WorldWideScience

Sample records for diagnostic instrument-based controls

  1. Target Diagnostic Instrument-Based Controls Framework for the National Ignition Facility (NIF)

    Energy Technology Data Exchange (ETDEWEB)

    Shelton, R T; O' Brien, D W; Kamperschroer, J H; Nelson, J R

    2007-10-03

    The extreme physics of targets shocked by NIF's 192-beam laser are observed by a diverse suite of diagnostics including optical backscatter, time-integrated and gated X-ray sensors, and laser velocity interferometry. Diagnostics to diagnose fusion ignition implosion and neutron emissions are being planned. Many diagnostics will be developed by collaborators at other sites, but ad hoc controls could lead to unreliable and costly operations. An instrument-based controls (I-BC) framework for both hardware and software facilitates development and eases integration. Each complex diagnostic typically uses an ensemble of electronic instruments attached to sensors, digitizers, cameras, and other devices. In the I-BC architecture each instrument is interfaced to a low-cost Windows XP processor and Java application. Each instrument is aggregated with others as needed in the supervisory system to form an integrated diagnostic. The Java framework provides data management, control services and operator GUI generation. I-BCs are reusable by replication and reconfiguration for specific diagnostics in XML. Advantages include minimal application code, easy testing, and better reliability. Collaborators save costs by assembling diagnostics with existing I-BCs. This paper discusses target diagnostic instrumentation used on NIF and presents the I-BC architecture and framework.

  2. Diagnostics for Hypersonic Engine Control

    Science.gov (United States)

    2015-02-01

    AFRL-RQ-WP-TR-2015-0037 DIAGNOSTICS FOR HYPERSONIC ENGINE CONTROL Michael S. Brown and Jeffrey M. Donbar Hypersonic Sciences Branch...DD-MM-YY) 2. REPORT TYPE 3. DATES COVERED (From - To) February 2015 Interim 01 March 2013 – 24 February 2015 4. TITLE AND SUBTITLE DIAGNOSTICS FOR...SUPPLEMENTARY NOTES PA Case Number: 88ABW-2015-0636; Clearance Date: 23 Feb 2015. 14. ABSTRACT The overall goal of the research is to find diagnostic

  3. DEMO diagnostics and burn control

    Energy Technology Data Exchange (ETDEWEB)

    Biel, Wolfgang, E-mail: w.biel@fz-juelich.de [Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich (Germany); Department of Applied Physics, Ghent University (Belgium); Baar, Marco de [FOM-Institute DIFFER, Nieuwegein (Netherlands); Eindhoven University of Technology (Netherlands); Dinklage, Andreas [Max-Planck-Institut für Plasmaphysik, Greifswald (Germany); Felici, Federico [Eindhoven University of Technology (Netherlands); König, Ralf [Max-Planck-Institut für Plasmaphysik, Greifswald (Germany); Meister, Hans; Treutterer, Wolfgang [Max-Planck-Institut für Plasmaphysik, Garching (Germany); Wenninger, Ronald [Max-Planck-Institut für Plasmaphysik, Garching (Germany); EFDA Power Plant Physics and Technology, Garching (Germany)

    2015-10-15

    Highlights: • An initial concept for the DEMO diagnostic and control system is presented. • A preliminary list of control functions and candidate diagnostics is developed. • Challenges regarding disruptions, power exhaust and radiation control are highlighted. • The need for introducing realistic control margins is emphasized. • On outline of the future R&D plan is presented. - Abstract: The development of the control system for a tokamak demonstration fusion reactor (DEMO) faces unprecedented challenges. First, the requirements for control reliability and accuracy are more stringent than on existing fusion devices: any loss of plasma control on DEMO may result in a disruption which could damage the inner wall of the machine, while operating the device with larger margins against the operational limits would lead to a reduction of the electrical output power. Second, the performance of DEMO control is limited by space restrictions for the implementation of components (optimization of the tritium breeding rate), by lifetime issues for the front-end parts (neutron and gamma radiation, erosion and deposition acting on all components) and by slow, weak and indirect action of the available actuators (plasma shaping, heating and fuelling). The European DEMO conceptual design studies include the development of a reliable control system, since the details of the achievable plasma scenario and the machine design may depend on the actual performance of the control system. In the first phase of development, an initial understanding of the prime choices of diagnostic methods applicable to DEMO, implementation and performance issues, the interrelation with the plasma scenario definition, and the planning of necessary future R&D have been obtained.

  4. 步进电机式汽车电子仪表的装针过程设计与控制%Process Design and Control of Pointer Installation of Auto Electronic Instrument Based on Stepper Motor

    Institute of Scientific and Technical Information of China (English)

    张彦平

    2012-01-01

    对步进电机式电子仪表的工作过程进行简要介绍,详细阐述其装针过程设计与控制。%The author briefly introduces the working process of electronic instrument based on stepper motor, elaborates the process design and control of its pointer installation.

  5. Diagnostic randomized controlled trials: the final frontier.

    Science.gov (United States)

    Rodger, Marc; Ramsay, Tim; Fergusson, Dean

    2012-08-16

    Clinicians, patients, governments, third-party payers, and the public take for granted that diagnostic tests are accurate, safe and effective. However, we may be seriously misled if we are relying on robust study design to ensure accurate, safe, and effective diagnostic tests. Properly conducted, randomized controlled trials are the gold standard for assessing the effectiveness and safety of interventions, yet are rarely conducted in the assessment of diagnostic tests. Instead, diagnostic cohort studies are commonly performed to assess the characteristics of a diagnostic test including sensitivity and specificity. While diagnostic cohort studies can inform us about the relative accuracy of an experimental diagnostic intervention compared to a reference standard, they do not inform us about whether the differences in accuracy are clinically important, or the degree of clinical importance (in other words, the impact on patient outcomes). In this commentary we provide the advantages of the diagnostic randomized controlled trial and suggest a greater awareness and uptake in their conduct. Doing so will better ensure that patients are offered diagnostic procedures that will make a clinical difference.

  6. Diagnostic, reliablility and control systems

    CERN Document Server

    Leondes

    2014-01-01

    1. Explicit-Model-Based Fault Detection Method in Industrial Plants 2. Soft Sensor: An Effective Approach to Improve Control 3. Techniques in Soft Computing and Their Utilization in Mechatronic Products 4. Techniques in the Control of Interconnected Plants 5. A Mechatronic Systems Approach to Controlling Robotic Systems with Actuator Dynamics 6. Process and Control Design for Fast Coordinate Measuring Machines 7. Techniques in the Stability of Mechatronic Systems with Sensor or Actuator Failure.

  7. DEMO diagnostics and burn control

    NARCIS (Netherlands)

    Biel, W.; de M. Baar,; Dinklage, A.; Felici, F.; Konig, R.; Meister, H.; Treutterer, W.; Wenninger, R.

    2015-01-01

    The development of the control system for a tokamak demonstration fusion reactor (DEMO) faces unprecedented challenges. First, the requirements for control reliability and accuracy are more stringent than on existing fusion devices: any loss of plasma control on DEMO may result in a disruption which

  8. DEMO diagnostics and burn control

    NARCIS (Netherlands)

    Biel, W.; de M. Baar,; Dinklage, A.; Felici, F.; Konig, R.; Meister, H.; Treutterer, W.; Wenninger, R.

    2015-01-01

    The development of the control system for a tokamak demonstration fusion reactor (DEMO) faces unprecedented challenges. First, the requirements for control reliability and accuracy are more stringent than on existing fusion devices: any loss of plasma control on DEMO may result in a disruption which

  9. Exhaust emission control and diagnostics

    Science.gov (United States)

    Mazur, Christopher John; Upadhyay, Devesh

    2006-11-14

    A diesel engine emission control system uses an upstream oxidation catalyst and a downstream SCR catalyst to reduce NOx in a lean exhaust gas environment. The engine and upstream oxidation catalyst are configured to provide approximately a 1:1 ratio of NO to NO2 entering the downstream catalyst. In this way, the downstream catalyst is insensitive to sulfur contamination, and also has improved overall catalyst NOx conversion efficiency. Degradation of the system is determined when the ratio provided is no longer near the desired 1:1 ratio. This condition is detected using measurements of engine operating conditions such as from a NOx sensor located downstream of the catalysts. Finally, control action to adjust an injected amount of reductant in the exhaust gas based on the actual NO to NO2 ratio upstream of the SCR catalyst and downstream of the oxidation catalyst.

  10. ISTTOK plasma control with the tomography diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, H.; Caralho, P.J.; Duarte, P.; Pereira, T.; Coelho, R.; Silva, C. [Association Euratom/IST, Institute of Plasmas and Nuclear Fusion, Technology Graduate Institute, P-1049-001 Lisbon (Portugal)

    2011-07-01

    A real-time plasma position control system is mandatory to achieve long duration (up to 250 ms), Alternating Current (AC) discharges on the ISTTOK tokamak. Such a system has been used for some time supported only on magnetic field diagnostic data. However, this system does not function accurately when the plasma current is low, rendering it inoperative during the plasma current reversal. A tomography diagnostic with 3 pinhole cameras and 8 silicone photodiode channels per camera was installed and customized to supply alternative plasma position to be used for plasma position control. As no filtering is applied, most of the radiation detected is in the visible/near-UV range. This system (i) executes a tomographic reconstruction, (ii) determines the average emissivity position from it, (iii) calculates the shift from the required position and (iv) supplies the vertical field power supply unit with the desired current value, all in less than 100 {mu}s. The horizontal magnetic field power supply unit is expected to be included in the system and will have no impact in the process time. This paper presents the tomography diagnostic architecture together with results of its scientific exploitation in ISTTOK AC discharges, where it has proven to be capable of supplying an accurate plasma position during the current reversal. The use of the tomography diagnostic for plasma position overcomes some limitations of the magnetic diagnostics, but poses challenges of its own such as blindness to plasma current direction. (authors)

  11. Control and Diagnostic Model of Brushless Dc Motor

    Science.gov (United States)

    Abramov, Ivan V.; Nikitin, Yury R.; Abramov, Andrei I.; Sosnovich, Ella V.; Božek, Pavol

    2014-09-01

    A simulation model of brushless DC motor (BLDC) control and diagnostics is considered. The model has been developed using a freeware complex "Modeling in technical devices". Faults and diagnostic parameters of BLDC are analyzed. A logicallinguistic diagnostic model of BLDC has been developed on basis of fuzzy logic. The calculated rules determine dependence of technical condition on diagnostic parameters, their trends and utilized lifetime of BLDC. Experimental results of BLDC technical condition diagnostics are discussed. It is shown that in the course of BLDC degradation the motor condition change depends on diagnostic parameter values

  12. System control module diagnostic Expert Assistant

    Science.gov (United States)

    Flores, Luis M.; Hansen, Roger F.

    1990-01-01

    The Orbiter EXperiments (OEX) Program was established by NASA's Office of Aeronautics and Space Technology (OAST) to accomplish the precise data collection necessary to support a complete and accurate assessment of Space Transportation System (STS) Orbiter performance during all phases of a mission. During a mission, data generated by the various experiments are conveyed to the OEX System Control Module (SCM) which arranges for and monitors storage of the data on the OEX tape recorder. The SCM Diagnostic Expert Assistant (DEA) is an expert system which provides on demand advice to technicians performing repairs of a malfunctioning SCM. The DEA is a self-contained, data-driven knowledge-based system written in the 'C' Language Production System (CLIPS) for a portable micro-computer of the IBM PC/XT class. The DEA reasons about SCM hardware faults at multiple levels; the most detailed layer of encoded knowledge of the SCM is a representation of individual components and layouts of the custom-designed component boards.

  13. Atmospheric Pressure Plasma Based Flame Control and Diagnostics

    Science.gov (United States)

    2015-01-01

    TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Atmospheric Pressure Plasma Based Flame Control and Diagnostics 5a...to 10%)  Flame speed enhancement (>20%)  Extension of lean limit (factor of two)  Distributed ignition  Development of new diagnostics

  14. Quality control for diagnostic oral microbiology laboratories in European countries

    NARCIS (Netherlands)

    Rautemaa-Richardson, R.; van der Reijden, W.A.; Dahlen, G.; Smith, A.J.

    2011-01-01

    Participation in diagnostic microbiology internal and external quality control (QC) processes is good laboratory practice and an essential component of a quality management system. However, no QC scheme for diagnostic oral microbiology existed until 2009 when the Clinical Oral Microbiology (COMB)

  15. Territorial fiscal control. Diagnostic and outlook

    Directory of Open Access Journals (Sweden)

    Carlos Ariel Sanchez-Torres

    2010-03-01

    Full Text Available This document contains the research results of the territorial fiscal control improvement proposal project, developed  by  Rosario  University  with  the support by  the  German Technical Cooperation Agency (GTZ. In short, it analyzes and identifies the principal problems of the Colombian territorial fiscal control system on the first level, (Contraloría General de la República Office, Departmental, Municipal and District Controller Offices offering a general view of the performance and the distribution of responsibilities between the different fiscal control bodies. The document is structured as follows: l introduction and constitutional scheme of the fiscal control system, 2 a description of the distribution of responsibilities between the different fiscal control bodies, 3 the development of territorial fiscal control with reference to jurisprudence,  4 territorial fiscal control, 5 quality of territorial fiscal control and 6 reform proposals and conclusions. Among the proposals  analyzed  in this  project  we  have,  the depoliticization  on  the election of the employees in charge of territorial fiscal control, the financing necessary to realize that control, sourced from territorial entities own resources and the achievement of economies of scale thought the merging of control bodies; Another proposal involves the integration of territorial fiscal control with the second level control by means of .the application of support mechanism to the control function exercise by Contraloría General de la República Office, and a improvement of information systems, indicators and evaluations applied by territorial controller offices.

  16. Diagnostics for Intelligent Control of MPD Engines

    Science.gov (United States)

    1988-11-15

    for existence of a stabilizing control . The special case of an infinite dimensional dynamical system which has the characteristics of a contraction...provided sufficient conditions leading to the existence of a stabilizing control . It can be shown that under the condition of contraction, the

  17. Standardization of positive controls in diagnostic immunohistochemistry

    DEFF Research Database (Denmark)

    Torlakovic, Emina E; Nielsen, Søren; Francis, Glenn

    2015-01-01

    controls that are intended to facilitate methodology transfer and harmonization in dIHC. Furthermore, the committee has clarified definitions of IHC assay sensitivity and specificity, with special emphasis on how these definitions apply to positive controls. Recommendations for "best laboratory practice...

  18. Combustion diagnostic for active engine feedback control

    Science.gov (United States)

    Green, Jr., Johney Boyd; Daw, Charles Stuart; Wagner, Robert Milton

    2007-10-02

    This invention detects the crank angle location where combustion switches from premixed to diffusion, referred to as the transition index, and uses that location to define integration limits that measure the portions of heat released during the combustion process that occur during the premixed and diffusion phases. Those integrated premixed and diffusion values are used to develop a metric referred to as the combustion index. The combustion index is defined as the integrated diffusion contribution divided by the integrated premixed contribution. As the EGR rate is increased enough to enter the low temperature combustion regime, PM emissions decrease because more of the combustion process is occurring over the premixed portion of the heat release rate profile and the diffusion portion has been significantly reduced. This information is used to detect when the engine is or is not operating in a low temperature combustion mode and provides that feedback to an engine control algorithm.

  19. Remote network control plasma diagnostic system for Tokamak T-10

    Science.gov (United States)

    Troynov, V. I.; Zimin, A. M.; Krupin, V. A.; Notkin, G. E.; Nurgaliev, M. R.

    2016-09-01

    The parameters of molecular plasma in closed magnetic trap is studied in this paper. Using the system of molecular diagnostics, which was designed by the authors on the «Tokamak T-10» facility, the radiation of hydrogen isotopes at the plasma edge is investigated. The scheme of optical radiation registration within visible spectrum is described. For visualization, identification and processing of registered molecular spectra a new software is developed using MatLab environment. The software also includes electronic atlas of electronic-vibrational-rotational transitions for molecules of protium and deuterium. To register radiation from limiter cross-section a network control system is designed using the means of the Internet/Intranet. Remote control system diagram and methods are given. The examples of web-interfaces for working out equipment control scenarios and viewing of results are provided. After test run in Intranet, the remote diagnostic system will be accessible through Internet.

  20. Control and diagnostic data structures for the MFTF

    Energy Technology Data Exchange (ETDEWEB)

    Wade, J.A.; Choy, J.H.

    1979-11-12

    A Data Base Management System (DBMS) is being written as an integral part of the Supervisory Control and Diagnostics System (SCDS) of programs for control of the Mirror Fusion Test Facility (MFTF). The data upon which the DBMS operates consist of control values and evaluative information required for facilities control, along with control values and disgnostic data acquired as a result of each MFTF shot. The user interface to the DBMS essentially consists of two views: a computer program interface called the Program Level Interface (PLI) and a stand-alone interactive program called the Query Level Interface to support terminal-based queries. This paper deals specifically with the data structure capabilities from the viewpoint of the PLI user.

  1. [Process management and controlling in diagnostic radiology in the hospital].

    Science.gov (United States)

    Gocke, P; Debatin, J F; Dürselen, L F J

    2002-05-01

    Systematic process management and efficient quality control is rapidly gaining importance in our healthcare system. What does this mean for diagnostic radiology departments? To improve efficiency, quality and productivity the workflow within the department of diagnostic and interventional radiology at the University Hospital of Essen were restructured over the last two years. Furthermore, a controlling system was established. One of the pursued aims was to create a quality management system as a basis for the subsequent certification according to the ISO EN 9001:2000 norm. Central to the success of the workflow reorganisation was the training of selected members of the department's staff in process and quality management theory. Thereafter, a dedicated working group was created to prepare the reorganisation and the subsequent ISO certification with the support of a consulting partner. To assure a smooth implementation of the restructured workflow and create acceptance for the required ISO-9001 documentation, the entire staff was familiarized with the basic ideas of process- and quality-management in several training sessions. This manuscript summarizes the basic concepts of process and quality management as they were taught to our staff. A direct relationship towards diagnostic radiology is maintained throughout the text.

  2. DEVELOPMENT OF HYDROLOGICAL CABLEWAY SAND CONTROL MEASUREMENT INSTRUMENT BASED ON THE DOUBLE AUDIO FREQUENCY SIGNAL CONTROL%基于双音频信号控制的水文缆道测沙自控仪的研制

    Institute of Scientific and Technical Information of China (English)

    康修洪; 李先哲; 肖英; 朱兵

    2015-01-01

    According to the automatic cable measurement instruments widely used in hydrologic station, which has some problems such as cannot measurement and sampling sediment normally, we carried out the development of hydrological cableway sand control measurement instrument. The automatic control instrument will organically combine double tube double steady water sample collected valves and lead fish, reasonable decorate into the drainage pipeline and communication lines, the horizontal and vertical of hydrological cableway operate accurate positions, with double audio signal to transmit reliable control subsea sampler valve switch, acquisition section of each location, different depth of water samples, and send back the valve switch status signal in time. Practice has proved that the adoption of double tube double steady water samples collected valves can solve the problem of inlet pipe alluvial sediment under closed pressure, at the same time valve no need to seal. It also implements the hydrological monitoring data two-way transmission control of the bank to the water and the water to the shore.%针对水文站中普遍使用的自动缆道测流仪器,均存在进水阀密封、信号控制、与缆道测流系统整合等诸多问题,研制了一种基于嵌入式的水文缆道测沙自控仪。该自控仪将双管双稳态水样采集阀门与铅鱼有机结合,合理布置进排水管线和通讯线路,水文缆道的水平和垂直运行准确定位,采用双音频信号传输可靠的控制水下采样器阀门的开关,测取断面各位置,不同水深的水样,并及时发回阀门开关状况信号。实践证明,由于采用了双管双稳态水样采集阀门解决了关闭状态下进水管淤积泥沙问题,同时阀门不必进行全密封,还实现了水文监测数据岸上至水中和水中至岸上的双向控制传输,研制的仪器获得成功应用。

  3. Condition monitoring, diagnostic and controlling tool for boiler feed pump

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Sohail [Siemens AG, Muelheim (Germany). Energy Sector; Leithner, Reinhard; Kosyna, Guenter [TU Braunschweig (Germany)

    2010-07-01

    The boiler feed pump is an important component of a thermal power generation cycle and demands high safety and unquestionable availability for flexible power plant operation. In this research paper, the methodology of a general purpose condition monitoring, diagnostic and controlling tool is presented, which can address the challenges of operational safety and availability as well as optimal operation of a boiler feed pump. This tool not only effectively records the life time consumption of both casings and rotors and monitors the small gaps between casings and rotors but also suggests appropriate actions in order to ensure that the pump operates within the allowable design limits. (orig.)

  4. TPX diagnostics for tokamak operation, plasma control and machine protection

    Energy Technology Data Exchange (ETDEWEB)

    Edmonds, P.H. [Texas Univ., Austin, TX (United States). Fusion Research Center; Medley, S.S.; Young, K.M. [Princeton Univ., NJ (United States). Plasma Physics Lab.] [and others

    1995-08-01

    The diagnostics for TPX are at an early design phase, with emphasis on the diagnostic access interface with the major tokamak components. Account has to be taken of the very severe environment for diagnostic components located inside the vacuum vessel. The placement of subcontracts for the design and fabrication of the diagnostic systems is in process.

  5. Bacterial biofilm formation, pathogenicity, diagnostics and control: An overview

    Directory of Open Access Journals (Sweden)

    Sawhney Rajesh

    2009-07-01

    Full Text Available Bacterial biofilms are complex, mono- or poly-microbialn communities adhering to biotic or abiotic surfaces. This adaptation has been implicated as a survival strategy. The formation of biofilms is mediated by mechanical, biochemical and genetical factors. The biofilms enhance the virulence of the pathogen and have their potential role in various infections, such as dental caries, cystic fibrosis, osteonecrosis, urinary tract infection and eye infections. A number of diagnostic techniques, viz., bright-field microscopy, epifluorescence microscopy, scanning electron microscopy, confocal laser scanning microscopy and amplicon length heterogeneity polymerase chain reaction, have been employed for detection of these communities. Researchers have worked on applications of catheter lock solutions, a fish protein coating, acid shock treatment, susceptibility to bacteriophages, etc., for biofilm control. However, we need to rearrange our strategies to have thorough insight and concentrate on priority basis to develop new accurate, precise and rapid diagnostic protocols for detection and evaluation of biofilm. Above all, the strict compliance to these techniques is required for accurate diagnosis and control.

  6. Controls and Beam Diagnostics for Therapy-Accelerators

    CERN Document Server

    Eickhoff, H

    2000-01-01

    During the last four years GSI has developed a new procedure for cancer treatment by means of the intensity controlled rasterscan-method. This method includes active variations of beam parameters during the treatment session and the integration of 'on-line' PET monitoring. Starting in 1997 several patients have been successfully treated within this GSI experimental cancer treatment program; within this program about 350 patients shall be treated in the next 5 years. The developments and experiences of this program accompanied by intensive discussions with the medical community led to a proposal for a hospital based light ion accelerator facility for the clinic in Heidelberg. An essential part for patients treatments is the measurement of the beam properties within acceptance and constancy tests and especially for the rasterscan method during the treatment sessions. The presented description of the accelerator controls and beam diagnostic devices mainly covers the requests for the active scanning method, which...

  7. Quality control for diagnostic oral microbiology laboratories in European countries

    Directory of Open Access Journals (Sweden)

    Andrew J. Smith

    2011-11-01

    Full Text Available Participation in diagnostic microbiology internal and external quality control (QC processes is good laboratory practice and an essential component of a quality management system. However, no QC scheme for diagnostic oral microbiology existed until 2009 when the Clinical Oral Microbiology (COMB Network was created. At the European Oral Microbiology Workshop in 2008, 12 laboratories processing clinical oral microbiological samples were identified. All these were recruited to participate into the study and six laboratories from six European countries completed both the online survey and the first QC round. Three additional laboratories participated in the second round. Based on the survey, European oral microbiology laboratories process a significant (mean per laboratory 4,135 number of diagnostic samples from the oral cavity annually. A majority of the laboratories did not participate in any internal or external QC programme and nearly half of the laboratories did not have standard operating procedures for the tests they performed. In both QC rounds, there was a large variation in the results, interpretation and reporting of antibiotic susceptibility testing among the laboratories. In conclusion, the results of this study demonstrate the need for harmonisation of laboratory processing methods and interpretation of results for oral microbiology specimens. The QC rounds highlighted the value of external QC in evaluating the efficacy and safety of processes, materials and methods used in the laboratory. The use of standardised methods is also a prerequisite for multi-centre epidemiological studies that can provide important information on emerging microbes and trends in anti-microbial susceptibility for empirical prescribing in oro-facial infections.

  8. Overview of Propulsion Controls and Diagnostics Research at NASA Glenn

    Science.gov (United States)

    Garg, Sanjay

    2012-01-01

    With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. The Controls and Dynamics Branch (CDB) at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet these challenges through the concept of an Intelligent Engine. CDB conducts propulsion control and diagnostics research in support of various programs and projects under the NASA Aeronautics Research Mission Directorate and the Human Exploration and Operations Mission Directorate. The paper first provides an overview of the various research tasks in CDB relative to the NASA programs and projects, and briefly describes the progress being made on each of these tasks. The discussion here is at a high level providing the objectives of the tasks, the technical challenges in meeting the objectives and most recent accomplishments. References are provided for each of the technical tasks for the reader to familiarize themselves with the details.

  9. Advantages of the nested case-control design in diagnostic research

    NARCIS (Netherlands)

    Biesheuvel, Cornelis J.; Vergouwe, Yvonne; Oudega, Ruud; Hoes, Arno W.; Grobbee, Diederick E.; Moons, Karel Gm

    2008-01-01

    Background: Despite its benefits, it is uncommon to apply the nested case-control design in diagnostic research. We aim to show advantages of this design for diagnostic accuracy studies. Methods: We used data from a full cross-sectional diagnostic study comprising a cohort of 1295 consecutive patien

  10. Quality control in diagnostic immunohistochemistry: integrated on-slide positive controls.

    Science.gov (United States)

    Bragoni, A; Gambella, A; Pigozzi, S; Grigolini, M; Fiocca, R; Mastracci, L; Grillo, F

    2017-07-17

    Standardization in immunohistochemistry is a priority in modern pathology and requires strict quality control. Cost containment has also become fundamental and auditing of all procedures must take into account both these principles. Positive controls must be routinely performed so that their positivity guarantees the appropriateness of the immunohistochemical procedure. The aim of this study is to develop a low cost (utilizing a punch biopsy-PB-tool) procedure to construct positive controls which can be integrated in the patient's tissue slide. Sixteen frequently used control blocks were selected and multiple cylindrical samples were obtained using a 5-mm diameter punch biopsy tool, separately re-embedding them in single blocks. For each diagnostic immunoreaction requiring a positive control, an integrated PB-control section (cut from the appropriate PB-control block) was added to the top right corner of the diagnostic slide before immunostaining. This integrated control technique permitted a saving of 4.75% in total direct lab costs and proved to be technically feasible and reliable. Our proposal is easy to perform and within the reach of all pathology labs, requires easily available tools, its application costs is less than using external paired controls and ensures that a specific control for each slide is always available.

  11. Remote Control of TJ-II Diagnostics; Control Remoto de Diagnosticos del Dispositivo TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Sanchez, A.; Vega, J.; Montoro, A.; Encabo, J.

    2001-07-01

    The present paper is about the design and development of ten remote control diagnostic systems used in the study of plasma fusion in the TJ-II device installed at CIEMAT. This development goes from the definition of sensors and devices necessary in carrying out these remote controls, to its assembly, wiring, development of electronic circuits inserted between sensors and PLC, development of programs for these PLC, connections and administration of the real time automation network, and later development of the necessary programs via the appropriate software tools for web access through a navigator to a specific web page, allowing visual and real time access over the auxiliary systems that make up all the diagnostics. (Author)

  12. Diagnostics for plasma control on DEMO: challenges of implementation

    NARCIS (Netherlands)

    Donne, A. J. H.; Costley, A. E.; Morris, A. W.

    2012-01-01

    As a test fusion power plant, DEMO will have to demonstrate reliability and very long pulse/steady-state operation, which calls for unprecedented robustness and reliability of all diagnostic systems (also requiring adequate redundancy). But DEMO will have higher levels of neutron and gamma fluxes, a

  13. Diagnostics for plasma control on DEMO: challenges of implementation

    NARCIS (Netherlands)

    Donne, A. J. H.; Costley, A. E.; Morris, A. W.

    2012-01-01

    As a test fusion power plant, DEMO will have to demonstrate reliability and very long pulse/steady-state operation, which calls for unprecedented robustness and reliability of all diagnostic systems (also requiring adequate redundancy). But DEMO will have higher levels of neutron and gamma fluxes,

  14. First Steps Toward Incorporating Image Based Diagnostics Into Particle Accelerator Control Systems Using Convolutional Neural Networks

    OpenAIRE

    Edelen, A. L.; Biedron, S. G.; Milton, S. V.; Edelen, J. P.

    2016-01-01

    At present, a variety of image-based diagnostics are used in particle accelerator systems. Often times, these are viewed by a human operator who then makes appropriate adjustments to the machine. Given recent advances in using convolutional neural networks (CNNs) for image processing, it should be possible to use image diagnostics directly in control routines (NN-based or otherwise). This is especially appealing for non-intercepting diagnostics that could run continuously during beam operatio...

  15. Optical spectroscopy for tissue diagnostics and treatment control

    OpenAIRE

    Yavari, Nazila

    2006-01-01

    Biomedical Optics as an interdisciplinary field of science has been developed during many years and is experiencing tremendous growth, to cover a wide range of optical techniques and methods, utilized for medical therapeutic and diagnostic purposes. Biomedical optics contributes by introducing methods and creation of devices used in healthcare of various specialties, such as ophthalmology, cardiology, surgery, dermatology, oncology, radiology, etc. Each of these specialities mi...

  16. Use of the target diagnostic control system in the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Shelton, R; Lagin, L; Nelson, J

    2011-07-25

    The extreme physics of targets shocked by NIF's 192-beam laser are observed by a diverse suite of diagnostics including optical backscatter, time-integrated, time resolved and gated X-ray sensors, laser velocity interferometry, and neutron time of flight. Diagnostics to diagnose fusion ignition implosion and neutron emissions have been developed. A Diagnostic Control System (DCS) for both hardware and software facilitates development and eases integration. Each complex diagnostic typically uses an ensemble of electronic instruments attached to sensors, digitizers, cameras, and other devices. In the DCS architecture each instrument is interfaced to a low-cost Window XP processor and Java application. Instruments are aggregated as needed in the supervisory system to form an integrated diagnostic. The Java framework provides data management, control services and operator GUI generation. During the past several years, over thirty-six diagnostics have been deployed using this architecture in support of the National Ignition Campaign (NIC). The DCS architecture facilitates the expected additions and upgrades to diagnostics as more experiments are performed. This paper presents the DCS architecture, framework and our experiences in using it during the NIC to operate, upgrade and maintain a large set of diagnostic instruments.

  17. Process management and controlling in diagnostic radiology; Prozessmanagement und Controlling in der Diagnostischen Radiologie im Krankenhaus

    Energy Technology Data Exchange (ETDEWEB)

    Gocke, P.; Debatin, J.F. [Institut fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Essen (Germany); Duerselen, L.F.J. [DxD Consulting, Dogern (Germany)

    2002-05-01

    Systematic process management and efficient quality control is rapidly gaining importance in our healthcare system. What does this mean for diagnostic radiology departments?To improve efficiency, quality and productivity the workflow within the department of diagnostic and interventional radiology at the University Hospital of Essen were restructured over the last two years. Furthermore, a controlling system was established. One of the pursued aims was to create a quality management system as a basis for the subsequent certification according to the ISO EN 9001:2000 norm.Central to the success of the workflow reorganisation was the training of selected members of the department's staff in process and quality management theory. Thereafter, a dedicated working group was created to prepare the reorganisation and the subsequent ISO certification with the support of a consulting partner. To assure a smooth implementation of the restructured workflow and create acceptance for the required ISO-9001 documentation, the entire staff was familiarized with the basic ideas of process- and quality-management in several training sessions.This manuscript summarizes the basic concepts of process and quality management as they were taught to our staff. A direct relationship towards diagnostic radiology is maintained throughout the text. (orig.) [German] Systematisches Prozessmanagement und effizientes Qualitaetsmanagement erlangen im Gesundheitswesen zunehmend an Bedeutung. Was bedeutet dies fuer die diagnostische Radiologie im Krankenhaus?Zur Steigerung von Effizienz, Qualitaet und Produktivitaet wurden im Institut fuer Diagnostische und Interventionelle Radiologie des Universitaetsklinikums Essen in den vergangenen beiden Jahren nahezu saemtliche Arbeitsablaeufe reorganisiert. Darueber hinaus wurde ein Controllingsystem etabliert. Eines der damit verbundenen Ziele war es, ein Qualitaetsmanagementsystem zu erstellen, welches Grundlage fuer die angestrebte ISO-EN-9001

  18. A double faced ionization chamber for quality control in diagnostic radiology beams.

    Science.gov (United States)

    Silva, Jonas O; Caldas, Linda V E

    2012-07-01

    The development of new radiation detectors of low cost but with adequate materials is a very important task for countries that have to import ionization chambers such as Brazil. A special double faced ionization chamber was developed for use in conventional diagnostic radiology beams and computed tomography energy ranges. The results show that this new chamber present applicability in conventional diagnostic radiology and computed tomography quality control programs.

  19. [The diagnostic value of tests for mental control].

    Science.gov (United States)

    Lindeboom, J; Koene, T; Matto, D

    1993-06-01

    Designated as Mental Control, the recitation of word lists and arithmetic progressions is often used for a cursory examination of attention and concentration in elderly patients. We studied the psychometric properties of the EMCT (Expanded Mental Control Test), which consists of 12 mental control tasks. The test was given to 174 residents of rest homes and semi-independent housing projects (aged 68 to 94) and 74 neurologic patients (aged 65 to 87) who had been referred for neuropsychological assessment. The reliability of the EMCT was satisfactory. Performance was related to education level but not to sex or age. In healthy subjects the EMCT score was associated with the backward digit span score. The correlations between the EMCT and subtests of the Amsterdam Dementia Screening (Ads6) in patients appeared to depend on the complexity of the target behavior. Performance on the EMCT may reflect the functioning of the Supervisory Attentional System postulated by Shallice.

  20. Magnetic Diagnostics For Equilibrium Reconstruction And Realtime Plasma Control In NSTX-Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Gerhardt, Stefan P. [PPPL; Erickson, Keith [PPPL; Kaita, Robert [PPPL; Lawson, John [PPPL; Mozulay, Robert [PPPL; Mueller, Dennis [PPPL; Que, Weiguo [PPPL; Rahman, Nabidur [PPPL; Schneider, Hans [PPPL; Smalley, Gustav [PPPL; Tresemer, Kelsey [PPPL

    2014-06-01

    This paper describes aspects of magnetic diagnostics for realtime control in NSTX-U. The sensor arrangement on the upgraded center column is described. New analog and digital circuitry for processing the plasma current rogowski data are presented. An improved algorithm for estimating the plasma vertical velocity for feedback control is presented.

  1. Application of statistical process control to qualitative molecular diagnostic assays.

    Directory of Open Access Journals (Sweden)

    Cathal P O'brien

    2014-11-01

    Full Text Available Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control. Such a system is absent from the majority of molecular laboratories and where present is confined to quantitative assays. As the inability to apply statistical process control to assay is an obvious disadvantage this study aimed to solve this problem by using a frequency estimate coupled with a confidence interval calculation to detect deviations from an expected mutation frequency. The results of this study demonstrate the strengths and weaknesses of this approach and highlight minimum sample number requirements. Notably, assays with low mutation frequencies and detection of small deviations from an expected value require greater samples with a resultant protracted time to detection. Modelled laboratory data was also used to highlight how this approach might be applied in a routine molecular laboratory. This article is the first to describe the application of statistical process control to qualitative laboratory data.

  2. Conceptual architecture of the plant system controller for the magnetics diagnostic of the ITER tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A.C., E-mail: Andre.Neto@f4e.europa.eu [Fusion for Energy, 08019 Barcelona (Spain); Arshad, S.; Sartori, F. [Fusion for Energy, 08019 Barcelona (Spain); Vayakis, G. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); Ambrosino, G. [Consorzio CREATE/Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione, Università degli Studi di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Batista, A. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal); Bas, I. [GTD Sistemas de Información, 08005 Barcelona (Spain); Campagnolo, R. [Fusion for Energy, 08019 Barcelona (Spain); Carvalho, B.B. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal); De Magneval, G. [GTD Sistemas de Información, 08005 Barcelona (Spain); De Tommasi, G. [Consorzio CREATE/Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione, Università degli Studi di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Dominguez, O. [GTD Sistemas de Información, 08005 Barcelona (Spain); Fernandez-Hernando, J.L. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); Pironti, A. [Consorzio CREATE/Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’Informazione, Università degli Studi di Napoli Federico II, Via Claudio 21, 80125 Napoli (Italy); Simrock, S. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); and others

    2015-10-15

    In a tokamak the magnetic diagnostics are key to the exploitation of the machine. They play a central role in the real-time control of fundamental plasma properties, such as the plasma shape and position, while also contributing with important data to a better understanding of the plasma physics. One of the particular challenges of the ITER magnetics diagnostic is the need to balance high system reliability with sufficient freedom to tune and improve the quality of the diagnostic physics output. This requirement calls for a design pattern where the functions related to plasma control and protection are loosely coupled with the functions related to the plasma science. This work reports on the current status of the magnetics plant system controller design and discusses some possible design solutions that address the aforementioned issue.

  3. High Temperature PEM Fuel Cell Systems, Control and Diagnostics

    DEFF Research Database (Denmark)

    Andreasen, Søren Juhl; Kær, Søren Knudsen; Justesen, Kristian Kjær

    2015-01-01

    Various system topologies are available when it comes to designing high temperature PEM fuel cell systems. Very simple system designs are possible using pure hydrogen, and more complex system designs present themselves when alternative fuels are desired, using reformer systems. The use of reformed...... fuels utilizes one of the main advantages of the high temperature PEM fuel cell: robustness to fuel quality and impurities. In order for such systems to provide efficient, robust, and reliable energy, proper control strategies are needed. The complexity and nonlinearity of many of the components...

  4. Application of statistical process control to qualitative molecular diagnostic assays

    LENUS (Irish Health Repository)

    O'Brien, Cathal P.

    2014-11-01

    Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control (SPC). Such a system is absent from the majority of molecular laboratories and where present is confined to quantitative assays. As the inability to apply SPC to an assay is an obvious disadvantage this study aimed to solve this problem by using a frequency estimate coupled with a confidence interval calculation to detect deviations from an expected mutation frequency. The results of this study demonstrate the strengths and weaknesses of this approach and highlight minimum sample number requirements. Notably, assays with low mutation frequencies and detection of small deviations from an expected value require greater sample numbers to mitigate a protracted time to detection. Modeled laboratory data was also used to highlight how this approach might be applied in a routine molecular laboratory. This article is the first to describe the application of SPC to qualitative laboratory data.

  5. Design of Onboard Instrument Based on Virtual Instrument Technology

    Institute of Scientific and Technical Information of China (English)

    TANG Baoping; ZHONG Yuanchang; QIU Jianwei

    2006-01-01

    After analyzing and comparing the traditional automobile instrument, the onboard instrument based on virtual instrument technology is designed in this paper. The PC/104 computer was employed as the core processing unit of the onboard instrument, and the several intelligent data acquisition nodes are set and connected by the CAN bus, through which the nodes can communicate with the core processing unit. The information of the vehicle's working condition can be displayed synthetically by adopting virtual instrument technology. When the working condition goes beyond its limit, the system can emit an alarm, record and storage the abnormal condition automatically, and suggest how to deal with the abnormity urgently. The development background and design idea of onboard information system were elaborated in the paper. The software, the hardware architecture and the principle of onboard information system were introduced in detail.

  6. [Systematic teaching of differential diagnostics and information retrieval in medical education--a controlled study].

    Science.gov (United States)

    Renko, Marjo; Soini, Hannu; Rantala, Heikki; Tapiainen, Terhi; Pokka, Tytti; Uhari, Matti

    2010-01-01

    Teaching of differential diagnostic skills in medical education is often nonsystematic and touched only in a disease-based manner in the context of patient cases. We conducted a controlled study, in which a portion of fifth year students received systematic teaching of differential diagnostics and information retrieval for a period of ten weeks, whereas another portion continued in conventional basic training. We tested the students' problem-solving skills in both groups with a computer-assisted test. Students in the intervention group were more successful in the test and settled on the correct diagnosis more often than students in the control group.

  7. National Ignition Facility, subsystem design requirements beam control {ampersand} laser diagnostics SSDR 1.7

    Energy Technology Data Exchange (ETDEWEB)

    Bliss, E.

    1996-11-01

    This Subsystem Design Requirement document is a development specification that establishes the performance, design, development, and test requirements for the Alignment subsystem (WBS 1.7.1), Beam Diagnostics (WBS 1.7.2), and the Wavefront Control subsystem (WBS 1.7. 3) of the NIF Laser System (WBS 1.3). These three subsystems are collectively referred to as the Beam Control & Laser Diagnostics Subsystem. The NIF is a multi-pass, 192-beam, high-power, neodymium-glass laser that meets requirements set forth in the NIF SDR 002 (Laser System). 3 figs., 3 tabs.

  8. Global Accelerator Network, Control Systems And Beam Diagnostics

    CERN Document Server

    Raich, U

    2003-01-01

    Falling funds force all accelerator centers to look for new sources of financing and for the most efficient way of implementing new projects. This very often leads to collaborations between institutes scattered around the globe, a problem well known to big high energy physics experiments. The collaborations working on big detectors e.g. for LHC started thinking about detector acquisition and control systems which can be remotely used from their respective home institutes with minimal support on the spot. This idea was taken up by A. Wagner from DESY for the TESLA machine, who proposed the “Global Accelerator Network” (GAN) enabling users from around the world to run an accelerator remotely. Questions around this subject that immediately come to mind Is the GAN only relevant to big labs ? Or is it reasonable e.g. for operators or engineers in charge to do certain manipulations from home? Are our instruments ready for the GAN? Does the fact of being “GAN ready” increa...

  9. Filaria control and elimination: diagnostic, monitoring and surveillance needs.

    Science.gov (United States)

    Molyneux, David H

    2009-04-01

    Gold standard diagnosis using blood films or skin snips has dimished relevance as mass drug distribution programmes for control of filaria infections expand. The view of 'diagnosis' and its relevance at the individual level has changed, as it has been recognised that the spectrum of programmatic processes (mapping, mass drug interventions, monitoring and evaluation, and surveillance) require different approaches as different questions are asked at each stage. The feasibility and relevance of skin biopsy or blood film examination is challenged when mass drug distribution seeks to treat all eligibles in communities. The need to expand programmes rapidly by identifying the highest risk communities has seen the development of rapid assessment methods, such as rapid epidemiological mapping of onchocerciasis (REMO) and rapid epidemiological assessment (REA) for onchocerciasis, immunochromatographic test (ICT)-based mapping for lymphatic filariasis (LF), and Rapid Assessment Procedure for Loiasis (RAPLOA) for Loa, to reduce the risk of serious adverse events and to guide projects in high-risk communities. As programmes reduce the prevalence through mass drug distribution, more sensitive techniques are required to define endpoints, for LF in particular where the programmatic goal is elimination; for onchocerciasis, sensitive surveillance tools are required particularly in those areas where such risks of recrudescence are high. Whilst much progress has been made in the development and deployment of rapid methods, there are still specific needs for antigen detection in onchocerciasis, whilst standardisation of a panel of tools for LF will allow the definition of endpoint parameters so that countries can decide when mass drug administration (MDA) can be stopped and have a sensitive post-MDA surveillance system.

  10. First Steps Toward Incorporating Image Based Diagnostics Into Particle Accelerator Control Systems Using Convolutional Neural Networks

    Energy Technology Data Exchange (ETDEWEB)

    Edelen, A. L.; Biedron, S. G.; Milton, S. V.; Edelen, J. P.

    2016-12-16

    At present, a variety of image-based diagnostics are used in particle accelerator systems. Often times, these are viewed by a human operator who then makes appropriate adjustments to the machine. Given recent advances in using convolutional neural networks (CNNs) for image processing, it should be possible to use image diagnostics directly in control routines (NN-based or otherwise). This is especially appealing for non-intercepting diagnostics that could run continuously during beam operation. Here, we show results of a first step toward implementing such a controller: our trained CNN can predict multiple simulated downstream beam parameters at the Fermilab Accelerator Science and Technology (FAST) facility's low energy beamline using simulated virtual cathode laser images, gun phases, and solenoid strengths.

  11. A double faced ionization chamber for quality control in diagnostic radiology beams

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jonas O., E-mail: josofisico@yahoo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Av. Prof. Lineu Prestes, 2242, 05508-000, Sao Paulo (Brazil); Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Av. Prof. Lineu Prestes, 2242, 05508-000, Sao Paulo (Brazil)

    2012-07-15

    The development of new radiation detectors of low cost but with adequate materials is a very important task for countries that have to import ionization chambers such as Brazil. A special double faced ionization chamber was developed for use in conventional diagnostic radiology beams and computed tomography energy ranges. The results show that this new chamber present applicability in conventional diagnostic radiology and computed tomography quality control programs. - Highlights: Black-Right-Pointing-Pointer We constructed a double faced ionization chamber. Black-Right-Pointing-Pointer It was submitted to conventional diagnostic and computed tomography X-rays beams. Black-Right-Pointing-Pointer The results obtained showed good agreement with international standards. Black-Right-Pointing-Pointer This ionization chamber can be used in clinic quality control program.

  12. The control structure of team-based organizations : A diagnostic model for empowerment

    NARCIS (Netherlands)

    Kuipers, Benjamin; de Witte, M.C.

    2005-01-01

    This article describes a diagnostic model for empowerment in team-based organizations that portrays four dimensions of the organization's control structure: the level of routine, the nature of expertise, the level of dependence and the line of command. The combined positions of the set of job

  13. Generalizability of Diagnostic-Prescriptive Teaching Strategies across Student Locus of Control and Multiple Instructional Units.

    Science.gov (United States)

    Benson, Jean S.; Yeany, Russell H.

    Reported is a study that explores the effect on student achievement of diagnostic-prescriptive instructional strategies on preservice elementary education majors (N=43) enrolled in an introductory biology course. Factors of pre-treatment achievement and locus of control were analyzed as well. Units on Mendelian genetics, modern genetics, and…

  14. The control structure of team-based organizations : A diagnostic model for empowerment

    NARCIS (Netherlands)

    Kuipers, Benjamin; de Witte, M.C.

    2005-01-01

    This article describes a diagnostic model for empowerment in team-based organizations that portrays four dimensions of the organization's control structure: the level of routine, the nature of expertise, the level of dependence and the line of command. The combined positions of the set of job regula

  15. On line diagnostics and self-tuning method for the fluidized bed temperature controller

    Directory of Open Access Journals (Sweden)

    Porzuczek Jan

    2016-03-01

    Full Text Available The paper presents the method of on-line diagnostics of the bed temperature controller for the fluidized bed boiler. Proposed solution is based on the methods of statistical process control. Detected decrease of the bed temperature control quality is used to activate the controller self-tuning procedure. The algorithm that provides optimal tuning of the bed temperature controller is also proposed. The results of experimental verification of the presented method is attached. Experimental studies were carried out using the 2 MW bubbling fluidized bed boiler.

  16. Diagnostic assessment of search controls and failure modes in many-objective evolutionary optimization.

    Science.gov (United States)

    Hadka, David; Reed, Patrick

    2012-01-01

    The growing popularity of multiobjective evolutionary algorithms (MOEAs) for solving many-objective problems warrants the careful investigation of their search controls and failure modes. This study contributes a new diagnostic assessment framework for rigorously evaluating the effectiveness, reliability, efficiency, and controllability of MOEAs as well as identifying their search controls and failure modes. The framework is demonstrated using the recently introduced Borg MOEA, [Formula: see text]-NSGA-II, [Formula: see text]-MOEA, IBEA, OMOPSO, GDE3, MOEA/D, SPEA2, and NSGA-II on 33 instances of 18 test problems from the DTLZ, WFG, and CEC 2009 test suites. The diagnostic framework exploits Sobol's variance decomposition to provide guidance on the algorithms' non-separable, multi-parameter controls when performing a many-objective search. This study represents one of the most comprehensive empirical assessments of MOEAs ever completed.

  17. Logical and Timing Control for Diagnostic Neutral Beam Injection on HT-7

    Institute of Scientific and Technical Information of China (English)

    Du Shaowu; Ge Suoliang; Zhang Jian; Su Yu; Liu Baohua; Huang He

    2005-01-01

    The timing and master control logic (MCL) units are the most important function units of the diagnostic neutral beam (DNB) power supply control system. The units control the operation of nine power supply subsystems of the DNB system, and provide protection for the DNB system from faults such as beam source arc down. Based on the characteristics of the DNB power supply system, the timing and MCL units have been designed, fabricated and tested. Experiments prove that the timing unit is convenient, flexible and reliable, and the MCL is functional.

  18. Trichinella diagnostics and control: Mandatory and best practices for ensuring food safety

    DEFF Research Database (Denmark)

    Gajadhar, A. A.; Pozio, E.; Gamble, H. R.

    2009-01-01

    in all aspects of a Trichinella diagnostic system is emphasized. It includes the use of international quality standards, test validation and standardization, critical control points, laboratory accreditation, certification of analysts and proficiency testing. Also described, are the roles and locations......Because of its role in human disease, there are increasing global requirements for reliable diagnostic and control methods for Trichinella in food animals to ensure meat safety and to facilitate trade. Consequently, there is a need for standardization of methods, programs, and best practices used...... in various porcine and equine pre- and post-slaughter programs, including farm or herd certification programs is also discussed. A brief review of the effectiveness of meat processing methods, such as freezing, cooking and preserving is provided. The importance of proper quality assurance and its application...

  19. Commitments of Psychological Contracts and Diagnostic Use of Management Control Systems

    Directory of Open Access Journals (Sweden)

    Ivan Canan

    2016-06-01

    Full Text Available Investigating the commitments the Surveillance Agents from the National Telecommunications Agency (Anatel made in their psychological contracts and the diagnostic use of the management control system of the entity, this study tested the hypothesis that individuals tend to be more committed to aspects they are charged for within organizations. This is a theoretical and empirical study that assumed that the commitments comprise the part of the belief that individuals develop on reciprocal relations of exchange between themselves and their contractors, in line with the model by Rousseau (1989; 1995. It was also assumed that the extent to which aspects are charged from the members of an organization matches their perception of the diagnostic use of formal and informal control systems. Methodologically, the research was developed in two phases, the first qualitative, involving documentary analysis and content analysis of organizational documents; and the second quantitative, with the application of questionnaires answered by individuals who occupy the individual position referred to in the organization, who evaluated behavioral parameters that act on them and that were identified in the first phase. The data showed that 42 respondents tend to maintain high levels of commitment to the rules and standards proposed for their function. Statistical results also suggest that there is a significant positive correlation between the commitments assumed and the perceived diagnostic use of control systems for the surveillance agents who answered the questionnaire.

  20. The shape of the polarization curve and diagnostic criteria for control of the metal electrodeposition process

    Directory of Open Access Journals (Sweden)

    Popov Konstantin I.

    2016-01-01

    Full Text Available The simulated shapes of the polarization curves were correlated with the type of metal electrodeposition process control in a function of the exchange current density to the limiting diffusion current density (j0/jL ratios. Diagnostic criteria based on the j0/jL ratios were established. For j0/jL> 100, the system is under the ohmic control. In the range 1 < j0/jL ≤ 100 there is the mixed ohmic-diffusion control. The pure diffusion control appears in the range 0.1 < j0/jL £ 1. For j0/jL £ 0.1, the system is activation controlled at the low overpotentials. The proposed diagnostic criteria were verified by comparison of the simulated curves with experimentally recorded ones and by morphological analysis of deposits obtained in the different types of metal electrodeposition process control. [Projekat Ministarstva nauke Republike Srbije, br. 172046: Electrochemical synthesis and characterization of nanostructured functional materials for application in new technologies

  1. Architectures and Algorithms for Control and Diagnostics of Coupled-Bunch Instabilities in Circular Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2003-07-08

    Modern light sources and circular colliders employ large numbers of high-intensity particle bunches in order to achieve high luminosity. The electromagnetic coupling of bunches via resonant structures causes coherent instabilities at high beam currents. Achieving high luminosity requires the control of such unstable motion. Feedback control is challenging due to wideband nature of the problem with up to 250 MHz bandwidths required. This thesis presents digital signal processing architectures and diagnostic techniques for control of longitudinal and transverse coupled-bunch instabilities. Diagnostic capabilities integrated into the feedback system allow one to perform fast transient measurements of unstable dynamics by perturbing the beam from the controlled state via feedback and recording the time-domain response. Such measurements enable one to thoroughly characterize plant (beam) dynamics as well as performance of the feedback system. Beam dynamics can change significantly over the operating range of accelerator currents and energies . Here we present several methods for design of robust stabilizing feedback controllers. Experimental results from several accelerators are presented. A new baseband architecture for transverse feedback is described that compactly implements the digital processing functions using field-programmable gate array devices. The architecture is designed to be software configurable so that the same hardware can be used for instability control in different accelerators.

  2. Moving beyond quality control in diagnostic radiology and the role of the clinically qualified medical physicist.

    Science.gov (United States)

    Delis, H; Christaki, K; Healy, B; Loreti, G; Poli, G L; Toroi, P; Meghzifene, A

    2017-09-01

    Quality control (QC), according to ISO definitions, represents the most basic level of quality. It is considered to be the snapshot of the performance or the characteristics of a product or service, in order to verify that it complies with the requirements. Although it is usually believed that "the role of medical physicists in Diagnostic Radiology is QC", this, not only limits the contribution of medical physicists, but is also no longer adequate to meet the needs of Diagnostic Radiology in terms of Quality. In order to assure quality practices more organized activities and efforts are required in the modern era of diagnostic radiology. The complete system of QC is just one element of a comprehensive quality assurance (QA) program that aims at ensuring that the requirements of quality of a product or service will consistently be fulfilled. A comprehensive Quality system, starts even before the procurement of any equipment, as the need analysis and the development of specifications are important components under the QA framework. Further expanding this framework of QA, a comprehensive Quality Management System can provide additional benefits to a Diagnostic Radiology service. Harmonized policies and procedures and elements such as mission statement or job descriptions can provide clarity and consistency in the services provided, enhancing the outcome and representing a solid platform for quality improvement. The International Atomic Energy Agency (IAEA) promotes this comprehensive quality approach in diagnostic imaging and especially supports the field of comprehensive clinical audits as a tool for quality improvement. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  3. [ACTUAL PROBLEMS OF EPIDEMIOLOGIC CONTROL, LABORATORY DIAGNOSTICS AND PROPHYLAXIS OF CHOLERA IN RUSSIAN FEDERATION].

    Science.gov (United States)

    Onischenko, G G; Popova, A Yu; Kutyrev, V V; Smirnova, N I; Scherbakova, S A; Moskvitina, E A; Titova, S V

    2016-01-01

    Main problems of system of epidemiologic control for cholera active in Russian Federation, as well as laboratory diagnostics and vaccine prophylaxis of this especially dangerous infection, that had emerged in the contemporary period of the ongoing 7th pandemic of cholera, are discussed. Features of the genome of natural strains of Vibrio cholerae of El Tor biovar, that possess a poten- tial epidemic threat, as well as problems, that have emerged during isolation of these strains from samples of water of surface water bodies during their monitoring, are also examined. The main direction of enhancement of the system of epidemiologic control for cholera consist in develop- ment of a new algorithm of differentiation of administrative territories of Russian Federation by types of epidemic manifestations, as well as optimization of monitoring of environment objects. Integration of modern highly informative technologies into practice, as well as development of new generation diagnostic preparations based on DNA-chips and immunechips is necessary to increase effectiveness of the conducted operative and retrospective diagnostics in the contemporary period. Creation of national cholera vaccine, ensuring simultaneous protection from cholera causative agents of both O1 and O139 serogroups, is also required.

  4. Effects of a Web-Based Decision Aid Regarding Diagnostic Self-Testing. A Single-Blind Randomized Controlled Trial

    Science.gov (United States)

    Ickenroth, Martine H. P.; Grispen, J. E. J.; de Vries, N. K.; Dinant, G. J.; Ronda, G.; van der Weijden, T.

    2016-01-01

    Currently, there are many diagnostic self-tests on body materials available to consumers. The aim of this study was to assess the effect of an online decision aid on diagnostic self-testing for cholesterol and diabetes on knowledge among consumers with an intention to take these tests. A randomized controlled trial was designed. A total of 1259…

  5. Bioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays

    Science.gov (United States)

    Lam, Patricia; Gulati, Neetu M.; Stewart, Phoebe L.; Keri, Ruth A.; Steinmetz, Nicole F.

    2016-03-01

    The 2014 Ebola epidemic is the largest to date. There is no cure or treatment for this deadly disease; therefore there is an urgent need to develop new diagnostics to accurately detect Ebola. Current RT-PCR assays lack sensitive and reliable positive controls. To address this critical need, we devised a bio-inspired positive control for use in RT-PCR diagnostics: we encapsulated scrambled Ebola RNA sequences inside of tobacco mosaic virus to create a biomimicry that is non-infectious, but stable, and could therefore serve as a positive control in Ebola diagnostic assays. Here, we report the bioengineering and validation of this probe.

  6. About the Big Graphs Arising when Forming the Diagnostic Models in a Reconfigurable Computing Field of Functional Monitoring and Diagnostics System of the Spacecraft Onboard Control Complex

    Directory of Open Access Journals (Sweden)

    L. V. Savkin

    2015-01-01

    Full Text Available One of the problems in implementation of the multipurpose complete systems based on the reconfigurable computing fields (RCF is the problem of optimum redistribution of logicalarithmetic resources in growing scope of functional tasks. Irrespective of complexity, all of them are transformed into an orgraph, which functional and topological structure is appropriately imposed on the RCF based, as a rule, on the field programmable gate array (FPGA.Due to limitation of the hardware configurations and functions realized by means of the switched logical blocks (SLB, the abovementioned problem becomes even more critical when there is a need, within the strictly allocated RCF fragment, to realize even more complex challenge in comparison with the problem which was solved during the previous computing step. In such cases it is possible to speak about graphs of big dimensions with respect to allocated RCF fragment.The article considers this problem through development of diagnostic algorithms to implement diagnostics and control of an onboard control complex of the spacecraft using RCF. It gives examples of big graphs arising with respect to allocated RCF fragment when forming the hardware levels of a diagnostic model, which, in this case, is any hardware-based algorithm of diagnostics in RCF.The article reviews examples of arising big graphs when forming the complicated diagnostic models due to drastic difference in formation of hardware levels on closely located RCF fragments. It also pays attention to big graphs emerging when the multichannel diagnostic models are formed.Three main ways to solve the problem of big graphs with respect to allocated RCF fragment are given. These are: splitting the graph into fragments, use of pop-up windows with relocating and memorizing intermediate values of functions of high hardware levels of diagnostic models, and deep adaptive update of diagnostic model.It is shown that the last of three ways is the most efficient

  7. Diagnostic options for radiative divertor feedback control on NSTX-U.

    Science.gov (United States)

    Soukhanovskii, V A; Gerhardt, S P; Kaita, R; McLean, A G; Raman, R

    2012-10-01

    A radiative divertor technique is used in present tokamak experiments and planned for ITER to mitigate high heat loads on divertor plasma-facing components (PFCs) to prevent excessive material erosion and thermal damage. In NSTX, a large spherical tokamak with lithium-coated graphite PFCs and high divertor heat flux (q(peak) ≤ 15 MW/m(2)), radiative divertor experiments have demonstrated a significant reduction of divertor peak heat flux simultaneously with good core H-mode confinement using pre-programmed D(2) or CD(4) gas injections. In this work diagnostic options for a new real-time feedback control system for active radiative divertor detachment control in NSTX-U, where steady-state peak divertor heat fluxes are projected to reach 20-30 MW/m(2), are discussed. Based on the NSTX divertor detachment measurements and analysis, the control diagnostic signals available for NSTX-U include divertor radiated power, neutral pressure, spectroscopic deuterium recombination signatures, infrared thermography of PFC surfaces, and thermoelectric scrape-off layer current. In addition, spectroscopic "security" monitoring of possible confinement or pedestal degradation is recommended. These signals would be implemented in a digital plasma control system to manage the divertor detachment process via an actuator (impurity gas seeding rate).

  8. Fast elaboration of diagnostic data for real time control in FTU tokamak

    Directory of Open Access Journals (Sweden)

    Nowak S.

    2012-09-01

    Full Text Available The automatic controller developed for MHD instability control on FTU via the real time (RT EC launcher [1, 2] is based on the a-priori estimate of the instabilities location and on the fast elaboration of the stream of diagnostic data. A fast data acquisition system, based on existing standard FTU diagnostics, collects thermal and magnetic signals by a 12-channels ECE polychromator [3] and by a set of 22 Mirnov coils respectively. Moreover, the EC time waveform from directional couplers along the transmission line is acquired as well. This set of signals is processed in a timescale significantly shorter than the typical time step of the controller (1ms. RT elaboration algorithms aim at supplying the controller [4] with reliable information about the existence and the spatial location of the instability and about the actual ECRH deposition layer in plasma. The main algorithms blocks are ECE-ECE, ECE-Mirnov and ECE-ECRH cross-correlation, and SVD (Singular Value Decomposition of Mirnov signals. The capabilities of effective detection, false positive resilience, and mode discrimination will be discussed through the application to actual plasma data.

  9. Diagnostic options for radiative divertor feedback control on NSTX-U

    Energy Technology Data Exchange (ETDEWEB)

    Soukhanovskii, V. A.; Gerhardt, S. P.; Kaita, R.; McLean, A. G.; Raman, R.

    2012-10-01

    A radiative divertor technique is used in present tokamak experiments and planned for ITER to mitigate high heat loads on divertor plasma-facing components (PFCs) to prevent excessive material erosion and thermal damage. In NSTX, a large spherical tokamak with lithium-coated graphite PFCs and high divertor heat flux (qpeak ≤ 15 MW/m2), radiative divertor experiments have demonstrated a significant reduction of divertor peak heat flux simultaneously with good core H-mode confinement using pre-programmed D2 or CD4 gas injections. In this work diagnostic options for a new real-time feedback control system for active radiative divertor detachment control in NSTX-U, where steady-state peak divertor heat fluxes are projected to reach 20–30 MW/m2, are discussed. Based on the NSTX divertor detachment measurements and analysis, the control diagnostic signals available for NSTX-U include divertor radiated power, neutral pressure, spectroscopic deuterium recombination signatures, infrared thermography of PFC surfaces, and thermoelectric scrape-off layer current. In addition, spectroscopic “security” monitoring of possible confinement or pedestal degradation is recommended. These signals would be implemented in a digital plasma control system to manage the divertor detachment process via an actuator (impurity gas seeding rate).

  10. Combining principles of Cognitive Load Theory and diagnostic error analysis for designing job aids: Effects on motivation and diagnostic performance in a process control task.

    Science.gov (United States)

    Kluge, Annette; Grauel, Britta; Burkolter, Dina

    2013-03-01

    Two studies are presented in which the design of a procedural aid and the impact of an additional decision aid for process control were assessed. In Study 1, a procedural aid was developed that avoids imposing unnecessary extraneous cognitive load on novices when controlling a complex technical system. This newly designed procedural aid positively affected germane load, attention, satisfaction, motivation, knowledge acquisition and diagnostic speed for novel faults. In Study 2, the effect of a decision aid for use before the procedural aid was investigated, which was developed based on an analysis of diagnostic errors committed in Study 1. Results showed that novices were able to diagnose both novel faults and practised faults, and were even faster at diagnosing novel faults. This research contributes to the question of how to optimally support novices in dealing with technical faults in process control.

  11. Bioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays

    National Research Council Canada - National Science Library

    Lam, Patricia; Gulati, Neetu M; Stewart, Phoebe L; Keri, Ruth A; Steinmetz, Nicole F

    2016-01-01

    ...: we encapsulated scrambled Ebola RNA sequences inside of tobacco mosaic virus to create a biomimicry that is non-infectious, but stable, and could therefore serve as a positive control in Ebola diagnostic assays...

  12. Virtual Instrument Based on GPIB Interface Bus1

    Institute of Scientific and Technical Information of China (English)

    Xiao,Ying; Qi,Hanhong

    2004-01-01

    In this paper, we introduced the technique of GPIB businterface. Through the controlling of the GPIB interface board,the computer controlled the current source and the voltmeter, both of which have GPIB bus interface, and a virtual instrument testing system for I~V curve was composed. The virtual instrument front panel and the background graphical control program in Labview environment accomplish virtual instrument testing task along with the hardware system.

  13. Comparative Autonomic Responses to Diagnostic Interviewing between Individuals with GAD, MDD, SAD and Healthy Controls

    Science.gov (United States)

    Diamond, Allison E.; Fisher, Aaron J.

    2017-01-01

    Dysregulation of the autonomic nervous system (ANS) has been well documented in individuals diagnosed with a range of psychological disorders, including generalized anxiety disorder (GAD) and major depressive disorder (MDD). Moreover, these disorders both confer an increased risk of cardiovascular disease—which may relate to increased sympathetic and decreased parasympathetic tone. Extant research has indicated a reduction in autonomic flexibility in GAD, and while reduced flexibility has also been seen in MDD, the specific physiological alterations have been more difficult to categorize due to methodological limitations, including high co-morbidity rates with anxiety disorders. Prior studies have largely assessed autonomic functioning in stress paradigms or at the trait level, yet to date, no research has investigated the ANS during a diagnostic interview, a ubiquitous task employed in both research and clinical settings. In this study we sought to identify physiological differences in both branches of the ANS across diagnostic categories in the context of a diagnostic interview. Participants (n = 82) were administered a structured clinical interview, during which heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) were recorded in participants carrying a diagnosis of GAD (n = 34), MDD (n = 22), Social Anxiety Disorder (SAD; n = 15) and healthy controls (n = 27). Person-specific linear regression models were employed to assess the level and slope for HR, RSA and PEP throughout the course of the interview. A multivariate analysis of variance (MANOVA) model was conducted to baseline differences in HR, RSA and PEP between diagnostic groups. Multiple regression models were then conducted to differences in slope of HR, RSA and PEP throughout the course of the interview amongst diagnostic groups, including both suppression and worry as moderators. Results indicated significant increases in RSA throughout the interview in MDD (p = 0

  14. Unravelling abiotic and biotic controls on the seasonal water balance using data-driven dimensionless diagnostics

    Science.gov (United States)

    Seibert, Simon Paul; Jackisch, Conrad; Ehret, Uwe; Pfister, Laurent; Zehe, Erwin

    2017-06-01

    The baffling diversity of runoff generation processes, alongside our sketchy understanding of how physiographic characteristics control fundamental hydrological functions of water collection, storage, and release, continue to pose major research challenges in catchment hydrology. Here, we propose innovative data-driven diagnostic signatures for overcoming the prevailing status quo in catchment inter-comparison. More specifically, we present dimensionless double mass curves (dDMC) which allow inference of information on runoff generation and the water balance at the seasonal and annual timescales. By separating the vegetation and winter periods, dDMC furthermore provide information on the role of biotic and abiotic controls in seasonal runoff formation. A key aspect we address in this paper is the derivation of dimensionless expressions of fluxes which ensure the comparability of the signatures in space and time. We achieve this by using the limiting factors of a hydrological process as a scaling reference. We show that different references result in different diagnostics. As such we define two kinds of dDMC which allow us to derive seasonal runoff coefficients and to characterize dimensionless streamflow release as a function of the potential renewal rate of the soil storage. We expect these signatures for storage controlled seasonal runoff formation to remain invariant, as long as the ratios of release over supply and supply over storage capacity develop similarly in different catchments. We test the proposed methods by applying them to an operational data set comprising 22 catchments (12-166 km2) from different environments in southern Germany and hydrometeorological data from 4 hydrological years. The diagnostics are used to compare the sites and to reveal the dominant controls on runoff formation. The key findings are that dDMC are meaningful signatures for catchment runoff formation at the seasonal to annual scale and that the type of scaling strongly

  15. The Development of a Framework for Target Diagnostic Centralized Control System (TDCCS) in ICF Experiments

    Science.gov (United States)

    Zhang, Chi; Wang, Jian; Yu, Xiaoqi; Yang, Dong

    2008-02-01

    A framework for target diagnostic centralized control system (TDCCS) in inertial confinement fusion (ICF) experiment has been developed. The developed framework is based on the common object request broker architecture (CORBA) standard and part of the concept from the ICFRoot (a framework based on ROOT for ICF experiments) framework design. This framework is of a component architecture, including a message bus, command executer, status processor, parser and proxy. To test the function of the framework, a simplified prototype of the TDCCS has been developed as well.

  16. Control of Multibunch Longitudinal Instabilities and Beam Diagnostics Using a DSP-based Feedback System

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2000-03-30

    A bunch-by-bunch longitudinal feedback system has been designed and built to control coupled-bunch instabilities in the PEP-II machine. A prototype system has been installed at the Advanced Light Source at LBNL. Programmable DSPs allow longitudinal feedback processing in conjunction with data acquisition or instrumentation algorithms. Here the authors describe techniques developed for different beam and system diagnostics, such as measurements of the modal growth and damping rates and measurements of the bunch-by-bunch currents. Results from the Advanced Light Source are presented to illustrate these techniques.

  17. Introducing new diagnostics into STI control programmes: the importance of programme science.

    Science.gov (United States)

    Peeling, Rosanna W; Mabey, David; Ballard, Ronald C

    2013-03-01

    Many innovative diagnostic technologies will become commercially available over the next 5-10 years. These tests can potentially transform the diagnosis of sexually transmitted infections but their introduction into control programmes can be hampered by health system constraints, and political, cultural, socioeconomic and behavioural factors. We used the introduction of syphilis rapid tests to illustrate the importance of programme science to address the gap between accruing evidence of acceptable test performance and the complexity of programme design, implementation and evaluation of test deployment to address public health needs and improve patient-important outcomes.

  18. Development of instrumentation and control systems for the ITER diagnostic systems in JADA

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Tsuyoshi, E-mail: yamamoto.tsuyoshi@jaea.go.jp [Japan Atomic Energy Agency, Naka-shi, Ibaraki (Japan); Hashimoto, Yasunori [Japan Expert Clone Corporation, Shinjuku-ku, Tokyo (Japan); Kitazawa, Sin-iti; Yatsuka, Eiichi; Hatae, Takaki; Sugie, Tatsuo; Ogawa, Hiroaki; Takeuchi, Masaki; Kawano, Yasunori; Itami, Kiyoshi [Japan Atomic Energy Agency, Naka-shi, Ibaraki (Japan)

    2015-10-15

    Highlights: • JADA developed a prototype I&C system for ITER divertor thermocouples. • Conversion tool from SFC flowchart to EPICS record source codes was developed. • Python-base sequence control management function was developed. - Abstract: Japan Domestic Agency (JADA) is responsible for six diagnostic systems in the ITER project. We have successfully developed a prototype instrumentation and control (I&C) system for the ITER divertor thermocouples system. The prototype I&C system includes a supervisory function, a sequencing management function, and a data acquisition function. The supervisory function, which was implemented using EPICS (Experimental Physics and Industrial Control System), manages internal operations for measurement such as health check of sensors. We developed a conversion tool from flowcharts to EPICS record source codes. The EPICS records generated by the conversion tool are used to trigger each operation step and to indicate the progress of the sequence. We also developed the sequencing management function that coordinates the execution of operation steps. Both the flowchart conversion tool and sequencing management function were developed to reduce designers’ mistakes and to ensure rapid development. The prototype I&C system for the DTC was tested. We confirmed that the I&C system performed satisfying the requirements. This validated design will be applied to other ITER diagnostic systems procured by JADA.

  19. Air Breathing Propulsion Controls and Diagnostics Research at NASA Glenn Under NASA Aeronautics Research Mission Programs

    Science.gov (United States)

    Garg, Sanjay

    2015-01-01

    The Intelligent Control and Autonomy Branch (ICA) at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet the goals of the NASA Aeronautics Research Mission Directorate (ARMD) Programs. These efforts are primarily under the various projects under the Advanced Air Vehicles Program (AAVP), Airspace Operations and Safety Program (AOSP) and Transformative Aeronautics Concepts Program (TAC). The ICA Branch is focused on advancing the state-of-the-art of aero-engine control and diagnostics technologies to help improve aviation safety, increase efficiency, and enable operation with reduced emissions. This paper describes the various ICA research efforts under the NASA Aeronautics Research Mission Programs with a summary of motivation, background, technical approach, and recent accomplishments for each of the research tasks.

  20. New Diagnostic, Launch and Model Control Techniques in the NASA Ames HFFAF Ballistic Range

    Science.gov (United States)

    Bogdanoff, David W.

    2012-01-01

    This report presents new diagnostic, launch and model control techniques used in the NASA Ames HFFAF ballistic range. High speed movies were used to view the sabot separation process and the passage of the model through the model splap paper. Cavities in the rear of the sabot, to catch the muzzle blast of the gun, were used to control sabot finger separation angles and distances. Inserts were installed in the powder chamber to greatly reduce the ullage volume (empty space) in the chamber. This resulted in much more complete and repeatable combustion of the powder and hence, in much more repeatable muzzle velocities. Sheets of paper or cardstock, impacting one half of the model, were used to control the amplitudes of the model pitch oscillations.

  1. An Electron Beam Profile Instrument Based on FBGs

    Directory of Open Access Journals (Sweden)

    Dan Sporea

    2014-08-01

    Full Text Available Along with the dose rate and the total irradiation dose measurements, the knowledge of the beam localization and the beam profile/energy distribution in the beam are parameters of interest for charged particle accelerator installations when they are used in scientific investigations, industrial applications or medical treatments. The transverse profile of the beam, its position, its centroid location, and its focus or flatness depend on the instrument operating conditions or on the beam exit setup. Proof-of-concept of a new type of charged particle beam diagnostics based on fiber Bragg gratings (FBGs was demonstrated. Its operating principle relies on the measurement of the peak wavelength changes for an array of FBG sensors as function of the temperature following the exposure to an electron beam. Periodically, the sensor irradiation is stopped and the FBG are force cooled to a reference temperature with which the temperature influencing each sensor during beam exposure is compared. Commercially available FBGs, and FBGs written in radiation resistant optical fibers, were tested under electron beam irradiation in order to study their possible use in this application.

  2. Automated System for Control of the Vacuum Diagnostic System for the TJ-II; Control Automatico de los Sistemas de Vacio de Diagnosticos del Dispositivos TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Sanchez, A.; Montoro Peinado, A.; Encabo Fernandez, J.; Gama de la Serrano, J.; Sanchez Sarabia, E. [Ciemat, Madrid (Spain)

    2000-07-01

    This report describes the monitorization and remote control systems belonging to the high vacuum systems of the TJ-II diagnostics. These systems are part of each diagnostic and their control has been integrated into the automata that carries out this task. All the controllers are connected through a Profibus network, so as to interchange data between themselves as well as between the general system of TJ-II. (Author)

  3. Development of a novel recombinant encapsidated RNA particle: evaluation as an internal control for diagnostic RT-PCR

    DEFF Research Database (Denmark)

    King, Donald P.; Montague, Nick; Ebert, Katja

    2007-01-01

    This report describes the generation of novel encapsidated RNA particles and their evaluation as in-tube internal controls in diagnostic real-time reverse-transcription PCR (rRT-PCR) assays for the detection of RNA viruses. A cassette containing sequences of 2 diagnostic primer sets for foot...... unguiculata). RNA contained in these particles was amplified in diagnostic rRT-PCR assays used for detection of FMDV and SVDV. Amplification of these internal controls was used to confirm that rRT-PCR inhibitors were absent from clinical samples, thereby verifying negative assay results. The recombinant CPMVs...... did not reduce the analytical sensitivity of the rRT-PCRs when amplification of the insert was performed in the same tube as the diagnostic target. This system provides an attractive solution to the production of internal controls for rRT-PCR assays since CPMV grows to high yields in plants...

  4. Development of a novel recombinant encapsidated RNA particle: evaluation as an internal control for diagnostic RT-PCR

    DEFF Research Database (Denmark)

    King, Donald P.; Montague, Nick; Ebert, Katja

    2007-01-01

    did not reduce the analytical sensitivity of the rRT-PCRs when amplification of the insert was performed in the same tube as the diagnostic target. This system provides an attractive solution to the production of internal controls for rRT-PCR assays since CPMV grows to high yields in plants......This report describes the generation of novel encapsidated RNA particles and their evaluation as in-tube internal controls in diagnostic real-time reverse-transcription PCR (rRT-PCR) assays for the detection of RNA viruses. A cassette containing sequences of 2 diagnostic primer sets for foot...... unguiculata). RNA contained in these particles was amplified in diagnostic rRT-PCR assays used for detection of FMDV and SVDV. Amplification of these internal controls was used to confirm that rRT-PCR inhibitors were absent from clinical samples, thereby verifying negative assay results. The recombinant CPMVs...

  5. Application of hybridization control probe to increase accuracy on ligation detection or minisequencing diagnostic microarrays

    Directory of Open Access Journals (Sweden)

    Hultman Jenni

    2009-12-01

    Full Text Available Abstract Background Nucleic acid detection based on ligation reaction or single nucleotide extension of ssDNA probes followed by tag microarray hybridization provides an accurate and sensitive detection tool for various diagnostic purposes. Since microarray quality is crucial for reliable detection, these methods can benefit from correcting for microarray artefacts using specifically adapted techniques. Findings Here we demonstrate the application of a per-spot hybridization control oligonucleotide probe and a novel way of computing normalization for tag array data. The method takes into account the absolute value of the detection probe signal and the variability in the control probe signal to significantly alleviate problems caused by artefacts and noise on low quality microarrays. Conclusions Diagnostic microarray platforms require experimental and computational tools to enable efficient correction of array artefacts. The techniques presented here improve the signal to noise ratio and help in determining true positives with better statistical significance and in allowing the use of arrays with poor quality that would otherwise be discarded.

  6. A Bayesian framework to assess the potential for controlling classical scrapie in sheep flocks using a live diagnostic test.

    Science.gov (United States)

    Gryspeirt, Aiko; Gubbins, Simon

    2013-09-01

    Current strategies to control classical scrapie remove animals at risk of scrapie rather than those known to be infected with the scrapie agent. Advances in diagnostic tests, however, suggest that a more targeted approach involving the application of a rapid live test may be feasible in future. Here we consider the use of two diagnostic tests: recto-anal mucosa-associated lymphatic tissue (RAMALT) biopsies; and a blood-based assay. To assess their impact we developed a stochastic age- and prion protein (PrP) genotype-structured model for the dynamics of scrapie within a sheep flock. Parameters were estimated in a Bayesian framework to facilitate integration of a number of disparate datasets and to allow parameter uncertainty to be incorporated in model predictions. In small flocks a control strategy based on removal of clinical cases was sufficient to control disease and more stringent measures (including the use of a live diagnostic test) did not significantly reduce outbreak size or duration. In medium or large flocks strategies in which a large proportion of animals are tested with either live diagnostic test significantly reduced outbreak size, but not always duration, compared with removal of clinical cases. However, the current Compulsory Scrapie Flocks Scheme (CSFS) significantly reduced outbreak size and duration compared with both removal of clinical cases and all strategies using a live diagnostic test. Accordingly, under the assumptions made in the present study there is little benefit from implementing a control strategy which makes use of a live diagnostic test.

  7. Pain in diagnostic hysteroscopy: a multivariate analysis after a randomized, controlled trial.

    Science.gov (United States)

    Mazzon, Ivan; Favilli, Alessandro; Grasso, Mario; Horvath, Stefano; Bini, Vittorio; Di Renzo, Gian Carlo; Gerli, Sandro

    2014-11-01

    To study which variables are able to influence women's experience of pain during diagnostic hysteroscopy. Multivariate analysis (phase II) after a randomized, controlled trial (phase I). Endoscopic gynecologic center. In phase I, 392 patients were analyzed. Group A: 197 women with carbon dioxide (CO2); group B: 195 women with normal saline. In phase II, 392 patients were assigned to two different groups according to their pain experience as measured by a visual analogue scale (VAS): group VAS>3 (170 patients); group VAS≤3 (222 patients). Free-anesthesia diagnostic hysteroscopy performed using CO2 or normal saline as distension media. Procedure time, VAS score, image quality, and side effects during and after diagnostic hysteroscopy. In phase I the median pain score in group A was 2, whereas in group B it was 3. In phase II the duration of the procedure, nulliparity, and the use of normal saline were significantly correlated with VAS>3. A higher presence of cervical synechiae was observed in the group VAS>3. The multivariate analysis revealed an inverse correlation between parity and a VAS>3, whereas the use of normal saline, the presence of synechiae in the cervical canal, and the duration of the hysteroscopy were all directly correlated to a VAS score>3. Pain in hysteroscopy is significantly related to the presence of cervical synechiae, to the duration of the procedure, and to the use of normal saline; conversely, parity seems to have a protective role. NCT01873391. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  8. 77 FR 72409 - Manufacturer of Controlled Substances; Notice of Application: Siemens Healthcare Diagnostics, Inc.

    Science.gov (United States)

    2012-12-05

    ... Diagnostics, Inc. Pursuant to Sec. 1301.33(a) Title 21 of the Code of Federal Regulations (CFR), this is notice that on November 7, 2012, Siemens Healthcare Diagnostics, Inc., Attn: RA, 100 GBC Drive, Mail...

  9. 77 FR 31390 - Manufacturer of Controlled Substances; Notice of Registration; Siemens Healthcare Diagnostics, Inc.

    Science.gov (United States)

    2012-05-25

    ... Diagnostics, Inc. By Notice dated January 26, 2012, and published in the Federal Register on February 6, 2012, 77 FR 5847, Siemens Healthcare Diagnostics Inc., 100 GBC Drive, Mail Stop 514, Newark, Delaware 19702.... 823(a) and determined that the registration of Siemens Healthcare Diagnostics Inc., to manufacture...

  10. 78 FR 19017 - Manufacturer of Controlled Substances; Notice of Registration; Siemens Healthcare Diagnostics, Inc.

    Science.gov (United States)

    2013-03-28

    ... Diagnostics, Inc. By Notice dated November 27, 2012, and published in the Federal Register on December 5, 2012, 77 FR 72409, Siemens Healthcare Diagnostics Inc., Attn: RA, 100 GBC Drive, Mail Stop 514, Newark.... 823(a) and determined that the registration of Siemens Healthcare Diagnostics Inc., to manufacture...

  11. Development of intelligent control system for X-ray streak camera in diagnostic instrument manipulator

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Chengquan [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China); Wu, Shengli, E-mail: slwu@mail.xjtu.edu.cn [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China); Tian, Jinshou [Xi' an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China); Liu, Zhen [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China); Fang, Yuman [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Gao, Guilong; Liang, Lingliang [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China); Xi' an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi' an 710119 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Wen, Wenlong [Key Laboratory for Physical Electronics and Devices of the Ministry of Education, Xi' an Jiaotong University, Xi' an 710049 (China)

    2015-11-01

    An intelligent control system for an X ray streak camera in a diagnostic instrument manipulator (DIM) is proposed and implemented, which can control time delay, electric focusing, image gain adjustment, switch of sweep voltage, acquiring environment parameters etc. The system consists of 16 A/D converters and 16 D/A converters, a 32-channel general purpose input/output (GPIO) and two sensors. An isolated DC/DC converter with multi-outputs and a single mode fiber were adopted to reduce the interference generated by the common ground among the A/D, D/A and I/O. The software was designed using graphical programming language and can remotely access the corresponding instrument from a website. The entire intelligent control system can acquire the desirable data at a speed of 30 Mb/s and store it for later analysis. The intelligent system was implemented on a streak camera in a DIM and it shows a temporal resolution of 11.25 ps, spatial distortion of less than 10% and dynamic range of 279:1. The intelligent control system has been successfully used in a streak camera to verify the synchronization of multi-channel laser on the Inertial Confinement Fusion Facility.

  12. Q fever outbreak in a goat herd--diagnostic investigations and measures for control.

    Science.gov (United States)

    Sting, Reinhard; Molz, Kerstin; Benesch, Christiane

    2013-01-01

    This is a case report about a Q fever infection of a goat herd with abortions and excretions of pathogens accompanied by human infection and disease. Following a diagnosis of Q fever in a goat herd, all animals were vaccinated with an inactivated phase 1 vaccine. The herd was kept isolated and animals were neither removed nor introduced so that monitoring of the course of the Q fever infection of the individual dam was possible. Over a period of two years following the diagnosis of a Q fever infection (abortion), diagnostic investigations on detection of Coxiella (C.) burnetii were performed using quantitative Real-Time PCR (qPCR) and for serological studies complement fixation test (CFT) and ELISA. Excretion of pathogens decreased from > 500 000 units per genital swab in the first year to control measures which were implemented after a round table meeting are illustrated and discussed.

  13. Method for Evaluating Information to Solve Problems of Control, Monitoring and Diagnostics

    Science.gov (United States)

    Vasil'ev, V. A.; Dobrynina, N. V.

    2017-06-01

    The article describes a method for evaluating information to solve problems of control, monitoring and diagnostics. It is necessary for reducing the dimensionality of informational indicators of situations, bringing them to relative units, for calculating generalized information indicators on their basis, ranking them by characteristic levels, for calculating the efficiency criterion of a system functioning in real time. The design of information evaluation system has been developed on its basis that allows analyzing, processing and assessing information about the object. Such object can be a complex technical, economic and social system. The method and the based system thereof can find a wide application in the field of analysis, processing and evaluation of information on the functioning of the systems, regardless of their purpose, goals, tasks and complexity. For example, they can be used to assess the innovation capacities of industrial enterprises and management decisions.

  14. A portable detection instrument based on DSP for beef marbling

    Science.gov (United States)

    Zhou, Tong; Peng, Yankun

    2014-05-01

    Beef marbling is one of the most important indices to assess beef quality. Beef marbling is graded by the measurement of the fat distribution density in the rib-eye region. However quality grades of beef in most of the beef slaughtering houses and businesses depend on trainees using their visual senses or comparing the beef slice to the Chinese standard sample cards. Manual grading demands not only great labor but it also lacks objectivity and accuracy. Aiming at the necessity of beef slaughtering houses and businesses, a beef marbling detection instrument was designed. The instrument employs Charge-coupled Device (CCD) imaging techniques, digital image processing, Digital Signal Processor (DSP) control and processing techniques and Liquid Crystal Display (LCD) screen display techniques. The TMS320DM642 digital signal processor of Texas Instruments (TI) is the core that combines high-speed data processing capabilities and real-time processing features. All processes such as image acquisition, data transmission, image processing algorithms and display were implemented on this instrument for a quick, efficient, and non-invasive detection of beef marbling. Structure of the system, working principle, hardware and software are introduced in detail. The device is compact and easy to transport. The instrument can determine the grade of beef marbling reliably and correctly.

  15. Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment

    Institute of Scientific and Technical Information of China (English)

    Andrii; Vislovukh; Thaiz; Rivera; Vargas; Anna; Polesskaya; Irina; Groisman

    2014-01-01

    The messenger RNA 3’-untranslated region(3’UTR)plays an important role in regulation of gene expres-sion on the posttranscriptional level. The 3’UTR con-trols gene expression via orchestrated interactionbetween the structural components of mRNAs(cis-ele-ment) and the specific trans-acting factors(RNA bind-ing proteins and non-coding RNAs). The crosstalk ofthese factors is based on the binding sequences and/or direct protein-protein interaction, or just functionalinteraction. Much new evidence that has accumulatedsupports the idea that several RNA binding factors canbind to common mRNA targets: to the non-overlappingbinding sites or to common sites in a competitive fash-ion. Various factors capable of binding to the sameRNA can cooperate or be antagonistic in their actions.The outcome of the collective function of all factorsbound to the same mRNA 3’UTR depends on manycircumstances, such as their expression levels, affinity to the binding sites, and localization in the cell, which can be controlled by various physiological conditions. Moreover, the functional and/or physical interactions of the factors binding to 3’UTR can change the character of their actions. These interactions vary during the cell cycle and in response to changing physiological condi-tions. Abnormal functioning of the factors can lead to disease. In this review we will discuss how alterations of these factors or their interaction can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these altera-tions and their impact on 3’UTR-directed posttran-scriptional gene regulation will uncover promising new targets for therapeutic intervention and diagnostics. We will also discuss emerging new tools in cancer di-agnostics and therapy based on 3’UTR binding factors and approaches to improve them.

  16. Quality control agent: Self-adaptive laser vibrometry for on-line diagnostics

    Science.gov (United States)

    Serafini, S.; Paone, N.; Castellini, P.

    2012-06-01

    It is presented the development of a self-adaptive diagnostic system based on laser vibrometry for production line quality control. The vibration measurement system consists of a laser Doppler vibrometer, equipped with scanning mirrors and a smart camera, which implements self-adaptivity for compensating target mis-positioning under guidance by a vision system and for the achievement of the best condition for measurement by optimizing the Doppler signal level. This system is designed as a Quality Control Agent (QCA) and it is part of a Multi Agent System (MAS) that supervises all the production line. The QCA behavior is defined so to perform a minimization of measurement uncertainty during the on line tests; for this purpose the QCA exhibits a self-adaptive behavior. Best measurement conditions are defined in terms of amplitude of the optical Doppler beat signal (signal quality - SQ). In this paper, the optimization strategy for measurement enhancement achieved by the down-hill algorithm (Nelder-Mead algorithm) and its effect on signal quality improvement is discussed. Tests on a washing machine in controlled operating conditions allow to evaluate the efficacy of the method; significant reduction of noise on vibration velocity spectra is observed.

  17. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis.

    Science.gov (United States)

    Utzinger, Jürg; N'goran, Eliézer K; Caffrey, Conor R; Keiser, Jennifer

    2011-09-01

    Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease. Schistosomiasis, perhaps more than any other disease, is entrenched in prevailing social-ecological systems, since transmission is governed by human behaviour (e.g. open defecation and patterns of unprotected surface water contacts) and ecological features (e.g. living in close proximity to suitable freshwater bodies in which intermediate host snails proliferate). Moreover, schistosomiasis is intimately linked with poverty and the disease has spread to previously non-endemic areas as a result of demographic, ecological and engineering transformations. Importantly though, thanks to increased advocacy there is growing awareness, financial and technical support to control and eventually eliminate schistosomiasis as a public health problem at local, regional and global scales. The purpose of this review is to highlight recent progress made in innovation, validation and application of new tools and strategies for research and integrated control of schistosomiasis. First, we explain that schistosomiasis is deeply embedded in social-ecological systems and explore linkages with poverty. We then summarize and challenge global statistics, risk maps and burden estimates of human schistosomiasis. Discovery and development research pertaining to novel diagnostics and drugs forms the centrepiece of our review. We discuss unresolved issues and emerging opportunities for integrated and sustainable control of schistosomiasis and conclude with a series of research needs. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Automated innovative diagnostic, data management and communication tool, for improving malaria vector control in endemic settings.

    Science.gov (United States)

    Vontas, John; Mitsakakis, Konstantinos; Zengerle, Roland; Yewhalaw, Delenasaw; Sikaala, Chadwick Haadezu; Etang, Josiane; Fallani, Matteo; Carman, Bill; Müller, Pie; Chouaïbou, Mouhamadou; Coleman, Marlize; Coleman, Michael

    2016-01-01

    Malaria is a life-threatening disease that caused more than 400,000 deaths in sub-Saharan Africa in 2015. Mass prevention of the disease is best achieved by vector control which heavily relies on the use of insecticides. Monitoring mosquito vector populations is an integral component of control programs and a prerequisite for effective interventions. Several individual methods are used for this task; however, there are obstacles to their uptake, as well as challenges in organizing, interpreting and communicating vector population data. The Horizon 2020 project "DMC-MALVEC" consortium will develop a fully integrated and automated multiplex vector-diagnostic platform (LabDisk) for characterizing mosquito populations in terms of species composition, Plasmodium infections and biochemical insecticide resistance markers. The LabDisk will be interfaced with a Disease Data Management System (DDMS), a custom made data management software which will collate and manage data from routine entomological monitoring activities providing information in a timely fashion based on user needs and in a standardized way. The ResistanceSim, a serious game, a modern ICT platform that uses interactive ways of communicating guidelines and exemplifying good practices of optimal use of interventions in the health sector will also be a key element. The use of the tool will teach operational end users the value of quality data (relevant, timely and accurate) to make informed decisions. The integrated system (LabDisk, DDMS & ResistanceSim) will be evaluated in four malaria endemic countries, representative of the vector control challenges in sub-Saharan Africa, (Cameroon, Ivory Coast, Ethiopia and Zambia), highly representative of malaria settings with different levels of endemicity and vector control challenges, to support informed decision-making in vector control and disease management.

  19. Bioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays

    OpenAIRE

    Patricia Lam; Gulati, Neetu M.; Stewart, Phoebe L.; Keri, Ruth A.; Steinmetz, Nicole F.

    2016-01-01

    The 2014 Ebola epidemic is the largest to date. There is no cure or treatment for this deadly disease; therefore there is an urgent need to develop new diagnostics to accurately detect Ebola. Current RT-PCR assays lack sensitive and reliable positive controls. To address this critical need, we devised a bio-inspired positive control for use in RT-PCR diagnostics: we encapsulated scrambled Ebola RNA sequences inside of tobacco mosaic virus to create a biomimicry that is non-infectious, but sta...

  20. Special diagnostic methods and beam loss control on high intensity proton synchrotrons and storage rings Circular proton accelerator

    CERN Document Server

    Warsop, C M

    2002-01-01

    Two topics concerning high intensity, medium energy, circular proton accelerators have been studied: specialist diagnostics and beam loss control. The use of specially configured, low intensity diagnostic beams to help measure, understand and control high intensity beams is described. The ideas are developed and demonstrated on the ISIS 800 MeV, high intensity proton synchrotron at the Rutherford Appleton Laboratory in the UK. It is shown that these techniques make much new and valuable information available, which is particularly useful in achieving the precise beam optimisation required for low and controlled losses. Beam loss control in the proposed European Spallation Source (ESS) accumulator rings is studied. The expected losses are summarised, and a design for the beam collimation system presented. A new code for the simulation of loss control is outlined, and then used to test the collimation system under most foreseeable conditions. It is expected that the required loss control levels will be achievab...

  1. Retooling national TB control programmes (NTPs with new diagnostics: the NTP perspective.

    Directory of Open Access Journals (Sweden)

    Sanne C van Kampen

    Full Text Available BACKGROUND: A delay is evident between the development of new policies on TB diagnostics and their implementation at country level. The Stop TB Partnership would benefit from information from national TB program (NTP managers on progress towards implementation of new recommendations as well as the opportunities and challenges encountered in the process. METHODS AND FINDINGS: To solicit information on the introduction of new TB diagnostics at country level, questionnaires were sent out to NTP managers of high-burden TB countries and a subset of managers was interviewed. The results indicate that about 50% of high-burden TB countries are using the TB diagnostic tools newly recommended by the World Health Organization (WHO. Most NTP managers reported that new diagnostics would only be implemented when officially endorsed by the WHO. All countries have plans to adopt newly endorsed diagnostics at reference laboratory level, while approaches to optimize smear microscopy at lower levels of the health service are given less attention. NTP managers reported diverse challenges to the implementation of new diagnostics. CONCLUSIONS: More information on the obstacles and advantages of introducing new diagnostic tools should be provided to NTP managers to ensure the rational adoption of new diagnostics. A single recommendation covering the introduction of a package of diagnostic tools might be preferable to NTP managers and facilitate implementation in high-burden TB countries.

  2. Diagnostics for schistosomiasis in Africa and Arabia: a review of present options in control and future needs for elimination.

    Science.gov (United States)

    Stothard, J Russell; Stanton, Michelle C; Bustinduy, Amaya L; Sousa-Figueiredo, José C; Van Dam, Govert J; Betson, Martha; Waterhouse, David; Ward, Steve; Allan, Fiona; Hassan, Amir A; Al-Helal, Mohammad A; Memish, Ziad A; Rollinson, David

    2014-12-01

    Within the World Health Organization 2012-2020 roadmap for control and elimination of schistosomiasis, the scale-up of mass drug administration with praziquantel is set to change the epidemiological landscape across Africa and Arabia. Central in measuring progress is renewed emphasis upon diagnostics which operate at individual, community and environmental levels by assessing reductions in disease, infections and parasite transmission. However, a fundamental tension is revealed between levels for present diagnostic tools, and methods applied in control settings are not necessarily adequate for application in elimination scenarios. Indeed navigating the transition from control to elimination needs careful consideration and planning. In the present context of control, we review current options for diagnosis of schistosomiasis at different levels, highlighting several strengths and weaknesses therein. Future challenges in elimination are raised and we propose that more cost-effective diagnostics and clinical staging algorithms are needed. Using the Kingdom of Saudi Arabia as a contemporary example, embedding new diagnostic methods within the primary care health system is discussed with reference to both urogenital and intestinal schistosomiasis.

  3. Tuberculosis diagnostic delay and its influencing factors in counties with or without TB control programme in Jiangsu Province

    Institute of Scientific and Technical Information of China (English)

    Xu Biao; Jiang Qingwu; Xiu Yan; Shi Suhong; Tang Jie

    2003-01-01

    @@ Rational: Early passive case finding based on good access to TB care is the cornerstones of effective TB control.The accessibility to TB care could be reflected by the diagnostic delay including the "Patient's delay" (from onset of symptoms to the first visit to a hospital), and the "Doctor's delay" (from the first hospital visit to obtaining TB diagnosis).

  4. Quality control for the in-clinic veterinary laboratory and pre-analytic considerations for specialized diagnostic testing.

    Science.gov (United States)

    Camus, Melinda S

    2016-09-01

    This review, aimed primarily at general practitioners, focuses on quality assurance/quality control principles for all three phases of clinical pathology testing: preanalytic, analytic, and postanalytic. Specific emphasis is placed on the preanalytic phase of diagnostic modalities for identifying neoplastic cells, specifically flow cytometry, PCR for antigen receptor rearrangement, and immunocytochemistry. Recommendations for establishing an in-clinic quality assurance system are provided.

  5. Quality control in diagnostic molecular pathology in the Netherlands; proficiency testing for patient identification in tissue samples.

    NARCIS (Netherlands)

    Thunnissen, F.B.J.M.; Tilanus, M.G.J.; Ligtenberg, M.J.L.; Nederlof, P.M.; Dinjens, W.N.; Meulemans, E.; Brule, A.J. van den; Noesel, C.J. van; Leeuw, W. de; Schuuring, E.

    2004-01-01

    AIMS: To describe the evolution of proficiency testing for molecular diagnostic pathology with respect to determining unambiguously the patient identity of tissue samples by microsatellite analysis. METHOD: Four rounds of quality control exchanges of samples from different patients were sent with th

  6. Intermediate frequency band digitized high dynamic range radiometer system for plasma diagnostics and real-time Tokamak control

    NARCIS (Netherlands)

    Bongers, WA.; Van Beveren, V.; Thoen, D.J.; Nuij, P.J.W.M.; De Baar, M.R.; Donné, A.J.H.; Westerhof, E.; Goede, A.P.H.; Krijger, B.; Van den Berg, M.A.; Kantor, M.; Graswinckel, M.F.; Hennen, B.A.; Schüller, F.C.

    2011-01-01

    An intermediate frequency (IF) band digitizing radiometer system in the 100–200 GHz frequency range has been developed for Tokamak diagnostics and control, and other fields of research which require a high flexibility in frequency resolution combined with a large bandwidth and the retrieval of the f

  7. Challenges to Providing a Successful Central Configuration Service to Support CERN’s New Controls Diagnostics and Monitoring System

    CERN Document Server

    Makonnen, Z; Zaharieva, Z

    2014-01-01

    The Controls Diagnostic and Monitoring service (DIAMON) provides monitoring and diagnostics tools to the operators in the CERN Control Centre. A recent reengineering presented the opportunity to restructure its data management and to integrate it with the central Controls Configuration Service (CCS). The CCS provides the Configuration Management for the Controls System for all accelerators at CERN. The new facility had to cater for the configuration management of all agents monitored by DIAMON, (>3000 computers of different types), provide deployment information, relations between metrics, and historical information. In addition, it had to be integrated into the operational CCS, while ensuring stability and data coherency. An important design decision was to largely reuse the existing infrastructure in the CCS and adapt the DIAMON data management to it e.g. by using the device/property model through a Virtual Devices framework to model the DIAMON agents. This article will show how these challenging requiremen...

  8. Peste des petits ruminants diagnosis and diagnostic tools at a glance: perspectives on global control and eradication.

    Science.gov (United States)

    Santhamani, Ramasamy; Singh, Rabindra Prasad; Njeumi, Felix

    2016-11-01

    Peste des petits ruminants (PPR) is a highly contagious, economically important viral disease of small ruminants, targeted for global eradication by the year 2030. The recent geographic surge in PPR virus distribution, economic implications, the success of the rinderpest eradication campaign, and ongoing national/regional efforts convinced the FAO and OIE to initiate a global PPR control and eradication strategy. Since its discovery, a series of diagnostic tools have been developed for detecting PPR virus and virus-specific antibodies. Furthermore, it is understood that diagnostic and vaccine-monitoring tools are inevitable components of the four-stage strategy of global PPR eradication from assessment to the post-eradication phase. However, these tools may not be suitable for all stages of PPR control and eradication. For instance, diagnostics such as ELISA could be used for mass screening of clinical and serum samples, whereas immunochromatographic tests can be used at the field level as a pen-side test. Yet, assays with higher sensitivity, such as RT-PCR, RT-PCR ELISA, real-time RT-PCR and LAMP are important for early diagnosis of PPR and also, theoretically, during the late stages of eradication or when sampling non-natural hosts. Moreover, during the later stages of any control program, suspected/doubtful outbreaks will have to be reconfirmed using multiple laboratory tests. Hence, diagnostics can and should be efficiently applied at different stages of the PPR control and eradication campaign based on available resources and the number of samples to be tested. This article provides an overview of the various PPR diagnostic tools and suggests where and how they should be logically applied during the different phases of global PPR control and eradication.

  9. Examination of the diagnostic validity of 'headache attributed to whiplash injury': a controlled, prospective study.

    Science.gov (United States)

    Schrader, H; Stovner, L J; Obelieniene, D; Surkiene, D; Mickeviciene, D; Bovim, G; Sand, T

    2006-11-01

    Acute and chronic headache attributed to whiplash injury are new diagnostic entities in the International Classification of Headache Disorders, second edition. A main objective of the present study was to assess the validity of these nosologic entities by studying the headache pattern in an inception cohort of 210 rear-end car collision victims and in 210 matched controls. Consecutive drivers involved in rear-end collisions were identified from the daily records of the Traffic Police Department of Kaunas, Lithuania. A standard self-report questionnaire was sent to the drivers between 2 and 7 days after the collision, and their passengers were recruited as well. Headache and neck pain were evaluated within 7 days of the collision, at 2 months and 1 year after the collision. A control group of non-traumatized subjects received questionnaires at the time of the selection and 1 year later. Of the 75 collision victims who developed headache within the first 7 days of the collision, 37 had a clinical picture in accordance with the criteria for acute whiplash headache (i.e., concomitant neck pain) and 38 did not. For acute headache after collision, concomitant neck pain was of no relevance to the headache type or its course. In both these subgroups, migraine and tension-type headache could be diagnosed in similar proportions and the prognosis after 2 months and 1 year was also similar. Preexisting headache was a strong prognostic factor in both groups for both acute and chronic pain. Compared with the non-traumatized control group, the 1-year incidence of new or worsened headache, or of headache improvement, was the same. A likely interpretation of the data is that acute headaches after rear-end car collisions mainly represent episodes of a primary headache precipitated by the stress of the situation. We conclude that the nosologic validity of both acute and chronic whiplash headache is poor as the headaches, in accordance with the criteria lack distinguishing clinical

  10. Merging Old and New: An Instrumentation-Based Introductory Analytical Laboratory

    Science.gov (United States)

    Jensen, Mark B.

    2015-01-01

    An instrumentation-based laboratory curriculum combining traditional unknown analyses with student-designed projects has been developed for an introductory analytical chemistry course. In the first half of the course, students develop laboratory skills and instrumental proficiency by rotating through six different instruments performing…

  11. The importance of quality assurance/quality control of diagnostics to increase the confidence in global foot-and-mouth disease control.

    Science.gov (United States)

    De Clercq, K; Goris, N; Barnett, P V; MacKay, D K

    2008-01-01

    The last decade international trade in animals and animal products was liberated and confidence in this global trade can increase only if appropriate control measures are applied. As foot-and-mouth disease (FMD) diagnostics will play an essential role in this respect, the Food and Agriculture Organization European Commission for the Control of Foot-and-Mouth Disease (EUFMD) co-ordinates, in collaboration with the European Commission, several programmes to increase the quality of FMD diagnostics. A quality assurance (QA) system is deemed essential for laboratories involved in certifying absence of FMDV or antibodies against the virus. Therefore, laboratories are encouraged to validate their diagnostic tests fully and to install a continuous quality control (QC) monitoring system. Knowledge of performance characteristics of diagnostics is essential to interpret results correctly and to calculate sample rates in regional surveillance campaigns. Different aspects of QA/QC of classical and new FMD virological and serological diagnostics are discussed in respect to the EU FMD directive (2003/85/EC). We recommended accepting trade certificates only from laboratories participating in international proficiency testing on a regular basis.

  12. Manual versus target-controlled infusion of balanced propofol during diagnostic colonoscopy: A prospective randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Vučićević Vera

    2016-01-01

    Full Text Available Introduction. There is an increasing interest in balanced propofol sedation (BPS for colonoscopy in outpatient settings. Propofol is a potent anesthetic agent for this purpose and has a narrow therapeutic range, which increases a risk of cardiovascular and respiratory complications in case of improper administration. Objective. The aim of this study was to compare patients’ safety and comfort of endoscopists in two methods of BPS targeting deep sedation - propofol target-controlled infusion (TCI and manual intravenous titration technique (MT - during colonoscopy. Methods. This prospective randomized controlled trial included 90 patients (class I or II of the American Society of Anesthesiologists deeply sedated with propofol, coadministered with small doses of midazolam and fentanyl. Propofol was given by MT technique (45 patients or by TCI (45 patients. The following adverse effects were recorded: hypotension, hypertension, bradycardia, tachycardia, hypoxemia, bradypnea, apnea, hiccupping, and coughing, as well as endoscopist’s comfort during colonoscopy by means of a questionnaire. Results. The MT group compared to the TCI group had a lower mean arterial pressure in the 10th minute after the beginning (p = 0.017, and at the end of colonoscopy (p = 0.006, higher oxygen saturation in the fifth minute (p = 0.033, and in the 15th minute (p = 0.008 after the beginning of colonoscopy, and lower heart rate at the beginning of the procedure (p = 0.001. There were no statistically significant differences in adverse events. Endoscopist’s comfort during colonoscopy was high 95.6% in the TCI group vs. 88.9% in the MT group (p = 0.069. Conclusion. MT is clinically as stable as TCI of propofol for deep sedation during colonoscopy, and endoscopists experienced the same comfort during colonoscopy in both groups. Thus, both combinations are suitable for deep sedation during diagnostic colonoscopy.

  13. A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape.

    Science.gov (United States)

    Castellanos, Elisabeth; Gel, Bernat; Rosas, Inma; Tornero, Eva; Santín, Sheila; Pluvinet, Raquel; Velasco, Juan; Sumoy, Lauro; Del Valle, Jesús; Perucho, Manuel; Blanco, Ignacio; Navarro, Matilde; Brunet, Joan; Pineda, Marta; Feliubadaló, Lidia; Capellá, Gabi; Lázaro, Conxi; Serra, Eduard

    2017-01-04

    We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. We improved bait design, tested different NGS platforms and created a clinically driven custom data analysis pipeline. The I2HCP panel was developed using a training set of hereditary colorectal cancer, hereditary breast and ovarian cancer and neurofibromatosis patients and reached an accuracy, analytical sensitivity and specificity greater than 99%, which was maintained in a validation set. I2HCP changed our diagnostic approach, involving clinicians and a genetic diagnostics team from panel design to reporting. The new strategy improved diagnostic sensitivity, solved uncertain clinical diagnoses and identified mutations in new genes. We assessed the genetic variation in the complete set of hereditary cancer genes, revealing a complex variation landscape that coexists with the disease-causing mutation. We developed, validated and implemented a custom NGS-based strategy for hereditary cancer diagnostics that improved our previous workflows. Additionally, the existence of a rich genetic variation in hereditary cancer genes favors the use of this panel to investigate their role in cancer risk.

  14. Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics

    Directory of Open Access Journals (Sweden)

    A. M. Popov

    2016-01-01

    Full Text Available Comparison of interpretation of acute lymphoblastic leukemia (ALL flow cytometric diagnostics data was the aim of the study. Immunophenotyping data obtained from 10 patients with ALL were analysed separately in 26 laboratories from Russian Federation and Kazahstan. Results comparison showed four main type of discordance: B-lineage ALL diagnostics during heavy bone marrow regeneration, great variability of T-ALL interpretation, complexity of ambiguous lineage acute leukemia and, finally, very different report types, unique for each laboratory. All these problems are the serious obstacles for standardization of flow cytometric ALL diagnostics in multicenter setting. Continuation of similar QC rounds following by consecutive discussions with further development of consensus diagnostic algorithm could be the first step for standardization of ALL immunophenotyping in Russian Federation and CIS countries.

  15. Real-Time Adaptive Algorithms for Flight Control Diagnostics and Prognostics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Model-based machinery diagnostic and prognostic techniques depend upon high-quality mathematical models of the plant. Modeling uncertainties and errors decrease...

  16. Quality control of direct molecular diagnostics for methicillin-resistant Staphylococcus aureus.

    NARCIS (Netherlands)

    A.F. van Belkum (Alex); H.G.M. Niesters (Bert); W.G. MacKay (William); W.B. van Leeuwen (Willem)

    2007-01-01

    textabstractTen samples containing various amounts of methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus, methicillin-resistant Staphylococcus epidermidis (MRSE), and combinations thereof were distributed to 51 laboratories for molecular diagnostics testing. Sample

  17. Quality control of direct molecular diagnostics for methicillin-resistant Staphylococcus aureus

    NARCIS (Netherlands)

    van Belkum, Alex; Niesters, Hubert G M; MacKay, William G; van Leeuwen, Willem B

    2007-01-01

    Ten samples containing various amounts of methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus, methicillin-resistant Staphylococcus epidermidis (MRSE), and combinations thereof were distributed to 51 laboratories for molecular diagnostics testing. Samples containing

  18. Combustion Control and Diagnostics Sensor Testing in a Thermal Barrier Coated Combustor

    Energy Technology Data Exchange (ETDEWEB)

    Chorpening, B.T.; Dukes, M.G.; Robey, E.H.; Thornton, J.D.

    2007-05-01

    The combustion control and diagnostics sensor (CCADS) continues to be developed as an in-situ combustion sensor, with immediate application to natural gas fired turbines. In-situ combustion monitoring is also expected to benefit advanced power plants of the future, fueled by coal-derived syngas, liquified natural gas (LNG), hydrogen, or hydrogen blend fuels. The in-situ monitoring that CCADS provides can enable the optimal operation of advanced, fuel-flexible turbines for minimal pollutant emissions and maximum efficiency over the full operating range of an advanced turbine. Previous work has demonstrated CCADS as a useful sensor for in-situ monitoring of natural gas combustion, including detection of important combustion events such as flashback and lean blowoff, in experimental combustors without thermal barrier coatings (TBC). Since typical TBC materials are electrical insulators at room temperature, and CCADS operation requires conduction of electrical current to the walls of the combustor, a TBC on the combustion liner was identified as a potential barrier to CCADS operation in commercial application. This paper reports on CCADS experiments in a turbulent lean premixed combustor with a yttria-stabilized zirconia (YSZ) thermal barrier coating on the combustor wall. The tests were conducted at 0.1 MPa (1 atm), with a 15V excitation voltage on the CCADS electrodes. The results confirm that for a typical thermal barrier coating, CCADS operates properly, and the total measured average resistance is close to that of an uncoated combustor. This result is consistent with previous materials studies that found the electrical resistance of typical TBC materials considerably decreases at combustor operating temperatures.

  19. Active control over carbon deposition on diagnostic components and in remote areas of ITER

    NARCIS (Netherlands)

    Litnovsky, A.; Philipps, V.; Wienhold, P.; Matveeva, M.; Pospieszczyk, A.; Sergienko, G.; Schmitz, O.; Samm, U.; Stoschus, H.; Schulz, C.; Marot, L.; Romanyuk, A.; De Temmerman, G.; Laengner, M.; Breuer, U.; Stark, A.

    2011-01-01

    In future fusion devices like ITER deposition of impurities will likely occur in areas, remote from plasma and on the sensitive components of optical diagnostics, like mirrors and windows. Deposition in remote areas may lead to the tritium retention and therefore represent a safety issue. Deposition

  20. Implementation of the quality control of diagnostic monitors; Puesta en marcha del control de calidad de monitores de diagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Ramos Pacho, J. A.; Gomez Llorente, P. L.; Gomez Llorente, N.; Cons Perez, N.; Verde Velasco, J. M.; Perez Alvarez, M. E.; Delgado Aparicio, J. M.; Garcia Repiso, S.; Montes Fuentes, C.; Martin Rincon, C.

    2013-07-01

    The optimization of the quality of Radiology is aimed at obtaining greater diagnostic information minimizing the risks to the patient. This is essential, among other factors, not only that the image acquisition system works properly, but that the display device is capable of representing the information contained. (Author)

  1. Evaluation of the Quality Control Program for Diagnostic Radiography and Fluoroscopy Devices in Syria during 2005-2013

    Directory of Open Access Journals (Sweden)

    M. H. Kharita

    2017-06-01

    Full Text Available Introduction: Extensive use of diagnostic radiology is the largest contributor to total population radiation doses. Thus, appropriate equipment and safe practice are necessary for good-quality images with optimal doses. This study aimed to perform quality control (QC audit for radiography and fluoroscopy devices owned by private sector in Syria (2005-2013 to verify compliance of performance of X-ray machines with the regulatory requirements stipulated by the national regulatory body. Materials and Methods: In this study, QC audit included 487 X-ray diagnostic machines, (363 radiography and 124 fluoroscopy devices, installed in 306 medical diagnostic radiology centers in 14 provinces in Syria. We employed an X-ray beam analyzer device (NERO model 8000, Victoreen, USA, which was tested and calibrated at the National Secondary Standard Dosimetry Laboratory traceable to the IAEA Network of Secondary Standard Dosimetry Laboratories. Standard QC tool kits were used to evaluate tube and generator of the X-ray machines, which constituted potential (kVp, timer accuracy, radiation output consistency, tube filtration, small and large focal spot sizes, X-ray beam collimation and alignment, as well as high- and low-resolution and entrance surface dose in fluoroscopy. Results: According to our results, most of the assessed operating parameters were in compliance with the standards stipulated by the National Regulatory Authority. In cases of noncompliance for the assessed parameters, maximum value (28.77% pertained to accuracy of kVp calibration for radiography units, while the lowest value (2.42% belonged to entrance surface dose in fluoroscopy systems. Conclusion: Effective QC program in diagnostic radiology leads to obtaining information regarding quality of radiology devices used for medical diagnosis and minimizing the doses received by patients and medical personnel. The findings of this QC program, as the main part of QA program, illustrated that most

  2. [The practical experience of quality control organization in the laboratory of Municipal consultative diagnostic center 1 of St. Petersburg].

    Science.gov (United States)

    Ostroumova, M N; Mnuskina, M M

    2011-10-01

    The article specifies the functioning of quality control system in the laboratory of Municipal consultative diagnostic center i 1 of St. Petersburg. Initially, on the basis of interpretations of biological variations of every analyte, the requirements to analytical quality are developed. Subsequently, the actually attainable reproducibility of measurements and their bias is examined. The real analytical characteristics of 27 biochemical analytes are presented. The aggregate laboratory ratings are quoted based on the results of involvement in three EQAS programs since 2005, concerning biochemistry, immunochemistry and hematology. The important quality of laboratory research on its analytical stage is maintained by the interaction between inter-laboratory and regular external control.

  3. Pulmonary Embolism in Pneumonia: Still a Diagnostic Challenge? Results of a Case-Control Study in 100 Patients

    Directory of Open Access Journals (Sweden)

    Maria Paparoupa

    2016-01-01

    Full Text Available This study evaluated the diagnostic value of D-dimer, CRP, and leucocytes count to detect an underlying pulmonary embolism (PE in patients with pneumonia. A predictive model of an underlying PE, based on laboratory markers and clinical symptoms, was our ultimate objective. Overall 100 patients underwent a computed tomography angiography (CTA of the lung: 54 with coexistence of PE and pneumonia (cases and 46 with pneumonia without PE (controls. Cases and controls were matched 1 : 1. Symptoms and paraclinical findings were registered on admission. Receiver operating characteristic (ROC curves, search for an optimal threshold, and conditional logistic regression analysis were conducted. D-dimer has a moderate ability to detect PE in pneumonia. Sensitivity of D-dimer was estimated at 97.78% and specificity at 11.11%. No optimal cut-point has acceptable diagnostic ability. After excluding patients with sepsis, sensitivity was reduced to 96.97%, whereas specificity increased to 16.13%. Consolidation in chest X-ray and positive D-dimer predict better an underlying PE as D-dimer itself. Thus, discriminatory power of the prediction model (AUC of 0.740 is not much greater than D-dimer (AUC of 0.703. No threshold that could increase the diagnostic value of D-dimer or a prediction model which is significantly better than D-dimer itself was identified.

  4. Assessment of Augmented Electronic Fuel Controls for Modular Engine Diagnostics and Condition Monitoring

    Science.gov (United States)

    1978-12-01

    fault isolating eachi nono-FADE C 1700 LIMU. Of special interest is the obsor- vation that only 10 LlHt’s or 󈧎% 4re strong candidateos for fault...Systems ( EHMS ). These systems were previously utilized on Air Force T38 aircraft. In-flight data is stored In memory and transferred to PGSE postflight...VII of this report. Application of diagnostic and monitoring methods to an Army engine is a system problem with strong human factors overtones

  5. Diagnostics and Control of Natural Gas-Fired furnaces via Flame Image Analysis using Machine Vision & Artificial Intelligence Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Shahla Keyvan

    2005-12-01

    A new approach for the detection of real-time properties of flames is used in this project to develop improved diagnostics and controls for natural gas fired furnaces. The system utilizes video images along with advanced image analysis and artificial intelligence techniques to provide virtual sensors in a stand-alone expert shell environment. One of the sensors is a flame sensor encompassing a flame detector and a flame analyzer to provide combustion status. The flame detector can identify any burner that has not fired in a multi-burner furnace. Another sensor is a 3-D temperature profiler. One important aspect of combustion control is product quality. The 3-D temperature profiler of this on-line system is intended to provide a tool for a better temperature control in a furnace to improve product quality. In summary, this on-line diagnostic and control system offers great potential for improving furnace thermal efficiency, lowering NOx and carbon monoxide emissions, and improving product quality. The system is applicable in natural gas-fired furnaces in the glass industry and reheating furnaces used in steel and forging industries.

  6. Quality control in dental diagnostic radiology : anomalous in the use of radiological equipment; Control de Calidad en radiologia dental intraoral: anomalias en el funcionamiento de los equipos radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Alcaraz, M.; Martinez-Beneyto, Y.; Jodar, S.; Velasco, E.; Garcia-Vera, M. C.

    2004-07-01

    7,176 official quality control reports on dental diagnostic radiology were studied, relating to dental clinics located in 37 Spanish provinces covering 16 different autonomous Regions. The reports were issued as a result of the entry into force of Royal Decree 2071/1995 on quality control in General Diagnostic Radiology facilities, this Royal Decree was replaced by R. D. 1976/1999. The reports were writen by the UTPR (Technical Unit of Radiological Protection) Agsigma S. A. L., a company approved by the Nuclear Safety Council, and they correspond with the official reports issued during 1996-2001. This meants that a 5-year period has been monitored in order to observe the impacts of the establlishment of this legislation on quality control in intraoral dental diagnostic radiology facilities. The results show that 72.79% of the reports checked in 2001 would comply with the European Union's official recommendation (70 kVp, 8 mA> 1.5 mm of Al and 20 cm collimator length). Significant alterations have detected in a third (30.59%) of the radiological equipment. (Author) 36 refs.

  7. An investigation of infection control for x-ray cassettes in a diagnostic imaging department

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Matthew [School of Allied Health Professions and Science, Faculty of Health, Wellbeing and Science, University Campus Suffolk, Rope Walk, Ipswich, Suffolk, IP4 1LT (United Kingdom); Harvey, Jane M. [School of Allied Health Professions and Science, Faculty of Health, Wellbeing and Science, University Campus Suffolk, Rope Walk, Ipswich, Suffolk, IP4 1LT (United Kingdom)], E-mail: j.harvey@ucs.ac.uk

    2008-11-15

    Introduction: This research was conducted to investigate if X-ray cassettes could be a possible source of pathogens capable of causing nosocomial infections, and if they could be a possible vector for cross infection within the hospital environment. Method: The research involved the swabbing of X-ray cassettes in a Diagnostic Imaging Department of a large hospital in the east of England. Two areas of the Diagnostic Imaging Department were included in the study. Research concentrated on X-ray cassettes used for mobile radiography, accident and emergency and inpatient use. Forty cassettes were swabbed in total specifically for general levels of bacterial contamination, also for the presence or absence of methicillin-resistant Staphylococcus aureus (MRSA). A mapping exercise was completed following the location of an X-ray cassette typically used in mobile radiography. The exercise noted the level of direct contact with patient's skin and other possible routes of infection. Results: The results demonstrated that there were large levels of growth of samples taken from cassettes and developed in the Microbiology Department. Coagulase-negative Staphylococcus, Micrococci, Diptheroids and species of Bacillus were all identified. The mapping exercise in which the journey of a 35/43 cm cassette used for mobile radiography was tracked found that contact with patient's skin and potential pathogens or routes of cross infection was a common occurrence whilst undertaking mobile radiography. Conclusion: The research has identified the presence of bacterial contamination on cassettes. The research established that X-ray cassettes/imaging plates are often exposed to pathogens and possible routes of cross infection; also that patient's skin often comes directly in contact with the X-ray cassette/imaging plate. The research also shows that as cassettes/imaging plates are a potential source of cross infection, the Diagnostic Imaging Department may be partly responsible

  8. Routine internal- and external-quality control data in clinical laboratories for estimating measurement and diagnostic uncertainty using GUM principles.

    Science.gov (United States)

    Magnusson, Bertil; Ossowicki, Haakan; Rienitz, Olaf; Theodorsson, Elvar

    2012-05-01

    Healthcare laboratories are increasingly joining into larger laboratory organizations encompassing several physical laboratories. This caters for important new opportunities for re-defining the concept of a 'laboratory' to encompass all laboratories and measurement methods measuring the same measurand for a population of patients. In order to make measurement results, comparable bias should be minimized or eliminated and measurement uncertainty properly evaluated for all methods used for a particular patient population. The measurement as well as diagnostic uncertainty can be evaluated from internal and external quality control results using GUM principles. In this paper the uncertainty evaluations are described in detail using only two main components, within-laboratory reproducibility and uncertainty of the bias component according to a Nordtest guideline. The evaluation is exemplified for the determination of creatinine in serum for a conglomerate of laboratories both expressed in absolute units (μmol/L) and relative (%). An expanded measurement uncertainty of 12 μmol/L associated with concentrations of creatinine below 120 μmol/L and of 10% associated with concentrations above 120 μmol/L was estimated. The diagnostic uncertainty encompasses both measurement uncertainty and biological variation, and can be estimated for a single value and for a difference. This diagnostic uncertainty for the difference for two samples from the same patient was determined to be 14 μmol/L associated with concentrations of creatinine below 100 μmol/L and 14 % associated with concentrations above 100 μmol/L.

  9. Mycoplasma bovis pathogenesis, diagnostic methods and epidemiology of relevance for control and prevention

    DEFF Research Database (Denmark)

    Nielsen, Liza Rosenbaum

    routes are direct cattle-to-cattle contact, contaminated milk and milking equipment, and aerosols moving between animals over short distances (few meters), so any prevention method that can mitigate those routes will reduce the size and duration of outbreaks. Less common transmission routes include semen...... the herd becomes exposed to M. bovis - or new strains of M. bovis. Luckily this also has great benefits on the general health and production in cattle farms. The general prevention measures can to some extent be supported by diagnostic testing prior to movement of cattle, even though it is not possible...

  10. The Origination and Diagnostics of Uncaptured Beam in the Tevatron and Its Control by Electron Lenses

    CERN Document Server

    Zhang, Xiao-Long; Kamerdzhiev, Vsevolod; Lebedev, Valery; Shiltsev, Vladimir; Thurman-Keup, Randy; Tollestrup, Alvin V

    2008-01-01

    In the Collider Run II, the Tevatron operates with 36 high intensity bunches of 980 GeV protons and antiprotons. Particles not captured by the Tevatron RF system pose a threat to quench the superconducting magnet during acceleration or at beam abort. We describe the main mechanisms for the origination of this uncaptured beam, and present measurements of its main parameters by means of a newly developed diagnostics system. The Tevatron Electron Lens is effectively used in the Collider Run II operation to remove uncaptured beam and keep its intensity in the abort gaps at a safe level.

  11. Generation and diagnostics of uncaptured beam in the Fermilab Tevatron and its control by electron lenses

    Science.gov (United States)

    Zhang, Xiao-Long; Bishofberger, Kip; Kamerdzhiev, Vsevolod; Lebedev, Valery; Shiltsev, Vladimir; Thurman-Keup, Randy; Tollestrup, Alvin

    2008-05-01

    In the collider run II, the Tevatron operates with 36 high intensity bunches of 980 GeV protons and antiprotons. Particles not captured by the Tevatron rf system pose a threat since they can quench the superconducting magnets during acceleration or at beam abort. We describe the main mechanisms for the origination of this uncaptured beam, and present measurements of its main parameters by means of a newly developed diagnostics system. The Tevatron electron lens is effectively used in the collider run II operation to remove uncaptured beam and keep its intensity in the abort gaps at a safe level.

  12. Heating, Ventilating, and Air-Conditioning: Recent Advances in Diagnostics and Controls to Improve Air-Handling System Performance

    Energy Technology Data Exchange (ETDEWEB)

    Wray, Craig; Wray, Craig P.; Sherman, Max H.; Walker, I.S.; Dickerhoff, D.J.; Federspiel, C.C.

    2008-02-01

    The performance of air-handling systems in buildings needs to be improved. Many of the deficiencies result from myths and lore and a lack of understanding about the non-linear physical principles embedded in the associated technologies. By incorporating these principles, a few important efforts related to diagnostics and controls have already begun to solve some of the problems. This paper illustrates three novel solutions: one rapidly assesses duct leakage, the second configures ad hoc duct-static-pressure reset strategies, and the third identifies useful intermittent ventilation strategies. By highlighting these efforts, this paper seeks to stimulate new research and technology developments that could further improve air-handling systems.

  13. A diagnostic assessment of evolutionary algorithms for multi-objective surface water reservoir control

    Science.gov (United States)

    Zatarain Salazar, Jazmin; Reed, Patrick M.; Herman, Jonathan D.; Giuliani, Matteo; Castelletti, Andrea

    2016-06-01

    Globally, the pressures of expanding populations, climate change, and increased energy demands are motivating significant investments in re-operationalizing existing reservoirs or designing operating policies for new ones. These challenges require an understanding of the tradeoffs that emerge across the complex suite of multi-sector demands in river basin systems. This study benchmarks our current capabilities to use Evolutionary Multi-Objective Direct Policy Search (EMODPS), a decision analytic framework in which reservoirs' candidate operating policies are represented using parameterized global approximators (e.g., radial basis functions) then those parameterized functions are optimized using multi-objective evolutionary algorithms to discover the Pareto approximate operating policies. We contribute a comprehensive diagnostic assessment of modern MOEAs' abilities to support EMODPS using the Conowingo reservoir in the Lower Susquehanna River Basin, Pennsylvania, USA. Our diagnostic results highlight that EMODPS can be very challenging for some modern MOEAs and that epsilon dominance, time-continuation, and auto-adaptive search are helpful for attaining high levels of performance. The ɛ-MOEA, the auto-adaptive Borg MOEA, and ɛ-NSGAII all yielded superior results for the six-objective Lower Susquehanna benchmarking test case. The top algorithms show low sensitivity to different MOEA parameterization choices and high algorithmic reliability in attaining consistent results for different random MOEA trials. Overall, EMODPS poses a promising method for discovering key reservoir management tradeoffs; however algorithmic choice remains a key concern for problems of increasing complexity.

  14. Feedback control and beam diagnostic algorithms for a multiprocessor DSP system

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, D.; Claus, R.; Fox, J.; Hindi, H.; Linscott, I.; Prabhakar, S. [Stanford Linear Accelerator Center, P.O. Box 4349, Stanford, California 94309 (United States); Drago, A. [INFN---Laboratori Nazionali di Frascati, P.O. Box 13, I-00044 Frascati (Roma) (Italy); Stover, G. [Lawrence Berkeley Laboratory, 1 Cyclotron Road, Berkeley, California 94563 (United States)

    1997-01-01

    The multibunch longitudinal feedback system developed for use by PEP-II, ALS, and DA{Phi}NE uses a parallel array of digital signal processors (DSPs) to calculate the feedback signals from measurements of beam motion. The system is designed with general-purpose programmable elements which allow many feedback operating modes as well as system diagnostics, calibrations, and accelerator measurements. The overall signal processing architecture of the system is illustrated. The real-time DSP algorithms and off-line postprocessing tools are presented. The problems in managing 320k samples of data collected in one beam transient measurement are discussed and our solutions are presented. Example software structures are presented showing the beam feedback process, techniques for modal analysis of beam motion (used to quantify growth and damping rates of instabilities), and diagnostic functions (such as timing adjustment of beam pick-up and kicker components). These operating techniques are illustrated with example results obtained from the system installed at the Advanced Light Source at LBL. {copyright} {ital 1997 American Institute of Physics.}

  15. Feedback control and beam diagnostic algorithms for a multiprocessor DSP system

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, D.; Claus, R.; Fox, J.; Hindi, H.; Linscott, I.; Prabhakar, S. [Stanford Univ., CA (United States). Stanford Linear Accelerator Center; Drago, A. [INFN, Roma (Italy). Lab. Nazionali di Frascati; Stover, G. [Lawrence Berkeley Lab., CA (United States)

    1996-09-01

    The multibunch longitudinal feedback system developed for use by PEP-II, ALS and DA{Phi}NE uses a parallel array of digital signal processors to calculate the feedback signals from measurements of beam motion. The system is designed with general-purpose programmable elements which allow many feedback operating modes as well as system diagnostics, calibrations and accelerator measurements. The overall signal processing architecture of the system is illustrated. The real-time DSP algorithms and off-line postprocessing tools are presented. The problems in managing 320 K samples of data collected in one beam transient measurement are discussed and the solutions are presented. Example software structures are presented showing the beam feedback process, techniques for modal analysis of beam motion(used to quantify growth and damping rates of instabilities) and diagnostic functions (such as timing adjustment of beam pick-up and kicker components). These operating techniques are illustrated with example results obtained from the system installed at the Advanced Light Source at LBL.

  16. Optical property measurements as a diagnostic tool for control of materials processing in space and on Earth

    Science.gov (United States)

    Krishnan, Shankar; Weber, J. K. Richard; Nordine, Paul C.; Schiffman, Robert A.

    1990-01-01

    A new method is described, including results, to measure, control, and follow containerless processing in ground based levitators. This technique enables instantaneous optical property measurements from a transient solid or liquid surface concurrent with true temperature measurement. This was used successfully as a diagnostic tool to follow processing of Al, Si, and Ti during electromagnetic levitation. Experiments on Al show the disappearance of the oxide (emittance 0.33) at ca. 1300 C leaving a liquid surface with an emittance of 0.06. Electromagnetic levitation of silicon shows a liquid with a constant emittance (0.2) but with a solid whose emittance decreases very rapidly with increasing temperature. Consequently, the processing of materials at high temperatures can be controlled quite well through the control of surface optical properties.

  17. Epizootiological and diagnostic significance of porcine reproductive and respiratory syndrome control

    Directory of Open Access Journals (Sweden)

    Radojičić Biljana

    2002-01-01

    Full Text Available The porcine reproductive and respiratory syndrome (PRRS is a new viral disease in swine, designated exclusively under the acronym PRRS by the European Commission in 1991. The cause of this disease was isolated and determined in 1991 at the Lelystad Institute in The Netherlands as Lelystad aretrivirus. The PRRSV is an RNA virus of the order Nidovirales, the family Arteriviridae, the genus Arterivirus (Cavanaugh, 1997. Different genomic and pheriotypic varieties of the virus are significant. It is replicated in macrophages, it induces permanent viraemia, causes the creation of antibodies, and leads to persistent and latent infections. It is isolated from tonsil tissue, alveolar macrophages, the uterus, and fetal homogenate composed of different tissues (Wills et al., 1997. All production categories of swine can contract PRRS, but pregnant sows, suckling piglets and fattening swine are considered endangered categories. Morbidity and mortapty is between 8-80%, which also depends on the animal category. Economic damages are substantial when one considers the high percentage of still-born piglets, mummified fetuses and suckling piglets. Irregular successive cycles in sows are also expressed. In fattening swine, in addition to a respiratory form of the clinical picture, the time period until animals reach abattoir weight is extended even up to 30 days, which is also a considerable economic loss. Costs of treating possible secondary bacterial infections, diagnostics and immunoprophylaxis are not negligible. The OIE placed PRRS on the B list in 1992 as a contagious disease of swine which incurs economic losses in almost all countries of the world. Diagnosis is made by isolating and determining the virus and/or by serodiagnostics (ELISA and PCR. Certain countries have already made up protocols for the implementation of constant diagnostics and suggested eradication measures (Dee S.A. et al., 2000. In our country, the first clinical cases of PRRS were

  18. Developing evaluation instrument based on CIPP models on the implementation of portfolio assessment

    Science.gov (United States)

    Kurnia, Feni; Rosana, Dadan; Supahar

    2017-08-01

    This study aimed to develop an evaluation instrument constructed by CIPP model on the implementation of portfolio assessment in science learning. This study used research and development (R & D) method; adapting 4-D by the development of non-test instrument, and the evaluation instrument constructed by CIPP model. CIPP is the abbreviation of Context, Input, Process, and Product. The techniques of data collection were interviews, questionnaires, and observations. Data collection instruments were: 1) the interview guidelines for the analysis of the problems and the needs, 2) questionnaire to see level of accomplishment of portfolio assessment instrument, and 3) observation sheets for teacher and student to dig up responses to the portfolio assessment instrument. The data obtained was quantitative data obtained from several validators. The validators consist of two lecturers as the evaluation experts, two practitioners (science teachers), and three colleagues. This paper shows the results of content validity obtained from the validators and the analysis result of the data obtained by using Aikens' V formula. The results of this study shows that the evaluation instrument based on CIPP models is proper to evaluate the implementation of portfolio assessment instruments. Based on the experts' judgments, practitioners, and colleagues, the Aikens' V coefficient was between 0.86-1,00 which means that it is valid and can be used in the limited trial and operational field trial.

  19. Comprehensive analysis and differentiated assessment of food safety control systems: a diagnostic instrument

    NARCIS (Netherlands)

    Luning, P.A.; Bango, L.; Kussaga, J.; Rovira, J.; Marcelis, W.J.

    2008-01-01

    In this article, an instrument is presented to diagnose microbial safety control activities in a food safety management system. The need of such a tool is derived from the importance of microbial safety control and the need for improvement of existing control systems. Careful diagnosis of these syst

  20. Intermediate frequency band digitized high dynamic range radiometer system for plasma diagnostics and real-time Tokamak control

    Science.gov (United States)

    Bongers, W. A.; van Beveren, V.; Thoen, D. J.; Nuij, P. J. W. M.; de Baar, M. R.; Donné, A. J. H.; Westerhof, E.; Goede, A. P. H.; Krijger, B.; van den Berg, M. A.; Kantor, M.; Graswinckel, M. F.; Hennen, B. A.; Schüller, F. C.

    2011-06-01

    An intermediate frequency (IF) band digitizing radiometer system in the 100-200 GHz frequency range has been developed for Tokamak diagnostics and control, and other fields of research which require a high flexibility in frequency resolution combined with a large bandwidth and the retrieval of the full wave information of the mm-wave signals under investigation. The system is based on directly digitizing the IF band after down conversion. The enabling technology consists of a fast multi-giga sample analog to digital converter that has recently become available. Field programmable gate arrays (FPGA) are implemented to accomplish versatile real-time data analysis. A prototype system has been developed and tested and its performance has been compared with conventional electron cyclotron emission (ECE) spectrometer systems. On the TEXTOR Tokamak a proof of principle shows that ECE, together with high power injected and scattered radiation, becomes amenable to measurement by this device. In particular, its capability to measure the phase of coherent signals in the spectrum offers important advantages in diagnostics and control. One case developed in detail employs the FPGA in real-time fast Fourier transform (FFT) and additional signal processing. The major benefit of such a FFT-based system is the real-time trade-off that can be made between frequency and time resolution. For ECE diagnostics this corresponds to a flexible spatial resolution in the plasma, with potential application in smart sensing of plasma instabilities such as the neoclassical tearing mode (NTM) and sawtooth instabilities. The flexible resolution would allow for the measurement of the full mode content of plasma instabilities contained within the system bandwidth.

  1. Intermediate frequency band digitized high dynamic range radiometer system for plasma diagnostics and real-time Tokamak control

    Energy Technology Data Exchange (ETDEWEB)

    Bongers, W. A.; Beveren, V. van; Westerhof, E.; Goede, A. P. H.; Krijger, B.; Berg, M. A. van den; Graswinckel, M. F.; Schueller, F. C. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Thoen, D. J. [Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft (Netherlands); Nuij, P. J. W. M. [Eindhoven University of Technology, Control Systems Technology Group, and Applied Physics Department, PO Box 513, NL-5600 MB Eindhoven (Netherlands); Baar, M. R. de; Donne, A. J. H.; Hennen, B. A. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Eindhoven University of Technology, Control Systems Technology Group, and Applied Physics Department, PO Box 513, NL-5600 MB Eindhoven (Netherlands); Kantor, M. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Forschungszentrum Juelich GMBH, Institute of Energy and Climate research, Plasma Physics, Association EURATOM-FZJ, Trilateral Euregio Cluster, 52425 Juelich (Germany); Ioffe Institute, RAS, Saint-Petersburg, 195256 (Russian Federation)

    2011-06-15

    An intermediate frequency (IF) band digitizing radiometer system in the 100-200 GHz frequency range has been developed for Tokamak diagnostics and control, and other fields of research which require a high flexibility in frequency resolution combined with a large bandwidth and the retrieval of the full wave information of the mm-wave signals under investigation. The system is based on directly digitizing the IF band after down conversion. The enabling technology consists of a fast multi-giga sample analog to digital converter that has recently become available. Field programmable gate arrays (FPGA) are implemented to accomplish versatile real-time data analysis. A prototype system has been developed and tested and its performance has been compared with conventional electron cyclotron emission (ECE) spectrometer systems. On the TEXTOR Tokamak a proof of principle shows that ECE, together with high power injected and scattered radiation, becomes amenable to measurement by this device. In particular, its capability to measure the phase of coherent signals in the spectrum offers important advantages in diagnostics and control. One case developed in detail employs the FPGA in real-time fast Fourier transform (FFT) and additional signal processing. The major benefit of such a FFT-based system is the real-time trade-off that can be made between frequency and time resolution. For ECE diagnostics this corresponds to a flexible spatial resolution in the plasma, with potential application in smart sensing of plasma instabilities such as the neoclassical tearing mode (NTM) and sawtooth instabilities. The flexible resolution would allow for the measurement of the full mode content of plasma instabilities contained within the system bandwidth.

  2. Potential application of new diagnostic methods for controlling bovine Tuberculosis in Brazil

    Directory of Open Access Journals (Sweden)

    Luciana dos Santos Medeiros

    2010-10-01

    Full Text Available Bovine tuberculosis, a chronic infection in cattle caused by Mycobacterium bovis, remains an economic and public health problem for several countries. Due to its economic impact on international trade, contagious nature, and implications for human health, global programs to eradicate the disease were implemented worldwide. Those programs are based on slaughtering PPD-reactive animals. Despite the National Programs in Brazil, complete eradication has not been achieved, and the disease remains, albeit at a lower prevalence. The central purpose of this review is to address diagnostic tests for tuberculosis. Considering the course of the infection in cattle, at least two tests, ideally complementary to one another, may be necessary for an adequate diagnosis: the first based on the cellular response, and the second capable of identifying anergic animals by detection of specific anti-M.bovis antibodies.

  3. Advanced Neuropsychological Diagnostics Infrastructure (ANDI: A Normative Database Created from Control Datasets.

    Directory of Open Access Journals (Sweden)

    Nathalie R. de Vent

    2016-10-01

    Full Text Available In the Advanced Neuropsychological Diagnostics Infrastructure (ANDI, datasets of several research groups are combined into a single database, containing scores on neuropsychological tests from healthy participants. For most popular neuropsychological tests the quantity and range of these data surpasses that of traditional normative data, thereby enabling more accurate neuropsychological assessment. Because of the unique structure of the database, it facilitates normative comparison methods that were not feasible before, in particular those in which entire profiles of scores are evaluated. In this article, we describe the steps that were necessary to combine the separate datasets into a single database. These steps involve matching variables from multiple datasets, removing outlying values, determining the influence of demographic variables, and finding appropriate transformations to normality. Also, a brief description of the current contents of the ANDI database is given.

  4. Towards a Diagnostic Instrument to Identify Improvement Opportunities for Quality Controlled Logistics in Agrifood Supply Chain Networks

    Directory of Open Access Journals (Sweden)

    Jack G.A.J. van der Vorst

    2011-10-01

    Full Text Available  Western-European consumers have become not only more demanding on product availability in retail outlets but also on other food attributes such as quality, integrity, and safety. When (redesigning food supply-chain networks, from a logistics point of view, one has to consider these demands next to traditional efficiency and responsiveness requirements. The concept ‘quality controlled logistics’ (QCL hypothesizes that if product quality in each step of the supply chain can be predicted in advance, goods flows can be controlled in a pro-active manner and better chain designs can be established resulting in higher product availability, constant quality, and less product losses. The paper discusses opportunities of using real-time product quality information for improvement of the design and management of ‘AgriFood Supply Chain Networks’, and presents a preliminary diagnostic instrument for assessment of ‘critical quality’ and ‘logistics control’ points in the supply chain network. Results of a tomato-chain case illustrate the added value of the QCL concept for identifying improvement opportunities in the supply chain as to increase both product availability and quality. Future research aims for the further development of the diagnostic instrument and the quantification of costs and benefits of QCL scenarios.

  5. Internal quality control of PCR-based genotyping methods in research studies and patient diagnostics

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Gram, Jørgen; Jespersen, Jørgen

    2002-01-01

    Genetic analyses are increasingly integrated in the clinical laboratory, and internal quality control programmes are needed. We have focused on quality control aspects of selected polymorphism analyses used in thrombosis research. DNA was isolated from EDTA-blood (n = 500) by ammonium acetate pre...

  6. Controlling methicillin-resistant Staphylococcus aureus : Quantifying the effects of interventions and rapid diagnostic testing

    NARCIS (Netherlands)

    Bootsma, M.C.; Diekmann, O.; Bonten, M.J.M.

    2006-01-01

    Control of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) has been unsuccessful in most countries. Yet, some countries have maintained low endemic levels by implementing nationwide MRSA-specific infection control measures, such as ‘‘search & destroy’’ (S&D). These

  7. Primary central nervous system vasculitis and its mimicking diseases - clinical features, outcome, comorbidities and diagnostic results - A case control study.

    Science.gov (United States)

    Becker, J; Horn, P A; Keyvani, K; Metz, I; Wegner, C; Brück, W; Heinemann, F M; Schwitalla, J C; Berlit, P; Kraemer, M

    2017-05-01

    To compare clinical features and outcome, imaging characteristics, biopsy results and laboratory findings in a cohort of 69 patients with suspected or diagnosed primary central nervous system vasculitis (PCNSV) in adults; to identify risk factors and predictive features for PCNSV. We performed a case-control-study including 69 patients referred with suspected PCNSV from whom 25 were confirmed by predetermined diagnostic criteria based on biopsy (72%) or angiography (28%). Forty-four patients turned out to have 15 distinct other diagnoses. Clinical and diagnostic data were compared between PCNSV and Non-PCNSV cohorts. Clinical presentation was not able to discriminate between PCNSV and its differential diagnoses. However, a worse clinical outcome was associated with PCNSV (p=0.005). Biopsy (p=0.004), contrast enhancement (p=0.000) or tumour-like mass lesion (p=0.008) in magnetic resonance imaging (MRI), intrathecal IgG increase (p=0.020), normal Duplex findings of cerebral arteries (p=0.022) and conventional angiography (p 0.010) were able to distinguish between the two cohorts. In a cohort of 69 patients with suspected PCNSV, a large number (64%) was misdiagnosed and partly received treatment, since mimicking diseases are very difficult to discriminate. Clinical presentation at manifestation does not help to differentiate PCNSV from its mimicking diseases. MRI and cerebrospinal fluid analysis are unlikely to be normal in PCNSV, though unspecific if pathological. Cerebral angiography and biopsy must complement other diagnostics when establishing the diagnosis in order to avoid misdiagnosis and mistreatment. German clinical trials register: http://drks-neu.uniklinik-freiburg.de/drks_web/, Unique identifier: DRKS00005347. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Development and first applications of an OH reactivity instrument based on the Comparative Reactivity Method

    Science.gov (United States)

    Dusanter, S.; Michoud, V.; Hansen, R. F.; Leonardis, T.; Locoge, N.; Stevens, P. S.; Blocquet, M.; Schoemaecker, C.; Fittschen, C. M.; Zannoni, N.; Gros, V.; Sarda Esteve, R.; Sinha, V.

    2015-12-01

    Assessing the oxidative capacity of the atmosphere is important to address fundamental issues related to both air quality and climate change. However, recent measurements of total OH reactivity have highlighted an incomplete understanding of the hydroxyl radical (OH) budget, the main oxidizing agent in the atmosphere. This context has led to the development of several techniques for measuring total OH reactivity to better constrain atmospheric chemistry. This presentation will review the development of an OH reactivity instrument developed at Mines Douai, France. This instrument, based on the Comparative Reactivity Method (CRM), has been carefully characterized in the laboratory and has been compared to other OH reactivity instruments during two different field campaigns. These studies will be summarized to show that CRM instruments can perform reliable measurements in urban and remote areas providing that a few measurement artefacts are well characterized and accounted for during field campaigns.

  9. Automated system of control and diagnostics of cast-steel defects in the mass production

    Science.gov (United States)

    Knyazev, S. V.; Usoltsev, A. A.; Skopich, D. V.; Fatyanova, E. A.; Dolgopolov, A. E.

    2016-09-01

    To solve the problem of efficient control over technological process in the foundry the mathematical model is required, that would connect the the input and output parameters of the object. To collect the data on cast-steels defects an automated system was developed that greatly simplifies the process of technical control and allows the problem of process parameters optimization to be solved using the criterion of defects minimization in the cast- steels.

  10. Concept for the real-time control and data acquisition of the W7X diagnostic injector (RudiX)

    Energy Technology Data Exchange (ETDEWEB)

    Lambertz, H. [Institute for Energy Research - Plasma Physics, Julich (Germany); Richert, T. [Max-Planck-Institute for Plasma Physics, Greifswald (Germany)

    2009-07-01

    This document is composed of a poster and its abstract. The Russian diagnostics injector for Wendelstein 7-X (RudiX) is built within the scope of an international cooperation by 3 associations (FZJ-IEF-4 1, IPP-HGW 2, BINP 3). With respect to the large distance between the partner institutes and the huge number of interfaces at the injector side a modular, decentralized concept became necessary. It has to fulfill the requirements regarding the operation modes as well as local boundary conditions (limited access to the experiment). The control system based on S7 300/400 series by Siemens and for programming and visualisation environment the Step 7 and WinCC software packages are used. Connection to other systems and sub-systems of the diagnostics injector are realised by standardised interfaces, using the following protocols: professional bus DP and Ethernet TCP-IP. The concept is separated in two parts: a) an interfaces to the W7-X main control and b) an internal subsystem interfaces. For the internal set-up several independent PLC 4 or decentralized peripheral modules with separate Cpu are used according to the safety requirements (fault-tolerant Cpu and peripheral). The data acquisition modules allowing connections to XDV 5 and to the PLC at the same. Following this modular and decentralized set-up it is possible to develop and apply standardised and re-usable software components allowing the operation of sub-systems independently from the complete system. For the connection to the central W7-X main control an interface simulator will be developed to test the functionality during the project phase independently. (authors)

  11. Can Rapid Diagnostic Testing for Malaria Increase Adherence to Artemether-Lumefantrine?: A Randomized Controlled Trial in Uganda.

    Science.gov (United States)

    Saran, Indrani; Yavuz, Elif; Kasozi, Howard; Cohen, Jessica

    2016-04-01

    Most patients with suspected malaria do not receive diagnostic confirmation before beginning antimalarial treatment. We investigated the extent to which uncertainty about malaria diagnosis contributes to patient nonadherence to artemether-lumefantrine (AL) treatment through a randomized controlled trial in central Uganda. Among 1,525 patients purchasing a course of AL at private drug shops, we randomly offered 37.6% a free malaria rapid diagnostic test (RDT) and then assessed adherence through home visits 3 days later. Of these subjects, 68.4% tested positive for malaria and 65.8% adhered overall. Patients who tested positive did not have significantly higher odds of adherence than those who were not offered the test (adjusted odds ratio [OR]: 1.07, 95% confidence interval [CI]: 0.734-1.57,P= 0.719). Patients who received a positive malaria test had 0.488 fewer pills remaining than those not offered the test (95% CI: -1.02 to 0.043,P= 0.072). We found that patients who felt relatively healthy by the second day of treatment had lower odds of completing treatment (adjusted OR: 0.532, 95% CI: 0.394-0.719,Psymptoms have resolved.

  12. Diagnostic performance of the Bernese versus Ottawa ankle rules: Results of a randomised controlled trial.

    Science.gov (United States)

    Derksen, Robert J; Knijnenberg, Lisa M; Fransen, Gerwin; Breederveld, Roelf S; Heymans, Martijn W; Schipper, Inger B

    2015-08-01

    The Ottawa ankle rules (OAR) brought about a reduction of radiographs on the Emergency Department (ED). However, still 50% of patients with ankle injuries undergo unnecessary radiography. Compared to the OAR, the Bernese ankle rule (BAR) has an acclaimed 84% reduction in radiography without loss of sensitivity. The primary aim of this study was to compare the diagnostic accuracy and reproducibility of both rules. Furthermore, the ability of triage nurses to accurately interpret the BAR was assessed. Participants were assessed by both the ED resident and the triage nurse, applying the OAR and the BAR. After standardised data collection, ankle and foot radiographs were performed in all patients. Sensitivity and specificity of both tests applied by both observers were obtained and compared by McNemar's test. Reproducibility was calculated with Cohen's kappa. A total of 203 patients with ankle trauma were included. For the OAR obtained by the ED residents, the sensitivity and specificity were 0.97 and 0.29, respectively. For the BAR, the sensitivity and specificity of the ED residents were 0.69 and 0.45, respectively. For the triage nurses, the OAR sensitivity and specificity were 0.86 and 0.25, respectively. The BAR sensitivity and specificity for the nurses were 0.86 and 0.40, respectively. The reproducibility of the OAR was 0.45, and for the BAR, it was 0.48. Both rules showed comparable reproducibility. Although the BAR showed a superior specificity compared to the OAR, its sensitivity was too low to promote clinical use. The triage nurses demonstrated too low sensitivity on both rules to allow safe application. Therefore, the OAR remain the decision rules of choice for ankle injuries despite its modest 'ruling out' capacity. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Applicability of Proposed Diagnostic Criteria of Pityriasis Rosea: Results of a Prospective Case-Control Study in India

    Science.gov (United States)

    Zawar, Vijay; Chuh, Antonio

    2013-01-01

    Background: The diagnosis of pityriasis rosea (PR) is generally clinical. Previous studies usually recruited relatively small numbers of patients and control subjects, leading to low power of study results. Systematic reviews and meta-analyses cannot be readily performed, as the inclusion and exclusion criteria of these studies were not uniform. We have previously validated a set of diagnostic criteria (DC) in Chinese patients with PR. Aim: Our aim is to evaluate the validity and applicability of the DC of PR in Indian patients with PR. Study Design: Prospective unblinded pair-matched case-control study. Materials and Methods: The setting is a dermatology clinic in India served by one board-certified dermatologist. We recruited all 88 patients seen by us during five years diagnosed to have PR to join our study. For each study subject, we recruited the next patient who consulted us with differential diagnoses of PR as control subjects. We applied the DC of PR on all study and control subjects. Result: The sensitivity, specificity, positive predictive value, and negative predictive value of the DC were all 100%. Two-tailed Fisher's exact probability test result was 0.036. Φ was 1.00. Conclusion: The set of DC can be validly applied to Indian patients with PR. PMID:24249894

  14. Wireless Infrastructure for Performing Monitoring, Diagnostics, and Control HVAC and Other Energy-Using Systems in Small Commercial Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Patrick O' Neill

    2009-06-30

    This project focused on developing a low-cost wireless infrastructure for monitoring, diagnosing, and controlling building systems and equipment. End users receive information via the Internet and need only a web browser and Internet connection. The system used wireless communications for: (1) collecting data centrally on site from many wireless sensors installed on building equipment, (2) transmitting control signals to actuators and (3) transmitting data to an offsite network operations center where it is processed and made available to clients on the Web (see Figure 1). Although this wireless infrastructure can be applied to any building system, it was tested on two representative applications: (1) monitoring and diagnostics for packaged rooftop HVAC units used widely on small commercial buildings and (2) continuous diagnosis and control of scheduling errors such as lights and equipment left on during unoccupied hours. This project developed a generic infrastructure for performance monitoring, diagnostics, and control, applicable to a broad range of building systems and equipment, but targeted specifically to small to medium commercial buildings (an underserved market segment). The proposed solution is based on two wireless technologies. The first, wireless telemetry, is used for cell phones and paging and is reliable and widely available. This risk proved to be easily managed during the project. The second technology is on-site wireless communication for acquiring data from sensors and transmitting control signals. The technology must enable communication with many nodes, overcome physical obstructions, operate in environments with other electrical equipment, support operation with on-board power (instead of line power) for some applications, operate at low transmission power in license-free radio bands, and be low cost. We proposed wireless mesh networking to meet these needs. This technology is relatively new and has been applied only in research and tests

  15. Information and diagnostic tools of objective control as means to improve performance of mining machines

    Science.gov (United States)

    Zvonarev, I. E.; Shishlyannikov, D. I.

    2017-02-01

    The paper justifies the relevance of developing and implementing automated onboard systems for operation data and maintenance recording in heading-and-winning machines. The analysis of advantages and disadvantages of existing automated onboard systems for operation data and maintenance recording in heading-and-winning machines for potassium mines are presented. The basic technical requirements for the design, operating algorithms and functions of recording systems of mining machines for potassium mines are formulated. A method of controlling operating parameters is presented; the concept of the onboard automated recording system for the Ural heading-and-winning machine is outlined. The results of experimental studies of variations in loading of the Ural-20R miner’s operating member drives, using the VATUR portable measuring complex, are given. It is proved that existing means of objective control of operating parameters of the URAL-20R heading-and-winning machine do not assure its optimal operation. The authors present a technique of analyzing the data provided by parameter recorders that allow increasing efficiency of mechanical complexes by determining numerical values characterizing the technical and technological level of potassium ore production organization. The efficiency assessment criteria for engineering and maintenance departments of mining enterprises are advanced. A technology of continuous automated monitoring of potassium mine’s outburst hazard is described.

  16. Diagnostic value of the copper/zinc ratio in digestive cancer: a case control study.

    Science.gov (United States)

    Poo, J L; Romero, R R; Robles, J A; Montemayor, A C; Isoard, F; Estanes, A; Uribe, M

    1997-01-01

    The aim of this study was to assess the accuracy of the copper/zinc ratio (Cu/Zn ratio) in the evaluation of a large group of patients with digestive cancer compared to gender and age-matched control subjects. A total of 282 patients was studied and separated into three groups: group I (n = 75), patients with digestive cancer, group II (n = 112), patients with benign digestive disease, and group III (n = 95), healthy subjects. Serum levels of copper and zinc were measured by atomic absorption spectrophotometry. The results showed that the serum levels of copper (mg/dL) in patients with digestive cancer (91.6 +/- 27.3, p cancer (1.45 +/- .58, p copper/zinc ratio was 82.2%, with a specificity of 65.7%, a positive predictive value of 45.8% and a negative predictive value of 91.3%. In conclusion, Cu/Zn ratio was found to be considerably higher in patients with digestive cancer compared to age- and gender-matched controls, with a sensitivity of 82.2% that might be useful in the evaluation of suspected malignancy.

  17. MO-AB-210-00: Diagnostic Ultrasound Imaging Quality Control and High Intensity Focused Ultrasound Therapy Hands-On Workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The goal of this ultrasound hands-on workshop is to demonstrate advancements in high intensity focused ultrasound (HIFU) and to demonstrate quality control (QC) testing in diagnostic ultrasound. HIFU is a therapeutic modality that uses ultrasound waves as carriers of energy. HIFU is used to focus a beam of ultrasound energy into a small volume at specific target locations within the body. The focused beam causes localized high temperatures and produces a well-defined regions of necrosis. This completely non-invasive technology has great potential for tumor ablation and targeted drug delivery. At the workshop, attendees will see configurations, applications, and hands-on demonstrations with on-site instructors at separate stations. The involvement of medical physicists in diagnostic ultrasound imaging service is increasing due to QC and accreditation requirements. At the workshop, an array of ultrasound testing phantoms and ultrasound scanners will be provided for attendees to learn diagnostic ultrasound QC in a hands-on environment with live demonstrations of the techniques. Target audience: Medical physicists and other medical professionals in diagnostic imaging and radiation oncology with interest in high-intensity focused ultrasound and in diagnostic ultrasound QC. Learning Objectives: Learn ultrasound physics and safety for HIFU applications through live demonstrations Get an overview of the state-of-the art in HIFU technologies and equipment Gain familiarity with common elements of a quality control program for diagnostic ultrasound imaging Identify QC tools available for testing diagnostic ultrasound systems and learn how to use these tools List of supporting vendors for HIFU and diagnostic ultrasound QC hands-on workshop: Philips Healthcare Alpinion Medical Systems Verasonics, Inc Zonare Medical Systems, Inc Computerized Imaging Reference Systems (CIRS), Inc. GAMMEX, Inc., Cablon Medical BV Steffen Sammet: NIH/NCI grant 5R25CA132822, NIH/NINDS grant 5R25NS

  18. Presentation of Diagnostic Information to Doctors May Change Their Interpretation and Clinical Management: A Web-Based Randomised Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Yoav Ben-Shlomo

    Full Text Available There is little evidence on how best to present diagnostic information to doctors and whether this makes any difference to clinical management. We undertook a randomised controlled trial to see if different data presentations altered clinicians' decision to further investigate or treat a patient with a fictitious disorder ("Green syndrome" and their ability to determine post-test probability.We recruited doctors registered with the United Kingdom's largest online network for medical doctors between 10 July and 6" November 2012. Participants were randomised to one of four arms: (a text summary of sensitivity and specificity, (b Fagan's nomogram, (c probability-modifying plot (PMP, (d natural frequency tree (NFT. The main outcome measure was the decision whether to treat, not treat or undertake a brain biopsy on the hypothetical patient and the correct post-test probability. Secondary outcome measures included knowledge of diagnostic tests.917 participants attempted the survey and complete data were available from 874 (95.3%. Doctors randomized to the PMP and NFT arms were more likely to treat the patient than those randomized to the text-only arm. (ORs 1.49, 95% CI 1.02, 2.16 and 1.43, 95% CI 0.98, 2.08 respectively. More patients randomized to the PMP (87/218-39.9% and NFT (73/207-35.3% arms than the nomogram (50/194-25.8% or text only (30/255-11.8% arms reported the correct post-test probability (p <0.001. Younger age, postgraduate training and higher self-rated confidence all predicted better knowledge performance. Doctors with better knowledge were more likely to view an optional learning tutorial (OR per correct answer 1.18, 95% CI 1.06, 1.31.Presenting diagnostic data using a probability-modifying plot or natural frequency tree influences the threshold for treatment and improves interpretation of tests results compared to text summary of sensitivity and specificity or Fagan's nomogram.

  19. Prognostic and diagnostic value of moderate intensity stress test with blood pressure control

    Directory of Open Access Journals (Sweden)

    V. N. Marchenko

    2014-01-01

    Full Text Available In spite of age and blood pressure values at rest,hypertensive response to moderate intensity stress testingis characterized by increasing ofprobable beginning of cardiac infarction, stroke or coronary disease in 1.36 times. The hypertensive response to stress test in people with normal blood pressure values at rest (independent of other risk factors is characterized by increasing risk of future hypertension more than in 2 times. Antihypertensive drugs affect blood pressure values differently during the stress testing. The prognosis of blood pressure values during daily physical activity is necessary for antihypertensive treatment. Low availability of convenient instruments and methodological tools for continuous measurement of blood pressure (similar to Spiroarteriocardiorhythmograph, Finapres duringthe dosed physical loads constrain wide use of stress tests with controlled blood pressure in medical practice.

  20. Spectral finite element method wave propagation, diagnostics and control in anisotropic and inhomogeneous structures

    CERN Document Server

    Gopalakrishnan, Srinivasan; Roy Mahapatra, Debiprosad

    2008-01-01

    The use of composites and Functionally Graded Materials (FGMs) in structural applications has increased. FGMs allow the user to design materials for a specified functionality and have many uses in structural engineering. However, the behaviour of these structures under high-impact loading is not well understood. This book is the first to apply the Spectral Finite Element Method (SFEM) to inhomogeneous and anisotropic structures in a unified and systematic manner. It focuses on some of the problems with this media which were previously thought unmanageable. Types of SFEM for regular and damaged 1-D and 2-D waveguides, solution techniques, methods of detecting the presence of damages and their locations, and methods for controlling the wave propagation responses are discussed. Tables, figures and graphs support the theory and case studies are included. This book is of value to senior undergraduates and postgraduates studying in this field, and researchers and practicing engineers in structural integrity.

  1. Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.

    Science.gov (United States)

    Bun Teoh, Anthony Yuen; Ning Chong, Charing Ching; Wa Leung, Wing; Cheong Chan, Simon Kin; Kit Tse, Yee; Wai Ng, Enders Kwok; San Lai, Paul Bo; Yuen Wu, Justin Che; Wong Lau, James Yun

    2017-07-24

    The role of electroacupuncture (EA) in reducing sedative and analgesic requirements during EUS is uncertain. The aim of the current study is to investigate the efficacy of EA in reducing procedure-related pain and discomfort during EUS. This was a double-blinded randomized controlled study conducted between March 2014 and July 2016. Consecutive patients who were scheduled for diagnostic EUS were recruited and randomized to receive electroacupuncture (EA) or sham-electroacupuncture (SA). The primary outcome was the dosage of propofol used. Other outcome measurements included pain scores, anxiety scores, satisfaction scores, patients' willingness to repeat the procedure, total procedure time, and adverse events. One hundred twenty-eight patients were recruited to the study. The patients that received EA had significantly fewer PCA requirements. The median (IQR range) number of demands for PCA (2 [1 - 5] vs 16.5 [8.5 - 33.8], P<0.001), the number of successful demands (2 [1 - 4] vs 9 [5.3 - 13], P<0.001), the total dose of propofol (0.15 [0.08 - 0.34] vs 0.77 [0.38 - 1.09], P<0.001) and alfentanil (0.38 [0.20 - 0.86] vs 1.92 [0.94 - 2.72], P<0.001) were all significantly less. Patients that received EA also had significantly less procedural pain scores and anxiety scores (P<0.001), higher satisfaction scores (P<0.001), and they are more willing to repeat the procedure (P<0.001). Both being in the SA group and the procedural time were significant predictors to increased PCA demands (P < 0.001 and P = 0.009 respectively). In conclusion, the use of EA reduced sedative and analgesic demands, improved patient experience, and was associated with low risk of adverse events during diagnostic EUS. Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  2. Quality control procedures of dental diagnostic radiology systems; Elaboracao de um procedimento para controle de qualidade em sistemas de radiodiagnostico odontologico

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Paula Serra Sasaki

    2007-07-01

    This work presents quality control reference procedures for dental diagnostic radiology systems, following the recommendations of the Publication 453 of the Brazilian Health Ministry (PF453), to be applied in dental clinics, in order to achieve an improvement in the radiological image qualities and the patient dose reduction. All tests were applied in an intraoral X rays system, following the methodology developed and the requirements of the PF 453. In order to verify the best quality of the image in relation to the smaller exposition time an object test was also developed in this work. The use of this object allowed the reduction of the exposition time of 0.5 seconds, the maximum value of the linear region of the characteristic curve, for 0.2 seconds. The tested X rays system showed a very good agreement with the applied procedures, detaching the reduction of the skin entrance dose using the film-holding devices. However, the size of the field increased and exceeded the maximum value of 6 cm recommended in the standard. The importance of the quality control in dental diagnostic radiology systems is essential due to the constant use of X radiation in dental clinics. The PF453 recommends the frequency of at least two years for the constancy tests. However, it is suggested that the professional, surgeon-dentist, should be responsible for the internal control of the image quality obtained from the X rays device. This can be done through monthly exposures of the object test developed in this work. (author)

  3. Consistency of Field-Based Measures of Neuromuscular Control Using Force-Plate Diagnostics in Elite Male Youth Soccer Players.

    Science.gov (United States)

    Read, Paul J; Oliver, Jon L; Croix, Mark Ba De Ste; Myer, Gregory D; Lloyd, Rhodri S

    2016-12-01

    Read, P, Oliver, JL, Croix, MD, Myer, GD, and Lloyd, RS. Consistency of field-based measures of neuromuscular control using force-plate diagnostics in elite male youth soccer players. J Strength Cond Res 30(12): 3304-3311, 2016-Deficits in neuromuscular control during movement patterns such as landing are suggested pathomechanics that underlie sport-related injury. A common mode of assessment is measurement of landing forces during jumping tasks; however, these measures have been used less frequently in male youth soccer players, and reliability data are sparse. The aim of this study was to examine the reliability of a field-based neuromuscular control screening battery using force-plate diagnostics in this cohort. Twenty-six pre-peak height velocity (PHV) and 25 post-PHV elite male youth soccer players completed a drop vertical jump (DVJ), single-leg 75% horizontal hop and stick (75%HOP), and single-leg countermovement jump (SLCMJ). Measures of peak landing vertical ground reaction force (pVGRF), time to stabilization, time to pVGRF, and pVGRF asymmetry were recorded. A test-retest design was used, and reliability statistics included change in mean, intraclass correlation coefficient, and coefficient of variation (CV). No significant differences in mean score were reported for any of the assessed variables between test sessions. In both groups, pVGRF and asymmetry during the 75%HOP and SLCMJ demonstrated largely acceptable reliability (CV ≤ 10%). Greater variability was evident in DVJ pVGRF and all other assessed variables, across the 3 protocols (CV range = 13.8-49.7%). Intraclass correlation coefficient values ranged from small to large and were generally higher in the post-PHV players. The results of this study suggest that pVGRF and asymmetry can be reliably assessed using a 75%HOP and SLCMJ in this cohort. These measures could be used to support a screening battery for elite male youth soccer players and for test-retest comparison.

  4. Real-time combustion control and diagnostics sensor-pressure oscillation monitor

    Science.gov (United States)

    Chorpening, Benjamin T.; Thornton, Jimmy; Huckaby, E. David; Richards, George A.

    2009-07-14

    An apparatus and method for monitoring and controlling the combustion process in a combustion system to determine the amplitude and/or frequencies of dynamic pressure oscillations during combustion. An electrode in communication with the combustion system senses hydrocarbon ions and/or electrons produced by the combustion process and calibration apparatus calibrates the relationship between the standard deviation of the current in the electrode and the amplitudes of the dynamic pressure oscillations by applying a substantially constant voltage between the electrode and ground resulting in a current in the electrode and by varying one or more of (1) the flow rate of the fuel, (2) the flow rate of the oxidant, (3) the equivalence ratio, (4) the acoustic tuning of the combustion system, and (5) the fuel distribution in the combustion chamber such that the amplitudes of the dynamic pressure oscillations in the combustion chamber are calculated as a function of the standard deviation of the electrode current. Thereafter, the supply of fuel and/or oxidant is varied to modify the dynamic pressure oscillations.

  5. Neonatal Diagnostics: Towards Dynamic Growth Charts of Neuro-motor control

    Directory of Open Access Journals (Sweden)

    Elizabeth B Torres

    2016-11-01

    Full Text Available Current rise of neurodevelopmental disorders, poses a critical need to detect risk early in order to rapidly intervene. One of the tools Pediatricians use to track development is the standard Growth Chart. The Growth Charts are somewhat limited in predicting possible neurodevelopmental issues. They rely on linear models and assumptions of normality for physical growth data —obscuring key statistical information about possible neurodevelopmental risk in growth data that actually has accelerated, non-linear rates-of-change and variability encompassing skewed distributions. Here we use new analytics to profile growth data from 36 newborn babies that were tracked longitudinally for 5 months. By switching to incremental (velocity-based growth charts and combining these dynamic changes with underlying fluctuations in motor performance—as they transition from spontaneous random noise to a systematic signal— we demonstrate a method to detect very early stunting in the development of voluntary neuro-motor control and to flag risk of neurodevelopmental derail.

  6. Real-time combustion control and diagnostics sensor-pressure oscillation monitor

    Science.gov (United States)

    Chorpening, Benjamin T.; Thornton, Jimmy; Huckaby, E. David; Richards, George A.

    2009-07-14

    An apparatus and method for monitoring and controlling the combustion process in a combustion system to determine the amplitude and/or frequencies of dynamic pressure oscillations during combustion. An electrode in communication with the combustion system senses hydrocarbon ions and/or electrons produced by the combustion process and calibration apparatus calibrates the relationship between the standard deviation of the current in the electrode and the amplitudes of the dynamic pressure oscillations by applying a substantially constant voltage between the electrode and ground resulting in a current in the electrode and by varying one or more of (1) the flow rate of the fuel, (2) the flow rate of the oxidant, (3) the equivalence ratio, (4) the acoustic tuning of the combustion system, and (5) the fuel distribution in the combustion chamber such that the amplitudes of the dynamic pressure oscillations in the combustion chamber are calculated as a function of the standard deviation of the electrode current. Thereafter, the supply of fuel and/or oxidant is varied to modify the dynamic pressure oscillations.

  7. First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans".

    Science.gov (United States)

    Alvarez Rojas, Cristian A; Fredes, Fernando; Torres, Marisa; Acosta-Jamett, Gerardo; Alvarez, Juan Francisco; Pavletic, Carlos; Paredes, Rodolfo; Cortés, Sandra

    2016-09-13

    This report summarizes the outcomes of a meeting on cystic echinococcosis (CE) in animals and humans in Chile held in Santiago, Chile, between the 21st and 22nd of January 2016. The meeting participants included representatives of the Departamento de Zoonosis, Ministerio de Salud (Zoonotic Diseases Department, Ministry of Health), representatives of the Secretarias Regionales del Ministerio de Salud (Regional Department of Health, Ministry of Health), Instituto Nacional de Desarrollo Agropecuario (National Institute for the Development of Agriculture and Livestock, INDAP), Instituto de Salud Pública (National Institute for Public Health, ISP) and the Servicio Agrícola y Ganadero (Animal Health Department, SAG), academics from various universities, veterinarians and physicians. Current and future CE control activities were discussed. It was noted that the EG95 vaccine was being implemented for the first time in pilot control programmes, with the vaccine scheduled during 2016 in two different regions in the South of Chile. In relation to use of the vaccine, the need was highlighted for acquiring good quality data, based on CE findings at slaughterhouse, previous to initiation of vaccination so as to enable correct assessment of the efficacy of the vaccine in the following years. The current world's-best-practice concerning the use of ultrasound as a diagnostic tool for the screening population in highly endemic remote and poor areas was also discussed.

  8. Efficacy of labral repair, biceps tenodesis, and diagnostic arthroscopy for SLAP Lesions of the shoulder: a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Mowinckel Petter

    2010-10-01

    Full Text Available Abstract Background Surgery for type II SLAP (superior labral anterior posterior lesions of the shoulder is a promising but unproven treatment. The procedures include labral repair or biceps tenodesis. Retrospective cohort studies have suggested that the benefits of tenodesis include pain relief and improved function, and higher patient satisfaction, which was reported in a prospective non-randomised study. There have been no completed randomised controlled trials of surgery for type II SLAP lesions. The aims of this participant and observer blinded randomised placebo-controlled trial are to compare the short-term (6 months and long-term (2 years efficacy of labral repair, biceps tenodesis, and placebo (diagnostic arthroscopy for alleviating pain and improving function for type II SLAP lesions. Methods/Design A double-blind randomised controlled trial are performed using 120 patients, aged 18 to 60 years, with a history for type II SLAP lesions and clinical signs suggesting type II SLAP lesion, which were documented by MR arthrography and arthroscopy. Exclusion criteria include patients who have previously undergone operations for SLAP lesions or recurrent shoulder dislocations, and ruptures of the rotator cuff or biceps tendon. Outcomes will be assessed at baseline, three, six, 12, and 24 months. Primary outcome measures will be the clinical Rowe Score (1988-version and the Western Ontario Instability Index (WOSI at six and 24 months. Secondary outcome measures will include the Shoulder Instability Questionnaire (SIQ, the generic EuroQol (EQ-5 D and EQ-VAS, return to work and previous sports activity, complications, and the number of reoperations. Discussion The results of this trial will be of international importance and the results will be translatable into clinical practice. Trial Registration [ClinicalTrials.gov NCT00586742

  9. Effects of a web-based decision aid regarding diagnostic self-testing. A single-blind randomized controlled trial

    NARCIS (Netherlands)

    Ickenroth, M.H.; Grispen, J.E.; Vries, N.K. de; Dinant, G.J.; Ronda, G.; Weijden, T.T. van der

    2016-01-01

    Currently, there are many diagnostic self-tests on body materials available to consumers. The aim of this study was to assess the effect of an online decision aid on diagnostic self-testing for cholesterol and diabetes on knowledge among consumers with an intention to take these tests. A randomized

  10. The Development of Physics Learning Instrument Based on Hypermedia and Its Influence on the Student Problem Solving Skill

    Science.gov (United States)

    Amin, Bunga Dara; Mahmud, Alimuddin; Muris

    2016-01-01

    This research aims to produce a learning instrument based on hypermedia which is valid, interesting, practical, and effective as well as to know its influence on the problem based skill of students Mathematical and Science Faculty, Makassar State University. This research is a research and development at (R&D) type. The development procedure…

  11. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study.

    NARCIS (Netherlands)

    Jenab, M.; Bueno De Mesquita, H.B.; Ferrari, P.; Duijnhoven, F.J.B. van; Norat, T.; Pischon, T.; Jansen, E.H.; Slimani, N.; Byrnes, G.; Rinaldi, S.; Tjonneland, A.; Olsen, A.; Overvad, K.; Boutron-Ruault, M.C.; Clavel-Chapelon, F.; Morois, S.; Kaaks, R.; Linseisen, J.; Boeing, H.; Bergmann, M.M.; Trichopoulou, A.; Misirli, G.; Trichopoulos, D.; Berrino, F.; Vineis, P.; Panico, S.; Palli, D.; Tumino, R.; Ros, M.M.; Gils, C.H. van; Peeters, P.H.M.; Brustad, M.; Lund, E.; Tormo, M.J.; Ardanaz, E.; Rodriguez, L.; Sanchez, M.J.; Dorronsoro, M.; Gonzalez, C.A.; Hallmans, G.; Palmqvist, R.; Roddam, A.; Key, T.J.; Khaw, K.T.; Autier, P.; Hainaut, P.; Riboli, E.

    2010-01-01

    OBJECTIVE: To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. DESIGN: Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of

  12. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations : a nested case-control study

    NARCIS (Netherlands)

    Jenab, Mazda; Bueno-de-Mesquita, H. Bas; Ferrari, Pietro; van Duijnhoven, Franzel J. B.; Norat, Teresa; Pischon, Tobias; Jansen, Eugene H. J. M.; Slimani, Nadia; Byrnes, Graham; Rinaldi, Sabina; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Morois, Sophie; Kaaks, Rudolf; Linseisen, Jakob; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Misirli, Gesthimani; Trichopoulos, Dimitrios; Berrino, Franco; Vineis, Paolo; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Ros, Martine M.; van Gils, Carla H.; Peeters, Petra H.; Brustad, Magritt; Lund, Eiliv; Tormo, Maria-Jose; Ardanaz, Eva; Rodriguez, Laudina; Sanchez, Maria-Jose; Dorronsoro, Miren; Gonzalez, Carlos A.; Hallmans, Goeran; Palmqvist, Richard; Roddam, Andrew; Key, Timothy J.; Khaw, Kay-Tee; Autier, Philippe; Hainaut, Pierre; Riboli, Elio

    2010-01-01

    Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. Design Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of

  13. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations : a nested case-control study

    NARCIS (Netherlands)

    Jenab, Mazda; Bueno-de-Mesquita, H. Bas; Ferrari, Pietro; van Duijnhoven, Franzel J. B.; Norat, Teresa; Pischon, Tobias; Jansen, Eugene H. J. M.; Slimani, Nadia; Byrnes, Graham; Rinaldi, Sabina; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Morois, Sophie; Kaaks, Rudolf; Linseisen, Jakob; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Misirli, Gesthimani; Trichopoulos, Dimitrios; Berrino, Franco; Vineis, Paolo; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Ros, Martine M.; van Gils, Carla H.; Peeters, Petra H.; Brustad, Magritt; Lund, Eiliv; Tormo, Maria-Jose; Ardanaz, Eva; Rodriguez, Laudina; Sanchez, Maria-Jose; Dorronsoro, Miren; Gonzalez, Carlos A.; Hallmans, Goeran; Palmqvist, Richard; Roddam, Andrew; Key, Timothy J.; Khaw, Kay-Tee; Autier, Philippe; Hainaut, Pierre; Riboli, Elio

    2010-01-01

    Objective To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. Design Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of mo

  14. On-line integration of computer controlled diagnostic devices and medical information systems in undergraduate medical physics education for physicians.

    Science.gov (United States)

    Hanus, Josef; Nosek, Tomas; Zahora, Jiri; Bezrouk, Ales; Masin, Vladimir

    2013-01-01

    We designed and evaluated an innovative computer-aided-learning environment based on the on-line integration of computer controlled medical diagnostic devices and a medical information system for use in the preclinical medical physics education of medical students. Our learning system simulates the actual clinical environment in a hospital or primary care unit. It uses a commercial medical information system for on-line storage and processing of clinical type data acquired during physics laboratory classes. Every student adopts two roles, the role of 'patient' and the role of 'physician'. As a 'physician' the student operates the medical devices to clinically assess 'patient' colleagues and records all results in an electronic 'patient' record. We also introduced an innovative approach to the use of supportive education materials, based on the methods of adaptive e-learning. A survey of student feedback is included and statistically evaluated. The results from the student feedback confirm the positive response of the latter to this novel implementation of medical physics and informatics in preclinical education. This approach not only significantly improves learning of medical physics and informatics skills but has the added advantage that it facilitates students' transition from preclinical to clinical subjects.

  15. Cost-effectiveness of malaria microscopy and rapid diagnostic tests versus presumptive diagnosis: implications for malaria control in Uganda

    Directory of Open Access Journals (Sweden)

    Batwala Vincent

    2011-12-01

    Full Text Available Abstract Background Current Uganda National Malaria treatment guidelines recommend parasitological confirmation either by microscopy or rapid diagnostic test (RDT before treatment with artemether-lumefantrine (AL. However, the cost-effectiveness of these strategies has not been assessed at rural operational primary care centres. Methods Three health centres (HCs were randomized to three diagnostic arms (microscopy, RDT and presumptive diagnosis in a district of low and another of high malaria transmission intensities in Uganda. Some 22,052 patients presenting with fever at outpatients departments were enrolled from March 2010 to February 2011. Of these, a random sample of 1,627 was selected to measure additional socio-economic characteristics. Costing was performed following the standard step-down cost allocation and the ingredients approach. Effectiveness was measured as the number and proportion of patients correctly diagnosed and treated. Incremental Cost-Effectiveness Ratios (ICERs were estimated from the societal perspective (http://Clinicaltrials.gov, NCT00565071. Results Overall RDT was most cost-effective with lowest ICER US$5.0 compared to microscopy US$9.61 per case correctly diagnosed and treated. In the high transmission setting, ICER was US$4.38 for RDT and US$12.98 for microscopy. The corresponding ICERs in the low transmission setting were US$5.85 and US$7.63 respectively. The difference in ICERs between RDT and microscopy was greater in the high transmission area (US$8.9 than in low transmission setting (US$1.78. At a willingness to pay of US$2.8, RDT remained cost effective up to a threshold value of the cost of treatment of US$4.7. Conclusion RDT was cost effective in both low and high transmission settings. With a global campaign to reduce the costs of AL and RDT, the Malaria Control Programme and stakeholders need a strategy for malaria diagnosis because as the cost of AL decreases, presumptive treatment is likely to become

  16. New developments at JET in diagnostics, real-time control, data acquisition and information retrieval with potential application to ITER

    Energy Technology Data Exchange (ETDEWEB)

    Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Avda. Complutense, 22, 28040 Madrid (Spain)], E-mail: jesus.vega@ciemat.es; Murari, A. [Associazione EURATOM-ENEA per la Fusione, Consorzio RFX, 4-35127 Padova (Italy); Carvalho, B. [CFN, Associacao IST/EURATOM, 1049-001 Lisboa (Portugal); Arcas, G. de [Grupo de Investigacion en Instrumentacion y Acustica Aplicada, Universidad Politecnica de Madrid, Crta. Valencia Km 7, 28031, Madrid (Spain); Felton, R. [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Riva, M. [Associazione EURATOM-ENEA sulla Fusione, C.R. Frascati, C.P. 65, I-00044 Frascati (Italy); Ruiz, M. [Grupo de Investigacion en Instrumentacion y Acustica Aplicada, Universidad Politecnica de Madrid, Crta. Valencia Km 7, 28031, Madrid (Spain); Svensson, J. [Max-Planck-Institut fuer Plasmaphysik, Teilinstitut Greifswald, EURATOM Association, Wendelsteinstr. 1, 17491 Greifswald (Germany)

    2009-12-15

    In magnetic confinement fusion, the operation of next generation devices will be significantly different compared to present day machines. The duration length of the discharges will require abandoning the traditional paradigm of processing and storing the data after the shot. In fact most information will have to be made available in real-time. The significant issues of machine protection will require more sophisticated and at the same time more robust feedback control schemes. Another very important issue emerged in the last years of JET operation, and which is expected to become more severe in ITER, is the large amount of data to be analysed, which cannot be handled in the most efficient way with traditional methods. In order to prepare for the operation of ITER, some tests are being performed at JET. The capacity of the real-time network has increased in the last years, and many more systems, mainly diagnostics have been connected to it in order to test their reliability and to assess the quality of the information they can provide for feedback control. To reduce the amount of data, a prototype of real-time adaptive data acquisition techniques is being implemented, to adjust the acquisition frequency to the time resolution of the phenomena to be analysed in the plasma. Lossless data compression techniques have been refined and various intelligent signal processing methods have already been implemented to allow an easier and more objective first screening of the data. To allow scientists from wide and diffuse communities to participate in the scientific and technical programme, various innovative tools for remote participation and experimentation are also being actively investigated.

  17. Wireless Infrastructure for Performing Monitoring, Diagnostics, and Control HVAC and Other Energy-Using Systems in Small Commercial Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Patrick O' Neill

    2009-06-30

    This project focused on developing a low-cost wireless infrastructure for monitoring, diagnosing, and controlling building systems and equipment. End users receive information via the Internet and need only a web browser and Internet connection. The system used wireless communications for: (1) collecting data centrally on site from many wireless sensors installed on building equipment, (2) transmitting control signals to actuators and (3) transmitting data to an offsite network operations center where it is processed and made available to clients on the Web (see Figure 1). Although this wireless infrastructure can be applied to any building system, it was tested on two representative applications: (1) monitoring and diagnostics for packaged rooftop HVAC units used widely on small commercial buildings and (2) continuous diagnosis and control of scheduling errors such as lights and equipment left on during unoccupied hours. This project developed a generic infrastructure for performance monitoring, diagnostics, and control, applicable to a broad range of building systems and equipment, but targeted specifically to small to medium commercial buildings (an underserved market segment). The proposed solution is based on two wireless technologies. The first, wireless telemetry, is used for cell phones and paging and is reliable and widely available. This risk proved to be easily managed during the project. The second technology is on-site wireless communication for acquiring data from sensors and transmitting control signals. The technology must enable communication with many nodes, overcome physical obstructions, operate in environments with other electrical equipment, support operation with on-board power (instead of line power) for some applications, operate at low transmission power in license-free radio bands, and be low cost. We proposed wireless mesh networking to meet these needs. This technology is relatively new and has been applied only in research and tests

  18. Internal control for real-time polymerase chain reaction based on MS2 bacteriophage for RNA viruses diagnostics

    Directory of Open Access Journals (Sweden)

    Miriam Ribas Zambenedetti

    Full Text Available BACKGROUND Real-time reverse transcription polymerase chain reaction (RT-PCR is routinely used to detect viral infections. In Brazil, it is mandatory the use of nucleic acid tests to detect hepatitis C virus (HCV, hepatitis B virus and human immunodeficiency virus in blood banks because of the immunological window. The use of an internal control (IC is necessary to differentiate the true negative results from those consequent from a failure in some step of the nucleic acid test. OBJECTIVES The aim of this study was the construction of virus-modified particles, based on MS2 bacteriophage, to be used as IC for the diagnosis of RNA viruses. METHODS The MS2 genome was cloned into the pET47b(+ plasmid, generating pET47b(+-MS2. MS2-like particles were produced through the synthesis of MS2 RNA genome by T7 RNA polymerase. These particles were used as non-competitive IC in assays for RNA virus diagnostics. In addition, a competitive control for HCV diagnosis was developed by cloning a mutated HCV sequence into the MS2 replicase gene of pET47b(+-MS2, which produces a non-propagating MS2 particle. The utility of MS2-like particles as IC was evaluated in a one-step format multiplex real-time RT-PCR for HCV detection. FINDINGS We demonstrated that both competitive and non-competitive IC could be successfully used to monitor the HCV amplification performance, including the extraction, reverse transcription, amplification and detection steps, without compromising the detection of samples with low target concentrations. In conclusion, MS2-like particles generated by this strategy proved to be useful IC for RNA virus diagnosis, with advantage that they are produced by a low cost protocol. An attractive feature of this system is that it allows the construction of a multicontrol by the insertion of sequences from more than one pathogen, increasing its applicability for diagnosing different RNA viruses.

  19. Transfer from point-of-care Ultrasonography training to diagnostic performance on patients-a randomized controlled trial

    DEFF Research Database (Denmark)

    Todsen, Tobias; Jensen, Morten Lind; Tolsgaard, Martin Grønnebæk

    2016-01-01

    BACKGROUND: Clinicians are increasingly using point-of-care ultrasonography for bedside examinations of patients. However, proper training is needed in this technique, and it is unknown whether the skills learned from focused Ultrasonography courses are being transferred to diagnostic performance...

  20. Effect of new tuberculosis diagnostic technologies on community-based intensified case finding: a multicentre randomised controlled trial.

    Science.gov (United States)

    Calligaro, Gregory L; Zijenah, Lynn S; Peter, Jonathan G; Theron, Grant; Buser, Virginia; McNerney, Ruth; Bara, Wilbert; Bandason, Tsitsi; Govender, Ureshnie; Tomasicchio, Michele; Smith, Liezel; Mayosi, Bongani M; Dheda, Keertan

    2017-04-01

    Inadequate case detection results in high levels of undiagnosed tuberculosis in sub-Saharan Africa. Data for the effect of new diagnostic tools when used for community-based intensified case finding are not available, so we investigated whether the use of sputum Xpert-MTB/RIF and the Determine TB LAM urine test in two African communities could be effective. In a pragmatic, randomised, parallel-group trial with individual randomisation stratified by country, we compared sputum Xpert-MTB/RIF, and if HIV-infected, the Determine TB LAM urine test (novel diagnostic group), with laboratory-based sputum smear microscopy (routine diagnostic group) for intensified case finding in communities with high tuberculosis and HIV prevalence in Cape Town, South Africa, and Harare, Zimbabwe. Participants were randomly assigned (1:1) to these groups with computer-generated allocation lists, using culture as the reference standard. In Cape Town, participants were randomised and tested at an Xpert-equipped mobile van, while in Harare, participants were driven to a local clinic where the same diagnostic tests were done. The primary endpoint was the proportion of culture-positive tuberculosis cases initiating tuberculosis treatment in each study group at 60 days. This trial is registered at ClinicalTrials.gov, number NCT01990274. Between Oct 18, 2013, and March 31, 2015, 2261 individuals were screened and 875 (39%) of these met the criteria for diagnostic testing. 439 participants were randomly assigned to the novel group and 436 to the routine group. 74 (9%) of 875 participants had confirmed tuberculosis. If late culture-based treatment initiation was excluded, more patients with culture-positive tuberculosis were initiated on treatment in the novel group at 60 days (36 [86%] of 42 in the novel group vs 18 [56%] of 32 in the routine group). Thus the difference in the proportion initiating treatment between groups was 29% (95% CI 9-50, p=0·0047) and 53% more patients initiated therapy in

  1. A real-time laser feedback control method for the three-wave laser source used in the polarimeter-interferometer diagnostic on Joint-TEXT tokamak.

    Science.gov (United States)

    Xiong, C Y; Chen, J; Li, Q; Liu, Y; Gao, L

    2014-12-01

    A three-wave laser polarimeter-interferometer, equipped with three independent far-infrared laser sources, has been developed on Joint-TEXT (J-TEXT) tokamak. The diagnostic system is capable of high-resolution temporal and phase measurement of the Faraday angle and line-integrated density. However, for long-term operation (>10 min), the free-running lasers can lead to large drifts of the intermediate frequencies (∼100-∼500 kHz/10 min) and decay of laser power (∼10%-∼20%/10 min), which act to degrade diagnostic performance. In addition, these effects lead to increased maintenance cost and limit measurement applicability to long pulse/steady state experiments. To solve this problem, a real-time feedback control method of the laser source is proposed. By accurately controlling the length of each laser cavity, both the intermediate frequencies and laser power can be simultaneously controlled: the intermediate frequencies are controlled according to the pre-set values, while the laser powers are maintained at an optimal level. Based on this approach, a real-time feedback control system has been developed and applied on J-TEXT polarimeter-interferometer. Long-term (theoretically no time limit) feedback of intermediate frequencies (maximum change less than ±12 kHz) and laser powers (maximum relative power change less than ±7%) has been successfully achieved.

  2. A real-time laser feedback control method for the three-wave laser source used in the polarimeter-interferometer diagnostic on Joint-TEXT tokamak

    Science.gov (United States)

    Xiong, C. Y.; Chen, J.; Li, Q.; Liu, Y.; Gao, L.

    2014-12-01

    A three-wave laser polarimeter-interferometer, equipped with three independent far-infrared laser sources, has been developed on Joint-TEXT (J-TEXT) tokamak. The diagnostic system is capable of high-resolution temporal and phase measurement of the Faraday angle and line-integrated density. However, for long-term operation (>10 min), the free-running lasers can lead to large drifts of the intermediate frequencies (˜100-˜500 kHz/10 min) and decay of laser power (˜10%-˜20%/10 min), which act to degrade diagnostic performance. In addition, these effects lead to increased maintenance cost and limit measurement applicability to long pulse/steady state experiments. To solve this problem, a real-time feedback control method of the laser source is proposed. By accurately controlling the length of each laser cavity, both the intermediate frequencies and laser power can be simultaneously controlled: the intermediate frequencies are controlled according to the pre-set values, while the laser powers are maintained at an optimal level. Based on this approach, a real-time feedback control system has been developed and applied on J-TEXT polarimeter-interferometer. Long-term (theoretically no time limit) feedback of intermediate frequencies (maximum change less than ±12 kHz) and laser powers (maximum relative power change less than ±7%) has been successfully achieved.

  3. Radiation safety and quality control assurance in X-ray diagnostics 1998; Saeteilyturvallisuus ja laadunvarmistus roentgendiagnostiikassa 1998

    Energy Technology Data Exchange (ETDEWEB)

    Servomaa, A. [ed.

    1998-03-01

    The report is based on a seminar course of lectures `Radiation safety and quality assurance in X-ray diagnostics 1998` organized by the Radiation and Nuclear Safety Authority (STUK) in Finland. The lectures included actual information on X-ray examinations: methods of quality assurance, methods of measuring and calculating patient doses, examination frequencies, patient doses, occupational doses, and radiation risks. Paediatric X-ray examinations and interventional procedures were the most specific topics. The new Council Directive 97/43/Euratom on medical exposure, and the European Guidelines on quality criteria for diagnostic radiographic images, were discussed in several lectures. Lectures on general radiation threats and preparedness, examples of radiation accidents, and emergency preparedness in hospitals were also included. (editor)

  4. Effect of Supervised Students' Involvement on Diagnostic Accuracy in Hospitalized Medical Patients — A Prospective Controlled Study

    Science.gov (United States)

    Herter, Dorothea Adelheid; Wagner, Robert; Holderried, Friederike; Fenik, Yelena; Riessen, Reimer; Weyrich, Peter; Celebi, Nora

    2012-01-01

    Background During internships most medical students engage in history taking and physical examination during evaluation of hospitalized patients. However, the students' ability for pattern recognition is not as developed as in medical experts and complete history taking is often not repeated by an expert, so important clues may be missed. On the other hand, students' history taking is usually more extensive than experts' history taking and medical students discuss their findings with a Supervisor. Thus the effect of student involvement on diagnostic accuracy is unclear. We therefore compared the diagnostic accuracy for patients in the medical emergency department with and without student involvement in the evaluation process. Methodology/Principal Findings Patients in the medical emergency department were assigned to evaluation by either a supervised medical student or an emergency department physician. We only included patients who were admitted to our hospital and subsequently cared for by another medical team on the ward. We compared the working diagnosis from the emergency department with the discharge diagnosis. A total of 310 patients included in the study were cared for by 41 medical students and 21 emergency department physicians. The working diagnosis was changed in 22% of the patients evaluated by physicians evaluation and in 10% of the patients evaluated by supervised medical students (p = .006). There was no difference in the expenditures for diagnostic procedures, length of stay in the emergency department or patient comorbidity complexity level. Conclusion/Significance Involvement of closely supervised medical students in the evaluation process of hospitalized medical patients leads to an improved diagnostic accuracy compared to evaluation by an emergency department physician alone. PMID:22984578

  5. Effect of supervised students' involvement on diagnostic accuracy in hospitalized medical patients--a prospective controlled study.

    Directory of Open Access Journals (Sweden)

    Dorothea Adelheid Herter

    Full Text Available BACKGROUND: During internships most medical students engage in history taking and physical examination during evaluation of hospitalized patients. However, the students' ability for pattern recognition is not as developed as in medical experts and complete history taking is often not repeated by an expert, so important clues may be missed. On the other hand, students' history taking is usually more extensive than experts' history taking and medical students discuss their findings with a Supervisor. Thus the effect of student involvement on diagnostic accuracy is unclear. We therefore compared the diagnostic accuracy for patients in the medical emergency department with and without student involvement in the evaluation process. METHODOLOGY/PRINCIPAL FINDINGS: Patients in the medical emergency department were assigned to evaluation by either a supervised medical student or an emergency department physician. We only included patients who were admitted to our hospital and subsequently cared for by another medical team on the ward. We compared the working diagnosis from the emergency department with the discharge diagnosis. A total of 310 patients included in the study were cared for by 41 medical students and 21 emergency department physicians. The working diagnosis was changed in 22% of the patients evaluated by physicians evaluation and in 10% of the patients evaluated by supervised medical students (p = .006. There was no difference in the expenditures for diagnostic procedures, length of stay in the emergency department or patient comorbidity complexity level. CONCLUSION/SIGNIFICANCE: Involvement of closely supervised medical students in the evaluation process of hospitalized medical patients leads to an improved diagnostic accuracy compared to evaluation by an emergency department physician alone.

  6. Conscious sedation during diagnostic endoscopic ultrasonography: A randomized, double-blind, controlled trial comparing midazolam with placebo

    OpenAIRE

    OĞUZ, Dilek; KÖKSAL, Aydın Şeref; ÇİÇEK, Bahattin; PARLAK, Erkan; ŞAHİN, Burhan

    2005-01-01

    Background/aim: There is no consensus regarding the application of conscious sedation in endoscopic procedures. In this prospective study we aimed to determine the necessity of applying sedation in diagnostic endoscopic ultrasonography. Materials and methods: Eighty patients who underwent endoscopic ultrasonography in Türkiye Yüksek İhtisas Hospital Gastroenterology Clinic were included in the study. Patients were separated into three groups depending on the region examined: esophagus ...

  7. Specialized rheumatology nurse substitutes for rheumatologists in the diagnostic process of fibromyalgia: a cost-consequence analysis and a randomized controlled trial.

    Science.gov (United States)

    Kroese, Mariëlle E; Severens, Johan L; Schulpen, Guy J; Bessems, Monique C; Nijhuis, Frans J; Landewé, Robert B

    2011-07-01

    To perform a cost-consequence analysis of the substitution of specialized rheumatology nurses (SRN) for rheumatologists (RMT) in the diagnostic process of fibromyalgia (FM), using both a healthcare and societal perspective and a 9-month period. Alongside a randomized controlled trial, we measured costs and consequences of a nurse-led diagnostic consult (SRN group, n = 97) versus a rheumatologist-led diagnostic consult [usual care (UC) group, n = 96]. Patients were followed for 9 months. Every second month a questionnaire on medical consumption and social participation was filled out. Satisfaction was measured 1 week after the first consultation. During followup, health status was measured by health-related quality of life (EQ-5D), functional status (Fibromyalgia Impact Questionnaire), fatigue (Checklist Individual Strength), and self-efficacy (Generalized Self-Efficacy Scale). Patients in the SRN group were significantly more satisfied. Improvements in health status were similar in both groups after 9 months of followup. Total costs for healthcare consumption and patient and family costs were significantly lower in the SRN group (€1298 vs €1644; difference €346; 95% CI -€746 to -€2). Total societal costs were €3853 per patient for the SRN group and €5293 for the UC group after 9 months of followup (difference €1440; 95% CI -€3721 to €577). From both a healthcare and societal perspective, the nurse-led diagnostic process can be recommended. Patients in the SRN group were significantly more satisfied, improvements in health status were similar in both groups, and total societal costs were lower for the SRN group compared to the RMT group after 9 months' followup. Registered with Current Controlled Trials, no. ISRCTN77212411.

  8. Prototype Positive Control Wells for Malaria Rapid Diagnostic Tests: Prospective Evaluation of Implementation Among Health Workers in Lao People's Democratic Republic and Uganda.

    Science.gov (United States)

    Bell, David; Bwanika, John Baptist; Cunningham, Jane; Gatton, Michelle; González, Iveth J; Hopkins, Heidi; Kibira, Simon Peter S; Kyabayinze, Daniel J; Mayxay, Mayfong; Ndawula, Bbaale; Newton, Paul N; Phommasone, Koukeo; Streat, Elizabeth; Umlauf, René

    2017-02-08

    Rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but lack of quality control at point of care restricts trust in test results. Prototype positive control wells (PCW) containing recombinant malaria antigens have been developed to identify poor-quality RDT lots. This study assessed community and facility health workers' (HW) ability to use PCWs to detect degraded RDTs, the impact of PCW availability on RDT use and prescribing, and preferred strategies for implementation in Lao People's Democratic Republic (Laos) and Uganda. A total of 557 HWs participated in Laos (267) and Uganda (290). After training, most (88% to ≥ 99%) participants correctly performed the six key individual PCW steps; performance was generally maintained during the 6-month study period. Nearly all (97%) reported a correct action based on PCW use at routine work sites. In Uganda, where data for 127,775 individual patients were available, PCW introduction in health facilities was followed by a decrease in antimalarial prescribing for RDT-negative patients ≥ 5 years of age (4.7-1.9%); among community-based HWs, the decrease was 12.2% (P malaria-endemic areas are able to use prototype PCWs for quality control of malaria RDTs. PCW availability can improve HWs' confidence in RDT results, and benefit malaria diagnostic programs. Lessons learned from this study may be valuable for introduction of other point-of-care diagnostic and quality-control tools. Future work should evaluate longer term impacts of PCWs on patient management. © The American Society of Tropical Medicine and Hygiene.

  9. Prototype Positive Control Wells for Malaria Rapid Diagnostic Tests: Prospective Evaluation of Implementation Among Health Workers in Lao People's Democratic Republic and Uganda

    Science.gov (United States)

    Bell, David; Bwanika, John Baptist; Cunningham, Jane; Gatton, Michelle; González, Iveth J.; Hopkins, Heidi; Kibira, Simon Peter S.; Kyabayinze, Daniel J.; Mayxay, Mayfong; Ndawula, Bbaale; Newton, Paul N.; Phommasone, Koukeo; Streat, Elizabeth; Umlauf, René

    2017-01-01

    Rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but lack of quality control at point of care restricts trust in test results. Prototype positive control wells (PCW) containing recombinant malaria antigens have been developed to identify poor-quality RDT lots. This study assessed community and facility health workers' (HW) ability to use PCWs to detect degraded RDTs, the impact of PCW availability on RDT use and prescribing, and preferred strategies for implementation in Lao People's Democratic Republic (Laos) and Uganda. A total of 557 HWs participated in Laos (267) and Uganda (290). After training, most (88% to ≥ 99%) participants correctly performed the six key individual PCW steps; performance was generally maintained during the 6-month study period. Nearly all (97%) reported a correct action based on PCW use at routine work sites. In Uganda, where data for 127,775 individual patients were available, PCW introduction in health facilities was followed by a decrease in antimalarial prescribing for RDT-negative patients ≥ 5 years of age (4.7–1.9%); among community-based HWs, the decrease was 12.2% (P < 0.05) for all patients. Qualitative data revealed PCWs as a way to confirm RDT quality and restore confidence in RDT results. HWs in malaria-endemic areas are able to use prototype PCWs for quality control of malaria RDTs. PCW availability can improve HWs' confidence in RDT results, and benefit malaria diagnostic programs. Lessons learned from this study may be valuable for introduction of other point-of-care diagnostic and quality-control tools. Future work should evaluate longer term impacts of PCWs on patient management. PMID:27895267

  10. A hybrid Bayesian hierarchical model combining cohort and case-control studies for meta-analysis of diagnostic tests: Accounting for partial verification bias.

    Science.gov (United States)

    Ma, Xiaoye; Chen, Yong; Cole, Stephen R; Chu, Haitao

    2014-05-26

    To account for between-study heterogeneity in meta-analysis of diagnostic accuracy studies, bivariate random effects models have been recommended to jointly model the sensitivities and specificities. As study design and population vary, the definition of disease status or severity could differ across studies. Consequently, sensitivity and specificity may be correlated with disease prevalence. To account for this dependence, a trivariate random effects model had been proposed. However, the proposed approach can only include cohort studies with information estimating study-specific disease prevalence. In addition, some diagnostic accuracy studies only select a subset of samples to be verified by the reference test. It is known that ignoring unverified subjects may lead to partial verification bias in the estimation of prevalence, sensitivities, and specificities in a single study. However, the impact of this bias on a meta-analysis has not been investigated. In this paper, we propose a novel hybrid Bayesian hierarchical model combining cohort and case-control studies and correcting partial verification bias at the same time. We investigate the performance of the proposed methods through a set of simulation studies. Two case studies on assessing the diagnostic accuracy of gadolinium-enhanced magnetic resonance imaging in detecting lymph node metastases and of adrenal fluorine-18 fluorodeoxyglucose positron emission tomography in characterizing adrenal masses are presented.

  11. A multicenter case-control study of diagnostic tests for urinary tract infection in the presence of urolithiasis.

    Science.gov (United States)

    Yilmaz, S; Pekdemir, M; Aksu, N M; Koyuncu, N; Cinar, O; Akpinar, E

    2012-02-01

    Urinary stone disease (USD) alone can cause much morbidity, but when present in conjunction with urinary tract infection, complications and morbidity increase even more. This study investigated the clinical and laboratory findings in patients who had USD with and without infection and evaluated the most suitable diagnostic value for urinary tract infection parameters before urine culture results were available. In a prospective fashion, patients who presented to the emergency department with a complaint of colicky flank pain (with or without hematuria) and who were diagnosed as having urolithiasis with ultrasound were evaluated for 1 year. The gold standard for the diagnosis of urinary tract infection was urine culture. The most suitable diagnostic value for urinary tract infection parameters was determined by receiver operating characteristic (ROC) curves. Logistic regression was used to identify independent variables that predicted a positive urine culture. Of the 192 eligible patients, 177 agreed to participate in the study. Of the clinical and laboratory characteristics analyzed, urine WBC, blood WBC, and fever were significantly different between culture positive and negative patients (p 11,300 (OR 2.1), pyuria (OR 2.8), and temperature >37.9°C (OR 3.1) showed a significantly increased risk of having a positive urine culture (correct class 87.9%). While a single physical examination or laboratory finding cannot predict urinary tract infection in USD patients with complete reliability, the presence of pyruria, fever, and leukocytosis significantly increases the odds of a positive urine culture.

  12. [Development of chlorophyll concentration nondestructive measurement instrument based on spectral analysis technology].

    Science.gov (United States)

    Li, Qing-Bo; Xu, Yu-Po; Zhang, Chao-Hang; Zhang, Guang-Jun; Wu, Jin-Guang

    2009-10-01

    A portable nondestructive measuring instrument for plant chlorophyll was developed, which can perform real-time, quick and nondestructive measurement of chlorophyll. The instrument is mainly composed of four parts, including leaves clamp, driving circuit of light source, photoelectric detection and signal conditioning circuit and micro-control system. A new scheme of light source driving was proposed, which can not only achieve constant current, but also control the current by digital signal. The driving current can be changed depending on different light source and measurement situation by actual operation, which resolves the matching problem of output intensity of light source and input range of photoelectric detector. In addition, an integrative leaves clamp was designed, which simplified the optical structure, enhanced the stability of apparatus, decreased the loss of incident light and improved the signal-to-noise ratio and precision. The photoelectric detection and signal conditioning circuit achieve the conversion between optical signal and electrical signal, and make the electrical signal meet the requirement of AD conversion, and the photo detector is S1133-14 of Hamamatsu Company, with a high detection precision. The micro-control system mainly achieves control function, dealing with data, data storage and so on. As the most important component, microprocessor MSP430F149 of TI Company has many advantages, such as high processing speed, low power, high stability and so on. And it has an in-built 12 bit AD converter, so the data-acquisition circuit is simpler. MSP430F149 is suitable for portable instrument. In the calibration experiment of the instrument, the standard value was measured by chlorophyll meter SPAD-502, multiple linear calibration models were built, and the instrument performance was evaluated. The correlation coefficient between chlorophyll prediction value and standard value is 0.97, and the root mean square error of prediction is about 1

  13. Astrovirus Diagnostics

    Science.gov (United States)

    Pérot, Philippe; Lecuit, Marc; Eloit, Marc

    2017-01-01

    Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised individuals in association with central nervous system (CNS) infections. This work reviews the past and current methods for astrovirus detection and their uses in both research laboratories and for medical diagnostic purposes. PMID:28085120

  14. An Inclusion Instrument Based on Planned Behavior Theory for Prospective Physical Educators.

    Science.gov (United States)

    Kudláèek, Martin; Válková, Hana; Sherrill, Claudine; Myers, Bettye; French, Ron

    2002-07-01

    The purpose was to provide validity evidence for an attitude survey that will predict the intention of Czech prospective teachers to include students with physical disabilities in general physical education (GPE). Based on the theory of planned behavior (Ajzen, 1991, 2000), the Czech Attitude Toward Teaching Individuals with Physical Disabilities in Physical Education (ATIPDPE) contained statements of intention and of behavioral, normative, and control beliefs. Attitude was inferred from behavioral beliefs. Content validity evidence was established by experts in two countries and by pilot studies utilizing 96 university students to elicit accessible beliefs and intentions. Construct validity evidence was derived from data collected from 145 GPE and 47 adapted PE prospective teachers enrolled in three universities in the Czech Republic. Bivariate correlations, hierarchical regression analysis, and ANOVA examination of known group difference provided good validity evidence for the ATIPDPE. Alpha coefficients ranged from .71 to .94.

  15. The diagnostic performance of ultrasound for acute appendicitis in pregnant and young nonpregnant women: A case-control study.

    Science.gov (United States)

    Segev, Lior; Segev, Yakir; Rayman, Shlomi; Nissan, Aviram; Sadot, Eran

    2016-10-01

    Ultrasonography is frequently used to diagnose acute appendicitis in women of reproductive age, but its diagnostic value in pregnant patients remains unclear. This study sought to compare the diagnostic performance of ultrasound in pregnant and young nonpregnant women with suspected acute appendicitis. The database of a single tertiary medical center was reviewed for all women of reproductive age who underwent appendectomy either during pregnancy (2000-2014) or in the nonpregnant state (2004-2007) following ultrasound evaluation. The performance of ultrasound in terms of predicting the final pathologic diagnosis was compared between the pregnant and non pregnant groups using receiver operating characteristic curve analysis. Of 586 young women treated for appendicitis during the study periods (92 pregnant, 494 non-pregnant), 200 underwent preoperative ultrasound [67 pregnant, and 133 nonpregnant young women]. The pregnant and nonpregnant groups were comparable in age and presenting symptoms. There was no significant difference in the predictive performance of ultrasound between the two groups (AUC 0.76 and 0.73 respectively, p = 0.78) or within the pregnant group, by trimester [first (n = 23), AUC 0.73; second (n = 32), AUC 0.67; third (n = 12), AUC 0.86; p = 0.4]. Ultrasound had a positive predictive value of 0.94 in the pregnant group and 0.91 in the nonpregnant group; corresponding negative predictive values were 0.40 and 0.43. There appears to be no difference in the ability of ultrasound to predict the diagnosis of acute appendicitis between pregnant women and nonpregnant women of reproductive age. Therefore, similar preoperative imaging algorithms may be used in both patient populations. Copyright © 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  16. Polymethyl methacrylate-co-methacrylic acid coatings with controllable concentration of surface carboxyl groups: A novel approach in fabrication of polymeric platforms for potential bio-diagnostic devices

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini, Samira; Ibrahim, Fatimah [Center for Innovation in Medical Engineering, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603 (Malaysia); Djordjevic, Ivan, E-mail: ivan.djordjevic@um.edu.my [Center for Innovation in Medical Engineering, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603 (Malaysia); Koole, Leo H. [Center for Innovation in Medical Engineering, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603 (Malaysia); Department of Biomedical Engineering, Faculty of Health. Medicine and Life Science, Maastricht University, PO Box 616, NL 6200 MD Maastricht (Netherlands)

    2014-05-01

    Highlights: • Synthesis and processing of PMMA-co-MAA spin-coatings on silicon wafers. • Surface chemistry and morphology as a function of tailored co-polymer structure. • Polymer coatings with controlled number of surface carboxyl groups. - Abstract: The generally accepted strategy in development of bio-diagnostic devices is to immobilize proteins on polymeric surfaces as a part of detection process for diseases and viruses through antibody/antigen coupling. In that perspective, polymer surface properties such as concentration of functional groups must be closely controlled in order to preserve the protein activity. In order to improve the surface characteristics of transparent polymethacrylate plastics that are used for diagnostic devices, we have developed an effective fabrication procedure of polymethylmetacrylate-co-metacrylic acid (PMMA-co-MAA) coatings with controlled number of surface carboxyl groups. The polymers were processed effectively with the spin-coating technique and the detailed control over surface properties is here by demonstrated through the variation of a single synthesis reaction parameter. The chemical structure of synthesized and processed co-polymers has been investigated with nuclear magnetic resonance spectroscopy (NMR) and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-ToF-MS). The surface morphology of polymer coatings have been analyzed with atomic force microscopy (AFM) and scanning electron microscopy (SEM). We demonstrate that the surface morphology and the concentration of surface –COOH groups (determined with UV–vis surface titration) on the processed PMMA-co-MAA coatings can be precisely controlled by variation of initial molar ratio of reactants in the free-radical polymerization reaction. The wettability of developed polymer surfaces also varies with macromolecular structure.

  17. Tundish Cover Flux Thickness Measurement Method and Instrumentation Based on Computer Vision in Continuous Casting Tundish

    Directory of Open Access Journals (Sweden)

    Meng Lu

    2013-01-01

    Full Text Available Thickness of tundish cover flux (TCF plays an important role in continuous casting (CC steelmaking process. Traditional measurement method of TCF thickness is single/double wire methods, which have several problems such as personal security, easily affected by operators, and poor repeatability. To solve all these problems, in this paper, we specifically designed and built an instrumentation and presented a novel method to measure the TCF thickness. The instrumentation was composed of a measurement bar, a mechanical device, a high-definition industrial camera, a Siemens S7-200 programmable logic controller (PLC, and a computer. Our measurement method was based on the computer vision algorithms, including image denoising method, monocular range measurement method, scale invariant feature transform (SIFT, and image gray gradient detection method. Using the present instrumentation and method, images in the CC tundish can be collected by camera and transferred to computer to do imaging processing. Experiments showed that our instrumentation and method worked well at scene of steel plants, can accurately measure the thickness of TCF, and overcome the disadvantages of traditional measurement methods, or even replace the traditional ones.

  18. Smart portable electrophoresis instrument based on multipurpose microfluidic chips with electrochemical detection.

    Science.gov (United States)

    Fernández-la-Villa, Ana; Sánchez-Barragán, Dámaso; Pozo-Ayuso, Diego F; Castaño-Álvarez, Mario

    2012-09-01

    A second generation of a battery-powered portable electrophoresis instrument for the use of ME with electrochemical detection was developed. As the first-generation, the main unit of the instrument (150 mm × 165 mm × 95 mm) consists of four-outputs high-voltage power supply (HVPS) with maximum voltage of 3 KV and acquisition system (bipotentiostat) containing 2-channels for dual electrochemical detection. A new reusable microfluidic platform was designed in order to incorporate the microchips with the portable instrument. In this case, the platform is integrated to the main unit of the instrument so that it is not necessary to have any external cable for the interconnection of both parts, making the use of the complete system easier. The new platform contains all the electrical connections for the HVPS and bipotentiostat, as well as fluidic ports for driving the solutions. The microfluidic electrophoresis instrument is controlled by means of a user-friendly interface from a computer. The possibility of wireless connection (Bluetooth®) allows the use of the instrument without any external cable improving the portability. Therefore, the second generation brings a more compact and integrated electrophoresis instrument for "in situ" applications using microfluidic chips in an easy way. The performance of the electrophoresis system was initially evaluated using single- and dual-channel SU-8/Pyrex microchips with different models of integrated electrodes including microelectrodes and interdigitated arrays. The method was tested in different analytical applications such as separation of neurotransmitters, chlorophenols, purine derivatives, vitamins, polyphenolic acids, and flavones.

  19. Diagnostic Accuracy of Real-Time PCR Assays Targeting 16S rRNA and lipl32 Genes for Human Leptospirosis in Thailand: A Case-Control Study

    Science.gov (United States)

    Thaipadunpanit, Janjira; Chierakul, Wirongrong; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Amornchai, Premjit; Boonslip, Siriphan; Smythe, Lee D.; Limpaiboon, Roongrueng; Hoffmaster, Alex R.; Day, Nicholas P. J.; Peacock, Sharon J.

    2011-01-01

    Background Rapid PCR-based tests for the diagnosis of leptospirosis can provide information that contributes towards early patient management, but these have not been adopted in Thailand. Here, we compare the diagnostic sensitivity and specificity of two real-time PCR assays targeting rrs or lipL32 for the diagnosis of leptospirosis in northeast Thailand. Methods/Principal Findings A case-control study of 266 patients (133 cases of leptospirosis and 133 controls) was constructed to evaluate the diagnostic sensitivity and specificity (DSe & DSp) of both PCR assays. The median duration of illness prior to admission of cases was 4 days (IQR 2–5 days; range 1–12 days). DSe and DSp were determined using positive culture and/or microscopic agglutination test (MAT) as the gold standard. The DSe was higher for the rrs assay than the lipL32 assay (56%, (95% CI 47–64%) versus 43%, (95% CI 34–52%), p<0.001). No cases were positive for the lipL32 assay alone. There was borderline evidence to suggest that the DSp of the rrs assay was lower than the lipL32 assay (90% (95% CI 83–94%) versus 93%, (95%CI 88–97%), p = 0.06). Nine controls gave positive reactions for both assays and 5 controls gave a positive reaction for the rrs assay alone. The DSe of the rrs and lipL32 assays were high in the subgroup of 39 patients who were culture positive for Leptospira spp. (95% and 87%, respectively, p = 0.25). Conclusions/Significance Early detection of Leptospira using PCR is possible for more than half of patients presenting with leptospirosis and could contribute to individual patient care. PMID:21283633

  20. The Communication Supports Inventory-Children & Youth (CSI-CY), a new instrument based on the ICF-CY.

    Science.gov (United States)

    Rowland, Charity; Fried-Oken, Melanie; Bowser, Gayl; Granlund, Mats; Lollar, Donald; Phelps, Randall; Simeonsson, Rune J; Steiner, Sandra A M

    2016-09-01

    Two studies are presented that evaluated the Communication Supports Inventory-Children & Youth (CSI-CY), an instrument designed to facilitate the development of communication-related educational goals for students with complex communication needs (CCN). The CSI-CY incorporates a code set based on the ICF-CY. The studies were designed to determine the effect of using the CSI-CY on IEP goals for students with CCN and to evaluate consumer satisfaction. In Study 1, sixty-one educators and speech-language pathologists were randomly assigned to either (a) provide a student's current IEP (control group) or (b) complete the CSI-CY prior to preparing a student's next IEP and to submit the new IEP (experimental group). Study 2 was a field test to generate consumer satisfaction data. Study 1 showed that IEP goals submitted by participants in the experimental group referenced CSI-CY-related content significantly more frequently than did those submitted by control participants. Study 2 revealed high satisfaction with the instrument. The code set basis of the CSI-CY extends the common language of the ICF-CY to practical educational use for children with CCN across diagnostic groups. The CSI-CY is well regarded as an instrument to inform the content of communication goals related to CCN. Implications for Rehabilitation The CSI-CY will guide rehabilitation professionals to develop goals for children with complex communication impairments. The CSI-CY is a new instrument that is based on the ICF-CY for documentation of communication goals.

  1. Results of a multicentre randomised controlled trial of statistical process control charts and structured diagnostic tools to reduce ward-acquired meticillin-resistant Staphylococcus aureus: the CHART Project.

    Science.gov (United States)

    Curran, E; Harper, P; Loveday, H; Gilmour, H; Jones, S; Benneyan, J; Hood, J; Pratt, R

    2008-10-01

    Statistical process control (SPC) charts have previously been advocated for infection control quality improvement. To determine their effectiveness, a multicentre randomised controlled trial was undertaken to explore whether monthly SPC feedback from infection control nurses (ICNs) to healthcare workers of ward-acquired meticillin-resistant Staphylococcus aureus (WA-MRSA) colonisation or infection rates would produce any reductions in incidence. Seventy-five wards in 24 hospitals in the UK were randomised into three arms: (1) wards receiving SPC chart feedback; (2) wards receiving SPC chart feedback in conjunction with structured diagnostic tools; and (3) control wards receiving neither type of feedback. Twenty-five months of pre-intervention WA-MRSA data were compared with 24 months of post-intervention data. Statistically significant and sustained decreases in WA-MRSA rates were identified in all three arms (PTools wards, respectively). Participants identified SPC charts as an effective communication tool and valuable for disseminating WA-MRSA data.

  2. Assessment of African Swine Fever Diagnostic Techniques as a Response to the Epidemic Outbreaks in Eastern European Union Countries: How To Improve Surveillance and Control Programs.

    Science.gov (United States)

    Gallardo, C; Nieto, R; Soler, A; Pelayo, V; Fernández-Pinero, J; Markowska-Daniel, I; Pridotkas, G; Nurmoja, I; Granta, R; Simón, A; Pérez, C; Martín, E; Fernández-Pacheco, P; Arias, M

    2015-08-01

    This study represents a complete comparative analysis of the most widely used African swine fever (ASF) diagnostic techniques in the European Union (EU) using field and experimental samples from animals infected with genotype II ASF virus (ASFV) isolates circulating in Europe. To detect ASFV, three different PCRs were evaluated in parallel using 785 field and experimental samples. The results showed almost perfect agreement between the Universal ProbeLibrary (UPL-PCR) and the real-time (κ = 0.94 [95% confidence interval {CI}, 0.91 to 0.97]) and conventional (κ = 0.88 [95% CI, 0.83 to 0.92]) World Organisation for Animal Health (OIE)-prescribed PCRs. The UPL-PCR had greater diagnostic sensitivity for detecting survivors and allows earlier detection of the disease. Compared to the commercial antigen enzyme-linked immunosorbent assay (ELISA), good-to-moderate agreement (κ = 0.67 [95% CI, 0.58 to 0.76]) was obtained, with a sensitivity of 77.2% in the commercial test. For ASF antibody detection, five serological methods were tested, including three commercial ELISAs, the OIE-ELISA, and the confirmatory immunoperoxidase test (IPT). Greater sensitivity was obtained with the IPT than with the ELISAs, since the IPT was able to detect ASF antibodies at an earlier point in the serological response, when few antibodies are present. The analysis of the exudate tissues from dead wild boars showed that IPT might be a useful serological tool for determining whether or not animals had been exposed to virus infection, regardless of whether antibodies were present. In conclusion, the UPL-PCR in combination with the IPT was the most trustworthy method for detecting ASF during the epidemic outbreaks affecting EU countries in 2014. The use of the most appropriate diagnostic tools is critical when implementing effective control programs.

  3. Development of an anthropomorphic thorax phantom for image quality control measurements in diagnostic radiology; Construcao de um objeto simulador antropomorfico de torax para medidas de controle da qualidade da imagem em radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Cerqueira, Rafaela A.D.; Maia, Ana F., E-mail: rafaelatoff@yahoo.com.b [Universidade Federal de Sergipe (DF/UFS), Sao Cristovao, SE (Brazil). Dept. de Fisica; Conceicao, Bruno M.; Teixeira, Carlos H.C.; Mota, Cleber D.; Rodrigues, Tania M.A. [Universidade Federal de Sergipe (DM/UFS), Sao Cristovao, SE (Brazil). Dept. de Morfologia

    2011-07-01

    The use of the ionizing radiation brought by countless benefits to man. But they are associated to the current damages of radiation interaction with the body. Quality control programs of the diagnostic radiology equipment are based in the prevalence of the benefits above the damages. This program determines that tests should be done to guarantee the quality of the medical images, reducing the patients and workers absorbed doses and the cost. However, those tests cannot be made in people and it is on this moment that phantoms are used. Diagnostic radiology phantoms can be of several types, going from simple boxes to the exact representation in the human body, called anthropomorphic phantom. The aim of this study was to develop an anthropomorphic thorax phantom to be used in tests for image quality control measurements in diagnostic radiology and also for professionals' training for analysis of radiologic images. This simulator was made with natural human skeleton, heart and lungs, besides the thorax soft tissue were simulated using epoxy-resin tissue and a pair of lungs was made of foamed-polyurethane. (author)

  4. Development of an anthropomorphic thorax phantom for image quality control measurements in diagnostic radiology; Construcao de um objeto simulador antropomorfico de torax para medidas de controle da qualidade de imagem em radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Cerqueira, R.A.D.; Maia, A.F., E-mail: rafaelatoff@yahoo.com.b [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Dept. de Fisica; Conceicao, B.M.; Teixeira, C.H.C.; Mota, C.D.; Rodrigues, T.M.A. [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Dept. de Morfologia

    2010-07-01

    The use of the ionizing radiation brought by countless benefits to man. But they are associated to the current damages of radiation interaction with the body. Quality control programs of the diagnostic radiology equipment are based in the prevalence of the benefits above the damages. This program determines that tests should be done to guarantee the quality of the medical images, reducing the patients and workers absorbed doses and the cost. However, those tests cannot be made in people and it is on this moment that phantoms are used. Diagnostic radiology phantoms can be of several types, going from simple boxes to the exact representation in the human body, called anthropomorphic phantom. The aim of this study was to develop an anthropomorphic thorax phantom to be used in tests for image quality control measurements in diagnostic radiology and also for professionals' training for analysis of radiologic images. This simulator was made with natural human skeleton, heart and lungs, besides the thorax soft tissue were simulated using epoxy-resin tissue and a pair of lungs was made of foamed-polyurethane. (author)

  5. THE DIAGNOSTIC SPECIFICATIONS IMPROVEMENT FOR ROLLING STOCK’S TRACTION WITH USING OF DAMPING CONTROL OF VIBRATIONAL ENERGY

    OpenAIRE

    Horobets, V. L.; Snitko, N. P.; A. D. Lashko

    2010-01-01

    In the paper an approximate classification of methods of damping oscillations for complex mechanical systems is offered as well as the approach of an adaptive control by dissipation of the vibration energy of the railway rolling stock devices is presented.

  6. The diagnostic value of controlled oral word association test-FAS and category fluency in single-domain amnestic mild cognitive impairment.

    Science.gov (United States)

    Malek-Ahmadi, Michael; Small, Brent J; Raj, Ashok

    2011-01-01

    Recent studies have shown that decreases in both letter fluency and category fluency may be present in addition to memory impairment in single-domain amnestic mild cognitive impairment (aMCI). However, the clinical utility of these fluency measures is unclear. The aim of this study was to determine what, if any, diagnostic value letter and category fluency provide in differentiating single-domain aMCI from normal cognition. Data from 66 individuals [33 cognitively normal (CN) and 33 aMCI] between the ages of 66 and 87 years participating in the Florida Alzheimer's Disease Research Center were compared on the Controlled Oral Word Association Test (COWAT)-FAS and Category Fluency test, both in terms of raw and scaled scores. Participants were matched on age, education and sex. Two-tailed independent sample t-tests found statistically significant differences between the CN and aMCI groups for both raw and scaled scores of COWAT-FAS and Category Fluency (p Fluency did not significantly improve diagnostic accuracy when combined with the Hopkins Verbal Learning Test-Revised delayed recall. Although decreased COWAT-FAS and Category Fluency performance may be present in single-domain aMCI, these tests do not improve the ability of the Hopkins Verbal Learning Test-Revised delayed recall to differentiate aMCI from CN individuals. Copyright © 2011 S. Karger AG, Basel.

  7. Double-blinded, randomized controlled trial comparing real versus placebo acupuncture to improve tolerance of diagnostic esophagogastroduodenoscopy without sedation: a study protocol

    Directory of Open Access Journals (Sweden)

    Plaschke K

    2011-02-01

    Full Text Available Abstract Background Sedation prior to performance of diagnostic esophagogastroduodenoscopy (EGDE is widespread and increases patient comfort. But 98% of all serious adverse events during EGDEs are ascribed to sedation. The S3 guideline for sedation procedures in gastrointestinal endoscopy published in 2008 in Germany increases patient safety by standardization. These new regulations increase costs because of the need for more personnel and a prolonged discharge procedure after examinations with sedation. Many patients have difficulties to meet the discharge criteria regulated by the S3 guideline, e.g. the call for a second person to escort them home, to resign from driving and working for the rest of the day, resulting in a refusal of sedation. Therefore, we would like to examine if an acupuncture during elective, diagnostic EGDEs could increase the comfort of patients refusing systemic sedation. Methods/Design A single-center, double blinded, placebo controlled superiority trial to compare the success rates of elective, diagnostic EGDEs with real and placebo acupuncture. All patients aged 18 years or older scheduled for elective, diagnostic EGDE who refuse a systemic sedation are eligible. 354 patients will be randomized. The primary endpoint is the rate of successful EGDEs with the randomized technique. Intervention: Real or placebo acupuncture before and during EGDE. Duration of study: Approximately 24 months. Discussion Organisation/Responsibility The ACUPEND - Trial will be conducted in accordance with the protocol and in compliance with the moral, ethical, and scientific principles governing clinical research as set out in the Declaration of Helsinki (1989 and Good Clinical Practice (GCP. The Interdisciplinary Endoscopy Center (IEZ of the University Hospital Heidelberg is responsible for design and conduct of the trial, including randomization and documentation of patients' data. Data management and statistical analysis will be performed

  8. ITER diagnostics ex-vessel engineering services

    Energy Technology Data Exchange (ETDEWEB)

    Arumugam, A.P., E-mail: arun.prakash@iter.org; Walker, C.I.; Andrew, P.; Barnsley, R.; Beltran, D.; Bertalot, L.; Dammann, A.; Direz, M.F.; Drevon, J.M.; Encheva, A.; Giacomin, T.; Hourtoule, J.; Kuehn, I.; Lanza, R.; Levesy, B.; Maquet, P.; Patel, K.M.; Patisson, L.; Pitcher, C.S.; Portales, M.; and others

    2013-10-15

    Highlights: • This paper describes about the ITER diagnostics ex-vessel engineering services. • It describes various diagnostics systems, its location and its environment. • Diagnostics interfaces with other services such as the buildings, HVAC, electrical services, cooling water, vacuum, liquid and gas distribution. • All the interfaces with these services are identified and defined. • Buildings services for diagnostics, such as penetrations, local shielding, embedment and temperature control are discussed. -- Abstract: Extensive diagnostics systems will be installed on the ITER machine to provide the measurements necessary to control, evaluate and optimize plasma performance in ITER and to further the understanding of plasma physics. These include measurements of temperature, density, impurity concentration, and particle and energy confinement times. ITER diagnostic systems extend from the center of the Tokamak to the various diagnostic areas, where they are controlled and acquired data is processed. This mainly includes the areas such as ports, port cells, gallery, diagnostics enclosures and cubicle areas. The diagnostics port plugs encloses the front end of the diagnostic systems and the diagnostics building houses the diagnostics equipment, instrumentation and control cubicles. There are several systems providing services to diagnostics. These mainly include ITER buildings, electrical power services, cooling water services, Heating Ventilation and Air Conditioning (HVAC), vacuum services, liquid and gas distribution services, cable engineering, de-tritiation systems, control cubicles, etc. Requirements of these service systems have to be defined, even though many of the diagnostics are at an early stage of development. It is a real challenge to define and to design diagnostics systems considering the constraints imposed by these service systems. This paper summarizes the provision of these services to the individual diagnostics and diagnostics areas

  9. Beamlet laser diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Burkhart, S.C.; Behrendt, W.C.; Smith, I.

    1996-06-01

    Beamlet is instrumented extensively to monitor the performance of the overall laser system and many of its subsystems. Beam diagnostics, installed in key locations, are used to fully characterize the beam during its propagation through the multipass cavity and the laser`s output section. This article describes the diagnostics stations located on Beamlet and discusses the design, calibration, and performance of the Beamlet calorimeters. The authors used Nova`s diagnostics packages to develop the Beamlet design to determine beam energy, spatial profile, temporal profile, and other beam parameters. Technologic improvements within the last several years in controls, charge-coupled device (CCD) cameras, and fast oscilloscopes have allowed the authors to obtain more accurate measurements on the Beamlet laser system. They briefly cover some of these techniques, including a description of their LabVIEW based data acquisition system.

  10. Diagnostic Method, Prevention and Control Measures of Animal Brucellosis%畜间布鲁菌病的诊断方法与防控措施

    Institute of Scientific and Technical Information of China (English)

    张斌; 王小军; 魏晔雄; 白艳艳

    2012-01-01

    Brucellosis is a kind of zoonosis that caused by Brucella bacteria, it brings serious damage to animal husbandry and human health. This paper introduces diagnostic method, prevention and control measures of animal Brucellosis etiology and serology, in hopes of providing reference for correlation research.%布鲁菌病(brucellosis)是由布鲁茵(Brucella)引起的一种人畜共患传染病,给畜牧业发展和人类健康带来严重危害。主要对布鲁菌病的病原学和血清学诊断方法以及防控措施作一介绍。以期为布鲁茵病的相关研究提供参考。

  11. Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015.

    Science.gov (United States)

    Flint, Mike; Goodman, Christin H; Bearden, Scott; Blau, Dianna M; Amman, Brian R; Basile, Alison J; Belser, Jessica A; Bergeron, Éric; Bowen, Michael D; Brault, Aaron C; Campbell, Shelley; Chakrabarti, Ayan K; Dodd, Kimberly A; Erickson, Bobbie R; Freeman, Molly M; Gibbons, Aridth; Guerrero, Lisa W; Klena, John D; Lash, R Ryan; Lo, Michael K; McMullan, Laura K; Momoh, Gbetuwa; Massally, James L; Goba, Augustine; Paddock, Christopher D; Priestley, Rachael A; Pyle, Meredith; Rayfield, Mark; Russell, Brandy J; Salzer, Johanna S; Sanchez, Angela J; Schuh, Amy J; Sealy, Tara K; Steinau, Martin; Stoddard, Robyn A; Taboy, Céline; Turnsek, Maryann; Wang, David; Zemtsova, Galina E; Zivcec, Marko; Spiropoulou, Christina F; Ströher, Ute; Towner, Jonathan S; Nichol, Stuart T; Bird, Brian H

    2015-10-01

    In August 2014, the Viral Special Pathogens Branch of the US Centers for Disease Control and Prevention established a field laboratory in Sierra Leone in response to the ongoing Ebola virus outbreak. Through March 2015, this laboratory tested >12 000 specimens from throughout Sierra Leone. We describe the organization and procedures of the laboratory located in Bo, Sierra Leone.

  12. Control loop performance evaluation and diagnostic in the oil refining process; Avaliacao de desempenho e diagnostico das malhas de controle no processo de refino de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Regina Lucia de A.; Pavanelli, Paula E. [Chemtech, Rio de Janeiro, RJ (Brazil); Miranda, Filipe Costa Pinto dos R. [PETROBRAS S.A., Maua, SP (Brazil). Refinaria de Capuava (RECAP)

    2008-07-01

    Management Assets has been a theme treated with growing priority and importance by Processes Industry. Control loops are important assets to guarantee the security and operational stability of processes when they present a good performance. Usually there are a large number of control loops in processes units and their initial investment and maintenance costs are expensive. Human evaluation of control loops, in a non-systematic way, does not identify all the problems that can degrade regulatory control performance, and this the main reason to use systematic monitoring and evaluation techniques and software tools necessary to keep loops efficient. This work describes the continuous activity of monitoring and evaluation of the control systems of a petroleum refinery. Depending on some performance indexes, the loops are prioritized and some actions are taken (valve maintenance or tuning adjustment) to improve control loop performance and to avoid the reduction of product quality, raw material and utilities waste and even unit shutdown. (author)

  13. Thyroid diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Scriba, P.C.; Boerner, W.; Emrich, S.; Gutekunst, R.; Herrmann, J.; Horn, K.; Klett, M.; Krueskemper, H.L.; Pfannenstiel, P.; Pickardt, C.R.

    1985-03-01

    None of the in-vitro and in-vivo methods listed permits on unambiguous diagnosis when applied alone, owing to the fact that similar or even identical findings are obtained for various individual parameters in different thyroid diseases. Further, especially the in-vitro tests are also subject to extrathyroidal effects which may mask the typical findings. The limited and varying specificity and sensitivity of the tests applied, as well as the falsification of results caused by the patients' idiosyncracies and the methodology, make it necessary to interpret and evaluate the in-vivo and in-vitro findings only if the clinical situation (anamnesis and physical examination) is known. For maximum diagnostic quality of the tests, the initial probability of the assumed type of thyroid disease must be increased (formulation of the clinical problem). The concepts of exclusion diagnosis and identification must be distinguished as well as the diagnosis of functional disturbances on the one hand and of thyroid diseases on the other. Both of this requires a qualified, specific and detailed anamnesis and examination procedure, and the clinical examination remains the obligatory basis of clinical diagnostics. In case of inexplicable discrepancies between the clinical manifestations and the findings obtained with specific methods, or between the findings obtained with a specific method, the patient should be referred to an expert institution, or the expert institution should be consulted.

  14. A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study

    Directory of Open Access Journals (Sweden)

    Bünger Stefanie

    2012-09-01

    Full Text Available Abstract Background More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions. Methods A nine target multiplex serum protein biochip was generated and evaluated using a training- and validation-set of 317 highly standardized, liquid nitrogen preserved serum samples comprising controls, adenomas, and colon cancers. Results Serum levels of CEA, IL-8, VEGF, S100A11, MCSF, C3adesArg, CD26, and CRP showed significant differences between cases and controls. The largest areas under the receiver operating characteristics curve were observed for CEA, IL-8, and CRP. At threshold levels yielding 90% specificity, sensitivities for CEA, IL-8 and CRP were 26%, 22%, and 17%, respectively. The most promising marker combinations were CEA + IL-8 reaching 37% sensitivity at 83% specificity and CEA + CRP with 35% sensitivity at 81% specificity. In an independent validation set CEA + IL-8 reached 47% sensitivity at 86% specificity while CEA + CRP obtained 39% sensitivity at 86% specificity. Early carcinomas were detected with 33% sensitivity for CEA + IL-8 and 28% for CEA + CRP. Conclusions Apart from CEA, IL-8, and CRP, the screening value of additional blood markers and the potential advantage of combining serum biochip testing with fecal occult blood testing needs to be studied. Multiplex biochip array technology utilizing serum samples offers an innovative approach to colorectal cancer screening.

  15. Rotorcraft Diagnostics

    Science.gov (United States)

    Haste, Deepak; Azam, Mohammad; Ghoshal, Sudipto; Monte, James

    2012-01-01

    Health management (HM) in any engineering systems requires adequate understanding about the system s functioning; a sufficient amount of monitored data; the capability to extract, analyze, and collate information; and the capability to combine understanding and information for HM-related estimation and decision-making. Rotorcraft systems are, in general, highly complex. Obtaining adequate understanding about functioning of such systems is quite difficult, because of the proprietary (restricted access) nature of their designs and dynamic models. Development of an EIM (exact inverse map) solution for rotorcraft requires a process that can overcome the abovementioned difficulties and maximally utilize monitored information for HM facilitation via employing advanced analytic techniques. The goal was to develop a versatile HM solution for rotorcraft for facilitation of the Condition Based Maintenance Plus (CBM+) capabilities. The effort was geared towards developing analytic and reasoning techniques, and proving the ability to embed the required capabilities on a rotorcraft platform, paving the way for implementing the solution on an aircraft-level system for consolidation and reporting. The solution for rotorcraft can he used offboard or embedded directly onto a rotorcraft system. The envisioned solution utilizes available monitored and archived data for real-time fault detection and identification, failure precursor identification, and offline fault detection and diagnostics, health condition forecasting, optimal guided troubleshooting, and maintenance decision support. A variant of the onboard version is a self-contained hardware and software (HW+SW) package that can be embedded on rotorcraft systems. The HM solution comprises components that gather/ingest data and information, perform information/feature extraction, analyze information in conjunction with the dependency/diagnostic model of the target system, facilitate optimal guided troubleshooting, and offer

  16. Spatially resolved measurements and diagnostics of digitally controlled rotating field pulsed plasma operated in helium at 20 kHz

    Science.gov (United States)

    Giersz, Jacek; Jankowski, Krzysztof; Reszke, Edward

    2017-04-01

    Using optical emission spectrometry, fundamental properties are investigated of a stable, planar atmospheric pressure micro discharge, several dozen microliters in volume, driven by a digitally controlled 20 kHz rotating microsecond pulsed power. The discharge is generated by rectangular wave pulses using helium as the working gas. At a low cost, the digitally controlled plasma source produces a highly symmetrical, non-stationary helium discharge maintained in open air within 5 electrodes positioned in the plane toward the center. It has been shown that the geometrical shapes of the momentary discharges, which occur between the electrodes, are not arc-like shaped, but rather have a diffusive character and the resulting plasma can become doughnut-like in shape. Rotational and vibrational temperatures from OH and N2 bands, excitation temperatures from He lines and ionization temperatures from Ca lines, as well as electron number densities from Hβ Stark broadening have been estimated along the plasma diameter using axial viewing. The results demonstrated that Texc (He) reaches stable value of 3800 K for selected plasma generation conditions (one anode and two cathodes commutation mode, cathode pulse width 8 microseconds, supplied power 200 W, helium gas flow 1 L·min- 1), while the Trot (OH) is considerably lower (1700 K). The electron number density has been evaluated to be (1.7-3.3) × 1014 cm- 3 and both Tion (Ca) and Tvib (N2) varied, throughout in the 4500-5100 K and 4000-4800 K ranges respectively, reaching its peak value near 2 mm off the plasma axis. Spatial measurements revealed symmetrical distribution of the plasma parameters, while the measurements of calcium and nitrogen ionic emission confirmed symmetrical doughnut shape of the discharge. Moreover, the processes running inside the discharge and their interaction with the surrounding atmosphere have been described in accordance to the recorded spectra. Spectroscopic observation has shown the existence of

  17. Optical methods for diagnostics and feedback control in laser-induced regeneration of spine disc and joint cartilages

    Science.gov (United States)

    Sobol, Emil; Sviridov, Alexander; Omeltchenko, Alexander; Baum, Olga; Baskov, Andrey; Borchshenko, Igor; Golubev, Vladimir; Baskov, Vladimir

    2011-03-01

    In 1999 we have introduced a new approach for treatment of spine diseases based on the mechanical effect of nondestructive laser radiation on the nucleus pulposus of the intervertebral disc. Laser reconstruction of spine discs (LRD) involves puncture of the disc and non-destructive laser irradiation of the nucleus pulposus to activate reparative processes in the disc tissues. In vivo animal study has shown that LRD allows activate the growth of hyaline type cartilage in laser affected zone. The paper considers physical processes and mechanisms of laser regeneration, presents results of investigations aimed to optimize laser settings and to develop feedback control system for laser reparation in cartilages of spine and joints. The results of laser reconstruction of intervertebral discs for 510 patients have shown substantial relief of back pain for 90% of patients. Laser technology has been experimentally tested for reparation of traumatic and degenerative diseases in joint cartilage of 20 minipigs. It is shown that laser regeneration of cartilage allows feeling large (more than 5 mm) defects which usually never repair on one's own. Optical techniques have been used to promote safety and efficacy of the laser procedures.

  18. Investigation of irradiation effects on highly integrated leading-edge electronic components of diagnostics and control systems for LHD deuterium operation

    Science.gov (United States)

    Ogawa, K.; Nishitani, T.; Isobe, M.; Murata, I.; Hatano, Y.; Matsuyama, S.; Nakanishi, H.; Mukai, K.; Sato, M.; Yokota, M.; Kobuchi, T.; Nishimura, T.; Osakabe, M.

    2017-08-01

    High-temperature and high-density plasmas are achieved by means of real-time control, fast diagnostic, and high-power heating systems. Those systems are precisely controlled via highly integrated electronic components, but can be seriously affected by radiation damage. Therefore, the effects of irradiation on currently used electronic components should be investigated for the control and measurement of Large Helical Device (LHD) deuterium plasmas. For the precise estimation of the radiation field in the LHD torus hall, the MCNP6 code is used with the cross-section library ENDF B-VI. The geometry is modeled on the computer-aided design. The dose on silicon, which is a major ingredient of electronic components, over nine years of LHD deuterium operation shows that the gamma-ray contribution is dominant. Neutron irradiation tests were performed in the OKTAVIAN at Osaka University and the Fast Neutron Laboratory at Tohoku University. Gamma-ray irradiation tests were performed at the Nagoya University Cobalt-60 irradiation facility. We found that there are ethernet connection failures of programmable logic controller (PLC) modules due to neutron irradiation with a neutron flux of 3  ×  106 cm-2 s-1. This neutron flux is equivalent to that expected at basement level in the LHD torus hall without a neutron shield. Most modules of the PLC are broken around a gamma-ray dose of 100 Gy. This is comparable with the dose in the LHD torus hall over nine years. If we consider the dose only, these components may survive more than nine years. For the safety of the LHD operation, the electronic components in the torus hall have been rearranged.

  19. Touchless control module for diagnostic images at the surgery room using the Leap Motion system and 3D Slicer Software

    Directory of Open Access Journals (Sweden)

    Andrés Felipe Botero-Ospina

    2017-01-01

    Full Text Available Durante los procedimientos quirúrgicos es importante que el personal (cirujanos, residentes o asistentes interactúe con el paciente, evitando cualquier contacto físico con equipo y materiales que pudieron no ser esterilizados apropiadamente. Esto se hace con el fin de evitar al paciente infecciones y complicaciones posteriores a la cirugía. Con el aumento de la disponibilidad de imágenes diagnósticas esta herramienta se ha hecho cada vez más indispensable en los quirófanos, pero no siempre es posible mantener el control de asepsia de los equipos informáticos en los cuales se ejecutan los programas de visualización, factor que dificulta el acceso al personal asistencial a la información contenida en las imágenes. En este trabajo se presenta el desarrollo de un sistema que permite manipular un programa de visualización de imágenes diagnósticas mediante gestos evitando que el cirujano tenga contacto directo con la computadora. El sistema, que requiere una computadora con el software 3D-Slicer y el dispositivo Leap Motion, permite mediante gestos realizados con las manos acceder a operaciones básicas como el movimiento entre cortes de un volumen, cambio del tamaño de la imagen y cambio del plano anatómico de visualización, operaciones que para el cirujano son esenciales para la ubicación espacial y la toma de decisiones.

  20. 基于Softmax回归的电力仪表分类%Classification of Electric Instruments Based on Softmax Regression

    Institute of Scientific and Technical Information of China (English)

    王晟

    2014-01-01

    The intelligence of substations in Smart Grid contains substations detecting and recording the states and readouts of their electric instru-ments. Current methods usually analyze the images of electric instruments to get their states and readouts. Before analysis, an image should be correctly classified into one specific kind of electric instrument. Proposes electric instruments based on Softmax regression to solve this problem. This method contains three stages: image pre-processing, dimensional reduction and training Softmax regression mod-el. In the experiments which use real electric instrument images to train and test, this method gives a very good classification accuracy that proves its effectiveness.%智能电网中变电站的智能化,要求变电站能够智能检测并记录反映其运行情况的开关状态、电表数据。现有的方法多是通过获得电表的图片,针对图片分析其状态、数据。然而在分析具体电表数据之前,需要对图片进行分类,判断当前图片对应哪一种电表。基于Softmax回归的电力仪表分类正是为了解决这个问题而提出的分类方法,分为图片预处理、降维、Softmax回归模型的训练三个步骤。在真实变电站电力仪表图片组成的实验数据测试下,能够保持非常高的识别率,从而有效地解决这一问题。

  1. The Development Of Career Competence Instrument Based On Computer Assisted Testing For Students Of Junior High Schools In Jakarta, Indonesia

    Directory of Open Access Journals (Sweden)

    Dr. Gantina Komalasari, M.Psi

    2015-12-01

    Full Text Available This research is motivated by results of theoretical studies and empirical facts about the importance of student’s career competence achievement, as well as the study of government policies on the mandate for the assessment in the specialization program/career counseling of Junior High School students. The research was aimed at developing student’s career competence standardized instrument based on Computer Assisted Testing (CAT which is effective as a support system of specialization program/career counseling in junior high schools. The study employed the standardized instrument development procedure (Anwar, 2010. The study population was all Grade IX students of Junior High School of Jakarta in the academic year of 2015/2016. The research sample was gained by using multistage cluster random sampling technique. Members of the research sample were 466 junior high school students representing the five regions of Jakarta. The data collection was performed by using Junior High School Student’s Career Competence Scale. The data were then analyzed by using validity and reliability tests. Operational data analysis was performed by using IBM SPSS version 20.0 for Windows. The results show that: first, all statements of Junior High School Student’s Career Competence Scale are valid because the Sig. (2-tailed < α (0.05; second, the reliability of Junior High School Student’s Career Competence Scale is in the high category because the reliability index reached r = 0.880. The final version of Junior High School Student’s Career Competence Scale consists of 43 items.

  2. Hardware and software design for a National Instrument-based magnetic induction tomography system for prospective biomedical applications.

    Science.gov (United States)

    Wei, Hsin-Yu; Soleimani, Manuchehr

    2012-05-01

    Magnetic induction tomography (MIT) is a new and emerging type of tomography technique that is able to map the passive electromagnetic properties (in particular conductivity) of an object. Excitation coils are used to induce eddy currents in the medium, and the magnetic field produced by the induced eddy current is then sensed by the receiver coils. Because of its non-invasive and contactless feature, it becomes an attractive technique for many applications (especially in biomedical area) compared to traditional contact electrode-based electrical impedance tomography. Due to the low contrast in conductivity between biological tissues, an accurate and stable hardware system is necessary. Most MIT systems in the literature employ external signal generators, power amplifiers and highly stable down-conversion electronics to obtain a satisfactory phase measurement. However, this would increase design complexity substantially. In this paper, a National Instrument-based MIT system is developed at the University of Bath, aiming for biomedical applications. The system utilizes National Instrument products to accomplish all signal driving, switching and data acquisition tasks, which ease the system design whilst providing satisfactory performance. This paper presents a full-scaled medical MIT system, from the sensor and system hardware design, eddy current model verification to the image reconstruction software: the performance of this MIT instrumentation system is characterized in detail, including the system accuracy and system stability. The methods of solving eddy current problem are presented. The reconstructed images of detecting the presence of saline solutions are also included in this paper, which show the capability of national instrument products to be developed into a full-scaled biomedical MIT system, by demonstrating the practical experimental results.

  3. Novel adiponectin-resistin (AR and insulin resistance (IRAR indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study

    Directory of Open Access Journals (Sweden)

    Muniandy Sekaran

    2011-01-01

    Full Text Available Abstract Background Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM, metabolic syndrome (MS and cardiovascular disease. The aim of this study was to propose a novel adiponectin-resistin (AR index by taking into account both adiponectin and resistin levels to povide a better indicator of the metabolic homeostasis and metabolic disorders. In addition, a novel insulin resistance (IRAR index was proposed by integration of the AR index into an existing insulin resistance index to provide an improved diagnostic biomarker of insulin sensitivity. Methods In this case control study, anthropometric clinical and metabolic parameters including fasting serum total adiponectin and resistin levels were determined in 809 Malaysian men (208 controls, 174 MS without T2DM, 171 T2DM without MS, 256 T2DM with MS whose ages ranged between 40-70 years old. Significant differences in continuous variables among subject groups were confirmed by ANCOVA or MANCOVA test using 1,000 stratified bootstrap samples with bias corrected and accelerated (BCa 95% CI. Spearman's rho rank correlation test was used to test the correlation between two variables. Results The AR index was formulated as 1+log10(R0-log10(A0. The AR index was more strongly associated with increased risk of T2DM and MS than hypoadiponectinemia and hyperresistinemia alone. The AR index was more strongly correlated with the insulin resistance indexes and key metabolic endpoints of T2DM and MS than adiponectin and resistin levels alone. The AR index was also correlated with a higher number of MS components than adiponectin and resistin levels alone. The IRAR index was formulated as log10(I0G0+log10(I0G0log10(R0/A0. The normal reference range of the IRAR index for insulin sensitive individuals was

  4. Diagnostic thoracoscopy

    Directory of Open Access Journals (Sweden)

    Plavec Goran

    2002-01-01

    Full Text Available Diagnostic thoracoscopy in patients with pleural effusion of unclear origin mostly provides the correct diagnosis. Results from published reports of previous researches are not uniform. In 47 male and 20 female patients with pleural effusion of unknown etiology, after receiving negative results obtained from cytological finding of pleural effusion and percutaneous needle biopsy, thoracoscopy with biopsy of one or both pleurae was performed. Procedure was done in local anesthesia using Stortz rigid thoracoscope. In 37 patients with malignant disease (primary or metastatic diagnosis was confirmed histopathologically in 31 patient (81.12%. In 27 patients with inflammatory pleural disease diagnosis was confirmed histopathologically in 22 patients (81.4%. Among 11 patients with specific pleural effusions, tuberculosis was confirmed in 10 (90.91%. Normal finding in cases of spontaneous pneumothorax and pulmonary embolism was taken as a positive result. Total number of positive findings was 55 (82.10%. In one patient, the third spontaneous pneumothorax was the indication for thoracoscopy, and after numerous bullae were seen during the procedure, talcum powder pleurodesis was done. In four patients low intensity subcutaneous emphysema occurred one day after thoracoscopy. It can be concluded that thoracoscopy in local anesthesia out of the operating room is good and practical method for solving the unclear pleural effusions, with neglectable rate of complications.

  5. Diagnostic accuracy of point-of-care testing for acute coronary syndromes, heart failure and thromboembolic events in primary care: a cluster-randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Diemand Albert

    2011-03-01

    Full Text Available Abstract Background Evidence of the clinical benefit of 3-in-1 point-of-care testing (POCT for cardiac troponin T (cTnT, N-terminal pro-brain natriuretic peptide (NT-proBNP and D-dimer in cardiovascular risk stratification at primary care level for diagnosing acute coronary syndromes (ACS, heart failure (HF and thromboembolic events (TE is very limited. The aim of this study is to analyse the diagnostic accuracy of POCT in primary care. Methods Prospective multicentre controlled trial cluster-randomised to POCT-assisted diagnosis and conventional diagnosis (controls. Men and women presenting in 68 primary care practices in Zurich County (Switzerland with chest pain or symptoms of dyspnoea or TE were consecutively included after baseline consultation and working diagnosis. A follow-up visit including confirmed diagnosis was performed to determine the accuracy of the working diagnosis, and comparison of working diagnosis accuracy between the two groups. Results The 218 POCT patients and 151 conventional diagnosis controls were mostly similar in characteristics, symptoms and pre-existing diagnoses, but differed in working diagnosis frequencies. However, the follow-up visit showed no statistical intergroup difference in confirmed diagnosis frequencies. Working diagnoses overall were significantly more correct in the POCT group (75.7% vs 59.6%, p = 0.002, as were the working diagnoses of ACS/HF/TE (69.8% vs 45.2%, p = 0.002. All three biomarker tests showed good sensitivity and specificity. Conclusion POCT confers substantial benefit in primary care by correctly diagnosing significantly more patients. Trial registration DRKS: DRKS00000709

  6. Requirements for ITER diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Young, K.M.

    1991-01-01

    The development and design of plasma diagnostics for the International Thermonuclear Experimental Reactor (ITER) present a formidable challenge for experimental plasma physicists. The large plasma size, the high central density and temperature and the very high thermal wall loadings provide new challenges for present measurement techniques and lead to a search for new methods. But the physics and control requirements for the long burn phase of the discharge, combined with very limited access to the plasma, constrained by the requirement for radiation shielding of the coils and sharing of access ports with heating and current drive power, remote manipulation, fueling and turn blanket modules, make for very difficult design choices. An initial attempt at these choices has been made by an international team of diagnostic physicists, gathering together in a series of three workshops during the ITER Conceptual Design Activity. This paper is based on that report and provides a summary of its most important points. To provide a background against which to place the diagnostic requirements and design concepts, the ITER device, its most important plasma properties and the proposed experimental program will be described. The specifications for the measurement of the plasma parameters and the proposed diagnostics for these measurements will then be addressed, followed by some examples of the design concepts that have been proposed. As a result of these design studies, it was clear that there were many uncertainties associated with these concepts, particularly because of the nuclear radiation environment, so that a Research and Development Program for diagnostic hardware was established. It will also be briefly summarized.

  7. Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study

    Directory of Open Access Journals (Sweden)

    Zhi-Peng Xu

    2016-03-01

    Interpretation: Aging, activation of peripheral circulating GSK-3β, expression of ApoE ε4 and increase of olfactory score are diagnostic for the mild cognitive impairment in T2DM patients, and combination of these biomarkers can improve the diagnostic accuracy.

  8. Control and diagnosis oriented modelling of the compression ignition engine; Modelisation du moteur a allumage par compression dans la perspective du controle et du diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Grondin, O.

    2004-12-15

    This thesis has described an investigation into the modelling of compression ignition engine for control and diagnosis purpose. The Diesel engine is the most efficient and clean internal combustion engine due to modem electromechanical actuators. However, pollutant emission regulations are much more stricter, thus, these complex systems need sophisticated and efficient control algorithms to reach very low emission levels. For this task, engine models are required at each step of the control system development: control laws synthesis, simulation and validation. The system under study is a six cylinder direct injection Diesel engine fitted with a turbocharger. The model of this system is based on physical laws for some parts of the engine such as cylinders, manifolds, turbocharger and crank-slider system. In order to reduce computing time we choose to model heat transfer and heat release during combustion using simple empirical correlations. Resulting model has been implemented in the Matlab-Simulink environment and it can predict variables of interest for control purpose with one degree crank angle resolution. The model has been tested numerically and compared with an industrial engine simulation code with good results. Moreover, model output variables are in good agreement with experimental data recorded on a heavy-duty research engine. The engine model has been embedded on a board providing enough computing performances to perform real-time simulations, this will be helpful for 'hardware-in-the-loop' simulations. Another part of this study is dedicated to the combustion process modelling using a non linear phenomenological model: the NARMAX model. The goal is to predict the in-cylinder pressure evolution using other measurements available on the engine. The NARMAX model parameters have been identified using input-output data carried out from the experimental engine. Such model is well suited for real-time applications compare to numerically cost

  9. Industrial applications of laser diagnostics

    CERN Document Server

    Deguchi, Yoshihiro

    2011-01-01

    Tighter regulations of harmful substances such as NOx, CO, heavy metals, particles, emissions from commercial plants and automobiles reflect a growing demand for lowering the anthropogenic burdens on the environment. It is equally important to monitor controlling factors to improve the operation of industrial machinery and plants. Among the many methods for doing this, laser diagnostics stands out. Taking a practical approach, Industrial Applications of Laser Diagnostics discusses how to apply laser diagnostics to engines, gas turbines, thermal and chemical plant systems, and disposal faciliti

  10. [Cultural detection of thermotolerant Campylobacter spp. in food--potentials and limitations of diagnostic tools in the context of official food control].

    Science.gov (United States)

    Messelhäusser, Ute; Thärigen, Diana; Fella, Christiane; Schreiner, Hermann; Busch, Ulrich; Höller, Christiane

    2015-01-01

    Thermotolerant Campylobacter spp. rank among the most important foodborne pathogens in Germany. Therefore a necessity for rapid and routinely useable detection methods exists also in the area of food microbiology. A reliable, cultura qualitative, but also quantitative detection of thermotolerant Campylobacter spp. pose a challenge, at least concerning special food matrices, especially because in the context of official food control the cultural detection of thermotolerant Campylobacter spp. is needed. This was the reason, why different cultural detection methods, beside the standard procedure of ISO 10272:2006, in combination with molecular and immunological screening methods were tested at the Bavarian Health and Food Safety Authority (LGL) during the last years for the use in routine diagnostic using different food matrices of animal and plant origin. The results of the comparative studies showed clearly that no enrichment broth tested gave completely satisfactory results for an only culture-based detection the combination with a screening method is therefore recommended for a rapid and reliable detection. But in this case the user should take into account that the sensitivity of such molecular and immunological methods is normally so high that in some cases, depending on the food matrix and processing step, the isolation of the pathogen would not be possible in samples, which were positive in the screening methods.

  11. Cardiovascular modeling and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kangas, L.J.; Keller, P.E.; Hashem, S.; Kouzes, R.T. [Pacific Northwest Lab., Richland, WA (United States)

    1995-12-31

    In this paper, a novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.

  12. Micobatteriological control of diagnostic instrumentation

    Directory of Open Access Journals (Sweden)

    Valeria Olivo

    2010-03-01

    Full Text Available Introduction: In addition to sterility testings for common bacteria, from 2006 on we have introduced in our laboratory sterility tests for mycobacteria on surgical instruments such as bronchoscope and lava-endoscope fluid used for their sterilization as well. Methods: Bronchology and Pneumology SUN departments, doing bronchoscopies, regularly send to our laboratory bronchoscopes washing fluids. Bronchology department also sends liquids used in lavaendoscopes. Our standard protocol consists of liquids inoculation directly on Lowenstein - Jensen (LJ solid ground and on Middlebrook 7H9 liquid medium into Mgit test tubes, both produced by Becton Dickinson, within 42 days (1, 5, 6. Results: When growth of acid-alcohol resistant bacilli was detected, they were identified through probes or Accuprobe bioMérieux Inno- LIPA Mycobacteria by Innogenetics. All positivite results were related to M. Gordonae. As for the liquids examined, we found one positivite result in liquid medium in 2006 and none in 2007. On the contrary, in 2008 and the first 6 months of 2009, we have identified the following positive results: 2008 - 2009 (6m LJ pos TOT 20 C. Lavaendoscope 8 V. 12 FBS We linked the positive findings on equipment with positivity for M. gordonae observed in patients undergoing bronchoscopy. Conclusions: Data analysis indicates within the period 2008-2009 we observed a recurring positivity for M. gordonae on equipment and therefore in some patients. On a careful evaluation, they showed no signs of clinical infection, also considering that this mycobacteria is usually a saprophyte (2, 3, 4. However, the protocol we adopted allowed us to recognize equipment contamination at birth and to urge fellow users to review sterilization protocols.

  13. ITER diagnostic system: Vacuum interface

    Energy Technology Data Exchange (ETDEWEB)

    Patel, K.M., E-mail: Kaushal.Patel@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Udintsev, V.S.; Hughes, S.; Walker, C.I.; Andrew, P.; Barnsley, R.; Bertalot, L. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Drevon, J.M. [Bertin Technologies, BP 22, 13762 Aix-en Provence cedex 3 (France); Encheva, A. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Kashchuk, Y. [Institution “PROJECT CENTER ITER”, 1, Akademika Kurchatova pl., Moscow (Russian Federation); Maquet, Ph. [Bertin Technologies, BP 22, 13762 Aix-en Provence cedex 3 (France); Pearce, R.; Taylor, N.; Vayakis, G.; Walsh, M.J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France)

    2013-10-15

    Diagnostics play an essential role for the successful operation of the ITER tokamak. They provide the means to observe control and to measure plasma during the operation of ITER tokamak. The components of the diagnostic system in the ITER tokamak will be installed in the vacuum vessel, in the cryostat, in the upper, equatorial and divertor ports, in the divertor cassettes and racks, as well as in various buildings. Diagnostic components that are placed in a high radiation environment are expected to operate for the life of ITER. There are approx. 45 diagnostic systems located on ITER. Some diagnostics incorporate direct or independently pumped extensions to maintain their necessary vacuum conditions. They require a base pressure less than 10{sup −7} Pa, irrespective of plasma operation, and a leak rate of less than 10{sup −10} Pa m{sup 3} s{sup −1}. In all the cases it is essential to maintain the ITER closed fuel cycle. These directly coupled diagnostic systems are an integral part of the ITER vacuum containment and are therefore subject to the same design requirements for tritium and active gas confinement, for all normal and accidental conditions. All the diagnostics, whether or not pumped, incorporate penetration of the vacuum boundary (i.e. window assembly, vacuum feedthrough etc.) and demountable joints. Monitored guard volumes are provided for all elements of the vacuum boundary that are judged to be vulnerable by virtue of their construction, material, load specification etc. Standard arrangements are made for their construction and for the monitoring, evacuating and leak testing of these volumes. Diagnostic systems are incorporated at more than 20 ports on ITER. This paper will describe typical and particular arrangements of pumped diagnostic and monitored guard volume. The status of the diagnostic vacuum systems, which are at the start of their detailed design, will be outlined and the specific features of the vacuum systems in ports and extensions

  14. Effectiveness of Trivalent Inactivated Influenza Vaccine in Children Estimated by a Test-Negative Case-Control Design Study Based on Influenza Rapid Diagnostic Test Results.

    Science.gov (United States)

    Shinjoh, Masayoshi; Sugaya, Norio; Yamaguchi, Yoshio; Tomidokoro, Yuka; Sekiguchi, Shinichiro; Mitamura, Keiko; Fujino, Motoko; Shiro, Hiroyuki; Komiyama, Osamu; Taguchi, Nobuhiko; Nakata, Yuji; Yoshida, Naoko; Narabayashi, Atsushi; Myokai, Michiko; Sato, Masanori; Furuichi, Munehiro; Baba, Hiroaki; Fujita, Hisayo; Sato, Akihiro; Ookawara, Ichiro; Tsunematsu, Kenichiro; Yoshida, Makoto; Kono, Mio; Tanaka, Fumie; Kawakami, Chiharu; Kimiya, Takahisa; Takahashi, Takao; Iwata, Satoshi

    2015-01-01

    We assessed vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age in 22 hospitals in Japan during the 2013-14 season. Our study was conducted according to a test-negative case-control design based on influenza rapid diagnostic test (IRDT) results. Outpatients who came to our clinics with a fever of 38 °C or over and had undergone an IRDT were enrolled in this study. Patients with positive IRDT results were recorded as cases, and patients with negative results were recorded as controls. Between November 2013 and March 2014, a total of 4727 pediatric patients (6 months to 15 years of age) were enrolled: 876 were positive for influenza A, 66 for A(H1N1)pdm09 and in the other 810 the subtype was unknown; 1405 were positive for influenza B; and 2445 were negative for influenza. Overall VE was 46% (95% confidence interval [CI], 39-52). Adjusted VE against influenza A, influenza A(H1N1)pdm09, and influenza B was 63% (95% CI, 56-69), 77% (95% CI, 59-87), and 26% (95% CI, 14-36), respectively. Influenza vaccine was not effective against either influenza A or influenza B in infants 6 to 11 months of age. Two doses of influenza vaccine provided better protection against influenza A infection than a single dose did. VE against hospitalization influenza A infection was 76%. Influenza vaccine was effective against influenza A, especially against influenza A(H1N1)pdm09, but was much less effective against influenza B.

  15. Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study

    Directory of Open Access Journals (Sweden)

    Swai Ndeniria

    2011-04-01

    Full Text Available Abstract Background Presumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic tests (mRDTs on prescription of anti-malarials in urban Tanzania. Methods The design was a prospective collection of routine statistics from ledger books and cross-sectional surveys before and after intervention in randomly selected health facilities (HF in Dar es Salaam, Tanzania. The participants were all clinicians and their patients in the above health facilities. The intervention consisted of training and introduction of mRDTs in all three hospitals and in six HF. Three HF without mRDTs were selected as matched controls. The use of routine mRDT and treatment upon result was advised for all patients complaining of fever, including children under five years of age. The main outcome measures were: (1 anti-malarial consumption recorded from routine statistics in ledger books of all HF before and after intervention; (2 anti-malarial prescription recorded during observed consultations in cross-sectional surveys conducted in all HF before and 18 months after mRDT implementation. Results Based on routine statistics, the amount of artemether-lumefantrine blisters used post-intervention was reduced by 68% (95%CI 57-80 in intervention and 32% (9-54 in control HF. For quinine vials, the reduction was 63% (54-72 in intervention and an increase of 2.49 times (1.62-3.35 in control HF. Before-and-after cross-sectional surveys showed a similar decrease from 75% to 20% in the proportion of patients receiving anti-malarial treatment (Risk ratio 0.23, 95%CI 0.20-0.26. The cluster randomized analysis showed a considerable difference of anti-malarial prescription between intervention HF (22% and control HF (60% (Risk ratio 0.30, 95%CI 0.14-0.70. Adherence to test result was excellent since only 7% of negative patients received an anti-malarial. However, antibiotic

  16. A guide for diagnostic evaluations

    NARCIS (Netherlands)

    R.W. Peeling; P.G. Smith; P.M.M. Bossuyt

    2010-01-01

    Accurate diagnostic tests have a key role in patient management and the control of most infectious diseases. Unfortunately, in many developing countries, clinical care is often critically compromised by the lack of regulatory controls on the quality of these tests. The information available on the p

  17. A guide for diagnostic evaluations

    NARCIS (Netherlands)

    R.W. Peeling; P.G. Smith; P.M.M. Bossuyt

    2006-01-01

    Accurate diagnostic tests have a key role in patient management and the control of most infectious diseases. Unfortunately, in many developing countries, clinical care is often critically compromised by the lack of regulatory controls on the quality of these tests. The information available on the p

  18. Diagnostics and Instrumentation for FEL

    CERN Document Server

    Couprie, M E

    2001-01-01

    Free Electron Laser are coherent sources of radiation based on the interaction of a relativistic electron beam in an undulator field. According to the energy of the accelerator, they presently cover a wide spectral range, from the infra-red to the VUV. FELs combine the diagnostics of typical laser systems (for the measurement of spectral and temporal characteristics, the transverse mode pattern, the polarisation) and the diagnostics of relativistic electron beams. The electron beam is characterised in order to evaluate and control the FEL performances, but also in order to measure the effect of the FEL on the electron beam. The FEL characteristics are monitored with various types of detectors, depending mainly on the spectral range. Diagnostics for Linac based Infra Red FELs and storage ring FELs in the UV-VUV will be described. Particular instrumentation, required for FEL operation, such as the optical resonator, possible diagnostics inside the undulator will also be analysed.

  19. Frequency of del(12p) is commonly underestimated in myelodysplastic syndromes: Results from a German diagnostic study in comparison with an international control group.

    Science.gov (United States)

    Braulke, Friederike; Müller-Thomas, Catharina; Götze, Katharina; Platzbecker, Uwe; Germing, Ulrich; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A N; Lübbert, Michael; Greenberg, Peter L; Bennett, John M; Solé, Francesc; Slovak, Marilyn L; Ohyashiki, Kazuma; Le Beau, Michelle M; Tüchler, Heinz; Pfeilstöcker, Michael; Hildebrandt, Barbara; Aul, Carlo; Stauder, Reinhard; Valent, Peter; Fonatsch, Christa; Bacher, Ulrike; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-12-01

    In myelodysplastic syndromes (MDS), deletion of the short arm of chromosome 12 (del(12p)) is usually a small abnormality, rarely detected as a single aberration by chromosome banding analysis (CBA) of bone marrow metaphases. Del(12p) has been described in 0.6 to 5% of MDS patients at initial diagnosis and is associated with a good to intermediate prognosis as a sole anomaly according to current scoring systems. Here, we present the results of a systematic del(12p) testing in a German prospective diagnostic study (clinicaltrials.gov: NCT01355913) on 367 MDS patients in whom CD34+ peripheral blood cells were analysed for the presence of del(12p) by sequential fluorescence in situ hybridization (FISH) analyses. A cohort of 2,902 previously published MDS patients diagnosed by CBA served as control. We demonstrate that, using a sensitive FISH technique, 12p deletion occurs significantly more frequently in MDS than previously described (7.6% by CD34+ PB-FISH vs. 1.6% by CBA, P < 0.001) and is often associated with other aberrations (93% by CD34+ PB-FISH vs. 60% by CBA). Additionally, the detection rate can be increased by repeated analyses in a patient over time which is important for the patient´s prognosis to distinguish a sole anomaly from double or complex aberrations. To our knowledge, this is the first study to screen for 12p deletions with a suitable probe for ETV6/TEL in 12p13. Our data suggest that the supplement of a probe for the detection of a 12p deletion to common FISH probe panels helps to avoid missing a del(12p), especially as part of more complex aberrations.

  20. Determinants of death among tuberculosis patients in a semi urban diagnostic and treatment centre of Bafoussam, West Cameroon: a retrospective case-control study.

    Science.gov (United States)

    Djouma, Fabrice Nembot; Noubom, Michel; Ngomba, Armelle Viviane; Donfack, Hubert; Kouomboua, Patrick Stéphane Mfin; Saah, Michael Amede Fopa

    2015-01-01

    Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. Despite the progress recorded in fighting against this disease in the recent years, Africa is still not on the track to achieve the objective to reduce by half the death rate due to this disease by 2015. A case-control study was conducted on data of patients admitted for tuberculosis between 1996 and 2011 in the Diagnostic and Treatment Center of Baleng. Cases were patients who died from any cause during anti tuberculosis treatment. Logistic regression model was used to identify factors associated to death. In 4201 patients treated during the study period, 3245 (77.24%) were included in the study. The mean age was 35.9 (SD 14.2) and male represent 62.2% (CI 60.6- 63.9) of them. At the end of the follow up, 2883 patients were successfully treated, 362 died during treatment and 132 (36.5%) deaths occurred during the first two months of TB treatment. HIV positive status, Extra-pulmonary TB, sputum smear-negative pulmonary TB and male sex were significant independent risk factors of death with adjusted odds ratio of 4.8 (CI 3.2- 7.4); 3.0 (CI 1.6- 5.4); 2.7 (CI 1.7- 4.4) and 1.5 (CI 1.0- 2.3) respectively. The mortality rate of TB patients undergoing TB treatment remains high. Studies are needed to identify and test efficient interventions of mortality reduction among TB patients in resource limiting settings.

  1. Can an EASYcare based dementia training programme improve diagnostic assessment and management of dementia by general practitioners and primary care nurses? The design of a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Lucassen PL

    2008-04-01

    Full Text Available Abstract Background Early diagnosis of dementia benefits both patient and caregiver. Nevertheless, dementia in primary care is currently under-diagnosed. Some educational interventions developed to improve dementia diagnosis and management were successful in increasing the number of dementia diagnoses and in changing attitudes and knowledge of health care staff. However, none of these interventions focussed on collaboration between GPs and nurses in dementia care. We developed an EASYcare-based Dementia Training Program (DTP aimed at stimulating collaboration in dementia primary care. We expect this program to increase the number of cognitive assessments and dementia diagnoses and to improve attitudes and knowledge of GPs and nurses. Methods The DTP is a complex educational intervention that consists of two workshops, a coaching program, access to an internet forum, and a Computerized Clinical Decision Support System on dementia diagnostics. One hundred duos of GPs and nurses will be recruited, from which 2/3 will be allocated to the intervention group and 1/3 to the control group. The effects of implementation of the DTP will be studied in a cluster-randomised controlled trial. Primary outcomes will be the number of cognitive assessments and dementia diagnoses in a period of 9 months following workshop participation. Secondary outcomes are measured on GP and nurse level: adherence to national guidelines for dementia, attitude, confidence and knowledge regarding dementia diagnosis and management; on patient level: number of emergency calls, visits and consultations and patient satisfaction; and on caregiver level: informal caregiver burden and satisfaction. Data will be collected from GPs' electronic medical records, self-registration forms and questionnaires. Statistical analysis will be performed using the MANOVA-method. Also, exploratory analyses will be performed, in order to gain insight into barriers and facilitators for implementation and

  2. Development and implantation of a control and data acquisition program for the calibration of instruments for diagnostic radiology; Desenvolvimento e implantacao de um programa de controle e aquisicao de dados na calibracao de instrumentos em radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Betti, Flavio

    2007-07-01

    Design techniques of an automatic control system implementing corrected kerma determination and shutter command in the calibration laboratory at IPEN are shown, as well as the periodic calibration program developed for a monitor chamber for several X-ray beam qualities used for diagnostic radiology and radiation protection instruments. Two reference electrometers, a multichannel secondary standard thermometer, and an absolute pressure barometer were connected to the Rs-232 interface from a PC computer equipped with a National Instruments multi function analog and digital I/O card. LabVIEW{sup MR} was chosen as programming tool, which allowed for the development of a suite of programs for both controlling the shutter timing cycles and the calibration of the monitor chamber against a reference standard. A detailed description of the methods used for troubleshooting, fine tuning of parameters and evaluation of program results is followed by an analysis showing that considerable advantages regarding reduction of time and precision improvements during the calibrations could be achieved by the use of the developed programs, particularly under adverse conditions like those found during short expositions, or instead during long irradiation intervals where fluctuation of parameters like kerma rate or room conditions (temperature or pressure) can be found. (author)

  3. Noninvasive express diagnostics of pulmonary diseases based on control of patient's gas emission using methods of IR and terahertz laser spectroscopy

    Science.gov (United States)

    Starikova, M. K.; Bulanova, A. A.; Bukreeva, E. B.; Karapuzikov, A. A.; Karapuzikov, A. I.; Kistenev, Y. V.; Klementyev, V. M.; Kolker, D. B.; Kuzmin, D. A.; Nikiforova, O. Y.; Ponomarev, Yu. N.; Sherstov, I. V.; Boyko, A. A.

    2013-11-01

    Pulmonary diseases diagnostics always occupies one of the key positions in medicine practices. A large variety of high technology methods are used today, but none of them cannot be used for early screening of pulmonary diseases. We discuss abilities of methods of IR and terahertz laser spectroscopy for noninvasive express diagnostics of pulmonary diseases on a base of analysis of absorption spectra of patient's gas emission, in particular, exhaled air. Experience in the field of approaches to experimental data analysis and hard-ware realization of gas analyzers for medical applications is also discussed.

  4. Validation of the academic management evaluation instru-ment based on principal component analysis for engineering and technological courses

    Directory of Open Access Journals (Sweden)

    Albano Oliveira Nunes

    2015-08-01

    Full Text Available In recent years, the expansion of higher education in Brazil has led to a series of demands related to aspects concerning training at the college level. These processes relate to: academics, professionals, entering in the labor market, among others. In this context, an important aspect is the quality of the courses. Thus, the evaluation becomes a critical diagnostic process of reality and starting point for possible interventions to be put in practice by the coordinators of the programs. This article presents the results of a questionnaire administered at the Federal University of Ceará (UFC, especially to  Systems & Digital Media and Engineering Programs professors. This research aims to identify how the professors from each department see the administrative procedures developed by the departments and also investigate the possibility of using Principal Components Analysis (PCA as a support for management of the higher education training. The methodology included the implementation of Likert scale questionnaire and subsequent mathematical treatment with PCA. The results indicate the potential application of PCA to support the management of higher education; it was possible to extract preliminaries inferences related to management methods and their characteristics. This suggests the possibility of developing the Educametrics field.

  5. Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

    DEFF Research Database (Denmark)

    Albert, Nathalie L; Unterrainer, Marcus; Diemling, Markus

    2016-01-01

    PURPOSE: Even though [(123)I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS...

  6. The Eating Disorder Diagnostic Scale: psychometric features within a clinical population and a cut-off point to differentiate clinical patients from healthy controls

    NARCIS (Netherlands)

    Krabbenborg, M.A.M.; Danner, U.N.; Larsen, J.K.; Veer, N. van der; Elburg, A.A. van; Ridder, D.T. de; Evers, C.; Stice, E.; Engels, R.C.E.M.

    2012-01-01

    The Eating Disorder Diagnostic Scale (EDDS) is a brief self-report measure for diagnosing anorexia nervosa, bulimia nervosa and binge eating disorder. Research has provided evidence of the reliability and validity of this scale in non-clinical populations. Our study is the first to examine the

  7. The Eating Disorder Diagnostic Scale: psychometric features within a clinical population and a cut-off point to differentiate clinical patients from healthy controls

    NARCIS (Netherlands)

    Krabbenborg, M.A.M.; Danner, U.N.; Larsen, J.K.; Veer, N. van der; Elburg, A.A. van; Ridder, D.T. de; Evers, C.; Stice, E.; Engels, R.C.E.M.

    2012-01-01

    The Eating Disorder Diagnostic Scale (EDDS) is a brief self-report measure for diagnosing anorexia nervosa, bulimia nervosa and binge eating disorder. Research has provided evidence of the reliability and validity of this scale in non-clinical populations. Our study is the first to examine the psych

  8. [Diagnostic dyspraxia and frontal syndrome].

    Science.gov (United States)

    Donnet, A; Schmitt, A; Poncet, M

    1998-05-01

    A 27-year-old ambidexter woman experienced a clinical and psychometric frontal syndrome associated with a partial callosal syndrome following transcallosal surgery for an intraventricular neurocytoma. She also complained of difficulties with her left hand which realized a particular form of diagnostic dyspraxia: there were specific features of an isolated dysfunction of the control of the realization of a program.

  9. Thioaptamer Diagnostic System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AM Biotechnologies (AM) will develop a diagnostic system in response to SBIR Topic X10.01 Reusable Diagnostic Lab Technology that will simultaneously detect and...

  10. Diagnostic Algorithm Benchmarking

    Science.gov (United States)

    Poll, Scott

    2011-01-01

    A poster for the NASA Aviation Safety Program Annual Technical Meeting. It describes empirical benchmarking on diagnostic algorithms using data from the ADAPT Electrical Power System testbed and a diagnostic software framework.

  11. Diagnostics procedures in rabies

    Directory of Open Access Journals (Sweden)

    Malovrh Tadej

    2005-01-01

    Full Text Available Rabies is a major zoonosis for which diagnostic techniques can only be performed in the laboratory. Laboratory techniques are preferably oriented on tissue removed from the cranium: hippocampus (Ammon's horn, cerebellum and the medulla oblongata or tissue liquids. Clinical observation may only lead to a suspicion of rabies. The only way to perform a reliable diagnosis of the disease is to identify the virus or some of its specific components using laboratory tests such as histological identification of characteristic cell lesions, immunochemical identification of rabies virus antigen and virus isolation. Serological tests are rarely used in epidemiological surveys but much more frequently in control of the vaccination programs (e.g. oral vaccination. Most commonly used serological tests are the virus neutralization test on cell culture (FAVN, virus neutralization in mice and ELISA.

  12. Survey of diagnostic and typing capacity for Clostridium difficile infection in Europe, 2011 and 2014

    NARCIS (Netherlands)

    Van Dorp, S. M.; Notermans, D. W.; Alblas, J.; Gastmeier, P.; Mentula, S.; Nagy, E.; Spigaglia, P.; Ivanova, K.; Fitzpatrick, F.; Barbut, F.; Morris, T.; Wilcox, M. H.; Kinross, P.; Suetens, C.; Kuijper, E. J.

    2016-01-01

    Suboptimal laboratory diagnostics for Clostridium difficile infection (CDI) impedes its surveillance and control across Europe. We evaluated changes in local laboratory CDI diagnostics and changes in national diagnostic and typing capacity for CDI during the European C. difficile Infection Surveilla

  13. Implementation of the European multicentre database of healthy controls for [{sup 123}I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Nathalie L.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter; Koch, Walter [University of Munich, Department of Nuclear Medicine, Munich (Germany); Diemling, Markus [Hermes Medical Solutions, Stockholm (Sweden); Varrone, Andrea [Karolinska University Hospital, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (Sweden); Dickson, John C. [UCLH NHS Foundation Trust and University College, Institute of Nuclear Medicine, London (United Kingdom); Tossici-Bolt, Livia [University Hospitals Southampton NHS Trust, Department of Medical Physics, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Asenbaum, Susanne [Medical University of Vienna, Department of Neurology, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, L. Oezlem A. [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Kluge, Andreas [ABX-CRO, Dresden (Germany); Ziebell, Morten [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Darcourt, Jacques [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Clinical Neurology Unit, Department of Neuroscience (DINOGMI), Genoa (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, CNR, Rome (Italy); Karolinska Hospital, Department of Nuclear medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Hesse, Swen [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Molecular Neuroimaging IFB Adiposity Diseases, Leipzig (Germany); Borght, Thierry vander [Universite Catholique de Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Tatsch, Klaus [Staedtisches Klinikum Karlsruhe, Department of Nuclear Medicine, Karlsruhe (Germany); La Fougere, Christian [University of Tuebingen, Division of Nuclear Medicine, Department of Radiology, Tuebingen (Germany)

    2016-07-15

    Even though [{sup 123}I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS with previously inconclusive findings can be improved by the use of iterative reconstruction algorithms and an improved semiquantitative evaluation which additionally implemented a correction algorithm for patient age and gamma camera dependency (EARL-BRASS; Hermes Medical Solutions, Sweden). We identified 101 patients with inconclusive findings who underwent an [{sup 123}I]FP-CIT SPECT between 2003 and 2010 as part of the diagnostic process of suspected PS at the University of Munich, and re-evaluated these scans using iterative reconstruction algorithms and the new corrected EARL-BRASS. Clinical follow-up was obtained in 62 out of the 101 patients and constituted the gold standard for the re-evaluation to assess the possible improvement in diagnostic accuracy. Clinical follow-up confirmed the diagnosis of PS in 11 of the 62 patients. In patients in whom both visual and semiquantitative analysis showed concordant findings (48 patients), a high negative predictive value (93 %), positive predictive value (100 %) and accuracy (94 %) were found, and thus a correct diagnosis was obtained in 45 of the 48 patients. Among the 14 patients with discordant findings, the additional semiquantitative analysis correctly identified all five of nine patients patients without PS by nonpathological semiquantitative findings in visually pathological or inconclusive scans. In contrast, four of the remaining five patients with decreased semiquantitative values but visually normal scans did not show a PS during follow-up. The age-corrected and camera-corrected mode of evaluation using EARL-BRASS provided a notable improvement in the diagnostic accuracy of [{sup 123}I]FP-CIT SPECT in PS patients with

  14. Use of rapid diagnostic tests in malaria school surveys in Kenya: does their under-performance matter for planning malaria control?

    Science.gov (United States)

    Gitonga, Caroline W; Kihara, Jimmy H; Njenga, Sammy M; Awuondo, Ken; Noor, Abdisalan M; Snow, Robert W; Brooker, Simon J

    2012-12-01

    Malaria rapid diagnostic tests (RDTs) are known to yield false-positive results, and their use in epidemiologic surveys will overestimate infection prevalence and potentially hinder efficient targeting of interventions. To examine the consequences of using RDTs in school surveys, we compared three RDT brands used during a nationwide school survey in Kenya with expert microscopy and investigated the cost implications of using alternative diagnostic approaches in identifying localities with differing levels of infection. Overall, RDT sensitivity was 96.1% and specificity was 70.8%. In terms of classifying districts and schools according to prevalence categories, RDTs were most reliable for the 40% categories and least reliable in the 1-4.9% category. In low-prevalence settings, microscopy was the most expensive approach, and RDT results corrected by either microscopy or polymerase chain reaction were the cheapest. Use of polymerase chain reaction-corrected RDT results is recommended in school malaria surveys, especially in settings with low-to-moderate malaria transmission.

  15. Design of New Physiotherapy Instrument Based on PWM%基于PWM的新型理疗仪设计

    Institute of Scientific and Technical Information of China (English)

    陈海军; 温志浩

    2013-01-01

    STM32 as the main chip, we design a novel electrical pulse physiotherapy instrument which realize pulse width modulation (PWM) by timer set ing, then get the needed treatment waveform after signal conditioning, power ampliifer, and output control. The experimental results show that, physiotherapy instrument is stable and reliable, physical strength large adjustable range, which can be suitable for the vast majority of the crowd;and the output waveform is smooth, without burr, there were no obvious pain, obvious physical therapy effect.%利用S T M32作为主控芯片,设计了一种新型中频电脉冲理疗仪,通过微秒级定时器设置实现高精度脉宽调制(P W M)功能,经过信号调理、功率放大以及输出控制得到所需要的治疗波形。实验结果表明,理疗仪工作稳定可靠,理疗强度可调幅度大,可适合绝大多数人群;输出波形光滑、无毛刺、病人无明显刺痛感,理疗效果明显。

  16. Intensity-Stabilized Fast-Scanned Direct Absorption Spectroscopy Instrumentation Based on a Distributed Feedback Laser with Detection Sensitivity down to 4 × 10−6

    Science.gov (United States)

    Zhao, Gang; Tan, Wei; Jia, Mengyuan; Hou, Jiajuan; Ma, Weiguang; Dong, Lei; Zhang, Lei; Feng, Xiaoxia; Wu, Xuechun; Yin, Wangbao; Xiao, Liantuan; Axner, Ove; Jia, Suotang

    2016-01-01

    A novel, intensity-stabilized, fast-scanned, direct absorption spectroscopy (IS-FS-DAS) instrumentation, based on a distributed feedback (DFB) diode laser, is developed. A fiber-coupled polarization rotator and a fiber-coupled polarizer are used to stabilize the intensity of the laser, which significantly reduces its relative intensity noise (RIN). The influence of white noise is reduced by fast scanning over the spectral feature (at 1 kHz), followed by averaging. By combining these two noise-reducing techniques, it is demonstrated that direct absorption spectroscopy (DAS) can be swiftly performed down to a limit of detection (LOD) (1σ) of 4 × 10−6, which opens up a number of new applications. PMID:27657082

  17. Intensity-Stabilized Fast-Scanned Direct Absorption Spectroscopy Instrumentation Based on a Distributed Feedback Laser with Detection Sensitivity down to 4 × 10−6

    Directory of Open Access Journals (Sweden)

    Gang Zhao

    2016-09-01

    Full Text Available A novel, intensity-stabilized, fast-scanned, direct absorption spectroscopy (IS-FS-DAS instrumentation, based on a distributed feedback (DFB diode laser, is developed. A fiber-coupled polarization rotator and a fiber-coupled polarizer are used to stabilize the intensity of the laser, which significantly reduces its relative intensity noise (RIN. The influence of white noise is reduced by fast scanning over the spectral feature (at 1 kHz, followed by averaging. By combining these two noise-reducing techniques, it is demonstrated that direct absorption spectroscopy (DAS can be swiftly performed down to a limit of detection (LOD (1σ of 4 × 10−6, which opens up a number of new applications.

  18. Diagnostic Development on NSTX

    Energy Technology Data Exchange (ETDEWEB)

    A.L. Roquemore; D. Johnson; R. Kaita; et al

    1999-12-16

    Diagnostics are described which are currently installed or under active development for the newly commissioned NSTX device. The low aspect ratio (R/a less than or equal to 1.3) and low toroidal field (0.1-0.3T) used in this device dictate adaptations in many standard diagnostic techniques. Technical summaries of each diagnostic are given, and adaptations, where significant, are highlighted.

  19. 40 CFR 86.005-17 - On-board diagnostics.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false On-board diagnostics. 86.005-17... Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.005-17 On-board diagnostics. (a) General... “Road Vehicles-Diagnostics on Controller Area Network (CAN)—Part 4: Requirements for...

  20. DIAGNOSTICS OF A MODERN CAR

    Directory of Open Access Journals (Sweden)

    Khrapov Y. N.

    2016-04-01

    Full Text Available The article presents a technical diagnostics of a car as a complex of goals and tasks connected with trouble-shooting of mechanisms and systems in order to eliminate them. We have considered the stages of computer diagnostics of different automobile systems such as diagnosing the engine, the brake system, steering and suspension. We have analyzed their components, the ways of troubleshooting and elimination recommendations. The article presents the main troubles transferred from the electronic control unit. The article also presents the stages of diagnosing the engine including external examination, listening to abnormal noises, checking the operating fluids and the engine management system, diagnosing the basic engine systems and checking the cylinders being filled. The article contains the list of main troubles and their reasons. One can also see diagnosing the brake system, its defects and remedies. The article presents diagnostics and repair of the suspender and graphics describing the check of the dismantled shock strut at the stand and tests of the shock strut without being dismantled. We have analyzed computer diagnostics and the problems it solves

  1. Diagnostics of Nanodusty Plasma

    Science.gov (United States)

    Greiner, Franko; Groth, Sebastian; Tadsen, Bejamin; Piel, Alexander

    2015-11-01

    The diagnostic of nanodusty plasmas, i.e. plasmas including nano-sized dust particles, is a challenging task. For both, the diagnostic of the nanodusty plasma itself, and the in-situ diagnostic of the nanoparticles, no standard diagnostic exist. Nanodust particle size and density can be estimated using light scattering techniques, namely kinetic Mie ellipsometry and extinction measurements. The charge of the nanoparticles can be estimated from the analysis of dust density waves (DDW). Parameters like the electron density, which give information about the plasma itself, may be deduced from the DDW analysis. We present detailed investigations on nanodust in a reactive Argon-Acetylene plasma created in an rf-driven parallel plate reactor at low pressure using the above mentioned portfolio of diagnostic. Funded by DFG under contract SFB TR-24/A2.

  2. Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study.

    Directory of Open Access Journals (Sweden)

    Janjira Thaipadungpanit

    Full Text Available BACKGROUND: Rapid PCR-based tests for the diagnosis of leptospirosis can provide information that contributes towards early patient management, but these have not been adopted in Thailand. Here, we compare the diagnostic sensitivity and specificity of two real-time PCR assays targeting rrs or lipL32 for the diagnosis of leptospirosis in northeast Thailand. METHODS/PRINCIPAL FINDINGS: A case-control study of 266 patients (133 cases of leptospirosis and 133 controls was constructed to evaluate the diagnostic sensitivity and specificity (DSe & DSp of both PCR assays. The median duration of illness prior to admission of cases was 4 days (IQR 2-5 days; range 1-12 days. DSe and DSp were determined using positive culture and/or microscopic agglutination test (MAT as the gold standard. The DSe was higher for the rrs assay than the lipL32 assay (56%, (95% CI 47-64% versus 43%, (95% CI 34-52%, p<0.001. No cases were positive for the lipL32 assay alone. There was borderline evidence to suggest that the DSp of the rrs assay was lower than the lipL32 assay (90% (95% CI 83-94% versus 93%, (95%CI 88-97%, p = 0.06. Nine controls gave positive reactions for both assays and 5 controls gave a positive reaction for the rrs assay alone. The DSe of the rrs and lipL32 assays were high in the subgroup of 39 patients who were culture positive for Leptospira spp. (95% and 87%, respectively, p = 0.25. CONCLUSIONS/SIGNIFICANCE: Early detection of Leptospira using PCR is possible for more than half of patients presenting with leptospirosis and could contribute to individual patient care.

  3. Evaluation of Commercial Diagnostic Assays for the Specific Detection of Avian Influenza A (H7N9) Virus RNA Using a Quality-Control Panel and Clinical Specimens in China

    Science.gov (United States)

    Chen, Suhong; Wang, Dayan; Li, Changgui; Wu, Xing; Li, Lili; Bai, Dongting; Zhang, Chuntao; Wang, Junzhi

    2015-01-01

    A novel avian influenza A H7N9-subtype virus emerged in China in 2013 and threatened global public health. Commercial kits that specifically detect avian influenza A (H7N9) virus RNA are urgently required to prepare for the emergence and potential pandemic of this novel influenza virus. The safety and effectiveness of three commercial molecular diagnostic assays were evaluated using a quality-control panel and clinical specimens collected from over 90 patients with confirmed avian influenza A (H7N9) virus infections. The analytical performance evaluation showed that diverse influenza H7N9 viruses can be detected with high within- and between-lot reproducibility and without cross-reactivity to other influenza viruses (H1N1 pdm09, seasonal H1N1, H3N2, H5N1 and influenza B). The detection limit of all the commercial assays was 2.83 Log10 copies/μl [0.7 Log10TCID50/mL of avian influenza A (H7N9) virus strain A/Zhejiang/DTID-ZJU01/2013], which is comparable to the method recommended by the World Health Organization (WHO). In addition, using a WHO-Chinese National Influenza Center (CNIC) method as a reference for clinical evaluation, positive agreement of more than 98% was determined for all of the commercial kits, while negative agreement of more than 99% was observed. In conclusion, our findings provide comprehensive evidence for the high performance of three commercial diagnostic assays and suggest the application of these assays as rapid and effective diagnostic tools for avian influenza A (H7N9) virus in the routine clinical practice of medical laboratories. PMID:26361351

  4. Battling malaria in rural Zambia with modern technology: a qualitative study on the value of cell phones, geographical information systems, asymptomatic carriers and rapid diagnostic tests to identify, treat and control malaria

    Directory of Open Access Journals (Sweden)

    David Nygren

    2014-02-01

    Full Text Available During the last decade much progress has been made in reducing malaria transmission in Macha, Southern Province, Zambia. Introduction of artemisinin combination therapies as well as mass screenings of asymptomatic carriers is believed to have contributed the most. When an endemic malaria situation is moving towards a non-endemic situation the resident population loses acquired immunity and therefore active case detection and efficient surveillance is crucial to prevent epidemic outbreaks. Our purpose was to evaluate the impact of cell phone surveillance and geographical information systems on malaria control in Macha. Furthermore, it evaluates what screening and treatment of asymptomatic carriers and implementation of rapid diagnostic tests in rural health care has led to. Ten in-depth semistructured interviews, field observations and data collection were performed at the Macha Research Trust and at surrounding rural health centers. This qualitative method was inspired by rapid assessment procedure. The cell phone surveillance has been easily integrated in health care, and its integration with Geographical Information Systems has provided the ability to follow malaria transmission on a weekly basis. In addition, active case detection of asymptomatic carriers has been fruitful, which is reflected in it soon being applied nationwide. Furthermore, rapid diagnostic tests have provided rural health centers with reliable malaria diagnostics, thereby decreasing excessive malaria treatments and selection for drug resistance. This report reflects the importance of asymptomatic carriers in targeting malaria elimination, as well as development of effective surveillance systems when transmission decreases. Such an approach would be cost-efficient in the long run through positive effects in reduced child mortality and relief in health care.

  5. Nova alignment and laser diagnostics systems - 1

    Energy Technology Data Exchange (ETDEWEB)

    Bliss, E.S.; Ozarski, R.G.; Myers, D.W.; Richards, J.B.; Swift, C.D.; Boyd, R.D.; Hugenberger, R.E.; Seppala, L.G.; Parker, J.; Dryden, E.H.

    1981-01-01

    The alignment and laser diagnostic systems guide laser pulses through the separate amplifier chains to the target, measure their temporal, spatial and energy characteristics, and ensure simultaneous arrival at the target to within 5 picoseconds. Alignment tasks accomplished prior to each target shot involve automatic or remote-manual adjustments of approximately 2000 stepper motors and other actuators for the full 20 beam, 3 wavelength system. The primary detectors for alignment functions are CCD cameras with both digital and standard video output. Diagnostic data handling and processing is accomplished digitally, and both the alignment and diagnostic systems are integrated into the facility-wide digital control network.

  6. Diagnostics in critical conditions

    Directory of Open Access Journals (Sweden)

    SadchikovD.V.

    2011-09-01

    Full Text Available The purpose of research: improvement of quality of diagnostics at the patients in a critical condition in intensive care unit. Material and methods. In total have analyzed 1957 medical cards of the patients who have died in ICU»s. At the first stage studied the factors influencing on diagnostics of critically ill patients (medical cards of 1557 patients; at the second stage investigated influence of the diagnostic standards in ICU»s practice on improvement of quality of diag- nostics of critically ill patients (400 medical cards of the patients who have died. Entry criterions were standards and algorithm of diagnostics. Techniques of research: average bed-day in groups, first-day lethality, quantity of the carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II scores. Results. Quality of diagnostics depend on carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II score. The conclusion. The laboratory tests and tool methods of research conforming to the standards of diagnostics are necessary for improvement of quality of diagnostics, it is necessary to take into account an altered level of consciousness (Glasgow come score and severity of disease by ICU»s patients (APACHE II scores

  7. Intelligent systems in technical and medical diagnostics

    CERN Document Server

    Korbicz, Jozef

    2013-01-01

    For many years technical and medical diagnostics has been the area of intensive scientific research. It covers well-established topics as well as emerging developments in control engineering, artificial intelligence, applied mathematics, pattern recognition and statistics. At the same time, a growing number of applications of different fault diagnosis methods, especially in electrical, mechanical, chemical and medical engineering, is being observed. This monograph contains a collection of 44 carefully selected papers contributed by experts in technical and medical diagnostics, and constitutes

  8. [Recent development of microfluidic diagnostic technologies].

    Science.gov (United States)

    Li, Haifang; Zhang, Qianyun; Lin, Jin-Ming

    2011-04-01

    Microfluidic devices exhibit a great promising development in clinical diagnosis and disease screening due to their advantages of precise controlling of fluid flow, requirement of miniamount sample, rapid reaction speed and convenient integration. In this paper, the improvements of microfluidic diagnostic technologies in recent years are reviewed. The applications and developments of on-chip disease marker detection, microfluidic cell selection and cell drug metabolism, and diagnostic micro-devices are discussed.

  9. Cable Diagnostic Focused Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Hartlein, R.A.; Hampton, R.N.

    2010-12-30

    This report summarizes an extensive effort made to understand how to effectively use the various diagnostic technologies to establish the condition of medium voltage underground cable circuits. These circuits make up an extensive portion of the electric delivery infrastructure in the United States. Much of this infrastructure is old and experiencing unacceptable failure rates. By deploying efficient diagnostic testing programs, electric utilities can replace or repair circuits that are about to fail, providing an optimal approach to improving electric system reliability. This is an intrinsically complex topic. Underground cable systems are not homogeneous. Cable circuits often contain multiple branches with different cable designs and a range of insulation materials. In addition, each insulation material ages differently as a function of time, temperature and operating environment. To complicate matters further, there are a wide variety of diagnostic technologies available for assessing the condition of cable circuits with a diversity of claims about the effectiveness of each approach. As a result, the benefits of deploying cable diagnostic testing programs have been difficult to establish, leading many utilities to avoid the their use altogether. This project was designed to help address these issues. The information provided is the result of a collaborative effort between Georgia Tech NEETRAC staff, Georgia Tech academic faculty, electric utility industry participants, as well as cable system diagnostic testing service providers and test equipment providers. Report topics include: •How cable systems age and fail, •The various technologies available for detecting potential failure sites, •The advantages and disadvantages of different diagnostic technologies, •Different approaches for utilities to employ cable system diagnostics. The primary deliverables of this project are this report, a Cable Diagnostic Handbook (a subset of this report) and an online

  10. Melioidosis Diagnostic Workshop, 20131

    Science.gov (United States)

    AuCoin, David; Baccam, Prasith; Baggett, Henry C.; Baird, Rob; Bhengsri, Saithip; Blaney, David D.; Brett, Paul J.; Brooks, Timothy J.G.; Brown, Katherine A.; Chantratita, Narisara; Cheng, Allen C.; Dance, David A.B.; Decuypere, Saskia; Defenbaugh, Dawn; Gee, Jay E.; Houghton, Raymond; Jorakate, Possawat; Lertmemongkolchai, Ganjana; Limmathurotsakul, Direk; Merlin, Toby L.; Mukhopadhyay, Chiranjay; Norton, Robert; Peacock, Sharon J.; Rolim, Dionne B.; Simpson, Andrew J.; Steinmetz, Ivo; Stoddard, Robyn A.; Stokes, Martha M.; Sue, David; Tuanyok, Apichai; Whistler, Toni; Wuthiekanun, Vanaporn; Walke, Henry T.

    2015-01-01

    Melioidosis is a severe disease that can be difficult to diagnose because of its diverse clinical manifestations and a lack of adequate diagnostic capabilities for suspected cases. There is broad interest in improving detection and diagnosis of this disease not only in melioidosis-endemic regions but also outside these regions because melioidosis may be underreported and poses a potential bioterrorism challenge for public health authorities. Therefore, a workshop of academic, government, and private sector personnel from around the world was convened to discuss the current state of melioidosis diagnostics, diagnostic needs, and future directions. PMID:25626057

  11. Dichroic beamsplitter for high energy laser diagnostics

    Science.gov (United States)

    LaFortune, Kai N; Hurd, Randall; Fochs, Scott N; Rotter, Mark D; Hackel, Lloyd

    2011-08-30

    Wavefront control techniques are provided for the alignment and performance optimization of optical devices. A Shack-Hartmann wavefront sensor can be used to measure the wavefront distortion and a control system generates feedback error signal to optics inside the device to correct the wavefront. The system can be calibrated with a low-average-power probe laser. An optical element is provided to couple the optical device to a diagnostic/control package in a way that optimizes both the output power of the optical device and the coupling of the probe light into the diagnostics.

  12. Identifying developmental coordination disorder: MOQ-T validity as a fast screening instrument based on teachers' ratings and its relationship with praxic and visuospatial working memory deficits.

    Science.gov (United States)

    Giofrè, David; Cornoldi, Cesare; Schoemaker, Marina M

    2014-12-01

    The present study was devoted to test the validity of the Italian adaptation of the Motor Observation Questionnaire for Teachers (MOQ-T, Schoemaker, Flapper, Reinders-Messelink, & De Kloet, 2008) as a fast screening instrument, based on teachers' ratings, for detecting developmental coordination disorders symptoms and to study its relationship with praxic and visuospatial working memory deficits. In a first study on a large sample of children, we assessed the reliability and structure of the Italian adaptation of the MOQ-T. Results showed a good reliability of the questionnaire and a hierarchical structure with two first-order factors (reflecting motor and handwriting skills), which are influenced by a second-order factor (general motor function) at the top. In a second study, we looked at the external validity of the MOQ-T and found that children with symptoms of Developmental Coordination Disorder (children with high scores on the MOQ-T) also had difficulty reproducing gestures, either imitating others or in response to verbal prompts. Our results also showed that children with high MOQ-T scores had visuospatial WM impairments. The theoretical and clinical implications of these findings are discussed.

  13. 基于Python的虚拟仪器技术研究及实现%Development and research of virtual instrument based on Python

    Institute of Scientific and Technical Information of China (English)

    陈笑飞; 李滔

    2012-01-01

    Basing on such as efficient, flexible, object-oriented features of Python, combining PYQT and NumPy's powerful abilities, the users can easily modify the program code to increase or decrease the instrument system function or scale according to their needs , through the method of abstracting instances of classes from item objects or action functions. In this way, we can simplify the development process and reuse code efficiently. The examples show that the development of virtual instrument based on Python is distinctive nuance, its cycle is short, and has broad research prospects.%基于Python语言高效、灵活、面向对象等特性,结合PYQT以及NumPy等扩展模块提供的强大功能.通过将控件对象及回调函数抽象为相应的类实例,使用户可以根据自身需求方便地修改程序代码以增减仪器的系统功能或规模,简化虚拟仪器开发过程,有效实现代码的重复利用,并通过实例表明,用Python开发虚拟仪器层次清晰,周期短,具有广泛的研究前景。

  14. Thioaptamer Diagnostic System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AM Biotechnologies (AM) in partnership with Sandia National Laboratories will develop a Thioaptamer Diagnostic System (TDS) in response to Topic X10.01 Reusable...

  15. Rotorcraft Diagnostics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Under this SBIR program, Ridgetop will introduce the first low-cost, low-power, and lightweight data monitoring solution for rotorcraft diagnostics. The solution is...

  16. National Convective Weather Diagnostic

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current convective hazards identified by the National Convective Weather Detection algorithm. The National Convective Weather Diagnostic (NCWD) is an automatically...

  17. Prenatal Genetic Diagnostic Tests

    Science.gov (United States)

    ... are offered to all pregnant women. What is amniocentesis? Amniocentesis is a diagnostic test. It usually is done ... a very small chance of pregnancy loss with amniocentesis. Leakage of amniotic fluid and slight bleeding can ...

  18. 重型汽车控制系统的通讯与诊断协议%Communication and Diagnostic Protocol of Control System on Heavy-duty Vehicle

    Institute of Scientific and Technical Information of China (English)

    程军

    2001-01-01

    为了便于汽车上越来越多的控制系统之间的相互通讯,现代汽车上采用了多通道网络技术。简要介绍了用于重型汽车控制系统网络技术的通讯与诊断协议SAE、J1708、SAE、J1587、SAE、J1922、ISO、9141、ISO、14230。%Multi-tunnel network technology are adopted in modern auto to the intercommunic ation of the control systems.This paper introduces the network technology of con trol system and the diagnostic protocol SAE、J1708,SAE、J1587,SAE、J1922,ISO、91 41,ISO、14230 used in the heavy-duty vehicle.

  19. [Diagnostics in osteology].

    Science.gov (United States)

    Jakob, F; Genest, F; Seefried, L; Tsourdi, E; Lapa, C; Hofbauer, L C

    2016-07-01

    Clinical diagnostics in metabolic bone diseases cover a broad spectrum of conventional and state of the art methods ranging from the medical history and clinical examination to molecular imaging. Patient treatment is carried out in an interdisciplinary team due to the multiple interactions of bone with other organ systems. Diagnosis of osteoporosis is supported by high level national guidelines. A paradigm shift concerning the clinical relevance of bone mineral density measurement renders this now to be a strong risk factor rather than a diagnostic parameter, while strengthening the value of other clinical factors for risk assessment. The impact of parameters for muscle mass, structure and function is steadily increasing in all age groups. In order to identify underlying diseases that influence bone metabolism a panel of general laboratory diagnostic parameters is recommended. Markers for bone formation and resorption and specific parameters for the regulation of calcium and phosphate metabolism should be evaluated by specialists because they require diligence in preanalytics and experience in interpretation. Genetic diagnosis is well established for rare bone diseases while diagnostic panels are not yet available for routine diagnostics in polygenetic diseases such as osteoporosis. Conventional radiology is still very important to identify, e. g. fractures, osteolytic and osteoblastic lesions and extraosseous calcifications; however tomography-based methods which combine, e. g. scintigraphy or positron emission technologies with anatomical imaging are of increasing significance. Clinical diagnostics in osteology require profound knowledge and are subject to a dynamic evolution.

  20. Effect of Keishibukuryogan on Endothelial Function in Patients with at Least One Component of the Diagnostic Criteria for Metabolic Syndrome: A Controlled Clinical Trial with Crossover Design

    Directory of Open Access Journals (Sweden)

    Yutaka Nagata

    2012-01-01

    Full Text Available We evaluated the effect of keishibukuryogan (KBG; Guizhi-Fuling-Wan, a traditional Japanese (Kampo formula, on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (Endo-PAT2000 in patients with metabolic syndrome-related factors by controlled clinical trial with crossover design. Ninety-two patients were assigned to group A (first KBG-treatment period, then control period; each lasting 4 weeks, with about one-year interval or group B (first control, then KBG-treatment. In forty-nine (27, group A; 22, group B patients completing all tests, the mean value of the natural logarithmic-scaled reactive hyperemia index (L_RHI increased and those of serum nonesterified fatty acid (NEFA, malondialdehyde, and soluble vascular cell adhesion molecule 1 decreased significantly during the KBG-treatment period, but not during the control period, and 4-week changes of L_RHI, NEFA, and malondialdehyde between the 2 periods showed significance. These results suggest that KBG has beneficial effect on endothelial function in patients with metabolic syndrome-related factors.

  1. Optics/Optical Diagnostics Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Optics/Optical Diagnostics Laboratory supports graduate instruction in optics, optical and laser diagnostics and electro-optics. The optics laboratory provides...

  2. Proposed diagnostic criteria for internet addiction.

    Science.gov (United States)

    Tao, Ran; Huang, Xiuqin; Wang, Jinan; Zhang, Huimin; Zhang, Ying; Li, Mengchen

    2010-03-01

    The objective of this study was to develop diagnostic criteria for internet addiction disorder (IAD) and to evaluate the validity of our proposed diagnostic criteria for discriminating non-dependent from dependent internet use in the general population. This study was conducted in three stages: the developmental stage (110 subjects in the survey group; 408 subjects in the training group), where items of the proposed diagnostic criteria were developed and tested; the validation stage (n = 405), where the proposed criteria were evaluated for criterion-related validity; and the clinical stage (n = 150), where the criteria and the global clinical impression of IAD were evaluated by more than one psychiatrist to determine inter-rater reliability. The proposed internet addiction diagnostic criteria consisted of symptom criterion (seven clinical symptoms of IAD), clinically significant impairment criterion (functional and psychosocial impairments), course criterion (duration of addiction lasting at least 3 months, with at least 6 hours of non-essential internet usage per day) and exclusion criterion (exclusion of dependency attributed to psychotic disorders). A diagnostic score of 2 + 1, where the first two symptoms (preoccupation and withdrawal symptoms) and at least one of the five other symptoms (tolerance, lack of control, continued excessive use despite knowledge of negative effects/affects, loss of interests excluding internet, and use of the internet to escape or relieve a dysphoric mood) was established. Inter-rater reliability was 98%. Our findings suggest that the proposed diagnostic criteria may be useful for the standardization of diagnostic criteria for IAD.

  3. ULTRASOUND DIAGNOSTICS OF RETROCERVICAL ENDOMETRIOSIS

    Directory of Open Access Journals (Sweden)

    R. A. Barto

    2015-01-01

    Full Text Available Background: Endometriosis is one of the major problems in current gynecology due to steady increase of its incidence, involvement of young females, high frequency of infertility and difficulties with diagnostics and treatment. Confirmation of diagnosis of advanced endometriosis is still within the competence of research centers and big federal treatment establishments.Aim: To improve ultrasound diagnostics and to develop an algorithm of assessment in retrocervical endometriosis.Materials and methods: Seventy two females were assessed laparoscopically due to a gynecology disorder or infertility. Based on intraoperational data and results of pathomorphological assessments, two groups were formed: group 1 (control group, n = 26 comprised patients in reproductive age who had been admitted for elective surgery due to a gynecological disorder. Group 2 (main group, n = 46 included patients with various types of endometriosis. Patients from group 2 were divided into 3 subgroups: 2а (n = 17 – with superficial forms of external genital endometriosis; 2b (n = 18 – with endometrioid cysts; 2c (n = 11 – with deep infiltrative types of endometriosis.Results: Patients with superficial external genital endometriosis were characterized by positive symptom of “folding” (“freezing” of posterior uterine surface and of the walls of adjacent intestine. In endometriosis of posterior surface of cervix uteri, the diagnosis made by an ultrasound assessmentin 100% matched the diagnosis set during surgery, whereas if sacrouterine ligaments were involved, the diagnostic match was only 3%. In the group of patients with endometrioid cysts, in most of cases the cysts had specific ultrasound signs; coincidence of an ultrasound and a morphological diagnosis was seen in 98% of cases. Most cases of deep infiltrative endometriosis showed involvement of sacrouterine ligaments (72% and of parametrium (81%. There was a positive folding sign and a “Indian headdress

  4. Diagnostic and prognostic value of serum nitric oxide, tumor necrosis factor-alpha, basic fibroblast growth factor and copper as angiogenic markers in premenopausal breast cancer patients: a case-control study.

    Science.gov (United States)

    Hewala, T I; Abd El-Moneim, N A; Ebied, S Abd El-Moneim; Sheta, M I; Soliman, K; Abu-Elenean, A

    2010-01-01

    Many studies demonstrate that increased microvessel density (MVD) surrounding primary tumour is associated with decreased overall survival in patients with breast cancer. This study compares the diagnostic and prognostic values of the angiogenic serum factors nitric oxide (NO), tumour necrosis factor-alpha (TNFalpha), basic fibroblast growth factor (bFGF) and copper with those of serum CA15-3 as the standard tumour marker in breast cancer patients. Microvessel density was estimated in CD31-immunostained sections from breast cancer patients. Before surgery, NO, TNFalpha, bFGF, copper and CA 15-3 were measured in serum samples from 30 premenopausal breast cancer patients in comparison with 15 healthy controls. The diagnostic values of the assayed parameters were compared using receiver operating characteristic (ROC) curve analysis. Univariate survival analysis of patients was assessed using the Kaplan-Meier method. Breast cancer tissues showed higher MVD than did normal breast tissues adjacent to the tumour (P = 0.008). Before surgery, tumour MVD correlated significantly with serum NO, TNFalpha, bFGF and copper (r = 0.458, P = .011; r = 0.379, P = .039; r = 0.513, P = .004 and r = 0.613, P = 0.000, respectively). Serum NO, TNFalpha, bFGF, copper and CA 15-3 levels in patients were significantly elevated compared with controls (P = 0.011, P = 0.004, P = 0.039, P = 0.000 and P = 0.001, respectively). Kaplan-Meier analysis revealed that patients with elevated serum TNFalpha, CA 15-3 and copper (P = 0.035, P = 0.040, P = 0.0339, respectively) had an overall survival significantly shorter than those who had lower levels of these parameters. These data suggest that serum TNFalpha, CA 15-3 and copper are useful predictive markers for overall survival in premenopausal breast cancer patients.

  5. Portable Diagnostics and Rapid Germination

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Zachary Spencer [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-12-01

    In the Bioenergy and Defense Department of Sandia National Laboratories, characterization of the BaDx (Bacillus anthracis diagnostic cartridge) was performed and rapid germination chemistry was investigated. BaDx was tested with complex sample matrixes inoculated with Bacillus anthracis, and the trials proved that BaDx will detect Bacillus anthracis in a variety of the medium, such as dirt, serum, blood, milk, and horse fluids. The dimensions of the device were altered to accommodate an E. coli or Listeria lateral flow immunoassay, and using a laser printer, BaDx devices were manufactured to identify E. coli and Listeria. Initial testing with E. coli versions of BaDx indicate that the device will be viable as a portable diagnostic cartridge. The device would be more effective with faster bacteria germination; hence studies were performed the use of rapid germination chemistry. Trials with calcium dipicolinic acid displayed increased cell germination, as shown by control studies using a microplate reader. Upon lyophilization the rapid germination chemistry failed to change growth patterns, indicating that the calcium dipicolinic acid was not solubilized under the conditions tested. Although incompatible with the portable diagnostic device, the experiments proved that the rapid germination chemistry was effective in increasing cell germination.

  6. National NIF Diagnostic Program Interim Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Warner, B

    2002-04-25

    , cost, and schedule. The NIF Director controls the NNDP Interim Management Plan. A Draft Program Execution Plan (PEP) for the National NIF Diagnostics Program has been also been prepared (NIF-0072083, Oct 2001, attached as Attachment 1) that describes the NNDP technical, cost, and schedule baselines, the method by which the NNDP will fund and monitor the work to be done by the participating laboratories; the process for controlling changes; and the associated reporting and review process. This plan is expected to be approved by the relevant stakeholders at the appropriate time; however, since October 2001, the NNDP has been operating according to the processes laid out in the draft PEP. Below is a summary of the most important aspects of the NNDP that are being applied during this interim period before approval of the full PEP.

  7. Review of pathogenesis and diagnostic methods of immediate relevance for epidemiology and control of Salmonella Dublin in cattle

    DEFF Research Database (Denmark)

    Nielsen, Liza Rosenbaum

    2013-01-01

    and diagnosis of immediate relevance for epidemiology and control of S. Dublin at animal and herd level. Relatively few in vivo studies on S. Dublin pathogenesis in cattle included more than a few animals and often showed varying result. It makes it difficult to draw conclusions about mechanisms that affect...... dissemination in cattle and that might be targets for control methods directed towards improving resistance against the bacteria, e.g. new vaccines. It is recommended to perform larger studies to elucidate dose-response relationships and age- and genetic effects of immunity. Furthermore, it is recommended...... to attempt to develop faster and more sensitive methods for detection of S. Dublin for diagnosis of infectious animals....

  8. An In-situ materials analysis particle probe (MAPP) diagnostic to study particle density control and hydrogenic fuel retention in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    Allain, Jean-Paul [Purdue Univ., West Lafayette, IN (United States)

    2014-09-05

    A new materials analysis particle probe (MAPP) was designed, constructed and tested to develop understanding of particle control and hydrogenic fuel retention in lithium-based plasma-facing surfaces in NSTX. The novel feature of MAPP is an in-situ tool to probe the divertor NSTX floor during LLD and lithium-coating shots with subsequent transport to a post-exposure in-vacuo surface analysis chamber to measure D retention. In addition, the implications of a lithiated graphite-dominated plasma-surface environment in NSTX on LLD performance, operation and ultimately hydrogenic pumping and particle control capability are investigated in this proposal. MAPP will be an invaluable tool for erosion/redeposition simulation code validation.

  9. Methodology, models and algorithms in thermographic diagnostics

    CERN Document Server

    Živčák, Jozef; Madarász, Ladislav; Rudas, Imre J

    2013-01-01

    This book presents  the methodology and techniques of  thermographic applications with focus primarily on medical thermography implemented for parametrizing the diagnostics of the human body. The first part of the book describes the basics of infrared thermography, the possibilities of thermographic diagnostics and the physical nature of thermography. The second half includes tools of intelligent engineering applied for the solving of selected applications and projects. Thermographic diagnostics was applied to problematics of paraplegia and tetraplegia and carpal tunnel syndrome (CTS). The results of the research activities were created with the cooperation of the four projects within the Ministry of Education, Science, Research and Sport of the Slovak Republic entitled Digital control of complex systems with two degrees of freedom, Progressive methods of education in the area of control and modeling of complex object oriented systems on aircraft turbocompressor engines, Center for research of control of te...

  10. National NIF Diagnostic Program Fiscal Year 2002 Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    MacGowan, B

    2002-04-01

    Since October 2001 the development of the facility diagnostics for NIF has been funded by the NIF Director through the National NIF Diagnostic Program (NNDP). The current emphasis of the NNDP is on diagnostics for the early NIF quad scheduled to be available for experiment commissioning in FY03. During the past six months the NNDP has set in place processes for funding diagnostics, developing requirements for diagnostics, design reviews and monthly status reporting. Those processes are described in an interim management plan for diagnostics (''National NIF Diagnostic Program Interim Plan'', NIF-0081315, April 2002) and a draft Program Execution Plan (''Program Execution Plan for the National NlF Diagnostic Program'', NIF-0072083, October 2001) and documents cited therein. Work has been funded at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Naval Research Laboratory (NRL), Sandia National Laboratories (SNL), Bechtel Nevada at Los Alamos and Santa Barbara. There are no major technical risks with the early diagnostics. The main concerns relate to integration of the diagnostics into the facility, all such issues are being worked. This report is organized to show the schedule and budget status and a summary of Change Control Board actions for the past six months. The following sections then provide short descriptions of the status of each diagnostic. Where design reviews or requirements documents are cited, the documents are available on the Diagnostics file server or on request.

  11. Monitoring endemic livestock diseases using laboratory diagnostic data: A simulation study to evaluate the performance of univariate process monitoring control algorithms.

    Science.gov (United States)

    Lopes Antunes, Ana Carolina; Dórea, Fernanda; Halasa, Tariq; Toft, Nils

    2016-05-01

    Surveillance systems are critical for accurate, timely monitoring and effective disease control. In this study, we investigated the performance of univariate process monitoring control algorithms in detecting changes in seroprevalence for endemic diseases. We also assessed the effect of sample size (number of sentinel herds tested in the surveillance system) on the performance of the algorithms. Three univariate process monitoring control algorithms were compared: Shewart p Chart(1) (PSHEW), Cumulative Sum(2) (CUSUM) and Exponentially Weighted Moving Average(3) (EWMA). Increases in seroprevalence were simulated from 0.10 to 0.15 and 0.20 over 4, 8, 24, 52 and 104 weeks. Each epidemic scenario was run with 2000 iterations. The cumulative sensitivity(4) (CumSe) and timeliness were used to evaluate the algorithms' performance with a 1% false alarm rate. Using these performance evaluation criteria, it was possible to assess the accuracy and timeliness of the surveillance system working in real-time. The results showed that EWMA and PSHEW had higher CumSe (when compared with the CUSUM) from week 1 until the end of the period for all simulated scenarios. Changes in seroprevalence from 0.10 to 0.20 were more easily detected (higher CumSe) than changes from 0.10 to 0.15 for all three algorithms. Similar results were found with EWMA and PSHEW, based on the median time to detection. Changes in the seroprevalence were detected later with CUSUM, compared to EWMA and PSHEW for the different scenarios. Increasing the sample size 10 fold halved the time to detection (CumSe=1), whereas increasing the sample size 100 fold reduced the time to detection by a factor of 6. This study investigated the performance of three univariate process monitoring control algorithms in monitoring endemic diseases. It was shown that automated systems based on these detection methods identified changes in seroprevalence at different times. Increasing the number of tested herds would lead to faster

  12. Development of Companion Diagnostics.

    Science.gov (United States)

    Mankoff, David A; Edmonds, Christine E; Farwell, Michael D; Pryma, Daniel A

    2016-01-01

    The goal of individualized and targeted treatment and precision medicine requires the assessment of potential therapeutic targets to direct treatment selection. The biomarkers used to direct precision medicine, often termed companion diagnostics, for highly targeted drugs have thus far been almost entirely based on in vitro assay of biopsy material. Molecular imaging companion diagnostics offer a number of features complementary to those from in vitro assay, including the ability to measure the heterogeneity of each patient's cancer across the entire disease burden and to measure early changes in response to treatment. We discuss the use of molecular imaging methods as companion diagnostics for cancer therapy with the goal of predicting response to targeted therapy and measuring early (pharmacodynamic) response as an indication of whether the treatment has "hit" the target. We also discuss considerations for probe development for molecular imaging companion diagnostics, including both small-molecule probes and larger molecules such as labeled antibodies and related constructs. We then describe two examples where both predictive and pharmacodynamic molecular imaging markers have been tested in humans: endocrine therapy for breast cancer and human epidermal growth factor receptor type 2-targeted therapy. The review closes with a summary of the items needed to move molecular imaging companion diagnostics from early studies into multicenter trials and into the clinic.

  13. Pitfalls in diagnostic radiology

    Energy Technology Data Exchange (ETDEWEB)

    Peh, Wilfred C.G. (ed.) [Khoo Teck Puat Hospital (Singapore). Dept. of Diagnostic Radiology

    2015-04-01

    Only textbook to focus primarily on the topic of pitfalls in diagnostic radiology. Highlights the pitfalls in a comprehensive and systematic manner. Written by experts in different imaging modalities and subspecialties from reputable centers across the world. The practice of diagnostic radiology has become increasingly complex, with the use of numerous imaging modalities and division into many subspecialty areas. It is becoming ever more difficult for subspecialist radiologists, general radiologists, and residents to keep up with the advances that are occurring year on year, and this is particularly true for less familiar topics. Failure to appreciate imaging pitfalls often leads to diagnostic error and misinterpretation, and potential medicolegal problems. Diagnostic errors may be due to various factors such as inadequate imaging technique, imaging artifacts, failure to recognize normal structures or variants, lack of correlation with clinical and other imaging findings, and poor training or inexperience. Many, if not most, of these factors are potentially recognizable, preventable, or correctable. This textbook, written by experts from reputable centers across the world, systematically and comprehensively highlights the pitfalls that may occur in diagnostic radiology. Both pitfalls specific to different modalities and techniques and those specific to particular organ systems are described with the help of numerous high-quality illustrations. Recognition of these pitfalls is crucial in helping the practicing radiologist to achieve a more accurate diagnosis.

  14. MJO Simulation Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Waliser, D; Sperber, K; Hendon, H; Kim, D; Maloney, E; Wheeler, M; Weickmann, K; Zhang, C; Donner, L; Gottschalck, J; Higgins, W; Kang, I; Legler, D; Moncrieff, M; Schubert, S; Stern, W; Vitart, F; Wang, B; Wang, W; Woolnough, S

    2008-06-02

    The Madden-Julian Oscillation (MJO) interacts with, and influences, a wide range of weather and climate phenomena (e.g., monsoons, ENSO, tropical storms, mid-latitude weather), and represents an important, and as yet unexploited, source of predictability at the subseasonal time scale. Despite the important role of the MJO in our climate and weather systems, current global circulation models (GCMs) exhibit considerable shortcomings in representing this phenomenon. These shortcomings have been documented in a number of multi-model comparison studies over the last decade. However, diagnosis of model performance has been challenging, and model progress has been difficult to track, due to the lack of a coherent and standardized set of MJO diagnostics. One of the chief objectives of the US CLIVAR MJO Working Group is the development of observation-based diagnostics for objectively evaluating global model simulations of the MJO in a consistent framework. Motivation for this activity is reviewed, and the intent and justification for a set of diagnostics is provided, along with specification for their calculation, and illustrations of their application. The diagnostics range from relatively simple analyses of variance and correlation, to more sophisticated space-time spectral and empirical orthogonal function analyses. These diagnostic techniques are used to detect MJO signals, to construct composite life-cycles, to identify associations of MJO activity with the mean state, and to describe interannual variability of the MJO.

  15. Amazonian malaria: asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies.

    Science.gov (United States)

    da Silva-Nunes, Mônica; Moreno, Marta; Conn, Jan E; Gamboa, Dionicia; Abeles, Shira; Vinetz, Joseph M; Ferreira, Marcelo U

    2012-03-01

    Across the Americas and the Caribbean, nearly 561,000 slide-confirmed malaria infections were reported officially in 2008. The nine Amazonian countries accounted for 89% of these infections; Brazil and Peru alone contributed 56% and 7% of them, respectively. Local populations of the relatively neglected parasite Plasmodium vivax, which currently accounts for 77% of the regional malaria burden, are extremely diverse genetically and geographically structured. At a time when malaria elimination is placed on the public health agenda of several endemic countries, it remains unclear why malaria proved so difficult to control in areas of relatively low levels of transmission such as the Amazon Basin. We hypothesize that asymptomatic parasite carriage and massive environmental changes that affect vector abundance and behavior are major contributors to malaria transmission in epidemiologically diverse areas across the Amazon Basin. Here we review available data supporting this hypothesis and discuss their implications for current and future malaria intervention policies in the region. Given that locally generated scientific evidence is urgently required to support malaria control interventions in Amazonia, we briefly describe the aims of our current field-oriented malaria research in rural villages and gold-mining enclaves in Peru and a recently opened agricultural settlement in Brazil.

  16. Operational control and diagnostics of the equipment by the parameters of the electric drive power supply by the example of deep well pump units

    Science.gov (United States)

    Shishlyannikov, D. I.; Vasilyeva, M. A.

    2017-02-01

    Currently, the vast majority of Russian oil wells use oil well pumping units (OPU), equipped with a mechanical drive - a balancing pumping unit. The significant lifetime of balancing pumping units used in oil fields of Russia amounts to full or close to full resource generation and to a high accident rate of the mechanical drive rod of OPU. Reduced material costs for operation and maintenance of OPU may be provided by the rejection of the system of preventive maintenance and service during the transition to the actual technical condition. The article analyzes the statistics of the most frequent crash balancing pumping units of OPU and their causes. The prospect of applying the method of instrument control parameters is proved, and the technical condition of the OPU is assessed based on the analysis of the magnitude and the nature of changes in load drive motors, determined by the recording of the instantaneous values of power consumption. The authors consider the construction and operation of the programmable controller ‘AKD-SK’ manufactured by JSC R&D company ‘ROS’ (Perm). Fundamentals of vattmetrogramm analysis of OPU drive motors are stated, and the character of displaying key defects of submersible pumps and balanced beam unit is described.

  17. ORION laser target diagnostics.

    Science.gov (United States)

    Bentley, C D; Edwards, R D; Andrew, J E; James, S F; Gardner, M D; Comley, A J; Vaughan, K; Horsfield, C J; Rubery, M S; Rothman, S D; Daykin, S; Masoero, S J; Palmer, J B; Meadowcroft, A L; Williams, B M; Gumbrell, E T; Fyrth, J D; Brown, C R D; Hill, M P; Oades, K; Wright, M J; Hood, B A; Kemshall, P

    2012-10-01

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  18. ORION laser target diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

    2012-10-15

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  19. [Cytology in uropathological diagnostics].

    Science.gov (United States)

    Gaisa, N T; Lindemann-Docter, K

    2015-11-01

    Cytology in uropathological diagnostics is mainly performed for oncological purposes. The assessment of malignancy by urothelial cell morphology is therefore decisive; however, cytology is only sensitive enough to detect high-grade tumor cells and the different low-grade tumors cannot be reliably diagnosed. Thus, the four-tier classification system of cytological findings (i.e. negative, atypical cells but significance uncertain, suspicious and positive) refers to high-grade tumor cells only. Furthermore, for valid cytological diagnostics not only the cytological specimen but also clinical information on cystoscopy findings and, if applicable, a biopsy should be evaluated together. In difficult differential diagnostic settings, e.g. differentiation between reactive versus neoplastic atypia or difficult to access lesions in the upper urinary tract, additional fluorescence in situ hybridization of cytological preparations might be helpful. At the moment there are no indications for further immunocytology or additional biomarker tests.

  20. Diagnostic hematology of reptiles.

    Science.gov (United States)

    Stacy, Nicole I; Alleman, A Rick; Sayler, Katherine A

    2011-03-01

    The hematologic evaluation of reptiles is an indispensable diagnostic tool in exotic veterinary practice. The diversity of reptile species, their characteristic physiologic features, and effects of intrinsic and extrinsic factors present unique challenges for accurate interpretation of the hemogram. Combining the clinical presentation with hematologic findings provides valuable information in the diagnosis and monitoring of disease and helps guide the clinician toward therapy and further diagnostic testing. This article outlines the normal and pathologic morphology of blood cells of reptile species. The specific comparative aspects of reptiles are emphasized, and structural and functional abnormalities in the reptilian hemogram are described.

  1. Beam Instrumentation and Diagnostics

    CERN Document Server

    Strehl, Peter

    2006-01-01

    This treatise covers all aspects of the design and the daily operations of a beam diagnostic system for a large particle accelerator. A very interdisciplinary field, it involves contributions from physicists, electrical and mechanical engineers and computer experts alike so as to satisfy the ever-increasing demands for beam parameter variability for a vast range of operation modi and particles. The author draws upon 40 years of research and work, most of them spent as the head of the beam diagnostics group at GSI. He has illustrated the more theoretical aspects with many real-life examples that will provide beam instrumentation designers with ideas and tools for their work.

  2. [Molecular diagnostics and imaging].

    Science.gov (United States)

    Fink, Christian; Fisseler-Eckhoff, Annette; Huss, Ralf; Nestle, Ursula

    2009-01-01

    Molecular diagnostic methods and biological imaging techniques can make a major contribution to tailoring patients' treatment needs with regard to medical, ethical and pharmaco-economic aspects. Modern diagnostic methods are already being used to help identify different sub-groups of patients with thoracic tumours who are most likely to benefit significantly from a particular type of treatment. This contribution looks at the most recent developments that have been made in the field of thoracic tumour diagnosis and analyses the pros and cons of new molecular and other imaging techniques in day-to-day clinical practice.

  3. Multidisciplinary molecular diagnostics: the 9th European meeting on molecular diagnostics.

    Science.gov (United States)

    Loonen, Anne J M; Schuurman, Rob; van den Brule, Adriaan J C

    2016-01-01

    This report presents a summary of the 9th European Meeting on Molecular Diagnostics held in Noordwijk, The Netherlands, 14-16 October 2015. This 3-day conference covered many relevant topics in the field of molecular diagnostics in humans, including infectious disease, oncology, outbreak management, population-based cancer screening, standardization and quality control, chronic diseases and pharmacogenetics. Beyond these different areas, shared values are new technologies and novel technical and clinical applications. Approximately 450 participants, the majority coming from European countries, attended the meeting. Besides high quality scientific presentations, more than 35 diagnostic companies presented their latest innovations, altogether in an informal and inspiring scientific ambience.

  4. Diagnostic comparison of Centers for Disease Control and Prevention and International Obesity Task Force criteria for obesity classification in South African children

    Directory of Open Access Journals (Sweden)

    Kankane V. Moselakgomo

    2017-01-01

    Full Text Available Background: This study was designed to estimate overweight and obesity in school children by using contrasting definitions recommended by the Centers for Disease Control and Prevention (CDC and the International Obesity Task Force (IOTF.Method: The sample size consisted of 1361 learners (n = 678 boys; n = 683 girls aged 9–13 years who were randomly selected from Mpumalanga and Limpopo provinces of South Africa. A cross-sectional and descriptive design was used to measure the children’s anthropometric characteristics. Based on height and weight measurements, the children’s body mass index (BMI was calculated and used to classify them as underweight, overweight and obese. Percentage body fat was calculated from the sum of two skinfolds (i.e. triceps and subscapular. Age-specific BMI, percentage body fat and sum of skinfolds were examined for the boys and girls.Results: A higher prevalence of overweight and obesity was found in boys and girls when the CDC BMI categories were used. In contrast, the IOTF BMI classifications indicated a strong prevalence of underweight among the children.Conclusion: In contrast to the IOTF index that yielded a greater occurrence of underweight among South African children, the CDC criteria indicated a higher prevalence of obesity and overweight among the same children. Future large-scale surveillance studies are needed to determine the appropriateness of different definitions in order to establish a more reliable indicator for estimating overweight and obesity in South African children.

  5. New tuberculosis diagnostics and rollout

    Directory of Open Access Journals (Sweden)

    Ruth McNerney

    2015-03-01

    Full Text Available Early detection and effective treatment are crucial for tuberculosis control, but global case detection rates remain low. The diagnosis of paediatric and extrapulmonary disease is problematic and there are, as yet, no rapid screening tests to assist active case finding in the community. Progress has been made in clinic-based detection tools with the introduction of Xpert MTB/RIF, a nucleic acid amplification test that combines sample processing and analysis in a single instrument to provide a diagnostic result and detection of resistance to rifampicin in under 2 h. Enthusiasm for Xpert MTB/RIF has been high and global rollout has been facilitated by donor agencies. However, concerns remain about access and sustainability due to the high cost and infrastructure requirements. Although more sensitive than smear microscopy, early studies suggest the impact of the new test on case detection rates and patient survival has been limited. Alternative technologies are being developed, including non-sputum-based tests to assist the detection of extrapulmonary disease. Evaluation studies are needed to provide evidence of the impact of the new technologies on patient outcomes. This will enable appropriate placement of new diagnostic products in the healthcare system to support the control and eventual eradication of tuberculosis disease.

  6. Diagnostics for FIRE: A status report

    Science.gov (United States)

    Young, Kenneth M.

    2003-03-01

    The mission for the proposed fusion ignition research experiment (FIRE) device is to "attain, explore, understand and optimize fusion-dominated plasmas." Operation at Q⩾5, for 20 s with a fusion power output of ˜150 MW is the major goal. Attaining this mission sets demands for plasma measurement which are at least as comprehensive as on present tokamaks, with the additional capabilities needed for control of the plasma and for understanding the effects of the alpha-particles. Because of the planned operation in advanced tokamak scenarios, with steep transport barriers, the diagnostic instrumentation must be able to provide fine spatial and temporal resolution. It must also be able to withstand the impact of the intense neutron and gamma irradiation. There are practical engineering issues of minimizing radiation streaming while providing essential diagnostic access to the plasma. Many components will operate close to the first wall, e.g., ceramics and mineral insulated cable for magnetic diagnostics and mirrors for optical diagnostics; these components must be selected and mounted so that they will operate and survive in fluxes which require special material selection. The measurement requirements have been assessed so that the diagnostics for the FIRE device can be defined. Clearly, a better set of diagnostics of alpha-particles than that available for TFTR is essential, since the alpha-particles provide the dominant sources of heating and of instability-drive in the plasma.

  7. A molecular diagnostic tool for the preliminary assessment of host-parasitoid associations in biological control programmes for a new invasive pest.

    Science.gov (United States)

    Gariepy, T D; Haye, T; Zhang, J

    2014-08-01

    Evaluation of host-parasitoid associations can be tenuous using conventional methods. Molecular techniques are well placed to identify trophic links and resolve host-parasitoid associations. Establishment of the highly invasive brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), outside Asia has prompted interest in the use of egg parasitoids (Hymenoptera: Scelionidae) as biological control agents. However, little is known regarding their host ranges. To address this, a DNA barcoding approach was taken wherein general PCR primers for Scelionidae and Pentatomidae were developed to amplify and sequence >500-bp products within the DNA barcoding region of the cytochrome oxidase I (COI) gene that would permit the identification of key players in this association. Amplification of DNA from Pentatomidae and Scelionidae was consistent across a broad range of taxa within these families, and permitted the detection of Scelionidae eggs within H. halys 1 h following oviposition. In laboratory assays, amplification and sequencing of DNA from empty, parasitized eggs was successful for both host (100% success) and parasitoid (50% success). When applied to field-collected, empty egg masses, the primers permitted host identification in 50-100% of the eggs analysed, and yielded species-level identifications. Parasitoid identification success ranged from 33 to 67% among field-collected eggs, with genus-level identification for most specimens. The inability to obtain species-level identities for these individuals is due to the lack of coverage of this taxonomic group in public DNA sequence databases; this situation is likely to improve as more species are sequenced and recorded in these databases. These primers were able to detect and identify both pentatomid host and scelionid parasitoid in a hyperparasitized egg mass, thereby clarifying trophic links otherwise unresolved by conventional methodology.

  8. Diagnostic and interventional radiology

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, Thomas J. [Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt am Main (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Reith, Wolfgang [Universitaetsklinikum des Saarlandes, Homburg/Saar (Germany). Klinik fuer Diagnostische und Interventionelle Neuroradiologie; Rummeny, Ernst J. (ed.) [Technische Univ. Muenchen Klinikum rechts der Isar, Muenchen (Germany). Inst. fuer Radiologie

    2016-08-01

    This exceptional book covers all aspects of diagnostic and interventional radiology within one volume, at a level appropriate for the specialist. From the basics through diagnosis to intervention: the reader will find a complete overview of all areas of radiology. The clear, uniform structure, with chapters organized according to organ system, facilitates the rapid retrieval of information. Features include: Presentation of the normal radiological anatomy Classification of the different imaging procedures according to their diagnostic relevance Imaging diagnosis with many reference images Precise description of the interventional options The inclusion of many instructive aids will be of particular value to novices in decision making: Important take home messages and summaries of key radiological findings smooth the path through the jungle of facts Numerous tables on differential diagnosis and typical findings in the most common diseases offer a rapid overview and orientation Diagnostic flow charts outline the sequence of diagnostic evaluation All standard procedures within the field of interventional radiology are presented in a clinically relevant and readily understandable way, with an abundance of illustrations. This is a textbook, atlas, and reference in one: with more than 2500 images for comparison with the reader's own findings. This comprehensive and totally up-to-date book provides a superb overview of everything that the radiology specialist of today needs to know.

  9. Beamlet focal plane diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Caird, J.A.; Nielsen, N.D.; Patton, H.G.; Seppala, L.G.; Thompson, C.E.; Wegner, P.J.

    1996-12-01

    This paper describes the major optical and mechanical design features of the Beamlet Focal Plane Diagnostic system as well as measurements of the system performance, and typical data obtained to date. We also discuss the NIF requirements on the focal spot that we are interested in measuring, and some of our plans for future work using this system.

  10. A portable lab-on-a-chip instrument based on MCE with dual top-bottom capacitive coupled contactless conductivity detector in replaceable cell cartridge.

    Science.gov (United States)

    Ansari, Kambiz; Ying, Jasmine Yuen Shu; Hauser, Peter C; de Rooij, Nico F; Rodriguez, Isabel

    2013-05-01

    A new design for a compact portable lab-on-a-chip instrument based on MCE and dual capacitively coupled contactless conductivity detection (dC(4) D) is described. The instrument is battery powered with total dimension of 14 × 25 × 8 cm(3) (w × l × h), and weighs 1.2 kg. The device consists of a front electrophoresis compartment which has the chip holder and the chip, the associated high-voltage electrodes for electrophoresis injection and separation and the detector. The detection cell is integrated into the device housing with an exchangeable plug-and-play cartridge format. The design of the dC(4) D cell has been optimized for maximum performance. The cartridge includes the top-bottom excitation and pick up electrodes incorporated into the cell and connected to push-pull self-latching pins that are insulated with plastic. The metal frame of the cartridge is grounded completely to eliminate electronic interferences. The cartridge is designed to clamp a thin fluidic chip at the detection point. The cartridges are replaceable whereby different cartridges have different detection electrode configurations to employ according to the sensitivity or resolution needed in the specific analytical application. The second compartment consists of all the electronics, data acquisition card, high-voltage modules of up to ±5 kV both polarity, and batteries for 10 h of operation. The improved detector performance is illustrated by the electrophoresis analysis of six cations (NH4 (+) , K(+) , Ca(2+) , Na(+) , Mg(2+) , Li(+) ) with a detection limit of approximately 5 μM and the analysis of the anions (Br(-) , Cl(-) , NO2 (-) , NO3 (-) , SO4 (2-) , F(-) ) with a detection limit of about 3 μM. Analytical capabilities of the instrument for food and medical applications were evaluated by simultaneous detection of organic and inorganic acids in fruit juice and inorganic cations and anions in rabbit blood samples and human urine samples are also demonstrated.

  11. 40 CFR 86.1806-04 - On-board diagnostics.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false On-board diagnostics. 86.1806-04..., and Complete Otto-Cycle Heavy-Duty Vehicles § 86.1806-04 On-board diagnostics. This § 86.1806-04... alternative to SAE J1850. (iii) ISO 15765-4.3:2001 “Road Vehicles-Diagnostics on Controller Area Network...

  12. Multi-method automated diagnostics of rotating machines

    Science.gov (United States)

    Kostyukov, A. V.; Boychenko, S. N.; Shchelkanov, A. V.; Burda, E. A.

    2017-08-01

    The automated machinery diagnostics and monitoring systems utilized within the petrochemical plants are an integral part of the measures taken to ensure safety and, as a consequence, the efficiency of these industrial facilities. Such systems are often limited in their functionality due to the specifics of the diagnostic techniques adopted. As the diagnostic techniques applied in each system are limited, and machinery defects can have different physical nature, it becomes necessary to combine several diagnostics and monitoring systems to control various machinery components. Such an approach is inconvenient, since it requires additional measures to bring the diagnostic results in a single view of the technical condition of production assets. In this case, we mean by a production facility a bonded complex of a process unit, a drive, a power source and lines. A failure of any of these components will cause an outage of the production asset, which is unacceptable. The purpose of the study is to test a combined use of vibration diagnostics and partial discharge techniques within the diagnostic systems of enterprises for automated control of the technical condition of rotating machinery during maintenance and at production facilities. The described solutions allow you to control the condition of mechanical and electrical components of rotating machines. It is shown that the functionality of the diagnostics systems can be expanded with minimal changes in technological chains of repair and operation of rotating machinery. Automation of such systems reduces the influence of the human factor on the quality of repair and diagnostics of the machinery.

  13. Multicentre comparison of a diagnostic assay

    DEFF Research Database (Denmark)

    Waters, Patrick; Reindl, Markus; Saiz, Albert;

    2016-01-01

    ) assays in neuromyelitis optica spectrum disorders (NMOSD). METHODS: Coded samples from patients with neuromyelitis optica (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 assays including live (n=3) or fixed cell-based assays (n=10), flow cytometry (n=4...

  14. Brucellosis: Epizootiologic and diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Radojičić Sonja

    2005-01-01

    Full Text Available Although it has been known as a separate etiological entity for almost 150 years, brucellosis is, on a global scale, one of the most frequent diseases that is transferred from animals to humans. It is present as an endemic disease in almost all countries of the Mediterranean Sea, which indicates that a large number of aspects in connection with the control and epizootiology of this disease still remain unexplained. Three of the six types of brucella have been officially confirmed in our country as well. They are Brucella melitensis biotip 3, Brucella suis biotip 2 and Brucella canis. Brucellosis is endemically present in Kosovo and Metohija province and in southern Serbia proper; over the past few years, the spread of brucellosis in sheep and goats as primary hosts for B. melitensis to new territories, mostly in Vojvodina province, has shown that risk analysis is one of the main factors in selecting and implementing control programmes. A correctly selected set of diagnostic tests yields reliable data in most cases, but interpretations of results are prone to result in subjective assessments as well. A special problem in the serological diagnosis of brucellosis is the cross reactivity of brucellas and some other bacteria, often a weak immunological response of the animal, or that the type of brucella that causes the infection determines the sensitivity and specificity of the applied tests, most often screenings tests. Due to the big economic losses resulting from disease control and eradication, and the serious risk to human health, brucellosis still poses an epizootiological, and, in particular, a diagnostic challenge.

  15. Diagnostic evaluation of dysphagia.

    Science.gov (United States)

    Cook, Ian J

    2008-07-01

    Taking a careful history is vital for the evaluation of dysphagia. The history will yield the likely underlying pathophysiologic process and anatomic site of the problem in most patients, and is crucial for determining whether subsequently detected radiographic or endoscopic 'anomalies' are relevant or incidental. Although the symptoms of pharyngeal dysphagia can be multiple and varied, the typical features of neurogenic pharyngeal dysphagia are highly specific, and can accurately distinguish pharyngeal from esophageal disorders. The history will also dictate whether the next diagnostic procedure should be endoscopy, a barium swallow or esophageal manometry. In some difficult cases, all three diagnostic techniques may need to be performed to establish an accurate diagnosis. Stroke is the most common cause of pharyngeal dysphagia. A videoradiographic swallow study is vital in such cases to determine the extent and timing of aspiration and the severity and mechanics of dysfunction as a prelude to therapy.

  16. Nanobiosensors in diagnostics

    Directory of Open Access Journals (Sweden)

    Alejandro Chamorro-Garcia

    2016-11-01

    Full Text Available Medical diagnosis has been greatly improved thanks to the development of new techniques capable of performing very sensitive detection and quantifying certain parameters. These parameters can be correlated with the presence of specific molecules and their quantity. Unfortunately, these techniques are demanding, expensive, and often complicated. On the other side, progress in other fields of science and technology has contributed to the rapid growth of nanotechnology. Although being an emerging discipline, nanotechnology has raised huge interest and expectations. Most of the enthusiasm comes from new possibilities and properties of nanomaterials. Biosensors (simple, robust, sensitive, cost-effective combined with nanomaterials, also called nanobiosensors, are serving as bridge between advanced detection/diagnostics and daily/routine tests. Here we review some of the latest applications of nanobiosensors in diagnostics field.

  17. Gene Disease Diagnostic System

    Institute of Scientific and Technical Information of China (English)

    黄国亮; 张腾飞; 程京; 周玉祥; 刘诚迅; 金国藩; 邬敏贤; 严瑛白; 杨蓉

    2002-01-01

    Binary optics, where the optical element can be fabricated on a thin glass plate with micro-ion-etching film layer, has been widely applied in recent years. A novel optical scanning system for gene disease diagnostics described in this paper has four kinds of optical devices, including beam splitters, an array lens, an array filter and detection arrays. A software was developed to design the binary optics system using an iterative method. Two beam splitters were designed and fabricated, which can divide a beam into a 9×9 array or into a 13×13 array. The beam splitters have good diffraction efficiencies (>70%) and an even energy distribution. The gene disease diagnostic system is a portable biochip and binary optics technology. The binary optical devices in the non-confocal scanning system can raise the fluorescence detection sensitivity of the micro-array hybrid biochip.

  18. Patient dosimetry in diagnostic radiology

    Directory of Open Access Journals (Sweden)

    Ciraj-Bjelac Olivera F.

    2003-01-01

    Full Text Available The objective of this work is to assess patient organ doses, effective doses and entrance surface doses in conventional diagnostic radiology procedures for standard adult patient. The survey consists of measurements of doses delivered to 239 patients in nine types of X-ray examinations. Three types of data were collected: X-ray machine data, patient data, and output measurements. Entrance surface dose was assessed based on the survey data and subsequently, using conversion coefficients, the organ doses and effective doses were calculated. Values of the entrance surface dose and the effective dose were estimated to be 0.4 to 5.8 mGy and 0.03 to 3.00 mSv for different examinations. Derived doses were compared with recommended general diagnostic reference levels. The impact of examination parameters on dose values was discussed. Except for posterior-anterior chest examination, all estimated doses are lower than stated reference levels. Survey data are aimed at helping development of national quality control and radiation protection programmed for medical exposures.

  19. PROcess Based Diagnostics PROBE

    Science.gov (United States)

    Clune, T.; Schmidt, G.; Kuo, K.; Bauer, M.; Oloso, H.

    2013-01-01

    Many of the aspects of the climate system that are of the greatest interest (e.g., the sensitivity of the system to external forcings) are emergent properties that arise via the complex interplay between disparate processes. This is also true for climate models most diagnostics are not a function of an isolated portion of source code, but rather are affected by multiple components and procedures. Thus any model-observation mismatch is hard to attribute to any specific piece of code or imperfection in a specific model assumption. An alternative approach is to identify diagnostics that are more closely tied to specific processes -- implying that if a mismatch is found, it should be much easier to identify and address specific algorithmic choices that will improve the simulation. However, this approach requires looking at model output and observational data in a more sophisticated way than the more traditional production of monthly or annual mean quantities. The data must instead be filtered in time and space for examples of the specific process being targeted.We are developing a data analysis environment called PROcess-Based Explorer (PROBE) that seeks to enable efficient and systematic computation of process-based diagnostics on very large sets of data. In this environment, investigators can define arbitrarily complex filters and then seamlessly perform computations in parallel on the filtered output from their model. The same analysis can be performed on additional related data sets (e.g., reanalyses) thereby enabling routine comparisons between model and observational data. PROBE also incorporates workflow technology to automatically update computed diagnostics for subsequent executions of a model. In this presentation, we will discuss the design and current status of PROBE as well as share results from some preliminary use cases.

  20. Idiopathic chondrolysis - diagnostic difficulties

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, K.; Scougall, J.

    1984-07-01

    Four cases of idiopathic chondrolysis of the hip in three white girls and one Maori girl are reported. The authors stress the causes why a disease with characteristic clinical and radiographic appearances and normal biochemical findings presents diagnostic difficulties. It is suspected that idiopathic chondrolysis is a metabolic disorder of chondrocytes, triggered by environment circumstances in susceptible individuals. Idiopathic chondrolysis is probably one of the most common causes of coxarthrosis in women.

  1. STELLA Experiment - Microbunch Diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    He, P.; Liu, Y.; Cline, D. B.; Babzien, M.; Gallardo, J. C.; Kusche, K. P.; Pogorelsky, I. V.; Skaritka, J.; van Steenbergen, A.; Yakimenko, V.; Kimura, W. D.

    1998-07-01

    A microbunch diagnostic system is built at the Accelerator Test Facility (ATF) of Brookhaven National Laboratory for monitoring microbunches (10-fs bunch length) produced by the Inverse Free Electron Laser accelerator in Staged Electron Laser Acceleration experiment. It is similar to one already demonstrated at the ATF. With greatly improved beam optics conditions higher order harmonic coherent transition radiation will be measurable to determine the microbunch length and shape.

  2. Diagnostic complexities of eosinophilia.

    Science.gov (United States)

    Montgomery, Nathan D; Dunphy, Cherie H; Mooberry, Micah; Laramore, Andrew; Foster, Matthew C; Park, Steven I; Fedoriw, Yuri D

    2013-02-01

    The advent of molecular tools capable of subclassifying eosinophilia has changed the diagnostic and clinical approach to what was classically called hypereosinophilic syndrome. To review the etiologies of eosinophilia and to describe the current diagnostic approach to this abnormality. Literature review. Eosinophilia is a common, hematologic abnormality with diverse etiologies. The underlying causes can be broadly divided into reactive, clonal, and idiopathic. Classically, many cases of eosinophilia were grouped together into the umbrella category of hypereosinophilic syndrome, a clinical diagnosis of exclusion. In recent years, an improved mechanistic understanding of many eosinophilias has revolutionized the way these disorders are understood, diagnosed, and treated. As a result, specific diagnoses can now be assigned in many cases that were previously defined as hypereosinophilic syndrome. Most notably, chromosomal rearrangements, such as FIP1L1-PDGFRA fusions caused by internal deletions in chromosome 4, are now known to be associated with many chronic eosinophilic leukemias. When present, these specific molecular abnormalities predict response to directed therapies. Although an improved molecular understanding is revolutionizing the treatment of patients with rare causes of eosinophilia, it has also complicated the approach to evaluating and treating eosinophilia. Here, we review causes of eosinophilia and present a framework by which the practicing pathologist may approach this diagnostic dilemma. Finally, we consider recent cases as clinical examples of eosinophilia from a single institution, demonstrating the diversity of etiologies that must be considered.

  3. [Histopathological meniscus diagnostic].

    Science.gov (United States)

    Fisseler-Eckhoff, A; Müller, K-M

    2009-06-01

    Menisci fulfill many functions within the complex biomechanics of the knee joint. In the case of meniscus lesions, sparing arthroscopic resections and operative refixation are the treatments of choice. With regard to diagnostics, this means that in general terms, the histopathologic diagnostics are carried out on detached meniscus fragments of between 5 mm and 2 cm in size. An experienced pathologist's knowledge of physiologically possible cellular and fibrous histological meniscus damage, as opposed to nonphysiological change regarded as normal with respect to age, is essential during a diagnostic meniscus evaluation. The clinician expects clear statements from the pathologist regarding the severity of previous or secondary degenerative meniscus damage, the age and type of traumatic tears, and appraisal of the relationship between trauma and meniscus damage from an insurance point of view. Close cooperation between the clinician and the pathologist allows for fast and unambiguous correlation of anamnesis, the clinical picture, and morphological reporting so that cases involving insurance problems - which are numerous, often long-term, and often unsatisfactory - can be clarified quickly.

  4. Diagnostics for Developing Countries

    Directory of Open Access Journals (Sweden)

    Ruth McNerney

    2015-05-01

    Full Text Available Improving the availability of high quality diagnostic tests for infectious diseases is a global priority. Lack of access by people living in low income countries may deprive them of life saving treatment and reduces opportunities to prevent onward transmission and spread of the disease. Diagnostic laboratories are often poorly resourced in developing countries, and sparsely distributed. Improved access may be achieved by using tests that do not require laboratory support, including rapid tests for use at the point-of-care. Despite increased interest, few new in vitro diagnostic (IVD products reach the majority populations in low income countries. Barriers to uptake include cost and lack of robustness, with reduced test performances due to environmental pressures such as high ambient temperatures or dust. In addition to environmental factors test developers must consider the local epidemiology. Confounding conditions such as immunosuppression or variations in antigen presentation or genotype can affect test performance. Barriers to product development include access to finance to establish manufacturing capacity and cover the costs of market entry for new devices. Costs and delays may be inflated by current regulatory preregistration processes to ensure product safety and quality, and more harmonized approaches are needed.

  5. SNS Diagnostics Timing Integration

    CERN Document Server

    Long, Cary D; Murphy, Darryl J; Pogge, James; Purcell, John D; Sundaram, Madhan

    2005-01-01

    The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based running Windows XP Embedded for its OS and LabVIEW as its programming language. Coordinating timing among the various diagnostics instruments with the generation of the beam pulse is a challenging task that we have chosen to divide into three phases. First, timing was derived from VME based systems. In the second phase, described in this paper, timing pulses are generated by an in house designed PCI timing card installed in ten diagnostics PCs. Using fan-out modules, enough triggers were generated for all instruments. This paper describes how the Timing NAD (Network Attached Device) was rapidly developed using our NAD template, LabVIEW's PCI driver wizard, and LabVIEW Channel Access library. The NAD...

  6. Molecular diagnostics of periodontitis

    Directory of Open Access Journals (Sweden)

    Izabela Korona-Głowniak

    2017-01-01

    Full Text Available The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host’s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain reaction (PCR, real-time polymerase chain reaction (real-time PCR, 16S rRNA-encoding gene sequencing, checkerboard and reverse-capture checkerboard hybridization, microarrays, denaturing gradient gel electrophoresis (DGGE, temperature gradient gel electrophoresis (TGGE, as well as terminal restriction fragment length polymorphism (TRFLP and next generation sequencing (NGS. The advantages and drawbacks of each method in the examination of periopathogens are indicated. The techniques listed above allow fast detection of even small quantities of pathogen present in diagnostic material and prove particularly useful to detect microorganisms that are difficult or impossible to grow in a laboratory.

  7. ODX - diagnostic standard and development tools; ODX Diagnosestandard und Entwicklungswerkzeuge

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, A.; Kricke, C.; Meyer, J. [ETAS GmbH, Stuttgart (Germany)

    2005-09-01

    ODX, the new standard for the description of diagnostic protocols and data for electronic control units was released a year ago. After a brief review of the standard, ETAS introduces development tools for measuring, calibration, and diagnostic applications, with an emphasis on ECU calibration tasks. (orig.)

  8. IMPLEMENTATION OF TURNOUTS TECHNICAL DIAGNOSTICS SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. YU. Buryak

    2015-06-01

    Full Text Available Purpose. In the paper it is necessary to: 1 find out the causes of turnouts faults to determine diagnostic features failures; 2 consider the requirements structure, purpose components of turnouts, work and technology of their maintenance to determine the construction of the economic activities related to system to the turnout’s maintenance; 3 substantiate the possibility, necessity and prospects of automated diagnostics turnout’s implementation; 4 elaborate a prototype of an automated hardware and software system for the turnouts control parameters and perform diagnostics on them. Methodology. In the paper possible turnouts faults were presented and manifestations and influence on its work were shown. According to the current technology works the process analyze of turnouts’ maintenance was conducted, were defined the basic performed operations during the examination of appearance, parameters and check the repair or replacement of parts and assemblies. Based on the analysis of reasons of turnouts malfunctioning and their fixes were systematized types of damages and ways to deal with them, an information scheme of troubleshooting were created, opportunities and limits of automating the process of diagnostics were identified and compared with the existing method of turnouts maintenance. A diagnostics system block diagram was created, an algorithm of its work was developed and established main basic principles of operation. Software and hardware to determine the turnout’s state considering diagnostic performance of points in use were applied. Findings. During the experiment was created a method of automated turnout’s diagnostics with AC electric drives, managed centrally. The results of automated hardware and software system make it possible to control turnout’s parameters and perform diagnostics on them. Originality. Authors created the method of turnout’s state determination by current curve and its spectral composition in the

  9. Fusion neutron diagnostics on ITER tokamak

    Science.gov (United States)

    Bertalot, L.; Barnsley, R.; Direz, M. F.; Drevon, J. M.; Encheva, A.; Jakhar, S.; Kashchuk, Y.; Patel, K. M.; Arumugam, A. P.; Udintsev, V.; Walker, C.; Walsh, M.

    2012-04-01

    ITER is an experimental nuclear reactor, aiming to demonstrate the feasibility of nuclear fusion realization in order to use it as a new source of energy. ITER is a plasma device (tokamak type) which will be equipped with a set of plasma diagnostic tools to satisfy three key requirements: machine protection, plasma control and physics studies by measuring about 100 different parameters. ITER diagnostic equipment is integrated in several ports at upper, equatorial and divertor levels as well internally in many vacuum vessel locations. The Diagnostic Systems will be procured from ITER Members (Japan, Russia, India, United States, Japan, Korea and European Union) mainly with the supporting structures in the ports. The various diagnostics will be challenged by high nuclear radiation and electromagnetic fields as well by severe environmental conditions (ultra high vacuum, high thermal loads). Several neutron systems with different sensitivities are foreseen to measure ITER expected neutron emission from 1014 up to almost 1021 n/s. The measurement of total neutron emissivity is performed by means of Neutron Flux Monitors (NFM) installed in diagnostic ports and by Divertor Neutron Flux Monitors (DNFM) plus MicroFission Chambers (MFC) located inside the vacuum vessel. The neutron emission profile is measured with radial and vertical neutron cameras. Spectroscopy is accomplished with spectrometers looking particularly at 2.5 and 14 MeV neutron energy. Neutron Activation System (NAS), with irradiation ends inside the vacuum vessel, provide neutron yield data. A calibration strategy of the neutron diagnostics has been developed foreseeing in situ and cross calibration campaigns. An overview of ITER neutron diagnostic systems and of the associated challenging engineering and integration issues will be reported.

  10. AI-Based Diagnostic Shell

    Directory of Open Access Journals (Sweden)

    R. L. Verma

    1989-01-01

    Full Text Available This paper datails the design and implementation of an AI-based diagnostic shell. The shell has a user-interface which takes in the complaint and aids the user throughout the consultation. The 'expert knowledge' is acquired and encoded in the form of 'IF-THEN' rules, The control mechanism routes through the rules chaining first backwards to identify a fault and then forwards to confirm it.Explanation facilities have been provided to enable the user query the reason for any question asked, a facility to go back and re-answer any previous question, and a trace and explanation of the path of reasoning.This shell was developed and first used for the diagnosis of a digital exchange. It was then applied for the fault-finding of the moving target indicator used in the radar.

  11. BIOANALYTICAL STANDARDIZING FOR SEROLOGICAL DIAGNOSTIC MEDICAL DEVICES

    Directory of Open Access Journals (Sweden)

    A. Yu. Galkin

    2015-04-01

    Full Text Available In article we analyzed national and international regulations concerning the quality and safety of medical devices for in vitro diagnostics. We discussed the possibility of a partial application of the recommendations of the State Pharmacopoeia of Ukraine to this type of product. The main guiding regulatory documents establishing requirements for quality and safety tools for the serological diagnosis products are The technical regulation on medical devices for the diagnosis in vitro, DSTU ISO 13485 “Medical devices. Quality management system. Regulatory requirements”, and DSTU ISO/IEC 17025 “General requirements for the competence of testing and calibration laboratories”. Similar requirements of the State Pharmacopoeia of Ukraine which are used for drug standardization can not be directly applied to the medical devises for in vitro diagnostics due to a number of features, namely, the serological diagnosis products pre-designed to determine the unknown concentration of a particular analyte in a biological material, the diagnostic kits has to include the control samples (internal standard systems that need to be calibrated. It was determined following parameters of bioanalytical standardization and validation characterization for of qualitative (semi quantitative test-kits for serological diagnosis: precision (convergence, intralaboratory precision and reproducibility, diagnostic and analytical specificity, diagnostic sensitivity. It’s necessary to inspect additional parameters for quantitative test-kits such as accuracy (precision, linearity, analytical sensitivity and range.

  12. Invasive mycoses: diagnostic challenges.

    Science.gov (United States)

    Ostrosky-Zeichner, Luis

    2012-01-01

    Despite the availability of newer antifungal drugs, outcomes for patients with invasive fungal infections (IFIs) continue to be poor, in large part due to delayed diagnosis and initiation of appropriate antifungal therapy. Standard histopathologic diagnostic techniques are often untenable in at-risk patients, and culture-based diagnostics typically are too insensitive or nonspecific, or provide results after too long a delay for optimal IFI management. Newer surrogate markers of IFIs with improved sensitivity and specificity are needed to enable earlier diagnosis and, ideally, to provide prognostic information and/or permit therapeutic monitoring. Surrogate assays should also be accessible and easy to implement in the hospital. Several nonculture-based assays of newer surrogates are making their way into the medical setting or are currently under investigation. These new or up-and-coming surrogates include antigens/antibodies (mannan and antimannan antibodies) or fungal metabolites (d-arabinitol) for detection of invasive candidiasis, the Aspergillus cell wall component galactomannan used to detect invasive aspergillosis, or the fungal cell wall component and panfungal marker β-glucan. In addition, progress continues with use of polymerase chain reaction- or other nucleic acid- or molecular-based assays for diagnosis of either specific or generic IFIs, although the various methods must be better standardized before any of these approaches can be more fully implemented into the medical setting. Investigators are also beginning to explore the possibility of combining newer surrogate markers with each other or with more standard diagnostic approaches to improve sensitivity, specificity, and capacity for earlier diagnosis, at a time when fungal burden is still relatively low and more responsive to antifungal therapy.

  13. Diagnostic electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Dickersin, G.R.

    1988-01-01

    In this book the author presents a comprehensive reference text on diagnostic electron microscopy. Throughout the book he illustrates how ultrastructural identification can be helpful for the recognition of cell type and the identification of mechanisms of pathogenesis in various diseases. In addition to electron microscopy photographs, there are also numerous light microscopy photographs for comparison. This text presents the classification of neoplasms in the order and arrangement most familiar to the pathologist. Contents: Introduction; Diagram of a Normal Cell; Normal Cell Function; Embryology; Neoplasms; Infectious Agents; Metabolic Diseases; Renal Diseases; Skeletal Muscle and Peripheral Nerve Diseases; Index.

  14. [Quality improvement of medical diagnostic laboratories].

    Science.gov (United States)

    Horváth, Andrea Rita; Endröczi, Elemér; Mikó, Tivadar

    2003-07-13

    Service quality in medical laboratories is influenced by a number of variables. Medical laboratories have long recognized the need for total quality management that incorporates the continuous improvement of all stages, such as the pre-analytical, analytical and post-analytical phases, of the diagnostic process, in addition to the traditional internal and external quality control of analytical procedures. Based on national and international experience, continuous improvement of quality and its external assessment are of high priority in order to guarantee a reliable, effective and cost-effective diagnostic service. Certification of health care services, according to ISO 9001 standards in Hungarian hospitals, is not sufficient to prove professional competence of medical laboratories, which called for a system of laboratory accreditation. Accreditation is an external professional audit by which an independent accreditation body gives formal recognition that the medical laboratory is competent to provide high quality services that are compliant with rigorous professional standards of best practice. The primary aim of accreditation is the improvement of the quality of diagnostic services by voluntary participation, professional peer review, continuous training and education and compliance with professional standards. In vitro medical laboratories have pioneered quality control and quality assurance in health care. Based on these strengths and traditions, the introduction of the accreditation program of medical laboratories in Hungary is one of the key professional and ethical responsibilities of diagnostic professions, in order to improve the quality, efficiency and effectiveness of laboratory services during the course of Hungary's accession to the European Union.

  15. Validation Tools and Methods for Diagnostic Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The potential benefits of advanced algorithms for diagnostics and prognostics, inner-loop control, and other flight critical systems have been demonstrated in a...

  16. A randomized controlled trial to assess the impact of dietary energy sources, feed supplements, and the presence of super-shedders on the detection of Escherichia coli O157:H7 in feedlot cattle using different diagnostic procedures.

    Science.gov (United States)

    Cernicchiaro, Natalia; Pearl, David L; McEwen, Scott A; Zerby, Henry N; Fluharty, Francis L; Loerch, Steve C; Kauffman, Michael D; Bard, Jaime L; LeJeune, Jeffrey T

    2010-09-01

    Alteration of the gastro-intestinal tract through manipulation of cattle diets has been proposed as a preharvest control measure to reduce fecal shedding of Escherichia coli O157:H7. The objective of this study was to examine the effects of the energy source's moisture content (high moisture corn and dry whole-shelled corn), two natural feed supplements (Saccaromyces cerevisiae boulardii CNCM 1079-Levucell and Aspergillus oryzae-Amaferm), and two levels of vitamin A (2200 IU/kg and no supplementation) on the fecal excretion of E. coli O157:H7 in naturally infected cattle. One hundred sixty-eight Angus-cross beef steers were randomly allocated to 24 pens, and each pen was assigned 1 of 12 dietary treatments in a randomized complete block design. E. coli O157:H7 was detected by rectoanal mucosal swab (RAMS) and fecal grab samples using immunomagnetic separation (IMS) and standard microbiological techniques. On the basis of multivariable multilevel logistic regression models, we found a statistically significant (p 10(4) colony forming units of E. coli O157:H7 per gram of feces) was present in the pen at the time of testing relative to animals fed high moisture corn and nonexposed to super-shedders. However, in similar models based on RAMS-IMS testing, the effect of corn type on the prevalence of E. coli O157:H7 varied with the type of feed additive used. Being exposed to a super-shedding pen-mate also increased the odds of being positive to E. coli O157:H7 in the RAMS-IMS models. These models demonstrate that the impact of different supplements may vary with the diagnostic test used, and that further research into the biological significance of differences between RAMS- and fecal-IMS test results is warranted.

  17. Diagnostic approaches for cholangiocarcinoma

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to be challenging. Cholangiocarcinomas often grow longitudinally along the bile duct rather than in a radial direction. Thus, large tumor masses are frequently absent and imaging techniques, including ultrasound, CT, and MRI have only limited sensitivity. Tissue collection during endoscopic (ERCP) and/or percutaneous transhepatic (PTC) procedures are usually used to confirm a definitive diagnosis of cholangiocarcinoma. However, forceps biopsy and brush cytology provide positive results for malignancy in about only 50% of patients. Percutaneous and peroral cholangioscopy using fiber-optic techniques were therefore developed for direct visualization of the biliary tree, yielding additional information about endoscopic appearance and tumor extension, as well as a guided biopsy acquistion. Finally, endoscopic ultrasonography (EUS) complements endoscopic and percutaneous approaches and may provide a tissue diagnosis of tumors in the biliary region through fine- needle aspiration. In the future, new techniques allowing for early detection, including molecular markers, should be developed to improve the diagnostic sensitivity in this increasing tumor entity.

  18. Design and Research of Distributed Real TimeSurveillance Control System

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Distributed real time surveillance control system is used especially in distributed computer measure and control system, mostly inwidely dispersed measure points without human surveillance. This paper describes theory、construction、control strategy, stabilityanalysis of distributed real time supervisory control and data acquisition system, implements distributed measure signals collectionand design of supervisory control system. The realization of virtual instrument based on VC++ can accomplish measurementsignals acquisition, storage, display and analysis, also the result of surveillance control system is provided, and shows thefunctional powerful agility of virtual instrument based on VC++.

  19. Models of diagnostic relations in a wheeled tractor

    Directory of Open Access Journals (Sweden)

    Ryszard Michalski

    2014-03-01

    Full Text Available Modern wheeled tractors are equipped with new-generation electric and electronic systemswhich control the operation of actuator systems. Such solutions require an on-board computer foronline monitoring of functional performance, exhaust gas emissions, safety and operating parameters.Mechatronic diagnostic systems identify the machine’s actual operating load in different operatingmodes and under specific circumstances.Knowledge engineering methods have not yet been developed in the process of diagnosing a tractor’sdefects, but they seem to offer almost endless possibilities. A defect is defined as every event whichhas an adverse effect on tractor performance and which should be detected in the diagnostic processwith an indication of the type and place of damage as well as the magnitude and variability of damageover time. Diagnostic knowledge is a symbolic representation of empirical relations based on whichdiagnostic procedures are developed.The identification of diagnostic relations based on different methods and information sources willfoster the growth of reliable declarative knowledge comprising facts and state-symptom diagnosticrelations, as well as procedural knowledge which underlies diagnostic inference.The determination of symptom-damage relations requires a knowledge base of potential defects in theassemblies and subassemblies of a wheeled tractor. A diagnostic knowledge base can be created based on the identified diagnostic relations, including data acquired during damage simulations.The identification of diagnostic relations between specific defects and the corresponding parameterswas one of the key steps in the process of developing a mechatronic diagnostic system in a wheeledtractor. To facilitate the detection of specific defects at a given moment, a single set of diagnosticsymptoms was allocated to every defect in a wheeled tractor. Diagnostic symptoms are identified bysensors when threshold values are exceeded

  20. Diagnostic Challenges at SNS

    CERN Document Server

    Plum, M A

    2003-01-01

    The Spallation Neutron Source now being built in Oak Ridge, Tennessee, USA, accelerates an H- ion beam to 1000 MeV with an average power of 1.4 MW. The H- beam is then stripped to H+, compressed in a storage ring to a pulse length of 695 ns, and then directed onto a mercury neutron spallation target. Most of the acceleration is accomplished with superconducting rf cavities. The presence of these cavities, the high average beam power, and the large range of beam intensity in the storage ring, provide unique challenges to the beam diagnostics systems. In this talk we will discuss these challenges and some of our solutions, including the laser profile monitor system, the residual gas ionization profile monitors, and network attached devices. Measurements performed using prototype instrumentation will also be presented.

  1. Rig Diagnostic Tools

    Science.gov (United States)

    Soileau, Kerry M.; Baicy, John W.

    2008-01-01

    Rig Diagnostic Tools is a suite of applications designed to allow an operator to monitor the status and health of complex networked systems using a unique interface between Java applications and UNIX scripts. The suite consists of Java applications, C scripts, Vx- Works applications, UNIX utilities, C programs, and configuration files. The UNIX scripts retrieve data from the system and write them to a certain set of files. The Java side monitors these files and presents the data in user-friendly formats for operators to use in making troubleshooting decisions. This design allows for rapid prototyping and expansion of higher-level displays without affecting the basic data-gathering applications. The suite is designed to be extensible, with the ability to add new system components in building block fashion without affecting existing system applications. This allows for monitoring of complex systems for which unplanned shutdown time comes at a prohibitive cost.

  2. Diagnostic and forensic toxicology.

    Science.gov (United States)

    Galey, F D

    1995-12-01

    In most competent veterinary diagnostic laboratories, analytical findings are interpreted by the veterinary toxicologist to determine the significance of the finding in view of historic, clinical, and pathologic findings. A veterinary toxicologist also will provide consultation about possible toxic rule-outs for a case, treatment of affected animals, and prevention of additional cases. Once all of the information is available, a complete summary of the findings can be provided to the client. When the procedures outlined are followed, including a systematic approach to collecting all the evidence (historic, clinical, pathologic, and analytic), proper sampling techniques, and good communication between the clinician and the client and laboratory, the usefulness of the toxicology investigation will be maximized.

  3. Diagnostics and Microelectronics

    Energy Technology Data Exchange (ETDEWEB)

    Balch, J.W.

    1993-03-01

    This report discusses activities of the Diagnostics and Microelectronics thrust area which conducts activities in semiconductor devices and semiconductor fabrication technology for programs at Lawrence Livermore National Laboratory. Our multidisciplinary engineering and scientific staff use modern computational tools and semi-conductor microfabrication equipment to develop high-performance devices. Our work concentrates on three broad technologies of semiconductor microdevices: (1) silicon on III-V semiconductor microeletronics, (2) lithium niobate-based and III-V semiconductor-based photonics, and (3) silicon-based micromaching for application to microstructures and microinstruments. In FY-92, we worked on projects in seven areas, described in this report: novel photonic detectors; a wideband phase modulator; an optoelectronic terahertz beam system; the fabrication of microelectrode electrochemical sensors; diamond heatsinks; advanced micromachining technologies; and electrophoresis using silicon microchannels.

  4. Optical Diagnostics in Medicine

    Science.gov (United States)

    Iftimia, Nicusor

    2003-03-01

    Light has a unique potential for non-invasive tissue diagnosis. The relatively short wavelength of light allows imaging of tissue at the resolution of histopathology. While strong multiple scattering of light in tissue makes attainment of this resolution difficult for thick tissues, most pathology emanates from epithelial surfaces. Therefore, high-resolution diagnosis of many important diseases may be achieved by transmitting light to the surface of interest. The recent fiber-optic implementation of technologies that reject multiple scattering, such as confocal microscopy and optical low coherence interferometry, have brought us one step closer to realizing non-invasive imaging of architectural and cellular features of tissue. Optical coherence tomography (OCT) can produce high-resolution cross-sectional images of biological structures. Clinical OCT studies conducted in the gastrointestinal tract and cardiovascular system have shown that OCT is capable of providing images of the architectural (> 20 µm) microanatomy of a variety of epithelial tissues, including the layered structure of squamous epithelium and arterial vessels. Fine Needle Aspiration- Low Coherence Interferometry (FNA-LCI) is another optical diagnostics technique, which is a suitable solution to increase the effectiveness of the FNA procedures. LCI is capable of measuring depth resolved (axial, z) tissue structure, birefringence, flow (Doppler shift), and spectra at a resolution of several microns. Since LCI systems are fiber-optic based, LCI probes may easily fit within the bore of a fine gauge needle, allowing diagnostic information to be obtained directly from the FNA biopsy site. Fiber optic spectrally encoded confocal microscopy (SECM) is a new confocal microscopy method, which eliminates the need for rapid beam scanning within the optical probe. This advance enables confocal microscopy to be performed through small diameter probes and will allow assessment of internal human tissues in vivo at

  5. Oral vs. salivary diagnostics

    Science.gov (United States)

    Marques, Joana; Corby, Patricia M.; Barber, Cheryl A.; Abrams, William R.; Malamud, Daniel

    2015-05-01

    The field of "salivary diagnostics" includes studies utilizing samples obtained from a variety of sources within the oral cavity. These samples include; whole unstimulated saliva, stimulated whole saliva, duct saliva collected directly from the parotid, submandibular/sublingual glands or minor salivary glands, swabs of the buccal mucosa, tongue or tonsils, and gingival crevicular fluid. Many publications state "we collected saliva from subjects" without fully describing the process or source of the oral fluid. Factors that need to be documented in any study include the time of day of the collection, the method used to stimulate and collect the fluid, and how much fluid is being collected and for how long. The handling of the oral fluid during and post-collection is also critical and may include addition of protease or nuclease inhibitors, centrifugation, and cold or frozen storage prior to assay. In an effort to create a standard protocol for determining a biomarker's origin we carried out a pilot study collecting oral fluid from 5 different sites in the mouth and monitoring the concentrations of pro- and anti-inflammatory cytokines detected using MesoScaleDiscovery (MSD) electrochemiluminesence assays. Our data suggested that 3 of the cytokines are primarily derived from the submandibular gland, while 7 of the cytokines come from a source other than the major salivary glands such as the minor salivary glands or cells in the oral mucosae. Here we review the literature on monitoring biomarkers in oral samples and stress the need for determining the blood/saliva ratio when a quantitative determination is needed and suggest that the term oral diagnostic be used if the source of an analyte in the oral cavity is unknown.

  6. Tuberculosis diagnostic methods in buffaloes

    Directory of Open Access Journals (Sweden)

    Gabriela Capriogli Oliveira

    2015-07-01

    Full Text Available The low productivity of buffalo herds and condemnation of carcasses in slaughterhouses due to tuberculosis lesions have resulted in increasing economic losses because these animals cannot be treated and must be destroyed by sanitary slaughter. Tuberculosis is a widely distributed zoonosis that affects the beef supply chain of the Brazilian agribusiness economically and socially. Like cattle, buffaloes are sensitive to Mycobacterium bovis, which is the main causative agent of zoonotic tuberculosis. Tuberculosis in buffaloes has been reported in several countries, including Brazil. In order to control and eradicate this disease among cattle and buffaloes in Brazil, the Ministry of Agriculture, Livestock, and Supply created the National Program for the Control and Eradication of Brucellosis and Tuberculosis with the main objective of finding a significant number of disease-free herds throughout the national territory using reliable methods. This review summarizes the main data on the history of occurrence of M. bovis in Brazilian herds and the diagnostic methods for the disease in buffaloes. Little information is available on buffalo tuberculosis. Due to the increasing population of buffaloes and their economic importance, more studies investigating the occurrence and identification of tuberculosis in this species are clearly needed.

  7. Design of Electronic Belt Scale Instrument Based on ARM%基于ARM的电子皮带秤仪表设计

    Institute of Scientific and Technical Information of China (English)

    王珅玮; 李传江

    2013-01-01

    A multifunctional electronic belt scale instrument is designed, which used single -chip microcomputer as the lower computer to a-chieve data acquisition function, and ARM system as the host computer to realize cumulative volume measurement, flow control and other functions. Model free adaptive control algorithm is adopted to control belt flow. Simulation results show that the algorithm has good control performance.%设计一种多功能电子皮带秤仪表,采用单片机作为下位机,实现数据采集功能,ARM系统作为上位机,实现累积量计量、流量控制等功能;将无模型自适应控制用于皮带流量控制中,仿真结果表明,该算法具有良好的控制性能.

  8. The architecture of diagnostic research

    DEFF Research Database (Denmark)

    Colli, Agostino; Fraquelli, Mirella; Casazza, Giovanni

    2014-01-01

    of different index tests; phase 2B studies aim to evaluate the possible harms of incorporating the index test in a diagnostic-therapeutic strategy. In phase 3, diagnostic test-therapeutic randomized clinical trials aim to assess the benefits and harms of the new diagnostic-therapeutic strategy versus...... the present strategy. Phase 4 comprises large surveillance cohort studies that aim to assess the effectiveness of the new diagnostic-therapeutic strategy in clinical practice. As common in clinical research, putting excessive weight on the results of single studies and trials is likely to divert from...

  9. Diagnostics development plan for ZR.

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, David Lester

    2003-09-01

    The Z Refurbishment (ZR) Project is a program to upgrade the Z machine at SNL with modern durable pulsed power technology, providing additional shot capacity and improved reliability as well as advanced capabilities for both pulsed x-ray production and high pressure generation. The development of enhanced diagnostic capabilities is an essential requirement for ZR to meet critical mission needs. This report presents a comprehensive plan for diagnostic instrument and infrastructure development for the first few years of ZR operation. The focus of the plan is on: (1) developing diagnostic instruments with high spatial and temporal resolution, capable of low noise operation and survival in the severe EMP, bremsstrahlung, and blast environments of ZR; and (2) providing diagnostic infrastructure improvements, including reduced diagnostic trigger signal jitter, more and flexible diagnostic line-of-sight access, and the capability for efficient exchange of diagnostics with other laboratories. This diagnostic plan is the first step in an extended process to provide enhanced diagnostic capabilities for ZR to meet the diverse programmatic needs of a broad range of defense, energy, and general science programs of an international user community into the next decade.

  10. Exposure Control Methods and Termination Rules in Variable-Length Cognitive Diagnostic Computerized Adaptive Testing%变长CD-CAT中的曝光控制与终止规则

    Institute of Scientific and Technical Information of China (English)

    郭磊; 郑蝉金; 边玉芳

    2015-01-01

    Comparing to the nonadaptive testing, the major advantage of computerized adaptive testing (CAT) is that the examinees achieve the same degree of measurement precision (i.e., fixed precision). But few studies are devoted to the termination rules in variable-length cognitive diagnostic computerized adaptive testing (CD-CAT). Inspired by the termination rule research in traditional CAT, this paper proposed four termination rules for variable-length CD-CAT. The new termination rules were standard error of attribute method (SEA), difference of the adjacent posterior probability method (DAPP), halving algorithm (HA) and hybrid method (HM), respectively. Then, the four new termination rules were compared with the HSU and KL method under two scenarios: with and without item exposure control. Three exposure control methods were considered, i.e., simple, modified restrictive progressive (MRP) and modified restrictive threshold (MRT) method. The MRP and MRT methods were extension of the Wang et al.’s (2011) work to the variable-length CD-CAT scenario. (1) When the criterion of variable-length termination rule was conservative, the mean of the test length and the percentage of examinees reaching the maximum test length were large, and the classification accuracy rate for examinees who finished the CAT using fixed precision was high. (2) Without the item exposure control, the four new variable-length termination rules had a similar performance compared to the HSU method. With the increase of maximum posterior probability and the decrease ofε, the classification accuracy rate and the mean test length presented a increasing trend. But the item pool usage was unsatisfactory. (3) With the item exposure control, item pool usage was greatly improved in the six variable-length termination rules while the classification accuracy rates were maintained. Different exposure control methods had a different effect on the different variable-length termination rules. The relative criterion

  11. Cognitive Diagnostic Assessment via Bayesian Evaluation of Informative Diagnostic Hypotheses

    NARCIS (Netherlands)

    Hoitink, Herbert; Beland, Sebastien; Vermeulen, Jorine A.

    2014-01-01

    There exist diverse approaches that can be used for cognitive diagnostic assessment, such as mastery testing, constrained latent class analysis, rule space methodology, diagnostic cognitive modeling, and person-fit analysis. Each of these approaches can be used within 1 of the 4 psychometric perspec

  12. Cognitive diagnostic assessment via Bayesian evaluation of informative diagnostic hypotheses.

    NARCIS (Netherlands)

    Hoijtink, Herbert; Béland, Sébastien; Vermeulen, Jorine A.

    2014-01-01

    There exist diverse approaches that can be used for cognitive diagnostic assessment, such as mastery testing, constrained latent class analysis, rule space methodology, diagnostic cognitive modeling, and person-fit analysis. Each of these approaches can be used within 1 of the 4 psychometric perspec

  13. Ares I-X Ground Diagnostic Prototype

    Science.gov (United States)

    Schwabacher, Mark A.; Martin, Rodney Alexander; Waterman, Robert D.; Oostdyk, Rebecca Lynn; Ossenfort, John P.; Matthews, Bryan

    2010-01-01

    The automation of pre-launch diagnostics for launch vehicles offers three potential benefits: improving safety, reducing cost, and reducing launch delays. The Ares I-X Ground Diagnostic Prototype demonstrated anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage Thrust Vector Control and for the associated ground hydraulics while the vehicle was in the Vehicle Assembly Building at Kennedy Space Center (KSC) and while it was on the launch pad. The prototype combines three existing tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool from Qualtech Systems Inc. for fault isolation and diagnostics. The second tool, SHINE (Spacecraft Health Inference Engine), is a rule-based expert system that was developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification, and used the outputs of SHINE as inputs to TEAMS. The third tool, IMS (Inductive Monitoring System), is an anomaly detection tool that was developed at NASA Ames Research Center. The three tools were integrated and deployed to KSC, where they were interfaced with live data. This paper describes how the prototype performed during the period of time before the launch, including accuracy and computer resource usage. The paper concludes with some of the lessons that we learned from the experience of developing and deploying the prototype.

  14. Status of ITER neutron diagnostic development

    Science.gov (United States)

    Krasilnikov, A. V.; Sasao, M.; Kaschuck, Yu. A.; Nishitani, T.; Batistoni, P.; Zaveryaev, V. S.; Popovichev, S.; Iguchi, T.; Jarvis, O. N.; Källne, J.; Fiore, C. L.; Roquemore, A. L.; Heidbrink, W. W.; Fisher, R.; Gorini, G.; Prosvirin, D. V.; Tsutskikh, A. Yu.; Donné, A. J. H.; Costley, A. E.; Walker, C. I.

    2005-12-01

    Due to the high neutron yield and the large plasma size many ITER plasma parameters such as fusion power, power density, ion temperature, fast ion energy and their spatial distributions in the plasma core can be measured well by various neutron diagnostics. Neutron diagnostic systems under consideration and development for ITER include radial and vertical neutron cameras (RNC and VNC), internal and external neutron flux monitors (NFMs), neutron activation systems and neutron spectrometers. The two-dimensional neutron source strength and spectral measurements can be provided by the combined RNC and VNC. The NFMs need to meet the ITER requirement of time-resolved measurements of the neutron source strength and can provide the signals necessary for real-time control of the ITER fusion power. Compact and high throughput neutron spectrometers are under development. A concept for the absolute calibration of neutron diagnostic systems is proposed. The development, testing in existing experiments and the engineering integration of all neutron diagnostic systems into ITER are in progress and the main results are presented.

  15. Current possibilities of chorioretinites diagnostics

    Directory of Open Access Journals (Sweden)

    O. V. Chudinova

    2014-07-01

    Full Text Available Purpose: to study the morphometric changes in retina and the state of regional hemodynamics for chorioretinites of different etiology, to draw parallels between these methods of study with evaluation of their diagnostical significance.Methods: Clinical and instrumental examination was performed in 15 patients (15 eyes — group 1 — with the verified diagnosis of toxoplasmous chorioretinitis and in 13 patients (13 eyes — group 2 — with the diagnosis of tuberculous chorioretinitis. Control (group 3 consisted of 20 subjects (40 eyes, 9 males, 11 females, without any pathology of organ of vision. Complex ophthalmologic examination was performed in all the patients; the examination included the following procedures: determination of visual acuity with correction, computer perimetry, biomicroscopy of eye fundus, inspection of eye fundus using Goldman lens, optic coherent tomogra- phy (OCt, ultrasound Dopplerography (USDG of eye vessels.Results: the following was determined by OCt data: subclinical serous retinal detachment, isolated cells of cyst-like edema, cyst- like edema in macular zone, unevenness of hyperreflective band of pigment epithelium, thinning of neurosensory retina in the area of scarry focus, hyperreflectivity of the zone of the fibrosis being formed, architectonics disorder of NE layers in foveolar zone and para- foveally at the expense of the presence of small hyperreflective parts. In the presence of proliferative process in the vascular coat the reliable decrease of blood flow maximal and minimal velocities in the posterior short ciliary arteries, maximal and minimal velocities of blood flow in the posterior long ciliary arteries in comparison with the values of patients from control group. the data obtained are supposed that proliferative processes in the vascular coat are accompanied by marked local hemodynamic disorders, which should be taken into consideration when complex therapy is prescribed.Conclusion: Dynamic

  16. Comparative guide to emerging diagnostic tools for large commercial HVAC systems

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Hannah; Piette, Mary Ann

    2001-05-01

    This guide compares emerging diagnostic software tools that aid detection and diagnosis of operational problems for large HVAC systems. We have evaluated six tools for use with energy management control system (EMCS) or other monitoring data. The diagnostic tools summarize relevant performance metrics, display plots for manual analysis, and perform automated diagnostic procedures. Our comparative analysis presents nine summary tables with supporting explanatory text and includes sample diagnostic screens for each tool.

  17. New recognition on control concept of mercury hazards and diagnostic criteria of mercury poisoning%对汞危害防治理念与汞中毒诊断标准的新认知

    Institute of Scientific and Technical Information of China (English)

    郝克文; 郭友东; 黄蓉; 余素娥; 金环荣

    2012-01-01

    Mercury is a heavy metal toxic substance of occupation hazard factor, which has irritation, immune pathogenicity, renal toxicity, neurotoxicity and oral toxicity, it may cause serious harm to health and safety of workers, and the serious should induce poisoning. The control and prevention of mercury hazards has always been the major task of occupational health and occupational medicine in China, and mercury hazards is one of occupational diseases that government make a law to ensure the health and safety of workers. Based on the national conditions, there are only prevention regulations and diagnostic criteria according to occupational mercury hazards in the foretime, and is lack of prevention and diagnosis of non-occupational mercury hazards. Therefore, the authors review the new recognition of non-occupational hazards of mercury and diagnosis of non-occupational mercury poisoning by literature review and working practice.%汞作为职业病危害因素的一种重金属高毒物质,因其具有刺激性、免疫致病性、肾脏毒性、神经毒性、口腔毒性等,对劳动者的健康与安全危害较强,严重者可致中毒.对于汞危害的防治,历来是国家职业卫生与职业医学的主要任务,也是党和政府为保护广大劳动者健康与安全,立法开展的职业病防治工作之一.立于国情,先前只从职业性汞危害的角度制定了防治法规和诊断标准,对非职业性汞危害防治、诊断的问题有所疏漏.为此,作者从非职业性汞危害与非职业性汞中毒诊断的层面,通过文献复习及工作实践获得的一些新认知做一综述.

  18. Plasma diagnostics discharge parameters and chemistry

    CERN Document Server

    Auciello, Orlando

    1989-01-01

    Plasma Diagnostics, Volume 1: Discharge Parameters and Chemistry covers seven chapters on the important diagnostic techniques for plasmas and details their use in particular applications. The book discusses optical diagnostic techniques for low pressure plasmas and plasma processing; plasma diagnostics for electrical discharge light sources; as well as Langmuir probes. The text also describes the mass spectroscopy of plasmas, microwave diagnostics, paramagnetic resonance diagnostics, and diagnostics in thermal plasma processing. Electrical engineers, nuclear engineers, microwave engineers, che

  19. Status of US ITER Diagnostics

    Science.gov (United States)

    Stratton, B.; Delgado-Aparicio, L.; Hill, K.; Johnson, D.; Pablant, N.; Barnsley, R.; Bertschinger, G.; de Bock, M. F. M.; Reichle, R.; Udintsev, V. S.; Watts, C.; Austin, M.; Phillips, P.; Beiersdorfer, P.; Biewer, T. M.; Hanson, G.; Klepper, C. C.; Carlstrom, T.; van Zeeland, M. A.; Brower, D.; Doyle, E.; Peebles, A.; Ellis, R.; Levinton, F.; Yuh, H.

    2013-10-01

    The US is providing 7 diagnostics to ITER: the Upper Visible/IR cameras, the Low Field Side Reflectometer, the Motional Stark Effect diagnostic, the Electron Cyclotron Emission diagnostic, the Toroidal Interferometer/Polarimeter, the Core Imaging X-Ray Spectrometer, and the Diagnostic Residual Gas Analyzer. The front-end components of these systems must operate with high reliability in conditions of long pulse operation, high neutron and gamma fluxes, very high neutron fluence, significant neutron heating (up to 7 MW/m3) , large radiant and charge exchange heat flux (0.35 MW/m2) , and high electromagnetic loads. Opportunities for repair and maintenance of these components will be limited. These conditions lead to significant challenges for the design of the diagnostics. Space constraints, provision of adequate radiation shielding, and development of repair and maintenance strategies are challenges for diagnostic integration into the port plugs that also affect diagnostic design. The current status of design of the US ITER diagnostics is presented and R&D needs are identified. Supported by DOE contracts DE-AC02-09CH11466 (PPPL) and DE-AC05-00OR22725 (UT-Battelle, LLC).

  20. Motor neurone disease: diagnostic pitfalls.

    Science.gov (United States)

    Williams, Timothy L

    2013-02-01

    The misdiagnosis of MND (particularly of the ALS phenotype), is uncommon. Atypical presentations, particularly of focal onset and with pure LMN or UMN signs, present a more difficult diagnostic challenge, although perhaps reassuringly, treatable mimics are rare. A working knowledge of potential alternative conditions and MND diagnostic pitfalls should help to reduce the misdiagnosis rate, particularly if the key points are considered.

  1. Pyomyositis tropicans: a diagnostic dilemma.

    Science.gov (United States)

    Chaitow, J; Martin, H C; Knight, P; Buchanan, N

    1980-11-01

    Pyomyositis tropicans is a rare disease in non-tropical climates and thus presents diagnostic difficulties. Two children with single staphylococcal psoas muscle abscesses were recently successfully treated. Computerized axial tomography was found to be a useful diagnostic aid, allowing exact localization of the lesion. The diagnosis and therapy of these abscesses are discussed.

  2. Dual Processing and Diagnostic Errors

    Science.gov (United States)

    Norman, Geoff

    2009-01-01

    In this paper, I review evidence from two theories in psychology relevant to diagnosis and diagnostic errors. "Dual Process" theories of thinking, frequently mentioned with respect to diagnostic error, propose that categorization decisions can be made with either a fast, unconscious, contextual process called System 1 or a slow, analytical,…

  3. Verification of Loop Diagnostics

    Science.gov (United States)

    Winebarger, A.; Lionello, R.; Mok, Y.; Linker, J.; Mikic, Z.

    2014-01-01

    Many different techniques have been used to characterize the plasma in the solar corona: density-sensitive spectral line ratios are used to infer the density, the evolution of coronal structures in different passbands is used to infer the temperature evolution, and the simultaneous intensities measured in multiple passbands are used to determine the emission measure. All these analysis techniques assume that the intensity of the structures can be isolated through background subtraction. In this paper, we use simulated observations from a 3D hydrodynamic simulation of a coronal active region to verify these diagnostics. The density and temperature from the simulation are used to generate images in several passbands and spectral lines. We identify loop structures in the simulated images and calculate the loop background. We then determine the density, temperature and emission measure distribution as a function of time from the observations and compare with the true temperature and density of the loop. We find that the overall characteristics of the temperature, density, and emission measure are recovered by the analysis methods, but the details of the true temperature and density are not. For instance, the emission measure curves calculated from the simulated observations are much broader than the true emission measure distribution, though the average temperature evolution is similar. These differences are due, in part, to inadequate background subtraction, but also indicate a limitation of the analysis methods.

  4. [Diagnostic imaging of lying].

    Science.gov (United States)

    Lass, Piotr; Sławek, Jarosław; Sitek, Emilia; Szurowska, Edyta; Zimmermann, Agnieszka

    2013-01-01

    Functional diagnostic imaging has been applied in neuropsychology for more than two decades. Nowadays, the functional magnetic resonance (fMRI) seems to be the most important technique. Brain imaging in lying has been performed and discussed since 2001. There are postulates to use fMRI for forensic purposes, as well as commercially, e.g. testing the loyalty of employees, especially because of the limitations of traditional polygraph in some cases. In USA fMRI is performed in truthfulness/lying assessment by at least two commercial companies. Those applications are a matter of heated debate of practitioners, lawyers and specialists of ethics. The opponents of fMRI use for forensic purposes indicate the lack of common agreement on it and the lack of wide recognition and insufficient standardisation. Therefore it cannot serve as a forensic proof, yet. However, considering the development of MRI and a high failure rate of traditional polygraphy, forensic applications of MRI seem to be highly probable in future.

  5. Diagnostic of Horndeski theories

    Science.gov (United States)

    Perenon, Louis; Marinoni, Christian; Piazza, Federico

    2017-01-01

    We study the effects of Horndeski models of dark energy on the observables of the large-scale structure in the late time universe. A novel classification into Late dark energy, Early dark energy and Early modified gravity scenarios is proposed, according to whether such models predict deviations from the standard paradigm persistent at early time in the matter domination epoch. We discuss the physical imprints left by each specific class of models on the effective Newton constant μ, the gravitational slip parameter η, the light deflection parameter Σ and the growth function fσ8 and demonstrate that a convenient way to dress a complete portrait of the viability of the Horndeski accelerating mechanism is via two, redshift-dependent, diagnostics: the μ(z) ‑ Σ(z) and the fσ8(z) ‑ Σ(z) planes. If future, model-independent, measurements point to either Σ ‑ 1 zero or μ ‑ 1 0 at high redshifts or μ ‑ 1 > 0 with Σ ‑ 1 1.5 then Early dark energy models are definitely ruled out. On the opposite case, Late dark energy models are rejected by data if Σ 1, only Early modifications of gravity provide a viable framework to interpret data.

  6. Diagnostic of Horndeski Theories

    CERN Document Server

    Perenon, Louis; Piazza, Federico

    2016-01-01

    We study the effects of Horndeski models of dark energy on the observables of the large-scale structure in the late time universe. A novel classification into {\\it Late dark energy}, {\\it Early dark energy} and {\\it Early modified gravity} scenarios is proposed, according to whether such models predict deviations from the standard paradigm persistent at early time in the matter domination epoch. We discuss the physical imprints left by each specific class of models on the effective Newton constant $\\mu$, the gravitational slip parameter $\\eta$, the light deflection parameter $\\Sigma$ and the growth function $f\\sigma_8$ and demonstrate that a convenient way to dress a complete portrait of the viability of the Horndeski accelerating mechanism is via two, redshift-dependent, diagnostics: the $\\mu(z)-\\Sigma(z)$ and the $f\\sigma_8(z)-\\Sigma(z)$ planes. If future, model-independent, measurements point to either $\\Sigma-10$ at high redshifts or $\\mu-1>0$ with $\\Sigma-11.5$ then Early dark energy models are definitel...

  7. Diagnostic neuroimaging across diseases

    Science.gov (United States)

    Klöppel, Stefan; Abdulkadir, Ahmed; Jack, Clifford R.; Koutsouleris, Nikolaos; Mourao-Miranda, Janaina; Vemuri, Prashanthi

    2012-01-01

    Fully automated classification algorithms have been successfully applied to diagnose a wide range of neurological and psychiatric diseases. They are sufficiently robust to handle data from different scanners for many applications and in specific cases outperform radiologists. This article provides an overview of current applications taking structural imaging in Alzheimer's Disease and schizophrenia as well as functional imaging to diagnose depression as examples. In this context, we also report studies aiming to predict the future course of the disease and the response to treatment for the individual. This has obvious clinical relevance but is also important for the design of treatment studies that may aim to include a cohort with a predicted fast disease progression to be more sensitive to detect treatment effects. In the second part, we present our own opinions on i) the role these classification methods can play in the clinical setting; ii) where their limitations are at the moment and iii) how those can be overcome. Specifically, we discuss strategies to deal with disease heterogeneity, diagnostic uncertainties, a probabilistic framework for classification and multi-class classification approaches. PMID:22094642

  8. Gonorrhoea diagnostics: An update

    Directory of Open Access Journals (Sweden)

    R Verma

    2016-01-01

    Full Text Available Diagnosis of gonorrhoea is an ongoing challenge. The organism is fastidious requiring meticulous collection and transport for successful cultivation. Asymptomatic infections are common which go undetected by conventional methods thereby leading to continued transmission and the risk of complications. The nucleic acid amplification tests, now increasingly used in developed countries, offer improved sensitivity compared to bacterial culture. However, these continue to suffer sequence related problems leading to false positive and false negative results. Further, these cannot be used for generation of data on antibiotic susceptibility because genetic markers of antibiotic resistance to recommended therapies have not been fully characterised. They are unaffordable in a setting like ours where reliance is placed on syndromic approach for sexually transmitted infection (STI management. The use of syndromic approach has resulted in a considerable decline in the number of Neisseria gonorrhoeae isolates that have been cultured for diagnostic purposes. Many laboratories formerly doing so are no longer performing culture for gonococci, and the basic skills have been lost. There is a need to not only revive this skill but also adopt newer technologies that can aid in accurate diagnosis in a cost-effective manner. There is room for innovation that can facilitate the development of a point-of-care test for this bacterial STI.

  9. Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics.

    Science.gov (United States)

    Wang, Lei; Li, Li-li; Fan, Yun-shan; Wang, Hao

    2013-07-26

    Extensive efforts have been devoted to the construction of functional supramolecular nanosystems for applications in catalysis, energy conversion, sensing and biomedicine. The applications of supramolecular nanosystems such as liposomes, micelles, inorganic nanoparticles, carbon materials for cancer diagnostics and therapeutics have been reviewed by other groups. Here, we will focus on the recent momentous advances in the implementation of typical supramolecular hosts (i.e., cyclodextrins, calixarenes, cucurbiturils and metallo-hosts) and their nanosystems in cancer diagnostics and therapeutics. We discuss the evolutive process of supramolecular nanosystems from the structural control and characterization to their diagnostic and therapeutic function exploitation and even the future potentials for clinical translation.

  10. Beam Diagnostic Devices and Data Acquisition for the HICAT Facility

    CERN Document Server

    Peters, A; Schwickert, M

    2005-01-01

    A set of 92 diagnostic devices for beam diagnostics in the heavy ion cancer therapy facility (HICAT) at the university hospital in Heidelberg is currently under development at GSI. For the HICAT facility that is presently under construction, all beam diagnostic devices will be fully computer controlled and will allow an automated detection of all relevant beam parameters. The HICAT raster scan method with active variation of intensity, energy and beam size requires the exact knowledge of the time resolved and spatial structure of the ion beam. An overview of the integrated devices is presented, particularly the time-of-flight method for energy measurement in the Linac is described in detail. The real-time PXI data acquisition system using Acqiris ADC modules with a sampling rate of 4 GSa/s and 1 GHz analog bandwidth, is reviewed. Additionally, the embedding of the diagnostics devices in the timing and control system of HICAT is described.

  11. Plasma diagnostics for tokamaks and stellarators

    Energy Technology Data Exchange (ETDEWEB)

    Stott, P. E.; Sanchez, J.

    1994-07-01

    A collection of papers on plasma diagnostics is presented. The papers show the state of the art developments in a series of techniques: Magnetic diagnostics, Edge diagnostics, Langmuir probes, Spectroscopy, Microwave and FIR diagnostics as well as Thomson Scattering. Special interest was focused on those diagnostics oriented to fluctuations measurements in the plasma. (Author) 451 refs.

  12. Diagnostic Challenges in AIH

    Directory of Open Access Journals (Sweden)

    A Taghavi Ardakani

    2014-04-01

    Full Text Available Autoimmune hepatitis is a chronic hepatitis that occurs in children and adults of all ages. Diagnosis is based upon characteristic serologic and histologic findings and the exclusion of other forms of chronic liver disease. Guidelines issued by the AASLD suggest the following diagnostic considerations: The diagnosis should be made in patients with compatible clinical signs, symptoms, and laboratory abnormalities. Other conditions that can cause chronic hepatitis should be excluded. In unclear cases a standardized scoring system should be used in the assessment. In those who are negative for conventional autoantibodies, additional autoantibodies should be sought. All patients with autoimmune hepatitis and inflammatory bowel disease should undergo cholangiographic studies to exclude primary sclerosing cholangitis.   Scoring systems- A scoring system developed and subsequently revised by the International Autoimmune Hepatitis Group to standardize the diagnosis with using simplified criteria based upon titers of autoantibodies, IgG levels, liver histology, and the exclusion of viral hepatitis. Autoantibodies: assign one point if the ANA or SMA are 1:40 OR assign two points if the ANA or SMA are ≥1:80 (OR if the LKM ≥1:40 OR if the SLA is positive. IgG: assign one point if the IgG is > the upper limit of normal OR assign two points if the IgG is >1.10 times the upper limit of normal. Liver histology: assign one point if the histological features are compatible with autoimmune hepatitis OR two points if the histological features are typical of autoimmune hepatitis. Absence of viral hepatitis A probable diagnosis of autoimmune hepatitis is made if the total points are six, while a definite diagnosis is made if the total points are ≥seven.  

  13. Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD-'Assessing QbTest Utility in ADHD' (AQUA): a randomised controlled trial.

    Science.gov (United States)

    Hall, Charlotte L; Walker, Gemma M; Valentine, Althea Z; Guo, Boliang; Kaylor-Hughes, Catherine; James, Marilyn; Daley, David; Sayal, Kapil; Hollis, Chris

    2014-12-01

    The National Institute for Health and Care Excellence (NICE) guidelines for attention deficit/hyperactivity disorder (ADHD) state that young people need to have access to the best evidence-based care to improve outcome. The current 'gold standard' ADHD diagnostic assessment combines clinical observation with subjective parent, teacher and self-reports. In routine practice, reports from multiple informants may be unavailable or contradictory, leading to diagnostic uncertainty and delay. The addition of objective tests of attention and activity may help reduce diagnostic uncertainty and delays in initiating treatment leading to improved outcomes. This trial investigates whether providing clinicians with an objective report of levels of attention, impulsivity and activity can lead to an earlier, and more accurate, clinical diagnosis and improved patient outcome. This multisite randomised controlled trial will recruit young people (aged 6-17 years old) who have been referred for an ADHD diagnostic assessment at Child and Adolescent Mental Health Services (CAMHS) and Community Paediatric clinics across England. Routine clinical assessment will be augmented by the QbTest, incorporating a continuous performance test (CPT) and infrared motion tracking of activity. The participant will be randomised into one of two study arms: QbOpen (clinician has immediate access to a QbTest report): QbBlind (report is withheld until the study end). Primary outcomes are time to diagnosis and diagnostic accuracy. Secondary outcomes include clinician's diagnostic confidence and routine clinical outcome measures. Cost-effective analysis will be conducted, alongside a qualitative assessment of the feasibility and acceptability of incorporating QbTest in routine practice. The findings from the study will inform commissioners, clinicians and managers about the feasibility, acceptability, clinical utility and cost-effectiveness of incorporating QbTest into routine diagnostic assessment of young

  14. Diagnostic systems in DEMO: engineering design issues

    CERN Document Server

    Todd, T N

    2014-01-01

    The diagnostic systems of DEMO that are mounted on or near the torus, whether intended for the monitoring and control functions of the engineering aspects or the physics behaviour of the machine, will have to be designed to suit the hostile nuclear environment. This will be necessary not just for their survival and correct functioning but also to satisfy the pertinent regulatory bodies, especially where any of them relate to machine protection or the prevention or mitigation of accidents foreseen in the safety case. This paper aims to indicate the more important of the reactor design considerations that are likely to apply to diagnostics for DEMO, drawn from experience on JET, the provisions in hand for ITER and modelling results for the wall erosion and neutron damage effects in DEMO.

  15. Nike Facility Diagnostics and Data Acquisition System

    Science.gov (United States)

    Chan, Yung; Aglitskiy, Yefim; Karasik, Max; Kehne, David; Obenschain, Steve; Oh, Jaechul; Serlin, Victor; Weaver, Jim

    2013-10-01

    The Nike laser-target facility is a 56-beam krypton fluoride system that can deliver 2 to 3 kJ of laser energy at 248 nm onto targets inside a two meter diameter vacuum chamber. Nike is used to study physics and technology issues related to laser direct-drive ICF fusion, including hydrodynamic and laser-plasma instabilities, material behavior at extreme pressures, and optical and x-ray diagnostics for laser-heated targets. A suite of laser and target diagnostics are fielded on the Nike facility, including high-speed, high-resolution x-ray and visible imaging cameras, spectrometers and photo-detectors. A centrally-controlled, distributed computerized data acquisition system provides robust data management and near real-time analysis feedback capability during target shots. Work supported by DOE/NNSA.

  16. Diagnostics For Recirculating And Energy Recovered Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Geoffrey A. Krafft; Jean-Claude Denard

    2002-12-18

    In this paper, the electron beam diagnostics developed for recirculating electron accelerators will be reviewed. The main novelties in dealing with such accelerators are: to have sufficient information and control possibilities for the longitudinal phase space, to have means to accurately set the recirculation path length, and to have a means to distinguish the beam passes on measurements of position in the linac proper. The solutions to these problems obtained at Jefferson Laboratory and elsewhere will be discussed. In addition, more standard instrumentation (profiling and emittance measurements) will be reviewed in the context of recirculating linacs. Finally, and looking forward, electron beam diagnostics for applications to high current energy recovered linacs will be discussed.

  17. [Novel methods for dementia diagnostics].

    Science.gov (United States)

    Wiltfang, J

    2015-04-01

    Novel diagnostic methods, such as cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) and [18F] amyloid positron emission tomography (PET) are meanwhile recommended for specific indications by international guidelines for the improved early and differential diagnostics of multigenic (sporadic) Alzheimer's dementia (AD). In the case of CSF-NDD the German neuropsychiatric guidelines have already been validated on the S3 level of evidence (http://www.DGPPN.de) and the additional consideration of [18F] amyloid-PET in the current update of the guidelines is to be expected. By means of CSF-NDD and/or [18F] amyloid-PET a predictive diagnosis of incipient (preclinical) AD is also possible for patients at high risk for AD who are in prodromal stages, such as mild cognitive impairment (MCI). As accompanying (secondary) preventive therapy of AD cannot be offered a predictive molecular dementia diagnostics is not recommended by the German neuropsychiatric dementia guidelines (http://www.DGPPN.de). However, novel diagnostic approaches, which offer molecular positive diagnostics of AD have already gained high relevance in therapy research as they allow promising preventive treatment avenues to be validated directly in the clinical trial. Moreover, future blood-based dementia diagnostics by means of multiplex assays is becoming increasingly more feasible; however, so far corresponding proteomic or epigenetic assays could not be consistently validated in independent studies.

  18. [BMW diagnostic criteria for IBS].

    Science.gov (United States)

    Matsueda, Kei

    2006-08-01

    Rome I diagnostic criteria for IBS was published in 1992 and it became a global diagnostic criteria. However, the criteria was not practical and somewhat complicated. Moreover, its symptomatic duration was too long (defined as more than 3 months) to be introduced in clinical practice. Therefore, Japanese member of BMW(Bowel Motility Workshop) tried to develop a new diagnostic criteria for IBS and it was established in 1995 by way of the Delphi method. The criteria was named as BMW diagnostic criteria and it was shown below: BMW diagnostic criteria for IBS (1995) At least one month or more of repetitive symptoms of the following 1) and 2) and no evidence of organic disease that likely to explain the symptoms. 1) Existence of abdominal pain, abdominal discomfort or abdominal distension 2) Existence of abnormal bowel movement (diarrhea, constipation) Abnormal bowel movement includes at least one of the below; (1) Abnormal stool frequency (2) Abnormal stool form (lumpy/hard or loose/wartery stool) Moreover, the following test should be performed as a rule to exclude organic diseases. (1) Urinalysis, fecal occult blood testing, CBC, chemistry (2) Barium enema or colonofiberscopic examination The other diagnostic criteria for IBS was also reviewed and their characteristics were compared with BMW diagnostic criteria.

  19. Proposed Diagnostic Criteria for the DSM-5 of Nonsuicidal Self-Injury in Female Adolescents: Diagnostic and Clinical Correlates

    Directory of Open Access Journals (Sweden)

    Tina In-Albon

    2013-01-01

    Full Text Available Nonsuicidal self-injury (NSSI is included as conditions for further study in the DSM-5. Therefore, it is necessary to investigate the proposed diagnostic criteria and the diagnostic and clinical correlates for the validity of a diagnostic entity. The authors investigated the characteristics of NSSI disorder and the proposed diagnostic criteria. A sample of 73 female inpatient adolescents and 37 nonclinical adolescents (aged 13 to 19 years was recruited. Patients were classified into 4 groups (adolescents with NSSI disorder, adolescents with NSSI without impairment/distress, clinical controls without NSSI, and nonclinical controls. Adolescents were compared on self-reported psychopathology and diagnostic cooccurrences. Results indicate that adolescents with NSSI disorder have a higher level of impairment than adolescents with other mental disorders without NSSI. Most common comorbid diagnoses were major depression, social phobia, and PTSD. There was some overlap of adolescents with NSSI disorder and suicidal behaviour and borderline personality disorder, but there were also important differences. Results further suggest that the proposed DSM-5 diagnostic criteria for NSSI are useful and necessary. In conclusion, NSSI is a highly impairing disorder characterized by high comorbidity with various disorders, providing further evidence that NSSI should be a distinct diagnostic entity.

  20. Recent results on ITER plasma equilibrium diagnostics and identification

    Energy Technology Data Exchange (ETDEWEB)

    Albanese, R.; Coccorese, E.; Morabito, F.C.; Pironti, A.; Versaci, M. [Associazione CREATE/ENEA/EURATOM - DIMET, Loc. Feo di Vito, Reggio Calabria (Italy); Mc Carthy, P.J. [Cork Univ. College (Ireland). Physics Dept.

    1998-07-01

    The most recent results achieved by our work-group on the plasma shape and position identification problem as well as on the interpretation of magnetic diagnostics are presented. The proposed test cases are related to the most recent configuration of sensors and geometry specification available from ITER. One of the aims of the work is also to give some design directions about the problem of optimal selection of the diagnostics for control parameters. (author)

  1. Monitoring and diagnostics of special-purpose turbomachines

    OpenAIRE

    Małgorzata Gizelska

    2015-01-01

    In the operation of special-purpose turbomachines, diagnostic tools are necessary. They enable control of the machine technical state and its operation parameters in the on-line mode. The acquisition and processing of the measurement data in real time is crucial as they are indicators of the machine functioning under various operating conditions. The paper presents two types of computer designed diagnostic tools to monitor in real time the dynamic and thermodynamic par...

  2. 基于虚拟仪器的汽车仪表设计%Design of Automobile Instrument Based on Virtual Instrument

    Institute of Scientific and Technical Information of China (English)

    杨小新

    2012-01-01

    以PC机、NI公司PCI-6221板卡、NI信号调理模块(应变、RTD、TC等)为硬件平台,以CSY.200(IC传感器与测控技术实验台为测控对象,以LabVIEW8.2为软件开发平台,设计汽车虚拟数字化仪表模拟机,可以实现日期/时间、总里程、当前速度、转速、温度、油箱存油量等信息的显示,实现汽车仪表的校验和标定。%The PC, PCI-6221 interface card of NI company, NI signal disposal module (strain, RTD, TC, etc.) are used as the hardware platform. CSY-2000 C sensor and measurement & control technology experiment platform are used as the measurement and control object. The LabVIEW8.2 is used as the software development platform. The automobile digital virtual instrument simulator is designed. The information of date/time, total mileage, the current speed, speed, temperature, oil in the tank can be displayed. The automobile meter calibration is implemented.

  3. 基于LabVIEW的蓄电池内阻测试仪的设计%Design of Battery Internal Resistance Measuring Instrument Based on LabVIEW

    Institute of Scientific and Technical Information of China (English)

    刘登峰; 邵天章; 王琳

    2011-01-01

    采用暂态直流小电流电量比较法对蓄电池内阻进行测试,设计了上位机数据采集控制软件,构建了基于LabVIEW组成的实时内阻测量系统.实际运行表明,该系统实现并提高了蓄电池内阻测试的准确性和稳定性.%The battery resistance was tested by the transient DC of small current method. The data collection and control software used on upper PC was designed, and the real-time battery resistance measurement system was established. Actual operation shows that the system improved the accuracy and stability of battery resistance testing.

  4. Diagnostics for the National Compact Stellarator Experiment

    Energy Technology Data Exchange (ETDEWEB)

    B.C. Stratton; D. Johnson; R. Feder; E. Fredrickson; H. Neilson; H. Takahashi; M. Zarnstorf; M. Cole; P. Goranson; E. Lazarus; B. Nelson

    2003-09-16

    The status of planning of the National Compact Stellarator Experiment (NCSX) diagnostics is presented, with the emphasis on resolution of diagnostics access issues and on diagnostics required for the early phases of operation.

  5. Prenatal Genetic Diagnostic Tests

    Science.gov (United States)

    ... is taken from the placenta. The two main advantages of having CVS over amniocentesis are that 1) ... the development of a person’s physical traits and control of the processes in the ... birth defect that causes intellectual disability, blindness, seizures, and ...

  6. Diagnostic Process of Company Productivity

    Directory of Open Access Journals (Sweden)

    Emese Tokarˇcíková

    2009-12-01

    Full Text Available This paper deals with an actual topic of how key factors of enterprise diagnostics can help to increase company productivity. Recognition and use of relevant internal and external information in this field determines the success of the enterprise. Application of the general diagnostic model of company productivity to the net income has been a frequent problem of company practice. This problem is of profit showing, which is an inevitable precondition for long-term company development and growth. Diagnostic access of company productivity allows recognition of specific problems in greater detail, which results from the activity of each company. This article also presents an introduction to the researched area of enterprise diagnostics, which opens opportunities for other publishing activities and can lead to information exchange.

  7. FEL-accelerator related diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kevin Jordan; David Douglas; Stephen V. Benson; Pavel Evtuschenko

    2007-08-02

    Free Electron Lasers (FEL) present a unique set of beam parameters to the diagnostics suite. The FEL requires characterization of the full six dimensional phase space of the electron beam at the wiggler and accurate alignment of the electron beam to the optical mode of the laser. In addition to the FEL requirements on the diagnostics suite, the Jefferson Lab FEL is operated as an Energy Recovered Linac (ERL) which imposes additional requirements on the diagnostics. The ERL aspect of the Jefferson Lab FEL requires that diagnostics operate over a unique dynamic range and operate with simultaneous transport of the accelerated and energy recovered beams. This talk will present how these challenges are addressed at the Jefferson Lab FEL.

  8. Saliva Preservative for Diagnostic Purposes

    Science.gov (United States)

    Pierson, Duane L.; Mehta, Satish K.

    2012-01-01

    Saliva is an important body fluid for diagnostic purposes. Glycoproteins, glucose, steroids, DNA, and other molecules of diagnostic value are found in saliva. It is easier to collect as compared to blood or urine. Unfortunately, saliva also contains large numbers of bacteria that can release enzymes, which can degrade proteins and nucleic acids. These degradative enzymes destroy or reduce saliva s diagnostic value. This innovation describes the formulation of a chemical preservative that prevents microbial growth and inactivates the degradative enzymes. This extends the time that saliva can be stored or transported without losing its diagnostic value. Multiple samples of saliva can be collected if needed without causing discomfort to the subject and it does not require any special facilities to handle after it is collected.

  9. High-precision optical measuring instruments and their application as part of mobile diagnostic complexes

    Directory of Open Access Journals (Sweden)

    Igor Miroshnichenko

    2014-04-01

    Full Text Available The article is devoted to the results of the laser technologies and methods of optical interferometry for registering information in the quality control and diagnostics of the construction materials and the power of elements of the acoustic non-destructive control, and also described new technical decisions, allowing to apply the results obtained to the solution of practical problems of diagnostics of products in operation, as part of mobile diagnostic complexes.

  10. Molecular diagnostics of myeloproliferative neoplasms

    DEFF Research Database (Denmark)

    Langabeer, S. E.; Andrikovics, H.; Asp, J.;

    2015-01-01

    identified. These discoveries have been rapidly incorporated into evolving molecular diagnostic algorithms. Whilst many of these mutations appear to have prognostic implications, establishing MPN diagnosis is of immediate clinical importance with selection, implementation and the continual evaluation...... of the appropriate laboratory methodology to achieve this diagnosis similarly vital. The advantages and limitations of these approaches in identifying and quantitating the common MPN-associated mutations are considered herein with particular regard to their clinical utility. The evolution of molecular diagnostic...

  11. Diagnostic indices for vertiginous diseases

    Directory of Open Access Journals (Sweden)

    Warninghoff Jan-Christian

    2010-10-01

    Full Text Available Abstract Background Vertigo and dizziness are symptoms which are reported frequently in clinical practice. We aimed to develop diagnostic indices for four prevalent vertiginous diseases: benign paroxysmal positional vertigo (BPPV, Menière's disease (MD, vestibular migraine (VM, and phobic postural vertigo (PPV. Methods Based on a detailed questionnaire handed out to consecutive patients presenting for the first time in our dizziness clinic we preselected a set of seven questions with desirable diagnostic properties when compared with the final diagnosis after medical workup. Using exact logistic regression analysis diagnostic scores, each comprising of four to six items that can simply be added up, were built for each of the four diagnoses. Results Of 193 patients 131 questionnaires were left after excluding those with missing consent or data. Applying the suggested cut-off points, sensitivity and specificity were 87.5 and 93.5% for BPPV, 100 and 87.4% for MD, 92.3 and 83.7% for VM, 73.7 and 84.1% for PPV, respectively. By changing the cut-off points sensitivity and specificity can be adjusted to meet diagnostic needs. Conclusions The diagnostic indices showed promising diagnostic properties. Once further validated, they could provide an ease to use and yet flexible tool for screening vertigo in clinical practice and epidemiological research.

  12. Research of deafness tinnitus rehabilitation instrument based on single chip microcomputer%基于单片机的耳聋耳鸣康复仪的研究

    Institute of Scientific and Technical Information of China (English)

    徐秋娜; 王佳丽; 陈付毅; 林晓蕾; 王琳斌; 顾晓雯; 张健

    2015-01-01

    It aims to design a kind of deafness and tinnitus rehabilitation instrument which is practical portable and widely applicated. In the treatment,single-chip has been added to control and help patients restore hearing and regain health. According to the electrical impedance specific of points, we design cave exploration circuit with adjustable threshold. Design waveform generator waveform to drive the headphone sound, to achieve frequency, continuously adjustable dB pure tone stimuli, LCD real-time display and record the hearing thresholds of patients. Take use of white noise to therapy, through transistor base-collector zener produce white noise, the intensity can be adjusted. Design biological pulse generating circuit, and after doubler circuit boosting spark will be similar to the feeling of acupuncture, acupuncture points on the human body for the treatment. Treatment intensity is displayed on LCD, and buttons control circuit output intensity. After a lot of experiments, the accuracy rate of Probe Points is up to 95%. Pure tone stimulus frequency and decibel satisfy the requirements of hearing threshold detection, the frequency is 20 Hz-20 kHz, dB 0~90 dB. Biological pulse stimulation intensity does not exceed the electric current of human security and safe voltage. It is practical and portable, and it is easy to operate. It is in line with contemporary trends of deafness and tinnitus rehabilitation instrument. Also it provides a good help to achieve effective rehabilitation of patients with tinnitus and deafness.%研究旨在设计一款实用便携、应用范围广的耳聋耳鸣康复仪,在功能上增加了单片机控制治疗强度,帮助患者恢复听力,重获健康。根据穴位的电阻抗特异性,设计阈值可调的探穴电路;设计波形发生器产生波形驱动耳机发声,实现频率、分贝连续可调的纯音刺激源,液晶实时显示并记录患者听阈值;采用白噪声治疗,通过三极管基极-集电极

  13. Stochastic Engine Convergence Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Glaser, R

    2001-12-11

    ;'burn-in'' period. The MCMC process begins at a particular state, which is selected at random or by design, according to the wish of the user of the engine. After the burn-in period, the chain has essentially forgotten where it started. Moreover, the sample x{sup (t{sub 0})}, x{sup (T{sub 0}+1)},... can be used for most purposes as a random sample from f, even though the x{sup (T{sub 0}+t)}, because of Markovian dependency, are not independent. For example, averages involving x{sup (t{sub 0})}, x{sup (t{sub 0}+1)},... may have an approximate normal distribution. The purpose of this note is to discuss the monitoring techniques currently in place in the stochastic engine software that addresses the issues of burn-in, stationarity, and normality. They are loosely termed ''convergence diagnostics'', in reference to the underlying Markov chains, which converge asymptotically to the desired posterior distribution.

  14. In-flight Diagnostics in LISA Pathfinder

    Science.gov (United States)

    Lobo, A.; Nofrarias, M.; Ramos-Castro, J.; Sanjuan, J.; Conchillo, A.; Ortega, J. A.; Xirgu, X.; Araujo, H.; Boatella, C.; Chmeissani, M.; Grimani, C.; Puigdengoles, C.; Wass, P.; García-Berro, E.; García, S.; Martínez, L. M.; Montero, G.

    2006-11-01

    LISA PathFinder (LPF) will be flown with the objective to test in space key technologies for LISA. However its sensitivity goals are, for good reason, one order of magnitude less than those which LISA will have to meet, both in drag-free and optical metrology requirements, and in the observation frequency band. While the expected success of LPF will of course be of itself a major step forward to LISA, one might not forget that a further improvement by an order of magnitude in performance will still be needed. Clues for the last leap are to be derived from proper disentanglement of the various sources of noise which contribute to the total noise, as measured in flight during the PathFinder mission. This paper describes the principles, workings and requirements of one of the key tools to serve the above objective: the diagnostics subsystem. This consists in sets of temperature, magnetic field, and particle counter sensors, together with generators of controlled thermal and magnetic perturbations. At least during the commissioning phase, the latter will be used to identify feed-through coefficients between diagnostics sensor readings and associated actual noise contributions. A brief progress report of the current state of development of the diagnostics subsystem will be given as well.

  15. Nanophotonics for Molecular Diagnostics and Therapy Applications

    Directory of Open Access Journals (Sweden)

    João Conde

    2012-01-01

    Full Text Available Light has always fascinated mankind and since the beginning of recorded history it has been both a subject of research and a tool for investigation of other phenomena. Today, with the advent of nanotechnology, the use of light has reached its own dimension where light-matter interactions take place at wavelength and subwavelength scales and where the physical/chemical nature of nanostructures controls the interactions. This is the field of nanophotonics which allows for the exploration and manipulation of light in and around nanostructures, single molecules, and molecular complexes. What is more is the use of nanophotonics in biomolecular interactions—nanobiophotonics—has prompt for a plethora of molecular diagnostics and therapeutics making use of the remarkable nanoscale properties. In this paper, we shall focus on the uses of nanobiophotonics for molecular diagnostics involving specific sequence characterization of nucleic acids and for gene delivery systems of relevance for therapy strategies. The use of nanobiophotonics for the combined diagnostics/therapeutics (theranostics will also be addressed, with particular focus on those systems enabling the development of safer, more efficient, and specific platforms. Finally, the translation of nanophotonics for theranostics into the clinical setting will be discussed.

  16. Ares I-X Ground Diagnostic Prototype

    Science.gov (United States)

    Schwabacher, Mark; Martin, Rodney; Waterman, Robert; Oostdyk, Rebecca; Ossenfort, John; Matthews, Bryan

    2010-01-01

    Automating prelaunch diagnostics for launch vehicles offers three potential benefits. First, it potentially improves safety by detecting faults that might otherwise have been missed so that they can be corrected before launch. Second, it potentially reduces launch delays by more quickly diagnosing the cause of anomalies that occur during prelaunch processing. Reducing launch delays will be critical to the success of NASA's planned future missions that require in-orbit rendezvous. Third, it potentially reduces costs by reducing both launch delays and the number of people needed to monitor the prelaunch process. NASA is currently developing the Ares I launch vehicle to bring the Orion capsule and its crew of four astronauts to low-earth orbit on their way to the moon. Ares I-X will be the first unmanned test flight of Ares I. It is scheduled to launch on October 27, 2009. The Ares I-X Ground Diagnostic Prototype is a prototype ground diagnostic system that will provide anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage thrust vector control (TVC) and for the associated ground hydraulics while it is in the Vehicle Assembly Building (VAB) at John F. Kennedy Space Center (KSC) and on the launch pad. It will serve as a prototype for a future operational ground diagnostic system for Ares I. The prototype combines three existing diagnostic tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool that is commercially produced by Qualtech Systems, Inc. It uses a qualitative model of failure propagation to perform fault isolation and diagnostics. We adapted an existing TEAMS model of the TVC to use for diagnostics and developed a TEAMS model of the ground hydraulics. The second tool, Spacecraft Health Inference Engine (SHINE), is a rule-based expert system developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification. The prototype

  17. Comparative diagnostic techniques for cryptosporidium infection.

    Science.gov (United States)

    Omoruyi, Beauty E; Nwodo, Uchechukwu U; Udem, Chukwuneke S; Okonkwo, Francis O

    2014-02-24

    Diarrhoea caused by Cryptosporidium is usually mild in immune competent individuals but severe in the young and those with underlying disease leading to compromised immunity. The conventional diagnosis of Cryptosporidium requires observation of the infective oocysts however, their tiny size yields indistinct results, thus limiting the effectiveness of the conventional diagnostic technique, modified Ziehl-Neelsen (ZN) differential staining. Consequent to the abovementioned limitation, ZN staining, sandwich antigen detection enzyme linked immunosorbent assay (sad-ELISA) and a direct polymerase chain reaction (PCR) assay techniques were evaluated for diagnostic efficacy. Stool samples were collected from 180 consenting adult patients attending outpatient and inpatient clinics at Victoria Hospital, Alice, Eastern Cape Province of South Africa. Subjects were stratified as; 35 HIV-positive and diarrhoeagenic, 125 HIV-negative diarrhoeagenic and 20 apparently healthy controls. Cryptosporidium incidence following diagnostic techniques were 13 (37.1%; ZN staining), 26 (74.3%; sad-ELISA) and 23 (65.7%; PCR), respectively, among HIV-positive diarrhoeagenic patients and 34 (27.2%; ZN staining), 96 (76.8%; sad-ELISA) and 89 (71.2%; PCR) among HIV-negative diarrhoeagenic patients. Sensitivity, specificity and predictive values of the diagnostic techniques' efficiency were: sensitivity: 46.2% (HIV-positive) and 32.3% (HIV-negative) against the ZN technique and 96.9% against sad-ELISA and PCR, respectively, for both HIV-positive and -negative patients; specificity was 88.9% (HIV-positive) and 96.6% (HIV-negative) against the ZN technique. Lastly, the predictive values were 92.3% (HIV-positive) and 96.9% (HIV-negative), respectively, following ZN staining. The sad-ELISA technique proved more suitable for the determination of the presence of Cryptosporidium oocysts. The high incidence of Cryptosporidium in HIV-positive subjects as compared to the HIV-negative population accentuates

  18. Comparative Diagnostic Techniques for Cryptosporidium Infection

    Directory of Open Access Journals (Sweden)

    Beauty E. Omoruyi

    2014-02-01

    Full Text Available Diarrhoea caused by Cryptosporidium is usually mild in immune competent individuals but severe in the young and those with underlying disease leading to compromised immunity. The conventional diagnosis of Cryptosporidium requires observation of the infective oocysts however, their tiny size yields indistinct results, thus limiting the effectiveness of the conventional diagnostic technique, modified Ziehl-Neelsen (ZN differential staining. Consequent to the abovementioned limitation, ZN staining, sandwich antigen detection enzyme linked immunosorbent assay (sad-ELISA and a direct polymerase chain reaction (PCR assay techniques were evaluated for diagnostic efficacy. Stool samples were collected from 180 consenting adult patients attending outpatient and inpatient clinics at Victoria Hospital, Alice, Eastern Cape Province of South Africa. Subjects were stratified as; 35 HIV-positive and diarrhoeagenic, 125 HIV-negative diarrhoeagenic and 20 apparently healthy controls. Cryptosporidium incidence following diagnostic techniques were 13 (37.1%; ZN staining, 26 (74.3%; sad-ELISA and 23 (65.7%; PCR, respectively, among HIV-positive diarrhoeagenic patients and 34 (27.2%; ZN staining, 96 (76.8%; sad-ELISA and 89 (71.2%; PCR among HIV-negative diarrhoeagenic patients. Sensitivity, specificity and predictive values of the diagnostic techniques’ efficiency were: sensitivity: 46.2% (HIV-positive and 32.3% (HIV-negative against the ZN technique and 96.9% against sad-ELISA and PCR, respectively, for both HIV-positive and -negative patients; specificity was 88.9% (HIV-positive and 96.6% (HIV-negative against the ZN technique. Lastly, the predictive values were 92.3% (HIV-positive and 96.9% (HIV-negative, respectively, following ZN staining. The sad-ELISA technique proved more suitable for the determination of the presence of Cryptosporidium oocysts. The high incidence of Cryptosporidium in HIV-positive subjects as compared to the HIV-negative population

  19. Immunochromatographic diagnostic test analysis using Google Glass.

    Science.gov (United States)

    Feng, Steve; Caire, Romain; Cortazar, Bingen; Turan, Mehmet; Wong, Andrew; Ozcan, Aydogan

    2014-03-25

    We demonstrate a Google Glass-based rapid diagnostic test (RDT) reader platform capable of qualitative and quantitative measurements of various lateral flow immunochromatographic assays and similar biomedical diagnostics tests. Using a custom-written Glass application and without any external hardware attachments, one or more RDTs labeled with Quick Response (QR) code identifiers are simultaneously imaged using the built-in camera of the Google Glass that is based on a hands-free and voice-controlled interface and digitally transmitted to a server for digital processing. The acquired JPEG images are automatically processed to locate all the RDTs and, for each RDT, to produce a quantitative diagnostic result, which is returned to the Google Glass (i.e., the user) and also stored on a central server along with the RDT image, QR code, and other related information (e.g., demographic data). The same server also provides a dynamic spatiotemporal map and real-time statistics for uploaded RDT results accessible through Internet browsers. We tested this Google Glass-based diagnostic platform using qualitative (i.e., yes/no) human immunodeficiency virus (HIV) and quantitative prostate-specific antigen (PSA) tests. For the quantitative RDTs, we measured activated tests at various concentrations ranging from 0 to 200 ng/mL for free and total PSA. This wearable RDT reader platform running on Google Glass combines a hands-free sensing and image capture interface with powerful servers running our custom image processing codes, and it can be quite useful for real-time spatiotemporal tracking of various diseases and personal medical conditions, providing a valuable tool for epidemiology and mobile health.

  20. Nuclear technology aspects of ITER vessel-mounted diagnostics

    Science.gov (United States)

    Vayakis, George; Bertalot, Luciano; Encheva, Anna; Walker, Chris; Brichard, Benoît; Cheon, M. S.; Chitarin, G.; Hodgson, Eric; Ingesson, Christian; Ishikawa, M.; Kondoh, T.; Meister, Hans; Moreau, Philippe; Peruzzo, Simone; Pak, S.; Pérez-Pichel, Germán; Reichle, Roger; Testa, Duccio; Toussaint, Matthieu; Vermeeren, Ludo; Vershkov, Vladimir

    2011-10-01

    ITER has diagnostics with machine protection, basic and advanced control, and physics roles. Several are distributed on the inner and outer periphery of the vacuum vessel. They have reduced maintainability compared to diagnostics in ports. They also endure some of the highest nuclear and EM loads of any diagnostic for the longest time. They include: Inductive sensors for time-integrated and raw inductive measurements; Steady-state magnetic sensors to correct drifts of the inductive sensors; Bolometer cameras to provide electromagnetic radiation tomography; Microfission chambers and neutron activation stations to provide fusion power and fluence; MM-wave reflectometry to measure the plasma density profile and the plasma-wall distance and; Wiring to service magnetics, bolometry, and in-vessel instrumentation. This paper summarises the key technological issues these diagnostics arising from the nuclear environment, recent progress and outstanding R&D for each system.

  1. Far infrared fusion plasma diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Luhmann, N.C. Jr.; Peebles, W.A.

    1990-01-01

    Over the last several years, reflectometry has grown in importance as a diagnostic for both steady-state density Profiles as well as for the investigation of density fluctuations and turbulence. As a diagnostic for density profile measurement, it is generally believed to be well understood in the tokamak environment. However, its use as a fluctuation diagnostic is hampered by a lack of quantitative experimental understanding of its wavenumber sensitivity and spatial resolution. Several researchers, have theoretically investigated these questions. However, prior to the UCLA laboratory investigation, no group has experimentally investigated these questions. Because of the reflectometer's importance to the world effort in understanding plasma turbulence and transport, UCLA has, over the last year, made its primary Task IIIA effort the resolution of these questions. UCLA has taken the lead in a quantitative experimental understanding of reflectometer data as applied to the measurement of density fluctuations. In addition to this, work has proceeded on the design, construction, and installation of a reflectometer system on UCLA's CCT tokamak. This effort will allow a comparison between the improved confinement regimes (H-mode) observed on both the DIII-D and CCT machines with the goal of achieving a physics understanding of the phenomena. Preliminary investigation of a new diagnostic technique to measure density profiles as a function of time has been initiated at UCLA. The technique promises to be a valuable addition to the range of available plasma diagnostics. Work on advanced holographic reflectometry technique as applied to fluctuation diagnostics has awaited a better understanding of the reflectometer signal itself as discussed above. Efforts to ensure the transfer of the diagnostic developments have continued with particular attention devoted to the preliminary design of a multichannel FIR interferometer for MST.

  2. Gastrointestinal Amyloidosis: Diagnostic Approach and Treatment

    Directory of Open Access Journals (Sweden)

    Catarina Budyono

    2015-12-01

    Full Text Available Amyloidosis is a disease marked by deposition of misfolded proteins, known as amyloids, in the extracellular space, including gastrointestinal tract. According to the precursor protein, amyloidosis is classified into six types; all of which can be involved in the gastrointestinal tract. Amyloidosis has weight loss and gastrointestinal bleeding as the most frequent symptoms. Gastrointestinal tract biopsy is diagnostic in most cases of amyloidosis and Congo red stain is used to confirm the amyloid proteins deposit. Treatment of amyloidosis consists of controlling symptoms, terminating protein formation and deposit, and treating the underlying diseases. Chemotherapy might be applied depends on the type of amyloidosis.

  3. Microarray Technologies in Fungal Diagnostics.

    Science.gov (United States)

    Rupp, Steffen

    2017-01-01

    Microarray technologies have been a major research tool in the last decades. In addition they have been introduced into several fields of diagnostics including diagnostics of infectious diseases. Microarrays are highly parallelized assay systems that initially were developed for multiparametric nucleic acid detection. From there on they rapidly developed towards a tool for the detection of all kind of biological compounds (DNA, RNA, proteins, cells, nucleic acids, carbohydrates, etc.) or their modifications (methylation, phosphorylation, etc.). The combination of closed-tube systems and lab on chip devices with microarrays further enabled a higher automation degree with a reduced contamination risk. Microarray-based diagnostic applications currently complement and may in the future replace classical methods in clinical microbiology like blood cultures, resistance determination, microscopic and metabolic analyses as well as biochemical or immunohistochemical assays. In addition, novel diagnostic markers appear, like noncoding RNAs and miRNAs providing additional room for novel nucleic acid based biomarkers. Here I focus an microarray technologies in diagnostics and as research tools, based on nucleic acid-based arrays.

  4. Diagnostic vitrectomy for infectious uveitis

    Science.gov (United States)

    Jeroudi, Abdallah; Yeh, Steven

    2014-01-01

    The identification of an infectious or noninfectious uveitis syndrome is important to determine the range of therapeutic and prognostic implications of that disease entity. Diagnostic dilemmas arise with atypical history, atypical clinical presentations, inconclusive diagnostic workup, and persistent or worsened inflammation despite appropriate immunosuppression. More invasive intraocular testing is indicated in these situations particularly in infectious uveitis where a delay in treatment may result in worsening of the patient’s disease and a poor visual outcome. Laboratory analysis of vitreous fluid via diagnostic pars plana vitrectomy is an important technique in the diagnostic armamentarium, but the most important aspects of sample collection include rapid processing, close coordination with an ophthalmic pathology laboratory, and directed testing on this limited collected sample. Culture and staining has utility in bacterial, fungal, and nocardial infection. Polymerase chain reaction (PCR) analysis has shown promising results for bacterial endophthalmitis and infection with mycobacterium tuberculosis whereas PCR testing for viral retinitides and ocular toxoplasmosis has a more established role. Antibody testing is appropriate for toxoplasmosis and toxocariasis, and may be complementary to PCR for viral retinitis. Masquerade syndromes represent neoplastic conditions that clinically appear as infectious or inflammatory conditions and should be considered as part of the differential diagnosis. Diagnostic vitrectomy and chorioretinal biopsy are thus critical tools for the management of patients in whom an infectious etiology of uveitis is suspected. PMID:24613892

  5. Diagnostics for the ATA beam propagation experiments

    Energy Technology Data Exchange (ETDEWEB)

    Fessenden, T.J.; Atchison, W.L.; Barletta, W.A.

    1981-11-01

    This report contains a discussion of the diagnostics required for the beam propagation experiment to be done with the ATA accelerator. Included are a list of the diagnostics needed; a description of the ATA experimental environment; the status of beam diagnostics available at Livermore including recent developments, and a prioritized list of accelerator and propagation diagnostics under consideration or in various stages of development.

  6. Optical diagnostics of intermittent flows

    DEFF Research Database (Denmark)

    Okulov, V.L.; Naumov, I.V.; Sørensen, Jens Nørkær

    2007-01-01

    The efficiency of combined use of different optical techniques for flow diagnostics is demonstrated with the practically important case of intense swirling flows. It is shown that, when applied separately, commonly used optical measuring techniques, such as laser Doppler anemometry and particle...... image velocimetry, frequently give erroneous results, especially for the transition flow and developed nonstationary flow. However, their combined use in diagnostics of unsteady (intermittent) flows significantly improves both the temporal and spatial resolution of measurements. Such a complex approach...... is for the first time applied for diagnostics of the flow pattern in a closed cylinder with a rotating end face with the aim of studying the changeover from the steady axisymmetric to unsteady asymmetric flow over a wide range of flow parameters. It is found that such a transition is notable for azimuthal...

  7. Enhanced NIF neutron activation diagnostics.

    Science.gov (United States)

    Yeamans, C B; Bleuel, D L; Bernstein, L A

    2012-10-01

    The NIF neutron activation diagnostic suite relies on removable activation samples, leading to operational inefficiencies and a fundamental lower limit on the half-life of the activated product that can be observed. A neutron diagnostic system measuring activation of permanently installed samples could remove these limitations and significantly enhance overall neutron diagnostic capabilities. The physics and engineering aspects of two proposed systems are considered: one measuring the (89)Zr/(89 m)Zr isomer ratio in the existing Zr activation medium and the other using potassium zirconate as the activation medium. Both proposed systems could improve the signal-to-noise ratio of the current system by at least a factor of 5 and would allow independent measurement of fusion core velocity and fuel areal density.

  8. Molecular diagnostics of neurodegenerative disorders

    Directory of Open Access Journals (Sweden)

    Megha eAgrawal

    2015-09-01

    Full Text Available Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer’s and Parkinson’s disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and Huntington’s disease, and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.

  9. A Diagnostic Approach to Hemochromatosis

    Directory of Open Access Journals (Sweden)

    Anthony S Tavill

    2006-01-01

    Full Text Available In the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expression of disease and the utility of biochemical iron tests for the detection of disease and for the assessment of disease severity. Liver biopsy has become more of a prognostic test than a diagnostic test. The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis.

  10. Audiologic diagnostics of vestibular schwannoma

    Directory of Open Access Journals (Sweden)

    Komazec Zoran

    2004-01-01

    Full Text Available Introduction Vestibular schwannoma (acoustic neuroma is a rare, but important cause of sensorineural hearing loss. Patients with asymmetric hearing loss, or unilateral tinnitus should be evaluated expeditiously, to prevent further neurological damage. Audiologic diagnostics Audiologic diagnostics represents the basic diagnosis for early detection of vestibular schwannoma. Patients with vestibular schwannomas may present with a variety of clinical features, including retrocochlear pattern of sensorineural hearing loss. Supraliminary audiometry, tympano- metry, stapedius reflex and otoacoustic emissions as well as vestibular response to caloric testing are methods for selection of patients with suspicion of this tumor. Conclusion The golden standard for audiologic diagnostics of vestibular schwannoma is BAEP (Brainstem Auditory Evoked Potentials. Patients with pathological findings of BAEP should undergo MRI of the posterior fossa. Gadolinium-enhanced magnetic resonance imaging is the best and final tool for making a diagnosis of vestibular schwannoma.

  11. Diagnostic accuracy in virtual dermatopathology

    DEFF Research Database (Denmark)

    Mooney, E.; Kempf, W.; Jemec, G.B.E.;

    2012-01-01

    Background Virtual microscopy is used for teaching medical students and residents and for in-training and certification examinations in the United States. However, no existing studies compare diagnostic accuracy using virtual slides and photomicrographs. The objective of this study was to compare...... slides and photomicrographs with corresponding clinical photographs and information in a self-assessment examination format. Descriptive data analysis and comparison of groups were performed using a chi-square test. Results Diagnostic accuracy in dermatopathology using virtual dermatopathology...... represented a useful tool for learning; 90% felt that virtual dermatopathology is useful tool for teaching dermatopathology. Conclusion No significant difference was observed in diagnostic accuracy using virtual dermatopathology compared to photomicrographs. Most participants felt virtual dermatopathology...

  12. [Hypernatremia - Diagnostics and therapy].

    Science.gov (United States)

    Arndt, Christian; Wulf, Hinnerk

    2016-05-01

    Hypernatremia is a common electrolyte disorder that reflects an imbalance in the water balance of the body, often resulting from an increased loss of free water compared to sodium excretion. It is rarely based on excessive sodium intake. The clinical presentation is often characterized by a central nervous system dysfunction (confusion, coma) and pronounced thirst (in awake patients). In addition to medical history, the volume status of the patient and the osmolality of urine are leading in the differential diagnosis. Usually, the treatment of hypernatremia - in addition to addressing the underlying cause - is replacing the (absolute or relative) loss of free water by hypotonic infusions, or in case of diabetes insipidus, by application of Desmopressin (Minirin). As rapid changes in serum sodium concentration may have deleterious consequences (osmotic demyelinsiation syndrome), preexisting hypernatremia (>48h) should not be reduced by more than 8-10 mmol/l/day. Close laboratory controls are important. For acute hypernatremia (< 24 hours), hemodialysis is an effective option to rapidly normalize the serum sodium levels. To avoid a rapid drop in sodium concentration that must also be considered when starting a renal replacement therapy in patients with chronic hypernatremia.

  13. Diagnostic testing and educational assessment.

    Science.gov (United States)

    Tweed, Mike; Wilkinson, Tim

    2012-10-01

    Clinicians are familiar with making diagnostic decisions based on information gathered from history, clinical examination and diagnostic tests. Although many clinicians assess students, they may be less familiar with ways to assimilate assessment information to inform educational decisions. We draw parallels between the processes used to make a clinical diagnosis and the similar processes needed to make an educational decision. There are several indices that describe the performance and utility of diagnostic tests, which we have extrapolated to educational assessment. We provide a clinical diagnostic question and an education assessment question, and use examples of indices of performance and utility for both of these situations to explore: reliability, indeterminate results, certainty in decisions, acceptable levels of sensitivity and specificity, pre-test probability and dealing with limitations. Test reliability requires adequate sampling and consistency between observers. Seeking more information should be targeted to situations where decisions are not certain. Altering score cut-points alters test sensitivity and specificity, which in assessment will alter the numbers of falsely passing or falsely failing candidates. Just as the pre-test probability of a diagnosis influences how to interpret diagnostic tests, so too does the pre-test probability of failure alter the performance characteristics of assessments. In clinical situations, a 'wait and see' approach may be limited by clinical urgency. Likewise, in assessment the 'wait and see' approach may be limited by a duty to society. Clinicians familiar with the performance and utility of diagnostic tests can extrapolate that knowledge to make better interpretations of educational assessments. © Blackwell Publishing Ltd 2012.

  14. Imaging Techniques for Microwave Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Donne, T. [FOM-Institute for Plasma Physics Rijnhuizen, Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Luhmann Jr, N.C. [University of California, Davis, CA 95616 (United States); Park, H.K. [POSTECH, Pohang, Gyeongbuk 790-784 (Korea, Republic of); Tobias, B.

    2011-07-01

    Advances in microwave technology have made it possible to develop a new generation of microwave imaging diagnostics for measuring the parameters of magnetic fusion devices. The most prominent of these diagnostics is electron cyclotron emission imaging (ECE-I). After the first generation of ECE-I diagnostics utilized at the TEXT-U, RTP and TEXTOR tokamaks and the LHD stellarator, new systems have recently come into operation on ASDEX-UG and DIII-D, soon to be followed by a system on KSTAR. The DIII-D and KSTAR systems feature dual imaging arrays that observe different parts of the plasma. The ECE-I diagnostic yields two-dimensional movies of the electron temperature in the plasma and has given already new insights into the physics of sawtooth oscillations, tearing modes and edge localized modes. Microwave Imaging Reflectometry (MIR) is used on LHD to measure electron density fluctuations. A pilot MIR system has been tested at TEXTOR and, based on the promising results, a new system is now under design for KSTAR. The system at TEXTOR was used to measure the plasma rotation velocity. The system at KSTAR and also the one on LHD will be/are used for measuring the profile of the electron density fluctuations in the plasma. Other microwave imaging diagnostics are phase imaging interferometry, and imaging microwave scattering. The emphasis in this paper will be largely focused on ECE-I. First an overview of the advances in microwave technology are discussed, followed by a description of a typical ECE-I system along with some typical experimental results. Also the utilization of imaging techniques in other types of microwave diagnostics will be briefly reviewed. This document is composed of the slides of the presentation. (authors)

  15. Diagnostic imaging in bovine orthopedics.

    Science.gov (United States)

    Kofler, Johann; Geissbühler, Urs; Steiner, Adrian

    2014-03-01

    Although a radiographic unit is not standard equipment for bovine practitioners in hospital or field situations, ultrasound machines with 7.5-MHz linear transducers have been used in bovine reproduction for many years, and are eminently suitable for evaluation of orthopedic disorders. The goal of this article is to encourage veterinarians to use radiology and ultrasonography for the evaluation of bovine orthopedic disorders. These diagnostic imaging techniques improve the likelihood of a definitive diagnosis in every bovine patient but especially in highly valuable cattle, whose owners demand increasingly more diagnostic and surgical interventions that require high-level specialized techniques.

  16. Diagnostic nerve ultrasonography; Diagnostische Nervensonographie

    Energy Technology Data Exchange (ETDEWEB)

    Baeumer, T. [Universitaet zu Luebeck CBBM, Haus 66, Institut fuer Neurogenetik, Luebeck (Germany); Grimm, A. [Universitaetsklinikum Tuebingen, Klinik und Poliklinik fuer Neurologie, Tuebingen (Germany); Schelle, T. [Staedtisches Klinikum Dessau, Neurologische Klinik, Dessau (Germany)

    2017-03-15

    For the diagnostics of nerve lesions an imaging method is necessary to visualize peripheral nerves and their surrounding structures for an etiological classification. Clinical neurological and electrophysiological investigations provide functional information about nerve lesions. The information provided by a standard magnetic resonance imaging (MRI) examination is inadequate for peripheral nerve diagnostics; however, MRI neurography is suitable but on the other hand a resource and time-consuming method. Using ultrasonography for peripheral nerve diagnostics. With ultrasonography reliable diagnostics of entrapment neuropathies and traumatic nerve lesions are possible. The use of ultrasonography for neuropathies shows that a differentiation between different forms is possible. Nerve ultrasonography is an established diagnostic tool. In addition to the clinical examination and clinical electrophysiology, structural information can be obtained, which results in a clear improvement in the diagnostics. Ultrasonography has become an integral part of the diagnostic work-up of peripheral nerve lesions in neurophysiological departments. Nerve ultrasonography is recommended for the diagnostic work-up of peripheral nerve lesions in addition to clinical and electrophysiological investigations. It should be used in the clinical work-up of entrapment neuropathies, traumatic nerve lesions and spacy-occupying lesions of nerves. (orig.) [German] Fuer die Diagnostik von Nervenlaesionen ist ein bildgebendes Verfahren zur Darstellung des peripheren Nervs und seiner ihn umgebenden Strukturen fuer eine aetiologische Einordnung erforderlich. Mit der klinisch-neurologischen Untersuchung und Elektrophysiologie ist eine funktionelle Aussage ueber die Nervenlaesion moeglich. In der Standard-MRT-Untersuchung wird der periphere Nerv nur unzureichend gut dargestellt. Die MRT-Neurographie ist ein sehr gutes, aber auch zeit- und ressourcenintensives Verfahren. Nutzung des Ultraschalls fuer die

  17. First Wall and Operational Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Lasnier, C; Allen, S; Boedo, J; Groth, M; Brooks, N; McLean, A; LaBombard, B; Sharpe, J; Skinner, C; Whyte, D; Rudakov, D; West, W; Wong, C

    2006-06-19

    In this chapter we review numerous diagnostics capable of measurements at or near the first wall, many of which contribute information useful for safe operation of a tokamak. There are sections discussing infrared cameras, visible and VUV cameras, pressure gauges and RGAs, Langmuir probes, thermocouples, and erosion and deposition measurements by insertable probes and quartz microbalance. Also discussed are dust measurements by electrostatic detectors, laser scattering, visible and IR cameras, and manual collection of samples after machine opening. In each case the diagnostic is discussed with a view toward application to a burning plasma machine such as ITER.

  18. Diagnostic testing for Giardia infections.

    Science.gov (United States)

    Heyworth, Martin F

    2014-03-01

    The traditional method for diagnosing Giardia infections involves microscopic examination of faecal specimens for Giardia cysts. This method is subjective and relies on observer experience. From the 1980s onwards, objective techniques have been developed for diagnosing Giardia infections, and are superseding diagnostic techniques reliant on microscopy. Detection of Giardia antigen(s) by immunoassay is the basis of commercially available diagnostic kits. Various nucleic acid amplification techniques (NAATs) can demonstrate DNA of Giardia intestinalis, and have the potential to become standard approaches for diagnosing Giardia infections. Of such techniques, methods involving either fluorescent microspheres (Luminex) or isothermal amplification of DNA (loop-mediated isothermal amplification; LAMP) are especially promising.

  19. [The diagnostic possibilities of saliva].

    Science.gov (United States)

    Kochurova, E V; Kozlov, S V

    2014-01-01

    Saliva is a clinically informative biological fluid which contains multitude of bio-markers. This characteristic makes it possible to carry out numerous analyzes for developing mode to test patient in situ, express-tests included. The diagnostic by saliva is a new area of more simple application both markers and analyzers that can be useful in diagnostic of diseases of oral cavity, oncological diseases included. The using of saliva expands perspectives for making clinical diagnosis and establishment of dynamics and monitoring of disease.

  20. Scabies: Prevention and Control

    Science.gov (United States)

    ... Diagnostic Assistance [DPDx] Error processing SSI file Prevention & Control Recommend on Facebook Tweet Share Compartir When a ... avoid outbreaks. Institutional outbreaks can be difficult to control and require a rapid, aggressive, and sustained response. ...

  1. Preliminary consideration of CFETR ITER-like case diagnostic system.

    Science.gov (United States)

    Li, G S; Yang, Y; Wang, Y M; Ming, T F; Han, X; Liu, S C; Wang, E H; Liu, Y K; Yang, W J; Li, G Q; Hu, Q S; Gao, X

    2016-11-01

    Chinese Fusion Engineering Test Reactor (CFETR) is a new superconducting tokamak device being designed in China, which aims at bridging the gap between ITER and DEMO, where DEMO is a tokamak demonstration fusion reactor. Two diagnostic cases, ITER-like case and towards DEMO case, have been considered for CFETR early and later operating phases, respectively. In this paper, some preliminary consideration of ITER-like case will be presented. Based on ITER diagnostic system, three versions of increased complexity and coverage of the ITER-like case diagnostic system have been developed with different goals and functions. Version A aims only machine protection and basic control. Both of version B and version C are mainly for machine protection, basic and advanced control, but version C has an increased level of redundancy necessary for improved measurements capability. The performance of these versions and needed R&D work are outlined.

  2. Diagnostic accuracy of the Eurotest for dementia: a naturalistic, multicenter phase II study

    Directory of Open Access Journals (Sweden)

    Frank Ana

    2006-04-01

    Full Text Available Abstract Background Available screening tests for dementia are of limited usefulness because they are influenced by the patient's culture and educational level. The Eurotest, an instrument based on the knowledge and handling of money, was designed to overcome these limitations. The objective of this study was to evaluate the diagnostic accuracy of the Eurotest in identifying dementia in customary clinical practice. Methods A cross-sectional, multi-center, naturalistic phase II study was conducted. The Eurotest was administered to consecutive patients, older than 60 years, in general neurology clinics. The patients' condition was classified as dementia or no dementia according to DSM-IV diagnostic criteria. We calculated sensitivity (Sn, specificity (Sp and area under the ROC curves (aROC with 95% confidence intervals. The influence of social and educational factors on scores was evaluated with multiple linear regression analysis, and the influence of these factors on diagnostic accuracy was evaluated with logistic regression. Results Sixteen neurologists recruited a total of 516 participants: 101 with dementia, 380 without dementia, and 35 who were excluded. Of the 481 participants who took the Eurotest, 38.7% were totally or functionally illiterate and 45.5% had received no formal education. Mean time needed to administer the test was 8.2+/-2.0 minutes. The best cut-off point was 20/21, with Sn = 0.91 (0.84–0.96, Sp = 0.82 (0.77–0.85, and aROC = 0.93 (0.91–0.95. Neither the scores on the Eurotest nor its diagnostic accuracy were influenced by social or educational factors. Conclusion This naturalistic and pragmatic study shows that the Eurotest is a rapid, simple and useful screening instrument, which is free from educational influences, and has appropriate internal and external validity.

  3. Immunosensors in Clinical Laboratory Diagnostics.

    Science.gov (United States)

    Justino, Celine I L; Duarte, Armando C; Rocha-Santos, Teresa A P

    2016-01-01

    The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specificity and potential for application on real samples. The role of nanotechnology in the construction of immunological biosensors, that is, immunosensors, has contributed to the improvement of sensitivity, since they are based in the affinity between antibody and antigen. Other analytes than biomarkers such as hormones, pathogenic bacteria, and virus have also been detected by immunosensors for clinical point-of-care applications. In this chapter, we first introduced the various types of immunosensors and discussed their applications in clinical diagnostics over the recent 6 years, mainly as point-of-care technologies for the determination of cardiac and cancer biomarkers, hormones, pathogenic bacteria, and virus. The future perspectives of these devices in the field of clinical diagnostics are also evaluated.

  4. Diagnostic errors in pediatric radiology

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, George A.; Voss, Stephan D. [Children' s Hospital Boston, Department of Radiology, Harvard Medical School, Boston, MA (United States); Melvin, Patrice R. [Children' s Hospital Boston, The Program for Patient Safety and Quality, Boston, MA (United States); Graham, Dionne A. [Children' s Hospital Boston, The Program for Patient Safety and Quality, Boston, MA (United States); Harvard Medical School, The Department of Pediatrics, Boston, MA (United States)

    2011-03-15

    Little information is known about the frequency, types and causes of diagnostic errors in imaging children. Our goals were to describe the patterns and potential etiologies of diagnostic error in our subspecialty. We reviewed 265 cases with clinically significant diagnostic errors identified during a 10-year period. Errors were defined as a diagnosis that was delayed, wrong or missed; they were classified as perceptual, cognitive, system-related or unavoidable; and they were evaluated by imaging modality and level of training of the physician involved. We identified 484 specific errors in the 265 cases reviewed (mean:1.8 errors/case). Most discrepancies involved staff (45.5%). Two hundred fifty-eight individual cognitive errors were identified in 151 cases (mean = 1.7 errors/case). Of these, 83 cases (55%) had additional perceptual or system-related errors. One hundred sixty-five perceptual errors were identified in 165 cases. Of these, 68 cases (41%) also had cognitive or system-related errors. Fifty-four system-related errors were identified in 46 cases (mean = 1.2 errors/case) of which all were multi-factorial. Seven cases were unavoidable. Our study defines a taxonomy of diagnostic errors in a large academic pediatric radiology practice and suggests that most are multi-factorial in etiology. Further study is needed to define effective strategies for improvement. (orig.)

  5. Cognitive Diagnostic Modeling Using R

    Science.gov (United States)

    Ravand, Hamdollah

    2015-01-01

    Cognitive diagnostic models (CDM) have been around for more than a decade but their application is far from widespread for mainly two reasons: (1) CDMs are novel, as compared to traditional IRT models. Consequently, many researchers lack familiarity with them and their properties, and (2) Software programs doing CDMs have been expensive and not…

  6. Electronic DNA detection and diagnostics

    NARCIS (Netherlands)

    De, Arpita

    2013-01-01

    The Nanopill project is an ambitious undertaking with the objective to develop an early-warning cancer diagnostic pill that is ingested by the patient. The Nanopill collects intestinal fluid as the pill travels down the intestinal tract, and tests for the presence of a free floating hyper-methylated

  7. Local Sensitivity and Diagnostic Tests

    NARCIS (Netherlands)

    Magnus, J.R.; Vasnev, A.L.

    2004-01-01

    In this paper we confront sensitivity analysis with diagnostic testing.Every model is misspecified, but a model is useful if the parameters of interest (the focus) are not sensitive to small perturbations in the underlying assumptions. The study of the e ect of these violations on the focus is calle

  8. Diagnostic Ultrasound in Gynecologic Diagnosis

    OpenAIRE

    Coates, C. F.

    1983-01-01

    Diagnostic ultrasound is helpful in the assessment of many common gynecological conditions from early teens to the late postmenopause. Female pelvic anatomy and pathology are readily imaged through a distended urinary bladder. In gynecologic cancer, examination of peritoneal cavity, kidneys and liver can suggest metastatic spread, which aids tumor staging.

  9. Diagnostic Criteria for Pediatric MS

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2013-06-01

    Full Text Available Investigators at Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago review the diagnostic criteria for pediatric multiple sclerosis, the differential diagnosis, the 2010 McDonald criteria, and Callen criteria.

  10. When Diagnostic Labels Mask Trauma

    Science.gov (United States)

    Foltz, Robert; Dang, Sidney; Daniels, Brian; Doyle, Hillary; McFee, Scott; Quisenberry, Carolyn

    2013-01-01

    A growing body of research shows that many seriously troubled children and adolescents are reacting to adverse life experiences. Yet traditional diagnostic labels are based on checklists of surface symptoms. Distracted by disruptive behavior, the common response is to medicate, punish, or exclude rather than respond to needs of youth who have…

  11. Laser Diagnostics for Reacting Flows

    Science.gov (United States)

    2010-01-11

    absorption diagnostic for vapor-phase measurements in an evaporating n-decane aerosol,” Appied Physics B. 97, 215-225, (2009). 30. J.M. Porter, J.B...fluorescence of toluene for time- resolved imaging of gaseous flows,” Appied Physics B, 2010, in press. 35. J.M. Porter, J.B. Jeffries and R.K. Hanson

  12. Diagnostic discrepancies in clinical practice

    Science.gov (United States)

    Issa, Victor Sarli; Dinardi, Layara Fernanda Lipari; Pereira, Thiago Vicente; de Almeida, Lyna Kyria Rodrigues; Barbosa, Thaisa Silveira; Benvenutti, Luiz Alberto; Ayub-Ferreira, Silvia Moreira; Bocchi, Edimar Alcides

    2017-01-01

    Abstract Autopsies are the gold standard for diagnostic accuracy; however, no recent study has analyzed autopsies in heart failure (HF). We reviewed 1241 autopsies (January 2000–May 2005) and selected 232 patients with HF. Clinical and autopsy diagnoses were analyzed and discrepancies categorized according to their importance regarding therapy and prognosis. Mean age was 63.3 ± 15.9 years; 154 (66.4%) patients were male. The causes of death at autopsy were end-stage HF (40.9%), acute myocardial infarction (17.2%), infection (15.9), and pulmonary embolism 36 (15.5). Diagnostic discrepancies occurred in 191 (82.3%) cases; in 56 (24.1%), discrepancies were related to major diagnoses with potential influence on survival or treatment; pulmonary embolism was the cause of death for 24 (42.9%) of these patients. In 35 (15.1%), discrepancies were related to a major diagnosis with equivocal influence on survival or treatment; in 100 (43.1%), discrepancies did not influence survival or treatment. In multivariate analysis, age (OR: 1.03, 95% CI: 1.008–1.052, P = 0.007) and presence of diabetes mellitus (OR: 0.359, 95% CI: 0.168–0.767, P = 0.008) influenced the occurrence discrepancies. Diagnostic discrepancies with a potential impact on prognosis are frequent in HF. These findings warrant reconsideration in diagnostic and therapeutic practices with HF patients. PMID:28121951

  13. Droplet Microfluidics for Chip-Based Diagnostics

    Directory of Open Access Journals (Sweden)

    Karan V. I. S. Kaler

    2014-12-01

    Full Text Available Droplet microfluidics (DMF is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can generate external stimuli, to either actively or passively control the shape and positioning of fluidic droplets over patterned substrates. In this review article, we focus on the operation and utility of electro-actuation-based DMF devices, which utilize one or more micro-/nano-patterned substrates to facilitate electric field-based handling of chemical and/or biological samples. The underlying theory of DMF actuations, device fabrication methods and integration of optical and opto-electronic detectors is discussed in this review. Example applications of such electro-actuation-based DMF devices have also been included, illustrating the various actuation methods and their utility in conducting chip-based laboratory and clinical diagnostic assays.

  14. Dounreay Shuffler diagnostic software operations manual

    Energy Technology Data Exchange (ETDEWEB)

    Eccleston, G.W.; Stuewe, B.; Klosterbuer, S.; Van Lyssel, T.

    1985-07-01

    This operations manual describes the test software for the Dounreay Shuffler. The Shuffler is an assay system, controlled by a Commodore PET computer, that measures the plutonium content in leached hulls at the fuel reprocessing plant in Dounreay, Scotland. The Shuffler contains a /sup 252/Cf neutron source that is moved between storage and irradiation locations to obtain measurement data. A stepping motor control (SMC) module operates the Shuffler and accepts commands from the PET to move the source. This manual briefly describes the Shuffler and provides details on running and using the diagnostic software program. The communications protocol for message transmittal between the PET and SMC is defined and a detailed example of message sending is presented in an appendix.

  15. In Situ Laser Diagnostics for Arc-Jet Facilities Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR Phase I effort, Los Gatos Research (LGR) proposes to develop novel instrumentation based on laser absorption spectroscopy techniques for ultrasensitive...

  16. Dynamic Visualization of SNS Diagnostics Summary Report and System Status

    CERN Document Server

    Blokland, Willem; Long, Cary D; Murphy, Darryl J; Purcell, John D; Sundaram, Madhan

    2005-01-01

    The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based running Embedded Windows XP and LabVIEW. The diagnostics instruments communicate with the control system using the Channel Access (CA) protocol of the Experimental Physics and Industrial Control System (EPICS). This paper describes the Diagnostics Group's approach to collecting data from the instruments, processing it, and presenting live in a summarized way over the web. Effectively, adding a supervisory level to the diagnostics instruments. One application of this data mining is the "Diagnostics Status Page" that summarizes the insert-able devices, transport efficiencies, and the mode of the accelerator in a compact webpage. The displays on the webpage change automatically to show the latest and/o...

  17. Instrumentation for a multichord motional Stark effect diagnostic in KSTAR

    Science.gov (United States)

    Chung, J.; Ko, J.; De Bock, M. F. M.; Jaspers, R. J. E.

    2014-11-01

    The motional Stark effect (MSE) diagnostic is used to measure the radial magnetic pitch angle profile in neutral beam heated plasmas. This information is used to calculate the safety factor, q, with magnetic equilibrium reconstruction codes such as EFIT. The MSE diagnostic is important during active shaping of the q profile to optimize confinement and stability, and it has become a key diagnostic in high performance tokamaks. A multichord photo-elastic modulator (PEM) based MSE system is being developed for a real-time plasma current profile control in Korea Superconducting Tokamak Advanced Research (KSTAR). The PEM-based approach is a standard method that measures the polarization direction of a single Stark line with narrow tunable bandpass filters. A tangential view of the heating beam provides good spatial resolution of 1-3 cm, which provides an opportunity to install 25 spatial channels spanning the major radius from 1.74 m to 2.84 m. Application of real-time control is a long-term technical goal after commissioning the diagnostic in KSTAR, which is expected in 2015. In this paper, we describe the design of this newly-constructed multichord MSE diagnostic in KSTAR.

  18. Instrumentation for a multichord motional Stark effect diagnostic in KSTAR

    Energy Technology Data Exchange (ETDEWEB)

    Chung, J., E-mail: jinil@nfri.re.kr; Ko, J. [National Fusion Research Institute, Yuseong, Daejeon 305-333 (Korea, Republic of); De Bock, M. F. M.; Jaspers, R. J. E. [Eindhoven University of Technology, 5612 AZ, Eindhoven (Netherlands)

    2014-11-15

    The motional Stark effect (MSE) diagnostic is used to measure the radial magnetic pitch angle profile in neutral beam heated plasmas. This information is used to calculate the safety factor, q, with magnetic equilibrium reconstruction codes such as EFIT. The MSE diagnostic is important during active shaping of the q profile to optimize confinement and stability, and it has become a key diagnostic in high performance tokamaks. A multichord photo-elastic modulator (PEM) based MSE system is being developed for a real-time plasma current profile control in Korea Superconducting Tokamak Advanced Research (KSTAR). The PEM-based approach is a standard method that measures the polarization direction of a single Stark line with narrow tunable bandpass filters. A tangential view of the heating beam provides good spatial resolution of 1–3 cm, which provides an opportunity to install 25 spatial channels spanning the major radius from 1.74 m to 2.84 m. Application of real-time control is a long-term technical goal after commissioning the diagnostic in KSTAR, which is expected in 2015. In this paper, we describe the design of this newly-constructed multichord MSE diagnostic in KSTAR.

  19. Design of Three-dimensional Space Electromagnetic Interference Instrument Based on SCM%一种基于单片机的空间立体电磁干扰仪

    Institute of Scientific and Technical Information of China (English)

    马虹

    2011-01-01

    为测试电子产品电磁兼容性,基于MSP430单片机设计一种空间立体电磁干扰仪,提供多角度、多方位、多波段干扰源.设计中在带宽、频率一致性、信号完整性、制作工艺、调试精度等方面进行了深入研究,电路设计尽量采用功能芯片,提高整机的集成度和性能.%The three-dimensional space electromagnetic interference instrument based on MSP430 SCM is introduced which can provide multi-angle, multi-faceted, multi-band interference source for electromagnetic compatibility testing of electronic products. Several aspects include coherence bandwidth, frequency coherence, signal integrity, production process and testing precision in the design are studied. The circuit design used functional chip to improve performance and integration.

  20. Molecular diagnostics and therapeutics for ectopic pregnancy.

    Science.gov (United States)

    Tong, Stephen; Skubisz, Monika M; Horne, Andrew W

    2015-02-01

    Ectopic pregnancies are a serious gynaecological emergency that can be fatal. As such, prompt diagnosis and safe timely treatment is essential. Here, we review the literature on the development of molecularly targeted diagnostics and therapeutics for ectopic pregnancy. A blood-based biomarker that accurately identifies an ectopic pregnancy could be used to offer early diagnostic certainty in cases where ultrasound cannot determine the location of the embryo ('a pregnancy of unknown location'). Molecules examined so far can be broadly grouped into biological themes of relevance to reproduction: (i) Fallopian tube (dys)function, (ii) embryo/trophoblast growth, (iii) corpus luteum function, (iv) inflammation, (v) uterine function and (vi) angiogenesis. While a sensitive and specific biomarker for ectopic pregnancy has yet to be identified, it is possible that improvements in platform technologies or a multi-modal biomarker approach may yield an accurate diagnostic biomarker test. Furthermore, with the advent of better imaging technology, the need for a blood-based biomarker test may be superseded by improvements in ultrasound or magnetic resonance imaging technology. There have been some recent preclinical studies describing molecularly targeted therapeutic approaches for ectopic pregnancy. Notably, bench-to-bedside studies have examined the use of combination gefitinib (orally available epidermal growth factor receptor inhibitor) and methotrexate. Preclinical studies suggest that combination gefitinib and methotrexate is highly effective in inducing placental cell death, and is significantly more effective than methotrexate alone. In early human trials, encouraging preliminary efficacy data have shown that combination gefitinib and methotrexate can rapidly resolve tubal ectopic pregnancies, and large extra-tubal ectopic pregnancies. If a large clinical randomized controlled trial confirms these findings, combination gefitinib and methotrexate could become a new

  1. Fetal thermal effects of diagnostic ultrasound.

    Science.gov (United States)

    Abramowicz, Jacques S; Barnett, Stanley B; Duck, Francis A; Edmonds, Peter D; Hynynen, Kullervo H; Ziskin, Marvin C

    2008-04-01

    Processes that can produce a biological effect with some degree of heating (ie, about 1 degrees C above the physiologic temperature) act via a thermal mechanism. Investigations with laboratory animals have documented that pulsed ultrasound can produce elevations of temperature and damage in biological tissues in vivo, particularly in the presence of bone (intracranial temperature elevation). Acoustic outputs used to induce these adverse bioeffects are within the diagnostic range, although exposure times are usually considerably longer than in clinical practice. Conditions present in early pregnancy, such as lack of perfusion, may favor bioeffects. Thermally induced teratogenesis has been shown in many animal studies, as well as several controlled human studies; however, human studies have not shown a causal relationship between diagnostic ultrasound exposure during pregnancy and adverse biological effects to the fetus. All human epidemiologic studies, however, were conducted with commercially available devices predating 1992, that is, with acoustic outputs not exceeding a spatial-peak temporal-average intensity of 94 mW/cm2. Current limits in the United States allow a spatial-peak temporal-average intensity of 720 mW/cm2 for fetal applications. The synergistic effect of a raised body temperature (febrile status) and ultrasound insonation has not been examined in depth. Available evidence, experimental or epidemiologic, is insufficient to conclude that there is a causal relationship between obstetric diagnostic ultrasound exposure and obvious adverse thermal effects to the fetus. However, very subtle effects cannot be ruled out and indicate a need for further research, although research in humans may be extremely difficult to realize.

  2. The Motional Stark Effect diagnostic at TEXTOR-94

    NARCIS (Netherlands)

    Elzendoorn, B. S. Q.; R. Jaspers,

    2001-01-01

    Knowledge of the current distribution in a tokamak is indispensable for an understanding of the energy transport in the plasma and controlling instabilities. A diagnostic exploiting the Motional Stark Effect (MSE) has the potential to obtain this quantity. This is based on a measurement of the polar

  3. Assessment of classical swine fever diagnostics and vaccine performance

    NARCIS (Netherlands)

    Loeffen, W.L.A.

    2006-01-01

    Rapid and accurate diagnosis is of the utmost importance in the control of epizootic diseases such as classical swine fever (CSF), and efficacious vaccination can be used as a supporting tool. While most of the recently developed CSF vaccines and diagnostic kits are mostly validated according to

  4. 78 FR 39327 - Bio Diagnostic International; Denial of Application

    Science.gov (United States)

    2013-07-01

    ... Doc No: 2013-15704] DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 11-63] Bio... of Diversion Control, Drug Enforcement Administration, issued an Order to Show Cause to Bio... application of Bio Diagnostic International, Inc., for a DEA Certificate of Registration as a distributor...

  5. Assessment of classical swine fever diagnostics and vaccine performance

    NARCIS (Netherlands)

    Loeffen, W.L.A.

    2006-01-01

    Rapid and accurate diagnosis is of the utmost importance in the control of epizootic diseases such as classical swine fever (CSF), and efficacious vaccination can be used as a supporting tool. While most of the recently developed CSF vaccines and diagnostic kits are mostly validated according to Wor

  6. Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group

    Science.gov (United States)

    Braulke, Friederike; Platzbecker, Uwe; Müller-Thomas, Catharina; Götze, Katharina; Germing, Ulrich; Brümmendorf, Tim H.; Nolte, Florian; Hofmann, Wolf-Karsten; Giagounidis, Aristoteles A. N.; Lübbert, Michael; Greenberg, Peter L.; Bennett, John M.; Solé, Francesc; Mallo, Mar; Slovak, Marilyn L.; Ohyashiki, Kazuma; Le Beau, Michelle M.; Tüchler, Heinz; Pfeilstöcker, Michael; Nösslinger, Thomas; Hildebrandt, Barbara; Shirneshan, Katayoon; Aul, Carlo; Stauder, Reinhard; Sperr, Wolfgang R.; Valent, Peter; Fonatsch, Christa; Trümper, Lorenz; Haase, Detlef; Schanz, Julie

    2015-01-01

    International Prognostic Scoring Systems are used to determine the individual risk profile of myelodysplastic syndrome patients. For the assessment of International Prognostic Scoring Systems, an adequate chromosome banding analysis of the bone marrow is essential. Cytogenetic information is not available for a substantial number of patients (5%–20%) with dry marrow or an insufficient number of metaphase cells. For these patients, a valid risk classification is impossible. In the study presented here, the International Prognostic Scoring Systems were validated based on fluorescence in situ hybridization analyses using extended probe panels applied to cluster of differentiation 34 positive (CD34+) peripheral blood cells of 328 MDS patients of our prospective multicenter German diagnostic study and compared to chromosome banding results of 2902 previously published patients with myelodysplastic syndromes. For cytogenetic risk classification by fluorescence in situ hybridization analyses of CD34+ peripheral blood cells, the groups differed significantly for overall and leukemia-free survival by uni- and multivariate analyses without discrepancies between treated and untreated patients. Including cytogenetic data of fluorescence in situ hybridization analyses of peripheral CD34+ blood cells (instead of bone marrow banding analysis) into the complete International Prognostic Scoring System assessment, the prognostic risk groups separated significantly for overall and leukemia-free survival. Our data show that a reliable stratification to the risk groups of the International Prognostic Scoring Systems is possible from peripheral blood in patients with missing chromosome banding analysis by using a comprehensive probe panel (clinicaltrials.gov identifier:01355913). PMID:25344522

  7. Diagnostics

    DEFF Research Database (Denmark)

    Donné, A.J.H.; Costley, A.E.; Barnsley, R.

    2007-01-01

    In order to support the operation of ITER and the planned experimental programme an extensive set of plasma and first wall measurements will be required. The number and type of required measurements will be similar to those made on the present-day large tokamaks while the specification of the mea...

  8. Advances in medical diagnostic technology

    CERN Document Server

    Lai, Khin Wee; Mohamad Salim, Maheza Irna; Ong, Sang-Bing; Utama, Nugraha Priya; Myint, Yin Mon; Mohd Noor, Norliza; Supriyanto, Eko

    2014-01-01

    This book provides the most recent findings and knowledge in advanced diagnostics technology, covering a wide spectrum including brain activity analysis, breast and lung cancer detection, echocardiography, computer aided skeletal assessment to mitochondrial biology imaging at the cellular level. The authors explored magneto acoustic approaches and tissue elasticity imaging for the purpose of breast cancer detection. Perspectives in fetal echocardiography from an image processing angle are included. Diagnostic imaging in the field of mitochondrial diseases as well as the use of Computer-Aided System (CAD) are also discussed in the book. This book will be useful for students, lecturers or professional researchers in the field of biomedical sciences and image processing.

  9. Huntington Disease: Molecular Diagnostics Approach.

    Science.gov (United States)

    Bastepe, Murat; Xin, Winnie

    2015-10-06

    Huntington disease (HD) is caused by expansion of a CAG trinucleotide repeat in the first exon of the Huntingtin (HTT) gene. Molecular testing of Huntington disease for diagnostic confirmation and disease prediction requires detection of the CAG repeat expansion. There are three main types of HD genetic testing: (1) diagnostic testing to confirm or rule out disease, (2) presymptomatic testing to determine whether an at-risk individual inherited the expanded allele, and (3) prenatal testing to determine whether the fetus has inherited the expanded allele. This unit includes protocols that describe the complementary use of polymerase chain reactions (PCR) and Southern blot hybridization to accurately measure the CAG trinucleotide repeat size and interpret the test results. In addition, an indirect linkage analysis that does not reveal the unwanted parental HD status in a prenatal testing will also be discussed.

  10. SALIVA AS A DIAGNOSTIC FLUID

    Directory of Open Access Journals (Sweden)

    Pezelj-Ribarić Sonja

    2015-12-01

    Full Text Available Saliva is a readily available oral fluid with many functions, from digestion, maintenance of oral tissues' integrity, to caries prevention. Changes regarding its secretion may be divided into qualitative and quantitative: both of them are a consequence of certain conditions/diseases (e.g. internal factors or nutrients/drugs ingested (e.g. external factors. During the last 15 years, technological advances gave a significant momentum to utilization of saliva as a diagnostic tool. Analysis of saliva, just like the blood analysis, has two main objectives: to identify the subjects suffering from a certain disorder, and to follow the development and progress of therapy. This paper provides an overview of possibilities for the use of saliva for diagnostic purposes and gives specific examples of some clinical investigations, with the final aim to stimulate the use of this noninvasive means for the health care promotion.

  11. [Diagnostic workup of fragrance allergy].

    Science.gov (United States)

    Geier, J; Uter, W

    2015-09-01

    The diagnostic workup of contact allergy to fragrances must not be limited to patch testing with the two well-established fragrance mixes. False-positive reactions to these mixes occur in up to 50 % of the patch tested patients. For the diagnostic work-up of positive reactions, and in cases of suspected fragrance allergy, patch testing with the single mix components and additional fragrances is mandatory. Frequently sensitizing fragrance materials are the 14 components of the two fragrance mixes and tree moss (Evernia furfuracea), ylang ylang oil (I + II; Cananga odorata), lemongrass oil (Cymbopogon schoenanthus), sandalwood oil (Santalum album), jasmine absolute (Jasminum spp.), and, less frequently, clove oil (Eugenia caryophyllus), cedarwood oil (Cedrus atlantica/deodara, Juniperus virginiana), Neroli oil (Citrus aurantium amara flower oil), salicylaldehyde, narcissus absolute (Narcissus spp.), and patchouli oil (Pogostemon cablin).

  12. Novette diagnostic support. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cirigliano, R.; Franco, E.; Koppel, L.; Rodrigues, B.; Smith, J.

    1985-02-01

    The primary research areas were the following: (1) contribute x-ray diagnostic, experimental, and data reduction and analysis support for the Novette DANTE x-ray spectrometer experiments. This effort was expanded to improve the overall quality of the Novette database; (2) experimental and calculational characterization of the x-ray imaging properties of an ellipsoidal x-ray collection optic serving as a sensitivity enhancing component of the Transmission Grating Streak Spectrometer; (3) performance simulation of the x-ray dispersion properties of candidate x-ray laser cavity, normal incidence end-mirror optics; (4) contribute x-ray diagnostic, experimental, and data reduction and analysis support for the Novette Henway crystal spectrometer and the MCPIGS microchannel plate intensified grazing incident spectrometer experiments; and (5) perform a technical performance vs cost evaluation of commercially available hardware required to perform the NOVA neutron time-of-flight experiments.

  13. Hebephilia: quintessence of diagnostic pretextuality.

    Science.gov (United States)

    Franklin, Karen

    2010-01-01

    Hebephilia is an archaic term used to describe adult sexual attraction to adolescents. Prior to the advent of contemporary sexually violent predator laws, the term was not found in any dictionary or formal diagnostic system. Overnight, it is on the fast track toward recognition as a psychiatric condition meriting inclusion in the upcoming fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. This article traces the sudden emergence and popularity of hebephilia to pressure from the legal arena and, specifically, to the legal mandate of a serious mental abnormality for civil commitment of sex offenders. Hebephilia is proposed as a quintessential example of pretextuality, in which special interests promote a pseudoscientific construct that furthers an implicit, instrumental goal. Inherent problems with the construct's reliability and validity are discussed. A warning is issued about unintended consequences if hebephilia or its relative, pedohebephilia, make their way into the DSM-5, due out in 2013. Copyright © 2010 John Wiley & Sons, Ltd.

  14. Saliva as a diagnostic fluid.

    Science.gov (United States)

    Samaranayake, Lakshman

    2007-10-01

    The use of saliva as a diagnostic fluid for various human ailments is gaining popularity as it offers distinct advantages over serum. These include the non-invasive nature of saliva collection compared with phlebotomy, simplicity of collection even for individuals with a modest training and the cost-effective applicability for screening large populations. Whole saliva is most frequently used for diagnosis of systemic diseases since it is readily collected and contains serum constituents while gland-specific saliva is useful for investigating pathology of major salivary glands. Broadly, saliva analysis is currently used for the diagnosis of infectious and malignant diseases, hereditary disorders, autoimmune diseases, and endocrine disorders, as well as for the assessment of therapeutic drug levels, particularly in monitoring drug abuse. This review addresses the current status of salivary diagnostics and their future potential.

  15. Diagnostics Beamline for the SRF Gun Project

    CERN Document Server

    Kamps, T; Goldammer, K; Krämer, Dietrich; Kuske, P; Kuszynski, J; Lipka, D; Marhauser, F; Quast, T; Richter, R

    2005-01-01

    A superconducting rf photo electron injector (SRF gun) is currently under construction by a collaboration between BESSY, DESY, FZR and MBI. The project aims at the design and setup of an CW SRF gun including a diagnostics beamline for the ELBE FEL and to address R&D issues on low emittance injectors for future light sources such as the BESSY FEL. Of critical importance for the injector performance is the control of the electron beam parameters. For this reason a compact diagnostics beamline is under development serving a multitude of operation settings ranging from low-charge (77pC), low-emittance (1 pi mm mrad) mode to high-charge (2.5nC) operation of the gun. For these operation modes beam dynamics simulations are resulting in boundary conditions for the beam instrumentation. Proven and mature technology is projected wherever possible, for example for current and beam position monitoring. The layout of the beam profile and emittance measurement systems is described. For the bunch length, which varies be...

  16. Newer diagnostic approaches to intestinal protozoa.

    Science.gov (United States)

    van Lieshout, Lisette; Verweij, Jaco J

    2010-10-01

    To update the reader on the latest developments in the laboratory diagnosis of intestinal protozoa. Correct identification of a diarrhoea causing pathogens is essential for the choice of treatment in an individual patient as well as to map the aetiology of diarrhoea in a variety of patient populations. Classical diagnosis of diarrhoea causing protozoa by microscopic examination of a stool sample lacks both sensitivity and specificity. Alternative diagnostic platforms are discussed. Recent literature on the diagnosis of intestinal protozoa has focused mainly on nucleic acid-based assays, in particular the specific detection of parasite DNA in stool samples using real-time PCR. In addition, the trend has been moving from single pathogen detection to a multiplex approach, allowing simultaneous identification of multiple parasites. Different combinations of targets can be used within a routine diagnostic setting, depending on the patient population, such as children, immunocompromised individuals and those who have been travelling to tropical regions. Large-scale monitoring and evaluation of control strategies become feasible due to automation and high-throughput facilities. Improved technology also has become available for differentiating protozoa subspecies, which facilitates outbreak investigations and extensive research in molecular epidemiology.

  17. Diagnostic radiology dosimetry: status and trends

    Energy Technology Data Exchange (ETDEWEB)

    Rivera M, T., E-mail: trivera@ipn.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria 694, 11500 Mexico D. F. (Mexico)

    2015-10-15

    Full text: Medical radiation is by far the largest man-made source of public exposure to ionizing radiation. Since 1970 the expression of protection standards shifted from a dose- to a risk-based approach, with dose limits established to yield risks to radiation workers comparable with those for workers in other safe industries. Another hand, worldwide interest in patient dose measurement was stimulated by the publication of Patient Dose Reduction in Diagnostic Radiology by the UK National Radiological Protection Board (NRPB). In response to heightened awareness of the importance of patient dose contributed by radiology procedures, there has been a general trend to effect control of patient doses by applying the principles of optimization coupled with an increase in regulatory enforcement. In this sense, thermoluminescent dosimetry (TLD) has been actively proposed in the last 3 decades thanks to their successful applications in diagnostic radiology. At the same time, it is emerged as the best radiation dosimetry method. The present work presents advantages of thermoluminescent dosimetry for X-ray beams measurements and its optimization. (Author)

  18. The appropriateness of XML for diagnostic description

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)], E-mail: andre.neto@cfn.ist.utl.pt; Lister, J.B. [CRPP-EPFL, Association EURATOM-Confederation Suisse, 1015 Lausanne (Switzerland); Fernandes, H. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Yonekawa, I. [JAEA, Japan Atomic Energy Agency Naka (Japan); Varandas, C.A.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)

    2007-10-15

    A standard for the self-description of fusion plasma diagnostics will be required in the near future. The motivation is to maintain and organize the information on all the components of a laboratory experiment, from the hardware to the access security, to save time and money. Since there is no existing standard to organize this kind of information, every EU Association stores and organizes each experiment in different ways. This can lead to severe problems when the particular organization schema is poorly documented. Standardization is the key to solve these problems. From the commercial information on the diagnostic (component supplier; component price) to the hardware description (component specifications; drawings) to the operation of the equipment (finite state machines) through change control (who changed what and when) and internationalization (information at least in English and a local language). This problem will be met on the ITER project, for which a solution is essential. A strong candidate solution is the Extensible Markup Language (XML). In this paper, a review of the current status of XML related technologies will be presented.

  19. Aquagenic urticaria: diagnostic and management challenges

    Directory of Open Access Journals (Sweden)

    Rothbaum R

    2016-11-01

    Full Text Available Robert Rothbaum, Jean S McGee Department of Dermatology, Boston University School of Medicine, Boston, MA, USA Abstract: Aquagenic urticaria (AU is a rare inducible form of physical urticaria, which occurs in response to cutaneous exposure to water, including sweat and tears. Patients present with characteristic 1–3 mm folliculocentric wheals with surrounding 1–3 cm erythematous flares within 20–30 minutes following skin contact with water. In rare cases, there are concomitant systemic symptoms, such as wheezing or shortness of breath. The pathogenesis of AU is poorly understood at this time, and it appears to be mediated in both a histamine-dependent and independent manner. Diagnosis is based on eliciting a thorough clinical history combined with a water challenge test. Some patients may need to undergo further testing to exclude other physical urticarias. Rarely, multiple physical urticarias can be present in one patient, which can complicate diagnosis and treatment. Currently, the first-line therapy for AU is an oral administration of nonsedating, second-generation H1 antihistamines, but many patients may require further interventions to have adequate symptomatic control. In this review, we discuss the diagnostic and management challenges of AU. We review the key diagnostic features that differentiate AU from other physical urticarias. We additionally describe a therapeutic ladder for the treatment of AU and the rationale supporting these treatments. Keywords: aquagenic urticaria, physical urticaria, inducible urticaria, diagnosis, management

  20. Aquagenic urticaria: diagnostic and management challenges

    Science.gov (United States)

    Rothbaum, Robert; McGee, Jean S

    2016-01-01

    Aquagenic urticaria (AU) is a rare inducible form of physical urticaria, which occurs in response to cutaneous exposure to water, including sweat and tears. Patients present with characteristic 1–3 mm folliculocentric wheals with surrounding 1–3 cm erythematous flares within 20–30 minutes following skin contact with water. In rare cases, there are concomitant systemic symptoms, such as wheezing or shortness of breath. The pathogenesis of AU is poorly understood at this time, and it appears to be mediated in both a histamine-dependent and independent manner. Diagnosis is based on eliciting a thorough clinical history combined with a water challenge test. Some patients may need to undergo further testing to exclude other physical urticarias. Rarely, multiple physical urticarias can be present in one patient, which can complicate diagnosis and treatment. Currently, the first-line therapy for AU is an oral administration of nonsedating, second-generation H1 antihistamines, but many patients may require further interventions to have adequate symptomatic control. In this review, we discuss the diagnostic and management challenges of AU. We review the key diagnostic features that differentiate AU from other physical urticarias. We additionally describe a therapeutic ladder for the treatment of AU and the rationale supporting these treatments. PMID:27942227

  1. [Eosinophilia - inflammation, proliferation, reaction. Part 1: diagnostics].

    Science.gov (United States)

    Balke, L; Günther, A; Zeuner, R; Bewig, B

    2014-05-01

    Eosinophilia presents a challenge to differential diagnostics due to the multitude of possible causes. An initial difficulty is often to distinguish between threatening disease symptoms and relatively harmless secondary reactions. A highly dynamic clinical progression with severe impairment of the vital functions, like breathing, for example, can make swift action necessary. An example of this is known as acute eosinophile pneumonia, which can often only be controlled with the rapid use of high steroid doses. However, a peripheral blood eosinophilia must not lead to an automatic use of steroids before the most important core tests, as this can compromise further diagnostic measures. Furthermore, less dramatic courses require careful handling of an eosinophilia. Various pneumological, infectological, rheumatological or haematological / oncological disease patterns with a prolonged course can develop seriously if they are not recognised in time and treated in a targeted manner. There is no guideline for eosinophile clinical pictures in general. Already the recommendations for a structured diagnosis are scarce and are often concentrated on internist emphases. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Diagnostics Beamline for the SRF Gun Project

    Energy Technology Data Exchange (ETDEWEB)

    T. Kamps; V. Durr; K. Goldammer; D. Kramer; P. Kuske; J. Kuszynski; D. Lipka; F. Marhauser; T. Quast; D. Richter; U. Lehnert; P. Michel; J. Teichert; P. Evtushenko; I. Will

    2005-08-22

    A superconducting radio-frequency photo electron injector (SRF gun) is currently under construction by a collaboration of BESSY, DESY, FZR and MBI. The project aims at the design and setup of a CW SRF gun including a diagnostics beamline for the ELBE FEL and to address R&D issues on low emittance injectors for future light sources such as the BESSY FEL. Of critical importance for the injector performance is the control of the electron beam parameters. For this reason a compact diagnostics beamline is under development serving a multitude of operation settings ranging from low-charge (77pC), low-emittance (1 mm mrad) mode to high-charge (2.5nC) operation of the gun. For these operation modes beam dynamics simulations are resulting in boundary conditions for the beam instrumentation. Proven and mature technology is projected wherever possible, for example for current and beam position monitoring. The layout of the beam profile and emittance measurement systems is described. For the bunch length, which varies between 5 ps and 50 ps, two schemes using electro-optical sampling and Cherenkov radiation are detailed. The beam energy and energy spread is measured with a 180-degree spectrometer.

  3. Diagnostic Methods for Feline Coronavirus: A Review

    Directory of Open Access Journals (Sweden)

    Saeed Sharif

    2010-01-01

    Full Text Available Feline coronaviruses (FCoVs are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP. FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV. Reverse transcriptase polymerase chain reaction (RT-PCR has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis.

  4. Molecular diagnostics and parasitic disease.

    Science.gov (United States)

    Vasoo, Shawn; Pritt, Bobbi S

    2013-09-01

    Molecular parasitology represents an emerging field in microbiology diagnostics. Although most assays use nonstandardized, laboratory-developed methods, a few commercial systems have recently become available and are slowly being introduced into larger laboratories. In addition, a few methodologies show promise for use in field settings in which parasitic infections are endemic. This article reviews the available techniques and their applications to major parasitic diseases such as malaria, leishmaniasis, and trichomoniasis.

  5. [Diagnostic approach to infectious endocarditis].

    Science.gov (United States)

    Parize, Perrine; Mainardi, Jean-Luc

    2012-04-01

    Major advances in imaging and microbiological procedures have changed the diagnostic approach of infective endocarditis. New imaging tools have improved the search of local complications, systemic embolism and diagnosis of infection of cardiac devices. Moreover, microbiological diagnosis has been transformed by molecular techniques as long as these procedures have highlighted microorganisms thus far neglected by classical techniques. Despite these advances, endocarditis remained a clinical diagnosis which still depends on a high index of clinical suspicion.

  6. Laser Diagnostics for Spacecraft Propulsion

    Science.gov (United States)

    2015-10-13

    AFTC/PA Clearance No. XXXX 8 Ion Engines & Hall Thrusters Operation Ion engines and Hall thrusters are electrostatic propulsion devices • Ion Engines... Hall thrusters are gridless electrostatic thrusters – Propellant ionized by electrons trapped in magnetic field – Ions accelerated by an electric field...Briefing Charts 3. DATES COVERED (From - To) 21 September 2015 – 13 October 2015 4. TITLE AND SUBTITLE Laser Diagnostics for Spacecraft Propulsion 5a

  7. Gear Fatigue Diagnostics and Prognostics

    Science.gov (United States)

    2013-01-01

    The first objective was to collect meaningful gear fault progression data starting from healthy NASA-designed spur test gears and ending with failed...and D. P. Townsend, "Analysis of the effects of surface pitting and wear on the vibration of a gear transmission system," Tribology International...Reporting Period: April 15, 2012 to September 27, 2012 Attached is the Gear Fatigue Diagnostics and Prognostics project progress report for the

  8. Biomedical photonics handbook biomedical diagnostics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, studen

  9. Drugs and diagnostic innovations to improve global health.

    Science.gov (United States)

    Peeling, Rosanna W; Nwaka, Solomon

    2011-09-01

    Infectious diseases remain the major cause of morbidity and mortality in the developing world. Affordable effective drugs and diagnostics are critical for patient management and disease control but the development of new drugs and diagnostics is too slow to keep up with the emergence and spread of infectious diseases around the world. Innovative collaborative research and development involving disease endemic countries and developed countries are urgently needed to accelerate progress along the path from discovery to product adoption. These emerging approaches and the need for increased investment in human and financial resources to support them are discussed.

  10. [Oral fluid bacteriocidal activity in complex diagnostics of oral disbiosis].

    Science.gov (United States)

    Rabinovich, O F; Abramova, E S

    2012-01-01

    The possibility of examination of oral fluid bacteriocidal activity in complex diagnostics of oral mucosa disbiosis was evaluated. Thirty-seven patients were included in complex clinical and laboratory studies. The patients were divided in two groups: main group (30 patients exhibiting various grades of oral mucosa disbiosis) and control group (7 patients with no signs of oral disbiosis). The oral fluid bacteriocidal activity was examined by means of laser flow cytometry. Study results proved oral fluid bacteriocidal activity increase to correlate with the grade of oral mucosa disbiosis thus confirming the usefulness of the method in complex diagnostics of oral disbiosis.

  11. First rank symptoms: concepts and diagnostic utility

    African Journals Online (AJOL)

    diagnostic criteria for schizophrenia, having initially been proposed by Schneider ... frequency in a given disorder to be diagnostically useful.2. This review, whilst ... and delusional perception appearing in criterion B. In DSM. III11 and DSM IV ...

  12. A diagnostic approach to test priorization

    NARCIS (Netherlands)

    Gonzalez-Sanchez, A.; Abreu, R.; Gross, H.; Van Gemund, A.

    2010-01-01

    In development processes with high code production rates testing typically triggers fault diagnosis to localize the detected failures. However, current test prioritization algorithms are tuned for failure detection rate rather than diagnostic information. Consequently, unnecessary diagnostic effort

  13. Diagnostic performance of screening methods for urinary ...

    African Journals Online (AJOL)

    conducted using various indirect diagnostic tests such as interview ... haematuria and dysuria, visual examination of urine specimen ... Abstract. Background: Indirect diagnostic methods in urinary schistosomiasis are widely used for screening.

  14. Diagnostic guidlines for occupational epicondylitis

    Directory of Open Access Journals (Sweden)

    Patrycja Krawczyk-Szulc

    2015-07-01

    Full Text Available Making final decisions on the occupational etiology of musculoskeletal diseases is often difficult and problematic at every stage of the diagnostic procedure. Taking into account the need to facilitate decision-making about the causal relationship between the diagnosed disease entity and the working conditions guidelines for the recognition of work-related musculoskeletal diseases have been developed. This paper presents the guidelines for the diagnosis of occupational etiology of humeral epicondylitis, one of the most common occupational disease of the musculoskeletal system in Poland. The developed guidelines have been based on the literature data concerning occupational risk factors of humeral epicondylitis, workload classification, including repetitive movements, awkward postures, and force. Some criteria applied in ergonomic evaluation methods were also included. The presented diagnostic guidelines define approximate benchmarks for stating (after excluding non-occupational etiology that the identified humeral epicondylitis, is related to the way of working. Crucial work factors that should be analyzed include an operating time of movements overloading tendons connecting to the epicondyle, repetition and force used to perform occupational activities. The developed guidelines are aimed to facilitate occupational physicians diagnostic and certification procedures in case of humeral epicondylitis and determination whether there is a likelihood of its occupational etiology. Med Pr 2015;66(3:443–450

  15. [Diagnostic guidlines for occupational epicondylitis].

    Science.gov (United States)

    Krawczyk-Szulc, Patrycja; Wągrowska-Koski, Ewa; Puzder, Anna; Markowski, Przemysław; Walusiak-Skorupa, Jolanta

    2015-01-01

    Making final decisions on the occupational etiology of musculoskeletal diseases is often difficult and problematic at every stage of the diagnostic procedure. Taking into account the need to facilitate decision-making about the causal relationship between the diagnosed disease entity and the working conditions guidelines for the recognition of work-related musculoskeletal diseases have been developed. This paper presents the guidelines for the diagnosis of occupational etiology of humeral epicondylitis, one of the most common occupational disease of the musculoskeletal system in Poland. The developed guidelines have been based on the literature data concerning occupational risk factors of humeral epicondylitis, workload classification, including repetitive movements, awkward postures, and force. Some criteria applied in ergonomic evaluation methods were also included. The presented diagnostic guidelines define approximate benchmarks for stating (after excluding non-occupational etiology) that the identified humeral epicondylitis, is related to the way of working. Crucial work factors that should be analyzed include an operating time of movements overloading tendons connecting to the epicondyle, repetition and force used to perform occupational activities. The developed guidelines are aimed to facilitate occupational physicians diagnostic and certification procedures in case of humeral epicondylitis and determination whether there is a likelihood of its occupational etiology.

  16. Sequencing Needs for Viral Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, S N; Lam, M; Mulakken, N J; Torres, C L; Smith, J R; Slezak, T

    2004-01-26

    We built a system to guide decisions regarding the amount of genomic sequencing required to develop diagnostic DNA signatures, which are short sequences that are sufficient to uniquely identify a viral species. We used our existing DNA diagnostic signature prediction pipeline, which selects regions of a target species genome that are conserved among strains of the target (for reliability, to prevent false negatives) and unique relative to other species (for specificity, to avoid false positives). We performed simulations, based on existing sequence data, to assess the number of genome sequences of a target species and of close phylogenetic relatives (''near neighbors'') that are required to predict diagnostic signature regions that are conserved among strains of the target species and unique relative to other bacterial and viral species. For DNA viruses such as variola (smallpox), three target genomes provide sufficient guidance for selecting species-wide signatures. Three near neighbor genomes are critical for species specificity. In contrast, most RNA viruses require four target genomes and no near neighbor genomes, since lack of conservation among strains is more limiting than uniqueness. SARS and Ebola Zaire are exceptional, as additional target genomes currently do not improve predictions, but near neighbor sequences are urgently needed. Our results also indicate that double stranded DNA viruses are more conserved among strains than are RNA viruses, since in most cases there was at least one conserved signature candidate for the DNA viruses and zero conserved signature candidates for the RNA viruses.

  17. Temporomandibular joint diagnostics using CBCT

    Science.gov (United States)

    Abrahamsson, A-K; Kristensen, M; Arvidsson, L Z

    2015-01-01

    The present review will give an update on temporomandibular joint (TMJ) imaging using CBCT. It will focus on diagnostic accuracy and the value of CBCT compared with other imaging modalities for the evaluation of TMJs in different categories of patients; osteoarthritis (OA), juvenile OA, rheumatoid arthritis and related joint diseases, juvenile idiopathic arthritis and other intra-articular conditions. Finally, sections on other aspects of CBCT research related to the TMJ, clinical decision-making and concluding remarks are added. CBCT has emerged as a cost- and dose-effective imaging modality for the diagnostic assessment of a variety of TMJ conditions. The imaging modality has been found to be superior to conventional radiographical examinations as well as MRI in assessment of the TMJ. However, it should be emphasized that the diagnostic information obtained is limited to the morphology of the osseous joint components, cortical bone integrity and subcortical bone destruction/production. For evaluation of soft-tissue abnormalities, MRI is mandatory. There is an obvious need for research on the impact of CBCT examinations on patient outcome. PMID:25369205

  18. Diagnostic interventions in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Thrall, J.H.; Swanson, D.P.

    1989-01-01

    Diagnostic interventions in nuclear medicine may be defined as the coadministration of a nonradioactive drug or application of a physical stimulus or physiologic maneuver to enhance the diagnostic utility of a nuclear medicine test. The rationale for each interventional maneuver follows from the physiology or metabolism of the particular organ or organ system under evaluation. Diagnostic inference is drawn from the pattern of change in the biodistribution of the tracer in response to the intervention-induced change in metabolism or function. In current practice, the most commonly performed interventional maneuvers are aimed at studies of the heart, genitourinary system, hepatobiliary system, and gastrointestinal tract. The single most commonly performed interventional study in the United States is the stress Thallium-201 myocardial perfusion scan aimed at the diagnosis of coronary artery disease. The stress portion of the study is accomplished with dynamic leg exercise on a treadmill and is aimed at increasing myocardial oxygen demands. Areas of myocardium distal to hemodynamically significant lesions in the coronary arteries become ischemic at peak stress due to the inability of the stenotic vessel to respond to the oxygen demand/blood flow needs of the myocardium. Ischemic areas are readily recognized as photopenic defects on scans obtained immediately after exercise, with normalization upon delayed imaging. Diuresis renography is aimed at the differential diagnosis of hydroureteronephrosis. By challenging the urinary tract collecting structures with an augmented urine flow, dilated, unobstructed systems can be differentiated from systems with significant mechanical obstruction. 137 references.

  19. Diagnostic and therapeutic peroral cholangioscopy

    Directory of Open Access Journals (Sweden)

    Jong Ho Moon

    2012-01-01

    Full Text Available Peroral cholangioscopy (POC provides direct visualization of the bile duct and facilitates diagnostic or therapeutic intervention. The currently available single-operator POC systems are "Mother-baby" scope system, SpyGlass direct visualization system, and direct POC using a regular ultra-slim upper endoscope. Direct POC using an ultra-slim upper endoscope having a larger 2-mm working channel can provide a valuable and economic solution for evaluating bile-duct lesions. Main diagnostic procedures under direct POC are visual characterization and optically guided target biopsy for the indeterminate bile duct lesion. Image-enhanced endoscopy such as narrow-band imaging has shown promise for more detailed evaluation of mucosal abnormality and can be performed under direct POC. Intracorporeal lithotripsy such as electrohydraulic lithotripsy or laser lithotripsy is a main therapeutic intervention of direct POC for patients with bile duct stones that are resistant to conventional endoscopic stone-removal procedures. Besides, tumor ablation therapy, such as photodynamic therapy and argon plasma coagulation may be also performed using direct POC. Further developments of the endoscope and specialized accessories or devices are expected to facilitate diagnostic and therapeutic role of this cholangioscopic procedure.

  20. Fluorescence diagnostics in oncological gynecology

    Science.gov (United States)

    Belyaeva, Ludmila A.; Adamyan, Leila V.; Kozachenko, Vladimir P.; Stratonnikov, Alexander A.; Stranadko, Eugene F.; Loschenov, Victor B.

    2003-10-01

    The method of fluorescent diagnostics (FD) of tumors is a promising tool that may allow to increase sensitivity of tumor detection especially at initial stages. One of the most promising photosensitizers today is 5-aminolevulinic acid (5-ALA) that, actually, is not photosensitizer itself but precursor of protoporphyrin IX (PpIX). This paper deals with cancer diagnostics in gynecology by means of ALA-induced Pp IX laser-fluorescence spectroscopy. The tissue fluorescence spectra in vivo were studied in patients with various pathologies of ovaries, uterine and vulva after 5-aminolevulinic acid administration. It was shown that different pathologies varies in accumulation of Pp IX. Coefficient of fluorescence kf for normal tissue is not high, but exceptions are endometrium and mucous membrane of uterine tubes. Benign tumors of uterus and ovary have low values of kf, but polyps of endometrium exhibit high kf. Optical express-biopsy is important for diagnosis of ovarian cancer and micrometastatic spread. Coefficients of diagnostic contrast were determined for cancer of endometrium, cervical cancer, vulvar cancer.

  1. DNA Microarray-Based Diagnostics.

    Science.gov (United States)

    Marzancola, Mahsa Gharibi; Sedighi, Abootaleb; Li, Paul C H

    2016-01-01

    The DNA microarray technology is currently a useful biomedical tool which has been developed for a variety of diagnostic applications. However, the development pathway has not been smooth and the technology has faced some challenges. The reliability of the microarray data and also the clinical utility of the results in the early days were criticized. These criticisms added to the severe competition from other techniques, such as next-generation sequencing (NGS), impacting the growth of microarray-based tests in the molecular diagnostic market.Thanks to the advances in the underlying technologies as well as the tremendous effort offered by the research community and commercial vendors, these challenges have mostly been addressed. Nowadays, the microarray platform has achieved sufficient standardization and method validation as well as efficient probe printing, liquid handling and signal visualization. Integration of various steps of the microarray assay into a harmonized and miniaturized handheld lab-on-a-chip (LOC) device has been a goal for the microarray community. In this respect, notable progress has been achieved in coupling the DNA microarray with the liquid manipulation microsystem as well as the supporting subsystem that will generate the stand-alone LOC device.In this chapter, we discuss the major challenges that microarray technology has faced in its almost two decades of development and also describe the solutions to overcome the challenges. In addition, we review the advancements of the technology, especially the progress toward developing the LOC devices for DNA diagnostic applications.

  2. Diagnostics for PLX-alpha

    Science.gov (United States)

    Gilmore, Mark; Hsu, Scott

    2015-11-01

    The goal of the Plasma Liner eXperiment PLX-alpha at Los Alamos National Laboratory is to establish the viability of creating a spherically imploding plasma liner for MIF and HED applications, using a spherical array of supersonic plasma jets launched by innovative contoured-gap coaxial plasma guns. PLX- α experiments will focus in particular on establishing the ram pressure and uniformity scalings of partial and fully spherical plasma liners. In order to characterize these parameters experimentally, a suite of diagnostics is planned, including multi-camera fast imaging, a 16-channel visible interferometer (upgraded from 8 channels) with reconfigurable, fiber-coupled front end, and visible and VUV high-resolution and survey spectroscopy. Tomographic reconstruction and data fusion techniques will be used in conjunction with interferometry, imaging, and synthetic diagnostics from modeling to characterize liner uniformity in 3D. Diagnostic and data analysis design, implementation, and status will be presented. Supported by the Advanced Research Projects Agency - Energy - U.S. Department of Energy.

  3. Diagnostic Measurements for Power Transformers

    Directory of Open Access Journals (Sweden)

    Stefan Tenbohlen

    2016-05-01

    Full Text Available With the increasing age of the primary equipment of the electrical grids there exists also an increasing need to know its internal condition. For this purpose, off- and online diagnostic methods and systems for power transformers have been developed in recent years. Online monitoring is used continuously during operation and offers possibilities to record the relevant stresses which can affect the lifetime. The evaluation of these data offers the possibility of detecting oncoming faults early. In comparison to this, offline methods require disconnecting the transformer from the electrical grid and are used during planned inspections or when the transformer is already failure suspicious. This contribution presents the status and current trends of different diagnostic techniques of power transformers. It provides significant tutorial elements, backed up by case studies, results and some analysis. The broadness and improvements of the presented diagnostic techniques show that the power transformer is not anymore a black box that does not allow a view into its internal condition. Reliable and accurate condition assessment is possible leading to more efficient maintenance strategies.

  4. ITER-like wide-angle infrared thermography and visible observation diagnostic using reflective optics

    NARCIS (Netherlands)

    Gauthier, E.; Roche, H.; Thomas, E.; Droineau, S.; Bertrand, B.; Migozzi, J.B.; Vliegenthart, W.A.; Dague, L.; Andrew, P.; Tiscornia, T.; Sands, D.

    2007-01-01

    Control of the plasma-wall interaction during transient events will be a critical issue in ITER. A new ITER-like wide-angle infrared and visible diagnostic, allowing to observe plasma wall interaction in the main chamber, has been installed on JET. The design and the manufacture of the diagnostic

  5. Diagnostics of D.C. Starter Generators While Using Fuzzy Logic Theory

    Directory of Open Access Journals (Sweden)

    A. A. Lobaty

    2011-01-01

    Full Text Available Methodology for sparking control in generator brush contact has been developed on the basis of the proposed fuzzy diagnostic model for ad.c.starter-generator and complex processing of diagnostic data. The paper provides investigation results, namely: dependence of voltage parameters  in an external generator circuit on collector sparking intensity.

  6. ITER-like wide-angle infrared thermography and visible observation diagnostic using reflective optics

    NARCIS (Netherlands)

    Gauthier, E.; Roche, H.; Thomas, E.; Droineau, S.; Bertrand, B.; Migozzi, J.B.; Vliegenthart, W.A.; Dague, L.; Andrew, P.; Tiscornia, T.; Sands, D.

    2007-01-01

    Control of the plasma-wall interaction during transient events will be a critical issue in ITER. A new ITER-like wide-angle infrared and visible diagnostic, allowing to observe plasma wall interaction in the main chamber, has been installed on JET. The design and the manufacture of the diagnostic an

  7. Diagnostic Validity of the Luria-Nebraska Neuropsychological Battery-Children's Revision.

    Science.gov (United States)

    Carr, Margaret A.; And Others

    1986-01-01

    Results of an assessment of the diagnostic validity of the Luria-Nebraska Neuropsychological Battery-Children's Revision (LNNB-C) with the Wechsler Intelligence Scale for Children-Revised (WISC-R) for the following relevant diagnostic groups: neurological, psychiatric, and normal controls are reported. (Author/BL)

  8. Diagnostic Validity of the Luria-Nebraska Neuropsychological Battery-Children's Revision.

    Science.gov (United States)

    Carr, Margaret A.; And Others

    1986-01-01

    Results of an assessment of the diagnostic validity of the Luria-Nebraska Neuropsychological Battery-Children's Revision (LNNB-C) with the Wechsler Intelligence Scale for Children-Revised (WISC-R) for the following relevant diagnostic groups: neurological, psychiatric, and normal controls are reported. (Author/BL)

  9. Diagnostic tools for studying divertor detachment: bolometry, spectroscopy, and thermography for surface heat-flux

    Science.gov (United States)

    Terry, J. L.; Reinke, M. L.

    2017-04-01

    Some of the key aspects of divertor detachment that are addressed by bolometry, impurity spectroscopy, hydrogen spectroscopy, and measurements of divertor target heat-flux are reviewed. Measurement requirements for these diagnostic areas are defined, and brief descriptions of the techniques used for these diagnostics are given. Examples from the literature of measurements using these tools applied to detachment are presented. Feedback control of detachment using some of these diagnostics as the ‘sensors’ is reviewed. Challenges and some future directions for these diagnostics in the context of studying divertor detachment are described.

  10. Borderline Ovarian Tumors and Diagnostic Dilemma of Intraoperative Diagnosis: Could Preoperative He4 Assay and ROMA Score Assessment Increase the Frozen Section Accuracy? A Multicenter Case-Control Study

    Directory of Open Access Journals (Sweden)

    Salvatore Gizzo

    2014-01-01

    Full Text Available The aim of our study was to assess the value of a preoperative He4-serum-assay and ROMA-score assessment in improving the accuracy of frozen section histology in the diagnosis of borderline ovarian tumors (BOT. 113 women presenting with a unilateral ovarian mass diagnosed as serous/mucinous BOT at frozen-section-histology (FS and/or confirmed on final pathology were recruited. Pathologists were informed of the results of preoperative clinical/instrumental assessment of all patients. For Group_A patients, additional information regarding He4, CA125, and ROMA score was available (in Group_B only CA125 was known. The comparison between Group A and Group B in terms of FS accuracy, demonstrated a consensual diagnosis in 62.8% versus 58.6% (P: n.s., underdiagnosis in 25.6% versus 41.4% (P<0.05, and overdiagnosis in 11.6% versus 0% (P<0.01. Low FS diagnostic accuracy was associated with menopausal status (OR: 2.13, laparoscopic approach (OR: 2.18, mucinous histotype (OR: 2.23, low grading (OR: 1.30, and FIGO stage I (OR: 2.53. Ultrasound detection of papillae (OR: 0.29, septa (OR: 0.39, atypical vascularization (OR: 0.34, serum He4 assay (OR: 0.39, and ROMA score assessment (OR: 0.44 decreased the probability of underdiagnosis. A combined preoperative assessment through serum markers and ultrasonographic features may potentially reduce the risk of underdiagnosis of BOTs on FS while likely increasing the concomitant incidence of false-positive events.

  11. Diagnostics of Pupils' Attitude to Education

    Science.gov (United States)

    Eminli, Tovuz

    2011-01-01

    The paper is devoted to the investigation of the questions connected with the pedagogical diagnostics, in particular, the diagnostics of pupils' attitude to education. It is considered reasonable to apply the practice of development of an individual pedagogical and psychological map for productive implementation of the pedagogical diagnostics and…

  12. Diagnostic accuracy of the care dependency scale

    NARCIS (Netherlands)

    Dijkstra, Ate; Tiesinga, LJ; Plantinga, L; Dassen, TWN; Veltman, G.

    2005-01-01

    Aim. This paper reports an investigation of the diagnostic accuracy of the Care Dependency Scale (CDS). Background. Assessment tools can be described in terms of diagnostic accuracy, or the ability to correctly classify subjects into clinically relevant subgroups. Diagnostic accuracy can be determin

  13. Drug resistant tuberculosis: A diagnostic challenge

    Directory of Open Access Journals (Sweden)

    M Dash

    2013-01-01

    Full Text Available Tuberculosis (TB is responsible for 1.4 million deaths annually. Wide-spread misuse of anti-tubercular drugs over three decades has resulted in emergence of drug resistant TB including multidrug-resistant TB and extensively drug-resistant TB globally. Accurate and rapid diagnosis of drug-resistant TB is one of the paramount importance for instituting appropriate clinical management and infection control measures. The present article provides an overview of the various diagnostic options available for drug resistant TB, by searching PubMed for recent articles. Rapid phenotypic tests still requires days to weeks to obtain final results, requiring biosafety and quality control measures. For newly developed molecular methods, infrastructure, training and quality assurance should be followed. Successful control of drug resistant TB globally will depend upon strengthening TB control programs, wider access to rapid diagnosis and provision of effective treatment. Therefore, political and fund provider commitment is essential to curb the spread of drug resistant TB.

  14. A diagnostic system for high-voltage electrical components

    Energy Technology Data Exchange (ETDEWEB)

    Masetti, C.

    1988-10-01

    This paper presents an example, indicating system logic and architecture, of a centralized diagnostic system for a modern substation. Detail are provided of the part relevant to the most important functions and operations required: measurements and transduction; local signal transmission, data acquisition and possible display; remote signal transmission; central processing, interpretation and decision-making. The diagnostic system in this case was designed to control a number of power transformers of a utility or large industrial user operating on a regional scale: the example can be extended in a modular way to include also the monitoring of other components (GIS, circuit breakers, arresters, etc.), or of more stations of a larger national network. The diagnostic system envisaged is thus flexible, with respect to the different functions required to solve, and modular, so that it can be integrated and expanded gradually as one pleases.

  15. Final design of thermal diagnostic system in SPIDER ion source

    Science.gov (United States)

    Brombin, M.; Dalla Palma, M.; Pasqualotto, R.; Pomaro, N.

    2016-11-01

    The prototype radio frequency source of the ITER heating neutral beams will be first tested in SPIDER test facility to optimize H- production, cesium dynamics, and overall plasma characteristics. Several diagnostics will allow to fully characterise the beam in terms of uniformity and divergence and the source, besides supporting a safe and controlled operation. In particular, thermal measurements will be used for beam monitoring and system protection. SPIDER will be instrumented with mineral insulated cable thermocouples, both on the grids, on other components of the beam source, and on the rear side of the beam dump water cooled elements. This paper deals with the final design and the technical specification of the thermal sensor diagnostic for SPIDER. In particular the layout of the diagnostic, together with the sensors distribution in the different components, the cables routing and the conditioning and acquisition cubicles are described.

  16. Final design of thermal diagnostic system in SPIDER ion source

    Energy Technology Data Exchange (ETDEWEB)

    Brombin, M., E-mail: matteo.brombin@igi.cnr.it; Dalla Palma, M.; Pasqualotto, R.; Pomaro, N. [Consorzio RFX, Corso Stati Uniti 4, I-35127 Padova (Italy)

    2016-11-15

    The prototype radio frequency source of the ITER heating neutral beams will be first tested in SPIDER test facility to optimize H{sup −} production, cesium dynamics, and overall plasma characteristics. Several diagnostics will allow to fully characterise the beam in terms of uniformity and divergence and the source, besides supporting a safe and controlled operation. In particular, thermal measurements will be used for beam monitoring and system protection. SPIDER will be instrumented with mineral insulated cable thermocouples, both on the grids, on other components of the beam source, and on the rear side of the beam dump water cooled elements. This paper deals with the final design and the technical specification of the thermal sensor diagnostic for SPIDER. In particular the layout of the diagnostic, together with the sensors distribution in the different components, the cables routing and the conditioning and acquisition cubicles are described.

  17. Inferences of clinical diagnostic reasoning and diagnostic error.

    Science.gov (United States)

    Lawson, Anton E; Daniel, Erno S

    2011-06-01

    This paper discusses clinical diagnostic reasoning in terms of a pattern of If/then/Therefore reasoning driven by data gathering and the inference of abduction, as defined in the present paper, and the inferences of retroduction, deduction, and induction as defined by philosopher Charles Sanders Peirce. The complex inferential reasoning driving clinical diagnosis often takes place subconsciously and so rapidly that its nature remains largely hidden from the diagnostician. Nevertheless, we propose that raising such reasoning to the conscious level reveals not its basic pattern and basic inferences, it also reveals where errors can and do occur and how such errors might be reduced or even eliminated.

  18. 基于红外条码的盲人扑克游戏辅助仪的设计%Design and implementation of blind poker game auxiliary instrument based on infrared scanning bar code

    Institute of Scientific and Technical Information of China (English)

    景亚霓; 杨海平

    2014-01-01

    The paper designs a blind poker game auxiliary instrument based on bar code technology, embedded system and voice chip technology. The instrument has the characteristics of compact structure , simple and convenient operation and embed popular poker game program, thus users can conveniently select the type of game according to their interest. Its main feature is that it can broadcast information that others played poker and supplies situation of yourself poker in hands by earplug if need. The auxiliary instrument makes the blind to get poke information by "listen" instead of "touch", so that blind and low vision people can play cards as a normal person even if he does not know Braille. In other hand, some problem can be avoided, such as mistake of player distinguishing Braille.%设计了一款基于集条形码技术、嵌入式系统及语音芯片技术于一体、结构紧凑、操作简单方便的盲人扑克游戏辅助仪。该装置设计了常见的扑克游戏程序,使用者可根据兴趣方便地选择游戏种类。其主要特点是利用语音技术能够实时播报其他人的出牌信息并可根据需要耳机播报本人手中牌的信息,让盲人用“听”牌代替了“摸”牌,使盲人以及不懂盲文的低视力人群能像正常人一样打扑克、玩桥牌等,克服了现有低视力群体打牌游戏中常见的问题,如盲文识别错误等。

  19. Beam diagnostic suite for the SNS linac

    Science.gov (United States)

    Hardekopf, R. A.; Kurennoy, S. S.; Power, J. F.; Shafer, R. E.; Stovall, J. E.

    2000-11-01

    The Spallation Neutron Source (SNS) is the next-generation pulsed neutron source to be built in the United States. The accelerator chosen to produce the 2 MW beam power on the neutron-producing target is an H- linear accelerator (linac) to 1 GeV, followed by a proton accumulator ring. The ring compresses the 1 ms long beam bunches from the linac to less than 1 μs. The linac is pulsed at 60 Hz with a 6% duty factor. Stringent control of the pulse structure and stability of the high-intensity H- beam is needed to minimize beam loss in the linac and to optimize injection into the accumulator ring. This requires a set of beam diagnostics that can operate at high peak currents (˜52 mA) with high sensitivity and minimum beam interception.

  20. Recombinant protein-based viral disease diagnostics in veterinary medicine.

    Science.gov (United States)

    Balamurugan, Vinayagamurthy; Venkatesan, Gnanavel; Sen, Arnab; Annamalai, Lakshmanan; Bhanuprakash, Veerakyathappa; Singh, Raj Kumar

    2010-09-01

    Identification of pathogens or antibody response to pathogens in human and animals modulates the treatment strategies for naive population and subsequent infections. Diseases can be controlled and even eradicated based on the epidemiology and effective prophylaxis, which often depends on development of efficient diagnostics. In addition, combating newly emerging diseases in human as well as animal healthcare is challenging and is dependent on developing safe and efficient diagnostics. Detection of antibodies directed against specific antigens has been the method of choice for documenting prior infection. Other than zoonosis, development of inexpensive vaccines and diagnostics is a unique problem in animal healthcare. The advent of recombinant DNA technology and its application in the biotechnology industry has revolutionized animal healthcare. The use of recombinant DNA technology in animal disease diagnosis has improved the rapidity, specificity and sensitivity of various diagnostic assays. This is because of the absence of host cellular proteins in the recombinant derived antigen preparations that dramatically decrease the rate of false-positive reactions. Various recombinant products are used for disease diagnosis in veterinary medicine and this article discusses recombinant-based viral disease diagnostics currently used for detection of pathogens in livestock and poultry.