WorldWideScience

Sample records for determining optimal timing

  1. Spectroscopic determination of optimal hydration time of zircon surface

    Energy Technology Data Exchange (ETDEWEB)

    Ordonez R, E. [ININ, Departamento de Quimica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Garcia R, G. [Instituto Tecnologico de Toluca, Division de Estudios del Posgrado, Av. Tecnologico s/n, Ex-Rancho La Virgen, 52140 Metepec, Estado de Mexico (Mexico); Garcia G, N., E-mail: eduardo.ordonez@inin.gob.m [Universidad Autonoma del Estado de Mexico, Facultad de Quimica, Av. Colon y Av. Tollocan, 50180 Toluca, Estado de Mexico (Mexico)

    2010-07-01

    When a mineral surface is immersed in an aqueous solution, it develops and electric charge produced by the amphoteric dissociation of hydroxyl groups created by the hydration of the solid surface. This is one influential surface property. The complete hydration process takes a time which is specific for each mineral species. The knowledge of the aqueous solution contact time for complete surface hydration is mandatory for further surface phenomena studies. This study deals with the optimal hydration time of the raw zircon (ZrSiO{sub 4}) surface comparing the classical potentiometric titrations with a fluorescence spectroscopy technique. The latter is easy and rea liable as it demands only one sample batch to determine the optimal time to ensure a total hydration of the zircon surface. The analytical results of neutron activation analysis showed the presence of trace quantities of Dy{sup 3+}, Eu{sup 3+} and Er{sup 3} in the bulk of zircon. The Dy{sup 3+} is structured in the zircon crystalline lattice and undergoes the same chemical reactions as zircon. Furthermore, the Dy{sup 3+} has a good fluorescent response whose intensity is enhanced by hydration molecules. The results show that, according to the potentiometric analysis, the hydration process for each batch (at least 8 sample batches) takes around 2 h, while the spectrometric method indicates only 5 minutes from only one batch. Both methods showed that the zircon surface have a 16 h optimal hydration time. (Author)

  2. Spectroscopic determination of optimal hydration time of zircon surface

    International Nuclear Information System (INIS)

    Ordonez R, E.; Garcia R, G.; Garcia G, N.

    2010-01-01

    When a mineral surface is immersed in an aqueous solution, it develops and electric charge produced by the amphoteric dissociation of hydroxyl groups created by the hydration of the solid surface. This is one influential surface property. The complete hydration process takes a time which is specific for each mineral species. The knowledge of the aqueous solution contact time for complete surface hydration is mandatory for further surface phenomena studies. This study deals with the optimal hydration time of the raw zircon (ZrSiO 4 ) surface comparing the classical potentiometric titrations with a fluorescence spectroscopy technique. The latter is easy and rea liable as it demands only one sample batch to determine the optimal time to ensure a total hydration of the zircon surface. The analytical results of neutron activation analysis showed the presence of trace quantities of Dy 3+ , Eu 3+ and Er 3 in the bulk of zircon. The Dy 3+ is structured in the zircon crystalline lattice and undergoes the same chemical reactions as zircon. Furthermore, the Dy 3+ has a good fluorescent response whose intensity is enhanced by hydration molecules. The results show that, according to the potentiometric analysis, the hydration process for each batch (at least 8 sample batches) takes around 2 h, while the spectrometric method indicates only 5 minutes from only one batch. Both methods showed that the zircon surface have a 16 h optimal hydration time. (Author)

  3. Optimization of experimental conditions in uranium trace determination using laser time-resolved fluorimetry

    International Nuclear Information System (INIS)

    Baly, L.; Garcia, M.A.

    1996-01-01

    At the present paper a new sample excitation geometry is presented for the uranium trace determination in aqueous solutions by the Time-Resolved Laser-Induced Fluorescence. This new design introduces the laser radiation through the top side of the cell allowing the use of cells with two quartz sides, less expensive than commonly used at this experimental set. Optimization of the excitation conditions, temporal discrimination and spectral selection are presented

  4. Simplex optimization of the variables influencing the determination of pefloxacin by time-resolved chemiluminescence

    Science.gov (United States)

    Murillo Pulgarín, José A.; Alañón Molina, Aurelia; Jiménez García, Elisa

    2018-03-01

    A new chemiluminescence (CL) detection system combined with flow injection analysis (FIA) for the determination of Pefloxacin is proposed. The determination is based on an energy transfer from Pefloxacin to terbium (III). The metal ion enhances the weak CL signal produced by the KMnO4/H2SO3/Pefloxacin system. A modified simplex method was used to optimize chemical and instrumental variables. The influence of the interaction of the permanganate, Tb (III), sodium sulphite and sulphuric acid concentrations, flow rate and injected sample volume was thoroughly investigated by using a modified simplex optimization procedure. The results revealed a strong direct relationship between flow rate and CL intensity throughout the studied range that was confirmed by a gamma test. The response factor for the CL emission intensity was used to assess performance in order to identify the optimum conditions for maximization of the response. Under such conditions, the CL response was proportional to the Pefloxacin concentration over a wide range. The detection limit as calculated according to Clayton's criterion 13.7 μg L- 1. The analyte was successfully determined in milk samples with an average recovery of 100.6 ± 9.8%.

  5. MDCT urography: retrospective determination of optimal delay time after intravenous contrast administration

    International Nuclear Information System (INIS)

    Meindl, Thomas; Coppenrath, Eva; Kahlil, Rami; Reiser, Maximilian F.; Mueller-Lisse, U.G.; Mueller-Lisse, Ulrike L.

    2006-01-01

    The optimal delay time after intravenous (i.v.) administration of contrast medium (CM) for opacifcation of the upper urinary tract (UUT) for multidetector computed tomography urography (MDCTU) was investigated. UUT opacification was retrospectively evaluated in 36 four-row MDCTU examinations. Single- (n=10) or dual-phase (n=26) MDCTU was performed with at least 5-min delay after i.v. CM. UUT was divided into four sections: intrarenal collecting system (IRCS), proximal, middle and distal ureter. Two independent readers rated UUT opacification: 1, none; 2, partial; 3, complete. Numbers and percentages of scores, and the 5%, 25%, 50%, 75% and 95% percentiles of delay time were calculated for each UUT section. After removing diseased segments, 344 segments were analysed. IRCS, proximal and middle ureter were completely opacified in 94% (81/86), 93% (80/86) and 77% (66/86) of cases, respectively. Median delay time was 15 min for complete opacification. The distal ureter was completely opacified in 37% (32/86) of cases and not opacified in 26% (22/86). Median delay time for complete opacification was 11 min with 25% and 75% percentiles of 10 and 16 min, respectively. At MDCTU, opacification of the IRCS, proximal and middle ureter was hardly sensitive to delay time. Delay times between 10 and 16 min were favourable in the distal ureter. (orig.)

  6. Modeling and analysis for determining optimal suppliers under stochastic lead times

    DEFF Research Database (Denmark)

    Abginehchi, Soheil; Farahani, Reza Zanjirani

    2010-01-01

    systems. The item acquisition lead times of suppliers are random variables. Backorder is allowed and shortage cost is charged based on not only per unit in shortage but also per time unit. Continuous review (s,Q) policy has been assumed. When the inventory level depletes to a reorder level, the total...... order is split among n suppliers. Since the suppliers have different characteristics, the quantity ordered to different suppliers may be different. The problem is to determine the reorder level and quantity ordered to each supplier so that the expected total cost per time unit, including ordering cost...

  7. Determining Optimal Decision Version

    Directory of Open Access Journals (Sweden)

    Olga Ioana Amariei

    2014-06-01

    Full Text Available In this paper we start from the calculation of the product cost, applying the method of calculating the cost of hour- machine (THM, on each of the three cutting machines, namely: the cutting machine with plasma, the combined cutting machine (plasma and water jet and the cutting machine with a water jet. Following the calculation of cost and taking into account the precision of manufacturing of each machine, as well as the quality of the processed surface, the optimal decisional version needs to be determined regarding the product manufacturing. To determine the optimal decisional version, we resort firstly to calculating the optimal version on each criterion, and then overall using multiattribute decision methods.

  8. Real time production optimization

    Energy Technology Data Exchange (ETDEWEB)

    Saputelli, Luigi; Otavio, Joao; Araujo, Turiassu; Escorcia, Alvaro [Halliburton, Houston, TX (United States). Landmark Division

    2004-07-01

    Production optimization encompasses various activities of measuring, analyzing, modeling, prioritizing and implementing actions to enhance productivity of a field. We present a state-of-the-art framework for optimizing production on a continuous basis as new sensor data is acquired in real time. Permanently acquired data is modeled and analyzed in order to create predictive models. A model based control strategy is used to regulate well and field instrumentation. The optimum field operating point, which changes with time, satisfies the maximum economic return. This work is a starting point for further development in automatic, intelligent reservoir technologies which get the most out of the abilities of permanent, instrumented wells and remotely activated downhole completions. The strategy, tested with history-matched data from a compartmentalised giant field, proved to reduce operating costs while increasing oil recovery by 27% in this field. (author)

  9. Time-Space Topology Optimization

    DEFF Research Database (Denmark)

    Jensen, Jakob Søndergaard

    2008-01-01

    A method for space-time topology optimization is outlined. The space-time optimization strategy produces structures with optimized material distributions that vary in space and in time. The method is demonstrated for one-dimensional wave propagation in an elastic bar that has a time-dependent Young......’s modulus and is subjected to a transient load. In the example an optimized dynamic structure is demonstrated that compresses a propagating Gauss pulse....

  10. Time optimal paths for high speed maneuvering

    Energy Technology Data Exchange (ETDEWEB)

    Reister, D.B.; Lenhart, S.M.

    1993-01-01

    Recent theoretical results have completely solved the problem of determining the minimum length path for a vehicle with a minimum turning radius moving from an initial configuration to a final configuration. Time optimal paths for a constant speed vehicle are a subset of the minimum length paths. This paper uses the Pontryagin maximum principle to find time optimal paths for a constant speed vehicle. The time optimal paths consist of sequences of axes of circles and straight lines. The maximum principle introduces concepts (dual variables, bang-bang solutions, singular solutions, and transversality conditions) that provide important insight into the nature of the time optimal paths. We explore the properties of the optimal paths and present some experimental results for a mobile robot following an optimal path.

  11. The Optimal Time of Renovating a Mall

    OpenAIRE

    K.C. Wong; George Norman

    1994-01-01

    This paper presents a maximization model determining the optimal time at which a mall should be renovated. The analysis is constructed on the assumption of a decreasing rental income over time as a mall ages. It is then shown that the optimal renovation period achieves a balance between the marginal cost and benefits of delaying renovation. We show how this balance is affected by changes in the discount rate, net rental incomes, and renovation costs. Numerical simulations are used to demonstr...

  12. Multidisciplinary Approach to Determine the Optimal Time and Period for Extracting the Essential Oil from Mentha suaveolens Ehrh

    Directory of Open Access Journals (Sweden)

    Stefania Garzoli

    2015-05-01

    Full Text Available A comprehensive study on essential oils (EOs extracted from some Mentha suaveolens L. samples, collected in the countryside of Tarquinia, is reported. In this study, the procedure for essential oil preparation, in terms of harvesting and extraction time, was analyzed in detail for the first time. The GC/MS analysis, carried out on 18 samples, revealed that piperitenone oxide (PO, the main essential oils’ chemical constituent, is primarily responsible for the related antifungal activity. Nevertheless, EOs with lower PO content indicate that other chemicals, such as para-cymenene, may participate in exerting the EOs’ antifungal effect. Furthermore, the bacterial reverse mutation assay highlighted lack of mutagenic effect in all tested samples. Analysis of the results indicated that for higher activity, the essential oils should be produced with 3 h maximum hydrodistillation, regardless of the harvesting time. Differently, the maximum essential oil yield can be obtained in August and the highest piperitenone oxide percentage is obtainable in July.

  13. Influence of the weighing bar size to determine optimal time of biodiesel-glycerol separation by using the buoyancy weighing-bar method

    Science.gov (United States)

    Tambun, R.; Sibagariang, Y.; Manurung, J.

    2018-02-01

    The buoyancy weighing-bar method is a novel method in the particle size distribution measurement. This method can measure particle size distributions of the settling particles and floating particles. In this study, the buoyancy weighing-bar method is applied to determine optimal time of biodiesel-glycerol separation. The buoyancy weighing-bar method can be applied to determine the separation time because biodiesel and glycerol have the different densities. The influences of diameter of weighing-bar by using the buoyancy weighing-bar method would be experimentally investigated. The diameters of weighing-bar in this experiment are 8 mm, 10 mm, 15 mm and 20 mm, while the graduated cylinder (diameter : 65 mm) is used as vessel. The samples used in this experiment are the mixture of 95 % of biodiesel and 5 % of glycerol. The data obtained by the buoyancy weighing-bar method are analized by using the gas chromatography to determine the purity of biodiesel. Based on the data obtained, the buoyancy weighing-bar method can be used to detect the separation time of biodiesel-glycerol by using the weighing-bar diameter of 8 mm, 10 mm, 15 mm and 20 mm, but the most accuracy in determination the biodiesel-glycerol separation time is obtained by using the weighing-bar diameter of 20 mm. The biodiesel purity of 97.97 % could be detected at 64 minutes by using the buoyancy weighing-bar method when the weighing-bar diameter of 20 mm is used.

  14. Optimization of time characteristics in activation analysis

    International Nuclear Information System (INIS)

    Gurvich, L.G.; Umaraliev, A.T.

    2006-01-01

    Full text: The activation analysis temporal characteristics optimization methods developed at present are aimed at determination of optimal values of the three important parameters - irradiation time, cooling time and measurement time. In the performed works, especially in [1-5] the activation analysis processes are described, the optimal values of optimization parameters are obtained from equations solved, and the computational results are given for these parameters for a number of elements. However, the equations presented in [2] were inaccurate, did not allow one to have optimization parameters results for one element content calculations, and it did not take into account background dependence of time. Therefore, we proposed modified equations to determine the optimal temporal parameters and iteration processes for the solution of these equations. It is well-known that the activity of studied sample during measurements does not change significantly, i.e. measurement time is much shorter than the half-life, thus the processes taking place can be described by the Poisson probability distribution, and in general case one can apply binomial distribution. The equation and iteration processes use in this research describe both probability distributions. Expectedly, the cooling time iteration expressions obtained for one element analysis case are similar for the both distribution types, as the optimised time values occurred to be of the same order as half-life values, whereas the cooling time, as we observed, depends on the ratio of the studied sample's peak value to the background peak, and can be significantly larger than the half-life value. This pattern is general, and can be derived from the optimized time expressions, which is supported by the experimental data on short-living isotopes [3,4]. For the isotopes with large half-lives, up to years, like cobalt-60, the cooling time values given in the above mentioned works are equal to months which, apparently

  15. Time Optimal Control Laws for Bilinear Systems

    Directory of Open Access Journals (Sweden)

    Salim Bichiou

    2018-01-01

    Full Text Available The aim of this paper is to determine the feedforward and state feedback suboptimal time control for a subset of bilinear systems, namely, the control sequence and reaching time. This paper proposes a method that uses Block pulse functions as an orthogonal base. The bilinear system is projected along that base. The mathematical integration is transformed into a product of matrices. An algebraic system of equations is obtained. This system together with specified constraints is treated as an optimization problem. The parameters to determine are the final time, the control sequence, and the states trajectories. The obtained results via the newly proposed method are compared to known analytical solutions.

  16. Determination of absorption changes from moments of distributions of times of flight of photons: optimization of measurement conditions for a two-layered tissue model.

    Science.gov (United States)

    Liebert, Adam; Wabnitz, Heidrun; Elster, Clemens

    2012-05-01

    Time-resolved near-infrared spectroscopy allows for depth-selective determination of absorption changes in the adult human head that facilitates separation between cerebral and extra-cerebral responses to brain activation. The aim of the present work is to analyze which combinations of moments of measured distributions of times of flight (DTOF) of photons and source-detector separations are optimal for the reconstruction of absorption changes in a two-layered tissue model corresponding to extra- and intra-cerebral compartments. To this end we calculated the standard deviations of the derived absorption changes in both layers by considering photon noise and a linear relation between the absorption changes and the DTOF moments. The results show that the standard deviation of the absorption change in the deeper (superficial) layer increases (decreases) with the thickness of the superficial layer. It is confirmed that for the deeper layer the use of higher moments, in particular the variance of the DTOF, leads to an improvement. For example, when measurements at four different source-detector separations between 8 and 35 mm are available and a realistic thickness of the upper layer of 12 mm is assumed, the inclusion of the change in mean time of flight, in addition to the change in attenuation, leads to a reduction of the standard deviation of the absorption change in the deeper tissue layer by a factor of 2.5. A reduction by another 4% can be achieved by additionally including the change in variance.

  17. Sex reversal of brook trout (Salvelinus fontinalis) by 17α-methyltestosterone exposure: A serial experimental approach to determine optimal timing and delivery regimes.

    Science.gov (United States)

    Fatima, Shafaq; Adams, Mark; Wilkinson, Ryan

    2016-12-01

    Commercial culture of Brook trout (Salvelinus fontinalis) in Tasmania was partly abandoned due to sexual maturation of male fish early on during the estuarine rearing phase. Maturation adversely affects body mass, flesh quality and immunocompetency effectively. Sex reversal techniques such as the in-feed addition of a synthetic androgen have proven difficult to adapt in brook trout. An appropriate timing, duration and delivery vehicle for administration of 17α-methyltestosterone (MT) to produce phenotypic males (neomales) from genotypically female brook trout required further investigation. In this study, groups of brook trout eggs (n=1000) maintained at 9.5±0.15-10±0.14°C, were immersed in MT (400μgL -1 ) for four hours on two alternate days (two immersions/group) staggered over a two week period surrounding the hatch of embryos (control groups excluded). The groups were then split and half received MT-supplemented feed for 60days and the other a standard diet. Following an 11 month on-growing period sex phenotypes were determined by gross & histological gonad morphology. The highest proportion of male phenotypes (75%) was found in fish immersed six and four days pre-hatch and subsequently fed a normal diet. Fish fed a MT supplemented diet and immersed in MT showed significantly higher proportions of sterile fish. These data indicate that a pre-hatch immersion-only regime (4-6days pre-hatch at 9.5°C) should be pursued as a target for optimization studies to further refine the effective concentration and duration of exposure to MT for the successful production of neo-male brook trout. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Determination of optimal acquisition time of [18F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

    International Nuclear Information System (INIS)

    Yong Choi, Jae; Lee, Minkyung; Jeon, Tae Joo; Choi, Soo-Hee; Choi, Ye Ji; Lee, Yu Kyung; Kim, Jae-Jin; Ryu, Young Hoon

    2014-01-01

    The purpose of this research is to find optimal acquisition time point of [ 18 F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT 1A ) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT 1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90 min after injection and remained stable at 120 min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90 min p.i. is a better single time point for the analysis rather than previous time points for assessing [ 18 F]FCWAY binding to 5-HT 1A receptors. - Highlights: • For routine clinical study, PET protocol should be conducted on a single time point with short imaging acquisition. • The specific-to-nonspecific ratios in the various brain regions were calculated. • Optimal [ 18 F]FCWAY PET acquisition time point was proposed

  19. Time series livestock diet optimization

    NARCIS (Netherlands)

    Alqaisi, Othman; Ndambi, Oghaiki Asaah; Williams, Ryan Blake

    2017-01-01

    Sustainable feed formulation (defined here as nutritional and economic feed optimization) is substantial in feed chain production from crop farmers to livestock producers. Diet formulation employing a static linear programming (LP) approach, which is widely used in trading firms and feed production

  20. PROCESS TIME OPTIMIZATION IN DEPOSITOR AND FILLER

    Directory of Open Access Journals (Sweden)

    Jesús Iván Ruíz-Ibarra

    2017-07-01

    Full Text Available As in any industry, in soft drink manufacturing demand, customer service and production is of great importance that forces this production to have their equipment and production machines in optimal conditions for the product to be in the hands of the consumer without delays, therefore it is important to have the established times of each process, since the syrup is elaborated, packaged, distributed, until it is purchased by the consumer. After a chronometer analysis, the most common faults were detected in each analyzed process. In the filler machine the most frequent faults are: accumulation of bottles in the subsequent and previous processes to filling process, which in general the cause of the collection of bottles is due to failures in the other equipment of the production line. In the process of unloading the most common faults are: boxes jammed in bump and pusher (pushing boxes; boxes fallen in rollers and platforms transporter. According to observations in each machine, the actions to be followed are presented to solve the problems that arise. Also described the methodology to obtain results, to data analyze and decisions. Firstly an analysis of operations is done to know each machine, supported by the manuals of the machines and the operators themselves a study of times is done by chronometer to determine the standard time of the process where also they present the most common faults, then observations are made on the machines according to the determined sample size, thus obtaining the information necessary to take measurements and to make the study of optimization of the production processes. An analysis of the predetermined process times is also performed by the MTM methods and the MOST time analysis. The results of operators with MTM: Fault Filler = 0.846 minutes, Faultless Filler = 0.61 minutes, Fault Breaker = 0.74 minutes and Fault Flasher = 0.45 minutes. The results of MOST operators are: Fault Filler = 2.58 minutes, Filler Fails

  1. Distributed Algorithms for Time Optimal Reachability Analysis

    DEFF Research Database (Denmark)

    Zhang, Zhengkui; Nielsen, Brian; Larsen, Kim Guldstrand

    2016-01-01

    . We propose distributed computing to accelerate time optimal reachability analysis. We develop five distributed state exploration algorithms, implement them in \\uppaal enabling it to exploit the compute resources of a dedicated model-checking cluster. We experimentally evaluate the implemented...... algorithms with four models in terms of their ability to compute near- or proven-optimal solutions, their scalability, time and memory consumption and communication overhead. Our results show that distributed algorithms work much faster than sequential algorithms and have good speedup in general.......Time optimal reachability analysis is a novel model based technique for solving scheduling and planning problems. After modeling them as reachability problems using timed automata, a real-time model checker can compute the fastest trace to the goal states which constitutes a time optimal schedule...

  2. Determining an optimal supply chain strategy

    Directory of Open Access Journals (Sweden)

    Intaher M. Ambe

    2012-11-01

    Full Text Available In today’s business environment, many companies want to become efficient and flexible, but have struggled, in part, because they have not been able to formulate optimal supply chain strategies. Often this is as a result of insufficient knowledge about the costs involved in maintaining supply chains and the impact of the supply chain on their operations. Hence, these companies find it difficult to manufacture at a competitive cost and respond quickly and reliably to market demand. Mismatched strategies are the root cause of the problems that plague supply chains, and supply-chain strategies based on a one-size-fits-all strategy often fail. The purpose of this article is to suggest instruments to determine an optimal supply chain strategy. This article, which is conceptual in nature, provides a review of current supply chain strategies and suggests a framework for determining an optimal strategy.

  3. Time-optimal control with finite bandwidth

    Science.gov (United States)

    Hirose, M.; Cappellaro, P.

    2018-04-01

    Time-optimal control theory provides recipes to achieve quantum operations with high fidelity and speed, as required in quantum technologies such as quantum sensing and computation. While technical advances have achieved the ultrastrong driving regime in many physical systems, these capabilities have yet to be fully exploited for the precise control of quantum systems, as other limitations, such as the generation of higher harmonics or the finite response time of the control apparatus, prevent the implementation of theoretical time-optimal control. Here we present a method to achieve time-optimal control of qubit systems that can take advantage of fast driving beyond the rotating wave approximation. We exploit results from time-optimal control theory to design driving protocols that can be implemented with realistic, finite-bandwidth control fields, and we find a relationship between bandwidth limitations and achievable control fidelity.

  4. Optimal transformations for categorical autoregressive time series

    NARCIS (Netherlands)

    Buuren, S. van

    1996-01-01

    This paper describes a method for finding optimal transformations for analyzing time series by autoregressive models. 'Optimal' implies that the agreement between the autoregressive model and the transformed data is maximal. Such transformations help 1) to increase the model fit, and 2) to analyze

  5. Optimal Guaranteed Service Time and Service Level Decision with Time and Service Level Sensitive Demand

    Directory of Open Access Journals (Sweden)

    Sangjun Park

    2014-01-01

    Full Text Available We consider a two-stage supply chain with one supplier and one retailer. The retailer sells a product to customer and the supplier provides a product in a make-to-order mode. In this case, the supplier’s decisions on service time and service level and the retailer’s decision on retail price have effects on customer demand. We develop optimization models to determine the optimal retail price, the optimal guaranteed service time, the optimal service level, and the optimal capacity to maximize the expected profit of the whole supply chain. The results of numerical experiments show that it is more profitable to determine the optimal price, the optimal guaranteed service time, and the optimal service level simultaneously and the proposed model is more profitable in service level sensitive market.

  6. Optimal Time to Enter a Retirement Village

    Directory of Open Access Journals (Sweden)

    Jinhui Zhang

    2017-03-01

    Full Text Available We consider the financial planning problem of a retiree wishing to enter a retirement village at a future uncertain date. The date of entry is determined by the retiree’s utility and bequest maximisation problem within the context of uncertain future health states. In addition, the retiree must choose optimal consumption, investment, bequest and purchase of insurance products prior to their full annuitisation on entry to the retirement village. A hyperbolic absolute risk-aversion (HARA utility function is used to allow necessary consumption for basic living and medical costs. The retirement village will typically require an initial deposit upon entry. This threshold wealth requirement leads to exercising the replication of an American put option at the uncertain stopping time. From our numerical results, active insurance and annuity markets are shown to be a critical aspect in retirement planning.

  7. Determination of Optimal Harvest Time of Chuchung Variety Green Rice(®) (Oryza sativa L.) with High Contents of GABA, γ-Oryzanol, and α-Tocopherol.

    Science.gov (United States)

    Kim, Hoon; Kim, Oui-Woung; Ha, Ae Wha; Park, Soojin

    2016-06-01

    In our previous study, an early-maturing variety of rice (Oryza sativa L.), Jinbu can have feature with unique green color, various phytochemicals as well as nutritive components by the optimal early harvesting, called Green Rice(®) (GR). The aims of the present field experiments were to evaluate the changes in the weight of 1,000 kernels, yield, and contents of proximate and bioactive compounds in Chuchung, a mid-late maturing variety, during the pre-harvest maturation of rough rice and to research the appropriate harvest time and potent bioactivity of Chuchung GR. The weights of 1,000 kernels of Chuchung GR dramatically increased until 27 days after heading (DAH). The yields of Chuchung GR declined after 27 DAH and significantly declined to 0.0% after 45 DAH. The caloric value and total mineral contents were higher in the GR than in the full ripe stage, the brown rice (BR). In the GR, the contents of bioactive compounds, such as γ-aminobutyric acid, γ-oryzanol, and α-tocopherol, were much higher (P<0.05) than those in the BR, specifically during 24~27 DAH. Therefore, bioactive Chuchung GR can be produced with a reasonable yield at 24~27 DAH and it could be useful for applications in various nutritive and functional food products.

  8. Determination of Optimal Harvest Time of Chuchung Variety Green Rice® (Oryza sativa L.) with High Contents of GABA, γ-Oryzanol, and α-Tocopherol

    Science.gov (United States)

    Kim, Hoon; Kim, Oui-Woung; Ha, Ae Wha; Park, Soojin

    2016-01-01

    In our previous study, an early-maturing variety of rice (Oryza sativa L.), Jinbu can have feature with unique green color, various phytochemicals as well as nutritive components by the optimal early harvesting, called Green Rice® (GR). The aims of the present field experiments were to evaluate the changes in the weight of 1,000 kernels, yield, and contents of proximate and bioactive compounds in Chuchung, a mid-late maturing variety, during the pre-harvest maturation of rough rice and to research the appropriate harvest time and potent bioactivity of Chuchung GR. The weights of 1,000 kernels of Chuchung GR dramatically increased until 27 days after heading (DAH). The yields of Chuchung GR declined after 27 DAH and significantly declined to 0.0% after 45 DAH. The caloric value and total mineral contents were higher in the GR than in the full ripe stage, the brown rice (BR). In the GR, the contents of bioactive compounds, such as γ-aminobutyric acid, γ-oryzanol, and α-tocopherol, were much higher (P<0.05) than those in the BR, specifically during 24~27 DAH. Therefore, bioactive Chuchung GR can be produced with a reasonable yield at 24~27 DAH and it could be useful for applications in various nutritive and functional food products. PMID:27390725

  9. Optimizing departure times in vehicle routes

    NARCIS (Netherlands)

    Kok, A.L.; Hans, Elias W.; Schutten, Johannes M.J.

    2008-01-01

    Most solution methods for the vehicle routing problem with time windows (VRPTW) develop routes from the earliest feasible departure time. However, in practice, temporal traffic congestions make that such solutions are not optimal with respect to minimizing the total duty time. Furthermore, VRPTW

  10. Optimizing Departure Times in Vehicle Routes

    NARCIS (Netherlands)

    Kok, A.L.; Hans, Elias W.; Schutten, Johannes M.J.

    2011-01-01

    Most solution methods for the vehicle routing problem with time windows (VRPTW) develop routes from the earliest feasible departure time. In practice, however, temporary traffic congestion make such solutions non-optimal with respect to minimizing the total duty time. Furthermore, the VRPTW does not

  11. Time Optimal Reachability Analysis Using Swarm Verification

    DEFF Research Database (Denmark)

    Zhang, Zhengkui; Nielsen, Brian; Larsen, Kim Guldstrand

    2016-01-01

    Time optimal reachability analysis employs model-checking to compute goal states that can be reached from an initial state with a minimal accumulated time duration. The model-checker may produce a corresponding diagnostic trace which can be interpreted as a feasible schedule for many scheduling...... and planning problems, response time optimization etc. We propose swarm verification to accelerate time optimal reachability using the real-time model-checker Uppaal. In swarm verification, a large number of model checker instances execute in parallel on a computer cluster using different, typically randomized...... search strategies. We develop four swarm algorithms and evaluate them with four models in terms scalability, and time- and memory consumption. Three of these cooperate by exchanging costs of intermediate solutions to prune the search using a branch-and-bound approach. Our results show that swarm...

  12. Optimal scheduling using priced timed automata

    DEFF Research Database (Denmark)

    Behrmann, Gerd; Larsen, Kim Guldstrand; Rasmussen, Jacob Illum

    2005-01-01

    This contribution reports on the considerable effort made recently towards extending and applying well-established timed automata technology to optimal scheduling and planning problems. The effort of the authors in this direction has to a large extent been carried out as part of the European...... projects VHS [20] and AMETIST [16] and are available in the recently released UPPAAL CORA [12], a variant of the real-time verification tool UPPAAL [18, 5] specialized for cost-optimal reachability for the extended model of so-called priced timed automata....

  13. Optimal time points sampling in pathway modelling.

    Science.gov (United States)

    Hu, Shiyan

    2004-01-01

    Modelling cellular dynamics based on experimental data is at the heart of system biology. Considerable progress has been made to dynamic pathway modelling as well as the related parameter estimation. However, few of them gives consideration for the issue of optimal sampling time selection for parameter estimation. Time course experiments in molecular biology rarely produce large and accurate data sets and the experiments involved are usually time consuming and expensive. Therefore, to approximate parameters for models with only few available sampling data is of significant practical value. For signal transduction, the sampling intervals are usually not evenly distributed and are based on heuristics. In the paper, we investigate an approach to guide the process of selecting time points in an optimal way to minimize the variance of parameter estimates. In the method, we first formulate the problem to a nonlinear constrained optimization problem by maximum likelihood estimation. We then modify and apply a quantum-inspired evolutionary algorithm, which combines the advantages of both quantum computing and evolutionary computing, to solve the optimization problem. The new algorithm does not suffer from the morass of selecting good initial values and being stuck into local optimum as usually accompanied with the conventional numerical optimization techniques. The simulation results indicate the soundness of the new method.

  14. Time-optimal control of reactor power

    International Nuclear Information System (INIS)

    Bernard, J.A.

    1987-01-01

    Control laws that permit adjustments in reactor power to be made in minimum time and without overshoot have been formulated and demonstrated. These control laws which are derived from the standard and alternate dynamic period equations, are closed-form expressions of general applicability. These laws were deduced by noting that if a system is subject to one or more operating constraints, then the time-optimal response is to move the system along these constraints. Given that nuclear reactors are subject to limitations on the allowed reactor period, a time-optimal control law would step the period from infinity to the minimum allowed value, hold the period at that value for the duration of the transient, and then step the period back to infinity. The change in reactor would therefore be accomplished in minimum time. The resulting control laws are superior to other forms of time-optimal control because they are general-purpose, closed-form expressions that are both mathematically tractable and readily implanted. Moreover, these laws include provisions for the use of feedback. The results of simulation studies and actual experiments on the 5 MWt MIT Research Reactor in which these time-optimal control laws were used successfully to adjust the reactor power are presented

  15. Optimal Conditional Reachability for Multi-Priced Timed Automata

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Rasmussen, Jacob Illum

    2005-01-01

    In this paper, we prove decidability of the optimal conditional reachability problem for multi-priced timed automata, an extension of timed automata with multiple cost variables evolving according to given rates for each location. More precisely, we consider the problem of determining the minimal...

  16. The determination of optimal climate policy

    International Nuclear Information System (INIS)

    Aaheim, Asbjoern

    2010-01-01

    Analyses of the costs and benefits of climate policy, such as the Stern Review, evaluate alternative strategies to reduce greenhouse gas emissions by requiring that the cost of emission cuts in each and every year has to be covered by the associated value of avoided damage, discounted by a an exogenously chosen rate. An alternative is to optimize abatement programmes towards a stationary state, where the concentrations of greenhouse gases are stabilized and shadow prices, including the rate of discount, are determined endogenously. This paper examines the properties of optimized stabilization. It turns out that the implications for the evaluation of climate policy are substantial if compared with evaluations of the present value of costs and benefits based on exogenously chosen shadow prices. Comparisons of discounted costs and benefits tend to exaggerate the importance of the choice of discount rate, while ignoring the importance of future abatement costs, which turns out to be essential for the optimal abatement path. Numerical examples suggest that early action may be more beneficial than indicated by comparisons of costs and benefits discounted by a rate chosen on the basis of current observations. (author)

  17. Investment under uncertainty : Timing and capacity optimization

    NARCIS (Netherlands)

    Wen, Xingang

    2017-01-01

    This thesis consists of three chapters on analyzing the optimal investment timing and investment capacity for the firm(s) undertaking irreversible investment in an uncertain environment. Chapter 2 studies the investment decision of a monopoly firm when it can adjust output quantity in a market with

  18. Split-time artificial insemination in beef cattle: I-Using estrous response to determine the optimal time(s) at which to administer GnRH in beef heifers and postpartum cows.

    Science.gov (United States)

    Bishop, B E; Thomas, J M; Abel, J M; Poock, S E; Ellersieck, M R; Smith, M F; Patterson, D J

    2016-09-01

    Two experiments evaluated timing of GnRH administration in beef heifers and cows on the basis of estrous status during split-time artificial insemination (AI) after controlled internal drug release (CIDR) based protocols. In experiment 1, estrus was synchronized for 816 pubertal and prepubertal or peripubertal heifers using the 14-day CIDR-PGF2α (PG) protocol, and in experiment 2, estrus was synchronized for 622 lactating cows using the 7-day CO-Synch + CIDR protocol. For both experiments, estrus detection aids (Estrotect) were applied at PG, with estrus recorded at 66 and 90 hours after PG. Treatments were balanced across locations for heifers using reproductive tract score and weight; whereas for cows, treatments were assigned and balanced to treatment according to age, body condition score, and days postpartum. Timing of AI for heifers and cows was on the basis of estrus expression 66 hours after PG. Females in each treatment that exhibited estrus before 66 hours were inseminated at 66 hours, whereas AI was delayed 24 hours until 90 hours after PG for females failing to exhibit estrus before 66 hours. Females in treatment one received GnRH 66 hours after PG irrespective of estrus expression; however, in treatment 2, GnRH was administered coincident with delayed AI only to females not detected in estrus at 66 hours after PG. Among heifers, there was no effect of treatment on overall estrous response (P = 0.49) or AI pregnancy rate (P = 0.54). Pregnancy rate for heifers inseminated at 66 hours was not influenced by GnRH (P = 0.65), and there were no differences between treatments in estrous response during the 24 hours delay period (P = 0.22). Cows in treatment 2 had a greater (P = 0.04) estrous response during the 24-hour delay period resulting in a greater overall estrous response (P = 0.04), but this did not affect AI pregnancy rate at 90 hours (P = 0.51) or total AI pregnancy rate (P = 0.89). Pregnancy rate resulting from AI for

  19. Optimal, real-time control--colliders

    International Nuclear Information System (INIS)

    Spencer, J.E.

    1991-05-01

    With reasonable definitions, optimal control is possible for both classical and quantal systems with new approaches called PISC(Parallel) and NISC(Neural) from analogy with RISC (Reduced Instruction Set Computing). If control equals interaction, observation and comparison to some figure of merit with interaction via external fields, then optimization comes from varying these fields to give design or operating goals. Structural stability can then give us tolerance and design constraints. But simulations use simplified models, are not in real-time and assume fixed or stationary conditions, so optimal control goes far beyond convergence rates of algorithms. It is inseparable from design and this has many implications for colliders. 12 refs., 3 figs

  20. A Feedback Optimal Control Algorithm with Optimal Measurement Time Points

    Directory of Open Access Journals (Sweden)

    Felix Jost

    2017-02-01

    Full Text Available Nonlinear model predictive control has been established as a powerful methodology to provide feedback for dynamic processes over the last decades. In practice it is usually combined with parameter and state estimation techniques, which allows to cope with uncertainty on many levels. To reduce the uncertainty it has also been suggested to include optimal experimental design into the sequential process of estimation and control calculation. Most of the focus so far was on dual control approaches, i.e., on using the controls to simultaneously excite the system dynamics (learning as well as minimizing a given objective (performing. We propose a new algorithm, which sequentially solves robust optimal control, optimal experimental design, state and parameter estimation problems. Thus, we decouple the control and the experimental design problems. This has the advantages that we can analyze the impact of measurement timing (sampling independently, and is practically relevant for applications with either an ethical limitation on system excitation (e.g., chemotherapy treatment or the need for fast feedback. The algorithm shows promising results with a 36% reduction of parameter uncertainties for the Lotka-Volterra fishing benchmark example.

  1. Optimization and analysis of a quantitative real-time PCR-based technique to determine microRNA expression in formalin-fixed paraffin-embedded samples

    Directory of Open Access Journals (Sweden)

    Reis Patricia P

    2010-06-01

    Full Text Available Abstract Background MicroRNAs (miRs are non-coding RNA molecules involved in post-transcriptional regulation, with diverse functions in tissue development, differentiation, cell proliferation and apoptosis. miRs may be less prone to degradation during formalin fixation, facilitating miR expression studies in formalin-fixed paraffin-embedded (FFPE tissue. Results Our study demonstrates that the TaqMan Human MicroRNA Array v1.0 (Early Access platform is suitable for miR expression analysis in FFPE tissue with a high reproducibility (correlation coefficients of 0.95 between duplicates, p 35, we show that reproducibility between technical replicates, equivalent dilutions, and FFPE vs. frozen samples is best in the high abundance stratum. We also demonstrate that the miR expression profiles of FFPE samples are comparable to those of fresh-frozen samples, with a correlation of up to 0.87 (p Conclusion Our study thus demonstrates the utility, reproducibility, and optimization steps needed in miR expression studies using FFPE samples on a high-throughput quantitative PCR-based miR platform, opening up a realm of research possibilities for retrospective studies.

  2. Determination of the Prosumer's Optimal Bids

    Science.gov (United States)

    Ferruzzi, Gabriella; Rossi, Federico; Russo, Angela

    2015-12-01

    This paper considers a microgrid connected with a medium-voltage (MV) distribution network. It is assumed that the microgrid, which is managed by a prosumer, operates in a competitive environment and participates in the day-ahead market. Then, as the first step of the short-term management problem, the prosumer must determine the bids to be submitted to the market. The offer strategy is based on the application of an optimization model, which is solved for different hourly price profiles of energy exchanged with the main grid. The proposed procedure is applied to a microgrid and four different its configurations were analyzed. The configurations consider the presence of thermoelectric units that only produce electricity, a boiler or/and cogeneration power plants for the thermal loads, and an electric storage system. The numerical results confirmed the numerous theoretical considerations that have been made.

  3. A framework for determining optimal petroleum leasing

    International Nuclear Information System (INIS)

    Robinson, D.R.

    1991-01-01

    The techniques of auction theory and option theory are combined to allow valuation under both geologic and oil price uncertainty. The primary motivation for developing this framework is to understand the prevalence of leasing in transferring ownership of oil properties. Under a standard oil lease, the landowner sells an oil company the right to explore and develop a tract of land for a fixed period of time. If oil is found, a fraction of the revenues is reserved for the landowner. Compared to the outright sale of the minerals, leasing has the disadvantages of: (1) lowering total oil field value through alteration of investment incentives; (2) providing the seller with a more risk cash flow; and (3) increasing legal and administrative costs. It is demonstrated here that in lease sales as compared to full mineral interest sales, the relative disadvantages are offset by more effective value transfer to the seller. For the base-case parameters, the optimal lease in a bonus auction gives the seller 28% more value than the sale of the full mineral interest. There is a loss in the leasing process from distortion of development timing incentives

  4. Optimal Frequency Ranges for Sub-Microsecond Precision Pulsar Timing

    Science.gov (United States)

    Lam, Michael Timothy; McLaughlin, Maura; Cordes, James; Chatterjee, Shami; Lazio, Joseph

    2018-01-01

    Precision pulsar timing requires optimization against measurement errors and astrophysical variance from the neutron stars themselves and the interstellar medium. We investigate optimization of arrival time precision as a function of radio frequency and bandwidth. We find that increases in bandwidth that reduce the contribution from receiver noise are countered by the strong chromatic dependence of interstellar effects and intrinsic pulse-profile evolution. The resulting optimal frequency range is therefore telescope and pulsar dependent. We demonstrate the results for five pulsars included in current pulsar timing arrays and determine that they are not optimally observed at current center frequencies. We also find that arrival-time precision can be improved by increases in total bandwidth. Wideband receivers centered at high frequencies can reduce required overall integration times and provide significant improvements in arrival time uncertainty by a factor of $\\sim$$\\sqrt{2}$ in most cases, assuming a fixed integration time. We also discuss how timing programs can be extended to pulsars with larger dispersion measures through the use of higher-frequency observations.

  5. Optimization of automation: III. Development of optimization method for determining automation rate in nuclear power plants

    International Nuclear Information System (INIS)

    Lee, Seung Min; Kim, Jong Hyun; Kim, Man Cheol; Seong, Poong Hyun

    2016-01-01

    Highlights: • We propose an appropriate automation rate that enables the best human performance. • We analyze the shortest working time considering Situation Awareness Recovery (SAR). • The optimized automation rate is estimated by integrating the automation and ostracism rate estimation methods. • The process to derive the optimized automation rate is demonstrated through case studies. - Abstract: Automation has been introduced in various industries, including the nuclear field, because it is commonly believed that automation promises greater efficiency, lower workloads, and fewer operator errors through reducing operator errors and enhancing operator and system performance. However, the excessive introduction of automation has deteriorated operator performance due to the side effects of automation, which are referred to as Out-of-the-Loop (OOTL), and this is critical issue that must be resolved. Thus, in order to determine the optimal level of automation introduction that assures the best human operator performance, a quantitative method of optimizing the automation is proposed in this paper. In order to propose the optimization method for determining appropriate automation levels that enable the best human performance, the automation rate and ostracism rate, which are estimation methods that quantitatively analyze the positive and negative effects of automation, respectively, are integrated. The integration was conducted in order to derive the shortest working time through considering the concept of situation awareness recovery (SAR), which states that the automation rate with the shortest working time assures the best human performance. The process to derive the optimized automation rate is demonstrated through an emergency operation scenario-based case study. In this case study, four types of procedures are assumed through redesigning the original emergency operating procedure according to the introduced automation and ostracism levels. Using the

  6. Optimal time for initiating extracorporeal membrane oxygenation.

    Science.gov (United States)

    Haile, Dawit T; Schears, Gregory J

    2009-09-01

    The technical evolution of extracorporeal membrane oxygenation (ECMO) coincides with the vast improvement in intensive care medicine of the past 4 decades. Extracorporeal circulatory technology substitutes for acutely failed cardiac or pulmonary function until these organs regain sustainable function through goal-oriented intensive care practice. The technology has been validated to improve survival in select patients who would otherwise have 100% mortality. This is by far the most complex life-sustaining technology employed and thus can contribute significant risks such that the decision to institute ECMO requires prompt risk and benefit analysis. Delaying the institution of ECMO may cause irreversible pulmonary and cardiac injuries in addition to other organs. Therefore, the optimal time of initiating ECMO support is crucial to the survival of a critically ill patient.

  7. Optimal Path Determination for Flying Vehicle to Search an Object

    Science.gov (United States)

    Heru Tjahjana, R.; Heri Soelistyo U, R.; Ratnasari, L.; Irawanto, B.

    2018-01-01

    In this paper, a method to determine optimal path for flying vehicle to search an object is proposed. Background of the paper is controlling air vehicle to search an object. Optimal path determination is one of the most popular problem in optimization. This paper describe model of control design for a flying vehicle to search an object, and focus on the optimal path that used to search an object. In this paper, optimal control model is used to control flying vehicle to make the vehicle move in optimal path. If the vehicle move in optimal path, then the path to reach the searched object also optimal. The cost Functional is one of the most important things in optimal control design, in this paper the cost functional make the air vehicle can move as soon as possible to reach the object. The axis reference of flying vehicle uses N-E-D (North-East-Down) coordinate system. The result of this paper are the theorems which say that the cost functional make the control optimal and make the vehicle move in optimal path are proved analytically. The other result of this paper also shows the cost functional which used is convex. The convexity of the cost functional is use for guarantee the existence of optimal control. This paper also expose some simulations to show an optimal path for flying vehicle to search an object. The optimization method which used to find the optimal control and optimal path vehicle in this paper is Pontryagin Minimum Principle.

  8. Method for Determining the Time Parameter

    Directory of Open Access Journals (Sweden)

    K. P. Baslyk

    2014-01-01

    Full Text Available This article proposes a method for calculating one of the characteristics that represents the flight program of the first stage of ballistic rocket i.e. time parameter of the program of attack angle.In simulation of placing the payload for the first stage, a program of flight is used which consists of three segments, namely a vertical climb of the rocket, a segment of programmed reversal by attack angle, and a segment of gravitational reversal with zero angle of attack.The programed reversal by attack angle is simulated as a rapidly decreasing and increasing function. This function depends on the attack angle amplitude, time and time parameter.If the projected and ballistic parameters and the amplitude of attack angle were determined this coefficient is calculated based the constraint that the rocket velocity is equal to 0.8 from the sound velocity (0,264 km/sec when the angle of attack becomes equal to zero. Such constraint is transformed to the nonlinear equation, which can be solved using a Newton method.The attack angle amplitude value is unknown for the design analysis. Exceeding some maximum admissible value for this parameter may lead to excessive trajectory collapsing (foreshortening, which can be identified as an arising negative trajectory angle.Consequently, therefore it is necessary to compute the maximum value of the attack angle amplitude with the following constraints: a trajectory angle is positive during the entire first stage flight and the rocket velocity is equal to 0,264 km/sec by the end of program of angle attack. The problem can be formulated as a task of the nonlinear programming, minimization of the modified Lagrange function, which is solved using the multipliers method.If multipliers and penalty parameter are constant the optimization problem without constraints takes place. Using the determined coordinate descent method allows solving the problem of modified Lagrange function of unconstrained minimization with fixed

  9. Optimal Real-time Dispatch for Integrated Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan Michael [Univ. of California, Berkeley, CA (United States)

    2007-05-31

    This report describes the development and application of a dispatch optimization algorithm for integrated energy systems (IES) comprised of on-site cogeneration of heat and electricity, energy storage devices, and demand response opportunities. This work is intended to aid commercial and industrial sites in making use of modern computing power and optimization algorithms to make informed, near-optimal decisions under significant uncertainty and complex objective functions. The optimization algorithm uses a finite set of randomly generated future scenarios to approximate the true, stochastic future; constraints are included that prevent solutions to this approximate problem from deviating from solutions to the actual problem. The algorithm is then expressed as a mixed integer linear program, to which a powerful commercial solver is applied. A case study of United States Postal Service Processing and Distribution Centers (P&DC) in four cities and under three different electricity tariff structures is conducted to (1) determine the added value of optimal control to a cogeneration system over current, heuristic control strategies; (2) determine the value of limited electric load curtailment opportunities, with and without cogeneration; and (3) determine the trade-off between least-cost and least-carbon operations of a cogeneration system. Key results for the P&DC sites studied include (1) in locations where the average electricity and natural gas prices suggest a marginally profitable cogeneration system, optimal control can add up to 67% to the value of the cogeneration system; optimal control adds less value in locations where cogeneration is more clearly profitable; (2) optimal control under real-time pricing is (a) more complicated than under typical time-of-use tariffs and (b) at times necessary to make cogeneration economic at all; (3) limited electric load curtailment opportunities can be more valuable as a compliment to the cogeneration system than alone; and

  10. Optimizing the search for transiting planets in long time series

    Science.gov (United States)

    Ofir, Aviv

    2014-01-01

    Context. Transit surveys, both ground- and space-based, have already accumulated a large number of light curves that span several years. Aims: The search for transiting planets in these long time series is computationally intensive. We wish to optimize the search for both detection and computational efficiencies. Methods: We assume that the searched systems can be described well by Keplerian orbits. We then propagate the effects of different system parameters to the detection parameters. Results: We show that the frequency information content of the light curve is primarily determined by the duty cycle of the transit signal, and thus the optimal frequency sampling is found to be cubic and not linear. Further optimization is achieved by considering duty-cycle dependent binning of the phased light curve. By using the (standard) BLS, one is either fairly insensitive to long-period planets or less sensitive to short-period planets and computationally slower by a significant factor of ~330 (for a 3 yr long dataset). We also show how the physical system parameters, such as the host star's size and mass, directly affect transit detection. This understanding can then be used to optimize the search for every star individually. Conclusions: By considering Keplerian dynamics explicitly rather than implicitly one can optimally search the BLS parameter space. The presented Optimal BLS enhances the detectability of both very short and very long period planets, while allowing such searches to be done with much reduced resources and time. The Matlab/Octave source code for Optimal BLS is made available. The MATLAB code is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/561/A138

  11. Optimizing near real time accountability for reprocessing

    International Nuclear Information System (INIS)

    Cipiti, Benjamin B.

    2010-01-01

    Near Real Time Accountability (NRTA) of actinides at high precision in reprocessing plants has been a long sought-after goal in the safeguards community. Achieving this goal is hampered by the difficulty of making precision measurements in the reprocessing environment, equipment cost, and impact to plant operations. Thus the design of future reprocessing plants requires an optimization of different approaches. The Separations and Safeguards Performance Model, developed at Sandia National Laboratories, was used to evaluate a number of NRTA strategies in a UREX+ reprocessing plant. Strategies examined include the incorporation of additional actinide measurements of internal plant vessels, more use of process monitoring data, and the option of periodic draining of inventory to key tanks. Preliminary results show that the addition of measurement technologies can increase the overall measurement uncertainty due to additional error propagation, so care must be taken when designing an advanced system. Initial results also show that relying on a combination of different NRTA techniques will likely be the best option. The model provides a platform for integrating all the data. The modeling results for the different NRTA options under various material loss conditions will be presented.

  12. Optimal Time to Invest Energy Storage System under Uncertainty Conditions

    Directory of Open Access Journals (Sweden)

    Yongma Moon

    2014-04-01

    Full Text Available This paper proposes a model to determine the optimal investment time for energy storage systems (ESSs in a price arbitrage trade application under conditions of uncertainty over future profits. The adoption of ESSs can generate profits from price arbitrage trade, which are uncertain because the future marginal prices of electricity will change depending on supply and demand. In addition, since the investment is optional, an investor can delay adopting an ESS until it becomes profitable, and can decide the optimal time. Thus, when we evaluate this investment, we need to incorporate the investor’s option which is not captured by traditional evaluation methods. In order to incorporate these aspects, we applied real option theory to our proposed model, which provides an optimal investment threshold. Our results concerning the optimal time to invest show that if future profits that are expected to be obtained from arbitrage trade become more uncertain, an investor needs to wait longer to invest. Also, improvement in efficiency of ESSs can reduce the uncertainty of arbitrage profit and, consequently, the reduced uncertainty enables earlier ESS investment, even for the same power capacity. Besides, when a higher rate of profits is expected and ESS costs are higher, an investor needs to wait longer. Also, by comparing a widely used net present value model to our real option model, we show that the net present value method underestimates the value for ESS investment and misleads the investor to make an investment earlier.

  13. A Method for Determining Optimal Residential Energy Efficiency Packages

    Energy Technology Data Exchange (ETDEWEB)

    Polly, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gestwick, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bianchi, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Anderson, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Horowitz, S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Christensen, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Judkoff, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2011-04-01

    This report describes an analysis method for determining optimal residential energy efficiency retrofit packages and, as an illustrative example, applies the analysis method to a 1960s-era home in eight U.S. cities covering a range of International Energy Conservation Code (IECC) climate regions. The method uses an optimization scheme that considers average energy use (determined from building energy simulations) and equivalent annual cost to recommend optimal retrofit packages specific to the building, occupants, and location.

  14. Heuristic Optimization Techniques for Determining Optimal Reserve Structure of Power Generating Systems

    DEFF Research Database (Denmark)

    Ding, Yi; Goel, Lalit; Wang, Peng

    2012-01-01

    cost of the system will also increase. The reserve structure of a MSS should be determined based on striking a balance between the required reliability and the reserve cost. The objective of reserve management for a MSS is to schedule the reserve at the minimum system reserve cost while maintaining......Electric power generating systems are typical examples of multi-state systems (MSS). Sufficient reserve is critically important for maintaining generating system reliabilities. The reliability of a system can be increased by increasing the reserve capacity, noting that at the same time the reserve...... the required level of supply reliability to its customers. In previous research, Genetic Algorithm (GA) has been used to solve most reliability optimization problems. However, the GA is not very computationally efficient in some cases. In this chapter a new heuristic optimization technique—the particle swarm...

  15. determination of determination of optimal tilt angle for maximum

    African Journals Online (AJOL)

    eobe

    Keywords: Energy output, photovoltaic module, best tilt angle, solar radiation, sunshine hours, ambient temperature. 1. .... at any given time is vital in the design of a PV system. The solar ..... [8] E. Taymur, Photovoltaic System Sizing [thesis].

  16. Cooling-time determination of spent fuel

    International Nuclear Information System (INIS)

    Hsue, S.T.; Hatcher, C.R.; Kaieda, K.

    1979-01-01

    Two methods to determine the cooling time using data from high-resolution gamma-ray measurements are discussed; one is useful when the irradiation history information is available, the other when the irradiation history is not available. We have applied both methods and found that the cooling time can be determined to within an average of 3% and 4.1%, respectively

  17. Optimizing UV Index determination from broadband irradiances

    Science.gov (United States)

    Tereszchuk, Keith A.; Rochon, Yves J.; McLinden, Chris A.; Vaillancourt, Paul A.

    2018-03-01

    A study was undertaken to improve upon the prognosticative capability of Environment and Climate Change Canada's (ECCC) UV Index forecast model. An aspect of that work, and the topic of this communication, was to investigate the use of the four UV broadband surface irradiance fields generated by ECCC's Global Environmental Multiscale (GEM) numerical prediction model to determine the UV Index. The basis of the investigation involves the creation of a suite of routines which employ high-spectral-resolution radiative transfer code developed to calculate UV Index fields from GEM forecasts. These routines employ a modified version of the Cloud-J v7.4 radiative transfer model, which integrates GEM output to produce high-spectral-resolution surface irradiance fields. The output generated using the high-resolution radiative transfer code served to verify and calibrate GEM broadband surface irradiances under clear-sky conditions and their use in providing the UV Index. A subsequent comparison of irradiances and UV Index under cloudy conditions was also performed. Linear correlation agreement of surface irradiances from the two models for each of the two higher UV bands covering 310.70-330.0 and 330.03-400.00 nm is typically greater than 95 % for clear-sky conditions with associated root-mean-square relative errors of 6.4 and 4.0 %. However, underestimations of clear-sky GEM irradiances were found on the order of ˜ 30-50 % for the 294.12-310.70 nm band and by a factor of ˜ 30 for the 280.11-294.12 nm band. This underestimation can be significant for UV Index determination but would not impact weather forecasting. Corresponding empirical adjustments were applied to the broadband irradiances now giving a correlation coefficient of unity. From these, a least-squares fitting was derived for the calculation of the UV Index. The resultant differences in UV indices from the high-spectral-resolution irradiances and the resultant GEM broadband irradiances are typically within 0

  18. Simulation-based robust optimization for signal timing and setting.

    Science.gov (United States)

    2009-12-30

    The performance of signal timing plans obtained from traditional approaches for : pre-timed (fixed-time or actuated) control systems is often unstable under fluctuating traffic : conditions. This report develops a general approach for optimizing the ...

  19. Optimal time travel in the Godel universe

    OpenAIRE

    Natario, Jose

    2011-01-01

    Using the theory of optimal rocket trajectories in general relativity, recently developed in arXiv:1105.5235, we present a candidate for the minimum total integrated acceleration closed timelike curve in the Godel universe, and give evidence for its minimality. The total integrated acceleration of this curve is lower than Malament's conjectured value (Malament, 1984), as was already implicit in the work of Manchak (Manchak, 2011); however, Malament's conjecture does seem to hold for periodic ...

  20. The State Fiscal Policy: Determinants and Optimization of Financial Flows

    Directory of Open Access Journals (Sweden)

    Sitash Tetiana D.

    2017-03-01

    Full Text Available The article outlines the determinants of the state fiscal policy at the present stage of global transformations. Using the principles of financial science it is determined that regulation of financial flows within the fiscal sphere, namely centralization and redistribution of the GDP, which results in the regulation of the financial capacity of economic agents, is of importance. It is emphasized that the urgent measure for improving the tax model is re-considering the provision of fiscal incentives, which are used to stimulate the accumulation of capital, investment activity, innovation, increase of the competitiveness of national products, expansion of exports, increase of the level of the population employment. The necessity of applying the instruments of fiscal regulation of financial flows, which should take place on the basis of institutional economics emphasizing the analysis of institutional changes, the evolution of institutions and their impact on the behavior of participants of economic relations. At the same time it is determined that the maximum effect of fiscal regulation of financial flows is ensured when application of fiscal instruments is aimed not only at achieving the target values of parameters of financial flows but at overcoming institutional deformations as well. It is determined that the optimal movement of financial flows enables creating favorable conditions for development and maintenance of financial balance in the society and achievement of the necessary level of competitiveness of the national economy.

  1. Optimal Cotton Insecticide Application Termination Timing: A Meta-Analysis.

    Science.gov (United States)

    Griffin, T W; Zapata, S D

    2016-08-01

    The concept of insecticide termination timing is generally accepted among cotton (Gossypium hirsutum) researchers; however, exact timings are often disputed. Specifically, there is uncertainty regarding the last economic insecticide application to control fruit-feeding pests including tarnished plant bug (Lygus lineolaris (Palisot de Beauvois)), boll weevil (Anthonomus grandis), bollworm (Helicoverpa zea), tobacco budworm (Heliothis virescens), and cotton fleahopper (Pseudatomoscelis seriatus). A systematic review of prior studies was conducted within a meta-analytic framework. Nine publicly available articles were amalgamated to develop an optimal timing principle. These prior studies reported 53 independent multiple means comparison field experiments for a total of 247 trial observations. Stochastic plateau theory integrated with econometric meta-analysis methodology was applied to the meta-database to determine the shape of the functional form of both the agronomic optimal insecticide termination timing and corresponding yield potential. Results indicated that current university insecticide termination timing recommendations are later than overall estimated timing suggested. The estimated 159 heat units (HU) after the fifth position above white flower (NAWF5) was found to be statistically different than the 194 HU termination used as the status quo recommended termination timing. Insecticides applied after 159 HU may have been applied in excess, resulting in unnecessary economic and environmental costs. Empirical results also suggested that extending the insecticide termination time by one unit resulted in a cotton lint yield increase of 0.27 kilograms per hectare up to the timing where the plateau began. Based on economic analyses, profit-maximizing producers may cease application as soon as 124 HU after NAWF5. These results provided insights useful to improve production systems by applying inputs only when benefits were expected to be in excess of the

  2. Novel Verification Method for Timing Optimization Based on DPSO

    Directory of Open Access Journals (Sweden)

    Chuandong Chen

    2018-01-01

    Full Text Available Timing optimization for logic circuits is one of the key steps in logic synthesis. Extant research data are mainly proposed based on various intelligence algorithms. Hence, they are neither comparable with timing optimization data collected by the mainstream electronic design automation (EDA tool nor able to verify the superiority of intelligence algorithms to the EDA tool in terms of optimization ability. To address these shortcomings, a novel verification method is proposed in this study. First, a discrete particle swarm optimization (DPSO algorithm was applied to optimize the timing of the mixed polarity Reed-Muller (MPRM logic circuit. Second, the Design Compiler (DC algorithm was used to optimize the timing of the same MPRM logic circuit through special settings and constraints. Finally, the timing optimization results of the two algorithms were compared based on MCNC benchmark circuits. The timing optimization results obtained using DPSO are compared with those obtained from DC, and DPSO demonstrates an average reduction of 9.7% in the timing delays of critical paths for a number of MCNC benchmark circuits. The proposed verification method directly ascertains whether the intelligence algorithm has a better timing optimization ability than DC.

  3. Determination of detection equipment dead time

    International Nuclear Information System (INIS)

    Sacha, J.

    1980-01-01

    A method is described of determining dead time by short-lived source measurement. It is based on measuring the sample count rates in different time intervals when only dead time correction is changed with the changing count of recorded pulses. The dead time may be determined from the measured values by a numerical-graphical method. The method is described. The advantage of the method is the minimization of errors and inaccuracies; the disadvantage is that the half-life of the source used should very accurately be known. (J.P.)

  4. OPTIMAL GUARANTEED SERVICES TIMED TOKEN (OGSTT ...

    African Journals Online (AJOL)

    eobe

    transmission time, as required by the hard real-time tasks, but also high ... The network and message models are presented in ... node has a unique number in the range 0, 1, 2…N-1. For each .... To overcome this, an integer U is added to the ...

  5. Time is on my side: optimism in intertemporal choice

    NARCIS (Netherlands)

    Berndsen, M.; van der Pligt, J.

    2001-01-01

    The present research, using data from 163 undergraduates, examines the role of optimism on time preferences for both losses and gains. It is argued that optimism has asymmetric effects on time preferences for gains versus losses: one reason why decision makers prefer immediate gains is because they

  6. On the application of Discrete Time Optimal Control Concepts to ...

    African Journals Online (AJOL)

    On the application of Discrete Time Optimal Control Concepts to Economic Problems. ... Journal of the Nigerian Association of Mathematical Physics ... Abstract. An extension of the use of the maximum principle to solve Discrete-time Optimal Control Problems (DTOCP), in which the state equations are in the form of general ...

  7. Computer-determined assay time based on preset precision

    International Nuclear Information System (INIS)

    Foster, L.A.; Hagan, R.; Martin, E.R.; Wachter, J.R.; Bonner, C.A.; Malcom, J.E.

    1994-01-01

    Most current assay systems for special nuclear materials (SNM) operate on the principle of a fixed assay time which provides acceptable measurement precision without sacrificing the required throughput of the instrument. Waste items to be assayed for SNM content can contain a wide range of nuclear material. Counting all items for the same preset assay time results in a wide range of measurement precision and wastes time at the upper end of the calibration range. A short time sample taken at the beginning of the assay could optimize the analysis time on the basis of the required measurement precision. To illustrate the technique of automatically determining the assay time, measurements were made with a segmented gamma scanner at the Plutonium Facility of Los Alamos National Laboratory with the assay time for each segment determined by counting statistics in that segment. Segments with very little SNM were quickly determined to be below the lower limit of the measurement range and the measurement was stopped. Segments with significant SNM were optimally assays to the preset precision. With this method the total assay time for each item is determined by the desired preset precision. This report describes the precision-based algorithm and presents the results of measurements made to test its validity

  8. Optimal Robust Fault Detection for Linear Discrete Time Systems

    Directory of Open Access Journals (Sweden)

    Nike Liu

    2008-01-01

    Full Text Available This paper considers robust fault-detection problems for linear discrete time systems. It is shown that the optimal robust detection filters for several well-recognized robust fault-detection problems, such as ℋ−/ℋ∞, ℋ2/ℋ∞, and ℋ∞/ℋ∞ problems, are the same and can be obtained by solving a standard algebraic Riccati equation. Optimal filters are also derived for many other optimization criteria and it is shown that some well-studied and seeming-sensible optimization criteria for fault-detection filter design could lead to (optimal but useless fault-detection filters.

  9. Discrete-time optimal control and games on large intervals

    CERN Document Server

    Zaslavski, Alexander J

    2017-01-01

    Devoted to the structure of approximate solutions of discrete-time optimal control problems and approximate solutions of dynamic discrete-time two-player zero-sum games, this book presents results on properties of approximate solutions in an interval that is independent lengthwise, for all sufficiently large intervals. Results concerning the so-called turnpike property of optimal control problems and zero-sum games in the regions close to the endpoints of the time intervals are the main focus of this book. The description of the structure of approximate solutions on sufficiently large intervals and its stability will interest graduate students and mathematicians in optimal control and game theory, engineering, and economics. This book begins with a brief overview and moves on to analyze the structure of approximate solutions of autonomous nonconcave discrete-time optimal control Lagrange problems.Next the structures of approximate solutions of autonomous discrete-time optimal control problems that are discret...

  10. Method for Determining Optimal Residential Energy Efficiency Retrofit Packages

    Energy Technology Data Exchange (ETDEWEB)

    Polly, B.; Gestwick, M.; Bianchi, M.; Anderson, R.; Horowitz, S.; Christensen, C.; Judkoff, R.

    2011-04-01

    Businesses, government agencies, consumers, policy makers, and utilities currently have limited access to occupant-, building-, and location-specific recommendations for optimal energy retrofit packages, as defined by estimated costs and energy savings. This report describes an analysis method for determining optimal residential energy efficiency retrofit packages and, as an illustrative example, applies the analysis method to a 1960s-era home in eight U.S. cities covering a range of International Energy Conservation Code (IECC) climate regions. The method uses an optimization scheme that considers average energy use (determined from building energy simulations) and equivalent annual cost to recommend optimal retrofit packages specific to the building, occupants, and location. Energy savings and incremental costs are calculated relative to a minimum upgrade reference scenario, which accounts for efficiency upgrades that would occur in the absence of a retrofit because of equipment wear-out and replacement with current minimum standards.

  11. Solar sail time-optimal interplanetary transfer trajectory design

    International Nuclear Information System (INIS)

    Gong Shengpin; Gao Yunfeng; Li Junfeng

    2011-01-01

    The fuel consumption associated with some interplanetary transfer trajectories using chemical propulsion is not affordable. A solar sail is a method of propulsion that does not consume fuel. Transfer time is one of the most pressing problems of solar sail transfer trajectory design. This paper investigates the time-optimal interplanetary transfer trajectories to a circular orbit of given inclination and radius. The optimal control law is derived from the principle of maximization. An indirect method is used to solve the optimal control problem by selecting values for the initial adjoint variables, which are normalized within a unit sphere. The conditions for the existence of the time-optimal transfer are dependent on the lightness number of the sail and the inclination and radius of the target orbit. A numerical method is used to obtain the boundary values for the time-optimal transfer trajectories. For the cases where no time-optimal transfer trajectories exist, first-order necessary conditions of the optimal control are proposed to obtain feasible solutions. The results show that the transfer time decreases as the minimum distance from the Sun decreases during the transfer duration. For a solar sail with a small lightness number, the transfer time may be evaluated analytically for a three-phase transfer trajectory. The analytical results are compared with previous results and the associated numerical results. The transfer time of the numerical result here is smaller than the transfer time from previous results and is larger than the analytical result.

  12. On the Determination of Proper Time

    OpenAIRE

    Hurl, Bing; Zhang, Zhi-Yong Wang Hai-Dong

    1998-01-01

    Through the analysis of the definition of the duration of proper time of a particle given by the length of its world line, we show that there is no transitivity of the coordinate time function derived from the definition, so there exists an ambiguity in the determination of the duration of the proper time for the particle. Its physical consequence is illustrated with quantum measurement effect.

  13. Engineering applications of discrete-time optimal control

    DEFF Research Database (Denmark)

    Vidal, Rene Victor Valqui; Ravn, Hans V.

    1990-01-01

    Many problems of design and operation of engineering systems can be formulated as optimal control problems where time has been discretisized. This is also true even if 'time' is not involved in the formulation of the problem, but rather another one-dimensional parameter. This paper gives a review...... of some well-known and new results in discrete time optimal control methods applicable to practical problem solving within engineering. Emphasis is placed on dynamic programming, the classical maximum principle and generalized versions of the maximum principle for optimal control of discrete time systems...

  14. Optimal timing for intravenous administration set replacement.

    Science.gov (United States)

    Gillies, D; O'Riordan, L; Wallen, M; Morrison, A; Rankin, K; Nagy, S

    2005-10-19

    Administration of intravenous therapy is a common occurrence within the hospital setting. Routine replacement of administration sets has been advocated to reduce intravenous infusion contamination. If decreasing the frequency of changing intravenous administration sets does not increase infection rates, a change in practice could result in considerable cost savings. The objective of this review was to identify the optimal interval for the routine replacement of intravenous administration sets when infusate or parenteral nutrition (lipid and non-lipid) solutions are administered to people in hospital via central or peripheral venous catheters. We searched The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, CINAHL, EMBASE: all from inception to February 2004; reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. We did not have a language restriction. We included all randomized or quasi-randomized controlled trials addressing the frequency of replacing intravenous administration sets when parenteral nutrition (lipid and non-lipid containing solutions) or infusions (excluding blood) were administered to people in hospital via a central or peripheral catheter. Two authors assessed all potentially relevant studies. We resolved disagreements between the two authors by discussion with a third author. We collected data for the outcomes; infusate contamination; infusate-related bloodstream infection; catheter contamination; catheter-related bloodstream infection; all-cause bloodstream infection and all-cause mortality. We identified 23 references for review. We excluded eight of these studies; five because they did not fit the inclusion criteria and three because of inadequate data. We extracted data from the remaining 15 references (13 studies) with 4783 participants. We conclude that there is no evidence that changing intravenous administration sets more often than every 96 hours

  15. Analysis and Optimization of Heterogeneous Real-Time Embedded Systems

    DEFF Research Database (Denmark)

    Pop, Paul; Eles, Petru; Peng, Zebo

    2005-01-01

    . The success of such new design methods depends on the availability of analysis and optimization techniques. In this paper, we present analysis and optimization techniques for heterogeneous real-time embedded systems. We address in more detail a particular class of such systems called multi-clusters, composed...... to frames. Optimization heuristics for frame packing aiming at producing a schedulable system are presented. Extensive experiments and a real-life example show the efficiency of the frame-packing approach....

  16. Optimal Infinite Runs in One-Clock Priced Timed Automata

    DEFF Research Database (Denmark)

    David, Alexandre; Ejsing-Duun, Daniel; Fontani, Lisa

    We address the problem of finding an infinite run with the optimal cost-time ratio in a one-clock priced timed automaton and pro- vide an algorithmic solution. Through refinements of the quotient graph obtained by strong time-abstracting bisimulation partitioning, we con- struct a graph with time...

  17. Methods for determining time of death.

    Science.gov (United States)

    Madea, Burkhard

    2016-12-01

    Medicolegal death time estimation must estimate the time since death reliably. Reliability can only be provided empirically by statistical analysis of errors in field studies. Determining the time since death requires the calculation of measurable data along a time-dependent curve back to the starting point. Various methods are used to estimate the time since death. The current gold standard for death time estimation is a previously established nomogram method based on the two-exponential model of body cooling. Great experimental and practical achievements have been realized using this nomogram method. To reduce the margin of error of the nomogram method, a compound method was developed based on electrical and mechanical excitability of skeletal muscle, pharmacological excitability of the iris, rigor mortis, and postmortem lividity. Further increasing the accuracy of death time estimation involves the development of conditional probability distributions for death time estimation based on the compound method. Although many studies have evaluated chemical methods of death time estimation, such methods play a marginal role in daily forensic practice. However, increased precision of death time estimation has recently been achieved by considering various influencing factors (i.e., preexisting diseases, duration of terminal episode, and ambient temperature). Putrefactive changes may be used for death time estimation in water-immersed bodies. Furthermore, recently developed technologies, such as H magnetic resonance spectroscopy, can be used to quantitatively study decompositional changes. This review addresses the gold standard method of death time estimation in forensic practice and promising technological and scientific developments in the field.

  18. Discount-Optimal Infinite Runs in Priced Timed Automata

    DEFF Research Database (Denmark)

    Fahrenberg, Uli; Larsen, Kim Guldstrand

    2009-01-01

    We introduce a new discounting semantics for priced timed automata. Discounting provides a way to model optimal-cost problems for infinite traces and has applications in optimal scheduling and other areas. In the discounting semantics, prices decrease exponentially, so that the contribution...

  19. FAME Storage Time in an Optimized Natural Antioxidant Mixture

    Directory of Open Access Journals (Sweden)

    Rodolfo Lopes Coppo

    2013-01-01

    Full Text Available The study of B100 biodiesel oxidation stability, and its conservation, is extremely important to control its quality, especially regarding storage. Many spices have shown antioxidant effect and are the targets of study. Knowing the oxidation process in greater detail allows a reliable storage period to be stipulated for the biodiesel without its degradation until the time of use. Results have shown that according to the accelerated stove method, the optimal mixture, composed of 100% of oregano extract, can confer a 535-day shelf life to biodiesel without evident oxidation. According to the results obtained by the Rancimat method, the ideal mixture consists of 100% rosemary, resulting in 483 days of storage. The application of the process variable showed that the accelerated stove method was more suitable to determine oxidative stability of biodiesel.

  20. Optimal timing for intravascular administration set replacement.

    Science.gov (United States)

    Ullman, Amanda J; Cooke, Marie L; Gillies, Donna; Marsh, Nicole M; Daud, Azlina; McGrail, Matthew R; O'Riordan, Elizabeth; Rickard, Claire M

    2013-09-15

    populations, arterial and venous administration sets, parenteral nutrition, lipid emulsions and crystalloid infusions. Most studies were at moderate to high risk of bias or did not adequately describe the methods that they used to minimize bias. All included trials were unable to blind personnel because of the nature of the intervention.No evidence was found for differences in catheter-related or infusate-related bacteraemia or fungaemia with more frequent administration set replacement overall or at any time interval comparison (risk ratio (RR) 1.06, 95% confidence interval (CI) 0.67 to 1.69; RR 0.67, 95% CI 0.27 to 1.70). Infrequent administration set replacement reduced the rate of bloodstream infection (RR 0.73, 95% CI 0.54 to 0.98). No evidence revealed differences in catheter colonization or infusate colonization with more frequent administration set replacement (RR 1.08, 95% CI 0.94 to 1.24; RR 1.15, 95% CI 0.70 to 1.86, respectively). Borderline evidence suggested that infrequent administration set replacement increased the mortality rate only within the neonatal population (RR 1.84, 95% CI 1.00 to 3.36). No evidence revealed interactions between the (lack of) effects of frequency of administration set replacement and the subgroups analysed: parenteral nutrition and/or fat emulsions versus infusates not involving parenteral nutrition or fat emulsions; adult versus neonatal participants; and arterial versus venous catheters. Some evidence indicates that administration sets that do not contain lipids, blood or blood products may be left in place for intervals of up to 96 hours without increasing the risk of infection. Other evidence suggests that mortality increased within the neonatal population with infrequent administration set replacement. However, much the evidence obtained was derived from studies of low to moderate quality.

  1. Optimal timing of tracheostomy after trauma without associated head injury.

    Science.gov (United States)

    Keenan, Jeffrey E; Gulack, Brian C; Nussbaum, Daniel P; Green, Cindy L; Vaslef, Steven N; Shapiro, Mark L; Scarborough, John E

    2015-10-01

    Controversy exists over optimal timing of tracheostomy in patients with respiratory failure after blunt trauma. The study aimed to determine whether the timing of tracheostomy affects mortality in this population. The 2008-2011 National Trauma Data Bank was queried to identify blunt trauma patients without concomitant head injury who required tracheostomy for respiratory failure between hospital days 4 and 21. Restricted cubic spline analysis was performed to evaluate the relationship between tracheostomy timing and the odds of inhospital mortality. The cohort was stratified based on this analysis. Unadjusted characteristics and outcomes were compared. Multivariable logistic regression was used to evaluate the effect of tracheostomy timing on mortality after adjustment for age, gender, race, payor status, level of trauma center, injury severity score, presentation Glasgow coma scale, and thoracic and abdominal abbreviated injury score. There were 9662 patients included in the study. Restricted cubic spline analysis demonstrated a nonlinear relationship between timing of tracheostomy and mortality, with higher odds of mortality occurring with tracheostomy placement within 10 d of admission compared with later time points. The cohort was therefore stratified into early and delayed tracheostomy groups relative to this time point. The resulting groups contained 5402 (55.9%) and 4260 (44.1%) patients, respectively. After multivariable adjustment, the delayed tracheostomy group continued to have significantly reduced odds of mortality (Adjusted odds ratio, 0.82, 95% confidence interval, 0.71-0.95, C-statistic, 0.700). Among non-head injured blunt trauma patients with prolonged respiratory failure, tracheostomy placement within 10 d of admission may result in increased mortality compared with later time points. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Determination of operation time function for activimeters

    International Nuclear Information System (INIS)

    Sousa, C.H.S.; Peixoto, J.G.P.; Araujo, G.; Padilha, L.G.

    2016-01-01

    Radiation detectors must pass periodically recommended quality control tests and standardized to certify the quality of measurements, however, many studies have shown that several parameters can influence the results, however, some instrument components that can not be adjusted during calibrations may have significant importance in measurement results over the operating time. This study sought to determine the influence of the use of time in the activity measurements. The results show a trend of decreased activity measured for equipment with detectors with more operating time. (author)

  3. Statistically defining optimal conditions of coagulation time of skim milk

    International Nuclear Information System (INIS)

    Celebi, M.; Ozdemir, Z.O.; Eroglu, E.; Guney, I

    2014-01-01

    Milk consist huge amount of largely water and different proteins. Kappa-kazein of these milk proteins can be coagulated by Mucor miehei rennet enzyme, is an aspartic protease which cleavege 105 (phenly alanine)-106 (methionine) peptide bond. It is commonly used clotting milk proteins for cheese production in dairy industry. The aim of this study to measure milk clotting times of skim milk by using Mucor Miehei rennet and determination of optimal conditions of milk clotting time by mathematical modelling. In this research, milk clotting times of skim milk were measured at different pHs (3.0, 4.0, 5.0, 6.0, 7.0, 8.0) and temperatures (20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75 degree C). It was used statistical approach for defining best pH and temperature for milk clotting time of skim milk. Milk clotting activity was increase at acidic pHs and high temperatures. (author)

  4. Identification of optimal inspection interval via delay-time concept

    Directory of Open Access Journals (Sweden)

    Glauco Ricardo Simões Gomes

    2016-06-01

    Full Text Available This paper presents an application of mathematical modeling aimed at managing maintenance based on the delay-time concept. The study scenario was the manufacturing sector of an industrial unit, which operates 24 hours a day in a continuous flow of production. The main idea was to use the concepts of this approach to determine the optimal time of preventive action by the maintenance department in order to ensure the greatest availability of equipment and facilities at appropriate maintenance costs. After a brief introduction of the subject, the article presents topics that illustrate the importance of mathematical modeling in maintenance management and the delay-time concept. It also describes the characteristics of the company where the study was conducted, as well as the data related to the production process and maintenance actions. Finally, the results obtained after applying the delay-time concept are presented and discussed, as well as the limitations of the article and the proposals for future research.

  5. Determining the optimal spacing of deepening of vertical mine

    Energy Technology Data Exchange (ETDEWEB)

    Durov, Ye.M.

    1983-01-01

    Light is shed on a technique for determining the optimal spacing of shafts for deepening for the examined parameters of operational and deepening operations. The presented results of studies may be used in designing new shafts, in preparing levels and in reconstruction of existing shafts with slanted and steep stratum bedding.

  6. Problems in determining the optimal use of road safety measures

    DEFF Research Database (Denmark)

    Elvik, Rune

    2014-01-01

    for intervention that ensures maximum safety benefits. The third problem is how to develop policy options to minimise the risk of indivisibilities and irreversible choices. The fourth problem is how to account for interaction effects between road safety measures when determining their optimal use. The fifth......This paper discusses some problems in determining the optimal use of road safety measures. The first of these problems is how best to define the baseline option, i.e. what will happen if no new safety measures are introduced. The second problem concerns choice of a method for selection of targets...... problem is how to obtain the best mix of short-term and long-term measures in a safety programme. The sixth problem is how fixed parameters for analysis, including the monetary valuation of road safety, influence the results of analyses. It is concluded that it is at present not possible to determine...

  7. Optimal Time-Abstract Schedulers for CTMDPs and Markov Games

    Directory of Open Access Journals (Sweden)

    Markus Rabe

    2010-06-01

    Full Text Available We study time-bounded reachability in continuous-time Markov decision processes for time-abstract scheduler classes. Such reachability problems play a paramount role in dependability analysis and the modelling of manufacturing and queueing systems. Consequently, their analysis has been studied intensively, and techniques for the approximation of optimal control are well understood. From a mathematical point of view, however, the question of approximation is secondary compared to the fundamental question whether or not optimal control exists. We demonstrate the existence of optimal schedulers for the time-abstract scheduler classes for all CTMDPs. Our proof is constructive: We show how to compute optimal time-abstract strategies with finite memory. It turns out that these optimal schedulers have an amazingly simple structure---they converge to an easy-to-compute memoryless scheduling policy after a finite number of steps. Finally, we show that our argument can easily be lifted to Markov games: We show that both players have a likewise simple optimal strategy in these more general structures.

  8. Time-optimal feedback control for linear systems

    International Nuclear Information System (INIS)

    Mirica, S.

    1976-01-01

    The paper deals with the results of qualitative investigations of the time-optimal feedback control for linear systems with constant coefficients. In the first section, after some definitions and notations, two examples are given and it is shown that even the time-optimal control problem for linear systems with constant coefficients which looked like ''completely solved'' requires a further qualitative investigation of the stability to ''permanent perturbations'' of optimal feedback control. In the second section some basic results of the linear time-optimal control problem are reviewed. The third section deals with the definition of Boltyanskii's ''regular synthesis'' and its connection to Filippov's theory of right-hand side discontinuous differential equations. In the fourth section a theorem is proved concerning the stability to perturbations of time-optimal feedback control for linear systems with scalar control. In the last two sections it is proved that, if the matrix which defines the system has only real eigenvalues or is three-dimensional, the time-optimal feedback control defines a regular synthesis and therefore is stable to perturbations. (author)

  9. Determinization of timed Petri nets behaviors

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Lahaye, S.; Boimond, J.-L.

    2016-01-01

    Roč. 26, č. 3 (2016), s. 413-437 ISSN 0924-6703 R&D Projects: GA MŠk LH13012; GA ČR GA15-02532S Institutional support: RVO:67985840 Keywords : timed Petri nets * (max,+) automata * determinization Subject RIV: BA - General Mathematics Impact factor: 1.660, year: 2016 http://link.springer.com/article/10.1007%2Fs10626-015-0214-1

  10. Energy group structure determination using particle swarm optimization

    International Nuclear Information System (INIS)

    Yi, Ce; Sjoden, Glenn

    2013-01-01

    Highlights: ► Particle swarm optimization is applied to determine broad group structure. ► A graph representation of the broad group structure problem is introduced. ► The approach is tested on a fuel-pin model. - Abstract: Multi-group theory is widely applied for the energy domain discretization when solving the Linear Boltzmann Equation. To reduce the computational cost, fine group cross libraries are often down-sampled into broad group cross section libraries. Cross section data collapsing generally involves two steps: Firstly, the broad group structure has to be determined; secondly, a weighting scheme is used to evaluate the broad cross section library based on the fine group cross section data and the broad group structure. A common scheme is to average the fine group cross section weighted by the fine group flux. Cross section collapsing techniques have been intensively researched. However, most studies use a pre-determined group structure, open based on experience, to divide the neutron energy spectrum into thermal, epi-thermal, fast, etc. energy range. In this paper, a swarm intelligence algorithm, particle swarm optimization (PSO), is applied to optimize the broad group structure. A graph representation of the broad group structure determination problem is introduced. And the swarm intelligence algorithm is used to solve the graph model. The effectiveness of the approach is demonstrated using a fuel-pin model

  11. Integrals of Motion for Discrete-Time Optimal Control Problems

    OpenAIRE

    Torres, Delfim F. M.

    2003-01-01

    We obtain a discrete time analog of E. Noether's theorem in Optimal Control, asserting that integrals of motion associated to the discrete time Pontryagin Maximum Principle can be computed from the quasi-invariance properties of the discrete time Lagrangian and discrete time control system. As corollaries, results for first-order and higher-order discrete problems of the calculus of variations are obtained.

  12. Time dependent optimal switching controls in online selling models

    Energy Technology Data Exchange (ETDEWEB)

    Bradonjic, Milan [Los Alamos National Laboratory; Cohen, Albert [MICHIGAN STATE UNIV

    2010-01-01

    We present a method to incorporate dishonesty in online selling via a stochastic optimal control problem. In our framework, the seller wishes to maximize her average wealth level W at a fixed time T of her choosing. The corresponding Hamilton-Jacobi-Bellmann (HJB) equation is analyzed for a basic case. For more general models, the admissible control set is restricted to a jump process that switches between extreme values. We propose a new approach, where the optimal control problem is reduced to a multivariable optimization problem.

  13. Optimal control for parabolic-hyperbolic system with time delay

    International Nuclear Information System (INIS)

    Kowalewski, A.

    1985-07-01

    In this paper we consider an optimal control problem for a system described by a linear partial differential equation of the parabolic-hyperbolic type with time delay in the state. The right-hand side of this equation and the initial conditions are not continuous functions usually, but they are measurable functions belonging to L 2 or Lsup(infinity) spaces. Therefore, the solution of this equation is given by a certain Sobolev space. The time delay in the state is constant, but it can be also a function of time. The control time T is fixed in our problem. Making use of the Milutin-Dubovicki theorem, necessary and sufficient conditions of optimality with the quadratic performance functional and constrained control are derived for the Dirichlet problem. The flow chart of the algorithm which can be used in the numerical solving of certain optimization problems for distributed systems is also presented. (author)

  14. Discrete-time inverse optimal control for nonlinear systems

    CERN Document Server

    Sanchez, Edgar N

    2013-01-01

    Discrete-Time Inverse Optimal Control for Nonlinear Systems proposes a novel inverse optimal control scheme for stabilization and trajectory tracking of discrete-time nonlinear systems. This avoids the need to solve the associated Hamilton-Jacobi-Bellman equation and minimizes a cost functional, resulting in a more efficient controller. Design More Efficient Controllers for Stabilization and Trajectory Tracking of Discrete-Time Nonlinear Systems The book presents two approaches for controller synthesis: the first based on passivity theory and the second on a control Lyapunov function (CLF). Th

  15. An Optimization Framework for Dynamic, Distributed Real-Time Systems

    Science.gov (United States)

    Eckert, Klaus; Juedes, David; Welch, Lonnie; Chelberg, David; Bruggerman, Carl; Drews, Frank; Fleeman, David; Parrott, David; Pfarr, Barbara

    2003-01-01

    Abstract. This paper presents a model that is useful for developing resource allocation algorithms for distributed real-time systems .that operate in dynamic environments. Interesting aspects of the model include dynamic environments, utility and service levels, which provide a means for graceful degradation in resource-constrained situations and support optimization of the allocation of resources. The paper also provides an allocation algorithm that illustrates how to use the model for producing feasible, optimal resource allocations.

  16. Particle swarm optimization for determining shortest distance to voltage collapse

    Energy Technology Data Exchange (ETDEWEB)

    Arya, L.D.; Choube, S.C. [Electrical Engineering Department, S.G.S.I.T.S. Indore, MP 452 003 (India); Shrivastava, M. [Electrical Engineering Department, Government Engineering College Ujjain, MP 456 010 (India); Kothari, D.P. [Centre for Energy Studies, Indian Institute of Technology, Delhi (India)

    2007-12-15

    This paper describes an algorithm for computing shortest distance to voltage collapse or determination of CSNBP using PSO technique. A direction along CSNBP gives conservative results from voltage security view point. This information is useful to the operator to steer the system away from this point by taking corrective actions. The distance to a closest bifurcation is a minimum of the loadability given a slack bus or participation factors for increasing generation as the load increases. CSNBP determination has been formulated as an optimization problem to be used in PSO technique. PSO is a new evolutionary algorithm (EA) which is population based inspired by the social behavior of animals such as fish schooling and birds flocking. It can handle optimization problems with any complexity since mechanization is simple with few parameters to be tuned. The developed algorithm has been implemented on two standard test systems. (author)

  17. On using priced timed automata to achieve optimal scheduling

    DEFF Research Database (Denmark)

    Rasmussen, Jacob Illum; Larsen, Kim Guldstrand; Subramani, K.

    2006-01-01

    This contribution reports on the considerable effort made recently towards extending and applying well-established timed automata technology to optimal scheduling and planning problems. The effort of the authors in this direction has to a large extent been carried out as part of the European proj...... of so-called priced timed automata....

  18. METHODS FOR DETERMINATION AND OPTIMIZATION OF LOGISTICS COSTS

    Directory of Open Access Journals (Sweden)

    Mihaela STET

    2016-12-01

    Full Text Available The paper is dealing with the problems of logistics costs, highlighting some methods for estimation and determination of specific costs for different transport modes in freight distribution. There are highlighted, besides costs of transports, the other costs in supply chain, as well as costing methods used in logistics activities. In this context, there are also revealed some optimization means of transport costs in logistics chain.

  19. METHODS FOR DETERMINATION AND OPTIMIZATION OF LOGISTICS COSTS

    OpenAIRE

    Mihaela STET

    2016-01-01

    The paper is dealing with the problems of logistics costs, highlighting some methods for estimation and determination of specific costs for different transport modes in freight distribution. There are highlighted, besides costs of transports, the other costs in supply chain, as well as costing methods used in logistics activities. In this context, there are also revealed some optimization means of transport costs in logistics chain.

  20. Time-optimal control of infinite order distributed parabolic systems involving time lags

    Directory of Open Access Journals (Sweden)

    G.M. Bahaa

    2014-06-01

    Full Text Available A time-optimal control problem for linear infinite order distributed parabolic systems involving constant time lags appear both in the state equation and in the boundary condition is presented. Some particular properties of the optimal control are discussed.

  1. Optimization of recurrent neural networks for time series modeling

    DEFF Research Database (Denmark)

    Pedersen, Morten With

    1997-01-01

    The present thesis is about optimization of recurrent neural networks applied to time series modeling. In particular is considered fully recurrent networks working from only a single external input, one layer of nonlinear hidden units and a li near output unit applied to prediction of discrete time...... series. The overall objective s are to improve training by application of second-order methods and to improve generalization ability by architecture optimization accomplished by pruning. The major topics covered in the thesis are: 1. The problem of training recurrent networks is analyzed from a numerical...... of solution obtained as well as computation time required. 3. A theoretical definition of the generalization error for recurrent networks is provided. This definition justifies a commonly adopted approach for estimating generalization ability. 4. The viability of pruning recurrent networks by the Optimal...

  2. Determining Optimal Replacement Policy with an Availability Constraint via Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Shengliang Zong

    2017-01-01

    Full Text Available We develop a model and a genetic algorithm for determining an optimal replacement policy for power equipment subject to Poisson shocks. If the time interval of two consecutive shocks is less than a threshold value, the failed equipment can be repaired. We assume that the operating time after repair is stochastically nonincreasing and the repair time is exponentially distributed with a geometric increasing mean. Our objective is to minimize the expected average cost under an availability requirement. Based on this average cost function, we propose the genetic algorithm to locate the optimal replacement policy N to minimize the average cost rate. The results show that the GA is effective and efficient in finding the optimal solutions. The availability of equipment has significance effect on the optimal replacement policy. Many practical systems fit the model developed in this paper.

  3. Optimal time policy for deteriorating items of two-warehouse

    Indian Academy of Sciences (India)

    ... goods in which the first is rented warehouse and the second is own warehouse that deteriorates with two different rates. The aim of this study is to determine the optimal order quantity to maximize the profit of the projected model. Finally, some numerical examples and sensitivity analysis of parameters are made to validate ...

  4. Atomic Stretch: Optimally bounded real-time stretching and beyond

    DEFF Research Database (Denmark)

    Jensen, Rasmus Ramsbøl; Nielsen, Jannik Boll

    2016-01-01

    Atomic Stretch is a plugin for your preferred Adobe video editing tool, allowing real-time smooth and optimally bounded retarget-ting from and to any aspect ratio. The plugin allows preserving of high interest pixels through a protected region, attention redirection through color-modification, co......Atomic Stretch is a plugin for your preferred Adobe video editing tool, allowing real-time smooth and optimally bounded retarget-ting from and to any aspect ratio. The plugin allows preserving of high interest pixels through a protected region, attention redirection through color...

  5. A PROCEDURE FOR DETERMINING OPTIMAL FACILITY LOCATION AND SUB-OPTIMAL POSITIONS

    Directory of Open Access Journals (Sweden)

    P.K. Dan

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: This research presents a methodology for determining the optimal location of a new facility, having physical flow interaction of various degrees with other existing facilities in the presence of barriers impeding the shortest flow-path as well as the sub-optimal iso-cost positions. It also determines sub-optimal iso-cost positions with additional cost or penalty for not being able to site it at the computed optimal point. The proposed methodology considers all types of quadrilateral barrier or forbidden region configurations to generalize and by-pass such impenetrable obstacles, and adopts a scheme of searching through the vertices of the quadrilaterals to determine the alternative shortest flow-path. This procedure of obstacle avoidance is novel. Software has been developed to facilitate computations for the search algorithm to determine the optimal and iso-cost co-ordinates. The test results are presented.

    AFRIKAANSE OPSOMMING: Die navorsing behandel ‘n procedure vir die bepaling van optimum stigtingsposisie vir ‘n onderneming met vloei vanaf ander bestaande fasiliteite in die teenwoordigheid van ‘n verskeidenheid van randvoorwaardes. Die prodedure lewer as resultaat suboptimale isokoste-stigtingsplekke met bekendmaking van die koste wat onstaan a.g.v. afwyking van die randvoorwaardlose optimum oplossingskoste, die prosedure maak gebruik van ‘n vindingryke soekmetode wat toegepas word op niersydige meerkundige voorstellings vir die bepaling van korste roetes wat versperring omseil. Die prosedure word onderskei deur programmatuur. Toetsresultate word voorgehou.

  6. Optimal critic learning for robot control in time-varying environments.

    Science.gov (United States)

    Wang, Chen; Li, Yanan; Ge, Shuzhi Sam; Lee, Tong Heng

    2015-10-01

    In this paper, optimal critic learning is developed for robot control in a time-varying environment. The unknown environment is described as a linear system with time-varying parameters, and impedance control is employed for the interaction control. Desired impedance parameters are obtained in the sense of an optimal realization of the composite of trajectory tracking and force regulation. Q -function-based critic learning is developed to determine the optimal impedance parameters without the knowledge of the system dynamics. The simulation results are presented and compared with existing methods, and the efficacy of the proposed method is verified.

  7. OPTIMIZING CONDITIONS FOR SPECTROPHOTOMETRIC DETERMINATION OF TOTAL POLYPHENOLS IN WINES USING FOLIN-CIOCALTEU REAGENT

    Directory of Open Access Journals (Sweden)

    Daniel Bajčan

    2013-02-01

    Full Text Available Wine is a complex beverage that obtains its properties mainly due to synergistic effect of alcohol, organic acids, arbohydrates, as well as the phenolic and aromatic substances. At present days, we can observe an increased interest in the study of polyphenols in wines that have antioxidant, antimicrobial, anti-inflammatory, anti-cancer and many other beneficial effects. Moderate and regular consumption of the red wine especially, with a high content of phenolic compounds, has a beneficial effect on human health. The aim of this work was to optimize conditions for spectrophotometric determination of total polyphenols in winwas to optimize conditions for spectrophotometric determination of total polyphenols in winwas to optimize conditions for spectrophotometric determination of total polyphenols in winwas to optimize conditions for pectrophotometric determination of total polyphenols in wine using Folin-Ciocaulteu reagent. Based on several studies, in order to minimize chemical use and optimize analysis time, we have proposed a method for the determination of total polyphenols using 0.25 ml Folin-Ciocaulteu reagent, 3 ml of 20% Na2CO3 solution and time of coloring complex 1.5 hour. We f

  8. Setting the optimal type of equipment to be adopted and the optimal time to replace it

    OpenAIRE

    Albici, Mihaela

    2009-01-01

    The mathematical models of equipment’s wear and tear, and replacement theory aim at deciding on the purchase selection of a certain equipment type, the optimal exploitation time of the equipment, the time and ways to replace or repair it, or to ensure its spare parts, the equipment’s performance in the technical progress context, the opportunities to modernize it etc.

  9. The optimal time of discontinuing methimazole before radioiodine therapy

    International Nuclear Information System (INIS)

    Moosavi, Z.; Zakavi, R.

    2001-01-01

    Hyperthyroidism is a common disease and one of the best methods for its treatment is radioiodine therapy with Treatment with antithyroid drugs brings patients to euthyroidism before radioiodine therapy. Antithyroid drugs should be discontinued before radioiodine therapy to increase thyroid uptake. The purpose of this study was to determine the optimal time of methimazole discontinuation. One hundred eighty four patients, who were referred for radioiodine therapy were classified in 3 groups according to the duration of methimazole discontinuation before thyroid uptake (RAIU) measurement. Group 1,2 and 3 were patients who discontinued methimazole (48-72 h rs), (72-120 h rs) and more than 120 h rs before RAIU measurement, respectively. Mean thyroid uptake in group 1, 2 and 3 was (64±151.1%), (60.1±14.1%) and (59.3±12.8), respectively. No significant difference was noted in thyroid uptake between these groups (F= 1.83, P<0.16). This study shows that 48-72 h rs of methimazole discontinuation before radioiodine therapy is enough and longer term abstention is not associated with higher uptake

  10. An Indirect Simulation-Optimization Model for Determining Optimal TMDL Allocation under Uncertainty

    Directory of Open Access Journals (Sweden)

    Feng Zhou

    2015-11-01

    Full Text Available An indirect simulation-optimization model framework with enhanced computational efficiency and risk-based decision-making capability was developed to determine optimal total maximum daily load (TMDL allocation under uncertainty. To convert the traditional direct simulation-optimization model into our indirect equivalent model framework, we proposed a two-step strategy: (1 application of interval regression equations derived by a Bayesian recursive regression tree (BRRT v2 algorithm, which approximates the original hydrodynamic and water-quality simulation models and accurately quantifies the inherent nonlinear relationship between nutrient load reductions and the credible interval of algal biomass with a given confidence interval; and (2 incorporation of the calibrated interval regression equations into an uncertain optimization framework, which is further converted to our indirect equivalent framework by the enhanced-interval linear programming (EILP method and provides approximate-optimal solutions at various risk levels. The proposed strategy was applied to the Swift Creek Reservoir’s nutrient TMDL allocation (Chesterfield County, VA to identify the minimum nutrient load allocations required from eight sub-watersheds to ensure compliance with user-specified chlorophyll criteria. Our results indicated that the BRRT-EILP model could identify critical sub-watersheds faster than the traditional one and requires lower reduction of nutrient loadings compared to traditional stochastic simulation and trial-and-error (TAE approaches. This suggests that our proposed framework performs better in optimal TMDL development compared to the traditional simulation-optimization models and provides extreme and non-extreme tradeoff analysis under uncertainty for risk-based decision making.

  11. Fast reactor parameter optimization taking into account changes in fuel charge type during reactor operation time

    International Nuclear Information System (INIS)

    Afrin, B.A.; Rechnov, A.V.; Usynin, G.B.

    1987-01-01

    The formulation and solution of optimization problem for parameters determining the layout of the central part of sodium cooled power reactor taking into account possible changes in fuel charge type during reactor operation time are performed. The losses under change of fuel composition type for two reactor modifications providing for minimum doubling time for oxide and carbide fuels respectively, are estimated

  12. Using real time traveler demand data to optimize commuter rail feeder systems.

    Science.gov (United States)

    2012-08-01

    "This report focuses on real time optimization of the Commuter Rail Circulator Route Network Design Problem (CRCNDP). The route configuration of the circulator system where to stop and the route among the stops is determined on a real-time ba...

  13. Optimization of extended propulsion time nuclear-electric propulsion trajectories

    Science.gov (United States)

    Sauer, C. G., Jr.

    1981-01-01

    This paper presents the methodology used in optimizing extended propulsion time NEP missions considering realistic thruster lifetime constraints. These missions consist of a powered spiral escape from a 700-km circular orbit at the earth, followed by a powered heliocentric transfer with an optimized coast phase, and terminating in a spiral capture phase at the target planet. This analysis is most applicable to those missions with very high energy requirements such as outer planet orbiter missions or sample return missions where the total propulsion time could greatly exceed the expected lifetime of an individual thruster. This methodology has been applied to the investigation of NEP missions to the outer planets where examples are presented of both constrained and optimized trajectories.

  14. Real Time Optimal Control of Supercapacitor Operation for Frequency Response

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yusheng; Panwar, Mayank; Mohanpurkar, Manish; Hovsapian, Rob

    2016-07-01

    Supercapacitors are gaining wider applications in power systems due to fast dynamic response. Utilizing supercapacitors by means of power electronics interfaces for power compensation is a proven effective technique. For applications such as requency restoration if the cost of supercapacitors maintenance as well as the energy loss on the power electronics interfaces are addressed. It is infeasible to use traditional optimization control methods to mitigate the impacts of frequent cycling. This paper proposes a Front End Controller (FEC) using Generalized Predictive Control featuring real time receding optimization. The optimization constraints are based on cost and thermal management to enhance to the utilization efficiency of supercapacitors. A rigorous mathematical derivation is conducted and test results acquired from Digital Real Time Simulator are provided to demonstrate effectiveness.

  15. Real-Time Determination of Solar Cell Parameters

    Science.gov (United States)

    Hassan Ali, Mohamed; Rabhi, Abdelhamid; Haddad, Sofiane; El Hajjaji, Ahmed

    2017-11-01

    The extraction of solar cell parameters is a difficult task but is an important step in the assessment procedure of solar cells and panels. This work presents numerical methods for determining these parameters and compares their performances under different solar irradiances when they are implemented in an equivalent electrical circuit model with one or two diodes. To obtain a fast convergence rate in real-time applications, the fractional-order Darwinian particle swarm optimization (FODPSO) method is used through experimental data collected from a platform of photovoltaic (PV) energy installed near the modeling, information and systems laboratory at Amiens, France. The results showed that the one-diode model is less representative than the two-diode model. Furthermore, it is envisaged that the proposed FODPSO-based extraction method is more effective in modeling with two diodes. This will allow real-time determination of solar cells parameters and consequently will help to select the most suitable PV model.

  16. Determinants of Optimal Adherence to Antiretroviral Therapy among ...

    African Journals Online (AJOL)

    SITWALA COMPUTERS

    medication side effects and adolescence were associated with non-adherence (p ... especially the social determinants of health surrounding ... irrespective of their CD4 cell count. ..... reported were cell phone alarm, radio news hour time, or a.

  17. Perturbing engine performance measurements to determine optimal engine control settings

    Science.gov (United States)

    Jiang, Li; Lee, Donghoon; Yilmaz, Hakan; Stefanopoulou, Anna

    2014-12-30

    Methods and systems for optimizing a performance of a vehicle engine are provided. The method includes determining an initial value for a first engine control parameter based on one or more detected operating conditions of the vehicle engine, determining a value of an engine performance variable, and artificially perturbing the determined value of the engine performance variable. The initial value for the first engine control parameter is then adjusted based on the perturbed engine performance variable causing the engine performance variable to approach a target engine performance variable. Operation of the vehicle engine is controlled based on the adjusted initial value for the first engine control parameter. These acts are repeated until the engine performance variable approaches the target engine performance variable.

  18. Determining Optimal Replacement Policy with an Availability Constraint via Genetic Algorithms

    OpenAIRE

    Zong, Shengliang; Chai, Guorong; Su, Yana

    2017-01-01

    We develop a model and a genetic algorithm for determining an optimal replacement policy for power equipment subject to Poisson shocks. If the time interval of two consecutive shocks is less than a threshold value, the failed equipment can be repaired. We assume that the operating time after repair is stochastically nonincreasing and the repair time is exponentially distributed with a geometric increasing mean. Our objective is to minimize the expected average cost under an availability requi...

  19. Human error considerations and annunciator effects in determining optimal test intervals for periodically inspected standby systems

    International Nuclear Information System (INIS)

    McWilliams, T.P.; Martz, H.F.

    1981-01-01

    This paper incorporates the effects of four types of human error in a model for determining the optimal time between periodic inspections which maximizes the steady state availability for standby safety systems. Such safety systems are characteristic of nuclear power plant operations. The system is modeled by means of an infinite state-space Markov chain. Purpose of the paper is to demonstrate techniques for computing steady-state availability A and the optimal periodic inspection interval tau* for the system. The model can be used to investigate the effects of human error probabilities on optimal availability, study the benefits of annunciating the standby-system, and to determine optimal inspection intervals. Several examples which are representative of nuclear power plant applications are presented

  20. Real-time trajectory optimization on parallel processors

    Science.gov (United States)

    Psiaki, Mark L.

    1993-01-01

    A parallel algorithm has been developed for rapidly solving trajectory optimization problems. The goal of the work has been to develop an algorithm that is suitable to do real-time, on-line optimal guidance through repeated solution of a trajectory optimization problem. The algorithm has been developed on an INTEL iPSC/860 message passing parallel processor. It uses a zero-order-hold discretization of a continuous-time problem and solves the resulting nonlinear programming problem using a custom-designed augmented Lagrangian nonlinear programming algorithm. The algorithm achieves parallelism of function, derivative, and search direction calculations through the principle of domain decomposition applied along the time axis. It has been encoded and tested on 3 example problems, the Goddard problem, the acceleration-limited, planar minimum-time to the origin problem, and a National Aerospace Plane minimum-fuel ascent guidance problem. Execution times as fast as 118 sec of wall clock time have been achieved for a 128-stage Goddard problem solved on 32 processors. A 32-stage minimum-time problem has been solved in 151 sec on 32 processors. A 32-stage National Aerospace Plane problem required 2 hours when solved on 32 processors. A speed-up factor of 7.2 has been achieved by using 32-nodes instead of 1-node to solve a 64-stage Goddard problem.

  1. An Optimization Method of Time Window Based on Travel Time and Reliability

    Directory of Open Access Journals (Sweden)

    Fengjie Fu

    2015-01-01

    Full Text Available The dynamic change of urban road travel time was analyzed using video image detector data, and it showed cyclic variation, so the signal cycle length at the upstream intersection was conducted as the basic unit of time window; there was some evidence of bimodality in the actual travel time distributions; therefore, the fitting parameters of the travel time bimodal distribution were estimated using the EM algorithm. Then the weighted average value of the two means was indicated as the travel time estimation value, and the Modified Buffer Time Index (MBIT was expressed as travel time variability; based on the characteristics of travel time change and MBIT along with different time windows, the time window was optimized dynamically for minimum MBIT, requiring that the travel time change be lower than the threshold value and traffic incidents can be detected real time; finally, travel times on Shandong Road in Qingdao were estimated every 10 s, 120 s, optimal time windows, and 480 s and the comparisons demonstrated that travel time estimation in optimal time windows can exactly and steadily reflect the real-time traffic. It verifies the effectiveness of the optimization method.

  2. Online gaming for learning optimal team strategies in real time

    Science.gov (United States)

    Hudas, Gregory; Lewis, F. L.; Vamvoudakis, K. G.

    2010-04-01

    This paper first presents an overall view for dynamical decision-making in teams, both cooperative and competitive. Strategies for team decision problems, including optimal control, zero-sum 2-player games (H-infinity control) and so on are normally solved for off-line by solving associated matrix equations such as the Riccati equation. However, using that approach, players cannot change their objectives online in real time without calling for a completely new off-line solution for the new strategies. Therefore, in this paper we give a method for learning optimal team strategies online in real time as team dynamical play unfolds. In the linear quadratic regulator case, for instance, the method learns the Riccati equation solution online without ever solving the Riccati equation. This allows for truly dynamical team decisions where objective functions can change in real time and the system dynamics can be time-varying.

  3. Resource-Optimal Scheduling Using Priced Timed Automata

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Rasmussen, Jacob Illum; Subramani, K.

    2004-01-01

    In this paper, we show how the simple structure of the linear programs encountered during symbolic minimum-cost reachability analysis of priced timed automata can be exploited in order to substantially improve the performance of the current algorithm. The idea is rooted in duality of linear......-80 percent performance gain. As a main application area, we show how to solve energy-optimal task graph scheduling problems using the framework of priced timed automata....

  4. Application of artificial neural network to predict the optimal start time for heating system in building

    International Nuclear Information System (INIS)

    Yang, In-Ho; Yeo, Myoung-Souk; Kim, Kwang-Woo

    2003-01-01

    The artificial neural network (ANN) approach is a generic technique for mapping non-linear relationships between inputs and outputs without knowing the details of these relationships. This paper presents an application of the ANN in a building control system. The objective of this study is to develop an optimized ANN model to determine the optimal start time for a heating system in a building. For this, programs for predicting the room air temperature and the learning of the ANN model based on back propagation learning were developed, and learning data for various building conditions were collected through program simulation for predicting the room air temperature using systems of experimental design. Then, the optimized ANN model was presented through learning of the ANN, and its performance to determine the optimal start time was evaluated

  5. Optimal contant time injection policy for enhanced oil recovery and characterization of optimal viscous profiles

    Science.gov (United States)

    Daripa, Prabir

    2011-11-01

    We numerically investigate the optimal viscous profile in constant time injection policy of enhanced oil recovery. In particular, we investigate the effect of a combination of interfacial and layer instabilities in three-layer porous media flow on the overall growth of instabilities and thereby characterize the optimal viscous profile. Results based on monotonic and non-monotonic viscous profiles will be presented. Time permitting. we will also present results on multi-layer porous media flows for Newtonian and non-Newtonian fluids and compare the results. The support of Qatar National Fund under a QNRF Grant is acknowledged.

  6. Optimal moving grids for time-dependent partial differential equations

    Science.gov (United States)

    Wathen, A. J.

    1992-01-01

    Various adaptive moving grid techniques for the numerical solution of time-dependent partial differential equations were proposed. The precise criterion for grid motion varies, but most techniques will attempt to give grids on which the solution of the partial differential equation can be well represented. Moving grids are investigated on which the solutions of the linear heat conduction and viscous Burgers' equation in one space dimension are optimally approximated. Precisely, the results of numerical calculations of optimal moving grids for piecewise linear finite element approximation of PDE solutions in the least-squares norm are reported.

  7. Optimal redundant systems for works with random processing time

    International Nuclear Information System (INIS)

    Chen, M.; Nakagawa, T.

    2013-01-01

    This paper studies the optimal redundant policies for a manufacturing system processing jobs with random working times. The redundant units of the parallel systems and standby systems are subject to stochastic failures during the continuous production process. First, a job consisting of only one work is considered for both redundant systems and the expected cost functions are obtained. Next, each redundant system with a random number of units is assumed for a single work. The expected cost functions and the optimal expected numbers of units are derived for redundant systems. Subsequently, the production processes of N tandem works are introduced for parallel and standby systems, and the expected cost functions are also summarized. Finally, the number of works is estimated by a Poisson distribution for the parallel and standby systems. Numerical examples are given to demonstrate the optimization problems of redundant systems

  8. Real-Time Demand Side Management Algorithm Using Stochastic Optimization

    Directory of Open Access Journals (Sweden)

    Moses Amoasi Acquah

    2018-05-01

    Full Text Available A demand side management technique is deployed along with battery energy-storage systems (BESS to lower the electricity cost by mitigating the peak load of a building. Most of the existing methods rely on manual operation of the BESS, or even an elaborate building energy-management system resorting to a deterministic method that is susceptible to unforeseen growth in demand. In this study, we propose a real-time optimal operating strategy for BESS based on density demand forecast and stochastic optimization. This method takes into consideration uncertainties in demand when accounting for an optimal BESS schedule, making it robust compared to the deterministic case. The proposed method is verified and tested against existing algorithms. Data obtained from a real site in South Korea is used for verification and testing. The results show that the proposed method is effective, even for the cases where the forecasted demand deviates from the observed demand.

  9. Optimal Real-time Dispatch for Integrated Energy Systems

    DEFF Research Database (Denmark)

    Anvari-Moghaddam, Amjad; Guerrero, Josep M.; Rahimi-Kian, Ashkan

    2016-01-01

    With the emerging of small-scale integrated energy systems (IESs), there are significant potentials to increase the functionality of a typical demand-side management (DSM) strategy and typical implementation of building-level distributed energy resources (DERs). By integrating DSM and DERs...... into a cohesive, networked package that fully utilizes smart energy-efficient end-use devices, advanced building control/automation systems, and integrated communications architectures, it is possible to efficiently manage energy and comfort at the end-use location. In this paper, an ontology-driven multi......-agent control system with intelligent optimizers is proposed for optimal real-time dispatch of an integrated building and microgrid system considering coordinated demand response (DR) and DERs management. The optimal dispatch problem is formulated as a mixed integer nonlinear programing problem (MINLP...

  10. Dynamic ADMM for Real-time Optimal Power Flow: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Dall-Anese, Emiliano [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-02-23

    This paper considers distribution networks featuring distributed energy resources (DERs), and develops a dynamic optimization method to maximize given operational objectives in real time while adhering to relevant network constraints. The design of the dynamic algorithm is based on suitable linearizations of the AC power flow equations, and it leverages the so-called alternating direction method of multipliers (ADMM). The steps of the ADMM, however, are suitably modified to accommodate appropriate measurements from the distribution network and the DERs. With the aid of these measurements, the resultant algorithm can enforce given operational constraints in spite of inaccuracies in the representation of the AC power flows, and it avoids ubiquitous metering to gather the state of non-controllable resources. Optimality and convergence of the propose algorithm are established in terms of tracking of the solution of a convex surrogate of the AC optimal power flow problem.

  11. Determination of optimal conditions of oxytetracyclin production from streptomyces rimosus

    International Nuclear Information System (INIS)

    Zouaghi, Atef

    2007-01-01

    Streptomyces rimosus is an oxytetracycline (OTC) antibiotic producing bacteria that exhibited activities against gram positive and negative bacteria. OTC is used widely not only in medicine but also in production industry. The antibiotic production of streptomyces covers a very wide range of condition. However, antibiotic producers are particularly fastidious cultivated by proper selection of media such as carbon source. In present study we have optimised conditions of OTC production (Composition of production media, p H, shaking and temperature). The results have been shown that bran barley is the optimal media for OTC production at 28C pH5.8 at 150rpm for 5 days. For antibiotic determination, OTC was extracted with different organic solvent. Thin-layer chromatography system was used for separation and identification of OTC antibiotic. High performance liquid chromatographic (HPLC) method with ultraviolet detection for the analysis of OTC is applied to the determination of OTC purification. (Author). 24 refs

  12. Determination of Pareto frontier in multi-objective maintenance optimization

    International Nuclear Information System (INIS)

    Certa, Antonella; Galante, Giacomo; Lupo, Toni; Passannanti, Gianfranco

    2011-01-01

    The objective of a maintenance policy generally is the global maintenance cost minimization that involves not only the direct costs for both the maintenance actions and the spare parts, but also those ones due to the system stop for preventive maintenance and the downtime for failure. For some operating systems, the failure event can be dangerous so that they are asked to operate assuring a very high reliability level between two consecutive fixed stops. The present paper attempts to individuate the set of elements on which performing maintenance actions so that the system can assure the required reliability level until the next fixed stop for maintenance, minimizing both the global maintenance cost and the total maintenance time. In order to solve the previous constrained multi-objective optimization problem, an effective approach is proposed to obtain the best solutions (that is the Pareto optimal frontier) among which the decision maker will choose the more suitable one. As well known, describing the whole Pareto optimal frontier generally is a troublesome task. The paper proposes an algorithm able to rapidly overcome this problem and its effectiveness is shown by an application to a case study regarding a complex series-parallel system.

  13. Time-Optimal Real-Time Test Case Generation using UPPAAL

    DEFF Research Database (Denmark)

    Hessel, Anders; Larsen, Kim Guldstrand; Nielsen, Brian

    2004-01-01

    Testing is the primary software validation technique used by industry today, but remains ad hoc, error prone, and very expensive. A promising improvement is to automatically generate test cases from formal models of the system under test. We demonstrate how to automatically generate real...... test purposes or generated automatically from various coverage criteria of the model.......-time conformance test cases from timed automata specifications. Specifically we demonstrate how to fficiently generate real-time test cases with optimal execution time i.e test cases that are the fastest possible to execute. Our technique allows time optimal test cases to be generated using manually formulated...

  14. Optimizing capital and time expenditures for drilling service operations

    Energy Technology Data Exchange (ETDEWEB)

    Zazovskiy, F Ya; Soltysyak, T I

    1980-01-01

    The operational efficiency of drilling services operations management are examined. The structure of time expenditure is analyzed for repair operations according to equipment type employed by the Ivano-Frankovsk Drilling Management under the Ukrneft' enterprise during 1977. The results of this analysis are weighed against a series of service operations carried out at industrial enterprises and connected with technical disruptions. Some of the cases examined include service competion operations outside of the industrial units when technical processes are disrupted only for the change of equipment which has outlived its usefulness and is no longer in series production. First of all, time expended for repair work can be reduced to zero during the drilling of shallow wells which do not require extensive drilling time. The actual savings, both in time and money, as far as repair work is concerned, hinges on the actual time factor for total oil depetion. An equation is provided for optimal time expenditure necessary for repair work and equipment replacement. An actual example is given from the Dolinsk UBR (Drillin Management) under the Ukrneft' enterprise where time spent on actual service operations has appeared to be less than the optimal figure cited in the above material. This is possible because of increased capital expenditures.

  15. DETERMINATION OF BRAKING OPTIMAL MODE OF CONTROLLED CUT OF DESIGN GROUP

    Directory of Open Access Journals (Sweden)

    A. S. Dorosh

    2015-06-01

    Full Text Available Purpose. The application of automation systems of breaking up process on the gravity hump is the efficiency improvement of their operation, absolute provision of trains breaking up safety demands, as well as improvement of hump staff working conditions. One of the main tasks of the indicated systems is the assurance of cuts reliable separation at all elements of their rolling route to the classification track. This task is a sophisticated optimization problem and has not received a final decision. Therefore, the task of determining the cuts braking mode is quite relevant. The purpose of this research is to find the optimal braking mode of control cut of design group. Methodology. In order to achieve the purpose is offered to use the direct search methods in the work, namely the Box complex method. This method does not require smoothness of the objective function, takes into account its limitations and does not require calculation of the function derivatives, and uses only its value. Findings. Using the Box method was developed iterative procedure for determining the control cut optimal braking mode of design group. The procedure maximizes the smallest controlled time interval in the group. To evaluate the effectiveness of designed procedure the series of simulation experiments of determining the control cut braking mode of design group was performed. The results confirmed the efficiency of the developed optimization procedure. Originality. The author formalized the task of optimizing control cut braking mode of design group, taking into account the cuts separation of design group at all elements (switches, retarders during cuts rolling to the classification track. The problem of determining the optimal control cut braking mode of design group was solved. The developed braking mode ensures cuts reliable separation of the group not only at the switches but at the retarders of brake position. Practical value. The developed procedure can be

  16. Developing an optimal valve closing rule curve for real-time pressure control in pipes

    Energy Technology Data Exchange (ETDEWEB)

    Bazarganlari, Mohammad Reza; Afshar, Hossein [Islamic Azad University, Tehran (Iran, Islamic Republic of); Kerachian, Reza [University of Tehran, Tehran (Iran, Islamic Republic of); Bashiazghadi, Seyyed Nasser [Iran University of Science and Technology, Tehran (Iran, Islamic Republic of)

    2013-01-15

    Sudden valve closure in pipeline systems can cause high pressures that may lead to serious damages. Using an optimal valve closing rule can play an important role in managing extreme pressures in sudden valve closure. In this paper, an optimal closing rule curve is developed using a multi-objective optimization model and Bayesian networks (BNs) for controlling water pressure in valve closure instead of traditional step functions or single linear functions. The method of characteristics is used to simulate transient flow caused by valve closure. Non-dominated sorting genetic algorithms-II is also used to develop a Pareto front among three objectives related to maximum and minimum water pressures, and the amount of water passes through the valve during the valve-closing process. Simulation and optimization processes are usually time-consuming, thus results of the optimization model are used for training the BN. The trained BN is capable of determining optimal real-time closing rules without running costly simulation and optimization models. To demonstrate its efficiency, the proposed methodology is applied to a reservoir-pipe-valve system and the optimal closing rule curve is calculated for the valve. The results of the linear and BN-based valve closure rules show that the latter can significantly reduce the range of variations in water hammer pressures.

  17. Overconfidence, Managerial Optimism, and the Determinants of Capital Structure

    Directory of Open Access Journals (Sweden)

    Alexandre di Miceli da Silveira

    2008-12-01

    Full Text Available This research examines the determinants of the capital structure of firms introducing a behavioral perspective that has received little attention in corporate finance literature. The following central hypothesis emerges from a set of recently developed theories: firms managed by optimistic and/or overconfident people will choose more levered financing structures than others, ceteris paribus. We propose different proxies for optimism/overconfidence, based on the manager’s status as an entrepreneur or non-entrepreneur, an idea that is supported by theories and solid empirical evidence, as well as on the pattern of ownership of the firm’s shares by its manager. The study also includes potential determinants of capital structure used in earlier research. We use a sample of Brazilian firms listed in the Sao Paulo Stock Exchange (Bovespa in the years 1998 to 2003. The empirical analysis suggests that the proxies for the referred cognitive biases are important determinants of capital structure. We also found as relevant explanatory variables: profitability, size, dividend payment and tangibility, as well as some indicators that capture the firms’ corporate governance standards. These results suggest that behavioral approaches based on human psychology research can offer relevant contributions to the understanding of corporate decision making.

  18. Determining of the Optimal Device Lifetime using Mathematical Renewal Models

    Directory of Open Access Journals (Sweden)

    Knežo Dušan

    2016-05-01

    Full Text Available Paper deals with the operations and equipment of the machine in the process of organizing production. During operation machines require maintenance and repairs, while in case of failure or machine wears it is necessary to replace them with new ones. For the process of replacement of old machines with new ones the term renewal is used. Qualitative aspects of the renewal process observe renewal theory, which is mainly based on the theory of probability and mathematical statistics. Devices lifetimes are closely related to the renewal of the devices. Presented article is focused on mathematical deduction of mathematical renewal models and determining optimal lifetime of the devices from the aspect of expenditures on renewal process.

  19. Chaos Time Series Prediction Based on Membrane Optimization Algorithms

    Directory of Open Access Journals (Sweden)

    Meng Li

    2015-01-01

    Full Text Available This paper puts forward a prediction model based on membrane computing optimization algorithm for chaos time series; the model optimizes simultaneously the parameters of phase space reconstruction (τ,m and least squares support vector machine (LS-SVM (γ,σ by using membrane computing optimization algorithm. It is an important basis for spectrum management to predict accurately the change trend of parameters in the electromagnetic environment, which can help decision makers to adopt an optimal action. Then, the model presented in this paper is used to forecast band occupancy rate of frequency modulation (FM broadcasting band and interphone band. To show the applicability and superiority of the proposed model, this paper will compare the forecast model presented in it with conventional similar models. The experimental results show that whether single-step prediction or multistep prediction, the proposed model performs best based on three error measures, namely, normalized mean square error (NMSE, root mean square error (RMSE, and mean absolute percentage error (MAPE.

  20. Optimal model-free prediction from multivariate time series

    Science.gov (United States)

    Runge, Jakob; Donner, Reik V.; Kurths, Jürgen

    2015-05-01

    Forecasting a time series from multivariate predictors constitutes a challenging problem, especially using model-free approaches. Most techniques, such as nearest-neighbor prediction, quickly suffer from the curse of dimensionality and overfitting for more than a few predictors which has limited their application mostly to the univariate case. Therefore, selection strategies are needed that harness the available information as efficiently as possible. Since often the right combination of predictors matters, ideally all subsets of possible predictors should be tested for their predictive power, but the exponentially growing number of combinations makes such an approach computationally prohibitive. Here a prediction scheme that overcomes this strong limitation is introduced utilizing a causal preselection step which drastically reduces the number of possible predictors to the most predictive set of causal drivers making a globally optimal search scheme tractable. The information-theoretic optimality is derived and practical selection criteria are discussed. As demonstrated for multivariate nonlinear stochastic delay processes, the optimal scheme can even be less computationally expensive than commonly used suboptimal schemes like forward selection. The method suggests a general framework to apply the optimal model-free approach to select variables and subsequently fit a model to further improve a prediction or learn statistical dependencies. The performance of this framework is illustrated on a climatological index of El Niño Southern Oscillation.

  1. On test and maintenance: Optimization of allowed outage time

    International Nuclear Information System (INIS)

    Mavko, B.; Cepin, M.T.

    2000-01-01

    Probabilistic Safety Assessment is widely becoming standard method for assessing, maintaining, assuring and improving the nuclear power plant safety. To achieve one of its many potential benefits, the optimization of allowed outage time specified in technical specifications is investigated. Proposed is the risk comparison approach for evaluation of allowed outage time. The risk of shutting the plant down due to failure of certain equipment is compared to the risk of continued plant operation with the specified equipment down. The core damage frequency serves as a risk measure. (author)

  2. Time-limited optimal dynamics beyond the Quantum Speed Limit

    DEFF Research Database (Denmark)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan

    2015-01-01

    The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed has to be paid with a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven......-off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian, and a classification...

  3. Simultaneous Optimization of Container Ship Sailing Speed and Container Routing with Transit Time Restrictions

    DEFF Research Database (Denmark)

    Karsten, Christian Vad; Røpke, Stefan; Pisinger, David

    We introduce a decision support tool for liner shipping companies to optimally determine the sailing speed and needed fleet for a global network. As a novelty we incorporate cargo routing decisions with tight transit time restrictions on each container such that we get a realistic picture...

  4. Optimization of Partitioned Architectures to Support Soft Real-Time Applications

    DEFF Research Database (Denmark)

    Tamas-Selicean, Domitian; Pop, Paul

    2014-01-01

    In this paper we propose a new Tabu Search-based design optimization strategy for mixed-criticality systems implementing hard and soft real-time applications on the same platform. Our proposed strategy determined an implementation such that all hard real-time applications are schedulable and the ......In this paper we propose a new Tabu Search-based design optimization strategy for mixed-criticality systems implementing hard and soft real-time applications on the same platform. Our proposed strategy determined an implementation such that all hard real-time applications are schedulable...... and the quality of service of the soft real-time tasks is maximized. We have evaluated our strategy using an aerospace case study....

  5. Model for determining and optimizing delivery performance in industrial systems

    Directory of Open Access Journals (Sweden)

    Fechete Flavia

    2017-01-01

    Full Text Available Performance means achieving organizational objectives regardless of their nature and variety, and even overcoming them. Improving performance is one of the major goals of any company. Achieving the global performance means not only obtaining the economic performance, it is a must to take into account other functions like: function of quality, delivery, costs and even the employees satisfaction. This paper aims to improve the delivery performance of an industrial system due to their very low results. The delivery performance took into account all categories of performance indicators, such as on time delivery, backlog efficiency or transport efficiency. The research was focused on optimizing the delivery performance of the industrial system, using linear programming. Modeling the delivery function using linear programming led to obtaining precise quantities to be produced and delivered each month by the industrial system in order to minimize their transport cost, satisfying their customers orders and to control their stock. The optimization led to a substantial improvement in all four performance indicators that concern deliveries.

  6. Time-optimal thermalization of single-mode Gaussian states

    Science.gov (United States)

    Carlini, Alberto; Mari, Andrea; Giovannetti, Vittorio

    2014-11-01

    We consider the problem of time-optimal control of a continuous bosonic quantum system subject to the action of a Markovian dissipation. In particular, we consider the case of a one-mode Gaussian quantum system prepared in an arbitrary initial state and which relaxes to the steady state due to the action of the dissipative channel. We assume that the unitary part of the dynamics is represented by Gaussian operations which preserve the Gaussian nature of the quantum state, i.e., arbitrary phase rotations, bounded squeezing, and unlimited displacements. In the ideal ansatz of unconstrained quantum control (i.e., when the unitary phase rotations, squeezing, and displacement of the mode can be performed instantaneously), we study how control can be optimized for speeding up the relaxation towards the fixed point of the dynamics and we analytically derive the optimal relaxation time. Our model has potential and interesting applications to the control of modes of electromagnetic radiation and of trapped levitated nanospheres.

  7. The Optimal Timing of Adoption of a Green Technology

    International Nuclear Information System (INIS)

    Cunha-e-Sa, M.A.; Reis, A.B.

    2007-01-01

    We study the optimal timing of adoption of a cleaner technology and its effects on the rate of growth of an economy in the context of an AK endogenous growth model. We show that the results depend upon the behavior of the marginal utility of environmental quality with respect to consumption. When it is increasing, we derive the capital level at the optimal timing of adoption. We show that this capital threshold is independent of the initial conditions on the stock of capital, implying that capital-poor countries tend to take longer to adopt. Also, country-specific characteristics, as the existence of high barriers to adoption, may lead to different capital thresholds for different countries. If the marginal utility of environmental quality decreases with consumption, a country should never delay adoption; the optimal policy is either to adopt immediately or, if adoption costs are t oo high , to never adopt. The policy implications of these results are discussed in the context of the international debate surrounding the environmental political agenda

  8. Cool down time optimization of the Stirling cooler

    Science.gov (United States)

    Xia, M.; Chen, X. P.; Y Li, H.; Gan, Z. H.

    2017-12-01

    The cooling power is one of the most important performances of a Stirling cooler. However, in some special fields, the cool down time is more important. It is a great challenge to improve the cool down time of the Stirling cooler. A new split Stirling linear cryogenic cooler SCI09H was designed in this study. A new structure of linear motor is used in the compressor, and the machine spring is used in the expander. In order to reduce the cool down time, the stainless-steel mesh of regenerator is optimized. The weight of the cooler is 1.1 kg, the cool down time to 80K is 2 minutes at 296K with a 250J thermal mass, the cooling power is 1.1W at 80K, and the input power is 50W.

  9. Time Optimized Algorithm for Web Document Presentation Adaptation

    DEFF Research Database (Denmark)

    Pan, Rong; Dolog, Peter

    2010-01-01

    Currently information on the web is accessed through different devices. Each device has its own properties such as resolution, size, and capabilities to display information in different format and so on. This calls for adaptation of information presentation for such platforms. This paper proposes...... content-optimized and time-optimized algorithms for information presentation adaptation for different devices based on its hierarchical model. The model is formalized in order to experiment with different algorithms.......Currently information on the web is accessed through different devices. Each device has its own properties such as resolution, size, and capabilities to display information in different format and so on. This calls for adaptation of information presentation for such platforms. This paper proposes...

  10. Optimal trading strategies—a time series approach

    Science.gov (United States)

    Bebbington, Peter A.; Kühn, Reimer

    2016-05-01

    Motivated by recent advances in the spectral theory of auto-covariance matrices, we are led to revisit a reformulation of Markowitz’ mean-variance portfolio optimization approach in the time domain. In its simplest incarnation it applies to a single traded asset and allows an optimal trading strategy to be found which—for a given return—is minimally exposed to market price fluctuations. The model is initially investigated for a range of synthetic price processes, taken to be either second order stationary, or to exhibit second order stationary increments. Attention is paid to consequences of estimating auto-covariance matrices from small finite samples, and auto-covariance matrix cleaning strategies to mitigate against these are investigated. Finally we apply our framework to real world data.

  11. Real-time aircraft continuous descent trajectory optimization with ATC time constraints using direct collocation methods.

    OpenAIRE

    Verhoeven, Ronald; Dalmau Codina, Ramon; Prats Menéndez, Xavier; de Gelder, Nico

    2014-01-01

    1 Abstract In this paper an initial implementation of a real - time aircraft trajectory optimization algorithm is presented . The aircraft trajectory for descent and approach is computed for minimum use of thrust and speed brake in support of a “green” continuous descent and approach flight operation, while complying with ATC time constraints for maintaining runway throughput and co...

  12. Optimal design and use of retry in fault tolerant real-time computer systems

    Science.gov (United States)

    Lee, Y. H.; Shin, K. G.

    1983-01-01

    A new method to determin an optimal retry policy and for use in retry of fault characterization is presented. An optimal retry policy for a given fault characteristic, which determines the maximum allowable retry durations to minimize the total task completion time was derived. The combined fault characterization and retry decision, in which the characteristics of fault are estimated simultaneously with the determination of the optimal retry policy were carried out. Two solution approaches were developed, one based on the point estimation and the other on the Bayes sequential decision. The maximum likelihood estimators are used for the first approach, and the backward induction for testing hypotheses in the second approach. Numerical examples in which all the durations associated with faults have monotone hazard functions, e.g., exponential, Weibull and gamma distributions are presented. These are standard distributions commonly used for modeling analysis and faults.

  13. A Monte Carlo simulation technique to determine the optimal portfolio

    Directory of Open Access Journals (Sweden)

    Hassan Ghodrati

    2014-03-01

    Full Text Available During the past few years, there have been several studies for portfolio management. One of the primary concerns on any stock market is to detect the risk associated with various assets. One of the recognized methods in order to measure, to forecast, and to manage the existing risk is associated with Value at Risk (VaR, which draws much attention by financial institutions in recent years. VaR is a method for recognizing and evaluating of risk, which uses the standard statistical techniques and the method has been used in other fields, increasingly. The present study has measured the value at risk of 26 companies from chemical industry in Tehran Stock Exchange over the period 2009-2011 using the simulation technique of Monte Carlo with 95% confidence level. The used variability in the present study has been the daily return resulted from the stock daily price change. Moreover, the weight of optimal investment has been determined using a hybrid model called Markowitz and Winker model in each determined stocks. The results showed that the maximum loss would not exceed from 1259432 Rials at 95% confidence level in future day.

  14. Real balance effects, timing, and equilibrium determination

    NARCIS (Netherlands)

    Stoltenberg, C.A.

    2012-01-01

    By assuming that money balances at the beginning instead of at the end of the period provide transaction services, standard results on nominal and real determinacy in monetary models are overturned. The key is that predetermined real money balances can be a state variable. Whereas the determination

  15. Determining the optimal number of Kanban in multi-products supply chain system

    Science.gov (United States)

    Widyadana, G. A.; Wee, H. M.; Chang, Jer-Yuan

    2010-02-01

    Kanban, a key element of just-in-time system, is a re-order card or signboard giving instruction or triggering the pull system to manufacture or supply a component based on actual usage of material. There are two types of Kanban: production Kanban and withdrawal Kanban. This study uses optimal and meta-heuristic methods to determine the Kanban quantity and withdrawal lot sizes in a supply chain system. Although the mix integer programming method gives an optimal solution, it is not time efficient. For this reason, the meta-heuristic methods are suggested. In this study, a genetic algorithm (GA) and a hybrid of genetic algorithm and simulated annealing (GASA) are used. The study compares the performance of GA and GASA with that of the optimal method using MIP. The given problems show that both GA and GASA result in a near optimal solution, and they outdo the optimal method in term of run time. In addition, the GASA heuristic method gives a better performance than the GA heuristic method.

  16. Determining the optimal monetary policy instrument for Nigeria

    OpenAIRE

    Udom, Solomon I.; Yaaba, Baba N.

    2015-01-01

    It is considered inapt for central banks to adjust reserve money (quantity of money) and interest rate (price of money) at the same time. Thus, necessitates the need for a choice instrument. Enough evidence abounds in microeconomic theory on the undesirability of manipulating both price and quantity simultaneously in a free market structure. The market, in line with the consensus among economists, either controls the price and allows quantity to be determined by market forces, or influence qu...

  17. Optimal Time Allocation in Backscatter Assisted Wireless Powered Communication Networks

    Science.gov (United States)

    Lyu, Bin; Yang, Zhen; Gui, Guan; Sari, Hikmet

    2017-01-01

    This paper proposes a wireless powered communication network (WPCN) assisted by backscatter communication (BackCom). This model consists of a power station, an information receiver and multiple users that can work in either BackCom mode or harvest-then-transmit (HTT) mode. The time block is mainly divided into two parts corresponding to the data backscattering and transmission periods, respectively. The users first backscatter data to the information receiver in time division multiple access (TDMA) during the data backscattering period. When one user works in the BackCom mode, the other users harvest energy from the power station. During the data transmission period, two schemes, i.e., non-orthogonal multiple access (NOMA) and TDMA, are considered. To maximize the system throughput, the optimal time allocation policies are obtained. Simulation results demonstrate the superiority of the proposed model. PMID:28587171

  18. Time Optimal Synchronization Procedure and Associated Feedback Loops

    CERN Document Server

    Angoletta, Maria Elena; CERN. Geneva. ATS Department

    2016-01-01

    A procedure to increase the speed of currently used synchronization loops in a synchrotron by an order of magnitude is presented. Beams dynamics constraint imposes an upper limit on excursions in stable phase angle, and the procedure presented exploits this limit to arrive in the synchronized state from an arbitrary initial state in the fastest possible way. Detailed corrector design for beam phase loop, differential frequency loop and final synchronization loop is also presented. Finally, an overview of the synchronization methods currently deployed in some other CERN’s machines is provided, together with a brief comparison with the newly proposed time-optimal algorithm.

  19. Optimizing the radioimmunologic determination methods for cortisol and calcitonin

    International Nuclear Information System (INIS)

    Stalla, G.

    1981-01-01

    In order to build up a specific 125-iodine cortisol radioimmunoassay (RIA) pure cortisol-3(0-carbodxymethyl) oxim was synthesized for teh production of antigens and tracers. The cortisol was coupled with tyrosin methylester and then labelled with 125-iodine. For the antigen production the cortisol derivate was coupled with the same method to thyreoglobulin. The major part of the antisera, which were obtained like this, presented high titres. Apart from a high specificity for cortisol a high affinity was found in the acid pH-area and quantified with a particularly developed computer program. An extractive step in the cortisol RIA could be prevented by efforts. The assay was carried out with an optimized double antibody principle: The reaction time between the first and the second antiserum was considerably accelerated by the administration of polyaethylenglycol. The assay can be carried out automatically by applying a modular analysis system, which operates fast and provides a large capacity. The required quality and accuracy controls were done. The comparison of this assay with other cortisol-RIA showed good correlation. The RIA for human clacitonin was improved. For separating bound and freely mobile hormones the optimized double-antibody technique was applied. The antiserum was examined with respect to its affinity to calcitonin. For the 'zero serum' production the Florisil extraction method was used. The criteria of the quality and accuracy controls were complied. Significantly increased calcitonin concentrations were found in a patient group with medullar thyroid carcinoma and in two patients with an additional phaechromocytoma. (orig./MG) [de

  20. Lyapunov matrices approach to the parametric optimization of time-delay systems

    Directory of Open Access Journals (Sweden)

    Duda Józef

    2015-09-01

    Full Text Available In the paper a Lyapunov matrices approach to the parametric optimization problem of time-delay systems with a P-controller is presented. The value of integral quadratic performance index of quality is equal to the value of Lyapunov functional for the initial function of the time-delay system. The Lyapunov functional is determined by means of the Lyapunov matrix

  1. Optimization of Allowed Outage Time and Surveillance Test Intervals

    Energy Technology Data Exchange (ETDEWEB)

    Al-Dheeb, Mujahed; Kang, Sunkoo; Kim, Jonghyun [KEPCO international nuclear graduate school, Ulsan (Korea, Republic of)

    2015-10-15

    The primary purpose of surveillance testing is to assure that the components of standby safety systems will be operable when they are needed in an accident. By testing these components, failures can be detected that may have occurred since the last test or the time when the equipment was last known to be operational. The probability a system or system component performs a specified function or mission under given conditions at a prescribed time is called availability (A). Unavailability (U) as a risk measure is just the complementary probability to A(t). The increase of U means the risk is increased as well. D and T have an important impact on components, or systems, unavailability. The extension of D impacts the maintenance duration distributions for at-power operations, making them longer. This, in turn, increases the unavailability due to maintenance in the systems analysis. As for T, overly-frequent surveillances can result in high system unavailability. This is because the system may be taken out of service often due to the surveillance itself and due to the repair of test-caused failures of the component. The test-caused failures include those incurred by wear and tear of the component due to the surveillances. On the other hand, as the surveillance interval increases, the component's unavailability will grow because of increased occurrences of time-dependent random failures. In that situation, the component cannot be relied upon, and accordingly the system unavailability will increase. Thus, there should be an optimal component surveillance interval in terms of the corresponding system availability. This paper aims at finding the optimal T and D which result in minimum unavailability which in turn reduces the risk. Applying the methodology in section 2 to find the values of optimal T and D for two components, i.e., safety injection pump (SIP) and turbine driven aux feedwater pump (TDAFP). Section 4 is addressing interaction between D and T. In general

  2. Optimization of Allowed Outage Time and Surveillance Test Intervals

    International Nuclear Information System (INIS)

    Al-Dheeb, Mujahed; Kang, Sunkoo; Kim, Jonghyun

    2015-01-01

    The primary purpose of surveillance testing is to assure that the components of standby safety systems will be operable when they are needed in an accident. By testing these components, failures can be detected that may have occurred since the last test or the time when the equipment was last known to be operational. The probability a system or system component performs a specified function or mission under given conditions at a prescribed time is called availability (A). Unavailability (U) as a risk measure is just the complementary probability to A(t). The increase of U means the risk is increased as well. D and T have an important impact on components, or systems, unavailability. The extension of D impacts the maintenance duration distributions for at-power operations, making them longer. This, in turn, increases the unavailability due to maintenance in the systems analysis. As for T, overly-frequent surveillances can result in high system unavailability. This is because the system may be taken out of service often due to the surveillance itself and due to the repair of test-caused failures of the component. The test-caused failures include those incurred by wear and tear of the component due to the surveillances. On the other hand, as the surveillance interval increases, the component's unavailability will grow because of increased occurrences of time-dependent random failures. In that situation, the component cannot be relied upon, and accordingly the system unavailability will increase. Thus, there should be an optimal component surveillance interval in terms of the corresponding system availability. This paper aims at finding the optimal T and D which result in minimum unavailability which in turn reduces the risk. Applying the methodology in section 2 to find the values of optimal T and D for two components, i.e., safety injection pump (SIP) and turbine driven aux feedwater pump (TDAFP). Section 4 is addressing interaction between D and T. In general

  3. A Novel Scheme for Optimal Control of a Nonlinear Delay Differential Equations Model to Determine Effective and Optimal Administrating Chemotherapy Agents in Breast Cancer.

    Science.gov (United States)

    Ramezanpour, H R; Setayeshi, S; Akbari, M E

    2011-01-01

    Determining the optimal and effective scheme for administrating the chemotherapy agents in breast cancer is the main goal of this scientific research. The most important issue here is the amount of drug or radiation administrated in chemotherapy and radiotherapy for increasing patient's survival. This is because in these cases, the therapy not only kills the tumor cells, but also kills some of the healthy tissues and causes serious damages. In this paper we investigate optimal drug scheduling effect for breast cancer model which consist of nonlinear ordinary differential time-delay equations. In this paper, a mathematical model of breast cancer tumors is discussed and then optimal control theory is applied to find out the optimal drug adjustment as an input control of system. Finally we use Sensitivity Approach (SA) to solve the optimal control problem. The goal of this paper is to determine optimal and effective scheme for administering the chemotherapy agent, so that the tumor is eradicated, while the immune systems remains above a suitable level. Simulation results confirm the effectiveness of our proposed procedure. In this paper a new scheme is proposed to design a therapy protocol for chemotherapy in Breast Cancer. In contrast to traditional pulse drug delivery, a continuous process is offered and optimized, according to the optimal control theory for time-delay systems.

  4. Optimal time interval for induction of immunologic adaptive response

    International Nuclear Information System (INIS)

    Ju Guizhi; Song Chunhua; Liu Shuzheng

    1994-01-01

    The optimal time interval between prior dose (D1) and challenge dose (D2) for the induction of immunologic adaptive response was investigated. Kunming mice were exposed to 75 mGy X-rays at a dose rate of 12.5 mGy/min. 3, 6, 12, 24 or 60 h after the prior irradiation the mice were challenged with a dose of 1.5 Gy at a dose rate of 0.33 Gy/min. 18h after D2, the mice were sacrificed for examination of immunological parameters. The results showed that with an interval of 6 h between D1 and D2, the adaptive response of the reaction of splenocytes to LPS was induced, and with an interval of 12 h the adaptive responses of spontaneous incorporation of 3 H-TdR into thymocytes and the reaction of splenocytes to Con A and LPS were induced with 75 mGy prior irradiation. The data suggested that the optimal time intervals between D1 and D2 for the induction of immunologic adaptive response were 6 h and 12 h with a D1 of 75 mGy and a D2 of 1.5 Gy. The mechanism of immunologic adaptation following low dose radiation is discussed

  5. Determination of proline in honey: comparison between official methods, optimization and validation of the analytical methodology.

    Science.gov (United States)

    Truzzi, Cristina; Annibaldi, Anna; Illuminati, Silvia; Finale, Carolina; Scarponi, Giuseppe

    2014-05-01

    The study compares official spectrophotometric methods for the determination of proline content in honey - those of the International Honey Commission (IHC) and the Association of Official Analytical Chemists (AOAC) - with the original Ough method. Results show that the extra time-consuming treatment stages added by the IHC method with respect to the Ough method are pointless. We demonstrate that the AOACs method proves to be the best in terms of accuracy and time saving. The optimized waiting time for the absorbance recording is set at 35min from the removal of reaction tubes from the boiling bath used in the sample treatment. The optimized method was validated in the matrix: linearity up to 1800mgL(-1), limit of detection 20mgL(-1), limit of quantification 61mgL(-1). The method was applied to 43 unifloral honey samples from the Marche region, Italy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Determination of optimal environmental policy for reclamation of land unearthed in lignite mines - Strategy and tactics

    Science.gov (United States)

    Batzias, Dimitris F.; Pollalis, Yannis A.

    2012-12-01

    In this paper, optimal environmental policy for reclamation of land unearthed in lignite mines is defined as a strategic target. The tactics concerning the achievement of this target, includes estimation of optimal time lag between each lignite site (which is a segment of the whole lignite field) complete exploitation and its reclamation. Subsidizing of reclamation has been determined as a function of this time lag and relevant implementation is presented for parameter values valid for the Greek economy. We proved that the methodology we have developed gives reasonable quantitative results within the norms imposed by legislation. Moreover, the interconnection between strategy and tactics becomes evident, since the former causes the latter by deduction and the latter revises the former by induction in the time course of land reclamation.

  7. Optimizing Real-Time Vaccine Allocation in a Stochastic SIR Model.

    Directory of Open Access Journals (Sweden)

    Chantal Nguyen

    Full Text Available Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in delayed vaccine deployment, and the interaction between members of different cities facilitates a wide spatial spread of infection. Limited vaccine, time delays, and interaction (or coupling of cities lead to tradeoffs that impact the overall magnitude of the epidemic. These tradeoffs mandate investigation of optimal strategies that minimize the severity of the epidemic by prioritizing allocation of vaccine to specific subpopulations. We use an SIR model to describe the disease dynamics of an epidemic which breaks out in one city and spreads to another. We solve a master equation to determine the resulting probability distribution of the final epidemic size. We then identify tradeoffs between vaccine, time delay, and coupling, and we determine the optimal vaccination protocols resulting from these tradeoffs.

  8. Time Optimal Run-time Evaluation of Distributed Timing Constraints in Process Control Software

    DEFF Research Database (Denmark)

    Drejer, N.; Kristensen, C.H.

    1993-01-01

    This paper considers run-time evaluation of an important class of constraints; Timing constraints. These appear extensively in process control systems. Timing constraints are considered in distributed systems, i.e. systems consisting of multiple autonomous nodes......

  9. Optimal and sub-optimal post-detection timing estimators for PET

    International Nuclear Information System (INIS)

    Hero, A.O.; Antoniadis, N.; Clinthorne, N.; Rogers, W.L.; Hutchins, G.D.

    1990-01-01

    In this paper the authors derive linear and non-linear approximations to the post-detection likelihood function for scintillator interaction time in nuclear particle detection systems. The likelihood function is the optimal statistic for performing detection and estimation of scintillator events and event times. The authors derive the likelihood function approximations from a statistical model for the post-detection waveform which is common in the optical communications literature and takes account of finite detector bandwidth, random gains, and thermal noise. They then present preliminary simulation results for the associated approximate maximum likelihood timing estimators which indicate that significant MSE improvements may be achieved for low post-detection signal-to-noise ratio

  10. Real-time traffic signal optimization model based on average delay time per person

    Directory of Open Access Journals (Sweden)

    Pengpeng Jiao

    2015-10-01

    Full Text Available Real-time traffic signal control is very important for relieving urban traffic congestion. Many existing traffic control models were formulated using optimization approach, with the objective functions of minimizing vehicle delay time. To improve people’s trip efficiency, this article aims to minimize delay time per person. Based on the time-varying traffic flow data at intersections, the article first fits curves of accumulative arrival and departure vehicles, as well as the corresponding functions. Moreover, this article transfers vehicle delay time to personal delay time using average passenger load of cars and buses, employs such time as the objective function, and proposes a signal timing optimization model for intersections to achieve real-time signal parameters, including cycle length and green time. This research further implements a case study based on practical data collected at an intersection in Beijing, China. The average delay time per person and queue length are employed as evaluation indices to show the performances of the model. The results show that the proposed methodology is capable of improving traffic efficiency and is very effective for real-world applications.

  11. The optimal condition of performing MTT assay for the determination of radiation sensitivity

    International Nuclear Information System (INIS)

    Hong, Semie; Kim, Il Han

    2001-01-01

    The measurement of radiation survival using a clonogenic assay, the established standard, can be difficult and time consuming. In this study, We have used the MTT assay, based on the reduction of a tetrazolium salt to a purple formazan precipitate by living cells, as a substitution for clonogenic assay and have examined the optimal condition for performing this assay in determination of radiation sensitivity. Four human cancer cell lines - PCI-1, SNU-1066, NCI-H63O and RKO cells have been used. For each cell line, a clonogenic assay and a MTT assay using Premix WST-1 solution, which is one of the tetrazolium salts and does not require washing or solubilization of the precipitate were carried out after irradiation of 0, 2, 4, 6, 8, 10 Gy, For clonogenic assay, cells in 25 cm 2 flasks were irradiated after overnight incubation and the resultant colonies containing more than 50 cells were scored after culturing the cells for 10-14 days, For MTT assay, the relationship between absorbance and cell number, optimal seeding cell number, and optimal timing of assay was determined. Then, MTT assay was performed when the irradiated cells had regained exponential growth or when the non-irradiated cells had undergone four or more doubling times. There was minimal variation in the values gained from these two methods with the standard deviation generally less than 5%, and there were no statistically significant differences between two methods according to t-test in low radiation dose (below 6 Gy). The regression analyses showed high linear correlation with the R 2 value of 0.975-0.992 between data from the two different methods. The optimal cell numbers for MTT assay were found to be dependent on plating efficiency of used cell line. Less than 300 cells/well were appropriate for cells with high plating efficiency (more than 30%). For cells with low plating efficiency (less than 30%), 500 cells/well or more were appropriate for assay. The optimal time for MTT assay was alter 6

  12. Spectrum optimization-based chaotification using time-delay feedback control

    International Nuclear Information System (INIS)

    Zhou Jiaxi; Xu Daolin; Zhang Jing; Liu Chunrong

    2012-01-01

    Highlights: ► A time-delay feedback controller is designed for chaotification. ► A spectrum optimization method is proposed to determine chaotification parameters. ► Numerical examples verify the spectrum optimization- based chaotification method. ► Engineering application in line spectrum reconfiguration is demonstrated. - Abstract: In this paper, a spectrum optimization method is developed for chaotification in conjunction with an application in line spectrum reconfiguration. A key performance index (the objective function) based on Fourier spectrum is specially devised with the idea of suppressing spectrum spikes and broadening frequency band. Minimization of the index empowered by a genetic algorithm enables to locate favorable parameters of the time-delay feedback controller, by which a line spectrum of harmonic vibration can be transformed into a broad-band continuous spectrum of chaotic motion. Numerical simulations are carried out to verify the feasibility of the method and to demonstrate its effectiveness of chaotifying a 2-DOFs linear mechanical system.

  13. Ultrasound stimulation on bone healing. The optimization of stimulation time

    International Nuclear Information System (INIS)

    Rosim, R.C.; Paulin, J.B.P.; Goncalves, R.P.

    1990-01-01

    Previous works in ultrasonic simulation of bone healing dealt with parameters optimization. Albertin (1983) studied the stimulation time and found forty minutes as ideal. However, this stimulation time was the largest one employed and remained some doubt about the most appropriated value. 30, 40, 50 and 60 minutes of stimulation time were selected, while others parameters were held constant with: pulse width in 200 μs, repetition rate in 1000 pulses per second and amplitude in 30 V. Partial incomplete transverse osteotomies were done in the middle third of radio in the right forearm of rabbits. Twenty four animals divided in four subgroups, with 6 animals each were stimulated. The daily stimulation time for each subgroup was 30, 40, 50 and minutes respectively, during 15 consecutive days. The stimulation procedure started 24 hours after surgery. After the stimulation period, radiological, histological and morphometric evaluations were done and greater bone healing was found for the 50 minutes stimulation subgroup, in them new bone was also prominent. (author)

  14. Time domain topology optimization of 3D nanophotonic devices

    DEFF Research Database (Denmark)

    Elesin, Yuriy; Lazarov, Boyan Stefanov; Jensen, Jakob Søndergaard

    2014-01-01

    We present an efficient parallel topology optimization framework for design of large scale 3D nanophotonic devices. The code shows excellent scalability and is demonstrated for optimization of broadband frequency splitter, waveguide intersection, photonic crystal-based waveguide and nanowire...

  15. Optical tracking of contrast medium bolus to optimize bolus shape and timing in dynamic computed tomography

    International Nuclear Information System (INIS)

    Eisa, Fabian; Brauweiler, Robert; Peetz, Alexander; Hupfer, Martin; Nowak, Tristan; Kalender, Willi A

    2012-01-01

    One of the biggest challenges in dynamic contrast-enhanced CT is the optimal synchronization of scan start and duration with contrast medium administration in order to optimize image contrast and to reduce the amount of contrast medium. We present a new optically based approach, which was developed to investigate and optimize bolus timing and shape. The time-concentration curve of an intravenously injected test bolus of a dye is measured in peripheral vessels with an optical sensor prior to the diagnostic CT scan. The curves can be used to assess bolus shapes as a function of injection protocols and to determine contrast medium arrival times. Preliminary results for phantom and animal experiments showed the expected linear behavior between dye concentration and absorption. The kinetics of the dye was compared to iodinated contrast medium and was found to be in good agreement. The contrast enhancement curves were reliably detected in three mice with individual bolus shapes and delay times of 2.1, 3.5 and 6.1 s, respectively. The optical sensor appears to be a promising approach to optimize injection protocols and contrast enhancement timing and is applicable to all modalities without implying any additional radiation dose. Clinical tests are still necessary. (note)

  16. Real-time spatial optimization : based on the application in wood supply chain management

    International Nuclear Information System (INIS)

    Scholz, J.

    2010-01-01

    Real-time spatial optimization - a combination of Geographical Information Science and Technology and Operations Research - is capable of generating optimized solutions to given spatial problems in real-time. The basic concepts to develop a real-time spatial optimization system are outlined in this thesis. Geographic Information Science delivers the foundations for acquiring, storing, manipulating, visualizing and analyzing spatial information. In order to develop a system that consists of several independent components the concept of Service Oriented Architectures is applied. This facilitates communication between software systems utilizing standardized services that ensure interoperability. Thus, standards in the field of Geographic Information are inevitable for real-time spatial optimization. By exploiting the ability of mobile devices to determine the own position paired with standardized services Location Based Services are created. They are of interest in order to gather real-time data from mobile devices that are of importance for the optimization process itself. To optimize a given spatial problem, the universe of discourse has to be modeled accordingly. For the problem addressed in this thesis - Wood Supply Chain management - Graph theory is used. In addition, the problem of Wood Supply Chain management can be represented by a specific mathematical problem class, the Vehicle Routing problem - specifically the Vehicle Routing Problem with Pickup and Delivery and Time Windows. To optimize this problem class, exact and approximate solution techniques exist. Exact algorithms provide optimal solutions and guarantee their optimally, whereas approximate techniques - approximation algorithms or heuristics - do not guarantee that a global optimum is found. Nevertheless, the are capable of handling large problem instances in reasonable time. For optimizing the Wood Supply Chain Adaptive Large Neighborhood Search is selected as appropriate optimization technique

  17. Determining optimal interconnection capacity on the basis of hourly demand and supply functions of electricity

    International Nuclear Information System (INIS)

    Keppler, Jan Horst; Meunier, William; Coquentin, Alexandre

    2017-01-01

    Interconnections for cross-border electricity flows are at the heart of the project to create a common European electricity market. At the time, increase in production from variable renewables clustered during a limited numbers of hours reduces the availability of existing transport infrastructures. This calls for higher levels of optimal interconnection capacity than in the past. In complement to existing scenario-building exercises such as the TYNDP that respond to the challenge of determining optimal levels of infrastructure provision, the present paper proposes a new empirically-based methodology to perform Cost-Benefit analysis for the determination of optimal interconnection capacity, using as an example the French-German cross-border trade. Using a very fine dataset of hourly supply and demand curves (aggregated auction curves) for the year 2014 from the EPEX Spot market, it constructs linearized net export (NEC) and net import demand curves (NIDC) for both countries. This allows assessing hour by hour the welfare impacts for incremental increases in interconnection capacity. Summing these welfare increases over the 8 760 hours of the year, this provides the annual total for each step increase of interconnection capacity. Confronting welfare benefits with the annual cost of augmenting interconnection capacity indicated the socially optimal increase in interconnection capacity between France and Germany on the basis of empirical market micro-data. (authors)

  18. Optimal harvesting of fish stocks under a time-varying discount rate.

    Science.gov (United States)

    Duncan, Stephen; Hepburn, Cameron; Papachristodoulou, Antonis

    2011-01-21

    Optimal control theory has been extensively used to determine the optimal harvesting policy for renewable resources such as fish stocks. In such optimisations, it is common to maximise the discounted utility of harvesting over time, employing a constant time discount rate. However, evidence from human and animal behaviour suggests that we have evolved to employ discount rates which fall over time, often referred to as "hyperbolic discounting". This increases the weight on benefits in the distant future, which may appear to provide greater protection of resources for future generations, but also creates challenges of time-inconsistent plans. This paper examines harvesting plans when the discount rate declines over time. With a declining discount rate, the planner reduces stock levels in the early stages (when the discount rate is high) and intends to compensate by allowing the stock level to recover later (when the discount rate will be lower). Such a plan may be feasible and optimal, provided that the planner remains committed throughout. However, in practice there is a danger that such plans will be re-optimized and adjusted in the future. It is shown that repeatedly restarting the optimization can drive the stock level down to the point where the optimal policy is to harvest the stock to extinction. In short, a key contribution of this paper is to identify the surprising severity of the consequences flowing from incorporating a rather trivial, and widely prevalent, "non-rational" aspect of human behaviour into renewable resource management models. These ideas are related to the collapse of the Peruvian anchovy fishery in the 1970's. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Optimal Application Timing of Pest Control Tactics in Nonautonomous Pest Growth Model

    OpenAIRE

    Zhang, Shujuan; Liang, Juhua; Tang, Sanyi

    2014-01-01

    Considering the effects of the living environment on growth of populations, it is unrealistic to assume that the growth rates of predator and prey are all constants in the models with integrated pest management (IPM) strategies. Therefore, a nonautonomous predator-prey system with impulsive effect is developed and investigated in the present work. In order to determine the optimal application timing of IPM tactics, the threshold value which guarantees the stability of pest-free periodic solut...

  20. Time optimization of 90Sr measurements: Sequential measurement of multiple samples during ingrowth of 90Y

    International Nuclear Information System (INIS)

    Holmgren, Stina; Tovedal, Annika; Björnham, Oscar; Ramebäck, Henrik

    2016-01-01

    The aim of this paper is to contribute to a more rapid determination of a series of samples containing 90 Sr by making the Cherenkov measurement of the daughter nuclide 90 Y more time efficient. There are many instances when an optimization of the measurement method might be favorable, such as; situations requiring rapid results in order to make urgent decisions or, on the other hand, to maximize the throughput of samples in a limited available time span. In order to minimize the total analysis time, a mathematical model was developed which calculates the time of ingrowth as well as individual measurement times for n samples in a series. This work is focused on the measurement of 90 Y during ingrowth, after an initial chemical separation of strontium, in which it is assumed that no other radioactive strontium isotopes are present. By using a fixed minimum detectable activity (MDA) and iterating the measurement time for each consecutive sample the total analysis time will be less, compared to using the same measurement time for all samples. It was found that by optimization, the total analysis time for 10 samples can be decreased greatly, from 21 h to 6.5 h, when assuming a MDA of 1 Bq/L and at a background count rate of approximately 0.8 cpm. - Highlights: • An approach roughly a factor of three more efficient than an un-optimized method. • The optimization gives a more efficient use of instrument time. • The efficiency increase ranges from a factor of three to 10, for 10 to 40 samples.

  1. The Effects of Creatine Supplementation on Explosive Performance and Optimal Individual Postactivation Potentiation Time

    Directory of Open Access Journals (Sweden)

    Chia-Chi Wang

    2016-03-01

    Full Text Available Creatine plays an important role in muscle energy metabolism. Postactivation potentiation (PAP is a phenomenon that can acutely increase muscle power, but it is an individualized process that is influenced by muscle fatigue. This study examined the effects of creatine supplementation on explosive performance and the optimal individual PAP time during a set of complex training bouts. Thirty explosive athletes performed tests of back squat for one repetition maximum (1RM strength and complex training bouts for determining the individual optimal timing of PAP, height and peak power of a counter movement jump before and after the supplementation. Subjects were assigned to a creatine or placebo group and then consumed 20 g of creatine or carboxymethyl cellulose per day for six days. After the supplementation, the 1RM strength in the creatine group significantly increased (p < 0.05. The optimal individual PAP time in the creatine group was also significant earlier than the pre-supplementation and post-supplementation of the placebo group (p < 0.05. There was no significant difference in jump performance between the groups. This study demonstrates that creatine supplementation improves maximal muscle strength and the optimal individual PAP time of complex training but has no effect on explosive performance.

  2. Time regimes optimization of the activation-measurement cycle in neutron activation analysis

    International Nuclear Information System (INIS)

    Szopa, Z.

    1986-01-01

    Criteria of the optimum time conditions of the activation-measurement cycle in neutron activation analysis have been formulated. The optimized functions i.e. the relative precision or the factor of ''merit'' of the analytical signal measured as functions of the cycle time parameters have been proposed. The structure and possibilities of the optimizing programme STOPRC have been presented. This programme is completely written in FORTRAN and takes advantage of the library of standard spectra and fast, stochastic algorithms. The time conditions predicted with the aid of the programme have been discussed and compared with the experimental results for the case of the determination of tungsten in industrial dusts. 31 refs., 4 figs. (author)

  3. Topologically determined optimal stochastic resonance responses of spatially embedded networks

    International Nuclear Information System (INIS)

    Gosak, Marko; Marhl, Marko; Korosak, Dean

    2011-01-01

    We have analyzed the stochastic resonance phenomenon on spatial networks of bistable and excitable oscillators, which are connected according to their location and the amplitude of external forcing. By smoothly altering the network topology from a scale-free (SF) network with dominating long-range connections to a network where principally only adjacent oscillators are connected, we reveal that besides an optimal noise intensity, there is also a most favorable interaction topology at which the best correlation between the response of the network and the imposed weak external forcing is achieved. For various distributions of the amplitudes of external forcing, the optimal topology is always found in the intermediate regime between the highly heterogeneous SF network and the strong geometric regime. Our findings thus indicate that a suitable number of hubs and with that an optimal ratio between short- and long-range connections is necessary in order to obtain the best global response of a spatial network. Furthermore, we link the existence of the optimal interaction topology to a critical point indicating the transition from a long-range interactions-dominated network to a more lattice-like network structure.

  4. Use of Simplex Method in Determination of Optimal Rational ...

    African Journals Online (AJOL)

    The optimal rational composition was found to be: Nsu Clay = 47.8%, quartz = 33.7% and CaCO3 = 18.5%. The other clay from Ukpor was found unsuitable at the firing temperature (l000°C) used. It showed bending strength lower than the standard requirement for all compositions studied. To improve the strength an ...

  5. Optimal International Asset Allocation with Time-varying Risk

    OpenAIRE

    Flavin, Thomas; Wickens, M.R.

    2006-01-01

    This paper examines the optimal allocation each period of an internationally diversified portfolio from the different points of view of a UK and a US investor. We find that investor location affects optimal asset allocation. The presence of exchange rate risk causes the markets to appear not fully integrated and creates a preference for home assets. Domestic equity is the dominant asset in the optimal portfolio for both investors, but the US investor bears less risk than the UK...

  6. Analysis and Optimization of Distributed Real-Time Embedded Systems

    DEFF Research Database (Denmark)

    Pop, Paul; Eles, Petru; Peng, Zebo

    2006-01-01

    and scheduling policies. In this context, the task of designing such systems is becoming increasingly difficult. The success of new adequate design methods depends on the availability of efficient analysis as well as optimization techniques. In this paper, we present both analysis and optimization approaches...... characteristic to this class of systems: mapping of functionality, the optimization of the access to the communication channel, and the assignment of scheduling policies to processes. Optimization heuristics aiming at producing a schedulable system, with a given amount of resources, are presented....

  7. The Optimization of Passengers’ Travel Time under Express-Slow Mode Based on Suburban Line

    Directory of Open Access Journals (Sweden)

    Xiaobing Ding

    2016-01-01

    Full Text Available The suburban line connects the suburbs and the city centre; it is of huge advantage to attempt the express-slow mode. The passengers’ average travel time is the key factor to reflect the level of rail transport services, especially under the express-slow mode. So it is important to study the passengers’ average travel time under express-slow, which can get benefit on the optimization of operation scheme. First analyze the main factor that affects passengers’ travel time and then mine the dynamic interactive relationship among the factors. Second, a new passengers’ travel time evolution algorithm is proposed after studying the stop schedule and the proportion of express/slow train, and then membrane computing theory algorithm is introduced to solve the model. Finally, Shanghai Metro Line 22 is set as an example to apply the optimization model to calculate the total passengers’ travel time; the result shows that the total average travel time under the express-slow mode can save 1 minute and 38 seconds; the social influence and value of it are very huge. The proposed calculation model is of great help for the decision of stop schedule and provides theoretical and methodological support to determine the proportion of express/slow trains, improves the service level, and enriches and complements the rail transit operation scheme optimization theory system.

  8. DETERMINATION OF THE OPTIMAL CAPITAL INVESTMENTS TO ENSURE THE SUSTAINABLE DEVELOPMENT OF THE RAILWAY

    Directory of Open Access Journals (Sweden)

    O. I. Kharchenko

    2015-04-01

    Full Text Available Purpose. Every year more attention is paid for the theoretical and practical issue of sustainable development of railway transport. But today the mechanisms of financial support of this development are poorly understood. Therefore, the aim of this article is to determine the optimal investment allocation to ensure sustainable development of the railway transport on the example of State Enterprise «Prydniprovsk Railway» and the creation of preconditions for the mathematical model development. Methodology. The ensuring task for sustainable development of railway transport is solved on the basis of the integral indicator of sustainable development effectiveness and defined as the maximization of this criterion. The optimization of measures technological and technical characters are proposed to carry out for increasing values of the integral performance measure components. To the optimization activities of technological nature that enhance the performance criteria belongs: optimization of the number of train and shunting locomotives, optimization of power handling mechanisms at the stations, optimization of routes of train flows. The activities related to the technical nature include: modernization of railways in the direction of their electrification and modernization of the running gear and coupler drawbars of rolling stock, as well as means of separators mechanization at stations to reduce noise impacts on the environment. Findings. The work resulted in the optimal allocation of investments to ensure the sustainable development of railway transportation of State Enterprise «Prydniprovsk Railway». This allows providing such kind of railway development when functioning of State Enterprise «Prydniprovsk Railway» is characterized by a maximum value of the integral indicator of efficiency. Originality. The work was reviewed and the new approach was proposed to determine the optimal allocation of capital investments to ensure sustainable

  9. Determination of the Optimal Tilt Angle for Solar Photovoltaic Panel in Ilorin, Nigeria

    Directory of Open Access Journals (Sweden)

    K.R. Ajao

    2013-06-01

    Full Text Available The optimal tilt angle of solar photovoltaic panel in Ilorin, Nigeria was determined. The solar panel was first mounted at 0o to the horizontal and after ten minutes, the voltage and current generated with the corresponding atmospheric temperature were recorded. The same procedure was repeated for 2o to 30o at a succession of 2o at ten minutes time interval over the entire measurement period. The result obtained shows that the average optimal tilt angle at which a solar panel will be mounted for maximum power performance at fixed position in Ilorin is 22o. This optimum angle of tilt of the solar panel and the orientation are dependent on the month of the year and the location of the site of study.

  10. Ambush frequency should increase over time during optimal predator search for prey.

    Science.gov (United States)

    Alpern, Steve; Fokkink, Robbert; Timmer, Marco; Casas, Jérôme

    2011-11-07

    We advance and apply the mathematical theory of search games to model the problem faced by a predator searching for prey. Two search modes are available: ambush and cruising search. Some species can adopt either mode, with their choice at a given time traditionally explained in terms of varying habitat and physiological conditions. We present an additional explanation of the observed predator alternation between these search modes, which is based on the dynamical nature of the search game they are playing: the possibility of ambush decreases the propensity of the prey to frequently change locations and thereby renders it more susceptible to the systematic cruising search portion of the strategy. This heuristic explanation is supported by showing that in a new idealized search game where the predator is allowed to ambush or search at any time, and the prey can change locations at intermittent times, optimal predator play requires an alternation (or mixture) over time of ambush and cruise search. Thus, our game is an extension of the well-studied 'Princess and Monster' search game. Search games are zero sum games, where the pay-off is the capture time and neither the Searcher nor the Hider knows the location of the other. We are able to determine the optimal mixture of the search modes when the predator uses a mixture which is constant over time, and also to determine how the mode mixture changes over time when dynamic strategies are allowed (the ambush probability increases over time). In particular, we establish the 'square root law of search predation': the optimal proportion of active search equals the square root of the fraction of the region that has not yet been explored.

  11. How to decide the optimal scheme and the optimal time for construction

    International Nuclear Information System (INIS)

    Gjermundsen, T.; Dalsnes, B.; Jensen, T.

    1991-01-01

    Since the development in Norway began some 105 years ago the mean annual generation has reached approximately 110 TWh. This means that there is a large potential for uprating and refurbishing (U/R). A project undertaken by the Norwegian Water Resources and Energy Administration (NVE) has identified energy resources by means of U/R to about 10 TWh annual generation. One problem in harnessing the potential owned by small and medium sized electricity boards is the lack of simple tools to help us carry out the right decisions. The paper describes a simple model to find the best solution of scheme and the optimal time to start. The principle of present value is used. The main input is: production, price, annual costs of maintenance, the remaining lifetime and the social rate of return. The model calculates the present value of U/R/N for different points of time to start U/R/N. In addition the present value of the existing plant is calculated. Several alternatives can be considered. The best one will be the one which gives the highest present value according to the value of the existing plant. The internal rate of return is also calculated. To be aware of the sensitivity a star diagram is shown. The model gives the opportunity to include environmental charges and the value of effect (peak power). (Author)

  12. Determination of optimal self-drive tourism route using the orienteering problem method

    Science.gov (United States)

    Hashim, Zakiah; Ismail, Wan Rosmanira; Ahmad, Norfaieqah

    2013-04-01

    This paper was conducted to determine the optimal travel routes for self-drive tourism based on the allocation of time and expense by maximizing the amount of attraction scores assigned to each city involved. Self-drive tourism represents a type of tourism where tourists hire or travel by their own vehicle. It only involves a tourist destination which can be linked with a network of roads. Normally, the traveling salesman problem (TSP) and multiple traveling salesman problems (MTSP) method were used in the minimization problem such as determination the shortest time or distance traveled. This paper involved an alternative approach for maximization method which is maximize the attraction scores and tested on tourism data for ten cities in Kedah. A set of priority scores are used to set the attraction score at each city. The classical approach of the orienteering problem was used to determine the optimal travel route. This approach is extended to the team orienteering problem and the two methods were compared. These two models have been solved by using LINGO12.0 software. The results indicate that the model involving the team orienteering problem provides a more appropriate solution compared to the orienteering problem model.

  13. Combustion characteristics and optimal factors determination with Taguchi method for diesel engines port-injecting hydrogen

    International Nuclear Information System (INIS)

    Wu, Horng-Wen; Wu, Zhan-Yi

    2012-01-01

    This study applies the L 9 orthogonal array of the Taguchi method to find out the best hydrogen injection timing, hydrogen-energy-share ratio, and the percentage of exhaust gas circulation (EGR) in a single DI diesel engine. The injection timing is controlled by an electronic control unit (ECU) and the quantity of hydrogen is controlled by hydrogen flow controller. For various engine loads, the authors determine the optimal operating factors for low BSFC (brake specific fuel consumption), NO X , and smoke. Moreover, net heat-release rate involving variable specific heat ratio is computed from the experimental in-cylinder pressure. In-cylinder pressure, net heat-release rate, A/F ratios, COV (coefficient of variations) of IMEP (indicated mean effective pressure), NO X , and smoke using the optimum condition factors are compared with those by original baseline diesel engine. The predictions made using Taguchi's parameter design technique agreed with the confirmation results on 95% confidence interval. At 45% and 60% loads the optimum factor combination compared with the original baseline diesel engine reduces 14.52% for BSFC, 60.5% for NO X and for 42.28% smoke and improves combustion performance such as peak in-cylinder pressure and net heat-release rate. Adding hydrogen and EGR would not generate unstable combustion due to lower COV of IMEP. -- Highlights: ► We use hydrogen injector controlled by ECU and cooled EGR system in a diesel engine. ► Optimal factors by Taguchi method are determined for low BSFC, NO X and smoke. ► The COV of IMEP is lower than 10% so it will not cause the unstable combustion. ► We improve A/F ratio, in-cylinder pressure, and heat-release at optimized engine. ► Decrease is 14.5% for BSFC, 60.5% for NO X , and 42.28% for smoke at optimized engine.

  14. Optimization of Modulator and Circuits for Low Power Continuous-Time Delta-Sigma ADC

    DEFF Research Database (Denmark)

    Marker-Villumsen, Niels; Bruun, Erik

    2014-01-01

    This paper presents a new optimization method for achieving a minimum current consumption in a continuous-time Delta-Sigma analog-to-digital converter (ADC). The method is applied to a continuous-time modulator realised with active-RC integrators and with a folded-cascode operational transconduc...... levels are swept. Based on the results of the circuit analysis, for each modulator combination the summed current consumption of the 1st integrator and quantizer of the ADC is determined. By also sweeping the partitioning of the noise power for the different circuit parts, the optimum modulator...

  15. Time-optimal control of nuclear reactor power with adaptive proportional- integral-feedforward gains

    International Nuclear Information System (INIS)

    Park, Moon Ghu; Cho, Nam Zin

    1993-01-01

    A time-optimal control method which consists of coarse and fine control stages is described here. During the coarse control stage, the maximum control effort (time-optimal) is used to direct the system toward the switching boundary which is set near the desired power level. At this boundary, the controller is switched to the fine control stage in which an adaptive proportional-integral-feedforward (PIF) controller is used to compensate for any unmodeled reactivity feedback effects. This fine control is also introduced to obtain a constructive method for determining the (adaptive) feedback gains against the sampling effect. The feedforward control term is included to suppress the over-or undershoot. The estimation and feedback of the temperature-induced reactivity is also discussed

  16. Evaluation of sample preparation methods and optimization of nickel determination in vegetable tissues

    Directory of Open Access Journals (Sweden)

    Rodrigo Fernando dos Santos Salazar

    2011-02-01

    Full Text Available Nickel, although essential to plants, may be toxic to plants and animals. It is mainly assimilated by food ingestion. However, information about the average levels of elements (including Ni in edible vegetables from different regions is still scarce in Brazil. The objectives of this study were to: (a evaluate and optimize a method for preparation of vegetable tissue samples for Ni determination; (b optimize the analytical procedures for determination by Flame Atomic Absorption Spectrometry (FAAS and by Electrothermal Atomic Absorption (ETAAS in vegetable samples and (c determine the Ni concentration in vegetables consumed in the cities of Lorena and Taubaté in the Vale do Paraíba, State of São Paulo, Brazil. By means of the analytical technique for determination by ETAAS or FAAS, the results were validated by the test of analyte addition and recovery. The most viable method tested for quantification of this element was HClO4-HNO3 wet digestion. All samples but carrot tissue collected in Lorena contained Ni levels above the permitted by the Brazilian Ministry of Health. The most disturbing results, requiring more detailed studies, were the Ni concentrations measured in carrot samples from Taubaté, where levels were five times higher than permitted by Brazilian regulations.

  17. Optimization of NANOGrav's time allocation for maximum sensitivity to single sources

    International Nuclear Information System (INIS)

    Christy, Brian; Anella, Ryan; Lommen, Andrea; Camuccio, Richard; Handzo, Emma; Finn, Lee Samuel

    2014-01-01

    Pulsar timing arrays (PTAs) are a collection of precisely timed millisecond pulsars (MSPs) that can search for gravitational waves (GWs) in the nanohertz frequency range by observing characteristic signatures in the timing residuals. The sensitivity of a PTA depends on the direction of the propagating GW source, the timing accuracy of the pulsars, and the allocation of the available observing time. The goal of this paper is to determine the optimal time allocation strategy among the MSPs in the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) for a single source of GW under a particular set of assumptions. We consider both an isotropic distribution of sources across the sky and a specific source in the Virgo cluster. This work improves on previous efforts by modeling the effect of intrinsic spin noise for each pulsar. We find that, in general, the array is optimized by maximizing time spent on the best-timed pulsars, with sensitivity improvements typically ranging from a factor of 1.5 to 4.

  18. Evaluation of Effective Factors on Travel Time in Optimization of Bus Stops Placement Using Genetic Algorithm

    Science.gov (United States)

    Bargegol, Iraj; Ghorbanzadeh, Mahyar; Ghasedi, Meisam; Rastbod, Mohammad

    2017-10-01

    In congested cities, locating and proper designing of bus stops according to the unequal distribution of passengers is crucial issue economically and functionally, since this subject plays an important role in the use of bus system by passengers. Location of bus stops is a complicated subject; by reducing distances between stops, walking time decreases, but the total travel time may increase. In this paper, a specified corridor in the city of Rasht in north of Iran is studied. Firstly, a new formula is presented to calculate the travel time, by which the number of stops and consequently, the travel time can be optimized. An intended corridor with specified number of stops and distances between them is addressed, the related formulas to travel time are created, and its travel time is calculated. Then the corridor is modelled using a meta-heuristic method in order that the placement and the optimal distances of bus stops for that are determined. It was found that alighting and boarding time along with bus capacity are the most effective factors affecting travel time. Consequently, it is better to have more concentration on indicated factors for improving the efficiency of bus system.

  19. Real-Time Game Adaptation for Optimizing Player Satisfaction

    DEFF Research Database (Denmark)

    Yannakakis, Georgios; Hallam, John

    2009-01-01

    A methodology for optimizing player satisfaction in games on the "playware" physical interactive platform is demonstrated in this paper. Previously constructed artificial neural network user models, reported in the literature, map individual playing characteristics to reported entertainment...

  20. Optimized determination of the radiological inventory during different phases of decommissioning

    International Nuclear Information System (INIS)

    Hillberg, Matthias; Beltz, Detlef; Karschnick, Oliver

    2012-01-01

    The decommissioning of nuclear facilities comprises a lot of activities such as decontamination, dismantling and demolition of equipment and structures. For these activities the aspects of health and safety of the operational personnel and of the general public as well as the minimization of radioactive waste have to be taken into account. An optimized, comprehensible and verifiable determination of the radiological inventory is essential for the decommissioning management with respect to safety, time, and costs. For example: right from the start of the post operational phase, the radiological characterization has to enable the decision whether to perform a system decontamination or not. Furthermore it is necessary, e.g. to determine the relevant nuclides and their composition (nuclide vector) for the release of material and for sustaining the radiological health and safety at work (e. g. minimizing the risk of incorporation). Our contribution will focus on the optimization of the radiological characterization with respect to the requisite extent and the best instant of time during the decommissioning process. For example: which additional information, besides the history of operation, is essential for an adequate amount of sampling and measurements needed in order to determine the relevant nuclides and their compositions? Furthermore, the characterization of buildings requires a kind of a graded approach during the decommissioning process. At the beginning of decommissioning, only a rough estimate of the expected radioactive waste due to the necessary decontamination of the building structures is sufficient. With ongoing decommissioning, a more precise radiological characterization of buildings is needed in order to guarantee an optimized, comprehensible and verifiable decontamination, dismantling and trouble-free clearance. These and other examples will be discussed on the background of and with reference to different decommissioning projects involving direct

  1. Computer-generated versus nurse-determined strategy for incubator humidity and time to regain birthweight

    NARCIS (Netherlands)

    Helder, Onno K.; Mulder, Paul G. H.; van Goudoever, Johannes B.

    2008-01-01

    To compare effects on premature infants' weight gain of a computer-generated and a nurse-determined incubator humidity strategy. An optimal humidity protocol is thought to reduce time to regain birthweight. Prospective randomized controlled design. Level IIIC neonatal intensive care unit in the

  2. Note: Optimal base-stock policy for the inventory system with periodic review, backorders and sequential lead times

    DEFF Research Database (Denmark)

    Johansen, Søren Glud; Thorstenson, Anders

    We show that well-known textbook formulae for determining the optimal base stock of the inventory system with continuous review and constant lead time can easily be extended to the case with periodic review and stochastic, sequential lead times. The provided performance measures and conditions...

  3. Determination and optimization of spatial samples for distributed measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Huo, Xiaoming (Georgia Institute of Technology, Atlanta, GA); Tran, Hy D.; Shilling, Katherine Meghan; Kim, Heeyong (Georgia Institute of Technology, Atlanta, GA)

    2010-10-01

    There are no accepted standards for determining how many measurements to take during part inspection or where to take them, or for assessing confidence in the evaluation of acceptance based on these measurements. The goal of this work was to develop a standard method for determining the number of measurements, together with the spatial distribution of measurements and the associated risks for false acceptance and false rejection. Two paths have been taken to create a standard method for selecting sampling points. A wavelet-based model has been developed to select measurement points and to determine confidence in the measurement after the points are taken. An adaptive sampling strategy has been studied to determine implementation feasibility on commercial measurement equipment. Results using both real and simulated data are presented for each of the paths.

  4. The optimization of scan timing for contrast-enhanced magnetic resonance angiography

    International Nuclear Information System (INIS)

    Lee, Jong Min; Chang, Yong Min; Ryeom, Hun Kyu; Lee, Sang Kwon; Kim, Yong Sun; Kang, Duk Sik; Tirman, Philip J.

    2000-01-01

    To determine the optimal scan timing for contrast-enhanced magnetic resonance angiography and to evaluate a new timing method based on the arteriovenous circulation time. Eighty-nine contrast-enhanced magnetic resonance angiographic examinations were performed mainly in the extremities. A 1.5T scanner with a 3-D turbo-FLASH sequence was used, and during each study, two consecutive arterial phases and one venous phase were acquired. Scan delay time was calculated from the time-intensity curve by the traditional (n = 48) and/or the new (n = 41) method. This latter was based on arteriovenous circulation time rather than peak arterial enhancement time, as used in the traditional method. The numbers of first-phase images showing a properly enhanced arterial phase were compared between the two methods. Mean scan delay time was 5.4 sec longer with the new method than with the traditional. Properly enhanced first-phase images were found in 65% of cases (31/48) using the traditional timing method, and 95% (39/41) using the new method. When cases in which there was mismatch between the target vessel and the Time-intensity curve acquisition site are excluded, erroneous acquisition occurred in seven cases with the traditional method, but in none with the new method. The calculation of scan delay time on the basis of arteriovenous circulation time provides better timing for arterial phase acquisition than the traditional method

  5. The determinants of part-time work in Metropolitan Lima

    OpenAIRE

    Manuel Enrique Saavedra Martinez

    2011-01-01

    The following paper examines the part-time work in Metropolitan Lima in 2008. The overall objective is to identify the determinants of the incidence of part-time work in Lima. We worked with one Probit econometric model, measured by the National Survey of Households (NSH), which explores the job characteristics of people. This will determine the presence of part-time workers in the areas of trade, health, education and communication; also realized that this group has completed university stud...

  6. The determinants of part-time work in Metropolitan Lima

    OpenAIRE

    Saavedra Martinez, Manuel Enrique

    2012-01-01

    The following paper examines the part-time work in Metropolitan Lima in 2008. The overall objective is to identify the determinants of the incidence of part-time work in Lima. We worked with one Probit econometric model, measured by the National Survey of Households (NSH), which explores the job characteristics of people. This will determine the presence of part-time workers in the areas of trade, health, education and communication; also realized that this group has completed university stud...

  7. Time optimized path-choice in the termite hunting ant Megaponera analis.

    Science.gov (United States)

    Frank, Erik T; Hönle, Philipp O; Linsenmair, K Eduard

    2018-05-10

    Trail network systems among ants have received a lot of scientific attention due to their various applications in problem solving of networks. Recent studies have shown that ants select the fastest available path when facing different velocities on different substrates, rather than the shortest distance. The progress of decision-making by these ants is determined by pheromone-based maintenance of paths, which is a collective decision. However, path optimization through individual decision-making remains mostly unexplored. Here we present the first study of time-optimized path selection via individual decision-making by scout ants. Megaponera analis scouts search for termite foraging sites and lead highly organized raid columns to them. The path of the scout determines the path of the column. Through installation of artificial roads around M. analis nests we were able to influence the pathway choice of the raids. After road installation 59% of all recorded raids took place completely or partly on the road, instead of the direct, i.e. distance-optimized, path through grass from the nest to the termites. The raid velocity on the road was more than double the grass velocity, the detour thus saved 34.77±23.01% of the travel time compared to a hypothetical direct path. The pathway choice of the ants was similar to a mathematical model of least time allowing us to hypothesize the underlying mechanisms regulating the behavior. Our results highlight the importance of individual decision-making in the foraging behavior of ants and show a new procedure of pathway optimization. © 2018. Published by The Company of Biologists Ltd.

  8. Optimization and validation of Folin-Ciocalteu method for the determination of total polyphenol content of Pu-erh tea.

    Science.gov (United States)

    Musci, Marilena; Yao, Shicong

    2017-12-01

    Pu-erh tea is a post-fermented tea that has recently gained popularity worldwide, due to potential health benefits related to the antioxidant activity resulting from its high polyphenolic content. The Folin-Ciocalteu method is a simple, rapid, and inexpensive assay widely applied for the determination of total polyphenol content. Over the past years, it has been subjected to many modifications, often without any systematic optimization or validation. In our study, we sought to optimize the Folin-Ciocalteu method, evaluate quality parameters including linearity, precision and stability, and then apply the optimized model to determine the total polyphenol content of 57 Chinese teas, including green tea, aged and ripened Pu-erh tea. Our optimized Folin-Ciocalteu method reduced analysis time, allowed for the analysis of a large number of samples, to discriminate among the different teas, and to assess the effect of the post-fermentation process on polyphenol content.

  9. Optimal control methods for rapidly time-varying Hamiltonians

    International Nuclear Information System (INIS)

    Motzoi, F.; Merkel, S. T.; Wilhelm, F. K.; Gambetta, J. M.

    2011-01-01

    In this article, we develop a numerical method to find optimal control pulses that accounts for the separation of timescales between the variation of the input control fields and the applied Hamiltonian. In traditional numerical optimization methods, these timescales are treated as being the same. While this approximation has had much success, in applications where the input controls are filtered substantially or mixed with a fast carrier, the resulting optimized pulses have little relation to the applied physical fields. Our technique remains numerically efficient in that the dimension of our search space is only dependent on the variation of the input control fields, while our simulation of the quantum evolution is accurate on the timescale of the fast variation in the applied Hamiltonian.

  10. A Demonstration of Optimal Apodization Determination for Proper Lateral Modulation

    Science.gov (United States)

    Sumi, Chikayoshi; Komiya, Yuichi; Uga, Shinya

    2009-07-01

    We have realized effective ultrasound (US) beamformings by the steering of plural beams and apodizations for B-mode imaging with a high lateral resolution and accurate measurement of tissue or blood displacement vector and/or strain tensor using the multidimensional cross-spectrum phase gradient method (MCSPGM), or multidimensional autocorrelation or Doppler methods (MAM and MDM) using multidimensional analytic signals. For instance, the coherent superposition of the steered beams performed in the lateral cosine modulation method (LCM) has a higher potential for realizing a more accurate measurement of a displacement vector than the synthesis of the displacement vector using the accurately measured axial displacements obtained by the multidimensional synthetic aperture method (MDSAM), multidirectional transmission method (MTM) or the use of plural US transducers. Originally, the apodization function to be used for realizing a designed point spread function (PSF) was obtained by the Fraunhofer approximation (FA). However, to obtain the best approximated, designed PSF in the least-squares sense, we proposed a linear optimization (LO) method. Furthermore, on the basis of the knowledge about the losts of US energy during the propagation, we have recently developed a nonlinear optimization (NLO) method, in which the feet of the main lobes in apodization function are properly truncated. Thus, NLO also allows the decrease in the number of channels or the confinement of the effective aperture. In this study, to gain insight into the ideal shape of the PSF, the accuracies of the two-dimensional (2D) displacement vector measurements were compared for typical PSFs with distinct lateral envelope shapes, particularly, in terms of full width at half maximum (FWHM) and the length of the feet, i.e., the Gaussian function, Hanning window and parabolic function. It was confirmed that a PSF having a wide FWHM and short feet was ideal. Such a PSF yielded an echo with a high signal

  11. A projection method for under determined optimal experimental designs

    KAUST Repository

    Long, Quan; Scavino, Marco; Tempone, Raul; Wang, Suojin

    2014-01-01

    A new implementation, based on the Laplace approximation, was developed in (Long, Scavino, Tempone, & Wang 2013) to accelerate the estimation of the post–experimental expected information gains in the model parameters and predictive quantities of interest. A closed–form approximation of the inner integral and the order of the corresponding dominant error term were obtained in the cases where the parameters are determined by the experiment. In this work, we extend that method to the general cases where the model parameters could not be determined completely by the data from the proposed experiments. We carry out the Laplace approximations in the directions orthogonal to the null space of the corresponding Jacobian matrix, so that the information gain (Kullback–Leibler divergence) can be reduced to an integration against the marginal density of the transformed parameters which are not determined by the experiments. Furthermore, the expected information gain can be approximated by an integration over the prior, where the integrand is a function of the projected posterior covariance matrix. To deal with the issue of dimensionality in a complex problem, we use Monte Carlo sampling or sparse quadratures for the integration over the prior probability density function, depending on the regularity of the integrand function. We demonstrate the accuracy, efficiency and robustness of the proposed method via several nonlinear under determined numerical examples.

  12. A projection method for under determined optimal experimental designs

    KAUST Repository

    Long, Quan

    2014-01-09

    A new implementation, based on the Laplace approximation, was developed in (Long, Scavino, Tempone, & Wang 2013) to accelerate the estimation of the post–experimental expected information gains in the model parameters and predictive quantities of interest. A closed–form approximation of the inner integral and the order of the corresponding dominant error term were obtained in the cases where the parameters are determined by the experiment. In this work, we extend that method to the general cases where the model parameters could not be determined completely by the data from the proposed experiments. We carry out the Laplace approximations in the directions orthogonal to the null space of the corresponding Jacobian matrix, so that the information gain (Kullback–Leibler divergence) can be reduced to an integration against the marginal density of the transformed parameters which are not determined by the experiments. Furthermore, the expected information gain can be approximated by an integration over the prior, where the integrand is a function of the projected posterior covariance matrix. To deal with the issue of dimensionality in a complex problem, we use Monte Carlo sampling or sparse quadratures for the integration over the prior probability density function, depending on the regularity of the integrand function. We demonstrate the accuracy, efficiency and robustness of the proposed method via several nonlinear under determined numerical examples.

  13. Determining optimal pinger spacing for harbour porpoise bycatch mitigation

    DEFF Research Database (Denmark)

    Larsen, Finn; Krog, Carsten; Eigaard, Ole Ritzau

    2013-01-01

    A trial was conducted in the Danish North Sea hake gillnet fishery in July to September 2006 to determine whether the spacing of the Aquatec AQUAmark100 pinger could be increased without reducing the effectiveness of the pinger in mitigating harbour porpoise bycatch. The trial was designed as a c...

  14. Reliability Of A Novel Intracardiac Electrogram Method For AV And VV Delay Optimization And Comparability To Echocardiography Procedure For Determining Optimal Conduction Delays In CRT Patients

    Directory of Open Access Journals (Sweden)

    N Reinsch

    2009-03-01

    Full Text Available Background: Echocardiography is widely used to optimize CRT programming. A novel intracardiac electrogram method (IEGM was recently developed as an automated programmer-based method, designed to calculate optimal atrioventricular (AV and interventricular (VV delays and provide optimized delay values as an alternative to standard echocardiographic assessment.Objective: This study was aimed at determining the reliability of this new method. Furthermore the comparability of IEGM to existing echocardiographic parameters for determining optimal conduction delays was verified.Methods: Eleven patients (age 62.9± 8.7; 81% male; 73% ischemic, previously implanted with a cardiac resynchronisation therapy defibrillator (CRT-D underwent both echocardiographic and IEGM-based delay optimization.Results: Applying the IEGM method, concordance of three consecutively performed measurements was found in 3 (27% patients for AV delay and in 5 (45% patients for VV delay. Intra-individual variation between three measurements as assessed by the IEGM technique was up to 20 ms (AV: n=6; VV: n=4. E-wave, diastolic filling time and septal-to-lateral wall motion delay emerged as significantly different between the echo and IEGM optimization techniques (p < 0.05. The final AV delay setting was significantly different between both methods (echo: 126.4 ± 29.4 ms, IEGM: 183.6 ± 16.3 ms; p < 0.001; correlation: R = 0.573, p = 0.066. VV delay showed significant differences for optimized delays (echo: 46.4 ± 23.8 ms, IEGM: 10.9 ± 7.0 ms; p <0.01; correlation: R = -0.278, p = 0.407.Conclusion: The automated programmer-based IEGM-based method provides a simple and safe method to perform CRT optimization. However, the reliability of this method appears to be limited. Thus, it remains difficult for the examiner to determine the optimal hemodynamic settings. Additionally, as there was no correlation between the optimal AV- and VV-delays calculated by the IEGM method and the echo

  15. Testing for intracycle determinism in pseudoperiodic time series.

    Science.gov (United States)

    Coelho, Mara C S; Mendes, Eduardo M A M; Aguirre, Luis A

    2008-06-01

    A determinism test is proposed based on the well-known method of the surrogate data. Assuming predictability to be a signature of determinism, the proposed method checks for intracycle (e.g., short-term) determinism in the pseudoperiodic time series for which standard methods of surrogate analysis do not apply. The approach presented is composed of two steps. First, the data are preprocessed to reduce the effects of seasonal and trend components. Second, standard tests of surrogate analysis can then be used. The determinism test is applied to simulated and experimental pseudoperiodic time series and the results show the applicability of the proposed test.

  16. Real-Time Optimization for Economic Model Predictive Control

    DEFF Research Database (Denmark)

    Sokoler, Leo Emil; Edlund, Kristian; Frison, Gianluca

    2012-01-01

    In this paper, we develop an efficient homogeneous and self-dual interior-point method for the linear programs arising in economic model predictive control. To exploit structure in the optimization problems, the algorithm employs a highly specialized Riccati iteration procedure. Simulations show...

  17. Optimization and determination of polycyclic aromatic hydrocarbons in biochar-based fertilizers.

    Science.gov (United States)

    Chen, Ping; Zhou, Hui; Gan, Jay; Sun, Mingxing; Shang, Guofeng; Liu, Liang; Shen, Guoqing

    2015-03-01

    The agronomic benefit of biochar has attracted widespread attention to biochar-based fertilizers. However, the inevitable presence of polycyclic aromatic hydrocarbons in biochar is a matter of concern because of the health and ecological risks of these compounds. The strong adsorption of polycyclic aromatic hydrocarbons to biochar complicates their analysis and extraction from biochar-based fertilizers. In this study, we optimized and validated a method for determining the 16 priority polycyclic aromatic hydrocarbons in biochar-based fertilizers. Results showed that accelerated solvent extraction exhibited high extraction efficiency. Based on a Box-Behnken design with a triplicate central point, accelerated solvent extraction was used under the following optimal operational conditions: extraction temperature of 78°C, extraction time of 17 min, and two static cycles. The optimized method was validated by assessing the linearity of analysis, limit of detection, limit of quantification, recovery, and application to real samples. The results showed that the 16 polycyclic aromatic hydrocarbons exhibited good linearity, with a correlation coefficient of 0.996. The limits of detection varied between 0.001 (phenanthrene) and 0.021 mg/g (benzo[ghi]perylene), and the limits of quantification varied between 0.004 (phenanthrene) and 0.069 mg/g (benzo[ghi]perylene). The relative recoveries of the 16 polycyclic aromatic hydrocarbons were 70.26-102.99%. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. The determinants of part-time work in Metropolitan Lima

    Directory of Open Access Journals (Sweden)

    Manuel Enrique Saavedra Martinez

    2011-12-01

    Full Text Available The following paper examines the part-time work in Metropolitan Lima in 2008. The overall objective is to identify the determinants of the incidence of part-time work in Lima. We worked with one Probit econometric model, measured by the National Survey of Households (NSH, which explores the job characteristics of people. This will determine the presence of part-time workers in the areas of trade, health, education and communication; also realized that this group has completed university studies and incomplete, and the woman has a probability of 83,11397% more than men of working part time.

  19. On the Determinants of Optimal Border Taxes for a Small Open Economy

    DEFF Research Database (Denmark)

    Munk, Knud Jørgen; Rasmussen, Bo Sandemann

    of the primary factor and domestic consumption of the export good cannot be taxed is nevertheless a constraint; this insight provides the key to understanding what determines the optimal tariff structure. The optimal border tax structure is derived for both exogenous and endogenous labour supply, and the results...... are interpreted in the spirit of the Corlett-Hague results for the optimal tax structure in a closed economy and compared with results from CGE models....

  20. Turnpike theory of continuous-time linear optimal control problems

    CERN Document Server

    Zaslavski, Alexander J

    2015-01-01

    Individual turnpike results are of great interest due to their numerous applications in engineering and in economic theory; in this book the study is focused on new results of turnpike phenomenon in linear optimal control problems.  The book is intended for engineers as well as for mathematicians interested in the calculus of variations, optimal control, and in applied functional analysis. Two large classes of problems are studied in more depth. The first class studied in Chapter 2 consists of linear control problems with periodic nonsmooth convex integrands. Chapters 3-5 consist of linear control problems with autonomous nonconvex and nonsmooth integrands.  Chapter 6 discusses a turnpike property for dynamic zero-sum games with linear constraints. Chapter 7 examines genericity results. In Chapter 8, the description of structure of variational problems with extended-valued integrands is obtained. Chapter 9 ends the exposition with a study of turnpike phenomenon for dynamic games with extended value integran...

  1. Optimization of cutting parameters for machining time in turning process

    Science.gov (United States)

    Mavliutov, A. R.; Zlotnikov, E. G.

    2018-03-01

    This paper describes the most effective methods for nonlinear constraint optimization of cutting parameters in the turning process. Among them are Linearization Programming Method with Dual-Simplex algorithm, Interior Point method, and Augmented Lagrangian Genetic Algorithm (ALGA). Every each of them is tested on an actual example – the minimization of production rate in turning process. The computation was conducted in the MATLAB environment. The comparative results obtained from the application of these methods show: The optimal value of the linearized objective and the original function are the same. ALGA gives sufficiently accurate values, however, when the algorithm uses the Hybrid function with Interior Point algorithm, the resulted values have the maximal accuracy.

  2. Optimal Retention Level for Infinite Time Horizons under MADM

    Directory of Open Access Journals (Sweden)

    Başak Bulut Karageyik

    2016-12-01

    Full Text Available In this paper, we approximate the aggregate claims process by using the translated gamma process under the classical risk model assumptions, and we investigate the ultimate ruin probability. We consider optimal reinsurance under the minimum ultimate ruin probability, as well as the maximum benefit criteria: released capital, expected profit and exponential-fractional-logarithmic utility from the insurer’s point of view. Numerical examples are presented to explain how the optimal initial surplus and retention level are changed according to the individual claim amounts, loading factors and weights of the criteria. In the decision making process, we use The Analytical Hierarchy Process (AHP and The Technique for Order of Preference by Similarity to ideal Solution (TOPSIS methods as the Multi-Attribute Decision Making methods (MADM and compare our results considering different combinations of loading factors for both exponential and Pareto individual claims.

  3. Performance deterioration modeling and optimal preventive maintenance strategy under scheduled servicing subject to mission time

    Directory of Open Access Journals (Sweden)

    Li Dawei

    2014-08-01

    Full Text Available Servicing is applied periodically in practice with the aim of restoring the system state and prolonging the lifetime. It is generally seen as an imperfect maintenance action which has a chief influence on the maintenance strategy. In order to model the maintenance effect of servicing, this study analyzes the deterioration characteristics of system under scheduled servicing. And then the deterioration model is established from the failure mechanism by compound Poisson process. On the basis of the system damage value and failure mechanism, the failure rate refresh factor is proposed to describe the maintenance effect of servicing. A maintenance strategy is developed which combines the benefits of scheduled servicing and preventive maintenance. Then the optimization model is given to determine the optimal servicing period and preventive maintenance time, with an objective to minimize the system expected life-cycle cost per unit time and a constraint on system survival probability for the duration of mission time. Subject to mission time, it can control the ability of accomplishing the mission at any time so as to ensure the high dependability. An example of water pump rotor relating to scheduled servicing is introduced to illustrate the failure rate refresh factor and the proposed maintenance strategy. Compared with traditional methods, the numerical results show that the failure rate refresh factor can describe the maintenance effect of servicing more intuitively and objectively. It also demonstrates that this maintenance strategy can prolong the lifetime, reduce the total lifetime maintenance cost and guarantee the dependability of system.

  4. Optimal Entry Timing in Markets with Social Influence

    OpenAIRE

    Yogesh V. Joshi; David J. Reibstein; Z. John Zhang

    2009-01-01

    Firms routinely face the challenging decision of whether to enter a new market where a firm's strong presence in an existing market has a positive influence (the leverage effect) on product adoption in the new market, but the reciprocal social influence on the existing market is negative (the backlash effect). In this paper, we show that a firm's optimal entry strategy in this situation cannot be characterized by the familiar "now or never" or "now or at maturity" strategies proposed in the l...

  5. Allowed outage time for test and maintenance - Optimization of safety

    International Nuclear Information System (INIS)

    Cepin, M.; Mavko, B.

    1997-01-01

    The main objective of the project is the development and application of methodologies for improvement and optimization of test and maintenance activities for safety related equipment in NPPs on basis of their enhanced safety. The probabilistic safety assessment serves as a base, which does not mean the replacement of the deterministic analyses but the consideration of probabilistic safety assessment results as complement to deterministic results. 15 refs, 2 figs

  6. Peeling Potatoes Near-optimally in Near-linear Time

    Czech Academy of Sciences Publication Activity Database

    Cabello, S.; Cibulka, J.; Kynčl, J.; Saumell, Maria; Valtr, P.

    2017-01-01

    Roč. 46, č. 5 (2017), s. 1574-1602 ISSN 0097-5397 R&D Projects: GA ČR GBP202/12/G061 Grant - others:GA MŠk(CZ) LO1506; GA MŠk(CZ) EE2.3.30.0038 Institutional support: RVO:67985807 Keywords : geometric optimization * potato peeling * visibility graph * geometric probability * approximation algorithm Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.433, year: 2016

  7. Beeping a Deterministic Time-Optimal Leader Election

    OpenAIRE

    Dufoulon , Fabien; Burman , Janna; Beauquier , Joffroy

    2018-01-01

    The beeping model is an extremely restrictive broadcast communication model that relies only on carrier sensing. In this model, we solve the leader election problem with an asymptotically optimal round complexity of O(D + log n), for a network of unknown size n and unknown diameter D (but with unique identifiers). Contrary to the best previously known algorithms in the same setting, the proposed one is deterministic. The techniques we introduce give a new insight as to how local constraints o...

  8. The implication of missing the optimal-exercise time of an American option

    NARCIS (Netherlands)

    Chockalingam, A.; Feng, H.

    2015-01-01

    The optimal-exercise policy of an American option dictates when the option should be exercised. In this paper, we consider the implications of missing the optimal exercise time of an American option. For the put option, this means holding the option until it is deeper in-the-money when the optimal

  9. Sampled-data and discrete-time H2 optimal control

    NARCIS (Netherlands)

    Trentelman, Harry L.; Stoorvogel, Anton A.

    1993-01-01

    This paper deals with the sampled-data H2 optimal control problem. Given a linear time-invariant continuous-time system, the problem of minimizing the H2 performance over all sampled-data controllers with a fixed sampling period can be reduced to a pure discrete-time H2 optimal control problem. This

  10. Real-Time Optimization and Control of Next-Generation Distribution

    Science.gov (United States)

    -Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution developing a system-theoretic distribution network management framework that unifies real-time voltage and Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next

  11. Extraction optimization and UHPLC method development for determination of the 20-hydroxyecdysone in Sida tuberculata leaves.

    Science.gov (United States)

    da Rosa, Hemerson S; Koetz, Mariana; Santos, Marí Castro; Jandrey, Elisa Helena Farias; Folmer, Vanderlei; Henriques, Amélia Teresinha; Mendez, Andreas Sebastian Loureiro

    2018-04-01

    Sida tuberculata (ST) is a Malvaceae species widely distributed in Southern Brazil. In traditional medicine, ST has been employed as hypoglycemic, hypocholesterolemic, anti-inflammatory and antimicrobial. Additionally, this species is chemically characterized by flavonoids, alkaloids and phytoecdysteroids mainly. The present work aimed to optimize the extractive technique and to validate an UHPLC method for the determination of 20-hydroxyecdsone (20HE) in the ST leaves. Box-Behnken Design (BBD) was used in method optimization. The extractive methods tested were: static and dynamic maceration, ultrasound, ultra-turrax and reflux. In the Box-Behnken three parameters were evaluated in three levels (-1, 0, +1), particle size, time and plant:solvent ratio. In validation method, the parameters of selectivity, specificity, linearity, limits of detection and quantification (LOD, LOQ), precision, accuracy and robustness were evaluated. The results indicate static maceration as better technique to obtain 20HE peak area in ST extract. The optimal extraction from surface response methodology was achieved with the parameters granulometry of 710 nm, 9 days of maceration and plant:solvent ratio 1:54 (w/v). The UHPLC-PDA analytical developed method showed full viability of performance, proving to be selective, linear, precise, accurate and robust for 20HE detection in ST leaves. The average content of 20HE was 0.56% per dry extract. Thus, the optimization of extractive method in ST leaves increased the concentration of 20HE in crude extract, and a reliable method was successfully developed according to validation requirements and in agreement with current legislation. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. Determination of the optimal number of components in independent components analysis.

    Science.gov (United States)

    Kassouf, Amine; Jouan-Rimbaud Bouveresse, Delphine; Rutledge, Douglas N

    2018-03-01

    Independent components analysis (ICA) may be considered as one of the most established blind source separation techniques for the treatment of complex data sets in analytical chemistry. Like other similar methods, the determination of the optimal number of latent variables, in this case, independent components (ICs), is a crucial step before any modeling. Therefore, validation methods are required in order to decide about the optimal number of ICs to be used in the computation of the final model. In this paper, three new validation methods are formally presented. The first one, called Random_ICA, is a generalization of the ICA_by_blocks method. Its specificity resides in the random way of splitting the initial data matrix into two blocks, and then repeating this procedure several times, giving a broader perspective for the selection of the optimal number of ICs. The second method, called KMO_ICA_Residuals is based on the computation of the Kaiser-Meyer-Olkin (KMO) index of the transposed residual matrices obtained after progressive extraction of ICs. The third method, called ICA_corr_y, helps to select the optimal number of ICs by computing the correlations between calculated proportions and known physico-chemical information about samples, generally concentrations, or between a source signal known to be present in the mixture and the signals extracted by ICA. These three methods were tested using varied simulated and experimental data sets and compared, when necessary, to ICA_by_blocks. Results were relevant and in line with expected ones, proving the reliability of the three proposed methods. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Optimal Timing of Heart Transplant After HeartMate II Left Ventricular Assist Device Implantation.

    Science.gov (United States)

    Steffen, Robert J; Blackstone, Eugene H; Smedira, Nicholas G; Soltesz, Edward G; Hoercher, Katherine J; Thuita, Lucy; Starling, Randall C; Mountis, Maria; Moazami, Nader

    2017-11-01

    Optimal timing of heart transplantation in patients supported with second-generation left ventricular assist devices (LVADs) is unknown. Despite this, patients with LVADs continue to receive priority on the heart transplant waiting list. Our objective was to determine the optimal timing of transplantation for patients bridged with continuous-flow LVADs. A total of 301 HeartMate II LVADs (Thoratec Corp, Pleasanton, CA) were implanted in 285 patients from October 2004 to June 2013, and 86 patients underwent transplantation through the end of follow-up. Optimal transplantation timing was the product of surviving on LVAD support and surviving transplant. Three-year survival after both HeartMate II implantation and heart transplantation was unchanged when transplantation occurred within 9 months of implantation. Survival decreased as the duration of support exceeded this. Preoperative risk factors for death on HeartMate II support were prior valve operation, prior coronary artery bypass grafting, low albumin, low glomerular filtration rate, higher mean arterial pressure, hypertension, and earlier date of implant. Survival for patients without these risk factors was lowest when transplant was performed within 3 months but was relatively constant with increased duration of support. Longer duration of support was associated with poorer survival for patients with many of these risk factors. Device reimplantation, intracranial hemorrhage, and postimplant dialysis during HeartMate II support were associated with decreased survival. Survival of patients supported by the HeartMate II is affected by preoperative comorbidities and postoperative complications. Transplantation before complications is imperative in optimizing survival. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  14. Efficient Round-Trip Time Optimization for Replica-Exchange Enveloping Distribution Sampling (RE-EDS).

    Science.gov (United States)

    Sidler, Dominik; Cristòfol-Clough, Michael; Riniker, Sereina

    2017-06-13

    Replica-exchange enveloping distribution sampling (RE-EDS) allows the efficient estimation of free-energy differences between multiple end-states from a single molecular dynamics (MD) simulation. In EDS, a reference state is sampled, which can be tuned by two types of parameters, i.e., smoothness parameters(s) and energy offsets, such that all end-states are sufficiently sampled. However, the choice of these parameters is not trivial. Replica exchange (RE) or parallel tempering is a widely applied technique to enhance sampling. By combining EDS with the RE technique, the parameter choice problem could be simplified and the challenge shifted toward an optimal distribution of the replicas in the smoothness-parameter space. The choice of a certain replica distribution can alter the sampling efficiency significantly. In this work, global round-trip time optimization (GRTO) algorithms are tested for the use in RE-EDS simulations. In addition, a local round-trip time optimization (LRTO) algorithm is proposed for systems with slowly adapting environments, where a reliable estimate for the round-trip time is challenging to obtain. The optimization algorithms were applied to RE-EDS simulations of a system of nine small-molecule inhibitors of phenylethanolamine N-methyltransferase (PNMT). The energy offsets were determined using our recently proposed parallel energy-offset (PEOE) estimation scheme. While the multistate GRTO algorithm yielded the best replica distribution for the ligands in water, the multistate LRTO algorithm was found to be the method of choice for the ligands in complex with PNMT. With this, the 36 alchemical free-energy differences between the nine ligands were calculated successfully from a single RE-EDS simulation 10 ns in length. Thus, RE-EDS presents an efficient method for the estimation of relative binding free energies.

  15. Distributed Optimization Design of Continuous-Time Multiagent Systems With Unknown-Frequency Disturbances.

    Science.gov (United States)

    Wang, Xinghu; Hong, Yiguang; Yi, Peng; Ji, Haibo; Kang, Yu

    2017-05-24

    In this paper, a distributed optimization problem is studied for continuous-time multiagent systems with unknown-frequency disturbances. A distributed gradient-based control is proposed for the agents to achieve the optimal consensus with estimating unknown frequencies and rejecting the bounded disturbance in the semi-global sense. Based on convex optimization analysis and adaptive internal model approach, the exact optimization solution can be obtained for the multiagent system disturbed by exogenous disturbances with uncertain parameters.

  16. Variable-Field Analytical Ultracentrifugation: I. Time-Optimized Sedimentation Equilibrium

    Science.gov (United States)

    Ma, Jia; Metrick, Michael; Ghirlando, Rodolfo; Zhao, Huaying; Schuck, Peter

    2015-01-01

    Sedimentation equilibrium (SE) analytical ultracentrifugation (AUC) is a gold standard for the rigorous determination of macromolecular buoyant molar masses and the thermodynamic study of reversible interactions in solution. A significant experimental drawback is the long time required to attain SE, which is usually on the order of days. We have developed a method for time-optimized SE (toSE) with defined time-varying centrifugal fields that allow SE to be attained in a significantly (up to 10-fold) shorter time than is usually required. To achieve this, numerical Lamm equation solutions for sedimentation in time-varying fields are computed based on initial estimates of macromolecular transport properties. A parameterized rotor-speed schedule is optimized with the goal of achieving a minimal time to equilibrium while limiting transient sample preconcentration at the base of the solution column. The resulting rotor-speed schedule may include multiple over- and underspeeding phases, balancing the formation of gradients from strong sedimentation fluxes with periods of high diffusional transport. The computation is carried out in a new software program called TOSE, which also facilitates convenient experimental implementation. Further, we extend AUC data analysis to sedimentation processes in such time-varying centrifugal fields. Due to the initially high centrifugal fields in toSE and the resulting strong migration, it is possible to extract sedimentation coefficient distributions from the early data. This can provide better estimates of the size of macromolecular complexes and report on sample homogeneity early on, which may be used to further refine the prediction of the rotor-speed schedule. In this manner, the toSE experiment can be adapted in real time to the system under study, maximizing both the information content and the time efficiency of SE experiments. PMID:26287634

  17. Privacy, Time Consistent Optimal Labour Income Taxation and Education Policy

    OpenAIRE

    Konrad, Kai A.

    1999-01-01

    Incomplete information is a commitment device for time consistency problems. In the context of time consistent labour income taxation privacy reduces welfare losses and increases the effectiveness of public education as a second best policy.

  18. Free terminal time optimal control problem of an HIV model based on a conjugate gradient method.

    Science.gov (United States)

    Jang, Taesoo; Kwon, Hee-Dae; Lee, Jeehyun

    2011-10-01

    The minimum duration of treatment periods and the optimal multidrug therapy for human immunodeficiency virus (HIV) type 1 infection are considered. We formulate an optimal tracking problem, attempting to drive the states of the model to a "healthy" steady state in which the viral load is low and the immune response is strong. We study an optimal time frame as well as HIV therapeutic strategies by analyzing the free terminal time optimal tracking control problem. The minimum duration of treatment periods and the optimal multidrug therapy are found by solving the corresponding optimality systems with the additional transversality condition for the terminal time. We demonstrate by numerical simulations that the optimal dynamic multidrug therapy can lead to the long-term control of HIV by the strong immune response after discontinuation of therapy.

  19. Determination of an Optimal Control Strategy for a Generic Surface Vehicle

    Science.gov (United States)

    2014-06-18

    TERMS Autonomous Vehicles Boundary Value Problem Dynamic Programming Surface Vehicles Optimal Control Path Planning 16...to follow prescribed motion trajectories. In particular, for autonomous vehicles , this motion trajectory is given by the determination of the

  20. Optimization of time and location dependent spent nuclear fuel storage capacity

    International Nuclear Information System (INIS)

    Macek, V.

    1977-01-01

    A linear spent fuel storage model is developed to identify cost-effective spent nuclear fuel storage strategies. The purpose of this model is to provide guidelines for the implementation of the optimal time-dependent spent fuel storage capacity expansion in view of the current economic and regulatory environment which has resulted in phase-out of the closed nuclear fuel cycle. Management alternatives of the spent fuel storage backlog, which is created by mismatch between spent fuel generation rate and spent fuel disposition capability, are represented by aggregate decision variables which describe the time dependent on-reactor-site and off-site spent fuel storage capacity additions, and the amount of spent fuel transferred to off-site storage facilities. Principal constraints of the model assure determination of cost optimal spent fuel storage expansion strategies, while spent fuel storage requirements are met at all times. A detailed physical and economic analysis of the essential components of the spent fuel storage problem, which precedes the model development, assures its realism. The effects of technological limitations on the on-site spent fuel storage expansion and timing of reinitiation of the spent fuel reprocessing on optimal spent fuel storage capacity expansion are investigated. The principal results of the study indicate that (a) expansion of storage capacity beyond that of currently planned facilities is necessary, and (b) economics of the post-reactor fuel cycle is extremely sensitive to the timing of reinitiation of spent fuel reprocessing. Postponement of reprocessing beyond mid-1982 may result in net negative economic liability of the back end of the nuclear fuel cycle

  1. Temporal variation of optimal UV exposure time over Korea: risks and benefits of surface UV radiation

    Science.gov (United States)

    Lee, Y. G.; Koo, J. H.

    2015-12-01

    Solar UV radiation in a wavelength range between 280 to 400 nm has both positive and negative influences on human body. Surface UV radiation is the main natural source of vitamin D, providing the promotion of bone and musculoskeletal health and reducing the risk of a number of cancers and other medical conditions. However, overexposure to surface UV radiation is significantly related with the majority of skin cancer, in addition other negative health effects such as sunburn, skin aging, and some forms of eye cataracts. Therefore, it is important to estimate the optimal UV exposure time, representing a balance between reducing negative health effects and maximizing sufficient vitamin D production. Previous studies calculated erythemal UV and vitamin-D UV from the measured and modelled spectral irradiances, respectively, by weighting CIE Erythema and Vitamin D3 generation functions (Kazantzidis et al., 2009; Fioletov et al., 2010). In particular, McKenzie et al. (2009) suggested the algorithm to estimate vitamin-D production UV from erythemal UV (or UV index) and determined the optimum conditions of UV exposure based on skin type Ⅱ according to the Fitzpatrick (1988). Recently, there are various demands for risks and benefits of surface UV radiation on public health over Korea, thus it is necessary to estimate optimal UV exposure time suitable to skin type of East Asians. This study examined the relationship between erythemally weighted UV (UVEry) and vitamin D weighted UV (UVVitD) over Korea during 2004-2012. The temporal variations of the ratio (UVVitD/UVEry) were also analyzed and the ratio as a function of UV index was applied in estimating the optimal UV exposure time. In summer with high surface UV radiation, short exposure time leaded to sufficient vitamin D and erythema and vice versa in winter. Thus, the balancing time in winter was enough to maximize UV benefits and minimize UV risks.

  2. Optimal time travel in the Gödel universe

    Science.gov (United States)

    Natário, José

    2012-04-01

    Using the theory of optimal rocket trajectories in general relativity, recently developed in Henriques and Natário (2011), we present a candidate for the minimum total integrated acceleration closed timelike curve in the Gödel universe, and give evidence for its minimality. The total integrated acceleration of this curve is lower than Malament's conjectured value (Malament 1984), as was already implicit in the work of Manchak (Gen. Relativ. Gravit. 51-60, 2011); however, Malament's conjecture does seem to hold for periodic closed timelike curves.

  3. Optimizing Travel Time to Outpatient Interventional Radiology Procedures in a Multi-Site Hospital System Using a Google Maps Application.

    Science.gov (United States)

    Mandel, Jacob E; Morel-Ovalle, Louis; Boas, Franz E; Ziv, Etay; Yarmohammadi, Hooman; Deipolyi, Amy; Mohabir, Heeralall R; Erinjeri, Joseph P

    2018-02-20

    The purpose of this study is to determine whether a custom Google Maps application can optimize site selection when scheduling outpatient interventional radiology (IR) procedures within a multi-site hospital system. The Google Maps for Business Application Programming Interface (API) was used to develop an internal web application that uses real-time traffic data to determine estimated travel time (ETT; minutes) and estimated travel distance (ETD; miles) from a patient's home to each a nearby IR facility in our hospital system. Hypothetical patient home addresses based on the 33 cities comprising our institution's catchment area were used to determine the optimal IR site for hypothetical patients traveling from each city based on real-time traffic conditions. For 10/33 (30%) cities, there was discordance between the optimal IR site based on ETT and the optimal IR site based on ETD at non-rush hour time or rush hour time. By choosing to travel to an IR site based on ETT rather than ETD, patients from discordant cities were predicted to save an average of 7.29 min during non-rush hour (p = 0.03), and 28.80 min during rush hour (p travel time when more than one location providing IR procedures is available within the same hospital system.

  4. Geometry and Topology Optimization of Statically Determinate Beams under Fixed and Most Unfavorably Distributed Load

    Directory of Open Access Journals (Sweden)

    Agata Kozikowska

    Full Text Available Abstract The paper concerns topology and geometry optimization of statically determinate beams with an arbitrary number of pin supports. The beams are simultaneously exposed to uniform dead load and arbitrarily distributed live load and optimized for the absolute maximum bending moment. First, all the beams with fixed topology are subjected to geometrical optimization by genetic algorithm. Strict mathematical formulas for calculation of optimal geometrical parameters are found for all topologies and any ratio of dead to live load. Then beams with the same minimal values of the objective function and different topologies are classified into groups called topological classes. The detailed characteristics of these classes are described.

  5. A Comprehensive Optimization Strategy for Real-time Spatial Feature Sharing and Visual Analytics in Cyberinfrastructure

    Science.gov (United States)

    Li, W.; Shao, H.

    2017-12-01

    For geospatial cyberinfrastructure enabled web services, the ability of rapidly transmitting and sharing spatial data over the Internet plays a critical role to meet the demands of real-time change detection, response and decision-making. Especially for the vector datasets which serve as irreplaceable and concrete material in data-driven geospatial applications, their rich geometry and property information facilitates the development of interactive, efficient and intelligent data analysis and visualization applications. However, the big-data issues of vector datasets have hindered their wide adoption in web services. In this research, we propose a comprehensive optimization strategy to enhance the performance of vector data transmitting and processing. This strategy combines: 1) pre- and on-the-fly generalization, which automatically determines proper simplification level through the introduction of appropriate distance tolerance (ADT) to meet various visualization requirements, and at the same time speed up simplification efficiency; 2) a progressive attribute transmission method to reduce data size and therefore the service response time; 3) compressed data transmission and dynamic adoption of a compression method to maximize the service efficiency under different computing and network environments. A cyberinfrastructure web portal was developed for implementing the proposed technologies. After applying our optimization strategies, substantial performance enhancement is achieved. We expect this work to widen the use of web service providing vector data to support real-time spatial feature sharing, visual analytics and decision-making.

  6. Determination of Optimal Double Sampling Plan using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Sampath Sundaram

    2012-03-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Designing double sampling plan requires identification of sample sizes and acceptance numbers. In this paper a genetic algorithm has been designed for the selection of optimal acceptance numbers and sample sizes for the specified producer’s risk and consumer’s risk. Implementation of the algorithm has been illustrated numerically for different choices of quantities involved in a double sampling plan   

  1. Access time optimization of SRAM memory with statistical yield constraint

    NARCIS (Netherlands)

    Doorn, T.S.; Maten, ter E.J.W.; Di Bucchianico, A.; Beelen, T.G.J.; Janssen, H.H.J.M.

    2012-01-01

    A product may fail when design parameters are subject to large deviations. To guarantee yield one likes to determine bounds on the parameter range such that the fail probability P_fail is small. For Static Random Access Memory (SRAM) characteristics like Static Noise Margin and Read Current,

  2. Design Optimization of Mixed-Criticality Real-Time Embedded Systems

    DEFF Research Database (Denmark)

    Tamas-Selicean, Domitian; Pop, Paul

    2015-01-01

    is allocated several time slots on a processor. Tasks of different SILs can share a partition only if they are all elevated to the highest SIL among them. Such elevation leads to increased development costs, which increase dramatically with each SIL. Tasks of higher SILs can be decomposed into redundant...... structures of lower SIL tasks. We are interested to determine (i) the mapping of tasks to processors, (ii) the assignment of tasks to partitions, (iii) the decomposition of tasks into redundant lower SIL tasks, (iv) the sequence and size of the partition time slots on each processor, and (v) the schedule...... tables, such that all the applications are schedulable and the development costs are minimized. We have proposed a Tabu Search-based approach to solve this optimization problem. The proposed algorithm has been evaluated using several synthetic and real-life benchmarks....

  3. Estimation of time-varying reactivity by the H∞ optimal linear filter

    International Nuclear Information System (INIS)

    Suzuki, Katsuo; Shimazaki, Junya; Watanabe, Koiti

    1995-01-01

    The problem of estimating the time-varying net reactivity from flux measurements is solved for a point reactor kinetics model using a linear filtering technique in an H ∞ settings. In order to sue this technique, an appropriate dynamical model of the reactivity is constructed that can be embedded into the reactor model as one of its variables. A filter, which minimizes the H ∞ norm of the estimation error power spectrum, operates on neutron density measurements corrupted by noise and provides an estimate of the dynamic net reactivity. Computer simulations are performed to reveal the basic characteristics of the H ∞ optimal filter. The results of the simulation indicate that the filter can be used to determine the time-varying reactivity from neutron density measurements that have been corrupted by noise

  4. Multi-objective optimization model of CNC machining to minimize processing time and environmental impact

    Science.gov (United States)

    Hamada, Aulia; Rosyidi, Cucuk Nur; Jauhari, Wakhid Ahmad

    2017-11-01

    Minimizing processing time in a production system can increase the efficiency of a manufacturing company. Processing time are influenced by application of modern technology and machining parameter. Application of modern technology can be apply by use of CNC machining, one of the machining process can be done with a CNC machining is turning. However, the machining parameters not only affect the processing time but also affect the environmental impact. Hence, optimization model is needed to optimize the machining parameters to minimize the processing time and environmental impact. This research developed a multi-objective optimization to minimize the processing time and environmental impact in CNC turning process which will result in optimal decision variables of cutting speed and feed rate. Environmental impact is converted from environmental burden through the use of eco-indicator 99. The model were solved by using OptQuest optimization software from Oracle Crystal Ball.

  5. Application of Minimum-time Optimal Control System in Buck-Boost Bi-linear Converters

    Directory of Open Access Journals (Sweden)

    S. M. M. Shariatmadar

    2017-08-01

    Full Text Available In this study, the theory of minimum-time optimal control system in buck-boost bi-linear converters is described, so that output voltage regulation is carried out within minimum time. For this purpose, the Pontryagin's Minimum Principle is applied to find optimal switching level applying minimum-time optimal control rules. The results revealed that by utilizing an optimal switching level instead of classical switching patterns, output voltage regulation will be carried out within minimum time. However, transient energy index of increased overvoltage significantly reduces in order to attain minimum time optimal control in reduced output load. The laboratory results were used in order to verify numerical simulations.

  6. Determination of beta attenuation coefficients by means of timing method

    International Nuclear Information System (INIS)

    Ermis, E.E.; Celiktas, C.

    2012-01-01

    Highlights: ► Beta attenuation coefficients of absorber materials were found in this study. ► For this process, a new method (timing method) was suggested. ► The obtained beta attenuation coefficients were compatible with the results from the traditional one. ► The timing method can be used to determine beta attenuation coefficient. - Abstract: Using a counting system with plastic scintillation detector, beta linear and mass attenuation coefficients were determined for bakelite, Al, Fe and plexiglass absorbers by means of timing method. To show the accuracy and reliability of the obtained results through this method, the coefficients were also found via conventional energy method. Obtained beta attenuation coefficients from both methods were compared with each other and the literature values. Beta attenuation coefficients obtained through timing method were found to be compatible with the values obtained from conventional energy method and the literature.

  7. Determination of optimal diagnostic criteria for purulent vaginal discharge and cytological endometritis in dairy cows.

    Science.gov (United States)

    Denis-Robichaud, J; Dubuc, J

    2015-10-01

    The objectives of this observational study were to identify the optimal diagnostic criteria for purulent vaginal discharge (PVD) and cytological endometritis (ENDO) using vaginal discharge, endometrial cytology, and leukocyte esterase (LE) tests, and to quantify their effect on subsequent reproductive performance. Data generated from 1,099 untreated Holstein cows (28 herds) enrolled in a randomized clinical trial were used in this study. Cows were examined at 35 (± 7) d in milk for PVD using vaginal discharge scoring and for ENDO using endometrial cytology and LE testing. Optimal combinations of diagnostic criteria were determined based on the lowest Akaike information criterion (AIC) to predict pregnancy status at first service. Once identified, these criteria were used to quantify the effect of PVD and ENDO on pregnancy risk at first service and on pregnancy hazard until 200 d in milk (survival analysis). Predicting ability of these diagnostic criteria was determined using area under the curve (AUC) values. The prevalence of PVD and ENDO was calculated as well as the agreement between endometrial cytology and LE. The optimal diagnostic criteria (lowest AIC) identified in this study were purulent vaginal discharge or worse (≥ 4), ≥ 6% polymorphonuclear leukocytes (PMNL) by endometrial cytology, and small amounts of leukocytes or worse (≥ 1) by LE testing. When using the combination of vaginal discharge and PMNL percentage as diagnostic tools (n = 1,099), the prevalences of PVD and ENDO were 17.1 and 36.2%, respectively. When using the combination of vaginal discharge and LE (n = 915), the prevalences of PVD and ENDO were 17.1 and 48.4%. The optimal strategies for predicting pregnancy status at first service were the use of LE only (AUC = 0.578) and PMNL percentage only (AUC = 0.575). Cows affected by PVD and ENDO had 0.36 and 0.32 times the odds, respectively, of being pregnant at first service when using PMNL percentage compared with that of unaffected

  8. Robust Optimization for Time-Cost Tradeoff Problem in Construction Projects

    OpenAIRE

    Li, Ming; Wu, Guangdong

    2014-01-01

    Construction projects are generally subject to uncertainty, which influences the realization of time-cost tradeoff in project management. This paper addresses a time-cost tradeoff problem under uncertainty, in which activities in projects can be executed in different construction modes corresponding to specified time and cost with interval uncertainty. Based on multiobjective robust optimization method, a robust optimization model for time-cost tradeoff problem is developed. In order to illus...

  9. Determining optimal preventive maintenance interval for component of Well Barrier Element in an Oil & Gas Company

    Science.gov (United States)

    Siswanto, A.; Kurniati, N.

    2018-04-01

    An oil and gas company has 2,268 oil and gas wells. Well Barrier Element (WBE) is installed in a well to protect human, prevent asset damage and minimize harm to the environment. The primary WBE component is Surface Controlled Subsurface Safety Valve (SCSSV). The secondary WBE component is Christmas Tree Valves that consist of four valves i.e. Lower Master Valve (LMV), Upper Master Valve (UMV), Swab Valve (SV) and Wing Valve (WV). Current practice on WBE Preventive Maintenance (PM) program is conducted by considering the suggested schedule as stated on manual. Corrective Maintenance (CM) program is conducted when the component fails unexpectedly. Both PM and CM need cost and may cause production loss. This paper attempts to analyze the failure data and reliability based on historical data. Optimal PM interval is determined in order to minimize the total cost of maintenance per unit time. The optimal PM interval for SCSSV is 730 days, LMV is 985 days, UMV is 910 days, SV is 900 days and WV is 780 days. In average of all components, the cost reduction by implementing the suggested interval is 52%, while the reliability is improved by 4% and the availability is increased by 5%.

  10. Determining the optimal number of independent components for reproducible transcriptomic data analysis.

    Science.gov (United States)

    Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei

    2017-09-11

    Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the number of components (factors) to compute. The optimal choice of this parameter, related to determining the effective data dimension, remains an open question in the application of blind source separation techniques to transcriptomic data. Here we address the question of optimizing the number of statistically independent components in the analysis of transcriptomic data for reproducibility of the components in multiple runs of ICA (within the same or within varying effective dimensions) and in multiple independent datasets. To this end, we introduce ranking of independent components based on their stability in multiple ICA computation runs and define a distinguished number of components (Most Stable Transcriptome Dimension, MSTD) corresponding to the point of the qualitative change of the stability profile. Based on a large body of data, we demonstrate that a sufficient number of dimensions is required for biological interpretability of the ICA decomposition and that the most stable components with ranks below MSTD have more chances to be reproduced in independent studies compared to the less stable ones. At the same time, we show that a transcriptomics dataset can be reduced to a relatively high number of dimensions without losing the interpretability of ICA, even though higher dimensions give rise to components driven by small gene sets. We suggest a protocol of ICA application to transcriptomics data with a possibility of prioritizing components with respect to their reproducibility that strengthens the biological interpretation. Computing too few components (much less than MSTD) is not optimal for interpretability of the results. The components ranked within MSTD range have more chances to be reproduced in independent studies.

  11. Discrete Analysis of Portfolio Selection with Optimal Stopping Time

    Directory of Open Access Journals (Sweden)

    Jianfeng Liang

    2009-01-01

    Full Text Available Most of the investments in practice are carried out without certain horizons. There are many factors to drive investment to a stop. In this paper, we consider a portfolio selection policy with market-related stopping time. Particularly, we assume that the investor exits the market once his wealth reaches a given investment target or falls below a bankruptcy threshold. Our objective is to minimize the expected time when the investment target is obtained, at the same time, we guarantee the probability that bankruptcy happens is no larger than a given level. We formulate the problem as a mix integer linear programming model and make analysis of the model by using a numerical example.

  12. A Harmony Search Algorithm approach for optimizing traffic signal timings

    Directory of Open Access Journals (Sweden)

    Mauro Dell'Orco

    2013-07-01

    Full Text Available In this study, a bi-level formulation is presented for solving the Equilibrium Network Design Problem (ENDP. The optimisation of the signal timing has been carried out at the upper-level using the Harmony Search Algorithm (HSA, whilst the traffic assignment has been carried out through the Path Flow Estimator (PFE at the lower level. The results of HSA have been first compared with those obtained using the Genetic Algorithm, and the Hill Climbing on a two-junction network for a fixed set of link flows. Secondly, the HSA with PFE has been applied to the medium-sized network to show the applicability of the proposed algorithm in solving the ENDP. Additionally, in order to test the sensitivity of perceived travel time error, we have used the HSA with PFE with various level of perceived travel time. The results showed that the proposed method is quite simple and efficient in solving the ENDP.

  13. The Optimal Timing of Stage-2-Palliation After the Norwood Operation.

    Science.gov (United States)

    Meza, James M; Hickey, Edward; McCrindle, Brian; Blackstone, Eugene; Anderson, Brett; Overman, David; Kirklin, James K; Karamlou, Tara; Caldarone, Christopher; Kim, Richard; DeCampli, William; Jacobs, Marshall; Guleserian, Kristine; Jacobs, Jeffrey P; Jaquiss, Robert

    2018-01-01

    The effect of the timing of stage-2-palliation (S2P) on survival through single ventricle palliation remains unknown. This study investigated the optimal timing of S2P that minimizes pre-S2P attrition and maximizes post-S2P survival. The Congenital Heart Surgeons' Society's critical left ventricular outflow tract obstruction cohort was used. Survival analysis was performed using multiphase parametric hazard analysis. Separate risk factors for death after the Norwood and after S2P were identified. Based on the multivariable models, infants were stratified as low, intermediate, or high risk. Cumulative 2-year, post-Norwood survival was predicted. Optimal timing was determined using conditional survival analysis and plotted as 2-year, post-Norwood survival versus age at S2P. A Norwood operation was performed in 534 neonates from 21 institutions. The S2P was performed in 71%, at a median age of 5.1 months (IQR: 4.3 to 6.0), and 22% died after Norwood. By 5 years after S2P, 10% of infants had died. For low- and intermediate-risk infants, performing S2P after age 3 months was associated with 89% ± 3% and 82% ± 3% 2-year survival, respectively. Undergoing an interval cardiac reoperation or moderate-severe right ventricular dysfunction before S2P were high-risk features. Among high-risk infants, 2-year survival was 63% ± 5%, and even lower when S2P was performed before age 6 months. Performing S2P after age 3 months may optimize survival of low- and intermediate-risk infants. High-risk infants are unlikely to complete three-stage palliation, and early S2P may increase their risk of mortality. We infer that early referral for cardiac transplantation may increase their chance of survival. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  14. Optimization of photometric determination of U with arsenazo III for direct determination of U in steels, soils and waters

    International Nuclear Information System (INIS)

    Kosturiak, A.; Talanova, A.; Rurikova, D.; Kalavska, D.

    1984-01-01

    Conditions were optimized for the reaction of U(VI) with arsenazo III. Recommended as the optimal medium for photometric determination of uranium in the concentration range 0.5 to 50 μg U/ml was the glycine buffer with pH 1.2 to 2.2. The results of the suggested method have better reproducibility than those of the mineral acid procedure used so far. Complexone III should be added to mask the other cations accompanying uranium in steels, waters and rocks. (author)

  15. Resource Optimization in Distributed Real-Time Multimedia Applications

    NARCIS (Netherlands)

    Yang, R.; van der Mei, R.D.; Roubos, D.; Seinstra, F.J.; Bal, H.E.

    2012-01-01

    The research area of multimedia content analysis (MMCA) considers all aspects of the automated extraction of knowledge from multimedia archives and data streams. To adhere to strict time constraints, large-scalemultimedia applications typically are being executed on distributed systems consisting of

  16. Scheduling with Optimized Communication for Time-Triggered Embedded Systems

    DEFF Research Database (Denmark)

    Pop, Paul; Eles, Petru; Peng, Zebo

    1999-01-01

    We present an approach to process scheduling for synthesis of safety-critical distributed embedded systems.Our system model captures both the flow of data and that of control. The communication model is based on a time-triggered protocol. We take into consideration overheads due to communication...

  17. Real-time composition determination of gas mixtures

    NARCIS (Netherlands)

    Lötters, Joost Conrad; van der Wouden, E.J.; Groenesteijn, Jarno; Sparreboom, Wouter; Lammerink, Theodorus S.J.; Wiegerink, Remco J.

    2014-01-01

    We have designed and implemented an analytical calculation model with which we can real-time determine the composition of gas mixtures. The model is based upon a multi-parameter flow measurement system, consisting of a Coriolis and thermal flow sensor, a density meter and a pressure sensor. The

  18. Optease Vena Cava Filter Optimal Indwelling Time and Retrievability

    International Nuclear Information System (INIS)

    Rimon, Uri; Bensaid, Paul; Golan, Gil; Garniek, Alexander; Khaitovich, Boris; Dotan, Zohar; Konen, Eli

    2011-01-01

    The purpose of this study was to assess the indwelling time and retrievability of the Optease IVC filter. Between 2002 and 2009, a total of 811 Optease filters were inserted: 382 for prophylaxis in multitrauma patients and 429 for patients with venous thromboembolic (VTE) disease. In 139 patients [97 men and 42 women; mean age, 36 (range, 17–82) years], filter retrieval was attempted. They were divided into two groups to compare change in retrieval policy during the years: group A, 60 patients with filter retrievals performed before December 31 2006; and group B, 79 patients with filter retrievals from January 2007 to October 2009. A total of 128 filters were successfully removed (57 in group A, and 71 in group B). The mean filter indwelling time in the study group was 25 (range, 3–122) days. In group A the mean indwelling time was 18 (range, 7–55) days and in group B 31 days (range, 8–122). There were 11 retrieval failures: 4 for inability to engage the filter hook and 7 for inability to sheathe the filter due to intimal overgrowth. The mean indwelling time of group A retrieval failures was 16 (range, 15–18) days and in group B 54 (range, 17–122) days. Mean fluoroscopy time for successful retrieval was 3.5 (range, 1–16.6) min and for retrieval failures 25.2 (range, 7.2–62) min. Attempts to retrieve the Optease filter can be performed up to 60 days, but more failures will be encountered with this approach.

  19. A novel weight determination method for time series data aggregation

    Science.gov (United States)

    Xu, Paiheng; Zhang, Rong; Deng, Yong

    2017-09-01

    Aggregation in time series is of great importance in time series smoothing, predicting and other time series analysis process, which makes it crucial to address the weights in times series correctly and reasonably. In this paper, a novel method to obtain the weights in time series is proposed, in which we adopt induced ordered weighted aggregation (IOWA) operator and visibility graph averaging (VGA) operator and linearly combine the weights separately generated by the two operator. The IOWA operator is introduced to the weight determination of time series, through which the time decay factor is taken into consideration. The VGA operator is able to generate weights with respect to the degree distribution in the visibility graph constructed from the corresponding time series, which reflects the relative importance of vertices in time series. The proposed method is applied to two practical datasets to illustrate its merits. The aggregation of Construction Cost Index (CCI) demonstrates the ability of proposed method to smooth time series, while the aggregation of The Taiwan Stock Exchange Capitalization Weighted Stock Index (TAIEX) illustrate how proposed method maintain the variation tendency of original data.

  20. Evaluation of optimal scan duration and end time in cerebral CT perfusion study

    International Nuclear Information System (INIS)

    Hirata, Masaaki; Sugawara, Yoshifumi; Miki, Hitoshi; Mochizuki, Teruhito; Murase, Kenya

    2005-01-01

    The purpose of this study was to evaluate the optimal end time of scanning and the influence of varying the number of source images adopted for calculation of the parameter values in computerized tomography (CT) perfusion. Nineteen CT perfusion studies in 14 patients with cerebrovascular disease were retrospectively analyzed. CT perfusion scanning was performed using continuous scans of 1 sec/rotation x 60 sec with 5-mm-thick sections. To determine the appropriate end time of scanning, the time-density curves (TDCs) of the anterior cerebral artery (ACA), superior sagittal sinus (SSS), and basal ganglia were analyzed. The functional maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were retrospectively generated from various numbers (30, 35, 40, 45, 50, 55, and 60) of source images. Defining the values calculated from the number of source images equal to the end time of the first pass as standard values, the percentage difference between the standard values and the values generated from various numbers of sources were evaluated. The TDCs of SSS showed the latest end time of the first pass (mean, 38.6±5.2 sec; range, 32 to 48 sec). Therefore, the values calculated from the number of source images equal to the end time of the first pass of SSS were defined as standard values. Increase and decrease of the number of source images for calculation resulted in increase of the percentage difference in every parameter value. The percentage differences ranged up to 49.6% for CBF, 48.0% for CBV, and 20.0% for MTT. Scanning until the end time of the first pass of SSS is necessary and sufficient for reliable measurement. Variable scan time based on the TDC of the SSS may be of better utility than use of fixed scan time. Further, the radiation dose could be minimized in many cases by reducing the scan time. (author)

  1. Sporadic insulinomas on volume perfusion CT: dynamic enhancement patterns and timing of optimal tumour-parenchyma contrast

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Liang; Xue, Hua-dan; Liu, Wei; Wang, Xuan; Sun, Hao; Li, Ping; Jin, Zheng-yu [Peking Union Medical College Hospital, Department of Radiology, Beijing (China); Wu, Wen-ming; Zhao, Yu-pei [Peking Union Medical College Hospital, Department of General Surgery, Beijing (China)

    2017-08-15

    To assess enhancement patterns of sporadic insulinomas on volume perfusion CT (VPCT), and to identify timing of optimal tumour-parenchyma contrast. Consecutive patients who underwent VPCT for clinically suspected insulinomas were retrospectively identified. Patients with insulinomas confirmed by surgery were included, and patients with familial syndromes were excluded. Two radiologists evaluated VPCT images in consensus. Tumour-parenchyma contrast at each time point was measured, and timing of optimal contrast was determined. Time duration of hyperenhancement (tumour-parenchyma contrast >20 Hounsfield units, HU) was recorded. Perfusion parameters were evaluated. Three dynamic enhancement patterns were observed in 63 tumours: persistent hyperenhancement (hyperenhancement time window ≥10 s) in 39 (61.9%), transient hyperenhancement (hyperenhancement <10 s) in 19 (30.2%) and non-hyperenhancement in 5 (7.9%). Timing of optimal contrast was 9 s after abdominal aorta threshold (AAT) of 200 HU, with tumour-parenchyma contrast of 77.6 ± 57.2 HU. At 9 s after AAT, 14 (22.2%) tumours were non-hyperenhancing, nine of which had missed transient hyperenhancement. Insulinomas with transient and persistent hyperenhancement patterns had significantly increased perfusion. Insulinomas have variable enhancement patterns. Tumour-parenchyma contrast is time-dependent. Optimal timing of enhancement is 9 s after AAT. VPCT enables tumour detection even if the hyperenhancement is transient. (orig.)

  2. Optimizing the Time Performance of Subcontractors in Building Projects

    Directory of Open Access Journals (Sweden)

    Andy K.W Ng

    2010-07-01

    Full Text Available The main contractors of Hong Kong building projects tend to subcontract most of their work. However, many of the subcontractors complain that they are not being fully utilized due main contractors’ poor site coordination of temporary works and interfacing works and plant supports etc. A list of critical site coordination problems caused by main contractors that had adversely influence to the time performance of subcontractors was prepared. A questionnaire survey was conducted to collect data to generate multiple regression equations that explain how the critical site coordination problems affected the time performance of different types of subcontractor. The survey results were validated by neural network analysis. Backward elimination method was adopted to identify the ‘most critical’ site coordination problems that enable main contractors to formulate measures to enhance their site management system.

  3. Time varying determinants of bond flows to emerging markets

    Directory of Open Access Journals (Sweden)

    Yasemin Erduman

    2016-06-01

    Full Text Available This paper investigates the time varying nature of the determinants of bond flows with a focus on the global financial crisis period. We estimate a time varying regression model using Bayesian estimation methods, where the posterior distribution is approximated by Gibbs sampling algorithm. Our findings suggest that the interest rate differential is the most significant pull factor of portfolio bond flows, along with the inflation rate, while the growth rate does not play a significant role. Among the push factors, global liquidity is the most important driver of bond flows. It matters the most, when unconventional monetary easing policies were first announced; and its importance as a determinant of portfolio bond flows decreases over time, starting with the Eurozone crisis, and diminishes with the tapering talk. Global risk appetite and the risk perception towards the emerging countries also have relatively small and stable significant effects on bond flows.

  4. Changes in Optimism Are Associated with Changes in Health Over Time Among Older Adults.

    Science.gov (United States)

    Chopik, William J; Kim, Eric S; Smith, Jacqui

    2015-09-01

    Little is known about how optimism differs by age and changes over time, particularly among older adults. Even less is known about how changes in optimism are related to changes in physical health. We examined age differences and longitudinal changes in optimism in 9,790 older adults over a four-year period. We found an inverted U-shaped pattern between optimism and age both cross-sectionally and longitudinally, such that optimism generally increased in older adults before decreasing. Increases in optimism over a four-year period were associated with improvements in self-rated health and fewer chronic illnesses over the same time frame. The findings from the current study are consistent with changes in emotion regulation strategies employed by older adults and age-related changes in well-being.

  5. Changes in Optimism Are Associated with Changes in Health Over Time Among Older Adults

    Science.gov (United States)

    Chopik, William J.; Kim, Eric S.; Smith, Jacqui

    2016-01-01

    Little is known about how optimism differs by age and changes over time, particularly among older adults. Even less is known about how changes in optimism are related to changes in physical health. We examined age differences and longitudinal changes in optimism in 9,790 older adults over a four-year period. We found an inverted U-shaped pattern between optimism and age both cross-sectionally and longitudinally, such that optimism generally increased in older adults before decreasing. Increases in optimism over a four-year period were associated with improvements in self-rated health and fewer chronic illnesses over the same time frame. The findings from the current study are consistent with changes in emotion regulation strategies employed by older adults and age-related changes in well-being. PMID:27114753

  6. Blocking Optimality in Distributed Real-Time Locking Protocols

    Directory of Open Access Journals (Sweden)

    Björn Bernhard Brandenburg

    2014-09-01

    Full Text Available Lower and upper bounds on the maximum priority inversion blocking (pi-blocking that is generally unavoidable in distributed multiprocessor real-time locking protocols (where resources may be accessed only from specific synchronization processors are established. Prior work on suspension-based shared-memory multiprocessor locking protocols (which require resources to be accessible from all processors has established asymptotically tight bounds of Ω(m and Ω(n maximum pi-blocking under suspension-oblivious and suspension-aware analysis, respectively, where m denotes the total number of processors and n denotes the number of tasks. In this paper, it is shown that, in the case of distributed semaphore protocols, there exist two different task allocation scenarios that give rise to distinct lower bounds. In the case of co-hosted task allocation, where application tasks may also be assigned to synchronization processors (i.e., processors hosting critical sections, Ω(Φ · n maximum pi-blocking is unavoidable for some tasks under any locking protocol under both suspension-aware and suspension-oblivious schedulability analysis, where Φ denotes the ratio of the maximum response time to the shortest period. In contrast, in the case of disjoint task allocation (i.e., if application tasks may not be assigned to synchronization processors, only Ω(m and Ω(n maximum pi-blocking is fundamentally unavoidable under suspension-oblivious and suspension-aware analysis, respectively, as in the shared-memory case. These bounds are shown to be asymptotically tight with the construction of two new distributed real-time locking protocols that ensure O(m and O(n maximum pi-blocking under suspension-oblivious and suspension-aware analysis, respectively.

  7. Optimization of Signal Timing of Intersections by Internal Metering of Queue Time Ratio of Vehicles in Network Scale

    Directory of Open Access Journals (Sweden)

    Mina Ghanbarikarekani

    2016-06-01

    Full Text Available Optimization of signal timing in urban network is usually done by minimizing the delay times or queue lengths. Sincethe effect of each intersection on the whole network is not considered in the mentioned methods, traffic congestion may occur in network links. Therefore, this paper has aimed to provide a timing optimization algorithm for traffic signals using internal timing policy based on balancing queue time ratio of vehicles in network links. In the proposed algorithm, the difference between the real queue time ratio and the optimum one for each link of intersection was minimized. To evaluate the efficiency of the proposed algorithm on traffic performance, the proposed algorithm was applied in a hypothetical network. By comparing the simulating software outputs, before and after implementing the algorithm, it was concluded that the queue time ratio algorithm has improved the traffic parameters by increasing the flow as well as reducing the delay time and density of the network.

  8. FEM for time-fractional diffusion equations, novel optimal error analyses

    OpenAIRE

    Mustapha, Kassem

    2016-01-01

    A semidiscrete Galerkin finite element method applied to time-fractional diffusion equations with time-space dependent diffusivity on bounded convex spatial domains will be studied. The main focus is on achieving optimal error results with respect to both the convergence order of the approximate solution and the regularity of the initial data. By using novel energy arguments, for each fixed time $t$, optimal error bounds in the spatial $L^2$- and $H^1$-norms are derived for both cases: smooth...

  9. Optimal moment determination in POME-copula based hydrometeorological dependence modelling

    Science.gov (United States)

    Liu, Dengfeng; Wang, Dong; Singh, Vijay P.; Wang, Yuankun; Wu, Jichun; Wang, Lachun; Zou, Xinqing; Chen, Yuanfang; Chen, Xi

    2017-07-01

    Copula has been commonly applied in multivariate modelling in various fields where marginal distribution inference is a key element. To develop a flexible, unbiased mathematical inference framework in hydrometeorological multivariate applications, the principle of maximum entropy (POME) is being increasingly coupled with copula. However, in previous POME-based studies, determination of optimal moment constraints has generally not been considered. The main contribution of this study is the determination of optimal moments for POME for developing a coupled optimal moment-POME-copula framework to model hydrometeorological multivariate events. In this framework, margins (marginals, or marginal distributions) are derived with the use of POME, subject to optimal moment constraints. Then, various candidate copulas are constructed according to the derived margins, and finally the most probable one is determined, based on goodness-of-fit statistics. This optimal moment-POME-copula framework is applied to model the dependence patterns of three types of hydrometeorological events: (i) single-site streamflow-water level; (ii) multi-site streamflow; and (iii) multi-site precipitation, with data collected from Yichang and Hankou in the Yangtze River basin, China. Results indicate that the optimal-moment POME is more accurate in margin fitting and the corresponding copulas reflect a good statistical performance in correlation simulation. Also, the derived copulas, capturing more patterns which traditional correlation coefficients cannot reflect, provide an efficient way in other applied scenarios concerning hydrometeorological multivariate modelling.

  10. Rapid Titration of Measles and Other Viruses: Optimization with Determination of Replication Cycle Length

    Science.gov (United States)

    Grigorov, Boyan; Rabilloud, Jessica; Lawrence, Philip; Gerlier, Denis

    2011-01-01

    Background Measles virus (MV) is a member of the Paramyxoviridae family and an important human pathogen causing strong immunosuppression in affected individuals and a considerable number of deaths worldwide. Currently, measles is a re-emerging disease in developed countries. MV is usually quantified in infectious units as determined by limiting dilution and counting of plaque forming unit either directly (PFU method) or indirectly from random distribution in microwells (TCID50 method). Both methods are time-consuming (up to several days), cumbersome and, in the case of the PFU assay, possibly operator dependent. Methods/Findings A rapid, optimized, accurate, and reliable technique for titration of measles virus was developed based on the detection of virus infected cells by flow cytometry, single round of infection and titer calculation according to the Poisson's law. The kinetics follow up of the number of infected cells after infection with serial dilutions of a virus allowed estimation of the duration of the replication cycle, and consequently, the optimal infection time. The assay was set up to quantify measles virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus type 1 (HIV-1) using antibody labeling of viral glycoprotein, virus encoded fluorescent reporter protein and an inducible fluorescent-reporter cell line, respectively. Conclusion Overall, performing the assay takes only 24–30 hours for MV strains, 12 hours for VSV, and 52 hours for HIV-1. The step-by-step procedure we have set up can be, in principle, applicable to accurately quantify any virus including lentiviral vectors, provided that a virus encoded gene product can be detected by flow cytometry. PMID:21915289

  11. Optimization Extracting Technology of Cynomorium songaricum Rupr. Saponins by Ultrasonic and Determination of Saponins Content in Samples with Different Source

    OpenAIRE

    Xiaoli Wang; Qingwei Wei; Xinqiang Zhu; Chunmei Wang; Yonggang Wang; Peng Lin; Lin Yang

    2015-01-01

    Extraction process was optimized by single factor and orthogonal experiment (L9 (34)). Moreover, the content determination was studied in methodology. The optimum ultrasonic extraction conditions were: ethanol concentration of 75%, ultrasonic power of 420 w, the solid-liquid ratio of 1:15, extraction duration of 45 min, extraction temperature of 90°C and extraction for 2 times. Saponins content in Guazhou samples was significantly higher than those in Xinjiang and Inner Mongolia. Meanwhile, G...

  12. Application of Time Series Analysis in Determination of Lag Time in Jahanbin Basin

    Directory of Open Access Journals (Sweden)

    Seied Yahya Mirzaee

    2005-11-01

        One of the important issues that have significant role in study of hydrology of basin is determination of lag time. Lag time has significant role in hydrological studies. Quantity of rainfall related lag time depends on several factors, such as permeability, vegetation cover, catchments slope, rainfall intensity, storm duration and type of rain. Determination of lag time is important parameter in many projects such as dam design and also water resource studies. Lag time of basin could be calculated using various methods. One of these methods is time series analysis of spectral density. The analysis is based on fouries series. The time series is approximated with Sinuous and Cosines functions. In this method harmonically significant quantities with individual frequencies are presented. Spectral density under multiple time series could be used to obtain basin lag time for annual runoff and short-term rainfall fluctuation. A long lag time could be due to snowmelt as well as melting ice due to rainfalls in freezing days. In this research the lag time of Jahanbin basin has been determined using spectral density method. The catchments is subjected to both rainfall and snowfall. For short term rainfall fluctuation with a return period  2, 3, 4 months, the lag times were found 0.18, 0.5 and 0.083 month, respectively.

  13. Real-Time Dosimetry and Optimization of Prostate Photodynamic Therapy

    Science.gov (United States)

    2005-05-01

    85cm’ 0:k -" l)=O5.0O25,=0.10cnf’ Ps4 ൱ crm’ 0 cik)=5.012p 5,4=5.45c,1’. G~cff’* - 0~n) .012,P. 0.49cff’,0:=3.56c-0 cink) = - 1,00 c ’", V-= 1.75 ccml...tissue to make a measurement. This limits the resolution of absorption spectroscopy, and makes it more time- consuming than fluorescence spectroscopy...photobleaching versus those that do not. Further research into the photobleaching behavior and in vivo vascular effects of MLu is needed to resolve the

  14. [Just-in-time initiation of optimal dialysis].

    Science.gov (United States)

    Cornelis, Tom; Kooman, Jeroen P; van der Sande, Frank M

    2010-01-01

    The IDEAL trial shows that the decision to start renal replacement treatment should not depend on GFR alone, but should be taken on the basis of clinical parameters. Quality of Life (QoL) questionnaires and bio-impedance analysis are potential tools for detecting subtle changes in the predialysis clinic. Too early an initiation of dialysis may be deleterious for the patient and the healthcare system. We are convinced that ESRD patients should be informed about intensive haemodialysis (HD), especially nocturnal (home) HD, as the best available dialysis modality. There is substantial evidence which shows that intensive HD improves clinical, biochemical and biological parameters, and may even prolong survival. We believe that 'just-in-time delivery of intensive haemodialysis' may result in optimised QoL and reduced economic burden.

  15. Sumoylation promotes optimal APC/C Activation and Timely Anaphase.

    Science.gov (United States)

    Lee, Christine C; Li, Bing; Yu, Hongtao; Matunis, Michael J

    2018-03-08

    The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC/C activity is controlled by an interplay of multiple pathways during mitosis, including the spindle assembly checkpoint (SAC), that are not yet fully understood. Here, we show that sumoylation of the APC4 subunit of the APC/C peaks during mitosis and is critical for timely APC/C activation and anaphase onset. We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the APC4 sumoylation sites and APC/C catalytic core. Our findings provide evidence of an important regulatory role for SUMO modification and binding in affecting APC/C activation and mitotic exit. © 2018, Lee et al.

  16. Determinants of Change in Children’s Sedentary Time

    Science.gov (United States)

    Atkin, Andrew J.; Corder, Kirsten; Ekelund, Ulf; Wijndaele, Katrien; Griffin, Simon J.; van Sluijs, Esther M. F.

    2013-01-01

    Background Understanding the determinants of sedentary time during childhood contributes to the development of effective intervention programmes. Purpose To examine family and home-environmental determinants of 1-year change in objectively measured sedentary time after-school and at the weekend. Methods Participants wore accelerometers at baseline and 1 year later. Longitudinal data for after-school and weekend analyses were available for 854 (41.5%male, mean±SD age 10.2±0.3years) and 718 (41.8%male, age 10.2±0.3years) participants. Information on 26 candidate determinants, including socioeconomic status (SES), availability of electronic media and parental rules for sedentary behaviours was self-reported by children or their parents at baseline. Change in the proportion of registered time spent sedentary was used as the outcome variable in multi-level linear regression models, adjusted for age, sex, body mass index and baseline sedentary time. Simple and multiple models were run and interactions with sex explored. Results Children from higher socioeconomic status families exhibited greater increases in after-school (beta; 95% CI for change in % time spent sedentary 1.02; 0.37, 1.66) and weekend (1.42; 0.65, 2.18) sedentary time. Smaller increases in after-school sedentary time were observed in children with more siblings (−1.00; −1.69, −0.30), greater availability of electronic media (−0.81; −1.29, −0.33) and, for boys, more frequent family visits to the park (−1.89; −3.28, −0.51) and family participation in sport (−1.28; −2.54, −0.02). Greater maternal weekend screen-time (0.45; 0.08, 0.83) and, in girls, greater parental restriction on playing outside (0.91; 0.08, 1.74) were associated with larger increases in weekend sedentary time. The analytical sample was younger, more likely to be female, had lower BMI and was of higher SES than the original baseline sample. Conclusions Intervention strategies aimed at reducing parents’ weekend

  17. On-Board Real-Time Optimization Control for Turbo-Fan Engine Life Extending

    Science.gov (United States)

    Zheng, Qiangang; Zhang, Haibo; Miao, Lizhen; Sun, Fengyong

    2017-11-01

    A real-time optimization control method is proposed to extend turbo-fan engine service life. This real-time optimization control is based on an on-board engine mode, which is devised by a MRR-LSSVR (multi-input multi-output recursive reduced least squares support vector regression method). To solve the optimization problem, a FSQP (feasible sequential quadratic programming) algorithm is utilized. The thermal mechanical fatigue is taken into account during the optimization process. Furthermore, to describe the engine life decaying, a thermal mechanical fatigue model of engine acceleration process is established. The optimization objective function not only contains the sub-item which can get fast response of the engine, but also concludes the sub-item of the total mechanical strain range which has positive relationship to engine fatigue life. Finally, the simulations of the conventional optimization control which just consider engine acceleration performance or the proposed optimization method have been conducted. The simulations demonstrate that the time of the two control methods from idle to 99.5 % of the maximum power are equal. However, the engine life using the proposed optimization method could be surprisingly increased by 36.17 % compared with that using conventional optimization control.

  18. Optimal timing of valve replacement in asymptomatic severe aortic stenosis.

    Science.gov (United States)

    Bilen, Emine; Ipek, Gökürk; Ayhan, Huseyin; Nacar, Alper Bugra; Kasapkara, Haci Ahmet; Sani, Cenk; Basbug, Serdar; Kurt, Mustafa; Bozkurt, Engin

    2014-09-01

    Patients with asymptomatic severe aortic stenosis (AS) constitute a heterogeneous group which includes not only certain cases who are at high risk of sudden death and valve-related heart failure, but also those at low risk for these events. Degenerative AS, which includes a majority of patients with AS, is characterized by stricture of the valve, increased arterial stiffness, and diverse left ventricular response to the valvular plus arterial vascular load. In addition to using traditional primary parameters, the severity of AS and the total left ventricular load should be assessed using new measures such as energy loss index and valvulo-arterial impedance. Natriuretic peptide levels and global longitudinal strain imaging may also be used as secondary parameters to obtain information about left ventricular systolic function, although these parameters do not correlate with the severity of AS. Exercise stress testing and exercise echocardiography are also beneficial when assessing the patient if they are symptomatic, and for determining valvular and left ventricular contractile reserves. The aim of this review was to emphasize the importance of risk stratifications in asymptomatic severe AS cases, and to assess the severity of AS using not only conventional methods but also new methods on which much emphasis has been placed during recent years.

  19. Signal Timing Optimization Based on Fuzzy Compromise Programming for Isolated Signalized Intersection

    Directory of Open Access Journals (Sweden)

    Dexin Yu

    2016-01-01

    Full Text Available In order to optimize the signal timing for isolated intersection, a new method based on fuzzy programming approach is proposed in this paper. Considering the whole operation efficiency of the intersection comprehensively, traffic capacity, vehicle cycle delay, cycle stops, and exhaust emission are chosen as optimization goals to establish a multiobjective function first. Then fuzzy compromise programming approach is employed to give different weight coefficients to various optimization objectives for different traffic flow ratios states. And then the multiobjective function is converted to a single objective function. By using genetic algorithm, the optimized signal cycle and effective green time can be obtained. Finally, the performance of the traditional method and new method proposed in this paper is compared and analyzed through VISSIM software. It can be concluded that the signal timing optimized in this paper can effectively reduce vehicle delays and stops, which can improve traffic capacity of the intersection as well.

  20. Real-time determination of confinement parameters in JET

    International Nuclear Information System (INIS)

    Barana, Oliviero; Joffrin, E.; Murari, A.; Sartori, F.

    2003-01-01

    The main confinement parameters, like the internal inductance l i and the diamagnetic poloidal beta β DIA , are of particular relevance for a reliable real-time control system of next step tokamaks. These quantities have been obtained at Joint European Torus (JET), with a precision more than satisfactory for real-time applications, through a method, known as BETALI, that uses the Shafranov integrals S 1 , S 2 and S 3 . Since S 1 , S 2 and S 3 are defined on the plasma boundary, a technique, that exploits the real-time boundary code XLOC, has been expressively developed to determine the last closed flux surface (LCFS). BETALI has been verified on several experimental plasma configurations, giving very encouraging results both in the limiter and x-point phase of the discharges. The compatibility with the time restrictions has also been tested successfully. This application has, therefore, been implemented and it has already been used during last JET campaigns

  1. Using Maximal Isometric Force to Determine the Optimal Load for Measuring Dynamic Muscle Power

    Science.gov (United States)

    Spiering, Barry A.; Lee, Stuart M. C.; Mulavara, Ajitkumar P.; Bentley, Jason R.; Nash, Roxanne E.; Sinka, Joseph; Bloomberg, Jacob J.

    2009-01-01

    Maximal power output occurs when subjects perform ballistic exercises using loads of 30-50% of one-repetition maximum (1-RM). However, performing 1-RM testing prior to power measurement requires considerable time, especially when testing involves multiple exercises. Maximal isometric force (MIF), which requires substantially less time to measure than 1-RM, might be an acceptable alternative for determining the optimal load for power testing. PURPOSE: To determine the optimal load based on MIF for maximizing dynamic power output during leg press and bench press exercises. METHODS: Twenty healthy volunteers (12 men and 8 women; mean +/- SD age: 31+/-6 y; body mass: 72 +/- 15 kg) performed isometric leg press and bench press movements, during which MIF was measured using force plates. Subsequently, subjects performed ballistic leg press and bench press exercises using loads corresponding to 20%, 30%, 40%, 50%, and 60% of MIF presented in randomized order. Maximal instantaneous power was calculated during the ballistic exercise tests using force plates and position transducers. Repeated-measures ANOVA and Fisher LSD post hoc tests were used to determine the load(s) that elicited maximal power output. RESULTS: For the leg press power test, six subjects were unable to be tested at 20% and 30% MIF because these loads were less than the lightest possible load (i.e., the weight of the unloaded leg press sled assembly [31.4 kg]). For the bench press power test, five subjects were unable to be tested at 20% MIF because these loads were less than the weight of the unloaded aluminum bar (i.e., 11.4 kg). Therefore, these loads were excluded from analysis. A trend (p = 0.07) for a main effect of load existed for the leg press exercise, indicating that the 40% MIF load tended to elicit greater power output than the 60% MIF load (effect size = 0.38). A significant (p . 0.05) main effect of load existed for the bench press exercise; post hoc analysis indicated that the effect of

  2. Optimization of thermal systems based on finite-time thermodynamics and thermoeconomics

    Energy Technology Data Exchange (ETDEWEB)

    Durmayaz, A. [Istanbul Technical University (Turkey). Department of Mechanical Engineering; Sogut, O.S. [Istanbul Technical University, Maslak (Turkey). Department of Naval Architecture and Ocean Engineering; Sahin, B. [Yildiz Technical University, Besiktas, Istanbul (Turkey). Department of Naval Architecture; Yavuz, H. [Istanbul Technical University, Maslak (Turkey). Institute of Energy

    2004-07-01

    The irreversibilities originating from finite-time and finite-size constraints are important in the real thermal system optimization. Since classical thermodynamic analysis based on thermodynamic equilibrium do not consider these constraints directly, it is necessary to consider the energy transfer between the system and its surroundings in the rate form. Finite-time thermodynamics provides a fundamental starting point for the optimization of real thermal systems including the fundamental concepts of heat transfer and fluid mechanics to classical thermodynamics. In this study, optimization studies of thermal systems, that consider various objective functions, based on finite-time thermodynamics and thermoeconomics are reviewed. (author)

  3. Spectrophotometric determination of fluoxetine by molecularly imprinted polypyrrole and optimization by experimental design, artificial neural network and genetic algorithm

    Science.gov (United States)

    Nezhadali, Azizollah; Motlagh, Maryam Omidvar; Sadeghzadeh, Samira

    2018-02-01

    A selective method based on molecularly imprinted polymer (MIP) solid-phase extraction (SPE) using UV-Vis spectrophotometry as a detection technique was developed for the determination of fluoxetine (FLU) in pharmaceutical and human serum samples. The MIPs were synthesized using pyrrole as a functional monomer in the presence of FLU as a template molecule. The factors that affecting the preparation and extraction ability of MIP such as amount of sorbent, initiator concentration, the amount of monomer to template ratio, uptake shaking rate, uptake time, washing buffer pH, take shaking rate, Taking time and polymerization time were considered for optimization. First a Plackett-Burman design (PBD) consists of 12 randomized runs were applied to determine the influence of each factor. The other optimization processes were performed using central composite design (CCD), artificial neural network (ANN) and genetic algorithm (GA). At optimal condition the calibration curve showed linearity over a concentration range of 10- 7-10- 8 M with a correlation coefficient (R2) of 0.9970. The limit of detection (LOD) for FLU was obtained 6.56 × 10- 9 M. The repeatability of the method was obtained 1.61%. The synthesized MIP sorbent showed a good selectivity and sensitivity toward FLU. The MIP/SPE method was used for the determination of FLU in pharmaceutical, serum and plasma samples, successfully.

  4. Spectrophotometric determination of fluoxetine by molecularly imprinted polypyrrole and optimization by experimental design, artificial neural network and genetic algorithm.

    Science.gov (United States)

    Nezhadali, Azizollah; Motlagh, Maryam Omidvar; Sadeghzadeh, Samira

    2018-02-05

    A selective method based on molecularly imprinted polymer (MIP) solid-phase extraction (SPE) using UV-Vis spectrophotometry as a detection technique was developed for the determination of fluoxetine (FLU) in pharmaceutical and human serum samples. The MIPs were synthesized using pyrrole as a functional monomer in the presence of FLU as a template molecule. The factors that affecting the preparation and extraction ability of MIP such as amount of sorbent, initiator concentration, the amount of monomer to template ratio, uptake shaking rate, uptake time, washing buffer pH, take shaking rate, Taking time and polymerization time were considered for optimization. First a Plackett-Burman design (PBD) consists of 12 randomized runs were applied to determine the influence of each factor. The other optimization processes were performed using central composite design (CCD), artificial neural network (ANN) and genetic algorithm (GA). At optimal condition the calibration curve showed linearity over a concentration range of 10 -7 -10 -8 M with a correlation coefficient (R 2 ) of 0.9970. The limit of detection (LOD) for FLU was obtained 6.56×10 -9 M. The repeatability of the method was obtained 1.61%. The synthesized MIP sorbent showed a good selectivity and sensitivity toward FLU. The MIP/SPE method was used for the determination of FLU in pharmaceutical, serum and plasma samples, successfully. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Optimal Hedging and Pricing of Equity-Linked Life Insurance Contracts in a Discrete-Time Incomplete Market

    Directory of Open Access Journals (Sweden)

    Norman Josephy

    2011-01-01

    Full Text Available We present a method of optimal hedging and pricing of equity-linked life insurance products in an incomplete discrete-time financial market. A pure endowment life insurance contract with guarantee is used as an example. The financial market incompleteness is caused by the assumption that the underlying risky asset price ratios are distributed in a compact interval, generalizing the assumptions of multinomial incomplete market models. For a range of initial hedging capitals for the embedded financial option, we numerically solve an optimal hedging problem and determine a risk-return profile of each optimal non-self-financing hedging strategy. The fair price of the insurance contract is determined according to the insurer's risk-return preferences. Illustrative numerical results of testing our algorithm on hypothetical insurance contracts are documented. A discussion and a test of a hedging strategy recalibration technique for long-term contracts are presented.

  6. Optimal timing of joint replacement using mathematical programming and stochastic programming models.

    Science.gov (United States)

    Keren, Baruch; Pliskin, Joseph S

    2011-12-01

    The optimal timing for performing radical medical procedures as joint (e.g., hip) replacement must be seriously considered. In this paper we show that under deterministic assumptions the optimal timing for joint replacement is a solution of a mathematical programming problem, and under stochastic assumptions the optimal timing can be formulated as a stochastic programming problem. We formulate deterministic and stochastic models that can serve as decision support tools. The results show that the benefit from joint replacement surgery is heavily dependent on timing. Moreover, for a special case where the patient's remaining life is normally distributed along with a normally distributed survival of the new joint, the expected benefit function from surgery is completely solved. This enables practitioners to draw the expected benefit graph, to find the optimal timing, to evaluate the benefit for each patient, to set priorities among patients and to decide if joint replacement should be performed and when.

  7. Off-Policy Reinforcement Learning: Optimal Operational Control for Two-Time-Scale Industrial Processes.

    Science.gov (United States)

    Li, Jinna; Kiumarsi, Bahare; Chai, Tianyou; Lewis, Frank L; Fan, Jialu

    2017-12-01

    Industrial flow lines are composed of unit processes operating on a fast time scale and performance measurements known as operational indices measured at a slower time scale. This paper presents a model-free optimal solution to a class of two time-scale industrial processes using off-policy reinforcement learning (RL). First, the lower-layer unit process control loop with a fast sampling period and the upper-layer operational index dynamics at a slow time scale are modeled. Second, a general optimal operational control problem is formulated to optimally prescribe the set-points for the unit industrial process. Then, a zero-sum game off-policy RL algorithm is developed to find the optimal set-points by using data measured in real-time. Finally, a simulation experiment is employed for an industrial flotation process to show the effectiveness of the proposed method.

  8. Determination of time delay between ventricles contraction using impedance measurements

    International Nuclear Information System (INIS)

    Lewandowska, M; Poliński, A; Wtorek, J

    2013-01-01

    The paper presents a novel approach to assessment of ventricular dyssynchrony basing on multichannel electrical impedance measurements. Using a proper placement of electrodes, the sensitivity approach allows estimating time difference between chambers contraction from over determined nonlinear system of equations. The theoretical considerations which include Finite Element Method simulations were verified using measurements on healthy 28 year's old woman. The nonlinear least squares method was applied to obtain a time difference between heart chambers contraction. The obtained value was in a good agreement with theoretical values found in literature.

  9. Determinants of timely uptake of ITN and SP (IPT) and pregnancy time protected against malaria in Bukoba, Tanzania.

    Science.gov (United States)

    Protas, Joyce; Tarimo, D; Moshiro, C

    2016-06-21

    Insecticides treated nets (ITNs) and intermittent preventive therapy with two doses of sulfadoxine-pyrimethamine (SP IPTp) are the cornerstone for malaria control in pregnancy. Despite the coverage of these interventions being high, it is not known whether they confer optimal protection time against malaria in pregnancy. This study investigated the timing and determinants of timely uptake of SP(IPTp) and ITNs and the pregnancy time protected. A health facility based cross-sectional study was carried out in Bukoba urban district from 16th April to 29 May 2013. Involving pregnant women and post natal mothers attending Reproductive and Child Health (RCH) clinics. Data on their socio-economic background, pregnancy history and attendance to RCH, receipt of a voucher and acquisition of an ITN as well as SP for IPTp were collected. Their responses were validated from the records of antenatal cards. Data was analysed using SPSS computer program version 20. A total of 530 mothers were recruited. The overall uptake of SP IPTp was 96 % and the uptake of two SP (IPTp) doses was 86 %. Timely uptake of 1st dose was predicted by early antenatal booking, [AOR 2.59; 95 % CI 1.51-4.46; P = 0.001], and the availability of SP at the facility [AOR 4.63; 95 % CI 2.51-8.54; P discount vouchers at different gestational age and of these, less than a quarter (21.4 %) received timely. Timely receipt of discount voucher was highly predicted by early antenatal booking [AOR 200; 95 % CI 80.38-498; P discount vouchers for ITNs, timely uptake and therefore optimal protection time depended on early antenatal booking, the availability of (SP IPTp) and discount voucher at the health facility.

  10. The optimal time path of clean energy R&D policy when patents have finite lifetime

    NARCIS (Netherlands)

    Gerlagh, R.; Kverndokk, S.; Rosendahl, K.E.

    We study the optimal time path for clean energy innovation policy. In a model with emission reduction through clean energy deployment, and with R&D increasing the overall productivity of clean energy, we describe optimal R&D policies jointly with emission pricing policies. We find that while

  11. Optimal control of nonlinear continuous-time systems in strict-feedback form.

    Science.gov (United States)

    Zargarzadeh, Hassan; Dierks, Travis; Jagannathan, Sarangapani

    2015-10-01

    This paper proposes a novel optimal tracking control scheme for nonlinear continuous-time systems in strict-feedback form with uncertain dynamics. The optimal tracking problem is transformed into an equivalent optimal regulation problem through a feedforward adaptive control input that is generated by modifying the standard backstepping technique. Subsequently, a neural network-based optimal control scheme is introduced to estimate the cost, or value function, over an infinite horizon for the resulting nonlinear continuous-time systems in affine form when the internal dynamics are unknown. The estimated cost function is then used to obtain the optimal feedback control input; therefore, the overall optimal control input for the nonlinear continuous-time system in strict-feedback form includes the feedforward plus the optimal feedback terms. It is shown that the estimated cost function minimizes the Hamilton-Jacobi-Bellman estimation error in a forward-in-time manner without using any value or policy iterations. Finally, optimal output feedback control is introduced through the design of a suitable observer. Lyapunov theory is utilized to show the overall stability of the proposed schemes without requiring an initial admissible controller. Simulation examples are provided to validate the theoretical results.

  12. Optimal operation of smart houses by a real-time rolling horizon algorithm

    NARCIS (Netherlands)

    Paterakis, N.G.; Pappi, I.N.; Catalão, J.P.S.; Erdinc, O.

    2016-01-01

    In this paper, a novel real-time rolling horizon optimization framework for the optimal operation of a smart household is presented. A home energy management system (HEMS) model based on mixed-integer linear programming (MILP) is developed in order to minimize the energy procurement cost considering

  13. Optimal time-domain technique for pulse width modulation in power electronics

    Directory of Open Access Journals (Sweden)

    I. Mayergoyz

    2018-05-01

    Full Text Available Optimal time-domain technique for pulse width modulation is presented. It is based on exact and explicit analytical solutions for inverter circuits, obtained for any sequence of input voltage rectangular pulses. Two optimal criteria are discussed and illustrated by numerical examples.

  14. Free terminal time optimal control problem for the treatment of HIV infection

    Directory of Open Access Journals (Sweden)

    Amine Hamdache

    2016-01-01

    to provide the explicit formulations of the optimal controls. The corresponding optimality system with the additional transversality condition for the terminal time is derived and solved numerically using an adapted iterative method with a Runge-Kutta fourth order scheme and a gradient method routine.

  15. Use of multilevel modeling for determining optimal parameters of heat supply systems

    Science.gov (United States)

    Stennikov, V. A.; Barakhtenko, E. A.; Sokolov, D. V.

    2017-07-01

    The problem of finding optimal parameters of a heat-supply system (HSS) is in ensuring the required throughput capacity of a heat network by determining pipeline diameters and characteristics and location of pumping stations. Effective methods for solving this problem, i.e., the method of stepwise optimization based on the concept of dynamic programming and the method of multicircuit optimization, were proposed in the context of the hydraulic circuit theory developed at Melentiev Energy Systems Institute (Siberian Branch, Russian Academy of Sciences). These methods enable us to determine optimal parameters of various types of piping systems due to flexible adaptability of the calculation procedure to intricate nonlinear mathematical models describing features of used equipment items and methods of their construction and operation. The new and most significant results achieved in developing methodological support and software for finding optimal parameters of complex heat supply systems are presented: a new procedure for solving the problem based on multilevel decomposition of a heat network model that makes it possible to proceed from the initial problem to a set of interrelated, less cumbersome subproblems with reduced dimensionality; a new algorithm implementing the method of multicircuit optimization and focused on the calculation of a hierarchical model of a heat supply system; the SOSNA software system for determining optimum parameters of intricate heat-supply systems and implementing the developed methodological foundation. The proposed procedure and algorithm enable us to solve engineering problems of finding the optimal parameters of multicircuit heat supply systems having large (real) dimensionality, and are applied in solving urgent problems related to the optimal development and reconstruction of these systems. The developed methodological foundation and software can be used for designing heat supply systems in the Central and the Admiralty regions in

  16. Determination of P – wave arrival time of acoustic events

    Directory of Open Access Journals (Sweden)

    Matěj Petružálek

    2010-10-01

    Full Text Available The new approach to the P-wave arrival time determination based on acoustic emission data from loading experiments is tested.The algorithm used in this paper is built on the STA/LTA function computed by a convolution that speeds up the computation processvery much. The picking process makes use of shifting of temporary onset until certain conditions are fulfill and as a main decisioncriterion on the threshold exceeding of the STA/LTA derivation function is used. The P-wave onset time is determined in a selectedinterval that corresponds to the theoretical propagation of elastic wave in the rock sample. Results obtained by our algorithm werecorrelated with data acquired manually and a high order statistic software as well.

  17. Optimal timing of early versus delayed adjuvant radiotherapy following radical prostatectomy for locally advanced prostate cancer.

    Science.gov (United States)

    Kowalczyk, Keith J; Gu, Xiangmei; Nguyen, Paul L; Lipsitz, Stuart R; Trinh, Quoc-Dien; Lynch, John H; Collins, Sean P; Hu, Jim C

    2014-04-01

    Although post-radical prostatectomy (RP) adjuvant radiation therapy (ART) benefits disease that is staged as pT3 or higher, the optimal ART timing remains unknown. Our objective is to characterize the outcomes and optimal timing of early vs. delayed ART. From the Surveillance, Epidemiology and End Results-Medicare data from 1995 to 2007, we identified 963 men with pT3N0 disease receiving early (statistic approach to determine at what time post-RP ART had the most significant effect on outcomes of interest in men with pT3N0 disease. When compared with delayed ART in men with pT3 disease, early ART was associated with improved PCSM (0.47 vs. 1.02 events per 100 person-years; P = 0.038) and less salvage hormonal therapy (2.88 vs. 4.59 events per 100 person-years; P = 0.001). Delaying ART beyond 5 months is associated with worse PCSM (hazard ratio [HR] 2.3; P = 0.020), beyond 3 months is associated with more BRE (HR 1.6; P = 0.025), and beyond 4 months is associated higher rates of salvage hormonal therapy (HR 1.6; P = 0.002). ART performed after 9 months was associated with fewer urethral strictures (HR 0.6; P = 0.042). Initiating ART less than 5 months after RP for pT3 is associated with improved PCSM. Early ART is also associated with fewer BRE and less use of salvage hormonal therapy if administered earlier than 3 and 4 months after RP, respectively. However, ART administered later than 9 months after RP is associated with fewer urethral strictures. Our population-based findings complement randomized trials designed with fixed ART timing. © 2013 Published by Elsevier Inc.

  18. A hybrid condenser model for real-time applications in performance monitoring, control and optimization

    International Nuclear Information System (INIS)

    Ding Xudong; Cai Wenjian; Jia Lei; Wen Changyun; Zhang Guiqing

    2009-01-01

    In this paper, a simple, yet accurate hybrid modeling technique for condensers is presented. The method starts with fundamental physical principles but captures only few key operational characteristic parameters to predict the system performances. The advantages of the methods lie that linear or non-linear least-squares methods can be directly used to determine no more than four key operational characteristic parameters in the model, which can significantly reduce the computational burden. The developed model is verified with the experimental data taken from a pilot system. The testing results confirm that the proposed model can predict accurately the performance of the real-time operating condenser with the maximum error of less than ±10%. The model technique proposed will have wide applications not only in condenser operating optimization, but also in performance assessment and fault detection and diagnosis.

  19. Optimization of ramp area aircraft push back time windows in the presence of uncertainty

    Science.gov (United States)

    Coupe, William Jeremy

    It is well known that airport surface traffic congestion at major airports is responsible for increased taxi-out times, fuel burn and excess emissions and there is potential to mitigate these negative consequences through optimizing airport surface traffic operations. Due to a highly congested voice communication channel between pilots and air traffic controllers and a data communication channel that is used only for limited functions, one of the most viable near-term strategies for improvement of the surface traffic is issuing a push back advisory to each departing aircraft. This dissertation focuses on the optimization of a push back time window for each departing aircraft. The optimization takes into account both spatial and temporal uncertainties of ramp area aircraft trajectories. The uncertainties are described by a stochastic kinematic model of aircraft trajectories, which is used to infer distributions of combinations of push back times that lead to conflict among trajectories from different gates. The model is validated and the distributions are included in the push back time window optimization. Under the assumption of a fixed taxiway spot schedule, the computed push back time windows can be integrated with a higher level taxiway scheduler to optimize the flow of traffic from the gate to the departure runway queue. To enable real-time decision making the computational time of the push back time window optimization is critical and is analyzed throughout.

  20. Optimal timing of cholecystectomy in children with gallstone pancreatitis.

    Science.gov (United States)

    Badru, Faidah; Saxena, Saurabh; Breeden, Robert; Bourdillon, Maximillan; Fitzpatrick, Colleen; Chatoorgoon, Kaveer; Greenspon, Jose; Villalona, Gustavo

    2017-07-01

    Little data exist regarding the recurrence of pancreatitis in pediatric patients with gallstone pancreatitis awaiting cholecystectomy. This study evaluates the recurrence rate of pancreatitis after acute gallstone pancreatitis based on the timing of cholecystectomy in pediatric patients. A retrospective chart review of all patients admitted with gallstone pancreatitis from 2007 to 2015 was performed. Children were divided into the following five groups. Group 1 had surgery during the index admission. Group 2 had surgery within 2 wk of discharge. Group 3 had surgery between 2 and 6 wk postdischarge. Group 4 had surgery 6 wk after discharge, and group 5 patients had no surgery. The recurrence rates of pancreatitis were calculated for all groups. Forty-eight patients with gallstone pancreatitis were identified in this study. The 19 patients in group 1 had no recurrence of their pancreatitis. Of the remaining 29 patients, nine (31%) had recurrence of pancreatitis or required readmission for abdominal pain prior to their cholecystectomy. In group 2, two of the eight patients (25%) had recurrent pancreatitis. In group 3, three of eight patients (37.5%) developed recurrent pancreatitis. In group 4, three of five patients (60%), and in group 5, one of eight. No children in group 5 had demonstrable gallstones at presentation, only sludge in their gallbladder. Cholecystectomy during the index admission is associated with no recurrence or readmission for pancreatitis. Therefore, we recommend that cholecystectomy be performed after resolution of an episode of gallstone pancreatitis during index admission. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. DETERMINANTS OF LEISURE-TIME PHYSICAL ACTIVITY: EVIDENCE FROM MALAYSIA

    OpenAIRE

    YONG KANG CHEAH; ANDREW K. G. TAN

    2014-01-01

    This paper examines how socio-demographic and health-lifestyle factors determine participation and duration of leisure-time physical activity in Malaysia. Based on the Malaysia Non-Communicable Disease Surveillance-1 data, Heckman's sample selection model is employed to estimate the probability to participate and duration on physical activity. Results indicate that gender, age, years of education and family illness history are significant in explaining participation probability in leisure-tim...

  2. DETERMINATION ОF DRESS ROLL OPTIMAL RADIUS WHILE PRODUCING PARTS WITH TROCHOIDAL PROFILE

    Directory of Open Access Journals (Sweden)

    E. N. Yankevich

    2008-01-01

    Full Text Available The paper considers determination of the dress roll optimal radius while producing parts having trohoidal profile with the help of grinding method that presupposes application of grinding disk. In this case disk profile has been cut-in by diamond dressing. Two methods for determination of calculation of the dress roll optimal radius have been proposed in the paper. On the basis of the satellite gear of the planetary pin reducer whose profile presents a trochoid it has been shown that the obtained results pertaining to two proposed methods conform with each other.

  3. Iteration particle swarm optimization for contract capacities selection of time-of-use rates industrial customers

    International Nuclear Information System (INIS)

    Lee, Tsung-Ying; Chen, Chun-Lung

    2007-01-01

    This paper presents a new algorithm for solving the optimal contract capacities of a time-of-use (TOU) rates industrial customer. This algorithm is named iteration particle swarm optimization (IPSO). A new index, called iteration best is incorporated into particle swarm optimization (PSO) to improve solution quality and computation efficiency. Expanding line construction cost and contract recovery cost are considered, as well as demand contract capacity cost and penalty bill, in the selection of the optimal contract capacities. The resulting optimal contract capacity effectively reaches the minimum electricity charge of TOU rates users. A significant reduction in electricity costs is observed. The effects of expanding line construction cost and contract recovery cost on the selection of optimal contract capacities can also be estimated. The feasibility of the new algorithm is demonstrated by a numerical example, and the IPSO solution quality and computation efficiency are compared to those of other algorithms

  4. Optimal methods for fitting probability distributions to propagule retention time in studies of zoochorous dispersal.

    Science.gov (United States)

    Viana, Duarte S; Santamaría, Luis; Figuerola, Jordi

    2016-02-01

    Propagule retention time is a key factor in determining propagule dispersal distance and the shape of "seed shadows". Propagules dispersed by animal vectors are either ingested and retained in the gut until defecation or attached externally to the body until detachment. Retention time is a continuous variable, but it is commonly measured at discrete time points, according to pre-established sampling time-intervals. Although parametric continuous distributions have been widely fitted to these interval-censored data, the performance of different fitting methods has not been evaluated. To investigate the performance of five different fitting methods, we fitted parametric probability distributions to typical discretized retention-time data with known distribution using as data-points either the lower, mid or upper bounds of sampling intervals, as well as the cumulative distribution of observed values (using either maximum likelihood or non-linear least squares for parameter estimation); then compared the estimated and original distributions to assess the accuracy of each method. We also assessed the robustness of these methods to variations in the sampling procedure (sample size and length of sampling time-intervals). Fittings to the cumulative distribution performed better for all types of parametric distributions (lognormal, gamma and Weibull distributions) and were more robust to variations in sample size and sampling time-intervals. These estimated distributions had negligible deviations of up to 0.045 in cumulative probability of retention times (according to the Kolmogorov-Smirnov statistic) in relation to original distributions from which propagule retention time was simulated, supporting the overall accuracy of this fitting method. In contrast, fitting the sampling-interval bounds resulted in greater deviations that ranged from 0.058 to 0.273 in cumulative probability of retention times, which may introduce considerable biases in parameter estimates. We

  5. Time Reversal Reconstruction Algorithm Based on PSO Optimized SVM Interpolation for Photoacoustic Imaging

    Directory of Open Access Journals (Sweden)

    Mingjian Sun

    2015-01-01

    Full Text Available Photoacoustic imaging is an innovative imaging technique to image biomedical tissues. The time reversal reconstruction algorithm in which a numerical model of the acoustic forward problem is run backwards in time is widely used. In the paper, a time reversal reconstruction algorithm based on particle swarm optimization (PSO optimized support vector machine (SVM interpolation method is proposed for photoacoustics imaging. Numerical results show that the reconstructed images of the proposed algorithm are more accurate than those of the nearest neighbor interpolation, linear interpolation, and cubic convolution interpolation based time reversal algorithm, which can provide higher imaging quality by using significantly fewer measurement positions or scanning times.

  6. A Self-Adaptive Fuzzy c-Means Algorithm for Determining the Optimal Number of Clusters

    Science.gov (United States)

    Wang, Zhihao; Yi, Jing

    2016-01-01

    For the shortcoming of fuzzy c-means algorithm (FCM) needing to know the number of clusters in advance, this paper proposed a new self-adaptive method to determine the optimal number of clusters. Firstly, a density-based algorithm was put forward. The algorithm, according to the characteristics of the dataset, automatically determined the possible maximum number of clusters instead of using the empirical rule n and obtained the optimal initial cluster centroids, improving the limitation of FCM that randomly selected cluster centroids lead the convergence result to the local minimum. Secondly, this paper, by introducing a penalty function, proposed a new fuzzy clustering validity index based on fuzzy compactness and separation, which ensured that when the number of clusters verged on that of objects in the dataset, the value of clustering validity index did not monotonically decrease and was close to zero, so that the optimal number of clusters lost robustness and decision function. Then, based on these studies, a self-adaptive FCM algorithm was put forward to estimate the optimal number of clusters by the iterative trial-and-error process. At last, experiments were done on the UCI, KDD Cup 1999, and synthetic datasets, which showed that the method not only effectively determined the optimal number of clusters, but also reduced the iteration of FCM with the stable clustering result. PMID:28042291

  7. Optimization and real-time control for laser treatment of heterogeneous soft tissues.

    Science.gov (United States)

    Feng, Yusheng; Fuentes, David; Hawkins, Andrea; Bass, Jon M; Rylander, Marissa Nichole

    2009-01-01

    Predicting the outcome of thermotherapies in cancer treatment requires an accurate characterization of the bioheat transfer processes in soft tissues. Due to the biological and structural complexity of tumor (soft tissue) composition and vasculature, it is often very difficult to obtain reliable tissue properties that is one of the key factors for the accurate treatment outcome prediction. Efficient algorithms employing in vivo thermal measurements to determine heterogeneous thermal tissues properties in conjunction with a detailed sensitivity analysis can produce essential information for model development and optimal control. The goals of this paper are to present a general formulation of the bioheat transfer equation for heterogeneous soft tissues, review models and algorithms developed for cell damage, heat shock proteins, and soft tissues with nanoparticle inclusion, and demonstrate an overall computational strategy for developing a laser treatment framework with the ability to perform real-time robust calibrations and optimal control. This computational strategy can be applied to other thermotherapies using the heat source such as radio frequency or high intensity focused ultrasound.

  8. The optimal production-run time for a stock-dependent imperfect production process

    Directory of Open Access Journals (Sweden)

    Jain Divya

    2013-01-01

    Full Text Available This paper develops an inventory model for a hypothesized volume flexible manufacturing system in which the production rate is stock-dependent and the system produces both perfect and imperfect quality items. The demand rate of perfect quality items is known and constant, whereas the demand rate of imperfect (non-conforming to specifications quality items is a function of discount offered in the selling price. In this paper, we determine an optimal production-run time and the optimal discount that should be offered in the selling price to influence the sale of imperfect quality items produced by the manufacturing system. The considered model aims to maximize the net profit obtained through the sales of both perfect and imperfect quality items subject to certain constraints of the system. The solution procedure suggests the use of ‘Interior Penalty Function Method’ to solve the associated constrained maximization problem. Finally, a numerical example demonstrating the applicability of proposed model has been included.

  9. Optimization aspects of the ARAC real-time radiological emergency response system

    International Nuclear Information System (INIS)

    Taylor, S.S.; Sullivan, T.J.

    1985-07-01

    The Atmospheric Release Advisory Capability (ARAC) project at the Lawrence Livermore National Laboratory responds to radiological emergencies throughout the Continental United States. Using complex three-dimensional dispersion models to account for the effects of complex meteorology and regional terrain, ARAC simulates the release of radioactive materials and provides dispersion, deposition, and dose calculations that are displayed over local geographic features for use by authorities at the accident/release site. ARAC's response is ensured by a software system that (1) makes optimal use of dispersion models, (2) minimizes the time required to provide projections, and (3) maximizes the fault-tolerance of the system. In this paper we describe ARAC's goals and functionality and the costs associated with its development and use. Specifically, we address optimizations in ARAC notifications, meteorological data collection, the determination of site- and problem-specific parameters, the generation of site-specific topography and geography, the running of models, and the distribution of ARAC products. We also discuss the backup features employed to ensure ARAC's ability to respond

  10. Worst-Case Execution Time Based Optimization of Real-Time Java Programs

    DEFF Research Database (Denmark)

    Hepp, Stefan; Schoeberl, Martin

    2012-01-01

    optimization is method in lining. It is especially important for languages, like Java, where small setter and getter methods are considered good programming style. In this paper we present and explore WCET driven in lining of Java methods. We use the WCET analysis tool for the Java processor JOP to guide...

  11. Optimal timing of coronary invasive strategy in non-ST-segment elevation acute coronary syndromes

    DEFF Research Database (Denmark)

    Navarese, Eliano P; Gurbel, Paul A; Andreotti, Felicita

    2013-01-01

    The optimal timing of coronary intervention in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACSs) is a matter of debate. Conflicting results among published studies partly relate to different risk profiles of the studied populations.......The optimal timing of coronary intervention in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACSs) is a matter of debate. Conflicting results among published studies partly relate to different risk profiles of the studied populations....

  12. Optimization of a radiochemistry method for plutonium determination in biological samples

    International Nuclear Information System (INIS)

    Cerchetti, Maria L.; Arguelles, Maria G.

    2005-01-01

    Plutonium has been widely used for civilian an military activities. Nevertheless, the methods to control work exposition have not evolved in the same way, remaining as one of the major challengers for the radiological protection practice. Due to the low acceptable incorporation limit, the usual determination is based on indirect methods in urine samples. Our main objective was to optimize a technique used to monitor internal contamination of workers exposed to Plutonium isotopes. Different parameters were modified and their influence on the three steps of the method was evaluated. Those which gave the highest yield and feasibility were selected. The method involves: 1-) Sample concentration (coprecipitation); 2-) Plutonium purification; and 3-) Source preparation by electrodeposition. On the coprecipitation phase, changes on temperature and concentration of the carrier were evaluated. On the ion-exchange separation, changes on the type of the resin, elution solution for hydroxylamine (concentration and volume), length and column recycle were evaluated. Finally, on the electrodeposition phase, we modified the following: electrolytic solution, pH and time. Measures were made by liquid scintillation counting and alpha spectrometry (PIPS). We obtained the following yields: 88% for coprecipitation (at 60 C degree with 2 ml of CaHPO 4 ), 71% for ion-exchange (resins AG 1x8 Cl - 100-200 mesh, hydroxylamine 0.1N in HCl 0.2N as eluent, column between 4.5 and 8 cm), and 93% for electrodeposition (H 2 SO 4 -NH 4 OH, 100 minutes and pH from 2 to 2.8). The expand uncertainty was 30% (NC 95%), the decision threshold (Lc) was 0.102 Bq/L and the minimum detectable activity was 0.218 Bq/L of urine. We obtained an optimized method to screen workers exposed to Plutonium. (author)

  13. HIV Treatment and Prevention: A Simple Model to Determine Optimal Investment.

    Science.gov (United States)

    Juusola, Jessie L; Brandeau, Margaret L

    2016-04-01

    To create a simple model to help public health decision makers determine how to best invest limited resources in HIV treatment scale-up and prevention. A linear model was developed for determining the optimal mix of investment in HIV treatment and prevention, given a fixed budget. The model incorporates estimates of secondary health benefits accruing from HIV treatment and prevention and allows for diseconomies of scale in program costs and subadditive benefits from concurrent program implementation. Data sources were published literature. The target population was individuals infected with HIV or at risk of acquiring it. Illustrative examples of interventions include preexposure prophylaxis (PrEP), community-based education (CBE), and antiretroviral therapy (ART) for men who have sex with men (MSM) in the US. Outcome measures were incremental cost, quality-adjusted life-years gained, and HIV infections averted. Base case analysis indicated that it is optimal to invest in ART before PrEP and to invest in CBE before scaling up ART. Diseconomies of scale reduced the optimal investment level. Subadditivity of benefits did not affect the optimal allocation for relatively low implementation levels. The sensitivity analysis indicated that investment in ART before PrEP was optimal in all scenarios tested. Investment in ART before CBE became optimal when CBE reduced risky behavior by 4% or less. Limitations of the study are that dynamic effects are approximated with a static model. Our model provides a simple yet accurate means of determining optimal investment in HIV prevention and treatment. For MSM in the US, HIV control funds should be prioritized on inexpensive, effective programs like CBE, then on ART scale-up, with only minimal investment in PrEP. © The Author(s) 2015.

  14. Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pelgrim, G.J., E-mail: g.j.pelgrim@umcg.nl [University of Groningen, University Medical Center Groningen, Center for Medical Imaging North East Netherlands (CMI-nen), Hanzeplein 1, 9713 GZ Groningen (Netherlands); Nieuwenhuis, E.R., E-mail: e.r.nieuwenhuis@student.utwente.nl [University of Groningen, University Medical Center Groningen, Center for Medical Imaging North East Netherlands (CMI-nen), Hanzeplein 1, 9713 GZ Groningen (Netherlands); University of Twente, P.O. Box 217, 7500 AE, Enschede (Netherlands); Duguay, T.M., E-mail: duguay@musc.edu [Medical University of South Carolina, Dept. of Radiology, 25 Courtenay Drive, SC 29425, Charleston (United States); Geest, R.J. van der, E-mail: R.J.van_der_Geest@lumc.nl [Leiden University Medical Center, Dept. of Radiology, Postbus 9600, 2300 RC, Leiden (Netherlands); Varga-Szemes, A., E-mail: vargaasz@musc.edu [Medical University of South Carolina, Dept. of Radiology, 25 Courtenay Drive, SC 29425, Charleston (United States); Slump, C.H., E-mail: c.h.slump@utwente.nl [University of Groningen, University Medical Center Groningen, Center for Medical Imaging North East Netherlands (CMI-nen), Hanzeplein 1, 9713 GZ Groningen (Netherlands); University of Twente, P.O. Box 217, 7500 AE, Enschede (Netherlands); Fuller, S.R., E-mail: fullerst@musc.edu [Medical University of South Carolina, Dept. of Radiology, 25 Courtenay Drive, SC 29425, Charleston (United States); Oudkerk, M., E-mail: m.oudkerk@umcg.nl [University of Groningen, University Medical Center Groningen, Center for Medical Imaging North East Netherlands (CMI-nen), Hanzeplein 1, 9713 GZ Groningen (Netherlands); Schoepf, U.J., E-mail: schoepf@musc.edu [Medical University of South Carolina, Dept. of Radiology, 25 Courtenay Drive, SC 29425, Charleston (United States); and others

    2017-01-15

    Highlights: • Optimal timing of static, single-shot CT perfusion scans is important to differentiate ischemic from non-ischemic myocardial segments. • Time delay between reaching 150 and 250 HU thresholds in the ascending aorta and optimal contrast in the myocardium are 4 and 2 s, respectively. • Attenuation difference of more than 15 HU between normal and ischemic myocardium is present during approximately 8 s. - Abstract: Purpose: To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. Methods and materials: Twenty-five patients (59 ± 8.4 years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30 s at 100 kV and 300 mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments. The left ventricle (LV) wall was manually segmented according to the AHA 16-segment model. Hounsfield units (HU) in myocardial segments and ascending (AA) and descending aorta (AD) were monitored over time. Time difference between peak AA and peak AD and peak myocardial enhancement was calculated, as well as the, time delay from fixed HU thresholds of 150 and 250 HU in the AA and AD to a minimal difference of 15 HU between normal and ischemic segments. Furthermore, the duration of the 15 HU difference between ischemic and non-ischemic segments was calculated. Results: Myocardial ischemia was observed by MRI in 10 patients (56.3 ± 9.0 years; 8 male). The delay between the maximum HU in the AA and AD and maximal HU in the non-ischemic segments was 2.8 s [2.2–4.3] and 0.0 s [0.0–2.8], respectively. Differentiation between ischemic and non-ischemic myocardial segments in CT was best during a time window of 8.6 ± 3.8 s. Time delays for AA triggering were 4.5 s [2.2–5.6] and 2.2 s [0–2.8] for the 150 HU and 250 HU thresholds, respectively. While for

  15. Time poverty in Brazil: measurement and analysis of its determinants

    Directory of Open Access Journals (Sweden)

    Lilian Lopes Ribeiro

    2012-06-01

    Full Text Available This article analyzes well-being on an individual level, through the allocation of work hours done by adults and children and thus it measures time poverty in Brazil. In order to achieve such measurement, poverty indicators such as Foster, Greer and Thorbecke (FGT were adapted into a time poverty mode. Additionally, an analysis of its determinants was also conducted. Among other findings, the fact that women (either children and adult ones are the time-poorest individuals in urban or rural areas. Another unfortunate finding is that the high rate of time poverty among children, numerically 16,1% is not far from the adult rate which is of 19,7%. The overall composite time poor individual profile is of an African-Brazilian adult woman of little education, not necessarily income poor and residing in an urban area of the northeast region, living in a household of few people, she is the mother of children who are younger than 14 years old.

  16. Optimal the tilt angles for photovoltaic modules using PSO method with nonlinear time-varying evolution

    International Nuclear Information System (INIS)

    Chang, Ying-Pin

    2010-01-01

    A particle-swarm optimization method with nonlinear time-varying evolution (PSO-NTVE) is employed in determining the tilt angle of photovoltaic (PV) modules in Taiwan. The objective is to maximize the output electrical energy of the modules. In this study, seven Taiwanese cities were selected for analysis. First, the sun's position at any time and location was predicted by the mathematical procedure of Julian dating, and then the solar irradiation was obtained at each site under a clear sky. By combining the temperature effect, the PSO-NTVE method is adopted to calculate the optimal tilt angles for fixed south-facing PV modules. In this method, the parameters are determined by using matrix experiments with an orthogonal array, in which a minimal number of experiments have an effect that approximates the full factorial experiments. Statistical error analysis was performed to compare the results between the four PSO methods and experimental results. Hengchun city in which the minimum total error value of 6.12% the reasons for the weather more stability and less building shade. A comparison of the measurement results in electrical energy between the four PSO methods and the PV modules set a six tilt angles. Obviously four types of PSO methods simulation of electrical energy value from 231.12 kWh/m 2 for Taipei to 233.81 kWh/m 2 for Hengchun greater than the measurement values from 224.71 kWh/m 2 for Taichung to 228.47 kWh/m 2 for Hengchun by PV module which is due to instability caused by climate change. Finally, the results show that the annual optimal angle for the Taipei area is 18.16 o ; for Taichung, 17.3 o ; for Tainan, 16.15 o ; for Kaosiung, 15.79 o ; for Hengchung, 15.17 o ; for Hualian, 17.16 o ; and for Taitung, 15.94 o . It is evident that the authorized Industrial Technology Research Institute (ITRI) recommends that tilt angle of 23.5 o was not an appropriate use of Taiwan's seven cities. PV modules with the installation of the tilt angle should be

  17. Determination and optimization of the ζ potential in boron electrophoretic deposition on aluminium substrates

    International Nuclear Information System (INIS)

    Oliveira Sampa, M.H. de; Vinhas, L.A.; Pino, E.S.

    1991-05-01

    In this work we present an introduction of the electrophoretic process followed by a detailed experimental treatment of the technique used in the determination and optimization of the ζ-potential, mainly as a function of the electrolyte concentration, in a high purity boron electrophoretics deposition on aluminium substrates used as electrodes in neutron detectors. (author)

  18. Optimization in Activation Analysis by Means of Epithermal Neutrons. Determination of Molybdenum in Steel

    Energy Technology Data Exchange (ETDEWEB)

    Brune, D; Jirlow, J

    1963-12-15

    Optimization in activation analysis by means of selective activation with epithermal neutrons is discussed. This method was applied to the determination of molybdenum in a steel alloy without recourse to radiochemical separations. The sensitivity for this determination is estimated to be 10 ppm. With the common form of activation by means of thermal neutrons, the sensitivity would be about one-tenth of this. The sensitivity estimations are based on evaluation of the photo peak ratios of Mo-99/Fe-59.

  19. Cycle Time Optimization of Chamomile Package 120 MI Product at Blow Molding Process

    Directory of Open Access Journals (Sweden)

    Yuni Hermawan

    2012-11-01

    Full Text Available Chamomile is a package which is applied for cosmetic. In industry this package is being processed by blow molding. Thereare many parameters that influence cycle time during production; in this project only three of them were varied, i.e. blowingpressure, blowing time and stopping time. Each parameter is determined three chosen level. Middle level is taken fromstandard setting of machining which is being used by industry. Top and bottom level is randomized. Three stopping time are0.1, 0.55, and 1.0 second. Blowing time are 10.5, 11.5 and 12.5 second. Where as, blowing pressures is 4, 5 and 6 bar.Combination of among levels is based on Box Behnken design. Those three parameters are called variable process. In theother hand, variable responses are cycle time and net weight. Each combination is replicated 5 times and then averaged. Thedata then is processed by using Minitab version 14th. Square regression of the model for cycle time is ?CT = 21,1300 - 0,0912X1 + 0,2000 X2 + 0,6313 X3 + 0,6100 X12 + 0,6975 X22 – 0,1000 X1 X2 – 0,1725 X1 X3 + 0,1100 X2 X3 and Net = 19,2933 –0,0088 X1 + 0,0175 X2 + 0,0712 X3 + 0,0133 X 21 + 0.0158 X22- 0.0217 X 23 + 0.0125 X1X2 - 0,0150 X1 X3 for product netweight. Where X1 is blowing pressure, X2 is blowing time and X3 is stopping time.The model developed then tested by lack offit testing, variance by ANOVA and R square. Second stage of model testing is residual test. Three tests are carry out, i.e.identically test and independency test and normality. Optimization of both values, cycle time and net weight, are searched byResponse Surface Method. By the method it is found that the optimum condition of cycle time is 20.5 seconds and net weightis 19.19 grams. The optimum condition is achieved when stopping is 0.1 second, blowing time 11.35 second and blowingpressure 5.1 bars.

  20. Real-time SPARSE-SENSE cardiac cine MR imaging: optimization of image reconstruction and sequence validation.

    Science.gov (United States)

    Goebel, Juliane; Nensa, Felix; Bomas, Bettina; Schemuth, Haemi P; Maderwald, Stefan; Gratz, Marcel; Quick, Harald H; Schlosser, Thomas; Nassenstein, Kai

    2016-12-01

    Improved real-time cardiac magnetic resonance (CMR) sequences have currently been introduced, but so far only limited practical experience exists. This study aimed at image reconstruction optimization and clinical validation of a new highly accelerated real-time cine SPARSE-SENSE sequence. Left ventricular (LV) short-axis stacks of a real-time free-breathing SPARSE-SENSE sequence with high spatiotemporal resolution and of a standard segmented cine SSFP sequence were acquired at 1.5 T in 11 volunteers and 15 patients. To determine the optimal iterations, all volunteers' SPARSE-SENSE images were reconstructed using 10-200 iterations, and contrast ratios, image entropies, and reconstruction times were assessed. Subsequently, the patients' SPARSE-SENSE images were reconstructed with the clinically optimal iterations. LV volumetric values were evaluated and compared between both sequences. Sufficient image quality and acceptable reconstruction times were achieved when using 80 iterations. Bland-Altman plots and Passing-Bablok regression showed good agreement for all volumetric parameters. 80 iterations are recommended for iterative SPARSE-SENSE image reconstruction in clinical routine. Real-time cine SPARSE-SENSE yielded comparable volumetric results as the current standard SSFP sequence. Due to its intrinsic low image acquisition times, real-time cine SPARSE-SENSE imaging with iterative image reconstruction seems to be an attractive alternative for LV function analysis. • A highly accelerated real-time CMR sequence using SPARSE-SENSE was evaluated. • SPARSE-SENSE allows free breathing in real-time cardiac cine imaging. • For clinically optimal SPARSE-SENSE image reconstruction, 80 iterations are recommended. • Real-time SPARSE-SENSE imaging yielded comparable volumetric results as the reference SSFP sequence. • The fast SPARSE-SENSE sequence is an attractive alternative to standard SSFP sequences.

  1. On the complexity of determining tolerances for ->e--optimal solutions to min-max combinatorial optimization problems

    NARCIS (Netherlands)

    Ghosh, D.; Sierksma, G.

    2000-01-01

    Sensitivity analysis of e-optimal solutions is the problem of calculating the range within which a problem parameter may lie so that the given solution re-mains e-optimal. In this paper we study the sensitivity analysis problem for e-optimal solutions tocombinatorial optimization problems with

  2. The time optimal trajectory planning with limitation of operating task for the Tokamak inspecting manipulator

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hesheng; Lai, Yinping [Department of Automation,Shanghai Jiao Tong University, Shanghai (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Chen, Weidong, E-mail: wdchen@sjtu.edu.cn [Department of Automation,Shanghai Jiao Tong University, Shanghai (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China (China)

    2016-12-15

    In this paper, a new optimization model of time optimal trajectory planning with limitation of operating task for the Tokamak inspecting manipulator is designed. The task of this manipulator is to inspect the components of Tokamak, the inspecting velocity of manipulator must be limited in the operating space in order to get the clear pictures. With the limitation of joint velocity, acceleration and jerk, this optimization model can not only get the minimum working time along a specific path, but also ensure the imaging quality of camera through the constraint of inspecting velocity. The upper bound of the scanning speed is not a constant but changes according to the observation distance of camera in real time. The relation between scanning velocity and observation distance is estimated by curve-fitting. Experiment has been carried out to verify the feasibility of optimization model, moreover, the Laplace image sharpness evaluation method is adopted to evaluate the quality of images obtained by the proposed method.

  3. The time optimal trajectory planning with limitation of operating task for the Tokamak inspecting manipulator

    International Nuclear Information System (INIS)

    Wang, Hesheng; Lai, Yinping; Chen, Weidong

    2016-01-01

    In this paper, a new optimization model of time optimal trajectory planning with limitation of operating task for the Tokamak inspecting manipulator is designed. The task of this manipulator is to inspect the components of Tokamak, the inspecting velocity of manipulator must be limited in the operating space in order to get the clear pictures. With the limitation of joint velocity, acceleration and jerk, this optimization model can not only get the minimum working time along a specific path, but also ensure the imaging quality of camera through the constraint of inspecting velocity. The upper bound of the scanning speed is not a constant but changes according to the observation distance of camera in real time. The relation between scanning velocity and observation distance is estimated by curve-fitting. Experiment has been carried out to verify the feasibility of optimization model, moreover, the Laplace image sharpness evaluation method is adopted to evaluate the quality of images obtained by the proposed method.

  4. Optimized and validated high-performance liquid chromatography method for the determination of deoxynivalenol and aflatoxins in cereals.

    Science.gov (United States)

    Skendi, Adriana; Irakli, Maria N; Papageorgiou, Maria D

    2016-04-01

    A simple, sensitive and accurate analytical method was optimized and developed for the determination of deoxynivalenol and aflatoxins in cereals intended for human consumption using high-performance liquid chromatography with diode array and fluorescence detection and a photochemical reactor for enhanced detection. A response surface methodology, using a fractional central composite design, was carried out for optimization of the water percentage at the beginning of the run (X1, 80-90%), the level of acetonitrile at the end of gradient system (X2, 10-20%) with the water percentage fixed at 60%, and the flow rate (X3, 0.8-1.2 mL/min). The studied responses were the chromatographic peak area, the resolution factor and the time of analysis. Optimal chromatographic conditions were: X1 = 80%, X2 = 10%, and X3 = 1 mL/min. Following a double sample extraction with water and a mixture of methanol/water, mycotoxins were rapidly purified by an optimized solid-phase extraction protocol. The optimized method was further validated with respect to linearity (R(2) >0.9991), sensitivity, precision, and recovery (90-112%). The application to 23 commercial cereal samples from Greece showed contamination levels below the legally set limits, except for one maize sample. The main advantages of the developed method are the simplicity of operation and the low cost. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Continuous and Discrete-Time Optimal Controls for an Isolated Signalized Intersection

    Directory of Open Access Journals (Sweden)

    Jiyuan Tan

    2017-01-01

    Full Text Available A classical control problem for an isolated oversaturated intersection is revisited with a focus on the optimal control policy to minimize total delay. The difference and connection between existing continuous-time planning models and recently proposed discrete-time planning models are studied. A gradient descent algorithm is proposed to convert the optimal control plan of the continuous-time model to the plan of the discrete-time model in many cases. Analytic proof and numerical tests for the algorithm are also presented. The findings shed light on the links between two kinds of models.

  6. Optimizing Time Windows For Managing Export Container Arrivals At Chinese Container Terminals

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen

    2010-01-01

    window management programme that is widely used in Chinese terminals to facilitate terminal and truck delivery operations. Firstly, the arrangement of time windows is assumed to follow the principle of minimizing transport costs. A cost function is defined that includes the costs of truck and driver...... waiting time, fuel consumption associated with truck idling, storage time of the containerized cargos and yard fee. Secondly, to minimize the total cost, a heuristic is developed based on a genetic algorithm to find a near optimal time window arrangement. The optimized solution involves the position...

  7. OPTIMIZING TIME WINDOWS FOR MANAGING ARRIVALS OF EXPORT CONTAINERS AT CHINESE CONTAINER TERMINALS

    DEFF Research Database (Denmark)

    Chen, Gang; Yang, Zhongzhen

    2009-01-01

    of driver and truck waiting time, the cost of container cargo storage time, the truck idle cost and terminal yard fee. Secondly, to minimize the costs, a heuristic is developed based on a genetic algorithm to optimize the time window arrangement. The optimal solution involves the position and the length...... window management programme that is widely used in Chinese terminals to facilitate the terminal operations and the truck delivery operations. Firstly, the arrangement of time windows is assumed to follow the principle of minimizing the transport costs. A cost function is defined that includes the cost...

  8. Determining optimum aging time using novel core flooding equipment

    DEFF Research Database (Denmark)

    Ahkami, Mehrdad; Chakravarty, Krishna Hara; Xiarchos, Ioannis

    2016-01-01

    the optimum aging time regardless of variations in crude oil, rock, and brine properties. State of the art core flooding equipment has been developed that can be used for consistently determining the resistivity of the coreplug during aging and waterflooding using advanced data acquisition software......New methods for enhanced oil recovery are typically developed using core flooding techniques. Establishing reservoir conditions is essential before the experimental campaign commences. The realistic oil-rock wettability can be obtained through optimum aging of the core. Aging time is affected....... In the proposed equipment, independent axial and sleeve pressure can be applied to mimic stresses at reservoir conditions. 10 coreplugs (four sandstones and six chalk samples) from the North Sea have been aged for more than 408 days in total and more than 29000 resistivity data points have been measured...

  9. METHODOLOGY FOR DETERMINING OPTIMAL EXPOSURE PARAMETERS OF A HYPERSPECTRAL SCANNING SENSOR

    Directory of Open Access Journals (Sweden)

    P. Walczykowski

    2016-06-01

    Full Text Available The purpose of the presented research was to establish a methodology that would allow the registration of hyperspectral images with a defined spatial resolution on a horizontal plane. The results obtained within this research could then be used to establish the optimum sensor and flight parameters for collecting aerial imagery data using an UAV or other aerial system. The methodology is based on an user-selected optimal camera exposure parameters (i.e. time, gain value and flight parameters (i.e. altitude, velocity. A push-broom hyperspectral imager- the Headwall MicroHyperspec A-series VNIR was used to conduct this research. The measurement station consisted of the following equipment: a hyperspectral camera MicroHyperspec A-series VNIR, a personal computer with HyperSpec III software, a slider system which guaranteed the stable motion of the sensor system, a white reference panel and a Siemens star, which was used to evaluate the spatial resolution. Hyperspectral images were recorded at different distances between the sensor and the target- from 5m to 100m. During the registration process of each acquired image, many exposure parameters were changed, such as: the aperture value, exposure time and speed of the camera’s movement on the slider. Based on all of the registered hyperspectral images, some dependencies between chosen parameters had been developed: - the Ground Sampling Distance – GSD and the distance between the sensor and the target, - the speed of the camera and the distance between the sensor and the target, - the exposure time and the gain value, - the Density Number and the gain value. The developed methodology allowed us to determine the speed and the altitude of an unmanned aerial vehicle on which the sensor would be mounted, ensuring that the registered hyperspectral images have the required spatial resolution.

  10. Experimental investigation for determination of optimal X-ray beam tube voltages in a newly developed digital breast tomosynthesis system

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye-Suk, E-mail: radiosugar@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Ye-Seul, E-mail: radiohesugar@gmail.com [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Choi, Young-Wook, E-mail: ywchoi@keri.re.kr [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Choi, JaeGu, E-mail: jgchoi88@paran.com [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Rhee, Yong-Chun, E-mail: ycrhee@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Hee-Joung, E-mail: hjk1@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of)

    2014-11-01

    Our purpose was to investigate optimal tube voltages (kVp) for a newly developed digital breast tomosynthesis (DBT) process and to determine tube current–exposure time products (mA s) for the average glandular dose (AGD), which is similar to that of the two views in conventional mammography (CM). In addition, the optimal acquisition parameters for this system were compared with those of CM. The analysis was based on the contrast-to-noise ratio (CNR) from the simulated micro-calcifications on homogeneous phantoms, and the figure of merit (FOM) was retrieved from the CNR and AGD at X-ray tube voltages ranging from 24 to 40 kVp at intervals of 2 kV. The optimal kVp increased more than 2 kV with increasing glandularity for thicker (≥50 mm) breast phantoms. The optimal kVp for DBT was found to be 4–7 kV higher than that calculated for CM with breast phantoms thicker than 50 mm. This is likely due to the greater effect of noise and dose reduction by kVp increment when using the lower dose per projection in DBT. It is important to determine optimum acquisition conditions for a maximally effective DBT system. The results of our study provide useful information to further improve DBT for high quality imaging.

  11. Optimal timing for early surgery in infective endocarditis: a meta-analysis†

    Science.gov (United States)

    Liang, Fuxiang; Song, Bing; Liu, Ruisheng; Yang, Liu; Tang, Hanbo; Li, Yuanming

    2016-01-01

    required to clarify the optimal timing for surgical intervention and determine its efficacy in PVE. PMID:26678152

  12. Optimal timing for early surgery in infective endocarditis: a meta-analysis.

    Science.gov (United States)

    Liang, Fuxiang; Song, Bing; Liu, Ruisheng; Yang, Liu; Tang, Hanbo; Li, Yuanming

    2016-03-01

    trials will be required to clarify the optimal timing for surgical intervention and determine its efficacy in PVE. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  13. Determination of an optimal priming duration and concentration protocol for pepper seeds (Capsicum annuum L.

    Directory of Open Access Journals (Sweden)

    Hassen ALOUI

    2015-12-01

    Full Text Available Seed priming is a simple pre-germination method to improve seed performance and to attenuate the effects of stress exposure. The objective of this study was to determinate an optimal priming protocol for three pepper cultivars (Capsicum annuum L.: ‘Beldi’, ‘Baklouti’ and ‘Anaheim Chili’. Seeds were primed with three solutions of NaCl, KCl and CaCl2 (0, 10, 20 and 50 mM for three different durations (12, 24 and 36h. Control seeds were soaked in distilled water for the same durations. After that, all seeds were kept to germinate in laboratory under normal light and controlled temperature. Results indicated that priming depends on concentration, duration and cultivar. The best combinations that we obtained were: KCl priming (10 mM, 36h for ‘Beldi’ cultivar, CaCl2 priming (10 mM, 36h for ‘Baklouti’ cultivar and finally NaCl priming (50 mM, 24h for ‘Anaheim Chili’ cultivar. Generally, priming had an effect on total germination percentage, mean germination time, germination index and the coefficient of velocity compared to control seeds. The beneficial effect of seed priming could be used for improving salt tolerance on germination and early seedling growth for pepper cultivar.

  14. Optimal control of switching time in switched stochastic systems with multi-switching times and different costs

    Science.gov (United States)

    Liu, Xiaomei; Li, Shengtao; Zhang, Kanjian

    2017-08-01

    In this paper, we solve an optimal control problem for a class of time-invariant switched stochastic systems with multi-switching times, where the objective is to minimise a cost functional with different costs defined on the states. In particular, we focus on problems in which a pre-specified sequence of active subsystems is given and the switching times are the only control variables. Based on the calculus of variation, we derive the gradient of the cost functional with respect to the switching times on an especially simple form, which can be directly used in gradient descent algorithms to locate the optimal switching instants. Finally, a numerical example is given, highlighting the validity of the proposed methodology.

  15. A New Method for Determining Optimal Regularization Parameter in Near-Field Acoustic Holography

    Directory of Open Access Journals (Sweden)

    Yue Xiao

    2018-01-01

    Full Text Available Tikhonov regularization method is effective in stabilizing reconstruction process of the near-field acoustic holography (NAH based on the equivalent source method (ESM, and the selection of the optimal regularization parameter is a key problem that determines the regularization effect. In this work, a new method for determining the optimal regularization parameter is proposed. The transfer matrix relating the source strengths of the equivalent sources to the measured pressures on the hologram surface is augmented by adding a fictitious point source with zero strength. The minimization of the norm of this fictitious point source strength is as the criterion for choosing the optimal regularization parameter since the reconstructed value should tend to zero. The original inverse problem in calculating the source strengths is converted into a univariate optimization problem which is solved by a one-dimensional search technique. Two numerical simulations with a point driven simply supported plate and a pulsating sphere are investigated to validate the performance of the proposed method by comparison with the L-curve method. The results demonstrate that the proposed method can determine the regularization parameter correctly and effectively for the reconstruction in NAH.

  16. Determination of optimal electrode positions for transcranial direct current stimulation (tDCS)

    International Nuclear Information System (INIS)

    Im, Chang-Hwan; Jung, Hui-Hun; Choi, Jung-Do; Lee, Soo Yeol; Jung, Ki-Young

    2008-01-01

    The present study introduces a new approach to determining optimal electrode positions in transcranial direct current stimulation (tDCS). Electric field and 3D conduction current density were analyzed using 3D finite element method (FEM) formulated for a dc conduction problem. The electrode positions for minimal current injection were optimized by changing the Cartesian coordinate system into the spherical coordinate system and applying the (2+6) evolution strategy (ES) algorithm. Preliminary simulation studies applied to a standard three-layer head model demonstrated that the proposed approach is promising in enhancing the performance of tDCS. (note)

  17. Determination of optimal electrode positions for transcranial direct current stimulation (tDCS)

    Energy Technology Data Exchange (ETDEWEB)

    Im, Chang-Hwan; Jung, Hui-Hun; Choi, Jung-Do [Department of Biomedical Engineering, Yonsei University, Wonju, 220-710 (Korea, Republic of); Lee, Soo Yeol [Department of Biomedical Engineering, Kyung Hee University, Suwon (Korea, Republic of); Jung, Ki-Young [Korea University Medical Center, Korea University College of Medicine, Seoul (Korea, Republic of)], E-mail: ich@yonsei.ac.kr

    2008-06-07

    The present study introduces a new approach to determining optimal electrode positions in transcranial direct current stimulation (tDCS). Electric field and 3D conduction current density were analyzed using 3D finite element method (FEM) formulated for a dc conduction problem. The electrode positions for minimal current injection were optimized by changing the Cartesian coordinate system into the spherical coordinate system and applying the (2+6) evolution strategy (ES) algorithm. Preliminary simulation studies applied to a standard three-layer head model demonstrated that the proposed approach is promising in enhancing the performance of tDCS. (note)

  18. Experimental determination of optimal clamping torque for AB-PEM Fuel cell

    Directory of Open Access Journals (Sweden)

    Noor Ul Hassan

    2016-04-01

    Full Text Available Polymer electrolyte Membrane (PEM fuel cell is an electrochemical device producing electricity by the reaction of hydrogen and oxygen without combustion. PEM fuel cell stack is provided with an appropriate clamping torque to prevent leakage of reactant gases and to minimize the contact resistance between gas diffusion media (GDL and bipolar plates. GDL porous structure and gas permeability is directly affected by the compaction pressure which, consequently, drastically change the fuel cell performance. Various efforts were made to determine the optimal compaction pressure and pressure distributions through simulations and experimentation. Lower compaction pressure results in increase of contact resistance and also chances of leakage. On the other hand, higher compaction pressure decreases the contact resistance but also narrows down the diffusion path for mass transfer from gas channels to the catalyst layers, consequently, lowering cell performance. The optimal cell performance is related to the gasket thickness and compression pressure on GDL. Every stack has a unique assembly pressure due to differences in fuel cell components material and stack design. Therefore, there is still need to determine the optimal torque value for getting the optimal cell performance. This study has been carried out in continuation of deve­lopment of Air breathing PEM fuel cell for small Unmanned Aerial Vehicle (UAV application. Compaction pressure at minimum contact resistance was determined and clamping torque value was calcu­la­ted accordingly. Single cell performance tests were performed at five different clamping torque values i.e 0.5, 1.0, 1.5, 2.0 and 2.5 N m, for achieving optimal cell per­formance. Clamping pressure distribution tests were also performed at these torque values to verify uniform pressure distribution at optimal torque value. Experimental and theoretical results were compared for making inferences about optimal cell perfor­man­ce. A

  19. Optimal Fluorescence Waveband Determination for Detecting Defective Cherry Tomatoes Using a Fluorescence Excitation-Emission Matrix

    Directory of Open Access Journals (Sweden)

    In-Suck Baek

    2014-11-01

    Full Text Available A multi-spectral fluorescence imaging technique was used to detect defective cherry tomatoes. The fluorescence excitation and emission matrix was used to measure for defects, sound surface and stem areas to determine the optimal fluorescence excitation and emission wavelengths for discrimination. Two-way ANOVA revealed the optimal excitation wavelength for detecting defect areas was 410 nm. Principal component analysis (PCA was applied to the fluorescence emission spectra of all regions at 410 nm excitation to determine the emission wavelengths for defect detection. The major emission wavelengths were 688 nm and 506 nm for the detection. Fluorescence images combined with the determined emission wavebands demonstrated the feasibility of detecting defective cherry tomatoes with >98% accuracy. Multi-spectral fluorescence imaging has potential utility in non-destructive quality sorting of cherry tomatoes.

  20. An Optimization Method of Time Window Based on Travel Time and Reliability

    OpenAIRE

    Fu, Fengjie; Ma, Dongfang; Wang, Dianhai; Qian, Wei

    2015-01-01

    The dynamic change of urban road travel time was analyzed using video image detector data, and it showed cyclic variation, so the signal cycle length at the upstream intersection was conducted as the basic unit of time window; there was some evidence of bimodality in the actual travel time distributions; therefore, the fitting parameters of the travel time bimodal distribution were estimated using the EM algorithm. Then the weighted average value of the two means was indicated as the travel t...

  1. The study of NMR relaxation time spectra multi-exponential inversion based on Lloyd–Max optimal quantization

    International Nuclear Information System (INIS)

    Li, Xuewei; Kong, Li; Cheng, Jingjing; Wu, Lei

    2015-01-01

    The multi-exponential inversion of a NMR relaxation signal plays a key role in core analysis and logging interpretation in the formation of porous media. To find an efficient metod of inverting high-resolution relaxation time spectra rapidly, this paper studies the effect of inversion which is based on the discretization of the original echo in a time domain by using a simulation model. This paper analyzes the ill-condition of discrete equations on the basis of the NMR inversion model and method, determines the appropriate number of discrete echoes and acquires the optimal distribution of discrete echo points by the Lloyd–Max optimal quantization method, in considering the inverse precision and computational complexity comprehensively. The result shows that this method can effectively improve the efficiency of the relaxation time spectra inversion while guaranteeing inversed accuracy. (paper)

  2. 3D Pattern Synthesis of Time-Modulated Conformal Arrays with a Multiobjective Optimization Approach

    Directory of Open Access Journals (Sweden)

    Wentao Li

    2014-01-01

    Full Text Available This paper addresses the synthesis of the three-dimensional (3D radiation patterns of the time-modulated conformal arrays. Due to the nature of periodic time modulation, harmonic radiation patterns are generated at the multiples of the modulation frequency in time-modulated arrays. Thus, the optimization goal of the time-modulated conformal array includes the optimization of the sidelobe level at the operating frequency and the sideband levels (SBLs at the harmonic frequency, and the design can be regarded as a multiobjective problem. The multiobjective particle swarm optimization (MOPSO is applied to optimize the switch-on instants and pulse durations of the time-modulated conformal array. To significantly reduce the optimization variables, the modified Bernstein polynomial is employed in the synthesis process. Furthermore, dual polarized patch antenna is designed as radiator to achieve low cross-polarization level during the beam scanning. A 12 × 13 (156-element conical conformal microstrip array is simulated to demonstrate the proposed synthesis mechanism, and good results reveal the promising ability of the proposed algorithm in solving the synthesis of the time-modulated conformal arrays problem.

  3. Computer realization of an algorithm for determining the optimal arrangement of a fast power reactor core with hexagonal assemblies

    International Nuclear Information System (INIS)

    Karpov, V.A.; Rybnikov, A.F.

    1983-01-01

    An algorithm for solving the problems associated with fast nuclear reactor computer-aided design is suggested. Formulation of the discrete optimization problem dealing with chosing of the first loading arrangement, determination of the control element functional purpose and the order of their rearrangement during reactor operation as well as the choice of operations for core reloading is given. An algorithm for computerized solutions of the mentioned optimization problem based on variational methods relized in the form of the DESIGN program complex written in FORTRAN for the BEhSM-6 computer is proposed. A fast-response program for solving the diffusion equations of two-dimensional reactor permitting to obtain the optimization problem solution at reasonable period of time is developed to conduct necessary neutron-physical calculations for the reactor in hexagonal geometry. The DESIGN program can be included into a computer-aided design system for automation of the procedure of determining the fast power reactor core arrangement. Application of the DESIGN program permits to avoid the routine calculations on substantiation of neutron-physical and thermal-hydraulic characteristics of the reactor core that releases operators from essential waste of time and increases efficiency of their work

  4. Simultaneous time-optimal control of the inversion of two spin-(1/2) particles

    International Nuclear Information System (INIS)

    Assemat, E.; Lapert, M.; Sugny, D.; Zhang, Y.; Braun, M.; Glaser, S. J.

    2010-01-01

    We analyze the simultaneous time-optimal control of two-spin systems. The two noncoupled spins, which differ in the value of their chemical offsets, are controlled by the same magnetic fields. Using an appropriate rotating frame, we restrict the study to the case of opposite shifts. We then show that the optimal solution of the inversion problem in a rotating frame is composed of a pulse sequence of maximum intensity and is similar to the optimal solution for inverting only one spin by using a nonresonant control field in the laboratory frame. An example is implemented experimentally using nuclear magnetic resonance techniques.

  5. Optimization of incident EC wave polarization in real-time polarization scan experiments on LHD

    International Nuclear Information System (INIS)

    Tsujimura, Toru I.; Mizuno, Yoshinori; Makino, Ryohei

    2016-01-01

    Real-time polarization scan experiments were performed on the Large Helical Device (LHD) to search an optimal incident wave polarization for electron cyclotron resonance heating. The obtained optimal polarization state to maximize the power absorption to the LHD plasma is compared with the ray-tracing code that includes mode content analyses, which indicates that the calculated results are generally in good agreement with the experimental results. The analyses show that optimal coupling to plasma waves requires a fine adjustment for an incident wave polarization even for perpendicular injection due to the finite density profile and the magnetic shear at the peripheral region. (author)

  6. Optimal control of LQR for discrete time-varying systems with input delays

    Science.gov (United States)

    Yin, Yue-Zhu; Yang, Zhong-Lian; Yin, Zhi-Xiang; Xu, Feng

    2018-04-01

    In this work, we consider the optimal control problem of linear quadratic regulation for discrete time-variant systems with single input and multiple input delays. An innovative and simple method to derive the optimal controller is given. The studied problem is first equivalently converted into a problem subject to a constraint condition. Last, with the established duality, the problem is transformed into a static mathematical optimisation problem without input delays. The optimal control input solution to minimise performance index function is derived by solving this optimisation problem with two methods. A numerical simulation example is carried out and its results show that our two approaches are both feasible and very effective.

  7. Preventive maintenance: optimization of time - based discard decisions at the bruce nuclear generating station

    International Nuclear Information System (INIS)

    Doyle, E.K.; Jardine, A.K.S.

    2001-01-01

    The use of various maintenance optimization techniques at Bruce has lead to cost effective preventive maintenance applications for complex systems. As previously reported at ICONE 6 in New Orleans, 1996, several innovative practices reduced Reliability Centered Maintenance costs while maintaining the accuracy of the analysis. The optimization strategy has undergone further evolution and at the present an Integrated Maintenance Program (IMP) is in place where an Expert Panel consisting of all players/experts proceed through each system in a disciplined fashion and reach agreement on all items under a rigorous time frame. It is well known that there are essentially 3 maintenance based actions that can flow from a Maintenance Optimization Analysis: condition based maintenance, time based maintenance and time based discard. The present effort deals with time based discard decisions. Maintenance data from the Remote On-Power Fuel Changing System was used. (author)

  8. Mean-Variance portfolio optimization when each asset has individual uncertain exit-time

    Directory of Open Access Journals (Sweden)

    Reza Keykhaei

    2016-12-01

    Full Text Available The standard Markowitz Mean-Variance optimization model is a single-period portfolio selection approach where the exit-time (or the time-horizon is deterministic. ‎In this paper we study the Mean-Variance portfolio selection problem ‎with ‎uncertain ‎exit-time ‎when ‎each ‎has ‎individual uncertain ‎xit-time‎, ‎which generalizes the Markowitz's model‎. ‎‎‎‎‎‎We provide some conditions under which the optimal portfolio of the generalized problem is independent of the exit-times distributions. Also, ‎‎it is shown that under some general circumstances, the sets of optimal portfolios‎ ‎in the generalized model and the standard model are the same‎.

  9. Optimization of determination of 126Sn by ion exchange chromatography method (presentation)

    International Nuclear Information System (INIS)

    Pasteka, L.; Dulanska, S.

    2013-01-01

    The aim of the work is to optimize the uptake of tin on anion exchange resins and application of this knowledge for the analysis of samples of radioactive waste from the device of Jaslovske Bohunice and Mochovce in determining of 126 Sn. First to be optimized a method for the separation of tin on ion exchange sorbent Anion Exchange Resin (1-X8, Chloride Form) from Eichrom Technologies. Model sample was prepared in 7 mol dm -3 HCl, because in that environment a sorbent effectively captures the tin, which is bounded complexly with chloride anions as SnCl 6 2- . The radiochemical separation yield was monitored by gamma spectrometric measurements on high purity germanium detector HPGe (E = 391 keV) by adding isotope 113 Sn to each model solution. The method of tin separation was optimized on model samples.

  10. Multivariate optimization of an ultrasound-assisted extraction procedure for Cu, Mn, Ni and Zn determination in ration to chickens

    Directory of Open Access Journals (Sweden)

    JOELIA M. BARROS

    2013-09-01

    Full Text Available In this work, multivariate optimization techniques were used to develop a method based on the ultrasound-assisted extraction for copper, manganese, nickel and zinc determination from rations for chicken nutrition using flame atomic absorption spectrometry. The proportions of extracting components (2.0 mol.L–1 nitric, hydrochloric and acetic acid solutions were optimized using centroid-simplex mixture design. The optimum proportions of this mixture taken as percentage of each component were respectively 20%, 37% and 43%. Variables of method (sample mass, sonication time and final acid concentration were optimized using Doehlert design. The optimum values found for these variables were respectively 0.24 g, 18s and 3.6 mol.L–1. The developed method allows copper, manganese, nickel and zinc determination with quantification limits of 2.82; 4.52; 10.7; e 9.69 µg.g–1, and precision expressed as relative standard deviation (%RSD, 25 µg.g–1, N = 5 of 5.30; 2.13; 0.88; and 0.83%, respectively. This method was applied in the analytes determination from chicken rations collected from specialized commerce in Jequié city (Bahia State/Brazil. Application of paired t-test at the obtained results, in a confidence level of 95%, does not show significant difference between the proposed method and the microwave-assisted digestion.

  11. Mean-variance Optimal Reinsurance-investment Strategy in Continuous Time

    Directory of Open Access Journals (Sweden)

    Daheng Peng

    2017-10-01

    Full Text Available In this paper, Lagrange method is used to solve the continuous-time mean-variance reinsurance-investment problem. Proportional reinsurance, multiple risky assets and risk-free asset are considered synthetically in the optimal strategy for insurers. By solving the backward stochastic differential equation for the Lagrange multiplier, we get the mean-variance optimal reinsurance-investment strategy and its effective frontier in explicit forms.

  12. Optimizing Ship Speed to Minimize Total Fuel Consumption with Multiple Time Windows

    Directory of Open Access Journals (Sweden)

    Jae-Gon Kim

    2016-01-01

    Full Text Available We study the ship speed optimization problem with the objective of minimizing the total fuel consumption. We consider multiple time windows for each port call as constraints and formulate the problem as a nonlinear mixed integer program. We derive intrinsic properties of the problem and develop an exact algorithm based on the properties. Computational experiments show that the suggested algorithm is very efficient in finding an optimal solution.

  13. An accurate approximate solution of optimal sequential age replacement policy for a finite-time horizon

    International Nuclear Information System (INIS)

    Jiang, R.

    2009-01-01

    It is difficult to find the optimal solution of the sequential age replacement policy for a finite-time horizon. This paper presents an accurate approximation to find an approximate optimal solution of the sequential replacement policy. The proposed approximation is computationally simple and suitable for any failure distribution. Their accuracy is illustrated by two examples. Based on the approximate solution, an approximate estimate for the total cost is derived.

  14. Core design and operation optimization methods based on time-dependent perturbation theory

    International Nuclear Information System (INIS)

    Greenspan, E.

    1983-08-01

    A general approach for the optimization of nuclear reactor core design and operation is outlined; it is based on two cornerstones: a newly developed time-dependent (or burnup-dependent) perturbation theory for nonlinear problems and a succesive iteration technique. The resulting approach is capable of handling realistic reactor models using computational methods of any degree of sophistication desired, while accounting for all the constraints imposed. Three general optimization strategies, different in the way for handling the constraints, are formulated. (author)

  15. Mean-variance Optimal Reinsurance-investment Strategy in Continuous Time

    OpenAIRE

    Daheng Peng; Fang Zhang

    2017-01-01

    In this paper, Lagrange method is used to solve the continuous-time mean-variance reinsurance-investment problem. Proportional reinsurance, multiple risky assets and risk-free asset are considered synthetically in the optimal strategy for insurers. By solving the backward stochastic differential equation for the Lagrange multiplier, we get the mean-variance optimal reinsurance-investment strategy and its effective frontier in explicit forms.

  16. An Efficient Algorithm for the Optimal Market Timing over Two Stocks

    Institute of Scientific and Technical Information of China (English)

    Hui Li; Hong-zhi An; Guo-fu Wu

    2004-01-01

    In this paper,the optimal trading strategy in timing the market by switching between two stocks is given.In order to deal with a large sample size with a fast turnaround computation time,we propose a class of recursive algorithm.A simulation is given to verify the efiectiveness of our method.

  17. Optimizing the Timing of Expert Feedback During Simulation-Based Spaced Practice of Endourologic Skills.

    Science.gov (United States)

    Lee, Jason Young; McDougall, Elspeth M; Lineberry, Matthew; Tekian, Ara

    2016-08-01

    Provision of expert feedback is widely acknowledged to be an essential component of simulation-based training. However, little is known about the most effective and efficient ways to provide feedback to novices. Optimizing the timing of expert feedback may improve outcomes while reducing resource requirements. The main objective of this study was to determine the impact of providing early versus late expert feedback to novice learners engaged in a flexible ureteroscopy (fURS) training curriculum. Senior medical students were recruited to participate in this study. Each student participated in a comprehensive fURS training curriculum that included 3 deliberate, independent practice sessions. Baseline and postcourse fURS skill was assessed for each student using a standardized fURS test task. Each student was randomized to either an early feedback group (EFG) or late feedback group (LFG). The EFG participants were provided expert feedback immediately after the baseline skill test, whereas LFG participants were given feedback before their final deliberate, independent practice session. Eighteen senior medical students completed the study (9 EFG and 9 LFG participants). There were no discernible demographic differences between the groups at baseline. When controlling for pretest performance, early rather than late feedback was associated with both shorter postcourse time to completion of the task (19.2 vs. 21.5 minutes, P feedback when learning a novel skill. Further study is required.

  18. Efficiency of timing delays and electrode positions in optimization of biventricular pacing: a simulation study.

    Science.gov (United States)

    Miri, Raz; Graf, Iulia M; Dössel, Olaf

    2009-11-01

    Electrode positions and timing delays influence the efficacy of biventricular pacing (BVP). Accordingly, this study focuses on BVP optimization, using a detailed 3-D electrophysiological model of the human heart, which is adapted to patient-specific anatomy and pathophysiology. The research is effectuated on ten heart models with left bundle branch block and myocardial infarction derived from magnetic resonance and computed tomography data. Cardiac electrical activity is simulated with the ten Tusscher cell model and adaptive cellular automaton at physiological and pathological conduction levels. The optimization methods are based on a comparison between the electrical response of the healthy and diseased heart models, measured in terms of root mean square error (E(RMS)) of the excitation front and the QRS duration error (E(QRS)). Intra- and intermethod associations of the pacing electrodes and timing delays variables were analyzed with statistical methods, i.e., t -test for dependent data, one-way analysis of variance for electrode pairs, and Pearson model for equivalent parameters from the two optimization methods. The results indicate that lateral the left ventricle and the upper or middle septal area are frequently (60% of cases) the optimal positions of the left and right electrodes, respectively. Statistical analysis proves that the two optimization methods are in good agreement. In conclusion, a noninvasive preoperative BVP optimization strategy based on computer simulations can be used to identify the most beneficial patient-specific electrode configuration and timing delays.

  19. Real-time parameter optimization based on neural network for smart injection molding

    Science.gov (United States)

    Lee, H.; Liau, Y.; Ryu, K.

    2018-03-01

    The manufacturing industry has been facing several challenges, including sustainability, performance and quality of production. Manufacturers attempt to enhance the competitiveness of companies by implementing CPS (Cyber-Physical Systems) through the convergence of IoT(Internet of Things) and ICT(Information & Communication Technology) in the manufacturing process level. Injection molding process has a short cycle time and high productivity. This features have been making it suitable for mass production. In addition, this process is used to produce precise parts in various industry fields such as automobiles, optics and medical devices. Injection molding process has a mixture of discrete and continuous variables. In order to optimized the quality, variables that is generated in the injection molding process must be considered. Furthermore, Optimal parameter setting is time-consuming work to predict the optimum quality of the product. Since the process parameter cannot be easily corrected during the process execution. In this research, we propose a neural network based real-time process parameter optimization methodology that sets optimal process parameters by using mold data, molding machine data, and response data. This paper is expected to have academic contribution as a novel study of parameter optimization during production compare with pre - production parameter optimization in typical studies.

  20. Determination of quenching coefficients by time resolved emission spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Gans, T.; Schulz-von der Gathen, V.; Doebele, H.F. [Essen Univ. (Gesamthochschule) (Germany). Inst. fuer Laser- und Plasmaphysik

    2001-07-01

    Capacitively coupled RF discharges (CCRF discharges) at 13.56 MHz in hydrogen exhibit a field reversal phase of about 10 ns during which an intense electron current provides collisional excitation, within the sheath region. After this strongly dominant short pulsed electron impact excitation, it is possible to determine quenching coefficients from the lifetime of the fluorescence at various pressures by time resolved OES even for high energy levels and without any restrictions of optical selection rules. This novel technique allows the measurement of quenching coefficients for atomic and molecular emission lines of hydrogen itself, as well as for emission lines of small admixtures (e.g. noble gases) to the hydrogen discharge, since with a fast gate-able ICCD camera operating at 13.56 MHz it is possible to measure even faint emission lines temporally resolved.

  1. Determination of quenching coefficients by time resolved emission spectroscopy

    International Nuclear Information System (INIS)

    Gans, T.; Schulz-von der Gathen, V.; Doebele, H.F.

    2001-01-01

    Capacitively coupled RF discharges (CCRF discharges) at 13.56 MHz in hydrogen exhibit a field reversal phase of about 10 ns during which an intense electron current provides collisional excitation, within the sheath region. After this strongly dominant short pulsed electron impact excitation, it is possible to determine quenching coefficients from the lifetime of the fluorescence at various pressures by time resolved OES even for high energy levels and without any restrictions of optical selection rules. This novel technique allows the measurement of quenching coefficients for atomic and molecular emission lines of hydrogen itself, as well as for emission lines of small admixtures (e.g. noble gases) to the hydrogen discharge, since with a fast gate-able ICCD camera operating at 13.56 MHz it is possible to measure even faint emission lines temporally resolved

  2. Joint optimization of economic production quantity and preventive maintenance with considering multi-products and reserve time

    International Nuclear Information System (INIS)

    Liu, Xuejuan; Wang, Binrong

    2017-01-01

    Purpose: We deal with the problem of the joint determination of optimal economic production quantity (EPQ) and optimal preventive maintenance (PM) for a system that can produce multiple products alternately. The objective is to find the optimal number of production cycles and the PM policy simultaneously by minimizing the cost model. Design/methodology/approach: Considering the products go through the system in a sequence and a complete run of all products forms a production cycle. In each cycle, beyond production time we also consider some reserve time for maintenance and setup, shortage and overproduction may occur. We study the integrated problem based on two PM policies, and explain the situation with the other PM policies. The delay – time concept is used to model PM decisions. Findings: Using the integrated EPQ and PM model, we can calculate the optimal production planning and PM schedule simultaneously, especially we consider multiple products in each production cycle, which is more practical and economic than previous works. Originality/value: In modern companies, the production planning and maintenance schedule share the same system, and traditional research about two activities is separated, that always generate conflicts, such as inadequate or excessive maintenance, and shortages, etc., so we develop the integrated EPQ and PM model to avoid these undesirable effects.

  3. Joint optimization of economic production quantity and preventive maintenance with considering multi-products and reserve time

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xuejuan; Wang, Binrong

    2017-07-01

    Purpose: We deal with the problem of the joint determination of optimal economic production quantity (EPQ) and optimal preventive maintenance (PM) for a system that can produce multiple products alternately. The objective is to find the optimal number of production cycles and the PM policy simultaneously by minimizing the cost model. Design/methodology/approach: Considering the products go through the system in a sequence and a complete run of all products forms a production cycle. In each cycle, beyond production time we also consider some reserve time for maintenance and setup, shortage and overproduction may occur. We study the integrated problem based on two PM policies, and explain the situation with the other PM policies. The delay – time concept is used to model PM decisions. Findings: Using the integrated EPQ and PM model, we can calculate the optimal production planning and PM schedule simultaneously, especially we consider multiple products in each production cycle, which is more practical and economic than previous works. Originality/value: In modern companies, the production planning and maintenance schedule share the same system, and traditional research about two activities is separated, that always generate conflicts, such as inadequate or excessive maintenance, and shortages, etc., so we develop the integrated EPQ and PM model to avoid these undesirable effects.

  4. Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles.

    Science.gov (United States)

    Shin, Sangmun; Choi, Du Hyung; Truong, Nguyen Khoa Viet; Kim, Nam Ah; Chu, Kyung Rok; Jeong, Seong Hoon

    2011-04-04

    A new experimental design methodology was developed by integrating the response surface methodology and the time series modeling. The major purposes were to identify significant factors in determining swelling and release rate from matrix tablets and their relative factor levels for optimizing the experimental responses. Properties of tablet swelling and drug release were assessed with ten factors and two default factors, a hydrophilic model drug (terazosin) and magnesium stearate, and compared with target values. The selected input control factors were arranged in a mixture simplex lattice design with 21 experimental runs. The obtained optimal settings for gelation were PEO, LH-11, Syloid, and Pharmacoat with weight ratios of 215.33 (88.50%), 5.68 (2.33%), 19.27 (7.92%), and 3.04 (1.25%), respectively. The optimal settings for drug release were PEO and citric acid with weight ratios of 191.99 (78.91%) and 51.32 (21.09%), respectively. Based on the results of matrix swelling and drug release, the optimal solutions, target values, and validation experiment results over time were similar and showed consistent patterns with very small biases. The experimental design methodology could be a very promising experimental design method to obtain maximum information with limited time and resources. It could also be very useful in formulation studies by providing a systematic and reliable screening method to characterize significant factors in the sustained release matrix tablet. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. Method to determine the optimal constitutive model from spherical indentation tests

    Directory of Open Access Journals (Sweden)

    Tairui Zhang

    2018-03-01

    Full Text Available The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed. Two constitutive models, the Power-law and the Linear-law, were used in Finite Element (FE calculations, and then a set of indentation governing equations was established for each model. The load-depth data from the normal indentation depth was used to fit the best parameters in each constitutive model while the data from the further loading part was compared with those from FE calculations, and the model that better predicted the further deformation was considered the optimal one. Moreover, a Yang’s modulus calculation model which took the previous plastic deformation and the phenomenon of pile-up (or sink-in into consideration was also proposed to revise the original Sneddon-Pharr-Oliver model. The indentation results on six materials, 304, 321, SA508, SA533, 15CrMoR, and Fv520B, were compared with tensile ones, which validated the reliability of the revised E calculation model and the optimal constitutive model determination method in this study. Keywords: Optimal constitutive model, Spherical indentation test, Finite Element calculations, Yang’s modulus

  6. Multi-Objective Optimization for Smart House Applied Real Time Pricing Systems

    Directory of Open Access Journals (Sweden)

    Yasuaki Miyazato

    2016-12-01

    Full Text Available A smart house generally has a Photovoltaic panel (PV, a Heat Pump (HP, a Solar Collector (SC and a fixed battery. Since the fixed battery can buy and store inexpensive electricity during the night, the electricity bill can be reduced. However, a large capacity fixed battery is very expensive. Therefore, there is a need to determine the economic capacity of fixed battery. Furthermore, surplus electric power can be sold using a buyback program. By this program, PV can be effectively utilized and contribute to the reduction of the electricity bill. With this in mind, this research proposes a multi-objective optimization, the purpose of which is electric demand control and reduction of the electricity bill in the smart house. In this optimal problem, the Pareto optimal solutions are searched depending on the fixed battery capacity. Additionally, it is shown that consumers can choose what suits them by comparing the Pareto optimal solutions.

  7. Technical Note: Using experimentally determined proton spot scanning timing parameters to accurately model beam delivery time.

    Science.gov (United States)

    Shen, Jiajian; Tryggestad, Erik; Younkin, James E; Keole, Sameer R; Furutani, Keith M; Kang, Yixiu; Herman, Michael G; Bues, Martin

    2017-10-01

    To accurately model the beam delivery time (BDT) for a synchrotron-based proton spot scanning system using experimentally determined beam parameters. A model to simulate the proton spot delivery sequences was constructed, and BDT was calculated by summing times for layer switch, spot switch, and spot delivery. Test plans were designed to isolate and quantify the relevant beam parameters in the operation cycle of the proton beam therapy delivery system. These parameters included the layer switch time, magnet preparation and verification time, average beam scanning speeds in x- and y-directions, proton spill rate, and maximum charge and maximum extraction time for each spill. The experimentally determined parameters, as well as the nominal values initially provided by the vendor, served as inputs to the model to predict BDTs for 602 clinical proton beam deliveries. The calculated BDTs (T BDT ) were compared with the BDTs recorded in the treatment delivery log files (T Log ): ∆t = T Log -T BDT . The experimentally determined average layer switch time for all 97 energies was 1.91 s (ranging from 1.9 to 2.0 s for beam energies from 71.3 to 228.8 MeV), average magnet preparation and verification time was 1.93 ms, the average scanning speeds were 5.9 m/s in x-direction and 19.3 m/s in y-direction, the proton spill rate was 8.7 MU/s, and the maximum proton charge available for one acceleration is 2.0 ± 0.4 nC. Some of the measured parameters differed from the nominal values provided by the vendor. The calculated BDTs using experimentally determined parameters matched the recorded BDTs of 602 beam deliveries (∆t = -0.49 ± 1.44 s), which were significantly more accurate than BDTs calculated using nominal timing parameters (∆t = -7.48 ± 6.97 s). An accurate model for BDT prediction was achieved by using the experimentally determined proton beam therapy delivery parameters, which may be useful in modeling the interplay effect and patient throughput. The model may

  8. Optimal Parameters to Determine the Apparent Diffusion Coefficient in Diffusion Weighted Imaging via Simulation

    Science.gov (United States)

    Perera, Dimuthu

    Diffusion weighted (DW) Imaging is a non-invasive MR technique that provides information about the tissue microstructure using the diffusion of water molecules. The diffusion is generally characterized by the apparent diffusion coefficient (ADC) parametric map. The purpose of this study is to investigate in silico how the calculation of ADC is affected by image SNR, b-values, and the true tissue ADC. Also, to provide optimal parameter combination depending on the percentage accuracy and precision for prostate peripheral region cancer application. Moreover, to suggest parameter choices for any type of tissue, while providing the expected accuracy and precision. In this research DW images were generated assuming a mono-exponential signal model at two different b-values and for known true ADC values. Rician noise of different levels was added to the DWI images to adjust the image SNR. Using the two DWI images, ADC was calculated using a mono-exponential model for each set of b-values, SNR, and true ADC. 40,000 ADC data were collected for each parameter setting to determine the mean and the standard-deviation of the calculated ADC, as well as the percentage accuracy and precision with respect to the true ADC. The accuracy was calculated using the difference between known and calculated ADC. The precision was calculated using the standard-deviation of calculated ADC. The optimal parameters for a specific study was determined when both the percentage accuracy and precision were minimized. In our study, we simulated two true ADCs (ADC 0.00102 for tumor and 0.00180 mm2/s for normal prostate peripheral region tissue). Image SNR was varied from 2 to 100 and b-values were varied from 0 to 2000s/mm2. The results show that the percentage accuracy and percentage precision were minimized with image SNR. To increase SNR, 10 signal-averagings (NEX) were used considering the limitation in total scan time. The optimal NEX combination for tumor and normal tissue for prostate

  9. Optimal Consumer Electronics Product Take-Back Time with Consideration of Consumer Value

    Directory of Open Access Journals (Sweden)

    Yi-Tse Fang

    2017-03-01

    Full Text Available Rapid economic growth in recent years has transformed our lifestyle to massively produce, consume, and dispose of products, especially for consumer electronics. This change has put great threat to our environment and caused natural resource depletion. Moreover, short product life cycles and quick replacements of consumer electronics create enormous electronic wastes (e-wastes. Without proper waste management, immense environmental damage is expected. In this empirical study, we notice that lots of valuable materials that can still be recycled from these used consumer electronics are left unused at home instead of being recycled at the appropriate time, which causes a low collection rate and a decrease in residual value for the used products. Therefore, it is important for the government and the recyclers to handle them efficiently by increasing the used product take-back rate. Our study develops an assessment model for customer value based on the idea of value engineering and the perspective of product life cycle. We also explore the relationship between product value and the total cost of ownership with an evaluation of their time variation, considering different usage modes for various consumer groups and different recycling award schemes (fixed and variable recycling awards. Proper take-back management is likely to create a win-win situation both for consumers and environmental protection. This study regards the notebook computer as an example to determine the optimal time for recycling laptops based on usage patterns and provides consumers a reference for when to replace their used product. The results from our modeling firstly clearly indicate that consumers with higher frequency of usage have shorter take back times and higher maximum consumer value. Secondly, a variable recycling award scheme with higher maximum consumer value is more practical than a fixed recycling award scheme.

  10. Optimal Investment Timing and Size of a Logistics Park: A Real Options Perspective

    Directory of Open Access Journals (Sweden)

    Dezhi Zhang

    2017-01-01

    Full Text Available This paper uses a real options approach to address optimal timing and size of a logistics park investment with logistics demand volatility. Two important problems are examined: when should an investment be introduced, and what size should it be? A real option model is proposed to explicitly incorporate the effect of government subsidies on logistics park investment. Logistic demand that triggers the threshold for investment in a logistics park project is explored analytically. Comparative static analyses of logistics park investment are also carried out. Our analytical results show that (1 investors will select smaller sized logistics parks and prepone the investment if government subsidies are considered; (2 the real option will postpone the optimal investment timing of logistics parks compared with net present value approach; and (3 logistic demands can significantly affect the optimal investment size and timing of logistics park investment.

  11. Optimal Load Response to Time-of-Use Power Price for Demand Side Management in Denmark

    DEFF Research Database (Denmark)

    Hu, Weihao; Chen, Zhe; Bak-Jensen, Birgitte

    2010-01-01

    -of-use power price for demand side management in order to save the energy costs as much as possible. 3 typical different kinds of loads (industrial load, residential load and commercial load) in Denmark are chosen as study cases. The energy costs decrease up to 9.6% with optimal load response to time......-of-use power price for different loads. Simulation results show that the optimal load response to time-of-use power price for demand side management generates different load profiles and reduces the load peaks. This kind of load patterns may also have significant effects on the power system normal operation.......Since the hourly spot market price is available one day ahead in Denmark, the price could be transferred to the consumers and they may shift their loads from high price periods to the low price periods in order to save their energy costs. This paper presents a load optimization method to time...

  12. Real-time Collision Avoidance and Path Optimizer for Semi-autonomous UAVs.

    Science.gov (United States)

    Hawary, A. F.; Razak, N. A.

    2018-05-01

    Whilst UAV offers a potentially cheaper and more localized observation platform than current satellite or land-based approaches, it requires an advance path planner to reveal its true potential, particularly in real-time missions. Manual control by human will have limited line-of-sights and prone to errors due to careless and fatigue. A good alternative solution is to equip the UAV with semi-autonomous capabilities that able to navigate via a pre-planned route in real-time fashion. In this paper, we propose an easy-and-practical path optimizer based on the classical Travelling Salesman Problem and adopts a brute force search method to re-optimize the route in the event of collisions using range finder sensor. The former utilizes a Simple Genetic Algorithm and the latter uses Nearest Neighbour algorithm. Both algorithms are combined to optimize the route and avoid collision at once. Although many researchers proposed various path planning algorithms, we find that it is difficult to integrate on a basic UAV model and often lacks of real-time collision detection optimizer. Therefore, we explore a practical benefit from this approach using on-board Arduino and Ardupilot controllers by manually emulating the motion of an actual UAV model prior to test on the flying site. The result showed that the range finder sensor provides a real-time data to the algorithm to find a collision-free path and eventually optimized the route successfully.

  13. Determination of gallic acid with rhodanine by reverse flow injection analysis using simplex optimization.

    Science.gov (United States)

    Phakthong, Wilaiwan; Liawruangrath, Boonsom; Liawruangrath, Saisunee

    2014-12-01

    A reversed flow injection (rFI) system was designed and constructed for gallic acid determination. Gallic acid was determined based on the formation of chromogen between gallic acid and rhodanine, resulting in a colored product with a λmax at 520 nm. The optimum conditions for determining gallic acid were also investigated. Optimizations of the experimental conditions were carried out based on the so-call univariate method. The conditions obtained were 0.6% (w/v) rhodanine, 70% (v/v) ethanol, 0.9 mol L(-1) NaOH, 2.0 mL min(-1) flow rate, 75 μL injection loop and 600 cm mixing tubing length, respectively. Comparative optimizations of the experimental conditions were also carried out by multivariate or simplex optimization method. The conditions obtained were 1.2% (w/v) rhodanine, 70% (v/v) ethanol, 1.2 mol L(-1) NaOH, flow rate 2.5 mL min(-1), 75 μL injection loop and 600 cm mixing tubing length, respectively. It was found that the optimum conditions obtained by the former optimization method were mostly similar to those obtained by the latter method. The linear relationship between peak height and the concentration of gallic acid was obtained over the range of 0.1-35.0 mg L(-1) with the detection limit 0.081 mg L(-1). The relative standard deviations were found to be in the ranges 0.46-1.96% for 1, 10, 30 mg L(-1) of gallic acid (n=11). The method has the advantages of simplicity extremely high selectivity and high precision. The proposed method was successfully applied to the determination of gallic acid in longan samples without interferent effects from other common phenolic compounds that might be present in the longan samples collected in northern Thailand. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Robust Optimization for Time-Cost Tradeoff Problem in Construction Projects

    Directory of Open Access Journals (Sweden)

    Ming Li

    2014-01-01

    Full Text Available Construction projects are generally subject to uncertainty, which influences the realization of time-cost tradeoff in project management. This paper addresses a time-cost tradeoff problem under uncertainty, in which activities in projects can be executed in different construction modes corresponding to specified time and cost with interval uncertainty. Based on multiobjective robust optimization method, a robust optimization model for time-cost tradeoff problem is developed. In order to illustrate the robust model, nondominated sorting genetic algorithm-II (NSGA-II is modified to solve the project example. The results show that, by means of adjusting the time and cost robust coefficients, the robust Pareto sets for time-cost tradeoff can be obtained according to different acceptable risk level, from which the decision maker could choose the preferred construction alternative.

  15. Optimization of Time-Partitions for Mixed-Criticality Real-Time Distributed Embedded Systems

    DEFF Research Database (Denmark)

    Tamas-Selicean, Domitian; Pop, Paul

    2011-01-01

    In this paper we are interested in mixed-criticality embedded real-time applications mapped on distributed heterogeneous architectures. The architecture provides both spatial and temporal partitioning, thus enforcing enough separation for the critical applications. With temporal partitioning, each...

  16. Amplitude and rise time compensated timing optimized for large semiconductor detectors

    International Nuclear Information System (INIS)

    Kozyczkowski, J.J.; Bialkowski, J.

    1976-01-01

    The ARC timing described has excellent timing properties even when using a wide range e.g. from 10 keV to over 1 MeV. The detector signal from a preamplifier is accepted directly by the unit as a timing filter amplifier with a sensitivity of 1 mV is incorporated. The adjustable rise time rejection feature makes it possible to achieve a good prompt time spectrum with symmetrical exponential shape down to less than 1/100 of the peak value. A complete block diagram of the unit is given together with results of extensive tests of its performance. For example the time spectrum for (1330+-20) keV of 60 Co taken with a 43 cm 3 Ge(Li) detector has the following parameters: fwhm = 2.2ns, fwtm = 4.4 ns and fw (0.01) m = 7.6 ns and for (50 +- 10) keV of 22 Na the following was obtained: fwhm = 10.8 ns, fwtm = 21.6 ns and fw (0.01) m = 34.6 ns. In another experiment with two fast plastic scintillations (NE 102A) and using a 20% dynamic energy range the following was measured: fwhm = 280 ps, fwtm = 470 ps and fw (0.01) m = 70ps. (Auth.)

  17. Optimization of antifungal activity of Aeollanthus heliotropioides oliv essential oil and Time Kill Kinetic Assay.

    Science.gov (United States)

    Ngo Mback, M N L; Agnaniet, H; Nguimatsia, F; Jazet Dongmo, P-M; Hzounda Fokou, J-B; Bakarnga-Via, I; Fekam Boyom, F; Menut, C

    2016-09-01

    The limitations encountered in the management of fungal infections are due to the resistance, high toxicity, and overuse of conventional antifungal drugs. For bringing solutions, the antifungal activity of Aeollanthus heliotropioides essential oil will be evaluated and optimized. The aerial parts of A. heliotropioides were harvested and essential oil extracted by hydrodistillation. The chemical composition was determined using gas chromatography and gas chromatography coupled with mass spectrometry and nuclear magnetic resonance. The sensitivity of fungal strains was determined using broth microdilution method. The fungicidal parameters were checked by viability assay using methylene blue dye. The Fractional Inhibitory Concentration Index was determined according the two-dimensional checkboard methods. The efficiency of the simulated optimum concentrations confirmed experimentally on American type culture collection strains, through the Time Kill Kinetic Study. The yield of extraction of essential oil was 0.1%. The major compounds were linalool (38.5%), Z-α-farnesene (25.1%), 9-hexa-decen-1-ol (13.9%) saturated/unsaturated massoia and γ-lactones (4.5%). The MIC of extract on yeast isolates ranged from 0.6mg/mL to 5mg/mL. The combination of essential oil with thymol leads mainly to synergistic effects (0.5≤FICI). The optimums of essential oil (1.6±0.4μl/mL) and thymol (0.6±0.1mg/mL) revealed a total inhibition of yeast after 120 and 180minutes according to the yeasts strains used. This study highlights the in vitro antifungal activity of A. heliotropioides essential oil and it synergistic effect with thymol. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  18. Accuracy and optimal timing of activity measurements in estimating the absorbed dose of radioiodine in the treatment of Graves' disease

    Science.gov (United States)

    Merrill, S.; Horowitz, J.; Traino, A. C.; Chipkin, S. R.; Hollot, C. V.; Chait, Y.

    2011-02-01

    Calculation of the therapeutic activity of radioiodine 131I for individualized dosimetry in the treatment of Graves' disease requires an accurate estimate of the thyroid absorbed radiation dose based on a tracer activity administration of 131I. Common approaches (Marinelli-Quimby formula, MIRD algorithm) use, respectively, the effective half-life of radioiodine in the thyroid and the time-integrated activity. Many physicians perform one, two, or at most three tracer dose activity measurements at various times and calculate the required therapeutic activity by ad hoc methods. In this paper, we study the accuracy of estimates of four 'target variables': time-integrated activity coefficient, time of maximum activity, maximum activity, and effective half-life in the gland. Clinical data from 41 patients who underwent 131I therapy for Graves' disease at the University Hospital in Pisa, Italy, are used for analysis. The radioiodine kinetics are described using a nonlinear mixed-effects model. The distributions of the target variables in the patient population are characterized. Using minimum root mean squared error as the criterion, optimal 1-, 2-, and 3-point sampling schedules are determined for estimation of the target variables, and probabilistic bounds are given for the errors under the optimal times. An algorithm is developed for computing the optimal 1-, 2-, and 3-point sampling schedules for the target variables. This algorithm is implemented in a freely available software tool. Taking into consideration 131I effective half-life in the thyroid and measurement noise, the optimal 1-point time for time-integrated activity coefficient is a measurement 1 week following the tracer dose. Additional measurements give only a slight improvement in accuracy.

  19. The determination of dark adaptation time using electroretinography in conscious miniature Schnauzer dogs.

    Science.gov (United States)

    Yu, Hyung-Ah; Jeong, Man-Bok; Park, Shin-Ae; Kim, Won-Tae; Kim, Se-Eun; Chae, Je-Min; Yi, Na-Young; Seo, Kang-Moon

    2007-12-01

    The optimal dark adaptation time of electroretinograms (ERG's) performed on conscious dogs were determined using a commercially available ERG unit with a contact lens electrode and a built-in light source (LED-electrode). The ERG recordings were performed on nine healthy Miniature Schnauzer dogs. The bilateral ERG's at seven different dark adaptation times at an intensity of 2.5 cd.s/m(2) was performed. Signal averaging (4 flashes of light stimuli) was adopted to reduce electrophysiologic noise. As the dark adaptation time increased, a significant increase in the mean a-wave amplitudes was observed in comparison to base-line levels up to 10 min (p Schnauzer dogs.

  20. Parasitic lasing suppression in large-aperture Ti:sapphire amplifiers by optimizing the seed–pump time delay

    International Nuclear Information System (INIS)

    Chu, Y X; Liang, X Y; Yu, L H; Xu, L; Lu, X M; Liu, Y Q; Leng, Y X; Li, R X; Xu, Z Z

    2013-01-01

    Theoretical and experimental investigations are carried out to determine the influence of the time delay between the input seed pulse and pump pulses on transverse parasitic lasing in a Ti:sapphire amplifier with a diameter of 80 mm, which is clad by a refractive index-matched liquid doped with an absorber. When the time delay is optimized, a maximum output energy of 50.8 J is achieved at a pump energy of 105 J, which corresponds to a conversion efficiency of 47.5%. Based on the existing compressor, the laser system achieves a peak power of 1.26 PW with a 29.0 fs pulse duration. (letter)

  1. Selection of the optimal hard facing (HF technology of damaged forging dies based on cooling time t8/5

    Directory of Open Access Journals (Sweden)

    D. Arsić

    2016-01-01

    Full Text Available In exploitation, the forging dies are exposed to heating up to very high temperatures, variable loads: compressive, impact and shear. In this paper, the reparatory hard facing of the damaged forging dies is considered. The objective was to establish the optimal reparatory technology based on cooling time t8/5 . The verification of the adopted technology was done by investigation of the hard faced layers microstructure and measurements of hardness within the welded layers’ characteristic zones. Cooling time was determined theoretically, numerically and experimentally.

  2. Optimal adaptive control for quantum metrology with time-dependent Hamiltonians

    Science.gov (United States)

    Pang, Shengshi; Jordan, Andrew N.

    2017-01-01

    Quantum metrology has been studied for a wide range of systems with time-independent Hamiltonians. For systems with time-dependent Hamiltonians, however, due to the complexity of dynamics, little has been known about quantum metrology. Here we investigate quantum metrology with time-dependent Hamiltonians to bridge this gap. We obtain the optimal quantum Fisher information for parameters in time-dependent Hamiltonians, and show proper Hamiltonian control is generally necessary to optimize the Fisher information. We derive the optimal Hamiltonian control, which is generally adaptive, and the measurement scheme to attain the optimal Fisher information. In a minimal example of a qubit in a rotating magnetic field, we find a surprising result that the fundamental limit of T2 time scaling of quantum Fisher information can be broken with time-dependent Hamiltonians, which reaches T4 in estimating the rotation frequency of the field. We conclude by considering level crossings in the derivatives of the Hamiltonians, and point out additional control is necessary for that case. PMID:28276428

  3. Optimal adaptive control for quantum metrology with time-dependent Hamiltonians.

    Science.gov (United States)

    Pang, Shengshi; Jordan, Andrew N

    2017-03-09

    Quantum metrology has been studied for a wide range of systems with time-independent Hamiltonians. For systems with time-dependent Hamiltonians, however, due to the complexity of dynamics, little has been known about quantum metrology. Here we investigate quantum metrology with time-dependent Hamiltonians to bridge this gap. We obtain the optimal quantum Fisher information for parameters in time-dependent Hamiltonians, and show proper Hamiltonian control is generally necessary to optimize the Fisher information. We derive the optimal Hamiltonian control, which is generally adaptive, and the measurement scheme to attain the optimal Fisher information. In a minimal example of a qubit in a rotating magnetic field, we find a surprising result that the fundamental limit of T 2 time scaling of quantum Fisher information can be broken with time-dependent Hamiltonians, which reaches T 4 in estimating the rotation frequency of the field. We conclude by considering level crossings in the derivatives of the Hamiltonians, and point out additional control is necessary for that case.

  4. Diet selection of African elephant over time shows changing optimization currency

    NARCIS (Netherlands)

    Pretorius, Y.; Stigter, J.D.; Boer, de W.F.; Wieren, van S.E.; Jong, de C.B.; Knegt, de H.J.; Grant, R.C.; Heitkonig, I.M.A.; Knox, N.; Kohi, E.; Mwakiwa, E.; Peel, M.J.S.; Skidmore, A.K.; Slotow, R.; Waal, van der C.; Langevelde, van F.; Prins, H.H.T.

    2012-01-01

    Multiple factors determine diet selection of herbivores. However, in many diet studies selection of single nutrients is studied or optimization models are developed using only one currency. In this paper, we use linear programming to explain diet selection by African elephant based on plant

  5. Real time optimization of solar powered direct contact membrane distillation based on multivariable extremum seeking

    KAUST Repository

    Karam, Ayman M.; Laleg-Kirati, Taous-Meriem

    2015-01-01

    This paper presents a real time optimization scheme for a solar powered direct contact membrane distillation (DCMD) water desalination system. The sun and weather conditions vary and are inconsistent throughout the day. Therefore, the solar powered DCMD feed inlet temperature is never constant, which influences the distilled water flux. The problem of DCMD process optimization has not been studied enough. In this work, the response of the process under various feed inlet temperatures is investigated, which demonstrates the need for an optimal controller. To address this issue, we propose a multivariable Newton-based extremum seeking controller which optimizes the inlet feed and permeate mass flow rates as the feed inlet temperature varies. Results are presented and discussed for a realistic temperature profile.

  6. Real time optimization of solar powered direct contact membrane distillation based on multivariable extremum seeking

    KAUST Repository

    Karam, Ayman M.

    2015-09-21

    This paper presents a real time optimization scheme for a solar powered direct contact membrane distillation (DCMD) water desalination system. The sun and weather conditions vary and are inconsistent throughout the day. Therefore, the solar powered DCMD feed inlet temperature is never constant, which influences the distilled water flux. The problem of DCMD process optimization has not been studied enough. In this work, the response of the process under various feed inlet temperatures is investigated, which demonstrates the need for an optimal controller. To address this issue, we propose a multivariable Newton-based extremum seeking controller which optimizes the inlet feed and permeate mass flow rates as the feed inlet temperature varies. Results are presented and discussed for a realistic temperature profile.

  7. Design Optimization of Time- and Cost-Constrained Fault-Tolerant Distributed Embedded Systems

    DEFF Research Database (Denmark)

    Izosimov, Viacheslav; Pop, Paul; Eles, Petru

    2005-01-01

    In this paper we present an approach to the design optimization of fault-tolerant embedded systems for safety-critical applications. Processes are statically scheduled and communications are performed using the time-triggered protocol. We use process re-execution and replication for tolerating...... transient faults. Our design optimization approach decides the mapping of processes to processors and the assignment of fault-tolerant policies to processes such that transient faults are tolerated and the timing constraints of the application are satisfied. We present several heuristics which are able...

  8. Design Optimization of Multi-Cluster Embedded Systems for Real-Time Applications

    DEFF Research Database (Denmark)

    Pop, Paul; Eles, Petru; Peng, Zebo

    2004-01-01

    We present an approach to design optimization of multi-cluster embedded systems consisting of time-triggered and event-triggered clusters, interconnected via gateways. In this paper, we address design problems which are characteristic to multi-clusters: partitioning of the system functionality...... into time-triggered and event-triggered domains, process mapping, and the optimization of parameters corresponding to the communication protocol. We present several heuristics for solving these problems. Our heuristics are able to find schedulable implementations under limited resources, achieving...... an efficient utilization of the system. The developed algorithms are evaluated using extensive experiments and a real-life example....

  9. Design Optimization of Multi-Cluster Embedded Systems for Real-Time Applications

    DEFF Research Database (Denmark)

    Pop, Paul; Eles, Petru; Peng, Zebo

    2006-01-01

    We present an approach to design optimization of multi-cluster embedded systems consisting of time-triggered and event-triggered clusters, interconnected via gateways. In this paper, we address design problems which are characteristic to multi-clusters: partitioning of the system functionality...... into time-triggered and event-triggered domains, process mapping, and the optimization of parameters corresponding to the communication protocol. We present several heuristics for solving these problems. Our heuristics are able to find schedulable implementations under limited resources, achieving...... an efficient utilization of the system. The developed algorithms are evaluated using extensive experiments and a real-life example....

  10. Reliable Rescue Routing Optimization for Urban Emergency Logistics under Travel Time Uncertainty

    Directory of Open Access Journals (Sweden)

    Qiuping Li

    2018-02-01

    Full Text Available The reliability of rescue routes is critical for urban emergency logistics during disasters. However, studies on reliable rescue routing under stochastic networks are still rare. This paper proposes a multiobjective rescue routing model for urban emergency logistics under travel time reliability. A hybrid metaheuristic integrating ant colony optimization (ACO and tabu search (TS was designed to solve the model. An experiment optimizing rescue routing plans under a real urban storm event, was carried out to validate the proposed model. The experimental results showed how our approach can improve rescue efficiency with high travel time reliability.

  11. Multivariate optimization of headspace trap for furan and furfural simultaneous determination in sponge cake.

    Science.gov (United States)

    Cepeda-Vázquez, Mayela; Blumenthal, David; Camel, Valérie; Rega, Barbara

    2017-03-01

    Furan, a possibly carcinogenic compound to humans, and furfural, a naturally occurring volatile contributing to aroma, can be both found in thermally treated foods. These process-induced compounds, formed by close reaction pathways, play an important role as markers of food safety and quality. A method capable of simultaneously quantifying both molecules is thus highly relevant for developing mitigation strategies and preserving the sensory properties of food at the same time. We have developed a unique reliable and sensitive headspace trap (HS trap) extraction method coupled to GC-MS for the simultaneous quantification of furan and furfural in a solid processed food (sponge cake). HS Trap extraction has been optimized using an optimal design of experiments (O-DOE) approach, considering four instrumental and two sample preparation variables, as well as a blocking factor identified during preliminary assays. Multicriteria and multiple response optimization was performed based on a desirability function, yielding the following conditions: thermostatting temperature, 65°C; thermostatting time, 15min; number of pressurization cycles, 4; dry purge time, 0.9min; water / sample amount ratio (dry basis), 16; and total amount (water + sample amount, dry basis), 10g. The performances of the optimized method were also assessed: repeatability (RSD: ≤3.3% for furan and ≤2.6% for furfural), intermediate precision (RSD: 4.0% for furan and 4.3% for furfural), linearity (R 2 : 0.9957 for furan and 0.9996 for furfural), LOD (0.50ng furan g sample dry basis -1 and 10.2ng furfural g sample dry basis -1 ), LOQ (0.99ng furan g sample dry basis -1 and 41.1ng furfural g sample dry basis -1 ). Matrix effect was observed mainly for furan. Finally, the optimized method was applied to other sponge cakes with different matrix characteristics and levels of analytes. Copyright © 2016. Published by Elsevier B.V.

  12. Determination of Optimal Parameters for Diffusion Bonding of Semi-Solid Casting Aluminium Alloy by Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Kaewploy Somsak

    2015-01-01

    Full Text Available Liquid state welding techniques available are prone to gas porosity problems. To avoid this solid state bonding is usually an alternative of preference. Among solid state bonding techniques, diffusion bonding is often employed in aluminium alloy automotive parts welding in order to enhance their mechanical properties. However, there has been no standard procedure nor has there been any definitive criterion for judicious welding parameters setting. It is thus a matter of importance to find the set of optimal parameters for effective diffusion bonding. This work proposes the use of response surface methodology in determining such a set of optimal parameters. Response surface methodology is more efficient in dealing with complex process compared with other techniques available. There are two variations of response surface methodology. The one adopted in this work is the central composite design approach. This is because when the initial upper and lower bounds of the desired parameters are exceeded the central composite design approach is still capable of yielding the optimal values of the parameters that appear to be out of the initially preset range. Results from the experiments show that the pressing pressure and the holding time affect the tensile strength of jointing. The data obtained from the experiment fits well to a quadratic equation with high coefficient of determination (R2 = 94.21%. It is found that the optimal parameters in the process of jointing semi-solid casting aluminium alloy by using diffusion bonding are the pressing pressure of 2.06 MPa and 214 minutes of the holding time in order to achieve the highest tensile strength of 142.65 MPa

  13. [Clinical research of using optimal compliance to determine positive end-expiratory pressure].

    Science.gov (United States)

    Xu, Lei; Feng, Quan-sheng; Lian, Fu; Shao, Xin-hua; Li, Zhi-bo; Wang, Zhi-yong; Li, Jun

    2012-07-01

    To observe the availability and security of optimal compliance strategy to titrate the optimal positive end-expiratory pressure (PEEP), compared with quasi-static pressure-volume curve (P-V curve) traced by low-flow method. Fourteen patients received mechanical ventilation with acute respiratory distress syndrome (ARDS) admitted in intensive care unit (ICU) of Tianjin Third Central Hospital from November 2009 to December 2010 were divided into two groups(n = 7). The quasi-static P-V curve method and the optimal compliance titration were used to set the optimal PEEP respectively, repeated 3 times in a row. The optimal PEEP and the consistency of repeated experiments were compared between groups. The hemodynamic parameters, oxygenation index (OI), lung compliance (C), cytokines and pulmonary surfactant-associated protein D (SP-D) concentration in plasma before and 2, 4, and 6 hours after the experiment were observed in each group. (1) There were no significant differences in gender, age and severity of disease between two groups. (2)The optimal PEEP [cm H(2)O, 1 cm H(2)O=0.098 kPa] had no significant difference between quasi-static P-V curve method group and the optimal compliance titration group (11.53 ± 2.07 vs. 10.57 ± 0.87, P>0.05). The consistency of repeated experiments in quasi-static P-V curve method group was poor, the slope of the quasi-static P-V curve in repeated experiments showed downward tendency. The optimal PEEP was increasing in each measure. There was significant difference between the first and the third time (10.00 ± 1.58 vs. 12.80 ± 1.92, P vs. 93.71 ± 5.38, temperature: 38.05 ± 0.73 vs. 36.99 ± 1.02, IL-6: 144.84 ± 23.89 vs. 94.73 ± 5.91, TNF-α: 151.46 ± 46.00 vs. 89.86 ± 13.13, SP-D: 33.65 ± 8.66 vs. 16.63 ± 5.61, MAP: 85.47 ± 9.24 vs. 102.43 ± 8.38, CCI: 3.00 ± 0.48 vs. 3.81 ± 0.81, OI: 62.00 ± 21.45 vs. 103.40 ± 37.27, C: 32.10 ± 2.92 vs. 49.57 ± 7.18, all P safety and usability.

  14. Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Carla M. Teglia

    2015-10-01

    Full Text Available An efficient generic static headspace gas chromatography (HSGC method was developed, optimized and validated for the routine determination of several residual solvents (RS in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide (DMSO was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step. A gas chromatograph from Agilent Model 6890 equipped with flame ionization detector (FID and a DB-624 (30 m×0.53 mm i.d., 3.00 µm film thickness column was used. The inlet split ratio was 5:1. The influencing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design. Significant variables: the initial temperature (IT, the final temperature (FT of the oven and the carrier gas flow rate (F were optimized using a central composite design. Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time. These conditions were 30 °C for IT, 158 °C for FT and 1.90 mL/min for F. The method was proven to be accurate, linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines. Keywords: Headspace gas chromatography, Residual solvents, Pharmaceuticals, Surface response methodology, Desirability function

  15. Design Optimization of Cyber-Physical Distributed Systems using IEEE Time-sensitive Networks (TSN)

    DEFF Research Database (Denmark)

    Pop, Paul; Lander Raagaard, Michael; Craciunas, Silviu S.

    2016-01-01

    to the optimization of distributed cyber-physical systems using real-time Ethernet for communication. Then, we formulate two novel optimization problems related to the scheduling and routing of TT and AVB traffic in TSN. Thus, we consider that we know the topology of the network as well as the set of TT and AVB flows......In this paper we are interested in safety-critical real-time applications implemented on distributed architectures supporting the Time-SensitiveNetworking (TSN) standard. The ongoing standardization of TSN is an IEEE effort to bring deterministic real-time capabilities into the IEEE 802.1 Ethernet...... standard supporting safety-critical systems and guaranteed Quality-of-Service. TSN will support Time-Triggered (TT) communication based on schedule tables, Audio-Video-Bridging (AVB) flows with bounded end-to-end latency as well as Best-Effort messages. We first present a survey of research related...

  16. Uso de equações diferenciais para determinação do momento ótimo da transformação de veículos The use of differential equations for the determination of the optimal time for the trasformation of vehicles

    Directory of Open Access Journals (Sweden)

    Gláucio Marcelino Marques

    2005-02-01

    Full Text Available Este trabalho teve por objetivo analisar a viabilidade econômica da transformação de veículos de transporte florestal. Foram avaliadas duas situações: 1ª carreta utilizada e retirada do processo após o fim de sua vida útil; 2ª carreta utilizada, transformada em caminhão truck e, posteriormente, em caminhão toco. A equação diferencial foi utilizada para definir o momento ótimo das transformações. Os resultados obtidos indicaram que, no modelo sem transformação, obteve-se um tempo ótimo de utilização de nove anos, apresentando um Valor Anual Equivalente (VAE de R$4.084,06. No modelo com transformação (carreta/truck/toco, obteve-se um (VAE de R$10.555,04, indicando a viabilidade no sistema de transformação. Com base nos dados de custo e receita utilizados, a transformação (carreta/truck/toco mostrou-se a melhor alternativa. Conclui-se que os modelos desenvolvidos permitem auxiliar a tomada de decisão referente à substituição de veículos de transporte.The objective of this work was to analyse the economic feasibility of the transformation of forest transport vehicles. Two situations were evaluated; in one the cart was used and removed after its useful lifetime, in the other one the cart is transformed in to truck and, finally, in to a two-wheeled cart. The differential equation was used to define the optimal time of the transformations. The results obtained showed that in the model without transformation an optimal time nine years used was defined, presenting an Equivalent Annual Value of R$4,084.06. In the model with transformation (cart/truck/two-wheeled cart, an Equivalent Annual Value of R$10,555.04 was obtained, indicating the viability of the transformation system. Based on data of costs and incomes used the transformation (cart/truck/two-wheeled cart showed to be best alternative. It follows that the models developed showed to be suitable in supporting the decision making related to the replacement of

  17. Multiobjective Optimization for Electronic Circuit Design in Time and Frequency Domains

    Directory of Open Access Journals (Sweden)

    J. Dobes

    2013-04-01

    Full Text Available The multiobjective optimization provides an extraordinary opportunity for the finest design of electronic circuits because it allows to mathematically balance contradictory requirements together with possible constraints. In this paper, an original and substantial improvement of an existing method for the multiobjective optimization known as GAM (Goal Attainment Method is suggested. In our proposal, the GAM algorithm itself is combined with a procedure that automatically provides a set of parameters -- weights, coordinates of the reference point -- for which the method generates noninferior solutions uniformly spread over an appropriately selected part of the Pareto front. Moreover, the resulting set of obtained solutions is then presented in a suitable graphic form so that the solution representing the most satisfactory tradeoff can be easily chosen by the designer. Our system generates various types of plots that conveniently characterize results of up to four-dimensional problems. Technically, the procedures of the multiobjective optimization were created as a software add-on to the CIA (Circuit Interactive Analyzer program. This way enabled us to utilize many powerful features of this program, including the sensitivity analyses in time and frequency domains. As a result, the system is also able to perform the multiobjective optimization in the time domain and even highly nonlinear circuits can be significantly improved by our program. As a demonstration of this feature, a multiobjective optimization of a C-class power amplifier in the time domain is thoroughly described in the paper. Further, a four-dimensional optimization of a video amplifier is demonstrated with an original graphic representation of the Pareto front, and also some comparison with the weighting method is done. As an example of improving noise properties, a multiobjective optimization of a low-noise amplifier is performed, and the results in the frequency domain are shown

  18. Acceleration optimization of real-time equilibrium reconstruction for HL-2A tokamak discharge control

    Science.gov (United States)

    Rui, MA; Fan, XIA; Fei, LING; Jiaxian, LI

    2018-02-01

    Real-time equilibrium reconstruction is crucially important for plasma shape control in the process of tokamak plasma discharge. However, as the reconstruction algorithm is computationally intensive, it is very difficult to improve its accuracy and reduce the computation time, and some optimizations need to be done. This article describes the three most important aspects of this optimization: (1) compiler optimization; (2) some optimization for middle-scale matrix multiplication on the graphic processing unit and an algorithm which can solve the block tri-diagonal linear system efficiently in parallel; (3) a new algorithm to locate the X&O point on the central processing unit. A static test proves the correctness and a dynamic test proves the feasibility of using the new code for real-time reconstruction with 129 × 129 grids; it can complete one iteration around 575 μs for each equilibrium reconstruction. The plasma displacements from real-time equilibrium reconstruction are compared with the experimental measurements, and the calculated results are consistent with the measured ones, which can be used as a reference for the real-time control of HL-2A discharge.

  19. Determination of optimal geometry for cylindrical sources for gamma radiation measurements; Odredjivanje optimalne geometrije za mjerenje gama zracenja cilindrichnih izvora

    Energy Technology Data Exchange (ETDEWEB)

    Sinjeri, Lj; Kulisic, P [Elektra - Zagreb, Zagreb (Yugoslavia)

    1990-07-01

    Low radioactive sources were used for experimental determination of optimal dimensions for cylindrical source using coaxial Ge(Li) detector. Then, calculational procedure is used to find optimal dimensions of cylindrical source. The results from calculational procedure confirm with experimental results. In such way the verification of calculational procedure is done and it can be used for determination of optimal geometry for low radioactive cylindrical sources. (author)

  20. Determining optimal selling price and lot size with process reliability and partial backlogging considerations

    Science.gov (United States)

    Hsieh, Tsu-Pang; Cheng, Mei-Chuan; Dye, Chung-Yuan; Ouyang, Liang-Yuh

    2011-01-01

    In this article, we extend the classical economic production quantity (EPQ) model by proposing imperfect production processes and quality-dependent unit production cost. The demand rate is described by any convex decreasing function of the selling price. In addition, we allow for shortages and a time-proportional backlogging rate. For any given selling price, we first prove that the optimal production schedule not only exists but also is unique. Next, we show that the total profit per unit time is a concave function of price when the production schedule is given. We then provide a simple algorithm to find the optimal selling price and production schedule for the proposed model. Finally, we use a couple of numerical examples to illustrate the algorithm and conclude this article with suggestions for possible future research.

  1. Optimized Scheduling of Smart Meter Data Access for Real-time Voltage Quality Monitoring

    DEFF Research Database (Denmark)

    Kemal, Mohammed Seifu; Olsen, Rasmus Løvenstein; Schwefel, Hans-Peter

    2018-01-01

    Abstract—Active low-voltage distribution grids that support high integration of distributed generation such as photovoltaics and wind turbines require real-time voltage monitoring. At the same time, countries in Europe such as Denmark have close to 100% rollout of smart metering infrastructure....... The metering infrastructure has limitations to provide real-time measurements with small-time granularity. This paper presents an algorithm for optimized scheduling of smart meter data access to provide real-time voltage quality monitoring. The algorithm is analyzed using a real distribution grid in Denmark...

  2. A new power mapping method based on ordinary kriging and determination of optimal detector location strategy

    International Nuclear Information System (INIS)

    Peng, Xingjie; Wang, Kan; Li, Qing

    2014-01-01

    Highlights: • A new power mapping method based on Ordinary Kriging (OK) is proposed. • Measurements from DayaBay Unit 1 PWR are used to verify the OK method. • The OK method performs better than the CECOR method. • An optimal neutron detector location strategy based on ordinary kriging and simulated annealing is proposed. - Abstract: The Ordinary Kriging (OK) method is presented that is designed for a core power mapping calculation of pressurized water reactors (PWRs). Measurements from DayaBay Unit 1 PWR are used to verify the accuracy of the OK method. The root mean square (RMS) reconstruction errors are kept at less than 0.35%, and the maximum reconstruction relative errors (RE) are kept at less than 1.02% for the entire operating cycle. The reconstructed assembly power distribution results show that the OK method is fit for core power distribution monitoring. The quality of power distribution obtained by the OK method is partly determined by the neutron detector locations, and the OK method is also applied to solve the optimal neutron detector location problem. The spatially averaged ordinary kriging variance (AOKV) is minimized using simulated annealing, and then, the optimal in-core neutron detector locations are obtained. The result shows that the current neutron detector location of DayaBay Unit 1 reactor is near-optimal

  3. Determining Time Variation of Cable Tension Forces in Suspended Bridges Using Time-Frequency Analysis

    Directory of Open Access Journals (Sweden)

    Gannon Stromquist-LeVoir

    2018-01-01

    Full Text Available A feasibility study was conducted to develop a novel method to determine the temporal changes of tensile forces in bridge suspender cables using time-frequency analysis of ambient vibration measurements. An analytical model of the suspender cables was developed to evaluate the power spectral density (PSD function of a cable with consideration of cable flexural stiffness. Discrete-time, short-time Fourier transform (STFT was utilized to analyze the recorded acceleration histories in both time and frequency domains. A mathematical convolution of the analytical PSD function and time-frequency data was completed to evaluate changes in cable tension force over time. The method was implemented using acceleration measurements collected from an in-service steel arch bridge with a suspended deck to calculate the temporal variation in cable forces from the vibration measurements. The observations served as proof of concept that the proposed method may be used for cable fatigue life calculations and bridge weigh-in-motion studies.

  4. A Method of Signal Timing Optimization for Spillover Dissipation in Urban Street Networks

    Directory of Open Access Journals (Sweden)

    Dongfang Ma

    2013-01-01

    Full Text Available The precise identification and quick dissipation of spillovers are critically important in a traffic control system, especially when heavy congestion occurs. This paper first presents a calculation method for the occupancy per cycle under different traffic conditions and identifies the threshold of occupancy that characterizes the formation of spillovers. Then, capacity adjustments are determined for the incoming and outgoing streams of bottleneck links, with the aim of dissipating the queue to a permissible length within a given period of time, and optimization schemes are defined to calculate splits for the upstream and downstream intersections. Finally, taking average vehicular delay, outputs per cycle, and maximum queue length on the bottleneck link as the evaluation indices, the method of dissipating spillovers proposed in this paper is evaluated using a VISSIM simulation. The results show that the maximum queue length on the bottleneck link and the average vehicular delay at the upstream and downstream intersections decrease significantly under the new signal control plan; meanwhile, the new control schemes have little influence on the outputs of the two intersections per cycle.

  5. Expert system and process optimization techniques for real-time monitoring and control of plasma processes

    Science.gov (United States)

    Cheng, Jie; Qian, Zhaogang; Irani, Keki B.; Etemad, Hossein; Elta, Michael E.

    1991-03-01

    To meet the ever-increasing demand of the rapidly-growing semiconductor manufacturing industry it is critical to have a comprehensive methodology integrating techniques for process optimization real-time monitoring and adaptive process control. To this end we have accomplished an integrated knowledge-based approach combining latest expert system technology machine learning method and traditional statistical process control (SPC) techniques. This knowledge-based approach is advantageous in that it makes it possible for the task of process optimization and adaptive control to be performed consistently and predictably. Furthermore this approach can be used to construct high-level and qualitative description of processes and thus make the process behavior easy to monitor predict and control. Two software packages RIST (Rule Induction and Statistical Testing) and KARSM (Knowledge Acquisition from Response Surface Methodology) have been developed and incorporated with two commercially available packages G2 (real-time expert system) and ULTRAMAX (a tool for sequential process optimization).

  6. Hard and soft sub-time-optimal controllers for a mechanical system with uncertain mass

    DEFF Research Database (Denmark)

    Kulczycki, P.; Wisniewski, Rafal; Kowalski, P.

    2004-01-01

    An essential limitation in using the classical optimal control has been its limited robustness to modeling inadequacies and perturbations. This paper presents conceptions of two practical control structures based on the time-optimal approach: hard and soft ones. The hard structure is defined...... by parameters selected in accordance with the rules of the statistical decision theory; however, the soft structure allows additionally to eliminate rapid changes in control values. The object is a basic mechanical system, with uncertain (also non-stationary) mass treated as a stochastic process....... The methodology proposed here is of a universal nature and may easily be applied with respect to other elements of uncertainty of time-optimal controlled mechanical systems....

  7. Hard and soft Sub-Time-Optimal Controllers for a Mechanical System with Uncertain Mass

    DEFF Research Database (Denmark)

    Kulczycki, P.; Wisniewski, Rafal; Kowalski, P.

    2005-01-01

    An essential limitation in using the classical optimal control has been its limited robustness to modeling inadequacies and perturbations. This paper presents conceptions of two practical control structures based on the time-optimal approach: hard and soft ones. The hard structure is defined...... by parameters selected in accordance with the rules of the statistical decision theory; however, the soft structure allows additionally to eliminate rapid changes in control values. The object is a basic mechanical system, with uncertain (also non-stationary) mass treated as a stochastic process....... The methodology proposed here is of a universal nature and may easily be applied with respect to other elements of uncertainty of time-optimal controlled mechanical systems....

  8. Time-explicit methods for joint economical and geological risk mitigation in production optimization

    DEFF Research Database (Denmark)

    Christiansen, Lasse Hjuler; Capolei, Andrea; Jørgensen, John Bagterp

    2016-01-01

    Real-life applications of production optimization face challenges of risks related to unpredictable fluctuations in oil prices and sparse geological data. Consequently, operating companies are reluctant to adopt model-based production optimization into their operations. Conventional production...... of mitigating economical and geological risks. As opposed to conventional strategies that focus on a single long-term objective, TE methods seek to reduce risks and promote returns over the entire reservoir life by optimization of a given ensemble-based geological risk measure over time. By explicit involvement...... of time, economical risks are implicitly addressed by balancing short-term and long-term objectives throughout the reservoir life. Open-loop simulations of a two-phase synthetic reservoir demonstrate that TE methods may significantly improve short-term risk measures such as expected return, standard...

  9. Space-time topology optimization for one-dimensional wave propagation

    DEFF Research Database (Denmark)

    Jensen, Jakob Søndergaard

    2009-01-01

    -dimensional transient wave propagation in an elastic rod with time dependent Young's modulus. By two simulation examples it is demonstrated how dynamic structures can display rich dynamic behavior such as wavenumber/frequency shifts and lack of energy conservation. The optimization method's potential for creating...... structures with novel dynamic behavior is illustrated by a simple example; it is shown that an elastic rod in which the optimized stiffness distribution is allowed to vary in time can be much more efficient in prohibiting wave propagation compared to a static bandgap structure. Optimized designs in form...... of spatio-temporal laminates and checkerboards are generated and discussed. The example lays the foundation for creating designs with more advanced functionalities in future work....

  10. Road maintenance optimization through a discrete-time semi-Markov decision process

    International Nuclear Information System (INIS)

    Zhang Xueqing; Gao Hui

    2012-01-01

    Optimization models are necessary for efficient and cost-effective maintenance of a road network. In this regard, road deterioration is commonly modeled as a discrete-time Markov process such that an optimal maintenance policy can be obtained based on the Markov decision process, or as a renewal process such that an optimal maintenance policy can be obtained based on the renewal theory. However, the discrete-time Markov process cannot capture the real time at which the state transits while the renewal process considers only one state and one maintenance action. In this paper, road deterioration is modeled as a semi-Markov process in which the state transition has the Markov property and the holding time in each state is assumed to follow a discrete Weibull distribution. Based on this semi-Markov process, linear programming models are formulated for both infinite and finite planning horizons in order to derive optimal maintenance policies to minimize the life-cycle cost of a road network. A hypothetical road network is used to illustrate the application of the proposed optimization models. The results indicate that these linear programming models are practical for the maintenance of a road network having a large number of road segments and that they are convenient to incorporate various constraints on the decision process, for example, performance requirements and available budgets. Although the optimal maintenance policies obtained for the road network are randomized stationary policies, the extent of this randomness in decision making is limited. The maintenance actions are deterministic for most states and the randomness in selecting actions occurs only for a few states.

  11. Determination of radial profile of ICF hot spot's state by multi-objective parameters optimization

    International Nuclear Information System (INIS)

    Dong Jianjun; Deng Bo; Cao Zhurong; Ding Yongkun; Jiang Shaoen

    2014-01-01

    A method using multi-objective parameters optimization is presented to determine the radial profile of hot spot temperature and density. And a parameter space which contain five variables: the temperatures at center and the interface of fuel and remain ablator, the maximum model density of remain ablator, the mass ratio of remain ablator to initial ablator and the position of interface between fuel and the remain ablator, is used to described the hot spot radial temperature and density. Two objective functions are set as the variances of normalized intensity profile from experiment X-ray images and the theory calculation. Another objective function is set as the variance of experiment average temperature of hot spot and the average temperature calculated by theoretical model. The optimized parameters are obtained by multi-objective genetic algorithm searching for the five dimension parameter space, thereby the optimized radial temperature and density profiles can be determined. The radial temperature and density profiles of hot spot by experiment data measured by KB microscope cooperating with X-ray film are presented. It is observed that the temperature profile is strongly correlated to the objective functions. (authors)

  12. HPLC/DAD determination of rosmarinic acid in Salvia officinalis: sample preparation optimization by factorial design

    International Nuclear Information System (INIS)

    Oliveira, Karina B. de; Oliveira, Bras H. de

    2013-01-01

    Sage (Salvia officinalis) contains high amounts of the biologically active rosmarinic acid (RA) and other polyphenolic compounds. RA is easily oxidized, and may undergo degradation during sample preparation for analysis. The objective of this work was to develop and validate an analytical procedure for determination of RA in sage, using factorial design of experiments for optimizing sample preparation. The statistically significant variables for improving RA extraction yield were determined initially and then used in the optimization step, using central composite design (CCD). The analytical method was then fully validated, and used for the analysis of commercial samples of sage. The optimized procedure involved extraction with aqueous methanol (40%) containing an antioxidant mixture (ascorbic acid and ethylenediaminetetraacetic acid (EDTA)), with sonication at 45 deg C for 20 min. The samples were then injected in a system containing a C 18 column, using methanol (A) and 0.1% phosphoric acid in water (B) in step gradient mode (45A:55B, 0-5 min; 80A:20B, 5-10 min) with flow rate of 1.0 mL min−1 and detection at 330 nm. Using this conditions, RA concentrations were 50% higher when compared to extractions without antioxidants (98.94 ± 1.07% recovery). Auto-oxidation of RA during sample extraction was prevented by the use of antioxidants resulting in more reliable analytical results. The method was then used for the analysis of commercial samples of sage. (author)

  13. HPLC/DAD determination of rosmarinic acid in Salvia officinalis: sample preparation optimization by factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Karina B. de [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Farmacia; Oliveira, Bras H. de, E-mail: bho@ufpr.br [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Quimica

    2013-01-15

    Sage (Salvia officinalis) contains high amounts of the biologically active rosmarinic acid (RA) and other polyphenolic compounds. RA is easily oxidized, and may undergo degradation during sample preparation for analysis. The objective of this work was to develop and validate an analytical procedure for determination of RA in sage, using factorial design of experiments for optimizing sample preparation. The statistically significant variables for improving RA extraction yield were determined initially and then used in the optimization step, using central composite design (CCD). The analytical method was then fully validated, and used for the analysis of commercial samples of sage. The optimized procedure involved extraction with aqueous methanol (40%) containing an antioxidant mixture (ascorbic acid and ethylenediaminetetraacetic acid (EDTA)), with sonication at 45 deg C for 20 min. The samples were then injected in a system containing a C{sub 18} column, using methanol (A) and 0.1% phosphoric acid in water (B) in step gradient mode (45A:55B, 0-5 min; 80A:20B, 5-10 min) with flow rate of 1.0 mL min-1 and detection at 330 nm. Using this conditions, RA concentrations were 50% higher when compared to extractions without antioxidants (98.94 {+-} 1.07% recovery). Auto-oxidation of RA during sample extraction was prevented by the use of antioxidants resulting in more reliable analytical results. The method was then used for the analysis of commercial samples of sage. (author)

  14. Method to determine the optimal constitutive model from spherical indentation tests

    Science.gov (United States)

    Zhang, Tairui; Wang, Shang; Wang, Weiqiang

    2018-03-01

    The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed. Two constitutive models, the Power-law and the Linear-law, were used in Finite Element (FE) calculations, and then a set of indentation governing equations was established for each model. The load-depth data from the normal indentation depth was used to fit the best parameters in each constitutive model while the data from the further loading part was compared with those from FE calculations, and the model that better predicted the further deformation was considered the optimal one. Moreover, a Yang's modulus calculation model which took the previous plastic deformation and the phenomenon of pile-up (or sink-in) into consideration was also proposed to revise the original Sneddon-Pharr-Oliver model. The indentation results on six materials, 304, 321, SA508, SA533, 15CrMoR, and Fv520B, were compared with tensile ones, which validated the reliability of the revised E calculation model and the optimal constitutive model determination method in this study.

  15. Global Time Tomography of Finite Frequency Waves with Optimized Tetrahedral Grids.

    Science.gov (United States)

    Montelli, R.; Montelli, R.; Nolet, G.; Dahlen, F. A.; Masters, G.; Hung, S.

    2001-12-01

    Besides true velocity heterogeneities, tomographic images reflect the effect of data errors, model parametrization, linearization, uncertainties involved with the solution of the forward problem and the greatly inadequate sampling of the earth by seismic rays. These influences cannot be easily separated and often produce artefacts in the final image with amplitudes comparable to those of the velocity heterogeneities. In practice, the tomographer uses some form of damping of the ill-resolved aspects of the model to get a unique solution and reduce the influence of the errors. However damping is not fully adequate, and may reveal a strong influence of the ray path coverage in tomographic images. If some cells are ill determinated regularization techniques may lead to heterogeneity because these cells are damped towards zero. Thus we want a uniform resolution of the parameters in our model. This can be obtained by using an irregular grid with variable length scales. We have introduced an irregular parametrization of the velocity structure by using a Delaunay triangulation. Extensively work on error analysis of tomographic images together with mesh optimization has shown that both resolution and ray density can provide the critical informations needed to re-design grids. However, criteria based on resolution are preferred in the presence of narrow ray beams coming from the same direction. This can be understood if we realise that resolution is not only determined by the number of rays crossing a region, but also by their azimutal coverage. We shall discuss various strategies for grid optimization. In general the computation of the travel times is restricted to ray theory, the infinite frequency approximation of the elastodynamic equation of motion. This simplifies the mathematic and is therefore widely applied in seismic tomography. But ray theory does not account for scattering, wavefront healing and other diffraction effects that render the traveltime of a finite

  16. Optimal decision procedures for satisfiability in fragments of alternating-time temporal logics

    DEFF Research Database (Denmark)

    Goranko, Valentin; Vester, Steen

    2014-01-01

    We consider several natural fragments of the alternating-time temporal logics ATL*and ATL with restrictions on the nesting between temporal operators and strate-gicquantifiers. We develop optimal decision procedures for satisfiability in these fragments, showing that they have much lower complexi...

  17. Economically optimal timing for crop disease control under uncertainty: an options approach

    NARCIS (Netherlands)

    Ndeffo Mbah, M.L.; Forster, G.; Wesseler, J.H.H.; Gilligan, C.A.

    2010-01-01

    Severe large-scale disease and pest infestations in agricultural regions can cause significant economic damage. Understanding if and when disease control measures should be taken in the presence of risk and uncertainty is a key issue. We develop a framework to examine the economically optimal timing

  18. How to study optimal timing of PET/CT for monitoring of cancer treatment

    DEFF Research Database (Denmark)

    Vach, Werner; Høilund-Carlsen, Poul Flemming; Fischer, Barbara Malene Bjerregaard

    2011-01-01

    Purpose: The use of PET/CT for monitoring treatment response in cancer patients after chemo- or radiotherapy is a very promising approach to optimize cancer treatment. However, the timing of the PET/CT-based evaluation of reduction in viable tumor tissue is a crucial question. We investigated how...

  19. Optimizing headspace sampling temperature and time for analysis of volatile oxidation products in fish oil

    DEFF Research Database (Denmark)

    Rørbæk, Karen; Jensen, Benny

    1997-01-01

    Headspace-gas chromatography (HS-GC), based on adsorption to Tenax GR(R), thermal desorption and GC, has been used for analysis of volatiles in fish oil. To optimize sam sampling conditions, the effect of heating the fish oil at various temperatures and times was evaluated from anisidine values (AV...

  20. Shape optimization for non-Newtonian fluids in time-dependent domains

    Czech Academy of Sciences Publication Activity Database

    Sokolowski, J.; Stebel, Jan

    2014-01-01

    Roč. 3, č. 2 (2014), s. 331-348 ISSN 2163-2480 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : shape optimization * time - dependent domain * incompressible viscous fluid Subject RIV: BA - General Mathematics Impact factor: 0.373, year: 2014 http://www.aimsciences.org/journals/home.jsp?journalID=25

  1. Real-time sail and heading optimization for a surface sailing vessel by extremum seeking control

    DEFF Research Database (Denmark)

    Treichel, Kai; Jouffroy, Jerome

    2010-01-01

    In this paper we develop a simplified mathematical model representing the main elements of the behaviour of sailing vessels as a basis for simulation and controller design. For adaptive real-time optimization of the sail and heading angle we then apply extremum seeking control (which is a gradient...

  2. Optimal One Bit Time Reversal For UWB Impulse Radio In Multi-User Wireless Communications

    DEFF Research Database (Denmark)

    Nguyen, Hung Tuan

    2008-01-01

    In this paper, with the purpose of further reducing the complexity of the system, while keeping its temporal and spatial focusing performance, we investigate the possibility of using optimal one bit time reversal (TR) system for impulse radio ultra wideband multi-user wireless communications...

  3. LMI optimization approach to stabilization of time-delay chaotic systems

    International Nuclear Information System (INIS)

    Park, Ju H.; Kwon, O.M.

    2005-01-01

    Based on the Lyapunov stability theory and linear matrix inequality (LMI) technique, this paper proposes a novel control method for stabilization of a class of time-delay chaotic systems. A stabilization criterion is derived in terms of LMIs which can be easily solved by efficient convex optimization algorithms. A numerical example is included to show the advantage of the result derived

  4. Methods for providing decision makers with optimal solutions for multiple objectives that change over time

    CSIR Research Space (South Africa)

    Greeff, M

    2010-09-01

    Full Text Available Decision making - with the goal of finding the optimal solution - is an important part of modern life. For example: In the control room of an airport, the goals or objectives are to minimise the risk of airplanes colliding, minimise the time that a...

  5. Prospective Teachers' Future Time Perspective and Professional Plans about Teaching: The Mediating Role of Academic Optimism

    Science.gov (United States)

    Eren, Altay

    2012-01-01

    This study aimed to examine the mediating role of prospective teachers' academic optimism in the relationship between their future time perspective and professional plans about teaching. A total of 396 prospective teachers voluntarily participated in the study. Correlation, regression, and structural equation modeling analyses were conducted in…

  6. Real-time Terrain Rendering using Smooth Hardware Optimized Level of Detail

    DEFF Research Database (Denmark)

    Larsen, Bent Dalgaard; Christensen, Niels Jørgen

    2003-01-01

    We present a method for real-time level of detail reduction that is able to display high-complexity polygonal surface data. A compact and efficient regular grid representation is used. The method is optimized for modern, low-end consumer 3D graphics cards. We avoid sudden changes of the geometry...

  7. Genetic algorithm for project time-cost optimization in fuzzy environment

    Directory of Open Access Journals (Sweden)

    Khan Md. Ariful Haque

    2012-12-01

    Full Text Available Purpose: The aim of this research is to develop a more realistic approach to solve project time-cost optimization problem under uncertain conditions, with fuzzy time periods. Design/methodology/approach: Deterministic models for time-cost optimization are never efficient considering various uncertainty factors. To make such problems realistic, triangular fuzzy numbers and the concept of a-cut method in fuzzy logic theory are employed to model the problem. Because of NP-hard nature of the project scheduling problem, Genetic Algorithm (GA has been used as a searching tool. Finally, Dev-C++ 4.9.9.2 has been used to code this solver. Findings: The solution has been performed under different combinations of GA parameters and after result analysis optimum values of those parameters have been found for the best solution. Research limitations/implications: For demonstration of the application of the developed algorithm, a project on new product (Pre-paid electric meter, a project under government finance launching has been chosen as a real case. The algorithm is developed under some assumptions. Practical implications: The proposed model leads decision makers to choose the desired solution under different risk levels. Originality/value: Reports reveal that project optimization problems have never been solved under multiple uncertainty conditions. Here, the function has been optimized using Genetic Algorithm search technique, with varied level of risks and fuzzy time periods.

  8. Overlapping quadratic optimal control of linear time-varying commutative systems

    Czech Academy of Sciences Publication Activity Database

    Bakule, Lubomír; Rodellar, J.; Rossell, J. M.

    2002-01-01

    Roč. 40, č. 5 (2002), s. 1611-1627 ISSN 0363-0129 R&D Projects: GA AV ČR IAA2075802 Institutional research plan: CEZ:AV0Z1075907 Keywords : overlapping * optimal control * linear time-varying systems Subject RIV: BC - Control Systems Theory Impact factor: 1.441, year: 2002

  9. Starting ART following cryptococcal meningitis:The optimal time has yet to be defined

    Directory of Open Access Journals (Sweden)

    T A Bicanic

    2013-09-01

    Full Text Available Ever since the public sector rollout of antiretroviral therapy (ART in 2004, the question of the optimal time to start ART following diagnosis of an opportunistic infection has aroused controversy among South African HIV clinicians and researchers.

  10. Reducing acquisition times in multidimensional NMR with a time-optimized Fourier encoding algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhiyong [Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 (Israel); Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005 (China); Smith, Pieter E. S.; Frydman, Lucio, E-mail: lucio.frydman@weizmann.ac.il [Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 (Israel)

    2014-11-21

    Speeding up the acquisition of multidimensional nuclear magnetic resonance (NMR) spectra is an important topic in contemporary NMR, with central roles in high-throughput investigations and analyses of marginally stable samples. A variety of fast NMR techniques have been developed, including methods based on non-uniform sampling and Hadamard encoding, that overcome the long sampling times inherent to schemes based on fast-Fourier-transform (FFT) methods. Here, we explore the potential of an alternative fast acquisition method that leverages a priori knowledge, to tailor polychromatic pulses and customized time delays for an efficient Fourier encoding of the indirect domain of an NMR experiment. By porting the encoding of the indirect-domain to the excitation process, this strategy avoids potential artifacts associated with non-uniform sampling schemes and uses a minimum number of scans equal to the number of resonances present in the indirect dimension. An added convenience is afforded by the fact that a usual 2D FFT can be used to process the generated data. Acquisitions of 2D heteronuclear correlation NMR spectra on quinine and on the anti-inflammatory drug isobutyl propionic phenolic acid illustrate the new method's performance. This method can be readily automated to deal with complex samples such as those occurring in metabolomics, in in-cell as well as in in vivo NMR applications, where speed and temporal stability are often primary concerns.

  11. Reducing acquisition times in multidimensional NMR with a time-optimized Fourier encoding algorithm

    International Nuclear Information System (INIS)

    Zhang, Zhiyong; Smith, Pieter E. S.; Frydman, Lucio

    2014-01-01

    Speeding up the acquisition of multidimensional nuclear magnetic resonance (NMR) spectra is an important topic in contemporary NMR, with central roles in high-throughput investigations and analyses of marginally stable samples. A variety of fast NMR techniques have been developed, including methods based on non-uniform sampling and Hadamard encoding, that overcome the long sampling times inherent to schemes based on fast-Fourier-transform (FFT) methods. Here, we explore the potential of an alternative fast acquisition method that leverages a priori knowledge, to tailor polychromatic pulses and customized time delays for an efficient Fourier encoding of the indirect domain of an NMR experiment. By porting the encoding of the indirect-domain to the excitation process, this strategy avoids potential artifacts associated with non-uniform sampling schemes and uses a minimum number of scans equal to the number of resonances present in the indirect dimension. An added convenience is afforded by the fact that a usual 2D FFT can be used to process the generated data. Acquisitions of 2D heteronuclear correlation NMR spectra on quinine and on the anti-inflammatory drug isobutyl propionic phenolic acid illustrate the new method's performance. This method can be readily automated to deal with complex samples such as those occurring in metabolomics, in in-cell as well as in in vivo NMR applications, where speed and temporal stability are often primary concerns

  12. Optimal distribution of integration time for intensity measurements in degree of linear polarization polarimetry.

    Science.gov (United States)

    Li, Xiaobo; Hu, Haofeng; Liu, Tiegen; Huang, Bingjing; Song, Zhanjie

    2016-04-04

    We consider the degree of linear polarization (DOLP) polarimetry system, which performs two intensity measurements at orthogonal polarization states to estimate DOLP. We show that if the total integration time of intensity measurements is fixed, the variance of the DOLP estimator depends on the distribution of integration time for two intensity measurements. Therefore, by optimizing the distribution of integration time, the variance of the DOLP estimator can be decreased. In this paper, we obtain the closed-form solution of the optimal distribution of integration time in an approximate way by employing Delta method and Lagrange multiplier method. According to the theoretical analyses and real-world experiments, it is shown that the variance of the DOLP estimator can be decreased for any value of DOLP. The method proposed in this paper can effectively decrease the measurement variance and thus statistically improve the measurement accuracy of the polarimetry system.

  13. Optimal distribution of integration time for intensity measurements in Stokes polarimetry.

    Science.gov (United States)

    Li, Xiaobo; Liu, Tiegen; Huang, Bingjing; Song, Zhanjie; Hu, Haofeng

    2015-10-19

    We consider the typical Stokes polarimetry system, which performs four intensity measurements to estimate a Stokes vector. We show that if the total integration time of intensity measurements is fixed, the variance of the Stokes vector estimator depends on the distribution of the integration time at four intensity measurements. Therefore, by optimizing the distribution of integration time, the variance of the Stokes vector estimator can be decreased. In this paper, we obtain the closed-form solution of the optimal distribution of integration time by employing Lagrange multiplier method. According to the theoretical analysis and real-world experiment, it is shown that the total variance of the Stokes vector estimator can be significantly decreased about 40% in the case discussed in this paper. The method proposed in this paper can effectively decrease the measurement variance and thus statistically improves the measurement accuracy of the polarimetric system.

  14. The Optimization of Transportation Costs in Logistics Enterprises with Time-Window Constraints

    Directory of Open Access Journals (Sweden)

    Qingyou Yan

    2015-01-01

    Full Text Available This paper presents a model for solving a multiobjective vehicle routing problem with soft time-window constraints that specify the earliest and latest arrival times of customers. If a customer is serviced before the earliest specified arrival time, extra inventory costs are incurred. If the customer is serviced after the latest arrival time, penalty costs must be paid. Both the total transportation cost and the required fleet size are minimized in this model, which also accounts for the given capacity limitations of each vehicle. The total transportation cost consists of direct transportation costs, extra inventory costs, and penalty costs. This multiobjective optimization is solved by using a modified genetic algorithm approach. The output of the algorithm is a set of optimal solutions that represent the trade-off between total transportation cost and the fleet size required to service customers. The influential impact of these two factors is analyzed through the use of a case study.

  15. Optimizing Completion Time and Energy Consumption in a Bidirectional Relay Network

    DEFF Research Database (Denmark)

    Liu, Huaping; Sun, Fan; Thai, Chan

    2012-01-01

    consumption required for multiple flows depends on the current channel realizations, transmission methods used and, notably, the relation between the data sizes of different source nodes. In this paper we investigate the shortest completion time and minimal energy consumption in a two-way relay wireless...... arises for the minimal required energy. While the requirement for minimal energy consumption is obvious, the shortest completion time is relevant when certain multi-node network needs to reserve the wireless medium in order to carry out the data exchange among its nodes. The completion time/energy...... network. The system applies optimal time multiplexing of several known transmission methods, including one-way relaying and wireless network coding (WNC). We show that when the relay applies Amplify-and-Forward (AF), both minimizations are linear optimization problems. On the other hand, when the relay...

  16. Communication: Time-dependent optimized coupled-cluster method for multielectron dynamics

    Science.gov (United States)

    Sato, Takeshi; Pathak, Himadri; Orimo, Yuki; Ishikawa, Kenichi L.

    2018-02-01

    Time-dependent coupled-cluster method with time-varying orbital functions, called time-dependent optimized coupled-cluster (TD-OCC) method, is formulated for multielectron dynamics in an intense laser field. We have successfully derived the equations of motion for CC amplitudes and orthonormal orbital functions based on the real action functional, and implemented the method including double excitations (TD-OCCD) and double and triple excitations (TD-OCCDT) within the optimized active orbitals. The present method is size extensive and gauge invariant, a polynomial cost-scaling alternative to the time-dependent multiconfiguration self-consistent-field method. The first application of the TD-OCC method of intense-laser driven correlated electron dynamics in Ar atom is reported.

  17. Optimal Compensation with Hidden Action and Lump-Sum Payment in a Continuous-Time Model

    International Nuclear Information System (INIS)

    Cvitanic, Jaksa; Wan, Xuhu; Zhang Jianfeng

    2009-01-01

    We consider a problem of finding optimal contracts in continuous time, when the agent's actions are unobservable by the principal, who pays the agent with a one-time payoff at the end of the contract. We fully solve the case of quadratic cost and separable utility, for general utility functions. The optimal contract is, in general, a nonlinear function of the final outcome only, while in the previously solved cases, for exponential and linear utility functions, the optimal contract is linear in the final output value. In a specific example we compute, the first-best principal's utility is infinite, while it becomes finite with hidden action, which is increasing in value of the output. In the second part of the paper we formulate a general mathematical theory for the problem. We apply the stochastic maximum principle to give necessary conditions for optimal contracts. Sufficient conditions are hard to establish, but we suggest a way to check sufficiency using non-convex optimization

  18. A New Method for Optimal Regularization Parameter Determination in the Inverse Problem of Load Identification

    Directory of Open Access Journals (Sweden)

    Wei Gao

    2016-01-01

    Full Text Available According to the regularization method in the inverse problem of load identification, a new method for determining the optimal regularization parameter is proposed. Firstly, quotient function (QF is defined by utilizing the regularization parameter as a variable based on the least squares solution of the minimization problem. Secondly, the quotient function method (QFM is proposed to select the optimal regularization parameter based on the quadratic programming theory. For employing the QFM, the characteristics of the values of QF with respect to the different regularization parameters are taken into consideration. Finally, numerical and experimental examples are utilized to validate the performance of the QFM. Furthermore, the Generalized Cross-Validation (GCV method and the L-curve method are taken as the comparison methods. The results indicate that the proposed QFM is adaptive to different measuring points, noise levels, and types of dynamic load.

  19. Parametrical Method for Determining Optimal Ship Carrying Capacity and Performance of Handling Equipment

    Directory of Open Access Journals (Sweden)

    Michalski Jan P.

    2016-04-01

    Full Text Available The paper presents a method of evaluating the optimal value of the cargo ships deadweight and the coupled optimal value of cargo handling capacity. The method may be useful at the stage of establishing the main owners requirements concerning the ship design parameters as well as for choosing a proper second hand ship for a given transportation task. The deadweight and the capacity are determined on the basis of a selected economic measure of the transport effectiveness of ship – the Required Freight Rate. The mathematical model of the problem is of a deterministic character and the simplifying assumptions are justified for ships operating in the liner trade. The assumptions are so selected that solution of the problem is obtained in analytical closed form. The presented method can be useful for application in the preliminary ship design or in the simulation of pre-investment transportation task studies.

  20. Determination of the Optimal Exchange Rate Via Control of the Domestic Interest Rate in Nigeria

    Directory of Open Access Journals (Sweden)

    Virtue U. Ekhosuehi

    2014-01-01

    Full Text Available An economic scenario has been considered where the government seeks to achieve a favourable balance-of-payments over a fixed planning horizon through exchange rate policy and control of the domestic interest rate. The dynamics of such an economy was considered in terms of a bounded optimal control problem where the exchange rate is the state variable and the domestic interest rate is the control variable. The idea of balance-of-payments was used as a theoretical underpinning to specify the objective function. By assuming that, changes in exchange rates were induced by two effects: the impact of the domestic interest rate on the exchange rate and the exchange rate system adopted by the government. Instances for both fixed and flexible optimal exchange rate regimes have been determined. The use of the approach has been illustrated employing data obtained from the Central Bank of Nigeria (CBN statistical bulletin. (original abstract

  1. Determining an energy-optimal thermal management strategy for electric driven vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Suchaneck, Andre; Probst, Tobias; Puente Leon, Fernando [Karlsruher Institut fuer Technology (KIT), Karlsruhe (Germany). Inst. of Industrial Information Technology (IIIT)

    2012-11-01

    In electric, hybrid electric and fuel cell vehicles, thermal management may have a significant impact on vehicle range. Therefore, optimal thermal management strategies are required. In this paper a method for determining an energy-optimal control strategy for thermal power generation in electric driven vehicles is presented considering all controlled devices (pumps, valves, fans, and the like) as well as influences like ambient temperature, vehicle speed, motor and battery and cooling cycle temperatures. The method is designed to be generic to increase the thermal management development process speed and to achieve the maximal energy reduction for any electric driven vehicle (e.g., by waste heat utilization). Based on simulations of a prototype electric vehicle with an advanced cooling cycle structure, the potential of the method is shown. (orig.)

  2. Optimized effective potential in real time: Problems and prospects in time-dependent density-functional theory

    International Nuclear Information System (INIS)

    Mundt, Michael; Kuemmel, Stephan

    2006-01-01

    The integral equation for the time-dependent optimized effective potential (TDOEP) in time-dependent density-functional theory is transformed into a set of partial-differential equations. These equations only involve occupied Kohn-Sham orbitals and orbital shifts resulting from the difference between the exchange-correlation potential and the orbital-dependent potential. Due to the success of an analog scheme in the static case, a scheme that propagates orbitals and orbital shifts in real time is a natural candidate for an exact solution of the TDOEP equation. We investigate the numerical stability of such a scheme. An approximation beyond the Krieger-Li-Iafrate approximation for the time-dependent exchange-correlation potential is analyzed

  3. The Optimal Timing of Strategic Action – A Real Options Approach

    Directory of Open Access Journals (Sweden)

    Gordon G. Sollars

    2012-01-01

    Full Text Available he possibility of a first-mover advantage arises in a variety of strategic choices, including product introductions, business start-ups, and mergers and acquisitions. The strategic management literature reflects ambiguity regarding the likelihood that a first mover can or will capture additional value. This paper uses a real options approach to address the optimal timing of strategic moves. Previous studies have modeled real options using either a perpetual or a European financial option. With these models, a strategic choice could only be made either without respect to a time frame (perpetual or at a fixed point in time (European option. Neither case is realistic. Companies typically have strategic options with only a limited time frame due to market factors, but companies may choose to act at any time within that constraint. To reflect this reality, we adapt a method for valuing an American financial option on a dividend paying stock to the real options context. The method presented in this paper proposes a solution for the optimum value for a project that should trigger a strategic choice, and highlights the value lost by not acting optimally. We use simulation results to show that the time frame available to make a strategic choice has an important effect on both the project value for when action should be taken, as well as on the value of waiting to invest at the optimal time. The results presented in this paper help to clarify the ambiguity that is found in the strategic management literature regarding the possibility of obtaining a first-mover advantage. Indeed, a first mover that acts sub-optimally could incur losses or at least not gain any advantage. A first mover that waits to invest at the right time based on the superior information supplied by models based on real options could be better positioned to obtain the benefits that might come from the first move.

  4. Real-Time Inverse Optimal Neural Control for Image Based Visual Servoing with Nonholonomic Mobile Robots

    Directory of Open Access Journals (Sweden)

    Carlos López-Franco

    2015-01-01

    Full Text Available We present an inverse optimal neural controller for a nonholonomic mobile robot with parameter uncertainties and unknown external disturbances. The neural controller is based on a discrete-time recurrent high order neural network (RHONN trained with an extended Kalman filter. The reference velocities for the neural controller are obtained with a visual sensor. The effectiveness of the proposed approach is tested by simulations and real-time experiments.

  5. Time efficient optimization of instance based problems with application to tone onset detection

    OpenAIRE

    Bauer, Nadja; Friedrichs, Klaus; Weihs, Claus

    2016-01-01

    A time efficient optimization technique for instance based problems is proposed, where for each parameter setting the target function has to be evaluated on a large set of problem instances. Computational time is reduced by beginning with a performance estimation based on the evaluation of a representative subset of instances. Subsequently, only promising settings are evaluated on the whole data set. As application a comprehensive music onset detection algorithm is introduce...

  6. Optimal testing input sets for reduced diagnosis time of nuclear power plant digital electronic circuits

    International Nuclear Information System (INIS)

    Kim, D.S.; Seong, P.H.

    1994-01-01

    This paper describes the optimal testing input sets required for the fault diagnosis of the nuclear power plant digital electronic circuits. With the complicated systems such as very large scale integration (VLSI), nuclear power plant (NPP), and aircraft, testing is the major factor of the maintenance of the system. Particularly, diagnosis time grows quickly with the complexity of the component. In this research, for reduce diagnosis time the authors derived the optimal testing sets that are the minimal testing sets required for detecting the failure and for locating of the failed component. For reduced diagnosis time, the technique presented by Hayes fits best for the approach to testing sets generation among many conventional methods. However, this method has the following disadvantages: (a) it considers only the simple network (b) it concerns only whether the system is in failed state or not and does not provide the way to locate the failed component. Therefore the authors have derived the optimal testing input sets that resolve these problems by Hayes while preserving its advantages. When they applied the optimal testing sets to the automatic fault diagnosis system (AFDS) which incorporates the advanced fault diagnosis method of artificial intelligence technique, they found that the fault diagnosis using the optimal testing sets makes testing the digital electronic circuits much faster than that using exhaustive testing input sets; when they applied them to test the Universal (UV) Card which is a nuclear power plant digital input/output solid state protection system card, they reduced the testing time up to about 100 times

  7. Joint optimization of green vehicle scheduling and routing problem with time-varying speeds

    Science.gov (United States)

    Zhang, Dezhi; Wang, Xin; Ni, Nan; Zhang, Zhuo

    2018-01-01

    Based on an analysis of the congestion effect and changes in the speed of vehicle flow during morning and evening peaks in a large- or medium-sized city, the piecewise function is used to capture the rules of the time-varying speed of vehicles, which are very important in modelling their fuel consumption and CO2 emission. A joint optimization model of the green vehicle scheduling and routing problem with time-varying speeds is presented in this study. Extra wages during nonworking periods and soft time-window constraints are considered. A heuristic algorithm based on the adaptive large neighborhood search algorithm is also presented. Finally, a numerical simulation example is provided to illustrate the optimization model and its algorithm. Results show that, (1) the shortest route is not necessarily the route that consumes the least energy, (2) the departure time influences the vehicle fuel consumption and CO2 emissions and the optimal departure time saves on fuel consumption and reduces CO2 emissions by up to 5.4%, and (3) extra driver wages have significant effects on routing and departure time slot decisions. PMID:29466370

  8. Near constant-time optimal piecewise LDR to HDR inverse tone mapping

    Science.gov (United States)

    Chen, Qian; Su, Guan-Ming; Yin, Peng

    2015-02-01

    In a backward compatible HDR image/video compression, it is a general approach to reconstruct HDR from compressed LDR as a prediction to original HDR, which is referred to as inverse tone mapping. Experimental results show that 2- piecewise 2nd order polynomial has the best mapping accuracy than 1 piece high order or 2-piecewise linear, but it is also the most time-consuming method because to find the optimal pivot point to split LDR range to 2 pieces requires exhaustive search. In this paper, we propose a fast algorithm that completes optimal 2-piecewise 2nd order polynomial inverse tone mapping in near constant time without quality degradation. We observe that in least square solution, each entry in the intermediate matrix can be written as the sum of some basic terms, which can be pre-calculated into look-up tables. Since solving the matrix becomes looking up values in tables, computation time barely differs regardless of the number of points searched. Hence, we can carry out the most thorough pivot point search to find the optimal pivot that minimizes MSE in near constant time. Experiment shows that our proposed method achieves the same PSNR performance while saving 60 times computation time compared to the traditional exhaustive search in 2-piecewise 2nd order polynomial inverse tone mapping with continuous constraint.

  9. A Study on the Optimal Duration of Daylight Saving Time (DST in Korea

    Directory of Open Access Journals (Sweden)

    Byeong-Hee Mihn

    2009-09-01

    Full Text Available Daylight saving time aims at spending effective daylight in summer season. Korea had enforced daylight saving time twelve times from 1948 to 1988. Since 1988, it is not executed, but it is recently discussed the resumption of DST. In this paper, we investigate the trend of DST in other countries, review the history of DST in Korea, and suggest the optimal DST duration in terms of astronomical aspects (times of sunrise and sunset. We find that the starting day of DST in Korea is apt for the second Sunday in Mayor the second Sunday in April according to the time of sunrise or to the difference between Korean standard meridian and observer`s, respectively. We also discuss time friction that might be caused by time difference between DST and Korea Standard Time (KST.

  10. Decision theoretical justification of optimization criteria for near-real-time accountancy procedures

    International Nuclear Information System (INIS)

    Avenhaus, R.

    1992-01-01

    In the beginning of nuclear material safeguards, emphasis was placed on safe detection of diversion of nuclear material. Later, the aspect of timely detection became equally important. Since there is a trade-off between these two objectives, the question of an appropriate compromise was raised. In this paper, a decision theoretical framework is presented in which the objectives of the two players, inspector and inspectee, are expressed in terms of general utility functions. Within this framework, optimal safeguards strategies are defined, and furthermore, conditions are formulated under which the optimization criteria corresponding to the objectives mentioned above can be justified

  11. Input price risk and optimal timing of energy investment: choice between fossil- and biofuels

    Energy Technology Data Exchange (ETDEWEB)

    Murto, Pauli; Nese, Gjermund

    2002-05-01

    We consider energy investment, when a choice has to be made between fossil fuel and biomass fired production technologies. A dynamic model is presented to illustrate the effect of the different degrees of input price uncertainty on the choice of technology and the timing of the investment. It is shown that when the choice of technology is irreversible, it may be optimal to postpone the investment even if it would otherwise be optimal to invest in one or both of the plant types. We provide a numerical example based on cost, estimates of two different power plant types. (author)

  12. Input price risk and optimal timing of energy investment: choice between fossil- and biofuels

    International Nuclear Information System (INIS)

    Murto, Pauli; Nese, Gjermund

    2002-01-01

    We consider energy investment, when a choice has to be made between fossil fuel and biomass fired production technologies. A dynamic model is presented to illustrate the effect of the different degrees of input price uncertainty on the choice of technology and the timing of the investment. It is shown that when the choice of technology is irreversible, it may be optimal to postpone the investment even if it would otherwise be optimal to invest in one or both of the plant types. We provide a numerical example based on cost, estimates of two different power plant types. (author)

  13. Contrasting Perspectives of Anesthesiologists and Gastroenterologists on the Optimal Time Interval between Bowel Preparation and Endoscopic Sedation

    Directory of Open Access Journals (Sweden)

    Deepak Agrawal

    2015-01-01

    Full Text Available Background. The optimal time interval between the last ingestion of bowel prep and sedation for colonoscopy remains controversial, despite guidelines that sedation can be administered 2 hours after consumption of clear liquids. Objective. To determine current practice patterns among anesthesiologists and gastroenterologists regarding the optimal time interval for sedation after last ingestion of bowel prep and to understand the rationale underlying their beliefs. Design. Questionnaire survey of anesthesiologists and gastroenterologists in the USA. The questions were focused on the preferred time interval of endoscopy after a polyethylene glycol based preparation in routine cases and select conditions. Results. Responses were received from 109 anesthesiologists and 112 gastroenterologists. 96% of anesthesiologists recommended waiting longer than 2 hours until sedation, in contrast to only 26% of gastroenterologists. The main reason for waiting >2 hours was that PEG was not considered a clear liquid. Most anesthesiologists, but not gastroenterologists, waited longer in patients with history of diabetes or reflux. Conclusions. Anesthesiologists and gastroenterologists do not agree on the optimal interval for sedation after last drink of bowel prep. Most anesthesiologists prefer to wait longer than the recommended 2 hours for clear liquids. The data suggest a need for clearer guidelines on this issue.

  14. Space and time optimization of nuclear reactors by means of the Pontryagin principle

    International Nuclear Information System (INIS)

    Anton, V.

    1979-01-01

    A numerical method is being presented for solving space dependent optimization problems concerning a functional for one dimensional geometries in the few group diffusion approximation. General dimensional analysis was applied to derive relations for the maximum of a functional and the limiting values of the constraints. Two procedures were given for calculating the anisotropic diffusion coefficients in order to improve the results of the diffusion approximation. In this work two procedures were presented for collapsing the microscopic multigroup cross sections, one general and another specific to the space dependent optimization problems solved by means of the Pontryagin maximum principle. Neutron spectrum optimization is performed to ensure the burnup of Pu 239 isotope produced in a thermal nuclear reactor. A procedure is also given for the minimization of finite functional set by means of the Pontryagin maximum principle. A method for determining the characteristics of fission Pseudo products is formulated in one group and multigroup cases. This method is applied in the optimization of the burnup in nuclear reactors with fuel electric cells. A procedure to mjnimze the number of the fuel burnup equations is described. The optimization problems presented and solved in this work point to the efficiency of the maximum principle. Each problem on method presented in the various chapters is accompanied by considerations concerning dual problems and possibilities of further research development. (author)

  15. Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry.

    Science.gov (United States)

    Fryš, Ondřej; Česla, Petr; Bajerová, Petra; Adam, Martin; Ventura, Karel

    2012-09-15

    A method for focused ultrasonic extraction of nitroglycerin, triphenyl amine and acetyl tributyl citrate presented in double-base propellant samples following by the gas chromatography/mass spectrometry analysis was developed. A face-centered central composite design of the experiments and response surface modeling was used for optimization of the time, amplitude and sample amount. The dichloromethane was used as the extractant solvent. The optimal extraction conditions with respect to the maximum yield of the lowest abundant compound triphenyl amine were found at the 20 min extraction time, 35% amplitude of ultrasonic waves and 2.5 g of the propellant sample. The results obtained under optimal conditions were compared with the results achieved with validated Soxhlet extraction method, which is typically used for isolation and pre-concentration of compounds from the samples of explosives. The extraction yields for acetyl tributyl citrate using both extraction methods were comparable; however, the yield of ultrasonic extraction of nitroglycerin and triphenyl amine was lower than using Soxhlet extraction. The possible sources of different extraction yields are estimated and discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. A Regional Time-of-Use Electricity Price Based Optimal Charging Strategy for Electrical Vehicles

    Directory of Open Access Journals (Sweden)

    Jun Yang

    2016-08-01

    Full Text Available With the popularization of electric vehicles (EVs, the out-of-order charging behaviors of large numbers of EVs will bring new challenges to the safe and economic operation of power systems. This paper studies an optimal charging strategy for EVs. For that a typical urban zone is divided into four regions, a regional time-of-use (RTOU electricity price model is proposed to guide EVs when and where to charge considering spatial and temporal characteristics. In light of the elastic coefficient, the user response to the RTOU electricity price is analyzed, and also a bilayer optimization charging strategy including regional-layer and node-layer models is suggested to schedule the EVs. On the one hand, the regional layer model is designed to coordinate the EVs located in different time and space. On the other hand, the node layer model is built to schedule the EVs to charge in certain nodes. According to the simulations of an IEEE 33-bus distribution network, the performance of the proposed optimal charging strategy is verified. The results demonstrate that the proposed bilayer optimization strategy can effectively decrease the charging cost of users, mitigate the peak-valley load difference and the network loss. Besides, the RTOU electricity price shows better performance than the time-of-use (TOU electricity price.

  17. Detecting changes in real-time data: a user's guide to optimal detection.

    Science.gov (United States)

    Johnson, P; Moriarty, J; Peskir, G

    2017-08-13

    The real-time detection of changes in a noisily observed signal is an important problem in applied science and engineering. The study of parametric optimal detection theory began in the 1930s, motivated by applications in production and defence. Today this theory, which aims to minimize a given measure of detection delay under accuracy constraints, finds applications in domains including radar, sonar, seismic activity, global positioning, psychological testing, quality control, communications and power systems engineering. This paper reviews developments in optimal detection theory and sequential analysis, including sequential hypothesis testing and change-point detection, in both Bayesian and classical (non-Bayesian) settings. For clarity of exposition, we work in discrete time and provide a brief discussion of the continuous time setting, including recent developments using stochastic calculus. Different measures of detection delay are presented, together with the corresponding optimal solutions. We emphasize the important role of the signal-to-noise ratio and discuss both the underlying assumptions and some typical applications for each formulation.This article is part of the themed issue 'Energy management: flexibility, risk and optimization'. © 2017 The Author(s).

  18. Dynamic Value Engineering Method Optimizing the Risk on Real Time Operating System

    Directory of Open Access Journals (Sweden)

    Prashant Kumar Patra

    2014-04-01

    Full Text Available The value engineering is the umbrella of the many more sub-system like quality assurance, quality control, quality function design and development for manufacturability. The system engineering & value engineering is two part of the coin. The value engineering is the high level of technology management for every aspect of engineering fields. The value engineering is the high utilization of System Product (i.e. Processor, Memory & Encryption key, Services, Business and Resources at minimal cost. The high end operating system providing highest services at optimal cost & time. The value engineering provides the maximum performance, accountability, reliability, integrity and availability of processor, memory, encryption key and other inter dependency sub-components. The value engineering is the ratio of the maximum functionality of individual components to the optimal cost. VE=k [(P, M, E, C, A]/optimal cost. Where k is the proportionality constant. The VE is directly proportional to performance of individual components and inversely proportional to the minimal cost. The VE is directly proportional to the risk assessment. The VE maximize the business throughput & decision process mean while minimize the risk and down time. We have to develop the dynamic value engineering model & mechanism for risk optimization over a complex real time operating system This proposed composition model definite will be resolve our objective at top high level. Product

  19. Using real options to determine optimal funding strategies for CO2 capture, transport and storage projects in the European Union

    International Nuclear Information System (INIS)

    Eckhause, Jeremy; Herold, Johannes

    2014-01-01

    Several projects in the European Union (EU) are currently under development to implement the carbon capture, transport and storage (CCS) technology on a large scale and may be subject to public funding under EU support initiatives. These CCS projects may develop any combination of three types of operating levels: pilot, demonstration and full-scale, representing progressing levels of electric power generation capability. Several projects have commenced at the demonstration level, with full-scale commercial levels planned for approximately 2020. Taking the perspective of a funding agency, we employ a real options framework for determining an optimal project selection and funding strategy for the development of full-scale CCS plants. Specifically, we formulate and solve a stochastic dynamic program (SDP) for obtaining optimal funding solutions in order to achieve at least one successfully operating full-scale CCS plant by a target year. The model demonstrates the improved risk reduction by employing such a multi-stage competition. We then extend the model to consider two sensitivities: (1) the flexibility to spend that budget among the time periods and (2) optimizing the budget, but specifying each time period's allocation a priori. State size and runtimes of the SDP model are provided. - Highlights: • Projects implementing three different CCS technology types are described. • We obtain projects’ transition probabilities and costs from expert interviews. • We use a multi-stage real options model to obtain optimal funding strategies. • Using this approach, actual decision-makers could reduce risks in CCS development

  20. Product code optimization for determinate state LDPC decoding in robust image transmission.

    Science.gov (United States)

    Thomos, Nikolaos; Boulgouris, Nikolaos V; Strintzis, Michael G

    2006-08-01

    We propose a novel scheme for error-resilient image transmission. The proposed scheme employs a product coder consisting of low-density parity check (LDPC) codes and Reed-Solomon codes in order to deal effectively with bit errors. The efficiency of the proposed scheme is based on the exploitation of determinate symbols in Tanner graph decoding of LDPC codes and a novel product code optimization technique based on error estimation. Experimental evaluation demonstrates the superiority of the proposed system in comparison to recent state-of-the-art techniques for image transmission.

  1. Systematic optimization of exterior measurement locations for the determination of interior magnetic field vector components in inaccessible regions

    Energy Technology Data Exchange (ETDEWEB)

    Nouri, N.; Plaster, B.

    2014-12-11

    An experiment may face the challenge of real-time determination of the magnetic field vector components present within some interior region of the experimental apparatus over which it is impossible to directly measure the field components during the operation of the experiment. As a solution to this problem, we propose a general concept which provides for a unique determination of the field components within such an interior region solely from exterior measurements at fixed discrete locations. The method is general and does not require the field to possess any type of symmetry. We describe our systematic approach for optimizing the locations of these exterior measurements which maximizes their sensitivity to successive terms in a multipole expansion of the field.

  2. Optimal Two-Impulse Trajectories with Moderate Flight Time for Earth-Moon Missions

    Directory of Open Access Journals (Sweden)

    Sandro da Silva Fernandes

    2012-01-01

    describe the motion of the space vehicle: the well-known patched-conic approximation and two versions of the planar circular restricted three-body problem (PCR3BP. In the patched-conic approximation model, the parameters to be optimized are two: initial phase angle of space vehicle and the first velocity impulse. In the PCR3BP models, the parameters to be optimized are four: initial phase angle of space vehicle, flight time, and the first and the second velocity impulses. In all cases, the optimization problem has one degree of freedom and can be solved by means of an algorithm based on gradient method in conjunction with Newton-Raphson method.

  3. On the non-stationarity of financial time series: impact on optimal portfolio selection

    International Nuclear Information System (INIS)

    Livan, Giacomo; Inoue, Jun-ichi; Scalas, Enrico

    2012-01-01

    We investigate the possible drawbacks of employing the standard Pearson estimator to measure correlation coefficients between financial stocks in the presence of non-stationary behavior, and we provide empirical evidence against the well-established common knowledge that using longer price time series provides better, more accurate, correlation estimates. Then, we investigate the possible consequences of instabilities in empirical correlation coefficient measurements on optimal portfolio selection. We rely on previously published works which provide a framework allowing us to take into account possible risk underestimations due to the non-optimality of the portfolio weights being used in order to distinguish such non-optimality effects from risk underestimations genuinely due to non-stationarities. We interpret such results in terms of instabilities in some spectral properties of portfolio correlation matrices. (paper)

  4. Design of an optimal preview controller for linear discrete-time descriptor systems with state delay

    Science.gov (United States)

    Cao, Mengjuan; Liao, Fucheng

    2015-04-01

    In this paper, the linear discrete-time descriptor system with state delay is studied, and a design method for an optimal preview controller is proposed. First, by using the discrete lifting technique, the original system is transformed into a general descriptor system without state delay in form. Then, taking advantage of the first-order forward difference operator, we construct a descriptor augmented error system, including the state vectors of the lifted system, error vectors, and desired target signals. Rigorous mathematical proofs are given for the regularity, stabilisability, causal controllability, and causal observability of the descriptor augmented error system. Based on these, the optimal preview controller with preview feedforward compensation for the original system is obtained by using the standard optimal regulator theory of the descriptor system. The effectiveness of the proposed method is shown by numerical simulation.

  5. Reinforcement learning for adaptive optimal control of unknown continuous-time nonlinear systems with input constraints

    Science.gov (United States)

    Yang, Xiong; Liu, Derong; Wang, Ding

    2014-03-01

    In this paper, an adaptive reinforcement learning-based solution is developed for the infinite-horizon optimal control problem of constrained-input continuous-time nonlinear systems in the presence of nonlinearities with unknown structures. Two different types of neural networks (NNs) are employed to approximate the Hamilton-Jacobi-Bellman equation. That is, an recurrent NN is constructed to identify the unknown dynamical system, and two feedforward NNs are used as the actor and the critic to approximate the optimal control and the optimal cost, respectively. Based on this framework, the action NN and the critic NN are tuned simultaneously, without the requirement for the knowledge of system drift dynamics. Moreover, by using Lyapunov's direct method, the weights of the action NN and the critic NN are guaranteed to be uniformly ultimately bounded, while keeping the closed-loop system stable. To demonstrate the effectiveness of the present approach, simulation results are illustrated.

  6. Optimization time synthesis of nucleotide labelled [γ-32P]-ATP

    International Nuclear Information System (INIS)

    Rahman, Wira Y; Sarmini, Endang; Herlina; Lubis, Hotman; Triyanto; Hambali

    2013-01-01

    Adenosine triphosphate-labelled with γ- 32 P([γ- 32 p]-ATP) has been widely used in the biotechnology research, usually as a tracer to study aspects of physiological and pathological processes. In order to support biotechnology research in Indonesia, a process for production of [γ- 32 P]-ATP with enzymatic reaction was used as precursors DL-glyceraldehydde 3-phosphate, Adenosine Diphosphate (ADP) and H 3 32 PO 4 , and enzyme glyceraldehid 3-phosphate dehydrogenase, 3-phosphoglyceryc phosphokinase and lactate dehydrogenase. Optimization of incubation time labeled nucleotide synthesis process is performed to find the optimum conditions, in terms of the most advantageous time in the synthesis process. With the success of the synthesis and optimization is done incubation time of synthesis labeled nucleotide, the result suggested can be used for producing [γ- 32 P] -ATP to support the provision of radiolabeled nucleotide for biotechnology research in Indonesia. (author)

  7. Optimal time-domain combination of the two calibrated output quadratures of GEO 600

    International Nuclear Information System (INIS)

    Hewitson, M; Grote, H; Hild, S; Lueck, H; Ajith, P; Smith, J R; Strain, K A; Willke, B; Woan, G

    2005-01-01

    GEO 600 is an interferometric gravitational wave detector with a 600 m arm-length and which uses a dual-recycled optical configuration to give enhanced sensitivity over certain frequencies in the detection band. Due to the dual-recycling, GEO 600 has two main output signals, both of which potentially contain gravitational wave signals. These two outputs are calibrated to strain using a time-domain method. In order to simplify the analysis of the GEO 600 data set, it is desirable to combine these two calibrated outputs to form a single strain signal that has optimal signal-to-noise ratio across the detection band. This paper describes a time-domain method for doing this combination. The method presented is similar to one developed for optimally combining the outputs of two colocated gravitational wave detectors. In the scheme presented in this paper, some simplifications are made to allow its implementation using time-domain methods

  8. A strategy for reducing turnaround time in design optimization using a distributed computer system

    Science.gov (United States)

    Young, Katherine C.; Padula, Sharon L.; Rogers, James L.

    1988-01-01

    There is a need to explore methods for reducing lengthly computer turnaround or clock time associated with engineering design problems. Different strategies can be employed to reduce this turnaround time. One strategy is to run validated analysis software on a network of existing smaller computers so that portions of the computation can be done in parallel. This paper focuses on the implementation of this method using two types of problems. The first type is a traditional structural design optimization problem, which is characterized by a simple data flow and a complicated analysis. The second type of problem uses an existing computer program designed to study multilevel optimization techniques. This problem is characterized by complicated data flow and a simple analysis. The paper shows that distributed computing can be a viable means for reducing computational turnaround time for engineering design problems that lend themselves to decomposition. Parallel computing can be accomplished with a minimal cost in terms of hardware and software.

  9. Optimal bounds and extremal trajectories for time averages in nonlinear dynamical systems

    Science.gov (United States)

    Tobasco, Ian; Goluskin, David; Doering, Charles R.

    2018-02-01

    For any quantity of interest in a system governed by ordinary differential equations, it is natural to seek the largest (or smallest) long-time average among solution trajectories, as well as the extremal trajectories themselves. Upper bounds on time averages can be proved a priori using auxiliary functions, the optimal choice of which is a convex optimization problem. We prove that the problems of finding maximal trajectories and minimal auxiliary functions are strongly dual. Thus, auxiliary functions provide arbitrarily sharp upper bounds on time averages. Moreover, any nearly minimal auxiliary function provides phase space volumes in which all nearly maximal trajectories are guaranteed to lie. For polynomial equations, auxiliary functions can be constructed by semidefinite programming, which we illustrate using the Lorenz system.

  10. Discrete-Time Stable Generalized Self-Learning Optimal Control With Approximation Errors.

    Science.gov (United States)

    Wei, Qinglai; Li, Benkai; Song, Ruizhuo

    2018-04-01

    In this paper, a generalized policy iteration (GPI) algorithm with approximation errors is developed for solving infinite horizon optimal control problems for nonlinear systems. The developed stable GPI algorithm provides a general structure of discrete-time iterative adaptive dynamic programming algorithms, by which most of the discrete-time reinforcement learning algorithms can be described using the GPI structure. It is for the first time that approximation errors are explicitly considered in the GPI algorithm. The properties of the stable GPI algorithm with approximation errors are analyzed. The admissibility of the approximate iterative control law can be guaranteed if the approximation errors satisfy the admissibility criteria. The convergence of the developed algorithm is established, which shows that the iterative value function is convergent to a finite neighborhood of the optimal performance index function, if the approximate errors satisfy the convergence criterion. Finally, numerical examples and comparisons are presented.

  11. Optimization of the Determination Method for Dissolved Cyanobacterial Toxin BMAA in Natural Water.

    Science.gov (United States)

    Yan, Boyin; Liu, Zhiquan; Huang, Rui; Xu, Yongpeng; Liu, Dongmei; Lin, Tsair-Fuh; Cui, Fuyi

    2017-10-17

    There is a serious dispute on the existence of β-N-methylamino-l-alanine (BMAA) in water, which is a neurotoxin that may cause amyotrophic lateral sclerosis/Parkinson's disease (ALS/PDC) and Alzheimer' disease. It is believed that a reliable and sensitive analytical method for the determination of BMAA is urgently required to resolve this dispute. In the present study, the solid phase extraction (SPE) procedure and the analytical method for dissolved BMAA in water were investigated and optimized. The results showed both derivatized and underivatized methods were qualified for the measurement of BMAA and its isomer in natural water, and the limit of detection and the precision of the two methods were comparable. Cartridge characteristics and SPE conditions could greatly affect the SPE performance, and the competition of natural organic matter is the primary factor causing the low recovery of BMAA, which was reduced from approximately 90% in pure water to 38.11% in natural water. The optimized SPE method for BMAA was a combination of rinsed SPE cartridges, controlled loading/elution rates and elution solution, evaporation at 55 °C, reconstitution of a solution mixture, and filtration by polyvinylidene fluoride membrane. This optimized method achieved > 88% recovery of BMAA in both algal solution and river water. The developed method can provide an efficient way to evaluate the actual concentration levels of BMAA in actual water environments and drinking water systems.

  12. Optimization method to determine mass transfer variables in a PWR crud deposition risk assessment tool

    International Nuclear Information System (INIS)

    Do, Chuong; Hussey, Dennis; Wells, Daniel M.; Epperson, Kenny

    2016-01-01

    Optimization numerical method was implemented to determine several mass transfer coefficients in a crud-induced power shift risk assessment code. The approach was to utilize a multilevel strategy that targets different model parameters that first changes the major order variables, mass transfer inputs, then calibrates the minor order variables, crud source terms, according to available plant data. In this manner, the mass transfer inputs are effectively simplified as 'dependent' on the crud source terms. Two optimization studies were performed using DAKOTA, a design and analysis toolkit, with the difference between the runs, being the number of model runs using BOA, allowed for adjusting the crud source terms, therefore, reducing the uncertainty with calibration. The result of the first case showed that the current best estimated values for the mass transfer coefficients, which were derived from first principle analysis, can be considered an optimized set. When the run limit of BOA was increased for the second case, an improvement in the prediction was obtained with the results deviating slightly from the best estimated values. (author)

  13. Optimization of the n-type HPGe detector parameters to theoretical determination of efficiency curves

    International Nuclear Information System (INIS)

    Rodriguez-Rodriguez, A.; Correa-Alfonso, C.M.; Lopez-Pino, N.; Padilla-Cabal, F.; D'Alessandro, K.; Corrales, Y.; Garcia-Alvarez, J. A.; Perez-Mellor, A.; Baly-Gil, L.; Machado, A.

    2011-01-01

    A highly detailed characterization of a 130 cm 3 n-type HPGe detector, employed in low - background gamma spectrometry measurements, was done. Precise measured data and several Monte Carlo (MC) calculations have been combined to optimize the detector parameters. HPGe crystal location inside the Aluminum end-cap as well as its dimensions, including the borehole radius and height, were determined from frontal and lateral scans. Additionally, X-ray radiography and Computed Axial Tomography (CT) studies were carried out to complement the information about detector features. Using seven calibrated point sources ( 241 Am, 133 Ba, 57,60 Co, 137 Cs, 22 Na and 152 Eu), photo-peak efficiency curves at three different source - detector distances (SDD) were obtained. Taking into account the experimental values, an optimization procedure by means of MC simulations (MCNPX 2.6 code) were performed. MC efficiency curves were calculated specifying the optimized detector parameters in the MCNPX input files. Efficiency calculation results agree with empirical data, showing relative deviations lesser 10%. (Author)

  14. A 75 ps rms time resolution BiCMOS time to digital converter optimized for high rate imaging detectors

    CERN Document Server

    Hervé, C

    2002-01-01

    This paper presents an integrated time to digital converter (TDC) with a bin size adjustable in the range of 125 to 175 ps and a differential nonlinearity of +-0.3%. The TDC has four channels. Its architecture has been optimized for the readout of imaging detectors in use at Synchrotron Radiation facilities. In particular, a built-in logic flags piled-up events. Multi-hit patterns are also supported for other applications. Time measurements are extracted off chip at the maximum throughput of 40 MHz. The dynamic range is 14 bits. It has been fabricated in 0.8 mu m BiCMOS technology. Time critical inputs are PECL compatible whereas other signals are CMOS compatible. A second application specific integrated circuit (ASIC) has been developed which translates NIM electrical levels to PECL ones. Both circuits are used to assemble board level TDCs complying with industry standards like VME, NIM and PCI.

  15. Dynamic Planar Convex Hull with Optimal Query Time and O(log n · log log n ) Update Time

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Jakob, Riko

    2000-01-01

    The dynamic maintenance of the convex hull of a set of points in the plane is one of the most important problems in computational geometry. We present a data structure supporting point insertions in amortized O(log n · log log log n) time, point deletions in amortized O(log n · log log n) time......, and various queries about the convex hull in optimal O(log n) worst-case time. The data structure requires O(n) space. Applications of the new dynamic convex hull data structure are improved deterministic algorithms for the k-level problem and the red-blue segment intersection problem where all red and all...

  16. Optimal replenishment and credit policy in supply chain inventory model under two levels of trade credit with time- and credit-sensitive demand involving default risk

    Science.gov (United States)

    Mahata, Puspita; Mahata, Gour Chandra; Kumar De, Sujit

    2018-03-01

    Traditional supply chain inventory modes with trade credit usually only assumed that the up-stream suppliers offered the down-stream retailers a fixed credit period. However, in practice the retailers will also provide a credit period to customers to promote the market competition. In this paper, we formulate an optimal supply chain inventory model under two levels of trade credit policy with default risk consideration. Here, the demand is assumed to be credit-sensitive and increasing function of time. The major objective is to determine the retailer's optimal credit period and cycle time such that the total profit per unit time is maximized. The existence and uniqueness of the optimal solution to the presented model are examined, and an easy method is also shown to find the optimal inventory policies of the considered problem. Finally, numerical examples and sensitive analysis are presented to illustrate the developed model and to provide some managerial insights.

  17. Real-time motion-adaptive-optimization (MAO) in TomoTherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lu Weiguo; Chen Mingli; Ruchala, Kenneth J; Chen Quan; Olivera, Gustavo H [TomoTherapy Inc., 1240 Deming Way, Madison, WI (United States); Langen, Katja M; Kupelian, Patrick A [MD Anderson Cancer Center-Orlando, Orlando, FL (United States)], E-mail: wlu@tomotherapy.com

    2009-07-21

    IMRT delivery follows a planned leaf sequence, which is optimized before treatment delivery. However, it is hard to model real-time variations, such as respiration, in the planning procedure. In this paper, we propose a negative feedback system of IMRT delivery that incorporates real-time optimization to account for intra-fraction motion. Specifically, we developed a feasible workflow of real-time motion-adaptive-optimization (MAO) for TomoTherapy delivery. TomoTherapy delivery is characterized by thousands of projections with a fast projection rate and ultra-fast binary leaf motion. The technique of MAO-guided delivery calculates (i) the motion-encoded dose that has been delivered up to any given projection during the delivery and (ii) the future dose that will be delivered based on the estimated motion probability and future fluence map. These two pieces of information are then used to optimize the leaf open time of the upcoming projection right before its delivery. It consists of several real-time procedures, including 'motion detection and prediction', 'delivered dose accumulation', 'future dose estimation' and 'projection optimization'. Real-time MAO requires that all procedures are executed in time less than the duration of a projection. We implemented and tested this technique using a TomoTherapy (registered) research system. The MAO calculation took about 100 ms per projection. We calculated and compared MAO-guided delivery with two other types of delivery, motion-without-compensation delivery (MD) and static delivery (SD), using simulated 1D cases, real TomoTherapy plans and the motion traces from clinical lung and prostate patients. The results showed that the proposed technique effectively compensated for motion errors of all test cases. Dose distributions and DVHs of MAO-guided delivery approached those of SD, for regular and irregular respiration with a peak-to-peak amplitude of 3 cm, and for medium and large

  18. Real-time motion-adaptive-optimization (MAO) in TomoTherapy

    International Nuclear Information System (INIS)

    Lu Weiguo; Chen Mingli; Ruchala, Kenneth J; Chen Quan; Olivera, Gustavo H; Langen, Katja M; Kupelian, Patrick A

    2009-01-01

    IMRT delivery follows a planned leaf sequence, which is optimized before treatment delivery. However, it is hard to model real-time variations, such as respiration, in the planning procedure. In this paper, we propose a negative feedback system of IMRT delivery that incorporates real-time optimization to account for intra-fraction motion. Specifically, we developed a feasible workflow of real-time motion-adaptive-optimization (MAO) for TomoTherapy delivery. TomoTherapy delivery is characterized by thousands of projections with a fast projection rate and ultra-fast binary leaf motion. The technique of MAO-guided delivery calculates (i) the motion-encoded dose that has been delivered up to any given projection during the delivery and (ii) the future dose that will be delivered based on the estimated motion probability and future fluence map. These two pieces of information are then used to optimize the leaf open time of the upcoming projection right before its delivery. It consists of several real-time procedures, including 'motion detection and prediction', 'delivered dose accumulation', 'future dose estimation' and 'projection optimization'. Real-time MAO requires that all procedures are executed in time less than the duration of a projection. We implemented and tested this technique using a TomoTherapy (registered) research system. The MAO calculation took about 100 ms per projection. We calculated and compared MAO-guided delivery with two other types of delivery, motion-without-compensation delivery (MD) and static delivery (SD), using simulated 1D cases, real TomoTherapy plans and the motion traces from clinical lung and prostate patients. The results showed that the proposed technique effectively compensated for motion errors of all test cases. Dose distributions and DVHs of MAO-guided delivery approached those of SD, for regular and irregular respiration with a peak-to-peak amplitude of 3 cm, and for medium and large prostate motions. The results conceptually

  19. Residence time determination for adsorbent beds of different configurations

    Energy Technology Data Exchange (ETDEWEB)

    Otermat, J.E.; Wikoff, W.O.; Kovach, J.L.

    1995-02-01

    The residence time calculations of ASME AG-1 Code, Section FC, currently specify a screen surface area method, that is technically incorrect. Test data has been obtained on Type II adsorber trays of different configurations to establish residence time in the adsorber trays. These data indicate that the air volume/carbon volume ratio or the average screen area are more appropriate for the calculation of the residence time calculation than the currently used, smallest screen area basis.

  20. Determination of the optimal tolerance for MLC positioning in sliding window and VMAT techniques

    International Nuclear Information System (INIS)

    Hernandez, V.; Abella, R.; Calvo, J. F.; Jurado-Bruggemann, D.; Sancho, I.; Carrasco, P.

    2015-01-01

    Purpose: Several authors have recommended a 2 mm tolerance for multileaf collimator (MLC) positioning in sliding window treatments. In volumetric modulated arc therapy (VMAT) treatments, however, the optimal tolerance for MLC positioning remains unknown. In this paper, the authors present the results of a multicenter study to determine the optimal tolerance for both techniques. Methods: The procedure used is based on dynalog file analysis. The study was carried out using seven Varian linear accelerators from five different centers. Dynalogs were collected from over 100 000 clinical treatments and in-house software was used to compute the number of tolerance faults as a function of the user-defined tolerance. Thus, the optimal value for this tolerance, defined as the lowest achievable value, was investigated. Results: Dynalog files accurately predict the number of tolerance faults as a function of the tolerance value, especially for low fault incidences. All MLCs behaved similarly and the Millennium120 and the HD120 models yielded comparable results. In sliding window techniques, the number of beams with an incidence of hold-offs >1% rapidly decreases for a tolerance of 1.5 mm. In VMAT techniques, the number of tolerance faults sharply drops for tolerances around 2 mm. For a tolerance of 2.5 mm, less than 0.1% of the VMAT arcs presented tolerance faults. Conclusions: Dynalog analysis provides a feasible method for investigating the optimal tolerance for MLC positioning in dynamic fields. In sliding window treatments, the tolerance of 2 mm was found to be adequate, although it can be reduced to 1.5 mm. In VMAT treatments, the typically used 5 mm tolerance is excessively high. Instead, a tolerance of 2.5 mm is recommended