxyribonucleic acid or ribonucleic acid, to carry out rapid antibiotic resistance determination or other proteomic analysis. The aim of this paper is to give an overview about present possibilities of using this technique in the clinical microbiological routine procedures.

  13. On the internal resonant modes in marching-on-in-time solution of the time domain electric field integral equation

    KAUST Repository

    Shi, Yifei

    2013-08-01

    Internal resonant modes are always observed in the marching-on-in-time (MOT) solution of the time domain electric field integral equation (EFIE), although \\'relaxed initial conditions,\\' which are enforced at the beginning of time marching, should in theory prevent these spurious modes from appearing. It has been conjectured that, numerical errors built up during time marching establish the necessary initial conditions and induce the internal resonant modes. However, this conjecture has never been proved by systematic numerical experiments. Our numerical results in this communication demonstrate that, the internal resonant modes\\' amplitudes are indeed dictated by the numerical errors. Additionally, it is shown that in a few cases, the internal resonant modes can be made \\'invisible\\' by significantly suppressing the numerical errors. These tests prove the conjecture that the internal resonant modes are induced by numerical errors when the time domain EFIE is solved by the MOT method. © 2013 IEEE.

  14. On the internal resonant modes in marching-on-in-time solution of the time domain electric field integral equation

    KAUST Repository

    Shi, Yifei; Bagci, Hakan; Lu, Mingyu

    2013-01-01

    Internal resonant modes are always observed in the marching-on-in-time (MOT) solution of the time domain electric field integral equation (EFIE), although 'relaxed initial conditions,' which are enforced at the beginning of time marching, should in theory prevent these spurious modes from appearing. It has been conjectured that, numerical errors built up during time marching establish the necessary initial conditions and induce the internal resonant modes. However, this conjecture has never been proved by systematic numerical experiments. Our numerical results in this communication demonstrate that, the internal resonant modes' amplitudes are indeed dictated by the numerical errors. Additionally, it is shown that in a few cases, the internal resonant modes can be made 'invisible' by significantly suppressing the numerical errors. These tests prove the conjecture that the internal resonant modes are induced by numerical errors when the time domain EFIE is solved by the MOT method. © 2013 IEEE.

  15. Demonstration of a time-integrated short line of sight neutron imaging system for inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, R., E-mail: raspberry@lanl.gov; Danly, C.; Fatherley, V. E.; Merrill, F. E.; Volegov, P.; Wilde, C. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Christensen, K.; Fittinghoff, D.; Grim, G. P.; Izumi, N.; Jedlovec, D.; Skulina, K. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    2015-12-15

    The Neutron Imaging System (NIS) is an important diagnostic for understanding implosions of deuterium-tritium capsules at the National Ignition Facility. While the detectors for the existing system must be positioned 28 m from the source to produce sufficient imaging magnification and resolution, recent testing of a new short line of sight neutron imaging system has shown sufficient resolution to allow reconstruction of the source image with quality similar to that of the existing NIS on a 11.6 m line of sight. The new system used the existing pinhole aperture array and a stack of detectors composed of 2 mm thick high-density polyethylene converter material followed by an image plate. In these detectors, neutrons enter the converter material and interact with protons, which recoil and deposit energy within the thin active layer of the image plate through ionization losses. The described system produces time-integrated images for all neutron energies passing through the pinhole. We present details of the measurement scheme for this novel technique to produce energy-integrated neutron images as well as source reconstruction results from recent experiments at NIF.

  16. Integration of interactive three-dimensional image post-processing software into undergraduate radiology education effectively improves diagnostic skills and visual-spatial ability

    Energy Technology Data Exchange (ETDEWEB)

    Rengier, Fabian, E-mail: fabian.rengier@web.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg (Germany); Häfner, Matthias F. [University Hospital Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg (Germany); Unterhinninghofen, Roland [Karlsruhe Institute of Technology (KIT), Institute for Anthropomatics, Department of Informatics, Adenauerring 2, 76131 Karlsruhe (Germany); Nawrotzki, Ralph; Kirsch, Joachim [University of Heidelberg, Institute of Anatomy and Cell Biology, Im Neuenheimer Feld 307, 69120 Heidelberg (Germany); Kauczor, Hans-Ulrich [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg (Germany); Giesel, Frederik L. [University of Heidelberg, Institute of Anatomy and Cell Biology, Im Neuenheimer Feld 307, 69120 Heidelberg (Germany); University Hospital Heidelberg, Department of Nuclear Medicine, Im Neuenheimer Feld 400, 69120 Heidelberg (Germany)

    2013-08-15

    Purpose: Integrating interactive three-dimensional post-processing software into undergraduate radiology teaching might be a promising approach to synergistically improve both visual-spatial ability and radiological skills, thereby reducing students’ deficiencies in image interpretation. The purpose of this study was to test our hypothesis that a hands-on radiology course for medical students using interactive three-dimensional image post-processing software improves radiological knowledge, diagnostic skills and visual-spatial ability. Materials and methods: A hands-on radiology course was developed using interactive three-dimensional image post-processing software. The course consisted of seven seminars held on a weekly basis. The 25 participating fourth- and fifth-year medical students learnt to systematically analyse cross-sectional imaging data and correlated the two-dimensional images with three-dimensional reconstructions. They were instructed by experienced radiologists and collegiate tutors. The improvement in radiological knowledge, diagnostic skills and visual-spatial ability was assessed immediately before and after the course by multiple-choice tests comprising 64 questions each. Wilcoxon signed rank test for paired samples was applied. Results: The total number of correctly answered questions improved from 36.9 ± 4.8 to 49.5 ± 5.4 (p < 0.001) which corresponded to a mean improvement of 12.6 (95% confidence interval 9.9–15.3) or 19.8%. Radiological knowledge improved by 36.0% (p < 0.001), diagnostic skills for cross-sectional imaging by 38.7% (p < 0.001), diagnostic skills for other imaging modalities – which were not included in the course – by 14.0% (p = 0.001), and visual-spatial ability by 11.3% (p < 0.001). Conclusion: The integration of interactive three-dimensional image post-processing software into undergraduate radiology education effectively improves radiological reasoning, diagnostic skills and visual-spatial ability, and thereby

  17. Integration of interactive three-dimensional image post-processing software into undergraduate radiology education effectively improves diagnostic skills and visual-spatial ability

    International Nuclear Information System (INIS)

    Rengier, Fabian; Häfner, Matthias F.; Unterhinninghofen, Roland; Nawrotzki, Ralph; Kirsch, Joachim; Kauczor, Hans-Ulrich; Giesel, Frederik L.

    2013-01-01

    Purpose: Integrating interactive three-dimensional post-processing software into undergraduate radiology teaching might be a promising approach to synergistically improve both visual-spatial ability and radiological skills, thereby reducing students’ deficiencies in image interpretation. The purpose of this study was to test our hypothesis that a hands-on radiology course for medical students using interactive three-dimensional image post-processing software improves radiological knowledge, diagnostic skills and visual-spatial ability. Materials and methods: A hands-on radiology course was developed using interactive three-dimensional image post-processing software. The course consisted of seven seminars held on a weekly basis. The 25 participating fourth- and fifth-year medical students learnt to systematically analyse cross-sectional imaging data and correlated the two-dimensional images with three-dimensional reconstructions. They were instructed by experienced radiologists and collegiate tutors. The improvement in radiological knowledge, diagnostic skills and visual-spatial ability was assessed immediately before and after the course by multiple-choice tests comprising 64 questions each. Wilcoxon signed rank test for paired samples was applied. Results: The total number of correctly answered questions improved from 36.9 ± 4.8 to 49.5 ± 5.4 (p < 0.001) which corresponded to a mean improvement of 12.6 (95% confidence interval 9.9–15.3) or 19.8%. Radiological knowledge improved by 36.0% (p < 0.001), diagnostic skills for cross-sectional imaging by 38.7% (p < 0.001), diagnostic skills for other imaging modalities – which were not included in the course – by 14.0% (p = 0.001), and visual-spatial ability by 11.3% (p < 0.001). Conclusion: The integration of interactive three-dimensional image post-processing software into undergraduate radiology education effectively improves radiological reasoning, diagnostic skills and visual-spatial ability, and thereby

  18. Ages and transit times as important diagnostics of model performance for predicting carbon dynamics in terrestrial vegetation models

    Science.gov (United States)

    Ceballos-Núñez, Verónika; Richardson, Andrew D.; Sierra, Carlos A.

    2018-03-01

    The global carbon cycle is strongly controlled by the source/sink strength of vegetation as well as the capacity of terrestrial ecosystems to retain this carbon. These dynamics, as well as processes such as the mixing of old and newly fixed carbon, have been studied using ecosystem models, but different assumptions regarding the carbon allocation strategies and other model structures may result in highly divergent model predictions. We assessed the influence of three different carbon allocation schemes on the C cycling in vegetation. First, we described each model with a set of ordinary differential equations. Second, we used published measurements of ecosystem C compartments from the Harvard Forest Environmental Measurement Site to find suitable parameters for the different model structures. And third, we calculated C stocks, release fluxes, radiocarbon values (based on the bomb spike), ages, and transit times. We obtained model simulations in accordance with the available data, but the time series of C in foliage and wood need to be complemented with other ecosystem compartments in order to reduce the high parameter collinearity that we observed, and reduce model equifinality. Although the simulated C stocks in ecosystem compartments were similar, the different model structures resulted in very different predictions of age and transit time distributions. In particular, the inclusion of two storage compartments resulted in the prediction of a system mean age that was 12-20 years older than in the models with one or no storage compartments. The age of carbon in the wood compartment of this model was also distributed towards older ages, whereas fast cycling compartments had an age distribution that did not exceed 5 years. As expected, models with C distributed towards older ages also had longer transit times. These results suggest that ages and transit times, which can be indirectly measured using isotope tracers, serve as important diagnostics of model structure

  19. Optimal order and time-step criterion for Aarseth-type N-body integrators

    International Nuclear Information System (INIS)

    Makino, Junichiro

    1991-01-01

    How the selection of the time-step criterion and the order of the integrator change the efficiency of Aarseth-type N-body integrators is discussed. An alternative to Aarseth's scheme based on the direct calculation of the time derivative of the force using the Hermite interpolation is compared to Aarseth's scheme, which uses the Newton interpolation to construct the predictor and corrector. How the number of particles in the system changes the behavior of integrators is examined. The Hermite scheme allows a time step twice as large as that for the standard Aarseth scheme for the same accuracy. The calculation cost of the Hermite scheme per time step is roughly twice as much as that of the standard Aarseth scheme. The optimal order of the integrators depends on both the particle number and the accuracy required. The time-step criterion of the standard Aarseth scheme is found to be inapplicable to higher-order integrators, and a more uniformly reliable criterion is proposed. 18 refs

  20. Energy Payback Time Calculation for a Building Integrated Semitransparent Thermal (BISPVT) System with Air Duct

    OpenAIRE

    Kanchan Mudgil; Deepali Kamthania

    2013-01-01

    This paper evaluates the energy payback time (EPBT) of building integrated photovoltaic thermal (BISPVT) system for Srinagar, India. Three different photovoltaic (PV) modules namely mono crystalline silicon (m-Si), poly crystalline silicon (p-Si), and amorphous silicon (a-Si) have been considered for calculation of EPBT. It is found that, the EPBT is lowest in m-Si. Hence, integration of m-Si PV modules on the roof of a room is economical.