WorldWideScience

Sample records for design utilizing empirical

  1. Empirical Research In Engineering Design

    DEFF Research Database (Denmark)

    Ahmed, Saeema

    2007-01-01

    Increasingly engineering design research involves the use of empirical studies that are conducted within an industrial environment [Ahmed, 2001; Court 1995; Hales 1987]. Research into the use of information by designers or understanding how engineers build up experience are examples of research...... of research issues. This paper describes case studies of empirical research carried out within industry in engineering design focusing upon information, knowledge and experience in engineering design. The paper describes the research methods employed, their suitability for the particular research aims...

  2. Conceptual and Empirical Themes regarding the Design of Technology Transfer Programs: A Review of Wood Utilization Research in the United States

    Directory of Open Access Journals (Sweden)

    Paul V. Ellefson

    2011-01-01

    Full Text Available Transfer of technologies produced by research is critical to innovation within all organizations. The intent of this paper is to take stock of the conceptual underpinnings of technology transfer processes as they relate to wood utilization research and to identify conditions that promote the successful transfer of research results. Conceptually, research utilization can be viewed from multiple perspectives, including the haphazard diffusion of knowledge in response to vague and imprecise demands for information, scanning of multiple information sources by individuals and organizations searching for useful scientific knowledge, engagement of third parties to organize research results and communicate them to potential users, and ongoing and active collaboration between researchers and potential users of research. Empirical evidence suggests that various types of programs can promote technology transfer (venture capital, angel investors, business incubators, extension services, tax incentives, and in-house entities, the fundamental effectiveness of which depends on research results that are scientifically valid and consistent with the information needs of potential users. Furthermore, evidence suggests preference toward programs that are appropriately organized and governed, suitably led and creatively administered, and periodically evaluated in accordance with clear standards of success.

  3. Conceptual and empirical themes regarding the design of technology transfer programs : a review of wood utilization research in the United States

    Science.gov (United States)

    Paul V. Ellefson; Michael A. Kilgore; Kenneth E. Skog; Christopher D. Risbrudt

    2011-01-01

    Transfer of technologies produced by research is critical to innovation within all organizations. The intent of this paper is to take stock of the conceptual underpinnings of technology transfer processes as they relate to wood utilization research and to identify conditions that promote the successful transfer of research results. Conceptually, research utilization...

  4. Empirical direction in design and analysis

    CERN Document Server

    Anderson, Norman H

    2001-01-01

    The goal of Norman H. Anderson's new book is to help students develop skills of scientific inference. To accomplish this he organized the book around the ""Experimental Pyramid""--six levels that represent a hierarchy of considerations in empirical investigation--conceptual framework, phenomena, behavior, measurement, design, and statistical inference. To facilitate conceptual and empirical understanding, Anderson de-emphasizes computational formulas and null hypothesis testing. Other features include: *emphasis on visual inspection as a basic skill in experimental analysis to help student

  5. Precision and accuracy of mechanistic-empirical pavement design

    CSIR Research Space (South Africa)

    Theyse, HL

    2006-09-01

    Full Text Available The availability of mechanistic-empirical pavement design methods is increasing internationally. Although mechanistic-empirical design does offer some insight into pavement behaviour and performance, at least more so than empirical design methods...

  6. Visual Design Principles: An Empirical Study of Design Lore

    Science.gov (United States)

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  7. Utility impact on STARFIRE design

    International Nuclear Information System (INIS)

    DeFreece, D.A.; Waganer, L.M.; Woklenhauer, W.C.

    1981-01-01

    A primary objective of STARFIRE has been to design a tokamak fusion power plant that was attractive to the utilities. To achieve this goal, several utility representatives were directly involved in the decision-making processes as the design evolved. An initial step was to establish the relative importance to the utilities for an extensive list of economic, performance, safety and environmental issues. The top twenty issues were ranked. Cost of electricity was clearly most important with very little spread in the ratings of individual evaluators. Licensing is a go/no-go factor and must be accomplished for the other factors to have meaning. The top nine factors were judged to be very important by all evaluators, as was shown by the spread of ratings from 5 to 10. There is considerably more spread in the bottom eleven, which reflects a lack of consensus as to the relative importance of the evaluation factors. This evaluation was utilized in establishing the initial design concept

  8. AASHTO mechanistic-empirical pavement design guide parametric study.

    Science.gov (United States)

    2012-03-01

    This study focuses on assessing the robustness of the AASHTO Mechanistic-Empirical Pavement Design Guide (MEPDG v 1.1) for rigid pavement : design projects in Wisconsin. The primary tasks conducted in this study included performing sensitivity analys...

  9. Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design.

    Science.gov (United States)

    Schlesinger, Erica; Ciaccio, Natalie; Desai, Tejal A

    2015-12-01

    To define empirical models and parameters based on theoretical equations to describe drug release profiles from two polycaprolactone thin-film drug delivery systems. Additionally, to develop a predictive model for empirical parameters based on drugs' physicochemical properties. Release profiles from a selection of drugs representing the standard pharmaceutical space in both polycaprolactone matrix and reservoir systems were determined experimentally. The proposed models were used to calculate empirical parameters describing drug diffusion and release. Observed correlations between empirical parameters and drug properties were used to develop equations to predict parameters based on drug properties. Predictive and empirical models were evaluated in the design of three prototype devices: a levonorgestrel matrix system for on-demand locally administered contraception, a timolol-maleate reservoir system for glaucoma treatment, and a primaquine-bisphosphate reservoir system for malaria prophylaxis. Proposed empirical equations accurately fit experimental data. Experimentally derived empirical parameters show significant correlations with LogP, molecular weight, and solubility. Empirical models based on predicted parameters accurately predict experimental release data for three prototype systems, demonstrating the accuracy and utility of these models. The proposed empirical models can be used to design polycaprolactone thin-film devices for target geometries and release rates. Empirical parameters can be predicted based on drug properties. Together, these models provide tools for preliminary evaluation and design of controlled-release delivery systems. Copyright © 2015. Published by Elsevier B.V.

  10. Empirical pillar design methods review report: Final report

    International Nuclear Information System (INIS)

    1988-02-01

    This report summarizes and evaluates empirical pillar design methods that may be of use during the conceptual design of a high-level nuclear waste repository in salt. The methods are discussed according to category (i.e, main, submain, and panel pillars; barrier pillars; and shaft pillars). Of the 21 identified for main, submain, and panel pillars, one method, the Confined Core Method, is evaluated as being most appropriate for conceptual design. Five methods are considered potentially applicable. Of six methods identified for barrier pillars, one method based on the Load Transfer Distance concept is considered most appropriate for design. Based on the evaluation of 25 methods identified for shaft pillars, an approximate sizing criterion is proposed for use in conceptual design. Aspects of pillar performance relating to creep, ground deformation, interaction with roof and floor rock, and response to high temperature environments are not adequately addressed by existing empirical design methods. 152 refs., 22 figs., 14 tabs

  11. Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

    DEFF Research Database (Denmark)

    Özkil, Ali Gürcan

    2017-01-01

    This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489...... designs and 247 768 users; and it reveals that (i) Designs can be shared and quickly evolved into other designs through a distributed network of designers, (ii) only a small portion of the users are designers and (iv) collective design has deep and strong evolutionary roots. Better understanding...... of collective design platforms can help design practitioners to identify lead users in their respective domains and to discover latent needs that stem from different sub-communities or geographic regions....

  12. The regulatory treatment of adverse outcomes: Empirical evidence from the electric utility industry

    International Nuclear Information System (INIS)

    Ryan, N.E.

    1991-01-01

    This dissertation consists of two essays, both of them empirical studies using data from the US electric utility industry. Part I focuses on utilities' investment behavior, while Part II examines regulatory policy toward the industry. The first paper presents an analysis of utilities' decisions about whether to continue or cancel nuclear construction projects. During the seventies and eighties, changes in economic conditions and regulatory policy radically altered the costs and benefits of nuclear power. This study seeks to determine whether regulators pursued policies which induced utilities to employ socially efficient criteria in re-evaluating ongoing projects. The analysis also yields insights into regulators' distributional goals. Results based on data for 1978-84 are consistent with the capture theory hypothesis, which holds that regulators weigh industry interests more heavily than consumer interests. A test for structural change provides no support for the contention that the relative importance of consumer interests increased over this period. These empirical findings are inconsistent with a standard (and essential) assumption of theoretical principal-agent models of rate-of-return regulation, that regulators value consumers' payoffs more than utility profits. The second paper examines regulatory policy toward generating facilities that entered commercial service during the years 1983-88. In a significant departure from past practice, state public utility commissions often denied utilities full recovery of their investments in new plants. Although such ex post disallowances have an important efficiency rationale, they also provide a means for opportunistic regulators to effect transfers between utilities' ratepayers and shareholders. A probit model was used to assess the impact on the probability of a disallowance of firm and project characteristics as well as attributes of a state's political and institutional environment

  13. Why do electricity utilities cooperate with coal suppliers? A theoretical and empirical analysis from China

    International Nuclear Information System (INIS)

    Zhao Xiaoli; Lyon, Thomas P.; Wang Feng; Song Cui

    2012-01-01

    The asymmetry of Chinese coal and electricity pricing reforms leads to serious conflict between coal suppliers and electricity utilities. Electricity utilities experience significant losses as a result of conflict: severe coal price fluctuations, and uncertainty in the quantity and quality of coal supplies. This paper explores whether establishing cooperative relationships between coal suppliers and electricity utilities can resolve conflicts. We begin with a discussion of the history of coal and electricity pricing reforms, and then conduct a theoretical analysis of relational contracting to provide a new perspective on the drivers behind the establishment of cooperative relationships between the two parties. Finally, we empirically investigate the role of cooperative relationships and the establishment of mine-mouth power plants on the performance of electricity utilities. The results show that relational contracting between electricity utilities and coal suppliers improves the market performance of electricity utilities; meanwhile, the transportation cost savings derived from mine-mouth power plants are of importance in improving the performance of electricity utilities. - Highlights: ► We discuss the history of coal and electricity pricing reforms. ► The roots of conflicts between electricity and coal firms are presented. ► We conduct a theoretical analysis of relational contracting. ► The role of mine-mouth power plants on the performance of power firms is examined.

  14. Computational RNA secondary structure design: empirical complexity and improved methods

    Directory of Open Access Journals (Sweden)

    Condon Anne

    2007-01-01

    Full Text Available Abstract Background We investigate the empirical complexity of the RNA secondary structure design problem, that is, the scaling of the typical difficulty of the design task for various classes of RNA structures as the size of the target structure is increased. The purpose of this work is to understand better the factors that make RNA structures hard to design for existing, high-performance algorithms. Such understanding provides the basis for improving the performance of one of the best algorithms for this problem, RNA-SSD, and for characterising its limitations. Results To gain insights into the practical complexity of the problem, we present a scaling analysis on random and biologically motivated structures using an improved version of the RNA-SSD algorithm, and also the RNAinverse algorithm from the Vienna package. Since primary structure constraints are relevant for designing RNA structures, we also investigate the correlation between the number and the location of the primary structure constraints when designing structures and the performance of the RNA-SSD algorithm. The scaling analysis on random and biologically motivated structures supports the hypothesis that the running time of both algorithms scales polynomially with the size of the structure. We also found that the algorithms are in general faster when constraints are placed only on paired bases in the structure. Furthermore, we prove that, according to the standard thermodynamic model, for some structures that the RNA-SSD algorithm was unable to design, there exists no sequence whose minimum free energy structure is the target structure. Conclusion Our analysis helps to better understand the strengths and limitations of both the RNA-SSD and RNAinverse algorithms, and suggests ways in which the performance of these algorithms can be further improved.

  15. Relative importance and utility of positive worker states: a review and empirical examination.

    Science.gov (United States)

    Steele, John P; Rupayana, Disha D; Mills, Maura J; Smith, Michael R; Wefald, Andrew; Downey, Ronald G

    2012-01-01

    Our purpose was to identity the unique contribution, relative importance, and utility of positive worker states. Using Luthans et al.'s (2007) five positive organizational behavior criteria, a variety of positive worker states were reviewed and then empirically tested to establish if they met these criteria. Data were collected from 724 restaurant employees. Positive worker states included: job involvement, perceived organizational support, engagement, and vigor. Criteria were self-reported performance, customer service, turnover intention, satisfaction, and quality of life. Our review indicated consistency between predictor adequacy of meeting the criteria and their empirical relationship with key outcomes. This research found the positive worker states to be independent constructs that had differential effects depending on the focused outcome. Regression and relative weights analyses showed involvement was a weak predictor of outcomes, while perceived organizational support was the most consistent predictor. Vigor was most useful when predicting job performance. Quality of life was poorly explained.

  16. Design, engineering and utility of biotic games.

    Science.gov (United States)

    Riedel-Kruse, Ingmar H; Chung, Alice M; Dura, Burak; Hamilton, Andrea L; Lee, Byung C

    2011-01-07

    Games are a significant and defining part of human culture, and their utility beyond pure entertainment has been demonstrated with so-called 'serious games'. Biotechnology--despite its recent advancements--has had no impact on gaming yet. Here we propose the concept of 'biotic games', i.e., games that operate on biological processes. Utilizing a variety of biological processes we designed and tested a collection of games: 'Enlightenment', 'Ciliaball', 'PAC-mecium', 'Microbash', 'Biotic Pinball', 'POND PONG', 'PolymerRace', and 'The Prisoner's Smellemma'. We found that biotic games exhibit unique features compared to existing game modalities, such as utilizing biological noise, providing a real-life experience rather than virtual reality, and integrating the chemical senses into play. Analogous to video games, biotic games could have significant conceptual and cost-reducing effects on biotechnology and eventually healthcare; enable volunteers to participate in crowd-sourcing to support medical research; and educate society at large to support personal medical decisions and the public discourse on bio-related issues.

  17. Empirical fitness models for hepatitis C virus immunogen design.

    Science.gov (United States)

    Hart, Gregory R; Ferguson, Andrew L

    2015-11-24

    Hepatitis C virus (HCV) afflicts 170 million people worldwide, 2%-3% of the global population, and kills 350 000 each year. Prophylactic vaccination offers the most realistic and cost effective hope of controlling this epidemic in the developing world where expensive drug therapies are not available. Despite 20 years of research, the high mutability of the virus and lack of knowledge of what constitutes effective immune responses have impeded development of an effective vaccine. Coupling data mining of sequence databases with spin glass models from statistical physics, we have developed a computational approach to translate clinical sequence databases into empirical fitness landscapes quantifying the replicative capacity of the virus as a function of its amino acid sequence. These landscapes explicitly connect viral genotype to phenotypic fitness, and reveal vulnerable immunological targets within the viral proteome that can be exploited to rationally design vaccine immunogens. We have recovered the empirical fitness landscape for the HCV RNA-dependent RNA polymerase (protein NS5B) responsible for viral genome replication, and validated the predictions of our model by demonstrating excellent accord with experimental measurements and clinical observations. We have used our landscapes to perform exhaustive in silico screening of 16.8 million T-cell immunogen candidates to identify 86 optimal formulations. By reducing the search space of immunogen candidates by over five orders of magnitude, our approach can offer valuable savings in time, expense, and labor for experimental vaccine development and accelerate the search for a HCV vaccine. HCV-hepatitis C virus, HLA-human leukocyte antigen, CTL-cytotoxic T lymphocyte, NS5B-nonstructural protein 5B, MSA-multiple sequence alignment, PEG-IFN-pegylated interferon.

  18. Empirical fitness models for hepatitis C virus immunogen design

    Science.gov (United States)

    Hart, Gregory R.; Ferguson, Andrew L.

    2015-12-01

    Hepatitis C virus (HCV) afflicts 170 million people worldwide, 2%-3% of the global population, and kills 350 000 each year. Prophylactic vaccination offers the most realistic and cost effective hope of controlling this epidemic in the developing world where expensive drug therapies are not available. Despite 20 years of research, the high mutability of the virus and lack of knowledge of what constitutes effective immune responses have impeded development of an effective vaccine. Coupling data mining of sequence databases with spin glass models from statistical physics, we have developed a computational approach to translate clinical sequence databases into empirical fitness landscapes quantifying the replicative capacity of the virus as a function of its amino acid sequence. These landscapes explicitly connect viral genotype to phenotypic fitness, and reveal vulnerable immunological targets within the viral proteome that can be exploited to rationally design vaccine immunogens. We have recovered the empirical fitness landscape for the HCV RNA-dependent RNA polymerase (protein NS5B) responsible for viral genome replication, and validated the predictions of our model by demonstrating excellent accord with experimental measurements and clinical observations. We have used our landscapes to perform exhaustive in silico screening of 16.8 million T-cell immunogen candidates to identify 86 optimal formulations. By reducing the search space of immunogen candidates by over five orders of magnitude, our approach can offer valuable savings in time, expense, and labor for experimental vaccine development and accelerate the search for a HCV vaccine. Abbreviations: HCV—hepatitis C virus, HLA—human leukocyte antigen, CTL—cytotoxic T lymphocyte, NS5B—nonstructural protein 5B, MSA—multiple sequence alignment, PEG-IFN—pegylated interferon.

  19. Kinetic and empirical design criteria for constructed wetlands

    International Nuclear Information System (INIS)

    Nix, P.G.; Gulley, J.R.

    1995-01-01

    A study was conducted to demonstrate the capabilities of wetlands as long-term, self-sustaining natural systems for the treatment of large quantities of waste water released from tailings ponds after mine abandonment. Constructed wetlands were built and planted with aquatic plants. The experimental design included three replicate trenches for each of two treatment systems. The objective of the research was to assess the optimum contaminant loading rates which would result in an acceptable quality of the effluent water. Using empirical data (i.e., hydrocarbon loading rates versus effluent quality), the optimal range of hydrocarbon loading was 5 to 25 gTEH/m 2/ month. Using more conservative kinetic data (i.e. microbial mineralization rates), the range of optimal treatment effectiveness was 9.6 to 13.2 gTEH/m 2/ month. The two design criteria methodologies were calculated using two independent analytical methods. The similarity in results was judged to be a confirmation of their accuracy. 20 refs., 5 figs

  20. Information visualization and proxemics: design opportunities and empirical findings.

    Science.gov (United States)

    Jakobsen, Mikkel R; Sahlemariam Haile, Yonas; Knudsen, Søren; Hornbæk, Kasper

    2013-12-01

    People typically interact with information visualizations using a mouse. Their physical movement, orientation, and distance to visualizations are rarely used as input. We explore how to use such spatial relations among people and visualizations (i.e., proxemics) to drive interaction with visualizations, focusing here on the spatial relations between a single user and visualizations on a large display. We implement interaction techniques that zoom and pan, query and relate, and adapt visualizations based on tracking of users' position in relation to a large high-resolution display. Alternative prototypes are tested in three user studies and compared with baseline conditions that use a mouse. Our aim is to gain empirical data on the usefulness of a range of design possibilities and to generate more ideas. Among other things, the results show promise for changing zoom level or visual representation with the user's physical distance to a large display. We discuss possible benefits and potential issues to avoid when designing information visualizations that use proxemics.

  1. Mechanistic-empirical design concepts for continuously reinforced concrete pavements in Illinois.

    Science.gov (United States)

    2009-04-01

    The Illinois Department of Transportation (IDOT) currently has an existing jointed plain concrete pavement : (JPCP) design based on mechanistic-empirical (M-E) principles. However, their continuously reinforced concrete : pavement (CRCP) design proce...

  2. Empirical Design of Scour Protections around Monopile Foundations

    DEFF Research Database (Denmark)

    De Vos, L.; De Rouck, J.; Troch, P.

    2012-01-01

    economical design is obtained. This paper describes the derivation of a dynamic design formula to calculate the required stone size for a scour protection around a monopile foundation in a combined wave and current climate. The formula is based on the results of an experimental model study, described......When building offshore wind turbines, a static scour protection is typically designed, allowing no movement of top layer stones under design conditions, leading to an often conservative design. Furthermore, little design guidelines exist for a scour protection around a monopile foundation under...

  3. Decoupling Coupled Constraints Through Utility Design

    Energy Technology Data Exchange (ETDEWEB)

    Li, N; Marden, JR

    2014-08-01

    Several multiagent systems exemplify the need for establishing distributed control laws that ensure the resulting agents' collective behavior satisfies a given coupled constraint. This technical note focuses on the design of such control laws through a game-theoretic framework. In particular, this technical note provides two systematic methodologies for the design of local agent objective functions that guarantee all resulting Nash equilibria optimize the system level objective while also satisfying a given coupled constraint. Furthermore, the designed local agent objective functions fit into the framework of state based potential games. Consequently, one can appeal to existing results in game-theoretic learning to derive a distributed process that guarantees the agents will reach such an equilibrium.

  4. The Utility of Single Subject Design Research

    Science.gov (United States)

    Bennett, Kyle D.

    2016-01-01

    Single subject design (SSD) research is a quantitative approach used to investigate basic and applied research questions. It has been used for decades to examine issues of social importance such as those related to general and special education strategies, therapeutic approaches in mental health, community health practices, safety, and business…

  5. Computer implemented empirical mode decomposition method apparatus, and article of manufacture utilizing curvature extrema

    Science.gov (United States)

    Huang, Norden Eh (Inventor); Shen, Zheng (Inventor)

    2003-01-01

    A computer implemented physical signal analysis method is includes two essential steps and the associated presentation techniques of the results. All the steps exist only in a computer: there are no analytic expressions resulting from the method. The first step is a computer implemented Empirical Mode Decomposition to extract a collection of Intrinsic Mode Functions (IMF) from nonlinear, nonstationary physical signals based on local extrema and curvature extrema. The decomposition is based on the direct extraction of the energy associated with various intrinsic time scales in the physical signal. Expressed in the IMF's, they have well-behaved Hilbert Transforms from which instantaneous frequencies can be calculated. The second step is the Hilbert Transform. The final result is the Hilbert Spectrum. Thus, the invention can localize any event on the time as well as the frequency axis. The decomposition can also be viewed as an expansion of the data in terms of the IMF's. Then, these IMF's, based on and derived from the data, can serve as the basis of that expansion. The local energy and the instantaneous frequency derived from the IMF's through the Hilbert transform give a full energy-frequency-time distribution of the data which is designated as the Hilbert Spectrum.

  6. The content and design of Web sites : an empirical study

    NARCIS (Netherlands)

    Huizingh, EKRE

    2000-01-01

    To support the emergence of a solid knowledge base for analyzing Web activity, we have developed a framework to analyze and categorize the capabilities of Web sites. This distinguishes content from design. Content refers to the information, features, or services that are offered in the Web site,

  7. Empirical Statistical Power for Testing Multilocus Genotypic Effects under Unbalanced Designs Using a Gibbs Sampler

    Directory of Open Access Journals (Sweden)

    Chaeyoung Lee

    2012-11-01

    Full Text Available Epistasis that may explain a large portion of the phenotypic variation for complex economic traits of animals has been ignored in many genetic association studies. A Baysian method was introduced to draw inferences about multilocus genotypic effects based on their marginal posterior distributions by a Gibbs sampler. A simulation study was conducted to provide statistical powers under various unbalanced designs by using this method. Data were simulated by combined designs of number of loci, within genotype variance, and sample size in unbalanced designs with or without null combined genotype cells. Mean empirical statistical power was estimated for testing posterior mean estimate of combined genotype effect. A practical example for obtaining empirical statistical power estimates with a given sample size was provided under unbalanced designs. The empirical statistical powers would be useful for determining an optimal design when interactive associations of multiple loci with complex phenotypes were examined.

  8. Empirical Design of Scour Protections around Monopile Foundations

    DEFF Research Database (Denmark)

    De Vos, L.; De Rouck, J.; Troch, P.

    2011-01-01

    Together with new opportunities, offshore wind farms raise new engineering challenges. An important aspect relates to the erosion of bottom material around the foundation of the wind turbines, caused by the local increase of the wave and current induced flow velocities by the pile's presence....... Typically, the expected scour has a considerable impact on the stability and dynamic behavior of the wind turbine and a scour protection is placed to avoid erosion of the soil close to the foundation. Although much experience exists on the design of scour protections around bridge piers (which are placed...

  9. Semi-empirical system scaling rules for DWDM system design.

    Science.gov (United States)

    DeMuth, Brian; Frankel, Michael Y; Pelekhaty, Vladimir

    2012-01-30

    Recently, several theoretical papers have derived relationships for fiber-optic transmission system performance in terms of associated physical layer parameters. At the same time, a large number of detailed experiments have been and continue being performed that demonstrate increasing capacities and unregenerated reach. We use this wealth of experimental data to validate the aforementioned relationships, and to propose a set of simple scaling rules for performance. We find that, despite substantial differences in experimental configurations, overall performance in terms of spectral efficiency and unregenerated reach is well explained by scaling rules. These scaling rules will be useful to carriers seeking to understand what they should expect to see in terms of network performance using deployed or easily accessible technology, which may be radically different from hero experiment results. These rules will also be useful to design engineers seeking cost effective tradeoffs to achieving higher performance using realistic upgrade strategies, and what might be encountered as a fundamental limit.

  10. Treatment Utility of Functional versus Empiric Assessment within Consultation for Reading Problems

    Science.gov (United States)

    Beavers, Karen F.; Kratochwill, Thomas R.; Braden, Jeffery P.

    2004-01-01

    In this study, 18 teachers and 32 of their students who had reading difficulties were randomly assigned to one of two assessment conditions. In the functional assessment condition, consultants identified functional relationships among environmental events and targeted reading behaviors to develop an intervention plan. In the empiric condition,…

  11. Supervisory Adaptive Network-Based Fuzzy Inference System (SANFIS Design for Empirical Test of Mobile Robot

    Directory of Open Access Journals (Sweden)

    Yi-Jen Mon

    2012-10-01

    Full Text Available A supervisory Adaptive Network-based Fuzzy Inference System (SANFIS is proposed for the empirical control of a mobile robot. This controller includes an ANFIS controller and a supervisory controller. The ANFIS controller is off-line tuned by an adaptive fuzzy inference system, the supervisory controller is designed to compensate for the approximation error between the ANFIS controller and the ideal controller, and drive the trajectory of the system onto a specified surface (called the sliding surface or switching surface while maintaining the trajectory onto this switching surface continuously to guarantee the system stability. This SANFIS controller can achieve favourable empirical control performance of the mobile robot in the empirical tests of driving the mobile robot with a square path. Practical experimental results demonstrate that the proposed SANFIS can achieve better control performance than that achieved using an ANFIS controller for empirical control of the mobile robot.

  12. Design of subjects training on reactor simulator and feasibility study - toward the empirical evaluation of interface design concept

    International Nuclear Information System (INIS)

    Yamaguchi, Y.; Furukawa, H.; Tanabe, F.

    1998-01-01

    On-going JAERI's project for empirical evaluation of the ecological interface design concept was first described. The empirical evaluation is planned to be proceeded through three consecutive steps; designing and actual implementation of the interface on reactor simulator, verification of the interface created, and the validation by the simulator experiment. For conducting the project, three different experimental resources are prerequisite, that are, data analysis method for identifying the operator's strategies, experimental facility including reactor simulator, and experimental subjects or subjects training method. Among the three experimental resources, subjects training method was recently designed and a simulator experiment was earned out in order to examine the feasibility of the designed training method. From the experiment and analysis of the experimental records, we could conclude that it is feasible that the experimental subjects having an appropriate technical basis can gain the sufficient competence for evaluation work of the interface design concept by using the training method designed. (author)

  13. An anthology of theories and models of design philosophy, approaches and empirical explorations

    CERN Document Server

    Blessing, Lucienne

    2014-01-01

    While investigations into both theories and models has remained a major strand of engineering design research, current literature sorely lacks a reference book that provides a comprehensive and up-to-date anthology of theories and models, and their philosophical and empirical underpinnings; An Anthology of Theories and Models of Design fills this gap. The text collects the expert views of an international authorship, covering: ·         significant theories in engineering design, including CK theory, domain theory, and the theory of technical systems; ·         current models of design, from a function behavior structure model to an integrated model; ·         important empirical research findings from studies into design; and ·         philosophical underpinnings of design itself. For educators and researchers in engineering design, An Anthology of Theories and Models of Design gives access to in-depth coverage of theoretical and empirical developments in this area; for pr...

  14. Regulatory risk in the utilities industry: An empirical study of the English-speaking countries

    International Nuclear Information System (INIS)

    Gaggero, Alberto A.

    2007-01-01

    The economic theory on regulation suggests that firms subject to incentive regulation, such as price cap, bear more risk than firms subject to cost plus regulation, such as rate of return regulation. This hypothesis is tested empirically using a sample of 93 regulated companies operating in six English-speaking countries: Australia, Canada, Ireland, New Zealand, UK and USA, during the period 1995-2004. I replicate the methodology of the existing literature and also apply panel data techniques to my sample. The results obtained do not support the hypothesis that price cap regulation imposes more risk. (author)

  15. Model Selection for Equating Testlet-Based Tests in the NEAT Design: An Empirical Study

    Science.gov (United States)

    He, Wei; Li, Feifei; Wolfe, Edward W.; Mao, Xia

    2012-01-01

    For those tests solely composed of testlets, local item independency assumption tends to be violated. This study, by using empirical data from a large-scale state assessment program, was interested in investigates the effects of using different models on equating results under the non-equivalent group anchor-test (NEAT) design. Specifically, the…

  16. Gathering Empirical Evidence Concerning Links between Computer Aided Design (CAD) and Creativity

    Science.gov (United States)

    Musta'amal, Aede Hatib; Norman, Eddie; Hodgson, Tony

    2009-01-01

    Discussion is often reported concerning potential links between computer-aided designing and creativity, but there is a lack of systematic enquiry to gather empirical evidence concerning such links. This paper reports an indication of findings from other research studies carried out in contexts beyond general education that have sought evidence…

  17. Revision of the South African flexible pavement design method; mechanistic-empirical components

    CSIR Research Space (South Africa)

    Theyse, HL

    2007-09-01

    Full Text Available The current version of the South African Mechanistic –Empirical Design Method for flexible pavements is based on technology and models developed during the 1970’s and 1980’s. Given the current level of concern regarding the validity of the results...

  18. An Empirical Algorithm for Power Analysis in Deep Submicron Electronic Designs

    Directory of Open Access Journals (Sweden)

    May Huang

    2002-01-01

    Full Text Available An empirical algorithm applied to logic level power analysis in deep submicron VLSI designs is introduced in the paper. The method explores a static analysis strategy using unit functions to represent signal transitions. It can be extended to the use of a Register Transfer Level (RTL power analysis after RTL codes are translated to Boolean equations. A new method for representing state-dependent power models is also introduced in the paper to reduce the complexity of power modeling and to improve the performance of power analysis. The modeling method supports not only the empirical power analysis, but also general simulation-based power analysis methods.

  19. Synthesis and Design of a Sustainable CO2 Utilization Network

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Gani, Rafiqul

    a superstructure-based approach a network of utilization alternatives is created linking CO2 and other raw materials with various products using processing blocks. This will then be optimized and verified for sustainability. Detailed design has also been performed for a case study on the methanol synthesis...... and requires work for implementation at an industrial level. One aspect of this is the development of a methodology for the formulation and optimization of sustainable conversion processes. This methodology follows three stages for the process synthesis, design and more sustainable design. Using...

  20. Utility-Scale Solar 2015: An Empirical Analysis of Project Cost, Performance, and Pricing Trends in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division; Seel, Joachim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division

    2016-08-17

    The utility-scale solar sector—defined here to include any ground-mounted photovoltaic (“PV”), concentrating photovoltaic (“CPV”), or concentrating solar power (“CSP”) project that is larger than 5 MWAC in capacity—has led the overall U.S. solar market in terms of installed capacity since 2012. It is expected to maintain its market-leading position for at least another five years, driven in part by December 2015’s three-year extension of the 30% federal investment tax credit (“ITC”) through 2019 (coupled with a favorable switch to a “start construction” rather than a “placed in service” eligibility requirement, and a gradual phase down of the credit to 10% by 2022). In fact, in 2016 alone, the utility-scale sector is projected to install more than twice as much new capacity as it ever has previously in a single year. This unprecedented boom makes it difficult, yet more important than ever, to stay abreast of the latest utility-scale market developments and trends. This report—the fourth edition in an ongoing annual series—is intended to help meet this need, by providing in-depth, annually updated, data-driven analysis of the utility-scale solar project fleet in the United States. Drawing on empirical project-level data from a wide range of sources, this report analyzes not just installed project costs or prices—i.e., the traditional realm of most solar economic analyses—but also operating costs, capacity factors, and power purchase agreement (“PPA”) prices from a large sample of utility-scale solar projects throughout the United States. Given its current dominance in the market, utility-scale PV also dominates much of this report, though data from CPV and CSP projects are also presented where appropriate.

  1. Utility-Scale Solar 2014. An Empirical Analysis of Project Cost, Performance, and Pricing Trends in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Seel, Joachim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-09-01

    Other than the nine Solar Energy Generation Systems (“SEGS”) parabolic trough projects built in the 1980s, virtually no large-scale or “utility-scale” solar projects – defined here to include any groundmounted photovoltaic (“PV”), concentrating photovoltaic (“CPV”), or concentrating solar thermal power (“CSP”) project larger than 5 MWAC – existed in the United States prior to 2007. By 2012 – just five years later – utility-scale had become the largest sector of the overall PV market in the United States, a distinction that was repeated in both 2013 and 2014 and that is expected to continue for at least the next few years. Over this same short period, CSP also experienced a bit of a renaissance in the United States, with a number of large new parabolic trough and power tower systems – some including thermal storage – achieving commercial operation. With this critical mass of new utility-scale projects now online and in some cases having operated for a number of years (generating not only electricity, but also empirical data that can be mined), the rapidly growing utility-scale sector is ripe for analysis. This report, the third edition in an ongoing annual series, meets this need through in-depth, annually updated, data-driven analysis of not just installed project costs or prices – i.e., the traditional realm of solar economics analyses – but also operating costs, capacity factors, and power purchase agreement (“PPA”) prices from a large sample of utility-scale solar projects in the United States. Given its current dominance in the market, utility-scale PV also dominates much of this report, though data from CPV and CSP projects are presented where appropriate.

  2. Research reactor design and utilization: the Korean experience

    International Nuclear Information System (INIS)

    JUN BYUNG-JIN; PARK CHEOL; KIM HARK-RHO

    2008-01-01

    HANARO is the first high power research reactor in Korea designed by Korean technology with specific requirements for its utilization. Since the construction and operation of multiple research reactors would have been almost impossible when considering the circumstances at the time of its initiation, we designed the HANARO for as many purposes as possible to satisfy future national demands for the 21st century. Installation of a majority of the experimental instruments and facilities, to fully utilize the reactor, followed its commissioning and initial operation. Some of them are still being developed and installed, and the reactor is capable of accommodating more instruments in the future. Under a limited national condition, one should proceed in a step-by-step manner but pursue a high performance of a reactor and its instruments. Existence of a high performance reactor is the starting point to attract users, and thus establishing a system for a nation-wide utilization of the reactor is indispensable. Now the system selects the required instruments with priorities. As the investment of the government accumulates and the user society grows, a request for a self reliance has become stronger. For a gradual approach, all the reactor systems should be carefully designed by considering future additional installations. A provision should also be made at the reactor design stage for the self reliance of a reactor operation for its long term survival. (author)

  3. RESEARCH UTILIZATION IN THE DESIGN DECISION MAKING PROCESS

    Directory of Open Access Journals (Sweden)

    Amy Huber

    2016-04-01

    Full Text Available This article summarizes findings from a national survey of interior design practitioners in the United States (N=366.  The study explored interior design practitioners' current preferences for conducting project research including: activities conducted and sources used, attraction to and recall from sources, and ideas for communicating research findings. Responses suggest that interior designers do value research, yet have little time to utilize research. While cross-tabulation analyses indicate no major differences in research activities between the study’s demographic groups, collectively, only 12% of the sample indicated they utilized academic journals and, at times, even incorrectly identified those sources. Open-ended responses allowed designers to offer ideas for communicating research and four key themes emerged, including: topic selection and relevancy, ideas for new dissemination methods, ideas for presentation style, and perceptions of the written language used.  It is hoped that this study’s findings may help design researchers better communicate their own findings to design practitioners.

  4. The utility of an empirically derived co-activation ratio for muscle force prediction through optimization.

    Science.gov (United States)

    Brookham, Rebecca L; Middlebrook, Erin E; Grewal, Tej-jaskirat; Dickerson, Clark R

    2011-05-17

    Biomechanical optimization models that apply efficiency-based objective functions often underestimate or negate antagonist co-activation. Co-activation assists movement control, joint stabilization and limb stiffness and should be carefully incorporated into models. The purposes of this study were to mathematically describe co-activation relationships between elbow flexors and extensors during isometric exertions at varying intensity levels and postures, and secondly, to apply these co-activation relationships as constraints in an optimization muscle force prediction model of the elbow and assess changes in predictions made while including these constraints. Sixteen individuals performed 72 isometric exertions while holding a load in their right hand. Surface EMG was recorded from elbow flexors and extensors. A co-activation index provided a relative measure of flexor contribution to total activation about the elbow. Parsimonious models of co-activation during flexion and extension exertions were developed and added as constraints to a muscle force prediction model to enforce co-activation. Three different PCSA data sets were used. Elbow co-activation was sensitive to changes in posture and load. During flexion exertions the elbow flexors were activated about 75% MVC (this amount varied according to elbow angle, shoulder flexion and abduction angles, and load). During extension exertions the elbow flexors were activated about 11% MVC (this amount varied according to elbow angle, shoulder flexion angle and load). The larger PCSA values appeared to be more representative of the subject pool. Inclusion of these co-activation constraints improved the model predictions, bringing them closer to the empirically measured activation levels. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Utility Green Pricing Programs: Design, Implementation, and Consumer Response

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Swezey, B.; Aabakken, J.

    2004-02-01

    The term green pricing refers to programs offered by utilities in traditionally regulated electricity markets, which allow customers to support the development of renewable energy sources by paying a small premium on their electric bills. Since the introduction of the concept in the United States, the number of unique utility green pricing programs has expanded from just a few programs in 1993 to more than 90 in 2002. About 10% of U.S. utilities offered a green pricing option to about 26 million consumers by the end of 2002. This report provides: (1) aggregate industry data on consumer response to utility programs, which indicate the collective impact of green pricing on renewable energy development nationally; and (2) market data that can be used by utilities as a benchmark for gauging the relative success of their green pricing programs. Specifically, the paper presents current data and trends in consumer response to green pricing, as measured by renewable energy sales, participants, participation rates, and new renewable energy capacity supported. It presents data on various aspects of program design and implementation, such as product pricing, ownership of supplies, retention rates, marketing costs, the effectiveness of marketing techniques, and methods of enrolling and providing value to customers.

  6. Evaluation of current Louisiana flexible pavement structures using PMS data and new mechanistic-empirical pavement design guide : tech summary.

    Science.gov (United States)

    2012-04-01

    The new Mechanistic-Empirical Pavement Design Guide (MEPDG) developed under the National Cooperative Highway : Research Program (NCHRP) Project 1-37A represents a major change as compared to the 1993 AASHTO Pavement : Design Guide. MEPDG provides a r...

  7. Aerodynamic Design Optimisation for Utility Helicopter Drag Reduction

    OpenAIRE

    Grawunder, Moritz

    2017-01-01

    In order to reduce helicopter’s fuel flow requirements and emissions, the aerodynamic design of Twin-Engine-Light (TEL) class utility helicopter is revised. A viable approach for achieving efficiency gains is reducing the helicopter’s parasite drag. This is achieved by the development of aerodynamic fairings for the skid-landing-gear and passive flow control devices at the rear fuselage. On aggregate, a parasite drag benefit of 22% is achieved, which corresponds to about 10% fuel flow reducti...

  8. Applying Semiotic Theories to Graphic Design Education: An Empirical Study on Poster Design Teaching

    Science.gov (United States)

    Yang, Chao-Ming; Hsu, Tzu-Fan

    2015-01-01

    The rationales behind design are dissimilar to those behind art. Establishing an adequate theoretical foundation for conducting design education can facilitate scientising design methods. Thus, from the perspectives of the semiotic theories proposed by Saussure and Peirce, we investigated graphic design curricula by performing teaching…

  9. Merged ontology for engineering design: Contrasting empirical and theoretical approaches to develop engineering ontologies

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Storga, M

    2009-01-01

    This paper presents a comparison of two previous and separate efforts to develop an ontology in the engineering design domain, together with an ontology proposal from which ontologies for a specific application may be derived. The research contrasts an empirical, user-centered approach to develop...... that is theoretically sound and another that is applicable, is recognized and argued. Finally, the merged ontology for engineering design is proposed as a template ontology that can be tailored by researchers and practitioners for a specific context....

  10. Design models as emergent features: An empirical study in communication and shared mental models in instructional

    Directory of Open Access Journals (Sweden)

    Lucca Botturi

    2006-06-01

    Full Text Available This paper reports the results of an empirical study that investigated the instructional design process of three teams involved in the development of an e-learning unit. The teams declared they were using the same fast-prototyping design and development model, and were composed of the same roles (although with a different number of SMEs. Results indicate that the design and development model actually informs the activities of the group, but that it is interpreted and adapted by the team for the specific project. Thus, the actual practice model of each team can be regarded as an emergent feature. This analysis delivers insights concerning issues about team communication, shared understanding, individual perspectives and the implementation of prescriptive instructional design models.

  11. Value-based insurance design: benefits beyond cost and utilization.

    Science.gov (United States)

    Gibson, Teresa B; Maclean, Ross J; Chernew, Michael E; Fendrick, A Mark; Baigel, Colin

    2015-01-01

    As value-based insurance design (VBID) programs proliferate, evidence is emerging on the impact of VBID. To date, studies have largely measured VBID impact on utilization, and a few studies have assessed its impact on quality, outcomes, and cost. In this commentary we discuss these domains, summarize evidence, and propose the extension of measurement of VBID impact into areas including workplace productivity and quality of life, employee and patient engagement, and talent attraction and retention. We contend that VBID evaluations should consider a broad variety of programmatic dividends on both humanistic and health-related outcomes.

  12. Which events can cause iteration in instructional design? An empirical study of the design process

    NARCIS (Netherlands)

    Verstegen, D.M.L.; Barnard, Y.F.; Pilot, A.

    2006-01-01

    Instructional design is not a linear process: designers have to weigh the advantages and disadvantages of alternative solutions, taking into account different kinds of conflicting and changing constraints. To make sure that they eventually choose the most optimal one, they have to keep on collecting

  13. Partnership effectiveness in primary community care networks: A national empirical analysis of partners' coordination infrastructure designs.

    Science.gov (United States)

    Lin, Blossom Yen-Ju; Lin, Yung-Kai; Lin, Cheng-Chieh

    2010-01-01

    Previous empirical and managerial studies have ignored the effectiveness of integrated health networks. It has been argued that the varying definitions and strategic imperatives of integrated organizations may have complicated the assessment of the outcomes/performance of varying models, particularly when their market structures and contexts differed. This study aimed to empirically verify a theoretical perspective on the coordination infrastructure designs and the effectiveness of the primary community care networks (PCCNs) formed and funded by the Bureau of National Health Insurance since March 2003. The PCCNs present a model to replace the traditional fragmented providers in Taiwan's health care. The study used a cross-sectional mailed survey designed to ascertain partnership coordination infrastructure and integration of governance, clinical care, bonding, finances, and information. The outcome indicators were PCCNs' perceived performance and willingness to remain within the network. Structural equation modeling examined the causal relationships, controlling for organizational and environmental factors. Primary data collection occurred from February through December 2005, via structured questionnaires sent to 172 PCCNs. Using the individual PCCN as the unit of analysis, the results found that a network's efforts regarding coordination infrastructures were positively related to the PCCN's perceived performance and willingness to remain within the network. In addition, PCCNs practicing in rural areas and in areas with higher density of medical resources had better perceived effectiveness and willingness to cooperate in the network.Practical Implication: The lack of both an operational definition and an information about system-wide integration may have obstructed understanding of integrated health networks' organizational dynamics. This study empirically examined individual PCCNs and offers new insights on how to improve networks' organizational design and

  14. Daylight Influence on Colour Design : Empirical Study on Perceived Colour and Colour Experience Indoors

    OpenAIRE

    Hårleman, Maud

    2007-01-01

    It is known that one and the same interior colouring will appear different in rooms with windows facing north or facing south, but it is not known how natural daylight from these two compass points affects perceived colour and the ways in which colour is experienced. The objective is to describe the perceived colours to be expected in rooms with sunlight and diffused light, and thus develop a tool for colour design. Two empirical investigations provide the basis for six attached papers. The m...

  15. A Guide to Visual Multi-Level Interface Design From Synthesis of Empirical Study Evidence

    CERN Document Server

    Lam, Heidi

    2010-01-01

    Displaying multiple levels of data visually has been proposed to address the challenge of limited screen space. Although many previous empirical studies have addressed different aspects of this question, the information visualization research community does not currently have a clearly articulated consensus on how, when, or even if displaying data at multiple levels is effective. To shed more light on this complex topic, we conducted a systematic review of 22 existing multi-level interface studies to extract high-level design guidelines. To facilitate discussion, we cast our analysis findings

  16. Characterization of cementitiously stabilized subgrades for mechanistic-empirical pavement design

    Science.gov (United States)

    Solanki, Pranshoo

    Pavements are vulnerable to subgrade layer performance because it acts as a foundation. Due to increase in the truck traffic, pavement engineers are challenged to build more strong and long-lasting pavements. To increase the load-bearing capacity of pavements, subgrade layer is often stabilized with cementitious additives. Thus, an overall characterization of stabilized subgrade layer is important for enhanced short- and long-term pavement performance. In this study, the effect of type and amount of additive on the short-term performance in terms of material properties recommended by the new Mechanistic-Empirical Pavement Design Guide (MEPDG) is examined. A total of four soils commonly encountered as subgrades in Oklahoma are utilized. Results show that the changes in the Mr, ME and UCS values stabilized specimens depend on the soil type and properties of additives. The long-term performance (or durability) of stabilized soil specimens is investigated by conducting freeze-thaw (F-T) cycling, vacuum saturation and tube suction tests on 7-day cured P-, K- and C-soil specimens stabilized with 6% lime, 10% CFA and 10% CKD. This study is motivated by the fact that during the service life of pavement stabilized layers are subjected to F-T cycles and moisture variations. It is found that that UCS value of all the stabilized specimens decreased with increase in the number of F-T cycles. A strong correlation was observed between UCS values retained after vacuum saturation and F-T cycles indicating that vacuum saturation could be used as a time-efficient and inexpensive method for evaluating durability of stabilized soils. In this study, short- and long-term observations from stabilization of sulfate bearing soil with locally available low (CFA), moderate (CKD) and high (lime) calcium-based stabilizers are determined to evaluate and compare the effect of additive type on the phenomenon of sulfate-induced heave. The impact of different factors on the development of the

  17. An Empirical Study on Design Partner Selection in Green Product Collaboration Design

    Directory of Open Access Journals (Sweden)

    Aijun Liu

    2018-01-01

    Full Text Available Green production has become an important issue in PCD (Product Collaboration Design for almost every enterprise, and will determine the sustainability of enterprises in the long term. The choice of design partner is a necessary condition in order to achieve green production. For the uncertain, fuzzy, and dynamic information such as unknown indices and weights, fuzzy semantics, and dynamic time factors in GPCD (Green Product Collaboration Design, a two-stage dynamic hybrid MADM (Multi-Attribute Decision Making approach based on fuzzy DEMATEL (Decision-Making and Trial Evaluation Laboratory, fuzzy KMA (Karnik–Mendel Algorithm, and fuzzy VIKOR (VlseKriterjumska Optimizacija I Kompromisno Resenje was proposed. In the first stage, fuzzy DEMATEL was used to determine the evaluation indices. Then, in the second stage, to accurately depict the dynamic information generated by the different phases of a product design, the dynamic evaluation method based on fuzzy theories was employed, and the weights of the indices were calculated by fuzzy KMA, then sorted by fuzzy VIKOR. Finally, a case study and a comparative analysis wre provided to illustrate the effectiveness of the proposed approach.

  18. Aircraft directional stability and vertical tail design: A review of semi-empirical methods

    Science.gov (United States)

    Ciliberti, Danilo; Della Vecchia, Pierluigi; Nicolosi, Fabrizio; De Marco, Agostino

    2017-11-01

    Aircraft directional stability and control are related to vertical tail design. The safety, performance, and flight qualities of an aircraft also depend on a correct empennage sizing. Specifically, the vertical tail is responsible for the aircraft yaw stability and control. If these characteristics are not well balanced, the entire aircraft design may fail. Stability and control are often evaluated, especially in the preliminary design phase, with semi-empirical methods, which are based on the results of experimental investigations performed in the past decades, and occasionally are merged with data provided by theoretical assumptions. This paper reviews the standard semi-empirical methods usually applied in the estimation of airplane directional stability derivatives in preliminary design, highlighting the advantages and drawbacks of these approaches that were developed from wind tunnel tests performed mainly on fighter airplane configurations of the first decades of the past century, and discussing their applicability on current transport aircraft configurations. Recent investigations made by the authors have shown the limit of these methods, proving the existence of aerodynamic interference effects in sideslip conditions which are not adequately considered in classical formulations. The article continues with a concise review of the numerical methods for aerodynamics and their applicability in aircraft design, highlighting how Reynolds-Averaged Navier-Stokes (RANS) solvers are well-suited to attain reliable results in attached flow conditions, with reasonable computational times. From the results of RANS simulations on a modular model of a representative regional turboprop airplane layout, the authors have developed a modern method to evaluate the vertical tail and fuselage contributions to aircraft directional stability. The investigation on the modular model has permitted an effective analysis of the aerodynamic interference effects by moving, changing, and

  19. Sustainable DME synthesis-design with CO2 utilization

    DEFF Research Database (Denmark)

    Prasertsri, Weeranut; Frauzem, Rebecca; Suriyapraphadilok, Uthaiporn

    valuable chemical that can be produced via thermochemical CO2 conversion reactions. The aim of this study is to identify the most promising processing route for sustainable production of DME in terms of CO2 emission, economic indicators and sustainable indicators. The three processing routes are generated......Minimizing CO2 emission, while achieving economic feasibility in CO2 utilization for producing valuable chemicals is a challenging problem, as reported in recent studies.Due to its high Cetane number, clean-burning, and non-toxic, DME is a promising fuel alternative, and therefore, potentially......: (A) dry reforming step, methanol synthesis step, and methanoldehydration step; (B) CO2 hydrogenation step followed by methanol dehydration step;and (C) dry reforming step followed by direct DME synthesis step. Starting with a base-case design, the process flow sheets for the three routes are studied...

  20. Design of Tomato Drying System by Utilizing Brine Geothermal

    Science.gov (United States)

    Afuar, W.; Sibarani, B.; Abdurrahman, G.; Hendrarsakti, J.

    2016-09-01

    Cultivation of tomato plants in Indonesia has been started since 1961.Tomatoes generally will rot in three days if left on storage. Moreover, low quality tomatoes have cheaper price. After harvested, tomatoes need to be treated by drying process so it can last longer. Energy for drying tomatoes can be obtained by utilizing heat from geothermal brine. Purpose of this research is to design a tomato drying system by extracting heat of geothermal brine from separator with certain flow rate to heat up water by using a heat exchanger. Furthermore, this water will be used to heat up the surrounding air which is circulated by blower system to heat up the tomatoes chamber. Tomatoes drying process needs temperature range of 50-70°C to evaporate water content from 95.7% to 26%. After that treatment, the tomatoes are expected to have better durability. The objective of this study is to determine the quantity of hot brine which is needed for drying tomatoes and to design a drying system so that tomatoes can last longer.

  1. Design and experimentation of an empirical multistructure framework for accurate, sharp and reliable hydrological ensembles

    Science.gov (United States)

    Seiller, G.; Anctil, F.; Roy, R.

    2017-09-01

    This paper outlines the design and experimentation of an Empirical Multistructure Framework (EMF) for lumped conceptual hydrological modeling. This concept is inspired from modular frameworks, empirical model development, and multimodel applications, and encompasses the overproduce and select paradigm. The EMF concept aims to reduce subjectivity in conceptual hydrological modeling practice and includes model selection in the optimisation steps, reducing initial assumptions on the prior perception of the dominant rainfall-runoff transformation processes. EMF generates thousands of new modeling options from, for now, twelve parent models that share their functional components and parameters. Optimisation resorts to ensemble calibration, ranking and selection of individual child time series based on optimal bias and reliability trade-offs, as well as accuracy and sharpness improvement of the ensemble. Results on 37 snow-dominated Canadian catchments and 20 climatically-diversified American catchments reveal the excellent potential of the EMF in generating new individual model alternatives, with high respective performance values, that may be pooled efficiently into ensembles of seven to sixty constitutive members, with low bias and high accuracy, sharpness, and reliability. A group of 1446 new models is highlighted to offer good potential on other catchments or applications, based on their individual and collective interests. An analysis of the preferred functional components reveals the importance of the production and total flow elements. Overall, results from this research confirm the added value of ensemble and flexible approaches for hydrological applications, especially in uncertain contexts, and open up new modeling possibilities.

  2. Computational design of hepatitis C vaccines using empirical fitness landscapes and population dynamics

    Science.gov (United States)

    Hart, Gregory; Ferguson, Andrew

    Hepatitis C virus (HCV) afflicts 170 million people and kills 350,000 annually. Vaccination offers the most realistic and cost effective hope of controlling this epidemic. Despite 25 years of research, no vaccine is available. A major obstacle is the virus' extreme genetic variability and rapid mutational escape from immune pressure. Improvements in the vaccine design process are urgently needed. Coupling data mining and maximum entropy inference, we have developed a computational approach to translate sequence databases into empirical fitness landscapes. These landscapes explicitly connect viral genotype to phenotypic fitness and reveal vulnerable targets that can be exploited to rationally design vaccines. These landscapes represent the mutational ''playing field'' over which the virus evolves. We have integrated them with agent-based models of the viral mutational and host immune response, establishing a data-driven multi-scale immune simulator. We have used this simulator to perform in silico screening of HCV immunogens to rationally design vaccines to both cripple viral fitness and block escape. By systematically identifying a small number of promising vaccine candidates, these models can accelerate the search for a vaccine by massively reducing the experimental search space.

  3. Utility-Scale Solar 2016: An Empirical Analysis of Project Cost, Performance, and Pricing Trends in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Bolinger, Mark; Seel, Joachim; LaCommare, Kristina Hamachi

    2017-09-19

    The utility-scale solar sector has led the overall U.S. solar market in terms of installed capacity since 2012. In 2016, the utility-scale sector installed more than 2.5 times as much new capacity as did the residential and commercial sectors combined, and is expected to maintain its dominant position for at least another five years. This report—the fifth edition in an ongoing annual series—provides data-driven analysis of the utility-scale solar project fleet in the United States. We analyze not just installed project prices, but also operating costs, capacity factors, and power purchase agreement ("PPA") prices from a large sample of utility-scale PV and CSP projects throughout the United States. Highlights from this year's edition include the following: Installation Trends: The use of solar tracking devices dominated 2016 installations, at nearly 80% of all new capacity. In a reflection of the ongoing geographic expansion of the market beyond California and the Southwest, the median long-term average insolation level at newly built project sites declined again in 2016. While new fixed-tilt projects are now seen predominantly in less-sunny regions, tracking projects are increasingly pushing into these same regions. The median inverter loading ratio has stabilized in 2016 at 1.3 for both tracking and fixed-tilt projects. Installed Prices: Median installed PV project prices within a sizable sample have fallen by two-thirds since the 2007-2009 period, to $2.2/WAC (or $1.7/WDC) for projects completed in 2016. The lowest 20th percentile of projects within our 2016 sample were priced at or below $2.0/WAC, with the lowest-priced projects around $1.5/WAC. Overall price dispersion across the entire sample and across geographic regions decreased significantly in 2016. Operation and Maintenance (“O&M”) Costs: What limited empirical O&M cost data are publicly available suggest that PV O&M costs were in the neighborhood of $18/kWAC-year, or $8/MWh, in 2016. These

  4. Impact of Globalization on Higher Education: An Empirical Study of Education Policy & Planning of Design Education in Hong Kong

    Science.gov (United States)

    Lam, Yan Yan

    2010-01-01

    This paper focuses on the impact of globalization in the domain of higher education, particularly, design education. It reviews how globalization may affect educational policy and planning in Hong Kong by drawing on an empirical study involving senior management, a course leader and a design trainer/facilitator. This paper not only illustrates the…

  5. Evaluation of current Louisiana flexible pavement structures using PMS data and new mechanistic-empirical pavement design guide.

    Science.gov (United States)

    2012-04-01

    The new Mechanistic-Empirical Pavement Design Guide (MEPDG) developed under the National Cooperative Highway Research Program (NCHRP) Project 1-37A represents a major change as compared to the 1993 AASHTO Pavement Design Guide. The MEPDG provides a r...

  6. Synthetic strong ground motions for engineering design utilizing empirical Green`s functions

    Energy Technology Data Exchange (ETDEWEB)

    Hutchings, L.J.; Jarpe, S.P.; Kasameyer, P.W.; Foxall, W.

    1996-04-11

    We present a methodology for developing realistic synthetic strong ground motions for specific sites from specific earthquakes. We analyzed the possible ground motion resulting from a M = 7.25 earthquake that ruptures 82 km of the Hayward fault for a site 1.4 km from the fault in the eastern San Francisco Bay area. We developed a suite of 100 rupture scenarios for the Hayward fault earthquake and computed the corresponding strong ground motion time histories. We synthesized strong ground motion with physics-based solutions of earthquake rupture and applied physical bounds on rupture parameters. By having a suite of rupture scenarios of hazardous earthquakes for a fixed magnitude and identifying the hazard to the site from the statistical distribution of engineering parameters, we introduce a probabilistic component into the deterministic hazard calculation. Engineering parameters of synthesized ground motions agree with those recorded from the 1995 Kobe, Japan and the 1992 Landers, California earthquakes at similar distances and site geologies.

  7. Mortality monitoring design for utility-scale solar power facilities

    Science.gov (United States)

    Huso, Manuela; Dietsch, Thomas; Nicolai, Chris

    2016-05-27

    unique conditions encountered at solar facilities. In particular, unlike at wind-power facilities, the unimpeded access to almost all areas within the facilities, the typically flat terrain, and general absence of thick vegetation allow distance-sampling techniques (Buckland and others, 2001, 2004) to be exploited to advantage at industrial solar sites. These protocols build on the work of Nicolai and others (2011), and as our understanding and techniques for monitoring improve, the methods may be further modified to incorporate improvements in the future. We present case studies based on monitoring methods currently implemented at different utility-scale solar facilities to illustrate how distance-sampling techniques may improve overall detectability without substantially increasing costs. Every facility is unique, and the protocols presented may be adapted based on specific monitoring objectives and conditions at each site.We provide guidance for designing monitoring programs whose objective it is to estimate the total number of bird and bat fatalities occurring at a facility over an extended period of time. We address spatial variation in causes of mortality, as well as potential sources of imperfect detection, for example, animals falling in or moving to unsearched areas, carcasses removed by predators, and carcasses missed by searchers. We suggest methods to estimate and account for each source of imperfect detection. This document focuses on monitoring design only and does not discuss approaches for estimating mortality from collected data. The development of statistically sound estimators relevant to the solar context is a current topic of research, although there are already strong foundations for estimation with distance-sampling methods in similar open, arid environments (Anderson and others, 2001; Freilich and others, 2005). Nonetheless, if protocols described in this document are followed, the resulting data will be adequate and sufficient for estimating

  8. Empirical approach for designing of support system in mechanized coal pillar mining

    Energy Technology Data Exchange (ETDEWEB)

    Kushwaha, A.; Singh, S.K.; Tewari, S.; Sinha, A. [Central Institute of Mining & Fuel Research, Dhanbad (India)

    2010-10-15

    Mechanized room-and-pillar system of coal pillar mining using side dump loading machine or load haul dumper machine, or by continuous miner, is the presently most dominant under ground method of extraction in India. Under this method of extraction, strata control is a major problem affecting safety and productivity of the mine. As per existing Director General of Mine Safety guidelines, systematic support rules must be followed at the depillaring faces irrespective of immediate roof rock type and competency. Therefore, there is a high chance that sometimes these systematic support rules give unnecessarily high support, or sometimes inadequate support, which may lead to roof failure at the face. As a result, there is a big loss of life and material including coal in terms of left-outribs/stooks and other associated mining equipment deployed at the faces. Therefore, in the present paper, authors attempted to develop generalized empirical equations for estimating the required support load density at different places of the face based on geotechnical parameters of the mine and physico-mechanical properties of the immediate roof rocks for designing of support system during mechanized coal pillar mining.

  9. Recommended survey designs for occupancy modelling using motion-activated cameras: insights from empirical wildlife data

    Directory of Open Access Journals (Sweden)

    Graeme Shannon

    2014-08-01

    Full Text Available Motion-activated cameras are a versatile tool that wildlife biologists can use for sampling wild animal populations to estimate species occurrence. Occupancy modelling provides a flexible framework for the analysis of these data; explicitly recognizing that given a species occupies an area the probability of detecting it is often less than one. Despite the number of studies using camera data in an occupancy framework, there is only limited guidance from the scientific literature about survey design trade-offs when using motion-activated cameras. A fuller understanding of these trade-offs will allow researchers to maximise available resources and determine whether the objectives of a monitoring program or research study are achievable. We use an empirical dataset collected from 40 cameras deployed across 160 km2 of the Western Slope of Colorado, USA to explore how survey effort (number of cameras deployed and the length of sampling period affects the accuracy and precision (i.e., error of the occupancy estimate for ten mammal and three virtual species. We do this using a simulation approach where species occupancy and detection parameters were informed by empirical data from motion-activated cameras. A total of 54 survey designs were considered by varying combinations of sites (10–120 cameras and occasions (20–120 survey days. Our findings demonstrate that increasing total sampling effort generally decreases error associated with the occupancy estimate, but changing the number of sites or sampling duration can have very different results, depending on whether a species is spatially common or rare (occupancy = ψ and easy or hard to detect when available (detection probability = p. For rare species with a low probability of detection (i.e., raccoon and spotted skunk the required survey effort includes maximizing the number of sites and the number of survey days, often to a level that may be logistically unrealistic for many studies. For common

  10. Camera trap arrays improve detection probability of wildlife: Investigating study design considerations using an empirical dataset.

    Directory of Open Access Journals (Sweden)

    Kelly M O'Connor

    Full Text Available Camera trapping is a standard tool in ecological research and wildlife conservation. Study designs, particularly for small-bodied or cryptic wildlife species often attempt to boost low detection probabilities by using non-random camera placement or baited cameras, which may bias data, or incorrectly estimate detection and occupancy. We investigated the ability of non-baited, multi-camera arrays to increase detection probabilities of wildlife. Study design components were evaluated for their influence on wildlife detectability by iteratively parsing an empirical dataset (1 by different sizes of camera arrays deployed (1-10 cameras, and (2 by total season length (1-365 days. Four species from our dataset that represented a range of body sizes and differing degrees of presumed detectability based on life history traits were investigated: white-tailed deer (Odocoileus virginianus, bobcat (Lynx rufus, raccoon (Procyon lotor, and Virginia opossum (Didelphis virginiana. For all species, increasing from a single camera to a multi-camera array significantly improved detection probability across the range of season lengths and number of study sites evaluated. The use of a two camera array increased survey detection an average of 80% (range 40-128% from the detection probability of a single camera across the four species. Species that were detected infrequently benefited most from a multiple-camera array, where the addition of up to eight cameras produced significant increases in detectability. However, for species detected at high frequencies, single cameras produced a season-long (i.e, the length of time over which cameras are deployed and actively monitored detectability greater than 0.75. These results highlight the need for researchers to be critical about camera trap study designs based on their intended target species, as detectability for each focal species responded differently to array size and season length. We suggest that researchers a priori

  11. Camera trap arrays improve detection probability of wildlife: Investigating study design considerations using an empirical dataset.

    Science.gov (United States)

    O'Connor, Kelly M; Nathan, Lucas R; Liberati, Marjorie R; Tingley, Morgan W; Vokoun, Jason C; Rittenhouse, Tracy A G

    2017-01-01

    Camera trapping is a standard tool in ecological research and wildlife conservation. Study designs, particularly for small-bodied or cryptic wildlife species often attempt to boost low detection probabilities by using non-random camera placement or baited cameras, which may bias data, or incorrectly estimate detection and occupancy. We investigated the ability of non-baited, multi-camera arrays to increase detection probabilities of wildlife. Study design components were evaluated for their influence on wildlife detectability by iteratively parsing an empirical dataset (1) by different sizes of camera arrays deployed (1-10 cameras), and (2) by total season length (1-365 days). Four species from our dataset that represented a range of body sizes and differing degrees of presumed detectability based on life history traits were investigated: white-tailed deer (Odocoileus virginianus), bobcat (Lynx rufus), raccoon (Procyon lotor), and Virginia opossum (Didelphis virginiana). For all species, increasing from a single camera to a multi-camera array significantly improved detection probability across the range of season lengths and number of study sites evaluated. The use of a two camera array increased survey detection an average of 80% (range 40-128%) from the detection probability of a single camera across the four species. Species that were detected infrequently benefited most from a multiple-camera array, where the addition of up to eight cameras produced significant increases in detectability. However, for species detected at high frequencies, single cameras produced a season-long (i.e, the length of time over which cameras are deployed and actively monitored) detectability greater than 0.75. These results highlight the need for researchers to be critical about camera trap study designs based on their intended target species, as detectability for each focal species responded differently to array size and season length. We suggest that researchers a priori identify

  12. Designing Fixed-Base Operations Utilizing Systems Engineering Principles

    OpenAIRE

    Stephenson, Ross L, Jr.; Carroll, David A

    2016-01-01

    There are currently over 3,200 fixed-base operations (FBOs) conducting business in the United States attempting to meet the demands of FAA Part 91, Part 135, and a limited number of Part 121 operations. With the US economy slowly climbing out of the trough during 2013, the utilization of fixed-base operations has become more attractive and economical to the corporate business and the affluent recreational traveler. Despite the increased flight activities utilizing the services of fixed-base o...

  13. Diffuse Solar System Design and Utilization in Agriculture and ...

    African Journals Online (AJOL)

    Diffuse solar radiation is a component of total solar radiation that is good for low temperature grade heating. Since the portion of the scattered radiation from the sun, which consists of short and long waves, that reaches the earth is diffused, its utilization in Agriculture as this paper suggested, has multiple phase change ...

  14. OrFPGA: An Empirical Performance Tuning Tool for FPGA Designs, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase II STTR project, RNET and its subcontractors are proposing to fully develop an empirical performance optimization tool called OrFPGA that efficiently...

  15. Wide swath imaging spectrometer utilizing a multi-modular design

    Science.gov (United States)

    Chrisp, Michael P.

    2010-10-05

    A wide swath imaging spectrometer utilizing an array of individual spectrometer modules in the telescope focal plane to provide an extended field of view. The spectrometer modules with their individual detectors are arranged so that their slits overlap with motion on the scene providing contiguous spatial coverage. The number of modules can be varied to take full advantage of the field of view available from the telescope.

  16. A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to improve patient management

    Directory of Open Access Journals (Sweden)

    Morgan John M

    2004-11-01

    Full Text Available Abstract The delivery of implantable cardioverter defibrillator (ICD therapy is sophisticated and requires the programming of over 100 settings. Physicians tailor these settings with the intention of optimizing ICD therapeutic efficacy, but the usefulness of this approach has not been studied and is unknown. Empiric programming of settings such as anti-tachycardia pacing (ATP has been demonstrated to be effective, but an empiric approach to programming all VT/VF detection and therapy settings has not been studied. A single standardized empiric programming regimen was developed based on key strategies with the intention of restricting shock delivery to circumstances when it is the only effective and appropriate therapy. The EMPIRIC trial is a worldwide, multi-center, prospective, one-to-one randomized comparison of empiric to physician tailored programming for VT/VF detection and therapy in a broad group of about 900 dual chamber ICD patients. The trial will provide a better understanding of how particular programming strategies impact the quantity of shocks delivered and facilitate optimization of complex ICD programming.

  17. Clinical Trial Designs to Support Clinical Utility of Pharmacogenomic Testing.

    Science.gov (United States)

    Drozda, Katarzyna; Pacanowski, Michael A

    2017-09-01

    Advancing the use of biomarkers and pharmacogenomics has been a key priority area for the U.S. Food and Drug Administration (FDA). The FDA offers prescribing recommendations to manage ~100 gene-drug interactions, and multiple institutions around the United States and abroad have incorporated genomic testing into patient care. However, the penetration of pharmacogenomic testing remains incomplete. In this perspective, we summarize the evidence streams to support the clinical utility of pharmacogenomic testing and its transition into clinical practice. © 2017 Pharmacotherapy Publications, Inc.

  18. Utilizing Mass Customization Methods for Modular Manufacturing System Design

    DEFF Research Database (Denmark)

    Jørgensen, Steffen; Jacobsen, Alexia; Nielsen, Kjeld

    2011-01-01

    of Mass Customization (MC). Research focus has been on the basic principles and enabling technologies, while modular architectures and system design have received less attention. A potential to fill these gaps by applying selected design theories and methods of MC have been seen. Based on a communality......Markets today have become dynamic and demand rapid product changes, product variety, and customized products. In order to operate under and taking advantages of such conditions requires, amongst other aspects, manufacturing processes robust to product changes - a contradiction to traditional...

  19. General aviation design synthesis utilizing interactive computer graphics

    Science.gov (United States)

    Galloway, T. L.; Smith, M. R.

    1976-01-01

    Interactive computer graphics is a fast growing area of computer application, due to such factors as substantial cost reductions in hardware, general availability of software, and expanded data communication networks. In addition to allowing faster and more meaningful input/output, computer graphics permits the use of data in graphic form to carry out parametric studies for configuration selection and for assessing the impact of advanced technologies on general aviation designs. The incorporation of interactive computer graphics into a NASA developed general aviation synthesis program is described, and the potential uses of the synthesis program in preliminary design are demonstrated.

  20. Empirically defining rapid response to intensive treatment to maximize prognostic utility for bulimia nervosa and purging disorder.

    Science.gov (United States)

    MacDonald, Danielle E; Trottier, Kathryn; McFarlane, Traci; Olmsted, Marion P

    2015-05-01

    Rapid response (RR) to eating disorder treatment has been reliably identified as a predictor of post-treatment and sustained remission, but its definition has varied widely. Although signal detection methods have been used to empirically define RR thresholds in outpatient settings, RR to intensive treatment has not been investigated. This study investigated the optimal definition of RR to day hospital treatment for bulimia nervosa and purging disorder. Participants were 158 patients who completed ≥6 weeks of day hospital treatment. Receiver operating characteristic (ROC) analysis was used to create four definitions of RR that could differentiate between remission and nonremission at the end of treatment. Definitions were based on binge/vomit episode frequency or percent reduction from pre-treatment, during either the first four or first two weeks of treatment. All definitions were associated with higher remission rates in rapid compared to nonrapid responders. Only one definition (i.e., ≤3 episodes in the first four weeks of treatment) predicted sustained remission (versus relapse) at 6- and 12-month follow-up. These findings provide an empirically derived definition of RR to intensive eating disorder treatment, and provide further evidence that early change is an important prognostic indicator. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Basic Design and Utilization of Instructional Television. Second Edition.

    Science.gov (United States)

    Coffelt, Kenneth; Combs, Bob

    Designed to help the user of instructional television (ITV) gain new insights and understandings in its applications, this handbook offers step-by-step guidance in applying ITV to the solution of a wide range of instructional and learning problems. The three sections of the manual cover topics related to (1) preparation, i.e., script writing, how…

  2. Method of Designing Phase-Shifting Masks Utilizing a Compactor

    Science.gov (United States)

    Ooi, Kazuko; Koyama, Kiyomi; Kiryu, Masakazu

    1994-12-01

    A new method is proposed for designing Levenson-type phase-shifting masks. In this method, phases are assigned in an intermediate layout, and then the intermediate layout is converted to a final layout. In practice, the intermediate layout is a symbolic layout, and the symbolic layout is converted to a mask layout by a compactor. According to the strategy, no conflict spots arise during the operation, which greatly improves design efficiency. This design method is applicable to random patterns in a memory peripheral circuit and in microcomputer chips. As a result of application to the peripheral circuit of dynamic random access memory (DRAM), about 16% shrinkage of the mask area was obtained, compared with a conventional mask. As for a microcomputer chip, 12% shrinkage of mask area was obtained under the condition of 50% shrinkage of aluminum-wire spacing. Together with the interactive method reported before, which is applicable to a memory core circuit, the design of the Levenson-type masks for standard LSIs is totally covered.

  3. Experimental Design: Utilizing Microsoft Mathematics in Teaching and Learning Calculus

    Science.gov (United States)

    Oktaviyanthi, Rina; Supriani, Yani

    2015-01-01

    The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, students' achievement and the effects of the use of Microsoft…

  4. Sustainable DME synthesis-design with CO2 utilization

    DEFF Research Database (Denmark)

    Prasertsri, Weeranut; Frauzem, Rebecca; Suriyapraphadilok, Uthaiporn

    2016-01-01

    : (A) dry reforming step, methanol synthesis step, and methanol dehydration step; (B) CO2 hydrogenation step followed by methanol dehydration step; and (C) dry reforming step followed by direct DME synthesis step. Starting with a base-case design, the process flow sheets for the three routes...

  5. Designing flexible engineering systems utilizing embedded architecture options

    Science.gov (United States)

    Pierce, Jeff G.

    This dissertation develops and applies an integrated framework for embedding flexibility in an engineered system architecture. Systems are constantly faced with unpredictability in the operational environment, threats from competing systems, obsolescence of technology, and general uncertainty in future system demands. Current systems engineering and risk management practices have focused almost exclusively on mitigating or preventing the negative consequences of uncertainty. This research recognizes that high uncertainty also presents an opportunity to design systems that can flexibly respond to changing requirements and capture additional value throughout the design life. There does not exist however a formalized approach to designing appropriately flexible systems. This research develops a three stage integrated flexibility framework based on the concept of architecture options embedded in the system design. Stage One defines an eight step systems engineering process to identify candidate architecture options. This process encapsulates the operational uncertainty though scenario development, traces new functional requirements to the affected design variables, and clusters the variables most sensitive to change. The resulting clusters can generate insight into the most promising regions in the architecture to embed flexibility in the form of architecture options. Stage Two develops a quantitative option valuation technique, grounded in real options theory, which is able to value embedded architecture options that exhibit variable expiration behavior. Stage Three proposes a portfolio optimization algorithm, for both discrete and continuous options, to select the optimal subset of architecture options, subject to budget and risk constraints. Finally, the feasibility, extensibility and limitations of the framework are assessed by its application to a reconnaissance satellite system development problem. Detailed technical data, performance models, and cost estimates

  6. Current hybrid-electric powertrain architectures: Applying empirical design data to life cycle assessment and whole-life cost analysis

    International Nuclear Information System (INIS)

    Hutchinson, Tim; Burgess, Stuart; Herrmann, Guido

    2014-01-01

    Highlights: • Design data for 44 hybrid cars available in the US has been gathered and analysed. • An empirical life cycle assessment of greenhouse gas emissions is performed. • Empirical whole-life cost modelling is used to evaluate powertrain architectures. • The value to be seen in each architecture is highly dependent on its application. • Mild, HSD and Plug-in HSD powertrains are the most likely architectures to dominate. - Abstract: The recent introduction of hybrid-electric powertrain technology has disrupted the automotive industry, causing significant powertrain design divergence. As this radical powertrain innovation matures, will hybrid vehicles dominate the future automotive market and does this represent a positive shift in the environmental impact of the industry? The answer to this question is sought within this paper. It seeks to take advantage of the position that the industry has reached, replacing previous theoretical studies with the first extensive empirical models of life cycle emissions and whole-life costing. A comprehensive snapshot of today’s hybrid market is presented, with detailed descriptions of the various hybrid powertrain architectures. Design data has been gathered for 44 hybrid passenger cars currently available in the US. The empirical data is used to explore the relative life cycle greenhouse gas emissions and whole-life costing of different hybrid powertrain architectures. Potential dominant designs are identified and their emissions are shown to be reduced. However, both the emissions and economic competitiveness of different hybrid powertrains are shown to vary significantly depending on how the vehicle is used

  7. Design of smart prosthetic knee utilizing magnetorheological damper

    Science.gov (United States)

    Gao, F.; Liu, Y. N.; Liao, W. H.

    2017-04-01

    In this study, based on human knee's kinetics, a smart prosthetic knee employing springs, DC motor and magnetorheological (MR) damper is designed. The MR damper is coupled in series with the springs that are mounted in parallel with the DC motor. The working principle of the prosthesis during level-ground walking is presented. During stance phase, the MR damper is powered on. The springs will store and release the negative mechanical energy for restoring the function of human knee joint. In swing phase, the MR damper is powered off for disengaging the springs. In this phase, the work of knee joint is negative. For improving the system energy efficiency, the DC motor will work as a power generator to supply required damping torque and harvest electrical energy. Finally, the design of MR damper is introduced.

  8. Gender Wage Gaps by College Major in Taiwan: Empirical Evidence from the 1997-2003 Manpower Utilization Survey

    Science.gov (United States)

    Lin, Eric S.

    2010-01-01

    In this article, we examine the effect of incorporating the fields of study on the explained and unexplained components of the standard Oaxaca decomposition for the gender wage gaps in Taiwan using 1997-2003 Manpower Utilization Survey data. Using several existing and lately developed measures, we inspect the gender wage gap by college major to…

  9. Federal and State Structures to Support Financing Utility-Scale Solar Projects and the Business Models Designed to Utilize Them

    Energy Technology Data Exchange (ETDEWEB)

    Mendelsohn, M.; Kreycik, C.

    2012-04-01

    Utility-scale solar projects have grown rapidly in number and size over the last few years, driven in part by strong renewable portfolio standards (RPS) and federal incentives designed to stimulate investment in renewable energy technologies. This report provides an overview of such policies, as well as the project financial structures they enable, based on industry literature, publicly available data, and questionnaires conducted by the National Renewable Energy Laboratory (NREL).

  10. Utility-Scale Solar 2013: An empirical analysis of project cost, performance, and pricing trends in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Weaver, Samantha [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-09-17

    Other than the SEGS I-IX parabolic trough projects built in the 1980s, virtually no large-scale or "utility-scale" solar projects-defined here to include any ground-mounted photovoltaic ("PV"), concentrating photovoltaic ("CPV"), or concentrating solar power ("CSP" or solar thermal) project larger than 5 MWAC-existed in the United States prior to 2007.

  11. Estimating Intervention Effects across Different Types of Single-Subject Experimental Designs: Empirical Illustration

    Science.gov (United States)

    Moeyaert, Mariola; Ugille, Maaike; Ferron, John M.; Onghena, Patrick; Heyvaert, Mieke; Beretvas, S. Natasha; Van den Noortgate, Wim

    2015-01-01

    The purpose of this study is to illustrate the multilevel meta-analysis of results from single-subject experimental designs of different types, including AB phase designs, multiple-baseline designs, ABAB reversal designs, and alternating treatment designs. Current methodological work on the meta-analysis of single-subject experimental designs…

  12. A new air-fuel WSGGM for better utility boiler simulation, design and optimization

    DEFF Research Database (Denmark)

    Yin, Chungen

    Radiation is the principal mode of heat transfer in utility boiler furnaces. Models for radiative properties play a vital role in reliable simulations of utility boilers and simulation-based design and optimization. The weighted sum of gray gases model (WSGGM) is one of the most widely used model...

  13. 75 FR 79982 - Authority To Designate Financial Market Utilities as Systemically Important

    Science.gov (United States)

    2010-12-21

    ... for systemic importance by the Council? 3. Which of the considerations listed in section 804(a)(2) are..., interdependencies, and other interactions of financial market utilities listed as considerations in section 804(a)(2..., financial market utilities? 10. What role should international considerations play in designating financial...

  14. High degree utilization of computers for design of nuclear power plants

    International Nuclear Information System (INIS)

    Masui, Takao; Sawada, Takashi

    1992-01-01

    Nuclear power plants are the huge technology in which various technologies are compounded, and the high safety is demanded. Therefore, in the design of nuclear power plants, it is necessary to carry out the design by sufficiently grasping the behavior of the plants, and to confirm the safety by carrying out the accurate design evaluation supposing the various operational conditions, and as the indispensable tool for these analysis and evaluation, the most advanced computers in that age have been utilized. As to the utilization for the design, there are the fields of design, analysis and evaluation and another fields of the application to the support of design. Also in the field of the application to operation control, computers are utilized. The utilization of computers for the core design, hydrothermal design, core structure design, safety analysis and structural analysis of PWR plants, and for the nuclear design, safety analysis and heat flow analysis of FBR plants, the application to the support of design and the application to operation control are explained. (K.I.)

  15. Thermal energy storage heat exchanger: Molten salt heat exchanger design for utility power plants

    Science.gov (United States)

    Ferarra, A.; Yenetchi, G.; Haslett, R.; Kosson, R.

    1977-01-01

    Sizing procedures are presented for latent heat thermal energy storage systems that can be used for electric utility off-peak energy storage, solar power plants and other preliminary design applications.

  16. Towards designing and implementing an empirically grounded research for humanitarian logistics after nepal earthquake

    NARCIS (Netherlands)

    Baharmand, Hossein; Comes, M.; Lauras, Matthieu

    2017-01-01

    Purpose This paper proposes a research design for effective use of qualitative data from field research in a quantitative analysis of humanitarian logistics. Design/methodology/approach Our research design is composed of qualitative and quantitative components. The qualitative part has four steps:

  17. Empirical Test of the Know, See, Plan, Do Model for Curriculum Design in Leadership Education

    Science.gov (United States)

    Martin, Beth Ann; Allen, Scott J.

    2016-01-01

    This research assesses the Know, See, Plan, portions of the Know, See, Plan, Do (KSPD) model for curriculum design in leadership education. There were 3 graduate student groups, each taught using 1 of 3 different curriculum designs (KSPD and 2 control groups). Based on a pretest, post-test design, students' performance was measured to assess their…

  18. Analyses of Public Utility Building - Students Designs, Aimed at their Energy Efficiency Improvement

    Science.gov (United States)

    Wołoszyn, Marek Adam

    2017-10-01

    Public utility buildings are formally, structurally and functionally complex entities. Frequently, the process of their design involves the retroactive reconsideration of energy engineering issues, once a building concept has already been completed. At that stage, minor formal corrections are made along with the design of the external layer of the building in order to satisfy applicable standards. Architecture students do the same when designing assigned public utility buildings. In order to demonstrate energy-related defects of building designs developed by students, the conduct of analyses was proposed. The completed designs of public utility buildings were examined with regard to energy efficiency of the solutions they feature through the application of the following programs: Ecotect, Vasari, and in case of simpler analyses ArchiCad program extensions were sufficient.

  19. An Empirical Assessment of Metaphor Use in the Design Studio: Analysis, Reflection and Restructuring of Architectural Design

    Science.gov (United States)

    Casakin, Hernan

    2012-01-01

    This investigation was concerned with the use of metaphors in architectural design education. Reasoning by means of metaphors helps to understand a design situation in terms of a remote concept normally not associated with it. By juxtaposing the known with the unknown in an unusual way, metaphors can enhance design problem solving. The goal of…

  20. Tax design-tax evasion relationship in Serbia: New empirical approach to standard theoretical model

    Directory of Open Access Journals (Sweden)

    Ranđelović Saša

    2015-01-01

    Full Text Available This paper provides evidence on the impact of the change in income tax rates and the degree of its progressivity on the scale of labour taxes evasion in Serbia, using the tax-benefit microsimulation model and econometric methods, on 2007 Living Standard Measurement Survey data. The empirical analysis is based on novel assumption that individual's tax evasion decision depends on a change in disposable income, which is captured by the variation in their Effective Marginal Tax Rates (EMTR, rather than on a change in after-tax income. The results suggest that the elasticity of tax evasion to EMTR equals -0.3, confirming the Yitzhaki's theory, while the propensity to evade is decreasing in the level of wages and increasing in the level of self-employment income. The results also show that introduction of revenue-neutral, progressive taxation of labour income would lead to increase in labour tax evasion by 1 percentage point.

  1. Evidence-based architectural and space design supports Magnet® empirical outcomes.

    Science.gov (United States)

    Ecoff, Laurie; Brown, Caroline E

    2010-12-01

    This department expands nursing leaders' knowledge and competencies in health facility design. The editor of this department, Dr Jaynelle Stichler, asked guest authors, Drs Ecoff and Brown, to describe the process of using the conceptual models of a nursing evidence-based practice model and the Magnet Recognition Program® as a structured process to lead decision making in the planning and design processes and to achieve desired outcomes in hospital design.

  2. OrFPGA: An Empirical Performance Tuning Tool for FPGA Designs Project

    Data.gov (United States)

    National Aeronautics and Space Administration — With the capacity and performance of FPGAs suitable for space borne applications continuously increasing, the design of FPGAs is becoming increasingly complex...

  3. Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Micek Scott T

    2010-06-01

    Full Text Available Abstract Background Candida represents the most common cause of invasive fungal disease, and candidal blood stream infections (CBSI are prevalent in the ICU. Inappropriate antifungal therapy (IAT is known to increase a patient's risk for death. We hypothesized that in an ICU cohort it would also adversely affect resource utilization. Methods We retrospectively identified all patients with candidemia on or before hospital day 14 and requiring an ICU stay at Barnes-Jewish Hospital between 2004 and 2007. Hospital length of stay following culture-proven onset of CBSI (post-CBSI HLOS was primary and hospital costs secondary endpoints. IAT was defined as treatment delay of ≥24 hours from candidemia onset or inadequate dose of antifungal agent active against the pathogen. We developed generalized linear models (GLM to assess independent impact of inappropriate therapy on LOS and costs. Results Ninety patients met inclusion criteria. IAT was frequent (88.9%. In the IAT group antifungal delay ≥24 hours occurred in 95.0% and inappropriate dosage in 26.3%. Unadjusted hospital mortality was greater among IAT (28.8% than non-IAT (0% patients, p = 0.059. Both crude post-CBSI HLOS (18.4 ± 17.0 vs. 10.7 ± 9.4, p = 0.062 and total costs ($66,584 ± $49,120 vs. $33,526 ± $27,244, p = 0.006 were higher in IAT than in non-IAT. In GLMs adjusting for confounders IAT-attributable excess post-CBSI HLOS was 7.7 days (95% CI 0.6-13.5 and attributable total costs were $13,398 (95% CI $1,060-$26,736. Conclusions IAT of CBSI, such as delays and incorrect dosing, occurs commonly. In addition to its adverse impact on clinical outcomes, IAT results in substantial prolongation of hospital LOS and increase in hospital costs. Efforts to enhance rates of appropriate therapy for candidemia may improve resource use.

  4. An Empirical Comparison of Five Linear Equating Methods for the NEAT Design

    Science.gov (United States)

    Suh, Youngsuk; Mroch, Andrew A.; Kane, Michael T.; Ripkey, Douglas R.

    2009-01-01

    In this study, a data base containing the responses of 40,000 candidates to 90 multiple-choice questions was used to mimic data sets for 50-item tests under the "nonequivalent groups with anchor test" (NEAT) design. Using these smaller data sets, we evaluated the performance of five linear equating methods for the NEAT design with five levels of…

  5. Flexibility and Control : An empirical study relating production flexibility to the design of performance management systems

    NARCIS (Netherlands)

    Van Veen-Dirks, P.M.G.

    2002-01-01

    A critical challenge facing organizations is the design of management control systems, which play a key role in evaluating the achievement of organizational and individual objectives. This thesis addresses the design of management control (performance management) systems in the current flexible

  6. New Perspective on Visual Communication Design Education: An Empirical Study of Applying Narrative Theory to Graphic Design Courses

    Science.gov (United States)

    Yang, Chao-Ming; Hsu, Tzu-Fan

    2017-01-01

    Visual communication design (VCD) is a form of nonverbal communication. The application of relevant linguistic or semiotic theories to VCD education renders graphic design an innovative and scientific discipline. In this study, actual teaching activities were examined to verify the feasibility of applying narrative theory to graphic design…

  7. Empirical approach to outdoor WBGT from meteorological data and performance of two different instrument designs.

    Science.gov (United States)

    Bernard, Thomas E; Barrow, Christina A

    2013-01-01

    The wet bulb globe temperature index (WBGT) is a common method to assess the environmental contribution to heat stress as part of an occupational exposure assessment. The two purposes of this study were (1) to compare empirical relationships of some meteorological conditions to WBGT, and (2) to evaluate a smaller globe and alternative method to assess natural wet bulb using a relative humidity sensor. Data were collected in six West-central Florida locations over multiple days for a total of 14 measurement days. Multiple linear regression was used to explore relationships relevant to the two purposes. It was clear that estimating WBGT directly from meteorological data or through estimates of the components of WBGT can be accomplished with a 95% confidence of ± 2°C-WBGT. The 50 mm globe size is a reasonable approximation of the standard size (150 mm). The relative humidity method of the waterless natural wet bulb provides a very good estimation of natural wet bulb temperature. The determination of WBGT from the electronic instruments (small globe with or without the relative humidity method) provided a good estimate of the WBGT.

  8. Utilization of MCNP code in the research and design for China advanced research reactor

    International Nuclear Information System (INIS)

    Shen Feng

    2006-01-01

    MCNP, which is the internationalized neutronics code, is used for nuclear research and design in China Advanced Research Reactor (CARR). MCNP is an important neutronics code in the research and design for CARR since many calculation tasks could be undertaken by it. Many nuclear parameters on reactor core, the design and optimization research for many reactor utilizations, much verification for other nuclear calculation code and so on are conducted with help of MCNP. (author)

  9. An investigation of the accuracy of empirical aircraft design for the development of an unmanned aerial vehicle intended for liquid hydrogen fuel

    Science.gov (United States)

    Chaney, Christopher Scott

    A study was conducted to assess the accuracy of empirical techniques used for the calculation of flight performance for unmanned aerial vehicles. This was achieved by quantifying the error between a mathematical model developed with these techniques and experimental test data taken using an unmanned aircraft. The vehicle utilized for this study was developed at Washington State University for the purpose of flying using power derived from hydrogen stored as a cryogenic liquid. The vehicle has a mass of 32.8 kg loaded and performed a total of 14 flights under battery power for 3.58 total flight hours. Over these flights, the design proved it is capable of sustaining level flight from the power available from a PEM fuel cell propulsion system. The empirical techniques used by the model are explicitly outlined within. These yield several performance metrics that are compared to measurements taken during flight testing. Calculations of required thrust for steady flight over all airspeeds and rates of climb modeled are found to have a mean percent error of 3.2%+/-7.0% and a mean absolute percent error of 34.6%+/-5.1%. Comparison of the calculated and measured takeoff distance are made and the calculated thrust required to perform a level turn at a given rate is compared to flight test data. A section of a test flight is analyzed, over which the vehicle proves it can sustain level flight under 875 watts of electrical power. The aircraft's design is presented including the wing and tail, propulsion system, and build technique. The software and equipment used for the collection and analysis of flight data are given. Documentation and validation is provided of a unique test rig for the characterization of propeller performance using a car. The aircraft remains operational to assist with research of alternative energy propulsion systems and novel fuel storage techniques. The results from the comparison of the mathematical model and flight test data can be utilized to assist

  10. Design Integration - a theroretical and empirical study of design integration in small and medium sized Danish companies

    DEFF Research Database (Denmark)

    Erichsen, Pia Geisby

    Designbegrebet har ændret sig i de seneste år fra at være associeret med møbler, produkter og grafisk design til også at omhandle nye måder at løse komplekse problemer. Derfor er mange virksomheder interesseret i at se nærmere på, hvordan design kan bidrage til udfordringer omhandlende øget innov...

  11. The adoption and design of enterprise risk management practices : An empirical study

    NARCIS (Netherlands)

    Paape, L.; Speklé, R.F.

    2010-01-01

    Using data from 825 organizations, we examine (1) the extent of ERM implementation and the factors that are associated with cross-sectional differences in the level of ERM adoption, and (2) specific ERM design choices and their effect on perceived ERM effectiveness. Broadly consistent with previous

  12. Design Principles of Worked Examples: A Review of the Empirical Studies

    Science.gov (United States)

    Shen, Chun-Yi; Tsai, Hui-Chun

    2009-01-01

    Many researchers investigated the efficacy of using worked examples in classroom instruction and provided evidence in the effectiveness of worked example instruction in mathematics, computer programming, physics, and etc. However, there are limited studies in worked example design. The purpose of this study is to generate the instructional design…

  13. The adoption and design of Enterprise Risk Management practices : An empirical study

    NARCIS (Netherlands)

    Paape, L.; Speklé, R.F.

    2012-01-01

    We examine (1) the extent of enterprise risk management (ERM) implementation and the factors that are associated with cross-sectional differences in the level of ERM adoption, and (2) specific risk management design choices and their effect on perceived risk management effectiveness. Broadly

  14. Taking Word Clouds Apart: An Empirical Investigation of the Design Space for Keyword Summaries.

    Science.gov (United States)

    Felix, Cristian; Franconeri, Steven; Bertini, Enrico

    2018-01-01

    In this paper we present a set of four user studies aimed at exploring the visual design space of what we call keyword summaries: lists of words with associated quantitative values used to help people derive an intuition of what information a given document collection (or part of it) may contain. We seek to systematically study how different visual representations may affect people's performance in extracting information out of keyword summaries. To this purpose, we first create a design space of possible visual representations and compare the possible solutions in this design space through a variety of representative tasks and performance metrics. Other researchers have, in the past, studied some aspects of effectiveness with word clouds, however, the existing literature is somewhat scattered and do not seem to address the problem in a sufficiently systematic and holistic manner. The results of our studies showed a strong dependency on the tasks users are performing. In this paper we present details of our methodology, the results, as well as, guidelines on how to design effective keyword summaries based in our discoveries.

  15. An online corpus of UML Design Models : construction and empirical studies

    NARCIS (Netherlands)

    Karasneh, B.H.A.

    2016-01-01

    We address two problems in Software Engineering. The first problem is how to assess the severity of software defects? The second problem we address is that of studying software designs. Automated support for assessing the severity of software defects helps human developers to perform this task more

  16. The social structure of leadership and creativity in engineering design teams : An empirical analysis

    NARCIS (Netherlands)

    Kratzer, Jan; Leenders, Roger Th. A. J.; Van Engelen, Jo M. L.

    2008-01-01

    Creativity is essential for research and development efforts. Unfortunately, little is known about how the role of team leaders determines the team's creativity. Based on a sample of 39 engineering design teams in the space industry, this study examines the effects of leader position within

  17. Design criteria for the light duty utility arm system end effectors

    International Nuclear Information System (INIS)

    Pardini, A.F.; Kiebel, G.R.

    1995-12-01

    The purpose of this document is to provide criteria for the design of end effectors that will be used as part of the Light Duty Utility Arm (LDUA) System. Actual component design, fabrication, testing, and inspection will be performed by various DOE laboratories, industry, and academia. This document augments WHC-SD-TD-FRD-003, 'Functions and Requirements for the Light Duty Utility Arm Integrated System' (F). All requirements dictated in the F shall also be applicable in this document. Whenever conflicts arise between this document and the F, this document shall take precedence

  18. A Method for Sustainable Carbon Dioxide Utilization Process Synthesis and Design

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Fjellerup, Kasper; Roh, Kosan

    for the process synthesis, design and more sustainable design. Using a superstructure-based approach a network of utilization alternatives is created linking CO2 and other raw materials with various products using processing blocks. This will then be optimized and verified for sustainability. Detailed design has...... also been performed for various case studies. These case studies include multiple pathways for the production of methanol and the production of dimethyl carbonate (DMC). From detailed design and analysis, CO2 conversion processes show promise as an additional method for the sustainable reduction of CO2...

  19. Tunnel support design by comparison of empirical and finite element analysis of the Nahakki tunnel in mohmand agency, pakistan

    Directory of Open Access Journals (Sweden)

    Riaz Asif

    2016-03-01

    Full Text Available The paper analyses the geological conditions of study area, rock mass strength parameters with suitable support structure propositions for the under construction Nahakki tunnel in Mohmand Agency. Geology of study area varies from mica schist to graphitic marble/phyllite to schist. The tunnel ground is classified and divided by the empisical classification systems like Rock mass rating (RMR, Q system (Q, and Geological strength index (GSI. Tunnel support measures are selected based on RMR and Q classification systems. Computer based finite element analysis (FEM has given yet another dimension to design approach. FEM software Phase2 version 7.017 is used to calculate and compare deformations and stress concentrations around the tunnel, analyze interaction of support systems with excavated rock masses and verify and check the validity of empirically determined excavation and support systems.

  20. Utilization of Service Design in Tourism : Mobile Ethnographic Research in a Ski Resort

    OpenAIRE

    Leinonen, Mikko

    2012-01-01

    Savonia University of Applied Sciences attended as a partner on an international Service Design in Tourism co-operation pilot project, where the functionality, utilization and efficiency of the service design was simultaneously tested in seven different nations in order to enhance and to develop travel services. MyServiceFellow mobile ethnographic research was conducted between the dates of 27.12.2011 and 11.3.2012 in Tahko tourism resort, located in Central Finland. The central aim of...

  1. Designing usable web forms- Empirical evaluation of web form improvement guidelines

    DEFF Research Database (Denmark)

    Seckler, Mirjam; Heinz, Silvia; Bargas-Avila, Javier A.

    2014-01-01

    This study reports a controlled eye tracking experiment (N = 65) that shows the combined effectiveness of 20 guidelines to improve interactive online forms when applied to forms found on real company websites. Results indicate that improved web forms lead to faster completion times, fewer form su...... submission trials, and fewer eye movements. Data from subjective questionnaires and interviews further show increased user satisfaction. Overall, our findings highlight the importance for web designers to improve their web forms using UX guidelines.......This study reports a controlled eye tracking experiment (N = 65) that shows the combined effectiveness of 20 guidelines to improve interactive online forms when applied to forms found on real company websites. Results indicate that improved web forms lead to faster completion times, fewer form...

  2. TEST DESIGN FOR ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) OF ADD-ON NOX CONTROL UTILIZING OZONE INJECTION

    Science.gov (United States)

    The paper discusses the test design for environmental technology verification (ETV) of add-0n nitrogen oxides (NOx) control utilizing ozone injection. (NOTE: ETV is an EPA-established program to enhance domestic and international market acceptance of new or improved commercially...

  3. Public Utility Regulatory Policies Act of 1978: Natural Gas Rate Design Study

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-05-01

    First, the comments on May 3, 1979 Notice of Inquiry of DOE relating to the Gas Utility Rate Design Study Required by Section 306 of PURPA are presented. Then, comments on the following are included: (1) ICF Gas Utility Model, Gas Utility Model Data Outputs, Scenario Design; (2) Interim Model Development Report with Example Case Illustrations; (3) Interim Report on Simulation of Seven Rate Forms; (4) Methodology for Assessing the Impacts of Alternative Rate Designs on Industrial Energy Use; (5) Simulation of Marginal-Cost-Based Natural Gas Rates; and (6) Preliminary Discussion Draft of the Gas Rate Design Study. Among the most frequent comments expressed were the following: (a) the public should be given the opportunity to review the final report prior to its submission to Congress; (b) results based on a single computer model of only four hypothetical utility situations cannot be used for policy-making purposes for individual companies or the entire gas industry; (c) there has been an unobjective treatment of traditional and economic cost rate structures; the practical difficulties and potential detrimental consequences of economic cost rates are not fully disclosed; and (d) it is erroneous to assume that end users, particularly residential customers, are influenced by price signals in the rate structure, as opposed to the total bill.

  4. Utilizing Uncertainty Multidisciplinary Design Optimization for Conceptual Design of Space Systems

    NARCIS (Netherlands)

    Yao, W.; Guo, J.; Chen, X.; Van Tooren, M.

    2010-01-01

    With progress of space technology and increase of space mission demand, requirements for robustness and reliability of space systems are ever-increasing. For the whole space mission life cycle, the most important decisions are made in the conceptual design phase, so it is very crucial to take

  5. Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies

    Science.gov (United States)

    Page, Matthew J.; Higgins, Julian P. T.; Clayton, Gemma; Sterne, Jonathan A. C.; Hróbjartsson, Asbjørn; Savović, Jelena

    2016-01-01

    Objective To synthesise evidence on the average bias and heterogeneity associated with reported methodological features of randomized trials. Design Systematic review of meta-epidemiological studies. Methods We retrieved eligible studies included in a recent AHRQ-EPC review on this topic (latest search September 2012), and searched Ovid MEDLINE and Ovid EMBASE for studies indexed from Jan 2012-May 2015. Data were extracted by one author and verified by another. We combined estimates of average bias (e.g. ratio of odds ratios (ROR) or difference in standardised mean differences (dSMD)) in meta-analyses using the random-effects model. Analyses were stratified by type of outcome (“mortality” versus “other objective” versus “subjective”). Direction of effect was standardised so that ROR ROR 0.93, 95% CI 0.86 to 0.99; 7 studies) and allocation concealment (ROR 0.90, 95% CI 0.84 to 0.97; 7 studies). For these characteristics, the average bias appeared to be larger in trials of subjective outcomes compared with other objective outcomes. Also, intervention effects for subjective outcomes appear to be exaggerated in trials with lack of/unclear blinding of participants (versus blinding) (dSMD -0.37, 95% CI -0.77 to 0.04; 2 studies), lack of/unclear blinding of outcome assessors (ROR 0.64, 95% CI 0.43 to 0.96; 1 study) and lack of/unclear double blinding (ROR 0.77, 95% CI 0.61 to 0.93; 1 study). The influence of other characteristics (e.g. unblinded trial personnel, attrition) is unclear. Conclusions Certain characteristics of randomized trials may exaggerate intervention effect estimates. The average bias appears to be greatest in trials of subjective outcomes. More research on several characteristics, particularly attrition and selective reporting, is needed. PMID:27398997

  6. Advanced reactor design study. Assessing nonbackfittable concepts for improving uranium utilization in light water reactors

    International Nuclear Information System (INIS)

    Fleischman, R.M.; Goldsmith, S.; Newman, D.F.; Trapp, T.J.; Spinrad, B.I.

    1981-09-01

    The objective of the Advanced Reactor Design Study (ARDS) is to identify and evaluate nonbackfittable concepts for improving uranium utilization in light water reactors (LWRs). The results of this study provide a basis for selecting and demonstrating specific nonbackfittable concepts that have good potential for implementation. Lead responsibility for managing the study was assigned to the Pacific Northwest Laboratory (PNL). Nonbackfittable concepts for improving uranium utilization in LWRs on the once-through fuel cycle were selected separately for PWRs and BWRs due to basic differences in the way specific concepts apply to those plants. Nonbackfittable concepts are those that are too costly to incorporate in existing plants, and thus, could only be economically incorporated in new reactor designs or plants in very early stages of construction. Essential results of the Advanced Reactor Design Study are summarized

  7. Electric utility engineer`s FGD manual -- Volume 1: FGD process design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-04

    Part 1 of the Electric Utility Engineer`s Flue Gas Desulfurization (FGD) Manual emphasizes the chemical and physical processes that form the basis for design and operation of lime- and limestone-based FGD systems applied to coal- or oil-fired steam electric generating stations. The objectives of Part 1 are: to provide a description of the chemical and physical design basis for lime- and limestone-based wet FGD systems; to identify and discuss the various process design parameters and process options that must be considered in developing a specification for a new FGD system; and to provide utility engineers with process knowledge useful for operating and optimizing a lime- or limestone-based wet FGD system.

  8. Plant-Scale Concentration Column Designs for SHINE Target Solution Utilizing AG 1 Anion Exchange Resin

    Energy Technology Data Exchange (ETDEWEB)

    Stepinski, Dominique C. [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, G. F. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    Argonne is assisting SHINE Medical Technologies (SHINE) in their efforts to develop SHINE, an accelerator-driven process that will utilize a uranyl-sulfate solution for the production of fission product Mo-99. An integral part of the process is the development of a column for the separation and recovery of Mo-99, followed by a concentration column to reduce the product volume from 15-25 L to <1 L. Argonne has collected data from batch studies and breakthrough column experiments to utilize the VERSE (Versatile Reaction Separation) simulation program (Purdue University) to design plant-scale product recovery and concentration processes.

  9. Health insurance benefit design and healthcare utilization in northern rural China.

    Directory of Open Access Journals (Sweden)

    Hong Wang

    Full Text Available BACKGROUND: Poverty due to illness has become a substantial social problem in rural China since the collapse of the rural Cooperative Medical System in the early 1980s. Although the Chinese government introduced the New Rural Cooperative Medical Schemes (NRCMS in 2003, the associations between different health insurance benefit package designs and healthcare utilization remain largely unknown. Accordingly, we sought to examine the impact of health insurance benefit design on health care utilization. METHODS AND FINDINGS: We conducted a cross-sectional study using data from a household survey of 15,698 members of 4,209 randomly-selected households in 7 provinces, which were representative of the provinces along the north side of the Yellow River. Interviews were conducted face-to-face and in Mandarin. Our analytic sample included 9,762 respondents from 2,642 households. In each household, respondents indicated the type of health insurance benefit that the household had (coverage for inpatient care only or coverage for both inpatient and outpatient care and the number of outpatient visits in the 30 days preceding the interview and the number of hospitalizations in the 365 days preceding the household interview. People who had both outpatient and inpatient coverage compared with inpatient coverage only had significantly more village-level outpatient visits, township-level outpatient visits, and total outpatient visits. Furthermore, the increased utilization of township and village-level outpatient care was experienced disproportionately by people who were poorer, whereas the increased inpatient utilization overall and at the county level was experienced disproportionately by people who were richer. CONCLUSION: The evidence from this study indicates that the design of health insurance benefits is an important policy tool that can affect the health services utilization and socioeconomic equity in service use at different levels. Without careful

  10. Utilizing integrated facility design to improve the quality of a pediatric ambulatory surgery center.

    Science.gov (United States)

    Pelly, Nicole; Zeallear, Brian; Reed, Mark; Martin, Lynn

    2013-07-01

    The aim was to use Integrated Facility Design (IFD) to design a surgery center that enhances the delivery of health care by developing processes that provide highly efficient patient, family, and provider flows while adding value and utilizing costly resources effectively. Integrated Facility Design is an adaptation of the Toyota 3P (Production, Preparation, Process) Program. The goal of IFD is to accelerate development time and lower start-up costs. The use of IFD produced a savings of $30 million in project costs and enabled a completion date 3.5 months ahead of schedule. The designed patient flow processes resulted in dramatic improvements in patient, family, and provider throughput. The use of IFD in the design of a pediatric ambulatory clinic and surgery resulted in significant cost savings and improved clinical efficiency. © 2013 John Wiley & Sons Ltd.

  11. On the utility of within-participant research design when working with patients with neurocognitive disorders.

    Science.gov (United States)

    Steingrimsdottir, Hanna Steinunn; Arntzen, Erik

    2015-01-01

    Within-participant research designs are frequently used within the field of behavior analysis to document changes in behavior before, during, and after treatment. The purpose of the present article is to show the utility of within-participant research designs when working with older adults with neurocognitive disorders. The reason for advocating for these types of experimental designs is that they provide valid information about whether the changes that are observed in the dependent variable are caused by manipulations of the independent variable, or whether the change may be due to other variables. We provide examples from published papers where within-participant research design has been used with patients with neurocognitive disorders. The examples vary somewhat, demonstrating possible applications. It is our suggestion that the within-participant research design may be used more often with the targeted client group than is documented in the literature at the current date.

  12. Utilization of design data on conventional system to building information modeling (BIM)

    Science.gov (United States)

    Akbar, Boyke M.; Z. R., Dewi Larasati

    2017-11-01

    Nowadays infrastructure development becomes one of the main priorities in the developed country such as Indonesia. The use of conventional design system is considered no longer effectively support the infrastructure projects, especially for the high complexity building design, due to its fragmented system issues. BIM comes as one of the solutions in managing projects in an integrated manner. Despite of the all known BIM benefits, there are some obstacles on the migration process to BIM. The two main of the obstacles are; the BIM implementation unpreparedness of some project parties and a concerns to leave behind the existing database and create a new one on the BIM system. This paper discusses the utilization probabilities of the existing CAD data from the conventional design system for BIM system. The existing conventional CAD data's and BIM design system output was studied to examine compatibility issues between two subject and followed by an utilization scheme-strategy probabilities. The goal of this study is to add project parties' eagerness in migrating to BIM by maximizing the existing data utilization and hopefully could also increase BIM based project workflow quality.

  13. Design aspects of LTE desalination plant utilizing waste heat from nuclear research reactor

    International Nuclear Information System (INIS)

    Rao, I.S.; Srivastava, V.K.; Tewari, P.K.

    2004-01-01

    Nuclear research reactors produce significant amount of low quality waste heat which can be utilized for producing high quality water from seawater by coupling a Low Temperature Evaporation (LTE) desalination unit. Salient features and design considerations of the desalination plant coupled to the nuclear research reactor and the performance of the desalination plant under varying operational conditions applicable to waste heat utilization from the reactor are discussed. Chemical and radioactive analysis of the product water is given to indicate the usefulness of the water to meet the demineralized water makeup requirements of the reactor. The general scheme of integrating desalination plant with the nuclear research reactor is also presented. This LTE desalination plant utilizing waste heat from a nuclear research reactor is the first of its kind and is a demonstration of safety and economics of nuclear desalination technology as a viable alternative to produce demineralised water from seawater. (author)

  14. Design principles for CANDU control centres in response to evolving utility business needs

    International Nuclear Information System (INIS)

    Davey, E.

    2002-01-01

    Nuclear generation operators are facing a challenging business environment at the beginning of the new millennium. Evolving changes in business context, competitive commercial pressures, and changes in technology have dictated recurring evaluation of operational practices and the adequacy of supporting tools, and the pursuit of opportunities for operational improvement. A key area of utility operations that has been impacted by these changes is the nuclear plant control centre. Changes to workspace layout, equipment provisions, staffing, and work organization are examples of some of the adjustments being introduced to improve operational and safety effectiveness. This paper discusses some of the key factors influencing these changes and identifies additional design principles for CANDU control centres that will enable new control centre designs and retrofits of existing control centres to remain relevant and responsive to utility needs. (author)

  15. Utility of Army Design Methodology in U.S. Coast Guard Counter Narcotic Interdiction Strategy

    Science.gov (United States)

    2017-06-09

    of the effectiveness of the current USCG strategy (approach) to maritime interdiction through personal experience, analysis of factual data , and an...UTILITY OF ARMY DESIGN METHODOLOGY IN U.S. COAST GUARD COUNTER NARCOTIC INTERDICTION STRATEGY A thesis presented to the... SCIENCE General Studies by JOHN B. MCWHITE, LIEUTENANT COMMANDER, U.S. COAST GUARD B.S., U.S. Coast Guard Academy, New London

  16. An Integrated Design Approach for Evaluating the Utility and Cost of a Fleet

    Science.gov (United States)

    2015-04-29

    goods to a large customer base across the country, or a military fleet in a hostile environment, it is a challenge to define and evaluate the utility...Ceder [6] addressed aspects of the fleet design problem. Ceder applied simulation modeling to evaluate the effect of integrating a smart shuttle ...those for administering disaster relief after a natural disaster . Each function is evaluated using vehicle specific simulation models to determine the

  17. Simulation-Optimization Framework for Synthesis and Design of Natural Gas Downstream Utilization Networks

    Directory of Open Access Journals (Sweden)

    Saad A. Al-Sobhi

    2018-02-01

    Full Text Available Many potential diversification and conversion options are available for utilization of natural gas resources, and several design configurations and technology choices exist for conversion of natural gas to value-added products. Therefore, a detailed mathematical model is desirable for selection of optimal configuration and operating mode among the various options available. In this study, we present a simulation-optimization framework for the optimal selection of economic and environmentally sustainable pathways for natural gas downstream utilization networks by optimizing process design and operational decisions. The main processes (e.g., LNG, GTL, and methanol production, along with different design alternatives in terms of flow-sheeting for each main processing unit (namely syngas preparation, liquefaction, N2 rejection, hydrogen, FT synthesis, methanol synthesis, FT upgrade, and methanol upgrade units, are used for superstructure development. These processes are simulated using ASPEN Plus V7.3 to determine the yields of different processing units under various operating modes. The model has been applied to maximize total profit of the natural gas utilization system with penalties for environmental impact, represented by CO2eq emission obtained using ASPEN Plus for each flowsheet configuration and operating mode options. The performance of the proposed modeling framework is demonstrated using a case study.

  18. A robust rotorcraft flight control system design methodology utilizing quantitative feedback theory

    Science.gov (United States)

    Gorder, Peter James

    1993-01-01

    Rotorcraft flight control systems present design challenges which often exceed those associated with fixed-wing aircraft. First, large variations in the response characteristics of the rotorcraft result from the wide range of airspeeds of typical operation (hover to over 100 kts). Second, the assumption of vehicle rigidity often employed in the design of fixed-wing flight control systems is rarely justified in rotorcraft where rotor degrees of freedom can have a significant impact on the system performance and stability. This research was intended to develop a methodology for the design of robust rotorcraft flight control systems. Quantitative Feedback Theory (QFT) was chosen as the basis for the investigation. Quantitative Feedback Theory is a technique which accounts for variability in the dynamic response of the controlled element in the design robust control systems. It was developed to address a Multiple-Input Single-Output (MISO) design problem, and utilizes two degrees of freedom to satisfy the design criteria. Two techniques were examined for extending the QFT MISO technique to the design of a Multiple-Input-Multiple-Output (MIMO) flight control system (FCS) for a UH-60 Black Hawk Helicopter. In the first, a set of MISO systems, mathematically equivalent to the MIMO system, was determined. QFT was applied to each member of the set simultaneously. In the second, the same set of equivalent MISO systems were analyzed sequentially, with closed loop response information from each loop utilized in subsequent MISO designs. The results of each technique were compared, and the advantages of the second, termed Sequential Loop Closure, were clearly evident.

  19. Time-Resolved Nucleic Acid Hybridization Beacons Utilizing Unimolecular and Toehold-Mediated Strand Displacement Designs.

    Science.gov (United States)

    Massey, Melissa; Ancona, Mario G; Medintz, Igor L; Algar, W Russ

    2015-12-01

    Nucleic acid hybridization probes are sought after for numerous assay and imaging applications. These probes are often limited by the properties of fluorescent dyes, prompting the development of new probes where dyes are paired with novel or nontraditional luminescent materials. Luminescent terbium complexes are an example of such a material, and these complexes offer several unique spectroscopic advantages. Here, we demonstrate two nonstem-loop designs for light-up nucleic acid hybridization beacons that utilize time-resolved Förster resonance energy transfer (TR-FRET) between a luminescent Lumi4-Tb cryptate (Tb) donor and a fluorescent reporter dye, where time-resolved emission from the dye provides an analytical signal. Both designs are based on probe oligonucleotides that are labeled at their opposite termini with Tb and a fluorescent reporter dye. In one design, a probe is partially blocked with a quencher dye-labeled oligonucleotide, and target hybridization is signaled through toehold-mediated strand displacement and loss of a competitive FRET pathway. In the other design, the intrinsic folding properties of an unblocked probe are utilized in combination with a temporal mechanism for signaling target hybridization. This temporal mechanism is based on a recently elucidated "sweet spot" for TR-FRET measurements and exploits distance control over FRET efficiencies to shift the Tb lifetime within or outside the time-gated detection window for measurements. Both the blocked and unblocked beacons offer nanomolar (femtomole) detection limits, response times on the order of minutes, multiplexing through the use of different reporter dyes, and detection in complex matrices such as serum and blood. The blocked beacons offer better mismatch selectivity, whereas the unblocked beacons are simpler in design. The temporal mechanism of signaling utilized with the unblocked beacons also plays a significant role with the blocked beacons and represents a new and effective

  20. Design considerations to improve cognitive ergonomic issues of unmanned vehicle interfaces utilizing video game controllers.

    Science.gov (United States)

    Oppold, P; Rupp, M; Mouloua, M; Hancock, P A; Martin, J

    2012-01-01

    Unmanned (UAVs, UCAVs, and UGVs) systems still have major human factors and ergonomic challenges related to the effective design of their control interface systems, crucial to their efficient operation, maintenance, and safety. Unmanned system interfaces with a human centered approach promote intuitive interfaces that are easier to learn, and reduce human errors and other cognitive ergonomic issues with interface design. Automation has shifted workload from physical to cognitive, thus control interfaces for unmanned systems need to reduce mental workload on the operators and facilitate the interaction between vehicle and operator. Two-handed video game controllers provide wide usability within the overall population, prior exposure for new operators, and a variety of interface complexity levels to match the complexity level of the task and reduce cognitive load. This paper categorizes and provides taxonomy for 121 haptic interfaces from the entertainment industry that can be utilized as control interfaces for unmanned systems. Five categories of controllers were based on the complexity of the buttons, control pads, joysticks, and switches on the controller. This allows the selection of the level of complexity needed for a specific task without creating an entirely new design or utilizing an overly complex design.

  1. The design and utility of institutional teaching awards: a literature review.

    Science.gov (United States)

    Huggett, Kathryn N; Greenberg, Ruth B; Rao, Deepa; Richards, Boyd; Chauvin, Sheila W; Fulton, Tracy B; Kalishman, Summers; Littlefield, John; Perkowski, Linda; Robins, Lynne; Simpson, Deborah

    2012-01-01

    Institutional teaching awards have been used widely in higher education since the 1970s. Nevertheless, a comprehensive review of the literature on such awards has not been published since 1997. We conducted a literature review to learn as much as possible about the design (e.g., formats, selection processes) and utility (e.g., impact on individuals and institutions) of teaching awards in order to provide information for use in designing, implementing, or evaluating award programs. We searched electronic databases for English-language publications on awards for exemplary teaching. Targeted publications included descriptions and/or investigations of award programs, their impact, and theoretical or conceptual models for awards programs. Screening was conducted by dual review; a third reviewer was assigned for disagreements. Data were analyzed qualitatively. Results were summarized descriptively. We identified 1302 publications for initial relevancy screening by title and abstract. We identified an additional 23 publications in a follow-up search. The full text of 126 publications was reviewed for further relevance. A total of 62 publications were identified as relevant, and of these 43 met our criteria for inclusion. Of the 43, 19 described the design features of 24 awards; 20 reports discussed award utility. Nomination and selection processes and benefits (e.g., plaques) varied as did perceived impact on individuals and institutions. Limited evidence exists regarding design and utility of teaching awards. Awards are perceived as having potential for positive impact, including promotions, but may also have unintended negative consequences. Future research should investigate the impact of awards on personal and professional development, and how promotion and tenure committees perceive awards.

  2. Improving fuel utilization in SmAHTR with spectral shift control design: Proof of concept

    International Nuclear Information System (INIS)

    Kotlyar, D.; Lindley, B.A.; Mohamed, H.

    2017-01-01

    Highlights: • Improving the fuel utilization in a graphite moderated reactor by adopting the ‘spectral shift’ concept. • The feasibility of this concept was tested in the Small Advanced High-Temperature Reactor. • At BOL, the reactor is under-moderated, with excess neutrons being primarily breeding 239 Pu. • Graphite is continuously inserted thermalizing the neutron spectrum and increasing reactivity. • The extra 239 Pu bred during the cycle is then burned, allowing the cycle to be extended. - Abstract: This paper presents a spectral shift design based approach to improve the fuel utilization factor or alternatively to increase the cycle length in a graphite moderated reactor. The feasibility of this concept was tested in the Small Advanced High-Temperature Reactor (SmAHTR). This is a small sized Fluoride-salt-cooled high-temperature reactor (FHR) that uses tri-isotropic (TRISO)-coated particle fuels and graphite moderator materials. A major benefit of the TRISO particles is the ability to mitigate fission product release in the case of an accident. However, the fabrication costs associated with TRISO particles are expected to be significantly higher than the traditional UO 2 fuel. The preliminary studies presented in the paper are focused on extending the achievable irradiation period without increasing the value of the enrichment. In order to increase the discharge burnup, the design includes graphite structures that are initially removed from the core. This imposes a harder spectrum, which enhances the breeding of 239 Pu. Then, the graphite structures are gradually and continuously inserted into the core to sustain criticality. This procedure shifts the hard spectrum into a more thermal one and enables a more efficient utilization of 239 Pu. The preliminary results indicate that this design achieves considerably longer irradiation periods and hence lower fuel cycle costs than the reference design.

  3. Design considerations for honeycomb double-bubble tanks utilized in aerospace vehicles

    Science.gov (United States)

    Lentz, Christopher A.; Bush, Lance B.

    1990-01-01

    Future earth-to-orbit vehicles will utilize reusable internal fuel tanks requiring most of the vehicle volume. Because weight reduction and volumetric efficiency are essential, these tanks will be integral to the vehicle structure, and the vehicle cross section will dictate the size and shape of the tank. For a fuselage with a noncircular cross section, a multibubble tank configuration may be employed. Multibubble tanks offer a reduction in tank weight over a single-lobe tank or several cylindrical tanks in a noncircular cross section but sacrifice the efficiency of utilizing the entire fuselage cross section. This paper includes a general configuration analysis of a double-bubble tank, a materials and efficiency study, and a complete mission design analysis centers on sizing the tank to withstand ascent and reentry loads while minimizing the structural weight.

  4. Design program to increase the EDG rated load at Gulf States Utilities - River Bend Station

    International Nuclear Information System (INIS)

    Pischinger, F.; Rogers, G.; Last, R.

    1987-01-01

    This paper presents the results of a program to develop system design improvements which, if incorporated, would increase the EDG rated loads at Gulf States Utilities (GSU) River Bend Station (RBS) - unit 1. The Transamerica Delaval Inc. (TDI) DSR-48 diesel generators are currently restricted to 3130 kW while the name plate rating is 3500 kW, continuous, and 3850 kW for intermittent overload conditions. The project focused on the design margin of the diesel engine crankshaft and evaluated alternative modifications including: reduction of the EDG system excitation; reduction of crankshaft stresses through geometrical changes; and increased material strength. Upon completing an assessment of the engine operational characteristics and evaluating the existing crankshaft design, improved crankshaft design, material and fabrication specifications were developed. These changes include modifications to the crank web fillet geometries and oil hole radii. However, no changes are necessary for the existing block, connecting rods, bearings or generator. The design calculated safety factor is 1.269 at 3500 kW, when using the conservative criteria described by Kritzer and Stahl which is commonly used by German engine manufacturers. A factor of 1.25 is considered adequate when applying these conservative design criteria. All of these proposed changes, in combination, provide an adequate operational safety factor at 3500 kW, 450 rpm, with intermittent overload to 3850 kW. (orig.)

  5. Expanding the printable design space for lithography processes utilizing a cut mask

    Science.gov (United States)

    Wandell, Jerome; Salama, Mohamed; Wilkinson, William; Curtice, Mark; Feng, Jui-Hsuan; Gao, Shao Wen; Asthana, Abhishek

    2016-03-01

    The utilization of a cut-mask in semiconductor patterning processes has been in practice for logic devices since the inception of 32nm-node devices, notably with unidirectional gate level printing. However, the microprocessor applications where cut-mask patterning methods are used are expanding as Self-Aligned Double Patterning (SADP) processes become mainstream for 22/14nm fin diffusion, and sub-14nm metal levels. One common weakness for these types of lithography processes is that the initial pattern requiring the follow-up cut-mask typically uses an extreme off-axis imaging source such as dipole to enhance the resolution and line-width roughness (LWR) for critical dense patterns. This source condition suffers from poor process margin in the semi-dense (forbidden pitch) realm and wrong-way directional design spaces. Common pattern failures in these limited design regions include bridging and extra-printing defects that are difficult to resolve with traditional mask improvement means. This forces the device maker to limit the allowable geometries that a designer may use on a device layer. This paper will demonstrate methods to expand the usable design space on dipole-like processes such as unidirectional gate and SADP processes by utilizing the follow-up cut mask to improve the process window. Traditional mask enhancement means for improving the process window in this design realm will be compared to this new cut-mask approach. The unique advantages and disadvantages of the cut-mask solution will be discussed in contrast to those customary methods.

  6. Design criteria for the light duty utility arm system end effectors

    International Nuclear Information System (INIS)

    Pardini, A.F.

    1995-01-01

    This document provides the criteria for the design of end effectors that will be used as part of the Light Duty Utility Arm (LDUA) System. The LDUA System consists of a deployment vehicle, a vertical positioning mast, a light duty multi-axis robotic arm, a tank riser interface and confinement, a tool interface plate, a control system, and an operations control trailer. The criteria specified in this document will apply to all end effector systems being developed for use on or with the LDUA system at the Hanford site. The requirement stipulated in this document are mandatory

  7. Design of a miniature SWIR hyperspectral snapshot imager utilizing multivariate optical elements

    Science.gov (United States)

    Priore, Ryan; Dougherty, John; Cohen, Omer; Bikov, Leonid; Hirsh, Itay

    2016-10-01

    CIRTEMO, SCD and Pixelteq have co-developed a miniature short-wave infrared (SWIR) hyperspectral snapshot imager utilizing Multivariate Optical Elements (MOEs). The resultant product may address many of the detection challenges facing multiple markets including commercial, medical, security and defense. This paper highlights the design process of developing MOEs for a targeted application, as well as the technological challenges faced and solutions developed for successful integration of a micro-patterned mosaic array to an InGaAs focal plane array.

  8. Electric Utility Rate Design Study: comments on two costing approaches for time-differentiated rates

    Energy Technology Data Exchange (ETDEWEB)

    Ashburn, R.E.

    1977-03-08

    A critique of consultants' reports on Topic 4 (Costing for Peak-Load Pricing) of EEI/EPRI Electric Utility Rate Design Study is presented. Correlated areas of Topic 1.3 are identified. The first critique is of NERA's August 15, 1976 Draft Report on How to Quantify Marginal Costs. The second critique is of Ebasco Services, Inc., September 8, 1976 Draft Report on Costing for Peak-Load Pricing. References made to Topic 1.3 refer to the September 15, 1976 Ebasco draft of Topic 1.3. (MCW)

  9. Utility FGD Survey, January--December 1989. Volume 2, Design performance data for operating FGD systems, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. [IT Corp., Cincinnati, OH (United States)

    1992-03-01

    The Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. The development status (operational, under construction, or in the planning stages), system supplier, process, waste disposal practice, and regulatory class are tabulated alphabetically by utility company.

  10. Design and fabrication of light-guiding plate for a photobioreactor that utilizes sunlight

    Science.gov (United States)

    Lim, Hyon-Chol; Kim, Hun; Jang, Kyungmin; Kim, Jae-Young; Baek, Joon-Hyuck; Yang, Seung-Jin; Jeong, Sang-Hwa; Park, Jong-Rak

    2015-10-01

    We present the results of the optical design and fabrication of a light-guiding plate (LGP) that utilizes sunlight to be adopted as an illumination system for photobioreactors. A solar daylighting system was employed as the light source for the LGP. We modeled the light sources (optical fiber exit ports of the solar daylighting system), a reflection film, and LGP patterns. An LGP (1000 mm × 500 mm × 10 mm) was designed and fabricated using a computerized numerical control machine. It was optimized for the average deviation of the illuminance distribution by varying the maximum pattern spacing, minimum pattern spacing, and spacing constant of the pattern spacing function expressed in the form of an exponential function. Average illuminance and uniformity of the illuminance distribution of the fabricated LGP were measured to be 8174 lx (photon flux density: 122.0 μΕ m-2 s-1) and 90.0 %, respectively.

  11. Utilization of building information modeling in infrastructure’s design and construction

    Science.gov (United States)

    Zak, Josef; Macadam, Helen

    2017-09-01

    Building Information Modeling (BIM) is a concept that has gained its place in the design, construction and maintenance of buildings in Czech Republic during recent years. This paper deals with description of usage, applications and potential benefits and disadvantages connected with implementation of BIM principles in the preparation and construction of infrastructure projects. Part of the paper describes the status of BIM implementation in Czech Republic, and there is a review of several virtual design and construction practices in Czech Republic. Examples of best practice are presented from current infrastructure projects. The paper further summarizes experiences with new technologies gained from the application of BIM related workflows. The focus is on the BIM model utilization for the machine control systems on site, quality assurance, quality management and construction management.

  12. European utility requirements: common rules to design next LWR plants in an open electricity market

    International Nuclear Information System (INIS)

    Berbey, Pierre; Ingemarsson, Karl-Fredrik

    2004-01-01

    The major European electricity producers want to keep able to build new nuclear power plants and they believe 3. generation LWRs would be the most adapted response to their needs in the first decades of this century. Producing a common European Utility Requirement (EUR) document has been one of the basic tasks towards this objective. In this common frame, standardized and competitive LWR NPPs could be developed and offered to the investors. This idea is now well supported by all the other actors on the European electricity market: vendors, regulators, grid managers, administrations although in the competitive and unified European electricity market that is emerging, the electricity producers' stakes are more and more different from the other electricity business actors'. The next term objectives of the electricity producers involved in EUR are focused on negotiating common rules of the game together with the regulators. This covers the nuclear safety approaches, the conditions requested to connect a plant to a HV grid, as well as the design standards. Discussions are going on between the EUR organization and all the corresponding bodies to develop stabilized and predictable design rules that would meet the constraints of nuclear electricity generation in this new environment. Finally there cannot be competition without competitors. The EUR organization has proven to be the right place to establish trustful relationship between the vendors and their potential customers, through fair assessment of the proposed designs performance vs. the utility needs. This will be continued and developed with the main vendors present in Europe, so as to keep alive a list of 4 to 6 designs 'qualified', i.e. showing an acceptable score of non-compliance vs. EUR. (authors)

  13. A Quantitative Human Spacecraft Design Evaluation Model for Assessing Crew Accommodation and Utilization

    Science.gov (United States)

    Fanchiang, Christine

    Crew performance, including both accommodation and utilization factors, is an integral part of every human spaceflight mission from commercial space tourism, to the demanding journey to Mars and beyond. Spacecraft were historically built by engineers and technologists trying to adapt the vehicle into cutting edge rocketry with the assumption that the astronauts could be trained and will adapt to the design. By and large, that is still the current state of the art. It is recognized, however, that poor human-machine design integration can lead to catastrophic and deadly mishaps. The premise of this work relies on the idea that if an accurate predictive model exists to forecast crew performance issues as a result of spacecraft design and operations, it can help designers and managers make better decisions throughout the design process, and ensure that the crewmembers are well-integrated with the system from the very start. The result should be a high-quality, user-friendly spacecraft that optimizes the utilization of the crew while keeping them alive, healthy, and happy during the course of the mission. Therefore, the goal of this work was to develop an integrative framework to quantitatively evaluate a spacecraft design from the crew performance perspective. The approach presented here is done at a very fundamental level starting with identifying and defining basic terminology, and then builds up important axioms of human spaceflight that lay the foundation for how such a framework can be developed. With the framework established, a methodology for characterizing the outcome using a mathematical model was developed by pulling from existing metrics and data collected on human performance in space. Representative test scenarios were run to show what information could be garnered and how it could be applied as a useful, understandable metric for future spacecraft design. While the model is the primary tangible product from this research, the more interesting outcome of

  14. Utility FGD survey, January--December 1989. Volume 2, Design performance data for operating FGD systems: Part 2

    Energy Technology Data Exchange (ETDEWEB)

    Hance, S.L.; McKibben, R.S.; Jones, F.M. [IT Corp., Cincinnati, OH (United States)

    1992-03-01

    This is Volume 2 part 2, of the Utility flue gas desulfurization (FGD) Survey report, which is generated by a computerized data base management system, represents a survey of operational and planned domestic utility flue gas desulfurization (FGD) systems. It summarizes information contributed by the utility industry, system and equipment suppliers, system designers, research organizations, and regulatory agencies. The data cover system design, fuel characteristics, operating history, and actual system performance. Also included is a unit-by-unit discussion of problems and solutions associated with the boilers, scrubbers, and FGD systems. This volume particularly contains basic design and performance data.

  15. Optimizing Mass Spectrometry Analyses: A Tailored Review on the Utility of Design of Experiments

    Science.gov (United States)

    Hecht, Elizabeth S.; Oberg, Ann L.; Muddiman, David

    2016-01-01

    SUMMARY Mass spectrometry (MS) has emerged as a tool that can analyze nearly all classes of molecules, with its scope rapidly expanding in the areas of post-translational modifications, MS instrumentation, and many others. Yet integration of novel analyte preparatory and purification methods with existing or novel mass spectrometers can introduce new challenges for MS sensitivity. The mechanisms that govern detection by MS are particularly complex and interdependent, including ionization efficiency, ion suppression, and transmission. Performance of both off-line and MS methods can be optimized separately or, when appropriate, simultaneously through statistical designs, broadly referred to as “design of experiments” (DOE). The following review provides a tutorial-like guide into the selection of DOE for MS experiments, the practices for modeling and optimization of response variables, and the available software tools that support DOE implementation in any laboratory. This review comes three years after the latest DOE review (Hibbert DB 2012), which provided a comprehensive overview on the types of designs available and their statistical construction. Since that time, new classes of DOE, such as the definitive screening design, have emerged and new calls have been made for mass spectrometrists to adopt the practice. Rather than exhaustively cover all possible designs, we have highlighted the three most practical DOE classes available to mass spectrometrists. This review further differentiates itself by providing expert recommendations for experimental setup and defining DOE entirely in the context of three case-studies that highlight the utility of different designs to achieve different goals. A step-by-step tutorial is also provided. PMID:26951559

  16. Pressurization Risk Assessment of CO2 Reservoirs Utilizing Design of Experiments and Response Surface Methods

    Science.gov (United States)

    Guyant, E.; Han, W. S.; Kim, K. Y.; Park, E.; Han, K.

    2015-12-01

    Monitoring of pressure buildup can provide explicit information on reservoir integrity and is an appealing tool, however pressure variation is dependent on a variety of factors causing high uncertainty in pressure predictions. This work evaluated pressurization of a reservoir system in the presence of leakage pathways as well as exploring the effects of compartmentalization of the reservoir utilizing design of experiments (Definitive Screening, Box Behnken, Central Composite, and Latin Hypercube designs) and response surface methods. Two models were developed, 1) an idealized injection scenario in order to evaluate the performance of multiple designs, and 2) a complex injection scenario implementing the best performing design to investigate pressurization of the reservoir system. A holistic evaluation of scenario 1, determined that the Central Composite design would be used for the complex injection scenario. The complex scenario evaluated 5 risk factors: reservoir, seal, leakage pathway and fault permeabilities, and horizontal position of the pathway. A total of 60 response surface models (RSM) were developed for the complex scenario with an average R2 of 0.95 and a NRMSE of 0.067. Sensitivity to the input factors was dynamic through space and time; at the earliest time (0.05 years) the reservoir permeability was dominant, and for later times (>0.5 years) the fault permeability became dominant for all locations. The RSM's were then used to conduct a Monte Carlo Analysis to further analyze pressurization risks, identifying the P10, P50, P90 values. This identified the in zone (lower) P90 values as 2.16, 1.77, and 1.53 MPa and above zone values of 1.35, 1.23, 1.09 MPa for monitoring locations 1, 2, and 3, respectively. In summary, the design of experiments and response surface methods allowed for an efficient sensitivity and uncertainty analysis to be conducted permitting a complete evaluation of the pressurization across the entire parameter space.

  17. Organizational Flexibility for Hypercompetitive Markets : Empirical Evidence of the Composition and Context Specificity of Dynamic Capabilities and Organization Design Parameters

    NARCIS (Netherlands)

    N.P. van der Weerdt (Niels)

    2009-01-01

    textabstractThis research project, which builds on the conceptual work of Henk Volberda on the flexible firm, empirically investigates four aspects of organizational flexibility. Our analysis of data of over 1900 firms and over 3000 respondents shows (1) that several increasing levels of

  18. Inglorious Empire

    DEFF Research Database (Denmark)

    Khair, Tabish

    2017-01-01

    Review of 'Inglorious Empire: What the British did to India' by Shashi Tharoor, London, Hurst Publishers, 2017, 296 pp., £20.00......Review of 'Inglorious Empire: What the British did to India' by Shashi Tharoor, London, Hurst Publishers, 2017, 296 pp., £20.00...

  19. Modeling and design of light powered biomimicry micropump utilizing transporter proteins

    Science.gov (United States)

    Liu, Jin; Sze, Tsun-Kay Jackie; Dutta, Prashanta

    2014-11-01

    The creation of compact micropumps to provide steady flow has been an on-going challenge in the field of microfluidics. We present a mathematical model for a micropump utilizing Bacteriorhodopsin and sugar transporter proteins. This micropump utilizes transporter proteins as method to drive fluid flow by converting light energy into chemical potential. The fluid flow through a microchannel is simulated using the Nernst-Planck, Navier-Stokes, and continuity equations. Numerical results show that the micropump is capable of generating usable pressure. Designing parameters influencing the performance of the micropump are investigated including membrane fraction, lipid proton permeability, illumination, and channel height. The results show that there is a substantial membrane fraction region at which fluid flow is maximized. The use of lipids with low membrane proton permeability allows illumination to be used as a method to turn the pump on and off. This capability allows the micropump to be activated and shut off remotely without bulky support equipment. This modeling work provides new insights on mechanisms potentially useful for fluidic pumping in self-sustained bio-mimic microfluidic pumps. This work is supported in part by the National Science Fundation Grant CBET-1250107.

  20. The Design Features of the Double-Banked AMBIDEXTER Utilizing DUPIC Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Ham, Tae Kyu [KHNP Central Research Institute, Daejeon (Korea, Republic of); Lee, Young Joon; Hong, Sung Taek [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Seo, Myung Hwan [Korea Radioactive Waste Agency, Daejeon (Korea, Republic of); Kwon, Tae An [KHNP, Daejeon (Korea, Republic of); Oh, Se Kee [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2016-10-15

    Since the on-site spent fuel storage capabilities at reactors in Korea are expected to be saturated in a few years, the government has been pressed to find a solution for the spent nuclear fuel. So far one of workable means for reducing the load would be utilizing DUPIC fuel cycle technology. The technology was developed through Korea-Canada-U.S. collaboration to utilize the LWR spent fuel for the CANDU reactor. However, by various sociopolitical reasons, the DUPIC technology has not been yet commercialized. As the other alternatives to use the DUPIC technology, Gen-IV reactors would be pertinent. In the following session, the design features of a molten salt reactor system that can burn DUPIC fuel are explained. The followings are derived as conclusions after considering all the factors; The AMDEC, compared to ORIGEN2 simulations, can calculate the nuclides concentration changes within 1% deviation in various core zones and reactor system components by using different library sets which are weighted with each neutron spectrum; Fuel-flow effects coupled with nuclear reactions is well reflected in the AMDEC.

  1. Design of an Optimal Waste Utilization System: A Case Study in St. Petersburg, Russia

    Directory of Open Access Journals (Sweden)

    Mikhail Rodionov

    2011-09-01

    Full Text Available Storing municipal solid waste (MSW in landfills is the oldest and still the primary waste management strategy in many countries. Russia is the third largest methane (CH4 emitter country after USA and China, representing 5% of total global CH4 emissions from waste landfilling. Due to high economical growth, the amount of waste generated in Russia has risen sharply over the last ten years. However, waste management in Russia is mainly based on landfilling. In order to design an optimal MSW utilization system considering various aspects related to sustainable MSW management, a linear programming model was introduced for this research. The performance of the proposed MSW utilization system in the target area has been evaluated in light of energy, economic, and environmental (3Es aspects, such as system net cost, annual energy generated from the waste, and the carbon dioxide (CO2 emissions of the system. St. Petersburg city was considered as the target area for the present analysis. The results show that the introduction of the proposed MSW system with energy recovery from waste along with a high level of material recovery has energy, environmental and economic benefits compared to the conventional treatment system. This paper emphasizes the importance of introducing waste treatment methods as an alternative to landfilling, and to improve recycling activities in Russia.

  2. Occupational therapists' perceptions about the clinical utility of the 3D interior design software.

    Science.gov (United States)

    Atwa, Anita; Money, Arthur G; Spiliotopoulou, Georgia; Mcintyre, Anne

    2013-07-01

    The 3D interior design software (3DIDS) is a technology, which primarily allows users to simulate their homes and visualize any changes prior to implementing them. This feasibility study aimed to examine occupational therapists' perceptions about the clinical utility of the 3DIDS. A secondary aim was to explore the attitudes of occupational therapists towards technology in general. Three focus groups were conducted with 25 occupational therapists working with older people in the UK. The qualitative data were analysed using inductive thematic analysis. The three main themes that were identified were usage and attitudes of technology, opportunities for realistic application of the 3DIDS and related threats and benefits for the occupational therapy profession. Occupational therapists had a positive attitude towards technology. They suggested that the 3DIDS could be used in discharge planning and in rehabilitation. They viewed it as a tool that could enhance their status within the health care profession and improve communication, but not as a tool that should replace the role of the occupational therapist. This research offers new and important findings about the utilization of the 3DIDS by occupational therapists and provides information as to where this technology should be trialled.

  3. Vibration Based Wind Turbine Tower Foundation Design Utilizing Soil-Foundation-Structure Interaction

    Science.gov (United States)

    Al Satari, P. E. Mohamed; Hussain, S. E. Saif

    2008-07-01

    Wind turbines have been used to generate electricity as an alternative energy source to conventional fossil fuels. This case study is for multiple wind towers located at different villages in Alaska where severe arctic weather conditions exist. The towers are supported by two different types of foundations; large mat or deep piles foundations. Initially, a Reinforced Concrete (RC) mat foundation was utilized to provide the system with vertical and lateral support. Where soil conditions required it, a pile foundation solution was devised utilizing a 30″ thick RC mat containing an embedded steel grillage of W18 beams supported by 20″-24″ grouted or un-grouted piles. The mixing and casting of concrete in-situ has become the major source of cost and difficulty of construction at these remote Alaska sites. An all-steel foundation was proposed for faster installation and lower cost, but was found to impact the natural frequencies of the structural system by significantly softening the foundation system. The tower-foundation support structure thus became near-resonant with the operational frequencies of the wind turbine leading to a likelihood of structural instability or even collapse. A detailed 3D Finite-Element model of the original tower-foundation-pile system with RC foundation was created using SAP2000. Soil springs were included in the model based on soil properties obtained from the geotechnical consultant. The natural frequency from the model was verified against the tower manufacturer analytical and the experimental values. Where piles were used, numerous iterations were carried out to eliminate the need for the RC and optimize the design. An optimized design was achieved with enough separation between the natural and operational frequencies to prevent damage to the structural system eliminating the need for any RC encasement to the steel foundation or grouting to the piles.

  4. Condicionantes en la utilización de los servicios de atención primaria: Evidencias empíricas e inconsistencias metodológicas Factors conditioning primary care services utilization: Empirical evidence and methodological inconsistencies

    Directory of Open Access Journals (Sweden)

    M. Sáez

    2003-10-01

    methodological inconsistencies that could at least partly explain the disparity of the empirical results. Among others, the following flaws can be highlighted: design problems, measurement errors, misspecification, and misleading statistical methods. Some solutions, among others, are quasi-experiments, the use of large administrative databases and of primary data sources (design problems; differentiation between types of utilization and between units of analysis other than consultations, and correction of measurement errors in the explanatory variables (measurement errors; consideration of relevant explanatory variables (misspecification; and the use of multilevel models (statistical methods.

  5. SU-C-BRB-05: Investigation of Conformal Arc Therapy Utilizing Newly Designed Cobalt 60 Machine

    Energy Technology Data Exchange (ETDEWEB)

    Eldib, A [Fox Chase Cancer Center, Philadelphia, PA (United States); Department of Physics, AlAzhar University, Cairo (Egypt); Chibani, O; Jin, L; Li, J; Veltchev, I; Price, R; Ma, C [Fox Chase Cancer Center, Philadelphia, PA (United States); Mora, G [Universidade de Lisboa, Codex, Lisboa (Portugal)

    2015-06-15

    Purpose: A new modernized design for cobalt 60 (Co-60) machines is being developed with a ring type gantry. In this study we investigate the beneficial outcome of the new design for conformal arc therapy for various clinical sites. The new modality was evaluated based on isodose distributions and dose volume histograms as compared to 6MV photon beams from conventional linear accelerators. Methods: Computed tomographic images of seven different SBRT patients were selected from our patient database. All of these cases were previously planned on the Eclipse treatment planning system. New plans for these patients were generated with a modified conformal arc technique using both 6MV and Co-60 beams. The conformal arc was created by the delivery of treatment fields conformal to the target cross-section at every 5 or 10 degrees. The field shape was modified or turned off when it initially passed through a critical structure. Monte Carlo codes, MCBEAM and MCPLAN, were used for the machine head simulation and phantom/patient dose calculation, respectively. In the new Co-60 machine design, the source-to-isocenter distance was 60cm and the treatment head included the Co-60 source, primary collimator, jaws and MLC. Results: For all cases investigated, conformal arc plans utilizing Co-60 beams achieved similar conformity (mean conformity index=1.19) comparing to 6MV photon beams. Isodose distributions were tailored similarly around the PTV; both Co-60 and 6MV plans met our clinical acceptance criteria for the target coverage, and the maximum and minimum target doses. The DVH for the Co-60 plans showed slightly lower doses to the critical structures although the differences were small in most cases. Conclusion: There were no significant dosimetric differences between 6MV and Co-60 plans. Our results confirmed that this new Co-60 design could be a cost-effective machine for advanced radiotherapy due to its low cost, low maintenance and high up time.

  6. Utilizing subcooled, superfluid He-II in the design of a 12-Tesla tandem mirror experiment

    International Nuclear Information System (INIS)

    Hoard, R.W.; Cornish, D.N.; Baldi, R.W.; Taylor, W.D.

    1981-01-01

    A design study of 12-T yin-yang coils for a conceptual Tandem Mirror Next Step facility has been recently performed by Lawrence Livermore National Laboratory in conjunction with the Convair Division of General Dynamics. The large magnets have major and mirror radii of 3.7 and 1.5 m, 0.70 x 3.75 m 2 cross section, 46.3 MA turns, and an overall current density of 1765 A/cm 2 , obtained by the use of Nb 3 Sn and Nb-Ti superconductors. Each coil is composed of several subcoils separated by internal strengthening substructure to react the enormous electromagnetic forces. The size of the yin-yang coils, and hence the current density, was reduced by utilizing subcooled, superfluid He-II at 1.8 K for the coolant. This paper reviews the design study, with emphasis on He-II heat transport and conductor stability. Methods are also presented which allow the extension of Gorter-Mellink-channel calculations to encompass multiple, interconnecting coolant channels

  7. A Decision Support System for Inbound Marketers: An Empirical Use of Latent Dirichlet Allocation Topic Model to Guide Infographic Designers

    OpenAIRE

    Nia, Meisam Hejazi

    2016-01-01

    Infographic is a type of information presentation that inbound marketers use. I suggest a method that can allow the infographic designers to benchmark their design against the previous viral infographics to measure whether a given design decision can help or hurt the probability of the design becoming viral.

  8. Effective utilization of maintenance staff in design and implementation of major project work

    International Nuclear Information System (INIS)

    Wyman, D.; Dingle, J.; Brown, R.

    1995-01-01

    The reorganization of Pickering Nuclear Division some 2 years ago resulted in the formation of the Projects and Modifications department. This department takes an integrated approach to manage all aspects of large projects at Pickering. The integration of Design, Drafting, Procurement, Construction and Operations functions into project teams represents a fundamental change to project management at Pickering. The development of integrated teams has great potential for reducing both the time and cost associated with project implementation, while at the same time improving the quality, and maintainability of the commissioned in service project. The Pickering Rehab organization 1989-1993, established to perform the rehab / retube of Units 3 and 4 had proven that a team environment will produce effective results. The outcome was astounding, critical categories such as Safety, Quality of Work, and Timeliness, had proven the team's effectiveness. The integration of operations maintenance staff into the project work activities is still evolving, and has probably required the most adaptation to change for both the former Construction and Operations organizations. Maximizing the utilization of the maintenance staff in the design and implementation of major project work will prove to be a key to a long term operating success of these projects. This paper will focus in on the effective usage of Maintenance staff in the design and implementation phases of major project work at Pickering, and on the benefits realized using this approach. It will be divided into 5 sections as indicated. 1. Past Project Shortfalls. 2. Benefits of the inclusion of Maintenance staff in the Calandria Vault Rehab Project. 3. Maintenance involvement in the Pickering 'A' Shutdown System Enhancement (SDSE) Project. 4. Challenges resulting from the inclusion of Maintenance staff project teams. 5. Summary. (author)

  9. OPEN COURSEWARE IN DESIGN AND PLANNING EDUCATION AND UTILIZATION OF DISTANCE EDUCATION OPPORTUNITY: Anadolu University Experience

    Directory of Open Access Journals (Sweden)

    Hicran Hanım HALAC

    2013-01-01

    Full Text Available Depending on the evolving technological possibilities, distance and online education applications have gradually gained more significance in the education system. Regarding the issues, such as advancements in the server services, disc capacity, cloud computing opportunities resulting from the increase in the number of the broadband internet users, web design applications; and increase in the number of mobile device and social media users and the time spent on the internet, traditional reading and working habits as well as the preferred information resources of man have considerably changed. In accordance with these changes, it has become an inevitable necessity to improve the higher education courses and learning materials. Any higher education system, which fails to keep up with these requirements, will inevitably have difficulties in providing the students with the necessary knowledge and skills within an appropriate workload frame. Within this context, one of the fields to benefit from distance and online education opportunities is undoubtedly “architecture and design education”. Although the use of computer technologies is inevasible and highly intensive in this field, the speed of conformance with the rapid technological changes and the adoption of the advancements is considerably slow compared to others. However, it is still among the fields where the technological opportunities are utilized at most. Thereby, distance and online education technologies present an essential potential to help students achieve the required planning and architectural knowledge and skills. In this respect, this article evaluates the distance and online education opportunities for design and planning education through the experience of Anadolu University.

  10. Choosing the Energy Sources Needed for Utilities in the Design and Refurbishment of Buildings

    Directory of Open Access Journals (Sweden)

    Pavel Atănăsoae

    2018-03-01

    Full Text Available This paper presents a method for choosing the energy sources that are needed for the following building utilities following building: lighting, domestic hot water, heating, ventilation, and air conditioning. The novelty of this paper consists of applying the concept of the energy hub and considering the cost of carbon dioxide emissions when selecting the available energy sources in the building’s location. The criterion for selecting the energy sources is the minimum overall cost of all forms of energy that are consumed in the building over its estimated lifetime. In order to estimate the overall costs, it is necessary to know the power that is installed and provided by the energy production technologies that are inside the building, as well as the capacity of energy that is required from outside energy sources. An office building that was proposed for refurbishment has been investigated as a case study. In the paper, we have analysed four scenarios. The results indicate that more favourable alternative solutions can be obtained compared to the traditional scenario (Scenario 4—heat and electricity by public utility networks. The overall costs are 46.17% (212,671 EUR lower in Scenario 1, 25.35% (116,770 EUR lower in Scenario 2, and 10.89% (50,150 EUR lower in Scenario 3. Additionally, the carbon dioxide emissions are 22.98% (49 tonnes CO2/year lower in Scenario 1 and 8.91% (19 tonnes CO2/year lower in Scenario 2. Thus, renewable energy sources can occupy a growing share of the total energy consumption of the building. The proposed algorithm can be used for both the refurbishment of existing buildings and the design of new buildings.

  11. Min-max optimization and the radial approach to the public service system design with generalized utility

    Directory of Open Access Journals (Sweden)

    Jaroslav Janáček

    2016-04-01

    Full Text Available The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enormous computational times or extreme memory demands when resolving this issue, we suggested and compared several approaches based on a bisection process with the purpose of developing an effective max-min approach to the public service system design with a generalized utility.

  12. Comparing Impact Findings from Design-Based and Model-Based Methods: An Empirical Investigation. NCEE 2017-4026

    Science.gov (United States)

    Kautz, Tim; Schochet, Peter Z.; Tilley, Charles

    2017-01-01

    A new design-based theory has recently been developed to estimate impacts for randomized controlled trials (RCTs) and basic quasi-experimental designs (QEDs) for a wide range of designs used in social policy research (Imbens & Rubin, 2015; Schochet, 2016). These methods use the potential outcomes framework and known features of study designs…

  13. Structuring front office and back office work in service delivery systems - An empirical study of three design decisions

    NARCIS (Netherlands)

    Zomerdijk, Leonleke G.; de Vries, Jan

    2007-01-01

    Purpose - The aim of this paper is to investigate how the distinction between contact and non-contact activities influences the design of service delivery systems and to identify key design decisions for structuring front office and back office work. Design/methodology/approach - Building on current

  14. Novel design and sensitivity analysis of displacement measurement system utilizing knife edge diffraction for nanopositioning stages.

    Science.gov (United States)

    Lee, ChaBum; Lee, Sun-Kyu; Tarbutton, Joshua A

    2014-09-01

    This paper presents a novel design and sensitivity analysis of a knife edge-based optical displacement sensor that can be embedded with nanopositioning stages. The measurement system consists of a laser, two knife edge locations, two photodetectors, and axillary optics components in a simple configuration. The knife edge is installed on the stage parallel to its moving direction and two separated laser beams are incident on knife edges. While the stage is in motion, the direct transverse and diffracted light at each knife edge is superposed producing interference at the detector. The interference is measured with two photodetectors in a differential amplification configuration. The performance of the proposed sensor was mathematically modeled, and the effect of the optical and mechanical parameters, wavelength, beam diameter, distances from laser to knife edge to photodetector, and knife edge topography, on sensor outputs was investigated to obtain a novel analytical method to predict linearity and sensitivity. From the model, all parameters except for the beam diameter have a significant influence on measurement range and sensitivity of the proposed sensing system. To validate the model, two types of knife edges with different edge topography were used for the experiment. By utilizing a shorter wavelength, smaller sensor distance and higher edge quality increased measurement sensitivity can be obtained. The model was experimentally validated and the results showed a good agreement with the theoretically estimated results. This sensor is expected to be easily implemented into nanopositioning stage applications at a low cost and mathematical model introduced here can be used for design and performance estimation of the knife edge-based sensor as a tool.

  15. Developing Multiple Diverse Potential Designs for Heat Transfer Utilizing Graph Based Evolutionary Algorithms

    Energy Technology Data Exchange (ETDEWEB)

    David J. Muth Jr.

    2006-09-01

    This paper examines the use of graph based evolutionary algorithms (GBEAs) to find multiple acceptable solutions for heat transfer in engineering systems during the optimization process. GBEAs are a type of evolutionary algorithm (EA) in which a topology, or geography, is imposed on an evolving population of solutions. The rates at which solutions can spread within the population are controlled by the choice of topology. As in nature geography can be used to develop and sustain diversity within the solution population. Altering the choice of graph can create a more or less diverse population of potential solutions. The choice of graph can also affect the convergence rate for the EA and the number of mating events required for convergence. The engineering system examined in this paper is a biomass fueled cookstove used in developing nations for household cooking. In this cookstove wood is combusted in a small combustion chamber and the resulting hot gases are utilized to heat the stove’s cooking surface. The spatial temperature profile of the cooking surface is determined by a series of baffles that direct the flow of hot gases. The optimization goal is to find baffle configurations that provide an even temperature distribution on the cooking surface. Often in engineering, the goal of optimization is not to find the single optimum solution but rather to identify a number of good solutions that can be used as a starting point for detailed engineering design. Because of this a key aspect of evolutionary optimization is the diversity of the solutions found. The key conclusion in this paper is that GBEA’s can be used to create multiple good solutions needed to support engineering design.

  16. Design and process integration of organic Rankine cycle utilizing biomass for power generation

    Science.gov (United States)

    Ependi, S.; Nur, T. B.

    2018-02-01

    Indonesia has high potential biomass energy sources from palm oil mill industry activities. The growing interest on Organic Rankine Cycle (ORC) application to produce electricity by utilizing biomass energy sources are increasingly due to its successfully used for generating electricity from rejected waste heat to the environment in industrial processes. In this study, the potential of the palm oil empty fruit bunch, and wood chip have been used as fuel for biomass to generate electricity based ORC with combustion processes. The heat from combustion burner was transfer by thermal oil heater to evaporate ORC working fluid in the evaporator unit. The Syltherm-XLT thermal oil was used as the heat carrier from combustion burner, while R245fa was used as the working fluid for ORC unit. Appropriate designs integration from biomass combustion unit to ORC unit have been analyzed and proposed to generate expander shaft-work. Moreover, the effect of recuperator on the total system efficiency has also been investigated. It was observed that the fuel consumption was increased when the ORC unit equipped recuperator operated until certain pressure and decreased when operated at high pressure.

  17. Omah displacement and utilization from rural to urban areas, as green design lifestyle

    Science.gov (United States)

    Fajarwati, Ade Ariyani Sari

    2017-11-01

    Building a house in urban area is very costly and also leaving a bunch amount of construction waste. Many efforts were made to reduce the load of this waste. However, the high demand of residences in metropolitan makes the waste problem needs to be solved together. Based on this problem, author chooses Omah, - a Javanese traditional house, which is built, based on the traditional system of life of Javanese people - displacement from rural to urban area as the alternative solution, as it uses selected materials from nature by considering the sustainability and preservation for future generation. The wooden building is built based on traditional construction system that follows Javanese principles and traditional calculation, based on philosophy and cosmology in the community. This paper will covers utilization of Omah in urban area as an implementation of green design, which refers to the concepts of reuse, reduce, recycle and responsibility. Through expert interviews and field surveys in urban and rural areas, author collected data needed for this paper. Although the functionality of the building is different from rural to urban requirements, the phenomenon of Omah displacement from Javanese habitat to urban living area is well accepted and becomes an interesting trend.

  18. Design for a sustainable society utilizing information and communication technologies (ICT) - proposal: a new EcoDesign method and its application

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, J. [Research Center for Advanced Science and Technology, the Univ. of Tokyo (Japan); Matsumoto, M. [Fundamental and Environment Labs., NEC Corp. (Japan)

    2004-07-01

    We discuss a new EcoDesign method, with a goal of improving the economy, and its application to a sustainable networked society. The new EcoDesign method differs from conventional EcoDesign in three respects: it utilizes a top-down approach, project-style research, and fact-finding and benchmarking. We systematize EcoDesign for a networked society from the viewpoint of technology and divide it into four components. Feasibility studies of the individual components reveal that if we promote ICT diffusion with EcoDesign in mind, we can suppress CO2 emissions and move towards a more sustainable society. (orig.)

  19. Evaluation and design of non-lethal laser dazzlers utilizing microcontrollers

    Science.gov (United States)

    Richardson, Keith Jack

    Current non-lethal weapons suffer from an inability to meet requirements for uses across many fields and purposes. The safety and effectiveness of these weapons are inadequate. New concepts have provided a weapon utilizing lasers to flashblind a target's visual system. Minimal research and testing have been conducted to investigate the efficiency and safety of these weapons called laser dazzlers. Essentially a laser dazzler is comprised of a laser beam that has been diverged with the use of a lens to expand the beam creating an intensely bright flashlight. All laser dazzlers to date are incapable of adjusting to external conditions automatically. This is important, because the power of these weapons need to change according to distance and light conditions. At long distances, the weapon is rendered useless because the laser beam has become diluted. At near distances, the weapon is too powerful causing permanent damage to the eye because the beam is condensed. Similarly, the eye adapts to brightness by adjusting the pupil size, which effectively limits the amount of light entering the eye. Laser eye damage is determined by the level of irradiance entering the eye. Therefore, a laser dazzler needs the ability to adjust output irradiance to compensate for the distance to the target and ambient light conditions. It was postulated if an innovative laser dazzler design could adjust the laser beam divergence then the irradiance at the eye could be optimized for maximum vision disruption with minimal risk of permanent damage. The young nature of these weapons has lead to the rushed assumptions of laser wavelengths (color) and pulsing frequencies to cause maximum disorientation. Research provided key values of irradiance, wavelength, pulsing frequency and functions for the optical lens system. In order for the laser dazzler to continuously evaluate the external conditions, luminosity and distance sensors were incorporated into the design. A control system was devised to

  20. Enhancement of collaboration activities utilizing 21st century learning design rubric

    Science.gov (United States)

    Cubero, Dave D.; Gargar, Clare V., Lady; Nallano, Gerlett Grace D.; Magsayo, Joy R.; Guarin, Rica Mae B.; Lahoylahoy, Myrna E.

    2018-01-01

    Twenty first century learners have incredibly diverse learning interests, needs, and aspirations. Engaging middle school students and sculpting successful, confident, and creative learners is a constant endeavor for educators [4]. In the 21st century classroom environments in which students can develop the skills they need in workplace. Collaboration occurs when students work together to create, discuss challenge and develop deeper critical thinking. In today's workplace, collaboration is essential as only few tasks are completed alone (Calgary and Park, 2016). The collaborative project-based curriculum used in this classroom develops the higher order thinking skills, effective communication skills, and knowledge of technology that students will need in the 21st century workplace. The study therefore aims to promote collaboration skills among learners as it is deemed as one of the top 21st century skills. Collaborative learning unleashes a unique intellectual and social synergy. This study aims to enhance the collaborative skills of students through conducting collaboration activities in learning the Ecosystem. This research utilizes pretest-posttest and employs descriptive research designs. It uses modified activities about the lesson on Ecosystem and utilizes a Collaboration Rubric to rate the modified activities. The activities were rated by ten In-Service teachers and there are 105 students who participated in doing the activities. The paired t-test is then used to analyze the data. The In-Service teachers evaluated the 1st and 2nd adapted activity and are rated as fair. Thus, the modified activities were enhanced since the ratings of each activity did not meet the criterion of the collaboration rubric. As for the 3rd adapted activity is rated as excellent and is ready for implementation. The evaluators provided comments and suggestions such as producing colored pictures on the activities, omitting some questions, and making the words simpler to enhance the

  1. Empirical likelihood

    CERN Document Server

    Owen, Art B

    2001-01-01

    Empirical likelihood provides inferences whose validity does not depend on specifying a parametric model for the data. Because it uses a likelihood, the method has certain inherent advantages over resampling methods: it uses the data to determine the shape of the confidence regions, and it makes it easy to combined data from multiple sources. It also facilitates incorporating side information, and it simplifies accounting for censored, truncated, or biased sampling.One of the first books published on the subject, Empirical Likelihood offers an in-depth treatment of this method for constructing confidence regions and testing hypotheses. The author applies empirical likelihood to a range of problems, from those as simple as setting a confidence region for a univariate mean under IID sampling, to problems defined through smooth functions of means, regression models, generalized linear models, estimating equations, or kernel smooths, and to sampling with non-identically distributed data. Abundant figures offer vi...

  2. The utility of screening in the design of trials for symptom management in cancer.

    Science.gov (United States)

    Jeon, Sangchoon; Given, Charles W; Sikorskii, Alla; Given, Barbara

    2009-10-01

    Clinical trials that test interventions for symptom management must target patients whose symptoms are severe and can benefit from participation. Screening symptoms for their severity prior to trial entry may be an important element of trial design. This research describes the utility of screening for severity of symptoms prior to entry into clinical trials for symptom management in cancer. To accomplish this, 601 cancer patients undergoing chemotherapy were assessed at screening and at the initial intervention contact, using the 0-10 rating scale for severity of nine symptoms. Post-test probabilities and likelihood ratios (LRs) were estimated across cut-offs in screening severity scores. Areas under receiver operating characteristic curves for reaching threshold of four at the initial intervention contact were estimated by a nonparametric method. It was found that screening severity scores were good predictors for identifying patients who would not reach threshold but did not always accurately predict patients who would. The cut-offs between 2 and 4 on a 0-10 scale could be used to identify patients that might benefit from receipt of interventions. For all symptoms, the LRs were greater than one across possible screening cut-offs. The findings indicate that decision rules based on screening prior to entry into cancer symptom management trials can provide reasonable discriminative accuracy by differentiating among patients who are likely to reach higher levels of severity later in the trial from those who are not. Optimal severity cut-offs can be established based on LRs and desired sensitivity and specificity.

  3. Toward a bioethical framework for antibiotic use, antimicrobial resistance and for empirically designing ethically robust strategies to protect human health: a research protocol.

    Science.gov (United States)

    Hernández-Marrero, Pablo; Martins Pereira, Sandra; de Sá Brandão, Patrícia Joana; Araújo, Joana; Carvalho, Ana Sofia

    2017-12-01

    Introduction Antimicrobial resistance (AMR) is a challenging global and public health issue, raising bioethical challenges, considerations and strategies. Objectives This research protocol presents a conceptual model leading to formulating an empirically based bioethics framework for antibiotic use, AMR and designing ethically robust strategies to protect human health. Methods Mixed methods research will be used and operationalized into five substudies. The bioethical framework will encompass and integrate two theoretical models: global bioethics and ethical decision-making. Results Being a study protocol, this article reports on planned and ongoing research. Conclusions Based on data collection, future findings and using a comprehensive, integrative, evidence-based approach, a step-by-step bioethical framework will be developed for (i) responsible use of antibiotics in healthcare and (ii) design of strategies to decrease AMR. This will entail the analysis and interpretation of approaches from several bioethical theories, including deontological and consequentialist approaches, and the implications of uncertainty to these approaches.

  4. Conceptual engineering design studies of 1985-era commercial VTOL and STOL transports that utilize rotors

    Science.gov (United States)

    Magee, J. P.; Clark, R. D.; Widdison, C. A.

    1975-01-01

    Conceptual design studies are summarized of tandem-rotor helicopter and tilt-rotor aircraft for a short haul transport mission in the 1985 time frame. Vertical takeoff designs of both configurations are discussed, and the impact of external noise criteria on the vehicle designs, performance, and costs are shown. A STOL design for the tilt-rotor configuration is reported, and the effect of removing the vertical takeoff design constraints on the design parameters, fuel economy, and operating cost is discussed.

  5. Utilities and offsites design baseline. Outside Battery Limits Facility 6000 tpd SRC-I Demonstration Plant. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-05-25

    As part of the overall Solvent Refined Coal (SRC-1) project baseline being prepared by International Coal Refining Company (ICRC), the RUST Engineering Company is providing necessary input for the Outside Battery Limits (OSBL) Facilities. The project baseline is comprised of: design baseline - technical definition of work; schedule baseline - detailed and management level 1 schedules; and cost baseline - estimates and cost/manpower plan. The design baseline (technical definition) for the OSBL Facilities has been completed and is presented in Volumes I, II, III, IV, V and VI. The OSBL technical definition is based on, and compatible with, the ICRC defined statement of work, design basis memorandum, master project procedures, process and mechanical design criteria, and baseline guidance documents. The design basis memorandum is included in Paragraph 1.3 of Volume I. The baseline design data is presented in 6 volumes. Volume I contains the introduction section and utility systems data through steam and feedwater. Volume II continues with utility systems data through fuel system, and contains the interconnecting systems and utility system integration information. Volume III contains the offsites data through water and waste treatment. Volume IV continues with offsites data, including site development and buildings, and contains raw materials and product handling and storage information. Volume V contains wastewater treatment and solid wastes landfill systems developed by Catalytic, Inc. to supplement the information contained in Volume III. Volume VI contains proprietary information of Resources Conservation Company related to the evaporator/crystallizer system of the wastewater treatment area.

  6. 75 FR 4548 - Pend Oreille County Public Utility District; Notice of Designation of Commission Staff as Non...

    Science.gov (United States)

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Pend Oreille County Public Utility District; Notice of Designation of Commission Staff as Non-Decisional January 21, 2010. Commission staff member James Hastreiter (Office of...

  7. Electric Utility Rate Design Study: EBASCO'S responses to questions from Task Force 4, Topic 4

    Energy Technology Data Exchange (ETDEWEB)

    1977-09-30

    Task Force 4 of the Electric Utility Rate Design Study generated questions for EBASCO dealing with the report, Costing for Peak Load Pricing: Topic 4, Results for Virginia Electric Power Company, June 6, 1977. Questions and answers are reported here and are for general information of the industry.

  8. The design of a comprehensive microsimulator of household vehicle fleet composition, utilization, and evolution.

    Science.gov (United States)

    2012-01-01

    The report describes a comprehensive vehicle fleet composition, utilization, and evolution : simulator that can be used to forecast household vehicle ownership and mileage by type of : vehicle over time. The components of the simulator are developed ...

  9. Preliminary design and analysis of aluminum-air cells providing for continuous feed and full utilization of anodes

    Science.gov (United States)

    Cooper, J. F.

    1981-08-01

    The advantages, disadvantages, and engineering problem areas of the wedge shaped cells in anodes utilization are reviewed. The importance of solution side current collection to the practicality of this approach when used with alkaline electrolytes is identified. The relationship between cell height and total anode mass is derived for this and corresponding cells of the M1 design. It is concluded that the M1-CF design may provide the basis for an automotive battery of greater simplicity, reliability, and economy than earlier designs.

  10. Empirical Hamiltonians

    International Nuclear Information System (INIS)

    Peggs, S.; Talman, R.

    1987-01-01

    As proton accelerators get larger, and include more magnets, the conventional tracking programs which simulate them run slower. The purpose of this paper is to describe a method, still under development, in which element-by-element tracking around one turn is replaced by a single man, which can be processed far faster. It is assumed for this method that a conventional program exists which can perform faithful tracking in the lattice under study for some hundreds of turns, with all lattice parameters held constant. An empirical map is then generated by comparison with the tracking program. A procedure has been outlined for determining an empirical Hamiltonian, which can represent motion through many nonlinear kicks, by taking data from a conventional tracking program. Though derived by an approximate method this Hamiltonian is analytic in form and can be subjected to further analysis of varying degrees of mathematical rigor. Even though the empirical procedure has only been described in one transverse dimension, there is good reason to hope that it can be extended to include two transverse dimensions, so that it can become a more practical tool in realistic cases

  11. The Empire Strikes Back

    DEFF Research Database (Denmark)

    Micklitz, Hans-W.; Pałka, Przemysław; Panagis, Yannis

    2017-01-01

    The authors argue that it is possible to partly automate the process of abstract control of fairness of clauses in online consumer contracts. The authors present a theoretical and empirical argument for this claim, including a brief presentation of the software they have designed. This type...

  12. Empirical performance of the self-controlled case series design: lessons for developing a risk identification and analysis system.

    Science.gov (United States)

    Suchard, Marc A; Zorych, Ivan; Simpson, Shawn E; Schuemie, Martijn J; Ryan, Patrick B; Madigan, David

    2013-10-01

    The self-controlled case series (SCCS) offers potential as an statistical method for risk identification involving medical products from large-scale observational healthcare data. However, analytic design choices remain in encoding the longitudinal health records into the SCCS framework and its risk identification performance across real-world databases is unknown. To evaluate the performance of SCCS and its design choices as a tool for risk identification in observational healthcare data. We examined the risk identification performance of SCCS across five design choices using 399 drug-health outcome pairs in five real observational databases (four administrative claims and one electronic health records). In these databases, the pairs involve 165 positive controls and 234 negative controls. We also consider several synthetic databases with known relative risks between drug-outcome pairs. We evaluate risk identification performance through estimating the area under the receiver-operator characteristics curve (AUC) and bias and coverage probability in the synthetic examples. The SCCS achieves strong predictive performance. Twelve of the twenty health outcome-database scenarios return AUCs >0.75 across all drugs. Including all adverse events instead of just the first per patient and applying a multivariate adjustment for concomitant drug use are the most important design choices. However, the SCCS as applied here returns relative risk point-estimates biased towards the null value of 1 with low coverage probability. The SCCS recently extended to apply a multivariate adjustment for concomitant drug use offers promise as a statistical tool for risk identification in large-scale observational healthcare databases. Poor estimator calibration dampens enthusiasm, but on-going work should correct this short-coming.

  13. Conceptual design studies of 1985 commercial VTOL transports that utilized rotors, Volume 1

    Science.gov (United States)

    Magee, J. P.; Clark, R. D.; Alexander, H. R.

    1974-01-01

    Results of conceptual design studies of commercial rotary wing transport aircraft for the 1985 time period are presented. Two aircraft configurations, a tandem helicopter and a tilt rotor, were designed for a 200 nautical mile short haul mission with an upper limit of 100 passengers. In addition to the baseline aircraft two further designs of each configuration are included to assess the impact of external noise design criteria on the aircraft size, weight, and cost.

  14. Conceptual design studies of 1985 commercial VTOL transports that utilized rotors, Volume 2

    Science.gov (United States)

    Magee, J. P.; Clark, R.; Alexander, H. R.

    1974-01-01

    Results of conceptual design studies of tilt rotor and tandem helicopter aircraft for a 200 nautical mile commercial short haul transport mission are presented. The trade study data used in selecting the design point aircraft and technology details necessary to support the design conclusions are included.

  15. Continual reassessment method vs. traditional empirically based design: modifications motivated by Phase I trials in pediatric oncology by the Pediatric Brain Tumor Consortium.

    Science.gov (United States)

    Onar, Arzu; Kocak, Mehmet; Boyett, James M

    2009-01-01

    In this article we provide additional support for the use of a model-based design in pediatric Phase I trials and present our modifications to the continual reassessment method (CRM), which were largely motivated by specific challenges we encountered in the context of the Pediatric Brain Tumor Consortium trials. We also summarize the results of our extensive simulations studying the operating characteristics of our modified approach and contrasting it to the empirically based traditional method (TM). Compared to the TM, our simulations indicate that the modified version of CRM is more accurate, exposes fewer patients to potentially toxic doses, and tends to require fewer patients. Further, the CRM-based MTD has a consistent definition across trials, which is important, especially in a consortium setting where multiple agents are being tested in studies that are often running simultaneously and accruing from the same patient population.

  16. Design of solar thermal systems utilizing pressurized hot water storage for industrial applications

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, Govind N.; Kedare, Shireesh B.; Bandyopadhyay, Santanu [Energy Systems Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai 400 076 (India)

    2008-08-15

    A large number of industrial processes demand thermal energy in the temperature range of 80-240{sup o}C. In this temperature range, solar thermal systems have a great scope of application. However, the challenge lies in the integration of a periodic, dilute and variable solar input into a wide variety of industrial processes. Issues in the integration are selection of collectors, working fluid and sizing of components. Application specific configurations are required to be adopted and designed. Analysis presented in this paper lays an emphasis on the component sizing. The same is done by developing a design procedure for a specific configuration. The specific configuration consists of concentrating collectors, pressurized hot water storage and a load heat exchanger. The design procedure follows a methodology called design space approach. In the design space approach a mathematical model is built for generation of the design space. In the generation of the design space, design variables of concern are collector area, storage volume, solar fraction, storage mass flow rate and heat exchanger size. Design space comprises of constant solar fraction curves traced on a collector area versus storage volume diagram. Results of the design variables study demonstrate that a higher maximum storage mass flow rates and a larger heat exchanger size are desired while limiting storage temperature should be as low as possible. An economic optimization is carried out to design the overall system. In economic optimization, total annualized cost of the overall system has been minimized. The proposed methodology is demonstrated through an illustrative example. It has been shown that 23% reduction in the total system cost may be achieved as compared to the existing design. The proposed design tool offers flexibility to the designer in choosing a system configuration on the basis of desired performance and economy. (author)

  17. Designing incentives in local public utilities, an international comparison of the drinking water sector

    NARCIS (Netherlands)

    de Witte, K.; Marques, R.C.

    2007-01-01

    Cross-country comparisons avoid the unsteady equilibrium in which regulators have to balance between economies of scale and a sufficient number of remaining comparable utilities. By the use of Data Envelopment Analysis (DEA), we compare the efficiency of the drinking water sector in the Netherlands,

  18. Designing an electricity tax system in presence of international regulations and multiple public goals: An empirical assessment

    International Nuclear Information System (INIS)

    Bjertnaes, Geir H.; Faehn, Taran; Aasness, Jorgen

    2008-01-01

    The European competition rules restrict governments' opportunity to differentiate terms of energy accessibility among firms and industries. This easily runs counter with regional and industrial goals of national energy policies. Norway levies a tax on use of electricity, but exempts main industrial usages. This analysis assesses alternative, internationally legal, designs of the system in terms of their effects on efficiency and distribution, including industrial objectives. Among the reforms we explore, removing the exemptions would be the most effective way of raising revenue, but it would be politically costly by deteriorating the competitiveness of today's favoured industries. An entire abolishment of the electricity tax, and replacing revenue by increased VAT, would generate a more equal distribution of standard of living and, at the same time, avoid the trade-off between efficiency and competitiveness

  19. Empirical evaluation of selective DNA pooling to map QTL in dairy cattle using a half-sib design by comparison to individual genotyping and interval mapping

    Directory of Open Access Journals (Sweden)

    Robinson Nicholas

    2007-04-01

    Full Text Available Abstract This study represents the first attempt at an empirical evaluation of the DNA pooling methodology by comparing it to individual genotyping and interval mapping to detect QTL in a dairy half-sib design. The findings indicated that the use of peak heights from the pool electropherograms without correction for stutter (shadow product and preferential amplification performed as well as corrected estimates of frequencies. However, errors were found to decrease the power of the experiment at every stage of the pooling and analysis. The main sources of errors include technical errors from DNA quantification, pool construction, inconsistent differential amplification, and from the prevalence of sire alleles in the dams. Additionally, interval mapping using individual genotyping gains information from phenotypic differences between individuals in the same pool and from neighbouring markers, which is lost in a DNA pooling design. These errors cause some differences between the markers detected as significant by pooling and those found significant by interval mapping based on individual selective genotyping. Therefore, it is recommended that pooled genotyping only be used as part of an initial screen with significant results to be confirmed by individual genotyping. Strategies for improving the efficiency of the DNA pooling design are also presented.

  20. Maximizing the utilization and impact of medical educational software by designing for local area network (LAN) implementation.

    OpenAIRE

    Stevens, R.; Reber, E.

    1993-01-01

    The design, development and implementation of medical education software often occurs without sufficient consideration of the potential benefits that can be realized by making the software network aware. These benefits can be considerable and can greatly enhance the utilization and potential impact of the software. This article details how multiple aspects of the IMMEX problem solving project have benefited from taking maximum advantage of LAN resources.

  1. Utility gas turbine combustor viewing system: Volume 1, Conceptual design and initial field testing: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Morey, W.W.

    1988-12-01

    This report summarizes the development and field testing of a combustor viewing probe (CVP) as a flame diagnostic monitor for utility gas turbine engines. The prototype system is capable of providing a visual record of combustor flame images, recording flame spectral data, analyzing image and spectral data, and diagnosing certain engine malfunctions. The system should provide useful diagnostic information to utility plant operators, and reduce maintenance costs. The field tests demonstrated the ability of the CVP to monitor combustor flame condition and to relate changes in the engine operation with variations in the flame signature. Engine light off, run up to full speed, the addition of load, and the effect of water injection for NO/sub x/ control could easily be identified on the video monitor. The viewing probe was also valuable in identifying hard startups and shutdowns, as well as transient effects that can seriously harm the engine. 11 refs.

  2. Occupants’ Utilization of Natural Ventilation: A Study of Selected Terrace House Designs in Hot-humid Climate

    Directory of Open Access Journals (Sweden)

    Ibiyeye AI

    2015-05-01

    Full Text Available With increased time spent indoors and demand for enhanced comfort levels, energy consumption in homes is rising mostly for cooling, particularly in hot-humid regions. Natural ventilation is seen as an alternative to mechanical cooling as it is totally independent on energy and has been reported to be of high potential. However, little information is available on the utilization of natural ventilation in individual living spaces in different house designs. Therefore, this paper aims to investigate occupants’ utilization of natural ventilation in living spaces under different terrace house designs in hot-humid climate and also the relationship between the openings and occupants’ satisfaction with natural ventilation. Five (5 different terrace house types in Putrajaya, Malaysia with different opening design characteristics were selected for the study. A total of 298 households from these house types were surveyed and results show that occupants mostly open their windows during the daytime to capture breeze from outside despite the fact that they owned air-conditioners. In terms of occupants’ level of satisfaction with indoor ventilation when utilizing natural ventilation, majority rated neither satisfied nor unsatisfied. Further regression analysis reveals that this level of satisfaction is significantly related to opening sizes that are in accordance with the law, duration of opening windows and AC ownership. Findings from this study will shed more light on behavioural pattern of occupants of residential buildings towards natural ventilation provisions and highlight the importance of conforming to the law governing them.

  3. Uncertainty analysis in raw material and utility cost of biorefinery synthesis and design

    DEFF Research Database (Denmark)

    Cheali, Peam; Quaglia, Alberto; Gernaey, Krist

    2014-01-01

    are characterized by considerable uncertainty. These uncertainties might have significant impact on the results of the design problem, and therefore need to be carefully evaluated and managed, in order to generate candidates for robust design. In this contribution, we study the effect of data uncertainty (raw...

  4. Designing a Relational Database to Facilitate Military Family Housing Utilization Decisions

    Science.gov (United States)

    2001-06-01

    more powerful applications, such as Dreamweaver for Web design and Oracle for the database. Although FrontPage is easy to use, it is not as robust...as Dreamweaver , which is preferred by the majority of professional Web designers. As for the database application, Oracle’s database is far superior

  5. Why reliability is the most important aspect of fuel design for a utility

    International Nuclear Information System (INIS)

    Pilat, E.E.

    1987-01-01

    Official fuel design improvements have proliferated in recent years. The US Nuclear Regulatory Commission's 1985 report states that A wide variety of fuel design changes are being studied by domestic fuel vendors, the Electric Power Research Institute (EPRI), and the US Department of Energy (DOE). Perhaps some of this is in the nomenclature - what used to be called minor modifications are now called product lines. Nevertheless, the emphasis on the individuality of the different designs serves well to alert us to the fact that fuel design is still an art as well as a science, and that small changes in individual components can make significant changes in the overall operating characteristics. Yankee Atomic Electric Company tends to evaluate fuel designs by the way that they rate on the three R's of fuel performance: reliability, reliability, and reliability. Three reasons for this attitude are discussed

  6. A Design of High-Power Beam Combiner at Millimeter Wavelengths Utilizing Wire Grids

    Science.gov (United States)

    Lin, Mei; Yu, Yanzhong

    2009-05-01

    A beam combiner, which can combine multiple Gaussian beams into a single one, has many important applications, such as high-power radar and weapon. In this paper, we propose a new scheme of the design of high-power beam combiner at millimeter wavelengths by using wire grids. The design tool is to combine a genetic algorithm (GA) for global optimization and an Ansoft HFSS for rigorous electromagnetic computation. The design method is described in detail and the optimized results are presented. Finally, a brief summary is given.

  7. Design of a high-temperature superconductor current lead for electric utility SMES

    International Nuclear Information System (INIS)

    Niemann, R.C.; Cha, Y.S.; Hull, J.R.; Rey, C.M.; Dixon, K.D.

    1995-01-01

    Current leads that rely on high-temperature superconductors (HTSs) to deliver power to devices operating at liquid helium temperature have the potential to reduce refrigeration requirements to levels significantly below those achievable with conventional leads. The design of HTS current leads suitable for use in near-term superconducting magnetic energy storage (SMES) is in progress. The SMES system has an 0.5 MWh energy capacity and a discharge power of 30 MW. Lead-design considerations include safety and reliability, electrical and thermal performance, structural integrity, manufacturability, and cost. Available details of the design, including materials, configuration, and performance predictions, are presented

  8. Empire Redux

    DEFF Research Database (Denmark)

    Mercau, Ezequiel

    from the legacies of empire. Taking decolonization as a starting point, this thesis demonstrates how the idea of a ‘British world’ gained a new lease of life vis-à-vis the Falklands, as the Islanders adopted the rhetorical mantle of ‘abandoned Britons’. Yet this new momentum was partial and fractured......The Falklands War was shrouded in symbolism and permeated with imperial rhetoric, imagery and memories, bringing to the fore divergent conceptions of Britishness, kinship and belonging. The current dispute, moreover, is frequently framed in terms of national identity, and accusations of imperialism......, as evinced by the developments triggered by the Argentine invasion in 1982. Despite the apparent firmness of the British government’s commitment to the Islands, cracks and fissures over the meaning of Britishness were simultaneously magnified. The perceived temporal dislocation of defending loyal Britons...

  9. Economical concrete mix design utilizing blended cements, performance-based specifications, and pay factors.

    Science.gov (United States)

    2013-05-01

    This report showcases several new approaches of using materials science and structural mechanics to accomplish : sustainable design of concrete materials. The topics addressed include blended cements, fiber-reinforced concrete : (FRC), internal curin...

  10. Design of a Binocular Pupil and Gaze Point Detection System Utilizing High Definition Images

    Directory of Open Access Journals (Sweden)

    Yilmaz Durna

    2017-05-01

    Full Text Available This study proposes a novel binocular pupil and gaze detection system utilizing a remote full high definition (full HD camera and employing LabVIEW. LabVIEW is inherently parallel and has fewer time-consuming algorithms. Many eye tracker applications are monocular and use low resolution cameras due to real-time image processing difficulties. We utilized the computer’s direct access memory channel for rapid data transmission and processed full HD images with LabVIEW. Full HD images make easier determinations of center coordinates/sizes of pupil and corneal reflection. We modified the camera so that the camera sensor passed only infrared (IR images. Glints were taken as reference points for region of interest (ROI area selection of the eye region in the face image. A morphologic filter was applied for erosion of noise, and a weighted average technique was used for center detection. To test system accuracy with 11 participants, we produced a visual stimulus set up to analyze each eye’s movement. Nonlinear mapping function was utilized for gaze estimation. Pupil size, pupil position, glint position and gaze point coordinates were obtained with free natural head movements in our system. This system also works at 2046 × 1086 resolution at 40 frames per second. It is assumed that 280 frames per second for 640 × 480 pixel images is the case. Experimental results show that the average gaze detection error for 11 participants was 0.76° for the left eye, 0.89° for right eye and 0.83° for the mean of two eyes.

  11. An optimal two-stage phase II design utilizing complete and partial response information separately.

    Science.gov (United States)

    Panageas, Katherine S; Smith, Alex; Gönen, Mithat; Chapman, Paul B

    2002-08-01

    Phase II clinical trials in oncology are performed to evaluate the therapeutic efficacy of a new treatment regimen. A common measure of efficacy for these trials is the proportion of patients who obtain a response measured by tumor shrinkage. It is standard practice to classify this response into the following categories: (1) complete response (CR); (2) partial response (PR); (3) stable disease; and (4) progression of disease. Tumor response is then treated as a binary variable whereby patients who achieve either a CR or a PR are considered responders and all others nonresponders. A two-stage design that allows for early termination of the trial if the treatment shows little efficacy such as Gehan or Simon gives equal weight to a CR and a PR. However, a CR, defined as complete disappearance of the tumor, is more likely than a PR to signal an important antitumor effect and result in a survival advantage. We argue that CRs and PRs should be considered separately, and hence we propose a two-stage design with a multilevel endpoint (i.e., CR, PR, and nonresponders). This design is an extension of Simon's optimal two-stage design and is based on a trinomial model. For most scenarios the proposed design results in an improvement in expected sample size compared to Simon's optimal design. Design optimization was performed by a direct search based on enumerating exact trinomial probabilities. Sample size tables are provided for parameter sets commonly used in the oncologic setting. Software is available by contacting the authors.

  12. Conceptual Design of Hybrid Safety Features for NPP by Utilizing Solar Updraft Tower

    Energy Technology Data Exchange (ETDEWEB)

    Song, Sub Lee [Handong Global University, Pohang (Korea, Republic of); Choi, Young Jae; Kim, Yong Jin [KAIST, Daejeon (Korea, Republic of); Park, Hyo Chan; Park, Youn Won [BEES, Daejeon (Korea, Republic of)

    2016-05-15

    In this study, hybrid safety features for NPP with solar updraft tower (SUT) is conceptually suggested to cope with loss of ultimate heat sink accident. The hybrid safety features utilizing SUT target NPPs in seashore of Arabian Gulf. Usually NPPs are constructed near seashore to utilize sea water as an ultimate heat sink. Residual heat or decay heat of nuclear reactor will diffuse into the ocean through the condenser. NPPs in Middle East are expected to be placed in seashore of Arabian Gulf. The NPP site of Barakah is an actual example. For NPPs in seashore of Arabian Gulf, an additional safety concern should be considered. Arabian Gulf is the largest oil transporting route in the world. The oil spill risk in Arabian Gulf will be the largest simultaneously. Unfortunately, not like other oceans, Arabian Gulf is a kind of closed ocean which does not have strong ocean currents connected to out of the gulf. If once oil spill is occurred, its influence can be propagated more than our expectation. The spilled oil also can affect to NPPs in seashore by covering surfaces of condenser. It will directly cause loss of ultimate heat sink. The hybrid safety features of SUT system are expected to aid normal operation of safety system and mitigate consequence of severe accident. Detail analysis and technology development is ongoing now.

  13. Design of IP Camera Access Control Protocol by Utilizing Hierarchical Group Key

    Directory of Open Access Journals (Sweden)

    Jungho Kang

    2015-08-01

    Full Text Available Unlike CCTV, security video surveillance devices, which we have generally known about, IP cameras which are connected to a network either with or without wire, provide monitoring services through a built-in web-server. Due to the fact that IP cameras can use a network such as the Internet, multiple IP cameras can be installed at a long distance and each IP camera can utilize the function of a web server individually. Even though IP cameras have this kind of advantage, it has difficulties in access control management and weakness in user certification, too. Particularly, because the market of IP cameras did not begin to be realized a long while ago, systems which are systematized from the perspective of security have not been built up yet. Additionally, it contains severe weaknesses in terms of access authority to the IP camera web server, certification of users, and certification of IP cameras which are newly installed within a network, etc. This research grouped IP cameras hierarchically to manage them systematically, and provided access control and data confidentiality between groups by utilizing group keys. In addition, IP cameras and users are certified by using PKI-based certification, and weak points of security such as confidentiality and integrity, etc., are improved by encrypting passwords. Thus, this research presents specific protocols of the entire process and proved through experiments that this method can be actually applied.

  14. Design and evaluation of heat utilization systems for the high temperature engineering test reactor

    International Nuclear Information System (INIS)

    2001-08-01

    The primary focus of this CRP was to perform detailed investigation of the high temperature industrial processes that are attainable through incorporation of an HTGR, and for their possible demonstration in the HTTR. The HTGR has the capability to achieve a core outlet temperature approaching 1,000 deg. C in a safe and effective manner. These attributes, coupled with the offer by JAERI to utilize the HTTR, resulted in the initiation of this CRP by the IAEA. High Temperature Engineering Test Reactor (HTTR) utilizes a 30 MW(th) HTGR comprised of 30 fuel columns of hexagonal pin-in-pin graphite block type fuel elements. The fuel consists of UO 2 TRISO coated particles with an enrichment of ∼ 6% wt. Relative to the demonstration of high temperature heat applications, the HTTR will be capable of producing 10 MW(th) of heat at 950 deg. C. However, the thermal power for these applications has the potential to be increased up to 30 MW(th) in the future, which may be required for demonstration of gas turbine system components. The HTTR reached initial criticality in November 1998. Initial operational plans includes a series of rise to power tests followed by tests to demonstrate the safety and operational characteristics of the HTTR. In addition to completion of the HTTR demonstration tests, it was recommended that the R and D be performed within the HTTR project. JAERI is encouraged to publicize the results of the HTTR tests and 'lessons learned' from their experiences including potential capabilities of the HTGR for heat applications. The next priority application was determined to be the generation of electricity through the use of the gas turbine. Application of the Brayton Cycle utilizing high temperature helium from a modular HTGR was chosen for development because of its projected benefits as an economic and efficient means for the production of electricity. Evaluation of the remaining high temperature heat utilization applications chosen for investigation resulted

  15. Formulation and Design of a CO2 Utilization Network Detailed Through a Conceptual Example

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Fjellerup, Kasper; Gani, Rafiqul

    information is available to describe the network mathematically, the most promising paths based on known technologies are designed and analyzed first. This makes the stages iterative rather than purely sequential. As part of this, the network is analyzed in the conceptual example of methanol synthesis via CO2...... for economic feasibility and environmental sustainability. Using computer-aided methods, the feasibility and sustainability of CO2 conversion is shown through the design and optimization of a methanol synthesis process....... involves three stages: a process synthesis stage, a design stage and an innovation stage. Following a superstructure based approach, a network of conversion processes is created. This network links CO2 and products through various processing blocks. The network also links carbon capture to ensure...

  16. Design and construction of a demonstration residence utilizing natural thermal storage

    Science.gov (United States)

    Jones, R. F.; Ghaffari, H. T.

    The Brookhaven House is an energy conserving residence which demonstrates how thermal mass combined with solar energy can be used to reduce heating costs in a conventional single family house. The purpose of the project was to develop a prototypical house design that could result in immediate energy savings by being an acceptable, attractive design to developers, builders, and home buyers. Investigations were limited to only materials and methods of construction that were considered presently available and of Natural Thermal Storage design. Natural thermal storage is simply the heat storage obtained through architectural application of massive building materials integrated into the living space and structure of a residence. It has been concluded that relatively thin mass walls of masonry directly irradiated through a multiglazed south facing aperture can significantly reduce annual heating requirements.

  17. Application of a computer-aided framework for the design of CO2 capture and utilization processes

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Woodley, John; Gani, Rafiqul

    2017-01-01

    Carbon dioxide capture and utilization is a vital element of carbon dioxide emission reduction to address global warming. An integrated, computer-aided framework has been developed to achieve this. This framework adopts a three-stage approach to sustainable process synthesis-design: (i) process...... synthesis, (ii) process design and (iii) innovative design. In the first stage, reaction path synthesis is used to determine the reactions and products that are considered in processing route selection and/or generation. Various scenarios are then considered for the superstructure optimization. The selected...... steps. Then, the superstructure optimization is performed on a network containing 13 likely products giving 30 feasible processing routes, considering different scenarios and objectives. Stages 2 and 3 have been applied to the optimal solution of the first scenario, which selects the production...

  18. Wind-tunnel evaluation of an advanced main-rotor blade design for a utility-class helicopter

    Science.gov (United States)

    Yeager, William T., Jr.; Mantay, Wayne R.; Wilbur, Matthew L.; Cramer, Robert G., Jr.; Singleton, Jeffrey D.

    1987-01-01

    An investigation was conducted in the Langley Transonic Dynamics Tunnel to evaluate differences between an existing utility-class main-rotor blade and an advanced-design main-rotor blade. The two rotor blade designs were compared with regard to rotor performance oscillatory pitch-link loads, and 4-per-rev vertical fixed-system loads. Tests were conducted in hover and over a range of simulated full-scale gross weights and density altitude conditions at advance ratios from 0.15 to 0.40. Results indicate that the advanced blade design offers performance improvements over the baseline blade in both hover and forward flight. Pitch-link oscillatory loads for the baseline rotor were more sensitive to the test conditions than those of the advanced rotor. The 4-per-rev vertical fixed-system load produced by the advanced blade was larger than that produced by the baseline blade at all test conditions.

  19. Low NO{sub x}/SO{sub x} Burner retrofit for utility cyclone boilers. Public design report

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    This Public Design Report provides available nonproprietary design information on the Low NO{sub x}SO{sub x} Burner Retrofit of Utility Cyclone Boilers project. In addition to the design aspects, the history of the project, the organization of the project, and the role of the funding parties are discussed. An overview of the Low NO{sub x}SO{sub x} (LNS) Burner, the cyclone boiler and the Southern Illinois Power Cooperative host site is presented. A detailed nonproprietary description of the individual process steps, plant systems, and resulting performance then follows. Narrative process descriptions, simplified process flow diagrams, input/output stream data, operating conditions and requirements are given for each unit. The plant demonstration program and start up provisions, the environmental considerations and control, monitoring and safety factors that are considered are also addressed.

  20. Design of the Remote Climate Control System for Cultural Buildings Utilizing ZigBee Technology

    Directory of Open Access Journals (Sweden)

    Jingcheng ZHANG

    2010-07-01

    Full Text Available A wireless solution of remote climate control for cultural buildings is presented in this paper. The system allows users to use web service to control climate in different cultural buildings, like churches. The wireless sensor networks deployed in churches receive the control commands and manage the indoor climate. The whole system is modularly designed, which makes possible an easy service extension, system reconfiguration and modification. This paper includes the system overview and the software design of each part within the system.

  1. Design and fabrication of the PDX poloidal field solenoid utilizing fiberglass reinforced epoxy

    International Nuclear Information System (INIS)

    Young, K.S.C.

    1975-11-01

    This paper discusses the basic design of the Poloidal Field Solenoid Coil. It will be mainly concerned with the more unique features of the Solenoid such as the copper coil windings and the design of the epoxy-glass structural support mandrels. The center solenoid coil of the PDX machine consists of five different coil systems (OH No. 8, No. 9; NF No. 11; DF No. 7; EF Solenoid and CF No. 9). Three concentric fiberglass reinforced epoxy cylinders fabricated in-house will act as mandrels to support and to house the coils that will result as an integral unit

  2. A generic methodology for the design of sustainable carbon dioxide utilization processes using superstructure optimization

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Gani, Rafiqul

    Global warming and other environmental concerns are fueling increased focus on sustainability resulting in new and stringent guidelines, especially with regard to emissions [1]. Greenhouse gases are prevalent and among harmful emissions that are targeted to be reduced; carbon dioxide (CO2...... of feedstock [4], in this case carbon dioxide. This stage contains three steps, each incorporating relevant methods and tools. First, with the help of user specifications, the problem is specified. Then, the processing routes linking feed and product are represented via a superstructure. This is performed....... This database contains information on the raw material (including different carbon dioxide emission conditions), the products and the reactions linking these. With this help of the database it is possible to quickly compare utilization processes for a specific problem as the information is easily accessible...

  3. 76 FR 44763 - Authority To Designate Financial Market Utilities as Systemically Important

    Science.gov (United States)

    2011-07-27

    ... considerations will be taken into account in assessing systemic importance. Consideration (A): Aggregate Monetary... stability of the financial system of the United States (the ``Second Determination''). Considerations (A... ``Financial Services Roundtable letter''), p. 3. Section 1320.10 Factors for Consideration in Designation In...

  4. Advanced system demonstration for utilization of biomass as an energy source. Volume IV. Design drawings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    This volume contains design drawings for the biomass cogeneration plant to be built in Maine. The drawings show a considerable degree of detail, however, they are not to be considered released for construction. There has been no actual procurement of equipment, therefore equipment drawings certified by suppliers have not been included. (DMC)

  5. ERTS-B (Earth Resources Technology Satellite). [spacecraft design remote sensor description, and technology utilization

    Science.gov (United States)

    1975-01-01

    Mission plans and objectives of the ERTS 2 Satellite are presented. ERTS 2 follow-on investigations in various scientific disciplines including agriculture, meteorology, land-use, geology, water resources, oceanography, and environment are discussed. Spacecraft design and its sensors are described along with the Delta launch vehicle and launch operations. Applications identified from ERTS 1 investigations are summarized.

  6. Utility view on QA/QC of WWER-440 fuel design and manufacture

    International Nuclear Information System (INIS)

    Vesely, P.

    1999-01-01

    In this lecture the legislation implements in the Czech Republic, QA/QC system at CEZ, demonstration and development program (purchaser point of view), audit of QA/QC system for fuel design and manufacturing as well as QA/QC records are discussed

  7. Instructional design in mathematics for undergraduate students based on learning by mistakes approach utilizing scilab assistance

    Science.gov (United States)

    Kartika, H.

    2018-03-01

    The issue related to making mistake while learning such as negative emotion is found while students learn mathematics with the aid of a computer. When the computer output showed a mistake message, the students considered it as a computer software malfunction. Based on this issue, the writer designs an instructional model based on learning by mistake approach and which is Scilab assisted. The method used in this research is research design involving undergraduate students in matrix algebra courses. The data collected throught survey with questionnaire to gain feedback about the approach implemented. The data analyzed using quantitative descriptive. The instructional design proposed is the student act as a mistake corrector while the teacher acts as a mistake maker. Teacher deliberately makes mistakes with the help of Scilab software. On the other hand, students correct, analyze and explain errors resulting from Scilab software. The result of this research is an ICT based instructional design which is expected to be applicable as an alternative learning in directing students to think positively about mistakes in learning. Furthermore, students are also expected to improve their ability in understanding and thinking critically while solving problems and improving themselves in learning mathematics.

  8. [Impact of primary care oriented outpatient benefit package design in new rural cooperative medical system on hypertension outpatient services utilization].

    Science.gov (United States)

    Tang, Shu-nv; Jian, Wei-yan; Yip, Winnie C-M; Guo, Yan

    2014-06-18

    To study the impact of primary care oriented outpatient benefits package design of outpatient services coverage and ladder reimbursement of county, town and village levels in the new rural cooperative medical system (NRCMs) on hypertension outpatient services utilization. The panel data of treatment and control groups in 2009 and 2011 before and after the policy reform were drawn from the household survey data of the innovative payment system project. The difference in difference (DID) method was used for data analysis. The outcome indicators included the utilization of outpatient services of patients with self-reported hypertension and their main treatment locations. The primary care oriented outpatient benefit package design in the NRCMs reduced the probability of no treatment in the latest three months of hypertension by 10.2 percent points. Meanwhile, it increased the probability of choosing village clinic as the preferred location by 15.7 percent points. Primary care oriented outpatient benefits package design lead patients with hypertension to use the nearest outpatient services at low risk of disease.

  9. Nonlinear Power Flow Control Design Utilizing Exergy, Entropy, Static and Dynamic Stability, and Lyapunov Analysis

    CERN Document Server

    Robinett III, Rush D

    2011-01-01

    Nonlinear Powerflow Control Design presents an innovative control system design process motivated by renewable energy electric grid integration problems. The concepts developed result from the convergence of three research and development goals: • to create a unifying metric to compare the value of different energy sources – coal-burning power plant, wind turbines, solar photovoltaics, etc. – to be integrated into the electric power grid and to replace the typical metric of costs/profit; • to develop a new nonlinear control tool that applies power flow control, thermodynamics, and complex adaptive systems theory to the energy grid in a consistent way; and • to apply collective robotics theories to the creation of high-performance teams of people and key individuals in order to account for human factors in controlling and selling power into a distributed, decentralized electric power grid. All three of these goals have important concepts in common: exergy flow, limit cycles, and balance between compe...

  10. Removal of Supernumerary Teeth Utilizing a Computer-Aided Design/Computer-Aided Manufacturing Surgical Guide.

    Science.gov (United States)

    Jo, Chanwoo; Bae, Doohwan; Choi, Byungho; Kim, Jihun

    2017-05-01

    Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery. This report describes 2 cases of removal of a mesiodens-1 from a child and 1 from an adolescent-using a surgical guide; these would have been difficult to remove with conventional surgical methods. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  11. Experience in the review of utility control room design review and safety parameter display system programs

    International Nuclear Information System (INIS)

    Moore, V.A.

    1985-01-01

    The Detailed Control Room Design Review (DCRDR) and the Safety Parameter Display System (SPDS) had their origins in the studies and investigations conducted as the result of the TMI-2 accident. The President's Commission (Kemeny Commission) critized NRC for not examining the man-machine interface, over-emphasizing equipment, ignoring human beings, and tolerating outdated technology in control rooms. The Commission's Special Inquiry Group (Rogovin Report) recommended greater application of human factors engineering including better instrumentation displays and improved control room design. The NRC Lessons Learned Task Force concluded that licensees should review and improve control rooms using NRC Human engineering guidelines, and install safety parameter display systems (then called the safety staff vector). The TMI Action Plan Item I.D.1 and I.D.2 were based on these recommendations

  12. A Parametric Geometry Computational Fluid Dynamics (CFD) Study Utilizing Design of Experiments (DOE)

    Science.gov (United States)

    Rhew, Ray D.; Parker, Peter A.

    2007-01-01

    Design of Experiments (DOE) was applied to the LAS geometric parameter study to efficiently identify and rank primary contributors to integrated drag over the vehicles ascent trajectory in an order of magnitude fewer CFD configurations thereby reducing computational resources and solution time. SME s were able to gain a better understanding on the underlying flowphysics of different geometric parameter configurations through the identification of interaction effects. An interaction effect, which describes how the effect of one factor changes with respect to the levels of other factors, is often the key to product optimization. A DOE approach emphasizes a sequential approach to learning through successive experimentation to continuously build on previous knowledge. These studies represent a starting point for expanded experimental activities that will eventually cover the entire design space of the vehicle and flight trajectory.

  13. Conceptual design of an integrated LLW treatment facility at a large utility

    International Nuclear Information System (INIS)

    Kohout, R.; Krochmalnek, L.S.; Mackie, A.

    1992-01-01

    Ontario Hydro's Waste Volume Reduction Facility (WVRF) has been providing centralized processing for the solid low level radioactive waste (LLW) generated at Ontario Hydro nuclear stations since 1977. The existing incineration and low force mechanical compaction processing equipment is now insufficient. Following intensive review of the possible options it was concluded that a major rebuilding of the WVRF would be required to meet the overall waste management requirements for the next 20 years. In 1991, Ontario Hydro completed a conceptual design of the new upgraded WVRF. The terms of reference for the design has been to achieve a state-of-the-art integrated waste management facility, which can handle all types and quantities (e.g. 9000 m 3 /year) of LLW, including organic liquid LLW, generated presently and in the future at Ontario Hydro. This design includes capability for gradual retrieval, processing and conditioning of the existing stored waste to meet long term waste form requirements. If approved by the corporation, the new facility is to include a replacement incineration system, a high force compaction system and a spectrum of auxiliary processes for waste pretreatment, including a state-of-the-art material handling system. (author)

  14. Computer utilization for design and operation of the SuperHILAC

    International Nuclear Information System (INIS)

    Selph, F.B.; Spence, D.A.

    1974-01-01

    The in-house constructed computer codes at the SuperHILAC can be divided into three main categories: (1) accelerator and component design; (2) control and operation; and (3) performance and diagnostics. The first category includes design programs of rf cavities, magnets, and beam optics. The second group contains programs for administration and logbook entries, machine parameter specifications, and openloop parameter control. Programs in the third category are those which directly or indirectly test the mechanical design and geometry of the machine, such as magnet testing, drift-tube-alignment, beam behavior and diagnostics. The present conversion of the SuperHILAC to computer control and a dual-ion time-sharing mode of operation is outlined in context with the complexities of operating this multi-ion, variable energy accelerator. Routines are discussed from the user's standpoint, covering such topics as on-line/off-line implementation, expected gain, actual results, and differences in characteristics which determine the method of computation. (U.S.)

  15. An Improved Fuzzy Logic Controller Design for PV Inverters Utilizing Differential Search Optimization

    Directory of Open Access Journals (Sweden)

    Ammar Hussein Mutlag

    2014-01-01

    Full Text Available This paper presents an adaptive fuzzy logic controller (FLC design technique for photovoltaic (PV inverters using differential search algorithm (DSA. This technique avoids the exhaustive traditional trial and error procedure in obtaining membership functions (MFs used in conventional FLCs. This technique is implemented during the inverter design phase by generating adaptive MFs based on the evaluation results of the objective function formulated by the DSA. In this work, the mean square error (MSE of the inverter output voltage is used as an objective function. The DSA optimizes the MFs such that the inverter provides the lowest MSE for output voltage and improves the performance of the PV inverter output in terms of amplitude and frequency. The design procedure and accuracy of the optimum FLC are illustrated and investigated using simulations conducted for a 3 kW three-phase inverter in a MATLAB/Simulink environment. Results show that the proposed controller can successfully obtain the desired output when different linear and nonlinear loads are connected to the system. Furthermore, the inverter has reasonably low steady state error and fast response to reference variation.

  16. Utility of a semi-scleral contact lens design in the management of the irregular cornea.

    Science.gov (United States)

    Romero-Jiménez, Miguel; Flores-Rodríguez, Patricia

    2013-06-01

    To evaluate the utility of the Rose K2 XL semi-scleral contact lens (Menicon Co. Ltd., Nagoya, Japan) in the management of the irregular cornea. Twenty-seven subjects (34 eyes) with irregular corneas referred for contact lens fitting were evaluated. A diagnostic trial set was used in the fitting process. Once the trial lens was considered optimal, a final lens was ordered from the manufacturer with the necessary changes in power, edge lift and diameter. We analyzed visual acuity, number of lenses ordered and patients' ability to wear and handle lenses. Twenty-three subjects (30 eyes) were fitted with the Rose K2 XL lens. Four subjects (4 eyes) decided not to conclude the fitting process for different reasons. Average logMAR visual acuity without correction and with the lens was 0.82 and 0.09, respectively (plenses (range 1-3) were necessary to achieve the optimal fit. Nineteen eyes (63%) were fitted with the first lens ordered. Three subjects (13%) had problems with lens handling, and three subjects (4 eyes) abandoned the wear of the lenses after three months due to discomfort (3 eyes) and unsatisfactory visual acuity (1 eye), respectively. Follow-up ranged from 6 to 9 months. Rose K2 XL semi-scleral contact lens provides good visual acuity and comfort in patients with irregular corneas. Copyright © 2012 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  17. Designing Effective Persuasive Systems Utilizing the Power of Entanglement: Communication Channel, Strategy and Affect

    Science.gov (United States)

    Li, Haiqing; Chatterjee, Samir

    With rapid advances in information and communication technology, computer-mediated communication (CMC) technologies are utilizing multiple IT platforms such as email, websites, cell-phones/PDAs, social networking sites, and gaming environments. However, no studies have compared the effectiveness of a persuasive system using such alternative channels and various persuasive techniques. Moreover, how affective computing impacts the effectiveness of persuasive systems is not clear. This study proposes (1) persuasive technology channels in combination with persuasive strategies will have different persuasive effectiveness; (2) Adding positive emotion to a message that leads to a better overall user experience could increase persuasive effectiveness. The affective computing or emotion information was added to the experiment using emoticons. The initial results of a pilot study show that computer-mediated communication channels along with various persuasive strategies can affect the persuasive effectiveness to varying degrees. These results also shows that adding a positive emoticon to a message leads to a better user experience which increases the overall persuasive effectiveness of a system.

  18. Drainage design on peat land and its utilization for fish culture

    Science.gov (United States)

    Tribowo, R. Ismu; Novianti, Fithria

    2017-11-01

    The utilization of drainage technique developed by Hooghoudt and Ernst since 1940 can be applied for lowering ground water surface. Water in the drainage canal is able to be used for fresh water fish culture. Horizon Layer of Homogeneous Peat Soil has a hydraulic conductivity as high as 4.5 meters per day. The distance between drainage canals is 118 meters. Drainage water debit for every 23,600 square meter of land is 23.76 liters per minute. Horizon Layer of Heterogeneous Peat Soil has a hydraulic conductivity of peat soil as first soil layer as high as 4.5 meters per day and a hydraulic conductivity of sandy loam as second soil layer as high as 0.8 meters per day. The distance between drainage canals is 329 meters. Drainage water debit for every 65,800 square meter of land is 66.25 liters per minute. When the pH of the water has reached 5 up till 6, then spreading the fish seed can be conducted. Some types of fish that have been introduced in the peat land water are Patin Siam (Pangasianodon hypophthalmus), Lele Dumbo (Clarias gariepinus) and Nila (Oreochromis niloticus). Furthermore, the introduced fish into the peat land water must have an economic value for the people who grow the fish.

  19. Chem-prep PZT 95/5 for neutron generator applicatios : powder preparation characterization utilizing design of experiments.

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood, Steven John; Rodman-Gonzales, Emily Diane; Voigt, James A.; Moore, Diana Lynn

    2003-07-01

    Niobium doped PZT 95/5 (lead zirconate-lead titanate) is the material used in voltage bars for all ferroelectric neutron generator power supplies. In June of 1999, the transfer and scale-up of the Sandia Process from Department 1846 to Department 14192 was initiated. The laboratory-scale process of 1.6 kg has been successfully scaled to a production batch quantity of 10 kg. This report documents efforts to characterize and optimize the production-scale process utilizing Design of Experiments methodology. Of the 34 factors identified in the powder preparation sub-process, 11 were initially selected for the screening design. Additional experiments and safety analysis subsequently reduced the screening design to six factors. Three of the six factors (Milling Time, Media Size, and Pyrolysis Air Flow) were identified as statistically significant for one or more responses and were further investigated through a full factorial interaction design. Analysis of the interaction design resulted in developing models for Powder Bulk Density, Powder Tap Density, and +20 Mesh Fraction. Subsequent batches validated the models. The initial baseline powder preparation conditions were modified, resulting in improved powder yield by significantly reducing the +20 mesh waste fraction. Response variation analysis indicated additional investigation of the powder preparation sub-process steps was necessary to identify and reduce the sources of variation to further optimize the process.

  20. Design and evaluation of noise suppression sheet for GHz band utilizing magneto-elastic effect

    Science.gov (United States)

    Igarashi, Toshiyuki; Kondo, Koichi; Yoshida, Shigeyoshi

    2017-12-01

    Feasibility of realizing a noise suppression sheet (NSS) coping with the low SHF band such as the 5 GHz band was investigated, which was composed of soft magnetic metal flakes dispersed in a polymer. For suppressing noises, the higher frequency one of the bimodal frequency dispersion (lower frequency one: Dispersion DII, higher frequency one: Dispersion DIII) seen in the imaginary permeability (μ″; magnetic loss component) spectrum of the NSS was aimed to utilize. Referring to the previous finding that Dispersion DIII is originated from a magneto-elastic effect, several magnetic composite sheets were prepared using various alloy flakes with different saturation magnetostriction (λs), and their frequency (fr(DIII)) and magnitude (μ″(DIII)) of Dispersion DIII were investigated. It was found that the NSS containing flakes with higher λs exhibited higher fr(DIII) and higher μ″(DIII)/μ″(DII), which was ratio of μ″(DIII) to the magnitude of Dispersion DII (μ″(DII)). The fr(DIII) for the NSS having the highest λs containing Fe-Co alloy flake reached 7.45 GHz and μ″ in the 5 GHz band was approximately twice as high as the conventional NSS containing Fe-Si-Al alloy flake. For transmission attenuation power ratio (Rtp) when an NSS was placed on a microstrip line with characteristic impedance of 50 Ω, NSS with larger fr(DIII)2 · μ″(DIII) ∝ Ms2 (Ms: saturation magnetization), which theoretically gave the frequency limit of imaginary permeability for a thin film, exhibited larger Rtp in the low SHF band. These results suggested that an NSS containing a magnetic flake material with both large λs and Ms was suitable for suppressing low SHF band noises.

  1. Bioreactor process parameter screening utilizing a Plackett-Burman design for a model monoclonal antibody.

    Science.gov (United States)

    Agarabi, Cyrus D; Schiel, John E; Lute, Scott C; Chavez, Brittany K; Boyne, Michael T; Brorson, Kurt A; Khan, Mansoora; Read, Erik K

    2015-06-01

    Consistent high-quality antibody yield is a key goal for cell culture bioprocessing. This endpoint is typically achieved in commercial settings through product and process engineering of bioreactor parameters during development. When the process is complex and not optimized, small changes in composition and control may yield a finished product of less desirable quality. Therefore, changes proposed to currently validated processes usually require justification and are reported to the US FDA for approval. Recently, design-of-experiments-based approaches have been explored to rapidly and efficiently achieve this goal of optimized yield with a better understanding of product and process variables that affect a product's critical quality attributes. Here, we present a laboratory-scale model culture where we apply a Plackett-Burman screening design to parallel cultures to study the main effects of 11 process variables. This exercise allowed us to determine the relative importance of these variables and identify the most important factors to be further optimized in order to control both desirable and undesirable glycan profiles. We found engineering changes relating to culture temperature and nonessential amino acid supplementation significantly impacted glycan profiles associated with fucosylation, β-galactosylation, and sialylation. All of these are important for monoclonal antibody product quality. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  2. Design method for multi-user workstations utilizing anthropometry and preference data.

    Science.gov (United States)

    Mahoney, Joseph M; Kurczewski, Nicolas A; Froede, Erick W

    2015-01-01

    Past efforts have been made to design single-user workstations to accommodate users' anthropometric and preference distributions. However, there is a lack of methods for designing workstations for group interaction. This paper introduces a method for sizing workstations to allow for a personal work area for each user and a shared space for adjacent users. We first create a virtual population with the same anthropometric and preference distributions as an intended demographic of college-aged students. Members of the virtual population are randomly paired to test if their extended reaches overlap but their normal reaches do not. This process is repeated in a Monte Carlo simulation to estimate the total percentage of groups in the population that will be accommodated for a workstation size. We apply our method to two test cases: in the first, we size polygonal workstations for two populations and, in the second, we dimension circular workstations for different group sizes. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  3. Heat Rejection Systems Utilizing Composites and Heat Pipes: Design and Performance Testing

    Science.gov (United States)

    Jaworske, Donald A.; Beach, Duane E.; Sanzi, James L.

    2007-01-01

    Polymer matrix composites offer the promise of reducing the mass and increasing the performance of future heat rejection systems. With lifetimes for heat rejection systems reaching a decade or more in a micrometeoroid environment, use of multiple heat pipes for fault tolerant design is compelling. The combination of polymer matrix composites and heat pipes is of particular interest for heat rejection systems operating on the lunar surface. A technology development effort is under way to study the performance of two radiator demonstration units manufactured with different polymer matrix composite face sheet resin and bonding adhesives, along with different titanium-water heat pipe designs. Common to the two radiator demonstration units is the use of high thermal conductivity fibers in the face sheets and high thermal conductivity graphite saddles within a light weight aluminum honeycomb core. Testing of the radiator demonstration units included thermal vacuum exposure and thermal vacuum exposure with a simulated heat pipe failure. Steady state performance data were obtained at different operating temperatures to identify heat transfer and thermal resistance characteristics. Heat pipe failure was simulated by removing the input power from an individual heat pipe in order to identify the diminished performance characteristics of the entire panel after a micrometeoroid strike. Freeze-thaw performance was also of interest. This paper presents a summary of the two radiator demonstration units manufactured to support this technology development effort along with the thermal performance characteristics obtained to date. Future work will also be discussed.

  4. A methodology for the sustainable design and implementation strategy of CO2 utilization processes

    DEFF Research Database (Denmark)

    Roh, Kosan; Frauzem, Rebecca; Nguyen, Tuan B. H.

    2016-01-01

    synthesis are considered. Methanol plants employing such methods are developed using synthesis-design and simulation tools and their evaluation indicators are calculated under various implementation strategies. It is demonstrated that integrating or replacing an existing conventional methanol plant...... design and analysis is discussed as only limited amounts of process data is available for determining the optimal processing path and in the third stage the issue of implementation strategy is considered. As examples, two CO2 utilization methods for methanol production, combined reforming and direct...... by a combined reforming method represents a sustainable solution. Additionally, producing methanol through direct hydrogenation is a promising way to convert CO2 when cheap H2 feeds are available....

  5. Efficient utilization of renewable feedstocks: the role of catalysis and process design

    Science.gov (United States)

    Palkovits, Regina; Delidovich, Irina

    2017-11-01

    Renewable carbon feedstocks such as biomass and CO2 present an important element of future circular economy. Especially biomass as highly functionalized feedstock provides manifold opportunities for the transformation into attractive platform chemicals. However, this change of the resources requires a paradigm shift in refinery design. Fossil feedstocks are processed in gas phase at elevated temperature. In contrast, biorefineries are based on processes in polar solvents at moderate conditions to selectively deoxygenate the polar, often thermally instable and high-boiling molecules. Here, challenges of catalytic deoxygenation, novel strategies for separation and opportunities provided at the interface to biotechnology are discussed in form of showcases. This article is part of a discussion meeting issue 'Providing sustainable catalytic solutions for a rapidly changing world'.

  6. Large round bale feeder design affects hay utilization and beef cow behavior.

    Science.gov (United States)

    Buskirk, D D; Zanella, A J; Harrigan, T M; Van Lente, J L; Gnagey, L M; Kaercher, M J

    2003-01-01

    One hundred sixty beef cows (631 +/- 78 kg) were used to evaluate the quantity of hay loss and feeding behaviors from different round bale feeders. Twenty cows were allotted by weight and body condition score to one of eight pens with four feeder designs: cone, ring, trailer, or cradle. All feeder types provided approximately 37 cm of linear feeder space per animal. Alfalfa and orchardgrass round bales were weighed and sampled before feeding. Hay that fell onto the concrete surrounding the feeder was considered waste and was collected and sampled daily. At the end of a 7-d period, each feeder type was assigned to a different pen for a second 7-d period. On four consecutive days in each period, animal behavior was recorded using a time-lapse video system. Data were collected from 5-min observational intervals from the video tapes every 0.5 h each day. Feeder access, occupancy rate, and occurrence of agonistic interactions were recorded. Dry matter hay waste was 3.5, 6.1, 11.4, and 14.6% for the cone, ring, trailer, and cradle feeders, respectively. Calculated dry matter intake of hay ranged from 1.8 to 2.0% of body weight and was not different among feeder type (P < 0.05). Percentage of organic matter, neutral detergent fiber, acid detergent fiber, and crude protein were all lower and acid detergent lignin was higher in the recovered waste compared to the hay fed (P < 0.05). Cows feeding from the cradle feeder had nearly three times the agonistic interactions and four times the frequency of entrances compared to cows feeding from the other feeder types (P < 0.05). Feed losses were positively correlated with agonistic interactions, frequency of regular and irregular entrances, and feeder occupancy rate (P < 0.05). Agonistic interactions by cows and frequency of feeder entrances differed among feeders and were correlated to feeder design induced feed losses.

  7. A Preliminary Modified Volumetric Mix Design for Self-Compacting Concrete (SCC by Utilizing Asphalt Dust Waste (ADW

    Directory of Open Access Journals (Sweden)

    Ismail Isham

    2017-01-01

    Full Text Available The construction of asphalt roads has been commonly used as for infrastructure development since ancient times. The production of asphalt using drum mix plants has created powder waste in the premix batching plant industry. It consists of very fine powders and causesproblems to the environment today. However, powder waste can be successfully and economically utilized in the development of self-compacting concrete (SCC. The aim of this study is to evaluate the fresh properties and the compressive strength of SCC containing asphalt dust waste (ADW. For this purpose, a simple modified volumetric mix design approach based on the Okumura Method was adapted to produce SCC mixes. In order to obtain this SCC, a series of SCC mixes with a specific water/binder ratio (0.3, superplasticizer ratio (2% as well as different amounts of aggregate, sand and ADW were prepared. Fresh properties of the SCC mix were tested using tests such as slump-flow, J-Ring, L-box and V-funnel which showed satisfactory results for MD840 and MD850. The compressive strength for MD840 and MD850 after 28 days was 40.8 MPa and 34.7 MPa respectively. In conclusion, the simple modified volumetric mix design method by utilizing ADW in SCC can be suggested for the development of SCC.

  8. Utilization of Minor Actinides as a Fuel Component for Ultra-Long Life Bhr Configurations: Designs, Advantages and Limitations

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Pavel V. Tsvetkov

    2009-05-20

    This project assessed the advantages and limitations of using minor actinides as a fuel component to achieve ultra-long life Very High Temperature Reactor (VHTR) configurations. Researchers considered and compared the capabilities of pebble-bed and prismatic core designs with advanced actinide fuels to achieve ultra-long operation without refueling. Since both core designs permit flexibility in component configuration, fuel utilization, and fuel management, it is possible to improve fissile properties of minor actinides by neutron spectrum shifting through configuration adjustments. The project studied advanced actinide fuels, which could reduce the long-term radio-toxicity and heat load of high-level waste sent to a geologic repository and enable recovery of the energy contained in spent fuel. The ultra-long core life autonomous approach may reduce the technical need for additional repositories and is capable to improve marketability of the Generation IV VHTR by allowing worldwide deployment, including remote regions and regions with limited industrial resources. Utilization of minor actinides in nuclear reactors facilitates developments of new fuel cycles towards sustainable nuclear energy scenarios.

  9. Utilization of Minor Actinides as a Fuel Component for Ultra-Long Life VHTR Configurations: Designs, Advantages and Limitations

    International Nuclear Information System (INIS)

    Tsvetkov, Pavel V.

    2009-01-01

    This project assessed the advantages and limitations of using minor actinides as a fuel component to achieve ultra-long life Very High Temperature Reactor (VHTR) configurations. Researchers considered and compared the capabilities of pebble-bed and prismatic core designs with advanced actinide fuels to achieve ultra-long operation without refueling. Since both core designs permit flexibility in component configuration, fuel utilization, and fuel management, it is possible to improve fissile properties of minor actinides by neutron spectrum shifting through configuration adjustments. The project studied advanced actinide fuels, which could reduce the long-term radio-toxicity and heat load of high-level waste sent to a geologic repository and enable recovery of the energy contained in spent fuel. The ultra-long core life autonomous approach may reduce the technical need for additional repositories and is capable to improve marketability of the Generation IV VHTR by allowing worldwide deployment, including remote regions and regions with limited industrial resources. Utilization of minor actinides in nuclear reactors facilitates developments of new fuel cycles towards sustainable nuclear energy scenarios.

  10. NRC review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Evolutionary plant designs, Chapter 1, Project No. 669

    International Nuclear Information System (INIS)

    1992-08-01

    The staff of the US Nuclear Regulatory Commission has prepared Volume 2 (Parts 1 and 2) of a safety evaluation report (SER), ''NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Evolutionary Plant Designs,'' to document the results of its review of the Electric Power Research Institute's ''Advanced Light Water Reactor Utility Requirements Document.'' This SER gives the results of the staff's review of Volume II of the Requirements Document for evolutionary plant designs, which consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant (approximately 1300 megawatts-electric)

  11. NRC review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Evolutionary plant designs, Chapters 2--13, Project No. 669

    International Nuclear Information System (INIS)

    1992-08-01

    The staff of the US Nuclear Regulatory Commission has prepared Volume 2 (Parts 1 and 2) of a safety evaluation report (SER), ''NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Evolutionary Plant Designs,'' to document the results of its review of the Electric Power Research Institute's ''Advanced Light Water Reactor Utility Requirements Document.'' This SER gives the results of the staff's review of Volume II of the Requirements Document for evolutionary plant designs, which consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant (approximately 1300 megawatts-electric)

  12. Enhancement of knowledge construction activities utilizing 21st century learning design rubric

    Science.gov (United States)

    Pedoche, Margarette Anne U.; Taladua, Janica Mae M.; Panal, Geicky Pearl C.; Magsayo, Joy R.; Guarin, Rica Mae B.; Myrna, H. Lahoylahoy

    2018-01-01

    The main objective of the study was to enhance knowledge construction activities on its design particularly the objectives, support materials, student activities and assessment tools. Activities from the 2nd Quarter of Science Learners Material were the basis in the adaptation of activities. The adapted activities were evaluated by the In-service Science teachers and undergone modification by the researchers based on the teacher's comments and suggestions. It was then evaluated, revised, and validated, tried-out using the 21st CLD Rubric. Subjects of the study were 110 students from Grade 7-B, Grade 7-D, Grade 7-F in Geronima Cabrera National High School, Kolambugan, Lanao del Norte during the academic year 2016-2017, the study to determine their learning capabilities investigated by the use of Knowledge Construction Activities in the 21st Century Classroom, to investigate how the lessons were understood and appreciated by students, to stimulate interpretation, analysis, synthesizing, or evaluating ideas and develop critical thinking. Both quantitative and qualitative data were obtained from the students' scores in three activities. Results showed that there was a significant difference between the pretest and posttest scores of students. Mean scores between the pretest and posttest showed a mean difference of 3.35, thus the null hypothesis was rejected. It could be concluded with sufficient evidence to show that the students had basically low prior knowledge about the topic ecosystem. A significant difference was seen in the pretest and posttest, scores of the activities and Ecosystem model results after the implementation phase that a knowledge construction type of activity was better than the traditional one for it promoted meaningful learning and active engagement of students. Based on the results, it was clear that the use of knowledge construction activities had an effect on student's achievement in comparison to traditional teaching method. Thus, it was

  13. Utilizing Iron's Attractive Chemical and Magnetic Properties in Microrocket Design, Extended Motion, and Unique Performance.

    Science.gov (United States)

    Karshalev, Emil; Chen, Chuanrui; Marolt, Gregor; Martín, Aída; Campos, Isaac; Castillo, Roxanne; Wu, Tianlong; Wang, Joseph

    2017-06-01

    All-in-one material for microrocket propulsion featuring acid-based bubble generation and magnetic guidance is presented. Electrochemically deposited iron serves as both a propellant, toward highly efficient self-propulsion in acidic environments, and as a magnetic component enabling complete motion control. The new microrockets display longer lifetime and higher propulsion efficiency compared to previously reported active metal zinc-based microrockets due to the chemical properties of iron and the unique structure of the microrockets. These iron-based microrockets also demonstrate unique and attractive cargo towing and autonomous release capabilities. The latter is realized upon loss of the magnetic properties due to acid-driven iron dissolution. More interestingly, these bubble-propelled microrockets assemble via magnetic interactions into a variety of complex configurations and train structures, which enrich the behavior of micromachines. Modeling of the magnetic forces during the microrocket assembly and cargo capture confirms these unique experimentally observed assembly and cargo-towing behaviors. These findings provide a new concept of blending propellant and magnetic components into one, toward simplifying the design and fabrication of artificial micro/nanomachines, realizing new functions and capabilities for a variety of future applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. 02A. Design, Methods, and Outcomes for Recent Clinical Trials Utilizing Ayurvedic Medicine, Yoga, and Meditation

    Science.gov (United States)

    Saper, Robert; Vinjamury, Sivarama; Elder, Charles

    2013-01-01

    Focus Area: Integrative Approaches to Care The panel discussants will present on the outcomes of four recent pragmatic trials covering the spectrum of Ayurvedic medicine, yoga, and meditation as therapeutic approaches for both acute and chronic conditions. The presenters will discuss: (1) a pilot study of a whole-systems Ayurveda and Yoga Therapy intervention for obesity; (2) a comparative effectiveness randomized controlled trial of hatha yoga, physical therapy, and education for non-specific chronic low back pain in low-income minority populations; (3) an investigation of the therapeutic usefulness of Shirodhara (Ayurvedic oil dripping therapy) as a treatment for insomnia; and (4) a discussion of the evidence base supporting implementation of meditation interventions in schools and workplace settings. Discussants will present information on study designs, research methodology, and outcome measure selection to highlight special considerations in conducting research on whole medical systems that use multi-target therapies and focus on patient-centered outcomes. Ayurvedic medicine and yoga are characterized by low-cost, noninvasive interventions that can be usefully offered as part of an integrative medicine therapeutic approach.

  15. The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.

    Science.gov (United States)

    Iacono, William G; Heath, Andrew C; Hewitt, John K; Neale, Michael C; Banich, Marie T; Luciana, Monica M; Madden, Pamela A; Barch, Deanna M; Bjork, James M

    2017-09-12

    The ABCD twin study will elucidate the genetic and environmental contributions to a wide range of mental and physical health outcomes in children, including substance use, brain and behavioral development, and their interrelationship. Comparisons within and between monozygotic and dizygotic twin pairs, further powered by multiple assessments, provide information about genetic and environmental contributions to developmental associations, and enable stronger tests of causal hypotheses, than do comparisons involving unrelated children. Thus a sub-study of 800 pairs of same-sex twins was embedded within the overall Adolescent Brain and Cognitive Development (ABCD) design. The ABCD Twin Hub comprises four leading centers for twin research in Minnesota, Colorado, Virginia, and Missouri. Each site is enrolling 200 twin pairs, as well as singletons. The twins are recruited from registries of all twin births in each State during 2006-2008. Singletons at each site are recruited following the same school-based procedures as the rest of the ABCD study. This paper describes the background and rationale for the ABCD twin study, the ascertainment of twin pairs and implementation strategy at each site, and the details of the proposed analytic strategies to quantify genetic and environmental influences and test hypotheses critical to the aims of the ABCD study. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. DC Thermal Plasma Design and Utilization for the Low Density Polyethylene to Diesel Oil Pyrolysis Reaction

    Directory of Open Access Journals (Sweden)

    Hossam A. Gabbar

    2017-06-01

    Full Text Available The exponential increase of plastic production produces 100 million tonnes of waste plastics annually which could be converted into hydrocarbon fuels in a thermal cracking process called pyrolysis. In this research work, a direct current (DC thermal plasma circuit is designed and used for conversion of low density polyethylene (LDPE into diesel oil in a laboratory scale pyrolysis reactor. The experimental setup uses a 270 W DC thermal plasma at operating temperatures in the range of 625 °C to 860 °C for a low density polyethylene (LDPE pyrolysis reaction at pressure = −0.95, temperature = 550 °C with τ = 30 min at a constant heating rate of 7.8 °C/min. The experimental setup consists of a vacuum pump, closed system vessel, direct current (DC plasma circuit, and a k-type thermocouple placed a few millimeters from the reactant sample. The hydrocarbon products are condensed to diesel oil and analyzed using flame ionization detector (FID gas chromatography. The analysis shows 87.5% diesel oil, 1,4-dichlorobenzene (Surr, benzene, ethylbenzene and traces of toluene and xylene. The direct current (DC thermal plasma achieves 56.9 wt. % of diesel range oil (DRO, 37.8 wt. % gaseous products and minimal tar production. The direct current (DC thermal plasma shows reliability, better temperature control, and high thermal performance as well as the ability to work for long operation periods.

  17. Utilizing Bloom's taxonomy to design a substance use disorders course for health professions students.

    Science.gov (United States)

    Muzyk, Andrew J; Tew, Chris; Thomas-Fannin, Allie; Dayal, Sanjai; Maeda, Reina; Schramm-Sapyta, Nicole; Andolsek, Kathryn; Holmer, Shelley

    2018-02-05

    each of the 3 domains in Bloom's taxonomy. The authors believe their course design may serve as a framework for future SUDs courses.

  18. Design Optimization of an Electromagnetic Energy Harvester Backpack for Utilization of Human Walking Energy

    Science.gov (United States)

    Mullen, Christopher

    Implementation of energy harvesting technology can provide a sustainable, remote power source for soldiers by reducing the battery weight and allowing them to stay in the field for longer periods of time. Among multiple energy conversion principles, electromagnetic induction can scavenge energy from wasted kinematic and vibration energy found from human motion. Hip displacement during human gait acts as a base excitation for an energy harvesting backpack system. The placement of a permanent magnet in this vibration environment results in relative motion of the magnet to the coil of copper wire, which induces an electric current. This current can be saved to a battery or capacitor bank installed on the backpack to be used to power electronic devices. The purpose of this research is to construct a reliable simulation model for an electromagnetic vibration energy harvester and use it for a multi-variable optimization algorithm to identify an optimal coil and magnet layout for highest power output. Key components of the coupled equations of motion such as the magnetic flux density and coil inductance are obtained using ANSYS multi-physics software or by measuring them. These components are fed into a harvester simulation model (e.g. coupled field equations of motion for the backpack harvester) that generates the electrical power output. The developed simulation model is verified with multiple case studies including an experimental test. Then the optimal design parameters in the simulation model (e.g., magnet layout, coil width, outer coil diameter, external load resistance) are identified for maximum power. Results from this study will pave the way for a more efficient energy harvesting backpack while providing better insight into the efficiency of magnet and coil layout for electromagnetic applications.

  19. Utility of Social Cognitive Theory in Intervention Design for Promoting Physical Activity among African-American Women: A Qualitative Study.

    Science.gov (United States)

    Joseph, Rodney P; Ainsworth, Barbara E; Mathis, LaTanya; Hooker, Steven P; Keller, Colleen

    2017-09-01

    We examined the cultural relevance of Social Cognitive Theory (SCT) in the design of a physical activity intervention for African-American women. A qualitative study design was used. Twenty-five African-American women (Mean age = 38.5 years, Mean BMI = 39.4 kg·m2) were enrolled in a series of focus groups (N = 9) to elucidate how 5 SCT constructs (ie, Behavioral Capability, Outcome Expectations, Self-efficacy, Self-regulation, Social Support) can be culturally tailored in the design of a physical activity program for African-American women. For the construct of Behavioral Capability, participants were generally unaware of the amount, intensity, and types of physical activity needed for health benefits. Outcome Expectations associated with physical activity included increased energy, improved health, weight loss, and positive role modeling behaviors. Constructs of Self-efficacy and Self-regulation were elicited through the women perceiving themselves as a primary barrier to physical activity. Participants endorsed the need of a strong social support component and identified a variety of acceptable sources to include in a physical activity program (ie, family, friends, other program participants). Findings explicate the utility of SCT as a behavioral change theoretical basis for tailoring physical activity programs to African-American women.

  20. Compressed air energy storage: preliminary design and site development program in an aquifer. Final draft, Task 1: establish facility design criteria and utility benefits

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    Compressed air energy storage (CAES) has been identified as one of the principal new energy storage technologies worthy of further research and development. The CAES system stores mechanical energy in the form of compressed air during off-peak hours, using power supplied by a large, high-efficiency baseload power plant. At times of high electrical demand, the compressed air is drawn from storage and is heated in a combustor by the burning of fuel oil, after which the air is expanded in a turbine. In this manner, essentially all of the turbine output can be applied to the generation of electricity, unlike a conventional gas turbine which expends approximately two-thirds of the turbine shaft power in driving the air compressor. The separation of the compression and generation modes in the CAES system results in increased net generation and greater premium fuel economy. The use of CAES systems to meet the utilities' high electrical demand requirements is particularly attractive in view of the reduced availability of premium fuels such as oil and natural gas. This volume documents the Task 1 work performed in establishing facility design criteria for a CAES system with aquifer storage. Information is included on: determination of initial design bases; preliminary analysis of the CAES system; development of data for site-specific analysis of the CAES system; detailed analysis of the CAES system for three selected heat cycles; CAES power plant design; and an economic analysis of CAES.

  1. CONCEPTUAL DESIGN FOR A RADICALLY SMALLER, HIGHLY ADAPTIVE AND APPLICATION-FLEXIBLE MINING MACHINE FOR UTILITY AND DEVELOPMENT WORK

    Energy Technology Data Exchange (ETDEWEB)

    Andrew H. Stern

    2004-12-20

    The aim of this research project was to develop a preliminary ''conceptual design'' for a radically smaller, highly adaptive and application-flexible underground coal mining machine, for performing non-production utility work and/or also undertake limited production mining for the recovery of reserves that would otherwise be lost. Whereas historically, mining philosophies have reflected a shift to increasing larger mechanized systems [such as the continuous miner (CM)], specific mining operations that do not benefit from the economy of the large mining equipment are often ignored or addressed with significant inefficiencies. Developing this prototype concept will create a new class of equipment that can provide opportunities to re-think the very structure of the mining system across a broad range of possibilities, not able to be met by existing machinery. The approach involved pooling the collective input from mining professionals, using a structured listing of desired inputs in the form of a questionnaire, which was used to define the range of desired design specifications. From these inputs, a conceptual specification was blended, by the author, to embody the general concurrence of mission concepts for this machine.

  2. The Credibility Revolution in Empirical Economics: How Better Research Design is Taking the Con out of Econometrics. NBER Working Paper No. 15794

    Science.gov (United States)

    Angrist, Joshua; Pischke, Jorn-Steffen

    2010-01-01

    This essay reviews progress in empirical economics since Leamer'rs (1983) critique. Leamer highlighted the benefits of sensitivity analysis, a procedure in which researchers show how their results change with changes in specification or functional form. Sensitivity analysis has had a salutary but not a revolutionary effect on econometric practice.…

  3. Extension of the hybrid linear programming method to optimize simultaneously the design and operation of groundwater utilization systems

    Science.gov (United States)

    Bostan, Mohamad; Hadi Afshar, Mohamad; Khadem, Majed

    2015-04-01

    This article proposes a hybrid linear programming (LP-LP) methodology for the simultaneous optimal design and operation of groundwater utilization systems. The proposed model is an extension of an earlier LP-LP model proposed by the authors for the optimal operation of a set of existing wells. The proposed model can be used to optimally determine the number, configuration and pumping rates of the operational wells out of potential wells with fixed locations to minimize the total cost of utilizing a two-dimensional confined aquifer under steady-state flow conditions. The model is able to take into account the well installation, piping and pump installation costs in addition to the operational costs, including the cost of energy and maintenance. The solution to the problem is defined by well locations and their pumping rates, minimizing the total cost while satisfying a downstream demand, lower/upper bound on the pumping rates, and lower/upper bound on the water level drawdown at the wells. A discretized version of the differential equation governing the flow is first embedded into the model formulation as a set of additional constraints. The resulting mixed-integer highly constrained nonlinear optimization problem is then decomposed into two subproblems with different sets of decision variables, one with a piezometric head and the other with the operational well locations and the corresponding pumping rates. The binary variables representing the well locations are approximated by a continuous variable leading to two LP subproblems. Having started with a random value for all decision variables, the two subproblems are solved iteratively until convergence is achieved. The performance and ability of the proposed method are tested against a hypothetical problem from the literature and the results are presented and compared with those obtained using a mixed-integer nonlinear programming method. The results show the efficiency and effectiveness of the proposed method for

  4. The effect of mass vaccination campaigns against polio on the utilization of routine immunization services: A regression discontinuity design.

    Science.gov (United States)

    Helleringer, Stephane; Asuming, Patrick O; Abdelwahab, Jalaa

    2016-07-19

    In most low and middle-income countries (LMIC), vaccines are primarily distributed by routine immunization services (RI) at health facilities. Additional opportunities for vaccination are also provided through mass vaccination campaigns, conducted periodically as part of disease-specific initiatives. It is unclear whether these campaigns are detrimental to RI services, or wether they may stimulate the utilization of RI. Unobserved confounders and reverse causality have limited existing evaluations of the effects of mass vaccination campaigns on RI services. We explored the use of a regression discontinuity design (RDD) to measure these effects more precisely. This is a quasi-experimental method, which exploits random variations in birth dates to identify the causal effects of vaccination campaigns. We applied RDD to survey data on a nationwide vaccination campaign against Polio conducted in Bangladesh. We compared systematically the children born immediately before vs. after the vaccination campaign. These two groups had similar background characteristics, but differed by their exposure to the vaccination campaign. Contrary to previous studies, exposure to the campaign had positive effects on RI utilization. Children exposed to the campaign received between 0.296 and 0.469 additional doses of DPT vaccine by age 4months than unexposed children. RDD constitutes a promising tool to assess the effects of mass vaccination campaigns on RI services. It could be tested in additional settings, using larger and more precise datasets. It could also be extended to measure the effects of other disease-specific interventions on the functioning of health systems, in particular those that occur at a discrete point in time and/or include age-related eligibility criteria. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. A decision support system framework to improve design-construction integration and project performance on public sector underground utility projects

    Science.gov (United States)

    Gehrig, Gary Bruce

    ultimate decision made. The framework for the decision support system was evaluated by knowledgeable industry sources and through the use of a hypothetical case study. Evaluations determined the proposed system would improve design and construction integration and project performance on public sector underground utility projects. However, additional research is required into determining both the most suitable lessons-learned database structure and ways to increase the incentive for project participants to fully participate in the methodology.

  6. Empirically Testing Thematic Analysis (ETTA)

    DEFF Research Database (Denmark)

    Alkier Gildberg, Frederik; Bradley, Stephen; Tingleff, Ellen Boldrup

    2015-01-01

    Text analysis is not a question of a right or wrong way to go about it, but a question of different traditions. These tend to not only give answers to how to conduct an analysis, but also to provide the answer as to why it is conducted in the way that it is. The problem however may be that the li....../develop for themselves. The advantage of utilizing the presented analytic approach is argued to be the integral empirical testing, which should assure systematic development, interpretation and analysis of the source textual material....... between tradition and tool is unclear. The main objective of this article is therefore to present Empirical Testing Thematic Analysis, a step by step approach to thematic text analysis; discussing strengths and weaknesses, so that others might assess its potential as an approach that they might utilize...

  7. NRC review of Electric Power Research Institute's advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    International Nuclear Information System (INIS)

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the open-quotes Advanced Light Water Reactor [ALWR] Utility Requirements Documentclose quotes, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, open-quotes ALWR Policy and Summary of Top-Tier Requirementsclose quotes, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, open-quotes NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Program Summaryclose quotes, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review

  8. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapter 1, project number 669

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume 1, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  9. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  10. NRC review of Electric Power Research Institute's advanced light water reactor utility requirements document. Passive plant designs, chapter 1, project number 669

    International Nuclear Information System (INIS)

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the open-quotes Advanced Light Water Reactor [ALWR] Utility Requirements Documentclose quotes, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume 1, open-quotes ALWR Policy and Summary of Top-Tier Requirementsclose quotes, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, open-quotes NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Program Summaryclose quotes, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review

  11. Design Paradigm Utilizing Reversible Diels-Alder Reactions to Enhance the Mechanical Properties of 3D Printed Materials.

    Science.gov (United States)

    Davidson, Joshua R; Appuhamillage, Gayan A; Thompson, Christina M; Voit, Walter; Smaldone, Ronald A

    2016-07-06

    A design paradigm is demonstrated that enables new functional 3D printed materials made by fused filament fabrication (FFF) utilizing a thermally reversible dynamic covalent Diels-Alder reaction to dramatically improve both strength and toughness via self-healing mechanisms. To achieve this, we used as a mending agent a partially cross-linked terpolymer consisting of furan-maleimide Diels-Alder (fmDA) adducts that exhibit reversibility at temperatures typically used for FFF printing. When this mending agent is blended with commercially available polylactic acid (PLA) and printed, the resulting materials demonstrate an increase in the interfilament adhesion strength along the z-axis of up to 130%, with ultimate tensile strength increasing from 10 MPa in neat PLA to 24 MPa in fmDA-enhanced PLA. Toughness in the z-axis aligned prints increases by up to 460% from 0.05 MJ/m(3) for unmodified PLA to 0.28 MJ/m(3) for the remendable PLA. Importantly, it is demonstrated that a thermally reversible cross-linking paradigm based on the furan-maleimide Diels-Alder (fmDA) reaction can be more broadly applied to engineer property enhancements and remending abilities to a host of other 3D printable materials with superior mechanical properties.

  12. Enhancing mindful coordination in fragmented utility construction practices: by developing, implementing and evaluating virtual design and construction models

    NARCIS (Netherlands)

    olde Scholtenhuis, Léon Luc

    2015-01-01

    Municipalities cope with a growth in number of utility network owners and subsurface network size. Simultaneously, the multiple utility owners involved in subsurface construction work need to align plans to cope with tight deadlines and imposed spatial constraints. This research hones in on this

  13. An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling

    DEFF Research Database (Denmark)

    Lyck, L.; Santamaria, I.D.; Pakkenberg, B.

    2009-01-01

    Improving histomorphometric analysis of the human neocortex by combining stereological cell counting with immunchistochemical visualisation of specific neuronal and glial cell populations is a methodological challenge. To enable standardized immunohistochemical staining, the amount of brain tissue...... at each level of sampling was determined empirically. The methodology was tested in three brains analysing the contribution of the multi-step sampling procedure to the precision on the estimated total numbers of immunohistochemically defined NeuN expressing (NeuN(+)) neurons and CD45(+) microglia...

  14. An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling

    DEFF Research Database (Denmark)

    Lyck, Lise; Santamaria, Ishar Dalmau; Pakkenberg, Bente

    2009-01-01

    Improving histomorphometric analysis of the human neocortex by combining stereological cell counting with immunohistochemical visualisation of specific neuronal and glial cell populations is a methodological challenge. To enable standardized immunohistochemical staining, the amount of brain tissue...... at each level of sampling was determined empirically. The methodology was tested in three brains analysing the contribution of the multi-step sampling procedure to the precision on the estimated total numbers of immunohistochemically defined NeuN expressing (NeuN(+)) neurons and CD45(+) microglia...

  15. Design and Implementation of a Unified Command and Control Architecture for Multiple Cooperative Unmanned Vehicles Utilizing Commercial Off the Shelf Components

    Science.gov (United States)

    2015-12-24

    2 COTS Commercial Off the Shelf . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 UAV Unmanned...DESIGN AND IMPLEMENTATION OF A UNIFIED COMMAND AND CONTROL ARCHITECTURE FOR MULTIPLE COOPERATIVE UNMANNED VEHICLES UTILIZING COMMERCIAL OFF THE SHELF... COMMERCIAL OFF THE SHELF COMPONENTS THESIS Presented to the Faculty Department of Systems Engineering and Management Graduate School of Engineering and

  16. Streamlining and integrating right-of-way and utility processes with planning, environmental, and design processes in Australia and Canada.

    Science.gov (United States)

    2009-06-01

    Many transportation projects require acquisition of land and accommodation of utility facilities in the : right-of-way. The Federal Highway Administration, American Association of State Highway and : Transportation Officials, and National Cooperative...

  17. Sustainable process design with process intensification - Development and implementation of a framework for sustainable carbon dioxide capture and utilization processes

    DEFF Research Database (Denmark)

    Frauzem, Rebecca

    Due to environmental concerns, greenhouse gas emissions, particularly carbon dioxide, need to be reduced. There are numerous methods being discussed, one of which is carbon dioxide capture and utilization (CCU). Carbon dioxide capture and utilization removes the carbon dioxide from the offgas...... hydrogenation. Through the analysis of the processes, it can be seen that the methanol distillation and the dimethyl carbonate downstream separation contribute to largeamounts of the utility consumption and therefore costs. Therefore, the reductionof the utility consumption of the methanol distillation...... and dimethyl carbonate downstream process are targeted for improvement. In Stage 3, the targets are addressed by introducing a hybrid distillation-membrane process and an intensified,reactive distillation dimethyl carbonate process. The result is four improved, more sustainable processes for the production...

  18. Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

    Directory of Open Access Journals (Sweden)

    Michael Pearce

    2018-02-01

    Full Text Available Abstract Background Most confirmatory randomised controlled clinical trials (RCTs are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided test. Approval of the experimental treatment by regulatory agencies is then based on the result of such a significance test with other information to balance the risk of adverse events against the benefit of the treatment to future patients. In the setting of a rare disease, recruiting sufficient patients to achieve conventional error rates for clinically reasonable effect sizes may be infeasible, suggesting that the decision-making process should reflect the size of the target population. Methods We considered the use of a decision-theoretic value of information (VOI method to obtain the optimal sample size and significance level for confirmatory RCTs in a range of settings. We assume the decision maker represents society. For simplicity we assume the primary endpoint to be normally distributed with unknown mean following some normal prior distribution representing information on the anticipated effectiveness of the therapy available before the trial. The method is illustrated by an application in an RCT in haemophilia A. We explicitly specify the utility in terms of improvement in primary outcome and compare this with the costs of treating patients, both financial and in terms of potential harm, during the trial and in the future. Results The optimal sample size for the clinical trial decreases as the size of the population decreases. For non-zero cost of treating future patients, either monetary or in terms of potential harmful effects, stronger evidence is required for approval as the population size increases, though this is not the case if the costs of treating future patients are ignored. Conclusions Decision-theoretic VOI methods offer a flexible approach with both type I error rate and power (or equivalently

  19. Value of information methods to design a clinical trial in a small population to optimise a health economic utility function.

    Science.gov (United States)

    Pearce, Michael; Hee, Siew Wan; Madan, Jason; Posch, Martin; Day, Simon; Miller, Frank; Zohar, Sarah; Stallard, Nigel

    2018-02-08

    Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided test. Approval of the experimental treatment by regulatory agencies is then based on the result of such a significance test with other information to balance the risk of adverse events against the benefit of the treatment to future patients. In the setting of a rare disease, recruiting sufficient patients to achieve conventional error rates for clinically reasonable effect sizes may be infeasible, suggesting that the decision-making process should reflect the size of the target population. We considered the use of a decision-theoretic value of information (VOI) method to obtain the optimal sample size and significance level for confirmatory RCTs in a range of settings. We assume the decision maker represents society. For simplicity we assume the primary endpoint to be normally distributed with unknown mean following some normal prior distribution representing information on the anticipated effectiveness of the therapy available before the trial. The method is illustrated by an application in an RCT in haemophilia A. We explicitly specify the utility in terms of improvement in primary outcome and compare this with the costs of treating patients, both financial and in terms of potential harm, during the trial and in the future. The optimal sample size for the clinical trial decreases as the size of the population decreases. For non-zero cost of treating future patients, either monetary or in terms of potential harmful effects, stronger evidence is required for approval as the population size increases, though this is not the case if the costs of treating future patients are ignored. Decision-theoretic VOI methods offer a flexible approach with both type I error rate and power (or equivalently trial sample size) depending on the size of the future population for

  20. Biomass to Hydrogen Production Detailed Design and Economics Utilizing the Battelle Columbus Laboratory Indirectly-Heated Gasifier

    Energy Technology Data Exchange (ETDEWEB)

    Spath, P.; Aden, A.; Eggeman, T.; Ringer, M.; Wallace, B.; Jechura, J.

    2005-05-01

    This analysis developed detailed process flow diagrams and an Aspen Plus{reg_sign} model, evaluated energy flows including a pinch analysis, obtained process equipment and operating costs, and performed an economic evaluation of two process designs based on the syngas clean up and conditioning work being performed at NREL. One design, the current design, attempts to define today's state of the technology. The other design, the goal design, is a target design that attempts to show the effect of meeting specific research goals.

  1. Integrated management model. Methodology and software-enabled tood designed to assist a utility in developing a station-wide optimization

    International Nuclear Information System (INIS)

    Llovet, R.; Ibanez, R.; Woodcock, J.

    2005-01-01

    A key concern for utilities today is optimizing station aging and realibility management activities in a manner that maximizes the value of those activities withing an affordable budget. The Westinghouse Proactive Asset Management Model is a methodology and software-enabled tood designed to assist a utility in developing a station-wide optimization of those activities. The process and tool support the development of an optimized, station-wide plan for inspection, testing, maintenance, repaor and replacement of aging components. The optimization identifies the benefit and optimal timing of those activities based on minimizing unplanned outage costs (avoided costs) and maximizing station Net Present Value. (Author)

  2. Argumentation and Reasoning in Design: An Empirical Analysis of the Effects of Verbal Reasoning on Idea Value in Group Idea Generation

    DEFF Research Database (Denmark)

    Cramer-Petersen, Claus L.; Ahmed-Kristensen, Saeema

    2016-01-01

    Reasoning is argumentative and is at the core of design activity and thinking. Understanding the influence of reasoning on the value of ideas is key to support design practice. The paper aims to show the effect of verbal reasoning on the value of ideas. Protocol analyses of four industry cases...

  3. Design of conveyor utilization monitoring system: a case study of powder coating line in sheet metal fabrication

    Science.gov (United States)

    Prasetyo, Hoedi; Sugiarto, Yohanes; Nur Rosyidi, Cucuk

    2018-03-01

    Conveyor is a very useful equipment to replace manpower in transporting the goods. It highly influences the productivity, production capacity utilization and eventually the production cost. This paper proposes a system to monitor the utilization of conveyor at a low cost through a case study at powder coating process line in a sheet metal fabrication. Preliminary observation was conducted to identify the problems. The monitoring system was then built and executed. The system consists of two sub systems. First is sub system for collecting and transmitting the required data and the second is sub system for displaying the data. The system utilizes sensors, wireless data transfer and windows-based application. The test results showed that the whole system works properly. By this system, the productivity and status of the conveyor can be monitored in real time. This research enriches the development of conveyor monitoring system especially for implementation in small and medium enterprises.

  4. Conceptual design of thermal energy storage systems for near term electric utility applications. Volume 1: Screening of concepts

    Science.gov (United States)

    Hausz, W.; Berkowitz, B. J.; Hare, R. C.

    1978-01-01

    Over forty thermal energy storage (TES) concepts gathered from the literature and personal contacts were studied for their suitability for the electric utility application of storing energy off-peak discharge during peak hours. Twelve selections were derived from the concepts for screening; they used as storage media high temperature water (HTW), hot oil, molten salts, and packed beds of solids such as rock. HTW required pressure containment by prestressed cast-iron or concrete vessels, or lined underground cavities. Both steam generation from storage and feedwater heating from storage were studied. Four choices were made for further study during the project. Economic comparison by electric utility standard cost practices, and near-term availability (low technical risk) were principal criteria but suitability for utility use, conservation potential, and environmental hazards were considered.

  5. Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. I....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases....

  6. Application of a computer-aided framework for the design of CO2 capture and utilization processes

    DEFF Research Database (Denmark)

    Frauzem, Rebecca; Gani, Rafiqul

    , and (3) innovation, has been developed. In order to facilitate the implementation and ensure sustainability, this framework integrates a number of computer-aided methods and tools, that are important for carbon dioxide capture and utilization. Applying this framework helps to address the questions about...... of carbon dioxide capture and utilization processes from coal-fired power plant flue gas to produce various value-added chemical products, including methanol, dimethyl carbonate, dimethyl ether, succinic acid and acetic acid, via conversion. First, the processing route is selected from a network...

  7. Investigation of storage system designs and techniques for optimizing energy conservation in integrated utility systems. Volume 1: (Executive summary)

    Science.gov (United States)

    1976-01-01

    Integrated Utility Systems (IUS) have been suggested as a means of reducing the cost and conserving the nonrenewable energy resources required to supply utility services (energy, water, and waste disposal) to developments of limited size. The potential for further improving the performance and reducing the cost of IUS installations through the use of energy storage devices is examined and the results are summarized. Candidate energy storage concepts in the general areas of thermal, inertial, superconducting magnetic, electrochemical, chemical, and compressed air energy storage are assessed and the storage of thermal energy as the sensible heat of water is selected as the primary candidate for near term application to IUS.

  8. Institutional Design and Utilization of Evaluation: A Contribution to a Theory of Evaluation Influence Based on Swiss Experience

    Science.gov (United States)

    Balthasar, Andreas

    2009-01-01

    Growing interest in the institutionalization of evaluation in the public administration raises the question as to which institutional arrangement offers optimal conditions for the utilization of evaluations. "Institutional arrangement" denotes the formal organization of processes and competencies, together with procedural rules, that are…

  9. Development of a catalog of resilient modulus values for aggregate base for use with the mechanistic-empirical pavement design guide (MEPDG).

    Science.gov (United States)

    2015-06-01

    Base aggregate is one of the intermediate layers in a pavement system for both flexible and rigid surfaces. Characterization : of base aggregate is necessary for pavement thickness design. Many transportation agencies, including the Virginia Departme...

  10. Using EPA Tools and Data Services to Inform Changes to Design Storm Definitions for Wastewater Utilities based on Climate Model Projections

    Science.gov (United States)

    Tryby, M.; Fries, J. S.; Baranowski, C.

    2014-12-01

    Extreme precipitation events can cause significant impacts to drinking water and wastewater utilities, including facility damage, water quality impacts, service interruptions and potential risks to human health and the environment due to localized flooding and combined sewer overflows (CSOs). These impacts will become more pronounced with the projected increases in frequency and intensity of extreme precipitation events due to climate change. To model the impacts of extreme precipitation events, wastewater utilities often develop Intensity, Duration, and Frequency (IDF) rainfall curves and "design storms" for use in the U.S. Environmental Protection Agency's (EPA) Storm Water Management Model (SWMM). Wastewater utilities use SWMM for planning, analysis, and facility design related to stormwater runoff, combined and sanitary sewers, and other drainage systems in urban and non-urban areas. SWMM tracks (1) the quantity and quality of runoff made within each sub-catchment; and (2) the flow rate, flow depth, and quality of water in each pipe and channel during a simulation period made up of multiple time steps. In its current format, EPA SWMM does not consider climate change projection data. Climate change may affect the relationship between intensity, duration, and frequency described by past rainfall events. Therefore, EPA is integrating climate projection data available in the Climate Resilience Evaluation and Awareness Tool (CREAT) into SWMM. CREAT is a climate risk assessment tool for utilities that provides downscaled climate change projection data for changes in the amount of rainfall in a 24-hour period for various extreme precipitation events (e.g., from 5-year to 100-year storm events). Incorporating climate change projections into SWMM will provide wastewater utilities with more comprehensive data they can use in planning for future storm events, thereby reducing the impacts to the utility and customers served from flooding and stormwater issues.

  11. Empirical comparison of color normalization methods for epithelial-stromal classification in H and E images

    OpenAIRE

    Sethi, Amit; Sha, Lingdao; Vahadane, Abhishek Ramnath; Deaton, Ryan J.; Kumar, Neeraj; Macias, Virgilia; Gann, Peter H.

    2016-01-01

    Context: Color normalization techniques for histology have not been empirically tested for their utility for computational pathology pipelines. Aims: We compared two contemporary techniques for achieving a common intermediate goal - epithelial-stromal classification. Settings and Design: Expert-annotated regions of epithelium and stroma were treated as ground truth for comparing classifiers on original and color-normalized images. Materials and Methods: Epithelial and stromal regions were ann...

  12. Moderators, mediators, and bidirectional relationships in the International Classification of Functioning, Disability and Health (ICF) framework: An empirical investigation using a longitudinal design and Structural Equation Modeling (SEM).

    Science.gov (United States)

    Rouquette, Alexandra; Badley, Elizabeth M; Falissard, Bruno; Dub, Timothée; Leplege, Alain; Coste, Joël

    2015-06-01

    The International Classification of Functioning, Disability and Health (ICF) published in 2001 describes the consequences of health conditions with three components of impairments in body structures or functions, activity limitations and participation restrictions. Two of the new features of the conceptual model were the possibility of feedback effects between each ICF component and the introduction of contextual factors conceptualized as moderators of the relationship between the components. The aim of this longitudinal study is to provide empirical evidence of these two kinds of effect. Structural equation modeling was used to analyze data from a French population-based cohort of 548 patients with knee osteoarthritis recruited between April 2007 and March 2009 and followed for three years. Indicators of the body structure and function, activity and participation components of the ICF were derived from self-administered standardized instruments. The measurement model revealed four separate factors for body structures impairments, body functions impairments, activity limitations and participation restrictions. The classic sequence from body impairments to participation restrictions through activity limitations was found at each assessment time. Longitudinal study of the ICF component relationships showed a feedback pathway indicating that the level of participation restrictions at baseline was predictive of activity limitations three years later. Finally, the moderating role of personal (age, sex, mental health, etc.) and environmental factors (family relationships, mobility device use, etc.) was investigated. Three contextual factors (sex, family relationships and walking stick use) were found to be moderators for the relationship between the body impairments and the activity limitations components. Mental health was found to be a mediating factor of the effect of activity limitations on participation restrictions. Copyright © 2015 Elsevier Ltd. All rights

  13. Design and Implementation of a CO2 Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells In a Shallow Shelf Carbonate Approaching Waterflood Depletion, Class II

    Energy Technology Data Exchange (ETDEWEB)

    Wier, Don R. Chimanhusky, John S.; Czirr, Kirk L.; Hallenbeck, Larry; Gerard, Matthew G.; Dollens, Kim B.; Owen, Rex; Gaddis, Maurice; Moshell, M.K.

    2002-11-18

    The purpose of this project was to economically design an optimum carbon dioxide (CO2) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO2 horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields.

  14. Empirical isotropic chemical shift surfaces

    International Nuclear Information System (INIS)

    Czinki, Eszter; Csaszar, Attila G.

    2007-01-01

    A list of proteins is given for which spatial structures, with a resolution better than 2.5 A, are known from entries in the Protein Data Bank (PDB) and isotropic chemical shift (ICS) values are known from the RefDB database related to the Biological Magnetic Resonance Bank (BMRB) database. The structures chosen provide, with unknown uncertainties, dihedral angles φ and ψ characterizing the backbone structure of the residues. The joint use of experimental ICSs of the same residues within the proteins, again with mostly unknown uncertainties, and ab initio ICS(φ,ψ) surfaces obtained for the model peptides For-(l-Ala) n -NH 2 , with n = 1, 3, and 5, resulted in so-called empirical ICS(φ,ψ) surfaces for all major nuclei of the 20 naturally occurring α-amino acids. Out of the many empirical surfaces determined, it is the 13C α ICS(φ,ψ) surface which seems to be most promising for identifying major secondary structure types, α-helix, β-strand, left-handed helix (α D ), and polyproline-II. Detailed tests suggest that Ala is a good model for many naturally occurring α-amino acids. Two-dimensional empirical 13C α - 1 H α ICS(φ,ψ) correlation plots, obtained so far only from computations on small peptide models, suggest the utility of the experimental information contained therein and thus they should provide useful constraints for structure determinations of proteins

  15. Empirical ground motion prediction

    Directory of Open Access Journals (Sweden)

    R. J. Archuleta

    1994-06-01

    Full Text Available New methods of site-specific ground motion prediction in the time and frequency domains are presented. A large earthquake is simulated as a composite (linear combination of observed small earthquakes (subevents assuming Aki-Brune functional models of the source time functions (spectra. Source models incorporate basic scaling relations between source and spectral parameters. Ground motion predictions are consistent with the entire observed seismic spectrum from the lowest to the highest frequencies. These methods are designed to use all the available empirical Green’s functions (or any subset of observations at a site. Thus a prediction is not biased by a single record, and different possible source-receiver paths are taken into account. Directivity is accounted for by adjusting the apparent source duration at each site. Our time-series prediction algorithm is based on determination of a non-uniform distribution of rupture times of subevents. By introducing a specific rupture velocity we avoid the major problem of deficiency of predictions around the main event's corner frequency. A novel notion of partial coherence allows us to sum subevents' amplitude spectra directly without using any information on their rupture times and phase histories. Predictions by this spectral method are not Jependent on details of rupture nucleation and propagation, location of asperities and other predominantly phase-affecting factors, responsible for uncertainties in time-domain simulations.

  16. Rational design of SnO2@C nanocomposites for lithium ion batteries by utilizing adsorption properties of MOFs.

    Science.gov (United States)

    Wang, Meihui; Yang, Hao; Zhou, Xianlong; Shi, Wei; Zhou, Zhen; Cheng, Peng

    2016-01-14

    A facile synthetic strategy is developed to prepare mono-dispersed SnO2 particles within three-dimensional porous carbon frameworks by utilizing the adsorption properties of metal-organic frameworks. This composite exhibits a high reversible capacity of 900 mA h g(-1) at 100 mA g(-1) after 50 cycles, with a stable capacity retention of 880 mA h g(-1) at 100 mA g(-1) even after 200 cycles.

  17. Constructible Authentic Representations: Designing Video Games That Enable Players to Utilize Knowledge Developed In-Game to Reason about Science

    Science.gov (United States)

    Holbert, Nathan R.; Wilensky, Uri

    2014-01-01

    While video games have become a source of excitement for educational designers, creating informal game experiences that players can draw on when thinking and reasoning in non-game contexts has proved challenging. In this paper we present a design principle for creating educational video games that enables players to draw on knowledge resources…

  18. Argumentation and Reasoning in Design: An Empirical Analysis of the Effects of Verbal Reasoning on Idea Value in Group Idea Generation

    DEFF Research Database (Denmark)

    Cramer-Petersen, Claus L.; Ahmed-Kristensen, Saeema

    2016-01-01

    doing idea generation shows that framing by certainty and deductive reasoning lead to useful incremental ideas while framing by uncertainty and abductive reasoning lead to radical ideas. The paper concludes that the way of framing ideas is indicative of how ideas add value to on-going design processes....

  19. Systematic methods and tools for design of sustainable chemical processes for CO2 utilization

    DEFF Research Database (Denmark)

    Kongpanna, Pichayapan; Babi, Deenesh K.; Pavarajarn, Varong

    2016-01-01

    and databases is based on a combined process synthesis-design-intensification method. The method consists of three stages. The synthesis-stage involves superstructure based optimization to identify promising networks that convert a given set of raw materials to a desired set of products. The design......-stage involves selection and analysis of the identified networks as a base case design in terms of operational feasibility, economics, life cycle assessment factors and sustainability measures, which are employed to establish targets for improvement in the next-stage. The innovation-stage involves generation...

  20. Conceptual designs of near surface disposal facility for radioactive waste arising from the facilities using radioisotopes and research facilities for nuclear energy development and utilization

    International Nuclear Information System (INIS)

    Sakai, Akihiro; Yoshimori, Michiro; Okoshi, Minoru; Yamamoto, Tadatoshi; Abe, Masayoshi

    2001-03-01

    Various kinds of radioactive waste is generating from the utilization of radioisotopes in the field of science, technology, etc. and the utilization and development of nuclear energy. In order to promote the utilization of radionuclides and the research activities, it is necessary to treat and dispose of radioactive waste safely and economically. Japan Nuclear Cycle Development Institute (JNC), Japan Radioisotope Association (JRIA) and Japan Atomic Energy Research Institute (JAERI), which are the major waste generators in Japan in these fields, are promoting the technical investigations for treatment and disposal of the radioactive waste co-operately. Conceptual design of disposal facility is necessary to demonstrate the feasibility of waste disposal business and to determine the some conditions such as the area size of the disposal facility. Three institutes share the works to design disposal facility. Based on our research activities and experiences of waste disposal, JAERI implemented the designing of near surface disposal facilities, namely, simple earthen trench and concrete vaults. The designing was performed based on the following three assumed site conditions to cover the future site conditions: (1) Case 1 - Inland area with low groundwater level, (2) Case 2 - Inland area with high groundwater level, (3) Case 3 - Coastal area. The estimation of construction costs and the safety analysis were also performed based on the designing of facilities. The safety assessment results show that the safety for concrete vault type repository is ensured by adding low permeability soil layer, i.e. mixture of soil and bentonite, surrounding the vaults not depending on the site conditions. The safety assessment results for simple earthen trench also show that their safety is ensured not depending on the site conditions, if they are constructed above groundwater levels. The construction costs largely depend on the depth for excavation to build the repositories. (author)

  1. Empirically Based Myths: Astrology, Biorhythms, and ATIs.

    Science.gov (United States)

    Ragsdale, Ronald G.

    1980-01-01

    A myth may have an empirical basis through chance occurrence; perhaps Aptitude Treatment Interactions (ATIs) are in this category. While ATIs have great utility in describing, planning, and implementing instruction, few disordinal interactions have been found. Article suggests narrowing of ATI research with replications and estimates of effect…

  2. Design of an empirical process model and algorithm for the Tungsten Inert Gas wire+arc additive manufacture of TI-6AL-4V components

    OpenAIRE

    Martina, Filomeno; Williams, Stewart; Colegrove, Paul

    2013-01-01

    In the wire+arc additive manufacture process parameters can be varied to achieve a wide range of deposit widths, as well as layer heights. Pulsed Tungsten Inert Gas was chosen as the deposition process. A working envelope was developed, which ensures unfeasible parameters combinations are excluded from the algorithm. Thanks to an extensive use of a statistically designed experiment, it was possible to produce process equations through linear regression, for both wall width and ...

  3. Development of a Measurement Instrument for Website Design Utilizing Analytic Hierarchy Process (AHP) Multi-Attribute Decision Modeling

    OpenAIRE

    Ron Cheek; Martha L. Sale; Colleen Schwarz

    2015-01-01

    For many organizations their websites are the first impression customers have of their companies. The impact and importance of web design on organizations continues to dramatically increase. Yet many organizations continue to struggle to find tools to strategically analyze their websites and overall online presence. While there have been numerous studies offering “best practices†for website design, most of these are dated and do not take into consideration new applications and social medi...

  4. Empirical Philosophy of Science

    DEFF Research Database (Denmark)

    Mansnerus, Erika; Wagenknecht, Susann

    2015-01-01

    The book examines the emerging approach of using qualitative methods, such as interviews and field observations, in the philosophy of science. Qualitative methods are gaining popularity among philosophers of science as more and more scholars are resorting to empirical work in their study...... of scientific practices. At the same time, the results produced through empirical work are quite different from those gained through the kind of introspective conceptual analysis more typical of philosophy. This volume explores the benefits and challenges of an empirical philosophy of science and addresses...

  5. Theological reflections on empire

    Directory of Open Access Journals (Sweden)

    Allan A. Boesak

    2009-11-01

    Full Text Available Since the meeting of the World Alliance of Reformed Churches in Accra, Ghana (2004, and the adoption of the Accra Declaration, a debate has been raging in the churches about globalisation, socio-economic justice, ecological responsibility, political and cultural domination and globalised war. Central to this debate is the concept of empire and the way the United States is increasingly becoming its embodiment. Is the United States a global empire? This article argues that the United States has indeed become the expression of a modern empire and that this reality has considerable consequences, not just for global economics and politics but for theological refl ection as well.

  6. Empires, Nations, and Revolutions.

    Science.gov (United States)

    Adelman, Jeremy

    2018-01-01

    This essay examines the ways in which the age of revolutions expanded the repertoire of political ideas and identities available to new and old political subjects. It questions the traditional narrative that replaces a model of old regimes and empires with a new one of imagined unitary nation-states. Instead, it argues that the nature of the political crisis of the Iberian empires gave rise to a reinvention of familiar categories, like monarchy and empire, and sired a wider range of new ones that did not fit the national mold.

  7. Design, performance and cost of energy from high concentration and flat-plate utility-scale PV systems

    International Nuclear Information System (INIS)

    Stolte, W.J.; Whisnant, R.A.; McGowin, C.R.

    1993-01-01

    This paper presents the results of a recent study to assess the near-term cost of power in central station applications. Three PV technologies were evaluated: Fresnel-lens high-concentration photovoltaic (HCPV), central receiver HCPV, and flat-plate PV using thin-film copper indium diselenide (CIS) cell technology. Baseline assumptions included PV cell designs and performances projected for the 1995 timeframe, 25 and 100 MW/year cell manufacturing rates, 50 MW power plant size, and mature technology cost and performance estimates. The plant design characteristics are highlighted. Potential sites were evaluated and selected for the PV power plants (Carrisa Plains, CA and Apalachicola, FL) and cell manufacturing plants (Dallas-Fort Worth, TX). Conceptual designs and cost estimates were developed for the plants and their components. Plant performance was modeled and the designs were optimized to minimize levelized energy costs. Overall, the flat plate design exhibited the lowest energy costs among the designs evaluated. Its levelized energy costs at the Carrisa Plains site were estimated to be 11.8 and 10.8 cents/kWh (1990 $) for 25 and 100 MW/year module production rates, respectively. This meets the 12 cents/kWh DOE near-term goal. The energy cost of the Fresnel lens plant (at Carrisa Plains and a 100 MW/year cell production rate) was estimated to be 12.4 cents/kWh and the corresponding central receiver energy cost was estimated to be 13.1 cents/kWh, both of which are very close to the DOE goal. Further design optimization efforts are still warranted and can be expected to reduce plant capital costs

  8. Design Study of Modular Nuclear Power Plant with Small Long Life Gas Cooled Fast Reactors Utilizing MOX Fuel

    Science.gov (United States)

    Ilham, Muhammad; Su'ud, Zaki

    2017-01-01

    Growing energy needed due to increasing of the world’s population encourages development of technology and science of nuclear power plant in its safety and security. In this research, it will be explained about design study of modular fast reactor with helium gas cooling (GCFR) small long life reactor, which can be operated over 20 years. It had been conducted about neutronic design GCFR with Mixed Oxide (UO2-PuO2) fuel in range of 100-200 MWth NPPs of power and 50-60% of fuel fraction variation with cylindrical pin cell and cylindrical balance of reactor core geometry. Calculation method used SRAC-CITATION code. The obtained results are the effective multiplication factor and density value of core reactor power (with geometry optimalization) to obtain optimum design core reactor power, whereas the obtained of optimum core reactor power is 200 MWth with 55% of fuel fraction and 9-13% of percentages.

  9. Life Writing After Empire

    DEFF Research Database (Denmark)

    in order to understand how individual life writing reflects broader societal changes. From far-flung corners of the former British Empire, people have turned to life writing to manage painful or nostalgic memories, as well as to think about the past and future of the nation anew through the personal......A watershed moment of the twentieth century, the end of empire saw upheavals to global power structures and national identities. However, decolonisation profoundly affected individual subjectivities too. Life Writing After Empire examines how people around the globe have made sense of the post...... experience. In a range of innovative and insightful contributions, some of the foremost scholars of the field challenge the way we think about narrative, memory and identity after empire. This book was originally published as a special issue of Life Writing....

  10. Design and development of an automotive propulsion system utilizing a Rankine cycle engine (water based fluid). Final report

    Energy Technology Data Exchange (ETDEWEB)

    Demler, R.L.

    1977-09-01

    Under EPA and ERDA sponsorship, SES successfully designed, fabricated and tested the first federally sponsored steam powered automobile. The automobile - referred to as the simulator - is a 1975 Dodge Monaco standard size passenger car with the SES preprototype Rankine cycle automotive propulsion system mounted in the engine compartment. In the latter half of 1975, the simulator successfully underwent test operations at the facilities of SES in Watertown, Massachusetts and demonstrated emission levels below those of the stringent federally established automotive requirements originally set for implementation by 1976. The demonstration was accomplished during testing over the Federal Driving Cycle on a Clayton chassis dynamometer. The design and performance of the vehicle are described.

  11. Process Design Report for Stover Feedstock: Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis for Corn Stover

    Energy Technology Data Exchange (ETDEWEB)

    Aden, A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ruth, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ibsen, K. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jechura, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Neeves, K. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sheehan, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wallace, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Montague, L. [Harris Group, Seattle, WA (United States); Slayton, A. [Harris Group, Seattle, WA (United States); Lukas, J. [Harris Group, Seattle, WA (United States)

    2002-06-01

    The U.S. Department of Energy (DOE) is promoting the development of ethanol from lignocellulosic feedstocks as an alternative to conventional petroleum-based transportation fuels. DOE funds both fundamental and applied research in this area and needs a method for predicting cost benefits of many research proposals. To that end, the National Renewable Energy Laboratory (NREL) has modeled many potential process designs and estimated the economics of each process during the last 20 years. This report is an update of the ongoing process design and economic analyses at NREL.

  12. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis for Corn Stover

    Energy Technology Data Exchange (ETDEWEB)

    Aden, A.; Ruth, M.; Ibsen, K.; Jechura, J.; Neeves, K.; Sheehan, J.; Wallace, B.; Montague, L.; Slayton, A.; Lukas, J.

    2002-06-01

    This report is an update of NREL's ongoing process design and economic analyses of processes related to developing ethanol from lignocellulosic feedstocks. The U.S. Department of Energy (DOE) is promoting the development of ethanol from lignocellulosic feedstocks as an alternative to conventional petroleum-based transportation fuels. DOE funds both fundamental and applied research in this area and needs a method for predicting cost benefits of many research proposals. To that end, the National Renewable Energy Laboratory (NREL) has modeled many potential process designs and estimated the economics of each process during the last 20 years. This report is an update of the ongoing process design and economic analyses at NREL. We envision updating this process design report at regular intervals; the purpose being to ensure that the process design incorporates all new data from NREL research, DOE funded research and other sources, and that the equipment costs are reasonable and consistent with good engineering practice for plants of this type. For the non-research areas this means using equipment and process approaches as they are currently used in industrial applications. For the last report, published in 1999, NREL performed a complete review and update of the process design and economic model for the biomass-to-ethanol process utilizing co-current dilute acid prehydrolysis with simultaneous saccharification (enzymatic) and co-fermentation. The process design included the core technologies being researched by the DOE: prehydrolysis, simultaneous saccharification and co-fermentation, and cellulase enzyme production. In addition, all ancillary areas--feed handling, product recovery and purification, wastewater treatment (WWT), lignin combustor and boiler-turbogenerator, and utilities--were included. NREL engaged Delta-T Corporation (Delta-T) to assist in the process design evaluation, the process equipment costing, and overall plant integration. The process design

  13. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios; TOPICAL

    International Nuclear Information System (INIS)

    Wooley, R.; Ruth, M.; Sheehan, J.; Ibsen, K.; Majdeski, H.; Galvez, A.

    1999-01-01

    The National Renewable Energy Laboratory (NREL) has undertaken a complete review and update of the process design and economic model for the biomass-to-ethanol enzymatic based process. The process design includes the core technologies being researched by the U.S. Department of Energy (DOE): prehydrolysis, simultaneous saccharification and co-fermentation, and cellulase enzyme production. In addition, all ancillary areas-feed handling, product recovery and purification, wastewater treatment lignin burner and boiler-turbogenerator, and utilities-are included. NREL engaged Delta-T Corporation to assist in the process design evaluation, equipment costing, and overall plant integration. The process design and costing for the lignin burner and boiler turbogenerator has been reviewed by Reaction Engineering Inc. and the wastewater treatment by Merrick and Company. An overview of both reviews is included here. The purpose of this update was to ensure that the process design and equipment costs were reasonable and consistent with good engineering practice for plants of this type using available technical data. This work has resulted in an economic model that can be used to predict the cost of producing ethanol from cellulosic biomass using this technology if a plant were to be built in the next few years. The model was also extended using technology improvements that are expected to be developed based on the current DOE research plan. Future process designs and cost estimates are given for the years 2005, 2010, and 2015

  14. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Wooley, R.; Ruth, M.; Sheehan, J.; Ibsen, K.; Majdeski, H.; Galvez, A.

    1999-07-20

    The National Renewable Energy Laboratory (NREL) has undertaken a complete review and update of the process design and economic model for the biomass-to-ethanol enzymatic based process. The process design includes the core technologies being researched by the U.S. Department of Energy (DOE): prehydrolysis, simultaneous saccharification and co-fermentation, and cellulase enzyme production. In addition, all ancillary areas--feed handling, product recovery and purification, wastewater treatment lignin burner and boiler--turbogenerator, and utilities--are included. NREL engaged Delta-T Corporation to assist in the process design evaluation, equipment costing, and overall plant integration. The process design and costing for the lignin burner and boiler turbogenerator has been reviewed by Reaction Engineering Inc. and the wastewater treatment by Merrick and Company. An overview of both reviews is included here. The purpose of this update was to ensure that the process design and equipment costs were reasonable and consistent with good engineering practice for plants of this type using available technical data. This work has resulted in an economic model that can be used to predict the cost of producing ethanol from cellulosic biomass using this technology if a plant were to be built in the next few years. The model was also extended using technology improvements that are expected to be developed based on the current DOE research plan. Future process designs and cost estimates are given for the years 2005, 2010, and 2015.

  15. Energy Conservation Alternatives Study (ECAS): Conceptual Design and Implementation Assessment of a Utility Steam Plant with Conventional Furnace and Wet Lime Stack Gas Scrubbers

    Science.gov (United States)

    Brown, Dale H.

    1976-01-01

    A study was performed to estimate the technical/economic characteristics of a steam power plant (3500 pounds per square inch gauge, 1000 degrees Fahrenheit / 1000 degrees Fahrenheit) with a coal-burning radiant furnace and a wet lime stack gas scrubber to control sulfur emissions. Particulate emissions were controlled by an electrostatic precipitator operating at 300 degrees Fahrenheit. The stack gas from the scrubber was reheated from 125 degrees Fahrenheit to 250 degrees Fahrenheit as a base case, and from 125 degrees Fahrenheit to 175 degrees Fahrenheit as an alternate case. The study was performed on a basis consistent with the General Electric ECAS Phase II evaluation of advanced energy conversion systems for electric utility baseload applications using coal or coal-derived fuels. A conceptual design of the power plant was developed, including the on-site calcination of limestone to lime and the provision of sludge ponds to store the products of flue gas scrubbing. From this design, estimates were derived for power plant efficiency, capital cost, environmental intrusion characteristics, natural resource requirements, and cost of electricity at an assumed capacity factor of 65 percent. An implementation assessment was performed where factors affecting applicability of the conceptual design power plant in electric utility generation systems were appraised. At 250 degrees Fahrenheit and 175 degrees Fahrenheit stack gas temperatures respectively, the plants showed a cost of electricity of 39.8 and 37.0 mills per kilowatt-hours and overall plant efficiencies of 32 percent and 34 percent.

  16. Utilizing food effects to overcome challenges in delivery of lipophilic bioactives: structural design of medical and functional foods.

    Science.gov (United States)

    McClements, David Julian

    2013-12-01

    The oral bioavailability of many lipophilic bioactives, such as pharmaceuticals and nutraceuticals, is relatively low due to their poor solubility, permeability and/or chemical stability within the human gastrointestinal tract (GIT). The oral bioavailability of lipophilic bioactives can be improved by designing food matrices that control their release, solubilization, transport and absorption within the GIT. This article discusses the challenges associated with delivering lipophilic bioactive components, the impact of food composition and structure on oral bioavailability and the design of functional and medical foods for improving the oral bioavailability of lipophilic bioactives. Food-based delivery systems can be used to improve the oral bioavailability of lipophilic bioactives. There are a number of potential advantages to delivering lipophilic bioactives using functional or medical foods: greater compliance than conventional delivery forms; increased bioavailability and efficacy; and reduced variability in biological effects. However, food matrices are structurally complex multicomponent materials and research is still needed to identify optimum structures and compositions for particular bioactives.

  17. Development of Design Standards and Guidelines for Electromagnetic Compatibility and Lightning Protection for Spacecraft Utilizing Composite Materials

    Science.gov (United States)

    Camp, Dennis W.

    1997-01-01

    This final report presents information concerning technical accomplishments by Tec-Masters, Inc. (TMI) for this contract effort. This effort included the accomplishment and/or submission by TMI of the following items: (1) Literature Survey Report, Electrical Properties of Non-Metallic Composites by Mr. Hugh W. Denny; (2) Interim Report, Composite Materials - Conductivity, Shielding Effectiveness, and Current Carrying Capability by Mr. Ross W. Evans; (3) Fault Current Test Plan by Mr. Ross W. Evans (4) Fault Current Test Procedure by Mr. Ross W. Evans (5) Test Report, Fault Current Through Graphite Filament Reinforced Plastic, NASA CR-4774, Marshall Space Flight Center, Alabama, September 1996, by Mr. Ross W. Evans; (6) Test Plan, Lightning Effects on Composite Materials by Mr. Ross W. Evans; (7) Test Report, Lightning Effects on Composite Materials, NASA CR-4783, Marshall Space Flight Center, Alabama, February 1997, by Mr. Ross W. Evans; (8) Design Guidelines for Shielding Effectiveness, Current Carrying Capability, and the Enhancement of Conductivity of Composite Materials, NASA CR-4784, Marshall Space Flight Center, Alabama, September 1996, by Mr. Ross W. Evans. These items are not attached but are considered to be a part of this final report. Efforts on two additional items were accomplished at no increase in cost to NASA/MSFC. These items consisted of updating the 'MSFC EMC Design and Interference Control Handbook,' and revising the 'Design Guidelines for Shielding Effectiveness, Current Carrying Capability, and the Enhancement of Conductivity of Composite Materials.'

  18. Layout designs of surface barrier coatings for boosting the capability of oxygen/vapor obstruction utilized in flexible electronics

    Science.gov (United States)

    Lee, Chang-Chun; Huang, Pei-Chen; He, Jing-Yan

    2018-04-01

    Organic light-emitting diode-based flexible and rollable displays have become a promising candidate for next-generation flexible electronics. For this reason, the design of surface multi-layered barriers should be optimized to enhance the long-term mechanical reliability of a flexible encapsulation that prevents the penetration of oxygen and vapor. In this study, finite element-based stress simulation was proposed to estimate the mechanical reliability of gas/vapor barrier design with low-k/silicon nitride (low-k/SiNx) stacking architecture. Consequently, stress-induced failure of critical thin films within the flexible display under various bending conditions must be considered. The feasibility of one pair SiO2/SiNx barrier design, which overcomes the complex lamination process, and the critical bending radius, which is decreased to 1.22 mm, were also examined. In addition, the influence of distance between neutral axes to the concerned layer surface dominated the induced-stress magnitude rather than the stress compliant mechanism provided from stacked low-k films.

  19. A First Approach to Design Mobility Function and Noise Filter in VLC System Utilizing Low-cost Analog Circuits

    Directory of Open Access Journals (Sweden)

    Syifaul Fuada

    2017-07-01

    Full Text Available Visible Light Communication (VLC as one of wireless technology must be able to offer a good capability as mobile communication system. The signal will be faded when the distance and angle of LED to photo-detector become higher at a certain distance. Other problem at VLC system is light interference noise which is caused by flicker effect from other light sources such as incandescent, fluorescent, DC-lamp (i.e. flashlight and the sunlight. Each of lights have specific carried signal characteristics and it can influences the VLC system. In this paper we offer design of mobile VLC system based on analog domain. We use Automatic Gain Controller (AGC circuit using commercially available IC and it will be placed at analog front-end receiver side. AGC can self-adjust its gain according to the input signal amplitude.  We also design analog filter to eliminate all interferences noise spectrum which is existed under 50 KHz. We design both circuits, analog filter and AGC in VLC receiver system with low-cost. The test data are obtained through the simulation and achieved good results in ideal condition.

  20. Numerical Study of the Generic Sports Utility Vehicle Design with a Drag Reduction Add-On Device

    Directory of Open Access Journals (Sweden)

    Shubham Singh

    2014-01-01

    Full Text Available CFD simulations using ANSYS FLUENT 6.3.26 have been performed on a generic SUV design and the settings are validated using the experimental results investigated by Khalighi. Moreover, an add-on inspired by the concept presented by Englar at GTRI for drag reduction has been designed and added to the generic SUV design. CFD results of add-on model and the basic SUV model have been compared for a number of aerodynamic parameters. Also drag coefficient, drag force, mean surface pressure, mean velocities, and Cp values at different locations in the wake have been compared for both models. The main objective of the study is to present a new add-on device which may be used on SUVs for increasing the fuel efficiency of the vehicle. Mean pressure results show an increase in the total base pressure on the SUV after using the device. An overall reduction of 8% in the aerodynamic drag coefficient on the add-on SUV has been investigated analytically in this study.

  1. Advanced system demonstration for utilization of biomass as an energy source. Volume I. Scope and design criteria and project summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    The information in this document is the result of an intensive engineering effort to demonstrate the feasibility of biomass-fueled boilers in cogeneration applications. This design package is based upon a specific site in the State of Maine. However, the design is generic in nature and could serve as a model for other biomass conversion facilities located anywhere biomass is abundant. The project's purpose and summary information are presented: the plant, its concept of operation; and other overall information are described. The capital cost estimate for the plant, and the basis upon which it was obtained are given; a schedule of key milestones and activities required to construct the plant and put it into operation is presented; and the general findings in areas that affect the viability of the project are discussed. The technical design, biomass study, environmental impact, commercialization, and economic factors are addressed. Each major plant area and the equipment and facilities that each includes are discussed in depth. Some overall plant requirements, including noise control, reliability, maintainability, and safety, are detailed. The results of each study relating to alternatives considered for optimizing plant operation parameters and specific system process schemes are briefly presented. All economic factors that affect the feasibility and viability of the biomass project are defined and evaluated.

  2. Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.

    Science.gov (United States)

    Lin, Shuqun; Wrobleski, Stephen T; Hynes, John; Pitt, Sidney; Zhang, Rosemary; Fan, Yi; Doweyko, Arthur M; Kish, Kevin F; Sack, John S; Malley, Mary F; Kiefer, Susan E; Newitt, John A; McKinnon, Murray; Trzaskos, James; Barrish, Joel C; Dodd, John H; Schieven, Gary L; Leftheris, Katerina

    2010-10-01

    The design, synthesis, and structure-activity relationships (SAR) of a series of 2-aminothiazol-5-yl-pyrimidines as novel p38α MAP kinase inhibitors are described. These efforts led to the identification of 41 as a potent p38α inhibitor that utilizes a unique nitrogen-sulfur intramolecular nonbonding interaction to stabilize the conformation required for binding to the p38α active site. X-ray crystallographic studies that confirm the proposed binding mode of this class of inhibitors in p38 α and provide evidence for the proposed intramolecular nitrogen-sulfur interaction are discussed. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. The utilization of websites for fundraising by NCI-designated cancer centers: Examining the capacity for dialogic communication with prospective donors.

    Science.gov (United States)

    Erwin, Cathleen O; Dias, Ashley M

    2016-01-01

    The study employs a dialogic public relations framework to explore the utilization of the Internet for fundraising by nonprofit health care organizations-specifically, NCI-designated cancer centers. Cancer centers have been noted for effective websites and for being highly engaged in fundraising, which is characterized as relationship marketing. Results indicate all but one cancer center use websites and social media for fundraising but are limited in capacity for two-way symmetrical dialogue. Results are discussed and recommendations are made for future research.

  4. A Strategy to Design High-Density Nanoscale Devices utilizing Vapor Deposition of Metal Halide Perovskite Materials.

    Science.gov (United States)

    Hwang, Bohee; Lee, Jang-Sik

    2017-08-01

    The demand for high memory density has increased due to increasing needs of information storage, such as big data processing and the Internet of Things. Organic-inorganic perovskite materials that show nonvolatile resistive switching memory properties have potential applications as the resistive switching layer for next-generation memory devices, but, for practical applications, these materials should be utilized in high-density data-storage devices. Here, nanoscale memory devices are fabricated by sequential vapor deposition of organolead halide perovskite (OHP) CH 3 NH 3 PbI 3 layers on wafers perforated with 250 nm via-holes. These devices have bipolar resistive switching properties, and show low-voltage operation, fast switching speed (200 ns), good endurance, and data-retention time >10 5 s. Moreover, the use of sequential vapor deposition is extended to deposit CH 3 NH 3 PbI 3 as the memory element in a cross-point array structure. This method to fabricate high-density memory devices could be used for memory cells that occupy large areas, and to overcome the scaling limit of existing methods; it also presents a way to use OHPs to increase memory storage capacity. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Design and utilization of a Flight Test Engineering Database Management System at the NASA Dryden Flight Research Facility

    Science.gov (United States)

    Knighton, Donna L.

    1992-01-01

    A Flight Test Engineering Database Management System (FTE DBMS) was designed and implemented at the NASA Dryden Flight Research Facility. The X-29 Forward Swept Wing Advanced Technology Demonstrator flight research program was chosen for the initial system development and implementation. The FTE DBMS greatly assisted in planning and 'mass production' card preparation for an accelerated X-29 research program. Improved Test Plan tracking and maneuver management for a high flight-rate program were proven, and flight rates of up to three flights per day, two times per week were maintained.

  6. Reducing the impact of unplanned urbanization on a riparian ecosystem: a case study on designing a plan for sustainable utilization of flood plains on river Ravi

    International Nuclear Information System (INIS)

    Khan, A.U.

    2005-01-01

    This work emphasizes that utilization of flood plain must be preceded by a study that shows the extent of the flood plain with the primary objective to management and maintaining the integrity of riparian areas for their multiple values. One such design is presented here where the riparian land is used for designing a municipal waste water treatment plant in order to provide a reward feedback to river Ravi. Since the space is becoming expensive for setting up of a treatment plant, this high risk piece of land instead of being used for land filling and housing schemes should be used for designing multipurpose environmentally sustainable projects. The treatment plant is designed to mimic the functional properties of riparian corridor flood plains. This design is based on integrated series of interconnected basins including a sedimentation basin, infiltration basin and a created wetland. This system would promote ground water recharge and passively remove pollutants through a combination of filtering, settling and biological treatment mechanisms and providing an attractive recreation and learning environment for the community at large. Additionally, benefits of such treatment will allow a direct recycling of water and nutrients for beneficial use; the sewage becomes a valuable natural resource that is not simply disposed of untreated. (author)

  7. Performance Data from a Wind-Tunnel Test of Two Main-rotor Blade Designs for a Utility-Class Helicopter

    Science.gov (United States)

    Singleton, Jeffrey D.; Yeager, William T., Jr.; Wilbur, Matthew L.

    1990-01-01

    An investigation was conducted in the NASA Langley Transonic Dynamics Tunnel to evaluate an advanced main rotor designed for use on a utility class helicopter, specifically the U.S. Army UH-60A Blackhawk. This rotor design incorporated advanced twist, airfoil cross sections, and geometric planform. For evaluation purposes, the current UH-60A main rotor was also tested and is referred to as the baseline blade set. A total of four blade sets were tested. One set of both the baseline and the advanced rotors were dynamically scaled to represent a full scale helicopter rotor blade design. The remaining advanced and baseline blade sets were not dynamically scaled so as to isolate the effects of structural elasticity. The investigation was conducted in hover and at rotor advance ratios ranging from 0.15 to 0.4 at a range of nominal test medium densities from 0.00238 to 0.009 slugs/cu ft. This range of densities, coupled with varying rotor lift and propulsive force, allowed for the simulation of several vehicle gross weight and density altitude combinations. Performance data are presented for all blade sets without analysis; however, cross referencing of data with flight condition may be useful to the analyst for validating aeroelastic theories and design methodologies as well as for evaluating advanced design parameters.

  8. Empirical process modeling in fast breeder reactors

    International Nuclear Information System (INIS)

    Ikonomopoulos, A.; Endou, A.

    1998-01-01

    A non-linear multi-input/single output (MISO) empirical model is introduced for monitoring vital system parameters in a nuclear reactor environment. The proposed methodology employs a scheme of non-parametric smoothing that models the local dynamics of each fitting point individually, as opposed to global modeling techniques--such as multi-layer perceptrons (MLPs)--that attempt to capture the dynamics of the entire design space. The stimulation for employing local models in monitoring rises from one's desire to capture localized idiosyncrasies of the dynamic system utilizing independent estimators. This approach alleviates the effect of negative interference between old and new observations enhancing the model prediction capabilities. Modeling the behavior of any given system comes down to a trade off between variance and bias. The building blocks of the proposed approach are tailored to each data set through two separate, adaptive procedures in order to optimize the bias-variance reconciliation. Hetero-associative schemes of the technique presented exhibit insensitivity to sensor noise and provide the operator with accurate predictions of the actual process signals. A comparison between the local model and MLP prediction capabilities is performed and the results appear in favor of the first method. The data used to demonstrate the potential of local regression have been obtained during two startup periods of the Monju fast breeder reactor (FBR)

  9. Design of experiments utilization to map the processing capabilities of a micro-spray dryer: particle design and throughput optimization in support of drug discovery.

    Science.gov (United States)

    Ormes, James D; Zhang, Dan; Chen, Alex M; Hou, Shirley; Krueger, Davida; Nelson, Todd; Templeton, Allen

    2013-02-01

    There has been a growing interest in amorphous solid dispersions for bioavailability enhancement in drug discovery. Spray drying, as shown in this study, is well suited to produce prototype amorphous dispersions in the Candidate Selection stage where drug supply is limited. This investigation mapped the processing window of a micro-spray dryer to achieve desired particle characteristics and optimize throughput/yield. Effects of processing variables on the properties of hypromellose acetate succinate were evaluated by a fractional factorial design of experiments. Parameters studied include solid loading, atomization, nozzle size, and spray rate. Response variables include particle size, morphology and yield. Unlike most other commercial small-scale spray dryers, the ProCepT was capable of producing particles with a relatively wide mean particle size, ca. 2-35 µm, allowing material properties to be tailored to support various applications. In addition, an optimized throughput of 35 g/hour with a yield of 75-95% was achieved, which affords to support studies from Lead-identification/Lead-optimization to early safety studies. A regression model was constructed to quantify the relationship between processing parameters and the response variables. The response surface curves provide a useful tool to design processing conditions, leading to a reduction in development time and drug usage to support drug discovery.

  10. Science and the French Empire.

    Science.gov (United States)

    Osborne, Michael A

    2005-03-01

    Scholarly interest in French colonial science, interpreted to include colonial medical and scientific institutions as well as personages and other "actors" in France serving colonial agendas, has been robust for some two decades. This essay characterizes the complex and interlinked historical relationships between French metropolitan and colonial science as one of asymmetric coevolution. In analyzing scholarship on diverse topics from physics and military technology to colonial botany, medicine, geography, and racial theory, it interrogates the concepts of French nation and French empire and questions the historiographical and explanatory utility of the core-periphery model. Special scrutiny falls on a trope common to historigraphical studies of the postrevolutionary era, that of a firm French nationalism enabling largely rational colonial agendas and the promotion of these agendas by highly centralized Parisian bureaucracies. The essay calls for a reading of French history inclusive of regional colonialist activities and argues for the prevalence of municipal and regional maritime, technological, scientific, and military interests in constructing the modern French empire.

  11. Empirical philosophy of science

    DEFF Research Database (Denmark)

    Wagenknecht, Susann; Nersessian, Nancy J.; Andersen, Hanne

    2015-01-01

    A growing number of philosophers of science make use of qualitative empirical data, a development that may reconfigure the relations between philosophy and sociology of science and that is reminiscent of efforts to integrate history and philosophy of science. Therefore, the first part...... of this introduction to the volume Empirical Philosophy of Science outlines the history of relations between philosophy and sociology of science on the one hand, and philosophy and history of science on the other. The second part of this introduction offers an overview of the papers in the volume, each of which...... is giving its own answer to questions such as: Why does the use of qualitative empirical methods benefit philosophical accounts of science? And how should these methods be used by the philosopher?...

  12. Pareto utility

    NARCIS (Netherlands)

    Ikefuji, M.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.H.M.

    2013-01-01

    In searching for an appropriate utility function in the expected utility framework, we formulate four properties that we want the utility function to satisfy. We conduct a search for such a function, and we identify Pareto utility as a function satisfying all four desired properties. Pareto utility

  13. Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India.

    Science.gov (United States)

    Pemberton, T J; Jakobsson, M; Conrad, D F; Coop, G; Wall, J D; Pritchard, J K; Patel, P I; Rosenberg, N A

    2008-07-01

    When performing association studies in populations that have not been the focus of large-scale investigations of haplotype variation, it is often helpful to rely on genomic databases in other populations for study design and analysis - such as in the selection of tag SNPs and in the imputation of missing genotypes. One way of improving the use of these databases is to rely on a mixture of database samples that is similar to the population of interest, rather than using the single most similar database sample. We demonstrate the effectiveness of the mixture approach in the application of African, European, and East Asian HapMap samples for tag SNP selection in populations from India, a genetically intermediate region underrepresented in genomic studies of haplotype variation.

  14. Utilizing Focus Groups with Potential Participants and Their Parents: An Approach to Inform Study Design in a Large Clinical Trial.

    Science.gov (United States)

    Kadimpati, Sandeep; McCormick, Jennifer B; Chiu, Yichen; Parker, Ashley B; Iftikhar, Aliya Z; Flick, Randall P; Warner, David O

    2014-01-01

    In the recent literature, there has been some evidence that exposure of children to anesthetic procedures during the first two years of life may impair cognitive function and learning in later life. We planned a clinical study to quantify this risk, a study involving testing 1,000 children for neurodevelopmental deficits. As a part of this planning, we conducted focus groups involving potential participants and their parents to elicit information regarding three issues: communications with the community and potential participants, recruitment and consent processes, and the return of neurodevelopmental testing results. Three focus groups were conducted with the parents of potential participants and one focus group was conducted with an 18-19 year old group; each group consisted of 6-10 participants. The moderated discussions had questions about recruitment, consenting issues, and expectations from the study about return of both overall trial findings and individual research test results. The focus group data gave us an insight on potential participants' views on recruitment, consenting, communications about the study, and expectations about return of both overall trial findings and individual research test results. The concerns expressed were largely addressable. In addition, the concern we had about some parents enrolling their children in the study solely for the sake of getting their child's cognitive function results was dispelled. We found that the individuals participating in our focus groups were generally enthusiastic about the large clinical study and could see the value in answering the study question. The data from the focus groups were used to inform changes to the recruitment and consent process. Focus group input was also instrumental in affirming the study design regarding return of results. Our experience suggests that the approach we used may serve as a model for other investigators to help inform the various elements of clinical study design, in

  15. Empirical philosophy of science

    DEFF Research Database (Denmark)

    Wagenknecht, Susann; Nersessian, Nancy J.; Andersen, Hanne

    2015-01-01

    A growing number of philosophers of science make use of qualitative empirical data, a development that may reconfigure the relations between philosophy and sociology of science and that is reminiscent of efforts to integrate history and philosophy of science. Therefore, the first part...... of this introduction to the volume Empirical Philosophy of Science outlines the history of relations between philosophy and sociology of science on the one hand, and philosophy and history of science on the other. The second part of this introduction offers an overview of the papers in the volume, each of which...

  16. Empirical comparison of theories

    International Nuclear Information System (INIS)

    Opp, K.D.; Wippler, R.

    1990-01-01

    The book represents the first, comprehensive attempt to take an empirical approach for comparative assessment of theories in sociology. The aims, problems, and advantages of the empirical approach are discussed in detail, and the three theories selected for the purpose of this work are explained. Their comparative assessment is performed within the framework of several research projects, which among other subjects also investigate the social aspects of the protest against nuclear power plants. The theories analysed in this context are the theory of mental incongruities and that of the benefit, and their efficiency in explaining protest behaviour is compared. (orig./HSCH) [de

  17. Why Culture Matters: An Empirically-Based Pre-Deployment Training Program

    National Research Council Canada - National Science Library

    Chandler, Jennifer V

    2005-01-01

    .... This thesis utilizes a systems approach for analyzing both the operational environment and culture, recommending an empirically-based pre-deployment training program that trains military members...

  18. Minimum Thresholds of Monte Carlo Cycles for Nigerian Empirical ...

    African Journals Online (AJOL)

    Monte Carlo simulation has proven to be an eective means of incorporating reliability analysisinto the Mechanistic-Empirical (M-E) design process for exible pavements. Nigerian Empirical-Mechanistic Pavement Analysis and Design System procedure for Nigeria Environments has beenproposed. This work aimed at ...

  19. Utilization of an amphipathic leucine zipper sequence to design antibacterial peptides with simultaneous modulation of toxic activity against human red blood cells.

    Science.gov (United States)

    Ahmad, Aqeel; Yadav, Sharada Prasad; Asthana, Neeta; Mitra, Kalyan; Srivastava, Swati Prakash; Ghosh, Jimut Kanti

    2006-08-04

    The toxicity of naturally occurring or designed antimicrobial peptides is a major barrier for converting them into drugs. To synthesize antimicrobial peptides with reduced toxicity, several amphipathic peptides were designed based on the leucine zipper sequence. The first one was a leucine zipper peptide (LZP); in others, leucine residues at the a- and/or d-position were substituted with single or double alanine residues. The results showed that LZP and its analogs exhibited appreciable and similar antibacterial activity against the tested gram-positive and gram-negative bacteria. However, the substitution of alanine progressively lowered the toxicity of LZP against human red blood cells (hRBCs). The substitution of leucine with alanine impaired the binding and localization of LZP to hRBCs, but had little effect on the peptide-induced damage of Escherichia coli cells. Although LZP and its analogs exhibited similar permeability, secondary structures, and localization in negatively charged membranes, significant differences were observed among these peptides in zwitterionic membranes. The results suggest a novel approach for designing antibacterial peptides with modulation of toxicity against hRBCs by employing the leucine zipper sequence. Also, to the best of our knowledge, the results demonstrate that this sequence could be utilized to design novel cell-selective molecules for the first time.

  20. Design of a titering assay for lentiviral vectors utilizing direct extraction of DNA from transduced cells in microtiter plates

    Directory of Open Access Journals (Sweden)

    Michele E Murphy

    2016-01-01

    Full Text Available Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the number of vector DNA copies in transduced target cells, from which a transduction titer is calculated. Immune Design previously described an integration-deficient lentiviral vector pseudotyped with a modified Sindbis virus envelope for use in cancer immunotherapy (VP02, of the ZVex platform. Standard protocols for titering integration-competent lentiviral vectors employ commercial spin columns to purify vector DNA from transduced cells, but such columns are not optimized for isolation of extrachromosomal (nonintegrated DNA. Here, we describe a 96-well transduction titer assay in which DNA extraction is performed in situ in the transduction plate, yielding quantitative recovery of extrachromosomal DNA. Vector titers measured by this method were higher than when commercial spin columns were used for DNA isolation. Evaluation of the method's specificity, linear range, and precision demonstrate that it is suitable for use as a lot release assay to support clinical trials with VP02. Finally, the method is compatible with titering both integrating and nonintegrating lentiviral vectors, suggesting that it may be used to evaluate the transduction titer for any lentiviral vector.

  1. Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study).

    Science.gov (United States)

    Gulliford, Martin C; van Staa, Tjeerd P; McDermott, Lisa; McCann, Gerard; Charlton, Judith; Dregan, Alex

    2014-06-11

    research governance approval and intervention implementation. Pretrial data analyses should inform trial design and analysis plans. Current Controlled Trials ISRCTN 47558792 and ISRCTN 35701810 (both registered on 17 March 2010).

  2. Auditory Imagery: Empirical Findings

    Science.gov (United States)

    Hubbard, Timothy L.

    2010-01-01

    The empirical literature on auditory imagery is reviewed. Data on (a) imagery for auditory features (pitch, timbre, loudness), (b) imagery for complex nonverbal auditory stimuli (musical contour, melody, harmony, tempo, notational audiation, environmental sounds), (c) imagery for verbal stimuli (speech, text, in dreams, interior monologue), (d)…

  3. Essays in empirical microeconomics

    NARCIS (Netherlands)

    Péter, A.N.

    2016-01-01

    The empirical studies in this thesis investigate various factors that could affect individuals' labor market, family formation and educational outcomes. Chapter 2 focuses on scheduling as a potential determinant of individuals' productivity. Chapter 3 looks at the role of a family factor on

  4. Empirically sampling Universal Dependencies

    DEFF Research Database (Denmark)

    Schluter, Natalie; Agic, Zeljko

    2017-01-01

    Universal Dependencies incur a high cost in computation for unbiased system development. We propose a 100% empirically chosen small subset of UD languages for efficient parsing system development. The technique used is based on measurements of model capacity globally. We show that the diversity o...

  5. Empirical Music Aesthetics

    DEFF Research Database (Denmark)

    Grund, Cynthia M.

    musical performance and reception is inspired by traditional approaches within aesthetics, but it also challenges some of the presuppositions inherent in them. As an example of such work I present a research project in empirical music aesthetics begun last year and of which I am a team member....

  6. Empirical research and logotherapy.

    Science.gov (United States)

    Schulenberg, Stefan E

    2003-08-01

    The purpose of this paper was to outline suggestions for future logotherapy applications and research. Empirical studies are available on logotherapy constructs, but additional research is sorely needed. The psychometrics of logotherapy measures need to be expanded. Carefully conducted experimental studies may aid in refining long-standing logotherapy concepts and supporting or refuting new ones.

  7. Gazprom: the new empire

    International Nuclear Information System (INIS)

    Guillemoles, A.; Lazareva, A.

    2008-01-01

    Gazprom is conquering the world. The Russian industrial giant owns the hugest gas reserves and enjoys the privilege of a considerable power. Gazprom edits journals, owns hospitals, airplanes and has even built cities where most of the habitants work for him. With 400000 workers, Gazprom represents 8% of Russia's GDP. This inquiry describes the history and operation of this empire and show how its has become a masterpiece of the government's strategy of russian influence reconquest at the world scale. Is it going to be a winning game? Are the corruption affairs and the expected depletion of resources going to weaken the empire? The authors shade light on the political and diplomatic strategies that are played around the crucial dossier of the energy supply. (J.S.)

  8. Empires, Modernisation and Modernities

    Directory of Open Access Journals (Sweden)

    Tony Ballantyne

    2014-11-01

    Full Text Available In examining four recent books, this essay explores some key facets of contemporary scholarship on empire and the making of the modern world. Drawing on Dipesh Chakrabarty’s arguments about the often contingent relationship between modernisation as a set of material and institutional transformations and modernity as a cultural sensibility, it argues that the unfolding of the modern was messy, uneven, and remained in process until the age of decolonisation. The essay suggests that the range of modern formations that emerged out of empire-building were profoundly imprinted by local socio-political patterns and the weight of precolonial cultural traditions, meaning that modernisation never played out as an entirely homogenising force.

  9. Essays in empirical microeconomics

    OpenAIRE

    Péter, A.N.

    2016-01-01

    This dissertation is comprised of three papers using empirical methods to study issues in public and social economics. My first paper, co-authored with Julian Betts, analyzes the performance of San Diego's charter schools using fixed-effect methods on panel student data. We find that charter school performance in San Diego varies by subject matter, grades served, school type and years of operation. In many cases, we find that charter school performance is indistinguishable from that of tradit...

  10. Trade and Empire

    DEFF Research Database (Denmark)

    Bang, Peter Fibiger

    2007-01-01

    This articles seeks to establish a new set of organizing concepts for the analysis of the Roman imperial economy from Republic to late antiquity: tributary empire, port-folio capitalism and protection costs. Together these concepts explain better economic developments in the Roman world than the ...... much used notion of an imperial market economy.  Roman imperial government was to weak to provide the institutional supports needed by a well functioning laissez-faire economy....

  11. Advancing empirical resilience research.

    Science.gov (United States)

    Kalisch, Raffael; Müller, Marianne B; Tüscher, Oliver

    2015-01-01

    We are delighted by the broad, intense, and fruitful discussion in reaction to our target article. A major point we take from the many comments is a prevailing feeling in the research community that we need significantly and urgently to advance resilience research, both by sharpening concepts and theories and by conducting empirical studies at a much larger scale and with a much more extended and sophisticated methodological arsenal than is the case currently. This advancement can be achieved only in a concerted international collaborative effort. In our response, we try to argue that an explicitly atheoretical, purely observational definition of resilience and a transdiagnostic, quantitative study framework can provide a suitable basis for empirically testing different competing resilience theories (sects. R1, R2, R6, R7). We are confident that it should be possible to unite resilience researchers from different schools, including from sociology and social psychology, behind such a pragmatic and theoretically neutral research strategy. In sections R3 to R5, we further specify and explain the positive appraisal style theory of resilience (PASTOR). We defend PASTOR as a comparatively parsimonious and translational theory that makes sufficiently concrete predictions to be evaluated empirically.

  12. Design and performance of a matrix-assisted laser desorption time-of-flight mass spectrometer utilizing a pulsed nitrogen laser

    International Nuclear Information System (INIS)

    Brown, R.S.; Gilfrich, N.L.

    1991-01-01

    The design considerations and experimental performance of a linear time-of-flight mass spectrometer are reported for performing matrix-assisted laser desorption studies. A simple pulsed gas-discharge nitrogen laser (337.1 nm) is successfully used in contrast to the more widely used frequency-quadrupled (266 nm) or frequency-tripled (355 nm) Nd:YAG solid-state laser. Optical considerations in utilizing the pulsed nitrogen laser are discussed and a simple optical arrangement is described which allows for suitable imaging of the poor spatial beam profile of the pulsed nitrogen laser. Laser spot sizes of 150x450 μm are obtainable. As with the frequency-tripled Nd:YAG laser, sinapic acid is found to be the most useful matrix for producing protonated molecular species from proteins. Appropriate laser power levels are determined, as matrix/sample levels. Adequate response for most small to medium molecular weight proteins is obtained for less than 1 pmol of sample. A simple einsel lens incorporated into the ion source does not appear to provide any significant focusing on the laser-desorbed ions; however, a constant d.c. voltage applied to beam stirring plates enhances the ion signal significantly. Selective, pulsed deflection of the low-mass ions produced from the matrix is also utilized to prevent excessive saturation of the microchannel plate ion detector. High source potentials are found to provide improved resolution and sensitivity in comparison with lower source potentials combined with post-acceleration at the detector. Representative mass spectra of several proteins and peptides are presented. Increased formation of photoinduced adduct ions are observed in comparison with that reported for matrix-assisted laser desorption experiments utilizing a Nd:YAG laser and significant amounts of dimer and trimer ions are produced. Significantly more peak broadening than would normally be expected is observed above 20000 u. This may be due to the post-acceleration design of

  13. Alternative Approaches to Evaluation in Empirical Microeconomics

    Science.gov (United States)

    Blundell, Richard; Dias, Monica Costa

    2009-01-01

    This paper reviews some of the most popular policy evaluation methods in empirical microeconomics: social experiments, natural experiments, matching, instrumental variables, discontinuity design, and control functions. It discusses identification of traditionally used average parameters and more complex distributional parameters. The adequacy,…

  14. Ideal Point Design and Operation of CO2-Based Transcritical Rankine Cycle (CTRC System Based on High Utilization of Engine’s Waste Heats

    Directory of Open Access Journals (Sweden)

    Lingfeng Shi

    2017-10-01

    Full Text Available This research conducted a study specially to systematically analyze combined recovery of exhaust gas and engine coolant and related influence mechanism, including a detailed theoretical study and an assistant experimental study. In this research, CO2-based transcritical Rankine cycle (CTRC was used for fully combining the wastes heats. The main objective of theoretical research was to search an ‘ideal point’ of the recovery system and related influence mechanism, which was defined as operating condition of complete recovery of two waste heats. The theoretical methodology of this study could also provide a design reference for effective combined recovery of two or multiple waste heats in other fields. Based on a kW-class preheated CTRC prototype that was designed by the ‘ideal point’ method, an experimental study was conducted to verify combined utilization degree of two engine waste heats by the CTRC system. The operating results showed that the prototype can gain 44.4–49.8 kW and 22.7–26.7 kW heat absorption from exhaust gas and engine coolant, respectively. To direct practical operation, an experimental optimization work on the operating process was conducted for complete recovery of engine coolant exactly, which avoided deficient or excessive recovery.

  15. Empirical Study Utilizing QFD to Develop an International Marketing Strategy

    Directory of Open Access Journals (Sweden)

    Cassandra Elrod

    2015-08-01

    Full Text Available Customer expectations can be extremely nebulous. This research identifies the demographic segmentations and their respective expectations for the spa market. Interviews were conducted and a subsequent questionnaire was employed to gather the voice of the customer and assess the expectations of spa clientele. All of the data was collected from luxury spas in Hawaii, and consisted of respondents from all over the world. Results of the survey suggest that while men want more tangible benefits of a spa, women prefer the experiential qualities of peace and rejuvenation. Additionally, those of lower to middle income focus on the atmosphere more than wealthier clients, who are looking for more long term spa benefits, such as a more youthful appearance.

  16. Empirical evaluation methods in computer vision

    CERN Document Server

    Christensen, Henrik I

    2002-01-01

    This book provides comprehensive coverage of methods for the empirical evaluation of computer vision techniques. The practical use of computer vision requires empirical evaluation to ensure that the overall system has a guaranteed performance. The book contains articles that cover the design of experiments for evaluation, range image segmentation, the evaluation of face recognition and diffusion methods, image matching using correlation methods, and the performance of medical image processing algorithms. Sample Chapter(s). Foreword (228 KB). Chapter 1: Introduction (505 KB). Contents: Automate

  17. Focus Group Evidence: Implications for Design and Analysis

    Science.gov (United States)

    Ryan, Katherine E.; Gandha, Tysza; Culbertson, Michael J.; Carlson, Crystal

    2014-01-01

    In evaluation and applied social research, focus groups may be used to gather different kinds of evidence (e.g., opinion, tacit knowledge). In this article, we argue that making focus group design choices explicitly in relation to the type of evidence required would enhance the empirical value and rigor associated with focus group utilization. We…

  18. Epistemology and Empirical Investigation

    DEFF Research Database (Denmark)

    Ahlström, Kristoffer

    2008-01-01

    Recently, Hilary Kornblith has argued that epistemological investigation is substantially empirical. In the present paper, I will ¿rst show that his claim is not contingent upon the further and, admittedly, controversial assumption that all objects of epistemological investigation are natural kinds....... Then, I will argue that, contrary to what Kornblith seems to assume, this methodological contention does not imply that there is no need for attending to our epistemic concepts in epistemology. Understanding the make-up of our concepts and, in particular, the purposes they ¿ll, is necessary...

  19. Epistemology and Empirical Investigation

    DEFF Research Database (Denmark)

    Ahlström, Kristoffer

    2008-01-01

    Recently, Hilary Kornblith has argued that epistemological investigation is substantially empirical. In the present paper, I will ¿rst show that his claim is not contingent upon the further and, admittedly, controversial assumption that all objects of epistemological investigation are natural kinds....... Then, I will argue that, contrary to what Kornblith seems to assume, this methodological contention does not imply that there is no need for attending to our epistemic concepts in epistemology. Understanding the make-up of our concepts and, in particular, the purposes they ¿ll, is necessary...... for a proper acknowledgment of epistemology’s role in conceptual improvement...

  20. Defining the effect and mediators of two knowledge translation strategies designed to alter knowledge, intent and clinical utilization of rehabilitation outcome measures: a study protocol [NCT00298727

    Directory of Open Access Journals (Sweden)

    Law Mary

    2006-07-01

    Full Text Available Abstract Background A substantial number of valid outcome measures have been developed to measure health in adult musculoskeletal and childhood disability. Regrettably, national initiatives have merely resulted in changes in attitude, while utilization remains unacceptably low. This study will compare the effectiveness and mediators of two different knowledge transfer (KT interventions in terms of their impact on changing knowledge and behavior (utilization and clinical reasoning related to health outcome measures. Method/Design Physical and occupational therapists (n = 144 will be recruited in partnership with the national professional associations to evaluate two different KT interventions with the same curriculum: 1 Stakeholder-Hosted Interactive Problem-Based Seminar (SHIPS, and 2 Online Problem-Based course (e-PBL. SHIPS will consist of face-to-face problem-based learning (PBL for 2 1/2 days with outcome measure developers as facilitators, using six problems generated in consultation with participants. The e-PBL will consist of a 6-week web-based course with six generic problems developed by content experts. SHIPS will be conducted in three urban centers in Canada. Participants will be block-allocated by a minimization procedure to either of the two interventions to minimize any prognostic differences. Trained evaluators at each site will conduct chart audits and chart-stimulated recall. Trained interviewers will conduct semi-structured interviews focused on identifying critical elements in KT and implementing practice changes. Interviews will be transcribed verbatim. Baseline predictors including demographics, knowledge, attitudes/barriers regarding outcome measures, and Readiness to Change will be assessed by self-report. Immediately post-intervention and 6 months later, these will be re-administered. Primary qualitative and quantitative evaluations will be conducted 6-months post-intervention to assess the relative effectiveness of KT

  1. Empirical microeconomics action functionals

    Science.gov (United States)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  2. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    This publication is unique in its demystification and operationalization of the complex and elusive nature of the design process. The publication portrays the designer’s daily work and the creative process, which the designer is a part of. Apart from displaying the designer’s work methods...... and design parameters, the publication shows examples from renowned Danish design firms. Through these examples the reader gets an insight into the designer’s reality....

  3. What 'empirical turn in bioethics'?

    Science.gov (United States)

    Hurst, Samia

    2010-10-01

    Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the 'empirical turn' in bioethics. This article examines three different ways in which we could understand 'empirical turn'. Using real facts in normative reasoning is trivial and would not represent a 'turn'. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term 'empirical turn'. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact-value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.

  4. A REVIEW of WEBERIAN STUDIES ON THE OTTOMAN EMPIRE

    OpenAIRE

    MAZMAN, İbrahim

    2018-01-01

    This study examines the secondary literature on Max Weber’s (1864-1920) writings onIslam and the Ottoman Empire. It demarcates approaches prevalent in the secondaryliterature. Three basic themes are apparent:- Section a) concentrates on authors who applied Weber’s concepts of patrimonialism andbureaucracy to non-Ottoman countries, such as Maslovski (on the Soviet bureaucracy)and Eisenberg (on China).- Section b) focuses on authors who studied the Ottoman Empire utilizing non-Weberianaboveall ...

  5. Five-year examination of utilization and drug cost outcomes associated with benefit design changes including reference pricing for proton pump inhibitors in a state employee health plan.

    Science.gov (United States)

    Johnson, Jill T; Neill, Kathryn K; Davis, Dwight A

    2011-04-01

    The Arkansas State Employee Benefits Division (EBD) is a self-insured program comprising public school and other state employees, their spouses, and dependents. Previous research published in JMCP (2006) showed drug cost savings of $2.20 per member per month (PMPM; 37.6%) or annualized savings of $3.4 million associated with a benefit design change and coverage of the proton pump inhibitor (PPI) omeprazole over-the-counter (OTC) beginning in March 2004. On May 1, 2005, brand esomeprazole was excluded from coverage, with current users grandfathered for 4 months until September 2005. Reference pricing for PPIs, including esomeprazole but excluding generic omeprazole, was implemented on September 1, 2005, and the beneficiary cost share for all PPIs except generic omeprazole was determined from comparison of the PPI actual price to the $0.90 omeprazole OTC reference price per unit. To examine PPI utilization and drug costs before and after (a) excluding esomeprazole from coverage (with grandfathering current users) and (b) implementing a therapeutic maximum allowable cost (TMAC), or reference-pricing benefit design, for the PPI class in a large state employee health plan with fairly stable enrollment of approximately 127,500 members in 2005 through 2008 and approximately 128,000 members in 2009 Q1. The pharmacy claims database for the EBD was used to examine utilization and cost data for PPIs in a longitudinal analysis for the 61-month period from March 1, 2004, through March 31, 2009. Pharmacy claims data were compared for the period 14 months prior to esomeprazole exclusion (preperiod), 4 months during the esomeprazole exclusion (postperiod 1), and the ensuing 43 months of PPI reference pricing (postperiod 2). PPI cost and utilization data for the intervention group of approximately 127,500 beneficiaries were compared with a group of 122 self-insured employers with a total of nearly 1 million beneficiaries whose pharmacy benefits did not include reference pricing for

  6. Civilization and Empire

    DEFF Research Database (Denmark)

    Suzuki, Shogo

    China and Japan engaged with this dualism, this book highlights a darker side of China and Japan’s socialization into International Society which previous studies have failed to acknowledge. Drawing on Chinese and Japanese primary sources seldom utilized in International Relations, this book makes...

  7. Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.

    Science.gov (United States)

    Agarabi, Cyrus D; Chavez, Brittany K; Lute, Scott C; Read, Erik K; Rogstad, Sarah; Awotwe-Otoo, David; Brown, Matthew R; Boyne, Michael T; Brorson, Kurt A

    2017-01-01

    Linkage of upstream cell culture with downstream processing and purification is an aspect of Quality by Design crucial for efficient and consistent production of high quality biopharmaceutical proteins. In a previous Plackett-Burman screening study of parallel bioreactor cultures we evaluated main effects of 11 process variables, such as agitation, sparge rate, feeding regimens, dissolved oxygen set point, inoculation density, supplement addition, temperature, and pH shifts. In this follow-up study, we observed linkages between cell culture process parameters and downstream capture chromatography performance and subsequent antibody attributes. In depth analysis of the capture chromatography purification of harvested cell culture fluid yielded significant effects of upstream process parameters on host cell protein abundance and behavior. A variety of methods were used to characterize the antibody both after purification and buffer formulation. This analysis provided insight in to the significant impacts of upstream process parameters on aggregate formation, impurities, and protein structure. This report highlights the utility of linkage studies in identifying how changes in upstream parameters can impact downstream critical quality attributes. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:163-170, 2017. © 2016 American Institute of Chemical Engineers.

  8. Land 3D-seismic data: Preprocessing quality control utilizing survey design specifications, noise properties, normal moveout, first breaks, and offset

    Science.gov (United States)

    Raef, A.

    2009-01-01

    The recent proliferation of the 3D reflection seismic method into the near-surface area of geophysical applications, especially in response to the emergence of the need to comprehensively characterize and monitor near-surface carbon dioxide sequestration in shallow saline aquifers around the world, justifies the emphasis on cost-effective and robust quality control and assurance (QC/QA) workflow of 3D seismic data preprocessing that is suitable for near-surface applications. The main purpose of our seismic data preprocessing QC is to enable the use of appropriate header information, data that are free of noise-dominated traces, and/or flawed vertical stacking in subsequent processing steps. In this article, I provide an account of utilizing survey design specifications, noise properties, first breaks, and normal moveout for rapid and thorough graphical QC/QA diagnostics, which are easy to apply and efficient in the diagnosis of inconsistencies. A correlated vibroseis time-lapse 3D-seismic data set from a CO2-flood monitoring survey is used for demonstrating QC diagnostics. An important by-product of the QC workflow is establishing the number of layers for a refraction statics model in a data-driven graphical manner that capitalizes on the spatial coverage of the 3D seismic data. ?? China University of Geosciences (Wuhan) and Springer-Verlag GmbH 2009.

  9. Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

    Science.gov (United States)

    Yasui, Takeshi; Yamamoto, Takeshi; Sakai, Nozomu; Asano, Kouhei; Takai, Takafumi; Yoshitomi, Yayoi; Davis, Melinda; Takagi, Terufumi; Sakamoto, Kotaro; Sogabe, Satoshi; Kamada, Yusuke; Lane, Weston; Snell, Gyorgy; Iwata, Masashi; Goto, Masayuki; Inooka, Hiroshi; Sakamoto, Jun-Ichi; Nakada, Yoshihisa; Imaeda, Yasuhiro

    2017-09-01

    B-cell lymphoma 6 (BCL6) is a transcriptional repressor that can form complexes with corepressors via protein-protein interactions (PPIs). The complexes of BCL6 and corepressors play an important role in the formation of germinal centers (GCs), and differentiation and proliferation of lymphocytes. Therefore, BCL6-corepressor interaction inhibitors would be drug candidates for managing autoimmune diseases and cancer. Starting from high-throughput screening hits 1a and 2a, we identified a novel BCL6-corepressor interaction inhibitor 8c (cell-free enzyme-linked immunosorbent assay [ELISA] IC 50 =0.10µM, cell-based mammalian two-hybrid [M2H] assay IC 50 =0.72µM) by utilizing structure-based drug design (SBDD) based on an X-ray crystal structure of 1a bound to BCL6. Compound 8c also showed a good pharmacokinetic profile, which was acceptable for both in vitro and in vivo studies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Collyria seals in the Roman Empire.

    Science.gov (United States)

    Perez-Cambrodi, Rafael J; Pinero, David P; Mavrou, Ariadni; Cervino, Alejandro; Brautaset, Rune; Murube del Castillo, Juan

    2013-01-01

    Roman seals associated with collyria (Latin expression for eye drops/washes and lotions for eye maintenance) provide valuable information about eye care in the antiquity. These small, usually stone-made pieces bore engravings with the names of eye doctors and also the collyria used to treat an eye disease. The collyria seals have been found all over the Roman empire and Celtic territories in particular and were usually associated with military camps. In Hispania (Iberian Peninsula), only three collyria seals have been found. These findings speak about eye care in this ancient Roman province as well as about of the life of the time. This article takes a look at the utility and social significance of the collyria seals and seeks to give an insight in the ophthalmological practice of in the Roman Empire.

  11. A Systematic Assessment of Empirical Research on Foreign Entry Mode

    DEFF Research Database (Denmark)

    Wulff, Jesper

    2016-01-01

    Purpose Reviews on foreign market entry mode are limited by their methodological approach. The purpose of this paper is to overcome some of these limitations by systematically assessing the empirical support for central relationships in the empirical literature. Design/methodology/approach This r......Purpose Reviews on foreign market entry mode are limited by their methodological approach. The purpose of this paper is to overcome some of these limitations by systematically assessing the empirical support for central relationships in the empirical literature. Design....../methodology/approach This review provides a systematic assessment of empirical support through a simple quantitative procedure using transparent criteria for article selection. In total, 1217 statistical tests from 119 studies published in 44 different scientific journals in the period 1997-2013 are examined across a range...

  12. Empirical techniques in finance

    CERN Document Server

    Bhar, Ramaprasad

    2005-01-01

    This book offers the opportunity to study and experience advanced empi- cal techniques in finance and in general financial economics. It is not only suitable for students with an interest in the field, it is also highly rec- mended for academic researchers as well as the researchers in the industry. The book focuses on the contemporary empirical techniques used in the analysis of financial markets and how these are implemented using actual market data. With an emphasis on Implementation, this book helps foc- ing on strategies for rigorously combing finance theory and modeling technology to extend extant considerations in the literature. The main aim of this book is to equip the readers with an array of tools and techniques that will allow them to explore financial market problems with a fresh perspective. In this sense it is not another volume in eco- metrics. Of course, the traditional econometric methods are still valid and important; the contents of this book will bring in other related modeling topics tha...

  13. Human Power Empirically Explored

    NARCIS (Netherlands)

    Jansen, A.J.

    2011-01-01

    Harvesting energy from the users’ muscular power to convert this into electricity is a relatively unknown way to power consumer products. It nevertheless offers surprising opportunities for product designers; human-powered products function independently from regular power infrastructure, are

  14. Estimating Utility

    DEFF Research Database (Denmark)

    Arndt, Channing; Simler, Kenneth R.

    2010-01-01

    A fundamental premise of absolute poverty lines is that they represent the same level of utility through time and space. Disturbingly, a series of recent studies in middle- and low-income economies show that even carefully derived poverty lines rarely satisfy this premise. This article proposes...... an information-theoretic approach to estimating cost-of-basic-needs (CBN) poverty lines that are utility consistent. Applications to date illustrate that utility-consistent poverty measurements derived from the proposed approach and those derived from current CBN best practices often differ substantially......, with the current approach tending to systematically overestimate (underestimate) poverty in urban (rural) zones....

  15. Final Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one....

  16. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  17. Remembrances of Empires Past

    Directory of Open Access Journals (Sweden)

    Robert Aldrich

    2010-05-01

    Full Text Available This paper argues that the colonial legacy is ever present in contemporary Europe. For a generation, most Europeans largely tried, publicly, to forget the colonial past, or remembered it only through the rose-coloured lenses of nostalgia; now the pendulum has swung to memory of that past – even perhaps, in the views of some, to a surfeit of memory, where each group agitates for its own version of history, its own recognition in laws and ceremonies, its own commemoration in museums and monuments, the valorization or repatriation of its own art and artefacts. Word such as ‘invasion,’ ‘racism’ and ‘genocide’ are emotional terms that provoke emotional reactions. Whether leaders should apologize for wrongs of the past – and which wrongs – remains a highly sensitive issue. The ‘return of the colonial’ thus has to do with ethics and politics as well as with history, and can link to statements of apology or recognition, legislation about certain views of history, monetary compensation, repatriation of objects, and—perhaps most importantly—redefinition of national identity and policy. The colonial flags may have been lowered, but many barricades seem to have been raised. Private memories—of loss of land, of unacknowledged service, of political, economic, social and cultural disenfranchisement, but also on the other side of defeat, national castigation and self-flagellation—have been increasingly public. Monuments and museums act not only as sites of history but as venues for political agitation and forums for academic debate – differences of opinion that have spread to the streets. Empire has a long after-life.

  18. A process approach to the utility for gambling

    OpenAIRE

    Marc Le Menestrel

    2001-01-01

    This paper argues that any specific utility or disutility for gambling must be excluded from expected utility because such a theory is consequential while a pleasure or displeasure for gambling is a matter of process, not of consequences. A (dis)utility for gambling is modeled as a process utility which monotonically combines with expected utility restricted to consequences. This allows for a process (dis)utility for gambling to be revealed. As an illustration, the model shows how empirical o...

  19. Design

    DEFF Research Database (Denmark)

    Volf, Mette

    Design - proces & metode iBog®  er enestående i sit fokus på afmystificering og operationalisering af designprocessens flygtige og komplekse karakter. Udgivelsen går bag om designerens daglige arbejde og giver et indblik i den kreative skabelsesproces, som designeren er en del af. Udover et bredt...... indblik i designerens arbejdsmetoder og designparametre giver Design - proces & metode en række eksempler fra anerkendte designvirksomheder, der gør det muligt at komme helt tæt på designerens virkelighed....

  20. Empirical Support for Perceptual Conceptualism

    Directory of Open Access Journals (Sweden)

    Nicolás Alejandro Serrano

    2018-03-01

    Full Text Available The main objective of this paper is to show that perceptual conceptualism can be understood as an empirically meaningful position and, furthermore, that there is some degree of empirical support for its main theses. In order to do this, I will start by offering an empirical reading of the conceptualist position, and making three predictions from it. Then, I will consider recent experimental results from cognitive sciences that seem to point towards those predictions. I will conclude that, while the evidence offered by those experiments is far from decisive, it is enough not only to show that conceptualism is an empirically meaningful position but also that there is empirical support for it.

  1. An Empirical Mass Function Distribution

    Science.gov (United States)

    Murray, S. G.; Robotham, A. S. G.; Power, C.

    2018-03-01

    The halo mass function, encoding the comoving number density of dark matter halos of a given mass, plays a key role in understanding the formation and evolution of galaxies. As such, it is a key goal of current and future deep optical surveys to constrain the mass function down to mass scales that typically host {L}\\star galaxies. Motivated by the proven accuracy of Press–Schechter-type mass functions, we introduce a related but purely empirical form consistent with standard formulae to better than 4% in the medium-mass regime, {10}10{--}{10}13 {h}-1 {M}ȯ . In particular, our form consists of four parameters, each of which has a simple interpretation, and can be directly related to parameters of the galaxy distribution, such as {L}\\star . Using this form within a hierarchical Bayesian likelihood model, we show how individual mass-measurement errors can be successfully included in a typical analysis, while accounting for Eddington bias. We apply our form to a question of survey design in the context of a semi-realistic data model, illustrating how it can be used to obtain optimal balance between survey depth and angular coverage for constraints on mass function parameters. Open-source Python and R codes to apply our new form are provided at http://mrpy.readthedocs.org and https://cran.r-project.org/web/packages/tggd/index.html respectively.

  2. Design

    Science.gov (United States)

    Buchanan, Richard; Cross, Nigel; Durling, David; Nelson, Harold; Owen, Charles; Valtonen, Anna; Boling, Elizabeth; Gibbons, Andrew; Visscher-Voerman, Irene

    2013-01-01

    Scholars representing the field of design were asked to identify what they considered to be the most exciting and imaginative work currently being done in their field, as well as how that work might change our understanding. The scholars included Richard Buchanan, Nigel Cross, David Durling, Harold Nelson, Charles Owen, and Anna Valtonen. Scholars…

  3. Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Pettiway, Keon

    2017-01-01

    In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions by desig......In this chapter, Ole B. Jensen takes a situational approach to mobilities to examine how ordinary life activities are structured by technology and design. Using “staging mobilities” as a theoretical approach, Jensen considers mobilities as overlapping, actions, interactions and decisions...... by designers, planners, etc. (staging from above) and mobile subjects (staging from below). A research agenda for studying situated practices of mobility and mobilities design is outlined in three directions: foci of studies, methods and approaches, and epistemologies and frames of thinking. Jensen begins...... with a brief description of how movement is studied within social sciences after the “mobilities turn” versus the idea of physical movement in transport geography and engineering. He then explains how “mobilities design” was derived from connections between traffic and architecture. Jensen concludes...

  4. Development for environmentally friendly and highly efficient energy utilization system in fiscal 1998. Pt. 3. Research on highly efficient and effective energy utilization technology (Research on design technology for optimal system); 1998 nendo kankyo chowagata kokoritsu energy riyo system kaihatsu. 3. Kokoritsu energy yuko riyo gijutsu no kenkyu (saiteki system sekkei gijutsu no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    This paper summarizes achievements during fiscal 1998 on researching part of the energy transportation and storage technologies, energy supply and utilization technologies, environmental load reducing technologies, and optimal system design in the 'research on highly efficient and effective energy utilization technology'. With regard to energy transportation and storage technologies, researches and developments were performed on a vacuum adiabatic transportation piping system, surfactants used for high-density heat transportation and high-density latent heat transportation technologies. In the field of energy supply and utilization technologies, researches and developments were carried out on a heat supply system using high-performance heat pumps capable of using multiple kinds of fuels, and a compression and absorption type hybrid heat utilization system. For the environmental load reducing technologies, research and development were performed on a power saving heat pump system utilizing natural coolant. In researching the optimal system design technologies, overall adjustment was made on the element technologies, whereas technological discussions and site surveys were executed by the committees at the same time. The latest achievements accomplished to date was published in a book. (NEDO)

  5. Birds of the Mongol Empire

    Directory of Open Access Journals (Sweden)

    Eugene N. Anderson

    2016-09-01

    Full Text Available The Mongol Empire, the largest contiguous empire the world has ever known, had, among other things, a goodly number of falconers, poultry raisers, birdcatchers, cooks, and other experts on various aspects of birding. We have records of this, largely in the Yinshan Zhengyao, the court nutrition manual of the Mongol empire in China (the Yuan Dynasty. It discusses in some detail 22 bird taxa, from swans to chickens. The Huihui Yaofang, a medical encyclopedia, lists ten taxa used medicinally. Marco Polo also made notes on Mongol bird use. There are a few other records. This allows us to draw conclusions about Mongol ornithology, which apparently was sophisticated and detailed.

  6. Development and problems on concrete technology in Thailand. Effort toward performance-based design and wastes utilization; Tai ni okeru konkurito gijutsu no katten to kongo no mondai. Seino shosagata sekkei to haikibutsu no riyo eno torikumi

    Energy Technology Data Exchange (ETDEWEB)

    Somnuk, Tangtermsirikul [University Thailand, Bangkok (Thailand)

    1999-03-10

    They explained economic crisis and development trend of concrete technology of Thailand in the back and future problem. They introduced growth (GNP) of the economy from 1989 to 1998, growth of the construction business and the cement production quantity and the cement consumption of the interval. In addition, as a design concept of concreting material, they introduced the utilization of the natural and artificial pozzolans (fly ash, steel slag, silica fume, pumice, metakaolin, etc.) as a utilization of a waste to the concrete, when they considered property and strength of the concrete suitable for the climate of Thailand, and they introduced strength of the concrete using these, etc.. (NEDO)

  7. Empirical Legality and Effective Reality

    Directory of Open Access Journals (Sweden)

    Hernán Pringe

    2015-08-01

    Full Text Available The conditions that Kant’s doctrine establishes are examined for the predication of the effective reality of certain empirical objects. It is maintained that a for such a predication, it is necessary to have not only perception but also a certain homogeneity of sensible data, and b the knowledge of the existence of certain empirical objects depends on the application of regulative principles of experience.

  8. High School Student Perceptions of the Utility of the Engineering Design Process: Creating Opportunities to Engage in Engineering Practices and Apply Math and Science Content

    Science.gov (United States)

    Berland, Leema; Steingut, Rebecca; Ko, Pat

    2014-12-01

    Research and policy documents increasingly advocate for incorporating engineering design into K-12 classrooms in order to accomplish two goals: (1) provide an opportunity to engage with science content in a motivating real-world context; and (2) introduce students to the field of engineering. The present study uses multiple qualitative data sources (i.e., interviews, artifact analysis) in order to examine the ways in which engaging in engineering design can support students in participating in engineering practices and applying math and science knowledge. This study suggests that students better understand and value those aspects of engineering design that are more qualitative (i.e., interviewing users, generating multiple possible solutions) than the more quantitative aspects of design which create opportunities for students to integrate traditional math and science content into their design work (i.e., modeling or systematically choosing between possible design solutions). Recommendations for curriculum design and implementation are discussed.

  9. Risk and utility in portfolio optimization

    Science.gov (United States)

    Cohen, Morrel H.; Natoli, Vincent D.

    2003-06-01

    Modern portfolio theory (MPT) addresses the problem of determining the optimum allocation of investment resources among a set of candidate assets. In the original mean-variance approach of Markowitz, volatility is taken as a proxy for risk, conflating uncertainty with risk. There have been many subsequent attempts to alleviate that weakness which, typically, combine utility and risk. We present here a modification of MPT based on the inclusion of separate risk and utility criteria. We define risk as the probability of failure to meet a pre-established investment goal. We define utility as the expectation of a utility function with positive and decreasing marginal value as a function of yield. The emphasis throughout is on long investment horizons for which risk-free assets do not exist. Analytic results are presented for a Gaussian probability distribution. Risk-utility relations are explored via empirical stock-price data, and an illustrative portfolio is optimized using the empirical data.

  10. The Blooming Anatomy Tool (BAT): A Discipline-Specific Rubric for Utilizing Bloom's Taxonomy in the Design and Evaluation of Assessments in the Anatomical Sciences

    Science.gov (United States)

    Thompson, Andrew R.; O'Loughlin, Valerie D.

    2015-01-01

    Bloom's taxonomy is a resource commonly used to assess the cognitive level associated with course assignments and examination questions. Although widely utilized in educational research, Bloom's taxonomy has received limited attention as an analytical tool in the anatomical sciences. Building on previous research, the Blooming Anatomy Tool (BAT)…

  11. Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture.

    Science.gov (United States)

    Baur, Daniel; Angarita, Monica; Müller-Späth, Thomas; Morbidelli, Massimo

    2016-01-01

    Multi-column chromatographic processes have recently been developed for protein A affinity chromatography to efficiently capture monoclonal antibodies from cell culture supernatant. In this work, the novel twin-column CaptureSMB process was compared to a batch capture process with dual loading flow rate to identify performance gains. As a case study, the isolation of a monoclonal antibody with the Amsphere JWT-203 protein A resin was investigated. Using model based optimization, both processes were optimized and compared over a wide range of operating conditions. A trade-off between productivity and capacity utilization was found, and the resulting pareto-curves showed that CaptureSMB dominates batch, except at very low productivity values. With a feed titer of 1.2 mg mL(-1) , CaptureSMB could reach a productivity of up to 19.5 mg mL(-1) h(-1) experimentally, while maintaining relatively high capacity utilization of 63.8%. On the other hand, at maximum capacity utilization of 95.5%, a productivity of 10.2 mg mL(-1) h(-1) could be reached. This corresponds to a performance improvement with respect batch operation of about 25% in capacity utilization and 40% in productivity, for given yield and purity. CaptureSMB therefore offers a greatly increased performance over batch capture. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Customer satisfaction from private utility companies: An explanatory study

    Directory of Open Access Journals (Sweden)

    Eleni-Plousia Kosteroglou

    2016-12-01

    Full Text Available Purpose – The present study examines the factors that have an impact on "customer satisfaction" in the context of private utility companies. The main purpose of the study is accomplished through the development and the empirical testing of a conceptual frame-work (research model. The proposed framework includes six dimensions (research factors: (a tangibles, (b reliability, (c responsiveness, (d assurance, (e empathy, and (f customer satisfaction. Design/methodology/approach – The present study adopted the SERVQUAL approach (model, only after analytically testing its suitability for use within the investigated area. In that direction, the focus group methodology was used. Finally, the proposed con-ceptual framework was tested on a random sample of gas consumers residing in the area of Thessaloniki, Greece. The final sample consisted of 437 adult consumers. The reliability and the validity of the questionnaire were thoroughly examined. Empirical data were analysed using the “Structural Equation Modelling” (SEM technique. The present study is empirical, explanatory, deductive and, mainly, quantitative. Findings – Empirical results indicate that "reliability" has the highest impact on "customer satisfaction", while "empathy" has no impact at all. More specifically, the impact of "reliability" on "customer satisfaction" is indirect, mediated through three other di-mensions of the conceptual framework (namely, "tangibles", "responsiveness" and "empathy". Research limitations/implications – A limitation stemming from the implemented methodology is the use of self-reported scales for the measurement of the six research factors. Moreover, the paper lacks a longitudinal approach. Finally, the empirical research (survey is focused on one organisation and, therefore, offers relatively limited generalizability. Originality/value – Very few studies have utilised the SERVQUAL approach in the context of an explanatory research. This approach

  13. The conceptualization and empirical validation of website user satisfaction

    NARCIS (Netherlands)

    Moenaert, R.K.; Muylle, S.; Despontin, M.

    2004-01-01

    This article addresses the concern for effective web site design by means of the conceptualization and empirical validation of a web site user satisfaction construct. Based on IS success theory, hypermedia design theory, a qualitative exploratory pilot study, and a quantitative online critical

  14. The Socratic Method: Empirical Assessment of a Psychology Capstone Course

    Science.gov (United States)

    Burns, Lawrence R.; Stephenson, Paul L.; Bellamy, Katy

    2016-01-01

    Although students make some epistemological progress during college, most graduate without developing meaning-making strategies that reflect an understanding that knowledge is socially constructed. Using a pre-test-post-test design and a within-subjects 2 × 2 mixed-design ANOVA, this study reports on empirical findings which support the Socratic…

  15. DESIGN AND IMPLEMENTATION OF A CO2 FLOOD UTILIZING ADVANCED RESERVOIR CHARACTERIZATION AND HORIZONTAL INJECTION WELLS IN A SHALLOW SHELF CARBONATE APPROACHING WATERFLOOD DEPLETION

    Energy Technology Data Exchange (ETDEWEB)

    K.J. Harpole; Ed G. Durrett; Susan Snow; J.S. Bles; Carlon Robertson; C.D. Caldwell; D.J. Harms; R.L. King; B.A. Baldwin; D. Wegener; M. Navarrette

    2002-09-01

    The purpose of this project was to economically design an optimum carbon dioxide (CO{sub 2}) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO{sub 2} horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields. The Unit was a mature waterflood with water cut exceeding 95%. Oil must be mobilized through the use of a miscible or near-miscible fluid to recover significant additional reserves. Also, because the unit was relatively small, it did not have the benefit of economies of scale inherent in normal larger scale projects. Thus, new and innovative methods were required to reduce investment and operating costs. Two primary methods used to accomplish improved economics were use of reservoir characterization to restrict the flood to the higher quality rock in the unit and use of horizontal injection wells to cut investment and operating costs. The project consisted of two budget phases. Budget Phase I started in June 1994 and ended late June 1996. In this phase Reservoir Analysis, Characterization Tasks and Advanced Technology Definition Tasks were completed. Completion enabled the project to be designed, evaluated, and an Authority for Expenditure (AFE) for project implementation submitted to working interest owners for approval. Budget Phase II consisted of the implementation and execution of the project in the field. Phase II was completed in July 2001. Performance monitoring, during Phase II, by mid 1998 identified the majority of producing wells which under performed their anticipated withdrawal rates. Newly drilled and re-activated wells had lower offtake rates than originally forecasted. As a result of poor offtake, higher reservoir pressure was a concern

  16. Investigation of storage system designs and techniques for optimizing energy conservation in integrated utility systems. Volume 2: (Application of energy storage to IUS)

    Science.gov (United States)

    1976-01-01

    The applicability of energy storage devices to any energy system depends on the performance and cost characteristics of the larger basic system. A comparative assessment of energy storage alternatives for application to IUS which addresses the systems aspects of the overall installation is described. Factors considered include: (1) descriptions of the two no-storage IUS baselines utilized as yardsticks for comparison throughout the study; (2) discussions of the assessment criteria and the selection framework employed; (3) a summary of the rationale utilized in selecting water storage as the primary energy storage candidate for near term application to IUS; (4) discussion of the integration aspects of water storage systems; and (5) an assessment of IUS with water storage in alternative climates.

  17. Utilizing 3D-visualization to apply compulsory ALARA principles in nuclear power plant design and day-to-day operation

    International Nuclear Information System (INIS)

    Sanders, R. L.; Lake, J. E.

    2006-01-01

    The development of an advanced visualization and simulation tool to support both design as well as day-to-day operation is presented. This tool exploits cutting edge computer graphics, physics-based effects modeling, virtual reality, and gaming technologies to establish a system that can eventually be used for the administrative planning and training of plant operators and design engineers. (authors)

  18. A New Empirical Model to Estimate Landfill Gas Pollution

    Directory of Open Access Journals (Sweden)

    Hamidreza Kamalan

    2016-07-01

    Full Text Available Background: Landfills are the most important producers of methane as human source. So, prediction of landfill gas generation is by far the most important concern of scientists, decision makers, and landfill owners as well as health authorities. Almost all the currently used models are based on Monod equation first order decay rate which is experimental while the main purpose of this research is to develop a numerical model. Methods: A real scale pilot landfill with 4500 tons of municipal solid waste has been designed, constructed, and operated for two years. Required measurements have been done to provide proper data on greenhouse gases emitted by the landfill and monitor its status such as internal temperature, leachate content, and its settlement during two years. Afterwards, weighted residual method has been used to develop the numerical model. Then, the newly mathematical method has been verified with data from another landfill. Results: Measurements showed that the minimum and maximum percentages of methane among landfill gas were 22.3 and 46.1%, respectively. These values for velocity of landfill gas are 0.3 and 0.48 meters per second, in that order. Conclusion: Since there is just 0.6 percent error in calculation as compared to real measurements from a landfill in California and most of the models used have ten percent error, this simple empirical numerical model is suggested to be utilized by scientists, decision makers, and landfill owners

  19. Empirical Reduced-Order Modeling for Boundary Feedback Flow Control

    Directory of Open Access Journals (Sweden)

    Seddik M. Djouadi

    2008-01-01

    Full Text Available This paper deals with the practical and theoretical implications of model reduction for aerodynamic flow-based control problems. Various aspects of model reduction are discussed that apply to partial differential equation- (PDE- based models in general. Specifically, the proper orthogonal decomposition (POD of a high dimension system as well as frequency domain identification methods are discussed for initial model construction. Projections on the POD basis give a nonlinear Galerkin model. Then, a model reduction method based on empirical balanced truncation is developed and applied to the Galerkin model. The rationale for doing so is that linear subspace approximations to exact submanifolds associated with nonlinear controllability and observability require only standard matrix manipulations utilizing simulation/experimental data. The proposed method uses a chirp signal as input to produce the output in the eigensystem realization algorithm (ERA. This method estimates the system's Markov parameters that accurately reproduce the output. Balanced truncation is used to show that model reduction is still effective on ERA produced approximated systems. The method is applied to a prototype convective flow on obstacle geometry. An H∞ feedback flow controller is designed based on the reduced model to achieve tracking and then applied to the full-order model with excellent performance.

  20. Umayyad Relations with Byzantium Empire

    Directory of Open Access Journals (Sweden)

    Mansoor Haidari

    2017-06-01

    Full Text Available This research investigates the political and military relations between Umayyad caliphates with the Byzantine Empire. The aim of this research is to clarify Umayyad caliphate’s relations with the Byzantine Empire. We know that these relations were mostly about war and fight. Because there were always intense conflicts between Muslims and the Byzantine Empire, they had to have an active continuous diplomacy to call truce and settle the disputes. Thus, based on the general policy of the Umayyad caliphs, Christians were severely ignored and segregated within Islamic territories. This segregation of the Christians was highly affected by political relationships. It is worthy of mentioning that Umayyad caliphs brought the governing style of the Sassanid kings and Roman Caesar into the Islamic Caliphate system but they didn’t establish civil institutions and administrative organizations.

  1. Process Design Report for Wood Feedstock: Lignocellulosic Biomass to Ethanol Process Desing and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Wooley, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sheehan, John [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ibsen, Kelly [National Renewable Energy Lab. (NREL), Golden, CO (United States); Majdeski, Henry [Delta-T Corporation, Lexington, KY (United States); Galves, Adrian [Delta-T Corporation, Lexington, KY (United States)

    1999-07-01

    The National Renewable Energy Laboratory (NREL) has undertaken a complete review and update of the process design and economic model for the biomass-to-ethanol process based on co-current dilute acid prehydrolysis, along with simultaneous saccharification (enzymatic) and co-fermentation. The process design includes the core technologies being researched by the U.S. Department of Energy (DOE): prehydrolysis, simultaneous saccharification and co-fermentation, and cellulase enzyme production.

  2. An Instagram is worth a thousand words. : The utilization of Instagram as a key social media marketing strategy. Case: Valona Design.

    OpenAIRE

    Tran, My

    2016-01-01

    This bachelor thesis presents a project, which is commissioned by Valona Design, a Finnish-based design company in arts and crafts. The main outcome of this thesis is to familiarize the reader with the fast-changing social media branding, which is applied to the commissioning company. The final objective of this thesis is to produce a customized content marketing calendar for the commissioning company which is based on the social media branding’s framework. The content marketing calendar...

  3. A technology data base for the design of 500 to 5000-lb thrust class liquid rocket engines utilizing hydrogen and oxygen as propellants

    Science.gov (United States)

    Schoenman, L.

    1982-01-01

    This paper presents an overview of the results of experimental evaluations of candidate designs for igniters, injectors, and propellant-cooled thrust chambers applicable to restartable high-performance, high-reliability upper-stage engines and to pulsing-type reaction control engines (RCE). Injection element types best suited for liquid, gas, and liquid/gas phase propellant supply are identified. The resulting interactions between element type, combustion efficiency, and chamber wall heating are compared. The distinction between thrust chamber design requirements for upper stage vs RCE applications as measured by cycle life requirements is translated into design configurations consisting of all-film-cooled, all-regeneratively-cooled, and composites of the two cooling approaches. The validity of the design approaches is confirmed by data from engine durability testing involving over 90,000 starts and 9,000 thermal cycles on RCE-type designs and multiple long-duration burns (up to 2,000 sec) on regeneratively cooled upper-stage designs.

  4. Casual Empire: Video Games as Neocolonial Praxis

    Directory of Open Access Journals (Sweden)

    Sabine Harrer

    2018-01-01

    Full Text Available As a media form entwined in the U.S. military-industrial complex, video games continue to celebrate imperialist imagery and Western-centric narratives of the great white explorer (Breger, 2008; Dyer-Witheford & de Peuter, 2009; Geyser & Tshalabala, 2011; Mukherjee, 2016. While much ink has been spilt on the detrimental effects of colonial imagery on those it objectifies and dehumanises, the question is why these games still get made, and what mechanisms are at work in the enjoyment of empire-themed play experiences. To explore this question, this article develops the concept of ‘casual empire’, suggesting that the wish to play games as a casual pastime expedites the incidental circulation of imperialist ideology. Three examples – 'Resident Evil V' (2009, 'The Conquest: Colonization' (2015 and 'Playing History: Slave Trade' (2013 – are used to demonstrate the production and consumption of casual empire across multiple platforms, genres and player bases. Following a brief contextualisation of postcolonial (game studies, this article addresses casual design, by which I understand game designers’ casual reproduction of inferential racism (Hall, 1995 for the sake of entertainment. I then look at casual play, and players’ attitudes to games as rational commodities continuing a history of commodity racism (McClintock, 1995. Finally, the article investigates the casual involvement of formalist game studies in the construction of imperial values. These three dimensions of the casual – design, play and academia – make up the three pillars of the casual empire that must be challenged to undermine video games’ neocolonialist praxis.

  5. Low-Btu coal-gasification-process design report for Combustion Engineering/Gulf States Utilities coal-gasification demonstration plant. [Natural gas or No. 2 fuel oil to natural gas or No. 2 fuel oil or low Btu gas

    Energy Technology Data Exchange (ETDEWEB)

    Andrus, H E; Rebula, E; Thibeault, P R; Koucky, R W

    1982-06-01

    This report describes a coal gasification demonstration plant that was designed to retrofit an existing steam boiler. The design uses Combustion Engineering's air blown, atmospheric pressure, entrained flow coal gasification process to produce low-Btu gas and steam for Gulf States Utilities Nelson No. 3 boiler which is rated at a nominal 150 MW of electrical power. Following the retrofit, the boiler, originally designed to fire natural gas or No. 2 oil, will be able to achieve full load power output on natural gas, No. 2 oil, or low-Btu gas. The gasifier and the boiler are integrated, in that the steam generated in the gasifier is combined with steam from the boiler to produce full load. The original contract called for a complete process and mechanical design of the gasification plant. However, the contract was curtailed after the process design was completed, but before the mechanical design was started. Based on the well defined process, but limited mechanical design, a preliminary cost estimate for the installation was completed.

  6. FY 1999 Technical research and development for environmentally friendly and highly efficient energy utilization system. Technical research and development for highly efficient and effective energy utilization (Technical research and development for optimum system designs - Part 3); 1999 nendo kankyo chowagata kokoritsu energy riyo system kaihatsu seika hokokusho. 3. Kokoritsu energy yuko riyo gijutsu no kenkyu (saiteki system sekkei gijutsu no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    Research and development program is conducted for the elementary techniques as part of the eco-energy urban project of New Sunshine Project. Described herein are the FY 1999 results for the (techniques for transportation and storage of energy (continued), energy supply and utilization, reducing environmental loads, and designing the optimum systems). The R and D on heat transfer system through the vacuum heat insulation pipes involves fabrication, on a trial basis, the vacuum insulation covers for the vacuum insulation tubes, joints, flanges and valves for the 80A pipes, and the heat loss evaluation test for each item. The R and D on the energy supply and utilization techniques involves the heat transfer systems for a variety of fuels by the highly functional heat pump, and compression/absorption hybrid type heat-utilization system. The hybrid type heat-utilization system simulation results suggest possibility of achieving exergy efficiency of 56% as the development target by use of the new medium. The R and D on the environmental load reduction involves the power-saving type heat pump systems which use a natural coolant. (NEDO)

  7. FY 2000 report on the results of the development of the environmentally friendly type high efficiency energy utilization system. Part 2. Study of the effective utilization technology of high efficiency energy (Study of the optimum system design technology); 2000 nendo kankyo chowagata kokoritsu energy riyo system kaihatsu seika hokokusho. 2. Kokoritsu energy yuko riyo gijutsu no kenkyu (saiteki system sekkei gijutsu no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-05-01

    The paper conducted the development of the environmentally friendly type high efficiency energy utilization system and the R and D of the high efficiency energy effective utilization technology, and the FY 2000 results were summed up. As to the energy transportation/storage technology, the R and D were made on the following: methanol/energy system, non-equilibrium high efficiency methanol decomposition reaction technology, development of multiple functions of catalyst, high efficiency heat pump technology using hydrogen storage alloys, heat-hydrogen recovery/transportation/utilization technology, vacuum insulated heat transport piping system, surfactant used for high density heat transport, high density latent heat transportation technology, etc. Concerning the energy supply/utilization technology, the R and D were made of the heat supply system using high efficient heat pump corresponding to multiple fuels. Relating to the environmental load reduction technology, the energy conserved heat pump system using natural coolant. As to the optimum system design technology, the comprehensive preparation of element technology, etc. (NEDO)

  8. Advanced conceptual design of the solar-repowering system for West Texas Utilities Company, Paint Creek Power Station Unit No. 4. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1982-05-07

    The results of the conceptual design study reported include the development of a workable design for a sodium-cooled tower focus repowering system, the costs required to construct that design, and the determination of the benefits which could be obtained. A number of trade studies and optimizations were carried out in order to derive the most cost-effective design that also had the greatest potential for widespread application and commercialization. These studies are identified and their results are presented and discussed. The overall plant design is described and diagrammed, as are each of the subsystems: the heliostats, external receiver, master control, heat transport, thermal storage, electric power generating, and steam generating subsystems. Each subsystem's cost is summarized by major component. The subsystem is then described with its major components in terms of physical characteristics, requirements, and performance. An economic analysis is presented based on the internal rate of return to the project owner, and development plans are described. Appended is the system requirements specification. The testing and results for a sodium-cooled receiver panel are described. (LEW)

  9. Empirical estimates of the NAIRU

    DEFF Research Database (Denmark)

    Madsen, Jakob Brøchner

    2005-01-01

    Empirical studies have found that the non-accelerating inflation rate of unemployment (NAIRU) has been fluctuating in OECD countries around a constant mean of several percentage points over the past decades. This mean is calculated from the constant terms carried over from the wage and price growth...

  10. Gazprom the new russian empire

    International Nuclear Information System (INIS)

    Cosnard, D.

    2004-01-01

    The author analyzes the economical and political impacts of the great Gazprom group, leader in the russian energy domain, in Russia. Already number one of the world gas industry, this Group is becoming the right-hand of the Kremlin. Thus the author wonders on this empire transparency and limits. (A.L.B.)

  11. Empire as a Geopolitical Figure

    DEFF Research Database (Denmark)

    Parker, Noel

    2010-01-01

    after all that has happened in the late twentieth century to undermine nationalism and the national state. Empire is indeed a probable, even for some an attractive form of regime for extending order over the disorder produced by globalisation. Geopolitics articulated in imperial expansion is likely...

  12. Symmetry, empirical significance, and identity

    NARCIS (Netherlands)

    Friederich, Simon

    The article proposes a novel approach to the much discussed question of which symmetries have ‘direct empirical significance’ and which do not. The approach is based on a development of a recently proposed framework by Hilary Greaves and David Wallace, who claim that, contrary to the standard

  13. Empirical Productivity Indices and Indicators

    NARCIS (Netherlands)

    B.M. Balk (Bert)

    2016-01-01

    textabstractThe empirical measurement of productivity change (or difference) by means of indices and indicators starts with the ex post profit/loss accounts of a production unit. Key concepts are profit, leading to indicators, and profitability, leading to indices. The main task for the productivity

  14. Phenomenology and the Empirical Turn

    NARCIS (Netherlands)

    Zwier, Jochem; Blok, Vincent; Lemmens, Pieter

    2016-01-01

    This paper provides a phenomenological analysis of postphenomenological philosophy of technology. While acknowledging that the results of its analyses are to be recognized as original, insightful, and valuable, we will argue that in its execution of the empirical turn, postphenomenology forfeits

  15. Empirical laws, regularity and necessity

    NARCIS (Netherlands)

    Koningsveld, H.

    1973-01-01

    In this book I have tried to develop an analysis of the concept of an empirical law, an analysis that differs in many ways from the alternative analyse's found in contemporary literature dealing with the subject.

    1 am referring especially to two well-known views, viz. the regularity and

  16. Empirical analysis of consumer behavior

    NARCIS (Netherlands)

    Huang, Yufeng

    2015-01-01

    This thesis consists of three essays in quantitative marketing, focusing on structural empirical analysis of consumer behavior. In the first essay, he investigates the role of a consumer's skill of product usage, and its imperfect transferability across brands, in her product choice. It shows that

  17. Power-scavenging Tumbleweed Rover Design, development, and testing of a Tumbleweed rover capable of generating electrical power by utilizing wind energy

    Science.gov (United States)

    Basic, Goran Jurisa

    Most current space robotics vehicles use solar energy as their prime energy source. In spherical robotic vehicles the use of solar cells is very restricted. Focusing on the particular problem, an improved method to generate electrical power will be developed; the innovation is the use of an internal pendulum-generator mechanism to generate electrical power while the ball is rolling. This concept will enable spherical robots on future long-duration planetary exploration missions. Through a developed proof-of-concept prototype, inspired by the Russian thistle plant, or tumbleweed, this thesis will demonstrate power generation capabilities of such a mechanism. Furthermore, it will also present and validate a parametric analytical model that can be used in future developments as a design tool to quantify power and define design parameters. The same model was used to define the design parameters and power generation capabilities of such a system in Martian environment.

  18. Development of a premium Quality Plasma derived IVIg (IQYMUNE®) utilizing the principles of Quality by Design - A worked through case study.

    Science.gov (United States)

    Paolantonacci, Philippe; Appourchaux, Philippe; Claudel, Béatrice; Ollivier, Monique; Dennett, Richard; Siret, Laurent

    2017-11-20

    Polyvalent human normal immunoglobulins for intravenous use (IVIG), indicated for rare and often severe diseases, are complex plasma-derived protein preparations. A Quality by Design (QbD) approach has been used to develop the LFB new generation IVIG, targeting a high level of purity to generate an enhanced safety profile while maintaining a high level of efficacy. A modular approach of QbD was implemented consisting of five consecutive steps to cover all the stages from the product design to the final product control strategy. A well-defined target product profile was translated into 27 Product Quality Attributes (PQAs) that formed the basis of the process design. In parallel, a product risk analysis was conducted and identified 19 Critical Quality Attributes (CQAs) among PQAs. Process risk analysis was carried out to establish the links between process parameters and CQAs. Twelve critical steps were identified and for each of these steps a risk mitigation plan was established. Among the different process risk mitigation exercises, five process robustness studies were conducted at qualified small scale with a Design of Experiment (DoE) approach. For each process step, critical process parameters (CPPs) were identified and, for each CPP, Proven Acceptable Ranges (PARs) were established. The quality risk management (QRM) and risk mitigation outputs, including verification of PARs, were used to design the process verification exercise at industrial scale. Finally, the Control Strategy was established using a mix, or 'hybrid', of the 'traditional approach', plus elements of the QbD 'enhanced approach' as illustrated, to more robustly assign material and process controls, and in order to securely meet product specifications The advantages of this QbD approach were improved process knowledge for industrial design and process validation and a clear justification of the process and product specifications as a basis for control strategy and future comparability exercises

  19. Advanced Utility Simulation Model: multi-period multi-state module design documentation (Version 1. 0). Final report, October 1982-November 1984

    Energy Technology Data Exchange (ETDEWEB)

    Edahl, R.; Tyle, N.; Talukdar, S.N.; Pachavis, N.L.

    1988-04-01

    This report is one of 11 in a series describing the initial development of the Advanced Utility Simulation Model (AUSM) by the Universities Research Group on Energy (URGE) and its continued development by the Science Applications International Corporation (SAIC) research team. The AUSM is one of four stationary-source emission and control cost-forecasting models developed by EPA for the National Acid Precipitation Assessment Program (NAPAP). The AUSM projects air pollution emissions (SO/sub 2/ and NOx), generating technology types and costs of operation, and combinations of fuels and emission-control technologies to simultaneously meet electric demand and emission constraints on a least-cost basis for each year through 2010. Thirteen electric-demand regions are simulated, and output is provided for each of the 48 states.

  20. The utility of 3D printing for surgical planning and patient-specific implant design for complex spinal pathologies: case report.

    Science.gov (United States)

    Mobbs, Ralph J; Coughlan, Marc; Thompson, Robert; Sutterlin, Chester E; Phan, Kevin

    2017-04-01

    OBJECTIVE There has been a recent renewed interest in the use and potential applications of 3D printing in the assistance of surgical planning and the development of personalized prostheses. There have been few reports on the use of 3D printing for implants designed to be used in complex spinal surgery. METHODS The authors report 2 cases in which 3D printing was used for surgical planning as a preoperative mold, and for a custom-designed titanium prosthesis: one patient with a C-1/C-2 chordoma who underwent tumor resection and vertebral reconstruction, and another patient with a custom-designed titanium anterior fusion cage for an unusual congenital spinal deformity. RESULTS In both presented cases, the custom-designed and custom-built implants were easily slotted into position, which facilitated the surgery and shortened the procedure time, avoiding further complex reconstruction such as harvesting rib or fibular grafts and fashioning these grafts intraoperatively to fit the defect. Radiological follow-up for both cases demonstrated successful fusion at 9 and 12 months, respectively. CONCLUSIONS These cases demonstrate the feasibility of the use of 3D modeling and printing to develop personalized prostheses and can ease the difficulty of complex spinal surgery. Possible future directions of research include the combination of 3D-printed implants and biologics, as well as the development of bioceramic composites and custom implants for load-bearing purposes.

  1. The Modification of Educational Equipment and Curriculum for Maximum Utilization by Physically Disabled Persons; Design of a School for Physically Disabled Students.

    Science.gov (United States)

    Yuker, Harold E.; And Others

    Elements of modified school design for the physically disabled are considered, including mobility, classrooms, science laboratories, applied skill areas, the library, the swimming pool, and sanitary facilities. Also discussed are the cafeteria (food service, seating, and other considerations), recreational areas (play grounds,…

  2. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  3. Guidelines for using empirical studies in software engineering education

    Directory of Open Access Journals (Sweden)

    Fabian Fagerholm

    2017-09-01

    Full Text Available Software engineering education is under constant pressure to provide students with industry-relevant knowledge and skills. Educators must address issues beyond exercises and theories that can be directly rehearsed in small settings. Industry training has similar requirements of relevance as companies seek to keep their workforce up to date with technological advances. Real-life software development often deals with large, software-intensive systems and is influenced by the complex effects of teamwork and distributed software development, which are hard to demonstrate in an educational environment. A way to experience such effects and to increase the relevance of software engineering education is to apply empirical studies in teaching. In this paper, we show how different types of empirical studies can be used for educational purposes in software engineering. We give examples illustrating how to utilize empirical studies, discuss challenges, and derive an initial guideline that supports teachers to include empirical studies in software engineering courses. Furthermore, we give examples that show how empirical studies contribute to high-quality learning outcomes, to student motivation, and to the awareness of the advantages of applying software engineering principles. Having awareness, experience, and understanding of the actions required, students are more likely to apply such principles under real-life constraints in their working life.

  4. Proposed empirical gas geothermometer using multidimensional approach

    Energy Technology Data Exchange (ETDEWEB)

    Supranto; Sudjatmiko; Toha, Budianto; Wintolo, Djoko; Alhamid, Idrus

    1996-01-24

    Several formulas of surface gas geothermometer have been developed to utilize in geothermal exploration, i.e. by D'Amore and Panichi (1980) and by Darling and Talbot (1992). This paper presents an empirical gas geothermometer formula using multidimensional approach. The formula was derived from 37 selected chemical data of the 5 production wells from the Awibengkok Geothermal Volcanic Field in West Java. Seven components, i.e., gas volume percentage, CO2, H2S, CH4, H2, N2, and NH3, from these data are utilize to developed three model equations which represent relationship between temperature and gas compositions. These formulas are then tested by several fumarolic chemical data from Sibual-buali Area (North Sumatera) and from Ringgit Area (South Sumatera). Preliminary result indicated that gas volume percentage, H2S and CO2 concentrations have a significant role in term of gas geothermometer. Further verification is currently in progress.

  5. Utilization of Monte Carlo Calculations in Radiation Transport Analyses to Support the Design of the U.S. Spallation Neutron Source (SNS)

    International Nuclear Information System (INIS)

    Johnson, J.O.

    2000-01-01

    The Department of Energy (DOE) has given the Spallation Neutron Source (SNS) project approval to begin Title I design of the proposed facility to be built at Oak Ridge National Laboratory (ORNL) and construction is scheduled to commence in FY01 . The SNS initially will consist of an accelerator system capable of delivering an ∼0.5 microsecond pulse of 1 GeV protons, at a 60 Hz frequency, with 1 MW of beam power, into a single target station. The SNS will eventually be upgraded to a 2 MW facility with two target stations (a 60 Hz station and a 10 Hz station). The radiation transport analysis, which includes the neutronic, shielding, activation, and safety analyses, is critical to the design of an intense high-energy accelerator facility like the proposed SNS, and the Monte Carlo method is the cornerstone of the radiation transport analyses

  6. Design and Implementation of a CO2 Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells In a Shallow Shelf Carbonate Approaching Waterflood Depletion

    Energy Technology Data Exchange (ETDEWEB)

    Czirr, K.L.; Owen, R.; Robertson, C.R.; Harpole, K.J.; Durrett, E.G.

    1999-11-09

    This project consist of two budget phases. Budget Phase I started in June 1994 and ended late June 1996. During this phase the Reservoir Analysis and Characterization Task and the Advanced Technology Definition Task were completed. Completion of these tasks enabled the project to be designed, and an Authority for Expenditure (AFE) for project implementation to be generated and submitted to the working interest owners for approval. Budget Phase II consists of the implementation and execution of the project in the field.

  7. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios

    Science.gov (United States)

    1999-07-01

    small amount of waste biomass ( sludge ). Burning these by- product streams to generate steam and electricity for the process reduces solid waste disposal...streams (centrifuge solids, biogas and evaporator syrup) are fed to a Circulating Fluidized Bed Combustor (CFBC). The small amount of waste biomass ( sludge ...various combinations of combustor designs and feeds being used. Because of heightened interest in using biomass, pulping wastes, and sewage sludge in

  8. Broader utilization of programmable automation equipment in French nuclear power plants: Reflections on the choices made by Electricite de France and French designers

    International Nuclear Information System (INIS)

    Baudry, Y.; Varaldi, G.

    1983-01-01

    More than 1000 microprocessors and more than 10,000 data memories in each of the twenty or so 1300 MW units in the French nuclear programme: that was the decision taken by Electricite de France (EDF) in conjunction with the designers in 1974, with the intention of introducing programmable automata on a wide scale in French nuclear power plants. This programme was carried out with the assistance of advanced research services such as the universities, the Commissariat a l'energie atomique (CEA), EDF's design and research service and the designers, most of whom were already EDF suppliers for the 900 MW range. Having used computers for linking sequences (themselves carried out with electromagnetic technology) for its latest natural-uranium gas-cooled graphite-moderated power plants, EDF decided to call a temporary halt, in the case of its 900 MW light-water range, to the use of digital techniques for the control and automation of power plants although it continued to employ such techniques widely in data processing. Thus, the widespread introduction of programmable automata, which was decided upon in 1974/75 at a time when no equivalent existed at the international level, led EDF and French designers to undertake a major development effort in order to meet the requirements - particularly safety and reliability requirements - for such automata to be incorporated into the nuclear field. How does this choice fit in with the logical evolution of the digitalization of French nuclear power plants. What problems has it caused for EDF and French industry. How have these problems been tackled. How have they been overcome. These are the questions dealt with in this paper. (author)

  9. Towards Multi-Method Research Approach in Empirical Software Engineering

    Science.gov (United States)

    Mandić, Vladimir; Markkula, Jouni; Oivo, Markku

    This paper presents results of a literature analysis on Empirical Research Approaches in Software Engineering (SE). The analysis explores reasons why traditional methods, such as statistical hypothesis testing and experiment replication are weakly utilized in the field of SE. It appears that basic assumptions and preconditions of the traditional methods are contradicting the actual situation in the SE. Furthermore, we have identified main issues that should be considered by the researcher when selecting the research approach. In virtue of reasons for weak utilization of traditional methods we propose stronger use of Multi-Method approach with Pragmatism as the philosophical standpoint.

  10. Distance learning strategies for weight management utilizing social media: A comparison of phone conference call versus social media platform. Rationale and design for a randomized study.

    Science.gov (United States)

    Willis, Erik A; Szabo-Reed, Amanda N; Ptomey, Lauren T; Steger, Felicia L; Honas, Jeffery J; Al-Hihi, Eyad M; Lee, Robert; Vansaghi, Lisa; Washburn, Richard A; Donnelly, Joseph E

    2016-03-01

    Management of obesity in the context of the primary care physician visit is of limited efficacy in part because of limited ability to engage participants in sustained behavior change between physician visits. Therefore, healthcare systems must find methods to address obesity that reach beyond the walls of clinics and hospitals and address the issues of lifestyle modification in a cost-conscious way. The dramatic increase in technology and online social networks may present healthcare providers with innovative ways to deliver weight management programs that could have an impact on health care at the population level. A randomized study will be conducted on 70 obese adults (BMI 30.0-45.0 kg/m(2)) to determine if weight loss (6 months) is equivalent between weight management interventions utilizing behavioral strategies by either a conference call or social media approach. The primary outcome, body weight, will be assessed at baseline and 6 months. Secondary outcomes including waist circumference, energy and macronutrient intake, and physical activity will be assessed on the same schedule. In addition, a cost analysis and process evaluation will be completed. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Empirical determinants of relationship lending

    Directory of Open Access Journals (Sweden)

    Sahar Loukil

    2016-12-01

    Full Text Available We study the determinants of the incidence of relationship lending. For our study, we combine established insights from the study of Elsas with empirical banking relationship lending literature. We relate loan contract and borrower characteristics to self-assessments of Tunisian banks with respect to the existence of close relationship. Using detailed loan contract information from Tunisian banks and a questionnaire addressed to loan officers, we report the first comprehensive evidence on the development of relationship lending. We find that access to information, the ability to influence the manager, and the solvency of the company are relevant factors. While the exclusivity and the duration of the relationship, classic measures of the existence of close ties with the bank, are not determining factors. So these proxy measures should be used with caution in future empirical works.

  12. The Myth of Global Empire

    Directory of Open Access Journals (Sweden)

    Fernando Mires

    2009-12-01

    Full Text Available This essay openly questions the new phantom that is going all around the world, called the Marxism-Globalism. The critiques are exposed through the reading of one of the most discussed book in these last years: Empire, written by Richard Hardt y Toni Negri. According to the author of current essay, the difference between Marxism-Leninism and the Marxism-Globalism, is that the first of them brought with it the promise of total security (no properties, no State, no social classes, and the second one brought the dammed promise of total globality (Capitalism Empire, in which we find, in the right hand, the world market spirit, and, in the left hand, the globalities of postmodernism.

  13. Empirical distribution function under heteroscedasticity

    Czech Academy of Sciences Publication Activity Database

    Víšek, Jan Ámos

    2011-01-01

    Roč. 45, č. 5 (2011), s. 497-508 ISSN 0233-1888 Grant - others:GA UK(CZ) GA402/09/0557 Institutional research plan: CEZ:AV0Z10750506 Keywords : Robustness * Convergence * Empirical distribution * Heteroscedasticity Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.724, year: 2011 http://library.utia.cas.cz/separaty/2011/SI/visek-0365534.pdf

  14. Corruption and Education: Empirical Evidence

    OpenAIRE

    Mohamed Dridi

    2014-01-01

    Corruption is widely believed to be detrimental to economic performance. However, little empirical evidence has been presented to assess its consequences on education.Using various education indicators, this paper aims to examine the effects of corruption on education both from a quantitative and qualitative point of view. The cross - country regression analysis shows a strong link between corruption and secondary school enrollment rates, but the relationship between corruption and education ...

  15. Empirical analysis of consumer behavior

    OpenAIRE

    Huang, Yufeng

    2015-01-01

    This thesis consists of three essays in quantitative marketing, focusing on structural empirical analysis of consumer behavior. In the first essay, he investigates the role of a consumer's skill of product usage, and its imperfect transferability across brands, in her product choice. It shows that experienced consumers have higher but more specialized demand towards high-end products. The second essay investigates a consumer’s choice of considering a product before purchase. Because considera...

  16. Empirical research on Waldorf education

    OpenAIRE

    Randoll, Dirk; Peters, Jürgen

    2015-01-01

    Waldorf education began in 1919 with the first Waldorf School in Stuttgart and nowadays is widespread in many countries all over the world. Empirical research, however, has been rare until the early nineties and Waldorf education has not been discussed within educational science so far. This has changed during the last decades. This article reviews the results of surveys during the last 20 years and is mainly focused on German Waldorf Schools, because most investigations have been done in thi...

  17. Design and implementing a diffuse controller that, intervenes the electronic injection of fuel in a vehicle, for the utilization HHO as a supplementary fuel

    International Nuclear Information System (INIS)

    Chinchilla Vargas, Erick Gustavo

    2014-01-01

    A study was performed on the behavior of an internal combustion engine of a vehicle when has added oxyhydrogen (HHO) as a supplementary fuel, produced from a modified alkaline type electrolyser called HHO generator. The first stage is consisted of a theoretical and experimental analysis of the happened in the internal combustion engine by adding oxyhydrogen. The experimental part has performed road tests and equipment available were used in the engine test laboratories of RECOPE, as a roller dynamometer and a gas analyzer. The result from this first stage has found a slight increase in fuel performance and an unstable idling speed in the engine, this latest product in the vehicle's computer has been without design for the engine had operate with the addition of HHO. The second stage has designed one controller based in the diffuse logic with it is achieved in fuel performance and the flaws found are annulled. The third stage has involved the implementation of controller in the vehicle, which has involved taking the sensor signals of airflow and oxygen, pass by the controller, to be assigned new parameters and then deliver again to the vehicle computer without this notice the change. The performance of the designed controller is verified in the fourth stage, the same tests were made as in the first stage, in this way it was possible to verify and validate the data. Finally, a further increase is obtained in vehicle fuel efficiency, coupled with improved engine performance in different driving conditions without sacrificing power and torque. (author) [es

  18. The empirical war on drugs.

    Science.gov (United States)

    Vitellone, Nicole

    2013-05-01

    In a special issue of the journal Addictions (1995) academics, researchers and health care professionals debated the status of the empirical in socially orientated drugs research. A number of researchers noted that our knowledge and understanding of drugs and drug users has changed significantly since the 1990s. Post AIDS this shift is identified as a consequence of the development of qualitative research methods. The qualitative turn in drugs research has involved a shift away form traditional epidemiological approaches and the pursuit of more socially focused methods. Whilst qualitative research has yielded important empirical data on risk behavior the pursuit of these methods has not been without controversy. In addressing the debate on methods in the drugs field this article investigates the effects of social science methods for research on injecting drug use. In so doing I examine what counts and what gets left out of research on injecting beaviour. Drawing on Actor Network Theory (ANT) I suggest Bruno Latour's methodological approach offers critical insights for addressing the empirical objects of injecting drug use. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Two concepts of empirical ethics.

    Science.gov (United States)

    Parker, Malcolm

    2009-05-01

    The turn to empirical ethics answers two calls. The first is for a richer account of morality than that afforded by bioethical principlism, which is cast as excessively abstract and thin on the facts. The second is for the facts in question to be those of human experience and not some other, unworldly realm. Empirical ethics therefore promises a richer naturalistic ethics, but in fulfilling the second call it often fails to heed the metaethical requirements related to the first. Empirical ethics risks losing the normative edge which necessarily characterizes the ethical, by failing to account for the nature and the logic of moral norms. I sketch a naturalistic theory, teleological expressivism (TE), which negotiates the naturalistic fallacy by providing a more satisfactory means of taking into account facts and research data with ethical implications. The examples of informed consent and the euthanasia debate are used to illustrate the superiority of this approach, and the problems consequent on including the facts in the wrong kind of way.

  20. A Review of Empirical Evidence on Scaffolding for Science Education

    Science.gov (United States)

    Lin, Tzu-Chiang; Hsu, Ying-Shao; Lin, Shu-Sheng; Changlai, Maio-Li; Yang, Kun-Yuan; Lai, Ting-Ling

    2012-01-01

    This content analysis of articles in the Social Science Citation Index journals from 1995 to 2009 was conducted to provide science educators with empirical evidence regarding the effects of scaffolding on science learning. It clarifies the definition, design, and implementation of scaffolding in science classrooms and research studies. The results…

  1. Empirical deck for phased construction and widening [summary].

    Science.gov (United States)

    2017-06-01

    The most common method used to design and analyze bridge decks, termed the traditional : method, treats a deck slab as if it were made of strips supported by inflexible girders. An : alternative the empirical method treats the deck slab as a ...

  2. Teaching Psychology and Law: An Empirical Evaluation of Experiential Learning

    Science.gov (United States)

    Zelechoski, Amanda D.; Riggs Romaine, Christina L.; Wolbransky, Melinda

    2017-01-01

    Given the recent proliferation of undergraduate psychology and law courses, there is an increased need to empirically evaluate effective methods of teaching psycholegal material. The current study used a between- and within-subject design across four higher education institutions (N = 291 students) to evaluate the effectiveness of incorporating…

  3. Empirical Taxonomies of Gameplay Enjoyment: Personality and Video Game Preference

    Science.gov (United States)

    Quick, John M.; Atkinson, Robert K.; Lin, Lijia

    2012-01-01

    A survey study was conducted to better understand how gameplay enjoyment relates to players' personality traits and video game preferences. This study demonstrated that the core design elements of games that lead to enjoyment can be empirically identified. Similarly, it showed that considering personality, an individual characteristic, can produce…

  4. Empirical and dynamic primary energy factors

    International Nuclear Information System (INIS)

    Wilby, Mark Richard; Rodríguez González, Ana Belén; Vinagre Díaz, Juan José

    2014-01-01

    Current legislation, standards, and scientific research in the field of energy efficiency often make use of PEFs (primary energy factors). The measures employed are usually fixed and based on theoretical calculations. However given the intrinsically variable nature of energy systems, these PEFs should rely on empirical data and evolve in time. Otherwise the obtained efficiencies may not be representative of the actual energy system. In addition, incorrect PEFs may cause a negative effect on the energy efficiency measures. For instance, imposing a high value on the PEF of electricity may discourage the use of renewable energy sources, which have an actual value close to 1. In order to provide a solution to this issue, we propose an application of the Energy Networks (ENs), described in a previous work, to calculate dynamic PEFs based on empirical data. An EN represents an entire energy system both numerically and graphically, from its primary energy sources to their final energy forms, and consuming sectors. Using ENs we can calculate the PEF of any energy form and depict it in a simple and meaningful graph that shows the details of the contribution of each primary energy and the efficiency of the associated process. The analysis of these PEFs leads to significant conclusions regarding the energy models adopted among countries, their evolution in time, the selection of viable ways to improve efficiency, and the detection of best practices that could contribute to the overall energy efficiency targets. - Highlights: • Primary Energy Factors (PEFs) are foundation of much energy legislation and research. • Traditionally, they have been treated as geotemporally invariant. • This work provides a systematic and transparent methodology for adding variability. • It also shows the variability between regions due to market, policy, and technology. • Finally it demonstrates the utility of extended PEFs as a tool in their own right

  5. Interaction and educational design of mobile equipment for crisis management training

    DEFF Research Database (Denmark)

    Ørngreen, Rikke

    2011-01-01

    to this discussion, where the empirical data have to do with first aid in general and training cardiocerebral resuscitation in office settings specifically. Consequently, the paper contains design ideas, analysis and evaluation of current work with mobile equipment and augmented reality features, utilizing......As researchers and designers of crisis management training in mobile learning settings, we need to consider ways in which principles of educational design and interaction design can co-exist, in order to reach a higher quality of the analysis and design process. The paper is an input...

  6. Electromechanical systems of micro-engineering and mechatronics. Dynamical design. Fundamentals and utilization. 2. ed.; Elektromechanische Systeme der Mikrotechnik und Mechatronik. Dynamischer Entwurf. Grundlagen und Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Ballas, Ruediger G. [KARL MAYER Textilmaschinenfabrik GmbH, Obertshausen (Germany). Kompetenzbereich Piezoaktorik und Antriebstechnik; Pfeifer, Guenther [Technische Univ. Dresden (Germany). Inst. fuer Halbleiter- und Mikrosystemtechnik; Werthschuetzky, Roland [Technische Univ. Darmstadt (Germany). Inst. fuer Elektromechanische Konstruktionen

    2009-07-01

    Electromechanical systems comprising electric, mechanical and acoustic subsystems are widely used in pricision apparatus construction, sensor and actuator techniques, electroacoustics and medical technique. The textbook presents a clear engineering design method for these systems on the basis of a circuiting diagram. It provides quick access to the mechanical, acoustic, hydraulic and thermal problems by applying basic knowledge on circuiting. The second edition is a revised and didactically improved version. The network description method was extended to finite network elements and to a combination with FEA in order to combine the advantages of the two description methods and to achieve new solutions especially for higher frequencies. The book contains many new examples of how to design sensors, actuators, and direct-coupled sensor-actuator systems. There is an appendix with fundamentals of signal description and a compilation of important material data. (orig.) [German] Elektromechanische Systeme aus elektrischen, mechanischen und akustischen Teilsystemen haben im Praezisionsgeraetebau, in der Sensor- und Aktortechnik, der Elektroakustik sowie in der Medizintechnik eine grosse Bedeutung. Die Vermittlung einer anschaulichen, ingenieurmaessigen Entwurfsmethode fuer diese Systeme auf der Grundlage einer schaltungstechnischen Darstellung ist das Hauptanliegen des Lehrbuchs. Es ermoeglicht einen raschen Einstieg in die mechanischen, akustischen, hydraulischen und thermischen Problemstellungen durch die Anwendung des schaltungstechnischen Grundwissens. Die 2. Auflage wurde neu bearbeitet und didaktisch verbessert. Die Netzwerkbeschreibungsmethodik wurde auf finite Netzwerkelemente und die Kombination mit der Finite-Elemente-Beschreibung (FEM) erweitert: aus der Kombination der Vorteile beider Beschreibungsmethoden ergeben sich neuartige Loesungsansaetze vor allem im hoeheren Frequenzbereich. Das Buch bietet zahlreiche aktuelle Beispiele zum Entwurf von Sensoren und

  7. Novel method to construct large-scale design space in lubrication process utilizing Bayesian estimation based on a small-scale design-of-experiment and small sets of large-scale manufacturing data.

    Science.gov (United States)

    Maeda, Jin; Suzuki, Tatsuya; Takayama, Kozo

    2012-12-01

    A large-scale design space was constructed using a Bayesian estimation method with a small-scale design of experiments (DoE) and small sets of large-scale manufacturing data without enforcing a large-scale DoE. The small-scale DoE was conducted using various Froude numbers (X(1)) and blending times (X(2)) in the lubricant blending process for theophylline tablets. The response surfaces, design space, and their reliability of the compression rate of the powder mixture (Y(1)), tablet hardness (Y(2)), and dissolution rate (Y(3)) on a small scale were calculated using multivariate spline interpolation, a bootstrap resampling technique, and self-organizing map clustering. The constant Froude number was applied as a scale-up rule. Three experiments under an optimal condition and two experiments under other conditions were performed on a large scale. The response surfaces on the small scale were corrected to those on a large scale by Bayesian estimation using the large-scale results. Large-scale experiments under three additional sets of conditions showed that the corrected design space was more reliable than that on the small scale, even if there was some discrepancy in the pharmaceutical quality between the manufacturing scales. This approach is useful for setting up a design space in pharmaceutical development when a DoE cannot be performed at a commercial large manufacturing scale.

  8. Automation of fusion first wall design using artificial intelligence technique

    International Nuclear Information System (INIS)

    Yoshimura, Shinobu; Yagawa, Genki; Mochizuki, Yoshihiko

    1990-01-01

    This paper describes the application of artificial intelligence techniques to a design automation of the fusion first wall to be operated in the complex environment where huge electromagnetic and thermal loading as well as heavy neutron irradiation occur. As a basic strategy of designing structure shape considering many coupled phenomena, an ordinary design procedure based on the generate and test strategy is adopted because of its simplicity and broad applicability. To automate the design procedure with maintaining its flexibility, extensibility and efficiency, artificial intelligence techniques are utilized in the following. An object-oriented knowledge representation technique is adopted to store knowledge modules, that is, objects, related to the first wall design, while a data-flow processing technique is utilized as an inference mechanism among the knowledge modules. These techniques realize the flexibility and extensibility of the system. Moreover, as an efficient design modification mechanism, which is essential in a design process, an empirical approach based on experts' empirical knowledge and a mathematical approach based on a kind of numerical sensitivity analysis are introduced. The developed system is applied to a simple example of the design of a two-dimensional model of the first wall with a cooling channel, and its fundamental performance is clearly demonstrated. (author)

  9. Predição da demanda química de oxigênio em chorume maduro contendo reagente de Fenton, por meio de modelo matemático empírico gerado com planejamento fatorial completo Prediction of chemical oxygen demand in mature landfill leachate doped with Fenton's reagent, using empirical mathematical model obtained by full factorial design

    Directory of Open Access Journals (Sweden)

    André Luís de Castro Peixoto

    2008-01-01

    Full Text Available COD is an important parameter to estimate the concentration of organic contaminants. The closed system technique with the use of K2Cr2O7 is the most important one, however, it has the inconvenience to suffer positive chemical interferences from inorganic compounds such as Fe2+ and H2O2 (not enough reported in the literature. This paper considers a statistical-experimental set capable to validate a empirical mathematical model generated from a 23 experimental design, in the presence of Fe2+ and H2O2. The t test shows that mathematical model has 99,99999% confidence degree and the experimental validation test indicates absolute mean error of 4,70%.

  10. Chemistry and metallurgy in the Portuguese Empire

    Energy Technology Data Exchange (ETDEWEB)

    Habashi, F. [Laval Univ., Sainte-Foy, Quebec City, PQ (Canada)

    2000-10-01

    The foundation and expansion of the Portuguese Empire is sketched, with emphasis on the development of a new type of ship by Prince Henrique the Navigator (AD 1385-1460), known as the caravel. By virtue of its advanced design, it was capable of sailing the stormy seas at high speeds, and thereby was instrumental in extending Portuguese influence over vast territories in South America, Asia and Africa, extending Portuguese know-how in mining, metallurgy, chemistry and trade along with Christianity. The role played by the University of Coimbra, founded in 1306, and the contribution of the Brazilian Geological Survey, established in 1875, and of the School of Mines in Ouro Preto in Brazil in 1876, in the exploitation of the mineral wealth of the Portuguese colonies is chronicled.

  11. An Empirical Model for Energy Storage Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rosewater, David Martin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scott, Paul [TransPower, Poway, CA (United States)

    2016-03-17

    Improved models of energy storage systems are needed to enable the electric grid’s adaptation to increasing penetration of renewables. This paper develops a generic empirical model of energy storage system performance agnostic of type, chemistry, design or scale. Parameters for this model are calculated using test procedures adapted from the US DOE Protocol for Uniformly Measuring and Expressing the Performance of Energy Storage. We then assess the accuracy of this model for predicting the performance of the TransPower GridSaver – a 1 MW rated lithium-ion battery system that underwent laboratory experimentation and analysis. The developed model predicts a range of energy storage system performance based on the uncertainty of estimated model parameters. Finally, this model can be used to better understand the integration and coordination of energy storage on the electric grid.

  12. Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data.

    Directory of Open Access Journals (Sweden)

    Julie A McMurry

    2017-06-01

    Full Text Available In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases. Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make integration possible; identifiers are a core component of this integration infrastructure. Drawing on our experience and on work by other groups, we outline 10 lessons we have learned about the identifier qualities and best practices that facilitate large-scale data integration. Specifically, we propose actions that identifier practitioners (database providers should take in the design, provision and reuse of identifiers. We also outline the important considerations for those referencing identifiers in various circumstances, including by authors and data generators. While the importance and relevance of each lesson will vary by context, there is a need for increased awareness about how to avoid and manage common identifier problems, especially those related to persistence and web-accessibility/resolvability. We focus strongly on web-based identifiers in the life sciences; however, the principles are broadly relevant to other disciplines.

  13. Simulation model of the F/A-18 high angle-of-attack research vehicle utilized for the design of advanced control laws

    Science.gov (United States)

    Strickland, Mark E.; Bundick, W. Thomas; Messina, Michael D.; Hoffler, Keith D.; Carzoo, Susan W.; Yeager, Jessie C.; Beissner, Fred L., Jr.

    1996-01-01

    The 'f18harv' six degree-of-freedom nonlinear batch simulation used to support research in advanced control laws and flight dynamics issues as part of NASA's High Alpha Technology Program is described in this report. This simulation models an F/A-18 airplane modified to incorporate a multi-axis thrust-vectoring system for augmented pitch and yaw control power and actuated forebody strakes for enhanced aerodynamic yaw control power. The modified configuration is known as the High Alpha Research Vehicle (HARV). The 'f18harv' simulation was an outgrowth of the 'f18bas' simulation which modeled the basic F/A-18 with a preliminary version of a thrust-vectoring system designed for the HARV. The preliminary version consisted of two thrust-vectoring vanes per engine nozzle compared with the three vanes per engine actually employed on the F/A-18 HARV. The modeled flight envelope is extensive in that the aerodynamic database covers an angle-of-attack range of -10 degrees to +90 degrees, sideslip range of -20 degrees to +20 degrees, a Mach Number range between 0.0 and 2.0, and an altitude range between 0 and 60,000 feet.

  14. Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data.

    Science.gov (United States)

    McMurry, Julie A; Juty, Nick; Blomberg, Niklas; Burdett, Tony; Conlin, Tom; Conte, Nathalie; Courtot, Mélanie; Deck, John; Dumontier, Michel; Fellows, Donal K; Gonzalez-Beltran, Alejandra; Gormanns, Philipp; Grethe, Jeffrey; Hastings, Janna; Hériché, Jean-Karim; Hermjakob, Henning; Ison, Jon C; Jimenez, Rafael C; Jupp, Simon; Kunze, John; Laibe, Camille; Le Novère, Nicolas; Malone, James; Martin, Maria Jesus; McEntyre, Johanna R; Morris, Chris; Muilu, Juha; Müller, Wolfgang; Rocca-Serra, Philippe; Sansone, Susanna-Assunta; Sariyar, Murat; Snoep, Jacky L; Soiland-Reyes, Stian; Stanford, Natalie J; Swainston, Neil; Washington, Nicole; Williams, Alan R; Wimalaratne, Sarala M; Winfree, Lilly M; Wolstencroft, Katherine; Goble, Carole; Mungall, Christopher J; Haendel, Melissa A; Parkinson, Helen

    2017-06-01

    In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make integration possible; identifiers are a core component of this integration infrastructure. Drawing on our experience and on work by other groups, we outline 10 lessons we have learned about the identifier qualities and best practices that facilitate large-scale data integration. Specifically, we propose actions that identifier practitioners (database providers) should take in the design, provision and reuse of identifiers. We also outline the important considerations for those referencing identifiers in various circumstances, including by authors and data generators. While the importance and relevance of each lesson will vary by context, there is a need for increased awareness about how to avoid and manage common identifier problems, especially those related to persistence and web-accessibility/resolvability. We focus strongly on web-based identifiers in the life sciences; however, the principles are broadly relevant to other disciplines.

  15. Design of high-throughput and low-power true random number generator utilizing perpendicularly magnetized voltage-controlled magnetic tunnel junction

    Directory of Open Access Journals (Sweden)

    Hochul Lee

    2017-05-01

    Full Text Available A true random number generator based on perpendicularly magnetized voltage-controlled magnetic tunnel junction devices (MRNG is presented. Unlike MTJs used in memory applications where a stable bit is needed to store information, in this work, the MTJ is intentionally designed with small perpendicular magnetic anisotropy (PMA. This allows one to take advantage of the thermally activated fluctuations of its free layer as a stochastic noise source. Furthermore, we take advantage of the voltage dependence of anisotropy to temporarily change the MTJ state into an unstable state when a voltage is applied. Since the MTJ has two energetically stable states, the final state is randomly chosen by thermal fluctuation. The voltage controlled magnetic anisotropy (VCMA effect is used to generate the metastable state of the MTJ by lowering its energy barrier. The proposed MRNG achieves a high throughput (32 Gbps by implementing a 64×64 MTJ array into CMOS circuits and executing operations in a parallel manner. Furthermore, the circuit consumes very low energy to generate a random bit (31.5 fJ/bit due to the high energy efficiency of the voltage-controlled MTJ switching.

  16. Evidence for the Effectiveness of Jungian Psychotherapy: A Review of Empirical Studies

    Directory of Open Access Journals (Sweden)

    Christian Roesler

    2013-10-01

    Full Text Available Since the 1990s several research projects and empirical studies (process and outcome on Jungian Psychotherapy have been conducted mainly in Germany and Switzerland. Prospective, naturalistic outcome studies and retrospective studies using standardized instruments and health insurance data as well as several qualitative studies of aspects of the psychotherapeutic process will be summarized. The studies are diligently designed and the results are well applicable to the conditions of outpatient practice. All the studies show significant improvements not only on the level of symptoms and interpersonal problems, but also on the level of personality structure and in every day life conduct. These improvements remain stable after completion of therapy over a period of up to six years. Several studies show further improvements after the end of therapy, an effect which psychoanalysis has always claimed. Health insurance data show that, after Jungian therapy, patients reduce health care utilization to a level even below the average of the total population. Results of several studies show that Jungian treatment moves patients from a level of severe symptoms to a level where one can speak of psychological health. These significant changes are reached by Jungian therapy with an average of 90 sessions, which makes Jungian psychotherapy an effective and cost-effective method. Process studies support Jungian theories on psychodynamics and elements of change in the therapeutic process. So finally, Jungian psychotherapy has reached the point where it can be called an empirically proven, effective method.

  17. A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States.

    Science.gov (United States)

    Thomas, Zachariah; Bandali, Farooq; Sankaranarayanan, Jayashri; Reardon, Tom; Olsen, Keith M

    2015-12-01

    The purpose of this study is to determine the rate of prolonged empiric antibiotic therapy in adult ICUs in the United States. Our secondary objective is to examine the relationship between the prolonged empiric antibiotic therapy rate and certain ICU characteristics. Multicenter, prospective, observational, 72-hour snapshot study. Sixty-seven ICUs from 32 hospitals in the United States. Nine hundred ninety-eight patients admitted to the ICU between midnight on June 20, 2011, and June 21, 2011, were included in the study. None. Antibiotic orders were categorized as prophylactic, definitive, empiric, or prolonged empiric antibiotic therapy. Prolonged empiric antibiotic therapy was defined as empiric antibiotics that continued for at least 72 hours in the absence of adjudicated infection. Standard definitions from the Centers for Disease Control and Prevention were used to determine infection. Prolonged empiric antibiotic therapy rate was determined as the ratio of the total number of empiric antibiotics continued for at least 72 hours divided by the total number of empiric antibiotics. Univariate analysis of factors associated with the ICU prolonged empiric antibiotic therapy rate was conducted using Student t test. A total of 660 unique antibiotics were prescribed as empiric therapy to 364 patients. Of the empiric antibiotics, 333 of 660 (50%) were continued for at least 72 hours in instances where Centers for Disease Control and Prevention infection criteria were not met. Suspected pneumonia accounted for approximately 60% of empiric antibiotic use. The most frequently prescribed empiric antibiotics were vancomycin and piperacillin/tazobactam. ICUs that utilized invasive techniques for the diagnosis of ventilator-associated pneumonia had lower rates of prolonged empiric antibiotic therapy than those that did not, 45.1% versus 59.5% (p = 0.03). No other institutional factor was significantly associated with prolonged empiric antibiotic therapy rate. Half of all

  18. A grand canonical genetic algorithm for the prediction of multi-component phase diagrams and testing of empirical potentials

    International Nuclear Information System (INIS)

    Tipton, William W; Hennig, Richard G

    2013-01-01

    We present an evolutionary algorithm which predicts stable atomic structures and phase diagrams by searching the energy landscape of empirical and ab initio Hamiltonians. Composition and geometrical degrees of freedom may be varied simultaneously. We show that this method utilizes information from favorable local structure at one composition to predict that at others, achieving far greater efficiency of phase diagram prediction than a method which relies on sampling compositions individually. We detail this and a number of other efficiency-improving techniques implemented in the genetic algorithm for structure prediction code that is now publicly available. We test the efficiency of the software by searching the ternary Zr–Cu–Al system using an empirical embedded-atom model potential. In addition to testing the algorithm, we also evaluate the accuracy of the potential itself. We find that the potential stabilizes several correct ternary phases, while a few of the predicted ground states are unphysical. Our results suggest that genetic algorithm searches can be used to improve the methodology of empirical potential design. (paper)

  19. A grand canonical genetic algorithm for the prediction of multi-component phase diagrams and testing of empirical potentials.

    Science.gov (United States)

    Tipton, William W; Hennig, Richard G

    2013-12-11

    We present an evolutionary algorithm which predicts stable atomic structures and phase diagrams by searching the energy landscape of empirical and ab initio Hamiltonians. Composition and geometrical degrees of freedom may be varied simultaneously. We show that this method utilizes information from favorable local structure at one composition to predict that at others, achieving far greater efficiency of phase diagram prediction than a method which relies on sampling compositions individually. We detail this and a number of other efficiency-improving techniques implemented in the genetic algorithm for structure prediction code that is now publicly available. We test the efficiency of the software by searching the ternary Zr-Cu-Al system using an empirical embedded-atom model potential. In addition to testing the algorithm, we also evaluate the accuracy of the potential itself. We find that the potential stabilizes several correct ternary phases, while a few of the predicted ground states are unphysical. Our results suggest that genetic algorithm searches can be used to improve the methodology of empirical potential design.

  20. Science and the British Empire.

    Science.gov (United States)

    Harrison, Mark

    2005-03-01

    The last few decades have witnessed a flowering of interest in the history of science in the British Empire. This essay aims to provide an overview of some of the most important work in this area, identifying interpretative shifts and emerging themes. In so doing, it raises some questions about the analytical framework in which colonial science has traditionally been viewed, highlighting interactions with indigenous scientific traditions and the use of network-based models to understand scientific relations within and beyond colonial contexts.

  1. Utilizing a Two-stage Design to Investigate the Safety and Potential Efficacy of Monthly Naltrexone Plus Once-daily Bupropion as a Treatment for Methamphetamine Use Disorder.

    Science.gov (United States)

    Mooney, Larissa J; Hillhouse, Maureen P; Thomas, Christie; Ang, Alfonso; Sharma, Gaurav; Terry, Garth; Chang, Linda; Walker, Robrina; Trivedi, Madhukar; Croteau, David; Sparenborg, Steven; Ling, Walter

    2016-01-01

    This 2-stage open-label pilot study evaluated the safety and potential efficacy of naltrexone + bupropion as a pharmacotherapy for methamphetamine (MA) use disorder. The study was conducted in 2 stages of recruitment across 3 sites; 20 participants were enrolled in stage 1 and 29 participants were enrolled in stage 2. Eight weeks of open-label pharmacotherapy with a combination of extended-release injectable naltrexone (XR-NTX; Vivitrol) plus extended-release oral bupropion (BRP; Wellbutrin XL) were provided with a smartphone-assisted medication adherence platform. Participants met Diagnostic and Statistical Manual of Mental Disorders, 5th Edition criteria for severe MA use disorder, self-reported ≥20 days of MA use in the 30 days prior to consent, and submitted 3 MA-positive urine drug screens (UDS) out of 4 collected during screening. Participants attended clinic twice weekly for observed BRP dosing, UDS testing, assessments, and medical management; XR-NTX was administered at weeks 1 and 5. A BRP taper and follow-up visit occurred in week 9. Analyses evaluated effects of XR-NTX + BRP to determine the number of "responders" according to a statistically predefined response criterion (6 of 8 MA-negative UDS during the last 4 weeks of medication). The 2-stage design required that stage 1 yield ≥3 responders to continue to stage 2; 11 of the 49 participants met responder criteria across both stages (5 in stage 1, 6 in stage 2). Under the statistical analysis plan, study "success" required ≥9 responders. With 11 responders, the study demonstrated sufficient potential of naltrexone plus bupropion as a combination pharmacotherapy for MA use disorder to warrant further study.

  2. Design of the Multi-Sensor Monitoring in Congestive Heart Failure (MUSIC) study: prospective trial to assess the utility of continuous wireless physiologic monitoring in heart failure.

    Science.gov (United States)

    Anand, Inder S; Greenberg, Barry H; Fogoros, Richard N; Libbus, Imad; Katra, Rodolphe P

    2011-01-01

    Remote monitoring of heart failure (HF) patients may help in the early detection of acute HF decompensation before the onset of symptoms. Appropriate early intervention in these patients may reduce HF-related hospitalizations and costs. The MUSIC (Multi-Sensor Monitoring in Congestive Heart Failure) study comprises 2 multicenter nonrandomized phases (MUSIC-Development and MUSIC-Validation) designed to develop and validate an algorithm for the prediction of acute HF decompensation using multiple physiologic signals obtained from an external, adherent, multisensor system capable of intermittent transmission of physiologic signals. Data obtained from MUSIC-Development will be used to develop the algorithm to predict HF decompensation. The algorithm will be validated in MUSIC-Validation with the objectives of ≥ 60% sensitivity for correctly predicting an acute HF event, a false-positive patient status signal rate of ≤ 1.0 per patient-year, and a safety endpoint of ≤ 5% of patients experiencing significant adverse skin conditions related to the prolonged wearing of the adherent device. A total of 542 patients in New York Heart Association functional class III-IV HF, with ejection fraction ≤ 40% and a recent HF admission, are enrolled in MUSIC-Development (n = 180) and MUSIC-Validation (n = 362). All patients are remotely monitored for 90 days using the Corventis multisensor system that transmits bioimpedance, electrocardiogram, and accelerometer data. The MUSIC study has completed patient enrollment and follow-up in both phases. Once algorithm development is complete from the MUSIC-Development phase, the sequestered data set from the MUSIC-Validation phase will be used for algorithm validation. Published by Elsevier Inc.

  3. Monitoring peak power and cooling energy savings of shade trees and white surfaces in the Sacramento Municipal Utility District (SMUD) service area: Project design and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Akbari, H.; Bretz, S.; Hanford, J.; Rosenfeld, A.; Sailor, D.; Taha, H. [Lawrence Berkeley Lab., CA (United States); Bos, W. [Sacramento Municipal Utility District, CA (United States)

    1992-12-01

    Urban areas in warm climates create summer heat islands of daily average intensity of 3--5{degrees}C, adding to discomfort and increasing air-conditioning loads. Two important factors contributing to urban heat islands are reductions in albedo (lower overall city reflectance) and loss of vegetation (less evapotranspiration). Reducing summer heat islands by planting vegetation (shade trees) and increasing surface albedos, saves cooling energy, allows down-sizing of air conditioners, lowers air-conditioning peak demand, and reduces the emission of CO{sub 2} and other pollutants from electric power plants. The focus of this multi-year project, jointly sponsored by SMUD and the California Institute for Energy Efficiency (CIEE), was to measure the direct cooling effects of trees and white surfaces (mainly roofs) in a few buildings in Sacramento. The first-year project was to design the experiment and obtain base case data. We also obtained limited post retrofit data for some sites. This report provides an overview of the project activities during the first year at six sites. The measurement period for some of the sites was limited to September and October, which are transitional cooling months in Sacramento and hence the interpretation of results only apply to this period. In one house, recoating the dark roof with a high-albedo coating rendered air conditioning unnecessary for the month of September (possible savings of up to 10 kWh per day and 2 kW of non-coincidental peak power). Savings of 50% relative to an identical base case bungalow were achieved when a school bungalow`s roof and southeast wall were coated with a high-albedo coating during the same period. Our measured data for the vegetation sites do not indicate conclusive results because shade trees were small and the cooling period was almost over. We need to collect more data over a longer cooling season in order to demonstrate savings conclusively.

  4. Design Anthropology in Participatory Design

    DEFF Research Database (Denmark)

    Smith, Rachel Charlotte; Kjærsgaard, Mette Gislev

    2015-01-01

    This focus section explores the opportunities of design anthropology in participatory design as an approach to research and design in an increasingly global and digital world. Traditionally, ethnography has been used in Participatory design to research real-life contexts and challenges, and as ways...... to involve people in defining user-needs and design opportunities. As the boundaries between diverse – material, digital and networked – spaces and experiences become increasingly blurred, so do the conventional distinctions between research and design. The papers presented in this focus section explore...... opportunities of using design anthropology as a holistic and critical approach to addressing societal challenges and change, and a way for anthropologists and designers to engage in participatory research and design that extend beyond the empirical....

  5. The development of empirical models to evaluate energy use and energy cost in wastewater collection

    Science.gov (United States)

    Young, David Morgan

    This research introduces a unique data analysis method and develops empirical models to evaluate energy use and energy cost in wastewater collection systems using operational variables. From these models, several Best Management Processes (BMPs) are identified that should benefit utilities and positively impact the operation of existing infrastructure as well as the design of new infrastructure. Further, the conclusions generated herein display high transferability to certain manufacturing processes. Therefore, it is anticipated that these findings will also benefit pumping applications outside of the water sector. Wastewater treatment is often the single largest expense at the local government level. Not surprisingly, significant research effort has been expended on examining the energy used in wastewater treatment. However, the energy used in wastewater collection systems remains underexplored despite significant potential for energy savings. Estimates place potential energy savings as high as 60% within wastewater collection; which, if applied across the United States equates to the energy used by nearly 125,000 American homes. Employing three years of data from Renewable Water Resources (ReWa), the largest wastewater utility in the Upstate of South Carolina, this study aims to develop useful empirical equations that will allow utilities to efficiently evaluate the energy use and energy cost of its wastewater collection system. ReWa's participation was motivated, in part, by their recent adoption of the United States Environmental Protection Agency "Effective Utility Strategies" within which exists a focus on energy management. The study presented herein identifies two primary variables related to the energy use and cost associated with wastewater collection: Specific Energy (Es) and Specific Cost (Cs). These two variables were found to rely primarily on the volume pumped by the individual pump stations and exhibited similar power functions for the three year

  6. Empiric Antibiotic Prescribing Decisions Among Medical Residents: The Role of the Antibiogram.

    Science.gov (United States)

    Tallman, Gregory B; Vilches-Tran, Rowena A; Elman, Miriam R; Bearden, David T; Taylor, Jerusha E; Gorman, Paul N; McGregor, Jessina C

    2018-03-01

    OBJECTIVE To assess general medical residents' familiarity with antibiograms using a self-administered survey DESIGN Cross-sectional, single-center survey PARTICIPANTS Residents in internal medicine, family medicine, and pediatrics at an academic medical center METHODS Participants were administered an anonymous survey at our institution during regularly scheduled educational conferences between January and May 2012. Questions collected data regarding demographics, professional training; further open-ended questions assessed knowledge and use of antibiograms regarding possible pathogens, antibiotic regimens, and prescribing resources for 2 clinical vignettes; a series of directed, closed-ended questions followed. Bivariate analyses to compare responses between residency programs were performed. RESULTS Of 122 surveys distributed, 106 residents (87%) responded; internal medicine residents accounted for 69% of responses. More than 20% of residents could not accurately identify pathogens to target with empiric therapy or select therapy with an appropriate spectrum of activity in response to the clinical vignettes; correct identification of potential pathogens was not associated with selecting appropriate therapy. Only 12% of respondents identified antibiograms as a resource when prescribing empiric antibiotic therapy for scenarios in the vignettes, with most selecting the UpToDate online clinical decision support resource or The Sanford Guide. When directly questioned, 89% reported awareness of institutional antibiograms, but only 70% felt comfortable using them and only 44% knew how to access them. CONCLUSIONS When selecting empiric antibiotics, many residents are not comfortable using antibiograms as part of treatment decisions. Efforts to improve antibiotic use may benefit from residents being given additional education on both infectious diseases pharmacotherapy and antibiogram utilization. Infect Control Hosp Epidemiol 2018;1-6.

  7. Piecing Together the Roman Empire: A Story of Discovery and Triumph.

    Science.gov (United States)

    Richmond, Julie A.; And Others

    This story, written by middle school students and their teacher at Kingsbury School in Michigan, concerns the Ancient Roman Empire and is designed to be used to teach other middle school students. The story depicts a quest to reconstruct the Roman Empire from its beginnings as Ancient Italy, as a republic in the sixth century B.C., to the height…

  8. Appropriate methodologies for empirical bioethics: it's all relative.

    Science.gov (United States)

    Ives, Jonathan; Draper, Heather

    2009-05-01

    In this article we distinguish between philosophical bioethics (PB), descriptive policy orientated bioethics (DPOB) and normative policy oriented bioethics (NPOB). We argue that finding an appropriate methodology for combining empirical data and moral theory depends on what the aims of the research endeavour are, and that, for the most part, this combination is only required for NPOB. After briefly discussing the debate around the is/ought problem, and suggesting that both sides of this debate are misunderstanding one another (i.e. one side treats it as a conceptual problem, whilst the other treats it as an empirical claim), we outline and defend a methodological approach to NPOB based on work we have carried out on a project exploring the normative foundations of paternal rights and responsibilities. We suggest that given the prominent role already played by moral intuition in moral theory, one appropriate way to integrate empirical data and philosophical bioethics is to utilize empirically gathered lay intuition as the foundation for ethical reasoning in NPOB. The method we propose involves a modification of a long-established tradition on non-intervention in qualitative data gathering, combined with a form of reflective equilibrium where the demands of theory and data are given equal weight and a pragmatic compromise reached.

  9. Endogenizing technological change. Matching empirical evidence to modeling needs

    Energy Technology Data Exchange (ETDEWEB)

    Pizer, William A. [Resources for the Future, 1616 P Street NW, Washington, DC, 20009 (United States); Popp, David [Department of Public Administration, Center for Policy Research, The Maxwell School, Syracuse University, 426 Eggers Hall, Syracuse, NY 13244-1020 (United States); National Bureau of Economic Research (United States)

    2008-11-15

    Given that technologies to significantly reduce fossil fuel emissions are currently unavailable or only available at high cost, technological change will be a key component of any long-term strategy to reduce greenhouse gas emissions. In light of this, the amount of research on the pace, direction, and benefits of environmentally-friendly technological change has grown dramatically in recent years. This research includes empirical work estimating the magnitude of these effects, and modeling exercises designed to simulate the importance of endogenous technological change in response to climate policy. Unfortunately, few attempts have been made to connect these two streams of research. This paper attempts to bridge that gap. We review both the empirical and modeling literature on technological change. Our focus includes the research and development process, learning by doing, the role of public versus private research, and technology diffusion. Our goal is to provide an agenda for how both empirical and modeling research in these areas can move forward in a complementary fashion. In doing so, we discuss both how models used for policy evaluation can better capture empirical phenomena, and how empirical research can better address the needs of models used for policy evaluation. (author)

  10. Endogenizing technological change: Matching empirical evidence to modeling needs

    Energy Technology Data Exchange (ETDEWEB)

    Pizer, William A. [Resources for the Future, 1616 P Street NW, Washington, DC, 20009 (United States)], E-mail: pizer@rff.org; Popp, David [Department of Public Administration, Center for Policy Research, Maxwell School, Syracuse University, 426 Eggers Hall, Syracuse, NY 13244-1020 (United States); National Bureau of Economic Research (United States)], E-mail: dcpopp@maxwell.syr.edu

    2008-11-15

    Given that technologies to significantly reduce fossil fuel emissions are currently unavailable or only available at high cost, technological change will be a key component of any long-term strategy to reduce greenhouse gas emissions. In light of this, the amount of research on the pace, direction, and benefits of environmentally-friendly technological change has grown dramatically in recent years. This research includes empirical work estimating the magnitude of these effects, and modeling exercises designed to simulate the importance of endogenous technological change in response to climate policy. Unfortunately, few attempts have been made to connect these two streams of research. This paper attempts to bridge that gap. We review both the empirical and modeling literature on technological change. Our focus includes the research and development process, learning by doing, the role of public versus private research, and technology diffusion. Our goal is to provide an agenda for how both empirical and modeling research in these areas can move forward in a complementary fashion. In doing so, we discuss both how models used for policy evaluation can better capture empirical phenomena, and how empirical research can better address the needs of models used for policy evaluation.

  11. Empirical evidence for site coefficients in building code provisions

    Science.gov (United States)

    Borcherdt, R.D.

    2002-01-01

    Site-response coefficients, Fa and Fv, used in U.S. building code provisions are based on empirical data for motions up to 0.1 g. For larger motions they are based on theoretical and laboratory results. The Northridge earthquake of 17 January 1994 provided a significant new set of empirical data up to 0.5 g. These data together with recent site characterizations based on shear-wave velocity measurements provide empirical estimates of the site coefficients at base accelerations up to 0.5 g for Site Classes C and D. These empirical estimates of Fa and Fnu; as well as their decrease with increasing base acceleration level are consistent at the 95 percent confidence level with those in present building code provisions, with the exception of estimates for Fa at levels of 0.1 and 0.2 g, which are less than the lower confidence bound by amounts up to 13 percent. The site-coefficient estimates are consistent at the 95 percent confidence level with those of several other investigators for base accelerations greater than 0.3 g. These consistencies and present code procedures indicate that changes in the site coefficients are not warranted. Empirical results for base accelerations greater than 0.2 g confirm the need for both a short- and a mid- or long-period site coefficient to characterize site response for purposes of estimating site-specific design spectra.

  12. Succinct and fast empirical mode decomposition

    Science.gov (United States)

    Li, Hongguang; Hu, Yue; Li, Fucai; Meng, Guang

    2017-02-01

    Empirical mode decomposition (EMD) has been extensively studied and widely utilized in various areas. In this paper, order-statistics filters are used to replace the traditional interpolation methods and estimate envelopes of the EMD method. Window size selection criteria are proposed to optimize the processing results. Both simulated and experimental signal are applied to investigate characteristics and effectiveness of the proposed method. The results demonstrate that the envelope estimation procedure provides a tremendous enhancement of the EMD method. In the proposed method, application of the order-statistics filter can simplify the process of estimating envelopes and minimize the end effect of the traditional EMD method. Moreover, sifting stop criterion and window width selection are optimized to improve the decomposition speed and processed results. Hence, the processed method is fast, time efficient and effective, and is named as succinct and fast EMD (SF-EMD) in this paper. An application of multiple fault diagnosis for a rotor test rig verifies its potential in practical engineering.

  13. Empirical validation of directed functional connectivity.

    Science.gov (United States)

    Mill, Ravi D; Bagic, Anto; Bostan, Andreea; Schneider, Walter; Cole, Michael W

    2017-02-01

    Mapping directions of influence in the human brain connectome represents the next phase in understanding its functional architecture. However, a host of methodological uncertainties have impeded the application of directed connectivity methods, which have primarily been validated via "ground truth" connectivity patterns embedded in simulated functional MRI (fMRI) and magneto-/electro-encephalography (MEG/EEG) datasets. Such simulations rely on many generative assumptions, and we hence utilized a different strategy involving empirical data in which a ground truth directed connectivity pattern could be anticipated with confidence. Specifically, we exploited the established "sensory reactivation" effect in episodic memory, in which retrieval of sensory information reactivates regions involved in perceiving that sensory modality. Subjects performed a paired associate task in separate fMRI and MEG sessions, in which a ground truth reversal in directed connectivity between auditory and visual sensory regions was instantiated across task conditions. This directed connectivity reversal was successfully recovered across different algorithms, including Granger causality and Bayes network (IMAGES) approaches, and across fMRI ("raw" and deconvolved) and source-modeled MEG. These results extend simulation studies of directed connectivity, and offer practical guidelines for the use of such methods in clarifying causal mechanisms of neural processing. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. A novel bionic design of dental implant for promoting its long-term success using nerve growth factor (NGF): utilizing nano-springs to construct a stress-cushioning structure inside the implant.

    Science.gov (United States)

    He, Hao; Yao, Yang; Wang, Yanying; Wu, Yingying; Yang, Yang; Gong, Ping

    2012-08-01

    The absence of periodontium causes masticatory load in excess of the self-repairing potential of peri-implant bone; peri-implant bone loss caused by occlusal overload is not uncommon in patients and greatly diminishes chances of long-term success. Regenerative treatments may be useful in inducing peri-implant bone regeneration, but are only stopgap solutions to the aftermaths caused by the imperfect biomechanical compatibility of the dental implant. Despite promising success, the tissue-engineered periodontal ligament still needs a period of time to be perfected before being clinically applied. Hence, we propose a novel design of dental implant that utilizes nano-springs to construct a stress-cushioning structure inside the implant. Many studies have shown that NGF, a neurotrophin, is effective for nerve regeneration in both animal and clinical studies. Moreover, NGF has the potential to accelerate bone healing in patients with fracture and fracture nonunion and improve osseointegration of the implant. The key point of the design is to reduce stress concentrated around peri-implant bone by cushioning masticatory forces and distributing them to all the peri-implant bone through nano-springs, and promote osseoperception and osseointegration by NGF-induced nerve regeneration and new bone formation. This design, which transfers the main biomechanical interface of the implant from outside to inside, if proven to be valid, may to some extent compensate for the functions of lost periodontium in stress cushioning and proprioception.

  15. Integrated ensemble noise-reconstructed empirical mode decomposition for mechanical fault detection

    Science.gov (United States)

    Yuan, Jing; Ji, Feng; Gao, Yuan; Zhu, Jun; Wei, Chenjun; Zhou, Yu

    2018-05-01

    A new branch of fault detection is utilizing the noise such as enhancing, adding or estimating the noise so as to improve the signal-to-noise ratio (SNR) and extract the fault signatures. Hereinto, ensemble noise-reconstructed empirical mode decomposition (ENEMD) is a novel noise utilization method to ameliorate the mode mixing and denoised the intrinsic mode functions (IMFs). Despite the possibility of superior performance in detecting weak and multiple faults, the method still suffers from the major problems of the user-defined parameter and the powerless capability for a high SNR case. Hence, integrated ensemble noise-reconstructed empirical mode decomposition is proposed to overcome the drawbacks, improved by two noise estimation techniques for different SNRs as well as the noise estimation strategy. Independent from the artificial setup, the noise estimation by the minimax thresholding is improved for a low SNR case, which especially shows an outstanding interpretation for signature enhancement. For approximating the weak noise precisely, the noise estimation by the local reconfiguration using singular value decomposition (SVD) is proposed for a high SNR case, which is particularly powerful for reducing the mode mixing. Thereinto, the sliding window for projecting the phase space is optimally designed by the correlation minimization. Meanwhile, the reasonable singular order for the local reconfiguration to estimate the noise is determined by the inflection point of the increment trend of normalized singular entropy. Furthermore, the noise estimation strategy, i.e. the selection approaches of the two estimation techniques along with the critical case, is developed and discussed for different SNRs by means of the possible noise-only IMF family. The method is validated by the repeatable simulations to demonstrate the synthetical performance and especially confirm the capability of noise estimation. Finally, the method is applied to detect the local wear fault

  16. Dealing with the difficult utility

    International Nuclear Information System (INIS)

    Keats, D.E.; Sundquist, M.J.; Cross, J.P.

    1991-01-01

    STS HydroPower, Ltd. (STS) is an independent hydroelectric power developer involved in the full scope of hydroelectric activities. This includes the permitting, design, financing, turbine design and manufacturing, site construction and operation of small to mid-sized hydroelectric sites across the United States. At the present time, STS owns and operates nine sites in four states with a combined capacity of 20 megawatts. In dealing with the implementation of these sites, STS has dealt with five different utilities. In addition, in pursuing additional development opportunities throughout the United States, STS has had contact with numerous other utilities. During this time it would be fair to conclude that each of these utilities has exhibited its own personality with respect to dealing with independent developers. To the credit of the utility industry, the majority of these utilities have been helpful and supportive of independent projects, but a small number of utilities have approached projects from an initial and continuing adversarial position. The purpose of this paper is to examine those options and procedures available to the developer when a utility is encountered with a negative predisposition

  17. Metabolism and resistance of Fusarium spp. to the manzamine alkaloids via a putative retro pictet-spengler reaction and utility of the rational design of antimalarial and antifungal agents.

    Science.gov (United States)

    Kasanah, Noer; Farr, Lorelei Lucas; Gholipour, Abbas; Wedge, David E; Hamann, Mark T

    2014-08-01

    As a part of our continuing investigation of the manzamine alkaloids we studied the in vitro activity of the β-carboline containing manzamine alkaloids against Fusarium solani, Fusarium oxysporium, and Fusarium proliferatum by employing several bioassay techniques including one-dimensional direct bioautography, dilution, and plate susceptibility, and microtiter broth assays. In addition, we also studied the metabolism of the manzamine alkaloids by Fusarium spp. in order to facilitate the redesign of the compounds to prevent resistance of Fusarium spp. through metabolism. The present research reveals that the manzamine alkaloids are inactive against Fusarium spp. and the fungi transform manzamines via hydrolysis, reduction, and a retro Pictet-Spengler reaction. This is the first report to demonstrate an enzymatically retro Pictet-Spengler reaction. The results of this study reveal the utility of the rational design of metabolically stable antifungal agents from this class and the development of manzamine alkaloids as antimalarial drugs through the utilization of Fusarium's metabolic products to reconstruct the molecule.

  18. Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).

    Science.gov (United States)

    Moffett, Kristofer; Konteatis, Zenon; Nguyen, Duyan; Shetty, Rupa; Ludington, Jennifer; Fujimoto, Ted; Lee, Kyoung-Jin; Chai, Xiaomei; Namboodiri, Haridasan; Karpusas, Michael; Dorsey, Bruce; Guarnieri, Frank; Bukhtiyarova, Marina; Springman, Eric; Michelotti, Enrique

    2011-12-01

    Discovery of a new class of DFG-out p38α kinase inhibitors with no hinge interaction is described. A computationally assisted, virtual fragment-based drug design (vFBDD) platform was utilized to identify novel non-aromatic fragments which make productive hydrogen bond interactions with Arg 70 on the αC-helix. Molecules incorporating these fragments were found to be potent inhibitors of p38 kinase. X-ray co-crystal structures confirmed the predicted binding modes. A lead compound was identified as a potent (p38α IC(50)=22 nM) and highly selective (≥ 150-fold against 150 kinase panel) DFG-out p38 kinase inhibitor. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Asthma and aerobic exercise: a review of the empirical literature.

    Science.gov (United States)

    Avallone, Kimberly M; McLeish, Alison C

    2013-03-01

    The purpose of the present article was to provide a comprehensive review of the empirical literature on the association between asthma and aerobic exercise among adults. A literature search was conducted utilizing electronic search engines (i.e., PsycINFO and PubMed) using the following keyword algorithms: asthma AND (exercise OR physical activity). These searches resulted in approximately 5665 citations. Only results that were directly relevant were included in the present review. Overall, empirical evidence suggests that (1) individuals with asthma are less likely to engage in physical activity than those without asthma, (2) individuals with asthma are not biased in their subjective reporting of symptoms during aerobic exercise, (3) physical inactivity among individuals with asthma is associated with negative health consequences and increased asthma-related difficulties, and (4) regular aerobic exercise improves asthma symptom management, lung function, and mental health.

  20. Expert opinion vs. empirical evidence

    Science.gov (United States)

    Herman, Rod A; Raybould, Alan

    2014-01-01

    Expert opinion is often sought by government regulatory agencies when there is insufficient empirical evidence to judge the safety implications of a course of action. However, it can be reckless to continue following expert opinion when a preponderance of evidence is amassed that conflicts with this opinion. Factual evidence should always trump opinion in prioritizing the information that is used to guide regulatory policy. Evidence-based medicine has seen a dramatic upturn in recent years spurred by examples where evidence indicated that certain treatments recommended by expert opinions increased death rates. We suggest that scientific evidence should also take priority over expert opinion in the regulation of genetically modified crops (GM). Examples of regulatory data requirements that are not justified based on the mass of evidence are described, and it is suggested that expertise in risk assessment should guide evidence-based regulation of GM crops. PMID:24637724

  1. Role of the utility

    International Nuclear Information System (INIS)

    Bellin, A.

    1986-03-01

    It is common to say that a nuclear programme needs basic infrastructures such as an appropriate educational system, governmental organizations for regulation, decision and inspection, engineering organizations for design and implementation, industrial infrastructures for manufacturing, erection and commissioning, operation organizations for running and maintaining power plants. This schematic organization is not sufficient to succeed in a nuclear programme: one has to consider very carefully the attribution of responsibilities. It appears, that, among all the different systems which exist in the world for the organization of a nuclear project, it is always the utility which bears the overall responsibility for the implementation of the project. It defines objectives such as production capacity, schedule, price; it takes part in the definition of a national policy for energy supply, for the choice of a type of reactor, for the implementation of a national nuclear industry; it selects sites and conducts feasibility studies including a preliminary project; it participates in the definition of organization charts and selects contractors; it calls for and obtains authorizations from regulatory bodies; it manages the project, coordinates contractors and permanently ensures that goals are attained as regards safety, quality, schedule, costs. The French utility has directly taken charge of all these basic responsibilities and this is commonly considered as a major reason of the success of the French nuclear programme. Depending on its capacities, the utility may delegate some of these responsibilities - mainly concerning engineering and project management - to experienced firms. Nevertheless, one has to remember that the utility bears the final responsibility and that it is probably the organization most fully aware of the fact that the final goal is not the construction of a nuclear power station but the production of nuclear electricity in the best and safest conditions

  2. The effects of performance measurement and compensation on motivation : An empirical study

    NARCIS (Netherlands)

    Van Herpen, M; Van Praag, M; Cools, K

    This paper analyzes empirically the relationship between pay and performance. Economic and psychological theories predict that the design and implementation of a performance measurement and compensation system affect the motivation of employees. Our survey results demonstrate a positive relationship

  3. The effects of performance measurement and compensation on motivation : an empirical study

    NARCIS (Netherlands)

    van Herpen, M.; van Praag, M.; Cools, K.

    2005-01-01

    This paper analyzes empirically the relationship between pay and performance. Economic and psychological theories predict that the design and implementation of a performance measurement and compensation system affect the motivation of employees. Our survey results demonstrate a positive relationship

  4. Utilizing Faceted Structures for Information Systems Design.

    Science.gov (United States)

    Priss, Uta; Jacob, Elin

    1999-01-01

    Suggests that a faceted thesaurus should be used as the basis for organizing a small-scale institutional Web site. Contends that a faceted approach to knowledge organization can make the process of organization less random and more manageable. Reports on an informal survey of three Web sites, underscoring the problems of organization that can…

  5. Between Empire and Anti-Empire: African Mission in the 21st Century

    Directory of Open Access Journals (Sweden)

    Bate, Stuart C.

    2013-06-01

    Full Text Available There is always empire and anti-empire in societies. An analytical lens needs to see both together to provide a better understanding of human society. This is particularly important when it comes to issues of religion which resides in some form in both empire and anti-empire. This presentation will unpack five points. Firstly it will present a brief historiography of the existence of empire and anti-empire mainly but not exclusively as it relates to Christianity. Secondly it will provide the main parameters of a social analysis of the nature of empire and anti-empire. Thirdly it will articulate the specific role of religion (again mainly Christianity in the societies of empire and anti-empire. Fourthly it will apply these findings to the specific context of Africa (mainly South Africa indicating two signs of empire and anti-empire in our past and present context. Finally it will provide some goals for Mission in 21st century Africa which go beyond the empire/anti-empire paradigm. These are based on a vision of transformational authority centred in the paschal mystery.

  6. Environmental control implications of generating electric power from coal. 1977 technology status report. Appendix D. Assessment of NO/sub x/ control technology for coal fired utility boilers. [Low-excess-air, staged combustion, flu gas recirculation and burner design

    Energy Technology Data Exchange (ETDEWEB)

    1977-12-01

    An NOx control technology assessment study was conducted to examine the effectiveness of low-excess-air firing, staged combustion, flue gas recirculation, and current burner/boiler designs as applied to coal-fired utility boilers. Significant variations in NOx emissions exist with boiler type, firing method, and coal type, but a relative comparison of emissions control performance, cost, and operational considerations is presented for each method. The study emphasized the numerous operational factors that are of major importance to the user in selecting and implementing a combustion modification technique. Staged combustion and low-excess-air operation were identified as the most cost-effective methods for existing units. Close control of local air/fuel ratios and rigorous combustion equipment maintenance are essential to the success of both methods. Flue gas recirculation is relatively ineffective and has the added concern of tube erosion. More research is needed to resolve potential corrosion concerns with low-NOx operating modes. Low-NOx burners in conjunction with a compartmentalized windbox are capable of meeting a 0.6-lb/million Btu emission level on new units. Advanced burner designs are being developed to meet research emission goals of approximately 0.25 lb/MBtu.

  7. Teaching Empirical Software Engineering Using Expert Teams

    DEFF Research Database (Denmark)

    Kuhrmann, Marco

    2017-01-01

    Empirical software engineering aims at making software engineering claims measurable, i.e., to analyze and understand phenomena in software engineering and to evaluate software engineering approaches and solutions. Due to the involvement of humans and the multitude of fields for which software...... is crucial, software engineering is considered hard to teach. Yet, empirical software engineering increases this difficulty by adding the scientific method as extra dimension. In this paper, we present a Master-level course on empirical software engineering in which different empirical instruments...

  8. Determinants of Economic Growth: Empirical Evidence from Russian Regions

    Directory of Open Access Journals (Sweden)

    Svetlana Ledyaeva

    2008-06-01

    Full Text Available A modification of Barro and Sala-i-Martin empirical framework of growth model is specified to examine determinants of per capita growth in 74 Russian regions during period of 1996-2005. We utilize both panel and cross-sectional data. Results imply that in general regional growth in 1996-2005 is explained by the initial level of region's economic development, the 1998 financial crisis, domestic investments, and exports. Growth convergence between poor and rich regions in Russia was not found for the period studied.

  9. Identifying Typical Movements Among Indoor Objects - Concepts and Empirical Study

    DEFF Research Database (Denmark)

    Radaelli, Laura; Sabonis, Dovydas; Lu, Hua

    2013-01-01

    indoor moving objects. Specifically, the paper presents a method for the identification of movement patterns. Leveraging concepts from sequential pattern mining, the method takes into account the specifics of spatial movement and, in particular, the specifics of tracking data that captures indoor...... movement. For example, the paper’s proposal supports spatial aggregation and utilizes the topology of indoor spaces to achieve better performance. The paper reports on empirical studies with real and synthetic data that offer insights into the functional and computational aspects of its proposal....

  10. The Spallation Neutron Source (SNS) conceptual design shielding analysis

    International Nuclear Information System (INIS)

    Johnson, J.O.; Odano, N.; Lillie, R.A.

    1998-03-01

    The shielding design is important for the construction of an intense high-energy accelerator facility like the proposed Spallation Neutron Source (SNS) due to its impact on conventional facility design, maintenance operations, and since the cost for the radiation shielding shares a considerable part of the total facility costs. A calculational strategy utilizing coupled high energy Monte Carlo calculations and multi-dimensional discrete ordinates calculations, along with semi-empirical calculations, was implemented to perform the conceptual design shielding assessment of the proposed SNS. Biological shields have been designed and assessed for the proton beam transport system and associated beam dumps, the target station, and the target service cell and general remote maintenance cell. Shielding requirements have been assessed with respect to weight, space, and dose-rate constraints for operating, shutdown, and accident conditions. A discussion of the proposed facility design, conceptual design shielding requirements calculational strategy, source terms, preliminary results and conclusions, and recommendations for additional analyses are presented

  11. ANALYSES OF THE INFLUENCE OF MATERIAL CHARACTERISTICS ON PAVEMENT DESIGN

    Directory of Open Access Journals (Sweden)

    Nino Vukobratović

    2017-01-01

    Full Text Available Currently, only empirical design methods are used in the application of well-known standards for pavement structure design. Given this fact, it is assumed that material characteristics correspond to average quality materials. Thus, the aim of this study included examining the influence of material characteristics on pavement design analyzing changes in the cement bound base layer (CBL characteristics with respect to the occurrence of cracks and changes in the asphalt layer given typical seasonal changes. The study involved varying CBL modulus as 15 GPa, 10 GPa, and 5 GPa. Additionally, the moduli of asphalt layers were varied from 6 MPa to 2 MPa to simulate real conditions in pavement structure life. The analyses indicated that there was a significant difference in pavement behavior with respect to changes in material characteristics. Given these significant differences, it is extremely important to properly define material characteristics while using empirical design methods. Proper material characterization combined with the utilization of empirical and analytical methods increases the possibility of reducing layers thickness to design cost-effective structures.

  12. Trust in automation: integrating empirical evidence on factors that influence trust.

    Science.gov (United States)

    Hoff, Kevin Anthony; Bashir, Masooda

    2015-05-01

    We systematically review recent empirical research on factors that influence trust in automation to present a three-layered trust model that synthesizes existing knowledge. Much of the existing research on factors that guide human-automation interaction is centered around trust, a variable that often determines the willingness of human operators to rely on automation. Studies have utilized a variety of different automated systems in diverse experimental paradigms to identify factors that impact operators' trust. We performed a systematic review of empirical research on trust in automation from January 2002 to June 2013. Papers were deemed eligible only if they reported the results of a human-subjects experiment in which humans interacted with an automated system in order to achieve a goal. Additionally, a relationship between trust (or a trust-related behavior) and another variable had to be measured. All together, 101 total papers, containing 127 eligible studies, were included in the review. Our analysis revealed three layers of variability in human-automation trust (dispositional trust, situational trust, and learned trust), which we organize into a model. We propose design recommendations for creating trustworthy automation and identify environmental conditions that can affect the strength of the relationship between trust and reliance. Future research directions are also discussed for each layer of trust. Our three-layered trust model provides a new lens for conceptualizing the variability of trust in automation. Its structure can be applied to help guide future research and develop training interventions and design procedures that encourage appropriate trust. © 2014, Human Factors and Ergonomics Society.

  13. Empirical analysis of sexual recidivism

    Directory of Open Access Journals (Sweden)

    Lukić Natalija

    2015-01-01

    Full Text Available The paper empirically examines relation of some static factors to recidivism among sexual offenders. The research sample consists of data gathered from personal files of 82 convicted persons who are either currently in the prison in Sremska Mitrovica or who have already served their sentences. Some of the hypotheses of the research have been confirmed. Firstly, a link between age at initial offending against sexual freedom and sexual recidivism is found to be statistically significant. Moreover, sexual recidivism is associated with the type of first criminal offense against sexual freedom - there are greater chances for recidivism if the first crime is less serious (prohibited sexual acts. Lastly, sexual offenders generally commit the same type of crimes against sexual freedom and this link is statistically significant. It is possible to make a clear distinction between two groups of recidivists - those who choose to victimize children and juveniles and those whose victims are adults. On the other hand, early onset of criminal career is not found to be statistically important. The same is concluded for marital and socio-economic status as well as for the history of rule violation (except sex crimes.

  14. [An encyclopedia for the empire].

    Science.gov (United States)

    Stöltzner, Michael

    2008-03-01

    In the preface to the universal encyclopedia Die Kultur der Gegenwart (The Culture of the Present), the editor-in-chief Paul Hinneberg places his project--not openly but nevertheless unequivocally--in the tradition of the French Encyclopédie that Diderot and d'Alembert had organized from 1751 until 1765. The attempt to accomplish anew such a large-scale project and, in this way, to win the German Empire the kind of intellectual leadership which the Encyclopédie, in historical retrospect, had achieved for the epoch of Enlightenment, required to convince the leading scholars, scientists, and technicians of the nation to participate in the endeavor and to assemble their contributions under a common systematic agenda through which this universal encyclopedia would distinguish itself from all dictionaries and disciplinary encyclopedias. While the Encyclopédie followed to a large extent an empiricist philosophy, Hinneberg trusted in the integrative function of the concept of culture and the ability of his contributors to elucidate the history of their respective disciplines and to connect them with neighboring fields of culture. The present contributions argues that although, from a philosophical point of view, the historicist tack taken by Hinneberg makes the concept of culture quite blurry, it nevertheless provides enough cohesive structure such that the work, even though unfinished as a consequence of war and inflation, represents a faithful picture of its epoch that Hinneberg understands as an epoch of transition.

  15. Theoretical and Semi-Empirical Methods of Designing Ribbon Unwinders.

    Science.gov (United States)

    1982-06-01

    other hand, include the effects of parameters that exist during testing but are not included in the phisical analysis. Variations in test procedures and...0297 / 191 N UNLSFIEDmos EEmmoEEImiomEE EomhEmhhEmhhhhI EhohmhmhohEEEI,mEE~hEE~EEE IfLhI L. 2 28 AL . MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU...distrbution is Lnhm d 83 06 30 046 TABLE OF CONTENTS Page 1. INTRODUCTION & SUMMARY 1 2. EXPERIMENTAL. POGRAM 2.1 Test Plan 9 2.2 Ribbon Unwinder.Assembly 9

  16. Empirical evidence of study design biases in randomized trials

    DEFF Research Database (Denmark)

    Page, Matthew J.; Higgins, Julian P. T.; Clayton, Gemma

    2016-01-01

    search September 2012), and searched Ovid MEDLINE and Ovid EMBASE for studies indexed from Jan 2012-May 2015. Data were extracted by one author and verified by another. We combined estimates of average bias (e.g. ratio of odds ratios (ROR) or difference in standardised mean differences (dSMD)) in meta......-analyses using the random-effects model. Analyses were stratified by type of outcome ("mortality" versus "other objective" versus "subjective"). Direction of effect was standardised so that ROR ...) characteristic. Results: We included 24 studies. The available evidence suggests that intervention effect estimates may be exaggerated in trials with inadequate/unclear (versus adequate) sequence generation (ROR 0.93, 95% CI 0.86 to 0.99; 7 studies) and allocation concealment (ROR 0.90, 95% CI 0.84 to 0.97; 7...

  17. Mechanistic-empirical asphalt overlay thickness design and analysis system.

    Science.gov (United States)

    2009-10-01

    The placement of an asphalt overlay is the most common method used by the Texas Department of Transportation (TxDOT) to rehabilitate : existing asphalt and concrete pavements. The type of overlay and its required thickness are important decisions tha...

  18. Designing Adaptive Instructional Environments: Insights from Empirical Evidence

    Science.gov (United States)

    2011-10-01

    Session 3: 8 days after Session 2, pre- and post- “transfer” tests with exercises calling upon cell -referencing skills in the context of a structurally...are used to guide users through hyperspace by annotating links or making direct next-link suggestions, based on the goals, knowledge, and other...experimental results, and the shaded cells represent the adaptive techniques that distinguished the adaptive vs. nonadaptive conditions in each experiment

  19. Scenario Design for the Empirical Testing of Organizational Congruence

    National Research Council Canada - National Science Library

    Kleinman, David L; Levchuk, Georgiy M; Hutchins, Susan G; Kemple, William G

    2005-01-01

    ... (as measured using a multi-variant set of workload/congruence metrics) the better will that organization perform, and that mismatches are potential drivers for the adaptation of organization structure...

  20. The European Utility Requirement Document

    International Nuclear Information System (INIS)

    Roche, I.I.

    1999-01-01

    The major European electricity producers work on a common requirement document for future LWR plants since 1992. They aim at requirements acceptable together by the owners, the public and the authorities. Thus the designers can develop standard LWR designs acceptable everywhere in Europe and the utilities can open their consultations to vendors on common bases. Such a standardisation promotes an improvement of generation costs and of safety : public and authorities acceptance should be improved as well ; significant savings are expected in development and construction costs. Since the early stages of the project, the EUR group has grown significantly. It now includes utilities from nine European countries. Utilities from two other European countries are joining the group. Specific cooperation agreements are also in progress with a few extra-European partners