Effect of length of productive life on genetic trend of milk production ...

African Journals Online (AJOL)

Longevity is an important economic trait in dairy cattle. Including this trait in a breeding scheme, increases profit. The aim of this study was to evaluate the relationship between length of productive life (LPL), genetic trend of milk production and profitability of herds. LPL has been defined as time from first calving to culling.

Estimates of phenotypic and genetic trends of growth traits in N ...

African Journals Online (AJOL)

... 0.18±0.06kg/yr and -0.005 ±0.003kglyr for BTHWT, ADWNWT and ADG respectively. In contrast, all estimated genetic trends were relatively small and not significantly different from zero. They were 0.02±0.05kg/yr, 0.02±0.05kg/yr and 0.1g/yr for BTHWT, ADWNWT and ADG respectively. The sequential polynomial fitting of ...

The behavioural genetics of personality development in adulthood-classic, contemporary, and future trends

NARCIS (Netherlands)

Bleidorn, Wiebke; Kandler, Christian; Caspi, Avshalom

2014-01-01

Behavioural genetic research has led to important advances in the field of personality psychology. When carried out on longitudinal data, behavioural genetic studies also offer promising ways to examine the genetic and environmental origins of personality stability and change. Here, we review the

Evaluation of mature cow weight: genetic correlations with traits used in selection indices, correlated responses, and genetic trends in Nelore cattle.

Science.gov (United States)

Boligon, A A; Carvalheiro, R; Albuquerque, L G

2013-01-01

Genetic correlations of selection indices and the traits considered in these indices with mature weight (MW) of Nelore females and correlated responses were estimated to determine whether current selection practices will result in an undesired correlated response in MW. Genetic trends for weaning and yearling indices and MW were also estimated. Data from 612,244 Nelore animals born between 1984 and 2010, belonging to different beef cattle evaluation programs from Brazil and Paraguay, were used. The following traits were studied: weaning conformation (WC), weaning precocity (WP), weaning muscling (WM), yearling conformation (YC), yearling precocity (YP), yearling muscling (YM), weaning and yearling indices, BW gain from birth to weaning (BWG), postweaning BW gain (PWG), scrotal circumference (SC), and MW. The variance and covariance components were estimated by Bayesian inference in a multitrait analysis, including all traits in the same analysis, using a nonlinear (threshold) animal model for visual scores and a linear animal model for the other traits. The mean direct heritabilities were 0.21±0.007 (WC), 0.22±0.007 (WP), 0.20±0.007 (WM), 0.43±0.005 (YC), 0.40±0.005 (YP), 0.40±0.005 (YM), 0.17±0.003 (BWG), 0.21±0.004 (PWG), 0.32±0.001 (SC), and 0.44±0.018 (MW). The genetic correlations between MW and weaning and yearling indices were positive and of medium magnitude (0.30±0.01 and 0.31±0.01, respectively). The genetic changes in weaning index, yearling index, and MW, expressed as units of genetic SD per year, were 0.26, 0.27, and 0.01, respectively. The genetic trend for MW was nonsignificant, suggesting no negative correlated response. The selection practice based on the use of sires with high final index giving preference for those better ranked for yearling precocity and muscling than for conformation generates only a minimal correlated response in MW.

Trends in population-based studies of human genetics in infectious diseases.

Science.gov (United States)

Rowell, Jessica L; Dowling, Nicole F; Yu, Wei; Yesupriya, Ajay; Zhang, Lyna; Gwinn, Marta

2012-01-01

Pathogen genetics is already a mainstay of public health investigation and control efforts; now advances in technology make it possible to investigate the role of human genetic variation in the epidemiology of infectious diseases. To describe trends in this field, we analyzed articles that were published from 2001 through 2010 and indexed by the HuGE Navigator, a curated online database of PubMed abstracts in human genome epidemiology. We extracted the principal findings from all meta-analyses and genome-wide association studies (GWAS) with an infectious disease-related outcome. Finally, we compared the representation of diseases in HuGE Navigator with their contributions to morbidity worldwide. We identified 3,730 articles on infectious diseases, including 27 meta-analyses and 23 GWAS. The number published each year increased from 148 in 2001 to 543 in 2010 but remained a small fraction (about 7%) of all studies in human genome epidemiology. Most articles were by authors from developed countries, but the percentage by authors from resource-limited countries increased from 9% to 25% during the period studied. The most commonly studied diseases were HIV/AIDS, tuberculosis, hepatitis B infection, hepatitis C infection, sepsis, and malaria. As genomic research methods become more affordable and accessible, population-based research on infectious diseases will be able to examine the role of variation in human as well as pathogen genomes. This approach offers new opportunities for understanding infectious disease susceptibility, severity, treatment, control, and prevention.

Trends in Mobile Application Development

Science.gov (United States)

Holzer, Adrian; Ondrus, Jan

Major software companies, such as Apple and Google, are disturbing the relatively safe and established actors of the mobile application business. These newcomers have caused significant structural changes by imposing and enforcing their own rules for the future of mobile application development. The implications of these changes do not only concern the mobile network operators and mobile phone manufacturers. This changed environment also brings additional opportunities and constraints for current mobile application developers. Therefore, developers need to assess what their options are and how they can take advantages of these current trends. In this paper, we take a developer’s perspective in order to explore how the structural changes will influence the mobile application development markets. Moreover, we discuss what aspects developers need to take into account in order to position themselves within the current trends.

Diallel crossing in Pinus cembra: IV. age trends in genetic parameters and genetic gain for growth and branching traits

Directory of Open Access Journals (Sweden)

Ioan Blada

2013-12-01

Full Text Available This paper reports results from a complete 10 x 10 diallel carried out in a natural population of Swiss stone pine (Pinus cembra L. from the southern Carpathian Mountains. At age six, after nursery testing, the material was field planted on one site, using a completely randomized block design with 100 families, four replicates and 15 tree row-plots per replication, spaced 2.5 x 2.5m. Total and annual height growth, root collar diameter, number of branches per whorl and survival were assessed at successive ages between ages eight and 14 after seed. In addition, several traits that were assessed during the nursery test were used in correlation and some other analyses. Plot means of the measured traits were analyzed using the general least-squares method by means of the computer DIALL programme prepared by Schaffer and Usanis (1969. Across the field testing periods, significant (p<0.05 and highly significant (p<0.01; p<0.001 differences occurred in total height growth and root collar diameter for general and specific combining ability as well for maternalinteraction effects. These results suggest that the traits are controlled by nuclear (additive and non-additive and by nuclear x extra-nuclear gene interactions. In an ascendant trend, the additive variance, as a percent of the total genetic variance, ranged from 35% at age eight to 66% at age 14 for total height growth, while that for root collar diameter trend varied less between 16% and 34%. In a descendant trend, the dominance ratios s2SCA/ s2GCA for total height growth ranged from 0.9 at age eight to 0.3 at age 14, suggesting that the additive variance should be used in the breeding programme. Parents with significant general combining effects for all but one trait were found. For total height growth, the narrow-sense family mean heritability estimates varied in an ascendant trend between 0.45 and 0.65 while the narrow- sense individual tree heritability varied irregularly from year to year

Training future physicians in the era of genomic medicine: trends in undergraduate medical genetics education.

Science.gov (United States)

Plunkett-Rondeau, Jevon; Hyland, Katherine; Dasgupta, Shoumita

2015-11-01

Advances in genomic technologies are transforming medical practice, necessitating the expertise of genomically-literate physicians. This study examined 2013-2014 trends in genetics curricula in US and Canadian medical schools to ascertain whether and how curricula are keeping pace with this rapid evolution. Medical genetics course directors received a 60-item electronic questionnaire covering curriculum design, assessment, remediation of failing grades, and inclusion of specific topics. The response rate was 74%. Most schools teach the majority of genetics during the first 2 years, with an increase in the number of integrated curricula. Only 26% reported formal genetics teaching during years 3 and 4, and most respondents felt the amount of time spent on genetics was insufficient preparation for clinical practice. Most participants are using the Association of Professors of Human and Medical Genetics Core Curriculum(1) as a guide. Topics recently added include personalized medicine (21%) and direct-to-consumer testing (18%), whereas eugenics (17%), linkage analysis (16%), and evolutionary genetics (15%) have been recently eliminated. Remediation strategies were heterogeneous across institutions. These findings provide an important update on how genetics and genomics is taught at US and Canadian medical schools. Continuous improvement of educational initiatives will aid in producing genomically-literate physicians.

Genetic trend for growth and wool performance in a closed flock of Bharat Merino sheep at sub temperate region of Kodai hills, Tamil Nadu.

Science.gov (United States)

Mallick, P K; Thirumaran, S M K; Pourouchottamane, R; Rajapandi, S; Venkataramanan, R; Nagarajan, G; Murali, G; Rajendiran, A S

2016-03-01

The study was conducted at Southern Regional Research Center, ICAR-Central Sheep and Wool Research Institute (CSWRI), Mannavanur, Kodaikanal, Tamil Nadu to estimate genetic trends for birth weight (BWT), weaning weight (3WT), 6 months weight (6WT), and greasy fleece weight (GFY) in a Bharat Merino (BM) flock, where selection was practiced for 6WT and GFY. The data for this study represents a total of 1652 BM lambs; progeny of 144 sires spread over 15 years starting from 2000 to 2014, obtained from the BM flock of ICAR-SRRC (CSWRI), Mannavanur, Kodaikanal, Tamil Nadu, India. The genetic trends were calculated by regression of average predicted breeding values using software WOMBAT for the traits BWT, 3WT, 6WT and GFY versus the animal's birth year. The least square means were 3.28±0.02 kg, 19.08±0.23 kg, 25.00±0.35 kg and 2.13±0.07 kg for BWT, 3WT, 6WT and GFY, respectively. Genetic trends were positive and highly significant (p<0.01) for BWT, while the values for 3WT, 6WT and GFY though positive, were not significant. The estimates of genetic trends in BWT, 3WT, 6WT and GFY were 5 g, 0.8 g, 7 g and 0.3 g/year gain and the fit of the regression shows 55%, 22%, 42% and 12% coefficient of determination with the regressed value, respectively. In this study, estimated mean predicted breeding value (kg) in BWT and 3WT, 6WT and GFY were 0.067, 0.008, 0.036 and -0.003, respectively. Estimates of genetic trends indicated that there was a positive genetic improvement in all studied traits and selection would be effective for the improvement of body weight traits and GFY of BM sheep.

Trends for Innovation Business Development in Lviv Region

OpenAIRE

Tetyana Skrypko

2014-01-01

The Articles highlights trends of small business innovation development at a regional level. Small business innovation structure has been analyzed for Lviv region; interactive procedures have been researched referring to cooperation between the parties interested in its development. The amount of innovation-active small businesses and the number of innovations introduced in Lviv region have been mentioned by innovation trends and types of economic activity. Up-to-date trends in Lviv region co...

Applications and development trend of radiopharmaceuticals

International Nuclear Information System (INIS)

Kim, J.R.

1978-01-01

Present status of radiopharmaceuticals applications and the trend of the development are extensively reviewed and discussed. The followings are manifested: a) Among the various radionuclides, those of short lived, accelerator produced, and having moderate radiation energies are becoming popular. b) Diagnosis using various labelled molecules are considered to be the most active field in nuclear medicine. c) Development of radiopharmaceuticals for tumor localization studies is one of the trends. d) The use of various convenient kits of both in-vitro radioligand assay, and in-vivo instant labelling is now an enormous domain in nuclear medicine. A great stride is also made in the development of automation technique. Upon it, an urgent development of some new radiopharmaceuticals having local characteristics is proposed. (author)

Laser Cutting, Development Trends

DEFF Research Database (Denmark)

Olsen, Flemming Ove

1999-01-01

In this paper a short review of the development trends in laser cutting will be given.The technology, which is the fastest expanding industrial production technology will develop in both its core market segment: Flat bed cutting of sheet metal, as it will expand in heavy industry and in cutting...... of 3-dimensional shapes.The CO2-laser will also in the near future be the dominating laser source in the market, although the new developments in ND-YAG-lasers opens for new possibilities for this laser type....

Genetic parameters and trends of morphometric traits of GIFT tilapia under selection for weight gain

Directory of Open Access Journals (Sweden)

Rafael Vilhena Reis Neto

2014-08-01

Full Text Available The main factor considered in breeding programs for fish is growth, which can be assessed in terms of a gain in either weight or body measurements. This study was undertaken to evaluate the morphometric traits of GIFT strain tilapia (Oreochromis sp. selected for weight gain. The data set used contained information on 6,650 animals. The genetic values of 8,590 animals in a relationship matrix of five generations were predicted. The following morphometric measurements were evaluated: standard length; body depth and body width. Body area and volume were also calculated. Bi-character analyses involving morphometric traits were used to estimate (covariance components. Heritability, larval and fingerling common environmental effects were estimated for each trait, together with the genetic and phenotypic correlations between traits. Bayesian procedures were utilised by Gibbs chains, and the convergence of the chains was tested using the Heidelberger and Welch method. Genetic trends were estimated by segmented regression of the fish breeding values of the generations considered in this study. Estimates of heritability (0.28 a 0.31 had moderate to high magnitudes for all traits. Genetic correlations between traits were all above 0.8, and the genetic gains were satisfactory from the third generation onwards. From the estimates of the genetic parameters and genetic gain the morphometric traits evaluated have good potential for selection.

Association of education & lifestyle factors with the perception of genetic knowledge on the development of lung cancer

Directory of Open Access Journals (Sweden)

Liang Wang

2016-01-01

Full Text Available Background & objectives: The perception of genetic knowledge is useful for improving the heath behaviour change against developing cancers. However, no studies have investigated the perception of genetic knowledge on the development of lung cancer. The aim of this study was to examine demographic and lifestyle factors of the perception of genetic knowledge on the development of lung cancer. Methods: Data on 2,295 US adults (739 had the perception of genetic knowledge were taken from the 2003 Health Information National Trends Survey. Multiple logistic regression models were used to evaluate potential factors of the perception of genetic knowledge of lung cancer. Results: Participants aged ≥65 yr were more likely to have the perception of genetic knowledge than those aged 18-44 yr (OR=1.77, 95% CI=1.27-2.46. Higher education was associated with a greater perception of genetic knowledge (OR=1.47, 95% CI=1.16-1.87. Subjects with correct smoking attitude were more than three times more likely to have the perception of genetic knowledge (OR=3.15, 95% CI=2.10-4.72. Subjects with exercise were at an increased likelihood of having the perception of genetic knowledge than those without exercise (OR=1.63, 95% CI=1.24-2.13. Interpretation & conclusions: Positive associations were observed between education and lifestyle factors and the perception of genetic knowledge on the development of lung cancer among US adults. Strategies developed to improve the perception of genetic knowledge of lung cancer may target on individuals who are young, less educated, and lack correct smoking attitude or exercise.

Trends in the development of the Danish universities

DEFF Research Database (Denmark)

Sarauw, Laura Louise; Christiansen, Niels Frederik Voetmann; Harboe, Thomas

2015-01-01

The chapter outlines some important development trends in the way universities, globally as well as nationally in terms of organisation, research, education and teaching.......The chapter outlines some important development trends in the way universities, globally as well as nationally in terms of organisation, research, education and teaching....

Trends and Gaps in Awareness of Direct-to-Consumer Genetic Tests From 2007 to 2014.

Science.gov (United States)

Apathy, Nate C; Menser, Terri; Keeran, Lindsay M; Ford, Eric W; Harle, Christopher A; Huerta, Timothy R

2018-06-01

Direct-to-consumer genetic tests for inherited disease risks have gained recent approvals from the Food and Drug Administration, and interest in these tests has continued to grow. Broad use of these tests coupled with planning and discussion with health providers regarding genetic risks and potential protective behavior changes have been proposed as preventive tools to reduce health disparities and improve equity in health outcomes. However, awareness of direct-to-consumer genetic testing has historically demonstrated differences by education, income, and race; these disparities could jeopardize potential benefits by limiting access and use. The national survey data from the Health Information National Trends Survey was analyzed to understand how overall awareness of direct-to-consumer genetic testing and disparities in awareness across sociodemographic groups have changed since 2007. The findings showed persistent disparities, as well as a widening gap in awareness between Hispanics and non-Hispanic whites (OR 2007 =1.52, OR 2014 =0.58, p change =0.0056), despite overall increases in awareness over time. Given these findings, policies regulating direct-to-consumer genetic tests should prioritize equitable distribution of benefits by including provisions that counteract prevailing disparities in awareness. Copyright © 2018 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Genetic trends in the expected progeny difference of the asymptotic weight of Nelore females

Directory of Open Access Journals (Sweden)

Analía del Valle Garnero

2006-01-01

Full Text Available There are few studies on weight covering the full life cycle of Zebu cattle, and there is no entire growth description or mean growth pattern for animals belonging to this breed. In order to provide such data, 1,158 Nelore females born between 1985 and 1995 were weighed 14,563 times from birth to full growth maturity, in ten herds spread over seven Brazilian states. The Von Bertalanffy, Brody, logistic and Gompertz non-linear models were used to obtain the asymptotic weights (A and the maturation rates (K. The (covariance and breeding value components for A and K were obtained by using the multiple trait derivative free restricted maximum likelihood method under the animal model. Genetic trends were calculated in function of the mean expected progeny differences (EPD for the trait (A or K divided by the number of animals according to their year of birth. The genetic trends of the expected progeny difference with reference to the date of birth of the cows were, on average, -6.5g y-1 for A and 2.0g y-1 for K, close to zero as confirmed by the low (0.0023 to 0.003 coefficient of regression values. The curve parameters are recommended as a selection criterion to reach precocity and avoid adult weight increase in the female herd.

Medical Genetics and the First Studies of the Genetics of Populations in Mexico.

Science.gov (United States)

Barahona, Ana

2016-09-01

Following World War II (WWII), there was a new emphasis within genetics on studying the genetic composition of populations. This probably had a dual source in the growing strength of evolutionary biology and the new international interest in understanding the effects of radiation on human populations, following the atomic bombings in Japan. These global concerns were shared by Mexican physicians. Indeed, Mexico was one of the leading centers of this trend in human genetics. Three leading players in this story were Mario Salazar Mallén, Adolfo Karl, and Rubén Lisker. Their trajectories and the international networks in human genetics that were established after WWII, paved the way for the establishment of medical and population genetics in Mexico. Salazar Mallén's studies on the distribution and characterization of ABO blood groups in indigenous populations were the starting point while Karl's studies on the distribution of abnormal hemoglobin in Mexican indigenous populations showed the relationships observed in other laboratories at the time. It was Lisker's studies, however, that were instrumental in the development of population genetics in the context of national public policies for extending health care services to the Mexican population. In particular, he conducted studies on Mexican indigenous groups contributing to the knowledge of the biological diversity of human populations according to international trends that focused on the variability of human populations in terms of genetic frequencies. From the start, however, Lisker was as committed to the reconstruction of shared languages and practices as he was to building networks of collaboration in order to guarantee the necessary groundwork for establishing the study of the genetics of human populations in Mexico. This study also allows us to place Mexican science within a global context in which connected narratives describe the interplay between global trends and national contexts. Copyright © 2016 by

Problems of genetic diagnosis: serological markers in the prognosis of the development of human speed abilities

Directory of Open Access Journals (Sweden)

Serhiyenko Leonid Prokopovich

2011-10-01

Full Text Available The article deals with the study of correlation between blood groups system AB0 and Rh with the peculiarities of the development of human speed abilities. Complex of genetic markers is defined. It is possible to use this complex in the individual prognosis of the development of human motor abilities. With 0(I and A(II blood groups and Rh+ have a high inclination to the physical development. Better identify trends in the phenotypic expression of high-speed abilities in people with 0(I and A(II blood groups in comparison with people with the AB(IV and B(III blood group. The pattern of decreasing susceptibility to the development of high-speed abilities as follows: 0(I>A(II>B(III>AB (IV. It is established that a complex system of genetic markers AB0 and Rh blood has no gender differences.

Assessing Genetic Literacy Awareness and Knowledge Gaps in the US Population: Results from the Health Information National Trends Survey.

Science.gov (United States)

Krakow, Melinda; Ratcliff, Chelsea L; Hesse, Bradford W; Greenberg-Worisek, Alexandra J

2018-05-31

Public understanding of the role of genetics in disease risk is key to appropriate disease prevention and detection. This study assessed the current extent of awareness and use of genetic testing in the US population. Additionally, the study identified characteristics of subgroups more likely to be at risk for low genetic literacy. The study used data from the National Cancer Institute's 2017 Health Information National Trends Survey, including measures of genetic testing awareness, genetic testing applications and genetic testing usage. Multivariable logistic regression models estimated associations between sociodemographics, genetic testing awareness, and genetic testing use. Fifty-seven percent of respondents were aware of genetic tests. Testing awareness differed by age, household income, and race/ethnicity. Most participants had heard of using tests to determine personal disease risk (82.58%) or inherited disease risk in children (81.41%), but less were familiar with determining treatment (38.29%) or drug efficacy (40.76%). Among those with genetic testing awareness, actual testing uptake was low. A large portion of the general public lacks genetic testing awareness and may benefit from educational campaigns. As precision medicine expands, increasing public awareness about genetic testing applications for disease prevention and treatment will be important to support population health. This is a work of the US Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. Published by S. Karger AG, Basel.

Global trends on fears and concerns of genetic discrimination: a systematic literature review.

Science.gov (United States)

Wauters, Annet; Van Hoyweghen, Ine

2016-04-01

Since the 1990s, developments in the field of genetics have led to many questions on the use and possible misuse of genetic information. 'Genetic discrimination' has been defined as the differential treatment of asymptomatic individuals or their relatives on the basis of their real or assumed genetic characteristics. Despite the public policy attention around genetic discrimination, there is currently still much confusion surrounding this phenomenon. On the one hand, there is little evidence of the occurrence of genetic discrimination. On the other hand, it appears that people remain concerned about this theme, and this fear influences their health and life choices. This article makes use of a systematic literature review to investigate what is already known about the nature, extent and background of these fears and concerns. The 42 included studies have found considerable levels of concerns about genetic discrimination. Concerns dominate in insurance contexts and within personal interactions. The extent of concerns appears to vary depending on the type of genetic illness. Furthermore, installed laws prohibiting genetic discrimination do not seem to alleviate existing fears. This raises important questions as to the origins of these fears. Based on the findings, recommendations for future research are made. First, research on the background of fears is needed. Second, future research needs to assess more fully all different forms (for example, direct and indirect) of genetic discrimination. Thirdly, it has to be studied whether genetic discrimination is a form of discrimination that is distinguishable from discrimination based on an illness or disability. Finally, a last element that should be addressed in future research is the most recent developments in research on genomics, such as next-generation sequencing or genome-wide association studies.

Global health care leadership development: trends to consider

Directory of Open Access Journals (Sweden)

MacPhee M

2013-06-01

Full Text Available Maura MacPhee,1 Lilu Chang,2 Diana Lee,3 Wilza Spiri4 1University of British Columbia School of Nursing, Vancouver, British Columbia, Canada; 2Center for Advancement of Nursing Education, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan; 3Nethersole School of Nursing, Chinese University of Hong Kong, Hong Kong, 4São Paulo State University, Botucatu, São Paulo, Brazil Abstract: This paper provides an overview of trends associated with global health care leadership development. Accompanying these trends are propositions based on current available evidence. These testable propositions should be considered when designing, implementing, and evaluating global health care leadership development models and programs. One particular leadership development model, a multilevel identity model, is presented as a potential model to use for leadership development. Other, complementary approaches, such as positive psychology and empowerment strategies, are discussed in relation to leadership identity formation. Specific issues related to global leadership are reviewed, including cultural intelligence and global mindset. An example is given of a nurse leadership development model that has been empirically tested in Canada. Through formal practice–academic–community collaborations, this model has been locally adapted and is being used for nurse leader training in Hong Kong, Taiwan, and Brazil. Collaborative work is under way to adapt the model for interprofessional health care leadership development. Keywords: health care leadership, development models, global trends, collective

New trends in RFQ-development

International Nuclear Information System (INIS)

Schempp, A.

1987-01-01

New trends in RFQ-development depending on the design goals are presented. Designs for heavy ion RFQs and for highly charged light ions from EBIS source are given. The use of the RFQ to accelerate beams, to accelerate very heavy clusters is shown. The application of the procedure funnel beams with RFQs is outlined. The beam dynamic parameters of the 4-vane RFQ for HERA are given

Advertising practice in Nigeria: Development, new trends ...

African Journals Online (AJOL)

Advertising practice in Nigeria: Development, new trends, challenges and prospects. ... include the practice of Integrated Marketing Communications (IMC); which is ... promotions, events marketing, etc, in carrying out a promotional campaign.

Genetic technology and agricultural development.

Science.gov (United States)

Staub, W J; Blase, M G

1971-07-09

The genetic technologies being adopted in South Asia are significant factors in the agricultural development of the area. But, labeling them " miracle seeds," solely responsible for recent agricultural growth, is misleading. Certainly the introduction of new genetic technology has catalyzed South Asian agriculture and has instilled a new dynamism essential to economic development. Somewhat similar phenomena have, however, been observed in other parts of the world in other periods of history. The nature of these genetic technologies, how they are being applied, and their limits and potential have been explored above. Also, the effects of these varieties on the generation of employment, and the distribution of benefits accruing from them have been examined in preliminary fashion. Stemming from the preceding discussion, two areas of priority appear obvious. First, the close association of genetic technologies with irrigation suggests that irrigation should receive more attention than it has in the past. Large-scale public irrigation schemes are expensive and have tended to yield low rates of return. However, there appears to be room for marginal increases in, or improvements of, existing irrigation facilities. Second, even with a rapid spread of the practices associated with highyeild varieties, it may be too much to expect the farm sector to absorb the expected increases in the rural labor force. The generation of employment is a major problem in India as well as in most other developing countries. Hence, possibilities for expanding rural, nonfarm employment and controlling population growth should be sought vigorously.

Analysis of Development Environment and Development Trend of Chinese Tourism

Science.gov (United States)

Zhao, Liyun; Li, Lingzhi

2018-01-01

Since the reform and opening up of Chinese tourism industry, the scale has been continuously expanded and the income from tourism has been continuously increasing. Chinese tourism industry has become one of the most potential industries in the service industry. By analyzing the development environment and development trend of Chinese tourism industry from 2000 to 2016, we can understand the current situation of Chinese tourism development and provide suggestions for better development of Chinese tourism industry.

Forensic Science in Support of Wildlife Conservation Efforts - Genetic Approaches (Global Trends).

Science.gov (United States)

Linacre, A

2011-01-01

Wildlife forensic science is a relatively recent development to meet the increasing need of the criminal justice system where there are investigations in alleged transgressions of either international or national legislation. This application of science draws on conservation genetics and forensic geneticists from mainstream forensic science. This review is a broad overview of the history of forensic wildlife science and some of the recent developments in forensic wildlife genetics with the application of DNA developments to nonhuman samples encountered in a forensic science investigation. The review will move from methods to look at the entire genome, when there is no previous knowledge of the species studied, through methods of species identification, using DNA to determine a possible geographic origin, through to assigning samples to a particular individual or a close genetic relative of this individual. The transfer of research methods into the criminal justice system for the investigation of wildlife crimes has been largely successful as is illustrated in the review. The review concludes with comments on the need for standardization and regulation in wildlife forensic science. Copyright © 2011 Central Police University.

Trends in the development of radioisotope batteries

International Nuclear Information System (INIS)

Goeldner, R.; Leonhardt, J.W.; Radmaneche, R.; Schlegel, H.

1978-01-01

Improved methods for producing radioisotopes by nuclear fuel reprocessing and the rapid development of microelectronics offer new possibilities for utilizing radioisotope batteries. A review is given of the main principles of conversion of decay energy into electric power. The current state of such energy sources is evaluated. Finally, new fields of application and further trends in the development are indicated. (author)

Contemporary trends in the hotel industry development

Directory of Open Access Journals (Sweden)

Barjaktarović Dragan

2016-01-01

Full Text Available International tourism has a leading position in the world's economy at the end of the 20th century and at the beginning of the 21st century. The number of participants in international tourism is near one billion tourists. Tourism FX income is above USD 1.260 billion, globally. More than 2/3 of total tourism turn over is provided by hospitality and restaurants business, which is the best indicator of relevance of those industries, for further development of total economic development and the tourism. Projections of different relevant world's institutions go in direction that tourism will have dynamic developing trend which will provide its' stronger position in the world's industry development. In accordance with UNWTO's estimations, number of foreign tourists will increase up to 1.8 million and FX tourist income is expected to reach USD 2.000 billion at the end of 2030. In order to meet the sophisticated requests of the modern tourists and provide an answer to contemporary market trends, hotel industry, as the base part of tourism, will respond with the new qualitative, technology based facilities and services.

Genetics and plant development.

Science.gov (United States)

Prunet, Nathanaël; Meyerowitz, Elliot M

2016-01-01

There are only three grand theories in biology: the theory of the cell, the theory of the gene, and the theory of evolution. Two of these, the cell and gene theories, originated in the study of plants, with the third resulting in part from botanical considerations as well. Mendel's elucidation of the rules of inheritance was a result of his experiments on peas. The rediscovery of Mendel's work in 1900 was by the botanists de Vries, Correns, and Tschermak. It was only in subsequent years that animals were also shown to have segregation of genetic elements in the exact same manner as had been shown in plants. The story of developmental biology is different - while the development of plants has long been studied, the experimental and genetic approaches to developmental mechanism were developed via experiments on animals, and the importance of genes in development (e.g., Waddington, 1940) and their use for understanding developmental mechanisms came to botanical science much later - as late as the 1980s. Copyright © 2016 Académie des sciences. Published by Elsevier SAS. All rights reserved.

Trends in puberty timing in humans and environmental modifiers

DEFF Research Database (Denmark)

Toppari, Jorma; Juul, Anders

2010-01-01

Secular trends in timing of puberty appear to continue although under-nutrition has not been any longer a limiting factor for pubertal development. Now obesity and other environmental reasons have been suspected to cause this trend, and endocrine disrupting chemicals have become into focus...... as possible contributors. Epidemiological studies on endocrine disrupters are still scarce and show only weak associations between exposures and timing of puberty. Since genetic background explains 50-80% of variability in the timing of puberty, it is not surprising that the observed environmental effects...

Recent advances in genetic modification systems for Actinobacteria.

Science.gov (United States)

Deng, Yu; Zhang, Xi; Zhang, Xiaojuan

2017-03-01

Actinobacteria are extremely important to human health, agriculture, and forests. Because of the vast differences of the characteristics of Actinobacteria, a lot of genetic tools have been developed for efficiently manipulating the genetics. Although there are a lot of successful examples of engineering Actinobacteria, they are still more difficult to be genetically manipulated than other model microorganisms such as Saccharomyces cerevisiae, Escherichia coli, and Bacillus subtilis etc. due to the diverse genomics and biochemical machinery. Here, we review the methods to introduce heterologous DNA into Actinobacteria and the available genetic modification tools. The trends and problems existing in engineering Actinobacteria are also covered.

Genetic trends in maternal and neonatal behaviors and their association with perinatal survival in French Large White swine

Directory of Open Access Journals (Sweden)

Laurianne eCanario

2014-12-01

Full Text Available Genetic trends in maternal abilities were studied in French Large White sows. Two lines representing old-type and modern-type pigs were obtained by inseminating modern sows with semen from boars born in 1977 or 1998. Successive generations were produced by inter-se mating. The maternal performance of sows from the second generation was compared in farrowing crates. Video analysis was performed for the 1st h after the onset of 43 and 36 farrowing events, and for the 6 first hours for 23 and 21 events, in old-type and modern-type sows respectively. Genetic trends were estimated as twice the difference in estimates between the 2 lines. The contribution of behavior to the probability of stillbirth and piglet death in the first 2 days was estimated as the percentage of deviance reduction (DR due to the addition of behavior traits as factors in the mortality model. Sow activity decreased strongly from the 1st to the 2nd h in both lines (P < 0.001. In the first 6 h, old-type sows sat (1st parity, stood (2nd parity and rooted (both parities for longer than modern-type sows, which were less active, especially in 2nd parity. In modern-type sows, stillbirth was associated positively with lying laterally in the first 6 h (4.6% DR and negatively in the 1st h (9.1% DR. First-parity old-type sows were more attentive to piglets (P = 0.003 than modern-type sows which responded more to nose contacts at 2nd parity (P = 0.01. Maternal reactivity of modern-type sows was associated with a higher risk of piglet death (4.6% DR. Respiratory distress at birth tended to be higher in modern-type piglets than in old-type piglets (P < 0.10 and was associated with a higher risk of piglet death in both lines (2.7% to 3.1% DR. Mobility at birth was lower in modern-type than old-type piglets (P<0.0001. Genetic trends show that sow and piglet behaviors at farrowing have changed. Our results indicate reduced welfare in parturient modern-type sows and their newborn piglets.

SYSTEM ANALYSIS OF MAJOR TRENDS IN DEVELOPMENT OF ADAPTIVE TRAFFIC FLOW MANAGEMENT METHODS

Directory of Open Access Journals (Sweden)

A. N. Klimovich

2017-01-01

Full Text Available Adaptive algorithms, which current traffic systems are based on, exist for many decades. Information technologies have developed significantly over this period and it makes more relevant their application in the field of transport. This paper analyses modern trends in the development of adaptive traffic flow control methods. Reviewed the most perspective directions in the field of intelligent transport systems, such as high-speed wireless communication between vehicles and road infrastructure based on such technologies as DSRC and WAVE, traffic jams prediction having such features as traffic flow information, congestion, velocity of vehicles using machine learning, fuzzy logic rules and genetic algorithms, application of driver assistance systems to increase vehicle’s autonomy. Advantages of such technologies in safety, efficiency and usability of transport are shown. Described multi-agent approach, which uses V2I-communication between vehicles and intersection controller to improve efficiency of control due to more complete traffic flow information and possibility to give orders to separate vehicles. Presented number of algorithms which use such approach to create new generation of adaptive transport systems.

Public Awareness of Direct-to-Consumer Genetic Tests: Findings from the 2013 U.S. Health Information National Trends Survey.

Science.gov (United States)

Agurs-Collins, Tanya; Ferrer, Rebecca; Ottenbacher, Allison; Waters, Erika A; O'Connell, Mary E; Hamilton, Jada G

2015-12-01

Although the availability of direct-to-consumer (DTC) genetic testing has increased in recent years, the general public's awareness of this testing is not well understood. This study examined levels of public awareness of DTC genetic testing, sources of information about testing, and psychosocial factors associated with awareness of testing in the USA. Data were obtained from the nationally representative 2013 U.S. Health Information National Trends Survey. Guided by a social-cognitive conceptual framework, univariable and multivariable logistic regressions were conducted to identify factors associated with awareness of DTC genetic tests. Of 3185 participants, 35.6% were aware of DTC genetic tests, with the majority learning about these tests through radio, television, and the Internet. In the final adjusted model, participants with annual incomes of $99,999 or less had lower odds of being aware of DTC genetic testing (ORs ranging from 0.46-0.61) than did those participants with incomes of $100,000 or more. The odds of awareness of DTC genetic tests were significantly higher for those who actively seek cancer information (OR=1.91, 95% CI=1.36-2.69), use the Internet (OR=1.81, 95% CI=1.05-3.13), and have high numeracy skills (OR=1.67, 95% CI=1.17-2.38). It will be critical for healthcare researchers and practitioners to understand predictors and consequences of the public's awareness of DTC genetic tests, as well as how such awareness may translate into DTC genetic testing uptake, health behavior change, and ultimately disease prevention.

Engaging nurses in genetics: the strategic approach of the NHS National Genetics Education and Development Centre.

Science.gov (United States)

Kirk, Maggie; Tonkin, Emma; Burke, Sarah

2008-04-01

The UK government announced the establishment of an NHS National Genetics Education and Development Centre in its Genetics White Paper. The Centre aims to lead and coordinate developments to enhance genetics literacy of health professionals. The nursing program takes a strategic approach based on Ajzen's Theory of Planned Behavior, using the UK nursing genetics competences as the platform for development. The program team uses innovative approaches to raise awareness of the relevance of genetics, working collaboratively with policy stakeholders, as key agents of change in promoting competence. Providing practical help in preparing learning and teaching resources lends further encouragement. Evaluation of the program is dependent on gathering baseline data, and the program has been informed by an education needs analysis. The challenges faced are substantial and necessitate international collaboration where expertise and resources can be shared to produce a global system of influence to facilitate the engagement of non-genetic nurses.

TRENDS IN OFFICIAL DEVELOPMENT ASSISTANCE TO DEVELOPING COUNTRIES AND POSSIBILITIES OF ALTERNATIVE FINANCING MECHANISMS

Directory of Open Access Journals (Sweden)

Talknice Saungweme

2013-09-01

Full Text Available The study analyses trends in Official Development Assistance (ODA to developing countries, mainly Africa, and possibilities of new financing instruments. Economies of most developing countries, especially those in Sub-Saharan Africa, are characterised by low investment flows, huge import bills and lower exports. Subsequently, development assistance is the major source of external finance and has taken the form of budget support, humanitarian and development finance. However, the noted fall in ODA in 2005, 2009 and 2012 might adversely impact directly on the attainment of millennium development goals in 2015. This negative trend in ODA is a result of a combination of factors such as economic constraints in the donor countries (for example, the debt crisis and/or a new shift in financing mechanisms to developing countries.

Housing and Urban Development trends in Czech Republic

Directory of Open Access Journals (Sweden)

Karel Schmeidler

2008-01-01

Full Text Available This article describes housing trends in Czech Republic, which are determined by social, economic, technical and cultural changes of last two decades In Central Europe. Those trends have positive and also negative sides: positive can be seen the quantitative and qualitative growth of housing space, variety of architectural solutions for individualised customer. Negative aspect is urban sprawl, which together with individual automobile occupancy destroys nature, space and land values. Future development is inevitable, proper design of housing needs sensitive multidisciplinal attitude and understanding of the needs of man and nature.

Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development.

Directory of Open Access Journals (Sweden)

Nuno D Pires

2016-01-01

Full Text Available Embryonic development requires a correct balancing of maternal and paternal genetic information. This balance is mediated by genomic imprinting, an epigenetic mechanism that leads to parent-of-origin-dependent gene expression. The parental conflict (or kinship theory proposes that imprinting can evolve due to a conflict between maternal and paternal alleles over resource allocation during seed development. One assumption of this theory is that paternal alleles can regulate seed growth; however, paternal effects on seed size are often very low or non-existent. We demonstrate that there is a pool of cryptic genetic variation in the paternal control of Arabidopsis thaliana seed development. Such cryptic variation can be exposed in seeds that maternally inherit a medea mutation, suggesting that MEA acts as a maternal buffer of paternal effects. Genetic mapping using recombinant inbred lines, and a novel method for the mapping of parent-of-origin effects using whole-genome sequencing of segregant bulks, indicate that there are at least six loci with small, paternal effects on seed development. Together, our analyses reveal the existence of a pool of hidden genetic variation on the paternal control of seed development that is likely shaped by parental conflict.

Organizational Development of Russian SMEs: Current trends

Directory of Open Access Journals (Sweden)

Emil Velinov

2016-12-01

Full Text Available The research paper sheds a light on Russian SMEs transition and specifically on their current development and evolution. The paper attempts to explain what are the main drivers and antecedents on SMEs during the period 2010-2015. Along with it, it is applied detailed analysis of Russian SMEs in terms of key performance indicators, turnover and volume of sales. Further, are given potential developments and trends within SMEs in Russia. The paper draws attention to socio-economic and political factors influencing SMEs development.

Artificial Neural Network and Genetic Algorithm Hybrid Intelligence for Predicting Thai Stock Price Index Trend

Science.gov (United States)

Boonjing, Veera; Intakosum, Sarun

2016-01-01

This study investigated the use of Artificial Neural Network (ANN) and Genetic Algorithm (GA) for prediction of Thailand's SET50 index trend. ANN is a widely accepted machine learning method that uses past data to predict future trend, while GA is an algorithm that can find better subsets of input variables for importing into ANN, hence enabling more accurate prediction by its efficient feature selection. The imported data were chosen technical indicators highly regarded by stock analysts, each represented by 4 input variables that were based on past time spans of 4 different lengths: 3-, 5-, 10-, and 15-day spans before the day of prediction. This import undertaking generated a big set of diverse input variables with an exponentially higher number of possible subsets that GA culled down to a manageable number of more effective ones. SET50 index data of the past 6 years, from 2009 to 2014, were used to evaluate this hybrid intelligence prediction accuracy, and the hybrid's prediction results were found to be more accurate than those made by a method using only one input variable for one fixed length of past time span. PMID:27974883

Artificial Neural Network and Genetic Algorithm Hybrid Intelligence for Predicting Thai Stock Price Index Trend

Directory of Open Access Journals (Sweden)

Montri Inthachot

2016-01-01

Full Text Available This study investigated the use of Artificial Neural Network (ANN and Genetic Algorithm (GA for prediction of Thailand’s SET50 index trend. ANN is a widely accepted machine learning method that uses past data to predict future trend, while GA is an algorithm that can find better subsets of input variables for importing into ANN, hence enabling more accurate prediction by its efficient feature selection. The imported data were chosen technical indicators highly regarded by stock analysts, each represented by 4 input variables that were based on past time spans of 4 different lengths: 3-, 5-, 10-, and 15-day spans before the day of prediction. This import undertaking generated a big set of diverse input variables with an exponentially higher number of possible subsets that GA culled down to a manageable number of more effective ones. SET50 index data of the past 6 years, from 2009 to 2014, were used to evaluate this hybrid intelligence prediction accuracy, and the hybrid’s prediction results were found to be more accurate than those made by a method using only one input variable for one fixed length of past time span.

Trends in Nuclear Explosion Monitoring Research & Development - A Physics Perspective

Energy Technology Data Exchange (ETDEWEB)

Maceira, Monica [Los Alamos National Laboratory; Blom, Philip Stephen [Los Alamos National Laboratory; Maccarthy, Jonathan K. [Los Alamos National Laboratory; Marcillo, Omar Eduardo [Los Alamos National Laboratory; Euler, Garrett Gene [Los Alamos National Laboratory; Begnaud, Michael Lee [Los Alamos National Laboratory; Ford, Sean R. [Lawrence Livermore National Laboratory; Pasyanos, Michael E. [Lawrence Livermore National Laboratory; Orris, Gregory J. [Naval Research Laboratory; Foxe, Michael P. [Pacific Northwest National Laboratory; Arrowsmith, Stephen J. [Sandia National Laboratory; Merchant, B. John [Sandia National Laboratory; Slinkard, Megan E. [Sandia National Laboratory

2017-06-01

This document entitled “Trends in Nuclear Explosion Monitoring Research and Development – A Physics Perspective” reviews the accessible literature, as it relates to nuclear explosion monitoring and the Comprehensive Nuclear-Test-Ban Treaty (CTBT, 1996), for four research areas: source physics (understanding signal generation), signal propagation (accounting for changes through physical media), sensors (recording the signals), and signal analysis (processing the signal). Over 40 trends are addressed, such as moving from 1D to 3D earth models, from pick-based seismic event processing to full waveform processing, and from separate treatment of mechanical waves in different media to combined analyses. Highlighted in the document for each trend are the value and benefit to the monitoring mission, key papers that advanced the science, and promising research and development for the future.

Global Status of Genetically Modified Crops: Current Trends and Prospects

OpenAIRE

Hautea, Randy A.

2002-01-01

Modern biotechnology-facilitated crop improvement is undoubtedly one of the most significant technological developments in agriculture. The first wave of genetically-modified (GM) or transgenic crops include cultivars with important input traits such as herbicide tolerance and insect resistance. Future products are expected to provide benefits that could include tolerance to environmental stresses and enhanced nutritional content, which can be particularly valuable in crops that are important...

Trend of Energy Saving in Electronic Devices for Research and Development

Directory of Open Access Journals (Sweden)

Rahmayanti R.

2016-01-01

Full Text Available In electronic industry, energy saving is one of the performance indicators of competitiveness beside price, speed, bandwidth and reliability. This affects research and development (R&D activity in mechatronic systems which uses electronic components and electronic systems. A review of trend of electronic devices technology development has been conducted with focus on energy saving. This review includes electronic devices, semiconductor, and nanotechnology. It can be concluded that the trend in electronic devices is mainly dictated by semiconductor technology development. The trend can be concluded as smaller size, lower voltage leading to energy saving, less heat, higher speed, more reliable, and cheaper. In accordance to such technology development, R&D activities in mechatronics especially in Indonesia is being pushed to make proper alignment.Some of such alignment actions are surface mount technology (SMT for installing surface mount devices components (SMD, design layout and SMD troubleshooting tools as well as human resources training and development.

25 years acidification monitoring in Bavaria. Trends and developments; 25 Jahre Versauerungsmonitoring in Bayern. Trends und Entwicklungen

Energy Technology Data Exchange (ETDEWEB)

Scheel, Thorsten

2015-07-15

In Bavaria, the development of the atmospheric caused acidification within all relevant environmental compartments (soil, water, air) is monitored by an intensive monitoring for more than 25 years. This report covers the trends and developments of chemical and biological indicators of flowing waters, groundwater and lakes are summarized evaluated and displayed. [German] In Bayern wird seit mehr als 25 Jahren die Entwicklung der atmosphaerisch bedingten Versauerung innerhalb aller betroffenen Umweltkompartimente (Boden, Wasser, Luft) durch ein intensives Monitoring ueberwacht. In diesem Bericht sind die Trends und Entwicklungen chemischer und biologischer Indikatoren der Fliessgewaesser, Grundwaesser und Seen zusammenfassend ausgewertet und dargestellt.

Social BI. Trends and development needs

Directory of Open Access Journals (Sweden)

Corneliu Mihai PREDA

2014-12-01

Full Text Available This paper tries to show that the need to implement BI solutions that integrate social networks data is increasingly more acute. Companies need to understand that efficient decision making has to take into account the importance that social medial has nowadays. In addition, the software developing companies have to keep up to date with new trends generated within these communication channels and adapt their solutions to this dynamic environment.

Latest trends and directions of development of crowdfunding

Directory of Open Access Journals (Sweden)

Joanna Pieniążek

2014-09-01

Full Text Available The article discusses the latest trends and directions of development of crowdfunding on selected examples of English-language websites.The scope of work includes topics such as aggregates of crowdfunding sites, local investing, franchise, pre-sales platforms, open source sites and leveraging the competitive advantages of e-commerce platforms which offer product crowdfunding. This article aims to discuss the latest trends and directions of crowdfunding, assess their usefulness and the chances of popularising the ideas presented. The article provides an overview of the literature on the subject and an analysis of the selected sites, comparison sites and crowdfunding search engines.

Development trends of the venture capital financing institution: spaciotemporal profile

Directory of Open Access Journals (Sweden)

T. I. Volkova

2010-09-01

Full Text Available The article describes the results of the research of development and performance features of the venture capital financing institution in leading countries as well as in Russia and in its regions. A number of main trends in venture financing in accordance with the level of innovation process` development abroad and in our country are emphasized, first of all by stages of support of scientific and technological developments and projects. Positive trends and contradictions in development of venture capital financing institution in Russia and its regions are revealed. Main directions of activation of venture financing process are systematized in accordance with the requirements of the Concept of long-term social-economic development of the Russian Federation till 2020 and the Strategy of social-economic development of the Sverdlovsk region until 2020.

Demand for luxury cars in China: development, trends and prospects

OpenAIRE

Heinonen, Tommi

2014-01-01

Purpose of this thesis was to investigate what is demand for luxury cars in People's Republic of China and how it has developed, what trends there are and what direction development is going currently. The topic of this thesis was selected based on how interesting it is and how current the topic is at the moment. Objective was to find out what is the demand of luxury cars in China, what kind of buyers Chinese consumers are in field of luxury cars, what trends there are and what are the charac...

Career Development Trends and Issues in the United States.

Science.gov (United States)

Hansen, L. Sunny

1993-01-01

Discusses global economic, political, and social trends affecting the workplace, families, education, and gender roles. Depicts current career development programs and practices with children and young, midlife, and older adults. Presents current issues in schools, adult education, and business/industry for career development. (SK)

Developing genetic privacy legislation: the South Carolina experience.

Science.gov (United States)

Edwards, J G; Young, S R; Brooks, K A; Aiken, J H; Patterson, E D; Pritchett, S T

1998-01-01

The availability of presymptomatic and predisposition genetic testing has spawned the need for legislation prohibiting health insurance discrimination on the basis of genetic information. The federal effort, the Health Insurance Portability and Accountability Act (HIPAA) of 1996, falls short by protecting only those who access insurance through group plans. A committee of University of South Carolina professionals convened in 1996 to develop legislation in support of genetic privacy for the state of South Carolina. The legislation prevents health insurance companies from denying coverage or setting insurance rates on the basis of genetic information. It also protects the privacy of genetic information and prohibits performance of genetic tests without specific informed consent. In preparing the bill, genetic privacy laws from other states were reviewed, and a modified version of the Virginia law adopted. The South Carolina Committee for the Protection of Genetic Privacy version went a step further by including enforcement language and excluding Virginia's sunset clause. The definition of genetic information encompassed genetic test results, and importantly, includes family history of genetic disease. Our experience in navigating through the state legislature and working through opposition from the health insurance lobby is detailed herein.

Role of genetics in the development of pediatric nephrology

Directory of Open Access Journals (Sweden)

M. S. Ignatova

2015-01-01

Full Text Available Generalized data on the role of medical genetics in the development of pediatric nephrology are given on the basis of the authors’ observations and modern literature. It is shown that the introduction of genetic researches into the practice of a pediatric nephrologist can change the view of the etiology of many diseases, decipher the essence of a number of nephropathies, the cause of which was unclear, and reduce the number of idiopathic diseases. This is particularly important for the determination of therapeutic tactics and the emergence of new pathogenic agents that can improve prognosis and quality of life in patients in a number of genetic diseases. Particular attention is drawn to hereditary nephropathy accompanied by hematuria and particularly to Alport syndrome characterized by a progressive course. The development of genetics and clinical introduction of its advances have recently led to the identification of a new nosological entity — hereditary C3 glomerulonephritis as a result of CFHR5 gene mutation. Thanks to the development of genetic technologies, new genetic kidney diseases are certain to be disclosed in the next future. 

Modern trends in the development of road equipment

OpenAIRE

Nіchke, V.; Demіshkan, V.; Yermakova, O.

2007-01-01

Factors, which affect prospects for road equipment or determine trends in their development, have been considered. On the base of their analysis determine what technique to make or buy. Decisions as to purchasing or manufacturing are made on the basis of this analysis.

Modeling lodgepole pine radial growth relative to climate and genetics using universal growth-trend response functions.

Science.gov (United States)

McLane, Sierra C; LeMay, Valerie M; Aitken, Sally N

2011-04-01

Forests strongly affect Earth's carbon cycles, making our ability to forecast forest-productivity changes associated with rising temperatures and changes in precipitation increasingly critical. In this study, we model the influence of climate on annual radial growth using lodgepole pine (Pinus contorta) trees grown for 34 years in a large provenance experiment in western Canada. We use a random-coefficient modeling approach to build universal growth-trend response functions that simultaneously incorporate the impacts of different provenance and site climates on radial growth trends under present and future annual (growth-year), summer, and winter climate regimes. This approach provides new depth to traditional quantitative genetics population response functions by illustrating potential changes in population dominance over time, as well as indicating the age and size at which annual growth begins declining for any population growing in any location under any present or future climate scenario within reason, given the ages and climatic conditions sampled. Our models indicate that lodgepole pine radial-growth levels maximize between 3.9 degrees and 5.1 degrees C mean growth-year temperature. This translates to productivity declining by the mid-21st century in southern and central British Columbia (BC), while increasing beyond the 2080s in northern BC and Yukon, as temperatures rise. Relative to summer climate indices, productivity is predicted to decline continuously through the 2080s in all locations, while relative to winter climate variables, the opposite trend occurs, with the growth increases caused by warmer winters potentially offsetting the summer losses. Trees from warmer provenances, i.e., from the center of the species range, perform best in nearly all of our present and future climate-scenario models. We recommend that similar models be used to analyze population growth trends relative to annual and intra-annual climate in other large-scale provenance

Genetic and nutrition development of indigenous chicken in Africa

DEFF Research Database (Denmark)

Khobondo, J O; Muasya, T K; Miyumo, S

2015-01-01

This review gives insights into genetic and feeding regime development for indigenous chicken genetic resources. We highlight and combine confirming evidence of genetic diversity and variability using morphological and molecular techniques. We further discuss previous past and current genetic...... requirement for indigenous chicken and report nutritive contents of various local feedstuffs under various production systems. Various conservation strategies for sustainable utilization are hereby reviewed...

Primer Part 1-The building blocks of epilepsy genetics.

Science.gov (United States)

Helbig, Ingo; Heinzen, Erin L; Mefford, Heather C

2016-06-01

This is the first of a two-part primer on the genetics of the epilepsies within the Genetic Literacy Series of the Genetics Commission of the International League Against Epilepsy. In Part 1, we cover the foundations of epilepsy genetics including genetic epidemiology and the range of genetic variants that can affect the risk for developing epilepsy. We discuss various epidemiologic study designs that have been applied to the genetics of the epilepsies including population studies, which provide compelling evidence for a strong genetic contribution in many epilepsies. We discuss genetic risk factors varying in size, frequency, inheritance pattern, effect size, and phenotypic specificity, and provide examples of how genetic risk factors within the various categories increase the risk for epilepsy. We end by highlighting trends in epilepsy genetics including the increasing use of massive parallel sequencing technologies. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

Trends in the development of polycondensation and condensation polymers

International Nuclear Information System (INIS)

Vinogradova, Svetlana V; Vasnev, Valery A

2004-01-01

New trends in the development of polycondensation methods, elucidation of the main principles of macromolecular design of polymeric chains and preparation of novel promising condensation polymers are considered and analysed.

Medical Genetics at McGill: The History of a Pioneering Research Group.

Science.gov (United States)

Canning, Christopher; Weisz, George; Tone, Andrea; Cambrosio, Alberto

2013-01-01

The McGill Group in Medical Genetics was formed in 1972, supported by the Medical Research Council and successor Canadian Institutes for Health Research until September 2009, making it the longest active biomedical research group in the history of Canada. We document the history of the McGill Group and situate its research within a broader history of medical genetics. Drawing on original oral histories with the Group's members, surviving documents, and archival materials, we explore how the Group's development was structured around epistemological trends in medical genetics, policy choices made by research agencies, and the development of genetics at McGill University and its hospitals.

Estimates of genetic parameters, genetic trends, and inbreeding in a crossbred dairy sheep research flock in the United States.

Science.gov (United States)

Murphy, T W; Berger, Y M; Holman, P W; Baldin, M; Burgett, R L; Thomas, D L

2017-10-01

the addition of breed effects, on ewe year of birth revealed a positive genetic gain of 2.30 and 6.24 kg/yr, respectively, over the past 20 yr in this flock. Inbreeding coefficients of ewes with an extended pedigree ranged from 0.0 to 0.29, with an average of 0.07. To optimize genetic gains and avoid excessive inbreeding, the development of a national genetic improvement program should be a top priority for the growing dairy sheep industry.

Research and development studies on human factors: new trends

International Nuclear Information System (INIS)

Llory, M.; Larchier-Boulanger, J.

1988-01-01

This paper is aimed at describing where the research work on human factors undertaken at EDF stands in relation to this European trend and to define the problematics of cognitive phenomena in relation to all (non cognitive) human phenomena, on the one hand, and to individual aspects as compared to collective and organizational aspects, on the other. Some important trends in the research and development studies will thus be examined one lay one: - analysis of operators' activity; - analysis of the activity cognitive aspects; - problem of the impact of non-cognitive aspects

Oil development in China: Current status and future trends

International Nuclear Information System (INIS)

Ma Linwei; Fu Feng; Li Zheng; Liu Pei

2012-01-01

The future of oil has become an important topic of the discussion of energy policy in China. This paper attempts to present a full picture of the current status and future trends of China’s oil development through system analysis. First, we map a Sankey diagram of China’s oil flow to reveal the physical pattern of China’s oil supply and consumption. Then, we present the historical and ongoing trends of China’s oil flow from key aspects such as oil demand, oil resource availability, technology improvement, and policy adjustment. Based on these understandings, we design three scenarios of China’s oil demand in 2030, and analyze policy implications for oil saving, automotive energy development, and energy security. From the analysis, we draw some conclusions for policy decisions, such as to control the total oil consumption to avoid energy security risks, to enhance oil saving in all sectors with road transportation as the emphasis, and to increase the investment on oil production and refining to secure oil supply and reduce emissions. - Highlights: ► A Sankey Diagram to reveal the physical pattern of China’s oil supply and consumption. ► Present the ongoing trends of China’s oil development. ► Discuss important policy issues such as oil saving, energy security, and emissions reduction.

Recent trends and patterns of Nigeria's industrial development ...

African Journals Online (AJOL)

This paper analyzes recent trend and the spatial patterns of manufacturing in Nigeria. In particular, the paper shows that industrial development in the country involved considerable craft works firms in the early stages and grew progressively in number over the years to large-scale manufacturing. The contribution of ...

Prestudy - Development of trend analysis of component failure

International Nuclear Information System (INIS)

Poern, K.

1995-04-01

The Bayesian trend analysis model that has been used for the computation of initiating event intensities (I-book) is based on the number of events that have occurred during consecutive time intervals. The model itself is a Poisson process with time-dependent intensity. For the analysis of aging it is often more relevant to use times between failures for a given component as input, where by 'time' is meant a quantity that best characterizes the age of the component (calendar time, operating time, number of activations etc). Therefore, it has been considered necessary to extend the model and the computer code to allow trend analysis of times between events, and also of several sequences of times between events. This report describes this model extension as well as an application on an introductory ageing analysis of centrifugal pumps defined in Table 5 of the T-book. The application in turn directs the attention to the need for further development of both the trend model and the data base. Figs

Multi-target drugs: the trend of drug research and development.

Science.gov (United States)

Lu, Jin-Jian; Pan, Wei; Hu, Yuan-Jia; Wang, Yi-Tao

2012-01-01

Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.

Nuclear energy - overview of development trends

International Nuclear Information System (INIS)

1985-01-01

Proceeding from the organizational structure of the IAEA selected activities of the IAEA in connection with power reactor safety are dealt with. Based on the IAEA's computerized Power Reactor Information System (PRIS) a survey is presented of the most recent statistical data concerning status and trends of nuclear power plant development throughout the world. The central role of the IAEA in assisting Member States in the utilization of nuclear energy for peaceful purposes is underscored. Finally, a brief account of the state-of-the-art of the USSR's nuclear power programme is given

Genetic testing in the workplace: the employer's coin toss.

Science.gov (United States)

French, Samantha

2002-09-05

A toss of the coin by the modern-day employer reveals two options regarding genetic testing in the workplace. The employer may choose to take advantage of increasingly precise, available, and affordable genetic testing in order to ascertain the genetic characteristics--and deficiencies--of its employees. This outcome exposes the employer to a vast array of potential litigation and liability relating to the Americans with Disabilities Act, the Fourth Amendment, Title VII of the Civil Rights Act, and state legislation designed to protect genetic privacy. Alternatively, the employer may neglect to indulge in this trend of genetic testing and may face liability for employer negligence, violations of federal legislation such as OSHA regulations, and increased costs associated with insuring the health of genetically endangered employees. In the rapidly developing universe of genetic intelligence, the employer is faced with a staggering dilemma.

Trends in puberty timing in humans and environmental modifiers

DEFF Research Database (Denmark)

Toppari, Jorma; Juul, Anders

2010-01-01

Secular trends in timing of puberty appear to continue although under-nutrition has not been any longer a limiting factor for pubertal development. Now obesity and other environmental reasons have been suspected to cause this trend, and endocrine disrupting chemicals have become into focus...... as possible contributors. Epidemiological studies on endocrine disrupters are still scarce and show only weak associations between exposures and timing of puberty. Since genetic background explains 50-80% of variability in the timing of puberty, it is not surprising that the observed environmental effects...... are rather modest when individual exposures are assessed. Despite that, some exposures have been reported to be associated to early (e.g., polybrominated biphenyls) or delayed (e.g., lead) puberty. Here we shortly review the available data on recent trends in timing of puberty and the possible role...

Genetic approaches to understanding the population-level impact of wind energy development on migratory bats

Energy Technology Data Exchange (ETDEWEB)

Vonhof, Maarten J. [Western Michigan Univ., Kalamazoo MI (United States); Russell, Amy L. [Grand Valley State Univ. Allendale, MI (United States)

2013-09-30

Documented fatalities of bats at wind turbines have raised serious concerns about the future impacts of increased wind power development on populations of migratory bat species. Yet there is little data on bat population sizes and trends to provide context for understanding the consequences of mortality due to wind power development. Using a large dataset of both nuclear and mitochondrial DNA variation for eastern red bats, we demonstrated that: 1) this species forms a single, panmictic population across their range with no evidence for the historical use of divergent migratory pathways by any portion of the population; 2) the effective size of this population is in the hundreds of thousands to millions; and 3) for large populations, genetic diversity measures and at least one coalescent method are insensitive to even very high rates of population decline over long time scales and until population size has become very small. Our data provide important context for understanding the population-level impacts of wind power development on affected bat species.

INTEGRATED HSEQ MANAGEMENT SYSTEMS: DEVELOPMENTS AND TRENDS

Directory of Open Access Journals (Sweden)

Osmo Kauppila

2015-06-01

Full Text Available The integration of health and safety, environmental and quality (HSEQ management systems has become a current topic in the 21st century, as the need for systems thinking has grown along with the number of management system standards. This study aims to map current developments and trends in integrated HSEQ management. Three viewpoints are taken: the current state of the main HSEQ management standards, research literature on integrated management systems (IMS, and a case study of an industry-led HSEQ cluster in Northern Finland. The results demonstrate that some of the most prominent current trends are the harmonization of the high level structure of management systems by ISO, the evaluation of IMS, accounting for the supply chain in HSEQ issues, and sustainability and risk management. The results of the study can be used by practitioners to get a view of the current state of HSEQ management systems and their integration, and by researchers to seek out potential directions for HSEQ and IMS related research.

Genetic disorders of thyroid metabolism and brain development

Science.gov (United States)

Kurian, Manju A; Jungbluth, Heinz

2014-01-01

Normal thyroid metabolism is essential for human development, including the formation and functioning of the central and peripheral nervous system. Disorders of thyroid metabolism are increasingly recognized within the spectrum of paediatric neurological disorders. Both hypothyroid and hyperthyroid disease states (resulting from genetic and acquired aetiologies) can lead to characteristic neurological syndromes, with cognitive delay, extrapyramidal movement disorders, neuropsychiatric symptoms, and neuromuscular manifestations. In this review, the neurological manifestations of genetic disorders of thyroid metabolism are outlined, with particular focus on Allan-Herndon-Dudley syndrome and benign hereditary chorea. We report in detail the clinical features, major neurological and neuropsychiatric manifestations, molecular genetic findings, disease mechanisms, and therapeutic strategies for these emerging genetic ‘brain-thyroid’ disorders. PMID:24665922

Current trends in plant breeding

International Nuclear Information System (INIS)

Jalani, B.S.; Rajanaidu, N.

2000-01-01

The current world population is 6 billion and it is likely to reach 7 billion in 2010 and 8 billion 2025. Sufficient food must be produced for the ever increasing human population. The available suitable land for intensive agriculture is limited. We have to produce more food from less land, pesticide, labour and water resources. Hence, increase in crop productivity are essential to feed the world in the next century. Plant breeding provides the avenue to increase the food production to feed the growing world population. Development of a cultivar involves (I) Construction of a genetic model (II) creating a gene pool (III) selection among plants and (IV) testing the selected genotypes for adaptation to the biotic and abiotic environments (Frey, 1999). This paper discusses the trends in plant breeding using the oil palm as a model. It covers (i) genetic resources (ii) physiological traits (III) exploitation of genotype x environment interaction (IV) oil palm clones, and (v) biotechnology application. (Author)

Child Development and Molecular Genetics: 14 Years Later

Science.gov (United States)

Plomin, Robert

2013-01-01

Fourteen years ago, the first article on molecular genetics was published in this journal: "Child Development, Molecular Genetics, and What to Do With Genes Once They Are Found" (R. Plomin & M. Rutter, 1998). The goal of the article was to outline what developmentalists can do with genes once they are found. These new directions for developmental…

INTEGRATED HSEQ MANAGEMENT SYSTEMS: DEVELOPMENTS AND TRENDS

OpenAIRE

Osmo Kauppila; Janne Härkönen; Seppo Väyrynen

2015-01-01

The integration of health and safety, environmental and quality (HSEQ) management systems has become a current topic in the 21st century, as the need for systems thinking has grown along with the number of management system standards. This study aims to map current developments and trends in integrated HSEQ management. Three viewpoints are taken: the current state of the main HSEQ management standards, research literature on integrated management systems (IMS), and a case study of an industry...

Developing a meaningful QA trend analysis program

International Nuclear Information System (INIS)

Sternberg, A.

1987-01-01

A trend analysis program is being developed by the nuclear quality assurance (NQA) department at Public Service Electric and Gas Company, adapted from the principles advocated by W. Edwards Deming using statistical process control methods. It deals with identifying performance indicators that monitor the activities of a process considering both inputs and outputs, determining whether the process is stable or unstable, taking actions accordingly, and continuing to monitor the process with the objective of continual improvement of quality

Emerging Genetic Counselor Roles within the Biotechnology and Pharmaceutical Industries: as Industry Interest Grows in Rare Genetic Disorders, How are Genetic Counselors Joining the Discussion?

Science.gov (United States)

Field, Tessa; Brewster, Stephanie Jo; Towne, Meghan; Campion, MaryAnn W

2016-08-01

Traditionally, the biotechnology and pharmaceutical industry (BPI) has focused drug development at the mass-market level targeting common medical issues. However, a recent trend is the development of therapies for orphan or rare disorders, including many genetic disorders. Developing treatments for genetic disorders requires an understanding of the needs of the community and translating genomic information to clinical and non-clinical audiences. The core skills of genetic counselors (GCs) include a deep knowledge of genetics and ability to communicate complex information to a broad audience, making GCs a choice fit for this shift in drug development. To date there is limited data defining the roles GCs hold within this industry. This exploratory study aimed to define the roles and motivation of GCs working in BPI, assess job satisfaction, and identify translatable skills and current gaps in GC training programs. The authors surveyed 26 GCs working in BPI in the United States; 79 % work for companies focused on rare disorders. GC positions in BPI are growing, with 57 % of respondents being the first GC in their role. GCs in BPI continue to utilize core genetic counseling competencies, though 72 % felt their training did not fully prepare them for BPI. These data suggest opportunities for exposure to BPI in GC training to better prepare future generations of GCs for these career opportunities. GC satisfaction was high in BPI, notably in areas traditionally reported as less satisfying on the National Society for Genetic Counselors Professional Status Survey: salary and advancement opportunities. BPI's growing interest in rare disorders represents a career opportunity for GCs, addressing both historic areas of dissatisfaction for GCs and BPI's genomic communication needs.

Trends in the development of reactor containments

International Nuclear Information System (INIS)

Turricchia, A.

1977-01-01

The paper presents a review of the technical developments which the containment systems of BWRs, PWRs and HWRs have undergone in the USA, Europe and Canada. The great variety of existing containment systems have been classified for each type of reactor, according to: principle of operation (i.e. dry containment; pressure suppression containment; containment with vacuum building; sub-atmospheric containment; etc.); type and number of the physical barriers provided against the dispersion of fission products to the environment (single containment, double containment, single containment with local collection of the leaks from the most probable leakage paths, or with pressurization of the potential leakage paths, etc.); and structural characteristics of the containment barriers (reinforced concrete, prestressed concrete, metal containment, liners). In the framework of this classification the main features of the various containment systems are illustrated, with special emphasis on the most modern designs. The difference in trend among various countries and various designers are highlighted. A review is also made of the various containment auxiliary systems which would operate in accident conditions (isolation systems, heat removal system, atmosphere control system, etc.). Also for these systems the main design criteria are set forth and present trends are described. Finally, a brief survey is also made of the present trends with regards to the design of containment structures against external events be they of natural origin (earthquake, tornadoes, etc.) or connected with human activities (airplane crash, explosions, etc.) [fr

Trends and developments in community and applied social psychology: JCASP 1991-2010

NARCIS (Netherlands)

Schruijer, S.G.L.; Stephenson, G.S.

2010-01-01

This paper looks back on the trends and developments in and of the Journal of Community and Applied Social Psychology since its inception twenty years ago. We review to what extent the aims that were originally set for JCASP have been fulfilled. The trends in nationality of authors, themes of

TRENDS OF ROMANIAN BANKING NETWORK DEVELOPMENT

Directory of Open Access Journals (Sweden)

Nicoleta Georgeta PANAIT

2015-07-01

Full Text Available Since 2009, two trends occurred in the banking world: downsizing of personnel, on the one hand and the reduction of retail units held, on the other hand. The first trend was most notable in countries with unstable or weak economy. The effects were seen immediately. Reducing of the operating costs and more applied of the territorial structure and staff was a decision that credit institutions in Romania took relatively late. Worldwide banks began a restructuring otherwise dictated by this time not so economic crises new market trends - increasing access to the internet for the population and use of the internet in a growing proportion of internet banking

Genetic parameters and genetic trends in the Chinese × European Tiameslan composite pig line. I. Genetic parameters

Directory of Open Access Journals (Sweden)

Legault Christian

2000-01-01

Full Text Available Abstract Genetic parameters of body weight at 4 (W4 w, 8 (W8 w and 22 (W22 w weeks of age, days from 20 to 100 kg (DT, average backfat thickness at 100 kg (ABT, teat number (TEAT, number of good teats (GTEAT, total number of piglets born (TNB, born alive (NBA and weaned (NW per litter, and birth to weaning survival rate (SURV were estimated in the Chinese × European Tiameslan composite line using restricted maximum likelihood methodology applied to a multiple trait animal model. Performance data from a total of 4 881 males and 4 799 females from 1 341 litters were analysed. Different models were fitted to the data in order to estimate the importance of maternal effects on production traits, as well as genetic correlations between male and female performance. The results showed the existence of significant maternal effects on W4w, W8w and ABT and of variance heterogeneity between sexes for W22w, DT, ABT and GTEAT. Genetic correlations between sexes were 0.79, 0.71 and 0.82, respectively, for W22w, DT and ABT and above 0.90 for the other traits. Heritability estimates were larger than (ABT and TEAT or similar to (other traits average literature values. Some genetic antagonism was evidenced between production traits, particularly W4w, W8w and ABT, and reproductive traits.

Genetic and environmental trends of early growth traits in the ...

African Journals Online (AJOL)

Data from the Elsenburg Dormer sheep stud were used to estimate genetic and environmental change in early growth traits from 1943 to 1990. .... The Elsenburg stud is not only the foundation Dormer stud, ... derivative-free algorithm. Genet.

Trend curve data development and testing

International Nuclear Information System (INIS)

McElroy, W.N.; Gold, R.; Simons, R.L.; Roberts, J.H.

1986-01-01

Existing trend curves do not account for previous and more recently observed test and power reactor flux-level, thermal neutron and γ-ray field-induced effects. Any agreement between measured data and trend curve predictions that does not adequately represent the important neutron environmental and temperature effects as well as the microstructural damage processes, therefore, could be fortuitous. Empirically derived end-of-life (EOL) and life-extension-range (LER) trend curves are presented and discussed in this paper for high temperature [∼288 0 C (550 0 F)] irradiation of two weld, two plate, and two forging pressure vessel (PV) steels and low-temperature [∼60 0 C (140 0 F)] irradiation of one support structure-type steel

Trends and developments in magnetic confinement fusion reactor concepts

International Nuclear Information System (INIS)

Baker, C.C.; Carlson, G.A.; Krakowski, R.A.

1981-01-01

An overview is presented of recent design trends and developments in reactor concepts for magnetic confinement fusion. The paper emphasizes the engineering and technology considerations of commercial fusion reactor concepts. Emphasis is placed on reactors that operate on the deuterium/tritium/lithium fuel cycle. Recent developments in tokamak, mirror, and Elmo Bumpy Torus reactor concepts are described, as well as a survey of recent developments on a wide variety of alternate magnetic fusion reactor concepts. The paper emphasizes recent developments of these concepts within the last two to three years

Electronic commerce in China:current status, development strategies, and new trends

Institute of Scientific and Technical Information of China (English)

Xiang Junyong; Jing Linbo

2014-01-01

After years of development in China's electronic commerce sector,there has been a drastic increase not only in the number of electronic commerce enterprises and online shoppers,but also in electronic commerce market turnover in China.During this process,the Chinese government has played a key role in establishing legislation and market disciplines for the electronic commerce market.This paper explores policy regarding electronic commerce development in China and analyzes new trends in China's electronic commerce,including the rise of mobile commerce,social commerce,and cross-border electronic commerce,and the booming industries of internet financing and Big Data.This paper aims to provide a better understanding of the development,uniqueness,and trends of electronic commerce in China.In addition,this paper also provides policymakers in China and other developing countries with policy suggestions regarding electronic commerce.

Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices.

Science.gov (United States)

Wolyniak, Michael J; Bemis, Lynne T; Prunuske, Amy J

2015-01-01

Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student's critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics.

Improving medical students’ knowledge of genetic disease: a review of current and emerging pedagogical practices

Science.gov (United States)

Wolyniak, Michael J; Bemis, Lynne T; Prunuske, Amy J

2015-01-01

Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student’s critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics. PMID:26604852

Genetic predictors of obesity development

Directory of Open Access Journals (Sweden)

Svetlana V. Borodina

2016-05-01

Full Text Available The most common reasons that cause obesity are eating disorders (overeating, genetic predisposition, sedentary lifestyle (lack of exercise, disorders of the endocrine system, and environmental factors. There is evidence of an obvious relationship of high consumption of sugary drinks and weight gain. Since 1990, there has been considerable growth in the number of obese people in the first place associated with the promotion of soft drinks. According to a study in Finnish diabetes prevention average physical activity and change of diet (1200-1800 kcal of total fat intake with less than 30% saturated fat, including less than 10%, leading to long-term loss of excess weight (within 4 years. Many studies have demonstrated the impossibility of a single template approach to the determination of optimal diets for patients with overweight and obesity which has been shown in various studies on gene polymorphisms are associated with obesity, and their interaction. This article provides an overview of current data on the genetics of obesity covering the main provisions of the study of candidate genes, such as PPARG, FABP2, ADRB 2, ADRB3. The role nutrigenetics in the creation of individual programs of weight control and weight loss. But the question of the direct role of genetic factors in the development of obesity remains controversial, since one can not ignore the impact of environmental factors, such as lifestyle, diet, physical activity, stress, and harmful habits. To understand the mechanism of the relationship between genetic factors, environmental factors, and obesity, one needs to carry out research not only on the population level, but also in certain groups of people (ethnic, racial, age.

Modern trends on development of cotton production and processing chain Uzbekistan

OpenAIRE

Abdimumin Alikulov

2010-01-01

The cotton production complex of Uzbekistan has high rating comparing other export oriented branches. Cotton fiber value in 2008 share made 12% from total export of the country. The paper observes some trends and policy developments in cotton industry development.

From Novice to Seasoned Practitioner: a Qualitative Investigation of Genetic Counselor Professional Development.

Science.gov (United States)

Zahm, Kimberly Wehner; Veach, Patricia McCarthy; Martyr, Meredith A; LeRoy, Bonnie S

2016-08-01

Research on genetic counselor professional development would characterize typical developmental processes, inform training and supervision, and promote life-long development opportunities. To date, however no studies have comprehensively examined this phenomenon. The aims of this study were to investigate the nature of professional development for genetic counselors (processes, influences, and outcomes) and whether professional development varies across experience levels. Thirty-four genetic counselors participated in semi-structured telephone interviews exploring their perspectives on their professional development. Participants were sampled from three levels of post-degree genetic counseling experience: novice (0-5 years), experienced (6-14 years), and seasoned (>15 years). Using modified Consensual Qualitative Research and grounded theory methods, themes, domains, and categories were extracted from the data. The themes reflect genetic counselors' evolving perceptions of their professional development and its relationship to: (a) being a clinician, (b) their professional identity, and (c) the field itself. Across experience levels, prevalent influences on professional development were interpersonal (e.g., experiences with patients, genetic counseling colleagues) and involved professional and personal life events. Common developmental experiences included greater confidence and less anxiety over time, being less information-driven and more emotion-focused with patients, delivering "bad news" to patients remains challenging, and individuals' professional development experiences parallel genetic counseling's development as a field. With a few noteworthy exceptions, professional development was similar across experience levels. A preliminary model of genetic counselor professional development is proposed suggesting development occurs in a non-linear fashion throughout the professional lifespan. Each component of the model mutually influences the others, and there

50. Brazilian congress on genetics. 50 years developing genetics. Abstracts

International Nuclear Information System (INIS)

2004-01-01

Use of radioisotopes and ionizing radiations in genetics is presented. Several aspects related to men, animals,plants and microorganisms are reported highlighting biological radiation effects, evolution, mutagenesis and genetic engineering. Genetic mapping, gene mutations, genetic diversity, DNA damages, plant cultivation and plant grow are studied as well

The current state and trends of the development of universities in Ukraine

Directory of Open Access Journals (Sweden)

O.B. Morhulets

2015-09-01

Full Text Available Education is the basis of social, political, economic, spiritual, and cultural development. Therefore, the study of the current state and trends of the development of Ukrainian universities is a significant factor of social and economic progress of the country.The paper reflects the general state of universities in Ukraine, in particular, the trends in dynamics: the number of students in terms of entry/graduation, sources of financing, education fields; the number of universities in the context of accreditation, types and forms of ownership; the number of outbound Ukrainian and inbound foreign students; quantitative and qualitative characteristics of teaching staff; spending on higher education and the cost of funding per student compared with other countries. The purpose of the study is the assessment of economic activity of higher educational establishments in Ukraine, the identification of problems and tendencies of their development in the context of national transformational processes in education and formation of the society of knowledge. The methodical base used in the study is analysis and synthesis, methods of comparison and generalization, extrapolation, index and graphical methods. The practical value of the study is based on the results of a thorough analysis of university activities. Such results reveal the current state and trends of the development of universities under conditions of higher education transformation in Ukraine and its integration into the European educational area. The results of research improve understanding of the state and problems of the universities and provide the foundations for further research in the field of the national education system development and for improving of the quality of young professionals’ training. The trends of the university development indicate that the reorganization of higher education which is being currently taken place, already results in the emergence of new competencies of

Information technology research and development critical trends and issues

CERN Document Server

1985-01-01

Information Technology Research and Development: Critical Trends and Issues is a report of the Office of Technology Assessment of the United States Government on the research and development in the area of information technology. The report discusses information technology research and development - its goals, nature, issues, and strategies; environment and its changes; the roles of the participants; and the health of its field. The book then goes on to four selected case studies in information technology: advanced computer architecture; fiber optic communications; software engineering; and ar

Development trends of the international derivatives market

OpenAIRE

Motorniuk, U.; Terebukh, M.; Kharchuk, V.

2016-01-01

The factors forming international derivatives market trends are researched in this article. The history of the formation of the global derivatives market was analyzed, in particular, events which have led to the growth of the derivatives market. Global derivatives market has revealed major changes in its trends and witnessed the gradual transformation of its structure, observed in recent years. Global derivatives market has revealed major changes in its trends and witnessed the gradual transf...

Socioeconomic status and genetic influences on cognitive development.

Science.gov (United States)

Figlio, David N; Freese, Jeremy; Karbownik, Krzysztof; Roth, Jeffrey

2017-12-19

Accurate understanding of environmental moderation of genetic influences is vital to advancing the science of cognitive development as well as for designing interventions. One widely reported idea is increasing genetic influence on cognition for children raised in higher socioeconomic status (SES) families, including recent proposals that the pattern is a particularly US phenomenon. We used matched birth and school records from Florida siblings and twins born in 1994-2002 to provide the largest, most population-diverse consideration of this hypothesis to date. We found no evidence of SES moderation of genetic influence on test scores, suggesting that articulating gene-environment interactions for cognition is more complex and elusive than previously supposed.

Developing robotic behavior using a genetic programming model

International Nuclear Information System (INIS)

Pryor, R.J.

1998-01-01

This report describes the methodology for using a genetic programming model to develop tracking behaviors for autonomous, microscale robotic vehicles. The use of such vehicles for surveillance and detection operations has become increasingly important in defense and humanitarian applications. Through an evolutionary process similar to that found in nature, the genetic programming model generates a computer program that when downloaded onto a robotic vehicle's on-board computer will guide the robot to successfully accomplish its task. Simulations of multiple robots engaged in problem-solving tasks have demonstrated cooperative behaviors. This report also discusses the behavior model produced by genetic programming and presents some results achieved during the study

Social-emotional development through a behavior genetics lens: infancy through preschool.

Science.gov (United States)

DiLalla, Lisabeth Fisher; Mullineaux, Paula Y; Biebl, Sara J W

2012-01-01

The field of developmental behavior genetics has added significantly to the collective understanding of what factors influence human behavior and human development. Research in this area has helped to explain not only how genes and environment contribute to individual differences but also how the interplay between genes and environment influences behavior and human development. The current chapter provides a background of the theory and methodology behind behavior genetic research and the field of developmental behavior genetics. It also examines three specific developmental periods as they relate to behavior genetic research: infancy, toddlerhood, and early preschool. The behavior genetic literature is reviewed for key socioemotional developmental behaviors that fit under each of these time periods. Temperament, attachment, frustration, empathy, and aggression are behaviors that develop in early life that were examined here. Thus, the general purpose of this chapter is to provide an overview of how genes and environment, as well as the interplay between them, relate to early socioemotional behaviors.

The development of metacognitive-based genetic learning ...

African Journals Online (AJOL)

The development of metacognitive-based genetic learning Instruments at senior ... The results of the research are learning instrument product and textbook whose ... that these instruments have satisfied the criteria: very valid and very ideal.

Trends in Large Proposal Development at Major Research Institutions

Science.gov (United States)

Mulfinger, Lorraine M.; Dressler, Kevin A.; James, L. Eric; Page, Niki; Serrano, Eduardo; Vazquez, Jorge

2016-01-01

Research administrator interest in large research proposal development and submission support is high, arguably in response to the bleak funding landscape for research and federal agency trends toward making more frequent larger awards. In response, a team from Penn State University and Huron Consulting Group initiated a baseline study to…

Population genetics of traditionally managed maize : farming practice as a determinant of genetic structure and identity of maize landraces in Mexico

NARCIS (Netherlands)

Heerwaarden, van J.

2007-01-01

A large amount of crop genetic diversity is being maintained in farmers' fields worldwide. The population genetics of traditionally managed landraces is therefore of interest to the conservation of genetic resources. The growing trend towards agricultural modernization and the prospect of

Short communication Population structure and genetic trends for ...

African Journals Online (AJOL)

user

2016-05-23

May 23, 2016 ... been reported to have negative effects on some production and fitness traits in ..... Drakensberger Handbook 2011, First Edition. www.drakensbergers,co.za ... of National Farm Animal Genetic Resources Management Plans.

Current technological trends in development of NPP systems

International Nuclear Information System (INIS)

Florescu, Gheorghe; Panaitescu, Valeriu

2010-01-01

The recent nuclear research issues look for new technologies and continuous progress in finding different and efficient solutions for sustained and upraising energy demand. The trend of increasing energy consumption and occurring of new and large consumers, especially from Asian countries, imposes finding of new means for clean, large scale and sustained energy production. NPPs availability was continuously monitored and improved; at the same time the safety of the nuclear energy production was under surveillance. The present development of the new technologies, the discoveries of new materials and development of efficient technological processes offer the opportunities for their appropriate implementation and use in the NPP system configurations and functioning/operation. The new technologies and scientific discoveries, and also the international cooperation, offer the opportunities to mitigate the actual barriers in order to cumulate and use advanced energy production, to find new energy sources and to build improved, reliable and safe power plants. The monitoring systems, intelligent sensors and SSCs, nanotechnologies and new/intelligent materials constitute the main ways for improvement of the NPP systems configuration and processes. The paper presents: - The state of the art in the level of the currently applied technologies for nuclear power systems development; - The actual technological limits that need to be over passed for improving the NPP systems ; - The main systems that need improvement and reconfiguration for development of currently operating NPPs as well as raising the operation efficiency, availability and total safety; - The actual energy production issues; - The key arguments in sustaining the R and D new NPP systems development; - Future trends in NPP development; - The limitations in industrial processes knowledge and use. Appropriate R and D in the field of NPP systems have specific characteristics that were considered in paper completion

Statistical Trends and Developments within Inclusive Education in Turkey

Science.gov (United States)

Cakiroglu, Orhan; Melekoglu, Macid Ayhan

2014-01-01

The education of students with special needs in an inclusive environment is becoming more widespread throughout the world. Similarly, in Turkey, the inclusion of students with disabilities has also improved. However, current statistical trends and developments within inclusive education are not well known. The purpose of this study is to provide a…

[Development trend of nanomedicines].

Science.gov (United States)

Kato, Kumiko

2013-01-01

Nanotechnology has had a great impact on science, technology, and society since 2000, and its applications in medicine are also progressing in the diagnosis, treatment, and prevention of disease. In this review, international trends in nanomedicine regulation are introduced, including the definition of nanomedicines and the evaluation of liposomes and iron nanoparticles.

TRENDS IN PRODUCT DEVELOPMENT: CONCURRENT ENGINEERING AND MECHATRONICS

Directory of Open Access Journals (Sweden)

Stefan IANCU

2013-05-01

Full Text Available This paper presents the most significant contemporary trends in new industrial product development:concurrent engineering (CE and mechatronics (M. Author defines what CE and M are, emphasizing whatconnections are between these two concepts, and which are the ways of integration in CE and M. The mainconclusion of this paper is that both these two concepts have known a strongly development in 1975-1985’s,when Information and Communication Technologies (ICT was in full swing of development. The influence ofICT is undoubted, but, from this point of view, there are differences: if M could not be implemented in theabsence of the ICT, communication and computational technologies are not strictly necessary for theimplementation of CE.

Statistical Analysis of Development Trends in Global Renewable Energy

Directory of Open Access Journals (Sweden)

Marina D. Simonova

2016-01-01

Full Text Available The article focuses on the economic and statistical analysis of industries associated with the use of renewable energy sources in several countries. The dynamic development and implementation of technologies based on renewable energy sources (hereinafter RES is the defining trend of world energy development. The uneven distribution of hydrocarbon reserves, increasing demand of developing countries and environmental risks associated with the production and consumption of fossil resources has led to an increasing interest of many states to this field. Creating low-carbon economies involves the implementation of plans to increase the proportion of clean energy through renewable energy sources, energy efficiency, reduce greenhouse gas emissions. The priority of this sector is a characteristic feature of modern development of developed (USA, EU, Japan and emerging economies (China, India, Brazil, etc., as evidenced by the inclusion of the development of this segment in the state energy strategies and the revision of existing approaches to energy security. The analysis of the use of renewable energy, its contribution to value added of countries-producers is of a particular interest. Over the last decade, the share of energy produced from renewable sources in the energy balances of the world's largest economies increased significantly. Every year the number of power generating capacity based on renewable energy is growing, especially, this trend is apparent in China, USA and European Union countries. There is a significant increase in direct investment in renewable energy. The total investment over the past ten years increased by 5.6 times. The most rapidly developing kinds are solar energy and wind power.

Recent trends on crop genetic improvement using mutation techniques

International Nuclear Information System (INIS)

Kang, Siyong

2008-01-01

The radiation breeding technology has been significantly achieved on creation of mutation genetic resources of plants for commercial cultivation and genomic study since 1920s. According to the FAO-IAEA Mutant Variety Database, more than 2600 varieties have been released in the world. Induction of mutations with radiation has been the most frequently used by sources of X-ray and gamma ray, but in recent Japanese scientist have been used the heavy ion beam as a new radiation sources. And China has been made remarkable outcomes in the mutant creation using new space breeding technology since 1990s. In Korea, more about 40 varieties have been developed by using the mutation breeding method since the mid-1960s. Most of the released mutant varieties in Korea were food and oil seed crops, especially for improving agronomic traits such as yield, lodging tolerance, maturity, and functional compounds. Currently the mutation breeding program in Korea has assigned more resources to develop high functional crops and ornamental plants. These functional and ornamental plants are ideal systems for a mutation breeding. A research program for the development of potential varieties of flowering and ornamental crops as rose, chrysanthemum, lily, carnation, orchids, and wild flowers was started with financial support from the Bio green 21 project of Korean government. The potential outcomes from the program will be new highly valued-added varieties which will provide greater money gains to Korean farmers and lots of valued mutants used for a gene isolation of interest and reverse genetics or functional genomic. Scientific interest in mutation breeding has drastically be ed focused to the field of functional genomic. Scientific interest in mutation breeding has drastically be ed focused to the field of functional genomic after a completion of genome sequencing of some model plant species. A direct approach of discovering the function of a novel gene is to use a mutant which has altered

Recent trends on crop genetic improvement using mutation techniques

Energy Technology Data Exchange (ETDEWEB)

Kang, Siyong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-04-15

The radiation breeding technology has been significantly achieved on creation of mutation genetic resources of plants for commercial cultivation and genomic study since 1920s. According to the FAO-IAEA Mutant Variety Database, more than 2600 varieties have been released in the world. Induction of mutations with radiation has been the most frequently used by sources of X-ray and gamma ray, but in recent Japanese scientist have been used the heavy ion beam as a new radiation sources. And China has been made remarkable outcomes in the mutant creation using new space breeding technology since 1990s. In Korea, more about 40 varieties have been developed by using the mutation breeding method since the mid-1960s. Most of the released mutant varieties in Korea were food and oil seed crops, especially for improving agronomic traits such as yield, lodging tolerance, maturity, and functional compounds. Currently the mutation breeding program in Korea has assigned more resources to develop high functional crops and ornamental plants. These functional and ornamental plants are ideal systems for a mutation breeding. A research program for the development of potential varieties of flowering and ornamental crops as rose, chrysanthemum, lily, carnation, orchids, and wild flowers was started with financial support from the Bio green 21 project of Korean government. The potential outcomes from the program will be new highly valued-added varieties which will provide greater money gains to Korean farmers and lots of valued mutants used for a gene isolation of interest and reverse genetics or functional genomic. Scientific interest in mutation breeding has drastically be ed focused to the field of functional genomic. Scientific interest in mutation breeding has drastically be ed focused to the field of functional genomic after a completion of genome sequencing of some model plant species. A direct approach of discovering the function of a novel gene is to use a mutant which has altered

Reframing E-Government Development Indices with Respect to New Trends in ICT

Directory of Open Access Journals (Sweden)

Máchová Renáta

2015-12-01

Full Text Available E-government readiness is an important indicator of the quality of a country’s technological and telecommunication infrastructure and the ability of its citizens, businesses and governments to adopt, use and benefit from modern technologies. To measure and compare selected countries, a lot of benchmarking and ranking indices have been introduced since the beginning of the century. With the increasing importance of trends such as cloud computing, open (big data, participation tools or social media, new indicators and approaches need to be introduced in the measuring of the e-government development, and the existing indices should to be updated, redefined and restructured. Therefore, this article explores the structure of the existing e-government development indices to show the main indicators and trends. Then, it proposes and implements a new framework to evaluate e-government development using these new trends in ICT. It also examines and compares a basic background on the e-government development, benefits and risks of cloud computing, open (big data and participation tools in the public sector. Based on the newly proposed framework, the e-government development index is calculated for each EU Member State to clearly identify the indicators to have an influence on the e-government development. In the last part, these results are compared to the already existing indices to validate the conformity of the rank methods using Kendall rank correlation coefficient.

The genetic framework for development of nephrolithiasis

Directory of Open Access Journals (Sweden)

Vinaya Vasudevan

2017-01-01

Full Text Available Over 1%–15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge; however, several candidate genes have been implicated in the development of nephrolithiasis. In this review, we will review current data on the genetic inheritance of stone disease, as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis.

Cell Factory Stability and Genetic Circuits for Improved Strain Development

DEFF Research Database (Denmark)

Rugbjerg, Peter

. However, all synthetic gene systems -­ including the target metabolic pathways themselves -­ represent a possible fitness burden to the cell and thus constitute a threat to strain stability. In this thesis, several studies served to develop genetic systems for optimizing cell factory development...... systems can challenge the stability of strain designs. A metabolite-­producing Escherichia coli strain was long-­term cultured to study production stability and the dynamic effects of mutations within the cell population. A genetic error landscape of pathway disruptions was identified including particular......Development of new chemical-­‐producing microbial cell factories is an iterative trial-­and-­error process, and to screen candidate cells at high throughput, genetic biosensor systems are appealing. Each biosensor has distinct biological parameters, making modular tuning networks attractive...

Genetic engineering in nonhuman primates for human disease modeling.

Science.gov (United States)

Sato, Kenya; Sasaki, Erika

2018-02-01

Nonhuman primate (NHP) experimental models have contributed greatly to human health research by assessing the safety and efficacy of newly developed drugs, due to their physiological and anatomical similarities to humans. To generate NHP disease models, drug-inducible methods, and surgical treatment methods have been employed. Recent developments in genetic and developmental engineering in NHPs offer new options for producing genetically modified disease models. Moreover, in recent years, genome-editing technology has emerged to further promote this trend and the generation of disease model NHPs has entered a new era. In this review, we summarize the generation of conventional disease model NHPs and discuss new solutions to the problem of mosaicism in genome-editing technology.

Genetic influences on the development of fibrosis in Crohn’s Disease

Directory of Open Access Journals (Sweden)

Bram eVerstockt

2016-05-01

Full Text Available Fibrostenotic strictures are an important complication in patients with Crohn’s Disease, very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual, and is influenced by an interplay with environmental, immunological and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here we review the genetic factors that have been associated with the development of fibrosis in patients with Crohn’s disease, as well as their potential pathophysiological mechanism(s. We also hypothesize on clinical implications if any, and future research directions.

Open Science: Trends in the Development of Science Learning

Science.gov (United States)

Scanlon, Eileen

2011-01-01

This article comments on some trends in the evolution of science teaching at a distance using the Open University UK (OU UK) experience as a benchmark. Even from the first years of the university there was an understanding of the potential role for media in developing methods for teaching science at a distance, in particular the potential for…

Whole genome amplification in preimplantation genetic diagnosis*

Science.gov (United States)

Zheng, Ying-ming; Wang, Ning; Li, Lei; Jin, Fan

2011-01-01

Preimplantation genetic diagnosis (PGD) refers to a procedure for genetically analyzing embryos prior to implantation, improving the chance of conception for patients at high risk of transmitting specific inherited disorders. This method has been widely used for a large number of genetic disorders since the first successful application in the early 1990s. Polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH) are the two main methods in PGD, but there are some inevitable shortcomings limiting the scope of genetic diagnosis. Fortunately, different whole genome amplification (WGA) techniques have been developed to overcome these problems. Sufficient DNA can be amplified and multiple tasks which need abundant DNA can be performed. Moreover, WGA products can be analyzed as a template for multi-loci and multi-gene during the subsequent DNA analysis. In this review, we will focus on the currently available WGA techniques and their applications, as well as the new technical trends from WGA products. PMID:21194180

Genetic Influences on the Development of Fibrosis in Crohn's Disease

OpenAIRE

Verstockt, Bram; Cleynen, Isabelle

2016-01-01

Fibrostenotic strictures are an important complication in patients with Crohn’s disease (CD), very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual and is influenced by an interplay with environmental, immunological, and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here, we revi...

Nuclear power in the world: Its present status and development trends

International Nuclear Information System (INIS)

Bennett, L.L.

1994-01-01

Present status of nuclear power development in the world is presented showing data on power reactors in operation and under construction, on growth of nuclear electricity generation since 1970, the distribution of nuclear electricity generation during 1993. Development trends in the field are also outlined. 7 figs, 5 tabs

Developing education tailored to clinical roles: genetics education for haemophilia nurses.

Science.gov (United States)

Burke, Sarah; Barker, Colin; Marshall, Dianne

2012-01-01

Genetics is an important component of the clinical work of haemophilia nurses, but little was known about the genetic education needs of haemophilia nurses. To develop, deliver and evaluate genetic education for haemophilia nurses, based on clinical roles. Perceived relevance of genetics to haemophilia nursing practice was explored using electronic voting (response rate 75%, 58/77). A follow-on questionnaire to a volunteer sample of participants explored educational preferences (response rate 41%, 17/41). Results informed development of a two-hour genetics workshop session, evaluated by questionnaire (response rate 67%, 47/70). Genetic competences were considered relevant to the clinical practice of haemophilia nurses, and learning needs were identified. Preference was expressed for education focused on practical skills. During the subsequent workshop, participant confidence ratings significantly increased in the four areas addressed. Planned changes to clinical care and training were reported. Within new areas of advanced nursing practice, learning needs can be addressed by: identifying relevant clinical activities and associated learning needs; creating a strategy and resources using preferred forms of delivery; implementing the strategy; and evaluating its effect. This will enable development of education that addresses the real needs of practising nurses, grounded in their daily clinical practice. Copyright © 2011 Elsevier Ltd. All rights reserved.

Trends in the development of confectionery technology

Directory of Open Access Journals (Sweden)

Z. A. Kanarskaya

2016-01-01

Full Text Available Nutrition is one of the main factors that have an enormous impact on the health, performance, creativity, activity and life expectancy, as all essential nutrients enter the body is food. Nutrients are transformed by metabolism in the structural elements of the cell, providing the necessary human plastic material and energy. The traditional source of important nutrients for the human body are the pastries, which are in our population is very popular. However, confectionery products is inherent drawback. Excessive consumption of flour confectionery goods violated balanced diets on nutrients and energy value. This is due to a high fat, carbohydrates, and low enough in some cases, complete absence of fiber, minerals and vitamins. In connection with the formation of the system of healthy nutrition of the population requires the development of production technology of confectionery products with the introduction in their structure of functional ingredients, do not change the organoleptic properties of the product, but can help reduce caloric properties of food and the taste of Tatar national. The purpose of this survey – to identify trends in the development of confectionery technology. This review shows that in confectionery production technology to reduce calories and increase the biological value of the replacement trend in the formulations of wheat flour on chickpeas, flax, triticale, sorghum, rice, barley, corn, bird cherry. It is noted that in the recipes for cakes confectionery introduced from non-traditional raw materials containing dietary fiber. It determined to be a gluten-free medical and functional confectionery products for people with celiac disease.

Guidelines for collecting and maintaining archives for genetic monitoring

Science.gov (United States)

Jackson, Jennifer A.; Laikre, Linda; Baker, C. Scott; Kendall, Katherine C.; ,

2012-01-01

Rapid advances in molecular genetic techniques and the statistical analysis of genetic data have revolutionized the way that populations of animals, plants and microorganisms can be monitored. Genetic monitoring is the practice of using molecular genetic markers to track changes in the abundance, diversity or distribution of populations, species or ecosystems over time, and to follow adaptive and non-adaptive genetic responses to changing external conditions. In recent years, genetic monitoring has become a valuable tool in conservation management of biological diversity and ecological analysis, helping to illuminate and define cryptic and poorly understood species and populations. Many of the detected biodiversity declines, changes in distribution and hybridization events have helped to drive changes in policy and management. Because a time series of samples is necessary to detect trends of change in genetic diversity and species composition, archiving is a critical component of genetic monitoring. Here we discuss the collection, development, maintenance, and use of archives for genetic monitoring. This includes an overview of the genetic markers that facilitate effective monitoring, describes how tissue and DNA can be stored, and provides guidelines for proper practice.

Conrad Waddington and the Marriage of Genetics, Development ...

Indian Academy of Sciences (India)

C H Waddington was an important figure in the early days of linking development and the genetics of development with the study of evolution. There had been great advances in embryology from the 19th century onwards and going well into the 20th. It all started with the simple description of the development of a wide ...

Development of a microsatellite primer set to investigate the genetic ...

Indian Academy of Sciences (India)

Development of a microsatellite primer set to investigate the genetic population structure of Armadillidium nasatum (Crustacea, Oniscidea). Séverine Masson, Cédric Faivre, Isabelle Giraud, Catherine Souty-Grosset, Richard Cordaux, Carine Delaunay,. Didier Bouchon and Nicolas Bech. J. Genet. 93, 545-549. Table 1.

Research and Technology Development for Genetic Improvement of Switchgrass

Energy Technology Data Exchange (ETDEWEB)

Kausch, Albert [Univ. of Rhode Island, Kingston, RI (United States); Rhodes, Richard [Univ. of Rhode Island, Kingston, RI (United States)

2017-05-02

This research adds to the understanding of switchgrass genetics and the increasing of biomass relevant to production of bioenergy. Switchgrass, Panicum virgatum L., and its related species are well known as potential bioenergy crops since the early 1990s. There are global economic, political, US national security and environmental pressures to increase renewable biofuel production and utilization to offset gasoline and diesel fuel use and climate change, especially in the liquid fuel transportation sector. To realize the potential of bioenergy crops, rapid genetic improvement of the most promising perennial grass feedstocks, such as switchgrass, are anticipated by current genomics, association genetics, marker assisted breeding, hybrid plant development, advanced tissue culture, conventional genetics and other approaches to increase yield, processability, and regional adaptation. The technical effectiveness and economic feasibility of the methods or techniques investigated are demonstrated by several publications, presentations and patents produced as an outcome and deliverable of this research. This project is of a broad benefit to the public not only through the dissemination of this information but also to the development of new methods which will be applied to future bioenergy crop improvement as well as other crops.

Genetic Regulation of Embryological Limb Development with Relation to Congenital Limb Deformity in Humans

OpenAIRE

Barham, Guy; Clarke, Nicholas M. P.

2008-01-01

Over the last 15 years, great improvements in genetic engineering and genetic manipulation strategies have led to significant advances in the understanding of the genetics governing embryological limb development. This field of science continues to develop, and the complex genetic interactions and signalling pathways are still not fully understood. In this review we will discuss the roles of the principle genes involved in the three-dimensional patterning of the developing limb and will discu...

Radiation genetics. Status and prospects

International Nuclear Information System (INIS)

Svyatova, G.S.; Abil'dinova, G.Zh.; Berezina, G.M.

1997-01-01

In Republic of Kazakhstan on the base of Republican Scientific and Research Center for Mother and Child Health Protection the comprehensive medical-genetical testing of rural population living in immediate proximity from Semipalatinsk test site is carried out. Besides of general medical-genetic characteristics of examined population the frequency and structure of congenital diseases of newborns from 1970 to 1995 were determined. 67.5 thousand parturitions outcomes in researched area and 21.5 thousand ones in control district (Akmola region) are studied. Both the frequency and the structure of chromosomal aberration of population living on contaminated by radionuclides territories is researched as well. Perspective trends in field of clinical radiation genetics are outlined, there are as follows: - application of early diagnostics and prophylaxis of radiation-induced pathology of both the stochastic and nonstochastic characters; - conducting of biologic dosimetry; - wide application of peri-conception prophylaxis of genetic disorders; - application of anti-mutagens and special food-stuffs making for both the reducing of the absorption and the accumulation of radionuclides in organism; - introduction of long-term programs of correction of developing pathologies caused by multifactorial influence of environment

Radiation mutagenesis in development of genetic fundamentals of cotton selection

International Nuclear Information System (INIS)

Musaev, D.A.; Almatov, A.S.

1987-01-01

Some results of investigations on preparation and genetic analysis of mutants in inbreeding lines of genetic collections of cotton plants, as well as problems on mutant application in practical selection are covered. The results show that the scientific authenticity and efficiency of fundamental and applied investigations in the field of experimental mutagenesis of cotton plants,being a facultative self-polinator, depend on keeping necessary methodical requirements. Application of inbreeding lines of genetic collection with marker features as the initial material, isolation of plants usinng self-polination of flowers on all stages of investigation are related to these requirements. Several methodical recommendations on genetic-selective investigations are developed

On the Nature of Trends

DEFF Research Database (Denmark)

Mackinney-Valentin, Maria

2010-01-01

A consolidation of the field Trend Studies through mapping, updating and developing trend theory.......A consolidation of the field Trend Studies through mapping, updating and developing trend theory....

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

Directory of Open Access Journals (Sweden)

Rahul S Desikan

2017-03-01

Full Text Available Identifying individuals at risk for developing Alzheimer disease (AD is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction.Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1, we identified AD-associated SNPs (at p < 10-5. We then integrated these AD-associated SNPs into a Cox proportional hazard model using genotype data from a subset of 6,409 AD patients and 9,386 older controls from Phase 1 of the Alzheimer's Disease Genetics Consortium (ADGC, providing a polygenic hazard score (PHS for each participant. By combining population-based incidence rates and the genotype-derived PHS for each individual, we derived estimates of instantaneous risk for developing AD, based on genotype and age, and tested replication in multiple independent cohorts (ADGC Phase 2, National Institute on Aging Alzheimer's Disease Center [NIA ADC], and Alzheimer's Disease Neuroimaging Initiative [ADNI], total n = 20,680. Within the ADGC Phase 1 cohort, individuals in the highest PHS quartile developed AD at a considerably lower age and had the highest yearly AD incidence rate. Among APOE ε3/3 individuals, the PHS modified expected age of AD onset by more than 10 y between the lowest and highest deciles (hazard ratio 3.34, 95% CI 2.62-4.24, p = 1.0 × 10-22. In independent cohorts, the PHS strongly predicted empirical age of AD onset (ADGC Phase 2, r = 0.90, p = 1.1 × 10-26 and longitudinal progression from normal aging to AD (NIA ADC, Cochran-Armitage trend test, p = 1.5 × 10-10, and was associated with neuropathology (NIA ADC, Braak stage of neurofibrillary tangles, p = 3.9 × 10-6, and Consortium to Establish a Registry for Alzheimer's Disease score for neuritic plaques, p = 6.8 × 10-6 and in vivo markers of AD neurodegeneration (ADNI

Developing close combat behaviors for simulated soldiers using genetic programming techniques.

Energy Technology Data Exchange (ETDEWEB)

Pryor, Richard J.; Schaller, Mark J.

2003-10-01

Genetic programming is a powerful methodology for automatically producing solutions to problems in a variety of domains. It has been used successfully to develop behaviors for RoboCup soccer players and simple combat agents. We will attempt to use genetic programming to solve a problem in the domain of strategic combat, keeping in mind the end goal of developing sophisticated behaviors for compound defense and infiltration. The simplified problem at hand is that of two armed agents in a small room, containing obstacles, fighting against each other for survival. The base case and three changes are considered: a memory of positions using stacks, context-dependent genetic programming, and strongly typed genetic programming. Our work demonstrates slight improvements from the first two techniques, and no significant improvement from the last.

MODERN TRENDS OF DEVELOPMENT OF INTERNATIONAL DERIVATIVES MARKET

Directory of Open Access Journals (Sweden)

V. Shelydko

2014-09-01

Full Text Available Article is devoted to analysis of structure and peculiarities of development of the international derivatives market. The history of formation of the international derivatives market is investigated. The nature, functions and advantages of use of derivatives, and also their role in the modern international securities market are defined. Classification of financial derivatives is considered. Product lines of financial derivatives are analyzed. The regional structure of the international derivatives market and dynamics of its development are investigated. The comparative characteristic of volumes and structure of exchange and over-the-counter segments of international derivatives market are carried out. Dynamics and structure of international markets of interest-bearing derivatives and currency derivatives are analyzed. The fundamental trends of development of the modern international derivatives market are defined.

Trends in genome-wide and region-specific genetic diversity in the Dutch-Flemish Holstein-Friesian breeding program from 1986 to 2015.

Science.gov (United States)

Doekes, Harmen P; Veerkamp, Roel F; Bijma, Piter; Hiemstra, Sipke J; Windig, Jack J

2018-04-11

In recent decades, Holstein-Friesian (HF) selection schemes have undergone profound changes, including the introduction of optimal contribution selection (OCS; around 2000), a major shift in breeding goal composition (around 2000) and the implementation of genomic selection (GS; around 2010). These changes are expected to have influenced genetic diversity trends. Our aim was to evaluate genome-wide and region-specific diversity in HF artificial insemination (AI) bulls in the Dutch-Flemish breeding program from 1986 to 2015. Pedigree and genotype data (~ 75.5 k) of 6280 AI-bulls were used to estimate rates of genome-wide inbreeding and kinship and corresponding effective population sizes. Region-specific inbreeding trends were evaluated using regions of homozygosity (ROH). Changes in observed allele frequencies were compared to those expected under pure drift to identify putative regions under selection. We also investigated the direction of changes in allele frequency over time. Effective population size estimates for the 1986-2015 period ranged from 69 to 102. Two major breakpoints were observed in genome-wide inbreeding and kinship trends. Around 2000, inbreeding and kinship levels temporarily dropped. From 2010 onwards, they steeply increased, with pedigree-based, ROH-based and marker-based inbreeding rates as high as 1.8, 2.1 and 2.8% per generation, respectively. Accumulation of inbreeding varied substantially across the genome. A considerable fraction of markers showed changes in allele frequency that were greater than expected under pure drift. Putative selected regions harboured many quantitative trait loci (QTL) associated to a wide range of traits. In consecutive 5-year periods, allele frequencies changed more often in the same direction than in opposite directions, except when comparing the 1996-2000 and 2001-2005 periods. Genome-wide and region-specific diversity trends reflect major changes in the Dutch-Flemish HF breeding program. Introduction of

Ancestry and dental development: A geographic and genetic perspective.

Science.gov (United States)

Dhamo, Brunilda; Kragt, Lea; Grgic, Olja; Vucic, Strahinja; Medina-Gomez, Carolina; Rivadeneira, Fernando; Jaddoe, Vincent W V; Wolvius, Eppo B; Ongkosuwito, Edwin M

2018-02-01

In this study, we investigated the influence of ancestry on dental development in the Generation R Study. Information on geographic ancestry was available in 3,600 children (1,810 boys and 1,790 girls, mean age 9.81 ± 0.35 years) and information about genetic ancestry was available in 2,786 children (1,387 boys and 1,399 girls, mean age 9.82 ± 0.34 years). Dental development was assessed in all children using the Demirjian method. The associations of geographic ancestry (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani vs Dutch as the reference group) and genetic content of ancestry (European, African or Asian) with dental development was analyzed using linear regression models. In a geographic perspective of ancestry, Moroccan (β = 0.18; 95% CI: 0.07, 0.28), Turkish (β = 0.22; 95% CI: 0.12, 0.32), Dutch Antillean (β = 0.27; 95% CI: 0.12, 0.41), and Surinamese Creole (β = 0.16; 95% CI: 0.03, 0.30) preceded Dutch children in dental development. Moreover, in a genetic perspective of ancestry, a higher proportion of European ancestry was associated with decelerated dental development (β = -0.32; 95% CI: -.44, -.20). In contrast, a higher proportion of African ancestry (β = 0.29; 95% CI: 0.16, 0.43) and a higher proportion of Asian ancestry (β = 0.28; 95% CI: 0.09, 0.48) were associated with accelerated dental development. When investigating only European children, these effect estimates increased to twice as large in absolute value. Based on a geographic and genetic perspective, differences in dental development exist in a population of heterogeneous ancestry and should be considered when describing the physiological growth in children. © 2017 The Authors American Journal of Physical Anthropology Published by Wiley Periodicals, Inc.

Gender Development Research in Sex Roles: Historical Trends and Future Directions.

Science.gov (United States)

Zosuls, Kristina M; Miller, Cindy Faith; Ruble, Diane N; Martin, Carol Lynn; Fabes, Richard A

2011-06-01

The late 1960s through the 1970s marked an important turning point in the field of gender research, including theory and research in gender development. The establishment of Sex Roles in 1975 as a forum for this research represented an important milestone in the field. In this article, we celebrate the 35th anniversary of Sex Roles and, in particular, its contributions to the field of research on children's and adolescents' gender development. We examine the trends in research on gender development published in Sex Roles since its inception and use this analysis as a vehicle for exploring how the field has grown and evolved over the past few decades. We begin with a brief review of the history of this field of research since 1975. Then, we present a descriptive assessment of articles published on gender development in Sex Roles over time, and link this assessment to general trends that have occurred in the study of gender development over the past 35 years. We conclude with a discussion of future directions for the field of gender development. In particular, we highlight areas in which the journal could play a role in promoting more diversity in topics, methods, and ages employed in gender development research.

Gender Development Research in Sex Roles: Historical Trends and Future Directions

Science.gov (United States)

Miller, Cindy Faith; Ruble, Diane N.; Martin, Carol Lynn; Fabes, Richard A.

2011-01-01

The late 1960s through the 1970s marked an important turning point in the field of gender research, including theory and research in gender development. The establishment of Sex Roles in 1975 as a forum for this research represented an important milestone in the field. In this article, we celebrate the 35th anniversary of Sex Roles and, in particular, its contributions to the field of research on children’s and adolescents’ gender development. We examine the trends in research on gender development published in Sex Roles since its inception and use this analysis as a vehicle for exploring how the field has grown and evolved over the past few decades. We begin with a brief review of the history of this field of research since 1975. Then, we present a descriptive assessment of articles published on gender development in Sex Roles over time, and link this assessment to general trends that have occurred in the study of gender development over the past 35 years. We conclude with a discussion of future directions for the field of gender development. In particular, we highlight areas in which the journal could play a role in promoting more diversity in topics, methods, and ages employed in gender development research. PMID:21747580

Tianshuishi space breeding current situation and developing trend

International Nuclear Information System (INIS)

Wang Fuquan; Song Jianrong; Zhang Zhongping; Guo Zhenfang

2012-01-01

Tianshuishi is located in Xi'an to lanzhou among two big cities, the five space launch, has vegetables, food, grasses, flowers, rape, melon and fruit, Chinese traditional medicine, amount of 8 categories of crops, such as the 22 new material after carrying the ground breeding work. Only vegetables on identified 23 aerospace new varieties. After ten years of space breeding, summarizes the present situation of Tianshuishi space breeding, development experience, characteristic, trends, and puts forward the development space breeding Tianshuishi organization and breeding of talent from the matching policy and grow up incentive mechanism, strengthen the cooperation and all over the country, establishing fiscal policy support from the aspects such as advice. (authors)

Molecular genetics of pituitary development in zebrafish.

Science.gov (United States)

Pogoda, Hans-Martin; Hammerschmidt, Matthias

2007-08-01

The pituitary gland of vertebrates consists of two major parts, the neurohypophysis (NH) and the adenohypophysis (AH). As a central part of the hypothalamo-hypophyseal system (HHS), it constitutes a functional link between the nervous and the endocrine system to regulate basic body functions, such as growth, metabolism and reproduction. The development of the AH has been intensively studied in mouse, serving as a model for organogenesis and differential cell specification. However, given that the AH is a relatively recent evolutionary advance of the chordate phylum, it is also interesting to understand its development in lower chordate systems. In recent years, the zebrafish has emerged as a powerful lower vertebrate system for developmental studies, being amenable for large-scale genetic approaches, embryological manipulations, and in vivo imaging. Here, we present an overview of current knowledge of the mechanisms and genetic control of pituitary formation during zebrafish development. First, we describe the components of the zebrafish HHS, and the different pituitary cell types and hormones, followed by a description of the different steps of normal pituitary development. The central part of the review deals with the genes found to be essential for zebrafish AH development, accompanied by a description of the corresponding mutant phenotypes. Finally, we discuss future directions, with particular focus on evolutionary aspects, and some novel functional aspects with growing medical and social relevance.

CURRENT TRENDS FOR DEVELOPMENT AND IMPROVEMENT OF THE ORGANIZATIONAL STRUCTURES IN MANAGEMENT

Directory of Open Access Journals (Sweden)

Angel Doraliyski

2017-03-01

Full Text Available One of the key components of the management system is the organizational structure of management. This report presents the current trends of development and improvement of organizational structures of management. The semantics of the term "organizational structure" used in the report is clarified. Key aspects of structural policy of organizations are discussed, as well as the introduction of flexible organizational forms. The main directions for analysis of organizational policy of organizations are also mentioned. It is stressed that the analysis of current trends for the future development of organizational structures of management should be an integral component of the management policy of every organization. The trends are flexibility and adaptability of the organizational structure, rational proportion between centralization and decentralization, an appropriate balance between the rights, duties and responsibilities, reducing regulations, rules and other normative documents. A recommendetaion is made that organizational governance structures must be adapted constantly in accordance with changes in the overall management system, as they are one of its main components.

Review:Whole genome amplification in preimplantation genetic diagnosis

Institute of Scientific and Technical Information of China (English)

Ying-ming ZHENG; Ning WANG; Lei LI; Fan JIN

2011-01-01

Preimplantation genetic diagnosis(PGD)refers to a procedure for genetically analyzing embryos prior to implantation,improving the chance of conception for patients at high risk of transmitting specific inherited disorders.This method has been widely used for a large number of genetic disorders since the first successful application in the early 1990s.Polymerase chain reaction(PCR)and fluorescent in situ hybridization(FISH)are the two main methods in PGD,but there are some inevitable shortcomings limiting the scope of genetic diagnosis.Fortunately,different whole genome amplification(WGA)techniques have been developed to overcome these problems.Sufficient DNA can be amplified and multiple tasks which need abundant DNA can be performed.Moreover,WGA products can be analyzed as a template for multi-loci and multi-gene during the subsequent DNA analysis.In this review,we will focus on the currently available WGA techniques and their applications,as well as the new technical trends from WGA products.

Recent developments in the genetics of schizophrenia.

Science.gov (United States)

Shastry, B S

1999-09-01

Schizophrenia, which is also called "split personality," is a complex and multifactorial mental disorder with variable clinical manifestations. It perhaps represents several diseases and occurs throughout the world. It is a more-prevalent disorder among homeless people and is clinically characterized by hallucinations and delusions. The pathophysiology of schizophrenia is not localized to a single region of the brain and the etiology of this illness is not understood. Because of its complex pattern of inheritance, genetic techniques are not readily applicable in identifying the genes responsible for this disorder. Family, twin, and adoption studies, however, provide strong but indirect support for genetic components in the etiology of schizophrenia. Extensive linkage analyses now suggest that susceptibility genes may be present on chromosomes 5q, 6p, 8p, 13q, 18p, and 22q. Identification and characterization of these and other genes, as well as non-genetic factors, is one of the greatest challenges in biomedicine. This may ultimately lead to the development of a new line of effective and safe drugs or treatments for its prevention or cure.

Trend curve data development and testing

International Nuclear Information System (INIS)

McElroy, W.N.; Gold, R.; Simons, R.L.; Roberts, J.H.

1986-08-01

Existing trend curves do not account for previous and more recently observed test and power reactor flux-level, thermal neutron and gamma-ray field-induced effects. Any agreement between measured data and trend curve predictions that does not adequately represent the important neutron environmental and temperature effects as well as the microstructural damage processes, therefore, could be fortuitous. Two principal questions asked concerning the metallurgical condition of the pressure vessel and its support structures are: What are the controlling variables; and What effects do they have on changing the metallurgical properties of the vessel and its support structures throughout their lifetimes

Integrating text mining, data mining, and network analysis for identifying genetic breast cancer trends.

Science.gov (United States)

Jurca, Gabriela; Addam, Omar; Aksac, Alper; Gao, Shang; Özyer, Tansel; Demetrick, Douglas; Alhajj, Reda

2016-04-26

Breast cancer is a serious disease which affects many women and may lead to death. It has received considerable attention from the research community. Thus, biomedical researchers aim to find genetic biomarkers indicative of the disease. Novel biomarkers can be elucidated from the existing literature. However, the vast amount of scientific publications on breast cancer make this a daunting task. This paper presents a framework which investigates existing literature data for informative discoveries. It integrates text mining and social network analysis in order to identify new potential biomarkers for breast cancer. We utilized PubMed for the testing. We investigated gene-gene interactions, as well as novel interactions such as gene-year, gene-country, and abstract-country to find out how the discoveries varied over time and how overlapping/diverse are the discoveries and the interest of various research groups in different countries. Interesting trends have been identified and discussed, e.g., different genes are highlighted in relationship to different countries though the various genes were found to share functionality. Some text analysis based results have been validated against results from other tools that predict gene-gene relations and gene functions.

Genetic variation in WRN and ischemic stroke

DEFF Research Database (Denmark)

Christoffersen, Mette; Frikke-Schmidt, Ruth; Nordestgaard, Børge G.

2017-01-01

trends for ischemic cerebrovascular disease (P = 0.06). In meta-analyses including 59,190 individuals in 5 studies, the hazard ratio for ischemic stroke for C1367R TT homozygotes versus CC/CT was 1.14 (1.04–1.25; P = 0.008). Conclusions This study suggests that common genetic variation in WRN......Background Werner syndrome, a premature genetic aging syndrome, shares many clinical features reminiscent of normal physiological aging, and ischemic vascular disease is a frequent cause of death. We tested the hypothesis that genetic variation in the WRN gene was associated with risk of ischemic...... vascular disease in the general population. Methods We included 58,284 participants from two general population cohorts, the Copenhagen City Heart Study (CCHS) and the Copenhagen General Population Study (CGPS). Of these, 6,312 developed ischemic vascular disease during follow-up. In the CCHS (n = 10...

Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices

Directory of Open Access Journals (Sweden)

Wolyniak MJ

2015-10-01

Full Text Available Michael J Wolyniak,1 Lynne T Bemis,2 Amy J Prunuske2 1Department of Biology, Hampden-Sydney College, Hampden-Sydney, VA, 2Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA Abstract: Genetics is an essential subject to be mastered by health professional students of all types. However, technological advances in genomics and recent pedagogical research have changed the way in which many medical training programs teach genetics to their students. These advances favor a more experience-based education focused primarily on developing student's critical thinking skills. In this review, we examine the current state of genetics education at both the preclinical and clinical levels and the ways in which medical and pedagogical research have guided reforms to current and emerging teaching practices in genetics. We discover exciting trends taking place in which genetics is integrated with other scientific disciplines both horizontally and vertically across medical curricula to emphasize training in scientific critical thinking skills among students via the evaluation of clinical evidence and consultation of online databases. These trends will produce future health professionals with the skills and confidence necessary to embrace the new tools of medical practice that have emerged from scientific advances in genetics, genomics, and bioinformatics. Keywords: genetics education, medical genetics, pedagogical practice, active learning, problem-based learning

Radiation application on development of marker genes for genetic manipulation

International Nuclear Information System (INIS)

Lee, Young Il

1997-04-01

This state of art report was dealt with the recent progress of genetic engineering techniques and prospect of gene manipulation. Especially the selection of new genetic marker genes such as variants to environmental stress, pest or insect resistance, herbicide resistance and nutritional requirement was reviewed by using plant cell and tissue culture combined with radiation mutation induction. Biotechnology has taken us from the era hybrid plants to the era of transgenic plants. Although there are still many problems to solve in transformation method and the regeneration of transformed cell and tissue. Genetic marker genes are very important material to improve the technique of genetic manipulation. Most of the genes have been developed by radiation. (author). 180 refs., 6 tabs

Research on Current Trends and Developments in Library Automation Systems.

Science.gov (United States)

Clyde, Laurel A.

A research project was undertaken in 1992 in order to identify, describe, and analyze current trends and developments in library automation systems and library software. The starting point is work conducted in 1988/1989 that formed the foundation of the book "Computer Software for School Libraries: A Directory." A 1992 survey of software…

Foundation on Economic Trends v. Bowen.

Science.gov (United States)

1989-10-04

The National Enviromental Policy Act requires that government agencies make a detailed enviromental impact statement (EIS) for all research significantly affecting the environment. These statements must be supplemented if the project substantially changes or if new information is obtained. The Foundation on Economic Trends argued that three developments in recombinant DNA research will significantly alter the enviromental impact, thereby mandating a new EIS by the National Institutes of Health (NIH). These developments are cloning oncogenic viruses, engineering the human immunodeficiency virus into cells not normally susceptible to it, and introducing AIDS genetic codes into mice. The U.S. District Court, District of Columbia, held that the first two projects do not pose a greater risk and that the enviromental assessment being prepared by NIH on the third satisfies the requirements of the National Enviromental Policy Act.

Modern trends in theoretical radiation chemistry development

International Nuclear Information System (INIS)

Kaplan, I.G.

1983-01-01

Most important trends in the development of radiation chemitry theory are considered. Wide use of electronic computers for modeling different stages of radiolysis in conjUnction with advanced precision experimental methods (picosecond pulse radiolysis, acceptor additions method, magnetic method of detecting interstitial active particles) is noted. Information obtained in photochemistry and molecular spectroscopy, including laser photolysis, is in common use in developing the theory. It is noted that data on the processes occurring within less than 10 -12 s time can be obtained now only on the base of theoretical representations about the mechanism of ionizing irradiation interaction with molecular medium. Therefore, special attention in the review is paid to investigation of primary radiolysis processes. Besides investigation of primary medium excitation processes theoretical investigations into the ways of energy degradation, knocked out electrons and their further state are continued. It is noted that a considerable number of papers deal with the nature and behaviour of radiation-induced excess electrons in non-polar solutions and solid matrices. Works on application of diffusion kinetics in radiolysis have been developed in recent years

Online Marketing Trends

OpenAIRE

Horecká, Ivana

2015-01-01

This thesis deals with online marketing trends. Its main goal is to define the latest online marketing trends, create a website with the free online marketing trends, and analyse their effectiveness. The theoretical part brings a thorough description of the latest online marketing trends. Moreover, it provides an insight into the latest trends in the website development. The chosen online marketing trends defined in the theoretical part are subsequently applied on a newly created website. All...

Energy Trends 2012; Energie Trends 2012

Energy Technology Data Exchange (ETDEWEB)

Van Dril, T. (ed.); Gerdes, J. (ed.) [ECN Beleidsstudies, Petten (Netherlands); Marbus, S. (ed.) [Energie-Nederland, Den Haag (Netherlands); Boelhouwer, M. (ed.) [Netbeheer Nederland, Arnhem (Netherlands)

2012-11-15

In Energy Trends 2012, all figures and developments in the field of energy in the Netherlands are presented in conjunction. The book provides information on energy use by consumers and businesses, provides insight into the international energy trade, energy production and development of energy networks [Dutch] In Energie Trends 2012 staan alle cijfers en ontwikkelingen op het gebied van energie in Nederland in samenhang gepresenteerd. Het boek biedt informatie over energiegebruik door consumenten en bedrijven, geeft inzage in de internationale energiehandel en energieproductie en biedt inzicht in de ontwikkeling van de energienetten.

Effect of genetic polymorphisms on development of gout.

Science.gov (United States)

Urano, Wako; Taniguchi, Atsuo; Inoue, Eisuke; Sekita, Chieko; Ichikawa, Naomi; Koseki, Yumi; Kamatani, Naoyuki; Yamanaka, Hisashi

2013-08-01

To validate the association between genetic polymorphisms and gout in Japanese patients, and to investigate the cumulative effects of multiple genetic factors on the development of gout. Subjects were 153 Japanese male patients with gout and 532 male controls. The genotypes of 11 polymorphisms in the 10 genes that have been indicated to be associated with serum uric acid levels or gout were determined. The cumulative effects of the genetic polymorphisms were investigated using a weighted genotype risk score (wGRS) based on the number of risk alleles and the OR for gout. A model to discriminate between patients with gout and controls was constructed by incorporating the wGRS and clinical factors. C statistics method was applied to evaluate the capability of the model to discriminate gout patients from controls. Seven polymorphisms were shown to be associated with gout. The mean wGRS was significantly higher in patients with gout (15.2 ± 2.01) compared to controls (13.4 ± 2.10; p gout. A prediction model for gout that incorporates genetic and clinical factors may be useful for identifying individuals who are at risk of gout.

Sleep and Development in Genetically Tractable Model Organisms.

Science.gov (United States)

Kayser, Matthew S; Biron, David

2016-05-01

Sleep is widely recognized as essential, but without a clear singular function. Inadequate sleep impairs cognition, metabolism, immune function, and many other processes. Work in genetic model systems has greatly expanded our understanding of basic sleep neurobiology as well as introduced new concepts for why we sleep. Among these is an idea with its roots in human work nearly 50 years old: sleep in early life is crucial for normal brain maturation. Nearly all known species that sleep do so more while immature, and this increased sleep coincides with a period of exuberant synaptogenesis and massive neural circuit remodeling. Adequate sleep also appears critical for normal neurodevelopmental progression. This article describes recent findings regarding molecular and circuit mechanisms of sleep, with a focus on development and the insights garnered from models amenable to detailed genetic analyses. Copyright © 2016 by the Genetics Society of America.

Nuclear and radiation techniques - state of art and development trends

International Nuclear Information System (INIS)

Chmielewski, A.G.

1995-01-01

The state of art and development trends of nuclear and radiation techniques in Poland and worldwide have been presented. Among them the radiometric gages, radiation technologies, radiotracer methods and measuring systems for pipeline and vessels, brightness control have been described and their applications in industry, agriculture, health and environment protection have been shown and discussed. 35 refs, 1 fig

Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development

NARCIS (Netherlands)

Pires, Nuno D.; Bemer, Marian; Müller, Lena M.; Baroux, Célia; Spillane, Charles; Grossniklaus, Ueli

2016-01-01

Embryonic development requires a correct balancing of maternal and paternal genetic information. This balance is mediated by genomic imprinting, an epigenetic mechanism that leads to parent-of-origin-dependent gene expression. The parental conflict (or kinship) theory proposes that imprinting can

Genetic opportunities to enhance sustainability of pork production in developing countries: A model for food animals

International Nuclear Information System (INIS)

Forsberg, C.W.; Golovan, S.P.; Ajakaiye, A.; Fan, M.Z.; Hacker, R.R.; Phillips, J.P.; Meidinger, R.G.; Kelly, J.M.

2005-01-01

Currently there is a shortage of food and potable water in many developing countries. Superimposed upon this critical situation, because of the increasing urban wealth in these countries, there is a strong trend of increased consumption of meat, and pork in particular. The consequence of this trend will be increased agricultural pollution, resulting not only from greater use of chemical fertilizer, but also from manure spread on land as fertilizer that may enter freshwater and marine ecosystems causing extensive eutrophication and decreased water quality. The application of transgenic technologies to improve the digestive efficiency and survival of food animals, and simultaneously decreasing their environmental impact is seen as an opportunity to enhance sustainability of animal agriculture without continued capital inputs. Transgenes expressed in pigs that have potential include, for example, genes coding for phytase, lactalbumin and lactoferrin. At the University of Guelph, Escherichia coli phytase has been expressed in the salivary glands of the pig. Selected lines of these pigs utilize plant phytate phosphorus efficiently as a source of phosphorus and excrete faecal material with more than a 60 percent reduction in phosphorus content. Because of their capacity to utilize plant phytate phosphorus and to produce less polluting manure they have a valuable trait that will contribute to enhanced sustainability of pork production in developing countries, where there is less access to either high quality phosphate supplement or phytase enzyme to include in the diet. Issues that require continued consideration as a prelude to the introduction of transgenic animals into developing countries include food and environmental safety, and consumer acceptance of meat products from genetically modified animals. (author)

Conrad Waddington and the Marriage of Genetics, Development ...

Indian Academy of Sciences (India)

genetics of development with the study of evolution. ... bold strokes to bring the two together, but the time was not right and his ideas were pushed ... Often we would discuss bigger biological issues and his insights were often sharp and deep.

Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome.

Science.gov (United States)

Yamaga, Masaya; Takemoto, Minoru; Takada-Watanabe, Aki; Koizumi, Naoko; Kitamoto, Takumi; Sakamoto, Kenichi; Ishikawa, Takahiro; Koshizaka, Masaya; Maezawa, Yoshiro; Yokote, Koutaro

2017-08-01

To determine recent trends in mutation patterns in the WRN gene, which cause Werner syndrome (WS), a rare, inheritable progeroid syndrome in Japan. Retrospective cohort. Longitudinal survey of WS and literature search for case reports. Individuals whose genetic testing their facilities had requested between 2009 and October 2016 (N = 67). A nationwide epidemiological study was conducted from 2009 to 2011 to improve understanding of the pathology of WS and develop therapeutic guidelines. Since 2009, Chiba University Hospital consecutively evaluated the WRN gene in 67 individuals throughout Japan who had requested genetic testing. A literature search was also conducted for case reports on Japanese WS reported since 1997. A definitive diagnosis of WS was confirmed genetically in 50 of 67 participants. Through the literature search, 16 individuals diagnosed genetically with WS were identified. Of these 66 individuals with WS, 42 were homozygous for a WRN mutation, and 21 were compound heterozygotes. One novel mutant allele was identified in an individual with the compound heterozygous genotype. The proportion of compound heterozygotes (31.8%) was significantly greater than reported previously (14.2%), indicating that the incidence of consanguineous marriage of parents has decreased. The increased frequency of individuals with WS with the compound heterozygous genotype is a recent trend in Japan. A long-term follow-up study on WRN homozygotes and compound heterozygotes will allow the relationship between WRN genotype and clinical severity of WS to be evaluated in the future. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

What explains uneven female labor force participation levels and trends in developing countries?

OpenAIRE

Klasen, Stephan

2018-01-01

Rapid fertility decline, a strong expansion of female education, and favorable economic conditions should have promoted female labor force participation in developing countries. Yet trends in female labor force participation (FLFP) have been quite heterogeneous, rising strongly in Latin America, stagnating in many other regions, while improvements were modest in the Middle East and female participation even fell in South Asia. These trends are inconsistent with secular theories such as the Fe...

National genetic improvement programmes in the United States beef ...

African Journals Online (AJOL)

cattle industry is accepting, in fact, demanding estimates of genetic values on yearling bulls. Single and multiple analy ... ordinary event occurred with the formation of the Beef ... assumed genetic trend was non-existent or relatively unimportant ...

Cognitive Development, Genetics Problem Solving, and Genetics Instruction: A Critical Review.

Science.gov (United States)

Smith, Mike U.; Sims, O. Suthern, Jr.

1992-01-01

Review of literature concerning problem solving in genetics and Piagetian stage theory. Authors conclude the research suggests that formal-operational thought is not strictly required for the solution of the majority of classical genetics problems; however, some genetic concepts are difficult for concrete operational students to understand.…

Prenatal and postnatal genetic influence on lung function development

DEFF Research Database (Denmark)

Kreiner-Møller, Eskil; Bisgaard, Hans; Bønnelykke, Klaus

2014-01-01

BACKGROUND: It is unknown to what extent adult lung function genes affect lung function development from birth to childhood. OBJECTIVE: Our aim was to study the association of candidate genetic variants with neonatal lung function and lung function development until age 7 years. METHODS: Lung fun...

Genetic aspects of hypothalamic and pituitary gland development.

Science.gov (United States)

McCabe, Mark J; Dattani, Mehul T

2014-01-01

Hypothalamo-pituitary development during embryogenesis is a highly complex process involving the interaction of a network of spatiotemporally regulated signaling molecules and transcription factors. Mutations in any of the genes encoding these components can lead to congenital hypopituitarism, which is often associated with a wide spectrum of defects affecting craniofacial/midline development. In turn, these defects can be incompatible with life, or lead to disorders encompassing holoprosencephaly (HPE) and cleft palate, and septo-optic dysplasia (SOD). In recent years, there has been increasing evidence of an overlapping genotype between this spectrum of disorders and Kallmann syndrome (KS), defined as the association of hypogonadotropic hypogonadism (HH) and anosmia. This is consistent with the known phenotypic overlap between these disorders and opens a new avenue of identifying novel genetic causes of the hypopituitarism spectrum. This chapter reviews the genetic and molecular events leading to the successful development of the hypothalamo-pituitary axis during embryogenesis, and focuses on genes in which variations/mutations occur, leading to congenital hypopituitarism and associated defects. © 2014 Elsevier B.V. All rights reserved.

Simple sequence repeat marker development and genetic mapping ...

Indian Academy of Sciences (India)

polymorphic SSR (simple sequence repeats) markers from libraries enriched for GA, CAA and AAT repeats, as well as 6 ... ers for quinoa was the development of a genetic linkage map ...... Weber J. L. 1990 Informativeness of human (dC-dA)n.

Trends in the development of equipment for anaerobic fermentation

Energy Technology Data Exchange (ETDEWEB)

Holcak, B; Lutcha, J

1982-01-01

The successful application of anaerobic fermentation to the utilization of diluted wastes for the production of energy stimulated in recent years the development of new types of anaerobic reactors. Although the point of view of a chemical engineer does not encompass the complexity of this microbial process, he still disposes of means that enable him to estimate to what extent is it possible to affect the efficiency of the process by the concept of reactor arrangement. Simulation of behaviour by means of mathematical models enables us to compare quantitatively, for the types of anaerobic reactor under consideration, the apparatuses, and to predict the expected trends in their development.

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

Directory of Open Access Journals (Sweden)

Ortega VE

2015-01-01

Full Text Available Victor E Ortega, Deborah A Meyers, Eugene R Bleecker Center for Genomics and Personalized Medicine Research, Pulmonary Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Human genetics research will be critical to the development of genetic profiles for personalized or precision medicine in asthma. Genetic profiles will consist of gene variants that predict individual disease susceptibility and risk for progression, predict which pharmacologic therapies will result in a maximal therapeutic benefit, and predict whether a therapy will result in an adverse response and should be avoided in a given individual. Pharmacogenetic studies of the glucocorticoid, leukotriene, and β2-adrenergic receptor pathways have focused on candidate genes within these pathways and, in addition to a small number of genome-wide association studies, have identified genetic loci associated with therapeutic responsiveness. This review summarizes these pharmacogenetic discoveries and the future of genetic profiles for personalized medicine in asthma. The benefit of a personalized, tailored approach to health care delivery is needed in the development of expensive biologic drugs directed at a specific biologic pathway. Prior pharmacogenetic discoveries, in combination with additional variants identified in future studies, will form the basis for future genetic profiles for personalized tailored approaches to maximize therapeutic benefit for an individual asthmatic while minimizing the risk for adverse events. Keywords: asthma, pharmacogenetics, response heterogeneity, single nucleotide polymorphism, genome-wide association study

Global trends and priorities for agriculture development in the beginning of the xxi century

Directory of Open Access Journals (Sweden)

Pavel Vasil’evich Smekalov

2011-12-01

Full Text Available This paper pays attention to global issues related to the growth of population and food production: reduced growth rate of agricultural production, reduction of resource potential of agriculture and others. Critical factors and trends of structural changes in agriculture are identified. Results of comparative analysis of the development of farms in European countries and Russia are presented. Studies have shown that at the end of the last century there have been the following trends in the global agriculture: there has been a trend of farm consolidation in size, new controls and control of production are were introduced as well as more stringent quality standards of ecology were launched, which, in turn, require introduction of new technics and technologies; the processes of plants and animals development become more controllable and manageable. Conseptual foresights of pricing in the food market are given. Priority areas of agricultural policy aimed at creating conditions for sustainable rural development and accelerated growth in agricultural production by improving its competitiveness are identified

Current trends in molecular diagnostics of chronic myeloid leukemia.

Science.gov (United States)

Vinhas, Raquel; Cordeiro, Milton; Pedrosa, Pedro; Fernandes, Alexandra R; Baptista, Pedro V

2017-08-01

Nearly 1.5 million people worldwide suffer from chronic myeloid leukemia (CML), characterized by the genetic translocation t(9;22)(q34;q11.2), involving the fusion of the Abelson oncogene (ABL1) with the breakpoint cluster region (BCR) gene. Early onset diagnosis coupled to current therapeutics allow for a treatment success rate of 90, which has focused research on the development of novel diagnostics approaches. In this review, we present a critical perspective on current strategies for CML diagnostics, comparing to gold standard methodologies and with an eye on the future trends on nanotheranostics.

CiteSpace II: Idiom Studies Development Trends

Directory of Open Access Journals (Sweden)

Wenyu Liu Ph.D.

2013-06-01

Full Text Available Idioms, frequently used in daily language, are a typical metaphorical language and may be a cue to uncover the universal language processing mechanism. For the purpose of better mastery of the trends and front of idioms studies, CiteSpace II, an application designed to detect and visualize the development process within a scientific field, is adopted for comprehensive literature review. It is found that (1 idioms studies have thrived since 1990s with American scholars contributing the most, especially those from University of California; (2 suppositions on idiom comprehension mechanism have been inspired by different scholars including Lakoff, Swinney and Gibbs; (3 the exploration of the neurological bases for idiom comprehension has become the pursuit of researchers across different domains.

Genetic analyses for conformation traits in South African Jersey and ...

African Journals Online (AJOL)

JACO

Genetic trends for conformation traits of the South African Holstein show that ... conformation traits can be used to improve stayability, fertility and disease resistance (Rogers et al., 1999; .... Genetic correlations among protein yield, productive.

Development of useful genetic resources by proton-beam irradiation

International Nuclear Information System (INIS)

Kim, In Gyu; Kim, Kug Chan; Park, Hyi Gook; Jung, Il Lae; Seo, Yong Won; Chang, Chul Seong; Kim, Jae Yoon; Ham, Jae Woong

2005-08-01

The aim of this study is to develop new, useful and high-valuable genetic resources through the overproduction of biodegradable plastics and the propagation of wheat using proton-beam irradiation. Useful host strain was isolated through the mutagenization of the Escherichia coli K-12 strain, followed by characterizing the genetic and physiological properties of the E. coli mutant strains. The selected E. coli mutant strain produced above 85g/L of PHB, showed above 99% of PHB intracellular content and spontaneously liberated intracellular PHB granules. Based on the results, the production cost of PHB has been estimated to approximately 2$/kg, leading effective cost-down. Investigated the propagation of wheat and its variation, a selectable criterion of wet pro of was established and genetic analysis of useful mutant was carried out

Emerging Trends in Development of International Information Security Regime

Directory of Open Access Journals (Sweden)

Elena S. Zinovieva

2016-01-01

Full Text Available The article discusses the key trends shaping the international regime on information security. International cooperation in this area at the global level encounters contradictions of state interest. The main actors of the information security are the United States, Russia, China and the EU countries (Britain, France and Germany. The main contradiction is developing between the US on one side and Russia and China on the other. EU countries occupy the middle position, gravitating to that of US. The article proves that international cooperation on information security will reflect the overall logic of the development of international cooperation, which is characterized by a new model of cooperation, with the participation of state and non-state actors, known as multi-stakeholder partnerships and multi-level cooperation. The logic of the formation of an international regime on information security is closest to the logic of the formation of the international non-proliferation regime. It is in the interest of Russia to support the trend towards regionalization of information security regime. Russia can form a regional information security regime in the former Soviet Union on the basis of the CSTO and SCO and potentially on a wider Eurasian space. Such regional regime would give Russia an opportunity to shape the international regime and closely monitor emerging information security issues in the former Soviet Union, and remove the potential threat of "color revolutions".

Current trends in genetic manipulations to enhance abiotic and ...

African Journals Online (AJOL)

Hitherto, tolerant plants were mainly produced by classical breeding techniques. Success in breeding for better adapted varieties to abiotic and biotic stresses depends on the concerted efforts of various research domains including plant and cell physiology, molecular biology, genetics and breeding. However, such process ...

Trends in radioisotope development and utilization in the United States

Energy Technology Data Exchange (ETDEWEB)

Mott, W E [Energy Research and Development Administration, Washington, D.C. (USA)

1976-06-01

The current trends in radioisotope and radiation technology in the United States are overviewed with emphasis on the developments since the 1973 Conference. The comments focus primarily on the research and development activities receiving the most attention today from the various agencies of the Government. Among the many available radionuclides, technetium-99m has played the single most important role for making possible the developments in the field of nuclear medicine. Many other short lived medium-lived nuclides are applied in the fields of nuclear medicine, cardiac pacemaker, artificial heart, and blood irradiator. Radiation processing is now firmly established in the United States. The trends in sewage treatment, polymer-impregnated materials, bioengineering, and food irradiation are reviewed. The programs for californium-252, strontium-90, cesium-137, plutonium-238, and krypton-85 are also reviewed. The author concludes this paper with the acknowledgement that Japanese researchers have contributed to and have been closely involved in many of the programs discussed. Of particular note is the participation in the clinical phase of the californium-252 radiotherapy program. Several Japanese hospitals have been cooperating with the United States since the very beginning of the californium-252 program in determining the value of the californium-252 neutron therapy. The research being performed is unique, and will contribute greatly to the decisions on the ultimate future of californium-252 for therapeutic purposes.

Development of a Streamlined Work Flow for Handling Patients' Genetic Testing Insurance Authorizations.

Science.gov (United States)

Uhlmann, Wendy R; Schwalm, Katie; Raymond, Victoria M

2017-08-01

Obtaining genetic testing insurance authorizations for patients is a complex, time-involved process often requiring genetic counselor (GC) and physician involvement. In an effort to mitigate this complexity and meet the increasing number of genetic testing insurance authorization requests, GCs formed a novel partnership with an industrial engineer (IE) and a patient services associate (PSA) to develop a streamlined work flow. Eight genetics clinics and five specialty clinics at the University of Michigan were surveyed to obtain benchmarking data. Tasks needed for genetic testing insurance authorization were outlined and time-saving work flow changes were introduced including 1) creation of an Excel password-protected shared database between GCs and PSAs, used for initiating insurance authorization requests, tracking and follow-up 2) instituting the PSAs sending GCs a pre-clinic email noting each patients' genetic testing insurance coverage 3) inclusion of test medical necessity documentation in the clinic visit summary note instead of writing a separate insurance letter and 4) PSAs development of a manual with insurance providers and genetic testing laboratories information. These work flow changes made it more efficient to request and track genetic testing insurance authorizations for patients, enhanced GCs and PSAs communication, and reduced tasks done by clinicians.

Current trends in development of explosives in world mining

Energy Technology Data Exchange (ETDEWEB)

Dobnikar, S.

1987-01-01

Surveys development of manufacturing industrial explosives in the 19th and 20th centuries, from first use of black powder, ammonium nitrate and TNT to the use of ANFO, slurries and water gel type explosives. Achievements of explosive producers with worldwide reputation (Ireco Chemicals, Du Pont, Atlas Powder Chemical, Nitro Nobel, Nippon Oil and Fats Co., Thermex Energy Co.) for manufacturing safe, reliable explosives used in surface and underground coal and ore mining (including gassy coal mines) and for quarrying are mentioned. Main characteristics of IREMITE, IREGEL, TOVEX, POURVEX, DRIVEX, Detagel, ANFO (both gel- and emulsion-type), Emulgite and Emulite are presented. A critical opinion about future trends in industrial explosive development is given. 10 refs., 7 tabs.

Genetic and phenotypic parameters of body weight in Zandi sheep

African Journals Online (AJOL)

DR. TONUKARI NYEROVWO

2011-11-02

Nov 2, 2011 ... In the mating season, artificial insemination (AI) was initially performed, but animals ... direct additive genetic effects; m = maternal genetic effects; c = per- .... food intake and performance in the young lamb; although this trend ...

Trends in development of new generation of NPPs with increased safety

International Nuclear Information System (INIS)

Rumyantsev, V.V.

1992-01-01

The main requirements for designing, construction and operation of NPPs with advanced water cooled ALWR and SBWR reactors being under development in the USA are discussed. The trends in modernization of control systems at NPPs of new generation based on wide introduction of digital computers and visualization of technological parameter measurements are considered

The history and development of the Human Genetics Society of Australasia.

Science.gov (United States)

Sutherland, Grant R

2008-08-01

The Human Genetics Society of Australasia is a vibrant professional society with more than 900 members that promotes and regulates the practice of human and medical genetics in Australia and New Zealand. The growth of human genetics was stimulated by the development of diagnostic clinical cytogenetics laboratories in the early to mid 1960s. This coincided with the recognition by medical specialists, mainly pediatricians, that genetic disorders, especially inborn errors of metabolism and birth defects, were of clinical interest and potentially challenging areas for their skills. The organization of professionals in human genetics was slow to evolve. There was an early Western Australian Human Genetics Society, and the cytogenetics community had begun to meet annually from about 1966 but was coordinated by a mailing list rather than as a formal organization. In 1976, as part of the celebrations of the Centenary Year of the Adelaide Children's Hospital, a clinical genetics meeting involving several high profile international speakers and most of the senior medical geneticists in Australia and New Zealand along with the annual meeting of the loose-knit cytogeneticists group agreed that a small working group be charged with setting up a Human Genetics Society. The society was formally incorporated in South Australia in 1977.

Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development.

Science.gov (United States)

Stergiakouli, Evie; Davey Smith, George; Martin, Joanna; Skuse, David H; Viechtbauer, Wolfgang; Ring, Susan M; Ronald, Angelica; Evans, David E; Fisher, Simon E; Thapar, Anita; St Pourcain, Beate

2017-01-01

Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk. Social-communication difficulties ( N  ≤ 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms ( N  ≤ 5678, Strengths and Difficulties Questionnaire, SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data. In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait r g  ≤ 1, p min   =  3 × 10 -4 ) as those between repeated measures of the same trait (within-trait r g  ≤ 0.94, p min   =  7 × 10 -4 ). Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling upregulated genes ( p -meta = 6.4 × 10 -4 ). Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression R 2  = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties

What the Current System Development Trends tell us about Systems Development Methodologies: Toward explaining SSDAM, Agile and IDEF0 Methodologies

Directory of Open Access Journals (Sweden)

Abdulla F. Ally

2015-03-01

Full Text Available Systems integration, customization and component based development approach are of increasing attention. This trend facilitates the research attention to also focus on systems development methodologies. The availability of systems development tools, rapid change in technologies, evolution of mobile computing and the growth of cloud computing have necessitated a move toward systems integration and customization rather than developing systems from scratch. This tendency encourages component based development and discourages traditional systems development approach. The paper presents and evaluates SSADM, IDEF0 and Agile systems development methodologies. More specifically, it examines how they fit or not fit into the current competitive market of systems development. In the view of this perspective, it is anticipated that despite of its popularity, SSADM methodology is becoming obsolete while Agile and IDEF0 methodologies are still gaining acceptance in the current competitive market of systems development. The present study more likely enrich our understanding of the systems development methodologies concepts and draw attention regarding where the current trends in system development are heading.

Precision Medicine and Advancing Genetic Technologies—Disability and Human Rights Perspectives

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Aisling de Paor

2016-08-01

Full Text Available Scientific and technological developments are propelling genetics and genetic technologies into the public sphere. Scientific and technological innovation is becoming more refined, resulting in an increase in the availability and use of genetic testing, and other cutting edge genetic technologies, including gene editing. These genetic advances not only signal a growing trend towards precision medicine, but also provoke consideration of the protection of genetic information as an emerging human rights concern. Particular ethical and legal issues arise from a disability perspective, including the potential for discrimination and privacy violations. In consideration of the intersection of genetics and disability, this article highlights the significant concerns raised as genetic science and technology advances, and the consequences for disability rights, particularly the core concepts of non-discrimination, and respect for diversity and difference. On examining international human rights perspectives, it looks particularly at the UN Convention on the Rights of Persons with Disabilities and how it may be used to guide best practice in this area. With an acknowledgement of historical abuses of genetic science, this article highlights the need to maintain caution as to the potential consequences of advancing genetic technologies on persons with disabilities and indeed on society as a whole.

The genetic consequences of selection in natural populations.

Science.gov (United States)

Thurman, Timothy J; Barrett, Rowan D H

2016-04-01

The selection coefficient, s, quantifies the strength of selection acting on a genetic variant. Despite this parameter's central importance to population genetic models, until recently we have known relatively little about the value of s in natural populations. With the development of molecular genetic techniques in the late 20th century and the sequencing technologies that followed, biologists are now able to identify genetic variants and directly relate them to organismal fitness. We reviewed the literature for published estimates of natural selection acting at the genetic level and found over 3000 estimates of selection coefficients from 79 studies. Selection coefficients were roughly exponentially distributed, suggesting that the impact of selection at the genetic level is generally weak but can occasionally be quite strong. We used both nonparametric statistics and formal random-effects meta-analysis to determine how selection varies across biological and methodological categories. Selection was stronger when measured over shorter timescales, with the mean magnitude of s greatest for studies that measured selection within a single generation. Our analyses found conflicting trends when considering how selection varies with the genetic scale (e.g., SNPs or haplotypes) at which it is measured, suggesting a need for further research. Besides these quantitative conclusions, we highlight key issues in the calculation, interpretation, and reporting of selection coefficients and provide recommendations for future research. © 2016 John Wiley & Sons Ltd.

Transcriptomic analysis, genic SSR development, and genetic diversity of proso millet (Panicum miliaceum; Poaceae).

Science.gov (United States)

Hou, Siyu; Sun, Zhaoxia; Li, Yaoshen; Wang, Yijie; Ling, Hubin; Xing, Guofang; Han, Yuanhuai; Li, Hongying

2017-07-01

Proso millet ( Panicum miliaceum ; Poaceae) is a minor crop with good nutritional qualities and strong tolerance to drought stress and soil infertility. However, studies on genetic diversity have been limited due to a lack of efficient genetic markers. Illumina sequencing technology was used to generate short read sequences of proso millet, and de novo transcriptome assemblies were used to develop a de novo assembly of proso millet. Genic simple sequence repeat (SSR) markers were identified and used to detect polymorphism among 56 accessions. Population structure and genetic similarity coefficient were estimated. In total, 25,341 unique gene sequences and 4724 SSR loci were obtained from the transcriptome, of which 229 pairs of SSR primers were validated, which resulted in 14 polymorphic genic SSR primers exhibiting 43 total alleles. According to the ratio of polymorphic markers (6.1%, 14/229), there are potentially 288 polymorphic genic SSR markers available for genetic assay development in the future. Bayesian population analyses showed that the 56 accessions comprised two distinct groups. A genetic structure and cluster assay indicated that the accessions from the Loess Plateau of China shared a high genetic similarity coefficient with those from other regions and that there was no correlation between genetic diversity and geographic origin. The transcriptome sequencing data and millet-specific SSR markers developed in this study establish an excellent resource for gene discovery and may improve the development of breeding programs in proso millet in the future.

Carbon Capture and Storage Development Trends from a Techno-Paradigm Perspective

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Bobo Zheng

2014-08-01

Full Text Available The world’s energy needs have been continually growing over the past decade, yet fossil fuels are limited. Renewable energies are becoming more prevalent, but are still a long way from being commonplace worldwide. Literature mining is applied to review carbon capture and storage (CCS development trends and to develop and examine a novel carbon capture and storage technological paradigm (CCSTP, which incorporates CCSTP competition, diffusion and shift. This paper first provides an overview of the research and progress in CCS technological development, then applies a techno-paradigm theory to analyze CCSTP development and to provide a guide for future CCS technological trends. CCS could avoid CO2 being released into the atmosphere. Moreover, bioenergy with CCS (BECCS can make a significant contribution to a net removal of anthropogenic CO2 emissions. In this study, we compare the different CCSTP developmental paths and the conventional techno-paradigm by examining the S-curves. The analyses in this paper provide a useful guide for scholars seeking new inspiration in their research and for potential investors who are seeking to invest research funds in more mature technologies. We conclude that political barriers and public acceptance are the major distinctions between the CCSTP and the conventional techno-paradigm. It is expected that policy instruments and economic instruments are going to play a pivotal role in the accomplishment of global carbon reduction scenarios.

New developments in genetics of myositis.

Science.gov (United States)

Rothwell, Simon; Lamb, Janine A; Chinoy, Hector

2016-11-01

This article reviews the advances that have been made in our understanding of the genetics of the idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on polymyositis, dermatomyositis and inclusion body myositis. Two large human leukocyte antigen (HLA) imputation studies have confirmed a strong association with the 8.1 ancestral haplotype in clinical subgroups of myositis and suggest multiple independent associations on this haplotype. Risk in these genes may be due to specific amino acid positions within the peptide-binding grooves of HLA molecules. A large genetic study in 2566 IIM patients revealed associations such as PTPN22, STAT4, UBE2L3 and BLK, which overlap with risk variants reported in other seropositive autoimmune diseases. There is also evidence of different genetic architectures in clinical subgroups of IIM. Candidate gene studies in the Japanese and Chinese populations have replicated previous IIM associations which suggest common aetiology between ethnicities. International collaborations have facilitated large genetic studies in IIM that have revealed much about the genetics of this rare complex disease both within the HLA region and genome-wide. Future approaches, such as sequencing and trans-ethnic meta-analyses, will advance our knowledge of IIM genetics.

Algorithmic Trading with Developmental and Linear Genetic Programming

Science.gov (United States)

Wilson, Garnett; Banzhaf, Wolfgang

A developmental co-evolutionary genetic programming approach (PAM DGP) and a standard linear genetic programming (LGP) stock trading systemare applied to a number of stocks across market sectors. Both GP techniques were found to be robust to market fluctuations and reactive to opportunities associated with stock price rise and fall, with PAMDGP generating notably greater profit in some stock trend scenarios. Both algorithms were very accurate at buying to achieve profit and selling to protect assets, while exhibiting bothmoderate trading activity and the ability to maximize or minimize investment as appropriate. The content of the trading rules produced by both algorithms are also examined in relation to stock price trend scenarios.

Temporal trends in BMI in Argentina by socio-economic position and province-level economic development, 2005-2009.

Science.gov (United States)

Christine, Paul J; Diez Roux, Ana V; Wing, Jeffrey J; Alazraqui, Marcio; Spinelli, Hugo

2015-04-01

We investigated temporal trends in BMI, and assessed hypothesized predictors of trends including socio-economic position (SEP) and province-level economic development, in Argentina. Using multivariable linear regression, we evaluated cross-sectional patterning and temporal trends in BMI and examined heterogeneity in these associations by SEP and province-level economic development with nationally representative samples from Argentina in 2005 and 2009. We calculated mean annual changes in BMI for men and women to assess secular trends. Women, but not men, exhibited a strong cross-sectional inverse association between SEP and BMI, with the lowest-SEP women having an average BMI 2.55 kg/m(2) greater than the highest-SEP women. Analysis of trends revealed a mean annual increase in BMI of 0.19 kg/m(2) and 0.15 kg/m(2) for women and men, respectively, with slightly greater increases occurring in provinces with greater economic growth. No significant heterogeneity in trends existed by individual SEP. BMI is increasing rapidly over time in Argentina irrespective of various sociodemographic characteristics. Higher BMI remains more common in women of lower SEP compared with those of higher SEP.

Trends in the development of unmanned marine technology

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Olejnik Adam

2016-06-01

Full Text Available The article constitutes an attempt to identify current tendencies regarding the development of unmanned marine technologies such as unmanned surface and underwater vehicles. The analyses were performed on the basis of available literature, databases on research projects and internet sources. The material has been divided with regard to the location the research was conducted, the following groups being identified: the European Union, the United States of America and Poland. On the basis of the review of objectives and final effects of projects, tendencies in the development of the discussed marine technology have been identified. An interesting result of the review consists in an observation that Polish R&D works in this area are placed within the main identified developmental trends. Unfortunately, their effects are incomparable due to the minuteness of national funds allocated to R&D as opposed to other countries.

Adoption research, practice, and societal trends: Ten years of progress.

Science.gov (United States)

Wiley, Mary O'Leary

2017-12-01

Adoption involves the legal transfer of parental rights and responsibilities from a child's birth parents to adults who will raise the child (Reitz & Watson, 1992). Research related to adoption has expanded over the past 10 years and has incorporated more focus on implications for practice and public policy. This expansion has reflected increased awareness of the lived experience of adopted individuals, in addition to that of adoptive families and birth or first parents and families, collectively known as the adoption kinship network (Grotevant & McRoy, 1998). Trends discussed included research and social trends or movements (2007-2017) since the publication of the final article in a series of articles in the psychological literature related to adoption in The Counseling Psychologist (Baden & Wiley, 2007; Lee, 2003; O'Brien & Zamostny, 2003; Wiley & Baden, 2005; Zamostny, O'Brien, Baden, & Wiley, 2003; Zamostny, Wiley, O'Brien, Lee, & Baden, 2003). This article summarizes the social trends and research related to adoption over the last 10 years, including longitudinal and meta-analytic studies, increased research and conceptualization of ethnic and racial identity development, research on microaggressions, and research on diverse adoptive families, including those with gay and lesbian parents. Social trends included increased knowledge related to Internet accessibility, genetic information, continued focus on openness, and viewing adoption through a more critical lens. Implications are discussed for the development of programs that enhance competence of mental health professionals and adoption professionals in adoption-competent practice. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Trends of tourism development in Ukraine

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Iryna Skril

2017-10-01

Full Text Available The article is devoted to the actual subject - features development of tourism in Ukraine. Tourism in Ukraine legally declared as a priority of national culture and economy. The promotion of Ukraine as a European state requires the development of tourism industry. The modern concept of leisure activities organization leads to increased demand for tourism in those regions, which have the cultural, social, household identity of the nation, local community. These areas are presented in the most regions of Ukraine. Due to the wealth of historical, cultural, recreational, social and economic resources Ukraine has all essential prerequisites for intensive tourism development. Tourism plays an important role in regional development. Currently, most researches are aimed at economic aspects of development, which are usually associated with external (international tourism. However not enough attention were paid to social and environmental aspects of domestic tourism, which may become an important tool for spiritual revival, patriotic education, formation of ecological thinking and future mentality of the Ukrainian society. In the development of tourism in Ukraine there are some features: changing in the ratio of internal and external tourism in favor of external, a small number of foreign tourists, the gradual reduction in the number of citizens covered by domestic tourism. In 2015 the tourist flow was at the level of 2000 and amounted into 2,02 million people. There was a reduction compared to 2013 by almost 40%. Although the highest rates of reduction (30% occurred in 2014, and 10% - in 2015. So the rate of decrease in tourist flow slowed. The number of foreign tourists significantly reduced to a record 0.75% of the total number of travelers. On the contrary, the number of citizens of Ukraine, which travelled abroad remains very high and exceeds 80%. The number of domestic tourists remains at the level of 17%. Unfortunately, the negative trends in

Trends and developments in computational geometry

NARCIS (Netherlands)

Berg, de M.

1997-01-01

This paper discusses some trends and achievements in computational geometry during the past five years, with emphasis on problems related to computer graphics. Furthermore, a direction of research in computational geometry is discussed that could help in bringing the fields of computational geometry

Developments in statistical analysis in quantitative genetics

DEFF Research Database (Denmark)

Sorensen, Daniel

2009-01-01

of genetic means and variances, models for the analysis of categorical and count data, the statistical genetics of a model postulating that environmental variance is partly under genetic control, and a short discussion of models that incorporate massive genetic marker information. We provide an overview......A remarkable research impetus has taken place in statistical genetics since the last World Conference. This has been stimulated by breakthroughs in molecular genetics, automated data-recording devices and computer-intensive statistical methods. The latter were revolutionized by the bootstrap...... and by Markov chain Monte Carlo (McMC). In this overview a number of specific areas are chosen to illustrate the enormous flexibility that McMC has provided for fitting models and exploring features of data that were previously inaccessible. The selected areas are inferences of the trajectories over time...

Present trends in nuclear energy development

International Nuclear Information System (INIS)

Rotaru, Ioan

2006-01-01

The paper presents the current trends of nuclear energy in Europe, the issue of radioactive waste management, the modern technical solutions for building new nuclear power plants and, also, the nuclear power long term prospects. The following trends and methods of reducing costs are addressed: - upgrading the availability of nuclear power units; since 1990 till now in Europe the availability factor has risen from 74 % to 84%; - extending the operation life of nuclear power plants from 30 - 40 years to 60 years; - stable reduction of the duration of annual planned outages necessary for maintenance and nuclear fuel re-loading; it is noteworthy the performance of Unit 2 Olkiluoto NPP, Finland, that was shutdown for annual outage and fuel re-loading for a 7 days only; - stable cuts of nuclear fuel cost by using advanced nuclear fuel and by increasing the fuel burnup; over the last years, nuclear fuel cost share in the operation costs has constantly decreased to values of about 0.5 USD cent/KWh e; - increase of the rated capacity of the existing in Europe nuclear power units, through upgrading programs that contribute to enhancing their efficiency. In the year 2002 Generation IV International Forum (GIF) finalized the technological strategy in the field, identifying the most promising nuclear power systems for which the research will continue. This strategy also identifies the main objectives that must by pursued within the research-development programs out of which one mentions the following: - identifying sustainable solution for generating electricity; - minimizing the radioactive waste and its management; - optimization of operation costs; - reducing the financial risk comparable to other energy solutions; - excellence in nuclear safety and reliability; - increasing resistance to proliferation; - ruling out the emergency solutions. Finally, the paper mentions the international engagement, representing a new approach in nuclear power, namely the transition to the use

Trends in proliferation: a survey of recent developments

International Nuclear Information System (INIS)

Joshi, Manoj

1995-01-01

It would be a truism to say that the trends in the area of proliferation display positive and negative aspects. On the one hand, the steps being taken by the nuclear haves appear to be designed to maintain their nuclear hegemony forever; on the other, there are indications such as the support being extended to the proposed conventions for the ending of nuclear tests and the production of fissile material for weapons that the nuclear weapons states also realize that the problem cannot be solved unless they also participate in the process and accept non-discriminatory restraints. However, it is much too early to predict which way the situation will develop. (author). 34 refs

Gender Development Research in Sex Roles: Historical Trends and Future Directions

OpenAIRE

Zosuls, Kristina M.; Miller, Cindy Faith; Ruble, Diane N.; Martin, Carol Lynn; Fabes, Richard A.

2011-01-01

The late 1960s through the 1970s marked an important turning point in the field of gender research, including theory and research in gender development. The establishment of Sex Roles in 1975 as a forum for this research represented an important milestone in the field. In this article, we celebrate the 35th anniversary of Sex Roles and, in particular, its contributions to the field of research on children’s and adolescents’ gender development. We examine the trends in research on gender devel...

Impacts of Global Manufacturing Trends on Port Development: The Case of Hong Kong1

Directory of Open Access Journals (Sweden)

Abraham Zhang

2015-03-01

Full Text Available Global manufacturing trends may have profound implications for regional port development. This paper studies Hong Kong port (HKP, which has been one of the world's busiest container ports since the 1990s. In recent years, global manufacturers have started to move away from its primary cargo base, the Chinese Pearl River Delta. This study investigates impacts of the emerging global manufacturing trends on HKP development. It is found that relocation of manufacturing to Western Guangdong benefits HKP, while other relocation destinations make HKP less attractive or even irrelevant. Based on the findings, government policies are discussed that may be formulated to support the growth of the port and wider port-related economy.

Genetic, epigenetic and exogenetic information in development and evolution.

Science.gov (United States)

Griffiths, Paul E

2017-10-06

The idea that development is the expression of information accumulated during evolution and that heredity is the transmission of this information is surprisingly hard to cash out in strict, scientific terms. This paper seeks to do so using the sense of information introduced by Francis Crick in his sequence hypothesis and central dogma of molecular biology. It focuses on Crick's idea of precise determination. This is analysed using an information-theoretic measure of causal specificity. This allows us to reconstruct some of Crick's claims about information in transcription and translation. Crick's approach to information has natural extensions to non-coding regions of DNA, to epigenetic marks, and to the genetic or environmental upstream causes of those epigenetic marks. Epigenetic information cannot be reduced to genetic information. The existence of biological information in epigenetic and exogenetic factors is relevant to evolution as well as to development.

Development of a Laboratory Information Management System for Medical Genetic Investigations (LIMS)

OpenAIRE

Albers, K.

2006-01-01

Studying the genetic factor underlying a set of diseases with modern high- throughput techniques generates huge amounts of data, posing a challenge for data management. In this thesis a database management system called FIDB based on MySQL was developed to handle clinical and experimental genetic data. For the convenience of the users, a web interface was developed to insert, update, delete and display the data. In addition security aspects were taken care of. Currently FIDB is able to organi...

New trends in bioanalytical tools for the detection of genetically modified organisms: an update.

Science.gov (United States)

Michelini, Elisa; Simoni, Patrizia; Cevenini, Luca; Mezzanotte, Laura; Roda, Aldo

2008-10-01

Despite the controversies surrounding genetically modified organisms (GMOs), the production of GM crops is increasing, especially in developing countries. Thanks to new technologies involving genetic engineering and unprecedented access to genomic resources, the next decade will certainly see exponential growth in GMO production. Indeed, EU regulations based on the precautionary principle require any food containing more than 0.9% GM content to be labeled as such. The implementation of these regulations necessitates sampling protocols, the availability of certified reference materials and analytical methodologies that allow the accurate determination of the content of GMOs. In order to qualify for the validation process, a method should fulfil some criteria, defined as "acceptance criteria" by the European Network of GMO Laboratories (ENGL). Several methods have recently been developed for GMO detection and quantitation, mostly based on polymerase chain reaction (PCR) technology. PCR (including its different formats, e.g., double competitive PCR and real-time PCR) remains the technique of choice, thanks to its ability to detect even small amounts of transgenes in raw materials and processed foods. Other approaches relying on DNA detection are based on quartz crystal microbalance piezoelectric biosensors, dry reagent dipstick-type sensors and surface plasmon resonance sensors. The application of visible/near-infrared (vis/NIR) spectroscopy or mass spectrometry combined with chemometrics techniques has also been envisaged as a powerful GMO detection tool. Furthermore, in order to cope with the multiplicity of GMOs released onto the market, the new challenge is the development of routine detection systems for the simultaneous detection of numerous GMOs, including unknown GMOs.

Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968–2007

Science.gov (United States)

Hunter, MJ; Hippman, Catriona; Honer, William G; Austin, Jehannine C.

2014-01-01

Purpose Recent studies have shown that individuals with schizophrenia and their family members are interested in genetic counseling, but few have received this service. We conducted an exploratory, retrospective study to describe (a) the population of individuals who were referred to the provincial program for genetic counseling for a primary indication of schizophrenia, and (b) trends in number of referrals between 1968 and 2007. Methods Referrals for a primary indication of schizophrenia were identified through the provincial program database. Charts were reviewed and the following information was recorded: discipline of referring physician, demographics, psychiatric diagnosis, referred individual’s and partner’s (if applicable) family history, and any current pregnancy history. Data were characterized using descriptive statistics. Results Between 1968 and 2007, 288 referrals were made for a primary indication of schizophrenia. Most referrals were made: (a) for individuals who had a first-degree family member with schizophrenia, rather than for affected individuals, (b) for preconception counseling, and (c) by family physicians (69%), with only 2% by psychiatrists. Conclusions In British Columbia, individuals affected with schizophrenia and their family members are rarely referred for psychiatric genetic counseling. There is a need to identify barriers to psychiatric genetic counseling and develop strategies to improve access. PMID:20034078

Plant Genetic Resources: Selected Issues from Genetic Erosion to Genetic Engineering

Directory of Open Access Journals (Sweden)

Karl Hammer

2008-04-01

Full Text Available Plant Genetic Resources (PGR continue to play an important role in the development of agriculture. The following aspects receive a special consideration:1. Definition. The term was coined in 1970. The genepool concept served as an important tool in the further development. Different approaches are discussed.2. Values of Genetic Resources. A short introduction is highlighting this problem and stressing the economic usfulness of PGR.3. Genetic Erosion. Already observed by E. Baur in 1914, this is now a key issue within PGR. The case studies cited include Ethiopia, Italy, China, S Korea, Greece and S. Africa. Modern approaches concentrate on allelic changes in varieties over time but neglect the landraces. The causes and consequences of genetic erosion are discussed.4. Genetic Resources Conservation. Because of genetic erosion there is a need for conservation. PGR should be consigned to the appropriate method of conservation (ex situ, in situ, on-farm according to the scientific basis of biodiversity (genetic diversity, species diversity, ecosystem diversity and the evolutionary status of plants (cultivated plants, weeds, related wild plants (crop wild relatives.5. GMO. The impact of genetically engineered plants on genetic diversity is discussed.6. The Conclusions and Recommendations stress the importance of PGR. Their conservation and use are urgent necessities for the present development and future survival of mankind.

Secular trends in menarcheal age in India-evidence from the Indian human development survey.

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Praveen Kumar Pathak

Full Text Available Evidence from a number of countries in Europe and North America point towards the secular declining trend in menarcheal age with considerable spatial variations over the past two centuries. Similar trends were reported in several developing countries from Asia, Africa and Latin America. However, data corroborating any secular trend in the menarcheal age of the Indian population remained sparse and inadequately verified.We examined secular trends, regional heterogeneity and association of socioeconomic, anthropometric and contextual factors with menarcheal age among ever-married women (15-49 years in India. Using the pseudo cohort data approach, we fit multiple linear regression models to estimate secular trends in menarcheal age of 91394 ever-married women using the Indian Human Development Survey.The mean age at menarche among Indian women was 13.76 years (95 % CI: 13.75, 13.77 in 2005. It declined by three months from 13.83 years (95% CI: 13.81, 13.85 among women born prior to 1955-1964, to nearly 13.62 years (95% CI: 13.58, 13.67 among women born during late 1985-1989. However, these aggregate national figures mask extensive spatial heterogeneity as mean age at menarche varied from 15.0 years in Himachal Pradesh during 1955-1964 (95% CI: 14.89-15.11 to about 12.1 years in Assam (95% CI: 11.63-12.56 during 1985-1989.The regression analysis established a reduction of nearly one month per decade, suggesting a secular decline in age at menarche among Indian women. Notably, the menarcheal age was significantly associated with the area of residence, geographic region, linguistic groups, educational attainment, wealth status, caste and religious affiliations among Indian women.

Hydrocracking for oriented conversion of heavy oils. Recent trends for catalyst development

Energy Technology Data Exchange (ETDEWEB)

Bertoncini, F.; Bonduelle, A.; Simon, L.J. [IFP Energies nouvelles, Lyon Establishment, Solaize (France). Catalysis and separation Division; Raybaud, P.; Dulot, H. [IFP Energies nouvelles, Lyon Establishment, Solaize (France). Process Desing Modeling Division

2011-07-01

As a result of the global economic crisis since the end of 2008, HCK operators have been looking to increase the profitability of the unit by processing heavier feed streams, including sourer VGO. These feeds present the drawbacks of increased H{sub 2} consumption, lower products yields and quality, and reduction in cycle lengths. Along with optimised process parameters, catalysts manufacturers are also investigating novel formulations to deal with challenging feeds. This lecture briefly summarizes the market trends (fuel demand, refinery's product specification) and the driving forces for HCK catalyst development in order to face these new challenges. Finally, this lecture highlights the innovating trends for HCK catalyst's development. Overview of various ideas developed recently in our research laboratory about (i) rational approaches for the atomic scale design of active phases (morphology, preparation, inhibitor effects), (ii) new preparations of transition metal sulphides for maximising the hydrogenating function (precursors, activation,.), (iii) rational approaches of HCK acidic supports for maximizing the selectivity and (iv) better understanding of HCK reactions. These improvements will be discussed in term of improvement of activity and selectivity of HCK catalyst to cope with future market needs. (orig.)

Development of an event-specific hydrolysis probe quantitative real-time polymerase chain reaction assay for Embrapa 5.1 genetically modified common bean (Phaseolus vulgaris).

Science.gov (United States)

Treml, Diana; Venturelli, Gustavo L; Brod, Fábio C A; Faria, Josias C; Arisi, Ana C M

2014-12-10

A genetically modified (GM) common bean event, namely Embrapa 5.1, resistant to the bean golden mosaic virus (BGMV), was approved for commercialization in Brazil. Brazilian regulation for genetically modified organism (GMO) labeling requires that any food containing more than 1% GMO be labeled. The event-specific polymerase chain reaction (PCR) method has been the primary trend for GMO identification and quantitation because of its high specificity based on the flanking sequence. This work reports the development of an event-specific assay, named FGM, for Embrapa 5.1 detection and quantitation by use of SYBR Green or hydrolysis probe. The FGM assay specificity was tested for Embrapa 2.3 event (a noncommercial GM common bean also resistant to BGMV), 46 non-GM common bean varieties, and other crop species including maize, GM maize, soybean, and GM soybean. The FGM assay showed high specificity to detect the Embrapa 5.1 event. Standard curves for the FGM assay presented a mean efficiency of 95% and a limit of detection (LOD) of 100 genome copies in the presence of background DNA. The primers and probe developed are suitable for the detection and quantitation of Embrapa 5.1.

Mindfulness-based cognitive therapy for depression: trends and developments.

Science.gov (United States)

MacKenzie, Meagan B; Kocovski, Nancy L

2016-01-01

Mindfulness-based cognitive therapy (MBCT) was developed as a psychological intervention for individuals at risk of depressive relapse. Possible mechanisms of change for this intervention are in line with its theoretical underpinnings, and include increases in mindfulness and/or decreases in negative repetitive thoughts. This review provides an overview of current trends in MBCT research, including efficacy and questions regarding the specific effects of MBCT in light of recent comparisons with structurally equivalent control conditions, mechanisms of change, and moderators of treatment outcome. In addition, future directions are discussed, such as challenges with training an adequate number of therapists and disseminating this therapy.

The research status and development trend of stochastic resonance

Science.gov (United States)

Xu, Lei; Peng, Yueping; Liu, Man

2017-12-01

The synergistic reaction under specific conditions of the nonlinear system, weak driving signal and moderate noise can make noise to be advantageous in a certain extent, so as to achieve the purpose of signal enhancement, this seemingly anomalous phenomenon is defined as stochastic resonance. In this paper, the weak signal detection under strong noise background is the main line. The principle of white noise to counteract external noise is expounded, and the present research situation and development trend of stochastic resonance are reviewed in that paper, it also pointed out the direction of further research of stochastic resonance technology.

Comparison of historical bottleneck effects and genetic consequences of re-introduction in a critically endangered island passerine.

Science.gov (United States)

Bristol, Rachel M; Tucker, Rachel; Dawson, Deborah A; Horsburgh, Gavin; Prys-Jones, Robert P; Frantz, Alain C; Krupa, Andy; Shah, Nirmal J; Burke, Terry; Groombridge, Jim J

2013-09-01

Re-introduction is an important tool for recovering endangered species; however, the magnitude of genetic consequences for re-introduced populations remains largely unknown, in particular the relative impacts of historical population bottlenecks compared to those induced by conservation management. We characterize 14 microsatellite loci developed for the Seychelles paradise flycatcher and use them to quantify temporal and spatial measures of genetic variation across a 134-year time frame encompassing a historical bottleneck that reduced the species to ~28 individuals in the 1960s, through the initial stages of recovery and across a second contemporary conservation-introduction-induced bottleneck. We then evaluate the relative impacts of the two bottlenecks, and finally apply our findings to inform broader re-introduction strategy. We find a temporal trend of significant decrease in standard measures of genetic diversity across the historical bottleneck, but only a nonsignificant downward trend in number of alleles across the contemporary bottleneck. However, accounting for the different timescales of the two bottlenecks (~40 historical generations versus introduction. In some cases, the loss of genetic diversity per generation can, initially at least, be greater across re-introduction-induced bottlenecks. © 2013 John Wiley & Sons Ltd.

Systematic review on the conservation genetics of African savannah elephants.

Science.gov (United States)

Zacarias, Daniel; Bini, Luis Mauricio; Loyola, Rafael

2016-01-01

In this paper we review the conservation genetics of African savannah elephants, aiming to understand the spatio-temporal research trends and their underlying factors. As such, we explore three questions associated to the conservation genetics and molecular ecology of these elephants: (1) what are the research trends concerning the conservation genetics of Loxodonta africana ? (2) Do richer countries conduct more research on the genetics of African elephants? (3) Which attributes influence where scholars conduct their research? We examined available peer-reviewed publications from 1993 to 2014 in complementary online databases, including the ISI/Web of Science (WoS), Scopus and Google Scholar (GS), and searched for publications in scientific journals as well as in the reference section of these publications. We analyzed the annual trend of publications in this field of research, including the number of authors, levels of collaboration among authors, year of publication, publishing journal and the countries from where genetic samples were collected. Additionally, we identified main research clusters, authors, and institutional collaborations, based on co-citation and co-occurrence networks. We found that during the study period there was a positive trend in the number of publications and a reduction in the number of authors per paper. Twenty-five countries contributed, with the majority of publications authored by researchers in the USA, Kenya and South Africa. The majority of samples were collected in Kenya, Tanzania and South Africa. Research outputs are associated with the existence of long-term conservation/research projects and research potential as measured by the literacy rate and the number of higher education institutions in a country. Five research clusters were identified, focusing on the origin and evolution of the species, methodological issues and the relatedness among elephant species. Research in this field should be expanded to additional countries

Analysis of the development trend of China’s business administration based on time series

Directory of Open Access Journals (Sweden)

Jiang Rui

2016-01-01

Full Text Available On the general direction of the economic system, China is in a crucial period of the establishment of the modern enterprise system and reform of the macroeconomic system, and a lot of high-quality business administration talents are required to make China’s economy be stably developed. This paper carries out time series analysis of the development situation of China’s business administration major: on the whole, the society currently presents an upward trend on the demand for the business administration talents. With the gradually increasing demand for the business administration talents, various colleges and universities also set up the business administration major to train a large number of administration talents, thus leading to an upward trend for the academic focus on business administration.

WHEAT CHARACTERISTIC DEMAND AND IMPLICATIONS FOR DEVELOPMENT OF GENETICALLY MODIFIED GRAINS

OpenAIRE

Janzen, Edward L.; Mattson, Jeremy W.; Wilson, William W.

2001-01-01

Agricultural biotechnology is advancing rapidly and is embracing all major crops. The adoption of genetically modified corn, soybeans, and cotton have reached high levels in the United States. Wheat is the next major crop confronting the biotechnology issue, but no commercial varieties of genetically modified (GM) wheat have been released yet. Primary opportunities for GM developments in wheat center around improvements that meet consumer and end-user needs/issues in addition to meeting produ...

Recent developments, new trends in seed crushing and oil refining

Directory of Open Access Journals (Sweden)

Kővári Katalin

2004-11-01

Full Text Available Oil processing was considered as slowly changing “traditional” industry but the recent decades’ developments and trends resulted in a lot of changes initiated by market, industry, environment protection and consumer needs. Driving force of the developments were centralization of the industry, more and more concerns on environmental impact, increased importance of food-feed safety, and last but not least research and development activity together with improved analytical capabilities. The presentation gives an overview on the results achieved on the field of the following areas: the criteria of applicability of physical refining of seed oils, solutions for proper degumming, the effect of seed pretreatment and crushing conditions on the crude oil quality, the importance and role of bleaching and active carbon treatment, the proper practice of deacidification/deodorization.

Trend analysis

International Nuclear Information System (INIS)

Smith, M.; Jones, D.R.

1991-01-01

The goal of exploration is to find reserves that will earn an adequate rate of return on the capital invested. Neither exploration nor economics is an exact science. The authors must therefore explore in those trends (plays) that have the highest probability of achieving this goal. Trend analysis is a technique for organizing the available data to make these strategic exploration decisions objectively and is in conformance with their goals and risk attitudes. Trend analysis differs from resource estimation in its purpose. It seeks to determine the probability of economic success for an exploration program, not the ultimate results of the total industry effort. Thus the recent past is assumed to be the best estimate of the exploration probabilities for the near future. This information is combined with economic forecasts. The computer software tools necessary for trend analysis are (1) Information data base - requirements and sources. (2) Data conditioning program - assignment to trends, correction of errors, and conversion into usable form. (3) Statistical processing program - calculation of probability of success and discovery size probability distribution. (4) Analytical processing - Monte Carlo simulation to develop the probability distribution of the economic return/investment ratio for a trend. Limited capital (short-run) effects are analyzed using the Gambler's Ruin concept in the Monte Carlo simulation and by a short-cut method. Multiple trend analysis is concerned with comparing and ranking trends, allocating funds among acceptable trends, and characterizing program risk by using risk profiles. In summary, trend analysis is a reality check for long-range exploration planning

A Belated Green Revolution for Cannabis: Virtual Genetic Resources to Fast-Track Cultivar Development.

Science.gov (United States)

Welling, Matthew T; Shapter, Tim; Rose, Terry J; Liu, Lei; Stanger, Rhia; King, Graham J

2016-01-01

Cannabis is a predominantly diecious phenotypically diverse domesticated genus with few if any extant natural populations. International narcotics conventions and associated legislation have constrained the establishment, characterization, and use of Cannabis genetic resource collections. This has resulted in the underutilization of genepool variability in cultivar development and has limited the inclusion of secondary genepools associated with genetic improvement strategies of the Green Revolution. The structured screening of ex situ germplasm and the exploitation of locally-adapted intraspecific traits is expected to facilitate the genetic improvement of Cannabis. However, limited attempts have been made to establish the full extent of genetic resources available for pre-breeding. We present a thorough critical review of Cannabis ex situ genetic resources, and discuss recommendations for conservation, pre-breeding characterization, and genetic analysis that will underpin future cultivar development. We consider East Asian germplasm to be a priority for conservation based on the prolonged historical cultivation of Cannabis in this region over a range of latitudes, along with the apparent high levels of genetic diversity and relatively low representation in published genetic resource collections. Seed cryopreservation could improve conservation by reducing hybridization and genetic drift that may occur during Cannabis germplasm regeneration. Given the unique legal status of Cannabis, we propose the establishment of a global virtual core collection based on the collation of consistent and comprehensive provenance meta-data and the adoption of high-throughput DNA sequencing technologies. This would enable representative core collections to be used for systematic phenotyping, and so underpin breeding strategies for the genetic improvement of Cannabis.

TianShuiShi space breeding current situation and developing trend

International Nuclear Information System (INIS)

Wang Fuquan; Song Jianrong; Zhang Zhongping; Guo Zhenfang

2011-01-01

TianShuiShi is located in xian to lanzhou among two big cities, the five space launch, has vegetables, food, grasses, flowers, rape, melon and fruit, Chinese traditional medicine, amount of 8 categories of crops, such as the 22 new material after carrying the ground breeding work. Only vegetables on identified 23 aerospace new varieties. After ten years of space breeding, summarizes the present situation of TianShuiShi space breeding, development experience, characteristic, trends, and puts forward the development space breeding TianShuiShi organization and breeding of talent from the matching policy and grow up incentive mechanism, strengthen the cooperation and all over the country, establishing fiscal policy support from the aspects such as advice. (authors)

Trends and Perspectives of Social and Economic Development of the Perm region

Directory of Open Access Journals (Sweden)

Taliya Kh. Usmanova

2017-01-01

Full Text Available Purpose: the main purpose of the article is study the current prerequisites and trends of the economic development of the Perm Region to formulate proposals and recommendations within the framework of the program for the long-term development of regional social and economic systems. The main hypothesis of the article is that the social and economic development of the Perm Region requires the creation of innovative ways to develop promising areas of business based on relevant trends and assumptions.Methods: the methodology of solving the tasks is based on the use of the method of dialectical research, methods of economic analysis, forecasting, situational and system analysis, expert assessments and analysis of empirical data.Results: the results of the work are to study the economic processes in the region, including indicators and indicators of the region's social and economic development, and further develop recommendations and proposals for the development of priority areas in project management and selection of optimal project planning models to ensure sustainable development of the region and its competitiveness.Conclusions and Relevance: priority goals for solving the current economic problems of the Perm Region are to increase the income of the population and increase the revenue of the regional budget. To increase the pace and ensure the stability of economic growth, increase the real income of citizens, achieve technological leadership, a consistent solution to a number of specific tasks is necessary. It is important that the implementation of economic policy should be based on building partnerships between public authorities and entrepreneurship, aimed at increasing the efficiency of companies and the development of the economy of the region.

Male Reproductive Disorders and Fertility Trends

DEFF Research Database (Denmark)

Skakkebaek, Niels E; Rajpert-De Meyts, Ewa; Buck Louis, Germaine M

2016-01-01

than genetics, are the most important factors in the observed trends. These environmental factors might act either directly or via epigenetic mechanisms. In the latter case, the effects of exposures might have an impact for several generations post-exposure. In conclusion, there is an urgent need...... evidence suggests that it most often is related to environmental exposures of the fetal testis. However, environmental factors can also affect the adult endocrine system. Based on our review of genetic and environmental factors, we conclude that environmental exposures arising from modern lifestyle, rather...... to prioritize research in reproductive physiology and pathophysiology, particularly in highly industrialized countries facing decreasing populations. We highlight a number of topics that need attention by researchers in human physiology, pathophysiology, environmental health sciences, and demography....

Energy sector assistance in developing countries: Current trends and policy recommendations

International Nuclear Information System (INIS)

Tharakan, Pradeep J.; Castro, Julio de; Kroeger, Timm

2007-01-01

An estimated 2.5 billion people remain without access to modern energy supplies. This shortfall is expected to grow as the population in developing countries continues to grow rapidly and the existing infrastructure ages. The United Nations' goal of lowering poverty by half by 2015 will not be attained unless the poor in developing countries gain greater access to basic infrastructure and services, including energy services. The key objective of this paper is to analyze trends in overseas development assistance (ODA) to the energy sector in developing countries during the period 1990-2003, relative to realized private sector investments. This analysis then forms the basis for policy recommendations for consideration by decision makers within countries that are major contributors to ODA

[Sporulation or competence development? A genetic regulatory network model of cell-fate determination in Bacillus subtilis].

Science.gov (United States)

Lu, Zhenghui; Zhou, Yuling; Zhang, Xiaozhou; Zhang, Guimin

2015-11-01

Bacillus subtilis is a generally recognized as safe (GRAS) strain that has been widely used in industries including fodder, food, and biological control. In addition, B. subtilis expression system also plays a significant role in the production of industrial enzymes. However, its application is limited by its low sporulation frequency and transformation efficiency. Immense studies have been done on interpreting the molecular mechanisms of sporulation and competence development, whereas only few of them were focused on improving sporulation frequency and transformation efficiency of B. subtilis by genetic modification. The main challenge is that sporulation and competence development, as the two major developmental events in the stationary phase of B. subtilis, are regulated by the complicated intracellular genetic regulatory systems. In addition, mutual regulatory mechanisms also exist in these two developmental events. With the development of genetic and metabolic engineering, constructing genetic regulatory networks is currently one of the most attractive research fields, together with the genetic information of cell growth, metabolism, and development, to guide the industrial application. In this review, the mechanisms of sporulation and competence development of B. subtilis, their interactions, and the genetic regulation of cell growth were interpreted. In addition, the roles of these regulatory networks in guiding basic and applied research of B. subtilis and its related species were discussed.

Search for major genes with progeny test data to accelerate the development of genetically superior loblolly pine

Energy Technology Data Exchange (ETDEWEB)

NCSU

2003-12-30

This research project is to develop a novel approach that fully utilized the current breeding materials and genetic test information available from the NCSU-Industry Cooperative Tree Improvement Program to identify major genes that are segregating for growth and disease resistance in loblolly pine. If major genes can be identified in the existing breeding population, they can be utilized directly in the conventional loblolly pine breeding program. With the putative genotypes of parents identified, tree breeders can make effective decisions on management of breeding populations and operational deployment of genetically superior trees. Forest productivity will be significantly enhanced if genetically superior genotypes with major genes for economically important traits could be deployed in an operational plantation program. The overall objective of the project is to develop genetic model and analytical methods for major gene detection with progeny test data and accelerate the development of genetically superior loblolly pine. Specifically, there are three main tasks: (1) Develop genetic models for major gene detection and implement statistical methods and develop computer software for screening progeny test data; (2) Confirm major gene segregation with molecular markers; and (3) Develop strategies for using major genes for tree breeding.

Modern Trends in the Development of Business Technologies in Entrepreneurship

Directory of Open Access Journals (Sweden)

Dudko Pavlo M.

2017-09-01

Full Text Available The aim of the article is to study modern trends in the development of business technologies and their integration into entrepreneurship. Business technologies are a combination of methods, techniques, innovations, technical and mental solutions that promote development of business, expand its capabilities and create new prospects for it. The main business technologies that are widely used in entrepreneurship and have gained worldwide recognition include franchising, leasing, outsourcing, cashback, clustering. Due to the rapid development of information technologies and the Internet, such business technologies as e-commerce, IT outsourcing, offshore programming, crowdsourcing and the CRM strategy have emerged. At the same time, business technologies develop independently and without using modern technical innovations, an example of which is co-marketing. Summarizing, it can be noted that business technologies are not only the existing methods of business development but also a constant and dynamic search for new solutions in entrepreneurship. The development and improvement of the existing business technologies, as well as the emergence of new ones, directly depends on the technological progress and development of mankind.

Key Trends and Problems of Regional Innovation Systems' Development in Poland and Ukraine

OpenAIRE

Oleksandr Fedirko

2014-01-01

This article is devoted to comparative study of regional innovation development in Poland and Ukraine. Innovation potential and performance of Ukrainian regions assessment is grounded on the regional innovation systems approach, employing selected indicators of the EU regional innovation evaluation criteria. Key trends and problematic issues of regional innovation development are captured through a number of methods: comparative analysis, calculating variation of regional innovation capacity ...

Food and Health Some Current Issues and Future Trends

OpenAIRE

Gormley, T. R. (Thomas Ronan)

1991-01-01

This paper deals with some of the many current issues and future trends in the area of food, diet and health in Europe. A complete coverage would be impossible in a short article in view of the extent and complexity of the food system and its major interaction with health. It is also important to stress at the outset that food/diet is only one component of health and other factors such as environment, overall lifestyle and genetics also play a major role. The genetic dimension is of particula...

Ancestry and dental development: A geographic and genetic perspective

NARCIS (Netherlands)

B. Dhamo (Brunilda); L. Kragt (Lea); Grgic, O. (Olja); S. Vucic (Strahinja); M.C. Medina-Gomez (Carolina); Rivadeneira, F. (Fernando); V.W.V. Jaddoe (Vincent); E.B. Wolvius (Eppo); E.M. Ongkosuwito (Edwin)

2017-01-01

textabstractObjective: In this study, we investigated the influence of ancestry on dental development in the Generation R Study. Methods: Information on geographic ancestry was available in 3,600 children (1,810 boys and 1,790 girls, mean age 9.81±0.35 years) and information about genetic ancestry

[Landscape classification: research progress and development trend].

Science.gov (United States)

Liang, Fa-Chao; Liu, Li-Ming

2011-06-01

Landscape classification is the basis of the researches on landscape structure, process, and function, and also, the prerequisite for landscape evaluation, planning, protection, and management, directly affecting the precision and practicability of landscape research. This paper reviewed the research progress on the landscape classification system, theory, and methodology, and summarized the key problems and deficiencies of current researches. Some major landscape classification systems, e. g. , LANMAP and MUFIC, were introduced and discussed. It was suggested that a qualitative and quantitative comprehensive classification based on the ideology of functional structure shape and on the integral consideration of landscape classification utility, landscape function, landscape structure, physiogeographical factors, and human disturbance intensity should be the major research directions in the future. The integration of mapping, 3S technology, quantitative mathematics modeling, computer artificial intelligence, and professional knowledge to enhance the precision of landscape classification would be the key issues and the development trend in the researches of landscape classification.

New trends and developments in radiation chemistry

International Nuclear Information System (INIS)

1989-10-01

Radiation chemistry is a branch of chemistry that studies chemical transformations in materials exposed to high-energy radiations. It uses radiation as the initiator of chemical reactions. Practical applications of radiation chemistry today extend to many fields, including health care, food and agriculture, manufacturing, industrial pollution abatement, biotechnology and telecommunications. The important advantage of radiation chemistry lies in its ability to be used to produce, and study, almost any reactive atomic and molecular species playing a part in chemical reactions, synthesis, industrial processes, or in biological systems. The techniques are applicable to gaseous, liquid, solid, and heterogeneous systems. By combining different techniques of radiation chemistry with analytical chemistry, the reaction mechanism and kinetics of chemical reactions are studied. In November 1988 in Bologna, Italy, the IAEA convened an advisory group meeting to assess new trends and developments in radiation chemistry. The present publication includes most of the contributions presented at the meeting. Refs, figs and tabs

A Brief Analysis of Development Situations and Trend of Cloud Computing

Science.gov (United States)

Yang, Wenyan

2017-12-01

in recent years, the rapid development of Internet technology has radically changed people's work, learning and lifestyles. More and more activities are completed by virtue of computers and networks. The amount of information and data generated is bigger day by day, and people rely more on computer, which makes computing power of computer fail to meet demands of accuracy and rapidity from people. The cloud computing technology has experienced fast development, which is widely applied in the computer industry as a result of advantages of high precision, fast computing and easy usage. Moreover, it has become a focus in information research at present. In this paper, the development situations and trend of cloud computing shall be analyzed and researched.

Transcriptomic analysis, genic SSR development, and genetic diversity of proso millet (Panicum miliaceum; Poaceae)1

Science.gov (United States)

Hou, Siyu; Sun, Zhaoxia; Li, Yaoshen; Wang, Yijie; Ling, Hubin; Xing, Guofang; Han, Yuanhuai; Li, Hongying

2017-01-01

Premise of the study: Proso millet (Panicum miliaceum; Poaceae) is a minor crop with good nutritional qualities and strong tolerance to drought stress and soil infertility. However, studies on genetic diversity have been limited due to a lack of efficient genetic markers. Methods: Illumina sequencing technology was used to generate short read sequences of proso millet, and de novo transcriptome assemblies were used to develop a de novo assembly of proso millet. Genic simple sequence repeat (SSR) markers were identified and used to detect polymorphism among 56 accessions. Population structure and genetic similarity coefficient were estimated. Results: In total, 25,341 unique gene sequences and 4724 SSR loci were obtained from the transcriptome, of which 229 pairs of SSR primers were validated, which resulted in 14 polymorphic genic SSR primers exhibiting 43 total alleles. According to the ratio of polymorphic markers (6.1%, 14/229), there are potentially 288 polymorphic genic SSR markers available for genetic assay development in the future. Bayesian population analyses showed that the 56 accessions comprised two distinct groups. Discussion: A genetic structure and cluster assay indicated that the accessions from the Loess Plateau of China shared a high genetic similarity coefficient with those from other regions and that there was no correlation between genetic diversity and geographic origin. The transcriptome sequencing data and millet-specific SSR markers developed in this study establish an excellent resource for gene discovery and may improve the development of breeding programs in proso millet in the future. PMID:28791202

Functional and Genetic Analysis of Choroid Plexus Development in Zebrafish

Directory of Open Access Journals (Sweden)

Hannah Elizabeth Henson

2014-11-01

Full Text Available The choroid plexus, an epithelial-based structure localized in the brain ventricle, is the major component of the blood-cerebrospinal fluid barrier. The choroid plexus produces the cerebrospinal fluid and regulates the components of the cerebrospinal fluid. Abnormal choroid plexus function is associated with neurodegenerative diseases, tumor formation in the choroid plexus epithelium, and hydrocephaly. In this study, we used zebrafish (Danio rerio as a model system to understand the genetic components of choroid plexus development. We generated an enhancer trap line, Et(cp:EGFPsj2, that expresses enhanced green fluorescent protein (EGFP in the choroid plexus epithelium. Using immunohistochemistry and fluorescent tracers, we demonstrated that the zebrafish choroid plexus possesses brain barrier properties such as tight junctions and transporter activity. Thus, we have established zebrafish as a functionally relevant model to study choroid plexus development. Using an unbiased approach, we performed a forward genetic dissection of the choroid plexus to identify genes essential for its formation and function. Using Et(cp:EGFPsj2, we isolated 10 recessive mutant lines with choroid plexus abnormalities, which were grouped into five classes based on GFP intensity, epithelial localization, and overall choroid plexus morphology. We also mapped the mutation for two mutant lines to chromosomes 4 and 21, respectively. The mutants generated in this study can be used to elucidate specific genes and signaling pathways essential for choroid plexus development, function, and/or maintenance and will provide important insights into how these genetic mutations contribute to disease.

Genetic effects

International Nuclear Information System (INIS)

Kato, Hiroo

1975-01-01

In 1948-1953 a large scale field survey was conducted to investigate the possible genetic effects of A-bomb radiation on over 70,000 pregnancy terminations in the cities of Hiroshima and Nagasaki. The indices of possible genetic effect including sex ratio, birth weight, frequency of malformation, stillbirth, neonatal death, deaths within 9 months and anthropometric measurements at 9 months of age for these children were investigated in relation to their parent's exposure status to the A-bomb. There were no detectable genetic effects in this sample, except for a slight change in sex ratio which was in the direction to be expected if exposure had induced sex-linked lethal mutations. However, continued study of the sex ratio, based upon birth certificates in Hiroshima and Nagasaki for 1954-1962, did not confirm the earlier trend. Mortality in these children of A-bomb survivors is being followed using a cohort of 54,000 subjects. No clearly significant effect of parental exposure on survival of the children has been demonstrated up to 1972 (age 17 on the average). On the basis of the regression data, the minimal genetic doubling dose of this type of radiation for mutations resulting in death is estimated at 46 rem for the father and 125 rem for the mother. (auth.)

Understanding the development trends of low-carbon energy technologies: A patent analysis

International Nuclear Information System (INIS)

Albino, Vito; Ardito, Lorenzo; Dangelico, Rosa Maria; Messeni Petruzzelli, Antonio

2014-01-01

Highlights: • Governments’ strategies set important frameworks to develop and sustain low-carbon energy technologies. • Commercial activities play a key role in the low-carbon energy technologies’ development. • The number of patents that are based upon basic research is growing. - Abstract: Eco-innovations are being recognized as fundamental means to foster sustainable development, as well as to create new business opportunities. Nowadays, the eco-innovation concept is gaining ground within both academic and practitioner studies with the attempt to better understand the main dynamics underlying its nature and guide policymakers and companies in supporting its development. This paper contributes to the extant literature on eco-innovation by providing a comprehensive overview of the evolution of a specific type of eco-innovations that are playing a crucial role in the current socio-economic agenda, namely low-carbon energy technologies. Accordingly, we focus our attention on the related patenting activity of different countries and organizations over time, as well as on influencing policy initiatives and events. Hence, we collected 131,661 patents granted at the United States Patent and Trademark Office (U.S.PTO.) between 1971 and 2010, and belonging to the “Nuclear power generation”, “Alternative energy production”, and “Energy conservation” technological classes, as indicated by the International Patent Classification (IPC) Green Inventory. Our findings report the development trends of low-carbon energy technologies, as well as identify major related environmental programs, historical events, and private sector initiatives explaining those trends, hence revealing how these different circumstances have significantly influenced their development over time

Hydropower development trends from a technological paradigm perspective

International Nuclear Information System (INIS)

Xu, Jiuping; Ni, Ting; Zheng, Bobo

2015-01-01

Highlights: • We propose a novel concept of hydropower development technological paradigm. • We create a data analysis system to visualize the keyword foci. • Future trajectories include hybrid power systems and resources from seawater. • The HDTP consists of a three-stage evolution and a policy framework. • The HDTP provides a how-to-do solution for the soft path. - Abstract: Hydropower has long been considered the backbone of the power generation sector in low-carbon and sustainable energy systems. Yet, as reliance on hydropower has been generally declining, the world is awakening to the need to fundamentally rethink the way hydropower is developed and managed. The paper proposes a systematic methodology to research the development trends and find a more sustainable hydropower path. Literature mining using the data analysis system and the technological paradigm theory were adopted to conduct the research. The keyword visualization results were found to meet the laws for the three phases of the technological paradigm. Specific key areas, such as small hydropower plants, hybrid power systems, and hydropower from seawater were identified as past, present and near future trajectories. To further accelerate hydropower development, specific subsidies and incentives need to be provided in areas such as capital costs and technological support. The study paves the way for a soft path solution which complements the hard path in hydropower field

Melanoma genetics and the development of rational therapeutics.

Science.gov (United States)

Chudnovsky, Yakov; Khavari, Paul A; Adams, Amy E

2005-04-01

Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.

Development of Ayurveda - Tradition to trend.

Science.gov (United States)

Mukherjee, Pulok K; Harwansh, Ranjit K; Bahadur, Shiv; Banerjee, Subhadip; Kar, Amit; Chanda, Joydeb; Biswas, Sayan; Ahmmed, Sk Milan; Katiyar, C K

2017-02-02

Ayurveda entails a scientific tradition of harmonious living and its origin can be traced from ancient knowledge in Rigveda and Atharvaveda. Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several Ayurvedic medicines have been exploiting for treatment and management of various diseases in human beings. The several drugs have been developed and practiced from Ayurveda since ancient time to modern practice as 'tradition to trend'. The potential of Ayurvedic medicine needs to be explored further with modern scientific validation approaches for better therapeutic leads. The present study was aimed to explore the various aspects of Ayurveda and inspired drug discovery approaches for its promotion and development. We have reviewed all the literature related to the history and application of Ayurvedic herbs. Various aspects for the quality control, standardization, chemo-profiling, and metabolite fingerprinting for quality evaluation of Ayurvedic drugs. The development of Ayurvedic drugs is gaining momentum with the perspectives of safety, efficacy and quality for promotion and management of human health. Scientific documentation, process validation and several others significant parameters are key points, which can ensure the quality, safety and effectiveness of Ayurvedic drugs. The present review highlights on the major goal of Ayurveda and their significant role in healthcare system. Ayurveda deals with several classical formulations including arka, asavas, aristas, churna, taila, vati, gutika, bhasma etc. There are several lead molecules that have been developed from the Ayurvedic herbs, which have various significant therapeutic activities. Chemo-profiling of Ayurvedic drug is essential in order to assess the quality of products. It deals with bioactive compound quantification, spurious and allied drug determination, chromatographic fingerprinting, standardization, stability and quality consistency of Ayurvedic products. Scientific

Genetic influences on thinning of the cerebral cortex during development

NARCIS (Netherlands)

van Soelen, I.L.C.; Brouwer, R.M.; van Baal, G.C.M.; Schnack, H.G.; Peper, J.S.; Collins, D.L.; Evans, A.C.; Kahn, R.S.; Boomsma, D.I.; Hulshoff Pol, H.E.

2012-01-01

During development from childhood to adulthood the human brain undergoes considerable thinning of the cerebral cortex. Whether developmental cortical thinning is influenced by genes and if independent genetic factors influence different parts of the cortex is not known. Magnetic resonance brain

Development Trends in the Fields of Education and Care for Vulnerable Groups in Slovenia

Science.gov (United States)

Kobolt, Alenka; Pavel, Jana Rapus

2010-01-01

This paper presents the main developments in education and care for vulnerable groups of children and youth in Slovenia over the past twenty years. It describes the education system and provides an overview of the development of social pedagogy as a discipline and the practice of working with some groups of vulnerable young people. The trends can…

A toolkit for incorporating genetics into mainstream medical services: Learning from service development pilots in England.

Science.gov (United States)

Bennett, Catherine L; Burke, Sarah E; Burton, Hilary; Farndon, Peter A

2010-05-14

As advances in genetics are becoming increasingly relevant to mainstream healthcare, a major challenge is to ensure that these are integrated appropriately into mainstream medical services. In 2003, the Department of Health for England announced the availability of start-up funding for ten 'Mainstreaming Genetics' pilot services to develop models to achieve this. Multiple methods were used to explore the pilots' experiences of incorporating genetics which might inform the development of new services in the future. A workshop with project staff, an email questionnaire, interviews and a thematic analysis of pilot final reports were carried out. Seven themes relating to the integration of genetics into mainstream medical services were identified: planning services to incorporate genetics; the involvement of genetics departments; the establishment of roles incorporating genetic activities; identifying and involving stakeholders; the challenges of working across specialty boundaries; working with multiple healthcare organisations; and the importance of cultural awareness of genetic conditions. Pilots found that the planning phase often included the need to raise awareness of genetic conditions and services and that early consideration of organisational issues such as clinic location was essential. The formal involvement of genetics departments was crucial to success; benefits included provision of clinical and educational support for staff in new roles. Recruitment and retention for new roles outside usual career pathways sometimes proved difficult. Differences in specialties' working practices and working with multiple healthcare organisations also brought challenges such as the 'genetic approach' of working with families, incompatible record systems and different approaches to health professionals' autonomous practice. 'Practice points' have been collated into a Toolkit which includes resources from the pilots, including job descriptions and clinical tools. These can

Incorporating latitudinal and central–marginal trends in assessing genetic variation across species ranges

Science.gov (United States)

Qinfeng Guo

2012-01-01

The genetic variation across a species’ range is an important factor in speciation and conservation, yet searching for general patterns and underlying causes remains challenging. While the majority of comparisons between central and marginal populations have revealed a general central–marginal (C-M) decline in genetic diversity, others show no clear pattern. Similarly...

Development trends for diagnostic systems in nuclear power plants

International Nuclear Information System (INIS)

Kunze, U.; Pohl, U.

1998-01-01

Monitoring systems used in nuclear power plants have made remarkable progress over the past four or five years. Development has followed the trends and changes in philosophy for the purpose of monitoring systems in nuclear power plants: They are no longer expected to fulfill only safety tasks, the plant personnel require information on which to base condition-oriented maintenance. A new generation of monitoring and diagnostic systems has been developed by Siemens recently. This new generation, called Series '95, is PC-based. An overview is given for the KUeS '95 loose parts diagnostic system, the SUeS '95 vibration monitoring system, the FLUeS leak detection system and the SIPLUG valve diagnostics system. The objectives behind the development of these new systems are both safety-related and economic. The new systems improve the reliability and quality of monitoring techniques and incorporate better detection and diagnostic capabilities. Progress has also been made in automation of the systems so as to reduce routine work, give higher sensitivity for the monitoring task and reduce the scope of maintenance. (author)

On recent advances in human engineering Provocative trends in embryology, genetics, and regenerative medicine.

Science.gov (United States)

Anton, Roman

2016-01-01

Advances in embryology, genetics, and regenerative medicine regularly attract attention from scientists, scholars, journalists, and policymakers, yet implications of these advances may be broader than commonly supposed. Laboratories culturing human embryos, editing human genes, and creating human-animal chimeras have been working along lines that are now becoming intertwined. Embryogenic methods are weaving traditional in vivo and in vitro distinctions into a new "in vivitro" (in life in glass) fabric. These and other methods known to be in use or thought to be in development promise soon to bring society to startling choices and discomfiting predicaments, all in a global effort to supply reliably rejuvenating stem cells, to grow immunologically non-provocative replacement organs, and to prevent, treat, cure, or even someday eradicate diseases having genetic or epigenetic mechanisms. With humanity's human-engineering era now begun, procedural prohibitions, funding restrictions, institutional controls, and transparency rules are proving ineffective, and business incentives are migrating into the most basic life-sciences inquiries, wherein lie huge biomedical potentials and bioethical risks. Rights, health, and heritage are coming into play with bioethical presumptions and formal protections urgently needing reassessment.

Genetic mapping of variation in dauer larvae development in growing populations of Caenorhabditis elegans

NARCIS (Netherlands)

Green, J.W.M.; Snoek, L.B.; Kammenga, J.E.; Harvey, S.C.

2013-01-01

In the nematode Caenorhabditis elegans, the appropriate induction of dauer larvae development within growing populations is likely to be a primary determinant of genotypic fitness. The underlying genetic architecture of natural genetic variation in dauer formation has, however, not been thoroughly

Incorporating genetic sampling in long-term monitoring and adaptive management in the San Diego County Management Strategic Plan Area, Southern California

Science.gov (United States)

Vandergast, Amy G.

2017-06-02

Habitat and species conservation plans usually rely on monitoring to assess progress towards conservation goals. Southern California, USA, is a hotspot of biodiversity and home to many federally endangered and threatened species. Here, several regional multi-species conservation plans have been implemented to balance development and conservation goals, including in San Diego County. In the San Diego County Management Strategic Plan Area (MSPA), a monitoring framework for the preserve system has been developed with a focus on species monitoring, vegetation monitoring, threats monitoring and abiotic monitoring. Genetic sampling over time (genetic monitoring) has proven useful in gathering species presence and abundance data and detecting population trends, particularly related to species and threats monitoring objectives. This report reviews genetic concepts and techniques of genetics that relate to monitoring goals and outlines components of a genetic monitoring scheme that could be applied in San Diego or in other monitoring frameworks throughout the Nation.

Integration of genetic and demographic data to assess population risk in a continuously distributed species

Science.gov (United States)

Fedy, Bradley C.; Row, Jeffery R.; Oyler-McCance, Sara J.

2017-01-01

The identification and demographic assessment of biologically meaningful populations is fundamental to species’ ecology and management. Although genetic tools are used frequently to identify populations, studies often do not incorporate demographic data to understand their respective population trends. We used genetic data to define subpopulations in a continuously distributed species. We assessed demographic independence and variation in population trends across the distribution. Additionally, we identified potential barriers to gene flow among subpopulations. We sampled greater sage-grouse (Centrocercus urophasianus) leks from across their range (≈175,000 Km2) in Wyoming and amplified DNA at 14 microsatellite loci for 1761 samples. Subsequently, we assessed population structure in unrelated individuals (n = 872) by integrating results from multiple Bayesian clustering approaches and used the boundaries to inform our assessment of long-term population trends and lek activity over the period of 1995–2013. We identified four genetic clusters of which two northern ones showed demographic independence from the others. Trends in population size for the northwest subpopulation were statistically different from the other three genetic clusters and the northeast and southwest subpopulations demonstrated a general trend of increasing proportion of inactive leks over time. Population change from 1996 to 2012 suggested population growth in the southern subpopulations and decline, or neutral, change in the northern subpopulations. We suggest that sage-grouse subpopulations in northern Wyoming are at greater risk of extirpation than the southern subpopulations due to smaller census and effective population sizes and higher variability within subpopulations. Our research is an example of incorporating genetic and demographic data and provides guidance on the identification of subpopulations of conservation concern.

Urban partnerships in low-carbon development: Opportunities and challenges of an emerging trend in global climate politics

Directory of Open Access Journals (Sweden)

Jan Beermann

2014-05-01

Full Text Available This study explores the linkages between two recent trends in global climate governance. The first trend is the growing focus on cities in the multi-level governance of climate change. Whereas international climate change negotiations often end in deadlock, many urban centers across the world are taking the lead. Industrialized cities from the Global North and increasingly cities from the emerging Southern economies are experimenting with innovative and ambitious programs to reduce their local carbon footprints. A second trend is the expan¬ding urban North-South cooperation in the area of low-carbon development. This cooperation takes various forms, such as city twinning, transnational municipal networks and trans-local development cooperation. A key target of these initiatives is to develop joint projects and exchange knowledge to foster low-carbon development pathways. This study analyzes the conditions of success and failure in selected Indo-German urban low-carbon partnerships with a particular focus on institutional arrangements. The paper presents evidence from three initiatives and argues that successful trans-local cooperation depends largely on the interplay between institutional forms and the development of social capital. Building on these findings, the paper discusses what lessons may be drawn from the emergence of urban North-South cooperation for the future development of global climate governance.

Reverse Genetics Approaches for the Development of Influenza Vaccines

Science.gov (United States)

Nogales, Aitor; Martínez-Sobrido, Luis

2016-01-01

Influenza viruses cause annual seasonal epidemics and occasional pandemics of human respiratory disease. Influenza virus infections represent a serious public health and economic problem, which are most effectively prevented through vaccination. However, influenza viruses undergo continual antigenic variation, which requires either the annual reformulation of seasonal influenza vaccines or the rapid generation of vaccines against potential pandemic virus strains. The segmented nature of influenza virus allows for the reassortment between two or more viruses within a co-infected cell, and this characteristic has also been harnessed in the laboratory to generate reassortant viruses for their use as either inactivated or live-attenuated influenza vaccines. With the implementation of plasmid-based reverse genetics techniques, it is now possible to engineer recombinant influenza viruses entirely from full-length complementary DNA copies of the viral genome by transfection of susceptible cells. These reverse genetics systems have provided investigators with novel and powerful approaches to answer important questions about the biology of influenza viruses, including the function of viral proteins, their interaction with cellular host factors and the mechanisms of influenza virus transmission and pathogenesis. In addition, reverse genetics techniques have allowed the generation of recombinant influenza viruses, providing a powerful technology to develop both inactivated and live-attenuated influenza vaccines. In this review, we will summarize the current knowledge of state-of-the-art, plasmid-based, influenza reverse genetics approaches and their implementation to provide rapid, convenient, safe and more effective influenza inactivated or live-attenuated vaccines. PMID:28025504

Some trends and perspectives on globalization, economic growth, equality, and development

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Giuseppe Ammendola

2011-01-01

Full Text Available The world economy is more complex than it has ever been. This paper looks at some frameworks used for description, analysis, and prediction in the three areas of economic growth, equality, and development, while also highlighting some important past and current trends. The selection of frameworks and trends represents clearly a necessarily brief and subjective choice of the author on the basis of his perception of their “usefulness” for purposes of public and private decision-making.The paper starts by discussing how economic growth is impacting the classification of the economies of the world. It then looks at how countries’ economies can be viewed in terms of ease of doing business, of adaptability to openness and change, and of types of capitalism adopted. In the second section, issues of economic inequality within and between the countries of the world and their citizens are examined. In the third section, the paper looks at development. It starts by briefly discussing the merits of going beyond GDP and of looking at the Human Development Index (HDI in order to try to measure other forms of progress, such as in health and education. The paper then traces the evolution of development economics and the advice given to policy makers in developing countries, and also examines the role of institutions in development and the controversies surrounding foreign aid. It concludes by looking briefly at additional dimensions of human development such as empowerment and sustainability.The picture that emerges is one of a world in which decision-makers have to make use in a combined way of a plurality of disciplines to understand the realities confronting them and to design and implement good policies. In so doing, they have to confront the challenges of appropriate sequencing, must very often choose second-best options, and have to make clever use of the lessons learned from countries with very different geographical, political, economic, social

GENETIC CHANGES FOR PERFORMANCE TRAITS IN SLOVENIAN PIG NUCLEUS HERDS

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Špela Malovrh

2000-06-01

Full Text Available In Slovenian pig nucleus herds, the genetic trends for performance traits in boars were investigated using mixed model methodology. Altogether, data sets from four farms with test stations consisted of 60709 records for five breeds: Swedish Landrace (SL, Large White (LW, Duroc (D, Pietrain (P, and German Landrace (GL boars from years 1975 to 1999. Separate analyses were performed for each farm using the PEST package. Breed, season, and weight on test within breed were fixed effects, while common litter environment and additive genetic effect were treated as random. Genetic trends for days on test from 30 to 100 kg (DoT30100, feed conversion efficiency from 30 to 100 kg (FCE30100, and ultrasonically measured backfat thickness (BF100 were expressed as linear regression of the averages of predicted breeding values on the year of birth. Estimates for genetic changes varied between farms and breeds from +0.0046 to –0.374 day, +0.0019 to – 0.013, and +0.262 to –0.221 mm per year for DoT30100, FCE30100, and BF100, respectively.

Genetic modification and genetic determinism

Science.gov (United States)

Resnik, David B; Vorhaus, Daniel B

2006-01-01

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions. PMID:16800884

Genetic modification and genetic determinism

Directory of Open Access Journals (Sweden)

Vorhaus Daniel B

2006-06-01

Full Text Available Abstract In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions.

Development Trends And Economic Assessment Of The Integration Processes On The Metals Market

OpenAIRE

Romanova, Olga A.; Makarov, Eduard V.

2018-01-01

The article examines the integration process from the perspective of three dimensions, which characterize the increase in quantity and appearance of new relationships; strength, character and stability of emerging communications; dynamics and the proper form of the process. The authors identify the development trends of the integration processes in the metals market and provide justification for the breaking of the period of Russian metal trading for 1991–2016 into five stages of development....

Calving interval genetic parameters and trends for dairy breeds in ...

African Journals Online (AJOL)

Calving interval (CI) is a fertility trait that can be used in selection programmes to minimize the negative effects that selection for production have on fertility. CI can be derived from milk recording data, therefore this fertility trait can easily be implemented in the National Dairy Genetic Evaluations of South Africa. The aim of this ...

Genetic Parameters and Trends of Somatic Cell Score and Udder ...

African Journals Online (AJOL)

Dube

mastitis resistance in view of its medium to high genetic correlation with and its ... Selection in South African Holstein cattle has been mostly on milk yield, ... Lactations less than 150 days and greater than 305 days were also not included as they are ... X – indicates factor included; HYSC – herd, year, season of classification, ...

Systematic review on the conservation genetics of African savannah elephants

Directory of Open Access Journals (Sweden)

Daniel Zacarias

2016-10-01

Full Text Available Background In this paper we review the conservation genetics of African savannah elephants, aiming to understand the spatio-temporal research trends and their underlying factors. As such, we explore three questions associated to the conservation genetics and molecular ecology of these elephants: (1 what are the research trends concerning the conservation genetics of Loxodonta africana? (2 Do richer countries conduct more research on the genetics of African elephants? (3 Which attributes influence where scholars conduct their research? Materials and Methods We examined available peer-reviewed publications from 1993 to 2014 in complementary online databases, including the ISI/Web of Science (WoS, Scopus and Google Scholar (GS, and searched for publications in scientific journals as well as in the reference section of these publications. We analyzed the annual trend of publications in this field of research, including the number of authors, levels of collaboration among authors, year of publication, publishing journal and the countries from where genetic samples were collected. Additionally, we identified main research clusters, authors, and institutional collaborations, based on co-citation and co-occurrence networks. Results We found that during the study period there was a positive trend in the number of publications and a reduction in the number of authors per paper. Twenty-five countries contributed, with the majority of publications authored by researchers in the USA, Kenya and South Africa. The majority of samples were collected in Kenya, Tanzania and South Africa. Research outputs are associated with the existence of long-term conservation/research projects and research potential as measured by the literacy rate and the number of higher education institutions in a country. Five research clusters were identified, focusing on the origin and evolution of the species, methodological issues and the relatedness among elephant species. Conclusions

Global Trends and Development Prospects for Oil and the Oil Products Market

Directory of Open Access Journals (Sweden)

Maria Dorozhkina

2006-03-01

Full Text Available This article discusses the important issue of the development of the global market of oil and oil products. It offers an overview of how this market was formed and its current status, classification, location and potential of countries in the oil and oil processing business. It analyzes the Ukrainian oil products market. The article discusses the shortcomings and strategic areas for the development of Ukraine’s oil transport system. It presents an optimum method for creating integration groups in order to develop the oil processing business in Ukraine for the future. The article considers the main trends and outlines development prospects for the global oil and oil products market.

Contemporary Development Trends in Administrative-Legal Relations in the System of Administrative Justice

Science.gov (United States)

Abdikerimova, Aynur A.

2016-01-01

The purpose of the study is to determine the main contemporary development trends in administrative-legal relations in the field of administrative justice. In order to examine theoretical and practical issues of modern administrative justice, normative legal acts identifying the relations in the system of administrative justice in the Republic in…

Development and evaluation of multi-agent models predicting Twitter trends in multiple domains

NARCIS (Netherlands)

Attema, T.; Maanen, P.P. van; Meeuwissen, E.

2015-01-01

This paper concerns multi-agent models predicting Twitter trends. We use a step-wise approach to develop a novel agent-based model with the following properties: (1) it uses individual behavior parameters for a set of Twitter users and (2) it uses a retweet graph to model the underlying social

Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries.

Science.gov (United States)

Grant, William B

2014-01-01

Alzheimer's disease (AD) rates in Japan and developing countries have risen rapidly in recent years. Researchers have associated factors such as the Western diet, obesity, alcohol consumption, and smoking with risk of AD. This paper evaluates whether the dietary transition might explain the rising trend of AD prevalence in Japan and in developing countries, evaluating other factors when possible. This study used two approaches to see whether dietary or other changes could explain AD trends in Japan and developing countries. One approach involved comparing trends of AD in Japan with changes in national dietary supply factors, alcohol consumption, and lung cancer mortality rates from zero to 25 years before the prevalence data. The second compared AD prevalence values for eight developing countries with dietary supply factors from zero to 25 years before the prevalence data. For Japan, alcohol consumption, animal product, meat and rice supply, and lung cancer rates correlated highly with AD prevalence data, with the strongest correlation for a lag of 15-25 years. In the eight-country study, total energy and animal fat correlated highly with AD prevalence data, with a lag of 15-20 years. Mechanisms to explain the findings include increased obesity for the eight countries, and increases in cholesterol, saturated fat, and iron from increases in animal products and meat supply for Japan. Evidently AD rates will continue rising in non-Western countries for some time unless we address major risk factors involving diet, obesity, and smoking.

Application of Wilmink’s Exponential Function in Genetic Analysis of 305-d Milk Production and Lactation Persistency in Holstein Cows of Razavi Khorasan

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R Izadkhah

2012-02-01

Full Text Available To estimate heritability and genetic trend for 305-d milk production and lactation persistency, a total of 130,668 monthly test day milk yields belonging to 15,183 first lactation Holstein cows in 131 herds and calved from 2000 to 2009 were used. To calculate 305-d milk yield as well as lactation persistency, estimated parameters of Wilmink’s exponential function were applied. The parameters of the function were estimated by SAS software. Genetic and environmental variance components and heritability of the traits were estimated by single trait animal model using DMU software. Genetic trend was estimated based upon weighted simple linear regression of average breeding values on calving year. Heritability estimate of 305-d milk yield and lactation persistency were found to be 0.184 and 0.05, respectively. A positive significant phenotypic trend (166.11 kg per year was observed for 305-d milk yield while a non-significant genetic trend (-2.0107 was revealed for the trait. For the lactation persistency, there were no significant phenotypic (0.054 % per year and genetic (0.003 % per year trends over the period of time.

Genetic Regulation of Pituitary Gland Development in Human and Mouse

OpenAIRE

Kelberman, Daniel; Rizzoti, Karine; Lovell-Badge, Robin; Robinson, Iain C. A. F.; Dattani, Mehul T.

2009-01-01

Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s pouch. These factors dictate organ commitment, cell differentiation, and cell proliferation within the anterior pituitary. Abnormalities in these processes are associated with congenital hypopituitarism, a spectrum of disorders that includes syndr...

Digital library research : current developments and trends

OpenAIRE

Shiri, Ali

2003-01-01

This column gives an overview of current trends in digital library research under the following headings: digital library architecture, systems, tools and technologies; digital content and collections; metadata; interoperability; standards; knowledge organisation systems; users and usability; legal, organisational, economic, and social issues in digital libraries.

Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017.

Science.gov (United States)

Olugasa, Babasola O; Odigie, Eugene A; Lawani, Mike; Ojo, Johnson F

2015-01-01

The objective was to develop a case-pattern model for Lassa fever (LF) among humans and derive predictors of time-trend point distribution of LF cases in Liberia in view of the prevailing under-reporting and public health challenge posed by the disease in the country. A retrospective 5 years data of LF distribution countrywide among humans were used to train a time-trend model of the disease in Liberia. A time-trend quadratic model was selected due to its goodness-of-fit (R2 = 0.89, and P Liberia, on which a predictive model was developed. We proposed a computationally feasible two-stage space-time permutation approach to estimate the time-trend parameters and conduct predictive inference on LF in Liberia.

A toolkit for incorporating genetics into mainstream medical services: Learning from service development pilots in England

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Burton Hilary

2010-05-01

Full Text Available Abstract Background As advances in genetics are becoming increasingly relevant to mainstream healthcare, a major challenge is to ensure that these are integrated appropriately into mainstream medical services. In 2003, the Department of Health for England announced the availability of start-up funding for ten 'Mainstreaming Genetics' pilot services to develop models to achieve this. Methods Multiple methods were used to explore the pilots' experiences of incorporating genetics which might inform the development of new services in the future. A workshop with project staff, an email questionnaire, interviews and a thematic analysis of pilot final reports were carried out. Results Seven themes relating to the integration of genetics into mainstream medical services were identified: planning services to incorporate genetics; the involvement of genetics departments; the establishment of roles incorporating genetic activities; identifying and involving stakeholders; the challenges of working across specialty boundaries; working with multiple healthcare organisations; and the importance of cultural awareness of genetic conditions. Pilots found that the planning phase often included the need to raise awareness of genetic conditions and services and that early consideration of organisational issues such as clinic location was essential. The formal involvement of genetics departments was crucial to success; benefits included provision of clinical and educational support for staff in new roles. Recruitment and retention for new roles outside usual career pathways sometimes proved difficult. Differences in specialties' working practices and working with multiple healthcare organisations also brought challenges such as the 'genetic approach' of working with families, incompatible record systems and different approaches to health professionals' autonomous practice. 'Practice points' have been collated into a Toolkit which includes resources from the pilots

Genetic regulation of pituitary gland development in human and mouse.

Science.gov (United States)

Kelberman, Daniel; Rizzoti, Karine; Lovell-Badge, Robin; Robinson, Iain C A F; Dattani, Mehul T

2009-12-01

Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke's pouch. These factors dictate organ commitment, cell differentiation, and cell proliferation within the anterior pituitary. Abnormalities in these processes are associated with congenital hypopituitarism, a spectrum of disorders that includes syndromic disorders such as septo-optic dysplasia, combined pituitary hormone deficiencies, and isolated hormone deficiencies, of which the commonest is GH deficiency. The highly variable clinical phenotypes can now in part be explained due to research performed over the last 20 yr, based mainly on naturally occurring and transgenic animal models. Mutations in genes encoding both signaling molecules and transcription factors have been implicated in the etiology of hypopituitarism, with or without other syndromic features, in mice and humans. To date, mutations in known genes account for a small proportion of cases of hypopituitarism in humans. However, these mutations have led to a greater understanding of the genetic interactions that lead to normal pituitary development. This review attempts to describe the complexity of pituitary development in the rodent, with particular emphasis on those factors that, when mutated, are associated with hypopituitarism in humans.

Genetically Modified (GM) Foods and Ethical Eating.

Science.gov (United States)

Dizon, Francis; Costa, Sarah; Rock, Cheryl; Harris, Amanda; Husk, Cierra; Mei, Jenny

2016-02-01

The ability to manipulate and customize the genetic code of living organisms has brought forth the production of genetically modified organisms (GMOs) and consumption of genetically modified (GM) foods. The potential for GM foods to improve the efficiency of food production, increase customer satisfaction, and provide potential health benefits has contributed to the rapid incorporation of GM foods into the American diet. However, GM foods and GMOs are also a topic of ethical debate. The use of GM foods and GM technology is surrounded by ethical concerns and situational judgment, and should ideally adhere to the ethical standards placed upon food and nutrition professionals, such as: beneficence, nonmaleficence, justice and autonomy. The future of GM foods involves many aspects and trends, including enhanced nutritional value in foods, strict labeling laws, and potential beneficial economic conditions in developing nations. This paper briefly reviews the origin and background of GM foods, while delving thoroughly into 3 areas: (1) GMO labeling, (2) ethical concerns, and (3) health and industry applications. This paper also examines the relationship between the various applications of GM foods and their corresponding ethical issues. Ethical concerns were evaluated in the context of the code of ethics developed by the Academy of Nutrition and Dietetics (AND) that govern the work of food and nutrition professionals. Overall, there is a need to stay vigilant about the many ethical implications of producing and consuming GM foods and GMOs. © 2015 Institute of Food Technologists®

Genetic Algorithms for Development of New Financial Products

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Eder Oliveira Abensur

2007-06-01

Full Text Available New Product Development (NPD is recognized as a fundamental activity that has a relevant impact on the performance of companies. Despite the relevance of the financial market there is a lack of work on new financial product development. The aim of this research is to propose the use of Genetic Algorithms (GA as an alternative procedure for evaluating the most favorable combination of variables for the product launch. The paper focuses on: (i determining the essential variables of the financial product studied (investment fund; (ii determining how to evaluate the success of a new investment fund launch and (iii how GA can be applied to the financial product development problem. The proposed framework was tested using 4 years of real data from the Brazilian financial market and the results suggest that this is an innovative development methodology and useful for designing complex financial products with many attributes.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Science.gov (United States)

Pulley, Jill M; Shirey-Rice, Jana K; Lavieri, Robert R; Jerome, Rebecca N; Zaleski, Nicole M; Aronoff, David M; Bastarache, Lisa; Niu, Xinnan; Holroyd, Kenneth J; Roden, Dan M; Skaar, Eric P; Niswender, Colleen M; Marnett, Lawrence J; Lindsley, Craig W; Ekstrom, Leeland B; Bentley, Alan R; Bernard, Gordon R; Hong, Charles C; Denny, Joshua C

2017-04-01

The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains. The Incubator supports a diverse pipeline of drug indication finding projects, leveraging the natural experiment of human genetics.

The Genetics of Biofuel Traits in Panicum Grasses: Developing a Model System with Diploid Panicum Hallii

Energy Technology Data Exchange (ETDEWEB)

Juenger, Thomas [Univ. of Texas, Austin, TX (United States). Dept. of Integrative Biology; Wolfrum, Ed [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-07-31

Our DOE funded project focused on characterizing natural variation in C4 perennial grasses including switchgrass (Panicum virgatum) and Hall’s panicgrass (Panicum hallii). The main theme of our project was to better understand traits linked with plant performance and that impact the utility of plant biomass as a biofuel feedstock. In addition, our project developed tools and resources for studying genetic variation in Panicum hallii. Our project successfully screened both Panicum virgatum and Panicum hallii diverse natural collections for a host of phenotypes, developed genetic mapping populations for both species, completed genetic mapping for biofuel related traits, and helped in the development of genomic resources of Panicum hallii. Together, these studies have improved our understanding of the role of genetic and environmental factors in impacting plant performance. This information, along with new tools, will help foster the improvement of perennial grasses for feedstock applications.

[Reverse genetics system of rotaviruses: development and application for analysis of VP4 spike protein].

Science.gov (United States)

Komoto, Satoshi

2013-01-01

The rotavirus genome is composed of 11 gene segments of double-stranded (ds)RNA. Reverse genetics is the powerful and ideal methodology for the molecular analysis of virus biology, which enables the virus genome to be artificially manipulated. Although reverse genetics systems exist for nearly all major groups of RNA viruses, development of such a system for rotaviruses is more challenging owing in part to the technical complexity of manipulation of their multi-segmented genome. A breakthrough in the field of rotavirus reverse genetics came in 2006, when we established the first reverse genetics system for rotaviruses, which is a partially plasmid-based system that permits replacement of a viral gene segment with the aid of a helper virus. Although this helper virus-driven system is technically limited and gives low levels of recombinant viruses, it allows alteration of the rotavirus genome, thus contributing to our understanding of these medically important viruses. In this review, I describe the development and application of our rotavirus reverse genetics system, and its future perspectives.

DEVELOPMENT TRENDS IN THE GLOBAL DENTAL MARKET

Directory of Open Access Journals (Sweden)

Veronica BULAT

2013-12-01

Full Text Available The paper analyses the key trends of the market, and segments the global dental equipment and consumables market by components and into various geographic regions in way of market size. It discusses the key market drivers, main players, restraints and opportunities of the global dental equipment and consumables market.

[The role of the genetics history in genetics teaching].

Science.gov (United States)

Li, Ming-Hui

2006-08-01

The research of the scientific history and development status reflect the science and technology level of a nation. The genetic history is one of the branches of the life science and the 21st century is life science century. The genetics history in the teaching of genetics not only can help students get familiar with the birth and development of genetics, but also enhance their thinking ability and scientific qualities. The roles and approaches of teaching are discussed in this paper.

Alternatives to animal testing: research, trends, validation, regulatory acceptance.

Science.gov (United States)

Huggins, Jane

2003-01-01

Current trends and issues in the development of alternatives to the use of animals in biomedical experimentation are discussed in this position paper. Eight topics are considered and include refinement of acute toxicity assays; eye corrosion/irritation alternatives; skin corrosion/irritation alternatives; contact sensitization alternatives; developmental/reproductive testing alternatives; genetic engineering (transgenic) assays; toxicogenomics; and validation of alternative methods. The discussion of refinement of acute toxicity assays is focused primarily on developments with regard to reduction of the number of animals used in the LD(50) assay. However, the substitution of humane endpoints such as clinical signs of toxicity for lethality in these assays is also evaluated. Alternative assays for eye corrosion/irritation as well as those for skin corrosion/irritation are described with particular attention paid to the outcomes, both successful and unsuccessful, of several validation efforts. Alternative assays for contact sensitization and developmental/reproductive toxicity are presented as examples of methods designed for the examination of interactions between toxins and somewhat more complex physiological systems. Moreover, genetic engineering and toxicogenomics are discussed with an eye toward the future of biological experimentation in general. The implications of gene manipulation for research animals, specifically, are also examined. Finally, validation methods are investigated as to their effectiveness, or lack thereof, and suggestions for their standardization and improvement, as well as implementation are reviewed.

Recent developments in computer modeling add ecological realism to landscape genetics

Science.gov (United States)

Background / Question / Methods A factor limiting the rate of progress in landscape genetics has been the shortage of spatial models capable of linking life history attributes such as dispersal behavior to complex dynamic landscape features. The recent development of new models...

Genetic algorithms

Science.gov (United States)

Wang, Lui; Bayer, Steven E.

1991-01-01

Genetic algorithms are mathematical, highly parallel, adaptive search procedures (i.e., problem solving methods) based loosely on the processes of natural genetics and Darwinian survival of the fittest. Basic genetic algorithms concepts are introduced, genetic algorithm applications are introduced, and results are presented from a project to develop a software tool that will enable the widespread use of genetic algorithm technology.

Fast reactors in Russia: State of the art and trends of development

International Nuclear Information System (INIS)

Poplavsky, V.M.; Ashurko, Yu.M.; Zverev, K.V.; Oshkanov, N.N.; Korol'kov, A.S.; Filin, A.I.

2002-01-01

This status report contains the following: facts on nuclear power in Russia from 2001-2002; plans for further development of nuclear power; state of the art on operation of fast reactors in 2002, namely BN-600, experimental reactors BOR-60 and BR-10; construction of NPP BN-800; participation in activities on BN-350 reactor decommissioning; description of trends of design studies in the field of fast reactors and accelerator driven systems

Development of the carapacial ridge: implications for the evolution of genetic networks in turtle shell development.

Science.gov (United States)

Moustakas, Jacqueline E

2008-01-01

Paleontologists and neontologists have long looked to development to understand the homologies of the dermal bones that form the "armor" of turtles, crocodiles, armadillos, and other vertebrates. This study shows molecular evidence supporting a dermomyotomal identity for the mesenchyme of the turtle carapacial ridge. The mesenchyme of the carapace primordium expresses Pax3, Twist1, Dermo1, En1, Sim1, and Gremlin at early stages and before overt ossification expresses Pax1. A hypothesis is proposed that this mesenchyme forms dermal bone in the turtle carapace. A comparison of regulatory gene expression in the primordia of the turtle carapace, the vertebrate limb, and the vertebral column implies the exaptation of key genetic networks in the development of the turtle shell. This work establishes a new role for this mesodermal compartment and highlights the importance of changes in genetic regulation in the evolution of morphology.

Genetic secrets: Protecting privacy and confidentiality in the genetic era

Energy Technology Data Exchange (ETDEWEB)

Rothstein, M.A. [ed.

1998-07-01

Few developments are likely to affect human beings more profoundly in the long run than the discoveries resulting from advances in modern genetics. Although the developments in genetic technology promise to provide many additional benefits, their application to genetic screening poses ethical, social, and legal questions, many of which are rooted in issues of privacy and confidentiality. The ethical, practical, and legal ramifications of these and related questions are explored in depth. The broad range of topics includes: the privacy and confidentiality of genetic information; the challenges to privacy and confidentiality that may be projected to result from the emerging genetic technologies; the role of informed consent in protecting the confidentiality of genetic information in the clinical setting; the potential uses of genetic information by third parties; the implications of changes in the health care delivery system for privacy and confidentiality; relevant national and international developments in public policies, professional standards, and laws; recommendations; and the identification of research needs.

Googling trends in conservation biology.

Science.gov (United States)

Proulx, Raphaël; Massicotte, Philippe; Pépino, Marc

2014-02-01

Web-crawling approaches, that is, automated programs data mining the internet to obtain information about a particular process, have recently been proposed for monitoring early signs of ecosystem degradation or for establishing crop calendars. However, lack of a clear conceptual and methodological framework has prevented the development of such approaches within the field of conservation biology. Our objective was to illustrate how Google Trends, a freely accessible web-crawling engine, can be used to track changes in timing of biological processes, spatial distribution of invasive species, and level of public awareness about key conservation issues. Google Trends returns the number of internet searches that were made for a keyword in a given region of the world over a defined period. Using data retrieved online for 13 countries, we exemplify how Google Trends can be used to study the timing of biological processes, such as the seasonal recurrence of pollen release or mosquito outbreaks across a latitudinal gradient. We mapped the spatial extent of results from Google Trends for 5 invasive species in the United States and found geographic patterns in invasions that are consistent with their coarse-grained distribution at state levels. From 2004 through 2012, Google Trends showed that the level of public interest and awareness about conservation issues related to ecosystem services, biodiversity, and climate change increased, decreased, and followed both trends, respectively. Finally, to further the development of research approaches at the interface of conservation biology, collective knowledge, and environmental management, we developed an algorithm that allows the rapid retrieval of Google Trends data. © 2013 Society for Conservation Biology.

Cutaneous drug hypersensitivity : Immunological and genetic perspective

Directory of Open Access Journals (Sweden)

Kisalay Ghosh

2011-01-01

Full Text Available Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.

Faculty Development for Advancing Community Engagement in Higher Education: Current Trends and Future Directions

Science.gov (United States)

Welch, Marshall; Plaxton-Moore, Star

2017-01-01

This research involved the conduct of a conceptual review of 28 refereed journal articles and a survey of campus centers for community engagement staff to identify salient features and trends of existing faculty development programming designed to advance service-learning and community engagement in higher education. Results of this investigation…

Determinants of Virulence and In Vitro Development Colocalize on a Genetic Map of Setosphaeria turcica.

Science.gov (United States)

Mideros, Santiago X; Chung, Chia-Lin; Wiesner-Hanks, Tyr; Poland, Jesse A; Wu, Dongliang; Fialko, Ariel A; Turgeon, B Gillian; Nelson, Rebecca J

2018-02-01

Generating effective and stable strategies for resistance breeding requires an understanding of the genetics of host-pathogen interactions and the implications for pathogen dynamics and evolution. Setosphaeria turcica causes northern leaf blight (NLB), an important disease of maize for which major resistance genes have been deployed. Little is known about the evolutionary dynamics of avirulence (AVR) genes in S. turcica. To test the hypothesis that there is a genetic association between avirulence and in vitro development traits, we (i) created a genetic map of S. turcica, (ii) located candidate AVRHt1 and AVRHt2 regions, and (iii) identified genetic regions associated with several in vitro development traits. A cross was generated between a race 1 and a race 23N strain, and 221 progeny were isolated. Genotyping by sequencing was used to score 2,078 single-nucleotide polymorphism markers. A genetic map spanning 1,981 centimorgans was constructed, consisting of 21 linkage groups. Genetic mapping extended prior evidence for the location and identity of the AVRHt1 gene and identified a region of interest for AVRHt2. The genetic location of AVRHt2 colocalized with loci influencing radial growth and mycelial abundance. Our data suggest a trade-off between virulence on Ht1 and Ht2 and the pathogen's vegetative growth rate. In addition, in-depth analysis of the genotypic data suggests the presence of significant duplication in the genome of S. turcica.

Trends in scenario development methodologies and integration in NUMO's approach

International Nuclear Information System (INIS)

Ebashi, Takeshi; Ishiguro, Katsuhiko; Wakasugi, Keiichiro; Kawamura, Hideki; Gaus, Irina; Vomvoris, Stratis; Martin, Andrew J.; Smith, Paul

2011-01-01

The development of scenarios for quantitative or qualitative analysis is a key element of the assessment of the safety of geological disposal systems. As an outcome of an international workshop attended by European and the Japanese implementers, a number of features common to current methodologies could be identified, as well as trends in their evolution over time. In the late nineties, scenario development was often described as a bottom-up process, whereby scenarios were said to be developed in essence from FEP databases. Nowadays, it is recognised that, in practice, the approaches actually adopted are better described as top-down or 'hybrid', taking as their starting point an integrated (top-down) understanding of the system under consideration including uncertainties in initial state, sometimes assisted by the development of 'storyboards'. A bottom-up element remains (hence the term 'hybrid') to the extent that FEP databases or FEP catalogues (including interactions) are still used, but the focus is generally on completeness checking, which occurs parallel to the main assessment process. Recent advances focus on the consistent treatment of uncertainties throughout the safety assessment and on the integration of operational safety and long term safety. (author)

Microporous polyethylene separators — today and tomorrow. Separator development trends for modern automotive batteries

Science.gov (United States)

Böhnstedt, Werner

During the past decade, the design of modern automotive batteries has undergone a fundamental change. The introduction of microporous polyethylene pocket separators has resulted in an approximately 8% better volume utilization. Besides increasing the energy density, the polyethylene envelope has enalbed an improvement in cold-cranking performance and has raised the production efficiency. A first failure-mode analysis of pocket-separated automotive batteries in Europe with respect to leaf separation is presented. For comparable service life, a shift in failure mode has been found. Although corrosion of the positive electrode still dominates, a significant increase in positive active-material shedding is noted. This is certainly a consequence of the general trend towards lower antimony contents. Shorting through the separator is only found in cases of severe battery mistreatment. This positive, intermediary result is supplemented by an outlook on emerging development trends. Future automotive batteries will experience elevated operating temperatures, higher cycling loads, and maintenance freedom. Battery tests at temperatures up to 75 °C with various alloy combinations show that the hybrid design is best suited to meet the expected requirements. Microporous polyethylene pocket separation is not expected to be a limiting factor; the trend to lower antimony alloy content and increased cycling load will demonstrate the advantage of this separation even more clearly than in the past. Optimization of the already achieved, balanced separator characteristics profile with the reference parameters of electrical performance, water loss, durability and machinability will stimulate further development work.

Genetic Interactions of STAT3 and Anticancer Drug Development

International Nuclear Information System (INIS)

Fang, Bingliang

2014-01-01

Signal transducer and activator of transcription 3 (STAT3) plays critical roles in tumorigenesis and malignant evolution and has been intensively studied as a therapeutic target for cancer. A number of STAT3 inhibitors have been evaluated for their antitumor activity in vitro and in vivo in experimental tumor models and several approved therapeutic agents have been reported to function as STAT3 inhibitors. Nevertheless, most STAT3 inhibitors have yet to be translated to clinical evaluation for cancer treatment, presumably because of pharmacokinetic, efficacy, and safety issues. In fact, a major cause of failure of anticancer drug development is lack of efficacy. Genetic interactions among various cancer-related pathways often provide redundant input from parallel and/or cooperative pathways that drives and maintains survival environments for cancer cells, leading to low efficacy of single-target agents. Exploiting genetic interactions of STAT3 with other cancer-related pathways may provide molecular insight into mechanisms of cancer resistance to pathway-targeted therapies and strategies for development of more effective anticancer agents and treatment regimens. This review focuses on functional regulation of STAT3 activity; possible interactions of the STAT3, RAS, epidermal growth factor receptor, and reduction-oxidation pathways; and molecular mechanisms that modulate therapeutic efficacies of STAT3 inhibitors

[The trend of new drug development for the treatment of diabetes mellitus].

Science.gov (United States)

Kaku, Kohei

2015-12-01

The trend of new drug development in the field of diabetes mellitus is overviewed. The hypoglycemic drugs such as glucagon receptor antagonists, glucokinase activators, and GPR agonists and oral medication of GLP-1 receptor agonist are under phase 2 trial in Japan. As for therapeutic medicines for diabetic nephropathy, atrasentan as an endothelin A receptor antagonist is in phase 3 trial, and bardoxolone methyl as Nrf2 activator in phase 2 in Japan. Canagliflozin, a SGLT2 inhibitor, is in phase 3 study to obtain new indication of diabetic nephropathy. An environment surrounding development of therapeutic medicines for diabetes has been tough since FDA guidance in 2008.

Trends in global approvals of biotech crops (1992-2014).

Science.gov (United States)

Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

2015-01-01

With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

Do gender and personality traits (BFI-10) influence attitude towards genetic research?

DEFF Research Database (Denmark)

Sudzina, Frantisek

2016-01-01

There is a continuing trend of making genetic research commercially available. It is not only 23andme that offers various types of genetic tests anymore. People do not need to rely on doctor's opinion, they can purchase genetic testing kits and test themselves. Unfortunately, not all available te...... tests are reliable; as the case of Theranos showed recently. The paper aims to investigate if there is any impact of gender and of personality traits on attitude towards genetic research. Big Five Inventory is used to measure personality traits....

Trends in computer hardware and software.

Science.gov (United States)

Frankenfeld, F M

1993-04-01

Previously identified and current trends in the development of computer systems and in the use of computers for health care applications are reviewed. Trends identified in a 1982 article were increasing miniaturization and archival ability, increasing software costs, increasing software independence, user empowerment through new software technologies, shorter computer-system life cycles, and more rapid development and support of pharmaceutical services. Most of these trends continue today. Current trends in hardware and software include the increasing use of reduced instruction-set computing, migration to the UNIX operating system, the development of large software libraries, microprocessor-based smart terminals that allow remote validation of data, speech synthesis and recognition, application generators, fourth-generation languages, computer-aided software engineering, object-oriented technologies, and artificial intelligence. Current trends specific to pharmacy and hospitals are the withdrawal of vendors of hospital information systems from the pharmacy market, improved linkage of information systems within hospitals, and increased regulation by government. The computer industry and its products continue to undergo dynamic change. Software development continues to lag behind hardware, and its high cost is offsetting the savings provided by hardware.

Technological trends in energy industry

International Nuclear Information System (INIS)

Martin Moyano, R.

1995-01-01

According to the usual meaning, technological trends are determined by main companies and leading countries with capacity for the development and marketing of technology. Presently, those trends are addressed to: the development of cleaner and more efficient process for fossil fuels utilization (atmospheric and pressurized fluidized beds, integrated gasification in combined cycle, advanced combined cycles, etc), the development of safer and more economic nuclear reactors; the efficiency increase in both generation and utilisation of energy, including demand side management and distribution automation; and the reduction of cost of renewable energies. Singular points of these trends are: the progress in communication technologies (optical fibre, trucking systems, etc.); the fuel cells; the supercritical boilers; the passive reactors; the nuclear fusion; the superconductivity; etc. Spain belongs to the developed countries but suffer of certain technology shortages that places it in a special situation. (Author)

International and Domestic Development Trends of Electromagnetic Transient Analysis Programs for Power Systems

Science.gov (United States)

Noda, Taku

Nowadays, there is quite high demand for electromagnetic transient (EMT) analysis programs and real-time simulators for power systems. In addition to the conventional demand such as overvoltage, over-current and oscillation simulations, the new demand that includes simulations of power-electronics circuits and power quality is increasing. With this background, development groups of EMT programs and real-time simulators have made progress in terms of computational performance and user experience. In Japan, Central Research Institute of Electric Power Industry has newly developed an EMT analysis program called XTAP (eXpandable Transient Analysis Program). This article overviews these international and domestic development trends of EMT analysis programs and real-time simulators.

A Secular Indicator Of the Degree Of Economic Development and Synthetic Evaluation Of Population Well-Being Trends

Directory of Open Access Journals (Sweden)

Gheorghe Săvoiu

2015-12-01

Full Text Available he specifically multidisciplinary approach employed in the present paper is motivated by the validity of Engel’s sociological laws, the usefulness of the elasticity of the population’s food products demand according to income, the statistical association between the contraction of the share of expenditures for these goods and the expansion of economy development, and the consistent assessment of the trends in population well-being, in keeping with the research of family budgets, focusing on the case of Romania in the last century. The introduction is devoted to the statistical, economic and sociological tools for assessing economic development and the trends in well-being. The first section describes the weighting coefficients in the universe of interpret indexes, and the second presents the methodology relating to a secular instrument of assessing the degree of economic development and the synthetic evaluation of the trends of well-being in Romania, in parallel to a number of maximum and minimum (European and international trends. The results presented, and the discussion caused by the statistical confrontation of that statistical, economic and sociological information, embrace, with the conclusions, the attempt made by the whole of the paper, to round up, by means of this tool, a necessary set of secular or Schumpeterian indicators, harmonized and comparable, of the GDP/capita type, or such as cost of life index, consumer price index, public and external debt, etc.; such already constructed indicators contribute to delineating the historical and macro-behavioural specificity of such an economy in Eastern Europe as that of Romania.

Emerging trends in informal sector recycling in developing and transition countries

International Nuclear Information System (INIS)

Ezeah, Chukwunonye; Fazakerley, Jak A.; Roberts, Clive L.

2013-01-01

Highlights: • Reviewed emerging trends in Informal Sector Recycling (ISR) in developing countries. • In some countries we found that ISR is the key factor in the recycling of waste materials. • Overall impact of ISR upon the urban economy and environment is positive. • In some instances ISR subsidises large areas of the formal sector. • Ignoring the informal sector could result in unsustainable interventions. - Abstract: Optimistic estimates suggest that only 30–70% of waste generated in cities of developing countries is collected for disposal. As a result, uncollected waste is often disposed of into open dumps, along the streets or into water bodies. Quite often, this practice induces environmental degradation and public health risks. Notwithstanding, such practices also make waste materials readily available for itinerant waste pickers. These ‘scavengers’ as they are called, therefore perceive waste as a resource, for income generation. Literature suggests that Informal Sector Recycling (ISR) activity can bring other benefits such as, economic growth, litter control and resources conservation. This paper critically reviews trends in ISR activities in selected developing and transition countries. ISR often survives in very hostile social and physical environments largely because of negative Government and public attitude. Rather than being stigmatised, the sector should be recognised as an important element for achievement of sustainable waste management in developing countries. One solution to this problem could be the integration of ISR into the formal waste management system. To achieve ISR integration, this paper highlights six crucial aspects from literature: social acceptance, political will, mobilisation of cooperatives, partnerships with private enterprises, management and technical skills, as well as legal protection measures. It is important to note that not every country will have the wherewithal to achieve social inclusion and so the

Emerging trends in informal sector recycling in developing and transition countries

Energy Technology Data Exchange (ETDEWEB)

Ezeah, Chukwunonye, E-mail: C.Ezeah2@wlv.ac.uk; Fazakerley, Jak A.; Roberts, Clive L.

2013-11-15

Highlights: • Reviewed emerging trends in Informal Sector Recycling (ISR) in developing countries. • In some countries we found that ISR is the key factor in the recycling of waste materials. • Overall impact of ISR upon the urban economy and environment is positive. • In some instances ISR subsidises large areas of the formal sector. • Ignoring the informal sector could result in unsustainable interventions. - Abstract: Optimistic estimates suggest that only 30–70% of waste generated in cities of developing countries is collected for disposal. As a result, uncollected waste is often disposed of into open dumps, along the streets or into water bodies. Quite often, this practice induces environmental degradation and public health risks. Notwithstanding, such practices also make waste materials readily available for itinerant waste pickers. These ‘scavengers’ as they are called, therefore perceive waste as a resource, for income generation. Literature suggests that Informal Sector Recycling (ISR) activity can bring other benefits such as, economic growth, litter control and resources conservation. This paper critically reviews trends in ISR activities in selected developing and transition countries. ISR often survives in very hostile social and physical environments largely because of negative Government and public attitude. Rather than being stigmatised, the sector should be recognised as an important element for achievement of sustainable waste management in developing countries. One solution to this problem could be the integration of ISR into the formal waste management system. To achieve ISR integration, this paper highlights six crucial aspects from literature: social acceptance, political will, mobilisation of cooperatives, partnerships with private enterprises, management and technical skills, as well as legal protection measures. It is important to note that not every country will have the wherewithal to achieve social inclusion and so the

A Novel Forward Genetic Screen for Identifying Mutations Affecting Larval Neuronal Dendrite Development in Drosophila melanogaster

OpenAIRE

Medina, Paul Mark B.; Swick, Lance L.; Andersen, Ryan; Blalock, Zachary; Brenman, Jay E.

2006-01-01

Vertebrate and invertebrate dendrites are information-processing compartments that can be found on both central and peripheral neurons. Elucidating the molecular underpinnings of information processing in the nervous system ultimately requires an understanding of the genetic pathways that regulate dendrite formation and maintenance. Despite the importance of dendrite development, few forward genetic approaches have been used to analyze the latest stages of dendrite development, including the ...

Mindfulness-based cognitive therapy for depression: trends and developments

Directory of Open Access Journals (Sweden)

MacKenzie MB

2016-05-01

Full Text Available Meagan B MacKenzie,1 Nancy L Kocovski21Department of Psychology, Ryerson University, Toronto, ON, Canada; 2Department of Psychology, Wilfrid Laurier University, Waterloo, ON, CanadaAbstract: Mindfulness-based cognitive therapy (MBCT was developed as a psychological intervention for individuals at risk of depressive relapse. Possible mechanisms of change for this intervention are in line with its theoretical underpinnings, and include increases in mindfulness and/or decreases in negative repetitive thoughts. This review provides an overview of current trends in MBCT research, including efficacy and questions regarding the specific effects of MBCT in light of recent comparisons with structurally equivalent control conditions, mechanisms of change, and moderators of treatment outcome. In addition, future directions are discussed, such as challenges with training an adequate number of therapists and disseminating this therapy.Keywords: MBCT, efficacy, mechanisms of change, dissemination, moderators

Trends and Developments of Higher Education Research in Hong Kong: In Pursuit of a Cosmopolitan Vision

Science.gov (United States)

Lo, William Yat Wai; Ng, Felix Sai Kit

2015-01-01

With the processes of inter- and intranationalization, higher education in Hong Kong has been rapidly expanding in an effort to develop the city into a regional education hub. This article explores the trends and developments of higher education research (HER) in Hong Kong in the context of inter- and intranationalization. By drawing on the data…

Financial potential and economic development trend of Chuvash Republic, Russian Federation

Directory of Open Access Journals (Sweden)

Lyubovtseva E.G.

2017-01-01

Full Text Available this article discusses the economic potential and development trend of Chuvash Republic. All important economic indicators of Chuvash Republic like, Gross Regional Production (GRP, employment, export, import, performance of credit organization, per capita income have been taken into consideration to analyze economic performance. This paper also shows how any increase in per capita income effects socio-economic condition. Finally, this paper proposes adequate and proper measures to improve the efficiency and effectiveness in policy formation and use of financial resources in Chuvash Republic on the basis of analysis. Only secondary source of data has been used for analysis.

Gender gaps in life expectancy: generalized trends and negative associations with development indices in OECD countries.

Science.gov (United States)

Liu, Yan; Arai, Asuna; Kanda, Koji; Lee, Romeo B; Glasser, Jay; Tamashiro, Hiko

2013-08-01

Life expectancy (LE) is a major marker of individual survival. It also serves as a guide to highlight both the progress and the gaps in total social and societal health. Comparative LE in concert with measures of gender-specific experience, indices of empowerment and societal happiness and development offer a comparative tool to examine trends and similarities of societal progress as seen through the lens of cross-national experience. To determine the gender gaps in LE (GGLE) trends, we performed a longitudinal analysis, covering a period of 49 years (1960-2008). To examine the association of GGLE with development indices, we used the 2007 GGLE data, the newest happiness data mostly drawn from 2006; the 2006 Human Development Index (HDI) data and the 2006 Gender Empowerment Measure (GEM) data. It revealed that most of the Organization for Economic Co-operation and Development (OECD) countries had a GGLE trend that occurred in an inverted U-curve fashion. We divided them into three subgroups based on the peak years of respective GGLE. The earlier the peak year, the happier the countries, the higher the HDI and the smaller the current GGLE are. Association analysis indicates that Happiness, HDI and GEM are all negatively associated with GGLE. This pattern suggests that GGLE undergoes three phases of growth, peak and stability and decline. Japan will soon be seeing its GGLE gradually shrinking in the foreseeable future. The continuing increases in Happiness, HDI and GEM are associated with a decrease in GGLE, which should be carefully taken into consideration.

Development of genetic diversity, differentiation and structure over 500 years in four ponderosa pine populations.

Science.gov (United States)

Lesser, M R; Parchman, T L; Jackson, S T

2013-05-01

Population history plays an important role in shaping contemporary levels of genetic variation and geographic structure. This is especially true in small, isolated range-margin populations, where effects of inbreeding, genetic drift and gene flow may be more pronounced than in large continuous populations. Effects of landscape fragmentation and isolation distance may have implications for persistence of range-margin populations if they are demographic sinks. We studied four small, disjunct populations of ponderosa pine over a 500-year period. We coupled demographic data obtained through dendroecological methods with microsatellite data to discern how and when contemporary levels of allelic diversity, among and within-population levels of differentiation, and geographic structure, arose. Alleles accumulated rapidly following initial colonization, demonstrating proportionally high levels of gene flow into the populations. At population sizes of approximately 100 individuals, allele accumulation saturated. Levels of genetic differentiation among populations (F(ST) and Jost's D(est)) and diversity within populations (F(IS)) remained stable through time. There was no evidence of geographic genetic structure at any time in the populations' history. Proportionally, high gene flow in the early stages of population growth resulted in rapid accumulation of alleles and quickly created relatively homogenous genetic patterns among populations. Our study demonstrates that contemporary levels of genetic diversity were formed quickly and early in population development. How contemporary genetic diversity accumulates over time is a key facet of understanding population growth and development. This is especially relevant given the extent and speed at which species ranges are predicted to shift in the coming century. © 2013 Blackwell Publishing Ltd.

Development trends of remote sensing technology for uranium exploration in 12th Five Year

International Nuclear Information System (INIS)

Zhang Jielin

2011-01-01

This paper introduced the research status,application requirements, technique questions and development trends of remote sensing technology for uranium exploration in the 12th five year, and discussed the applicant prospects and potential of applied basic research innovation, thermal infrared hyperspectral and microwave remote sensing, 4D geological mapping and stereo exploration model in the uranium exploration. (authors)

Analysis of the development trend of China’s business administration based on time series

OpenAIRE

Jiang Rui

2016-01-01

On the general direction of the economic system, China is in a crucial period of the establishment of the modern enterprise system and reform of the macroeconomic system, and a lot of high-quality business administration talents are required to make China’s economy be stably developed. This paper carries out time series analysis of the development situation of China’s business administration major: on the whole, the society currently presents an upward trend on the demand for the business adm...

Development Situation, Trend and Countermeasure of Consumer-level UAV Market in China

Directory of Open Access Journals (Sweden)

Kang Yu-Lei

2017-01-01

Full Text Available This paper is based on the status of Chinese consumer-level UAV(Unmanned Aerial Vehicle market. According to the main problems in Chinese consumer-level UAV market, the author analyses the trends of Chinese consumer-level UAV market. Then, the author put forward some suggestions to develop Chinese consumer-level UAV market. In 21st century, the research and development expenditure presents the explosive growth in Chinese consumer-level UAV market. From the year of 2012, DJI released their first consumer-level UAV product. Amazon, Facebook, Google and other companies have announced their entry into the UAV market. In 2016, Huawei also announced that it will enter the UAV market.

[Current options of preimplantion genetic screening and preimplantation genetic diagnostics].

Science.gov (United States)

Šimečková, V

The aim of this work is to summarize the current knowledge about preimplantation genetic screening and diagnostics. A review article. Department of Gynecology and Obstetrics, District Hospital Šternberk, IVF Clinic, Olomouc. Preimplantation genetic testing is a complex of genetic and molecular cytogenetic examinations, which can help to detect abnormalities in embryos before transfer into the uterus of the mother. These specialized examinations are based on the latest findings in genetics and assisted reproduction. The preimplantation genetic testing is necessarily associated with a method of in vitro fertilization. It is performed on isolated blastomeres on the third day of embryo cultivation. Nowadays, it is preferred trophectoderm examination of cells from the five-day blastocysts. Generally speaking, after preimplantation genetic testing, we can select only embryos without genetic load to transfer into uterus. Preimplantation genetic testing is an important part of treatment of infertility. Complex diagnostics and treatment of infertile couples are increasingly influenced by the development and use of advanced genomic technologies. Further development and application of these modern methods require close cooperation between the field of assisted reproduction and clinical genetics.

Trends of development of social responsible investment in Ukraine: accounting principles

Directory of Open Access Journals (Sweden)

Rudeychuk S.V.

2017-08-01

Full Text Available The research is devoted to the study of the features and trends of the development of socially responsible investment in Ukraine. The main objective of the study of social responsibility issues is to systematize and study the prospects for the development and evaluation of corporate social responsibility in Ukraine, as well as to study the peculiarities of its accounting reflection in the accounting system. In the course of the study, the current state of social projects in Ukraine was studied, as well as the main obstacles and perspectives of the development of socially responsible investment in Ukraine. The research defines the features of socially responsible investment in order to identify the main areas of improvement of the information provision of formation of social reporting indicators. The article proposes the bookkeeping for directions of enterprise’s social activity in clearly defined accounts of accounting, regardless of the level of its regulation, followed by the development of analytical sections of accounting in the relevant areas of social policy.

Computing in research and development in Africa benefits, trends, challenges and solutions

CERN Document Server

2015-01-01

This book describes the trends, challenges and solutions in computing use for scientific research and development within different domains in Africa, such as health, agriculture, environment, economy, energy, education and engineering. The benefits expected are discussed by a number of recognized, domain-specific experts, with a common theme being computing as solution enabler. This book is the first document providing such a representative up-to-date view on this topic at the continent level.   • Discusses computing for scientific research and development on the African continent, addressing domains such as engineering, health, agriculture, environment, economy, energy, and education; • Describes the state-of-the-art in usage of computing to address problems in developing countries pertaining to health, productivity, economic growth, and renewable energy; • Offers insights applicable to all developing countries on the use of computing technologies to address a variety of societal issues.

TRENDS AND MARKETS IN THE DEVELOPMENT OF PRODUCTION AND TRADE WITH ROMANIAN PRODUCTS

Directory of Open Access Journals (Sweden)

Pop Cohut Ioana

2009-05-01

Full Text Available The current stage of retail trade development in Romania still shows an important capacity to absorb, both of large outlets as well as of small outlets, which lately have disappeared from the market and they hardly cope with the superstore competition. A part of the market which has been yet insufficiently explored, with an important potential for development and which is represented by the stores selling traditional Romanian products, as well as the bio product stores, as long as these are made in Romania and are not imported. Also, the paper is trying to analyse the importance of this type of trade and its trends, its lacks and the possibilities of development.

The Status Quo and Developing Trend Analysis of Global Carbon Finance

Institute of Scientific and Technical Information of China (English)

Liu Qian; Wang Yao

2011-01-01

This paper gives a systematic view of the new trends of global carbon finance innovation under the challenge of global climate change and in the process of transition to achieve economic growth from ＂high carbon＂ to ＇low carbon＇, covering the following aspects： the structure, status quo and developing trend of global carbon market. The paper discusses the innovation in financial organization and service systems and governments＇ overall guidance and policy support, and draws the conclusion that the world is undergoing massive changes with governments actively responding to carbon finance to embrace the tremendous opportunities for clean energy and climate change in financial industry. To seize the opportunity, a complete and overall carbon finance system of China should be put in the top of the agenda. Given the current tasks of energy conservation and pollution reduction and the growing demand for capital input, China needs to construct an clear of policy guidance, a diversified financia service system, and a multi-approach carbon finance system to intensify and widen the participation of financial industry, to expand financing channels for sustainable economy and spread risks, and finally, work out an inexpensive solution to the realization of China＇s low carbon target.

Development of a Framework for Genetic Algorithms

OpenAIRE

Wååg, Håkan

2009-01-01

Genetic algorithms is a method of optimization that can be used tosolve many different kinds of problems. This thesis focuses ondeveloping a framework for genetic algorithms that is capable ofsolving at least the two problems explored in the work. Otherproblems are supported by allowing user-made extensions.The purpose of this thesis is to explore the possibilities of geneticalgorithms for optimization problems and artificial intelligenceapplications.To test the framework two applications are...

Current nondestructive evaluation research and development trends in the United States

International Nuclear Information System (INIS)

Jackson, Jerry

1992-01-01

An underlying theme present in much of the nondestructive evaluation (NDE) research and development occurring in the United States as well as worldwide is the application of physics and engineering principles toward understanding and optimizing NDE processes. Expanding this trend of using mathematical models for NDE processes is critical to the entire spectrum of NDE technology. In NDE research, modeling anchors the investigation in scientific, proven principles and establishes a firm technical basis to guide the design and development of inspection equipment and approaches. It also provides for understanding the capabilities and the limitations of whatever designs are selected and ultimately applied in the field. This paper reviews the status of these efforts, presents several examples where mathematical modeling is being profitably used for practical inspection work, and shows the path being taken in ongoing research.

Genetic and environmental influences on thin-ideal internalization across puberty and preadolescent, adolescent, and young adult development.

Science.gov (United States)

Suisman, Jessica L; Thompson, J Kevin; Keel, Pamela K; Burt, S Alexandra; Neale, Michael; Boker, Steven; Sisk, Cheryl; Klump, Kelly L

2014-11-01

Mean-levels of thin-ideal internalization increase during adolescence and pubertal development, but it is unknown whether these phenotypic changes correspond to developmental changes in etiological (i.e., genetic and environmental) risk. Given the limited knowledge on risk for thin-ideal internalization, research is needed to guide the identification of specific types of risk factors during critical developmental periods. The present twin study examined genetic and environmental influences on thin-ideal internalization across adolescent and pubertal development. Participants were 1,064 female twins (ages 8-25 years) from the Michigan State University Twin Registry. Thin-ideal internalization and pubertal development were assessed using self-report questionnaires. Twin moderation models were used to examine if age and/or pubertal development moderate genetic and environmental influences on thin-ideal internalization. Phenotypic analyses indicated significant increases in thin-ideal internalization across age and pubertal development. Twin models suggested no significant differences in etiologic effects across development. Nonshared environmental influences were most important in the etiology of thin-ideal internalization, with genetic, shared environmental, and nonshared environmental accounting for approximately 8%, 15%, and 72%, respectively, of the total variance. Despite mean-level increases in thin-ideal internalization across development, the relative influence of genetic versus environmental risk did not differ significantly across age or pubertal groups. The majority of variance in thin-ideal internalization was accounted for by environmental factors, suggesting that mean-level increases in thin-ideal internalization may reflect increases in the magnitude/strength of environmental risk across this period. Replication is needed, particularly with longitudinal designs that assess thin-ideal internalization across key developmental phases. © 2014 Wiley

Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.

Science.gov (United States)

Matthes, Michaela; Preusse, Martin; Zhang, Jingzhong; Schechter, Julia; Mayer, Daniela; Lentes, Bernd; Theis, Fabian; Prakash, Nilima; Wurst, Wolfgang; Trümbach, Dietrich

2014-01-01

The study of developmental processes in the mouse and other vertebrates includes the understanding of patterning along the anterior-posterior, dorsal-ventral and medial- lateral axis. Specifically, neural development is also of great clinical relevance because several human neuropsychiatric disorders such as schizophrenia, autism disorders or drug addiction and also brain malformations are thought to have neurodevelopmental origins, i.e. pathogenesis initiates during childhood and adolescence. Impacts during early neurodevelopment might also predispose to late-onset neurodegenerative disorders, such as Parkinson's disease. The neural tube develops from its precursor tissue, the neural plate, in a patterning process that is determined by compartmentalization into morphogenetic units, the action of local signaling centers and a well-defined and locally restricted expression of genes and their interactions. While public databases provide gene expression data with spatio-temporal resolution, they usually neglect the genetic interactions that govern neural development. Here, we introduce Mouse IDGenes, a reference database for genetic interactions in the developing mouse brain. The database is highly curated and offers detailed information about gene expressions and the genetic interactions at the developing mid-/hindbrain boundary. To showcase the predictive power of interaction data, we infer new Wnt/β-catenin target genes by machine learning and validate one of them experimentally. The database is updated regularly. Moreover, it can easily be extended by the research community. Mouse IDGenes will contribute as an important resource to the research on mouse brain development, not exclusively by offering data retrieval, but also by allowing data input. http://mouseidgenes.helmholtz-muenchen.de. © The Author(s) 2014. Published by Oxford University Press.

non-genetic factors and correlation studies in cattle.

African Journals Online (AJOL)

Bivariate and multivariate analyses fitting an animal model, were conducted by means of (ASREML) ... aggregate genetic improvement in beef cattle is most ..... This trend was observed in the present study. .... effects hence the prediction of correlated responses to ... the shape of the growth curve as an animal can be.

Development of time-trend model for analysing and predicting case pattern of dog bite injury induced rabies-like-illness in Liberia, 2014-2017.

Science.gov (United States)

Jomah, N D; Ojo, J F; Odigie, E A; Olugasa, B O

2014-12-01

The post-civil war records of dog bite injuries (DBI) and rabies-like-illness (RLI) among humans in Liberia is a vital epidemiological resource for developing a predictive model to guide the allocation of resources towards human rabies control. Whereas DBI and RLI are high, they are largely under-reported. The objective of this study was to develop a time model of the case-pattern and apply it to derive predictors of time-trend point distribution of DBI-RLI cases. A retrospective 6 years data of DBI distribution among humans countrywide were converted to quarterly series using a transformation technique of Minimizing Squared First Difference statistic. The generated dataset was used to train a time-trend model of the DBI-RLI syndrome in Liberia. An additive detenninistic time-trend model was selected due to its performance compared to multiplication model of trend and seasonal movement. Parameter predictors were run on least square method to predict DBI cases for a prospective 4 years period, covering 2014-2017. The two-stage predictive model of DBI case-pattern between 2014 and 2017 was characterised by a uniform upward trend within Liberia's coastal and hinterland Counties over the forecast period. This paper describes a translational application of the time-trend distribution pattern of DBI epidemics, 2008-2013 reported in Liberia, on which a predictive model was developed. A computationally feasible two-stage time-trend permutation approach is proposed to estimate the time-trend parameters and conduct predictive inference on DBI-RLI in Liberia.

TRENDS REGARDING THE ROLE OF STATE ENTITIES IN SUPPORTING GROWTH AND ECONOMIC DEVELOPMENT

Directory of Open Access Journals (Sweden)

Florin Bonciu

2018-04-01

Full Text Available The paper focuses on the analysis of the consequences of several phenomena that have occurred in the past two decades in respect of the role played by state entities in supporting growth and economic development. Demographic and technical-scientific developments related to the Fourth Industrial Revolution were among the phenomena leading to an increasing trend in the role of state entities in supporting economic growth and development. In the meantime, other phenomena, including new technologies, economic integration and socio-cultural and historical processes, had a diminishing effect on the role played by state entities in supporting growth and economic development. By comparing the two categories of phenomena, the paper concludes that the phenomena supporting an increase in the role of state entities are more numerous and substantial, a fact that may assist decision-makers in developing appropriate approaches and strategies.

Trends in innovation activities in manufacturing industries across development echelons

Directory of Open Access Journals (Sweden)

Abdullah M. Khan

2017-07-01

Full Text Available This empirical paper explores trends in innovation activities measured by a countries’ total patent application submission intensity relative to its population, and by analyzing U.S. granted patents data for cohorts of developed countries and developing countries. In addition to tabular and graphical analyses, I use a baseline regression model and a variant model thereof to assess the relative influence of a set of aggregate variables on innovation activities in eight manufacturing industries across two cohorts of countries (developed and developing where each cohort contains eight individual countries. Eight industries included in this study are: Chemical, Petroleum, electrical and electronics equipment, machinery, pharmaceutical, plastic, computer, and textile. The cohort of developed countries includes Australia, Canada, Czech Republic, France, Italy, Poland, Switzerland, and the United States. The cohort of developing countries includes Brazil, China, India, Malaysia, Mexico, Russia, South Africa, and Turkey. Per regression results, ethnic diversity is a statistically significant positive determinant of innovation for all industry aggregate patent count for both high income and developing countries. Also, per capita electricity usage, R&D expenditure as percent of GDP, and percent of population with internet access are three positive factors of innovation irrespective of industrial subsectors and position of a country in the development echelon. Interestingly, impact of ICT-services export is statistically significant and innovation boosting in developing countries in the cohort relative to countries in the cohort of developed countries. It also appears that trade openness served as a stronger stimulant of innovation activities for developing countries’ but not as much for the cohort of developed or high-income countries. This paper attempts to extend the literature on cross-country comparison of innovation activities by using two

[Research progress and development trend of quantitative assessment techniques for urban thermal environment.

Science.gov (United States)

Sun, Tie Gang; Xiao, Rong Bo; Cai, Yun Nan; Wang, Yao Wu; Wu, Chang Guang

2016-08-01

Quantitative assessment of urban thermal environment has become a focus for urban climate and environmental science since the concept of urban heat island has been proposed. With the continual development of space information and computer simulation technology, substantial progresses have been made on quantitative assessment techniques and methods of urban thermal environment. The quantitative assessment techniques have been developed to dynamics simulation and forecast of thermal environment at various scales based on statistical analysis of thermal environment on urban-scale using the historical data of weather stations. This study reviewed the development progress of ground meteorological observation, thermal infrared remote sensing and numerical simulation. Moreover, the potential advantages and disadvantages, applicability and the development trends of these techniques were also summarized, aiming to add fundamental knowledge of understanding the urban thermal environment assessment and optimization.

INTERNATIONAL EXPERIENCE AND TRENDS OF INNOVATIVE DEVELOPMENT OF ARCTIC TERRITORIES

Directory of Open Access Journals (Sweden)

M. Dudin

2015-01-01

Full Text Available In this article and summarized the regularities of formation of foreign experience and trends of development of Arctic territories. Set out the important points predetermine orientation and specificity of manifestations of national interests – potential participants of the subsoil in the Arctic zone. On the basis of the illuminated materials were obtained the following conclusions: Signifi cant interest in the Arctic show today, not only the fi ve countries (Russia, USA, Canada, Norway, Denmark, who own Arctic territories, but also polar state (Iceland, Sweden, Finland, the European Union and Asia. As a consequence of that, it is expected that in the XXI century the Arctic region will be the focus of attention as an official Arctic 45, and a number of states whose territory is quite removed from it; For Russia, given the current, acute political conditions (sanctions, confrontation with the West, Ukrainian crisis and war in the Middle East development of Arctic territories, some moved away, moved on tomorrow and the day after tomorrow on the agenda. This approach is fundamentally fl awed and fraught with a number of threats, because other countries do not decrease, but only increase their interest in this issue; Territorial opposition to all those involved in the topic of causing instability in the Arctic region, but does not represent a real threat for the emergence of large-scale conflict. Therefore, making the choice between the hard pressure of national interests and the interests of harmonization of the Arctic states, Russia must be based on international cooperationand mutual consideration of interests in the development of its Arctic strategy; Considering the cooperation of the countries of the Arctic Council and their cooperation in the framework of a global economic forum G8, there are prerequisites for the decision of the Arctic confl ict through negotiation and compromise. In this context it is very important to develop

Trends in global approvals of biotech crops (1992–2014)

Science.gov (United States)

Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

2015-01-01

ABSTRACT With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992–2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits. PMID:26039675

Genetic diversity and genetic structure of consecutive breeding generations of golden mandarin fish (Siniperca scherzeri Steindachner) using microsatellite markers.

Science.gov (United States)

Luo, X N; Yang, M; Liang, X F; Jin, K; Lv, L Y; Tian, C X; Yuan, Y C; Sun, J

2015-09-25

In this study, 12 polymorphic microsatellites were inves-tigated to determine the genetic diversity and structure of 5 consecu-tive selected populations of golden mandarin fish (Siniperca scherzeri Steindachner). The total numbers of alleles, average heterozyosity, and average polymorphism information content showed that the genetic diversity of these breeding populations was decreasing. Additionally, pairwise fixation index FST values among populations and Da values in-creased from F1 generation to subsequent generations (FST values from 0.0221-0.1408; Da values from 0.0608-0.1951). Analysis of molecular variance indicated that most genetic variations arise from individuals within populations (about 92.05%), while variation among populations accounted for only 7.95%. The allele frequency of the loci SC75-220 and SC101-222 bp changed regularly in the 5 breeding generations. Their frequencies were gradually increased and showed an enrichment trend, indicating that there may be genetic correlations between these 2 loci and breeding traits. Our study indicated that microsatellite markers are effective for assessing the genetic variability in the golden mandarin fish breeding program.

Chronic pancreatitis: diagnosis, classification, and new genetic developments.

Science.gov (United States)

Etemad, B; Whitcomb, D C

2001-02-01

The utilization of recent advances in molecular and genomic technologies and progress in pancreatic imaging techniques provided remarkable insight into genetic, environmental, immunologic, and pathobiological factors leading to chronic pancreatitis. Translation of these advances into clinical practice demands a reassessment of current approaches to diagnosis, classification, and staging. We conclude that an adequate pancreatic biopsy must be the gold standard against which all diagnostic approaches are judged. Although computed tomography remains the initial test of choice for the diagnosis of chronic pancreatitis, the roles of endoscopic retrograde pancreatography, endoscopic ultrasonography, and magnetic resonance imaging are considered. Once chronic pancreatitis is diagnosed, proper classification becomes important. Major predisposing risk factors to chronic pancreatitis may be categorized as either (1) toxic-metabolic, (2) idiopathic, (3) genetic, (4) autoimmune, (5) recurrent and severe acute pancreatitis, or (6) obstructive (TIGAR-O system). After classification, staging of pancreatic function, injury, and fibrosis becomes the next major concern. Further research is needed to determine the clinical and natural history of chronic pancreatitis developing in the context of various risk factors. New methods are needed for early diagnosis of chronic pancreatitis, and new therapies are needed to determine whether interventions will delay or prevent the progression of the irreversible damage characterizing end-stage chronic pancreatitis.

Genetic secrets: Protecting privacy and confidentiality in the genetic era. Final report

Energy Technology Data Exchange (ETDEWEB)

Rothstein, M.A. [ed.

1998-09-01

Few developments are likely to affect human beings more profoundly in the long run than the discoveries resulting from advances in modern genetics. Although the developments in genetic technology promise to provide many additional benefits, their application to genetic screening poses ethical, social, and legal questions, many of which are rooted in issues of privacy and confidentiality. The ethical, practical, and legal ramifications of these and related questions are explored in depth. The broad range of topics includes: the privacy and confidentiality of genetic information; the challenges to privacy and confidentiality that may be projected to result from the emerging genetic technologies; the role of informed consent in protecting the confidentiality of genetic information in the clinical setting; the potential uses of genetic information by third parties; the implications of changes in the health care delivery system for privacy and confidentiality; relevant national and international developments in public policies, professional standards, and laws; recommendations; and the identification of research needs.

The development of Metacognition test in genetics laboratory for undergraduate students

Science.gov (United States)

A-nongwech, Nattapong; Pruekpramool, Chaninan

2018-01-01

The purpose of this research was to develop a Metacognition test in a Genetics Laboratory for undergraduate students. The participants were 30 undergraduate students of a Rajabhat university in Rattanakosin group in the second semester of the 2016 academic year using purposive sampling. The research instrument consisted of 1) Metacognition test and 2) a Metacognition test evaluation form for experts focused on three main points which were an accurate evaluation form of content, a consistency between Metacognition experiences and questions and the appropriateness of the test. The quality of the test was analyzed by using the Index of Consistency (IOC), discrimination and reliability. The results of developing Metacognition test were summarized as 1) The result of developing Metacognition test in a Genetics Laboratory for undergraduate students found that the Metacognition test contained 56 items of open - ended questions. The test composed of 1) four scientific situations, 2) fourteen items of open - ended questions in each scientific situation for evaluating components of Metacognition. The components of Metacognition consisted of Metacognitive knowledge, which were divided into person knowledge, task knowledge and strategy knowledge and Metacognitive experience, which were divided into planning, monitoring and evaluating, and 3) fourteen items of scoring criteria divided into four scales. 2) The results of the item analysis of Metacognition in Genetics Laboratory for undergraduate students found that Index of Consistency between Metacognitive experiences and questions were in the range between 0.75 - 1.00. An accuracy of content equaled 1.00. The appropriateness of the test equaled 1.00 in all situations and items. The discrimination of the test was in the range between 0.00 - 0.73. Furthermore, the reliability of the test equaled 0.97.

Estimativas de parâmetros genéticos e de tendência fenotípica, genética e de ambiente de algumas características reprodutivas na raça Gir Estimates of genetic parameters and phenotypic, genetic and environmental trends of some reproductive traits in Gir cattle

Directory of Open Access Journals (Sweden)

E.S. Balieiro

1999-08-01

Full Text Available O objetivo do estudo foi estimar os parâmetros e as tendências fenotípica, genética e ambiental para idade ao primeiro parto (IPP e intervalo de partos (IDP na raça Gir, com o emprego de análises uni e bivariadas sob o método da máxima verossimilhança restrita, por meio de algoritmo livre de derivadas (MTDFREML, que ajusta o modelo animal. O modelo matemático adotado para estudo do IDP incluiu os efeitos fixos rebanho-ano de parto, época de parto e idade da vaca ao parto como covariável e os efeitos aleatórios de animal e ambiente permanente. Para a IPP, o modelo incluiu os efeitos fixos rebanho-ano de nascimento e época de nascimento e efeito de animal como aleatório. Por meio de análises bivariadas, as estimativas de herdabilidade foram 0,17 para IPP e 0,06 para IDP. A estimativa de repetibilidade para IDP foi 0,17. As correlações fenotípica, genética e de ambiente entre IPP e IDP foram, respectivamente, 0,06, 0,37 e 0,03. As mudanças anuais fenotípica, genética e de ambiente para IPP foram, respectivamente, -0,446±0,077 (PThe aims of the present study were to estimate genetic parameters, as well as phenotypic, genetic and environmental trends for age at first calving (AFC and calving intervals (CI on Gyr dairy breed, using a multivariate derivative-free restricted maximum likelihood (MTDFREML with an animal model. The mathematic model for calving interval included herd-year of calving, calving season, and the covariate age of cow as fixed effects, and animal, and permanent environment as random effects. The model for age at first calving included herd-year of birth and season of birth as fixed effects, and animal as random effect. Through the bivariate analyses, estimates of heritability were: for age at first calving 0.17 and for calving interval 0.06. The estimate of repeatability for calving interval was 0.17. The phenotypic, genetic and environmental correlations between age at first calving and calving interval

Genetics, health care, and public policy: an introduction to public health genetics

National Research Council Canada - National Science Library

Stewart, Alison

2007-01-01

... initiative About this book Further reading and resources Principles of public health The emergence of public health genetics The human genome project and 'genomic medicine' Community genetics Current developments in public health genetics Genomics and global health 2 Genetic science and technology Basic molecular genetics Genes and the geno...

(Mal)nutrition and the new epidemiological trend in a context of development and inequalities.

Science.gov (United States)

Souza, Nathália Paula de; Lira, Pedro Israel Cabral de; Fontbonne, Annick; Pinto, Fernanda Cristina de Lima; Cesse, Eduarda Ângela Pessoa

2017-07-01

The current context of intense social, economic and political transformations has contributed to changes in the health profile of the population and generated discussions about the impact of these changes on the reorganization of society. At the present moment, the increase in non-communicable illnesses and diseases raises major concerns about the paradox of malnutrition and obesity. Based on an in-depth reading and interpretation of texts, documents and databases, this article discusses issues related to nutrition, considering the dimensions of shortages and excesses, the evolution of nutrition over time, and the connection with the new epidemiological trend. We begin with a conceptual characterization, the historical background and the anthropological connections with the guiding theme of the article. We then describe the prevalence, distribution and secular trend of malnutrition and obesity, as well as the temporal relationship with the new epidemiological trend in Brazil within a context of development and inequalities. Finally, we reflect on the issue of (mal)nutrition in post-modernity, the new interests at stake in the health-disease process, as well as international experiences and strategies of partnerships designed to overcome these problems. We conclude by discussing some current advances and challenges in relation to the complexity and speed of contemporary changes.

Genetics educational needs in China: physicians' experience and knowledge of genetic testing.

Science.gov (United States)

Li, Jing; Xu, Tengda; Yashar, Beverly M

2015-09-01

The aims of this study were to explore the relationship between physicians' knowledge and utilization of genetic testing and to explore genetics educational needs in China. An anonymous survey about experience, attitudes, and knowledge of genetic testing was conducted among physicians affiliated with Peking Union Medical College Hospital during their annual health evaluation. A personal genetics knowledge score was developed and predictors of personal genetics knowledge score were evaluated. Sixty-four physicians (33% male) completed the survey. Fifty-eight percent of them had used genetic testing in their clinical practice. Using a 4-point scale, mean knowledge scores of six common genetic testing techniques ranged from 1.7 ± 0.9 to 2.4 ± 1.0, and the average personal genetics knowledge score was 2.1 ± 0.8. In regression analysis, significant predictors of higher personal genetics knowledge score were ordering of genetic testing, utilization of pedigrees, higher medical degree, and recent genetics training (P education. This study demonstrated a sizable gap between Chinese physicians' knowledge and utilization of genetic testing. Participants had high self-perceived genetics educational needs. Development of genetics educational platforms is both warranted and desired in China.Genet Med 17 9, 757-760.

Controversies, development and trends of biofuel industry in the world

Directory of Open Access Journals (Sweden)

WenJun Zhang

2012-09-01

Full Text Available Controversies, development and trends of biofuel industry in the world were discussed in present article. First-generation biofuels, i.e., grain and land based biofuels, occupied large areas of arable lands and severely constrained food supplies, are widely disputed. They have been replaced by second-generation biofuels. The raw materials of the second-generation biofuels include plants, straw, grass and other crops and forest residues. However, the cost for production of the second-generation biofuels is higher. Therefore the development of the third-generation biofuels is undergoing. The third-generation technologies use, mainly algae, as raw material to produce bioethanol, biobutanol, biodiesel and hydrogen, and use discarded fruits to produce dimethylfuran, etc. Different countries and regions are experiencing different stages of biofuel industry. In the future the raw materials for biofuel production will be focused on various by-products, wastes, and organisms that have not direct economic benefit for human. Production technologies should be improved or invented to reduce carbon emission and environmental pollution during biofuel production and to reduce production cost.

Etiological heterogeneity in the development of antisocial behavior: the Virginia Twin Study of Adolescent Behavioral Development and the Young Adult Follow-Up.

Science.gov (United States)

Silberg, Judy L; Rutter, Michael; Tracy, Kelly; Maes, Hermine H; Eaves, Lindon

2007-08-01

Longitudinal, genetically informed, prospective data collected on a large population of male twins (n=1037) were used to examine developmental differences in the etiology of antisocial behavior. Analyses were carried out on both mother- and child-reported symptoms of conduct disorder (CD) in 10- to 17-year-old twins from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) and self-reported antisocial behavior by the twins as young adults from the Young Adult Follow-Up (YAFU) study. The following trends were identified: (1) a single genetic factor influencing antisocial behavior beginning at age 10 through young adulthood ('life-course persistent'); (2) a shared-environmental effect beginning in adolescence ('adolescent-onset'); (3) a transient genetic effect at puberty; and (4) a genetic influence specific to adult antisocial behavior. Overall, these etiological findings are consistent with predictions from Moffitt's developmental theory of antisocial behavior. The genetic effect at puberty at ages 12-15 is also consistent with a genetically mediated influence on the timing of puberty affecting the expression of genetic differences in antisocial outcomes.

Conventional and genetic talent identification in sports: will recent developments trace talent?

Science.gov (United States)

Breitbach, Sarah; Tug, Suzan; Simon, Perikles

2014-11-01

The purpose of talent identification (TI) is the earliest possible selection of auspicious athletes with the goal of systematically maximizing their potential. The literature proposes excellent reviews on various facets of talent research on different scientific issues such as sports sciences or genetics. However, the approaches of conventional and genetic testing have only been discussed separately by and for the respective groups of interest. In this article, we combine the discoveries of these disciplines into a single review to provide a comprehensive overview and elucidate the prevailing limitations. Fundamental problems in TI reside in the difficulties of defining the construct ‘talent’ or groups of different performance levels that represent the target variable of testing. Conventional and genetic testing reveal a number of methodological and technical limitations, and parallels are summarised in terms of the test designs, the point in time of testing, psychological skills or traits and unknown interactions between different variables. In conclusion, many deficiencies in the current talent research have gained attention. Alternative solutions include the talent development approach, while genetic testing is re-emphasised as a tool for risk stratification in sport participation. Future research needs to clearly define the group of interest and comprehensively implement all methodological improvement suggestions.

Trends in Unmet Need for Genetic Counseling Among Children With Special Health Care Needs, 2001-2010.

Science.gov (United States)

Smith, Anna Jo; Oswald, Donald; Bodurtha, Joann

2015-01-01

Access to genetic counseling is increasingly important to guide families' and clinicians' decision making, yet there is limited research on accessibility and affordability of counseling for families with children with special health care needs (CSHCN). Our study's objectives were to measure changes in unmet need for genetic counseling for CSHCN from 2001 to 2010 and to characterize child, family, and health system factors associated with unmet need. We used parent-reported data from the 2001, 2005-2006, and 2009-2010 National Survey of Children With Special Health Care Needs. We used a logistic regression model to measure the impact of survey year, child (sex, age, severity of health condition), family (primary language, household income, insurance, financial problems related to cost of CSHCN's health care), and health system factors (region, genetic counselors per capita, having a usual source of care) on access to genetic counseling. Unmet need for genetic counseling increased significantly in 2009-2010 compared to 2001 (odds ratio 1.89; 95% confidence interval [CI] 1.44-2.47). Being older (adjusted odds ratio [aOR] 1.04; 95% CI 1.02-1.06), having severe health limitations (aOR 1.72; 95% CI 1.16-2.58), being uninsured (aOR 3.56; 95% CI 2.16-5.87), and having family financial problems due to health care costs (aOR 1.90; 95% CI 1.52-2.38) were significantly associated with greater unmet need for genetic counseling. Having a usual source of care was associated with decreased unmet need (aOR 0.55; 95% CI 0.37-0.83). Unmet need for genetic counseling has increased over the past 12 years. Uninsurance and financial problems related to health care costs were the largest drivers of unmet need over time. Copyright © 2015 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

Melanoma genetics

DEFF Research Database (Denmark)

Read, Jazlyn; Wadt, Karin A W; Hayward, Nicholas K

2015-01-01

Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of herita......Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence...... in a combined total of approximately 50% of familial melanoma cases, the underlying genetic basis is unexplained for the remainder of high-density melanoma families. Aside from the possibility of extremely rare mutations in a few additional high penetrance genes yet to be discovered, this suggests a likely...... polygenic component to susceptibility, and a unique level of personal melanoma risk influenced by multiple low-risk alleles and genetic modifiers. In addition to conferring a risk of cutaneous melanoma, some 'melanoma' predisposition genes have been linked to other cancers, with cancer clustering observed...

Nuclear power in the world. Its present status and development trends

International Nuclear Information System (INIS)

Bennett, L.

1994-01-01

A summary of the most important data about the nuclear power reactors in operation and under construction as of the end of 1993 is given: their capacity, share of world capacity, growth of nuclear electricity generation since 1970 and its distribution by country. Nuclear prospects in the medium (2015) and long term (2025) are connected with a broad range of factors: development of advanced reactors ensuring high level of safety, implementation of high level waste repositories, enhancing the public acceptance of nuclear power. The issue of the cost of electricity generation is also discussed. Nuclear capacity projections to 2015 by region are given with 'low' and 'high' estimates. The low case reflects the continuation of the present trend of stagnation in nuclear power development due to public opposition and low economic growth in OECD countries, uncertainties in Eastern Europe and lack of finding in developing countries. The high case reflects a moderate revival of nuclear power development in the light of a more comprehensive assessment of the macro-economic and environmental aspects of the different options available for electricity generation. 7 figs., 5 tabs. (R.T.)

[International trends of applied ecology and its future development in China].

Science.gov (United States)

Zhou, Qixing; Sun, Shunjiang

2002-07-01

Internationally applied ecology was born around 25-40 years ago in order to adapt and serve the needs of mitigating increasingly environmental pollution and ecological destroy in developed western countries at that time. All the times applied ecological principles thus underpin most efforts at solving increasingly deterioration of natural resources and serious eco-environmental problems as its keystone and researching kernel with the development of the subject. At the advent of the 21st century, human beings enter into the age of applied ecology. There are five international features of applied ecology, including more attention to many-sided applications, special emphasis on the intersection with engineering, strongly keeping on mutual links with basic ecology, omnidirectional adoption of new methods and new technology, and side-by-side trends of microcosmic mechanisms and macroscopical regulation. Although we must connect with international applied ecology and absorb distillates from the subject in developed western countries, development of applied ecology in China in the future, in particular, at the beginnings of the 21st century should not deviate from aiming at the solution of increasingly environmental pollution and ecological destroy that is one of the most important basic situations of the country.

Applying of modern development trends in the firm of the world class

Directory of Open Access Journals (Sweden)

Teplická Katarína

2004-06-01

Full Text Available The main goal all the world is situated to the nature of the excellent firm. The global business is orientated to increase the quality of product, to decrease the costs in the firm, to rise productivity, to reduce times between order and delivery et cetera. Every firm can obtain those conditions by a new trends on business. The implementation of the modern trends brings a lots advantages for the firm, that the firm becomes competitveable on the global business. This paper decribes the new modern trends which are used on business today.

Trend Analysis of Pahang River Using Non-Parametric Analysis: Mann Kendalls Trend Test

International Nuclear Information System (INIS)

Nur Hishaam Sulaiman; Mohd Khairul Amri Kamarudin; Mohd Khairul Amri Kamarudin; Ahmad Dasuki Mustafa; Muhammad Azizi Amran; Fazureen Azaman; Ismail Zainal Abidin; Norsyuhada Hairoma

2015-01-01

Flood is common in Pahang especially during northeast monsoon season from November to February. Three river cross station: Lubuk Paku, Sg. Yap and Temerloh were selected as area of this study. The stream flow and water level data were gathered from DID record. Data set for this study were analysed by using non-parametric analysis, Mann-Kendall Trend Test. The results that obtained from stream flow and water level analysis indicate that there are positively significant trend for Lubuk Paku (0.001) and Sg. Yap (<0.0001) from 1972-2011 with the p-value < 0.05. Temerloh (0.178) data from 1963-2011 recorded no trend for stream flow parameter but negative trend for water level parameter. Hydrological pattern and trend are extremely affected by outside factors such as north east monsoon season that occurred in South China Sea and affected Pahang during November to March. There are other factors such as development and management of the areas which can be considered as factors affected the data and results. Hydrological Pattern is important to indicate the river trend such as stream flow and water level. It can be used as flood mitigation by local authorities. (author)

The development of trend and pattern analysis methods for incident data by CEC'S joint research at Ispra

International Nuclear Information System (INIS)

Amesz, J.; Kalfsbeek, H.W.

1990-01-01

The Abnormal Occurrences Reporting System of the Commission of the European Communities was developed by the Joint Research Centre at Ispra in the period 1982 through 1985. It collects in a unique format all safety relevant events from NPPs as recorded in the participating countries. The system has been set-up with the specific objective of providing an advanced tool for a synoptic analysis of a large number of events, identifying patterns of sequences, trends, multiple dependencies between incident descriptors, precursors to severe incidents, performance indicators etc. This paper gives an overview of the development of trend and pattern analysis techniques of two different types: - event sequence analysis; - statistical methods. Though these methods have been developed and applied in relation with the AORS data, they can be regarded as generic in the sense that they may be applied to any incident reporting system satisfying the necessary criteria as to homogeneity and completeness, for rendering valid results

Maxillary canine displacement and genetically determined predisposition to disturbed development of the dentition.

Science.gov (United States)

Stahl, Franka; Grabowski, Rosemarie

2003-05-01

The relationship between maxillary canine displacement and the simultaneous occurrence of "genetically determined predisposition to disturbed development of the dentition" as defined by Hoffmeister was investigated in 675 patients. Panoramic radiographs taken of each patient during the first and the second mixed dentition periods were evaluated. Canine inclination and the distance between the tip of the canine and a line connecting the cusps of the molars were computed in five different age groups according to Dausch-Neumann. Statistical analysis revealed 34 patients with "potential canine displacement", who exhibited further symptoms of "genetically determined predisposition to disturbed development of the dentition" significantly more frequently than the total group. The symptoms concerned were agenesia, displaced tooth buds, rotated or tilted incisors, aplasia and microdontia of lateral incisors. Careful follow-ups in patients with a predisposition to disturbed dental development enables risks to be anticipated and canine displacement to be detected at an early stage.

STATE AND DEVELOPMENT PROSPECTS OF GERMANY CONSULTING MARKET IN THE CONTEXT OF EUROPE-WIDE TRENDS

Directory of Open Access Journals (Sweden)

K. Kovalska

2014-09-01

Full Text Available The paper deals with the actual state of consulting market in Germany. The structural configuration of the Germany consulting market on functional grounds, with the customer's branch, as well as geographically were analyzed. The main prospects of German consulting market development in the context of Europe-wide trends have been defined.

Possibilities and pitfalls for modern biotechnology in the development of African genetic toxicology

International Nuclear Information System (INIS)

Anwar, Wagida A.

2005-01-01

Developing countries are currently going through a transitional phase facing the new challenges of globalization and its potential negative impact. Research policy should highlight the need to mobilize resources for human resource development, networking, improved research culture, information sharing, and pragmatic use of research findings. Advancement in molecular genetics whether at the educational or research level should greatly progress in developing countries so as to improve diagnosis, treatment, understanding of disease risk factors, and prevention. Currently, there is a growing interest to genetic toxicology research, the use of different biomarkers, and genetic susceptibility testing, which can contribute effectively in risk assessment. Africa has unique environmental exposures and public health circumstances, which make it ideal for environmental mutagenicity and carcinogenicity research. There are exposures to chemical genotoxicants (e.g., automobile exhaust, pesticides, metals, and cytotoxic drugs) and to lifestyle factors (e.g., consumption of tobacco products) that have been linked to the expression of biological effects and to increased risk for cancer. Infections can be associated with cancer development when the environmental factors interact with the infection and lead to the enhancement of the carcinogenic process. The high prevalence of viral pathogens and the improper use of pesticides may endanger biological functions beyond those for which they originally manufactured. Biomarkers are used to detect the effects of pesticides before adverse clinical health occurs. The scientific community plays a crucial role in understanding the environmental causes of human health problems and through its collaboration with communities, industries, and government agencies can help in resolving health problems

Possibilities and pitfalls for modern biotechnology in the development of African genetic toxicology.

Science.gov (United States)

Anwar, Wagida A

2005-09-01

Developing countries are currently going through a transitional phase facing the new challenges of globalization and its potential negative impact. Research policy should highlight the need to mobilize resources for human resource development, networking, improved research culture, information sharing, and pragmatic use of research findings. Advancement in molecular genetics whether at the educational or research level should greatly progress in developing countries so as to improve diagnosis, treatment, understanding of disease risk factors, and prevention. Currently, there is a growing interest to genetic toxicology research, the use of different biomarkers, and genetic susceptibility testing, which can contribute effectively in risk assessment. Africa has unique environmental exposures and public health circumstances, which make it ideal for environmental mutagenicity and carcinogenicity research. There are exposures to chemical genotoxicants (e.g., automobile exhaust, pesticides, metals, and cytotoxic drugs) and to lifestyle factors (e.g., consumption of tobacco products) that have been linked to the expression of biological effects and to increased risk for cancer. Infections can be associated with cancer development when the environmental factors interact with the infection and lead to the enhancement of the carcinogenic process. The high prevalence of viral pathogens and the improper use of pesticides may endanger biological functions beyond those for which they originally manufactured. Biomarkers are used to detect the effects of pesticides before adverse clinical health occurs. The scientific community plays a crucial role in understanding the environmental causes of human health problems and through its collaboration with communities, industries, and government agencies can help in resolving health problems.

Plant breeding and genetics newsletter. No. 21, July 2008

International Nuclear Information System (INIS)

2008-07-01

A major milestone for our subprogramme will be the upcoming International Symposium on Induced Mutations in Plants, which will be held 12-15 August 2008 in Vienna, Austria. This will be the eighth in the Joint FAO/IAEA Programme?s Symposium series dedicated exclusively to harnessing and disseminating information on current trends in induced mutagenesis in plants, the first of which was held in 1969 and the most recent in 1995. These previous symposia dealt with themes relating to the development of efficient protocols for induced mutagenesis and their role in the enhancement of quality traits, as well as resistance to biotic and abiotic stresses in crops and the integration of in vitro and molecular genetic techniques in mutation induction. Topics which to be addressed at this symposium will be: Molecular genetics and biology of physical, chemical and transposon-induced mutagenesis; New mutation techniques, e.g. ion beam implantation, and their integration with other molecular and biotechnological techniques; Induced mutations in crop breeding programmes; Mutation induction for gene discovery and functional genomics, including targeting induced local lesions in genomes (TILLING) and other reverse genetic strategies; Mutational analysis of important crop characters (tolerance to abiotic stresses, resistance to diseases and insects, quality and nutritional characters, etc.); Socio-economic impact of widespread mutant varieties

Plant breeding and genetics newsletter. No. 21, July 2008

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-07-15

A major milestone for our subprogramme will be the upcoming International Symposium on Induced Mutations in Plants, which will be held 12-15 August 2008 in Vienna, Austria. This will be the eighth in the Joint FAO/IAEA Programme?s Symposium series dedicated exclusively to harnessing and disseminating information on current trends in induced mutagenesis in plants, the first of which was held in 1969 and the most recent in 1995. These previous symposia dealt with themes relating to the development of efficient protocols for induced mutagenesis and their role in the enhancement of quality traits, as well as resistance to biotic and abiotic stresses in crops and the integration of in vitro and molecular genetic techniques in mutation induction. Topics which to be addressed at this symposium will be: Molecular genetics and biology of physical, chemical and transposon-induced mutagenesis; New mutation techniques, e.g. ion beam implantation, and their integration with other molecular and biotechnological techniques; Induced mutations in crop breeding programmes; Mutation induction for gene discovery and functional genomics, including targeting induced local lesions in genomes (TILLING) and other reverse genetic strategies; Mutational analysis of important crop characters (tolerance to abiotic stresses, resistance to diseases and insects, quality and nutritional characters, etc.); Socio-economic impact of widespread mutant varieties.

Signal trend identification with fuzzy methods

International Nuclear Information System (INIS)

Reifman, J.; Tsoukalas, L. H.; Wang, X.; Wei, T. Y. C.

1999-01-01

A fuzzy-logic-based methodology for on-line signal trend identification is introduced. Although signal trend identification is complicated by the presence of noise, fuzzy logic can help capture important features of on-line signals and classify incoming power plant signals into increasing, decreasing and steady-state trend categories. In order to verify the methodology, a code named PROTREN is developed and tested using plant data. The results indicate that the code is capable of detecting transients accurately, identifying trends reliably, and not misinterpreting a steady-state signal as a transient one

The Social Influences on the Realization of Genetic Potential for Intellectual Development.

Science.gov (United States)

Guo, Guang; Stearns, Elizabeth

2002-01-01

Hypothesizes that a child's realization of genetic potential for intellectual development depends on socioeconomic environment. Peabody Picture Vocabulary Test results were examined for a large sibling sample of African American and White adolescents from the National Longitudinal Study of Adolescent Health. When SES factors were considered…

Prediction Model of Machining Failure Trend Based on Large Data Analysis

Science.gov (United States)

Li, Jirong

2017-12-01

The mechanical processing has high complexity, strong coupling, a lot of control factors in the machining process, it is prone to failure, in order to improve the accuracy of fault detection of large mechanical equipment, research on fault trend prediction requires machining, machining fault trend prediction model based on fault data. The characteristics of data processing using genetic algorithm K mean clustering for machining, machining feature extraction which reflects the correlation dimension of fault, spectrum characteristics analysis of abnormal vibration of complex mechanical parts processing process, the extraction method of the abnormal vibration of complex mechanical parts processing process of multi-component spectral decomposition and empirical mode decomposition Hilbert based on feature extraction and the decomposition results, in order to establish the intelligent expert system for the data base, combined with large data analysis method to realize the machining of the Fault trend prediction. The simulation results show that this method of fault trend prediction of mechanical machining accuracy is better, the fault in the mechanical process accurate judgment ability, it has good application value analysis and fault diagnosis in the machining process.

Wastewater management and Marcellus Shale gas development: trends, drivers, and planning implications.

Science.gov (United States)

Rahm, Brian G; Bates, Josephine T; Bertoia, Lara R; Galford, Amy E; Yoxtheimer, David A; Riha, Susan J

2013-05-15

Extraction of natural gas from tight shale formations has been made possible by recent technological advances, including hydraulic fracturing with horizontal drilling. Global shale gas development is seen as a potential energy and geopolitical "game-changer." However, widespread concern exists with respect to possible environmental consequences of this development, particularly impacts on water resources. In the United States, where the most shale gas extraction has occurred, the Marcellus Shale is now the largest natural gas producing play. To date, over 6,000,000 m(3) of wastewater has been generated in the process of extracting natural gas from this shale in the state of Pennsylvania (PA) alone. Here we examine wastewater management practices and trends for this shale play through analysis of industry-reported, publicly available data collected from the Pennsylvania Department of Environmental Protection Oil and Gas Reporting Website. We also analyze the tracking and transport of shale gas liquid waste streams originating in PA using a combination of web-based and GIS approaches. From 2008 to 2011 wastewater reuse increased, POTW use decreased, and data tracking became more complete, while the average distance traveled by wastewater decreased by over 30%. Likely factors influencing these trends include state regulations and policies, along with low natural gas prices. Regional differences in wastewater management are influenced by industrial treatment capacity, as well as proximity to injection disposal capacity. Using lessons from the Marcellus Shale, we suggest that nations, states, and regulatory agencies facing new unconventional shale development recognize that pace and scale of well drilling leads to commensurate wastewater management challenges. We also suggest they implement wastewater reporting and tracking systems, articulate a policy for adapting management to evolving data and development patterns, assess local and regional wastewater treatment

Impact of accelerated plant growth on seed variety development

Science.gov (United States)

Christophersen, Eric

1998-01-01

The commercial lives of agricultural seed products have steadily declined in recent years. The introduction of genetically engineered crop seeds in 1966 has accentuated that trend. Widespread grower demand for genetically engineered seed requires competitive response by industry followers in order to avert market share losses to the industry leaders. Limitations on plant transformation technology, regulatory requirements and patent impediments require companies to rapidly convert transformed lines into elite commercial products. Massive multigenerational backcrossing efforts are required to distribute genetically engineered traits into a broad product mix. Significant incidents of expression failures, or ``gene silencing,'' have occurred unexpectedly, requiring product substitution strategies. First-to-market strategies, competitive response, broad germplasm conversion and rescue of product failures all share the element of urgency. Technologies which reliably accelerate product development rates can expect favorable reception by commercial seed developers. A growth chamber which dramatically accelerates the rate of plant growth is described.

Bilingual Cancer Genetic Education Modules for the Deaf Community: Development and Evaluation of the Online Video Material.

Science.gov (United States)

Boudreault, Patrick; Wolfson, Alicia; Berman, Barbara; Venne, Vickie L; Sinsheimer, Janet S; Palmer, Christina

2018-04-01

Health information about inherited forms of cancer and the role of family history in cancer risk for the American Sign Language (ASL) Deaf community, a linguistic and cultural community, needs improvement. Cancer genetic education materials available in English print format are not accessible for many sign language users because English is not their native or primary language. Per Center for Disease Control and Prevention recommendations, the level of literacy for printed health education materials should not be higher than 6th grade level (~ 11 to 12 years old), and even with this recommendation, printed materials are still not accessible to sign language users or other nonnative English speakers. Genetic counseling is becoming an integral part of healthcare, but often ASL users are not considered when health education materials are developed. As a result, there are few genetic counseling materials available in ASL. Online tools such as video and closed captioning offer opportunities for educators and genetic counselors to provide digital access to genetic information in ASL to the Deaf community. The Deaf Genetics Project team used a bilingual approach to develop a 37-min interactive Cancer Genetics Education Module (CGEM) video in ASL with closed captions and quizzes, and demonstrated that this approach resulted in greater cancer genetic knowledge and increased intentions to obtain counseling or testing, compared to standard English text information (Palmer et al., Disability and Health Journal, 10(1):23-32, 2017). Though visually enhanced educational materials have been developed for sign language users with multimodal/lingual approach, little is known about design features that can accommodate a diverse audience of sign language users so the material is engaging to a wide audience. The main objectives of this paper are to describe the development of the CGEM and to determine if viewer demographic characteristics are associated with two measurable aspects of

Considering genetic characteristics in German Holstein breeding programs.

Science.gov (United States)

Segelke, D; Täubert, H; Reinhardt, F; Thaller, G

2016-01-01

Recently, several research groups have demonstrated that several haplotypes may cause embryonic loss in the homozygous state. Up to now, carriers of genetic disorders were often excluded from mating, resulting in a decrease of genetic gain and a reduced number of sires available for the breeding program. Ongoing research is very likely to identify additional genetic defects causing embryonic loss and calf mortality by genotyping a large proportion of the female cattle population and sequencing key ancestors. Hence, a clear demand is present to develop a method combining selection against recessive defects (e.g., Holstein haplotypes HH1-HH5) with selection for economically beneficial traits (e.g., polled) for mating decisions. Our proposed method is a genetic index that accounts for the allele frequencies in the population and the economic value of the genetic characteristic without excluding carriers from breeding schemes. Fertility phenotypes from routine genetic evaluations were used to determine the economic value per embryo lost. Previous research has shown that embryo loss caused by HH1 and HH2 occurs later than the loss for HH3, HH4, and HH5. Therefore, an economic value of € 97 was used against HH1 and HH2 and € 70 against HH3, HH4, and HH5. For polled, € 7 per polled calf was considered. Minor allele frequencies of the defects ranged between 0.8 and 3.3%. The polled allele has a frequency of 4.1% in the German Holstein population. A genomic breeding program was simulated to study the effect of changing the selection criteria from assortative mating based on breeding values to selecting the females using the genetic index. Selection for a genetic index on the female path is a useful method to control the allele frequencies by reducing undesirable alleles and simultaneously increasing economical beneficial characteristics maintaining most of the genetic gain in production and functional traits. Additionally, we applied the genetic index to real data and

New trends on obesity and NAFLD in Asia.

Science.gov (United States)

Fan, Jian-Gao; Kim, Seung-Up; Wong, Vincent Wai-Sun

2017-10-01

Traditionally, obesity and its related diseases have been considered a problem in Western countries. However, in the past two decades, urbanisation in many Asian countries has led to a sedentary lifestyle and overnutrition, setting the stage for the epidemic of obesity. This article reviews the epidemiological trend of obesity in Asia, with special emphasis on the emerging condition of non-alcoholic fatty liver disease (NAFLD). Currently, the population prevalence of NAFLD in Asia is around 25%, like many Western countries. While hepatocellular carcinoma and end-stage liver disease secondary to NAFLD remain uncommon, a rising trend has emerged. Around 8-19% of Asians with body mass indexes less than 25kg/m 2 are also found to have NAFLD, a condition often described as "lean" or "non-obese" NAFLD. Although this condition is generally less severe than that in more obese patients, steatohepatitis and fibrotic disease are well recognized. Central adiposity, insulin resistance and weight gain are major risk factors, and genetic predisposition, such as the PNPLA3 polymorphism appears to be more important in the development of NAFLD in the non-obese population. Lifestyle modification remains the cornerstone of management for obesity and NAFLD, but few patients can achieve adequate weight reduction and even fewer can maintain the weight in the long run. While pharmacological agents have entered phase III development for steatohepatitis, Asian patients are under-represented in most drug trials. Future studies should define the optimal management of obesity and NAFLD in Asia. Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010.

Science.gov (United States)

Sako, Eric; Famenini, Shannon; Wu, Jashin J

2016-01-01

Research investigating psoriasis has spanned decades, and as our understanding of the disease has evolved, the focus of publications has changed. We sought to characterize the trends in original psoriasis-related research from 1960 to 2010 chronologically by decade. A literature review was performed using the keyword psoriasis in the MEDLINE database. All original psoriasis-related articles published at the beginning of each decade were searched and categorized by study type and topic. Number of articles per topic. A total of 869 original psoriasis-related articles were found. The number of publications increased 18 fold over 5 decades. The immunology and pathogenesis of psoriasis was the most frequently researched topic (36%), and retrospective studies were the most common study type (37%). Recent highly published topics included biologic therapy, genetics, and psoriasis-associated cardiovascular disease. Original psoriasis-related publications have grown substantially since 1960. Basic science research into the immunology and pathogenesis has been and continues to be the mainstay of psoriasis research. Recent research trends suggest the focus has expanded to topics such as psoriasis-associated cardiovascular disease, genetics, and biologic therapy.

Trends and developments in industrial machine vision: 2013

Science.gov (United States)

Niel, Kurt; Heinzl, Christoph

2014-03-01

When following current advancements and implementations in the field of machine vision there seems to be no borders for future developments: Calculating power constantly increases, and new ideas are spreading and previously challenging approaches are introduced in to mass market. Within the past decades these advances have had dramatic impacts on our lives. Consumer electronics, e.g. computers or telephones, which once occupied large volumes, now fit in the palm of a hand. To note just a few examples e.g. face recognition was adopted by the consumer market, 3D capturing became cheap, due to the huge community SW-coding got easier using sophisticated development platforms. However, still there is a remaining gap between consumer and industrial applications. While the first ones have to be entertaining, the second have to be reliable. Recent studies (e.g. VDMA [1], Germany) show a moderately increasing market for machine vision in industry. Asking industry regarding their needs the main challenges for industrial machine vision are simple usage and reliability for the process, quick support, full automation, self/easy adjustment at changing process parameters, "forget it in the line". Furthermore a big challenge is to support quality control: Nowadays the operator has to accurately define the tested features for checking the probes. There is an upcoming development also to let automated machine vision applications find out essential parameters in a more abstract level (top down). In this work we focus on three current and future topics for industrial machine vision: Metrology supporting automation, quality control (inline/atline/offline) as well as visualization and analysis of datasets with steadily growing sizes. Finally the general trend of the pixel orientated towards object orientated evaluation is addressed. We do not directly address the field of robotics taking advances from machine vision. This is actually a fast changing area which is worth an own

Genetic variation in lipid desaturases and its impact on the development of human disease.

Science.gov (United States)

Merino, Diana M; Ma, David W L; Mutch, David M

2010-06-18

Perturbations in lipid metabolism characterize many of the chronic diseases currently plaguing our society, such as obesity, diabetes, and cardiovascular disease. Thus interventions that target plasma lipid levels remain a primary goal to manage these diseases. The determinants of plasma lipid levels are multi-factorial, consisting of both genetic and lifestyle components. Recent evidence indicates that fatty acid desaturases have an important role in defining plasma and tissue lipid profiles. This review will highlight the current state-of-knowledge regarding three desaturases (Scd-1, Fads1 and Fads2) and their potential roles in disease onset and development. Although research in rodent models has provided invaluable insight into the regulation and functions of these desaturases, the extent to which murine research can be translated to humans remains unclear. Evidence emerging from human-based research demonstrates that genetic variation in human desaturase genes affects enzyme activity and, consequently, disease risk factors. Moreover, this genetic variation may have a trans-generational effect via breastfeeding. Therefore inter-individual variation in desaturase function is attributed to both genetic and lifestyle components. As such, population-based research regarding the role of desaturases on disease risk is challenged by this complex gene-lifestyle paradigm. Unravelling the contribution of each component is paramount for understanding the inter-individual variation that exists in plasma lipid profiles, and will provide crucial information to develop personalized strategies to improve health management.

Regional Trends in Electromobility - Regional Study North America

OpenAIRE

Turrentine, Tom; Garas, Dhalia

2015-01-01

The subproject “Regional Trends in Electro mobility” aims at identifying and analyzing major trends in the field of electro mobility. The trend analysis will monitor research effort and upcoming technologies, policies, products and market developments in different focus regions around the world continuously to enable a systematic analysis of global trends. The regional trend analysis for electro mobility is a major keystone for the project success and therefore cooperation with...

Current trends in nursing theories.

Science.gov (United States)

Im, Eun-Ok; Chang, Sun Ju

2012-06-01

To explore current trends in nursing theories through an integrated literature review. The literature related to nursing theories during the past 10 years was searched through multiple databases and reviewed to determine themes reflecting current trends in nursing theories. The trends can be categorized into six themes: (a) foci on specifics; (b) coexistence of various types of theories; (c) close links to research; (d) international collaborative works; (e) integration to practice; and (f) selective evolution. We need to make our continuous efforts to link research and practice to theories, to identify specifics of our theories, to develop diverse types of theories, and to conduct international collaborative works. Our paper gives implications for future theoretical development in diverse clinical areas of nursing research and practice. © 2012 Sigma Theta Tau International.

Poor trends - The pace of poverty reduction after the Millennium Development Agenda

NARCIS (Netherlands)

Bluhm, R; de Crombrugghe, D.P.I.; Szirmai, A.

2014-01-01

We review the origins of the dollar-a-day poverty line, discuss historical poverty and inequality trends, and forecast poverty rates until 2030 using a new fractional response approach. Three findings stand out. First, global poverty reduction since 1981 has been rapid but regional trends are

A risk-based classification scheme for genetically modified foods. I: Conceptual development.

Science.gov (United States)

Chao, Eunice; Krewski, Daniel

2008-12-01

The predominant paradigm for the premarket assessment of genetically modified (GM) foods reflects heightened public concern by focusing on foods modified by recombinant deoxyribonucleic acid (rDNA) techniques, while foods modified by other methods of genetic modification are generally not assessed for safety. To determine whether a GM product requires less or more regulatory oversight and testing, we developed and evaluated a risk-based classification scheme (RBCS) for crop-derived GM foods. The results of this research are presented in three papers. This paper describes the conceptual development of the proposed RBCS that focuses on two categories of adverse health effects: (1) toxic and antinutritional effects, and (2) allergenic effects. The factors that may affect the level of potential health risks of GM foods are identified. For each factor identified, criteria for differentiating health risk potential are developed. The extent to which a GM food satisfies applicable criteria for each factor is rated separately. A concern level for each category of health effects is then determined by aggregating the ratings for the factors using predetermined aggregation rules. An overview of the proposed scheme is presented, as well as the application of the scheme to a hypothetical GM food.

Process of liquid radioactive waste treatment in nuclear power plant and development trend

International Nuclear Information System (INIS)

Liu Jiean; Wang Xin; Liu Dan; Zhu Laiye; Chen Bin

2014-01-01

The popular liquid radioactive waste treatment methods in nuclear power plants (NPP) are Chemical precipitation, evaporation, ion exchange, membrane treatment, chemical coagulation and activated carbon absorption and so on. 'Filter + activated carbon absorption (Chemical coagulation) + ion exchange' has a good prospect for development, as its simple process, high decontamination factor, low energy consumption and smaller secondary wastes. Also the process is used in Sanmen and Haiyang Projects. The severe incident in NPP set an even higher demand on liquid radioactive waste treatment. The new type treatment materials, optimization of the existed treatment, combination of treatment and the mobile treatment facility is the development trend in liquid radioactive waste treatment in NPP. (authors)

Trends in the Development of International Tourism and Imperatives of Modernizing the Tourism Industry

Directory of Open Access Journals (Sweden)

Zeyneb Adamanova

2015-01-01

Full Text Available This article provides a rationale for the significance and explores the characteristics of international tourism. The author establishes that this sector of the global economy has been developing in quite a sustainable fashion, without being affected by substantial differences between various regions around the world. The author discusses groups of stimulating factors and major trends in the development of international tourism at the current stage, including major changes in the tourism product and the operation of the global market of tourism services. The article defines the imperatives of modernizing the tourism industry at the national level.

[Internal migration trends and regional dynamics].

Science.gov (United States)

Trabelsi, M

1992-01-01

This study concerns aspects of regional development in Tunisia. It specifically considers how economic factors affect income differentials among regions, and ways in which these in turn influence trends in internal migration. The effect of these trends on urbanization is also explored.

Emotional voice processing: investigating the role of genetic variation in the serotonin transporter across development.

Directory of Open Access Journals (Sweden)

Tobias Grossmann

Full Text Available The ability to effectively respond to emotional information carried in the human voice plays a pivotal role for social interactions. We examined how genetic factors, especially the serotonin transporter genetic variation (5-HTTLPR, affect the neurodynamics of emotional voice processing in infants and adults by measuring event-related brain potentials (ERPs. The results revealed that infants distinguish between emotions during an early perceptual processing stage, whereas adults recognize and evaluate the meaning of emotions during later semantic processing stages. While infants do discriminate between emotions, only in adults was genetic variation associated with neurophysiological differences in how positive and negative emotions are processed in the brain. This suggests that genetic association with neurocognitive functions emerges during development, emphasizing the role that variation in serotonin plays in the maturation of brain systems involved in emotion recognition.

Underground coal mining - methods, equipment developments and trends

Energy Technology Data Exchange (ETDEWEB)

Singhal, R

1988-12-01

Underground mines are truly beginning to accept the so-called 'high tech' technology evident in other industries. Automation, remote control and robotics have taken an added significance. Wireless communication, mine-wide equipment health and performance monitoring, and transmission of data from deeper levels to surface is moving towards becoming the norm. There is emphasis on developing and applying continuous mining systems, as well as on modifying cyclical discontinuous methods to continuous systems. Multi-purpose equipment is also being developed. Technology transfer is playing its role - equipment and systems from surface coal mining are being applied to underground mining and vice-versa. At the American Mining Congress Exhibition held in Chicago in April 1988, a variety of equipment for underground mining was displayed including coal face equipment such as shearer loaders, conveyors and powered supports, and equipment for room-and-pillar coal mining. The trend continues to be towards high power machines equipped with a variety of electronics and sensors, safety devices, and alarm systems. Ancillary equipment on display covered a variety of cutting drums, cutting tools, conveying equipment and so on. In room-and-pillar mining, the overall emphasis was on moving away from the cyclical nature of the work. Transportation by shuttle cars must be replaced by continuous transport systems such as conveyors. Experience from Australia has shown that the application of continuous haulage and breaker line supports has permitted a doubling of production from room-and-pillar systems. Production levels of 3,000tpd have already been achieved, and 4,000tpd is considered achievable.

Surface crack testing - state of technique and trends in development

International Nuclear Information System (INIS)

1991-01-01

This Seminar contains 12 lectures on the following subjects: State of technique in magnetic powder testing (K. Goebbels); Recognisability of faults and probability of faults in surface crack testing (W. Morgner); Requirements for picture processing systems for proving and assessing crack indications (M. Stadthaus); Possibilities and limits of automatic crack recognition in magnetic powder testing (V. Deutsch); Development of equipment for eddy current testing (M. Junger); Signal processing - a way of improving the recognisability of faults in eddy current testing (R. Becker); Methods of testing steel products for surface faults and their practical limits of fault recognisability (D. Thiery); Surface crack testing in pipe manufacture (R. Pawelletz); Surface crack testing in powerstation construction (L. v. Bernus); Trends in automation in surface crack testing (G. Maier); Eddy current testing in engine construction (E. Dickhaut); Eddy current testing in aircraft repair (F. Schur). (orig.) [de

The filamentous fungus Sordaria macrospora as a genetic model to study fruiting body development.

Science.gov (United States)

Teichert, Ines; Nowrousian, Minou; Pöggeler, Stefanie; Kück, Ulrich

2014-01-01

Filamentous fungi are excellent experimental systems due to their short life cycles as well as easy and safe manipulation in the laboratory. They form three-dimensional structures with numerous different cell types and have a long tradition as genetic model organisms used to unravel basic mechanisms underlying eukaryotic cell differentiation. The filamentous ascomycete Sordaria macrospora is a model system for sexual fruiting body (perithecia) formation. S. macrospora is homothallic, i.e., self-fertile, easily genetically tractable, and well suited for large-scale genomics, transcriptomics, and proteomics studies. Specific features of its life cycle and the availability of a developmental mutant library make it an excellent system for studying cellular differentiation at the molecular level. In this review, we focus on recent developments in identifying gene and protein regulatory networks governing perithecia formation. A number of tools have been developed to genetically analyze developmental mutants and dissect transcriptional profiles at different developmental stages. Protein interaction studies allowed us to identify a highly conserved eukaryotic multisubunit protein complex, the striatin-interacting phosphatase and kinase complex and its role in sexual development. We have further identified a number of proteins involved in chromatin remodeling and transcriptional regulation of fruiting body development. Furthermore, we review the involvement of metabolic processes from both primary and secondary metabolism, and the role of nutrient recycling by autophagy in perithecia formation. Our research has uncovered numerous players regulating multicellular development in S. macrospora. Future research will focus on mechanistically understanding how these players are orchestrated in this fungal model system. Copyright © 2014 Elsevier Inc. All rights reserved.

The trend of the research and development for the upgrade of the high current energy system

International Nuclear Information System (INIS)

2010-01-01

The high current energy technology ranges from a basic technology of the electric power field to a state-of-the-art technology and has been used extremely variously. In addition, as the energy technology advances, the expansion of applied field, such as the nuclear fusion and the exhaust thing processing, etc., requires a further upgrade of the large current technology. In this report, the trend of the research and development for the upgrade of the high current energy technology are summarized. In the following, the elemental technology including arc/plasma phenomena and the pulse power system is described in Chapter 2. In Chapter 3, the trend of the research and development for the upgrade of various equipments and devices such as the nuclear fusion development, the superconducting applications of SMES and the maglev transportation system, and the arc application of the exhaust processing for a medical waste, the radio active waste and a detrimental gas and the next generation lithography system. In Chapter 4, the analysis and the measurement technology of the arc phenomenon and the standardization of current shunt, etc are described. We hope this research report can contribute to the promotion of technical exchanges in different fields, and offer guidelines for future development in this high current energy technology. (author)

Continuity of Genetic and Environmental Influences on Cognition across the Life Span: A Meta-Analysis of Longitudinal Twin and Adoption Studies

Science.gov (United States)

Tucker-Drob, Elliot M.; Briley, Daniel A.

2014-01-01

The longitudinal rank-order stability of cognitive ability increases dramatically over the lifespan. Multiple theoretical perspectives have proposed that genetic and/or environmental mechanisms underlie the longitudinal stability of cognition, and developmental trends therein. However, the patterns of stability of genetic and environmental influences on cognition over the lifespan largely remain poorly understood. We searched for longitudinal studies of cognition that reported raw genetically-informative longitudinal correlations or parameter estimates from longitudinal behavior genetic models. We identified 150 combinations of time points and measures from 15 independent longitudinal samples. In total, longitudinal data came from 4,538 monozygotic twin pairs raised together, 7,777 dizygotic twin pairs raised together, 34 monozygotic twin pairs raised apart, 78 dizygotic twin pairs raised apart, 141 adoptive sibling pairs, and 143 non-adoptive sibling pairs, ranging in age from infancy through late adulthood. At all ages, cross-time genetic correlations and shared environmental correlations were substantially larger than cross-time nonshared environmental correlations. Cross-time correlations for genetic and shared environmental components were low during early childhood, increased sharply over child development, and remained relatively high from adolescence through late adulthood. Cross-time correlations for nonshared environmental components were low across childhood and increased gradually to moderate magnitudes in adulthood. Increasing phenotypic stability over child development was almost entirely mediated by genetic factors. Time-based decay of genetic and shared environmental stability was more pronounced earlier in child development. Results are interpreted in reference to theories of gene-environment interaction and correlation. PMID:24611582

Population and trends in the global mean temperature

NARCIS (Netherlands)

Tol, Richard S.J.

2017-01-01

The Fisher ideal index, developed to measure price inflation, is applied to define a population-weighted temperature trend. This method has the advantages that the trend is representative for the population distribution throughout the sample but without conflating the trend in the population

Genetic diversity of the Japanese wood pigeon, Columba janthina, endemic to islands of East Asia, estimated by newly developed microsatellite markers.

Science.gov (United States)

Ando, Haruko; Kaneko, Shingo; Suzuki, Hajime; Horikoshi, Kazuo; Takano, Hajime; Ogawa, Hiroko; Isagi, Yuji

2011-12-01

The Japanese wood pigeon Columba janthina is endemic to islands of East Asia and is listed as Near Threatened by the International Union for Conservation of Nature (IUCN). One subspecies, C. janthina nitens, in particular, is at the greatest risk of extinction due to its small population size. To reduce the extinction risk of C. janthina, it is important to understand the species' present genetic status and to develop an appropriate conservation plan based on genetic data. We developed seven new microsatellite markers for two subspecies of C. janthina: C. janthina janthina and C. janthina nitens. We also confirmed the cross-use of one microsatellite marker developed for Columba livia var. domestica. Seven loci were polymorphic in C. janthina janthina, while two loci were polymorphic in C. janthina nitens. Using the markers, we performed preliminary analysis of genetic diversity and genetic structure within each subspecies. The expected heterozygosity ranged from 0.00 to 0.64 in C. janthina janthina and from 0.00 to 0.08 in C. janthina nitens. Each subspecies and each population within C. janthina janthina had different allele frequencies. C. janthina nitens exhibited far lower genetic diversity than C. janthina janthina. Furthermore, C. janthina nitens appears to have experienced strong genetic drift from a common ancestral population, inferred by STRUCTURE analysis. The markers described here may be useful for investigating genetic diversity and genetic structure of C. janthina populations, and could be used to estimate appropriate evolutionary significant unit and to guide development of a captive breeding program based on genetic information.

Assessing the Molecular Genetics of the Development of Executive Attention in Children: Focus on Genetic Pathways Related to the Anterior Cingulate Cortex and Dopamine

Science.gov (United States)

Brocki, Karin; Clerkin, Suzanne M.; Guise, Kevin G.; Fan, Jin; Fossella, John A.

2009-01-01

It is well-known that children show gradual and protracted improvement in an array of behaviors involved in the conscious control of thought and emotion. Non-invasive neuroimaging in developing populations has revealed many neural correlates of behavior, particularly in the developing cingulate cortex and fronto-striatal circuits. These brain regions, themselves, undergo protracted molecular and cellular change in the first two decades of human development and, as such, are ideal regions of interest for cognitive- and imaging-genetic studies that seek to link processes at the biochemical and synaptic levels to brain activity and behavior. We review our research to-date that employs both adult and child-friendly versions of the Attention Network Task (ANT) in an effort to begin to describe the role of specific genes in the assembly of a functional attention system. Presently, we constrain our predictions for genetic association studies by focusing on the role of the anterior cingulate cortex (ACC) and of dopamine in the development of executive attention. PMID:19344637

Reverse genetics with animal viruses. NSV reverse genetics

International Nuclear Information System (INIS)

Mebatsion, T.

2005-01-01

New strategies to genetically manipulate the genomes of several important animal pathogens have been established in recent years. This article focuses on the reverse genetics techniques, which enables genetic manipulation of the genomes of non-segmented negative-sense RNA viruses. Recovery of a negative-sense RNA virus entirely from cDNA was first achieved for rabies virus in 1994. Since then, reverse genetic systems have been established for several pathogens of medical and veterinary importance. Based on the reverse genetics technique, it is now possible to design safe and more effective live attenuated vaccines against important viral agents. In addition, genetically tagged recombinant viruses can be designed to facilitate serological differentiation of vaccinated animals from infected animals. The approach of delivering protective immunogens of different pathogens using a single vector was made possible with the introduction of the reverse genetics system, and these novel broad-spectrum vaccine vectors have potential applications in improving animal health in developing countries. (author)

Molecular Population Genetics.

Science.gov (United States)

Casillas, Sònia; Barbadilla, Antonio

2017-03-01

Molecular population genetics aims to explain genetic variation and molecular evolution from population genetics principles. The field was born 50 years ago with the first measures of genetic variation in allozyme loci, continued with the nucleotide sequencing era, and is currently in the era of population genomics. During this period, molecular population genetics has been revolutionized by progress in data acquisition and theoretical developments. The conceptual elegance of the neutral theory of molecular evolution or the footprint carved by natural selection on the patterns of genetic variation are two examples of the vast number of inspiring findings of population genetics research. Since the inception of the field, Drosophila has been the prominent model species: molecular variation in populations was first described in Drosophila and most of the population genetics hypotheses were tested in Drosophila species. In this review, we describe the main concepts, methods, and landmarks of molecular population genetics, using the Drosophila model as a reference. We describe the different genetic data sets made available by advances in molecular technologies, and the theoretical developments fostered by these data. Finally, we review the results and new insights provided by the population genomics approach, and conclude by enumerating challenges and new lines of inquiry posed by increasingly large population scale sequence data. Copyright © 2017 Casillas and Barbadilla.

Solar Energy in China: Development Trends for Solar Water Heaters and Photovoltaics in the Urban Environment

Science.gov (United States)

Wallace, William; Wang, Zhongying

2006-01-01

China is the world's largest market for solar water heating systems, installing 13 million square meters of new systems in 2004, mostly in large cities. Municipal authorities, however, are sensitive to quality and visual impact issues created by this technology deployment. Therefore, there is currently a trend toward developing building integrated…

When are genetic methods useful for estimating contemporary abundance and detecting population trends?

Science.gov (United States)

David A. Tallmon; Dave Gregovich; Robin S. Waples; C. Scott Baker; Jennifer Jackson; Barbara L. Taylor; Eric Archer; Karen K. Martien; Fred W. Allendorf; Michael K. Schwartz

2010-01-01

The utility of microsatellite markers for inferring population size and trend has not been rigorously examined, even though these markers are commonly used to monitor the demography of natural populations. We assessed the ability of a linkage disequilibrium estimator of effective population size (Ne) and a simple capture-recapture estimator of abundance (N) to quantify...

[The development of molecular human genetics and its significance for perspectives of modern medicine].

Science.gov (United States)

Coutelle, C; Speer, A; Grade, K; Rosenthal, A; Hunger, H D

1989-01-01

The introduction of molecular human genetics has become a paradigma for the application of genetic engineering in medicine. The main principles of this technology are the isolation of molecular probes, their application in hybridization reactions, specific gene-amplification by the polymerase chain reaction, and DNA sequencing reactions. These methods are used for the analysis of monogenic diseases by linkage studies and the elucidation of the molecular defect causing these conditions, respectively. They are also the basis for genomic diagnosis of monogenic diseases, introduced into the health care system of the GDR by a national project on Duchenne/Becker muscular dystrophy, Cystic Fibrosis and Phenylketonuria. The rapid development of basic research on the molecular analysis of the human genome and genomic diagnosis indicates, that human molecular genetics is becoming a decisive basic discipline of modern medicine.

Crumbling Diversity: Comparison of Historical Archived and Contemporary Natural Populations Indicate Reduced Genetic Diversity and Increasing Genetic Differentiation in the Golden-Cheeked Warbler

Science.gov (United States)

2011-06-01

clavata. Heredity 101:120–126 Crow JF, Denniston C (1988) Inbreeding and variance effective population numbers. Evolution 42:482–495 Dixo M, Metzger JP...University Press, Cambridge, pp 361–366 Young A, Boyle T, Brown T (1996) The population genetic consequences of habitat fragmentation for plants . Trends

Trends and prospects of nuclear power development programs in the Asian countries

International Nuclear Information System (INIS)

Kim, Kyoung Pyo; Lee, Jeong Kong

1998-12-01

This report is intended to look into the trends and prospects of nuclear power development programs in the Asian countries which will emerge as major business markets for the international nuclear industry and will seek to strengthen nuclear cooperation with Korea. In Asia, which accounts for about half of the world's population, there are many countries which have already expanded and are ready to embark on nuclear programs to meet increasing energy demands resulting from the rapidly growing economic development in the region. The Asian region will also emerge as a new area for economic development in the 21st century. The future demand for nuclear power programs will also increase in booming Asia where rapid industrialization has been in progress. The main constraints to nuclear power deployment in Asia include fund-raising for nuclear development, weakness of technical infrastructure and so on. In this regard, these problems need to be addressed to successfully implement nuclear programs in the region. This report could be used to establish national policies for nuclear cooperation and nuclear business with Asian countries expected to develop active nuclear power programmes in the future. (author). 8 refs., 11 tabs

Trends and developments in MRI contrast agent research

International Nuclear Information System (INIS)

Cavagna, F.M.; Dapra, M.; Castelli, P.M.; Maggioni, F.; Kirchin, M.A.

1997-01-01

The currently prevailing trends in industrial contrast agent research for MRI are discussed. Specific mention is made of contrast agents for liver imaging using both static and delayed procedures, of the potential for blood pool agents and the form such agents may take, and of the ultimate challenge for contrast agent R and D: tissue-targeting in a wider sense to both normal and pathologic tissues. (orig.)

TRENDS IN THE DEVELOPMENT OF MARKETING COMMUNICATIONS IN THE GLOBAL INTERACTIVE SPACE

Directory of Open Access Journals (Sweden)

N. Kochkina

2014-09-01

Full Text Available The article identifies trends in the development of marketing communications in the global interactive space by analyzing the factors of their functioning and researching motivation of viral audience. It is revealed the prevalence of interactive technologies in today's information space and the growth dynamics of interactive advertising market. It is proved that favorable conditions for marketing communications' functioning forms the basis for the development of viral advertising as an effective communication tool for untraditional impact on potential customers. The popularity of social networks as a major source of viral messages is determined. The motivation of YouTube audience, which provides a resonant video viewing and retransmission, is investigated. Gender and age differences that stipulate communication affect on consumers are identified. Cyclic social consciousness is observed that demands further research of viral audience, including constructing scenarios of viral behavior.

Technical Developments and Trends of Earthquake Resisting High-Strength Reinforcing Steel Bars

Energy Technology Data Exchange (ETDEWEB)

Hwang, Byoungchul [Seoul National University of Science and Technology, Seoul (Korea, Republic of); Shim, Jae-Hyeok [Korea Institute of Science and Technology, Seoul (Korea, Republic of); Lee, Myoung-Gyu; Lee, Joonho [Korea University, Seoul (Korea, Republic of); Jung, Jun-Ho [Hyundai Steel, Incheon (Korea, Republic of); Kim, Bo-Sung [Daehan Steel, Busan (Korea, Republic of); Won, Sung-Bin [Dongkuk Steel, Kyungju (Korea, Republic of)

2016-12-15

Since reconstruction of old town in Korea requires high-rise and seismic design construction, many attentions have been paid to high strength seismic reinforced steel bar. In the present paper, technical developments and trends are summarized for developing next-generation seismic reinforced steel bar of grade 700 MPa. Steelmaking process requires high energy efficiency and refining ability. Effects of alloying elements are explained, and alloy design based on computational thermodynamics is introduced. On the other hand, it is considered that grain size refinement by the controlled rolling and low temperature transformation structures formed by the accelerated cooling are effective to obtain acceptable mechanical properties with high strength. Finite element simulation analysis is also useful to understand plastic deformation by rolling, internal and external heat transfer, and corresponding phase transformation of austenite phase to various low-temperature transformation structures.

Technical Developments and Trends of Earthquake Resisting High-Strength Reinforcing Steel Bars

International Nuclear Information System (INIS)

Hwang, Byoungchul; Shim, Jae-Hyeok; Lee, Myoung-Gyu; Lee, Joonho; Jung, Jun-Ho; Kim, Bo-Sung; Won, Sung-Bin

2016-01-01

Since reconstruction of old town in Korea requires high-rise and seismic design construction, many attentions have been paid to high strength seismic reinforced steel bar. In the present paper, technical developments and trends are summarized for developing next-generation seismic reinforced steel bar of grade 700 MPa. Steelmaking process requires high energy efficiency and refining ability. Effects of alloying elements are explained, and alloy design based on computational thermodynamics is introduced. On the other hand, it is considered that grain size refinement by the controlled rolling and low temperature transformation structures formed by the accelerated cooling are effective to obtain acceptable mechanical properties with high strength. Finite element simulation analysis is also useful to understand plastic deformation by rolling, internal and external heat transfer, and corresponding phase transformation of austenite phase to various low-temperature transformation structures.

Development, applications and distribution of DNA markers for genetic information for sorghum and maize improvement

International Nuclear Information System (INIS)

Lee, M.

2001-01-01

This final report summarizes the progress made towards the enhancement and distribution of genetic resources (e.g. genetic stocks, seed and DNA clones) used for basic and applied aspects of the genetic improvement of maize and sorghum. The genetic maps of maize and sorghum were improved through comparative mapping of RFLP loci detected by 124 maize cDNA clones and through the development of a new mapping population of maize. Comparative mapping between maize and sorghum and maize and rice, using the set of 124 maize cDNA clones (and other clones) in each study, substantiated previous observations of extensive conservation of locus order but it also provided strong evidence of numerous large-scale chromosomal rearrangements. The new mapping population for maize (intermated B73xMo17, 'IBM') was created by random intermating during the first segregating generation. Intermating for four generations prior to the derivation of recombinant inbred lines (RILs) increased the frequency of recombinants at many regions of the maize genome and provided better genetic resolution of locus order. Expansion of the maize genetic map was not uniform along the length of a linkage group and was less than the theoretical expectation. The 350 IBM RILs were genotyped at 512 loci detected by DNA clones, including 76 of the 124 supported by this contract. The production of the sorghum mapping population of RILs from the cross CK60xPI229828 has been delayed by weather conditions that were not conducive to plant growth and seed development. Seed of the IBM RILs have been distributed (approximately 5000 RILs in total) to 16 research organizations in the public and private sector. The DNA clones have been distributed (1,206 in total) to nine research labs. Further distribution of the seed and clones will be managed by curators at stock centers in the public domain. (author)

Recommendations for Genetic Variation Data Capture in Developing Countries to Ensure a Comprehensive Worldwide Data Collection

Science.gov (United States)

Patrinos, George P; Al Aama, Jumana; Al Aqeel, Aida; Al-Mulla, Fahd; Borg, Joseph; Devereux, Andrew; Felice, Alex E; Macrae, Finlay; Marafie, Makia J; Petersen, Michael B; Qi, Ming; Ramesar, Rajkumar S; Zlotogora, Joel; Cotton, Richard GH

2011-01-01

Developing countries have significantly contributed to the elucidation of the genetic basis of both common and rare disorders, providing an invaluable resource of cases due to large family sizes, consanguinity, and potential founder effects. Moreover, the recognized depth of genomic variation in indigenous African populations, reflecting the ancient origins of humanity on the African continent, and the effect of selection pressures on the genome, will be valuable in understanding the range of both pathological and nonpathological variations. The involvement of these populations in accurately documenting the extant genetic heterogeneity is more than essential. Developing nations are regarded as key contributors to the Human Variome Project (HVP; http://www.humanvariomeproject.org), a major effort to systematically collect mutations that contribute to or cause human disease and create a cyber infrastructure to tie databases together. However, biomedical research has not been the primary focus in these countries even though such activities are likely to produce economic and health benefits for all. Here, we propose several recommendations and guidelines to facilitate participation of developing countries in genetic variation data documentation, ensuring an accurate and comprehensive worldwide data collection. We also summarize a few well-coordinated genetic data collection initiatives that would serve as paradigms for similar projects. Hum Mutat 31:1–8, 2010. © 2010 Wiley-Liss, Inc. PMID:21089065

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

DEFF Research Database (Denmark)

Song, Yong; Schwager, Michelle J; Backer, Vibeke

2017-01-01

The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically...... separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit......-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases....

TRENDS: The aeronautical post-test database management system

Science.gov (United States)

Bjorkman, W. S.; Bondi, M. J.

1990-01-01

TRENDS, an engineering-test database operating system developed by NASA to support rotorcraft flight tests, is described. Capabilities and characteristics of the system are presented, with examples of its use in recalling and analyzing rotorcraft flight-test data from a TRENDS database. The importance of system user-friendliness in gaining users' acceptance is stressed, as is the importance of integrating supporting narrative data with numerical data in engineering-test databases. Considerations relevant to the creation and maintenance of flight-test database are discussed and TRENDS' solutions to database management problems are described. Requirements, constraints, and other considerations which led to the system's configuration are discussed and some of the lessons learned during TRENDS' development are presented. Potential applications of TRENDS to a wide range of aeronautical and other engineering tests are identified.

Global fertility and population trends.

Science.gov (United States)

Bongaarts, John

2015-01-01

Over the past several decades, the world and most countries have undergone unprecedented demographic change. The most obvious example of this change is the rise in human numbers, and there are also important trends in fertility, family structure, mortality, migration, urbanization, and population aging. This paper summarizes past trends and projections in fertility and population. After reaching 2.5 billion in 1950, the world population grew rapidly to 7.2 billion in 2013 and the projections expect this total to be 10.9 billion by 2100. World regions differ widely in their demographic trends, with rapid population growth and high fertility continuing in the poorest countries, particularly in sub-Saharan Africa, while population decline, population aging, and very low fertility are now a key concern in many developed countries. These trends have important implications for human welfare and are of interest to policy makers. The conclusion comments briefly on policy options to address these adverse trends. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Development and application of a multi-targeting reference plasmid as calibrator for analysis of five genetically modified soybean events.

Science.gov (United States)

Pi, Liqun; Li, Xiang; Cao, Yiwei; Wang, Canhua; Pan, Liangwen; Yang, Litao

2015-04-01

Reference materials are important in accurate analysis of genetically modified organism (GMO) contents in food/feeds, and development of novel reference plasmid is a new trend in the research of GMO reference materials. Herein, we constructed a novel multi-targeting plasmid, pSOY, which contained seven event-specific sequences of five GM soybeans (MON89788-5', A2704-12-3', A5547-127-3', DP356043-5', DP305423-3', A2704-12-5', and A5547-127-5') and sequence of soybean endogenous reference gene Lectin. We evaluated the specificity, limit of detection and quantification, and applicability of pSOY in both qualitative and quantitative PCR analyses. The limit of detection (LOD) was as low as 20 copies in qualitative PCR, and the limit of quantification (LOQ) in quantitative PCR was 10 copies. In quantitative real-time PCR analysis, the PCR efficiencies of all event-specific and Lectin assays were higher than 90%, and the squared regression coefficients (R(2)) were more than 0.999. The quantification bias varied from 0.21% to 19.29%, and the relative standard deviations were from 1.08% to 9.84% in simulated samples analysis. All the results demonstrated that the developed multi-targeting plasmid, pSOY, was a credible substitute of matrix reference materials, and could be used as a reliable reference calibrator in the identification and quantification of multiple GM soybean events.

Risks and benefits of genetically modified foods | Amin | African ...

African Journals Online (AJOL)

There are claims that fear towards new technology has been caused by the lack of information and education on the subject to the public. Modern biotechnology and its applications have been receiving the same criticism. Thus, the objective of this study is to analyze the trends and coverage of genetically modified food ...

Task 1.5 Genomic Shift and Drift Trends of Emerging Pathogens

Energy Technology Data Exchange (ETDEWEB)

Borucki, M

2010-01-05

The Lawrence Livermore National Laboratory (LLNL) Bioinformatics group has recently taken on a role in DTRA's Transformation Medical Technologies Initiative (TMTI). The high-level goal of TMTI is to accelerate the development of broad-spectrum countermeasures. To achieve those goals, TMTI has a near term need to conduct analyses of genomic shift and drift trends of emerging pathogens, with a focused eye on select agent pathogens, as well as antibiotic and virulence markers. Most emerging human pathogens are zoonotic viruses with a genome composed of RNA. The high mutation rate of the replication enzymes of RNA viruses contributes to sequence drift and provides one mechanism for these viruses to adapt to diverse hosts (interspecies transmission events) and cause new human and zoonotic diseases. Additionally, new viral pathogens frequently emerge due to genetic shift (recombination and segment reassortment) which allows for dramatic genotypic and phenotypic changes to occur rapidly. Bacterial pathogens also evolve via genetic drift and shift, although sequence drift generally occurs at a much slower rate for bacteria as compared to RNA viruses. However, genetic shift such as lateral gene transfer and inter- and intragenomic recombination enables bacteria to rapidly acquire new mechanisms of survival and antibiotic resistance. New technologies such as rapid whole genome sequencing of bacterial genomes, ultra-deep sequencing of RNA virus populations, metagenomic studies of environments rich in antibiotic resistance genes, and the use of microarrays for the detection and characterization of emerging pathogens provide mechanisms to address the challenges posed by the rapid emergence of pathogens. Bioinformatic algorithms that enable efficient analysis of the massive amounts of data generated by these technologies as well computational modeling of protein structures and evolutionary processes need to be developed to allow the technology to fulfill its potential.

The development of a genetic investigation centre at a maternity hospital.

Science.gov (United States)

Hockey, A

1975-08-16

The development of a centre for the investigation of genetic aspects of still birth, neonatal deaths and mental deficiency is described. It is suitably located in a maternity hospital and provides counselling early enough to prevent the brith of a subsequent affected infant in high-risk groups. A variety of laboratory and other facilities are in close proximity. This has the advantage of allowing procedures, such as amniocentesis and ultrasound examination for prenatal diagnosis, to be arranged in consultation with hospital staff members. The aetiology of the first 120 cases seen, their reason for referral, recurrence risk, and "decision made", are reported in detail elsewhere. The mode of operation with regard to source of case, appointments, staff and records is outlined fully in this paper. The conclusion to be reached is that, within two years of its inception, the genetic investigation centre is already providing a useful community service.

Analysis of gravity data using trend surfaces

Science.gov (United States)

Asimopolos, Natalia-Silvia; Asimopolos, Laurentiu

2013-04-01

In this paper we have developed algorithms and related software programs for calculating of trend surfaces of higher order. These methods of analysis of trends, like mobile media applications are filtration systems for geophysical data in surface. In particular we presented few case studies for gravity data and gravity maps. Analysis with polynomial trend surfaces contributes to the recognition, isolation and measurement of trends that can be represented by surfaces or hyper-surfaces (in several sizes), thus achieving a separation in regional variations and local variations. This separation is achieved by adjusting the trend function at different values. Trend surfaces using the regression analysis satisfy the criterion of least squares. The difference between the surface of trend and the observed value in a certain point is the residual value. Residual sum of squares of these values should be minimal as the criterion of least squares. The trend surface is considered as regional or large-scale and the residual value will be regarded as local or small-scale component. Removing the regional trend has the effect of highlighting local components represented by residual values. Surface analysis and hyper-surfaces principles are applied to the surface trend and any number of dimensions. For hyper-surfaces we can work with polynomial functions with four or more variables (three variables of space and other variables for interest parameters) that have great importance in some applications. In the paper we presented the mathematical developments about generalized trend surfaces and case studies about gravimetric data. The trend surfaces have the great advantage that the effect of regional anomalies can be expressed as analytic functions. These tendency surfaces allows subsequent mathematical processing and interesting generalizations, with great advantage to work with polynomial functions compared with the original discrete data. For gravity data we estimate the depth of

Genetic Romanticism

DEFF Research Database (Denmark)

Tupasela, Aaro

2016-01-01

inheritance as a way to unify populations within politically and geographically bounded areas. Thus, new genetics have contributed to the development of genetic romanticisms, whereby populations (human, plant, and animal) can be delineated and mobilized through scientific and medical practices to represent...

Trends in communications satellites

CERN Document Server

Curtin, Denis J

1979-01-01

Trends in Communications Satellites offers a comprehensive look at trends and advances in satellite communications, including experimental ones such as NASA satellites and those jointly developed by France and Germany. The economic aspects of communications satellites are also examined. This book consists of 16 chapters and begins with a discussion on the fundamentals of electrical communications and their application to space communications, including spacecraft, earth stations, and orbit and wavelength utilization. The next section demonstrates how successful commercial satellite communicati

Towards a genetic architecture of cryptic genetic variation and ...

Indian Academy of Sciences (India)

Unknown

reprinted in this issue as a J. Genet. classic, pages 227–257). IAN DWORKIN* ... In this commentary, I will discuss the context of this work examining the genetic ... mental buffering where development was channelled in one of several ...

Current research and development trends in floristic geography

OpenAIRE

Hang Sun; Tao Deng; Yongsheng Chen; Zhuo Zhou

2017-01-01

This paper summarizes the research status, existing issues, and trends in floristic geography. There is now a wealth of research accumulation on floristic investigations, distribution types of genera, floristic regions, and regional floristic analysis. It is also noted that most of these studies utilize simple statistical analyses, comparative studies, traditional methods, and single subjects, to provide a basic understanding and description of the floristic phenomenon, which is lacking spati...

Development of STS and CAPS markers for variety identification and genetic diversity analysis of tea germplasm in Taiwan.

Science.gov (United States)

Hu, Chih-Yi; Tsai, You-Zen; Lin, Shun-Fu

2014-12-01

Tea (Camellia sinensis) is an important economic crop in Taiwan. Particularly, two major commercial types of tea (Paochong tea and Oolong tea) which are produced in Taiwan are famous around the world, and they must be manufactured with specific cultivars. Nevertheless, many elite cultivars have been illegally introduced to foreign countries. Because of the lower cost, large amount of "Taiwan-type tea" are produced and imported to Taiwan, causing a dramatic damage in the tea industry. It is very urgent to develop the stable, fast and reliable DNA markers for fingerprinting tea cultivars in Taiwan and protecting intellectual property rights for breeders. Furthermore, genetic diversity and phylogenetic relationship evaluations of tea germplasm in Taiwan are imperative for parental selection in the cross-breeding program and avoidance of genetic vulnerability. Two STS and 37 CAPS markers derived from cytoplasmic genome and ESTs of tea have been developed in this study providing a useful tool for distinguishing all investigated germplasm. For identifying 12 prevailing tea cultivars in Taiwan, five core markers, including each one of mitochondria and chloroplast, and three nuclear markers, were developed. Based on principal coordinate analysis and cluster analysis, 55 tea germplasm in Taiwan were divided into three groups: sinensis type (C. sinensis var. sinensis), assamica type (C. sinensis var. assamica) and Taiwan wild species (C. formosensis). The result of genetic diversity analysis revealed that both sinensis (0.44) and assamica (0.41) types had higher genetic diversity than wild species (0.25). The close genetic distance between the first (Chin-Shin-Oolong) and the third (Shy-Jih-Chuen) prevailing cultivars was found, and many recently released varieties are the descents of Chin-Shin-Oolong. This implies the potential risk of genetic vulnerability for tea cultivation in Taiwan. We have successfully developed a tool for tea germplasm discrimination and genetic

Data from: Development of a Nasonia vitripennis outbred laboratory population for genetic analysis

NARCIS (Netherlands)

Zande, van de L.; Ferber, S.; Haan, de A.; Beukeboom, L.W.; Heerwaarden, van J.; Pannebakker, B.A.

2013-01-01

The parasitoid wasp genus Nasonia has rapidly become a genetic model system for developmental and evolutionary biology. The release of its genome sequence led to the development of high-resolution genomic tools, for both interspecific and intraspecific research, which has resulted in great advances

Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

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Diletta Bonciani

2012-01-01

Full Text Available Dermatitis herpetiformis (DH is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD. Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.

The development and treatment of Alzheimer’s disease: Some genetic aspects

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I. S. Preobrazhenskaya

2014-01-01

Full Text Available The paper gives an update on the occurrence and development of Alzheimer’s disease (AD, a condition manifesting itself as a steady reduction in memory. AD is common in the modern population. The reason for its higher incidence rate is the specific features of the current information sphere. Genetic factors that both directly lead to the development of AD and indirectly influence its occurrence are also imperative. At the present time, the genetic bank of mutations associated with the development of AD contains information on more than 300 different mutations. Genetic predetermination of this disease has a negative impact on prognosis and prospects for patient treatment.Patients and methods. The distribution of hereditary forms of AD in a Russian population was analyzed at the Clinic of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University. The investigation enrolled 46 patients (13 men and 33 women who met the international criteria for AD; all had its proven hereditary history. The patients' mean age was 73.7±8.3 years in the men and 73.4±8.5 in the women; the mean disease duration was 29.6±12.4 and 28.0±18.8 months, respectively. The incidence of AD was estimated depending on age, comorbidity, degree of cognitive impairments, and pattern of the disease. Its history was rated using a questionnaire. No genome mapping was carried out.Results and discussion. The patients were divided into two groups: 1 presenile AD (age at its onset less than 65 years; n=8 and 2 senile AD (age at its onset more than 65 years; n=38. There was a preponderance of patients with mild dementia in both groups; however, in the patients with senile AD, the latter was diagnosed at the stage of moderate cognitive impairments in 7.9% of cases. Comorbidity was mild in all the patients. Depression and behavioral disorders were noted in half of the patients with AD; at the same time, behavioral and emotional disorders were significantly

Genetic manipulation of Francisella tularensis

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Xhavit eZogaj

2011-01-01

Full Text Available Francisella tularensis is a facultative intracellular pathogen that causes the disease tularemia. F. tularensis subsp. tularensis causes the most severe disease in humans and has been classified as a select A agent and potential bioweapon. There is currently no vaccine approved for human use, making genetic manipulation of this organism critical to unraveling the genetic basis of pathogenesis and developing countermeasures against tularemia. The development of genetic techniques applicable to F. tularensis have lagged behind those routinely used for other bacteria, primarily due to lack of research and the restricted nature of the biocontainment required for studying this pathogen. However, in recent years, genetic techniques, such as transposon mutagenesis and targeted gene disruption, have been developed, that have had a dramatic impact on our understanding of the genetic basis of F. tularensis virulence. In this review, we describe some of the methods developed for genetic manipulation of F. tularensis.

Estimating grizzly and black bear population abundance and trend in Banff National Park using noninvasive genetic sampling.

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Michael A Sawaya

Full Text Available We evaluated the potential of two noninvasive genetic sampling methods, hair traps and bear rub surveys, to estimate population abundance and trend of grizzly (Ursus arctos and black bear (U. americanus populations in Banff National Park, Alberta, Canada. Using Huggins closed population mark-recapture models, we obtained the first precise abundance estimates for grizzly bears (N= 73.5, 95% CI = 64-94 in 2006; N= 50.4, 95% CI = 49-59 in 2008 and black bears (N= 62.6, 95% CI = 51-89 in 2006; N= 81.8, 95% CI = 72-102 in 2008 in the Bow Valley. Hair traps had high detection rates for female grizzlies, and male and female black bears, but extremely low detection rates for male grizzlies. Conversely, bear rubs had high detection rates for male and female grizzlies, but low rates for black bears. We estimated realized population growth rates, lambda, for grizzly bear males (λ= 0.93, 95% CI = 0.74-1.17 and females (λ= 0.90, 95% CI = 0.67-1.20 using Pradel open population models with three years of bear rub data. Lambda estimates are supported by abundance estimates from combined hair trap/bear rub closed population models and are consistent with a system that is likely driven by high levels of human-caused mortality. Our results suggest that bear rub surveys would provide an efficient and powerful means to inventory and monitor grizzly bear populations in the Central Canadian Rocky Mountains.

Estimating grizzly and black bear population abundance and trend in Banff National Park using noninvasive genetic sampling.

Science.gov (United States)

Sawaya, Michael A; Stetz, Jeffrey B; Clevenger, Anthony P; Gibeau, Michael L; Kalinowski, Steven T

2012-01-01

We evaluated the potential of two noninvasive genetic sampling methods, hair traps and bear rub surveys, to estimate population abundance and trend of grizzly (Ursus arctos) and black bear (U. americanus) populations in Banff National Park, Alberta, Canada. Using Huggins closed population mark-recapture models, we obtained the first precise abundance estimates for grizzly bears (N= 73.5, 95% CI = 64-94 in 2006; N= 50.4, 95% CI = 49-59 in 2008) and black bears (N= 62.6, 95% CI = 51-89 in 2006; N= 81.8, 95% CI = 72-102 in 2008) in the Bow Valley. Hair traps had high detection rates for female grizzlies, and male and female black bears, but extremely low detection rates for male grizzlies. Conversely, bear rubs had high detection rates for male and female grizzlies, but low rates for black bears. We estimated realized population growth rates, lambda, for grizzly bear males (λ= 0.93, 95% CI = 0.74-1.17) and females (λ= 0.90, 95% CI = 0.67-1.20) using Pradel open population models with three years of bear rub data. Lambda estimates are supported by abundance estimates from combined hair trap/bear rub closed population models and are consistent with a system that is likely driven by high levels of human-caused mortality. Our results suggest that bear rub surveys would provide an efficient and powerful means to inventory and monitor grizzly bear populations in the Central Canadian Rocky Mountains.

Recent and prospective population trends in Malaysia.

Science.gov (United States)

Jones, G W; Tan, P C

1985-09-01

Recent population trends in Malaysia are reviewed, with the focus on Peninsular Malaysia. Separate consideration is given to population growth between 1970 and 1980; mortality trends; period and cohort fertility trends; factors affecting fertility, including changes in age structure, nuptiality, and other socioeconomic and demographic changes; and the recent development of a pro-natalist policy involving a goal of a population of 70 million by 2050.

Functional abdominal pain in childhood: background studies and recent research trends.

Science.gov (United States)

Levy, Rona L; van Tilburg, Miranda A L

2012-01-01

The present review summarizes many of the major research trends investigated in the past five years regarding pediatric functional abdominal pain, and also summarizes the primary related findings from the authors' research program. Specific areas discussed based on work within the authors' group include familial illness patterns, genetics, traits, and mechanisms or processes related to abdominal pain. Topics covered from research published in the past five years include prevalence and cost, longitudinal follow-up, overlap with other disorders, etiology and mechanisms behind functional abdominal pain and treatment studies. It is hoped that findings from this work in abdominal pain will be interpreted as a framework for understanding the processes by which other pain phenomena and, more broadly, reactions to any physical state, can be developed and maintained in children. The present article concludes with recommendations for clinical practice and research.

ACTUAL TRENDS IN THE DEVELOPMENT OF VENTURE INVESTMENT IN RUSSIA

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K. P. Aleksandrova

2014-06-01

Full Text Available Relevance of research topic is related to the significant influence of the venture capital industry on the Russian economy. Innovative development of our country depends mainly on the effective commercialization of research and development, but the technology companies access to financial resources is a key factor in the innovation process . Venture capital plays a major role in this respect: it provides a fast and timely financial support to local entrepreneurs breakthrough ideas and enhances the competitiveness of the Russian economy as a whole. Objective - Analysis of Venture Investment in Russia , identifying issues and current trends in development. In the process, a set of methods has been applied economic and statistical analysis: methods of synthesis, comparison and analysis of economic and statistical information. In the study, it was determined that the current Russian venture market is characterized by an increase in the number of venture capital funds and private equity funds, as well as increasing their capitalization; an increasing number of companies financed, but about 90 % of all investments allocated for funding mature companies and only 10 % - for companies at the venture development stages; Central Federal District continues to firmly hold the leadership of the share of the total investment of all federal districts . Identified the following problems: lack of funding companies in the initial stages of development, infrastructure venture industry, inadequate legislation and taxation system , the problems associated with the protection and registration of intellectual property, the problem of lack of professional management, the lack of a well-functioning stock market, high-tech industries unattractive for investment.Purchase on Elibrary.ru > Buy nowDOI: http://dx.doi.org/10.12731/2070-7568-2014-3-5

A biography and bibliography: the recent trends in bioethics and medical genetics in Japan (Part II).

Science.gov (United States)

Fujiki, N

2000-01-01

At the present, we have much misunderstandings and prejudices, connected with psychological conflicts for the direct application of cloning and of prenatal diagnosis and selective abortion. So that we should have much debates among general public on further direction of these researchs, in order to study on safe-guard and public understandings. Summarinzingly, in order to educate general public in their understanding of ELSI problems, we should remove the boundaries between individuals, in professional and non-professional fields, and in developed and developing countries, and give more time for medical curriculum for medical genetics and bioethics, in order to educate general public, as well as scientific responsibility in our society. Finally, we hope these recommendations and reports will help the International Bioethics Seminars in Fuki on 2000 for the follow up study on Universial Declaration of Human Genome and Rights, with new technologies on pharmacogenomics DNA polymorphisms as well as our ethical debates on international research ethics, proposed at the International Bioethics Summit.

Expanding the Lotus japonicus reverse genetics toolbox – Development of LORE1 retrotransposon mutagenesis and artificial miRNA-mediated silencing

DEFF Research Database (Denmark)

Urbanski, Dorian Fabian

2011-01-01

. The protocols developed in the current project are now the cornerstone of a new LORE1 reverse genetics resource characterized by efficient mutant line generation and accurate mutation annotation. In parallel, artificial microRNAs (amiRNAs) were designed based on both Arabidopsis and Lotus backbones......Currently, the most common approach to studying Lotus japonicus (Lotus) genes is forward genetics in which a gene responsible for the studied phenotype is identified through map-based cloning. In reverse genetics, the activity of a gene of interest is modified to discover its mutant phenotype....... Prior to this project, the only reverse genetics resource available in Lotus was the TILLING resource. In an attempt to advance Lotus genetic studies, present study is focused on the development of two additional resources. The first is based on insertional mutagenesis and the second on harnessing post...

The Development Trend of the Non-governmental Higher Education in China

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Zhang Dewen

2013-12-01

Full Text Available In more than 30 years after China’s reform and opening to the outside world the non-governmental higher education has developed dramatically and enjoyed more and more favorable conditions, making great contributions to the popularization of higher education in China. According to the definition that “The non-governmental higher education is a major growth point for development of educational career and an important driving force in promoting educational reform”, quoting from The planning outline on the national medium and long-term educational reform and development (The Planning Outline for short issued in 2010 by China’s State Council, China has launched policies of greatly supporting the non-governmental higher education and designed the reform goals of the government as the main body of education, with the active participation of the whole society, and the mutual development of the governmental and non-governmental higher education. Soon afterwards, the nation has started the move of the non-governmental educational system, and positively explored the management of classification of profit and non-profit non-governmental educational institutions. Thus, the development of the Chinese non-governmental institutions of higher learning has been greatly influenced because of the policies and relevant practices. With the opening of the 18th national congress and the political direction mentioned in the report as “encouraging and guiding social organizations to initiate education”, the pace of development of the non-governmental institutions of higher learning will be accelerated and some new development trends will become clearer.

Research, regulation and use of genetically modified organisms in agriculture in the developing countries

International Nuclear Information System (INIS)

Sonnino, A.

2008-01-01

Greater international efforts are needed to overcome the political, legislative, economic, financial and social barriers that prevent genetic engineering and its products from fighting hunger and poverty and promoting rural development in the poorest countries [it

Investments of Banks in Securities: the Essence and Development Trends under Current Conditions

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Ekaterina Vladimirovna Mazikova

2015-12-01

Full Text Available The implementation of modern banking activities involves the realization of investments. Investment is a complex discussion economic category, characterized by a number of features. The types and forms of investment are manifold and can be transformed with account of the state of the economy and the level of development of industrial relations. The faster growth of the financial sector in the economy has stipulated the development of financial investment. Banks as financial and lending institutions actively make financial investments in securities. Banks’ investment in securities pursues a number of purposes which determine the selection of securities for investment and their quality. The article identified the targets of bank investments in securities and their development trends under current conditions on the basis of the analysis of the actual data for 2010–2014. Negative revaluation and the actual decrease in the value of corporate securities of Russian issuers reduce their commercial appeal. Banks refuse to speculate on the stock market in favor of the securities that ensure liquidity. Banks’ investments aim to purchasing securities from the Lombard List of the Bank of Russia in order to obtain loans and participate in the repo transactions. Thus, during the analyzed period, banks’ investments in securities transformed from systemically important assets that generate substantial profit into the mechanism that provides liquidity. It should be noted that a significant part of investment resources of Russian banks services the debt obligations of Russia’s Government. The article also identified a trend of banks’ increasing investment in the participation portfolios of subsidiaries and associated joint stock companies. The official data of the Central Bank of the Russian Federation (Bank of Russia [15], and the Federal State Statistics Service [14] were used as the information base for the study

Utility involvement in uranium exploration and development - a growing trend

International Nuclear Information System (INIS)

Sullivan, R.P.; Riedel, D.W.

1980-01-01

Nuclear power commitments by United States utilities at the beginning of 1979 represent 137,000 MW(e) of capacity from 147 nuclear units scheduled for operation by 1985 plus an additional 52,000 MW(e) from 48 units scheduled beyond 1985. Including the minority owners there are over 100 independent electric utilities in the United States of America with some financial commitment to these 195 nuclear power plants. United States uranium requirements to the year 2000 have been projected at 35 to 40% of the world requirements (exclusive of centrally planned economies). Also United States uranium resources represent a substantial fraction of present estimated world resources. Thus, decisions by US electric utilities regarding their financial involvement in uranium exploration and development can be expected to have a large impact on the development of the world-wide uranium industry. Unlike the situation in most countries with large commitments to nuclear power, the US government is not directly involved financially in uranium exploration and development except in a supportive role to the industry as a whole. Investment decisions by US utilities and US mining companies are based on their individual perceptions of the risks and benefits to be gained. Public attitudes towards nuclear power and public regulatory commission treatment of utility expenditures for resource development vary throughout the country. Thus, US utilities have shown a wide range of responses in formulating their uranium procurement strategies. About half the utilities with nuclear commitments are at present involved financially in uranium exploration and development. This paper traces the development of this trend and elaborates on the types of financial involvement and the factors that affect a utility's selection of its overall uranium procurement strategy

Genetic, environmental, and epigenetic factors in the development of personality disturbance.

Science.gov (United States)

Depue, Richard A

2009-01-01

A dimensional model of personality disturbance is presented that is defined by extreme values on interacting subsets of seven major personality traits. Being at the extreme has marked effects on the threshold for eliciting those traits under stimulus conditions: that is, the extent to which the environment affects the neurobiological functioning underlying the traits. To explore the nature of development of extreme values on these traits, each trait is discussed in terms of three major issues: (a) the neurobiological variables associated with the trait, (b) individual variation in this neurobiology as a function of genetic polymorphisms, and (c) the effects of environmental adversity on these neurobiological variables through the action of epigenetic processes. It is noted that gene-environment interaction appears to be dependent on two main factors: (a) both genetic and environmental variables appear to have the most profound and enduring effects when they exert their effects during early postnatal periods, times when the forebrain is undergoing exuberant experience-expectant dendritic and axonal growth; and (b) environmental effects on neurobiology are strongly modified by individual differences in "traitlike" functioning of neurobiological variables. A model of the nature of the interaction between environmental and neurobiological variables in the development of personality disturbance is presented.

Recent developments and future trends in nuclear medicine instrumentation

International Nuclear Information System (INIS)

Zaidi, H.

2006-01-01

Molecular imaging using high-resolution single-photon emission computed tomography (SPECT) and positron emission tomography (PET) has advanced elegantly and has steadily gained importance in the clinical and research arenas. Continuous efforts to integrate recent research findings for the design of different geometries and various detector technologies of SPECT and PET cameras have become the goal of both the academic community and nuclear medicine industry. As PET has recently become of more interest for clinical practice, several different design trends seem to have developed. Systems are being designed for ''low cost'' clinical applications, very high-resolution research applications (including small-animal imaging), and just about everywhere in-between. The development of dual-modality imaging systems has revolutionized the practice of nuclear medicine. The major advantage being that SPECT/PET data are intrinsically aligned to anatomical information from the X-ray computed tomography (CT), without the use of external markers or internal landmarks. On the other hand, combining PET with magnetic resonance imaging (MRI) technology is scientifically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of a prototype small animal PET scanner coupled to three multichannel photomultipliers via optical fibers, so that the PET detector can be operated within a conventional MR system. Thus, many different design paths are being pursued - which ones are likely to be the main stream of future commercial systems? It will be interesting, indeed, to see which technologies become the most popular in the future. This paper briefly summarizes state-of-the art developments in nuclear medicine instrumentation. Future prospects will also be discussed. (orig.)

MODERN TRENDS IN THE DEVELOPMENT OF THE TECHNOLOGIES FOR PRODUCTION OF DENTAL CONSTRUCTIONS.

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Tsanka Dikova

2015-12-01

Full Text Available The aim of the present paper is to make a review of the modern trends in the development of the technologies for production of dental constructions. Three are the main trends in production technologies in dentistry last 30 years: digitalization, simulation and implementation of additive technologies. The simulation occurred first and due to the computers development it underwent fast progress from the mathematical calculations and analytical analysis to the 3D modeling and visualization. Thus Computer Aided Engineering (CAE was developed, allowing dental constructions with optimal design to be produced by optimal technological regimes. The first Computer Aided Design (CAD – Computer Aided Manufacturing (CAM systems were created in 1970s as a result of the digitalization. In this mode of operation at first virtual 3D model is generated by CAD, which then is used for production of the real construction by CAM. The CAD-CAM systems allow fabrication of dental restorations which is difficult or impossible to be manufactured by conventional technologies. The development of CAD unit runs from indirect scanning of the plaster model for obtaining data for the 3D model to direct scanning of the prosthesis area. While the development of CAM unit leads to direct manufacturing of the real dental construction using subtractive or additive technologies. The future development of the CAD-CAM systems as a whole characterizes with transition from closed to open access systems, which make them more flexible. In the late 1980sthe new approach to the production of constructions appeared – by addition of material layer by layer. The additive technologies were developed. They characterize with building of one layer at a time from a powder or liquid that is bonded by means of melting, fusing or polymerization. Stereo lithography, fused deposition modeling, selective electron beam melting, laser powder forming and inkjet printing are the methods, mostly used in

Role of Genetic and Environmental Factors in the Development of Empathy

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Yudina T.O.,

2017-08-01

Full Text Available The paper provides a review of studies on factors influencing empathy development in early childhood and on conditions promoting manifestation of empathy in children later in life. The outcomes of several studies shed light on the character of empathic response at early stages of child development, particularly in infancy and toddlerhood. This review covers research on the role of biological factors and mechanisms in empathy development (for instance, features of temperament and neuronal bases, as well as research on the relationship between genetic and environmental factors in the development of empathy in ontogenesis. Another part of the paper describes studies on the role of social conditions in the development of empathy in childhood: it focuses primarily on family relations and, in particular, on the mother/child relationship. The paper concludes with several suggestions concerning further research of the specified problem.

Urban Land Use Planning Trend and Sustainable Challenges in Socio-Economic Development

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Muhammad Yousif Mangi

2018-04-01

Full Text Available Land use planning is a technical approach for developing and managing the land into various public interests to endorse sustainable socio-economic development. This paper focuses on socio-economic problems by improper allocations of urban land uses particularly in vertical development (High rise buildings. Taluka Qasimabad Town was selected as a case study to observe the existing urban land use trends. Spatial and Quantitative data were collected through detailed land use survey and formal interviews. The ArcGIS and SPSS (Statistical Package for Social Science online software were used to analyze spatial and quantitative data. LRM (Linear Regression Model was used for predicting urban land use change particularly in vertical development by the year 2050. In this context, yearly code and land use change variables were applied in LRM to predict land use change since 2007. The results were found that rapid change in land uses occurred in the study area, by which inhabitants are facing problems like privacy, insecurity, property devaluation, and orientation nearby their accommodations. This research can lead to suggest several ways to improve and enhance urban land use planning approaches for betterment of urban communities.

NATO International Conference on Applied General Systems Research : Recent Developments and Trends

CERN Document Server

1978-01-01

This volume consists of a selection of papers presented at the International Conference on Applied General Systems Research: Recent Developments and Trends which was held on the campus of the State University of New York at Binghamton in August 15-19, 1977, under the sponsorship of the Special Panel on Systems Science of the NATO Scientific Affairs Division. General systems research is a fairly new field which has been developing in the course of the last two or three decades. In my op~n10n, it can be best described as a movement which involves the study of all structural and context independent aspects of problem solving. As such, it is cross-disciplinary in nature and, in this sense, it might seem similar to mathematics. There is a consid­ erable difference, however, between the two. While pure mathe­ matics is basically oriented to the development of various axiomatic theories, regardless of whether or not they have any real world meaning, applied mathematics explores the applicability of some of these t...

Risk perception after genetic counseling in patients with increased risk of cancer

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Rantala Johanna

2009-08-01

population. Difference in risk perception for children/siblings as for the general population was significant between the first and second measurement time points. Anxiety about developing cancer again among affected participants continued to be high throughout this investigation. Conclusion The participant's accuracy in risk perception was poor, especially in low risk individuals before genetic counseling. There was a general trend towards more accurate estimation in all risk groups after genetic counseling. The importance of preventive programs was well understood. Cancer anxiety was prevalent and associated with risk perception, but decreased after genetic counseling. 1 National Society of Genetic Counselors (2005, Genetic Counseling as a Profession. Available at http://www.nsgc.org/about/definition.cfm (accessed November 25th 2007 2 Julian-Reynier C., Welkenhuysen M-, Hagoel L., Decruyenaere M., Hopwood P. (2003 Risk communication strategies: state of the art and effectiveness in the context of cancer genetic services. Eur J of Human Genetics 11, 725–736.

High-density SNP assay development for genetic analysis in maritime pine (Pinus pinaster).

Science.gov (United States)

Plomion, C; Bartholomé, J; Lesur, I; Boury, C; Rodríguez-Quilón, I; Lagraulet, H; Ehrenmann, F; Bouffier, L; Gion, J M; Grivet, D; de Miguel, M; de María, N; Cervera, M T; Bagnoli, F; Isik, F; Vendramin, G G; González-Martínez, S C

2016-03-01

Maritime pine provides essential ecosystem services in the south-western Mediterranean basin, where it covers around 4 million ha. Its scattered distribution over a range of environmental conditions makes it an ideal forest tree species for studies of local adaptation and evolutionary responses to climatic change. Highly multiplexed single nucleotide polymorphism (SNP) genotyping arrays are increasingly used to study genetic variation in living organisms and for practical applications in plant and animal breeding and genetic resource conservation. We developed a 9k Illumina Infinium SNP array and genotyped maritime pine trees from (i) a three-generation inbred (F2) pedigree, (ii) the French breeding population and (iii) natural populations from Portugal and the French Atlantic coast. A large proportion of the exploitable SNPs (2052/8410, i.e. 24.4%) segregated in the mapping population and could be mapped, providing the densest ever gene-based linkage map for this species. Based on 5016 SNPs, natural and breeding populations from the French gene pool exhibited similar level of genetic diversity. Population genetics and structure analyses based on 3981 SNP markers common to the Portuguese and French gene pools revealed high levels of differentiation, leading to the identification of a set of highly differentiated SNPs that could be used for seed provenance certification. Finally, we discuss how the validated SNPs could facilitate the identification of ecologically and economically relevant genes in this species, improving our understanding of the demography and selective forces shaping its natural genetic diversity, and providing support for new breeding strategies. © 2015 John Wiley & Sons Ltd.

Research of the structure and trends in the development of the logistics market in Ukraine

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Olena Karpenko

2017-12-01

Full Text Available The purpose of the article is to study the structure and capacity of the Ukrainian logistics market. Based on the use of statistical methods, mathematical modeling, forecasting, the main development trends of the market of logistics services in Ukraine are determined. The research results can be used both in scientific sphere and for making investment decisions in the practice of players of the Ukrainian market.

Secular trends in hip fractures worldwide: opposing trends East versus West.

Science.gov (United States)

Ballane, Ghada; Cauley, Jane A; Luckey, Marjorie M; Fuleihan, Ghada El-Hajj

2014-08-01

Despite wide variations in hip rates fractures worldwide, reasons for such differences are not clear. Furthermore, secular trends in the age-specific hip fracture rates are changing the world map of this devastating disease, with the highest rise projected to occur in developing countries. The aim of our investigation is to systematically characterize secular trends in hip fractures worldwide, examine new data for various ethnic groups in the United States, evidence for divergent temporal patterns, and investigate potential contributing factors for the observed change in their epidemiology. All studies retrieved through a complex Medline Ovid search between 1966 and 2013 were examined. For each selected study, we calculated the percent annual change in age-standardized hip fracture rates de-novo. Although occurring at different time points, trend breaks in hip fracture incidence occurred in most Western countries and Oceania. After a steep rise in age-adjusted rates in these regions, a decrease became evident sometimes between the mid-seventies and nineties, depending on the country. Conversely, the data is scarce in Asia and South America, with evidence for a continuous rise in hip fracture rates, with the exception of Hong-Kong and Taiwan that seem to follow Western trends. The etiologies of these secular patterns in both the developed and the developing countries have not been fully elucidated, but the impact of urbanization is at least one plausible explanation. Data presented here show close parallels between rising rates of urbanization and hip fractures across disparate geographic locations and cultures. Once the proportion of the urban population stabilized, hip fracture rates also stabilize or begin to decrease perhaps due to the influence of other factors such as birth cohort effects, changes in bone mineral density and BMI, osteoporosis medication use and/or lifestyle interventions such as smoking cessation, improvement in nutritional status and fall

Genetic parameters of body weight and prolificacy in pigeons

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Beaumont Catherine

2000-07-01

Full Text Available Abstract Genetic parameters of body weight at weaning and of prolificacy were estimated in three commercial lines of pigeons selected by BLUP (Best Linear Unbiased Prediction on both traits. The model of analysis took into account the direct genetic effects for both traits and the effect of parental permanent environment for body weight. Depending on the line considered, body weight varied from 556.7 g to 647.6 g and prolificacy ranged from 12.5 to 16.8 pigeons weaned per couple of parents per year. Heritability of body weight was high, varying between 0.46 and 0.60, and permanent environment was responsible for 6% to 9% of the total variability. On the contrary, prolificacy was poorly heritable (0.04 to 0.12. They were highly and negatively correlated (-0.77 to -0.82. Body weight showed significant genetic trends in lines B and C. No significant genetic difference could be observed between males and females for both traits.